## Sat Nov 16 03:29:53 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin27/TLS_2_bin.12.fa -m mmseqs --itype genome -o TLS_2_bin.12 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/TLS_2_bin.12 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TLS2_k127_100682_31	1463909.KL585953_gene5647	1.689e-08	62.0	COG3631@1|root,COG3631@2|Bacteria,2GRE5@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
TLS2_k127_100682_33	1206729.BAFZ01000153_gene4420	2.285e-07	57.0	COG4030@1|root,COG4030@2|Bacteria,2GJFD@201174|Actinobacteria,4FVN7@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
TLS2_k127_100682_32	1037409.BJ6T_59890	1.896e-07	59.0	COG4030@1|root,COG4030@2|Bacteria,1NSDB@1224|Proteobacteria,2TSXU@28211|Alphaproteobacteria,3JXQR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
TLS2_k127_100682_34	500153.JOEK01000002_gene358	8.887e-07	57.0	COG1070@1|root,COG1070@2|Bacteria,2GNCR@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the FGGY kinase family	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS2_k127_100682_10	1246448.ANAZ01000002_gene3798	9.15e-84	286.0	2A651@1|root,30UXH@2|Bacteria,2IERM@201174|Actinobacteria	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS2_k127_100682_16	1246448.ANAZ01000002_gene3799	2.127e-68	240.0	COG1309@1|root,COG1309@2|Bacteria,2IMHK@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_100682_12	1463854.JOHT01000015_gene5285	2.613e-76	259.0	COG2133@1|root,COG2133@2|Bacteria,2I9ZW@201174|Actinobacteria	201174|Actinobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,GSDH
TLS2_k127_100682_17	1120950.KB892763_gene5570	5.464e-68	241.0	COG1414@1|root,COG1414@2|Bacteria,2GNHA@201174|Actinobacteria,4DUQN@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS2_k127_100682_22	469383.Cwoe_4785	1.827e-43	170.0	COG3386@1|root,COG3386@2|Bacteria,2HPQQ@201174|Actinobacteria,4CR3P@84995|Rubrobacteria	84995|Rubrobacteria	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	-	-	-	-	-	-	-	-	-	SGL
TLS2_k127_100682_6	1206731.BAGB01000041_gene8336	8.8e-133	437.0	COG0015@1|root,COG0015@2|Bacteria,2GM71@201174|Actinobacteria,4G5VP@85025|Nocardiaceae	201174|Actinobacteria	F	Adenylosuccinate lyase C-terminus	-	-	5.5.1.2	ko:K01857	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03307	RC00902	ko00000,ko00001,ko01000	-	-	-	ADSL_C,Lyase_1
TLS2_k127_100682_7	330084.JNYZ01000050_gene8594	6.842e-113	390.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,4E9Z0@85010|Pseudonocardiales	201174|Actinobacteria	C	1-deoxy-D-xylulose-5-phosphate synthase	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS2_k127_100682_5	591158.SSMG_04067	1.403e-136	448.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
TLS2_k127_100682_24	1123060.JONP01000026_gene3447	2.07e-38	158.0	COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2UNXP@28211|Alphaproteobacteria,2JQXX@204441|Rhodospirillales	204441|Rhodospirillales	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_100682_21	1464048.JNZS01000023_gene2567	1.087e-51	192.0	COG1028@1|root,COG1028@2|Bacteria,2I8W3@201174|Actinobacteria,4DD05@85008|Micromonosporales	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_100682_35	1214242.B446_25785	0.0006407	49.0	COG1917@1|root,COG1917@2|Bacteria,2IKXC@201174|Actinobacteria	201174|Actinobacteria	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_100682_23	1382304.JNIL01000001_gene1694	3.862e-43	179.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,4I2S5@91061|Bacilli,279RC@186823|Alicyclobacillaceae	91061|Bacilli	C	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_100682_19	285514.JNWO01000007_gene3387	5.885e-63	232.0	COG0395@1|root,COG0395@2|Bacteria,2GRTG@201174|Actinobacteria	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_100682_14	436229.JOEH01000015_gene5980	5.687e-73	259.0	COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria,2NKC1@228398|Streptacidiphilus	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_100682_25	926554.KI912671_gene487	1.058e-32	143.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_100682_18	1120950.KB892778_gene1048	8.081e-68	244.0	COG0673@1|root,COG0673@2|Bacteria,2IMUZ@201174|Actinobacteria	201174|Actinobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_100682_11	2045.KR76_00955	2.666e-83	288.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4DRTZ@85009|Propionibacteriales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.303,1.1.1.4	ko:K00004	ko00650,map00650	-	R02855,R02946,R10504	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N,Glu_dehyd_C
TLS2_k127_100682_8	1090318.ATTI01000001_gene948	1.038e-109	368.0	COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2UNXP@28211|Alphaproteobacteria,2KCTZ@204457|Sphingomonadales	204457|Sphingomonadales	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_100682_20	390989.JOEG01000006_gene734	7.47e-58	225.0	COG0491@1|root,COG0491@2|Bacteria,2GMPG@201174|Actinobacteria,4DIDN@85008|Micromonosporales	201174|Actinobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_100682_13	390989.JOEG01000006_gene733	5.161e-75	274.0	COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria,4DB2U@85008|Micromonosporales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100,1.1.1.304,1.1.1.76	ko:K00059,ko:K03366	ko00061,ko00333,ko00650,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00650,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R02855,R02946,R03707,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R09078,R10116,R10120,R10505,R11671	RC00029,RC00117,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_100682_26	1452535.JARD01000015_gene716	7.434e-28	125.0	COG0329@1|root,COG0329@2|Bacteria,2IBEF@201174|Actinobacteria,4FR4W@85023|Microbacteriaceae	201174|Actinobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_100682_3	1463821.JOGR01000011_gene2155	2.744e-207	652.0	COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria,4EYIK@85014|Glycomycetales	201174|Actinobacteria	C	PFAM FMN-dependent alpha-hydroxy acid dehydrogenase	lldD2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	1.1.2.3,1.1.3.15	ko:K00101,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00196,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	iNJ661.Rv1872c	FMN_dh
TLS2_k127_100682_2	767817.Desgi_3833	0.0	1220.0	COG2351@1|root,COG2351@2|Bacteria,1VM33@1239|Firmicutes,24X4S@186801|Clostridia	186801|Clostridia	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_100682_1	1273538.G159_19950	0.0	1309.0	COG2351@1|root,COG3409@1|root,COG2351@2|Bacteria,COG3409@2|Bacteria,1V08W@1239|Firmicutes	1239|Firmicutes	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	VRP1
TLS2_k127_100682_29	465541.ATCJ01000005_gene2024	5.531e-14	88.0	COG3409@1|root,COG3409@2|Bacteria,2I31Y@201174|Actinobacteria	201174|Actinobacteria	M	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
TLS2_k127_100682_0	208444.JNYY01000001_gene5181	0.0	1905.0	COG3209@1|root,COG3209@2|Bacteria,2GK1D@201174|Actinobacteria,4EABX@85010|Pseudonocardiales	201174|Actinobacteria	M	Insecticide toxin TcdB middle/N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
TLS2_k127_100682_9	1121946.AUAX01000002_gene67	1.813e-105	348.0	COG2203@1|root,COG2203@2|Bacteria,2GQ2V@201174|Actinobacteria,4DG4K@85008|Micromonosporales	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS2_k127_100682_15	1121946.AUAX01000002_gene66	1.79e-70	248.0	COG2203@1|root,COG2203@2|Bacteria,2IQAM@201174|Actinobacteria,4DCWS@85008|Micromonosporales	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS2_k127_100682_27	543632.JOJL01000002_gene8348	1.842e-21	100.0	COG1366@1|root,COG1366@2|Bacteria,2IJJS@201174|Actinobacteria,4DDFI@85008|Micromonosporales	2|Bacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	MEDS,STAS,STAS_2
TLS2_k127_100682_30	931627.MycrhDRAFT_4972	3.235e-11	68.0	COG5659@1|root,COG5659@2|Bacteria,2GIU9@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
TLS2_k127_100682_28	66874.JOFS01000088_gene6607	5.03e-19	89.0	COG4584@1|root,COG4584@2|Bacteria,2HKD7@201174|Actinobacteria	201174|Actinobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,rve
TLS2_k127_100682_4	1136417.AZWE01000051_gene3900	2.088e-146	478.0	COG3464@1|root,COG3464@2|Bacteria,2IQ9H@201174|Actinobacteria,4DBDU@85008|Micromonosporales	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
TLS2_k127_1046857_10	1121272.KB903291_gene3369	4.633e-143	460.0	COG0604@1|root,COG0604@2|Bacteria,2GMHR@201174|Actinobacteria,4D926@85008|Micromonosporales	201174|Actinobacteria	C	alcohol dehydrogenase	adh3	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
TLS2_k127_1046857_14	469383.Cwoe_0487	1.219e-127	418.0	COG1595@1|root,COG1595@2|Bacteria,2GKBH@201174|Actinobacteria,4CPXP@84995|Rubrobacteria	84995|Rubrobacteria	K	RNA polymerase, sigma-24 subunit, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_1046857_21	443218.AS9A_2340	1.021e-92	307.0	COG2128@1|root,COG2128@2|Bacteria,2I829@201174|Actinobacteria,23511@1762|Mycobacteriaceae	201174|Actinobacteria	L	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_1046857_37	561175.KB894094_gene2084	6.714e-23	99.0	2E460@1|root,32Z20@2|Bacteria,2GQGS@201174|Actinobacteria,4EKRA@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1046857_0	1089549.AZUQ01000001_gene1686	0.0	1667.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4EY58@85014|Glycomycetales	201174|Actinobacteria	C	2-oxoglutarate dehydrogenase C-terminal	kgd	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
TLS2_k127_1046857_29	1121272.KB903291_gene3411	5.192e-64	231.0	2DKVQ@1|root,30HQN@2|Bacteria,2IJHA@201174|Actinobacteria,4DDWT@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_4
TLS2_k127_1046857_12	356851.JOAN01000017_gene5904	3.795e-135	436.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4D9SZ@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1046857_27	35754.JNYJ01000056_gene9890	9.415e-75	259.0	COG0824@1|root,COG0824@2|Bacteria,2IMQK@201174|Actinobacteria,4DDPF@85008|Micromonosporales	201174|Actinobacteria	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1046857_16	263358.VAB18032_29931	1.044e-122	396.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4D9TH@85008|Micromonosporales	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_1046857_8	1136417.AZWE01000001_gene3757	1.218e-149	489.0	COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria,4D8P4@85008|Micromonosporales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_1046857_20	1464048.JNZS01000024_gene928	2.479e-93	323.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4D9A2@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase s1 and s6 chymotrypsin hap	pepD	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_1046857_3	35754.JNYJ01000007_gene2912	2e-240	750.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4D9V2@85008|Micromonosporales	201174|Actinobacteria	H	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS2_k127_1046857_1	1033730.CAHG01000007_gene2721	0.0	1470.0	COG1674@1|root,COG1674@2|Bacteria,2GJBR@201174|Actinobacteria,4DQ0N@85009|Propionibacteriales	201174|Actinobacteria	D	FtsK/SpoIIIE family	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE
TLS2_k127_1046857_24	1033730.CAHG01000007_gene2722	1.942e-83	293.0	28MNM@1|root,33XG4@2|Bacteria,2GVWV@201174|Actinobacteria	201174|Actinobacteria	S	WXG100 protein secretion system (Wss), protein YukD	-	-	-	-	-	-	-	-	-	-	-	-	YukD
TLS2_k127_1046857_32	1033730.CAHG01000007_gene2723	1.094e-38	164.0	COG0455@1|root,COG0455@2|Bacteria	2|Bacteria	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1046857_39	1237500.ANBA01000007_gene2954	3.047e-19	92.0	2CCAZ@1|root,2ZU2V@2|Bacteria,2H0KZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1046857_17	1122182.KB903820_gene81	4.973e-121	395.0	COG0500@1|root,COG2226@2|Bacteria,2IECW@201174|Actinobacteria,4DENZ@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_1046857_5	134676.ACPL_5886	1.148e-199	662.0	COG1388@1|root,COG1652@1|root,COG1388@2|Bacteria,COG1652@2|Bacteria,2I8YV@201174|Actinobacteria,4DAGE@85008|Micromonosporales	201174|Actinobacteria	M	PFAM Peptidoglycan-binding LysM	-	-	-	-	-	-	-	-	-	-	-	-	LysM
TLS2_k127_1046857_38	644283.Micau_0252	1.462e-19	95.0	2E4ST@1|root,32ZM5@2|Bacteria,2GSCH@201174|Actinobacteria,4DEKN@85008|Micromonosporales	201174|Actinobacteria	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
TLS2_k127_1046857_35	33876.JNXY01000031_gene2977	1.635e-25	111.0	COG4961@1|root,COG4961@2|Bacteria,2GUPQ@201174|Actinobacteria,4DEEV@85008|Micromonosporales	201174|Actinobacteria	U	TadE family	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS2_k127_1046857_36	219305.MCAG_03076	9.359e-25	110.0	COG4961@1|root,COG4961@2|Bacteria,2HUDF@201174|Actinobacteria,4DEGY@85008|Micromonosporales	201174|Actinobacteria	U	TadE family	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS2_k127_1046857_25	644283.Micau_0256	5.715e-81	280.0	COG4965@1|root,COG4965@2|Bacteria,2I2Z3@201174|Actinobacteria,4DB29@85008|Micromonosporales	201174|Actinobacteria	U	Type ii secretion system	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
TLS2_k127_1046857_23	644283.Micau_0257	4.327e-85	292.0	COG4965@1|root,COG4965@2|Bacteria,2GN6E@201174|Actinobacteria,4D9WI@85008|Micromonosporales	201174|Actinobacteria	U	Type ii secretion system	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
TLS2_k127_1046857_9	1464048.JNZS01000015_gene3711	9.451e-147	481.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4DBIQ@85008|Micromonosporales	201174|Actinobacteria	U	type II secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS2_k127_1046857_28	1136417.AZWE01000034_gene539	2.823e-72	254.0	COG0455@1|root,COG0455@2|Bacteria,2HT5K@201174|Actinobacteria,4D9T2@85008|Micromonosporales	201174|Actinobacteria	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1046857_40	1123320.KB889697_gene8936	8.138e-19	97.0	COG1261@1|root,COG1261@2|Bacteria,2HIQE@201174|Actinobacteria	201174|Actinobacteria	NO	SAF	-	-	-	-	-	-	-	-	-	-	-	-	SAF
TLS2_k127_1046857_33	1157632.AQWQ01000003_gene2093	1.447e-37	154.0	2DVVA@1|root,32V07@2|Bacteria,2IHH0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1046857_41	219305.MCAG_03084	2.026e-16	87.0	2ECZN@1|root,336WP@2|Bacteria,2IIYQ@201174|Actinobacteria,4DDDB@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1046857_13	543632.JOJL01000007_gene5588	3.908e-131	426.0	COG1752@1|root,COG1752@2|Bacteria,2GNBM@201174|Actinobacteria,4D9ZN@85008|Micromonosporales	201174|Actinobacteria	DTZ	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS2_k127_1046857_7	1464048.JNZS01000024_gene933	2.08e-155	514.0	COG0204@1|root,COG0204@2|Bacteria,2I8I4@201174|Actinobacteria,4D914@85008|Micromonosporales	201174|Actinobacteria	I	Glycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TLS2_k127_1046857_30	1120949.KB903339_gene7976	1.033e-61	216.0	COG2764@1|root,COG2764@2|Bacteria,2IKY5@201174|Actinobacteria,4DE8M@85008|Micromonosporales	201174|Actinobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
TLS2_k127_1046857_6	345341.KUTG_03952	2.949e-179	581.0	COG1944@1|root,COG1944@2|Bacteria,2GKBS@201174|Actinobacteria,4E1ZG@85010|Pseudonocardiales	201174|Actinobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
TLS2_k127_1046857_26	345341.KUTG_03953	1.836e-75	279.0	COG1944@1|root,COG1944@2|Bacteria,2IA4I@201174|Actinobacteria,4E7D2@85010|Pseudonocardiales	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	YcaO
TLS2_k127_1046857_18	469371.Tbis_0553	1.365e-111	388.0	COG0778@1|root,COG0778@2|Bacteria,2I97S@201174|Actinobacteria,4E3BJ@85010|Pseudonocardiales	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_1046857_22	345341.KUTG_03955	1.133e-87	301.0	COG0778@1|root,COG0778@2|Bacteria,2IIFZ@201174|Actinobacteria,4DZXC@85010|Pseudonocardiales	201174|Actinobacteria	C	Lantibiotic biosynthesis dehydratase C-term	-	-	-	-	-	-	-	-	-	-	-	-	Lant_dehydr_C
TLS2_k127_1046857_31	345341.KUTG_03956	2.989e-53	200.0	COG0778@1|root,COG0778@2|Bacteria,2H6TF@201174|Actinobacteria,4E7EU@85010|Pseudonocardiales	201174|Actinobacteria	C	Lantibiotic biosynthesis dehydratase C-term	-	-	-	-	-	-	-	-	-	-	-	-	Lant_dehydr_C
TLS2_k127_1046857_11	345341.KUTG_03957	7.769e-139	474.0	2DBDU@1|root,2Z8P5@2|Bacteria,2GKDN@201174|Actinobacteria,4E6QA@85010|Pseudonocardiales	201174|Actinobacteria	S	Lantibiotic dehydratase, C terminus	-	-	-	-	-	-	-	-	-	-	-	-	Lant_dehydr_N
TLS2_k127_1046857_42	469371.Tbis_0549	1.089e-07	61.0	2B5FQ@1|root,31YAC@2|Bacteria,2H0G0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1046857_2	1463853.JOHW01000004_gene2310	3.772e-258	830.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator, SARP family	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC5,BTAD,HTH_3,HTH_31,NB-ARC,TPR_10,TPR_12,TPR_7,TPR_8,Trans_reg_C
TLS2_k127_1046857_15	263358.VAB18032_29886	6.307e-126	445.0	COG3087@1|root,COG3087@2|Bacteria,2GNX9@201174|Actinobacteria,4D8E2@85008|Micromonosporales	201174|Actinobacteria	D	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1046857_34	263358.VAB18032_29876	6.623e-33	130.0	COG2154@1|root,COG2154@2|Bacteria,2IKXR@201174|Actinobacteria,4DFTN@85008|Micromonosporales	201174|Actinobacteria	H	Pterin 4 alpha carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
TLS2_k127_1046857_19	649831.L083_7176	6.404e-99	334.0	COG1716@1|root,COG1716@2|Bacteria,2I4MV@201174|Actinobacteria,4D8EZ@85008|Micromonosporales	201174|Actinobacteria	T	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1046857_4	263358.VAB18032_29866	5.422e-208	657.0	COG4992@1|root,COG4992@2|Bacteria,2GK0J@201174|Actinobacteria,4D9HT@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	rocD	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_1071868_12	1122611.KB903987_gene3971	0.0003276	44.0	COG0476@1|root,COG0476@2|Bacteria,2HGW4@201174|Actinobacteria,4EKF6@85012|Streptosporangiales	201174|Actinobacteria	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
TLS2_k127_1071868_0	926564.KI911765_gene4541	2.369e-195	620.0	COG3103@1|root,COG4991@2|Bacteria,2GJE2@201174|Actinobacteria	201174|Actinobacteria	T	Domain of unknown function (DUF1906)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1906
TLS2_k127_1071868_6	1306174.JODP01000016_gene7147	2.395e-72	261.0	COG5184@1|root,COG5184@2|Bacteria,2IG31@201174|Actinobacteria	201174|Actinobacteria	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,RCC1,RCC1_2
TLS2_k127_1071868_3	749927.AMED_7494	1.785e-84	286.0	COG1309@1|root,COG1309@2|Bacteria,2GV75@201174|Actinobacteria,4EBGH@85010|Pseudonocardiales	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
TLS2_k127_1071868_1	471853.Bcav_3697	1.019e-102	344.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
TLS2_k127_1071868_2	1121272.KB903289_gene4154	1.181e-91	314.0	2E9QH@1|root,333WV@2|Bacteria,2IC0C@201174|Actinobacteria,4DFVJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1071868_7	44060.JODL01000009_gene1906	5.716e-62	218.0	COG3153@1|root,COG3153@2|Bacteria,2IKX0@201174|Actinobacteria	201174|Actinobacteria	Q	acetyltransferase	-	-	-	ko:K03824,ko:K09964	-	-	-	-	ko00000,ko01000	-	-	-	ACT_3,ACT_7,Acetyltransf_1,Acetyltransf_7,Acetyltransf_9
TLS2_k127_1071868_9	1133849.O3I_025515	4.474e-13	75.0	COG4710@1|root,COG4710@2|Bacteria,2GXXT@201174|Actinobacteria,4G33R@85025|Nocardiaceae	201174|Actinobacteria	S	CopG domain protein DNA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1071868_8	35754.JNYJ01000034_gene2119	4.766e-20	93.0	2B2W2@1|root,31VGK@2|Bacteria,2HBBH@201174|Actinobacteria,4DKET@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_1071868_11	1415166.NONO_c30050	0.0001808	48.0	COG2334@1|root,COG2334@2|Bacteria,2I6RZ@201174|Actinobacteria,4G00A@85025|Nocardiaceae	201174|Actinobacteria	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase
TLS2_k127_1071868_5	1169161.KB897734_gene356	7.113e-77	261.0	COG2258@1|root,COG2258@2|Bacteria,2GMBE@201174|Actinobacteria	201174|Actinobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
TLS2_k127_1071868_4	35754.JNYJ01000015_gene8580	1.922e-80	270.0	COG0328@1|root,COG0328@2|Bacteria,2GK53@201174|Actinobacteria,4DDG3@85008|Micromonosporales	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
TLS2_k127_1147595_14	391037.Sare_1636	1.17e-164	533.0	COG0443@1|root,COG3266@1|root,COG0443@2|Bacteria,COG3266@2|Bacteria,2GNTE@201174|Actinobacteria,4DM1N@85008|Micromonosporales	201174|Actinobacteria	O	Hsp70 protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
TLS2_k127_1147595_7	1869.MB27_42735	2.477e-210	663.0	COG0699@1|root,COG0699@2|Bacteria,2GK6T@201174|Actinobacteria,4D9EK@85008|Micromonosporales	201174|Actinobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N,MMR_HSR1
TLS2_k127_1147595_5	1869.MB27_42740	5.038e-221	700.0	COG0699@1|root,COG0699@2|Bacteria,2GNGP@201174|Actinobacteria,4DB0Z@85008|Micromonosporales	201174|Actinobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
TLS2_k127_1147595_44	391037.Sare_1634	1.704e-15	87.0	2DBVZ@1|root,2ZBDU@2|Bacteria,2H9JZ@201174|Actinobacteria,4DK6F@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1147595_10	1869.MB27_42750	5.444e-185	610.0	COG2197@1|root,COG2197@2|Bacteria,2GNUY@201174|Actinobacteria,4D8EH@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_1147595_26	1150864.MILUP08_42496	2.321e-95	319.0	COG0169@1|root,COG0169@2|Bacteria,2GPQQ@201174|Actinobacteria,4D8NH@85008|Micromonosporales	201174|Actinobacteria	E	Shikimate	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2552c	Shikimate_DH,Shikimate_dh_N
TLS2_k127_1147595_20	1136417.AZWE01000003_gene3373	1.264e-123	407.0	COG1559@1|root,COG1559@2|Bacteria,2GKGQ@201174|Actinobacteria,4DACH@85008|Micromonosporales	201174|Actinobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
TLS2_k127_1147595_37	219305.MCAG_04863	5.391e-53	194.0	COG0816@1|root,COG0816@2|Bacteria,2IQB0@201174|Actinobacteria,4DD5I@85008|Micromonosporales	201174|Actinobacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	ruvX	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
TLS2_k127_1147595_0	390989.JOEG01000012_gene3271	0.0	1349.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4DA2Y@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS2_k127_1147595_42	35754.JNYJ01000001_gene7424	2.545e-26	113.0	2EGGE@1|root,33A8E@2|Bacteria,2I1AH@201174|Actinobacteria,4DFPB@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1147595_40	1136417.AZWE01000003_gene3377	2.221e-45	169.0	COG4768@1|root,COG4768@2|Bacteria,2II1J@201174|Actinobacteria,4DCPY@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF948)	-	-	-	-	-	-	-	-	-	-	-	-	DUF948
TLS2_k127_1147595_38	356851.JOAN01000007_gene4123	3.351e-52	210.0	2DPQY@1|root,33311@2|Bacteria,2ICVJ@201174|Actinobacteria,4DC60@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1147595_8	134676.ACPL_6495	1.438e-208	657.0	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4D9FJ@85008|Micromonosporales	201174|Actinobacteria	L	ATPase related to the helicase subunit of the Holliday junction resolvase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
TLS2_k127_1147595_39	1150864.MILUP08_42482	8.244e-51	191.0	COG0454@1|root,COG0456@2|Bacteria,2I3I7@201174|Actinobacteria,4DF5C@85008|Micromonosporales	201174|Actinobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,FR47
TLS2_k127_1147595_47	1121272.KB903272_gene248	2.452e-06	51.0	2DCY1@1|root,2ZFS6@2|Bacteria,2GWZI@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1147595_3	1464048.JNZS01000019_gene2268	6.443e-319	985.0	COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,4DB1U@85008|Micromonosporales	201174|Actinobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TLS2_k127_1147595_17	1121946.AUAX01000007_gene2972	2.432e-146	476.0	COG1396@1|root,COG1396@2|Bacteria,2GNQ9@201174|Actinobacteria,4DG9X@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,TPR_16
TLS2_k127_1147595_36	1089545.KB913037_gene9006	1.744e-58	217.0	COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,2H1NS@201174|Actinobacteria,4EDPY@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,HTH_31,NB-ARC,TPR_10,TPR_12,TPR_7,Trans_reg_C
TLS2_k127_1147595_28	644283.Micau_2800	1.455e-80	288.0	COG0515@1|root,COG0515@2|Bacteria,2IE68@201174|Actinobacteria,4DA3N@85008|Micromonosporales	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_1147595_9	644283.Micau_2299	3.072e-205	654.0	COG0124@1|root,COG0124@2|Bacteria,2GIYJ@201174|Actinobacteria,4DAIU@85008|Micromonosporales	201174|Actinobacteria	J	Histidine--tRNA ligase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TLS2_k127_1147595_22	263358.VAB18032_14755	5.732e-119	404.0	COG0491@1|root,COG0491@2|Bacteria,2GJU0@201174|Actinobacteria,4D99C@85008|Micromonosporales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_1147595_35	649831.L083_6057	1.995e-63	227.0	COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria,4D8PD@85008|Micromonosporales	201174|Actinobacteria	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
TLS2_k127_1147595_34	1246995.AFR_31030	1.036e-66	237.0	COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria,4D8FQ@85008|Micromonosporales	201174|Actinobacteria	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
TLS2_k127_1147595_1	543632.JOJL01000026_gene2528	0.0	1327.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4DB9Q@85008|Micromonosporales	201174|Actinobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TLS2_k127_1147595_32	644283.Micau_2294	3.633e-69	241.0	COG0503@1|root,COG0503@2|Bacteria,2IM7C@201174|Actinobacteria,4D8J6@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
TLS2_k127_1147595_24	219305.MCAG_04840	1.151e-111	374.0	COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria,4DAXJ@85008|Micromonosporales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_1147595_11	1464048.JNZS01000026_gene840	3.021e-179	583.0	COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4D8XP@85008|Micromonosporales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_1147595_43	644283.Micau_2291	4.961e-20	96.0	COG1862@1|root,COG1862@2|Bacteria,2IQSP@201174|Actinobacteria,4DFMC@85008|Micromonosporales	201174|Actinobacteria	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TLS2_k127_1147595_13	263358.VAB18032_14715	7.692e-169	544.0	COG2255@1|root,COG2255@2|Bacteria,2GJZF@201174|Actinobacteria,4D9CV@85008|Micromonosporales	201174|Actinobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
TLS2_k127_1147595_27	219305.MCAG_04836	2.725e-83	281.0	COG0632@1|root,COG0632@2|Bacteria,2GN17@201174|Actinobacteria,4D9VM@85008|Micromonosporales	201174|Actinobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009378,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
TLS2_k127_1147595_29	263358.VAB18032_14705	2.308e-77	263.0	COG0817@1|root,COG0817@2|Bacteria,2GJI5@201174|Actinobacteria,4DCPZ@85008|Micromonosporales	201174|Actinobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
TLS2_k127_1147595_23	561175.KB894093_gene3088	9.7e-114	380.0	COG1404@1|root,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria,4EI5B@85012|Streptosporangiales	201174|Actinobacteria	O	Peptidase inhibitor I9	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,P_proprotein,Peptidase_S8
TLS2_k127_1147595_21	561175.KB894093_gene3088	1.617e-121	402.0	COG1404@1|root,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria,4EI5B@85012|Streptosporangiales	201174|Actinobacteria	O	Peptidase inhibitor I9	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,P_proprotein,Peptidase_S8
TLS2_k127_1147595_31	263358.VAB18032_14685	2.894e-71	246.0	COG1309@1|root,COG1309@2|Bacteria,2I9NV@201174|Actinobacteria,4DCPE@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
TLS2_k127_1147595_6	356851.JOAN01000007_gene4095	1.382e-211	669.0	COG0477@1|root,COG2814@2|Bacteria,2H4H5@201174|Actinobacteria,4D9KH@85008|Micromonosporales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	ko:K05557	-	-	-	-	ko00000,ko02000	2.A.1.3.7	-	-	MFS_1
TLS2_k127_1147595_25	471852.Tcur_2245	5.42e-106	355.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4EIS8@85012|Streptosporangiales	201174|Actinobacteria	K	Sir2 family	cobB2	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
TLS2_k127_1147595_45	649831.L083_1053	1.743e-15	79.0	2DQ7G@1|root,3353J@2|Bacteria,2ISPG@201174|Actinobacteria,4DF4K@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
TLS2_k127_1147595_16	644283.Micau_2889	7.371e-155	494.0	COG1801@1|root,COG1801@2|Bacteria,2HU1R@201174|Actinobacteria,4DADR@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS2_k127_1147595_4	103733.JNYO01000030_gene1474	2.465e-229	724.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4DZA4@85010|Pseudonocardiales	201174|Actinobacteria	L	Belongs to the DEAD box helicase family	deaD	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
TLS2_k127_1147595_18	644283.Micau_2261	2.468e-137	441.0	COG0217@1|root,COG0217@2|Bacteria,2GJ4G@201174|Actinobacteria,4D8KZ@85008|Micromonosporales	201174|Actinobacteria	K	transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TLS2_k127_1147595_30	1394178.AWOO02000029_gene4576	4.294e-77	266.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4EH1T@85012|Streptosporangiales	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
TLS2_k127_1147595_15	43354.JOIJ01000002_gene4584	1.221e-163	522.0	COG0214@1|root,COG0214@2|Bacteria,2GK1T@201174|Actinobacteria,4DXUJ@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
TLS2_k127_1147595_41	219305.MCAG_04818	1.27e-43	166.0	COG1704@1|root,COG1704@2|Bacteria,2I3ZI@201174|Actinobacteria,4DD8Z@85008|Micromonosporales	201174|Actinobacteria	S	LemA family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1147595_12	644283.Micau_2257	1.556e-177	565.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,4D9M9@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
TLS2_k127_1147595_19	263358.VAB18032_14525	6.195e-124	415.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,4DA37@85008|Micromonosporales	201174|Actinobacteria	M	Bacterial lipid A biosynthesis acyltransferase	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
TLS2_k127_1147595_33	391037.Sare_1773	1.729e-67	243.0	COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4DCRP@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.11,2.7.8.5	ko:K00995,ko:K00999	ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070	-	R01801,R01802	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_1147595_2	644283.Micau_2254	0.0	1120.0	COG0480@1|root,COG0480@2|Bacteria,2GKRU@201174|Actinobacteria,4D9YS@85008|Micromonosporales	201174|Actinobacteria	J	elongation factor G	fusA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_1186321_33	219305.MCAG_03776	1.232e-105	347.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria,4D8GQ@85008|Micromonosporales	201174|Actinobacteria	S	LPPG FO 2-phospho-L-lactate transferase	cofD	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0043743,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
TLS2_k127_1186321_27	219305.MCAG_03775	1.2e-114	380.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4DC1F@85008|Micromonosporales	201174|Actinobacteria	C	F420-0:Gamma-glutamyl ligase	fbiB	GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase,Nitroreductase
TLS2_k127_1186321_22	33876.JNXY01000006_gene1129	2.28e-145	473.0	COG0836@1|root,COG0836@2|Bacteria,2GIRM@201174|Actinobacteria,4D91K@85008|Micromonosporales	201174|Actinobacteria	M	Mannose-1-phosphate guanylyltransferase	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
TLS2_k127_1186321_8	263358.VAB18032_09440	1.197e-214	673.0	COG0438@1|root,COG0438@2|Bacteria,2GK9J@201174|Actinobacteria,4D8HN@85008|Micromonosporales	201174|Actinobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_1186321_40	219305.MCAG_03769	1.318e-73	256.0	COG0318@1|root,COG0318@2|Bacteria,2GIX4@201174|Actinobacteria,4DBMU@85008|Micromonosporales	201174|Actinobacteria	IQ	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
TLS2_k127_1186321_18	369723.Strop_2135	1.74e-171	563.0	COG3119@1|root,COG3119@2|Bacteria,2IDUS@201174|Actinobacteria,4DCI6@85008|Micromonosporales	201174|Actinobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_1186321_16	1150864.MILUP08_43218	1.845e-181	582.0	COG2242@1|root,COG2242@2|Bacteria,2IAR0@201174|Actinobacteria,4D9FM@85008|Micromonosporales	201174|Actinobacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1186321_58	1136417.AZWE01000008_gene2243	6.291e-10	61.0	2AGY4@1|root,3176Q@2|Bacteria,2HBIZ@201174|Actinobacteria,4DKB1@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1186321_0	219305.MCAG_03768	5e-324	1009.0	COG0365@1|root,COG0365@2|Bacteria,2GM20@201174|Actinobacteria,4D8NB@85008|Micromonosporales	201174|Actinobacteria	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_1186321_48	356851.JOAN01000001_gene3887	7.652e-39	156.0	2DCYM@1|root,2ZFUI@2|Bacteria,2IG1E@201174|Actinobacteria,4DCZS@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1186321_6	263358.VAB18032_09410	6.092e-239	746.0	COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria,4D8DD@85008|Micromonosporales	201174|Actinobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS2_k127_1186321_2	356851.JOAN01000001_gene3878	9.729e-290	942.0	COG3087@1|root,COG3087@2|Bacteria,2GNX9@201174|Actinobacteria,4DAG9@85008|Micromonosporales	201174|Actinobacteria	D	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1186321_42	103733.JNYO01000006_gene1698	1.781e-65	237.0	COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria,4E2MB@85010|Pseudonocardiales	201174|Actinobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	GO:0008150,GO:0040007	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3275c	AIRC
TLS2_k127_1186321_19	644283.Micau_0937	5.157e-170	542.0	COG0026@1|root,COG0026@2|Bacteria,2GJCU@201174|Actinobacteria,4D90F@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
TLS2_k127_1186321_17	263358.VAB18032_09415	7.36e-181	599.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4DAJR@85008|Micromonosporales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_1186321_29	35754.JNYJ01000008_gene3232	3.328e-110	373.0	COG1020@1|root,COG1020@2|Bacteria,2GSRJ@201174|Actinobacteria,4DI0J@85008|Micromonosporales	201174|Actinobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	Condensation
TLS2_k127_1186321_1	263358.VAB18032_09380	2.979e-299	931.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4D970@85008|Micromonosporales	201174|Actinobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
TLS2_k127_1186321_30	1304865.JAGF01000001_gene1580	9.097e-110	364.0	COG0500@1|root,COG2226@2|Bacteria,2GNTH@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_1186321_53	1455608.JDTH01000010_gene78	1.676e-21	97.0	COG0262@1|root,arCOG01490@2157|Archaea	2157|Archaea	H	Belongs to the dihydrofolate reductase family	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_1186321_43	644283.Micau_1695	4.907e-59	215.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4DDIK@85008|Micromonosporales	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_1186321_51	479431.Namu_1806	5.403e-28	127.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4EW1U@85013|Frankiales	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_1186321_14	219305.MCAG_03757	2.073e-195	641.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4D9XC@85008|Micromonosporales	201174|Actinobacteria	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
TLS2_k127_1186321_56	391037.Sare_0869	2.405e-16	82.0	2EPYK@1|root,33HJ6@2|Bacteria,2IR9K@201174|Actinobacteria,4DF2Y@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1186321_21	219305.MCAG_03755	5.305e-152	497.0	COG2120@1|root,COG2120@2|Bacteria,2H2NY@201174|Actinobacteria,4DBG1@85008|Micromonosporales	201174|Actinobacteria	S	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics	mca	-	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_1186321_50	1464048.JNZS01000040_gene4041	5.186e-29	121.0	2DRBP@1|root,33B4I@2|Bacteria,2IMPF@201174|Actinobacteria,4DERK@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4307)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4307
TLS2_k127_1186321_39	1464048.JNZS01000040_gene4040	2.342e-74	252.0	COG0782@1|root,COG0782@2|Bacteria,2GNZV@201174|Actinobacteria,4DCPJ@85008|Micromonosporales	201174|Actinobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0071944	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TLS2_k127_1186321_15	1150864.MILUP08_41016	1.032e-191	607.0	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria,4DB0R@85008|Micromonosporales	201174|Actinobacteria	E	Threonine dehydratase	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
TLS2_k127_1186321_12	263358.VAB18032_09345	1.69e-197	625.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4DB5V@85008|Micromonosporales	201174|Actinobacteria	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS2_k127_1186321_13	35754.JNYJ01000004_gene5820	9.648e-196	616.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4DAII@85008|Micromonosporales	201174|Actinobacteria	E	Cys met metabolism pyridoxal-phosphate-dependent	metB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1079	Cys_Met_Meta_PP
TLS2_k127_1186321_44	263358.VAB18032_09330	4.308e-58	205.0	COG0537@1|root,COG0537@2|Bacteria,2IHPT@201174|Actinobacteria,4DEC7@85008|Micromonosporales	201174|Actinobacteria	FG	Histidine triad (HIT) protein	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
TLS2_k127_1186321_35	263358.VAB18032_11045	8.042e-93	312.0	arCOG06227@1|root,2ZCRG@2|Bacteria,2I96P@201174|Actinobacteria,4D8X0@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
TLS2_k127_1186321_45	1464048.JNZS01000008_gene6068	9.327e-56	205.0	COG3764@1|root,COG3764@2|Bacteria,2IR30@201174|Actinobacteria,4DCMF@85008|Micromonosporales	201174|Actinobacteria	M	peptidase C60 sortase A and B	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
TLS2_k127_1186321_10	882083.SacmaDRAFT_5221	3.227e-212	681.0	COG2409@1|root,COG2409@2|Bacteria,2GIRQ@201174|Actinobacteria,4DZH4@85010|Pseudonocardiales	201174|Actinobacteria	S	RND superfamily	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_1186321_28	263358.VAB18032_09325	1.156e-110	361.0	COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,4DAA5@85008|Micromonosporales	201174|Actinobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS2_k127_1186321_41	1121926.AXWO01000003_gene784	4.346e-72	253.0	2A64V@1|root,30UXB@2|Bacteria,2H965@201174|Actinobacteria,4F02C@85014|Glycomycetales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1186321_31	35754.JNYJ01000008_gene3232	1.93e-106	361.0	COG1020@1|root,COG1020@2|Bacteria,2GSRJ@201174|Actinobacteria,4DI0J@85008|Micromonosporales	201174|Actinobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	Condensation
TLS2_k127_1186321_4	1120950.KB892709_gene4149	2.869e-267	833.0	COG1132@1|root,COG1132@2|Bacteria,2GMZI@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_1186321_3	1120950.KB892709_gene4148	2.456e-276	866.0	COG1132@1|root,COG1132@2|Bacteria,2GMZI@201174|Actinobacteria,4DPSI@85009|Propionibacteriales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
TLS2_k127_1186321_49	543632.JOJL01000008_gene5915	1.254e-29	120.0	2B2JD@1|root,31V4M@2|Bacteria,2GUZD@201174|Actinobacteria,4DFNU@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1186321_24	1246995.AFR_05475	3.612e-140	451.0	COG0265@1|root,COG0265@2|Bacteria,2GNZT@201174|Actinobacteria,4DCKP@85008|Micromonosporales	201174|Actinobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_1186321_5	35754.JNYJ01000004_gene5831	4.01e-243	774.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,2GIXE@201174|Actinobacteria,4DAXK@85008|Micromonosporales	201174|Actinobacteria	EK	Cystathionine beta-synthase	cbs	GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
TLS2_k127_1186321_25	219305.MCAG_03739	1.147e-120	396.0	COG2755@1|root,COG2755@2|Bacteria,2GMVS@201174|Actinobacteria,4D9ZZ@85008|Micromonosporales	201174|Actinobacteria	E	G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS2_k127_1186321_34	1246995.AFR_05415	5.229e-97	323.0	COG2755@1|root,COG2755@2|Bacteria,2I9EE@201174|Actinobacteria,4D9ZC@85008|Micromonosporales	201174|Actinobacteria	E	G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS2_k127_1186321_7	35754.JNYJ01000004_gene5835	1.547e-228	711.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4DAE8@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_1186321_38	1136417.AZWE01000007_gene1933	1.869e-74	260.0	COG4760@1|root,COG4760@2|Bacteria,2GNCK@201174|Actinobacteria,4DASZ@85008|Micromonosporales	201174|Actinobacteria	S	Bax inhibitor 1 like	-	-	-	-	-	-	-	-	-	-	-	-	BaxI_1
TLS2_k127_1186321_32	1179773.BN6_35220	8.39e-106	360.0	COG2890@1|root,COG2890@2|Bacteria,2GITA@201174|Actinobacteria	201174|Actinobacteria	J	S-adenosyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_19
TLS2_k127_1186321_11	1150864.MILUP08_40999	6.321e-201	642.0	COG1287@1|root,COG1287@2|Bacteria,2HBRT@201174|Actinobacteria,4D9I9@85008|Micromonosporales	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1186321_9	1136417.AZWE01000007_gene1932	7.428e-213	669.0	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,4D8WG@85008|Micromonosporales	201174|Actinobacteria	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_1186321_55	219305.MCAG_03732	2.972e-17	92.0	2EH1F@1|root,33ATF@2|Bacteria,2IJ1A@201174|Actinobacteria,4DDP1@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1186321_23	219305.MCAG_03731	2.594e-142	465.0	COG1721@1|root,COG1721@2|Bacteria,2I9E2@201174|Actinobacteria,4DA7C@85008|Micromonosporales	201174|Actinobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_1186321_20	1150864.MILUP08_40995	2.14e-163	520.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4DAWH@85008|Micromonosporales	201174|Actinobacteria	S	ATPase associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_1186321_57	263358.VAB18032_09240	4.507e-15	82.0	2EG5A@1|root,339X8@2|Bacteria,2INII@201174|Actinobacteria,4DEBN@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1186321_52	1246995.AFR_05370	4.588e-23	111.0	2DPEM@1|root,331S3@2|Bacteria,2GSRU@201174|Actinobacteria,4DBK0@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
TLS2_k127_1186321_26	263358.VAB18032_09230	1.417e-118	385.0	COG1573@1|root,COG1573@2|Bacteria,2GK1I@201174|Actinobacteria,4DAD3@85008|Micromonosporales	201174|Actinobacteria	L	Uracil-DNA glycosylase	udgB	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_1186321_36	1464048.JNZS01000005_gene5515	3.073e-81	275.0	COG1666@1|root,COG1666@2|Bacteria,2IFIU@201174|Actinobacteria,4DA1M@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the UPF0234 family	trpF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
TLS2_k127_1186321_47	222534.KB893727_gene5419	3.122e-42	156.0	COG4118@1|root,COG4118@2|Bacteria,2GQIP@201174|Actinobacteria	201174|Actinobacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS2_k127_1186321_46	222534.KB893727_gene5420	5.178e-52	190.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_1186321_54	1206735.BAGG01000243_gene5877	7.235e-19	93.0	COG0451@1|root,COG0451@2|Bacteria,2GJYY@201174|Actinobacteria	201174|Actinobacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
TLS2_k127_1186321_37	208439.AJAP_31540	3.108e-79	273.0	COG0451@1|root,COG0451@2|Bacteria,2GJYY@201174|Actinobacteria,4E5ZF@85010|Pseudonocardiales	201174|Actinobacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_1186806_8	33876.JNXY01000025_gene5328	1.832e-15	80.0	2DRBI@1|root,33B4D@2|Bacteria,2HUS5@201174|Actinobacteria,4DFWJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1186806_0	479432.Sros_4060	0.0	1324.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2GJKW@201174|Actinobacteria,4EIAC@85012|Streptosporangiales	201174|Actinobacteria	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
TLS2_k127_1186806_1	1463821.JOGR01000012_gene4119	0.0	1316.0	COG3957@1|root,COG3957@2|Bacteria,2GN27@201174|Actinobacteria,4EZCR@85014|Glycomycetales	201174|Actinobacteria	G	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
TLS2_k127_1186806_3	1136417.AZWE01000001_gene3765	4.696e-146	474.0	COG0282@1|root,COG0282@2|Bacteria,2GJAW@201174|Actinobacteria,4D98Q@85008|Micromonosporales	201174|Actinobacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0409	Acetate_kinase
TLS2_k127_1186806_6	512565.AMIS_36460	6.989e-47	189.0	COG2234@1|root,COG2234@2|Bacteria,2GIT0@201174|Actinobacteria,4D9CR@85008|Micromonosporales	201174|Actinobacteria	E	Peptidase family M28	-	-	3.4.11.24	ko:K19702	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	P_proprotein,Peptidase_M28
TLS2_k127_1186806_4	1464048.JNZS01000009_gene5854	1.129e-138	460.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,2GJYH@201174|Actinobacteria,4DADU@85008|Micromonosporales	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,P_proprotein,Peptidase_S8
TLS2_k127_1186806_2	644283.Micau_2382	2.944e-224	696.0	COG2141@1|root,COG2141@2|Bacteria,2GKCU@201174|Actinobacteria,4DABS@85008|Micromonosporales	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_1186806_5	644283.Micau_2383	1.02e-80	274.0	COG0431@1|root,COG0431@2|Bacteria,2IHWU@201174|Actinobacteria,4DCQ8@85008|Micromonosporales	201174|Actinobacteria	S	FMN reductase	ssuE	-	1.5.1.38	ko:K00299	ko00740,ko00920,ko01100,map00740,map00920,map01100	-	R05706,R07210,R10206	RC00126,RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	FMN_red
TLS2_k127_1186806_7	44060.JODL01000006_gene1432	1.346e-28	115.0	2BZ6B@1|root,336KR@2|Bacteria,2IQEV@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1231345_28	219305.MCAG_04512	3.296e-68	235.0	COG1136@1|root,COG1136@2|Bacteria,2GIV7@201174|Actinobacteria,4DC4Q@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_1231345_49	1463864.JOGO01000007_gene676	7.322e-14	73.0	2CHIN@1|root,2ZDG8@2|Bacteria,2GPR5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1231345_13	1136417.AZWE01000041_gene187	2.767e-135	448.0	COG0683@1|root,COG0683@2|Bacteria,2GM00@201174|Actinobacteria,4D8VT@85008|Micromonosporales	201174|Actinobacteria	E	Receptor family ligand binding region	livK	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_1231345_39	33876.JNXY01000025_gene5403	2.265e-38	147.0	2AVAQ@1|root,31M1Y@2|Bacteria,2IMIK@201174|Actinobacteria,4DEQS@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1231345_9	1121385.AQXW01000004_gene1813	4.186e-172	570.0	COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,2GKEU@201174|Actinobacteria,1ZWMH@145357|Dermacoccaceae	201174|Actinobacteria	V	Forkhead associated domain	-	-	-	ko:K01990,ko:K21397	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC_tran,FHA,Yop-YscD_cpl
TLS2_k127_1231345_34	369723.Strop_2588	7.002e-52	193.0	COG5660@1|root,COG5660@2|Bacteria,2IHDZ@201174|Actinobacteria,4DD83@85008|Micromonosporales	201174|Actinobacteria	S	Putative zinc-finger	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_1231345_31	649831.L083_4562	6.005e-58	207.0	COG1595@1|root,COG1595@2|Bacteria,2IHWH@201174|Actinobacteria,4DDE8@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sig10	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_1231345_0	1068978.AMETH_3900	0.0	1153.0	COG1506@1|root,COG1680@1|root,COG1506@2|Bacteria,COG1680@2|Bacteria,2GMMM@201174|Actinobacteria,4DYU4@85010|Pseudonocardiales	201174|Actinobacteria	EV	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,PD40,Peptidase_S9
TLS2_k127_1231345_42	1121946.AUAX01000020_gene3196	5.396e-34	139.0	COG1725@1|root,COG1725@2|Bacteria,2IQEW@201174|Actinobacteria,4DEFY@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	GntR
TLS2_k127_1231345_40	35754.JNYJ01000129_gene4876	3.691e-37	142.0	COG2963@1|root,COG2963@2|Bacteria,2IQ8F@201174|Actinobacteria	201174|Actinobacteria	L	PFAM transposase IS3 IS911 family protein	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
TLS2_k127_1231345_50	1122622.ATWJ01000007_gene1749	5.155e-11	66.0	COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,4FIP2@85021|Intrasporangiaceae	201174|Actinobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
TLS2_k127_1231345_41	561175.KB894093_gene2960	4.824e-36	153.0	2E384@1|root,32Y7U@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K18546	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Trypsin
TLS2_k127_1231345_54	29306.JOBE01000001_gene2623	5.585e-06	55.0	2BBSQ@1|root,325AW@2|Bacteria,2HAF8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1231345_51	1120949.KB903300_gene6157	1.998e-10	61.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4DD18@85008|Micromonosporales	201174|Actinobacteria	L	required for the transposition of insertion element IS2404	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
TLS2_k127_1231345_37	479431.Namu_4492	4.294e-48	177.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_1231345_44	710687.KI912270_gene4803	7.156e-24	109.0	COG0582@1|root,COG0582@2|Bacteria,2GNTJ@201174|Actinobacteria,23FFE@1762|Mycobacteriaceae	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_1231345_32	67267.JNXT01000009_gene640	2.667e-56	206.0	COG0582@1|root,COG0582@2|Bacteria,2GNTJ@201174|Actinobacteria	201174|Actinobacteria	L	PFAM phage integrase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_1231345_23	566461.SSFG_00522	5.491e-100	331.0	COG0500@1|root,COG2226@2|Bacteria,2GKH6@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_1231345_48	1240349.ANGC01000083_gene97	1.474e-15	80.0	COG0582@1|root,COG0582@2|Bacteria,2GNTJ@201174|Actinobacteria,4FWST@85025|Nocardiaceae	201174|Actinobacteria	L	PFAM phage integrase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_1231345_46	644283.Micau_4429	6.716e-19	94.0	COG0789@1|root,COG0789@2|Bacteria,2IFX0@201174|Actinobacteria,4DEZD@85008|Micromonosporales	201174|Actinobacteria	K	MerR, DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_1231345_47	479433.Caci_1996	8.765e-16	90.0	2FHZX@1|root,349SV@2|Bacteria,2H8G7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1231345_43	479433.Caci_1997	3.151e-24	118.0	2FFC8@1|root,3479V@2|Bacteria,2H8FE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1231345_21	35754.JNYJ01000025_gene8874	4.379e-107	355.0	COG0859@1|root,COG0859@2|Bacteria,2GMZG@201174|Actinobacteria,4D8SU@85008|Micromonosporales	201174|Actinobacteria	M	glycosyl transferase, family 9	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TLS2_k127_1231345_45	1054213.HMPREF9946_03065	1.539e-21	104.0	COG1028@1|root,COG1028@2|Bacteria,1P1U4@1224|Proteobacteria	1224|Proteobacteria	IQ	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_1231345_10	1120949.KB903296_gene9528	3.945e-167	538.0	COG0279@1|root,COG0615@1|root,COG2870@1|root,COG0279@2|Bacteria,COG0615@2|Bacteria,COG2870@2|Bacteria,2GKU1@201174|Actinobacteria,4DA1B@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB,SIS_2
TLS2_k127_1231345_26	649831.L083_4594	1.334e-70	246.0	COG0279@1|root,COG0279@2|Bacteria,2IIGW@201174|Actinobacteria	201174|Actinobacteria	G	phosphoheptose isomerase	gmhA	-	2.7.7.71,5.3.1.28	ko:K03271,ko:K15669	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769,R09772	RC00002,RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
TLS2_k127_1231345_11	1136417.AZWE01000003_gene3443	8.032e-162	522.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4DAM2@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyl transferase	-	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_1231345_16	469371.Tbis_2646	9.516e-131	425.0	COG0438@1|root,COG0438@2|Bacteria,2GJUN@201174|Actinobacteria,4DYRA@85010|Pseudonocardiales	201174|Actinobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
TLS2_k127_1231345_4	1246995.AFR_16605	3.145e-199	634.0	COG0241@1|root,COG0859@1|root,COG0241@2|Bacteria,COG0859@2|Bacteria,2GSTW@201174|Actinobacteria,4DBB2@85008|Micromonosporales	201174|Actinobacteria	EM	hydrolase, HAD-superfamily, subfamily IIIA	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,Hydrolase_like
TLS2_k127_1231345_20	649831.L083_4598	9.008e-108	369.0	COG1216@1|root,COG1216@2|Bacteria,2I30N@201174|Actinobacteria,4DHCG@85008|Micromonosporales	201174|Actinobacteria	S	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS2_k127_1231345_3	35754.JNYJ01000025_gene8882	2.237e-271	843.0	COG2192@1|root,COG2192@2|Bacteria,2GJHV@201174|Actinobacteria,4DCD8@85008|Micromonosporales	201174|Actinobacteria	O	Carbamoyltransferase	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TLS2_k127_1231345_33	1068978.AMETH_3406	2.571e-53	193.0	COG4572@1|root,COG4572@2|Bacteria,2IMHQ@201174|Actinobacteria,4E4T3@85010|Pseudonocardiales	201174|Actinobacteria	S	ChaB	chaB	-	-	-	-	-	-	-	-	-	-	-	ChaB,Rho_N
TLS2_k127_1231345_17	644283.Micau_1707	8.163e-127	426.0	COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria,4DAGX@85008|Micromonosporales	201174|Actinobacteria	C	F420-dependent oxidoreductase, g6pdh family	fgd_1	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_1231345_25	1214101.BN159_1905	3.249e-78	273.0	COG0584@1|root,COG0584@2|Bacteria,2I8GW@201174|Actinobacteria	201174|Actinobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS2_k127_1231345_29	1137269.AZWL01000002_gene6446	6.395e-68	236.0	COG0522@1|root,COG0522@2|Bacteria,2GIRX@201174|Actinobacteria	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
TLS2_k127_1231345_38	1463903.JOIZ01000037_gene5469	5.687e-43	163.0	COG2146@1|root,COG2146@2|Bacteria,2I1BQ@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231,Rieske
TLS2_k127_1231345_19	1121362.A605_01190	4.445e-113	374.0	COG0300@1|root,COG0300@2|Bacteria,2IIVW@201174|Actinobacteria,22K88@1653|Corynebacteriaceae	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_1231345_14	1122602.ATXP01000012_gene1763	5.297e-134	455.0	28J3E@1|root,2Z8ZN@2|Bacteria,2IADA@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1231345_27	298655.KI912267_gene7284	1.456e-68	258.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2GIV0@201174|Actinobacteria,4EX1X@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
TLS2_k127_1231345_22	36809.MAB_0445	5.025e-107	365.0	COG4422@1|root,COG4422@2|Bacteria,2HKVP@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF5131)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1231345_18	29306.JOBE01000032_gene5920	1.303e-126	408.0	COG4422@1|root,COG4422@2|Bacteria,2GJHQ@201174|Actinobacteria	201174|Actinobacteria	S	PFAM phage	-	-	-	-	-	-	-	-	-	-	-	-	DUF5131
TLS2_k127_1231345_53	58344.JOEL01000010_gene5760	9.8e-07	53.0	COG1426@1|root,COG1426@2|Bacteria,2IQH6@201174|Actinobacteria	201174|Actinobacteria	K	PFAM Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
TLS2_k127_1231345_8	1283283.ATXA01000004_gene4260	1.376e-178	574.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4ES4U@85013|Frankiales	201174|Actinobacteria	L	DEAD DEAH box helicase domain protein	rhlE1	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
TLS2_k127_1231345_52	1121017.AUFG01000007_gene1240	3.307e-08	55.0	2BRPR@1|root,32KPC@2|Bacteria,2HBY1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1231345_5	219305.MCAG_02983	1.23e-197	621.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4D8EX@85008|Micromonosporales	201174|Actinobacteria	C	dehydrogenase, E1 component	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS2_k127_1231345_7	644283.Micau_0148	4.688e-186	586.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4DA2N@85008|Micromonosporales	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_1231345_6	390989.JOEG01000004_gene3765	7.656e-187	593.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria,4D9AD@85008|Micromonosporales	201174|Actinobacteria	C	of components of various dehydrogenase complexes	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_1231345_55	35754.JNYJ01000027_gene6201	0.0004299	53.0	COG0443@1|root,COG0443@2|Bacteria,2GMNN@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the heat shock protein 70 family	hscA	-	-	-	-	-	-	-	-	-	-	-	HSP70
TLS2_k127_1231345_1	1464048.JNZS01000009_gene5907	6.173e-298	924.0	COG0526@1|root,COG0526@2|Bacteria,2GKDT@201174|Actinobacteria,4D9UR@85008|Micromonosporales	201174|Actinobacteria	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,NHL,Thioredoxin_8
TLS2_k127_1231345_12	134676.ACPL_8331	5.048e-149	481.0	COG0303@1|root,COG0303@2|Bacteria,2GP1B@201174|Actinobacteria,4DBSX@85008|Micromonosporales	201174|Actinobacteria	H	Probable molybdopterin binding domain	moaA2	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS2_k127_1231345_30	649831.L083_8162	1.897e-61	217.0	COG0314@1|root,COG0314@2|Bacteria,2IQ9F@201174|Actinobacteria,4DD4C@85008|Micromonosporales	201174|Actinobacteria	H	Molybdopterin biosynthesis MoaE protein	moaE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
TLS2_k127_1231345_24	1449048.JQKU01000022_gene2716	1.28e-97	329.0	COG0451@1|root,COG0451@2|Bacteria,2HS3E@201174|Actinobacteria,23D4Q@1762|Mycobacteriaceae	201174|Actinobacteria	GM	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_1231345_35	1121946.AUAX01000019_gene7701	7.03e-52	188.0	COG2062@1|root,COG2062@2|Bacteria,2GJ0I@201174|Actinobacteria,4DEGH@85008|Micromonosporales	201174|Actinobacteria	T	phosphohistidine phosphatase, SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
TLS2_k127_1231345_36	1123024.AUII01000010_gene754	2.041e-48	180.0	COG4113@1|root,COG4113@2|Bacteria,2GR4U@201174|Actinobacteria,4E5QD@85010|Pseudonocardiales	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_1231345_2	356851.JOAN01000004_gene961	3.551e-288	895.0	COG1960@1|root,COG1960@2|Bacteria,2GJIB@201174|Actinobacteria,4DB5B@85008|Micromonosporales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase N terminal	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,AcylCoA_DH_N
TLS2_k127_1231345_15	1246995.AFR_00420	4.579e-131	421.0	COG2208@1|root,COG2208@2|Bacteria,2GK3Y@201174|Actinobacteria,4D97T@85008|Micromonosporales	201174|Actinobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
TLS2_k127_1255237_33	1246995.AFR_01255	2.133e-34	132.0	COG1770@1|root,COG1770@2|Bacteria,2GNA9@201174|Actinobacteria,4DAD5@85008|Micromonosporales	201174|Actinobacteria	E	Oligopeptidase b	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_1255237_5	219305.MCAG_03143	2.051e-200	628.0	COG0031@1|root,COG0031@2|Bacteria,2GNE4@201174|Actinobacteria,4D8D3@85008|Micromonosporales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_1255237_1	298655.KI912266_gene2098	3.06e-282	903.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4EU8G@85013|Frankiales	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
TLS2_k127_1255237_36	452863.Achl_1039	3.247e-15	89.0	COG3631@1|root,COG3631@2|Bacteria,2IFBE@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
TLS2_k127_1255237_6	1289387.AUKW01000009_gene4242	2.418e-197	624.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_1255237_14	1120950.KB892790_gene2123	2.014e-113	372.0	COG0639@1|root,COG0639@2|Bacteria,2HFPY@201174|Actinobacteria,4DTRW@85009|Propionibacteriales	201174|Actinobacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
TLS2_k127_1255237_37	1121933.AUHH01000052_gene1028	9.435e-13	78.0	COG3554@1|root,COG3554@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K09957	-	-	-	-	ko00000	-	-	-	Glycolipid_bind
TLS2_k127_1255237_10	263358.VAB18032_02565	3.453e-167	532.0	COG0079@1|root,COG0079@2|Bacteria,2GJXS@201174|Actinobacteria,4D8M2@85008|Micromonosporales	201174|Actinobacteria	E	May catalyze the transamination reaction in phenylalanine biosynthesis	pat	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_1255237_19	219305.MCAG_02375	6.432e-92	311.0	COG1714@1|root,COG1714@2|Bacteria,2GN0D@201174|Actinobacteria,4DCSS@85008|Micromonosporales	201174|Actinobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,RDD
TLS2_k127_1255237_3	391037.Sare_4680	1.933e-212	665.0	COG3185@1|root,COG3185@2|Bacteria,2GNF0@201174|Actinobacteria,4DAGM@85008|Micromonosporales	201174|Actinobacteria	E	4-hydroxyphenylpyruvate dioxygenase	-	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
TLS2_k127_1255237_26	35754.JNYJ01000036_gene3691	2.922e-73	249.0	COG1522@1|root,COG1522@2|Bacteria,2H7NM@201174|Actinobacteria,4DDDF@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS2_k127_1255237_23	1464048.JNZS01000002_gene469	7.559e-84	295.0	COG1520@1|root,COG1520@2|Bacteria,2I8VP@201174|Actinobacteria,4DC48@85008|Micromonosporales	201174|Actinobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_1255237_0	1121946.AUAX01000048_gene3636	3.71e-314	966.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,2GK6D@201174|Actinobacteria,4DBIX@85008|Micromonosporales	201174|Actinobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumB	-	4.2.1.2,4.2.1.32	ko:K01676,ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
TLS2_k127_1255237_39	1121926.AXWO01000019_gene1849	2.835e-05	50.0	COG1373@1|root,COG1373@2|Bacteria,2GK1Q@201174|Actinobacteria,4EZUN@85014|Glycomycetales	201174|Actinobacteria	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
TLS2_k127_1255237_38	1121926.AXWO01000019_gene1849	6.281e-10	69.0	COG1373@1|root,COG1373@2|Bacteria,2GK1Q@201174|Actinobacteria,4EZUN@85014|Glycomycetales	201174|Actinobacteria	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
TLS2_k127_1255237_25	1206731.BAGB01000174_gene1924	4.725e-74	257.0	29G7B@1|root,30354@2|Bacteria,2IIW0@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4184)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4184
TLS2_k127_1255237_8	1122182.KB903835_gene4677	9.048e-194	615.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria,4DADQ@85008|Micromonosporales	201174|Actinobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
TLS2_k127_1255237_18	219305.MCAG_02354	4.103e-99	334.0	COG2852@1|root,COG2852@2|Bacteria,2GNZQ@201174|Actinobacteria,4DC9G@85008|Micromonosporales	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
TLS2_k127_1255237_4	543632.JOJL01000029_gene3619	2.208e-207	651.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4DAD8@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TLS2_k127_1255237_15	391037.Sare_5035	4.537e-111	366.0	COG0561@1|root,COG0561@2|Bacteria,2GP42@201174|Actinobacteria,4D8KR@85008|Micromonosporales	201174|Actinobacteria	S	Had-superfamily hydrolase, subfamily iib	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
TLS2_k127_1255237_29	644283.Micau_6225	2.629e-63	219.0	COG1764@1|root,COG1764@2|Bacteria,2IFFB@201174|Actinobacteria,4DCYH@85008|Micromonosporales	201174|Actinobacteria	O	OsmC-like protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
TLS2_k127_1255237_30	33876.JNXY01000037_gene8017	3.688e-56	201.0	COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria,4DEMB@85008|Micromonosporales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
TLS2_k127_1255237_11	1150864.MILUP08_30145	1.708e-156	501.0	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4D8DX@85008|Micromonosporales	201174|Actinobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
TLS2_k127_1255237_35	263358.VAB18032_04080	1.496e-21	101.0	2AYID@1|root,31QN4@2|Bacteria,2ISCE@201174|Actinobacteria,4DFGW@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1255237_34	543632.JOJL01000029_gene3611	1.994e-27	120.0	2EIMF@1|root,33CCQ@2|Bacteria,2II5C@201174|Actinobacteria,4DDV4@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1255237_28	219305.MCAG_02791	8.44e-66	233.0	2CNM1@1|root,32SHB@2|Bacteria,2HU6Z@201174|Actinobacteria,4DCCA@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1255237_7	219305.MCAG_02790	7.514e-194	612.0	COG2235@1|root,COG2235@2|Bacteria,2GJTR@201174|Actinobacteria,4D8RS@85008|Micromonosporales	201174|Actinobacteria	E	Arginine	arcA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
TLS2_k127_1255237_13	33876.JNXY01000037_gene8010	3.705e-121	398.0	COG3012@1|root,COG3012@2|Bacteria,2GJ7F@201174|Actinobacteria,4D8NV@85008|Micromonosporales	201174|Actinobacteria	S	SEC-C motif	-	-	-	-	-	-	-	-	-	-	-	-	SEC-C
TLS2_k127_1255237_31	1121272.KB903261_gene6095	1.031e-51	191.0	COG2172@1|root,COG2172@2|Bacteria,2I43M@201174|Actinobacteria,4DEA0@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
TLS2_k127_1255237_22	644283.Micau_6215	1.197e-84	287.0	COG0642@1|root,COG2205@2|Bacteria,2GMB9@201174|Actinobacteria,4D917@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K18350	ko01502,ko02020,map01502,map02020	M00652,M00657	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4
TLS2_k127_1255237_17	1150864.MILUP08_30136	1.752e-105	351.0	COG0584@1|root,COG0584@2|Bacteria,2GMMS@201174|Actinobacteria,4DCW7@85008|Micromonosporales	201174|Actinobacteria	C	glycerophosphoryl diester phosphodiesterase	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS2_k127_1255237_32	1869.MB27_37480	1.402e-44	163.0	COG0607@1|root,COG0607@2|Bacteria,2IQIP@201174|Actinobacteria,4DEF0@85008|Micromonosporales	201174|Actinobacteria	P	Rhodanese Homology Domain	glpE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_1255237_20	33876.JNXY01000037_gene8006	1.967e-91	320.0	COG1316@1|root,COG1316@2|Bacteria,2IBA9@201174|Actinobacteria,4DBDH@85008|Micromonosporales	201174|Actinobacteria	K	cell envelope-related function transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
TLS2_k127_1255237_16	1464048.JNZS01000009_gene5706	3.66e-108	363.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4D9UN@85008|Micromonosporales	201174|Actinobacteria	K	cell envelope-related function transcriptional attenuator, LytR CpsA family	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
TLS2_k127_1255237_9	219305.MCAG_02781	7.264e-170	537.0	COG0451@1|root,COG0451@2|Bacteria,2I2EG@201174|Actinobacteria,4D8KH@85008|Micromonosporales	201174|Actinobacteria	GM	Nad-dependent epimerase dehydratase	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS2_k127_1255237_27	263358.VAB18032_04005	3.148e-68	236.0	COG1853@1|root,COG1853@2|Bacteria,2IP6R@201174|Actinobacteria,4DCXF@85008|Micromonosporales	201174|Actinobacteria	S	flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TLS2_k127_1255237_12	219305.MCAG_02773	9.447e-149	494.0	2BWH2@1|root,2Z89R@2|Bacteria,2GMNW@201174|Actinobacteria,4D97R@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_1255237_21	76636.JOEC01000001_gene209	1.053e-87	296.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4FKRK@85023|Microbacteriaceae	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	natA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1255237_2	391037.Sare_5006	1.501e-231	728.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,4DC69@85008|Micromonosporales	201174|Actinobacteria	M	Undecaprenyl-phosphate galactose phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS2_k127_1255237_24	290397.Adeh_3929	5.611e-80	273.0	COG0266@1|root,COG0266@2|Bacteria,1MVHK@1224|Proteobacteria,43791@68525|delta/epsilon subdivisions,2X9X0@28221|Deltaproteobacteria,2YZTI@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the FPG family	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_137781_27	219305.MCAG_03488	4.641e-106	354.0	COG0566@1|root,COG0566@2|Bacteria,2GM1A@201174|Actinobacteria,4DB7B@85008|Micromonosporales	201174|Actinobacteria	J	tRNA rRNA methyltransferase	trmH	-	2.1.1.34	ko:K00556	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
TLS2_k127_137781_45	1121946.AUAX01000005_gene5295	4.638e-31	131.0	2AYS8@1|root,31QXE@2|Bacteria,2IT4P@201174|Actinobacteria,4DF45@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_137781_42	512565.AMIS_69500	3.764e-41	159.0	2ECMH@1|root,336JI@2|Bacteria,2IQU7@201174|Actinobacteria,4DF0Q@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_137781_26	1246995.AFR_37795	5.071e-112	368.0	28PI0@1|root,2ZC87@2|Bacteria,2IDWK@201174|Actinobacteria,4DACP@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VKG_Carbox
TLS2_k127_137781_41	1150864.MILUP08_40778	9.269e-45	165.0	COG3011@1|root,COG3011@2|Bacteria,2IMHW@201174|Actinobacteria,4DEVM@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
TLS2_k127_137781_37	1136417.AZWE01000010_gene2878	1.412e-56	199.0	COG3118@1|root,COG3118@2|Bacteria,2I2FB@201174|Actinobacteria,4DDMQ@85008|Micromonosporales	201174|Actinobacteria	O	Belongs to the thioredoxin family	trxA	-	1.8.1.8	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin
TLS2_k127_137781_13	263358.VAB18032_08175	1.317e-159	509.0	COG1533@1|root,COG1533@2|Bacteria,2GM31@201174|Actinobacteria,4D8JM@85008|Micromonosporales	201174|Actinobacteria	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_137781_47	543632.JOJL01000037_gene6373	8.67e-27	113.0	2DYMY@1|root,34AD9@2|Bacteria,2I408@201174|Actinobacteria,4DFMF@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
TLS2_k127_137781_48	1121946.AUAX01000005_gene5289	1.573e-26	113.0	2DYMY@1|root,34AD9@2|Bacteria,2I408@201174|Actinobacteria,4DFMF@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
TLS2_k127_137781_21	543632.JOJL01000037_gene6372	1.587e-127	413.0	COG1028@1|root,COG1028@2|Bacteria,2GKW9@201174|Actinobacteria,4D9G6@85008|Micromonosporales	201174|Actinobacteria	IQ	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_137781_49	1150864.MILUP08_40771	5.189e-26	112.0	2EGCD@1|root,33A46@2|Bacteria,2HUKV@201174|Actinobacteria,4DFF1@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
TLS2_k127_137781_28	1150864.MILUP08_40767	1.923e-99	332.0	COG0697@1|root,COG0697@2|Bacteria,2I198@201174|Actinobacteria,4D9U8@85008|Micromonosporales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_137781_38	1464048.JNZS01000004_gene1448	2.773e-52	197.0	2E6WZ@1|root,331GF@2|Bacteria,2IFC6@201174|Actinobacteria,4DDCT@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_137781_7	1121946.AUAX01000003_gene1538	8.506e-185	586.0	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,4D8R7@85008|Micromonosporales	201174|Actinobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0008150,GO:0040007	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
TLS2_k127_137781_44	369723.Strop_0148	1.095e-34	136.0	COG0393@1|root,COG0393@2|Bacteria,2IHTU@201174|Actinobacteria,4DG52@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
TLS2_k127_137781_20	263358.VAB18032_29911	3.355e-128	422.0	COG0438@1|root,COG0438@2|Bacteria,2I005@201174|Actinobacteria,4DAQI@85008|Micromonosporales	201174|Actinobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_137781_30	219305.MCAG_03710	2.586e-85	292.0	28PSZ@1|root,2ZCEC@2|Bacteria,2GMRM@201174|Actinobacteria,4DC82@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_137781_16	35754.JNYJ01000007_gene2787	1.699e-148	479.0	COG1322@1|root,COG1322@2|Bacteria,2GP4U@201174|Actinobacteria,4DA17@85008|Micromonosporales	201174|Actinobacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
TLS2_k127_137781_11	512565.AMIS_74230	2.381e-161	515.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4DBHE@85008|Micromonosporales	201174|Actinobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
TLS2_k127_137781_32	749414.SBI_04893	3.533e-83	289.0	COG1309@1|root,COG1309@2|Bacteria,2GQBQ@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
TLS2_k127_137781_14	1120950.KB892778_gene1026	1.954e-153	491.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DPWK@85009|Propionibacteriales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_137781_17	1120950.KB892778_gene1027	1.086e-143	462.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,4DQ35@85009|Propionibacteriales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_137781_6	1150864.MILUP08_40968	4.249e-191	604.0	COG1570@1|root,COG1570@2|Bacteria,2GJAS@201174|Actinobacteria,4DB5X@85008|Micromonosporales	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TLS2_k127_137781_55	649831.L083_4822	2.407e-07	61.0	COG4124@1|root,COG4124@2|Bacteria,2GMW5@201174|Actinobacteria,4D8ZF@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 26 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_26
TLS2_k127_137781_29	35754.JNYJ01000004_gene5869	2.229e-92	319.0	COG0510@1|root,COG0510@2|Bacteria,2IC6A@201174|Actinobacteria,4DA6F@85008|Micromonosporales	201174|Actinobacteria	M	thiamine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_137781_22	512565.AMIS_7290	7.25e-120	392.0	COG4424@1|root,COG4424@2|Bacteria,2HETZ@201174|Actinobacteria,4DB7H@85008|Micromonosporales	201174|Actinobacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
TLS2_k127_137781_19	1869.MB27_02815	8e-129	422.0	COG0463@1|root,COG0463@2|Bacteria,2I0YU@201174|Actinobacteria,4D8W1@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_137781_2	1121946.AUAX01000026_gene6269	4.217e-282	879.0	COG1012@1|root,COG1012@2|Bacteria,2GJZE@201174|Actinobacteria,4D9DV@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	putA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS2_k127_137781_40	263358.VAB18032_09780	7.213e-46	180.0	290HW@1|root,2ZN6T@2|Bacteria,2I9BP@201174|Actinobacteria,4DBCN@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_137781_46	1150864.MILUP08_41090	4.761e-27	115.0	2DRWJ@1|root,32URV@2|Bacteria,2IFAY@201174|Actinobacteria,4DDI5@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_137781_50	1464048.JNZS01000008_gene6291	9.157e-24	109.0	2EUNN@1|root,33N4H@2|Bacteria,2IN6S@201174|Actinobacteria,4DE0R@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_137781_53	1380393.JHVP01000013_gene3434	1.635e-11	70.0	COG1695@1|root,COG1695@2|Bacteria,2GRHC@201174|Actinobacteria,4EWUP@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
TLS2_k127_137781_0	644283.Micau_1015	0.0	1412.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4D8X2@85008|Micromonosporales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TLS2_k127_137781_31	1246995.AFR_05785	2.087e-84	285.0	COG1544@1|root,COG1544@2|Bacteria,2GMYF@201174|Actinobacteria,4DACB@85008|Micromonosporales	201174|Actinobacteria	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
TLS2_k127_137781_35	219305.MCAG_03979	5.899e-59	215.0	COG1040@1|root,COG1040@2|Bacteria,2I9PA@201174|Actinobacteria,4DBKF@85008|Micromonosporales	201174|Actinobacteria	S	phosphoribosyltransferase	pyrE_1	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
TLS2_k127_137781_33	369723.Strop_0969	2.76e-75	275.0	COG5401@1|root,COG5401@2|Bacteria,2HTXI@201174|Actinobacteria,4D9AZ@85008|Micromonosporales	201174|Actinobacteria	S	Lipoprotein LpqB beta-propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad1
TLS2_k127_137781_8	644283.Micau_1009	2.471e-179	579.0	COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria,2GJ2D@201174|Actinobacteria,4DAFE@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	mtrB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.7.13.3	ko:K07636,ko:K07654	ko02020,map02020	M00434,M00461	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_137781_18	649831.L083_1173	6.456e-132	428.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,4DCHC@85008|Micromonosporales	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	mtrA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016310,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K07670	ko02020,map02020	M00461	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_137781_15	1081644.IMCC13023_05090	2.316e-149	495.0	COG1132@1|root,COG1132@2|Bacteria,2GJTA@201174|Actinobacteria,4FM09@85023|Microbacteriaceae	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_137781_9	35754.JNYJ01000050_gene7939	6.05e-179	566.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4D8FI@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS2_k127_137781_12	35754.JNYJ01000050_gene7940	8.333e-161	514.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4D8DM@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_137781_23	446468.Ndas_4533	1.777e-115	380.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria	201174|Actinobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_137781_25	1245475.ANAE01000123_gene365	3.096e-112	373.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria	201174|Actinobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_137781_5	269800.Tfu_1633	2.054e-197	632.0	COG0747@1|root,COG0747@2|Bacteria,2GJ9N@201174|Actinobacteria,4EMIY@85012|Streptosporangiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_137781_3	1121946.AUAX01000026_gene6293	6.105e-278	858.0	COG0499@1|root,COG0499@2|Bacteria,2GK2Q@201174|Actinobacteria,4DA79@85008|Micromonosporales	201174|Actinobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS2_k127_137781_24	644283.Micau_0996	1.497e-113	377.0	COG1482@1|root,COG1482@2|Bacteria,2GJXC@201174|Actinobacteria,4D8SI@85008|Micromonosporales	201174|Actinobacteria	G	isomerase	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
TLS2_k127_137781_10	1464048.JNZS01000008_gene6307	4.256e-168	538.0	COG1737@1|root,COG1737@2|Bacteria,2GMG0@201174|Actinobacteria,4D9NK@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial phospho-glucose isomerase C-terminal SIS domain	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	bact-PGI_C
TLS2_k127_137781_51	1122182.KB903813_gene2663	8.635e-23	98.0	COG2835@1|root,COG2835@2|Bacteria,2HUT4@201174|Actinobacteria,4DFYF@85008|Micromonosporales	201174|Actinobacteria	S	Trm112p-like protein	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
TLS2_k127_137781_4	1136417.AZWE01000007_gene1985	3.06e-206	652.0	COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,4D9XK@85008|Micromonosporales	201174|Actinobacteria	G	phosphomannomutase	manB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_137781_43	543632.JOJL01000003_gene8597	2.868e-40	155.0	2C7XW@1|root,32RR4@2|Bacteria,2IQ5R@201174|Actinobacteria,4DDQP@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3499)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3499
TLS2_k127_137781_34	512565.AMIS_8580	2.667e-60	216.0	COG3824@1|root,COG3824@2|Bacteria,2IS6W@201174|Actinobacteria,4DCTU@85008|Micromonosporales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
TLS2_k127_137781_39	1121946.AUAX01000026_gene6315	6.666e-48	173.0	2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,4DFEX@85008|Micromonosporales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB2	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS2_k127_137781_1	1150864.MILUP08_41044	0.0	1338.0	COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4DBWV@85008|Micromonosporales	201174|Actinobacteria	H	FO synthase	fbiC	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
TLS2_k127_137781_52	1122182.KB903813_gene2654	2.766e-19	100.0	COG3667@1|root,COG3667@2|Bacteria,2IHUC@201174|Actinobacteria,4DDBI@85008|Micromonosporales	201174|Actinobacteria	P	copper resistance	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_137781_36	390989.JOEG01000005_gene2029	5.808e-58	202.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria,4D8GQ@85008|Micromonosporales	201174|Actinobacteria	S	LPPG FO 2-phospho-L-lactate transferase	cofD	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0043743,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
TLS2_k127_1444438_1	1869.MB27_38505	2.809e-271	849.0	COG0747@1|root,COG0747@2|Bacteria,2GJXH@201174|Actinobacteria,4DAE2@85008|Micromonosporales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_1444438_13	479435.Kfla_3794	1.987e-143	463.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4DQ7K@85009|Propionibacteriales	201174|Actinobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	appC	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
TLS2_k127_1444438_20	298655.KI912266_gene2101	1.83e-85	293.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	LysM,Polysacc_deac_1
TLS2_k127_1444438_23	471853.Bcav_4096	4.685e-22	106.0	2CANP@1|root,33WUD@2|Bacteria,2H5PF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1444438_3	1121946.AUAX01000024_gene7672	9.639e-228	720.0	COG3629@1|root,COG3629@2|Bacteria,2H1NS@201174|Actinobacteria,4DMFG@85008|Micromonosporales	201174|Actinobacteria	K	sarp family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,NB-ARC,Trans_reg_C
TLS2_k127_1444438_11	67352.JODS01000033_gene7734	1.308e-151	496.0	COG1020@1|root,COG1020@2|Bacteria,2H909@201174|Actinobacteria	201174|Actinobacteria	Q	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,PP-binding
TLS2_k127_1444438_24	1121946.AUAX01000024_gene7670	8.118e-22	97.0	COG1020@1|root,COG1020@2|Bacteria,2GT4Z@201174|Actinobacteria	201174|Actinobacteria	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
TLS2_k127_1444438_6	1121946.AUAX01000024_gene7669	3.302e-186	592.0	COG1231@1|root,COG1231@2|Bacteria,2GK23@201174|Actinobacteria,4DD66@85008|Micromonosporales	201174|Actinobacteria	E	Flavin containing amine oxidoreductase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS2_k127_1444438_0	981369.JQMJ01000004_gene541	9.343e-288	898.0	COG0318@1|root,COG0318@2|Bacteria,2GJI9@201174|Actinobacteria,2NIBR@228398|Streptacidiphilus	201174|Actinobacteria	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_1444438_16	1121946.AUAX01000024_gene7667	1.512e-132	427.0	28HKZ@1|root,2Z7VP@2|Bacteria,2IANB@201174|Actinobacteria,4DB6K@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3050)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3050
TLS2_k127_1444438_18	1121946.AUAX01000024_gene7666	1.103e-97	345.0	COG4221@1|root,COG4221@2|Bacteria,2GRRV@201174|Actinobacteria,4DCTS@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_1444438_8	1121946.AUAX01000024_gene7665	9.672e-173	554.0	COG0477@1|root,COG2814@2|Bacteria,2IEWQ@201174|Actinobacteria	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_1444438_10	1121946.AUAX01000024_gene7664	4.93e-158	509.0	COG1541@1|root,COG1541@2|Bacteria,2IH2W@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding
TLS2_k127_1444438_14	1121946.AUAX01000024_gene7663	1.08e-135	441.0	COG0189@1|root,COG0189@2|Bacteria,2H24F@201174|Actinobacteria,4DKRJ@85008|Micromonosporales	201174|Actinobacteria	HJ	RimK-like ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	GSH-S_ATP,RimK
TLS2_k127_1444438_22	1463901.JOIY01000014_gene5796	6.589e-39	151.0	COG2050@1|root,COG2050@2|Bacteria,2IKWI@201174|Actinobacteria	201174|Actinobacteria	Q	phenylacetic acid degradation protein	paaI	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
TLS2_k127_1444438_19	1380390.JIAT01000011_gene2851	2.155e-95	324.0	COG1171@1|root,COG1171@2|Bacteria,2I8ZW@201174|Actinobacteria,4CQ5T@84995|Rubrobacteria	84995|Rubrobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.15	ko:K01751	-	-	-	-	ko00000,ko01000	-	-	-	PALP
TLS2_k127_1444438_7	2002.JOEQ01000010_gene6165	1.949e-178	576.0	COG2508@1|root,COG2508@2|Bacteria,2GJWJ@201174|Actinobacteria	201174|Actinobacteria	QT	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
TLS2_k127_1444438_5	2002.JOEQ01000010_gene6164	2.533e-213	674.0	COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria,4EFRQ@85012|Streptosporangiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_1444438_15	2002.JOEQ01000010_gene6163	5.024e-135	440.0	COG0601@1|root,COG0601@2|Bacteria,2GJFF@201174|Actinobacteria,4EHU9@85012|Streptosporangiales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_1444438_2	2002.JOEQ01000010_gene6162	2.447e-267	846.0	COG0444@1|root,COG1173@1|root,COG0444@2|Bacteria,COG1173@2|Bacteria,2GIXV@201174|Actinobacteria,4EFFP@85012|Streptosporangiales	201174|Actinobacteria	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,BPD_transp_1,oligo_HPY
TLS2_k127_1444438_21	1169154.KB897781_gene5448	1.604e-83	288.0	COG4608@1|root,COG4608@2|Bacteria,2HMST@201174|Actinobacteria	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
TLS2_k127_1444438_12	2002.JOEQ01000010_gene6160	5.516e-144	466.0	COG3616@1|root,COG3616@2|Bacteria,2GK0N@201174|Actinobacteria,4EPEB@85012|Streptosporangiales	201174|Actinobacteria	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
TLS2_k127_1444438_9	479432.Sros_3298	1.074e-167	549.0	COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria,4EHY7@85012|Streptosporangiales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	3.5.1.81,3.5.2.3	ko:K01465,ko:K06015	ko00240,ko01100,map00240,map01100	M00051	R01993,R02192	RC00064,RC00328,RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
TLS2_k127_1444438_4	2002.JOEQ01000010_gene6159	1.116e-225	712.0	COG1680@1|root,COG1680@2|Bacteria,2GNNF@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
TLS2_k127_1444438_17	1121946.AUAX01000019_gene7687	1.712e-108	363.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4DBUA@85008|Micromonosporales	201174|Actinobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
TLS2_k127_1444438_25	40571.JOEA01000021_gene6880	2.099e-07	53.0	COG1961@1|root,COG1961@2|Bacteria,2GNGI@201174|Actinobacteria,4E13I@85010|Pseudonocardiales	201174|Actinobacteria	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_1528247_7	33876.JNXY01000031_gene3068	1.614e-71	250.0	COG3346@1|root,COG3346@2|Bacteria,2GR90@201174|Actinobacteria,4D9B8@85008|Micromonosporales	201174|Actinobacteria	S	SURF1-like protein	-	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	SURF1
TLS2_k127_1528247_6	1121272.KB903251_gene780	9.085e-80	273.0	COG1670@1|root,COG1670@2|Bacteria,2GNYE@201174|Actinobacteria,4DD1Q@85008|Micromonosporales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_1528247_1	1121272.KB903251_gene781	2.119e-285	893.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4DAUG@85008|Micromonosporales	201174|Actinobacteria	M	glycosyl transferase family	pon1	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
TLS2_k127_1528247_3	644283.Micau_4958	3.991e-171	547.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,2GK3B@201174|Actinobacteria,4D8QN@85008|Micromonosporales	201174|Actinobacteria	H	Uroporphyrin-III C-methyltransferase	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,TP_methylase
TLS2_k127_1528247_8	1122182.KB903833_gene5685	4.336e-67	237.0	COG1877@1|root,COG3387@1|root,COG1877@2|Bacteria,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,4D9PM@85008|Micromonosporales	201174|Actinobacteria	G	Trehalose-phosphatase	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_15,Trehalose_PPase
TLS2_k127_1528247_2	33876.JNXY01000031_gene3076	5.78e-247	773.0	COG0380@1|root,COG0380@2|Bacteria,2GMX7@201174|Actinobacteria,4D9IT@85008|Micromonosporales	201174|Actinobacteria	G	Glycosyltransferase family 20	otsA	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
TLS2_k127_1528247_12	134676.ACPL_6775	4.431e-50	203.0	COG5651@1|root,COG5651@2|Bacteria,2I57Z@201174|Actinobacteria,4DMKV@85008|Micromonosporales	2|Bacteria	N	PPE family	-	-	-	-	-	-	-	-	-	-	-	-	PPE
TLS2_k127_1528247_0	391037.Sare_3917	0.0	998.0	COG0488@1|root,COG0488@2|Bacteria,2GKBQ@201174|Actinobacteria,4D9H1@85008|Micromonosporales	201174|Actinobacteria	S	ABC transporter	yjjK	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
TLS2_k127_1528247_11	543632.JOJL01000023_gene1778	3.371e-64	228.0	2DNM1@1|root,32Y20@2|Bacteria,2IIJ1@201174|Actinobacteria,4DC8Q@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1528247_4	1122182.KB903838_gene4100	6.168e-142	458.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4D8FF@85008|Micromonosporales	201174|Actinobacteria	V	Daunorubicin resistance abc transporter atpase subunit	-	-	-	ko:K01990,ko:K18232	ko02010,map02010	M00254,M00634	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	3.A.1,3.A.1.105.2	-	-	ABC_tran,DUF4162
TLS2_k127_1528247_5	1122182.KB903838_gene4101	3.139e-107	354.0	COG0842@1|root,COG0842@2|Bacteria,2I5GM@201174|Actinobacteria,4DB6R@85008|Micromonosporales	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992,ko:K18233	ko02010,map02010	M00254,M00634	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	3.A.1,3.A.1.105.2	-	-	ABC2_membrane
TLS2_k127_1528247_9	1121946.AUAX01000014_gene1086	9.513e-67	238.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria,4DDYY@85008|Micromonosporales	201174|Actinobacteria	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
TLS2_k127_1528247_10	1394178.AWOO02000041_gene8777	3.29e-64	226.0	COG1670@1|root,COG1670@2|Bacteria,2IQW2@201174|Actinobacteria,4EJRW@85012|Streptosporangiales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006104,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_1701794_9	219305.MCAG_00213	2.489e-69	240.0	2C1XE@1|root,301BZ@2|Bacteria,2IGAE@201174|Actinobacteria,4DCZU@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1701794_8	369723.Strop_2703	9.68e-82	284.0	COG2128@1|root,COG2128@2|Bacteria,2ICI6@201174|Actinobacteria,4DD2S@85008|Micromonosporales	201174|Actinobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_1701794_14	1123023.JIAI01000002_gene5243	8.425e-44	165.0	COG1733@1|root,COG1733@2|Bacteria,2GMQG@201174|Actinobacteria,4EC0S@85010|Pseudonocardiales	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS2_k127_1701794_1	369723.Strop_2704	6.649e-291	902.0	COG2303@1|root,COG2303@2|Bacteria,2GNHC@201174|Actinobacteria,4DC50@85008|Micromonosporales	201174|Actinobacteria	E	GMC oxidoreductase	-	-	1.1.1.400	ko:K20927,ko:K21166	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_1701794_10	479432.Sros_6993	4.333e-69	241.0	2D8S2@1|root,32TRU@2|Bacteria,2IJ1T@201174|Actinobacteria,4EJK8@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	ko:K21165	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002	-	-	-	-
TLS2_k127_1701794_16	219305.MCAG_05567	1.453e-29	128.0	COG2197@1|root,COG2197@2|Bacteria,2GR77@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_1701794_12	443255.SCLAV_p1354	1.493e-56	208.0	COG2207@1|root,COG2207@2|Bacteria,2IH33@201174|Actinobacteria	201174|Actinobacteria	K	PFAM helix-turn-helix- domain containing protein, AraC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC
TLS2_k127_1701794_15	882083.SacmaDRAFT_4555	1.499e-36	144.0	COG2207@1|root,COG2207@2|Bacteria,2IH33@201174|Actinobacteria,4E3TS@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix proteins, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC
TLS2_k127_1701794_3	1150864.MILUP08_41998	4.658e-162	523.0	COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria,4DASM@85008|Micromonosporales	201174|Actinobacteria	C	cytochrome P450	-	-	-	ko:K21164	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002	-	-	-	p450
TLS2_k127_1701794_13	566461.SSFG_07711	4.753e-51	192.0	COG1853@1|root,COG1853@2|Bacteria,2GMPH@201174|Actinobacteria	201174|Actinobacteria	K	PFAM flavin reductase domain protein, FMN-binding	-	-	-	ko:K21185	ko01059,ko01130,map01059,map01130	M00827,M00828,M00832	R11368,R11393	RC00949,RC03431	ko00000,ko00001,ko00002	-	-	-	Flavin_Reduct
TLS2_k127_1701794_11	566461.SSFG_07712	4.493e-67	232.0	COG0824@1|root,COG0824@2|Bacteria,2IFNF@201174|Actinobacteria	201174|Actinobacteria	S	Thioesterase	tebC	-	-	ko:K15315	ko01059,map01059	-	R11436	RC00039,RC03437	ko00000,ko00001,ko01008	-	-	-	4HBT,4HBT_2
TLS2_k127_1701794_0	479432.Sros_6999	0.0	2071.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,2H477@201174|Actinobacteria,4EI5P@85012|Streptosporangiales	201174|Actinobacteria	IQ	Polyketide synthase dehydratase	-	-	-	ko:K13611,ko:K15314	ko01059,ko01130,map01059,map01130	M00824,M00825	R11435	-	ko00000,ko00001,ko00002,ko01004,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
TLS2_k127_1701794_5	882083.SacmaDRAFT_4561	1.146e-128	418.0	COG4658@1|root,COG4658@2|Bacteria,2GN3H@201174|Actinobacteria,4E1BV@85010|Pseudonocardiales	201174|Actinobacteria	C	electron transport chain	-	-	-	ko:K21163	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002	-	-	-	NQR2_RnfD_RnfE
TLS2_k127_1701794_2	369723.Strop_2699	9.904e-265	834.0	COG4658@1|root,COG4658@2|Bacteria,2GNVV@201174|Actinobacteria,4DBT4@85008|Micromonosporales	201174|Actinobacteria	C	PFAM ASPIC UnbV domain protein	-	-	-	ko:K21162	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002	-	-	-	FG-GAP,UnbV_ASPIC,VCBS
TLS2_k127_1701794_7	1449355.JQNR01000004_gene1621	5.667e-103	344.0	28IKZ@1|root,2Z8MJ@2|Bacteria,2HAVT@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1702)	-	-	-	ko:K21161	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002	-	-	-	DUF1702
TLS2_k127_1701794_6	479432.Sros_7003	2.193e-108	361.0	28IKZ@1|root,2ZB82@2|Bacteria,2I8F0@201174|Actinobacteria,4EGR9@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF1702)	-	-	-	ko:K21160	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002	-	-	-	DUF1702
TLS2_k127_1701794_4	471853.Bcav_3740	2.865e-156	499.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria	201174|Actinobacteria	E	decarboxylase	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS2_k127_1727742_9	134676.ACPL_1559	4.241e-21	93.0	2EHMB@1|root,33BD3@2|Bacteria,2HUYF@201174|Actinobacteria,4DGC3@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1727742_1	644283.Micau_4660	1.094e-132	433.0	COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria,4D95T@85008|Micromonosporales	201174|Actinobacteria	GL	Reverse transcriptase-like	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
TLS2_k127_1727742_3	644283.Micau_4661	1.949e-86	292.0	COG1579@1|root,COG1579@2|Bacteria,2GP84@201174|Actinobacteria,4DB7Y@85008|Micromonosporales	201174|Actinobacteria	S	C4-type zinc ribbon domain	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
TLS2_k127_1727742_2	391037.Sare_3597	3.853e-121	395.0	COG0327@1|root,COG0327@2|Bacteria,2GKHZ@201174|Actinobacteria,4D9MY@85008|Micromonosporales	201174|Actinobacteria	S	NIF3 (NGG1p interacting factor 3)	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
TLS2_k127_1727742_4	649831.L083_7614	6.733e-80	275.0	COG0637@1|root,COG0637@2|Bacteria,2I2XT@201174|Actinobacteria,4DAMV@85008|Micromonosporales	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
TLS2_k127_1727742_5	469371.Tbis_1993	8.304e-78	274.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,4DYE3@85010|Pseudonocardiales	201174|Actinobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TLS2_k127_1727742_6	33876.JNXY01000018_gene7810	1.349e-73	255.0	COG0452@1|root,COG0452@2|Bacteria,2GP82@201174|Actinobacteria,4DAKC@85008|Micromonosporales	201174|Actinobacteria	H	Flavoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Flavoprotein
TLS2_k127_1727742_0	1246995.AFR_08880	2.995e-165	533.0	COG1396@1|root,COG1396@2|Bacteria,2GN9P@201174|Actinobacteria,4D9DK@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
TLS2_k127_1727742_7	1120949.KB903332_gene9318	1.681e-67	235.0	2EJSR@1|root,33DHD@2|Bacteria,2GMHI@201174|Actinobacteria,4DBIR@85008|Micromonosporales	201174|Actinobacteria	S	Bifunctional DNA primase/polymerase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Prim-Pol
TLS2_k127_1819071_3	1121272.KB903249_gene1380	7.119e-75	270.0	COG1595@1|root,COG1595@2|Bacteria,2GRZW@201174|Actinobacteria	201174|Actinobacteria	K	RNA polymerase sigma-24 subunit, ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
TLS2_k127_1819071_5	402777.KB235904_gene4473	1.161e-60	227.0	COG1108@1|root,COG1108@2|Bacteria,1G46X@1117|Cyanobacteria,1HEVP@1150|Oscillatoriales	1117|Cyanobacteria	P	ABC 3 transport family	-	-	-	-	-	-	-	-	-	-	-	-	ABC-3
TLS2_k127_1819071_4	195250.CM001776_gene1892	2.627e-67	239.0	COG1121@1|root,COG1121@2|Bacteria,1G1KR@1117|Cyanobacteria,1GZ8M@1129|Synechococcus	1117|Cyanobacteria	P	Manganese zinc iron chelate ABC ransporter (MZT) family, ATP-binding protein	-	-	-	ko:K02074	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
TLS2_k127_1819071_1	1313172.YM304_20920	1.306e-94	322.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K09818	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
TLS2_k127_1819071_0	512565.AMIS_52280	2.568e-135	442.0	COG1741@1|root,COG1741@2|Bacteria,2GM9P@201174|Actinobacteria,4DABK@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
TLS2_k127_1819071_2	644283.Micau_4165	2.169e-75	264.0	COG0671@1|root,COG0671@2|Bacteria,2HIXE@201174|Actinobacteria,4DB5P@85008|Micromonosporales	201174|Actinobacteria	I	Phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS2_k127_1819071_6	1464048.JNZS01000011_gene4883	1.415e-16	88.0	COG0508@1|root,COG0508@2|Bacteria,2GQQK@201174|Actinobacteria,4DFUH@85008|Micromonosporales	201174|Actinobacteria	C	dehydrogenase complex catalyzes the overall conversion of	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1819071_7	649831.L083_1365	3.453e-05	46.0	2ADQJ@1|root,313FX@2|Bacteria,2H0DG@201174|Actinobacteria,4DDU9@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1819579_28	397278.JOJN01000012_gene2144	2.737e-08	67.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4DP00@85009|Propionibacteriales	201174|Actinobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Laminin_G_3,Malectin,PKD
TLS2_k127_1819579_8	1121946.AUAX01000036_gene1926	2.157e-154	509.0	COG1404@1|root,COG3055@1|root,COG1404@2|Bacteria,COG3055@2|Bacteria,2IF2T@201174|Actinobacteria,4DBYG@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Kelch_1,Peptidase_S8
TLS2_k127_1819579_11	35754.JNYJ01000050_gene7936	6.797e-141	462.0	COG1721@1|root,COG1721@2|Bacteria,2GK9A@201174|Actinobacteria,4D8VA@85008|Micromonosporales	201174|Actinobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF58
TLS2_k127_1819579_9	644283.Micau_1004	2.247e-153	490.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4DBN1@85008|Micromonosporales	201174|Actinobacteria	S	ATPase associated with various cellular activities	moxR2	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_1819579_24	134676.ACPL_4386	5.344e-59	221.0	29B69@1|root,2ZY4N@2|Bacteria,2GKQW@201174|Actinobacteria,4DCRE@85008|Micromonosporales	201174|Actinobacteria	-	-	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF4350
TLS2_k127_1819579_25	1121946.AUAX01000026_gene6283	9.332e-37	157.0	2CT9V@1|root,32SSX@2|Bacteria,2HS3F@201174|Actinobacteria,4DF67@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
TLS2_k127_1819579_26	644283.Micau_1007	8.964e-35	152.0	2F70E@1|root,33ZG5@2|Bacteria,2HUDM@201174|Actinobacteria,4DEJ4@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1819579_19	2002.JOEQ01000004_gene2722	3.279e-112	375.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria,4EHB9@85012|Streptosporangiales	201174|Actinobacteria	CP	ABC-2 family transporter protein	yhaP	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_1819579_18	469371.Tbis_1115	2.303e-112	376.0	COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria,4DX3X@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_1819579_12	263358.VAB18032_12500	5.761e-137	444.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4DCIX@85008|Micromonosporales	201174|Actinobacteria	P	TOBE domain	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
TLS2_k127_1819579_4	391037.Sare_1430	2.454e-198	639.0	COG1178@1|root,COG1178@2|Bacteria,2GKPT@201174|Actinobacteria,4D94Q@85008|Micromonosporales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
TLS2_k127_1819579_14	222534.KB893783_gene5303	2.926e-125	410.0	COG1840@1|root,COG1840@2|Bacteria,2HTI5@201174|Actinobacteria,4ESYN@85013|Frankiales	201174|Actinobacteria	P	extracellular solute-binding	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
TLS2_k127_1819579_17	356851.JOAN01000003_gene1530	2.263e-115	386.0	COG1119@1|root,COG1119@2|Bacteria,2GIXX@201174|Actinobacteria,4DAAF@85008|Micromonosporales	201174|Actinobacteria	P	ABC transporter	ylmA	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
TLS2_k127_1819579_6	644283.Micau_1236	6.197e-174	553.0	COG1940@1|root,COG1940@2|Bacteria,2GJ3W@201174|Actinobacteria,4DAV0@85008|Micromonosporales	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2,ROK
TLS2_k127_1819579_0	644283.Micau_5069	0.0	2245.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4D965@85008|Micromonosporales	201174|Actinobacteria	E	Dehydrogenase	gdh	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
TLS2_k127_1819579_7	1150864.MILUP08_45867	2.073e-169	554.0	COG0768@1|root,COG0768@2|Bacteria,2GJAM@201174|Actinobacteria,4DAYD@85008|Micromonosporales	201174|Actinobacteria	M	penicillin-binding protein	pbp2B	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	MecA_N,PBP_dimer,Transpeptidase
TLS2_k127_1819579_10	219305.MCAG_01709	7.48e-146	467.0	COG0010@1|root,COG0010@2|Bacteria,2H81I@201174|Actinobacteria,4D8G7@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the arginase family	argI	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS2_k127_1819579_16	391037.Sare_3988	4.362e-121	395.0	COG3118@1|root,COG3118@2|Bacteria,2GJ7B@201174|Actinobacteria,4D937@85008|Micromonosporales	201174|Actinobacteria	O	Thioredoxin	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
TLS2_k127_1819579_2	1120950.KB892757_gene6520	1.18e-281	879.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4DP9H@85009|Propionibacteriales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_1819579_1	1464048.JNZS01000011_gene4872	1e-323	997.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4DC8C@85008|Micromonosporales	201174|Actinobacteria	I	Methylmalonyl-CoA mutase	icmA	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS2_k127_1819579_15	644283.Micau_0572	5.907e-123	408.0	COG5438@1|root,COG5438@2|Bacteria,2GKJ4@201174|Actinobacteria,4D8GP@85008|Micromonosporales	201174|Actinobacteria	S	YibE F family protein	-	-	-	-	-	-	-	-	-	-	-	-	YibE_F
TLS2_k127_1819579_27	66869.JNXG01000024_gene2774	6.684e-11	71.0	COG1302@1|root,COG1302@2|Bacteria,2IMA3@201174|Actinobacteria,41AHA@629295|Streptomyces griseus group	201174|Actinobacteria	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
TLS2_k127_1819579_22	35754.JNYJ01000029_gene9438	2.224e-74	258.0	COG1136@1|root,COG1136@2|Bacteria,2IENJ@201174|Actinobacteria,4DBFF@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	ytrE	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1819579_20	35754.JNYJ01000029_gene9439	8.389e-111	364.0	COG1136@1|root,COG1136@2|Bacteria,2GIV7@201174|Actinobacteria,4DAZG@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_1819579_3	35754.JNYJ01000029_gene9440	2.032e-232	754.0	COG0577@1|root,COG0577@2|Bacteria,2HWDA@201174|Actinobacteria,4D9A8@85008|Micromonosporales	201174|Actinobacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
TLS2_k127_1819579_13	263358.VAB18032_29416	4.253e-131	430.0	COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria,4DAMM@85008|Micromonosporales	201174|Actinobacteria	E	Lao ao transport system	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS2_k127_1819579_5	369723.Strop_3610	2.31e-194	614.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4D9WC@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_1819579_23	644283.Micau_5100	2.106e-70	244.0	COG0346@1|root,COG0346@2|Bacteria,2IIPR@201174|Actinobacteria,4DCP3@85008|Micromonosporales	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
TLS2_k127_1819579_21	263358.VAB18032_29431	3.697e-79	271.0	COG3599@1|root,COG3599@2|Bacteria,2I2UK@201174|Actinobacteria,4D9JS@85008|Micromonosporales	201174|Actinobacteria	D	regulation of cell shape	-	-	-	-	-	-	-	-	-	-	-	-	DivIVA
TLS2_k127_190143_0	479435.Kfla_0728	3.52e-273	858.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria,4DU3U@85009|Propionibacteriales	201174|Actinobacteria	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
TLS2_k127_190143_2	710111.FraQA3DRAFT_4290	1.045e-158	505.0	COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria,4ERMY@85013|Frankiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_190143_3	1464048.JNZS01000025_gene745	5.959e-84	294.0	COG1670@1|root,COG3467@1|root,COG1670@2|Bacteria,COG3467@2|Bacteria,2GJ76@201174|Actinobacteria,4DASD@85008|Micromonosporales	201174|Actinobacteria	J	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Acetyltransf_3,Pyridox_ox_2
TLS2_k127_190143_4	644283.Micau_3331	1.224e-46	171.0	COG0824@1|root,COG0824@2|Bacteria,2II60@201174|Actinobacteria,4DE50@85008|Micromonosporales	201174|Actinobacteria	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
TLS2_k127_190143_1	1121946.AUAX01000036_gene1926	3.495e-166	539.0	COG1404@1|root,COG3055@1|root,COG1404@2|Bacteria,COG3055@2|Bacteria,2IF2T@201174|Actinobacteria,4DBYG@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Kelch_1,Peptidase_S8
TLS2_k127_1907433_34	330084.JNYZ01000019_gene4513	4.223e-35	140.0	2EHN0@1|root,33BDR@2|Bacteria,2IRZI@201174|Actinobacteria,4EBC7@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1907433_16	935839.JAGJ01000004_gene2031	6.801e-106	365.0	COG3103@1|root,COG3103@2|Bacteria,2IGZN@201174|Actinobacteria	201174|Actinobacteria	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1907433_5	263358.VAB18032_27291	5.217e-208	651.0	COG0379@1|root,COG0379@2|Bacteria,2GM59@201174|Actinobacteria,4D97S@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
TLS2_k127_1907433_1	263358.VAB18032_27296	4.03e-233	727.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4DBSS@85008|Micromonosporales	201174|Actinobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TLS2_k127_1907433_26	1246995.AFR_09340	5.515e-55	200.0	2AN86@1|root,31D67@2|Bacteria,2HWWU@201174|Actinobacteria,4DDUP@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3043)	-	GO:0008150,GO:0009605,GO:0009607,GO:0020012,GO:0030682,GO:0042783,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	-	-	-	-	-	-	-	-	-	DUF3043
TLS2_k127_1907433_36	644283.Micau_4582	2.702e-22	105.0	2DMQN@1|root,32T1U@2|Bacteria,2GS5T@201174|Actinobacteria,4DG6M@85008|Micromonosporales	201174|Actinobacteria	S	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
TLS2_k127_1907433_22	1246995.AFR_09330	1.267e-73	255.0	COG1296@1|root,COG1296@2|Bacteria,2GN6R@201174|Actinobacteria,4DCYF@85008|Micromonosporales	201174|Actinobacteria	E	AzlC protein	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
TLS2_k127_1907433_12	1246995.AFR_09320	3.233e-136	443.0	COG4586@1|root,COG4586@2|Bacteria,2GKSX@201174|Actinobacteria,4D8NW@85008|Micromonosporales	201174|Actinobacteria	S	ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1907433_18	644283.Micau_4586	2.954e-99	330.0	COG3694@1|root,COG3694@2|Bacteria,2GMBG@201174|Actinobacteria,4DC13@85008|Micromonosporales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
TLS2_k127_1907433_14	219305.MCAG_01302	2.316e-111	367.0	COG4587@1|root,COG4587@2|Bacteria,2GKX7@201174|Actinobacteria,4DAET@85008|Micromonosporales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
TLS2_k127_1907433_3	1121946.AUAX01000001_gene2130	4.558e-219	717.0	COG0457@1|root,COG0457@2|Bacteria,2ICUH@201174|Actinobacteria,4D9ZH@85008|Micromonosporales	201174|Actinobacteria	K	WG containing repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,WG_beta_rep
TLS2_k127_1907433_9	219305.MCAG_01305	7.265e-164	520.0	COG0667@1|root,COG0667@2|Bacteria,2GMT5@201174|Actinobacteria,4DAJ4@85008|Micromonosporales	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_1907433_35	263358.VAB18032_27351	7.732e-25	105.0	2EFWK@1|root,339NW@2|Bacteria,2IQXQ@201174|Actinobacteria,4DFWV@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1907433_15	1136417.AZWE01000002_gene3520	3.604e-111	377.0	COG2038@1|root,COG2087@1|root,COG2038@2|Bacteria,COG2087@2|Bacteria,2GM8Q@201174|Actinobacteria,4DAFQ@85008|Micromonosporales	201174|Actinobacteria	H	biosynthesis protein	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU,DBI_PRT
TLS2_k127_1907433_10	1464048.JNZS01000041_gene3526	7.232e-162	518.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4DA9S@85008|Micromonosporales	201174|Actinobacteria	E	Glycine cleavage system T protein	gcvT	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TLS2_k127_1907433_7	390989.JOEG01000014_gene3015	4.475e-183	586.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4D9FC@85008|Micromonosporales	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS2_k127_1907433_33	219305.MCAG_01313	3.283e-39	167.0	2E6TR@1|root,331DK@2|Bacteria,2IQF8@201174|Actinobacteria,4DEPE@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1907433_2	196162.Noca_2304	1.686e-223	701.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4DN01@85009|Propionibacteriales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_1907433_4	649831.L083_1863	1.103e-215	686.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4D8FV@85008|Micromonosporales	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_1907433_11	1150864.MILUP08_41753	2.959e-143	460.0	COG0122@1|root,COG0122@2|Bacteria,2GP69@201174|Actinobacteria,4D9BH@85008|Micromonosporales	201174|Actinobacteria	L	3-methyladenine DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1907433_21	512565.AMIS_67900	2.29e-78	273.0	COG1595@1|root,COG1595@2|Bacteria,2GM3E@201174|Actinobacteria,4DB9B@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_1907433_32	1246995.AFR_34885	8.63e-40	162.0	COG5662@1|root,COG5662@2|Bacteria,2GNCC@201174|Actinobacteria,4DEEJ@85008|Micromonosporales	201174|Actinobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_1907433_25	33876.JNXY01000033_gene2249	2.931e-64	234.0	2F0EE@1|root,33THG@2|Bacteria,2HEI8@201174|Actinobacteria,4DC56@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1907433_19	103733.JNYO01000047_gene7318	8.063e-80	293.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4DZ9G@85010|Pseudonocardiales	201174|Actinobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_15,Pyr_redox_2,Reductase_C
TLS2_k127_1907433_38	105422.BBPM01000001_gene4853	0.0001715	53.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,2NHD2@228398|Streptacidiphilus	201174|Actinobacteria	S	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_15,Pyr_redox_2,Reductase_C
TLS2_k127_1907433_27	1123024.AUII01000012_gene4233	2.925e-50	188.0	COG3652@1|root,COG3652@2|Bacteria,2I2VX@201174|Actinobacteria,4E4QU@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF4142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4142
TLS2_k127_1907433_8	263358.VAB18032_12830	3.006e-172	553.0	COG1793@1|root,COG1793@2|Bacteria,2I2EA@201174|Actinobacteria,4DA61@85008|Micromonosporales	201174|Actinobacteria	L	DNA ligase	ligC	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
TLS2_k127_1907433_6	644283.Micau_1645	1.534e-193	620.0	COG0596@1|root,COG0596@2|Bacteria,2GJYS@201174|Actinobacteria,4D9UE@85008|Micromonosporales	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_1907433_0	1121272.KB903272_gene523	1.534e-249	789.0	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,4DB3W@85008|Micromonosporales	201174|Actinobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
TLS2_k127_1907433_17	219305.MCAG_04474	6.158e-101	336.0	COG0569@1|root,COG0569@2|Bacteria,2GK4N@201174|Actinobacteria,4D8PS@85008|Micromonosporales	201174|Actinobacteria	P	TrkA-N domain	ceoB	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS2_k127_1907433_13	391037.Sare_1450	1.24e-112	368.0	COG0569@1|root,COG0569@2|Bacteria,2GKB9@201174|Actinobacteria,4DB9D@85008|Micromonosporales	201174|Actinobacteria	P	Putative NAD(P)-binding	ceoC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS2_k127_1907433_20	1150864.MILUP08_41696	4.602e-79	270.0	2AVV0@1|root,31MNQ@2|Bacteria,2GJKP@201174|Actinobacteria,4DDIS@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3159
TLS2_k127_1907433_31	263358.VAB18032_12610	2.846e-42	158.0	COG1200@1|root,COG1200@2|Bacteria,2IHRX@201174|Actinobacteria,4DDY4@85008|Micromonosporales	201174|Actinobacteria	KL	Nucleic acid binding, OB-fold, tRNA	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1907433_23	263358.VAB18032_12605	1.048e-72	254.0	28J4D@1|root,30NZ9@2|Bacteria,2I2E9@201174|Actinobacteria,4DMI3@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3710)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3710
TLS2_k127_1907433_24	644283.Micau_1598	6.783e-70	239.0	COG0756@1|root,COG0756@2|Bacteria,2IHYY@201174|Actinobacteria,4DDNH@85008|Micromonosporales	201174|Actinobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
TLS2_k127_1907433_30	219305.MCAG_04468	3.844e-43	166.0	2E4C2@1|root,32TEI@2|Bacteria,2I89W@201174|Actinobacteria,4DDCI@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3093)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3093
TLS2_k127_1907433_28	33876.JNXY01000033_gene2189	1.944e-45	166.0	2ATJW@1|root,32RNQ@2|Bacteria,2I810@201174|Actinobacteria,4DE2U@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4193)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4193
TLS2_k127_1907433_29	369723.Strop_1477	1.47e-44	169.0	2E1BJ@1|root,32WRF@2|Bacteria,2I7ZF@201174|Actinobacteria,4DEI7@85008|Micromonosporales	201174|Actinobacteria	S	LytR cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C
TLS2_k127_1907433_37	649831.L083_6697	1.039e-12	68.0	COG0483@1|root,COG0483@2|Bacteria,2GJQE@201174|Actinobacteria,4DACR@85008|Micromonosporales	201174|Actinobacteria	G	Inositol monophosphatase	suhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043167,GO:0043169,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS2_k127_1930539_9	35754.JNYJ01000022_gene8118	3.063e-116	389.0	COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria,4D92A@85008|Micromonosporales	201174|Actinobacteria	C	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_1930539_16	1179773.BN6_07780	6.459e-35	135.0	COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria,4E5G5@85010|Pseudonocardiales	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
TLS2_k127_1930539_2	1122138.AQUZ01000019_gene8148	7.911e-229	751.0	COG3227@1|root,COG3227@2|Bacteria,2GMQS@201174|Actinobacteria,4DN9H@85009|Propionibacteriales	2|Bacteria	E	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M36
TLS2_k127_1930539_3	351160.LRC303	5.892e-227	730.0	COG0525@1|root,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,2N93W@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1976	Anticodon_1,tRNA-synt_1
TLS2_k127_1930539_15	1206101.AZXC01000019_gene1432	1.421e-42	160.0	COG2120@1|root,COG2120@2|Bacteria,2IDT2@201174|Actinobacteria	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K22135	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_1930539_17	1283283.ATXA01000001_gene343	5.144e-24	104.0	COG2120@1|root,COG2120@2|Bacteria,2IJD0@201174|Actinobacteria	201174|Actinobacteria	S	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_1930539_19	267608.RSp1376	2.424e-14	83.0	COG1296@1|root,COG1296@2|Bacteria,1Q43G@1224|Proteobacteria,2VP0N@28216|Betaproteobacteria,1K5B9@119060|Burkholderiaceae	28216|Betaproteobacteria	E	AzlC protein	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
TLS2_k127_1930539_20	675635.Psed_3603	4.291e-05	52.0	2DMQN@1|root,32T1U@2|Bacteria,2GS5T@201174|Actinobacteria,4E6JM@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
TLS2_k127_1930539_0	298654.FraEuI1c_4593	3.885e-290	925.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2GM4U@201174|Actinobacteria	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD
TLS2_k127_1930539_8	1120949.KB903295_gene2237	6.435e-128	423.0	COG0654@1|root,COG0654@2|Bacteria,2I2TH@201174|Actinobacteria	201174|Actinobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS2_k127_1930539_6	1120949.KB903295_gene2236	5.086e-148	479.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4D9DG@85008|Micromonosporales	201174|Actinobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS2_k127_1930539_14	1283283.ATXA01000001_gene344	6.708e-70	245.0	COG1765@1|root,COG1765@2|Bacteria,2IG8A@201174|Actinobacteria	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_1930539_11	512565.AMIS_38370	1.734e-103	349.0	COG0372@1|root,COG0372@2|Bacteria,2GM3G@201174|Actinobacteria,4DCXN@85008|Micromonosporales	201174|Actinobacteria	CK	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt,HTH_17
TLS2_k127_1930539_4	66429.JOFL01000021_gene5623	1.325e-169	541.0	COG0372@1|root,COG0372@2|Bacteria,2GKST@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the citrate synthase family	citA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS2_k127_1930539_13	219305.MCAG_05449	8.031e-78	267.0	COG1277@1|root,COG1277@2|Bacteria,2GK3E@201174|Actinobacteria,4D9FS@85008|Micromonosporales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
TLS2_k127_1930539_5	356851.JOAN01000032_gene2809	1.253e-148	476.0	COG1131@1|root,COG1131@2|Bacteria,2GK1W@201174|Actinobacteria,4D8V1@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1930539_12	356851.JOAN01000032_gene2808	4.47e-82	290.0	COG1277@1|root,COG1277@2|Bacteria,2GKKP@201174|Actinobacteria,4D8U0@85008|Micromonosporales	201174|Actinobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS2_k127_1930539_7	356851.JOAN01000032_gene2807	7.357e-144	461.0	COG1131@1|root,COG1131@2|Bacteria,2GKWB@201174|Actinobacteria,4DAYJ@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1930539_1	926564.KI911667_gene6202	4.104e-267	838.0	COG2225@1|root,COG2225@2|Bacteria,2GJGP@201174|Actinobacteria,4F561@85017|Promicromonosporaceae	201174|Actinobacteria	C	Malate synthase	aceB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
TLS2_k127_1930539_10	675635.Psed_4788	3.557e-105	353.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4E05Y@85010|Pseudonocardiales	201174|Actinobacteria	C	Glycolate oxidase subunit GlcD	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_1936672_6	100226.SCO6193	3.057e-116	396.0	COG2197@1|root,COG2197@2|Bacteria,2IC7E@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_1936672_7	208439.AJAP_11375	1.795e-108	363.0	COG3591@1|root,COG3591@2|Bacteria,2GJVS@201174|Actinobacteria,4DX5J@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1936672_1	1121946.AUAX01000004_gene951	8.276e-252	782.0	COG1509@1|root,COG1509@2|Bacteria,2GM2P@201174|Actinobacteria,4D8ZB@85008|Micromonosporales	201174|Actinobacteria	E	Lysine 2,3-aminomutase	kamA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	-
TLS2_k127_1936672_4	1121946.AUAX01000004_gene950	6.303e-145	467.0	COG0604@1|root,COG0604@2|Bacteria,2I2UN@201174|Actinobacteria,4DMD7@85008|Micromonosporales	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	1.4.1.11	ko:K18012	ko00310,map00310	-	R03349	RC00888	ko00000,ko00001,ko01000	-	-	-	-
TLS2_k127_1936672_2	356851.JOAN01000014_gene2083	1.105e-210	668.0	COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria,4DA1Y@85008|Micromonosporales	201174|Actinobacteria	S	amidohydrolase	ytcJ	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_1936672_0	644283.Micau_3122	8.561e-270	838.0	COG0274@1|root,COG0274@2|Bacteria,2GUM7@201174|Actinobacteria,4DABU@85008|Micromonosporales	201174|Actinobacteria	F	D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit	-	-	5.4.3.3	ko:K01844	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	Lys-AminoMut_A
TLS2_k127_1936672_5	644283.Micau_3123	9.704e-117	381.0	COG2185@1|root,COG2185@2|Bacteria,2HF50@201174|Actinobacteria,4DA5D@85008|Micromonosporales	201174|Actinobacteria	I	Dimerisation domain of d-ornithine 4,5-aminomutase	kamE	-	5.4.3.3	ko:K18011	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,OAM_dimer
TLS2_k127_1936672_8	1150864.MILUP08_43500	2.499e-59	220.0	COG1607@1|root,COG1607@2|Bacteria,2IKM2@201174|Actinobacteria,4DDMP@85008|Micromonosporales	201174|Actinobacteria	I	Thioesterase superfamily	-	-	4.3.1.14	ko:K18014	ko00310,map00310	-	R03030	RC00833	ko00000,ko00001,ko01000	-	-	-	4HBT
TLS2_k127_1936672_3	345341.KUTG_05621	1.022e-169	544.0	COG3385@1|root,COG3385@2|Bacteria,2GKQB@201174|Actinobacteria,4E3EH@85010|Pseudonocardiales	201174|Actinobacteria	L	Insertion element 4 transposase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
TLS2_k127_1964368_2	351607.Acel_1047	1.199e-93	314.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4ESHW@85013|Frankiales	201174|Actinobacteria	C	PFAM Transketolase central region	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_1964368_1	463191.SSEG_09286	3.843e-154	504.0	COG1071@1|root,COG1071@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	-	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K11381,ko:K21416	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS2_k127_1964368_0	285535.JOEY01000011_gene6146	2.228e-249	779.0	COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
TLS2_k127_1964368_3	351607.Acel_1044	9.475e-74	253.0	COG3620@1|root,COG3837@1|root,COG3620@2|Bacteria,COG3837@2|Bacteria,2I4X7@201174|Actinobacteria	201174|Actinobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
TLS2_k127_1964368_4	1246995.AFR_12125	8.202e-31	121.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria	201174|Actinobacteria	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_1989552_7	1246474.ANBE01000012_gene3743	5.844e-53	194.0	2DBY6@1|root,2ZBTG@2|Bacteria,2IM2N@201174|Actinobacteria,4EP49@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1989552_6	649831.L083_4845	1.574e-55	198.0	COG3304@1|root,COG3304@2|Bacteria,2IKS5@201174|Actinobacteria,4DENT@85008|Micromonosporales	201174|Actinobacteria	S	Inner membrane component domain	yccF	-	-	-	-	-	-	-	-	-	-	-	YccF
TLS2_k127_1989552_4	1120948.KB903218_gene1991	1.19e-100	342.0	COG0500@1|root,COG0500@2|Bacteria,2I3GX@201174|Actinobacteria,4EE6R@85010|Pseudonocardiales	201174|Actinobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_1989552_3	1045009.AFXQ01000015_gene2506	5.078e-103	355.0	COG2197@1|root,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria,1WB2S@1268|Micrococcaceae	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_1989552_9	644283.Micau_5953	1.656e-11	70.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4DAYI@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_1989552_2	1121946.AUAX01000003_gene1803	2.115e-132	435.0	COG0477@1|root,COG2814@2|Bacteria,2GNZJ@201174|Actinobacteria,4DB6X@85008|Micromonosporales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_1989552_0	1136417.AZWE01000051_gene3902	0.0	1367.0	COG1020@1|root,COG1020@2|Bacteria,2GM1X@201174|Actinobacteria,4D9KM@85008|Micromonosporales	201174|Actinobacteria	Q	Lantibiotic dehydratase, C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Lant_dehydr_N,NAD_binding_4,PP-binding
TLS2_k127_1989552_1	1136417.AZWE01000034_gene503	1.964e-217	715.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria	201174|Actinobacteria	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
TLS2_k127_1989552_8	1223523.H340_13681	2.59e-34	141.0	2AVT6@1|root,31MKM@2|Bacteria,2INBR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1989552_5	58344.JOEL01000001_gene398	3.483e-86	293.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria	201174|Actinobacteria	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
TLS2_k127_2017610_18	391037.Sare_4750	6.694e-67	238.0	COG2027@1|root,COG2027@2|Bacteria,2GJPH@201174|Actinobacteria,4DATD@85008|Micromonosporales	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
TLS2_k127_2017610_17	1121946.AUAX01000003_gene1763	2.648e-90	299.0	COG0221@1|root,COG0221@2|Bacteria,2GM7F@201174|Actinobacteria,4D8WB@85008|Micromonosporales	201174|Actinobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3628	Pyrophosphatase
TLS2_k127_2017610_13	219305.MCAG_02441	1.598e-99	339.0	COG1404@1|root,COG1404@2|Bacteria,2GIRE@201174|Actinobacteria,4DAEM@85008|Micromonosporales	201174|Actinobacteria	O	Belongs to the peptidase S8 family	mycP	-	-	ko:K14743	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
TLS2_k127_2017610_3	1089545.KB913037_gene9006	7.013e-178	598.0	COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,2H1NS@201174|Actinobacteria,4EDPY@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,HTH_31,NB-ARC,TPR_10,TPR_12,TPR_7,Trans_reg_C
TLS2_k127_2017610_5	1121946.AUAX01000003_gene1769	3.554e-160	513.0	COG0265@1|root,COG0265@2|Bacteria,2GJ92@201174|Actinobacteria,4DA7U@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase s1 and s6 chymotrypsin hap	cvpA	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	Colicin_V,Trypsin_2
TLS2_k127_2017610_16	1464048.JNZS01000002_gene555	2.336e-90	303.0	COG0494@1|root,COG0494@2|Bacteria,2GKG9@201174|Actinobacteria,4D93T@85008|Micromonosporales	201174|Actinobacteria	L	Nudix hydrolase	nudL	-	-	ko:K18568	ko00332,ko01130,map00332,map01130	-	R10747	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TLS2_k127_2017610_22	219305.MCAG_02445	7.284e-42	164.0	COG0526@1|root,COG0526@2|Bacteria,2IMNX@201174|Actinobacteria,4DEZ0@85008|Micromonosporales	201174|Actinobacteria	CO	Thioredoxin	resA_1	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_2017610_12	1464048.JNZS01000002_gene557	1.13e-118	387.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4DB84@85008|Micromonosporales	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
TLS2_k127_2017610_9	369723.Strop_4320	1.19e-129	429.0	COG2843@1|root,COG2843@2|Bacteria,2HU4Z@201174|Actinobacteria,4DBAG@85008|Micromonosporales	201174|Actinobacteria	M	Bacterial capsule synthesis protein PGA_cap	capA	-	-	-	-	-	-	-	-	-	-	-	PGA_cap
TLS2_k127_2017610_10	369723.Strop_4322	1.485e-128	413.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,4DA89@85008|Micromonosporales	201174|Actinobacteria	K	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_2017610_15	33876.JNXY01000025_gene5445	3.467e-93	322.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4DBF8@85008|Micromonosporales	201174|Actinobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
TLS2_k127_2017610_2	33876.JNXY01000025_gene5444	5.77e-213	675.0	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4DB8C@85008|Micromonosporales	201174|Actinobacteria	I	carboxylase	-	-	6.4.1.3,6.4.1.4	ko:K01965,ko:K01968	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00036,M00373,M00741	R01859,R04138	RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
TLS2_k127_2017610_11	644283.Micau_5916	2.059e-119	392.0	COG0515@1|root,COG0515@2|Bacteria,2GIW5@201174|Actinobacteria,4DA8E@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,Septum_form
TLS2_k127_2017610_0	1150864.MILUP08_46772	0.0	1447.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,4D9YU@85008|Micromonosporales	201174|Actinobacteria	T	PFAM adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
TLS2_k127_2017610_14	1150864.MILUP08_46773	2.054e-98	330.0	COG0491@1|root,COG0491@2|Bacteria,2GKP9@201174|Actinobacteria,4D9MK@85008|Micromonosporales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	pksB_1	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_2017610_19	1246995.AFR_41640	1.203e-62	224.0	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria,4DDVD@85008|Micromonosporales	201174|Actinobacteria	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
TLS2_k127_2017610_23	644283.Micau_5921	8.528e-26	106.0	2E3JZ@1|root,32YI8@2|Bacteria,2GQIX@201174|Actinobacteria,4DFIW@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4177
TLS2_k127_2017610_24	356851.JOAN01000015_gene2460	5.926e-24	113.0	COG1716@1|root,COG1716@2|Bacteria,2IRBA@201174|Actinobacteria,4DEZX@85008|Micromonosporales	201174|Actinobacteria	T	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2017610_8	219305.MCAG_02468	1.981e-134	435.0	COG0003@1|root,COG0003@2|Bacteria,2GJ0J@201174|Actinobacteria,4DAB7@85008|Micromonosporales	201174|Actinobacteria	P	Anion-transporting ATPase	arsA_2	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
TLS2_k127_2017610_4	219305.MCAG_02469	1.156e-171	546.0	COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria,4D8U6@85008|Micromonosporales	201174|Actinobacteria	P	Anion-transporting ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
TLS2_k127_2017610_21	1121272.KB903261_gene6406	2.442e-51	182.0	2CC1Y@1|root,32TCV@2|Bacteria,2IQEP@201174|Actinobacteria,4DEMU@85008|Micromonosporales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	wblA	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS2_k127_2017610_1	263358.VAB18032_03045	1.927e-240	771.0	COG0744@1|root,COG2815@1|root,COG0744@2|Bacteria,COG2815@2|Bacteria,2GK21@201174|Actinobacteria,4D8QH@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyl transferase	pon1	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
TLS2_k127_2017610_20	543632.JOJL01000016_gene8899	1.09e-52	189.0	COG1610@1|root,COG1610@2|Bacteria,2IFFJ@201174|Actinobacteria,4DDQB@85008|Micromonosporales	201174|Actinobacteria	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS2_k127_2017610_7	35754.JNYJ01000038_gene5052	6.169e-138	446.0	COG1408@1|root,COG1408@2|Bacteria,2GJHT@201174|Actinobacteria,4D9XH@85008|Micromonosporales	201174|Actinobacteria	S	Metallophosphoesterase	ykuE	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
TLS2_k127_2017610_25	436229.JOEH01000009_gene4564	5.592e-14	73.0	COG1609@1|root,COG1609@2|Bacteria,2GSWK@201174|Actinobacteria,2NJKA@228398|Streptacidiphilus	201174|Actinobacteria	K	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Phage_int_SAM_3,Phage_integrase
TLS2_k127_2017610_6	1463857.JOFZ01000001_gene5776	7.876e-142	456.0	COG1609@1|root,COG1609@2|Bacteria,2GSWK@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Phage_int_SAM_3,Phage_integrase
TLS2_k127_2019876_23	1193181.BN10_900008	3.172e-06	49.0	COG4113@1|root,COG4113@2|Bacteria,2GR4U@201174|Actinobacteria,4FHBZ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_2019876_13	1120950.KB892744_gene2747	1.053e-44	166.0	COG2388@1|root,COG2388@2|Bacteria,2IMN6@201174|Actinobacteria	201174|Actinobacteria	S	GCN5-related N-acetyl-transferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
TLS2_k127_2019876_14	1246995.AFR_28915	3.947e-36	138.0	28HGI@1|root,2Z7SC@2|Bacteria,2GKHQ@201174|Actinobacteria,4DH5Q@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2019876_4	1137271.AZUM01000016_gene4385	6.138e-143	461.0	COG0655@1|root,COG0655@2|Bacteria,2GKTM@201174|Actinobacteria,4DY43@85010|Pseudonocardiales	201174|Actinobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS2_k127_2019876_22	1194972.MVAC_19361	1.267e-07	58.0	COG3509@1|root,COG3509@2|Bacteria,2GMTA@201174|Actinobacteria	201174|Actinobacteria	Q	Esterase, phb depolymerase family	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
TLS2_k127_2019876_15	1121019.AUMN01000002_gene254	1.961e-33	134.0	2CWCM@1|root,32SZF@2|Bacteria,2IQNB@201174|Actinobacteria,1WBUB@1268|Micrococcaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4260)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4260
TLS2_k127_2019876_17	477641.MODMU_3559	1.573e-26	113.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_2019876_0	477641.MODMU_1976	0.0	1148.0	COG1474@1|root,COG2909@1|root,COG1474@2|Bacteria,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_2019876_19	1120950.KB892744_gene2748	1.394e-22	99.0	COG2066@1|root,COG2066@2|Bacteria,2GKAV@201174|Actinobacteria,4DPKM@85009|Propionibacteriales	201174|Actinobacteria	E	Glutaminase	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase,STAS
TLS2_k127_2019876_18	1122182.KB903825_gene533	5.656e-25	113.0	COG0566@1|root,COG0566@2|Bacteria,2GP9S@201174|Actinobacteria,4DIFT@85008|Micromonosporales	201174|Actinobacteria	J	SpoU rRNA Methylase family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
TLS2_k127_2019876_11	219305.MCAG_04340	2.214e-53	199.0	COG0748@1|root,COG0748@2|Bacteria,2IFYD@201174|Actinobacteria,4DD92@85008|Micromonosporales	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS2_k127_2019876_8	543632.JOJL01000007_gene5545	1.615e-70	243.0	COG1695@1|root,COG1695@2|Bacteria,2GNA1@201174|Actinobacteria,4DBZU@85008|Micromonosporales	201174|Actinobacteria	K	Virulence activator alpha C-term	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
TLS2_k127_2019876_6	1120949.KB903295_gene2300	2.773e-105	349.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4DAEI@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_2019876_3	298654.FraEuI1c_3933	2.175e-154	520.0	COG4591@1|root,COG4591@2|Bacteria,2I445@201174|Actinobacteria	201174|Actinobacteria	M	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
TLS2_k127_2019876_1	219305.MCAG_05484	1.175e-196	622.0	COG1595@1|root,COG1595@2|Bacteria,2GMRK@201174|Actinobacteria,4DCY7@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
TLS2_k127_2019876_7	1150864.MILUP08_46169	4.423e-88	300.0	COG0491@1|root,COG0491@2|Bacteria,2GMSA@201174|Actinobacteria,4DCR6@85008|Micromonosporales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	ytnP_1	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_2019876_2	582899.Hden_1349	5.789e-191	616.0	2DMDG@1|root,32PV1@2|Bacteria,1MXEK@1224|Proteobacteria,2U2X5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Pectate_lyase_3
TLS2_k127_2019876_10	298655.KI912266_gene2996	2.898e-65	232.0	2DRM1@1|root,33C8J@2|Bacteria,2IJ2W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2019876_16	1449976.KALB_8088	5.755e-32	132.0	2B11J@1|root,31TEZ@2|Bacteria,2GSJI@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2019876_9	1150864.MILUP08_43252	1.26e-65	228.0	COG3877@1|root,COG3877@2|Bacteria,2IJTS@201174|Actinobacteria,4DDM4@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
TLS2_k127_2019876_20	1463856.JOHY01000002_gene1101	1.285e-13	77.0	2AQCP@1|root,31FIX@2|Bacteria,2GY0Z@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2019876_24	953739.SVEN_2107	0.0002034	52.0	2ASIG@1|root,31HYZ@2|Bacteria,2IHCT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2019876_25	994479.GL877878_gene3322	0.0007529	46.0	2EN0I@1|root,33FNR@2|Bacteria,2GWHK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2019876_12	446470.Snas_3894	1.483e-52	201.0	COG3409@1|root,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_2,PG_binding_1
TLS2_k127_2019876_21	68199.JNZO01000014_gene3759	3.089e-11	70.0	2A04B@1|root,30N6W@2|Bacteria,2ITF3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2054744_19	771875.Ferpe_1400	1.634e-31	127.0	COG0256@1|root,COG0256@2|Bacteria,2GD32@200918|Thermotogae	200918|Thermotogae	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
TLS2_k127_2054744_16	909613.UO65_4421	1.786e-53	191.0	COG1071@1|root,COG1071@2|Bacteria,2I3T8@201174|Actinobacteria,4E079@85010|Pseudonocardiales	201174|Actinobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS2_k127_2054744_6	219305.MCAG_00366	1.148e-131	428.0	28HKZ@1|root,2Z7VP@2|Bacteria,2IANB@201174|Actinobacteria,4DB6K@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3050)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3050
TLS2_k127_2054744_5	103733.JNYO01000022_gene7015	5.347e-149	476.0	COG5285@1|root,COG5285@2|Bacteria,2GP77@201174|Actinobacteria,4E9IC@85010|Pseudonocardiales	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS2_k127_2054744_7	1122182.KB903825_gene762	1.489e-123	407.0	COG3185@1|root,COG3185@2|Bacteria,2GKG8@201174|Actinobacteria,4D9DA@85008|Micromonosporales	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	1.13.11.46	ko:K16421	ko00261,ko01055,ko01130,map00261,map01055,map01130	-	R06632	RC01471	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4,Glyoxalase_5
TLS2_k127_2054744_4	1463934.JOCF01000016_gene3716	1.76e-160	520.0	COG0304@1|root,COG0304@2|Bacteria,2GIY4@201174|Actinobacteria	201174|Actinobacteria	IQ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS2_k127_2054744_22	219305.MCAG_00371	3.709e-17	85.0	COG0236@1|root,COG0236@2|Bacteria,2GSX0@201174|Actinobacteria,4DFXZ@85008|Micromonosporales	201174|Actinobacteria	IQ	Phosphopantetheine attachment site	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS2_k127_2054744_3	1122182.KB903825_gene770	3.817e-168	542.0	COG0318@1|root,COG0318@2|Bacteria,2I8PR@201174|Actinobacteria,4D9XQ@85008|Micromonosporales	201174|Actinobacteria	IQ	AMP-dependent synthetase and ligase	-	-	2.7.7.97	ko:K21284	-	-	R11554	RC00043	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_2054744_14	749414.SBI_06842	2.153e-76	264.0	COG3629@1|root,COG3629@2|Bacteria,2GP8N@201174|Actinobacteria	201174|Actinobacteria	K	sarp family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
TLS2_k127_2054744_0	644283.Micau_3705	2.482e-246	772.0	COG0318@1|root,COG0318@2|Bacteria,2GJI9@201174|Actinobacteria,4D9K2@85008|Micromonosporales	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_2054744_13	105425.BBPL01000015_gene2594	6.338e-90	304.0	COG0842@1|root,COG0842@2|Bacteria,2GJGH@201174|Actinobacteria,2NMS3@228398|Streptacidiphilus	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_2054744_10	35754.JNYJ01000008_gene3232	2.844e-114	385.0	COG1020@1|root,COG1020@2|Bacteria,2GSRJ@201174|Actinobacteria,4DI0J@85008|Micromonosporales	201174|Actinobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	Condensation
TLS2_k127_2054744_8	35754.JNYJ01000008_gene3232	4.514e-121	404.0	COG1020@1|root,COG1020@2|Bacteria,2GSRJ@201174|Actinobacteria,4DI0J@85008|Micromonosporales	201174|Actinobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	Condensation
TLS2_k127_2054744_9	479433.Caci_3263	9.982e-119	391.0	COG0332@1|root,COG0332@2|Bacteria,2IBGC@201174|Actinobacteria	201174|Actinobacteria	I	Pfam 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C,FAE1_CUT1_RppA
TLS2_k127_2054744_21	105425.BBPL01000013_gene1736	4.741e-22	98.0	COG0236@1|root,COG0236@2|Bacteria,2GRK8@201174|Actinobacteria,2NK3U@228398|Streptacidiphilus	201174|Actinobacteria	IQ	Phosphopantetheine attachment site	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS2_k127_2054744_17	909613.UO65_4424	1.821e-49	192.0	COG0332@1|root,COG0332@2|Bacteria,2IPEY@201174|Actinobacteria,4EE8I@85010|Pseudonocardiales	201174|Actinobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2054744_12	1463934.JOCF01000016_gene3724	2.714e-90	320.0	COG4627@1|root,COG4627@2|Bacteria,2GP9I@201174|Actinobacteria	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_2054744_1	675635.Psed_3245	9.669e-195	644.0	COG3899@1|root,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria,4E3EA@85010|Pseudonocardiales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Guanylate_cyc,Trans_reg_C
TLS2_k127_2054744_20	1217720.ALOX01000045_gene1303	8.546e-25	109.0	COG0500@1|root,COG0500@2|Bacteria,1N3PV@1224|Proteobacteria,2TVNH@28211|Alphaproteobacteria,2JQZB@204441|Rhodospirillales	204441|Rhodospirillales	Q	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_2054744_2	1132441.KI519455_gene2359	1.852e-169	544.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,1W7WM@1268|Micrococcaceae	201174|Actinobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS2_k127_2054744_15	749927.AMED_0665	1.26e-68	258.0	2DJUV@1|root,307EN@2|Bacteria,2HKCJ@201174|Actinobacteria,4E25D@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2054744_18	65497.JODV01000023_gene1698	8.3e-33	136.0	COG2815@1|root,COG2815@2|Bacteria,2ID52@201174|Actinobacteria,4E60I@85010|Pseudonocardiales	201174|Actinobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
TLS2_k127_2054744_11	405948.SACE_3375	2.795e-104	357.0	COG0457@1|root,COG1396@1|root,COG0457@2|Bacteria,COG1396@2|Bacteria,2GKEY@201174|Actinobacteria,4EDPQ@85010|Pseudonocardiales	201174|Actinobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
TLS2_k127_2054744_23	1120934.KB894420_gene2275	4.303e-09	67.0	2E7U3@1|root,33294@2|Bacteria,2INHP@201174|Actinobacteria,4E45H@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2074347_63	1869.MB27_30340	3.682e-40	153.0	COG4268@1|root,COG4268@2|Bacteria,2GKET@201174|Actinobacteria,4DI7A@85008|Micromonosporales	201174|Actinobacteria	L	McrBC 5-methylcytosine restriction system component	-	-	-	ko:K19147	-	-	-	-	ko00000,ko02048	-	-	-	McrBC
TLS2_k127_2074347_61	446466.Cfla_3473	4.609e-44	170.0	COG0454@1|root,COG0456@2|Bacteria,2GPVQ@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_2074347_51	1236902.ANAS01000038_gene3057	1.424e-60	219.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria,4EGC3@85012|Streptosporangiales	201174|Actinobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
TLS2_k127_2074347_22	1122138.AQUZ01000005_gene2599	3.871e-156	504.0	COG0477@1|root,COG2814@2|Bacteria,2GJU2@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS2_k127_2074347_20	1122138.AQUZ01000005_gene2598	9.051e-161	516.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_2074347_28	1122138.AQUZ01000011_gene4904	2.473e-128	419.0	2FG3N@1|root,34806@2|Bacteria,2I9A7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
TLS2_k127_2074347_73	298654.FraEuI1c_3610	4.854e-10	70.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS2_k127_2074347_11	1120950.KB892748_gene3199	1.811e-210	675.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GMMM@201174|Actinobacteria,4DPPX@85009|Propionibacteriales	201174|Actinobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_2074347_23	446470.Snas_1512	7.191e-149	484.0	COG0168@1|root,COG0168@2|Bacteria,2GKKS@201174|Actinobacteria,4EZ6C@85014|Glycomycetales	201174|Actinobacteria	P	Cation transport protein	ktrB	-	-	-	-	-	-	-	-	-	-	-	TrkH
TLS2_k127_2074347_9	644283.Micau_4188	6.141e-264	830.0	COG3408@1|root,COG3408@2|Bacteria,2IB24@201174|Actinobacteria,4D8TX@85008|Micromonosporales	201174|Actinobacteria	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
TLS2_k127_2074347_0	1150864.MILUP08_44820	0.0	1318.0	COG1452@1|root,COG1452@2|Bacteria,2GNM6@201174|Actinobacteria,4DMCF@85008|Micromonosporales	201174|Actinobacteria	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
TLS2_k127_2074347_3	219305.MCAG_04700	0.0	1026.0	COG0366@1|root,COG0366@2|Bacteria,2GJKR@201174|Actinobacteria,4D9JX@85008|Micromonosporales	201174|Actinobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
TLS2_k127_2074347_2	1869.MB27_27120	0.0	1084.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria,4DAHA@85008|Micromonosporales	201174|Actinobacteria	G	Maltogenic Amylase, C-terminal domain	treS	GO:0000023,GO:0000271,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016160,GO:0016161,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046872,GO:0047471,GO:0055114,GO:0071704,GO:0071944,GO:1901576	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	iNJ661.Rv0126	Alpha-amylase,Malt_amylase_C
TLS2_k127_2074347_14	35754.JNYJ01000034_gene2184	6.685e-180	578.0	COG3281@1|root,COG3281@2|Bacteria,2GKAP@201174|Actinobacteria,4D8WX@85008|Micromonosporales	201174|Actinobacteria	G	protein, probably involved in trehalose biosynthesis	mak	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576	2.7.1.175	ko:K16146	ko00500,ko01100,map00500,map01100	-	R09945	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
TLS2_k127_2074347_1	263358.VAB18032_13900	0.0	1177.0	COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,4DBXC@85008|Micromonosporales	201174|Actinobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TLS2_k127_2074347_42	994479.GL877878_gene2293	1.362e-73	259.0	COG1802@1|root,COG1802@2|Bacteria,2GKH7@201174|Actinobacteria,4E5XR@85010|Pseudonocardiales	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_2074347_38	1463861.JNXE01000041_gene7892	6.622e-86	305.0	COG0028@1|root,COG0028@2|Bacteria,2GKGX@201174|Actinobacteria	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_2074347_32	1464048.JNZS01000031_gene2928	5.467e-100	354.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4DB3I@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS2_k127_2074347_36	644283.Micau_5329	4.986e-94	336.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4D8DM@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	bldKD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_2074347_60	1449126.JQKL01000011_gene3617	7.686e-45	173.0	COG3836@1|root,COG3836@2|Bacteria,1UZZG@1239|Firmicutes,24DTX@186801|Clostridia,26B9T@186813|unclassified Clostridiales	186801|Clostridia	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_2074347_46	1117379.BABA_00155	1.488e-69	256.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli,1ZC1H@1386|Bacillus	91061|Bacilli	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components	oppC3	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_2074347_40	300852.55772719	1.63e-81	282.0	COG0601@1|root,COG0601@2|Bacteria,1WIGY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
TLS2_k127_2074347_62	1463909.KL585987_gene2626	7.202e-41	164.0	COG3608@1|root,COG3608@2|Bacteria,2IC8T@201174|Actinobacteria	201174|Actinobacteria	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
TLS2_k127_2074347_58	33898.JRHJ01000048_gene7749	2.668e-49	189.0	COG3608@1|root,COG3608@2|Bacteria,2IC8T@201174|Actinobacteria	201174|Actinobacteria	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
TLS2_k127_2074347_59	272943.RSP_3248	6.4e-49	196.0	COG0747@1|root,COG0747@2|Bacteria,1R410@1224|Proteobacteria,2TUWI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_2074347_31	675635.Psed_6736	6.542e-110	379.0	COG0154@1|root,COG0154@2|Bacteria,2GN7F@201174|Actinobacteria,4DZAM@85010|Pseudonocardiales	201174|Actinobacteria	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_2074347_33	1463887.KL590022_gene2749	9.24e-99	335.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
TLS2_k127_2074347_24	1068978.AMETH_0313	3.973e-138	449.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4DZF9@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_2074347_17	1150864.MILUP08_40520	1.161e-177	564.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4DB8N@85008|Micromonosporales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_2074347_35	391037.Sare_4062	5.896e-96	329.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4D9A2@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase s1 and s6 chymotrypsin hap	pepD	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_2074347_34	1123319.AUBE01000003_gene780	1.549e-97	329.0	COG1680@1|root,COG1680@2|Bacteria,2GNVX@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	bla	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_2074347_44	644283.Micau_5488	9.456e-71	245.0	COG0352@1|root,COG0352@2|Bacteria,2GKCN@201174|Actinobacteria,4DADP@85008|Micromonosporales	201174|Actinobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TLS2_k127_2074347_25	219305.MCAG_02050	6.635e-137	443.0	COG0665@1|root,COG0665@2|Bacteria,2GJVR@201174|Actinobacteria,4DAAE@85008|Micromonosporales	201174|Actinobacteria	E	Glycine oxidase	thiO	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
TLS2_k127_2074347_70	1306406.ASHX01000001_gene3172	9.003e-13	78.0	COG2104@1|root,COG2104@2|Bacteria,2GQKM@201174|Actinobacteria	201174|Actinobacteria	H	ThiS family	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS2_k127_2074347_29	263358.VAB18032_00950	1.247e-126	411.0	COG2022@1|root,COG2022@2|Bacteria,2GM62@201174|Actinobacteria,4D9I2@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	GO:0008150,GO:0040007	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
TLS2_k127_2074347_50	1150864.MILUP08_46275	5.868e-61	219.0	COG0352@1|root,COG0352@2|Bacteria,2IIB5@201174|Actinobacteria,4DDI0@85008|Micromonosporales	201174|Actinobacteria	H	Thiamine monophosphate synthase	thiE2	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TLS2_k127_2074347_37	219305.MCAG_02046	6.366e-86	302.0	COG0351@1|root,COG0351@2|Bacteria,2GKZM@201174|Actinobacteria,4DBUE@85008|Micromonosporales	201174|Actinobacteria	H	Phosphomethylpyrimidine kinase	thiD	GO:0008150,GO:0040007	2.7.1.35,2.7.1.49,2.7.4.7	ko:K00868,ko:K00941	ko00730,ko00750,ko01100,map00730,map00750,map01100	M00127	R00174,R01909,R02493,R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
TLS2_k127_2074347_5	263358.VAB18032_00935	1.516e-320	985.0	COG0422@1|root,COG0422@2|Bacteria,2GJ3Y@201174|Actinobacteria,4DA4Y@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016020,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0040007,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
TLS2_k127_2074347_67	1463821.JOGR01000002_gene458	5.196e-18	96.0	COG3325@1|root,COG3979@1|root,COG3325@2|Bacteria,COG3979@2|Bacteria,2GJGW@201174|Actinobacteria,4EYHP@85014|Glycomycetales	201174|Actinobacteria	G	Glyco_18	chiC2	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	Glyco_hydro_18,fn3
TLS2_k127_2074347_27	1394178.AWOO02000021_gene7306	1.051e-128	422.0	COG5297@1|root,COG5297@2|Bacteria,2I45I@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase family 6	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,Glyco_hydro_18,fn3
TLS2_k127_2074347_64	1150864.MILUP08_46272	3.122e-35	156.0	COG0477@1|root,COG0477@2|Bacteria,2IE90@201174|Actinobacteria,4DCMK@85008|Micromonosporales	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2074347_41	649831.L083_0980	8.007e-79	265.0	COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4DB9C@85008|Micromonosporales	201174|Actinobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
TLS2_k127_2074347_54	1122182.KB903813_gene2437	5.985e-59	213.0	COG0103@1|root,COG0103@2|Bacteria,2GNDY@201174|Actinobacteria,4DCXU@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
TLS2_k127_2074347_18	1122182.KB903813_gene2438	2.189e-176	563.0	COG1109@1|root,COG1109@2|Bacteria,2GN87@201174|Actinobacteria,4D99Z@85008|Micromonosporales	201174|Actinobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	GO:0008150,GO:0040007	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_2074347_4	33876.JNXY01000050_gene5544	1.176e-320	990.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,4DA3Y@85008|Micromonosporales	201174|Actinobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iNJ661.Rv3436c	GATase_6,SIS
TLS2_k127_2074347_49	1246995.AFR_04825	2.657e-61	213.0	COG0736@1|root,COG0736@2|Bacteria,2IQF6@201174|Actinobacteria,4DDCX@85008|Micromonosporales	201174|Actinobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_2074347_15	543632.JOJL01000008_gene5777	3.702e-179	573.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2GJHB@201174|Actinobacteria,4D9P8@85008|Micromonosporales	201174|Actinobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
TLS2_k127_2074347_19	219305.MCAG_02015	5.016e-168	537.0	COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4DAGJ@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TLS2_k127_2074347_30	33876.JNXY01000050_gene5538	1.353e-126	416.0	COG2267@1|root,COG2267@2|Bacteria,2GMCK@201174|Actinobacteria,4D9ZM@85008|Micromonosporales	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
TLS2_k127_2074347_56	1121946.AUAX01000003_gene1504	8.698e-57	203.0	COG0802@1|root,COG0802@2|Bacteria,2IKV2@201174|Actinobacteria,4DDER@85008|Micromonosporales	201174|Actinobacteria	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	tsaE	GO:0008150,GO:0040007	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
TLS2_k127_2074347_48	1121946.AUAX01000003_gene1500	4.776e-65	229.0	COG1214@1|root,COG1214@2|Bacteria,2GMTM@201174|Actinobacteria,4DD73@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase M22 glycoprotease	yeaZ	GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
TLS2_k127_2074347_55	644283.Micau_5442	3.429e-58	206.0	COG0454@1|root,COG0456@2|Bacteria,2IM9R@201174|Actinobacteria,4DDD7@85008|Micromonosporales	201174|Actinobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TLS2_k127_2074347_16	1150864.MILUP08_46231	2.783e-178	563.0	COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria,4D9ZK@85008|Micromonosporales	201174|Actinobacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
TLS2_k127_2074347_65	1136417.AZWE01000012_gene2519	2.932e-33	135.0	COG1359@1|root,COG1359@2|Bacteria,2GQYY@201174|Actinobacteria,4DEWU@85008|Micromonosporales	201174|Actinobacteria	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2074347_52	1121272.KB903250_gene2926	1.601e-59	210.0	COG2606@1|root,COG2606@2|Bacteria,2IHS8@201174|Actinobacteria,4DDH5@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
TLS2_k127_2074347_26	1150864.MILUP08_46222	6.879e-137	446.0	COG2265@1|root,COG2265@2|Bacteria,2GK97@201174|Actinobacteria,4DBK8@85008|Micromonosporales	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_15,Methyltransf_25
TLS2_k127_2074347_72	1121946.AUAX01000014_gene1230	2.794e-10	70.0	2BHJC@1|root,32BMT@2|Bacteria,2IQWW@201174|Actinobacteria,4DETD@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2074347_66	68170.KL590471_gene4201	1.85e-20	93.0	COG2905@1|root,COG2905@2|Bacteria,2GQMA@201174|Actinobacteria,4E6F8@85010|Pseudonocardiales	201174|Actinobacteria	T	Domain of unknown function (DUF1918)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1918
TLS2_k127_2074347_53	219305.MCAG_01994	3.842e-59	207.0	COG0234@1|root,COG0234@2|Bacteria,2IKTH@201174|Actinobacteria,4DE65@85008|Micromonosporales	201174|Actinobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TLS2_k127_2074347_7	644283.Micau_5429	4.364e-270	839.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4D9Q0@85008|Micromonosporales	201174|Actinobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL2	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009295,GO:0009408,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016465,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042026,GO:0042262,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043388,GO:0043590,GO:0044093,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0050896,GO:0051082,GO:0051098,GO:0051099,GO:0051101,GO:0051716,GO:0061077,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090143,GO:0090304,GO:0097159,GO:0101031,GO:1901360,GO:1901363,GO:1990220,GO:2000677,GO:2000679	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS2_k127_2074347_12	369723.Strop_3840	4.859e-203	645.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4D8HC@85008|Micromonosporales	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
TLS2_k127_2074347_57	219305.MCAG_01991	2.766e-50	183.0	2CC1Y@1|root,32S23@2|Bacteria,2IQS5@201174|Actinobacteria,4DDGR@85008|Micromonosporales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB3	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS2_k127_2074347_43	543632.JOJL01000008_gene5801	3.194e-71	251.0	COG2197@1|root,COG2197@2|Bacteria,2GN46@201174|Actinobacteria,4DAHR@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	bldM	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_2074347_47	356851.JOAN01000032_gene2758	2.225e-66	228.0	2DHRC@1|root,32U9K@2|Bacteria,2IJX8@201174|Actinobacteria,4DDEE@85008|Micromonosporales	201174|Actinobacteria	S	Family of unknown function (DUF5319)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5319
TLS2_k127_2074347_10	263358.VAB18032_00695	2.496e-245	766.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GITZ@201174|Actinobacteria,4D9JG@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TLS2_k127_2074347_13	35754.JNYJ01000004_gene5909	5.229e-198	622.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4DATG@85008|Micromonosporales	201174|Actinobacteria	F	IMP dehydrogenase	guaB3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
TLS2_k127_2074347_21	263358.VAB18032_00685	4.719e-159	515.0	COG0308@1|root,COG0308@2|Bacteria,2GJWF@201174|Actinobacteria,4D90U@85008|Micromonosporales	201174|Actinobacteria	E	Peptidase M1 membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
TLS2_k127_2074347_45	65497.JODV01000002_gene4223	2.213e-70	261.0	COG0500@1|root,COG2226@2|Bacteria,2GQ64@201174|Actinobacteria,4DYD6@85010|Pseudonocardiales	201174|Actinobacteria	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_2074347_8	1150864.MILUP08_46208	7.587e-267	843.0	COG2303@1|root,COG2303@2|Bacteria,2GJ3J@201174|Actinobacteria,4DABQ@85008|Micromonosporales	201174|Actinobacteria	E	GMC oxidoreductase	choA	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,GMC_oxred_C,GMC_oxred_N
TLS2_k127_2074347_69	926569.ANT_30980	2.775e-14	83.0	COG2998@1|root,COG2998@2|Bacteria,2G7MD@200795|Chloroflexi	200795|Chloroflexi	H	PBP superfamily domain	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
TLS2_k127_2074347_39	1150864.MILUP08_46517	2.426e-82	283.0	COG2981@1|root,COG2981@2|Bacteria,2GJZ4@201174|Actinobacteria,4D8FW@85008|Micromonosporales	201174|Actinobacteria	E	Etoposide-induced protein 2.4 (EI24)	-	-	-	ko:K06203	-	-	-	-	ko00000	-	-	-	EI24
TLS2_k127_2074347_6	219305.MCAG_01982	3.769e-273	846.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2GM09@201174|Actinobacteria,4DAVN@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
TLS2_k127_2096797_15	483219.LILAB_26365	1.67e-75	275.0	COG5184@1|root,COG5184@2|Bacteria,1R504@1224|Proteobacteria,42QHC@68525|delta/epsilon subdivisions,2WKUI@28221|Deltaproteobacteria,2YU2V@29|Myxococcales	28221|Deltaproteobacteria	DZ	Alpha-tubulin suppressor and related RCC1 domain-containing	-	-	-	-	-	-	-	-	-	-	-	-	RCC1
TLS2_k127_2096797_14	471852.Tcur_1769	4.155e-82	292.0	COG3540@1|root,COG3540@2|Bacteria,2GJCI@201174|Actinobacteria,4EFNV@85012|Streptosporangiales	201174|Actinobacteria	P	PhoD-like phosphatase, N-terminal domain	phoD	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
TLS2_k127_2096797_2	1172181.KB911714_gene4753	2.375e-199	656.0	COG2909@1|root,COG2909@2|Bacteria,2GM03@201174|Actinobacteria	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_2096797_20	710696.Intca_3445	2.78e-19	96.0	2AN8T@1|root,31D6V@2|Bacteria,2IHRU@201174|Actinobacteria,4FGIC@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4395)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4395
TLS2_k127_2096797_1	1172181.KB911714_gene4753	2.053e-218	707.0	COG2909@1|root,COG2909@2|Bacteria,2GM03@201174|Actinobacteria	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_2096797_3	1110697.NCAST_08_02010	2.243e-161	520.0	COG1231@1|root,COG1231@2|Bacteria,2GK23@201174|Actinobacteria,4FTWI@85025|Nocardiaceae	201174|Actinobacteria	E	Monoamine oxidase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS2_k127_2096797_16	1961.JOAK01000003_gene1753	1.896e-66	231.0	COG0454@1|root,COG0456@2|Bacteria,2II3I@201174|Actinobacteria	201174|Actinobacteria	K	Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
TLS2_k127_2096797_19	1078020.KEK_13538	2.261e-37	143.0	COG1917@1|root,COG1917@2|Bacteria,2IQI4@201174|Actinobacteria,2396F@1762|Mycobacteriaceae	201174|Actinobacteria	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2096797_17	1297742.A176_05102	1.063e-51	199.0	COG2850@1|root,COG2850@2|Bacteria	2|Bacteria	P	peptidyl-arginine hydroxylation	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_4
TLS2_k127_2096797_12	219305.MCAG_01145	4.48e-96	321.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,4DAYF@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
TLS2_k127_2096797_9	512565.AMIS_15770	2.519e-127	421.0	COG0559@1|root,COG0559@2|Bacteria,2GMAY@201174|Actinobacteria,4DBM5@85008|Micromonosporales	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997,ko:K11956	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	BPD_transp_2,CarboxypepD_reg
TLS2_k127_2096797_10	33876.JNXY01000009_gene8848	5.016e-114	378.0	COG4177@1|root,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria,4DA53@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_2096797_6	35754.JNYJ01000001_gene7329	6.703e-144	462.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4D8IV@85008|Micromonosporales	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_2096797_8	1121926.AXWO01000016_gene4099	8.452e-128	414.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4EYDX@85014|Glycomycetales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_2096797_4	298653.Franean1_1000	2.384e-146	473.0	COG0863@1|root,COG0863@2|Bacteria,2I9U5@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	-
TLS2_k127_2096797_11	1463821.JOGR01000007_gene87	4.966e-103	349.0	COG0683@1|root,COG0683@2|Bacteria,2GM00@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Extracellular ligand-binding receptor	livK	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_2096797_0	263358.VAB18032_26230	0.0	1294.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4D8IE@85008|Micromonosporales	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
TLS2_k127_2096797_13	593907.Celgi_2701	1.876e-90	308.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase type 11	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
TLS2_k127_2096797_18	101510.RHA1_ro03367	6.729e-43	160.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria,4G2E5@85025|Nocardiaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	arsR	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
TLS2_k127_2096797_7	219305.MCAG_01138	4.423e-128	421.0	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria,4DAD2@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_2096797_5	33876.JNXY01000009_gene8856	2.938e-144	460.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4DBRY@85008|Micromonosporales	201174|Actinobacteria	J	Ribosomal protein S1	rpsA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
TLS2_k127_2139912_6	1150864.MILUP08_43710	1.622e-141	451.0	COG1262@1|root,COG1262@2|Bacteria,2GK9Q@201174|Actinobacteria,4D9VE@85008|Micromonosporales	201174|Actinobacteria	C	Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine	egtB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0019439,GO:0019752,GO:0034641,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052708,GO:0052803,GO:0052805,GO:0055114,GO:0071704,GO:0097164,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	DinB_2,FGE-sulfatase
TLS2_k127_2139912_12	219305.MCAG_00316	3.749e-87	294.0	COG0121@1|root,COG0121@2|Bacteria,2GXCD@201174|Actinobacteria,4DB50@85008|Micromonosporales	201174|Actinobacteria	S	Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine	egtC	GO:0000096,GO:0000097,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006518,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006749,GO:0006751,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016020,GO:0016053,GO:0016054,GO:0019439,GO:0019752,GO:0032991,GO:0034641,GO:0042219,GO:0042398,GO:0043171,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0051186,GO:0051187,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052708,GO:0052803,GO:0052805,GO:0061672,GO:0071704,GO:0071944,GO:0097164,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902494,GO:1905368	3.5.1.118	ko:K07008	ko00340,map00340	-	R11021	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	GATase_6
TLS2_k127_2139912_8	649831.L083_7398	9.683e-137	442.0	COG4301@1|root,COG4301@2|Bacteria,2GJAX@201174|Actinobacteria,4DB6W@85008|Micromonosporales	201174|Actinobacteria	S	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine	egtD	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008213,GO:0008276,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016020,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0019439,GO:0019538,GO:0019752,GO:0032259,GO:0034641,GO:0036211,GO:0042398,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052707,GO:0052708,GO:0052709,GO:0052803,GO:0052805,GO:0071704,GO:0071944,GO:0097164,GO:0140096,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
TLS2_k127_2139912_2	446470.Snas_1334	2.887e-195	619.0	COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria,4EZNR@85014|Glycomycetales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_2139912_18	33876.JNXY01000039_gene6540	1.731e-31	130.0	COG5662@1|root,COG5662@2|Bacteria,2IM2X@201174|Actinobacteria,4DF0J@85008|Micromonosporales	201174|Actinobacteria	K	Putative zinc-finger	rsrA	GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_2139912_11	33876.JNXY01000039_gene6539	3.79e-101	337.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4D9I5@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigH	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2139912_16	219305.MCAG_01859	8.352e-47	173.0	2CC1Y@1|root,34BAK@2|Bacteria,2IM7Z@201174|Actinobacteria,4DEDR@85008|Micromonosporales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	-	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS2_k127_2139912_13	644283.Micau_5258	9.562e-83	284.0	COG2135@1|root,COG2135@2|Bacteria,2GKY8@201174|Actinobacteria,4DD0W@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the SOS response-associated peptidase family	yedK	-	-	-	-	-	-	-	-	-	-	-	SRAP
TLS2_k127_2139912_3	219305.MCAG_01861	5.137e-193	610.0	COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria,4DA5X@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TLS2_k127_2139912_5	1464048.JNZS01000024_gene878	1.256e-149	480.0	COG1162@1|root,COG1162@2|Bacteria,2GJ37@201174|Actinobacteria,4DAM5@85008|Micromonosporales	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
TLS2_k127_2139912_7	33876.JNXY01000039_gene6533	5.627e-140	448.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4D96T@85008|Micromonosporales	201174|Actinobacteria	G	Inositol monophosphatase	hisN	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS2_k127_2139912_19	512565.AMIS_73000	4.067e-31	123.0	COG4770@1|root,COG4770@2|Bacteria,2I2DF@201174|Actinobacteria,4DFRH@85008|Micromonosporales	201174|Actinobacteria	I	Biotin lipoyl attachment domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
TLS2_k127_2139912_14	219305.MCAG_01854	2.325e-52	193.0	COG0454@1|root,COG0456@2|Bacteria,2IQC7@201174|Actinobacteria,4DEF7@85008|Micromonosporales	201174|Actinobacteria	K	Gcn5-related n-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_2139912_4	644283.Micau_5247	9.854e-153	489.0	COG0449@1|root,COG0449@2|Bacteria,2GP4W@201174|Actinobacteria,4D9JE@85008|Micromonosporales	201174|Actinobacteria	M	Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
TLS2_k127_2139912_1	1121272.KB903291_gene3388	9.168e-231	722.0	COG3920@1|root,COG3920@2|Bacteria,2GKMP@201174|Actinobacteria,4D8K6@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	pdtaS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,H_kinase_N,HisKA_2,PAS_4
TLS2_k127_2139912_0	263358.VAB18032_30051	5.801e-285	882.0	COG0155@1|root,COG0155@2|Bacteria,2GJRN@201174|Actinobacteria,4DAJ2@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	sirA	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016002,GO:0016053,GO:0016491,GO:0016667,GO:0016673,GO:0019344,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.7.7.1,1.8.7.1	ko:K00366,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
TLS2_k127_2139912_10	644283.Micau_5242	1.097e-115	376.0	COG0175@1|root,COG0175@2|Bacteria,2GJ3Z@201174|Actinobacteria,4D9YN@85008|Micromonosporales	201174|Actinobacteria	EH	Belongs to the PAPS reductase family. CysH subfamily	cysH	GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TLS2_k127_2139912_15	356851.JOAN01000017_gene5923	5.951e-49	188.0	COG2138@1|root,COG2138@2|Bacteria,2GS51@201174|Actinobacteria,4DC6F@85008|Micromonosporales	201174|Actinobacteria	S	cobalamin (vitamin B12) biosynthesis CbiX protein	cbiX	-	-	-	-	-	-	-	-	-	-	-	CbiX
TLS2_k127_2139912_17	33876.JNXY01000039_gene6559	5.833e-43	158.0	2DMIE@1|root,32RSG@2|Bacteria,2IQCG@201174|Actinobacteria,4DEWF@85008|Micromonosporales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS2_k127_2139912_9	219305.MCAG_01844	7.951e-118	386.0	COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria,4D8WJ@85008|Micromonosporales	201174|Actinobacteria	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS2_k127_2184908_2	994479.GL877878_gene956	5.557e-63	229.0	COG1232@1|root,COG1562@1|root,COG1232@2|Bacteria,COG1562@2|Bacteria,2I2Z5@201174|Actinobacteria,4E1XZ@85010|Pseudonocardiales	201174|Actinobacteria	H	TIGRFAM squalene-associated FAD-dependent desaturase	hopC	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS2_k127_2184908_1	1120950.KB892742_gene2986	1.144e-85	292.0	COG1562@1|root,COG1562@2|Bacteria,2GNS9@201174|Actinobacteria,4DTCP@85009|Propionibacteriales	201174|Actinobacteria	I	Squalene/phytoene synthase	hopE	-	-	-	-	-	-	-	-	-	-	-	SQS_PSY
TLS2_k127_2184908_11	390989.JOEG01000001_gene4959	2.981e-07	59.0	29WE1@1|root,30HZR@2|Bacteria,2HUYC@201174|Actinobacteria,4DGC2@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2184908_0	928724.SacglDRAFT_01916	1.958e-87	298.0	COG5637@1|root,COG5637@2|Bacteria,2GMK7@201174|Actinobacteria,4DYKA@85010|Pseudonocardiales	201174|Actinobacteria	S	Cyclase dehydrase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TLS2_k127_2184908_5	105420.BBPO01000004_gene1436	5.82e-32	131.0	arCOG03092@1|root,32YMQ@2|Bacteria,2I3JS@201174|Actinobacteria	201174|Actinobacteria	S	Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure	gvpA	-	-	-	-	-	-	-	-	-	-	-	Gas_vesicle
TLS2_k127_2184908_7	1343740.M271_07240	9.741e-29	128.0	COG2214@1|root,COG2214@2|Bacteria,2I34A@201174|Actinobacteria	201174|Actinobacteria	O	Gas vesicle	-	-	-	-	-	-	-	-	-	-	-	-	GvpL_GvpF
TLS2_k127_2184908_9	1120948.KB903245_gene3553	6.58e-11	73.0	2EJC3@1|root,33D37@2|Bacteria,2GQN8@201174|Actinobacteria,4E7UP@85010|Pseudonocardiales	201174|Actinobacteria	S	Gas vesicle protein G	-	-	-	-	-	-	-	-	-	-	-	-	GvpG
TLS2_k127_2184908_8	67315.JOBD01000027_gene2564	3.218e-17	84.0	arCOG04040@1|root,334QT@2|Bacteria,2GQNG@201174|Actinobacteria	201174|Actinobacteria	S	Gas vesicle	-	-	-	-	-	-	-	-	-	-	-	-	GvpO
TLS2_k127_2184908_6	105420.BBPO01000004_gene1440	2.32e-29	122.0	2E5BC@1|root,3303G@2|Bacteria,2IR3J@201174|Actinobacteria,2NJZ0@228398|Streptacidiphilus	201174|Actinobacteria	S	Gas vesicle protein	gvpJ	-	-	-	-	-	-	-	-	-	-	-	Gas_vesicle
TLS2_k127_2184908_3	1206733.BAGC01000099_gene6183	8.36e-40	162.0	297MT@1|root,2ZUUR@2|Bacteria,2I3JT@201174|Actinobacteria,4FTY1@85025|Nocardiaceae	201174|Actinobacteria	S	Gas vesicle synthesis protein GvpL/GvpF	-	-	-	-	-	-	-	-	-	-	-	-	GvpL_GvpF
TLS2_k127_2184908_10	1068978.AMETH_3709	6.939e-11	71.0	2DRDP@1|root,33BB6@2|Bacteria,2GQXX@201174|Actinobacteria,4E7PV@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Gas vesicle protein	gvpS1	-	-	-	-	-	-	-	-	-	-	-	Gas_vesicle
TLS2_k127_2184908_4	35754.JNYJ01000047_gene3495	1.884e-34	138.0	arCOG06390@1|root,330IR@2|Bacteria,2HWX3@201174|Actinobacteria,4DKMH@85008|Micromonosporales	201174|Actinobacteria	S	Gas vesicle protein K	-	-	-	-	-	-	-	-	-	-	-	-	GvpK
TLS2_k127_2229725_2	58344.JOEL01000001_gene398	1.26e-291	911.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria	201174|Actinobacteria	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
TLS2_k127_2229725_1	58344.JOEL01000001_gene397	0.0	1874.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria	201174|Actinobacteria	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
TLS2_k127_2229725_0	1089545.KB913037_gene1078	0.0	2865.0	COG1020@1|root,COG1028@1|root,COG3319@1|root,COG3321@1|root,COG1020@2|Bacteria,COG1028@2|Bacteria,COG3319@2|Bacteria,COG3321@2|Bacteria,2GISR@201174|Actinobacteria,4DZ5P@85010|Pseudonocardiales	201174|Actinobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,Thioesterase,ketoacyl-synt
TLS2_k127_2229725_6	58344.JOEL01000001_gene395	8.966e-89	308.0	COG3208@1|root,COG3208@2|Bacteria,2IEPI@201174|Actinobacteria	201174|Actinobacteria	Q	Thioesterase involved in non-ribosomal peptide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Thioesterase
TLS2_k127_2229725_4	67373.JOBF01000012_gene3873	1.713e-147	477.0	COG0455@1|root,COG0455@2|Bacteria,2ICKZ@201174|Actinobacteria	201174|Actinobacteria	D	GSCFA family	-	-	-	-	-	-	-	-	-	-	-	-	GSCFA
TLS2_k127_2229725_7	1133850.SHJG_1135	2.147e-72	251.0	2APDE@1|root,31EFX@2|Bacteria,2IC80@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2229725_3	58344.JOEL01000001_gene392	8.799e-150	477.0	COG2175@1|root,COG2175@2|Bacteria,2GNUC@201174|Actinobacteria	201174|Actinobacteria	Q	taurine catabolism dioxygenase	-	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
TLS2_k127_2229725_11	1108045.GORHZ_247_00410	2.268e-32	139.0	COG0644@1|root,COG0644@2|Bacteria,2GJDF@201174|Actinobacteria	201174|Actinobacteria	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS2_k127_2229725_14	1121946.AUAX01000025_gene6387	7.475e-05	49.0	COG0406@1|root,COG0406@2|Bacteria,2GKY6@201174|Actinobacteria,4DEY8@85008|Micromonosporales	201174|Actinobacteria	G	phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
TLS2_k127_2229725_10	1157635.KB892004_gene4515	1.545e-49	199.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_2229725_8	1120950.KB892762_gene5510	3.146e-62	215.0	COG3795@1|root,COG3795@2|Bacteria,2IMMY@201174|Actinobacteria,4DR5Q@85009|Propionibacteriales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_2229725_9	1996.JOFO01000004_gene3559	2.359e-51	196.0	COG4635@1|root,COG4635@2|Bacteria,2IQCQ@201174|Actinobacteria,4EKDT@85012|Streptosporangiales	201174|Actinobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
TLS2_k127_2229725_5	543632.JOJL01000040_gene2160	8.684e-133	426.0	COG3173@1|root,COG3173@2|Bacteria,2I5KC@201174|Actinobacteria,4DMPJ@85008|Micromonosporales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_2229725_13	1120949.KB903299_gene5930	3.141e-10	66.0	COG1569@1|root,COG1569@2|Bacteria,2IMP1@201174|Actinobacteria	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
TLS2_k127_2229725_12	1120949.KB903299_gene5931	8.865e-24	102.0	COG3311@1|root,COG3311@2|Bacteria,2IQFY@201174|Actinobacteria,4DGB1@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
TLS2_k127_2246763_0	219305.MCAG_04532	2.254e-149	484.0	COG1653@1|root,COG1653@2|Bacteria,2GJIP@201174|Actinobacteria,4DAQW@85008|Micromonosporales	201174|Actinobacteria	G	extracellular solute-binding protein, family 1	-	-	-	ko:K10240	ko02010,map02010	M00206	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.23	-	-	SBP_bac_8
TLS2_k127_2246763_2	644283.Micau_1661	5.502e-85	290.0	COG4974@1|root,COG4974@2|Bacteria,2I9XB@201174|Actinobacteria,4DD29@85008|Micromonosporales	201174|Actinobacteria	L	PFAM plasmid pRiA4b ORF-3 family protein	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
TLS2_k127_2246763_3	1150864.MILUP08_41762	8.534e-65	232.0	COG1985@1|root,COG1985@2|Bacteria,2GN2P@201174|Actinobacteria,4DBG0@85008|Micromonosporales	201174|Actinobacteria	H	bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_2246763_1	356851.JOAN01000008_gene3000	2.488e-149	478.0	COG0433@1|root,COG0433@2|Bacteria,2I0H5@201174|Actinobacteria,4D9TP@85008|Micromonosporales	201174|Actinobacteria	S	COG0433 Predicted ATPase	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_2257310_0	263358.VAB18032_29631	5.838e-199	636.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,4D8G8@85008|Micromonosporales	201174|Actinobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
TLS2_k127_2257310_5	543632.JOJL01000081_gene3163	1.485e-43	164.0	COG3576@1|root,COG3576@2|Bacteria,2II3S@201174|Actinobacteria,4DF8Y@85008|Micromonosporales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_2257310_6	356851.JOAN01000021_gene2376	3.824e-18	98.0	2E3YX@1|root,32YVV@2|Bacteria,2GTR4@201174|Actinobacteria,4DE8B@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2257310_4	1209984.BN978_07248	1.684e-88	308.0	COG1414@1|root,COG1414@2|Bacteria,2GJUA@201174|Actinobacteria,23EXZ@1762|Mycobacteriaceae	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	iclR	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
TLS2_k127_2257310_1	882086.SacxiDRAFT_1809	1.178e-174	558.0	COG0247@1|root,COG0247@2|Bacteria,2GIVX@201174|Actinobacteria,4DYFJ@85010|Pseudonocardiales	201174|Actinobacteria	C	Fe-S oxidoreductase	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
TLS2_k127_2257310_3	1120950.KB892768_gene5281	6.591e-99	344.0	COG0277@1|root,COG0277@2|Bacteria,2H3K3@201174|Actinobacteria,4DREZ@85009|Propionibacteriales	201174|Actinobacteria	C	FAD binding domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_2257310_2	675635.Psed_4788	2.766e-140	450.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4E05Y@85010|Pseudonocardiales	201174|Actinobacteria	C	Glycolate oxidase subunit GlcD	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_2272364_1	1313172.YM304_00360	4.05e-322	1015.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	sbtB	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Inhibitor_I9,PA,Peptidase_S8
TLS2_k127_2272364_10	1464048.JNZS01000021_gene2776	1.067e-60	212.0	COG2153@1|root,COG2153@2|Bacteria,2IFAM@201174|Actinobacteria,4DDZH@85008|Micromonosporales	201174|Actinobacteria	S	Acetyltransferase (GNAT) domain	elaA	-	-	ko:K02348	-	-	-	-	ko00000	-	-	-	Acetyltransf_10
TLS2_k127_2272364_14	67267.JNXT01000018_gene7845	5.347e-20	96.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.81	ko:K18545,ko:K18547	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Pro_Al_protease,Trypsin,Trypsin_2
TLS2_k127_2272364_7	1121946.AUAX01000041_gene4868	6.604e-119	387.0	COG3253@1|root,COG3253@2|Bacteria,2GK24@201174|Actinobacteria,4D9PH@85008|Micromonosporales	201174|Actinobacteria	S	chlorite dismutase	cld	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
TLS2_k127_2272364_6	644283.Micau_1628	2.421e-148	482.0	COG1232@1|root,COG1232@2|Bacteria,2GMMA@201174|Actinobacteria,4DA47@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemG	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS2_k127_2272364_5	219305.MCAG_04499	1.428e-165	528.0	COG0407@1|root,COG0407@2|Bacteria,2GMY6@201174|Actinobacteria,4D8XC@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS2_k127_2272364_15	1121272.KB903258_gene5312	2.523e-09	68.0	2B60Z@1|root,31YX8@2|Bacteria,2H1DP@201174|Actinobacteria,4DGG7@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2272364_9	391037.Sare_1473	1.359e-71	249.0	2AIF4@1|root,318WM@2|Bacteria,2GK8R@201174|Actinobacteria,4DB95@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3000)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3000
TLS2_k127_2272364_8	644283.Micau_1624	5.006e-74	278.0	COG0265@1|root,COG5164@1|root,COG0265@2|Bacteria,COG5164@2|Bacteria,2IJ6Q@201174|Actinobacteria,4DDWI@85008|Micromonosporales	201174|Actinobacteria	O	peptidase S1 and S6, chymotrypsin Hap	hhoB	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Trypsin_2
TLS2_k127_2272364_4	35754.JNYJ01000005_gene5616	1.229e-192	607.0	COG0349@1|root,COG0349@2|Bacteria,2GKNM@201174|Actinobacteria,4DBRS@85008|Micromonosporales	201174|Actinobacteria	L	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
TLS2_k127_2272364_11	1150864.MILUP08_41141	5.235e-43	173.0	COG3468@1|root,COG3468@2|Bacteria,2IEKJ@201174|Actinobacteria,4DB5H@85008|Micromonosporales	201174|Actinobacteria	MU	outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2272364_3	219305.MCAG_04494	1.193e-219	685.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4DB96@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_2272364_0	391037.Sare_1468	0.0	1042.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,2GJ50@201174|Actinobacteria,4D957@85008|Micromonosporales	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadB	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
TLS2_k127_2272364_2	105425.BBPL01000016_gene2534	4.883e-301	951.0	COG4403@1|root,COG4403@2|Bacteria,2GKVV@201174|Actinobacteria,2NI0D@228398|Streptacidiphilus	201174|Actinobacteria	V	Domain of unknown function (DUF4135)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4135,LANC_like
TLS2_k127_2272364_13	1206737.BAGF01000042_gene2621	2.656e-20	101.0	2BKH9@1|root,32EY9@2|Bacteria,2H9QW@201174|Actinobacteria,4G73V@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2272364_12	219305.MCAG_03906	1.093e-32	129.0	2CD9P@1|root,345NP@2|Bacteria,2H7WE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2284456_13	391037.Sare_2315	1.699e-23	107.0	2EGVE@1|root,33AMN@2|Bacteria,2GRZT@201174|Actinobacteria,4DFVX@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2284456_2	1150864.MILUP08_43329	4.16e-167	530.0	COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,4DBBX@85008|Micromonosporales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_2284456_7	1121272.KB903257_gene5445	3.4e-115	376.0	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,4DBDT@85008|Micromonosporales	201174|Actinobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
TLS2_k127_2284456_9	1869.MB27_27680	5.038e-94	313.0	COG0406@1|root,COG0406@2|Bacteria,2GK8N@201174|Actinobacteria,4D8EC@85008|Micromonosporales	201174|Actinobacteria	G	phosphoglycerate mutase	-	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
TLS2_k127_2284456_10	1869.MB27_27675	3.312e-86	288.0	298YA@1|root,2ZW25@2|Bacteria,2GIYI@201174|Actinobacteria,4D9TX@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
TLS2_k127_2284456_8	263358.VAB18032_22950	4.18e-113	370.0	COG5032@1|root,COG5032@2|Bacteria,2GME7@201174|Actinobacteria,4D9NY@85008|Micromonosporales	201174|Actinobacteria	BDLTU	Phosphatidylinositol	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2284456_1	1150864.MILUP08_43337	1.587e-211	664.0	COG0215@1|root,COG0215@2|Bacteria,2GJZR@201174|Actinobacteria,4D9Y7@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins	mshC	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iNJ661.Rv2130c	tRNA-synt_1e
TLS2_k127_2284456_12	390989.JOEG01000005_gene1968	2.004e-48	183.0	2DDJY@1|root,32U1P@2|Bacteria,2H1DV@201174|Actinobacteria,4DGCZ@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3105
TLS2_k127_2284456_4	390989.JOEG01000005_gene1969	2.154e-136	446.0	COG1994@1|root,COG1994@2|Bacteria,2I9PV@201174|Actinobacteria,4DDWQ@85008|Micromonosporales	201174|Actinobacteria	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2284456_3	390989.JOEG01000005_gene1971	1.648e-136	448.0	COG0476@1|root,COG0476@2|Bacteria,2HGW4@201174|Actinobacteria,4DEP0@85008|Micromonosporales	201174|Actinobacteria	H	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
TLS2_k127_2284456_15	1394178.AWOO02000018_gene6652	7.994e-14	84.0	COG5635@1|root,COG5635@2|Bacteria,2GJIF@201174|Actinobacteria,4EJWK@85012|Streptosporangiales	201174|Actinobacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,Trypsin_2,WD40
TLS2_k127_2284456_14	402777.KB235898_gene5121	1.945e-23	114.0	COG0457@1|root,COG0457@2|Bacteria,1G4NE@1117|Cyanobacteria,1HAEC@1150|Oscillatoriales	1117|Cyanobacteria	S	Soluble NSF attachment protein, SNAP	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_7
TLS2_k127_2284456_5	219305.MCAG_05480	5.938e-135	433.0	COG2188@1|root,COG2188@2|Bacteria,2IAGW@201174|Actinobacteria,4D8VJ@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator, GntR family	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS2_k127_2284456_6	649831.L083_5097	1.297e-123	407.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4DMER@85008|Micromonosporales	201174|Actinobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
TLS2_k127_2284456_0	219305.MCAG_05482	0.0	1892.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4DB0D@85008|Micromonosporales	201174|Actinobacteria	E	Methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TLS2_k127_2284456_11	219305.MCAG_05489	1.755e-66	235.0	COG0637@1|root,COG0637@2|Bacteria,2GJNG@201174|Actinobacteria,4DCND@85008|Micromonosporales	201174|Actinobacteria	S	Hydrolase	hisE	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS2_k127_2302598_11	253839.SSNG_03612	3.776e-21	101.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2GMKG@201174|Actinobacteria	201174|Actinobacteria	P	Copper resistance protein CopC	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
TLS2_k127_2302598_15	1120959.ATXF01000010_gene115	2.223e-06	59.0	COG1669@1|root,COG1669@2|Bacteria,2GR6M@201174|Actinobacteria,4FPZI@85023|Microbacteriaceae	201174|Actinobacteria	K	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	HTH_3,HTH_31,NTP_transf_2
TLS2_k127_2302598_8	1121946.AUAX01000006_gene3309	1.16e-93	328.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4D8PV@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_2302598_14	356851.JOAN01000024_gene4461	4.035e-07	52.0	COG1132@1|root,COG1132@2|Bacteria,2GJ8B@201174|Actinobacteria,4D9A9@85008|Micromonosporales	201174|Actinobacteria	V	ABC-type multidrug transport system, ATPase and permease components	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
TLS2_k127_2302598_7	1211815.CBYP010000052_gene768	1.029e-108	358.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4ERPZ@85013|Frankiales	201174|Actinobacteria	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	cutM	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_2302598_0	1120949.KB903358_gene5049	0.0	1269.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4DCJ0@85008|Micromonosporales	201174|Actinobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_2302598_9	471852.Tcur_4234	3.033e-70	242.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria,4EINF@85012|Streptosporangiales	201174|Actinobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_2302598_6	390989.JOEG01000005_gene1864	4.211e-110	369.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4DCIW@85008|Micromonosporales	201174|Actinobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS2_k127_2302598_3	1120949.KB903358_gene5046	8.492e-122	398.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4DA23@85008|Micromonosporales	201174|Actinobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
TLS2_k127_2302598_2	469371.Tbis_0139	2.264e-146	478.0	COG1835@1|root,COG1835@2|Bacteria,2GN56@201174|Actinobacteria,4E1B0@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS2_k127_2302598_13	446470.Snas_1591	1.578e-07	61.0	2ATPF@1|root,31J82@2|Bacteria,2GXF7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2302598_5	390989.JOEG01000003_gene4490	1.575e-114	398.0	COG1721@1|root,COG1721@2|Bacteria,2I9E2@201174|Actinobacteria,4DA7C@85008|Micromonosporales	201174|Actinobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_2302598_1	479432.Sros_3911	7.242e-153	491.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4EFIG@85012|Streptosporangiales	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_2302598_12	1121946.AUAX01000003_gene1416	1.53e-13	79.0	2EG5A@1|root,339X8@2|Bacteria,2INII@201174|Actinobacteria,4DEBN@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2302598_4	1246995.AFR_20040	7.68e-121	395.0	COG0294@1|root,COG0294@2|Bacteria,2GJNI@201174|Actinobacteria,4D9P0@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TLS2_k127_2305137_4	477641.MODMU_2258	8.156e-138	451.0	COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4EUED@85013|Frankiales	201174|Actinobacteria	C	CoA-transferase family III	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
TLS2_k127_2305137_8	390989.JOEG01000001_gene4872	2.628e-114	377.0	COG0451@1|root,COG0451@2|Bacteria,2GP01@201174|Actinobacteria,4D9NN@85008|Micromonosporales	201174|Actinobacteria	GM	epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_2305137_11	219305.MCAG_02243	1.962e-82	276.0	2AZ39@1|root,31R9K@2|Bacteria,2GMCY@201174|Actinobacteria,4DA6C@85008|Micromonosporales	201174|Actinobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
TLS2_k127_2305137_2	644283.Micau_5680	6.679e-186	600.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4D8PR@85008|Micromonosporales	201174|Actinobacteria	M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway	mshA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_2305137_7	1150864.MILUP08_46505	1.467e-117	383.0	COG4221@1|root,COG4221@2|Bacteria,2GMGQ@201174|Actinobacteria,4DBJ4@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	sdh	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_2305137_5	219305.MCAG_02253	1.514e-128	426.0	COG0812@1|root,COG0812@2|Bacteria,2GIV2@201174|Actinobacteria,4D8ZQ@85008|Micromonosporales	201174|Actinobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
TLS2_k127_2305137_10	35754.JNYJ01000038_gene4933	4.346e-85	306.0	COG3154@1|root,COG3154@2|Bacteria,2I2XN@201174|Actinobacteria,4DCP8@85008|Micromonosporales	201174|Actinobacteria	I	MDMPI C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
TLS2_k127_2305137_1	644283.Micau_5186	8.626e-205	647.0	COG2273@1|root,COG2273@2|Bacteria,2I37S@201174|Actinobacteria,4D8T8@85008|Micromonosporales	201174|Actinobacteria	G	Carbohydrate binding family 6	lamA1	-	-	-	-	-	-	-	-	-	-	-	CBM_6,Glyco_hydro_16
TLS2_k127_2305137_0	1121926.AXWO01000008_gene2854	3.019e-207	651.0	COG1653@1|root,COG1653@2|Bacteria,2GJIP@201174|Actinobacteria	201174|Actinobacteria	G	Extracellular solute-binding protein	-	-	-	ko:K10240	ko02010,map02010	M00206	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.23	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_2305137_3	1121926.AXWO01000008_gene2855	3.362e-158	504.0	COG1175@1|root,COG1175@2|Bacteria,2GMV4@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	cebF	-	-	ko:K10241	ko02010,map02010	M00206	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.23	-	-	BPD_transp_1
TLS2_k127_2305137_6	1121926.AXWO01000008_gene2856	5.19e-120	403.0	COG0395@1|root,COG0395@2|Bacteria,2GK1V@201174|Actinobacteria	201174|Actinobacteria	G	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026,ko:K10242	ko02010,map02010	M00206,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.23	-	-	BPD_transp_1
TLS2_k127_2305137_9	479432.Sros_7167	1.667e-96	323.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria,4EHCC@85012|Streptosporangiales	201174|Actinobacteria	G	Glycosyl hydrolase family 1	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
TLS2_k127_2351654_45	345341.KUTG_03152	8.99e-60	218.0	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria,4EE2K@85010|Pseudonocardiales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_2351654_40	1150864.MILUP08_40923	4.541e-75	258.0	COG4122@1|root,COG4122@2|Bacteria,2GP7A@201174|Actinobacteria,4DAVE@85008|Micromonosporales	201174|Actinobacteria	S	O-Methyltransferase	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
TLS2_k127_2351654_18	326424.FRAAL4634	1.688e-121	406.0	COG0644@1|root,COG0644@2|Bacteria,2GJDF@201174|Actinobacteria	201174|Actinobacteria	C	Tryptophan halogenase	-	-	-	ko:K21256	ko01059,ko01130,map01059,map01130	M00833,M00834	R11414	RC01363	ko00000,ko00001,ko00002	-	-	-	Trp_halogenase
TLS2_k127_2351654_9	1150864.MILUP08_44156	2.195e-156	499.0	COG0500@1|root,COG0500@2|Bacteria,2I2Y4@201174|Actinobacteria,4D8D5@85008|Micromonosporales	201174|Actinobacteria	Q	Dimerisation domain	-	-	2.1.1.302	ko:K21377	-	-	-	-	ko00000,ko01000	-	-	-	Dimerisation2,Methyltransf_2
TLS2_k127_2351654_39	188626.HMPREF0321_0313	1.162e-79	276.0	COG3440@1|root,COG3440@2|Bacteria	2|Bacteria	V	regulation of methylation-dependent chromatin silencing	-	-	-	ko:K07454	-	-	-	-	ko00000	-	-	-	HNH_2
TLS2_k127_2351654_15	391037.Sare_4271	1.603e-131	426.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4D9KK@85008|Micromonosporales	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_2351654_21	644283.Micau_5478	1.617e-113	372.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4DC1V@85008|Micromonosporales	201174|Actinobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TLS2_k127_2351654_32	66874.JOFS01000005_gene3921	4.498e-91	312.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TLS2_k127_2351654_41	1246995.AFR_04750	6.084e-73	257.0	COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria,4DC4A@85008|Micromonosporales	201174|Actinobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TLS2_k127_2351654_35	263358.VAB18032_00900	1.196e-88	307.0	COG0683@1|root,COG0683@2|Bacteria,2GNVF@201174|Actinobacteria,4D9DR@85008|Micromonosporales	201174|Actinobacteria	E	Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_2351654_4	644283.Micau_5474	8.724e-234	756.0	COG0642@1|root,COG2205@2|Bacteria,2I2WT@201174|Actinobacteria,4D90B@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,NIT
TLS2_k127_2351654_46	644283.Micau_0789	6.562e-54	192.0	COG2018@1|root,COG2018@2|Bacteria,2IFB7@201174|Actinobacteria,4DD3M@85008|Micromonosporales	201174|Actinobacteria	S	Roadblock lc7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
TLS2_k127_2351654_47	219305.MCAG_02034	4.656e-43	160.0	COG1846@1|root,COG1846@2|Bacteria,2IKKA@201174|Actinobacteria,4DEQI@85008|Micromonosporales	201174|Actinobacteria	K	Protein of unknown function (DUF742)	-	-	-	-	-	-	-	-	-	-	-	-	DUF742
TLS2_k127_2351654_38	1246995.AFR_04775	5.314e-81	274.0	COG2229@1|root,COG2229@2|Bacteria,2GJIT@201174|Actinobacteria,4DBGC@85008|Micromonosporales	201174|Actinobacteria	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
TLS2_k127_2351654_43	1464048.JNZS01000001_gene184	2.492e-70	240.0	COG1522@1|root,COG1522@2|Bacteria,2GK3G@201174|Actinobacteria,4DCQ2@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix ASNC type	lrp_3	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS2_k127_2351654_7	1121272.KB903257_gene5492	6.948e-177	567.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4DA8V@85008|Micromonosporales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_2351654_13	644283.Micau_2970	7.288e-134	433.0	COG0258@1|root,COG0258@2|Bacteria,2GKTZ@201174|Actinobacteria,4DAFF@85008|Micromonosporales	201174|Actinobacteria	L	5'-3' exonuclease	polA_1	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
TLS2_k127_2351654_36	1150864.MILUP08_43433	6.105e-86	293.0	COG3300@1|root,COG3300@2|Bacteria,2GMG6@201174|Actinobacteria,4DB01@85008|Micromonosporales	201174|Actinobacteria	T	Bacterial signalling protein N terminal repeat	-	-	-	-	-	-	-	-	-	-	-	-	MHYT
TLS2_k127_2351654_0	263358.VAB18032_22695	0.0	1341.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,4D8G1@85008|Micromonosporales	201174|Actinobacteria	L	helicase	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
TLS2_k127_2351654_49	405948.SACE_0150	5.604e-36	142.0	COG0071@1|root,COG0071@2|Bacteria,2HUE8@201174|Actinobacteria,4E6ZS@85010|Pseudonocardiales	201174|Actinobacteria	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS2_k127_2351654_20	1150864.MILUP08_43426	4.026e-119	390.0	COG1597@1|root,COG1597@2|Bacteria,2GK3P@201174|Actinobacteria,4D9SI@85008|Micromonosporales	201174|Actinobacteria	I	Diacylglycerol kinase	dagK	GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
TLS2_k127_2351654_23	219305.MCAG_05510	2.037e-111	370.0	COG0805@1|root,COG0805@2|Bacteria,2GJK8@201174|Actinobacteria,4D8J1@85008|Micromonosporales	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
TLS2_k127_2351654_52	356851.JOAN01000023_gene4814	1.261e-22	102.0	COG1826@1|root,COG1826@2|Bacteria,2GQQX@201174|Actinobacteria,4DESG@85008|Micromonosporales	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	GO:0008150,GO:0040007	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS2_k127_2351654_17	644283.Micau_2958	3.396e-124	412.0	COG2378@1|root,COG2378@2|Bacteria,2GMAU@201174|Actinobacteria,4D9CZ@85008|Micromonosporales	201174|Actinobacteria	K	WYL domain	pafC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
TLS2_k127_2351654_10	1150864.MILUP08_43421	1.231e-146	491.0	COG2378@1|root,COG2378@2|Bacteria,2GM46@201174|Actinobacteria,4D9EX@85008|Micromonosporales	201174|Actinobacteria	K	WYL domain	pafB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K13572,ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
TLS2_k127_2351654_8	369723.Strop_2248	2.995e-157	503.0	COG3502@1|root,COG3502@2|Bacteria,2H2JJ@201174|Actinobacteria,4D8R3@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3866)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3866
TLS2_k127_2351654_22	35754.JNYJ01000008_gene3232	2.662e-112	380.0	COG1020@1|root,COG1020@2|Bacteria,2GSRJ@201174|Actinobacteria,4DI0J@85008|Micromonosporales	201174|Actinobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	Condensation
TLS2_k127_2351654_3	219305.MCAG_05505	1.147e-280	865.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4DA66@85008|Micromonosporales	201174|Actinobacteria	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
TLS2_k127_2351654_29	1464048.JNZS01000010_gene5320	5.028e-98	328.0	COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,4D8TY@85008|Micromonosporales	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
TLS2_k127_2351654_16	219305.MCAG_05503	1.129e-124	405.0	COG0638@1|root,COG0638@2|Bacteria,2GJ60@201174|Actinobacteria,4D8K2@85008|Micromonosporales	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
TLS2_k127_2351654_51	1121272.KB903257_gene5474	9.151e-23	99.0	2E9C2@1|root,333JS@2|Bacteria,2IQ5V@201174|Actinobacteria,4DFMG@85008|Micromonosporales	201174|Actinobacteria	S	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation	pup	GO:0003674,GO:0005488,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0031386,GO:0032446,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044877,GO:0051603,GO:0070490,GO:0070628,GO:0070647,GO:0071704,GO:1901564,GO:1901565,GO:1901575	-	ko:K13570	-	-	-	-	ko00000,ko04121	-	-	-	Pup
TLS2_k127_2351654_2	1464048.JNZS01000010_gene5317	1.121e-297	918.0	COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,4D9VI@85008|Micromonosporales	201174|Actinobacteria	S	Pup-ligase protein	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
TLS2_k127_2351654_1	1121946.AUAX01000031_gene1007	0.0	1035.0	COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4D9FY@85008|Micromonosporales	201174|Actinobacteria	O	AAA ATPase forming ring-shaped complexes	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
TLS2_k127_2351654_50	1120949.KB903358_gene5236	2.06e-31	124.0	COG1141@1|root,COG1141@2|Bacteria,2IKKX@201174|Actinobacteria,4DEYU@85008|Micromonosporales	201174|Actinobacteria	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_15
TLS2_k127_2351654_37	1136417.AZWE01000006_gene4315	3.896e-82	276.0	2DMK4@1|root,32S40@2|Bacteria,2IDPT@201174|Actinobacteria,4D90G@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4262
TLS2_k127_2351654_14	649831.L083_5076	2.381e-132	430.0	COG2519@1|root,COG2519@2|Bacteria,2GJPD@201174|Actinobacteria,4D96R@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	trmI	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
TLS2_k127_2351654_28	219305.MCAG_05495	3.391e-102	350.0	COG1994@1|root,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,4DADT@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
TLS2_k127_2351654_27	1283283.ATXA01000001_gene844	1.182e-102	343.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,4ERNB@85013|Frankiales	201174|Actinobacteria	L	PD-(D/E)XK nuclease superfamily	recB	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
TLS2_k127_2351654_31	1464048.JNZS01000010_gene5304	1.279e-91	306.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4DAIA@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_2351654_48	1121272.KB903249_gene2138	2.074e-40	162.0	COG3315@1|root,COG3315@2|Bacteria,2GNGD@201174|Actinobacteria	201174|Actinobacteria	Q	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM
TLS2_k127_2351654_30	1121272.KB903249_gene2139	8.657e-96	319.0	COG0842@1|root,COG0842@2|Bacteria,2HGK0@201174|Actinobacteria,4DC64@85008|Micromonosporales	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
TLS2_k127_2351654_34	1121272.KB903249_gene2140	3.946e-89	303.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4D98A@85008|Micromonosporales	201174|Actinobacteria	V	COG1131 ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_2351654_54	292459.STH2474	3.665e-06	57.0	COG1266@1|root,COG1266@2|Bacteria,1VHVC@1239|Firmicutes	1239|Firmicutes	V	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS2_k127_2351654_5	1121272.KB903249_gene2143	2.289e-212	667.0	COG1944@1|root,COG1944@2|Bacteria	2|Bacteria	S	ATP diphosphatase activity	sagD	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
TLS2_k127_2351654_11	1121272.KB903249_gene2144	4.82e-142	459.0	COG0476@1|root,COG0476@2|Bacteria,2IGKG@201174|Actinobacteria	201174|Actinobacteria	H	Involved in molybdopterin and thiamine biosynthesis, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2351654_12	1121272.KB903249_gene2145	2.414e-137	445.0	COG0778@1|root,COG0778@2|Bacteria,2I97S@201174|Actinobacteria,4DDP6@85008|Micromonosporales	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_2351654_42	446470.Snas_5068	6.424e-72	255.0	COG2197@1|root,COG2197@2|Bacteria,2GN80@201174|Actinobacteria,4EZRG@85014|Glycomycetales	201174|Actinobacteria	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_2351654_26	1352941.M877_19625	1.637e-105	356.0	COG4585@1|root,COG4585@2|Bacteria,2GNBG@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS2_k127_2351654_24	1122611.KB903954_gene5685	4.987e-111	382.0	COG1131@1|root,COG1131@2|Bacteria,2IBJD@201174|Actinobacteria,4EG9B@85012|Streptosporangiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_2351654_33	446468.Ndas_4702	6.769e-90	310.0	COG0842@1|root,COG0842@2|Bacteria,2IART@201174|Actinobacteria,4EI9B@85012|Streptosporangiales	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
TLS2_k127_2351654_25	1205910.B005_1471	4.113e-108	364.0	COG0842@1|root,COG0842@2|Bacteria,2I0XU@201174|Actinobacteria,4EGKP@85012|Streptosporangiales	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_2351654_19	1464048.JNZS01000010_gene5303	3.6e-119	391.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4D8X9@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter, ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_2351654_6	219305.MCAG_05490	6.19e-205	654.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria,4D8TF@85008|Micromonosporales	201174|Actinobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_2388257_9	356851.JOAN01000027_gene1248	4.943e-84	290.0	2DG92@1|root,2ZUZX@2|Bacteria,2IBNB@201174|Actinobacteria,4DK4D@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2388257_14	1549858.MC45_13760	5.674e-15	78.0	COG1724@1|root,COG1724@2|Bacteria,1NB5I@1224|Proteobacteria	1224|Proteobacteria	N	PFAM YcfA-like	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
TLS2_k127_2388257_15	195522.BD01_2030	2.488e-11	66.0	COG1598@1|root,arCOG02411@2157|Archaea,2Y1KD@28890|Euryarchaeota,244P3@183968|Thermococci	183968|Thermococci	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
TLS2_k127_2388257_7	68223.JNZY01000033_gene6748	2.914e-132	428.0	COG1595@1|root,COG1595@2|Bacteria,2GKBH@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2388257_6	1206729.BAFZ01000100_gene6000	1.154e-143	466.0	COG1252@1|root,COG1252@2|Bacteria,2GKC0@201174|Actinobacteria,4FU6C@85025|Nocardiaceae	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_2388257_11	1206735.BAGG01000066_gene2859	1.25e-73	252.0	COG4430@1|root,COG4430@2|Bacteria,2II0D@201174|Actinobacteria,4G14U@85025|Nocardiaceae	201174|Actinobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
TLS2_k127_2388257_13	1172180.KB911786_gene91	8.614e-56	200.0	COG5646@1|root,COG5646@2|Bacteria,2IINN@201174|Actinobacteria	201174|Actinobacteria	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS2_k127_2388257_12	1150864.MILUP08_45942	5.341e-62	225.0	COG3544@1|root,COG3544@2|Bacteria,2GMGR@201174|Actinobacteria,4DDG7@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
TLS2_k127_2388257_10	369723.Strop_3654	1.843e-78	269.0	COG0515@1|root,COG0515@2|Bacteria,2GTP2@201174|Actinobacteria,4D8MW@85008|Micromonosporales	201174|Actinobacteria	KLT	Protein of unknown function (DUF3105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3105
TLS2_k127_2388257_0	219305.MCAG_01767	7.862e-258	804.0	COG0018@1|root,COG0018@2|Bacteria,2GKQ3@201174|Actinobacteria,4D979@85008|Micromonosporales	201174|Actinobacteria	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
TLS2_k127_2388257_2	263358.VAB18032_29706	5.716e-224	702.0	COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria,4DA1I@85008|Micromonosporales	201174|Actinobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS2_k127_2388257_3	1246995.AFR_37485	1.28e-195	620.0	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,4D8CZ@85008|Micromonosporales	201174|Actinobacteria	E	homoserine dehydrogenase	hom	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294	ACT,Homoserine_dh,NAD_binding_3
TLS2_k127_2388257_4	33876.JNXY01000039_gene6696	1.656e-175	556.0	COG0498@1|root,COG0498@2|Bacteria,2GJ5F@201174|Actinobacteria,4D98N@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_2388257_5	263358.VAB18032_29681	2.302e-147	477.0	COG0477@1|root,COG2814@2|Bacteria,2HX42@201174|Actinobacteria,4D8CP@85008|Micromonosporales	201174|Actinobacteria	EGP	Major facilitator superfamily	bacE	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS2_k127_2388257_8	1136417.AZWE01000001_gene3720	6.473e-97	327.0	COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria,4DBAU@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_2388257_1	644283.Micau_5152	7.908e-234	744.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4D9K3@85008|Micromonosporales	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
TLS2_k127_2417595_2	1463917.JODC01000007_gene7465	3.379e-169	536.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_2417595_0	33898.JRHJ01000069_gene7045	5.757e-228	713.0	COG0402@1|root,COG0402@2|Bacteria,2GNUN@201174|Actinobacteria	201174|Actinobacteria	F	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_2417595_7	1463917.JODC01000007_gene7463	5.936e-116	383.0	COG0662@1|root,COG0662@2|Bacteria,2GN99@201174|Actinobacteria	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2417595_9	351607.Acel_1040	2.344e-77	266.0	COG1028@1|root,COG1028@2|Bacteria,2I6UQ@201174|Actinobacteria,4EVQ5@85013|Frankiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
TLS2_k127_2417595_8	1463917.JODC01000007_gene7461	6.719e-92	310.0	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria	201174|Actinobacteria	I	3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_2417595_5	35754.JNYJ01000021_gene477	1.602e-151	508.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4DH8I@85008|Micromonosporales	201174|Actinobacteria	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
TLS2_k127_2417595_1	1449976.KALB_2819	3.474e-220	694.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria,4DZ2J@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TLS2_k127_2417595_3	33876.JNXY01000008_gene8504	2.944e-161	546.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4D8FP@85008|Micromonosporales	201174|Actinobacteria	T	Signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4
TLS2_k127_2417595_11	35754.JNYJ01000049_gene7881	1.047e-19	93.0	2EKMU@1|root,33EBJ@2|Bacteria,2GTFT@201174|Actinobacteria,4DFPK@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_6
TLS2_k127_2417595_6	263358.VAB18032_11120	1.396e-136	444.0	COG2133@1|root,COG2133@2|Bacteria,2GISM@201174|Actinobacteria,4D8DH@85008|Micromonosporales	201174|Actinobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS2_k127_2417595_4	263358.VAB18032_11115	1.556e-159	519.0	COG1408@1|root,COG1408@2|Bacteria,2GM8M@201174|Actinobacteria,4DAPG@85008|Micromonosporales	201174|Actinobacteria	S	Metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
TLS2_k127_2417595_10	1123065.ATWL01000009_gene1032	1.865e-20	107.0	COG1520@1|root,COG3537@1|root,COG1520@2|Bacteria,COG3537@2|Bacteria,2IFG3@201174|Actinobacteria	201174|Actinobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2417595_13	1157632.AQWQ01000010_gene610	6.883e-05	56.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	bpr	GO:0005575,GO:0005576	-	ko:K13276	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Inhibitor_I9,Malectin,PKD,Peptidase_M6,Peptidase_S8
TLS2_k127_2417595_12	28042.GU90_02010	4.257e-07	52.0	COG3507@1|root,COG3537@1|root,COG3507@2|Bacteria,COG3537@2|Bacteria,2I3T5@201174|Actinobacteria,4E0WN@85010|Pseudonocardiales	201174|Actinobacteria	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
TLS2_k127_2417643_2	28042.GU90_02010	3.093e-07	52.0	COG3507@1|root,COG3537@1|root,COG3507@2|Bacteria,COG3537@2|Bacteria,2I3T5@201174|Actinobacteria,4E0WN@85010|Pseudonocardiales	201174|Actinobacteria	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
TLS2_k127_2417643_0	926550.CLDAP_27190	2.539e-131	470.0	COG1404@1|root,COG5640@1|root,COG1404@2|Bacteria,COG5640@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	vpr	GO:0005575,GO:0005576	3.4.21.4	ko:K01312,ko:K14647	ko02024,ko04080,ko04972,ko04974,ko05164,map02024,map04080,map04972,map04974,map05164	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110,ko04147	-	-	-	FlgD_ig,Inhibitor_I9,PA,Peptidase_S8,SLH,Trypsin,VCBS
TLS2_k127_2417643_1	945713.IALB_1488	3.451e-55	224.0	COG3291@1|root,COG4409@1|root,COG4935@1|root,COG3291@2|Bacteria,COG4409@2|Bacteria,COG4935@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	wcoB	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Beta_helix,PKD,Reprolysin_4
TLS2_k127_2428764_15	1380393.JHVP01000004_gene598	4.136e-06	57.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
TLS2_k127_2428764_1	1236902.ANAS01000031_gene2853	3.409e-220	689.0	COG2224@1|root,COG2224@2|Bacteria,2GNAY@201174|Actinobacteria,4EG9A@85012|Streptosporangiales	201174|Actinobacteria	C	Isocitrate lyase family	aceA	GO:0001101,GO:0001666,GO:0003674,GO:0003824,GO:0004451,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0006950,GO:0008150,GO:0008152,GO:0009268,GO:0009405,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0010033,GO:0010034,GO:0010447,GO:0016020,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0019899,GO:0032787,GO:0033554,GO:0033993,GO:0035375,GO:0036293,GO:0036294,GO:0042221,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046421,GO:0046487,GO:0046677,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0070482,GO:0070542,GO:0070887,GO:0071453,GO:0071456,GO:0071704,GO:0071944,GO:0072350,GO:0075136,GO:0075141,GO:1901700	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
TLS2_k127_2428764_4	1089546.AQUI01000002_gene1425	5.962e-211	664.0	COG1396@1|root,COG3800@1|root,COG1396@2|Bacteria,COG3800@2|Bacteria,2GMWU@201174|Actinobacteria,40841@622450|Actinopolysporales	201174|Actinobacteria	K	Pfam:DUF955	hipB	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31,Peptidase_M78
TLS2_k127_2428764_3	479432.Sros_2261	1.771e-213	676.0	COG2225@1|root,COG2225@2|Bacteria,2GJGP@201174|Actinobacteria,4EHIQ@85012|Streptosporangiales	201174|Actinobacteria	C	Malate synthase	aceB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
TLS2_k127_2428764_5	543632.JOJL01000007_gene5432	4.498e-174	561.0	COG1472@1|root,COG1472@2|Bacteria,2GM43@201174|Actinobacteria,4DBZX@85008|Micromonosporales	201174|Actinobacteria	G	Glycoside hydrolase family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
TLS2_k127_2428764_2	33876.JNXY01000009_gene8988	1.143e-219	691.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4D9VK@85008|Micromonosporales	201174|Actinobacteria	E	peptidase M24B X-Pro dipeptidase aminopeptidase domain protein	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
TLS2_k127_2428764_0	644283.Micau_4256	0.0	1111.0	COG0367@1|root,COG0367@2|Bacteria,2GJIM@201174|Actinobacteria,4DAUN@85008|Micromonosporales	201174|Actinobacteria	E	asparagine synthase (glutamine-hydrolyzing)	asnB	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
TLS2_k127_2428764_14	29306.JOBE01000001_gene2623	2.564e-09	66.0	2BBSQ@1|root,325AW@2|Bacteria,2HAF8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2428764_11	1136417.AZWE01000022_gene2667	1.112e-36	154.0	29YKI@1|root,30KFU@2|Bacteria,2HWZE@201174|Actinobacteria,4DKTN@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2428764_9	219305.MCAG_01040	7.726e-94	321.0	COG0491@1|root,COG0491@2|Bacteria,2GMHY@201174|Actinobacteria,4DD4F@85008|Micromonosporales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	blaB3	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_2428764_10	644283.Micau_4249	3.032e-48	176.0	COG5496@1|root,COG5496@2|Bacteria,2IKZP@201174|Actinobacteria,4DE8F@85008|Micromonosporales	201174|Actinobacteria	S	Thioesterase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_2428764_6	1464048.JNZS01000036_gene1989	3.519e-142	459.0	COG0671@1|root,COG0671@2|Bacteria,2IAXK@201174|Actinobacteria,4DA2G@85008|Micromonosporales	201174|Actinobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
TLS2_k127_2428764_8	1121946.AUAX01000052_gene8123	4.062e-95	331.0	2BNZ3@1|root,32HP7@2|Bacteria,2IIYD@201174|Actinobacteria,4DM3M@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2428764_7	1464048.JNZS01000036_gene1988	1.095e-132	449.0	COG3428@1|root,COG3428@2|Bacteria,2GJCD@201174|Actinobacteria,4D98H@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
TLS2_k127_2428764_13	1381751.JAJB01000027_gene1418	1.589e-28	121.0	COG3402@1|root,COG3402@2|Bacteria,2IR88@201174|Actinobacteria,4FAA7@85019|Brevibacteriaceae	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
TLS2_k127_2428764_12	1206101.AZXC01000002_gene6225	3.103e-29	119.0	2E3SR@1|root,32YQ8@2|Bacteria,2GQKG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2524075_15	1464048.JNZS01000004_gene1328	1.421e-54	202.0	COG1579@1|root,COG1579@2|Bacteria,2I2XU@201174|Actinobacteria,4DD8T@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
TLS2_k127_2524075_10	543632.JOJL01000037_gene6465	1.531e-73	253.0	COG2220@1|root,COG2220@2|Bacteria,2GNHK@201174|Actinobacteria,4DDC1@85008|Micromonosporales	201174|Actinobacteria	S	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
TLS2_k127_2524075_8	219305.MCAG_03610	1.719e-76	264.0	COG2105@1|root,COG2105@2|Bacteria,2I2XV@201174|Actinobacteria,4DDME@85008|Micromonosporales	201174|Actinobacteria	S	Gamma-glutamyl cyclotransferase, AIG2-like	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2
TLS2_k127_2524075_3	134676.ACPL_7730	1.302e-214	676.0	COG1249@1|root,COG1249@2|Bacteria,2GMP7@201174|Actinobacteria,4D9EN@85008|Micromonosporales	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpdA	GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044419,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051704,GO:0055114,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_2524075_6	1246995.AFR_35710	5.633e-113	377.0	COG1253@1|root,COG1253@2|Bacteria,2GJ8X@201174|Actinobacteria,4DAUZ@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
TLS2_k127_2524075_4	263358.VAB18032_12200	1.662e-164	528.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4D9WX@85008|Micromonosporales	201174|Actinobacteria	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_2524075_17	1394178.AWOO02000013_gene7939	1.999e-24	111.0	COG1846@1|root,COG1846@2|Bacteria,2GRCT@201174|Actinobacteria,4EK6Q@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_2524075_2	1121946.AUAX01000005_gene5230	8.598e-309	967.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4DB4W@85008|Micromonosporales	201174|Actinobacteria	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF
TLS2_k127_2524075_16	390989.JOEG01000009_gene1176	2.053e-25	106.0	COG0267@1|root,COG0267@2|Bacteria,2GQFG@201174|Actinobacteria,4DFK0@85008|Micromonosporales	201174|Actinobacteria	J	Ribosomal protein L33	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
TLS2_k127_2524075_12	391037.Sare_4333	6.185e-68	234.0	COG2030@1|root,COG2030@2|Bacteria,2GMVC@201174|Actinobacteria,4DD0I@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the UPF0336 family	hadA	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
TLS2_k127_2524075_14	1121272.KB903250_gene3023	1.003e-54	195.0	COG2030@1|root,COG2030@2|Bacteria,2IFCJ@201174|Actinobacteria,4DE1R@85008|Micromonosporales	201174|Actinobacteria	I	PFAM MaoC domain protein dehydratase	hadB	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
TLS2_k127_2524075_18	391037.Sare_4331	1.271e-20	97.0	COG0690@1|root,COG0690@2|Bacteria,2GQFP@201174|Actinobacteria,4DF5J@85008|Micromonosporales	201174|Actinobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
TLS2_k127_2524075_7	1246995.AFR_04425	1.59e-108	358.0	COG0250@1|root,COG0250@2|Bacteria,2GJFW@201174|Actinobacteria,4D9HW@85008|Micromonosporales	201174|Actinobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusG
TLS2_k127_2524075_9	644283.Micau_5542	4.074e-74	253.0	COG0080@1|root,COG0080@2|Bacteria,2IFCK@201174|Actinobacteria,4DCKR@85008|Micromonosporales	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
TLS2_k127_2524075_5	263358.VAB18032_01220	2.941e-120	392.0	COG0081@1|root,COG0081@2|Bacteria,2GM51@201174|Actinobacteria,4D981@85008|Micromonosporales	201174|Actinobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
TLS2_k127_2524075_11	35754.JNYJ01000004_gene5988	3.3e-69	242.0	COG0244@1|root,COG0244@2|Bacteria,2GM0V@201174|Actinobacteria,4DBD7@85008|Micromonosporales	201174|Actinobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
TLS2_k127_2524075_13	263358.VAB18032_01210	5.045e-57	201.0	COG0222@1|root,COG0222@2|Bacteria,2IKNW@201174|Actinobacteria,4DEHN@85008|Micromonosporales	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
TLS2_k127_2524075_0	644283.Micau_5536	0.0	2130.0	COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria,4D94I@85008|Micromonosporales	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
TLS2_k127_2524075_1	263358.VAB18032_01200	0.0	1576.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4DA6K@85008|Micromonosporales	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
TLS2_k127_2544106_5	649831.L083_0487	1.794e-215	683.0	COG1409@1|root,COG1409@2|Bacteria,2GP1M@201174|Actinobacteria,4DBV7@85008|Micromonosporales	201174|Actinobacteria	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS2_k127_2544106_7	263358.VAB18032_06395	2.02e-173	556.0	COG0470@1|root,COG0470@2|Bacteria,2GJ8C@201174|Actinobacteria,4DB0J@85008|Micromonosporales	201174|Actinobacteria	L	DNA polymerase III	holB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
TLS2_k127_2544106_4	1121946.AUAX01000003_gene1674	3e-258	816.0	COG0125@1|root,COG2211@1|root,COG0125@2|Bacteria,COG2211@2|Bacteria,2GNTI@201174|Actinobacteria,4DA19@85008|Micromonosporales	201174|Actinobacteria	FG	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_3,Thymidylate_kin
TLS2_k127_2544106_18	649831.L083_0468	4.13e-87	293.0	COG1309@1|root,COG1309@2|Bacteria,2IDJT@201174|Actinobacteria,4D90N@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_2544106_0	263358.VAB18032_06365	0.0	1364.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria,4DB10@85008|Micromonosporales	201174|Actinobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
TLS2_k127_2544106_24	1150864.MILUP08_40413	2.825e-52	192.0	2EE2C@1|root,337X2@2|Bacteria,2GNPT@201174|Actinobacteria,4DDWK@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2544106_3	263358.VAB18032_06345	0.0	1103.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,4D8K1@85008|Micromonosporales	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS2_k127_2544106_29	543632.JOJL01000028_gene166	7.155e-34	137.0	COG2172@1|root,COG2172@2|Bacteria,2IHNR@201174|Actinobacteria,4DDS8@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
TLS2_k127_2544106_25	644283.Micau_0443	1.502e-42	158.0	COG1366@1|root,COG1366@2|Bacteria,2IHQG@201174|Actinobacteria,4DE05@85008|Micromonosporales	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
TLS2_k127_2544106_1	219305.MCAG_03225	0.0	1124.0	COG1205@1|root,COG1205@2|Bacteria,2GJJ6@201174|Actinobacteria,4D8Z2@85008|Micromonosporales	201174|Actinobacteria	L	DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
TLS2_k127_2544106_16	1043493.BBLU01000014_gene1214	6.373e-97	325.0	COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the SAICAR synthetase family	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01923,ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
TLS2_k127_2544106_32	1121946.AUAX01000003_gene1684	5.182e-18	95.0	2DRBM@1|root,33B4F@2|Bacteria,2GXTD@201174|Actinobacteria,4DFN3@85008|Micromonosporales	201174|Actinobacteria	S	TIGRFAM helicase secretion neighborhood TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Tad
TLS2_k127_2544106_31	644283.Micau_0438	6.093e-28	121.0	2EGB2@1|root,33A2X@2|Bacteria,2HUS6@201174|Actinobacteria,4DFWM@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS2_k127_2544106_33	391037.Sare_4418	2.824e-15	77.0	2EHCF@1|root,33B4A@2|Bacteria,2I1J5@201174|Actinobacteria,4DGKF@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF4244)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4244
TLS2_k127_2544106_23	219305.MCAG_03220	7.54e-54	205.0	COG2064@1|root,COG2064@2|Bacteria,2IQE9@201174|Actinobacteria,4DDX7@85008|Micromonosporales	201174|Actinobacteria	NU	type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_2544106_28	263358.VAB18032_06290	2.261e-37	156.0	COG4965@1|root,COG4965@2|Bacteria,2I0QF@201174|Actinobacteria,4DE6T@85008|Micromonosporales	201174|Actinobacteria	U	Type ii secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	-
TLS2_k127_2544106_9	1464048.JNZS01000013_gene3224	1.386e-160	518.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4D96F@85008|Micromonosporales	201174|Actinobacteria	U	Type ii secretion system protein e	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS2_k127_2544106_14	644283.Micau_0433	2.205e-118	396.0	COG1192@1|root,COG1192@2|Bacteria,2I44R@201174|Actinobacteria,4DMJT@85008|Micromonosporales	201174|Actinobacteria	D	Involved in chromosome partitioning	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
TLS2_k127_2544106_12	219305.MCAG_03212	8.761e-123	400.0	COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4D9E5@85008|Micromonosporales	201174|Actinobacteria	E	HAD-superfamily subfamily IB hydrolase, TIGR01490	serB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	HAD
TLS2_k127_2544106_30	390989.JOEG01000010_gene479	9.532e-31	131.0	2EUX2@1|root,33NCD@2|Bacteria,2HX0V@201174|Actinobacteria,4DKX1@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2544106_21	219305.MCAG_03211	4.389e-75	262.0	COG3177@1|root,COG3177@2|Bacteria,2GIT8@201174|Actinobacteria,4D9EQ@85008|Micromonosporales	201174|Actinobacteria	S	Filamentation induced by cAMP protein fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic
TLS2_k127_2544106_2	35754.JNYJ01000036_gene3758	0.0	1122.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,4DADS@85008|Micromonosporales	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_2544106_17	477641.MODMU_4276	1.747e-91	306.0	2DBMB@1|root,2Z9Y8@2|Bacteria,2I4DG@201174|Actinobacteria,4EUB8@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
TLS2_k127_2544106_15	35754.JNYJ01000036_gene3761	1.393e-114	380.0	COG4927@1|root,COG4927@2|Bacteria,2I9GM@201174|Actinobacteria,4DC2T@85008|Micromonosporales	201174|Actinobacteria	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	ko:K19200	ko00311,ko01100,ko01130,map00311,map01100,map01130	-	-	-	ko00000,ko00001,ko01002	-	-	-	AAT
TLS2_k127_2544106_8	369723.Strop_4044	1.522e-161	512.0	COG0596@1|root,COG0596@2|Bacteria,2GJDM@201174|Actinobacteria,4DAPQ@85008|Micromonosporales	201174|Actinobacteria	S	Alpha beta hydrolase	ephE	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_2544106_22	219305.MCAG_03205	1.506e-56	198.0	2EI3Z@1|root,33BVD@2|Bacteria,2IHSZ@201174|Actinobacteria,4DEKB@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2544106_11	1121272.KB903293_gene7369	1.412e-145	478.0	COG3266@1|root,COG3266@2|Bacteria,2GTJ5@201174|Actinobacteria,4D9GW@85008|Micromonosporales	201174|Actinobacteria	S	SseB protein N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SseB
TLS2_k127_2544106_27	649831.L083_0438	6.366e-39	150.0	COG1950@1|root,COG1950@2|Bacteria,2IHP5@201174|Actinobacteria,4DF4S@85008|Micromonosporales	201174|Actinobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
TLS2_k127_2544106_26	33876.JNXY01000005_gene8653	1.851e-41	162.0	COG5662@1|root,COG5662@2|Bacteria,2GNCC@201174|Actinobacteria,4D9EP@85008|Micromonosporales	201174|Actinobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_2544106_19	263358.VAB18032_06195	6.378e-83	278.0	COG1595@1|root,COG1595@2|Bacteria,2GM3E@201174|Actinobacteria,4DAU0@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigL	GO:0000988,GO:0000990,GO:0003674,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043254,GO:0044087,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_2544106_20	369723.Strop_4050	4.306e-82	284.0	COG1414@1|root,COG1414@2|Bacteria,2GP0G@201174|Actinobacteria,4D8NG@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	ssfR	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS2_k127_2544106_13	1150864.MILUP08_40371	1.051e-120	400.0	COG2223@1|root,COG2223@2|Bacteria,2I3SI@201174|Actinobacteria,4DMP3@85008|Micromonosporales	201174|Actinobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_2544106_10	644283.Micau_0409	9.954e-149	477.0	COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4D9ZW@85008|Micromonosporales	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	hepT	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_2544106_6	1246995.AFR_01720	1.264e-181	575.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4DBH5@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_2601463_1	1150864.MILUP08_44461	4.478e-149	480.0	COG3173@1|root,COG3173@2|Bacteria,2GKUU@201174|Actinobacteria,4DACV@85008|Micromonosporales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_2601463_2	1120949.KB903306_gene7647	2.842e-126	411.0	COG1194@1|root,COG1194@2|Bacteria,2GJD9@201174|Actinobacteria,4D9MC@85008|Micromonosporales	201174|Actinobacteria	L	FES	mutY	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
TLS2_k127_2601463_4	644283.Micau_5847	5.937e-63	230.0	COG2716@1|root,COG2716@2|Bacteria,2IGKE@201174|Actinobacteria,4DCUR@85008|Micromonosporales	201174|Actinobacteria	E	Amino acid-binding act domain protein	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
TLS2_k127_2601463_3	644283.Micau_5846	1.136e-71	246.0	COG0242@1|root,COG0242@2|Bacteria,2HMJS@201174|Actinobacteria,4DBU9@85008|Micromonosporales	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TLS2_k127_2601463_5	1121272.KB903263_gene579	5.902e-38	150.0	2E5CN@1|root,3304R@2|Bacteria,2I2XG@201174|Actinobacteria,4DE6J@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2601463_0	644283.Micau_5843	4.215e-184	582.0	COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria,4DA92@85008|Micromonosporales	201174|Actinobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
TLS2_k127_260287_1	263358.VAB18032_27521	1.423e-270	840.0	COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria,4D9Q5@85008|Micromonosporales	201174|Actinobacteria	E	glutamine synthetase	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS2_k127_260287_0	1150864.MILUP08_45287	4.35e-275	864.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2GK2C@201174|Actinobacteria,4DBKE@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
TLS2_k127_260287_2	1464048.JNZS01000006_gene4090	3.372e-131	423.0	COG0413@1|root,COG0413@2|Bacteria,2GJP6@201174|Actinobacteria,4DBBA@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TLS2_k127_260287_4	1121272.KB903290_gene4650	1.904e-53	198.0	COG0517@1|root,COG0517@2|Bacteria,2IM3K@201174|Actinobacteria,4DEGD@85008|Micromonosporales	201174|Actinobacteria	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_260287_3	263358.VAB18032_27541	4.951e-98	325.0	COG2085@1|root,COG2085@2|Bacteria,2GMZ5@201174|Actinobacteria,4DBGU@85008|Micromonosporales	201174|Actinobacteria	S	NADPH-dependent F420 reductase	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
TLS2_k127_260287_6	1476876.JOJO01000044_gene1251	2.195e-12	72.0	2EK8X@1|root,33DZ6@2|Bacteria,2GWJW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_260287_7	35754.JNYJ01000025_gene8919	3.954e-07	53.0	COG3237@1|root,COG3237@2|Bacteria,2GRDY@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the UPF0337 (CsbD) family	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
TLS2_k127_2696408_3	644283.Micau_1663	3.983e-130	424.0	COG1175@1|root,COG1175@2|Bacteria,2GMV4@201174|Actinobacteria,4D9ZB@85008|Micromonosporales	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10241	ko02010,map02010	M00206	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.23	-	-	BPD_transp_1
TLS2_k127_2696408_4	644283.Micau_1664	1.079e-126	412.0	COG0395@1|root,COG0395@2|Bacteria,2GK1V@201174|Actinobacteria,4DBF1@85008|Micromonosporales	201174|Actinobacteria	G	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026,ko:K10242	ko02010,map02010	M00206,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.23	-	-	BPD_transp_1
TLS2_k127_2696408_1	1150864.MILUP08_41767	5.002e-205	652.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria,4DAN2@85008|Micromonosporales	201174|Actinobacteria	G	Beta-glucosidase	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
TLS2_k127_2696408_2	33876.JNXY01000033_gene2260	2.196e-157	509.0	COG1609@1|root,COG1609@2|Bacteria,2GJV7@201174|Actinobacteria,4D8Q5@85008|Micromonosporales	201174|Actinobacteria	K	transcriptional	cebR	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
TLS2_k127_2696408_5	1869.MB27_19795	3.774e-93	311.0	COG0317@1|root,COG0317@2|Bacteria,2GNRE@201174|Actinobacteria,4D9XY@85008|Micromonosporales	201174|Actinobacteria	KT	Amino acid-binding act domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
TLS2_k127_2696408_0	369723.Strop_2136	1.128e-222	695.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4DBIY@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the citrate synthase family	gltA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS2_k127_2762397_21	986075.CathTA2_1324	1.402e-58	219.0	COG1638@1|root,COG1638@2|Bacteria,1UY2X@1239|Firmicutes,4HCVD@91061|Bacilli	91061|Bacilli	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_2762397_1	263358.VAB18032_10830	0.0	1125.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_127,Glyco_hydro_43
TLS2_k127_2762397_8	1120949.KB903304_gene6882	1.557e-137	458.0	COG3629@1|root,COG3629@2|Bacteria,2GM4U@201174|Actinobacteria	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD
TLS2_k127_2762397_25	196162.Noca_4891	1.502e-37	145.0	COG2114@1|root,COG2114@2|Bacteria,2IQEQ@201174|Actinobacteria	201174|Actinobacteria	T	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
TLS2_k127_2762397_28	479433.Caci_6238	1.213e-28	125.0	2DFNF@1|root,2ZSER@2|Bacteria,2HAWM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2762397_3	710111.FraQA3DRAFT_0729	3.493e-290	964.0	COG3209@1|root,COG3209@2|Bacteria,2GK1D@201174|Actinobacteria,4EW27@85013|Frankiales	201174|Actinobacteria	M	TIGRFAM YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
TLS2_k127_2762397_10	710111.FraQA3DRAFT_0730	3.644e-131	458.0	COG0457@1|root,COG0457@2|Bacteria	710111.FraQA3DRAFT_0730|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2762397_12	1172180.KB911800_gene3319	6.384e-127	422.0	COG2120@1|root,COG2120@2|Bacteria,2GMVD@201174|Actinobacteria	201174|Actinobacteria	H	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_2762397_17	35754.JNYJ01000009_gene1849	2.779e-93	315.0	COG0657@1|root,COG0657@2|Bacteria,2IHD5@201174|Actinobacteria,4DE35@85008|Micromonosporales	201174|Actinobacteria	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
TLS2_k127_2762397_5	345341.KUTG_02460	4.941e-204	645.0	COG4942@1|root,COG4942@2|Bacteria,2GW48@201174|Actinobacteria	201174|Actinobacteria	D	Protein of unknown function (DUF3375)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3375
TLS2_k127_2762397_20	345341.KUTG_02461	7.816e-78	265.0	2CB46@1|root,31GHU@2|Bacteria,2ID3Z@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4194
TLS2_k127_2762397_0	345341.KUTG_02462	0.0	1233.0	COG4913@1|root,COG4913@2|Bacteria,2GMIP@201174|Actinobacteria,4E8QQ@85010|Pseudonocardiales	201174|Actinobacteria	S	P-loop containing region of AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
TLS2_k127_2762397_11	345341.KUTG_02463	3.411e-128	426.0	COG4924@1|root,COG4924@2|Bacteria,2IB33@201174|Actinobacteria,4EA8E@85010|Pseudonocardiales	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2220,DUF3322
TLS2_k127_2762397_27	391037.Sare_1071	1.136e-32	130.0	COG1091@1|root,COG1091@2|Bacteria,2HUB0@201174|Actinobacteria,4DDUS@85008|Micromonosporales	201174|Actinobacteria	M	dTDP-4-dehydrorhamnose reductase	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
TLS2_k127_2762397_7	356851.JOAN01000021_gene2357	5.513e-170	543.0	COG2367@1|root,COG2367@2|Bacteria,2I9TI@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
TLS2_k127_2762397_24	1246995.AFR_10950	7.049e-38	151.0	COG1309@1|root,COG1309@2|Bacteria,2IMEB@201174|Actinobacteria,4DFTR@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_8,TetR_N
TLS2_k127_2762397_16	1137269.AZWL01000025_gene27	2.436e-97	336.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_2762397_31	479432.Sros_4340	7.537e-16	92.0	2DS3Z@1|root,33EEF@2|Bacteria,2GZS2@201174|Actinobacteria	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS2_k127_2762397_14	1033730.CAHG01000007_gene2702	4.146e-107	358.0	COG3739@1|root,COG3739@2|Bacteria,2IAF8@201174|Actinobacteria,4DN4S@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF817)	-	-	-	-	-	-	-	-	-	-	-	-	DUF817
TLS2_k127_2762397_30	1206737.BAGF01000147_gene5864	5.889e-16	92.0	COG2764@1|root,COG2764@2|Bacteria,2I46Y@201174|Actinobacteria,4FXR8@85025|Nocardiaceae	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2762397_33	408672.NBCG_00629	7.254e-08	60.0	COG2197@1|root,COG3267@1|root,COG2197@2|Bacteria,COG3267@2|Bacteria,2I3QJ@201174|Actinobacteria,4DQH2@85009|Propionibacteriales	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_2762397_6	1206101.AZXC01000019_gene1434	7.834e-173	548.0	COG0500@1|root,COG2226@2|Bacteria,2I3SA@201174|Actinobacteria	201174|Actinobacteria	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_2762397_2	1206101.AZXC01000019_gene1433	0.0	1110.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
TLS2_k127_2762397_18	2074.JNYD01000022_gene1438	2.122e-92	312.0	COG2120@1|root,COG2120@2|Bacteria,2IDT2@201174|Actinobacteria,4EBAF@85010|Pseudonocardiales	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K22135	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_2762397_19	1136417.AZWE01000004_gene4525	5.316e-83	281.0	COG1309@1|root,COG1309@2|Bacteria,2GMZ1@201174|Actinobacteria,4DABC@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_2762397_9	1136417.AZWE01000004_gene4524	3.095e-132	436.0	COG2020@1|root,COG2020@2|Bacteria,2IN0C@201174|Actinobacteria,4DC45@85008|Micromonosporales	201174|Actinobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TLS2_k127_2762397_15	391037.Sare_2473	3.449e-98	330.0	2DTT8@1|root,32UVV@2|Bacteria,2IKAI@201174|Actinobacteria,4DD3W@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2762397_13	219305.MCAG_03536	9.557e-118	385.0	COG2267@1|root,COG2267@2|Bacteria,2GM56@201174|Actinobacteria,4DBDE@85008|Micromonosporales	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_2762397_26	1150864.MILUP08_46842	1.925e-36	143.0	COG2247@1|root,COG4733@1|root,COG2247@2|Bacteria,COG4733@2|Bacteria,2I4VD@201174|Actinobacteria,4DHGI@85008|Micromonosporales	201174|Actinobacteria	M	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
TLS2_k127_2762397_4	219305.MCAG_03905	1.383e-270	858.0	COG1672@1|root,COG2197@1|root,COG1672@2|Bacteria,COG2197@2|Bacteria,2I3QJ@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_2762397_32	1120960.ATXG01000001_gene1159	6.042e-09	64.0	2AB2A@1|root,310G1@2|Bacteria,2HC30@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2798382_4	1121272.KB903272_gene185	1.937e-231	735.0	COG4677@1|root,COG4677@2|Bacteria,2GNHF@201174|Actinobacteria,4DH99@85008|Micromonosporales	201174|Actinobacteria	G	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
TLS2_k127_2798382_16	391037.Sare_1101	2.626e-29	122.0	2EGDD@1|root,33A58@2|Bacteria,2GR3X@201174|Actinobacteria,4DEMF@85008|Micromonosporales	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
TLS2_k127_2798382_17	591167.Sfla_5141	1.874e-12	74.0	2ATH5@1|root,31J0W@2|Bacteria,2IQ8W@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF202
TLS2_k127_2798382_12	219305.MCAG_04147	1.155e-47	175.0	COG2149@1|root,COG2149@2|Bacteria,2GQU9@201174|Actinobacteria,4DF5R@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF202)	yidH	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
TLS2_k127_2798382_10	644283.Micau_1253	1.842e-129	419.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,4D8MJ@85008|Micromonosporales	201174|Actinobacteria	C	Electron transfer flavoprotein	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
TLS2_k127_2798382_8	263358.VAB18032_11030	1.654e-141	458.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,4DA2B@85008|Micromonosporales	201174|Actinobacteria	C	electron transfer flavoprotein, alpha subunit	etfA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TLS2_k127_2798382_6	219305.MCAG_04152	7.363e-186	587.0	COG1104@1|root,COG1104@2|Bacteria,2GKUT@201174|Actinobacteria,4DB1C@85008|Micromonosporales	201174|Actinobacteria	E	Cysteine desulfurase	iscS	GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS2_k127_2798382_5	1150864.MILUP08_41352	2.676e-189	598.0	COG0482@1|root,COG0482@2|Bacteria,2GIUQ@201174|Actinobacteria,4DAK3@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TLS2_k127_2798382_11	1283299.AUKG01000002_gene4229	1.592e-62	221.0	COG0590@1|root,COG0590@2|Bacteria,2INAI@201174|Actinobacteria	201174|Actinobacteria	FJ	deaminase	guaD	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
TLS2_k127_2798382_9	1150864.MILUP08_41353	1.927e-136	441.0	COG0620@1|root,COG0620@2|Bacteria,2GMPS@201174|Actinobacteria,4D9B2@85008|Micromonosporales	201174|Actinobacteria	E	Cobalamin-independent synthase, Catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
TLS2_k127_2798382_15	35754.JNYJ01000021_gene388	3.321e-33	142.0	COG0346@1|root,COG0346@2|Bacteria,2IQB4@201174|Actinobacteria,4DETT@85008|Micromonosporales	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_2798382_0	1120949.KB903356_gene8769	2.493e-320	993.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,4D8P7@85008|Micromonosporales	201174|Actinobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
TLS2_k127_2798382_3	33876.JNXY01000008_gene8499	1.08e-243	771.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4DARM@85008|Micromonosporales	201174|Actinobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
TLS2_k127_2798382_13	1121946.AUAX01000001_gene2506	6.176e-39	152.0	COG0721@1|root,COG0721@2|Bacteria,2IQJN@201174|Actinobacteria,4DEPX@85008|Micromonosporales	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
TLS2_k127_2798382_2	219305.MCAG_04162	7.32e-251	783.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4D9RM@85008|Micromonosporales	201174|Actinobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_2798382_14	1122182.KB903837_gene3846	1.942e-35	144.0	COG0580@1|root,COG0580@2|Bacteria,2GKK3@201174|Actinobacteria,4DG5A@85008|Micromonosporales	201174|Actinobacteria	G	Major intrinsic protein	-	-	-	ko:K02440,ko:K06188,ko:K09874	-	-	-	-	ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.12,1.A.8.2	-	-	MIP
TLS2_k127_2798382_1	219305.MCAG_04163	9.432e-258	803.0	COG0064@1|root,COG0064@2|Bacteria,2GJJH@201174|Actinobacteria,4D95F@85008|Micromonosporales	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
TLS2_k127_2798382_7	1515746.HR45_11570	1.121e-145	492.0	COG1404@1|root,COG1404@2|Bacteria,1MVJE@1224|Proteobacteria,1RQ2M@1236|Gammaproteobacteria,2Q8GT@267890|Shewanellaceae	1236|Gammaproteobacteria	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,PA,PPC,Peptidase_S8
TLS2_k127_280581_17	1121272.KB903261_gene6050	1.203e-60	214.0	COG3255@1|root,COG3255@2|Bacteria,2IFWK@201174|Actinobacteria,4DDHJ@85008|Micromonosporales	201174|Actinobacteria	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
TLS2_k127_280581_14	33876.JNXY01000043_gene3783	9.43e-73	253.0	COG1226@1|root,COG1226@2|Bacteria,2GKNF@201174|Actinobacteria,4DDN3@85008|Micromonosporales	201174|Actinobacteria	P	Ion transport protein	kcsA	GO:0003674,GO:0005215,GO:0005216,GO:0005244,GO:0005249,GO:0005261,GO:0005267,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022832,GO:0022836,GO:0022838,GO:0022839,GO:0022843,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2
TLS2_k127_280581_3	219305.MCAG_03021	1.455e-179	594.0	COG0151@1|root,COG0151@2|Bacteria,2I2F5@201174|Actinobacteria,4D925@85008|Micromonosporales	201174|Actinobacteria	F	Belongs to the GARS family	purD	GO:0008150,GO:0040007	6.3.3.1,6.3.4.13	ko:K01945,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
TLS2_k127_280581_5	134676.ACPL_2657	4.221e-105	357.0	COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria,4D8RH@85008|Micromonosporales	201174|Actinobacteria	EGP	Transmembrane secretion effector	pimH	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS2_k127_280581_1	369723.Strop_0133	6.7e-244	760.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4D8SN@85008|Micromonosporales	201174|Actinobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
TLS2_k127_280581_10	219305.MCAG_03019	1.117e-87	298.0	COG1597@1|root,COG1597@2|Bacteria,2GP27@201174|Actinobacteria,4D8R6@85008|Micromonosporales	201174|Actinobacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS2_k127_280581_20	369723.Strop_0131	1.502e-51	188.0	2DMMI@1|root,32SFN@2|Bacteria,2IKP6@201174|Actinobacteria,4DMXM@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3151)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3151
TLS2_k127_280581_2	35754.JNYJ01000085_gene4087	5.198e-183	579.0	COG0191@1|root,COG0191@2|Bacteria,2GM5P@201174|Actinobacteria,4D9MX@85008|Micromonosporales	201174|Actinobacteria	G	Fructose-bisphosphate aldolase	fba	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
TLS2_k127_280581_26	356851.JOAN01000026_gene1848	1.996e-05	51.0	2BA9E@1|root,323PJ@2|Bacteria,2H8DX@201174|Actinobacteria,4DJSX@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_280581_4	1121272.KB903249_gene2362	8.858e-158	508.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,4DAS7@85008|Micromonosporales	201174|Actinobacteria	S	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS2_k127_280581_12	1050202.KB913024_gene3554	1.794e-79	276.0	COG2035@1|root,COG2035@2|Bacteria,2I8HU@201174|Actinobacteria,407XR@622450|Actinopolysporales	201174|Actinobacteria	S	Domain of unknown function (DUF368)	-	-	-	ko:K08974	-	-	-	-	ko00000	-	-	-	DUF368
TLS2_k127_280581_8	35754.JNYJ01000013_gene1242	3.738e-94	329.0	COG2304@1|root,COG2304@2|Bacteria,2GUB3@201174|Actinobacteria,4DAK1@85008|Micromonosporales	201174|Actinobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11,VWA
TLS2_k127_280581_15	35754.JNYJ01000013_gene1241	3.183e-72	250.0	COG0235@1|root,COG0235@2|Bacteria,2GNI6@201174|Actinobacteria,4DIRI@85008|Micromonosporales	201174|Actinobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
TLS2_k127_280581_19	219305.MCAG_03011	1.079e-56	199.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria,4DDMR@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator, arsr family	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
TLS2_k127_280581_11	644283.Micau_0177	1.985e-82	278.0	COG0461@1|root,COG0461@2|Bacteria,2GKUQ@201174|Actinobacteria,4DBWG@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
TLS2_k127_280581_9	1150864.MILUP08_40137	3.215e-92	310.0	COG0300@1|root,COG0300@2|Bacteria,2GKJE@201174|Actinobacteria,4DAQ1@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
TLS2_k127_280581_7	1121946.AUAX01000006_gene3309	5.753e-97	337.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4D8PV@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_280581_22	1150864.MILUP08_40135	9.09e-38	156.0	2FI4P@1|root,33CTS@2|Bacteria,2I57X@201174|Actinobacteria,4DMKS@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_280581_24	649831.L083_0111	8.511e-08	62.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3,Sensor
TLS2_k127_280581_25	1463821.JOGR01000004_gene2412	7.783e-07	59.0	2AIB8@1|root,318S9@2|Bacteria,2GSCN@201174|Actinobacteria,4F05Y@85014|Glycomycetales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_280581_0	644283.Micau_0165	0.0	1392.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4DAJ3@85008|Micromonosporales	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS2_k127_280581_18	1121272.KB903251_gene769	3.916e-58	206.0	COG0346@1|root,COG0346@2|Bacteria,2IFMD@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_280581_13	644283.Micau_4816	2.578e-77	270.0	COG2852@1|root,COG2852@2|Bacteria,2I3TW@201174|Actinobacteria	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_280581_23	1463825.JNXC01000001_gene5663	3.247e-28	121.0	COG4758@1|root,COG4758@2|Bacteria,2GXVR@201174|Actinobacteria,4E45X@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF1707)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1707
TLS2_k127_280581_16	33876.JNXY01000025_gene5345	9.019e-72	247.0	2EGSS@1|root,33AIW@2|Bacteria,2IFFF@201174|Actinobacteria,4DCS1@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_280581_21	1122611.KB903953_gene5725	4.494e-41	164.0	COG1309@1|root,COG1309@2|Bacteria,2IJB6@201174|Actinobacteria,4EM20@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_280581_6	35754.JNYJ01000077_gene7825	9.061e-101	335.0	COG1131@1|root,COG1131@2|Bacteria,2GTNE@201174|Actinobacteria,4DHW8@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K16907	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_2887394_7	263358.VAB18032_29351	1.87e-54	197.0	2ADQJ@1|root,313FX@2|Bacteria,2H0DG@201174|Actinobacteria,4DDU9@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2887394_2	405948.SACE_1946	1.553e-138	452.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4DX4S@85010|Pseudonocardiales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_2887394_1	1123322.KB904634_gene2290	1.099e-157	518.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_2887394_0	35754.JNYJ01000001_gene7308	5.139e-186	587.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4DA75@85008|Micromonosporales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	mmgC	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_2887394_5	35754.JNYJ01000001_gene7309	8.425e-90	300.0	COG1309@1|root,COG1309@2|Bacteria,2GNBI@201174|Actinobacteria,4DCB3@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
TLS2_k127_2887394_6	1394178.AWOO02000046_gene6464	3.535e-76	267.0	COG3315@1|root,COG3315@2|Bacteria,2I30H@201174|Actinobacteria	201174|Actinobacteria	Q	S-adenosyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_19
TLS2_k127_2887394_3	1120950.KB892746_gene3556	1.032e-109	361.0	COG1396@1|root,COG1396@2|Bacteria,2H35W@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
TLS2_k127_2887394_8	1120950.KB892746_gene3555	1.704e-25	106.0	2ENNX@1|root,33GA9@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF397
TLS2_k127_2887394_9	512565.AMIS_78900	3.078e-13	74.0	2BBX6@1|root,325FN@2|Bacteria,2HAM5@201174|Actinobacteria,4DKBF@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2887394_4	1464048.JNZS01000004_gene1558	1.395e-95	324.0	COG1629@1|root,COG4932@1|root,COG1629@2|Bacteria,COG4932@2|Bacteria,2GJ4T@201174|Actinobacteria,4DERA@85008|Micromonosporales	201174|Actinobacteria	M	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF3494
TLS2_k127_2898764_0	471852.Tcur_4663	7.8e-322	995.0	COG3211@1|root,COG3211@2|Bacteria,2GM1T@201174|Actinobacteria,4EGVT@85012|Streptosporangiales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF839)	-	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
TLS2_k127_2898765_10	1043493.BBLU01000014_gene1348	4.854e-65	236.0	2F548@1|root,33XRC@2|Bacteria,2H5BG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2898765_8	1125971.ASJB01000031_gene1250	1.677e-78	283.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,4DXNB@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
TLS2_k127_2898765_0	1464048.JNZS01000030_gene1849	3.133e-282	878.0	COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria,4D9N6@85008|Micromonosporales	201174|Actinobacteria	L	Type III restriction	sdrA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ResIII
TLS2_k127_2898765_12	1121272.KB903272_gene507	1.54e-32	130.0	2CAFG@1|root,32ZDZ@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3039)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3039
TLS2_k127_2898765_13	644283.Micau_1585	2.701e-27	114.0	2EGIC@1|root,33AAH@2|Bacteria,2IPNM@201174|Actinobacteria,4DEJF@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3099)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3099
TLS2_k127_2898765_9	455632.SGR_3531	1.577e-68	252.0	COG0177@1|root,COG0177@2|Bacteria,2GNE5@201174|Actinobacteria,41AEX@629295|Streptomyces griseus group	201174|Actinobacteria	L	HhH-GPD superfamily base excision DNA repair protein	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
TLS2_k127_2898765_5	1211815.CBYP010000002_gene1993	2.319e-134	443.0	COG2239@1|root,COG2239@2|Bacteria,2GMMK@201174|Actinobacteria	201174|Actinobacteria	P	transporter mgtE	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N,PRC
TLS2_k127_2898765_11	263358.VAB18032_12485	2.632e-55	202.0	COG1490@1|root,COG1490@2|Bacteria,2IKVR@201174|Actinobacteria,4DDCZ@85008|Micromonosporales	201174|Actinobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
TLS2_k127_2898765_4	1464048.JNZS01000030_gene1837	1.843e-135	437.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4DBGJ@85008|Micromonosporales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigA	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_2898765_1	644283.Micau_1571	4.106e-187	595.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4D92R@85008|Micromonosporales	201174|Actinobacteria	BQ	histone deacetylase	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
TLS2_k127_2898765_7	644283.Micau_1570	1.709e-99	336.0	COG2897@1|root,COG2897@2|Bacteria,2GMDR@201174|Actinobacteria,4D93S@85008|Micromonosporales	201174|Actinobacteria	P	Rhodanese domain protein	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS2_k127_2898765_6	35754.JNYJ01000005_gene5565	1.002e-108	357.0	COG1321@1|root,COG1321@2|Bacteria,2GKMC@201174|Actinobacteria,4DBBH@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix diphteria tox regulatory element	ideR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
TLS2_k127_2898765_2	33876.JNXY01000033_gene2161	2.131e-166	531.0	COG0579@1|root,COG0579@2|Bacteria,2GKFB@201174|Actinobacteria,4DB2N@85008|Micromonosporales	201174|Actinobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K15736	-	-	-	-	ko00000,ko01000	-	-	-	DAO
TLS2_k127_2898765_3	479432.Sros_3786	2.112e-136	451.0	COG2234@1|root,COG3227@1|root,COG4935@1|root,COG2234@2|Bacteria,COG3227@2|Bacteria,COG4935@2|Bacteria,2GIT0@201174|Actinobacteria,4EGRZ@85012|Streptosporangiales	201174|Actinobacteria	M	Thermolysin metallopeptidase, catalytic domain	-	-	3.4.11.24	ko:K19702	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	FTP,P_proprotein,Peptidase_M28,Peptidase_M4,Peptidase_M4_C
TLS2_k127_2909307_6	1464048.JNZS01000002_gene370	7.429e-117	383.0	COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4D9JD@85008|Micromonosporales	201174|Actinobacteria	K	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	glnR	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS2_k127_2909307_7	1121272.KB903250_gene3179	6.992e-104	347.0	COG0454@1|root,COG0456@2|Bacteria,2GM35@201174|Actinobacteria,4D8MC@85008|Micromonosporales	201174|Actinobacteria	K	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol	mshD	GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
TLS2_k127_2909307_14	644283.Micau_2521	3.671e-41	156.0	COG1765@1|root,COG1765@2|Bacteria,2IRWN@201174|Actinobacteria,4DE5H@85008|Micromonosporales	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_2909307_24	356851.JOAN01000030_gene5025	2.333e-11	70.0	2AEJG@1|root,314EZ@2|Bacteria,2HDUF@201174|Actinobacteria,4DKMD@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2909307_11	590998.Celf_0346	1.365e-62	221.0	COG1309@1|root,COG1309@2|Bacteria,2GM45@201174|Actinobacteria,4F2WK@85016|Cellulomonadaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
TLS2_k127_2909307_9	1122182.KB903825_gene348	2.922e-69	247.0	COG1073@1|root,COG1073@2|Bacteria,2IC0U@201174|Actinobacteria,4DDBT@85008|Micromonosporales	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Hydrolase_4
TLS2_k127_2909307_22	512565.AMIS_9810	1.393e-16	86.0	COG3012@1|root,COG3012@2|Bacteria,2GV65@201174|Actinobacteria	201174|Actinobacteria	O	SEC-C motif	-	-	-	-	-	-	-	-	-	-	-	-	SEC-C
TLS2_k127_2909307_4	1869.MB27_38745	2.015e-152	504.0	COG1674@1|root,COG1674@2|Bacteria,2GR9J@201174|Actinobacteria,4DAR9@85008|Micromonosporales	201174|Actinobacteria	D	DNA segregation ATPase FtsK SpoIIIE and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	FtsK_SpoIIIE
TLS2_k127_2909307_25	1121946.AUAX01000003_gene1755	3.951e-06	57.0	2ARV9@1|root,31H6Z@2|Bacteria,2IK2Y@201174|Actinobacteria,4DDSM@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2909307_5	1306406.ASHX01000002_gene5245	4.214e-151	487.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria	201174|Actinobacteria	M	Capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
TLS2_k127_2909307_8	500153.JOEK01000009_gene4819	2.48e-87	296.0	COG0566@1|root,COG0566@2|Bacteria,2GP9S@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS2_k127_2909307_16	994479.GL877878_gene1030	1.975e-40	153.0	2DM0Y@1|root,318KY@2|Bacteria,2IMIX@201174|Actinobacteria,4E63M@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF1992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1992
TLS2_k127_2909307_21	345341.KUTG_05229	1.968e-17	84.0	COG4118@1|root,COG4118@2|Bacteria,2HPA7@201174|Actinobacteria,4E7WH@85010|Pseudonocardiales	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS2_k127_2909307_10	350054.Mflv_3210	2.419e-63	220.0	COG1848@1|root,COG1848@2|Bacteria,2IQB5@201174|Actinobacteria,238VV@1762|Mycobacteriaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_2909307_15	134676.ACPL_2669	1.236e-40	151.0	COG3293@1|root,COG3293@2|Bacteria,2GN92@201174|Actinobacteria,4DBVU@85008|Micromonosporales	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
TLS2_k127_2909307_20	1394178.AWOO02000018_gene6582	1.779e-18	87.0	COG3293@1|root,COG3293@2|Bacteria,2GN92@201174|Actinobacteria,4EP2E@85012|Streptosporangiales	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
TLS2_k127_2909307_12	405948.SACE_2656	8.473e-58	204.0	COG3293@1|root,COG3293@2|Bacteria,2GN92@201174|Actinobacteria,4E496@85010|Pseudonocardiales	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
TLS2_k127_2909307_13	298655.KI912266_gene274	2.497e-57	203.0	COG2402@1|root,COG2402@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_2909307_18	479432.Sros_1366	2.267e-19	99.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS2_k127_2909307_17	369723.Strop_1983	4.374e-23	102.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria,4DM0R@85008|Micromonosporales	201174|Actinobacteria	L	Recombinase zinc beta ribbon domain	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_2909307_19	471853.Bcav_2556	4.988e-19	96.0	COG1680@1|root,COG1680@2|Bacteria,2GV1D@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_2909307_23	471853.Bcav_2556	2.566e-15	77.0	COG1680@1|root,COG1680@2|Bacteria,2GV1D@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_2909307_1	35754.JNYJ01000075_gene8662	0.0	1356.0	COG2909@1|root,COG2909@2|Bacteria,2GM1B@201174|Actinobacteria,4D8HV@85008|Micromonosporales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,GerE,Trans_reg_C
TLS2_k127_2909307_2	35754.JNYJ01000075_gene8661	4.275e-187	603.0	COG2333@1|root,COG2333@2|Bacteria,2H2F7@201174|Actinobacteria	201174|Actinobacteria	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2909307_3	35754.JNYJ01000075_gene8660	2.177e-169	543.0	2B7IV@1|root,320PF@2|Bacteria,2H4FX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2909307_0	35754.JNYJ01000075_gene8659	0.0	2450.0	2E80S@1|root,332EZ@2|Bacteria,2H37J@201174|Actinobacteria	201174|Actinobacteria	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2959184_0	1136417.AZWE01000019_gene4010	2.362e-274	873.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,2GKCX@201174|Actinobacteria,4DBR2@85008|Micromonosporales	201174|Actinobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
TLS2_k127_2959184_3	391037.Sare_3266	3.833e-133	436.0	COG1404@1|root,COG1404@2|Bacteria,2GNIX@201174|Actinobacteria,4DFUB@85008|Micromonosporales	201174|Actinobacteria	O	s53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS2_k127_2959184_9	369723.Strop_3039	1.857e-58	208.0	COG1595@1|root,COG1595@2|Bacteria,2GJUI@201174|Actinobacteria,4DF59@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
TLS2_k127_2959184_13	446462.Amir_0443	5.938e-12	73.0	2E27K@1|root,32XDT@2|Bacteria,2GRMM@201174|Actinobacteria,4E4VA@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2959184_1	66377.JOBH01000002_gene584	3.55e-190	612.0	COG1082@1|root,COG3185@1|root,COG1082@2|Bacteria,COG3185@2|Bacteria,2GNF0@201174|Actinobacteria	201174|Actinobacteria	E	4-hydroxyphenylpyruvate dioxygenase	-	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AP_endonuc_2,Glyoxalase,Glyoxalase_5
TLS2_k127_2959184_4	882083.SacmaDRAFT_4907	1.375e-127	417.0	COG1638@1|root,COG1638@2|Bacteria,2HTG5@201174|Actinobacteria,4E68R@85010|Pseudonocardiales	201174|Actinobacteria	G	TIGRFAM tripartite ATP-independent periplasmic transporter solute receptor, DctP family	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_2959184_2	882083.SacmaDRAFT_4906	1.525e-180	574.0	COG1593@1|root,COG1593@2|Bacteria,2GXEY@201174|Actinobacteria,4E2KD@85010|Pseudonocardiales	201174|Actinobacteria	G	TIGRFAM TRAP transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
TLS2_k127_2959184_12	1237500.ANBA01000007_gene2823	1.811e-35	146.0	COG3090@1|root,COG3090@2|Bacteria,2GR08@201174|Actinobacteria	201174|Actinobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_2959184_7	1137271.AZUM01000008_gene2028	4.983e-111	378.0	COG1063@1|root,COG1063@2|Bacteria,2I9U4@201174|Actinobacteria,4E8CD@85010|Pseudonocardiales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1,1.1.1.14	ko:K00001,ko:K00008	ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	M00014	R00623,R00754,R00875,R01896,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00085,RC00087,RC00088,RC00099,RC00102,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_2959184_5	1245475.ANAE01000210_gene1532	1.639e-124	408.0	COG1609@1|root,COG1609@2|Bacteria,2GMUU@201174|Actinobacteria,4EGAR@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529,ko:K05499	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_2959184_8	1121926.AXWO01000014_gene1809	6.463e-92	307.0	COG2409@1|root,COG2409@2|Bacteria,2IH0P@201174|Actinobacteria	201174|Actinobacteria	S	Drug exporters of the RND superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2959184_11	1121926.AXWO01000014_gene1810	1.287e-44	172.0	2E42V@1|root,32YZ9@2|Bacteria,2IG4T@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS2_k127_2959184_6	1121272.KB903249_gene1700	2.685e-120	403.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2GJYH@201174|Actinobacteria,4DBUI@85008|Micromonosporales	201174|Actinobacteria	M	Peptidase inhibitor I9	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,P_proprotein,Peptidase_S8
TLS2_k127_2959184_10	867903.ThesuDRAFT_01768	9.42e-45	173.0	COG2259@1|root,COG2259@2|Bacteria,1V4ER@1239|Firmicutes,24EBI@186801|Clostridia	186801|Clostridia	S	PFAM DoxX	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
TLS2_k127_2959185_2	219305.MCAG_04462	3.235e-41	152.0	2E39Y@1|root,32Y9G@2|Bacteria,2HUF3@201174|Actinobacteria,4DERS@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2959185_0	219305.MCAG_04463	8.092e-221	702.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4D9ZU@85008|Micromonosporales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_2959185_1	644283.Micau_1593	7.477e-88	297.0	COG0483@1|root,COG0483@2|Bacteria,2GJQE@201174|Actinobacteria,4DACR@85008|Micromonosporales	201174|Actinobacteria	G	Inositol monophosphatase	suhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043167,GO:0043169,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS2_k127_3038488_8	1118058.CAGY01000001_gene149	1.189e-12	70.0	2ASDQ@1|root,31HT6@2|Bacteria,2HMBW@201174|Actinobacteria,4D6R3@85005|Actinomycetales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3038488_3	390989.JOEG01000002_gene4111	2.772e-111	383.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4DBUA@85008|Micromonosporales	201174|Actinobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
TLS2_k127_3038488_5	1068980.ARVW01000001_gene2387	1.11e-92	329.0	COG0702@1|root,COG0702@2|Bacteria,2GJB8@201174|Actinobacteria,4E26P@85010|Pseudonocardiales	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
TLS2_k127_3038488_2	1150864.MILUP08_41791	1.614e-147	479.0	COG2124@1|root,COG2124@2|Bacteria,2I1XB@201174|Actinobacteria,4DA7S@85008|Micromonosporales	201174|Actinobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_3038488_4	644283.Micau_1679	2.305e-99	329.0	COG0132@1|root,COG0132@2|Bacteria,2GIZ2@201174|Actinobacteria,4DB72@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
TLS2_k127_3038488_1	1464048.JNZS01000021_gene2717	3.124e-158	508.0	COG0156@1|root,COG0156@2|Bacteria,2GISV@201174|Actinobacteria,4DARB@85008|Micromonosporales	201174|Actinobacteria	E	8-amino-7-oxononanoate synthase	bioF	-	2.3.1.47,6.2.1.14	ko:K00652,ko:K01906	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03209,R03210,R10124	RC00004,RC00014,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_3038488_0	644283.Micau_1677	1.014e-189	595.0	COG0502@1|root,COG0502@2|Bacteria,2GIUE@201174|Actinobacteria,4D8R0@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1589	BATS,Radical_SAM
TLS2_k127_3038488_6	1301098.PKB_5354	2.488e-41	168.0	COG0500@1|root,COG2226@2|Bacteria,1R51W@1224|Proteobacteria,1SFJF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_3038488_7	263358.VAB18032_12985	2.074e-17	95.0	2DQ34@1|root,334JF@2|Bacteria,2HUUG@201174|Actinobacteria,4DG16@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3047752_37	1122182.KB903836_gene4706	1.367e-78	279.0	COG2508@1|root,COG2508@2|Bacteria,2GKV3@201174|Actinobacteria,4DBJB@85008|Micromonosporales	201174|Actinobacteria	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
TLS2_k127_3047752_41	1122138.AQUZ01000011_gene4898	5.321e-53	196.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_3047752_8	1122138.AQUZ01000011_gene4900	1.135e-191	606.0	COG3486@1|root,COG3486@2|Bacteria,2GKTG@201174|Actinobacteria,4DN3P@85009|Propionibacteriales	201174|Actinobacteria	Q	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	1.14.13.195,1.14.13.196	ko:K10531	-	-	-	-	ko00000,ko01000	-	-	-	K_oxygenase
TLS2_k127_3047752_48	1150864.MILUP08_44034	7.024e-37	144.0	COG0662@1|root,COG0662@2|Bacteria,2IHNU@201174|Actinobacteria,4DF7V@85008|Micromonosporales	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_3047752_12	1122138.AQUZ01000011_gene4903	1.152e-182	582.0	COG0069@1|root,COG0069@2|Bacteria,2I8EI@201174|Actinobacteria	201174|Actinobacteria	E	Conserved region in glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
TLS2_k127_3047752_18	1463885.KL578565_gene3958	6.254e-152	486.0	COG0017@1|root,COG0017@2|Bacteria	2|Bacteria	J	Asparaginyl-tRNA synthetase	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2
TLS2_k127_3047752_10	1122138.AQUZ01000011_gene4907	4.474e-183	582.0	COG4865@1|root,COG4865@2|Bacteria,2I35W@201174|Actinobacteria	201174|Actinobacteria	E	Methylaspartate mutase E chain (MutE)	-	-	5.4.99.1	ko:K19268	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_asp_mut_E
TLS2_k127_3047752_40	749927.AMED_4749	1.019e-60	214.0	COG2185@1|root,COG2185@2|Bacteria,2IMIZ@201174|Actinobacteria,4E566@85010|Pseudonocardiales	201174|Actinobacteria	I	B12 binding domain	-	-	5.4.99.1	ko:K01846	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
TLS2_k127_3047752_6	1122138.AQUZ01000011_gene4920	6.841e-214	674.0	28MD1@1|root,2ZAQX@2|Bacteria,2I9AP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3047752_42	1122138.AQUZ01000011_gene4919	3.031e-48	176.0	COG0662@1|root,COG0662@2|Bacteria,2IQFZ@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_3047752_3	1122138.AQUZ01000011_gene4918	6.071e-255	796.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4DNQ0@85009|Propionibacteriales	201174|Actinobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	-	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Cupin_2,tRNA-synt_1g
TLS2_k127_3047752_25	1122138.AQUZ01000011_gene4917	3.8e-119	393.0	COG0665@1|root,COG0665@2|Bacteria	2|Bacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAD_binding_2,NAD_binding_8
TLS2_k127_3047752_7	1122138.AQUZ01000011_gene4915	1.598e-202	638.0	COG0458@1|root,COG0458@2|Bacteria,2I3TE@201174|Actinobacteria	201174|Actinobacteria	EF	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
TLS2_k127_3047752_1	1122138.AQUZ01000011_gene4914	7.427e-301	930.0	COG0747@1|root,COG0747@2|Bacteria,2GZTR@201174|Actinobacteria,4DQQI@85009|Propionibacteriales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_3047752_9	1122138.AQUZ01000011_gene4911	9.898e-189	599.0	COG2308@1|root,COG2308@2|Bacteria,2GP4E@201174|Actinobacteria	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3047752_11	1122138.AQUZ01000011_gene4913	1.148e-182	585.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_3047752_20	1122138.AQUZ01000011_gene4912	1.815e-139	461.0	COG0477@1|root,COG2814@2|Bacteria,2GJU2@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS2_k127_3047752_14	1122138.AQUZ01000011_gene4905	1.922e-170	545.0	COG0531@1|root,COG0531@2|Bacteria,2IAK1@201174|Actinobacteria,4DU4R@85009|Propionibacteriales	201174|Actinobacteria	E	Amino acid permease	-	-	-	ko:K16263	-	-	-	-	ko00000,ko02000	2.A.3.13	-	-	AA_permease_2
TLS2_k127_3047752_39	1122138.AQUZ01000011_gene4902	2.23e-71	250.0	COG3629@1|root,COG3629@2|Bacteria,2IC17@201174|Actinobacteria	201174|Actinobacteria	T	DNA-binding transcriptional activator of the SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
TLS2_k127_3047752_17	1122138.AQUZ01000011_gene4901	1.278e-153	496.0	COG0151@1|root,COG0151@2|Bacteria,2GXFQ@201174|Actinobacteria	201174|Actinobacteria	F	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
TLS2_k127_3047752_13	1122138.AQUZ01000011_gene4900	2.333e-173	554.0	COG3486@1|root,COG3486@2|Bacteria,2GKTG@201174|Actinobacteria,4DN3P@85009|Propionibacteriales	201174|Actinobacteria	Q	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	1.14.13.195,1.14.13.196	ko:K10531	-	-	-	-	ko00000,ko01000	-	-	-	K_oxygenase
TLS2_k127_3047752_50	1120934.KB894407_gene5246	6.221e-35	139.0	COG0590@1|root,COG0590@2|Bacteria,2IHXE@201174|Actinobacteria,4E6V7@85010|Pseudonocardiales	201174|Actinobacteria	FJ	tRNA wobble adenosine to inosine editing	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3047752_26	208439.AJAP_23535	4.611e-113	372.0	COG1834@1|root,COG1834@2|Bacteria,2GNTN@201174|Actinobacteria,4DYJJ@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM amidinotransferase	-	GO:0003674,GO:0003824,GO:0016403,GO:0016787,GO:0016810,GO:0016813	-	-	-	-	-	-	-	-	-	-	Amidinotransf
TLS2_k127_3047752_19	208439.AJAP_19630	5.643e-150	485.0	COG0475@1|root,COG0475@2|Bacteria,2GIRC@201174|Actinobacteria,4E22F@85010|Pseudonocardiales	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS2_k127_3047752_24	1463936.JOJI01000006_gene4181	1.021e-121	398.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_3047752_45	1179773.BN6_26700	2.145e-42	169.0	COG3801@1|root,COG3801@2|Bacteria,2IR6E@201174|Actinobacteria,4E5K3@85010|Pseudonocardiales	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
TLS2_k127_3047752_46	1122611.KB903940_gene1804	7.524e-42	161.0	COG1725@1|root,COG1725@2|Bacteria,2IQEW@201174|Actinobacteria,4EJGX@85012|Streptosporangiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	GntR
TLS2_k127_3047752_22	1464048.JNZS01000007_gene4539	5.11e-127	410.0	COG1878@1|root,COG1878@2|Bacteria,2GNFV@201174|Actinobacteria,4DE30@85008|Micromonosporales	201174|Actinobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_3047752_4	1464048.JNZS01000007_gene4538	1.551e-225	717.0	COG0028@1|root,COG0028@2|Bacteria,2GKGX@201174|Actinobacteria,4DH2H@85008|Micromonosporales	201174|Actinobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_3047752_23	356851.JOAN01000028_gene586	2.63e-123	401.0	COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria,4DC4S@85008|Micromonosporales	201174|Actinobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TLS2_k127_3047752_35	35754.JNYJ01000022_gene8188	2.317e-98	332.0	COG0697@1|root,COG0697@2|Bacteria,2GMPB@201174|Actinobacteria,4DC89@85008|Micromonosporales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	ko:K15269	-	-	-	-	ko00000,ko02000	2.A.7.3.3	-	-	EamA
TLS2_k127_3047752_16	1121946.AUAX01000012_gene6490	1.168e-163	534.0	COG0747@1|root,COG0747@2|Bacteria,2GJXH@201174|Actinobacteria,4DAV1@85008|Micromonosporales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_3047752_49	1120949.KB903308_gene1282	3.786e-35	138.0	COG1314@1|root,COG1314@2|Bacteria,2GR31@201174|Actinobacteria,4DF0E@85008|Micromonosporales	201174|Actinobacteria	U	preprotein translocase	secG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
TLS2_k127_3047752_33	1121946.AUAX01000012_gene6493	1.343e-101	339.0	COG0363@1|root,COG0363@2|Bacteria,2GMQ2@201174|Actinobacteria,4DA24@85008|Micromonosporales	201174|Actinobacteria	G	6-phosphogluconolactonase	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:1901135,GO:1901360,GO:1901564	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
TLS2_k127_3047752_27	644283.Micau_4331	5.098e-113	376.0	COG3429@1|root,COG3429@2|Bacteria,2GJ1H@201174|Actinobacteria,4DA86@85008|Micromonosporales	201174|Actinobacteria	G	Glucose-6-phosphate dehydrogenase subunit	opcA	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
TLS2_k127_3047752_2	219305.MCAG_01094	1.383e-272	850.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4D9N1@85008|Micromonosporales	201174|Actinobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TLS2_k127_3047752_5	1150864.MILUP08_44956	6.675e-218	689.0	COG0166@1|root,COG0166@2|Bacteria,2I3YW@201174|Actinobacteria,4D8VI@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the GPI family	-	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
TLS2_k127_3047752_15	263358.VAB18032_25975	1.475e-166	535.0	COG0176@1|root,COG0176@2|Bacteria,2GMF9@201174|Actinobacteria,4D9UT@85008|Micromonosporales	201174|Actinobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TLS2_k127_3047752_0	263358.VAB18032_25970	0.0	1094.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4D8Y4@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the transketolase family	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TLS2_k127_3047752_32	1464048.JNZS01000029_gene1787	4.894e-102	366.0	COG0109@1|root,COG0109@2|Bacteria,2GJMY@201174|Actinobacteria,4DANA@85008|Micromonosporales	201174|Actinobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
TLS2_k127_3047752_44	391037.Sare_3314	1.059e-43	162.0	2ER41@1|root,33IPK@2|Bacteria,2IKQ6@201174|Actinobacteria,4DE2S@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3047752_28	1464048.JNZS01000029_gene1785	5.069e-109	362.0	COG0189@1|root,COG0189@2|Bacteria,2HI2Z@201174|Actinobacteria,4DBDA@85008|Micromonosporales	201174|Actinobacteria	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	GSH-S_ATP
TLS2_k127_3047752_38	356851.JOAN01000018_gene5666	9.693e-73	258.0	COG2852@1|root,COG2852@2|Bacteria,2IPYY@201174|Actinobacteria,4DER5@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
TLS2_k127_3047752_34	1463926.JOCA01000008_gene2344	2.006e-98	332.0	COG1414@1|root,COG1414@2|Bacteria,2GNHA@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	pcaR	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
TLS2_k127_3047752_47	1089544.KB912942_gene4458	5.068e-40	159.0	COG0599@1|root,COG0599@2|Bacteria,2GITB@201174|Actinobacteria,4E43F@85010|Pseudonocardiales	201174|Actinobacteria	S	Carboxymuconolactone decarboxylase family	pcaC	-	3.1.1.24,4.1.1.44	ko:K01607,ko:K14727	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991,R03470	RC00825,RC00938	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4,CMD
TLS2_k127_3047752_31	35754.JNYJ01000012_gene997	8.755e-106	361.0	COG0015@1|root,COG0015@2|Bacteria,2GM71@201174|Actinobacteria,4DA3U@85008|Micromonosporales	201174|Actinobacteria	F	Adenylosuccinate lyase C-terminus	pcaB	-	5.5.1.2	ko:K01857	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03307	RC00902	ko00000,ko00001,ko01000	-	-	-	ADSL_C,Lyase_1
TLS2_k127_3047752_43	1206739.BAGJ01000270_gene2548	2.256e-47	177.0	COG3485@1|root,COG3485@2|Bacteria,2GZGT@201174|Actinobacteria,4FY92@85025|Nocardiaceae	201174|Actinobacteria	Q	protocatechuate 3,4-dioxygenase	pcaG	-	1.13.11.3	ko:K00448	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
TLS2_k127_3047752_29	103733.JNYO01000020_gene1979	4.005e-106	357.0	COG3485@1|root,COG3485@2|Bacteria,2GMGM@201174|Actinobacteria,4DZ5N@85010|Pseudonocardiales	201174|Actinobacteria	Q	Protocatechuate 3,4-dioxygenase, beta	pcaH	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,PCDO_beta_N
TLS2_k127_3047752_30	1246995.AFR_19285	7.352e-106	364.0	COG2057@1|root,COG2057@2|Bacteria,2GMA1@201174|Actinobacteria,4DB71@85008|Micromonosporales	201174|Actinobacteria	I	Coenzyme A transferase	catJ	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS2_k127_3047752_21	1068980.ARVW01000001_gene808	1.413e-135	436.0	COG1788@1|root,COG1788@2|Bacteria,2I9F6@201174|Actinobacteria,4DXHC@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	gctA	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS2_k127_3047752_36	1869.MB27_42470	4.66e-91	310.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria,4DDFQ@85008|Micromonosporales	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TLS2_k127_3047851_1	644283.Micau_5305	2.645e-94	315.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria,4DC0K@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS2_k127_3047851_6	1068980.ARVW01000001_gene4167	4.731e-09	65.0	COG1737@1|root,COG1737@2|Bacteria,2GMN2@201174|Actinobacteria,4DY1A@85010|Pseudonocardiales	201174|Actinobacteria	K	Helix-turn-helix domain, rpiR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
TLS2_k127_3047851_5	1236902.ANAS01000009_gene2695	1.66e-21	101.0	COG2358@1|root,COG2358@2|Bacteria,2GKQJ@201174|Actinobacteria	201174|Actinobacteria	S	TRAP transporter solute receptor TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
TLS2_k127_3047851_3	1246448.ANAZ01000004_gene4715	5.415e-62	227.0	COG2358@1|root,COG2358@2|Bacteria,2GKQJ@201174|Actinobacteria	201174|Actinobacteria	S	TRAP transporter solute receptor TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
TLS2_k127_3047851_4	1236902.ANAS01000009_gene2694	7.814e-31	129.0	COG4729@1|root,COG4729@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF1850)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1850
TLS2_k127_3047851_0	443218.AS9A_1705	1.845e-206	668.0	COG4666@1|root,COG4666@2|Bacteria,2H91Y@201174|Actinobacteria,236PA@1762|Mycobacteriaceae	201174|Actinobacteria	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_3047851_2	512565.AMIS_73390	2.705e-67	231.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4D9MD@85008|Micromonosporales	201174|Actinobacteria	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_3090736_1	1132441.KI519454_gene569	3.817e-159	521.0	28H5N@1|root,2Z7I8@2|Bacteria,2IC8E@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3090736_0	1298863.AUEP01000020_gene3616	5.468e-219	742.0	COG0845@1|root,COG1579@1|root,COG0845@2|Bacteria,COG1579@2|Bacteria,2H3CU@201174|Actinobacteria,4DT0M@85009|Propionibacteriales	201174|Actinobacteria	M	Zn-ribbon protein possibly nucleic acid-binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3090736_3	1298863.AUEP01000020_gene3615	1.403e-122	432.0	COG0222@1|root,COG0222@2|Bacteria,2IAAR@201174|Actinobacteria,4DU9S@85009|Propionibacteriales	201174|Actinobacteria	J	ribosome binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3090736_2	1298863.AUEP01000020_gene3614	5.528e-133	445.0	COG0419@1|root,COG0419@2|Bacteria,2I9QM@201174|Actinobacteria,4DT54@85009|Propionibacteriales	201174|Actinobacteria	L	ATPase involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3090736_4	1122138.AQUZ01000004_gene1020	2.519e-113	385.0	COG2197@1|root,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria,4DTSR@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_3090736_5	1121946.AUAX01000026_gene6226	1.915e-95	324.0	COG2890@1|root,COG2890@2|Bacteria,2I3R2@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_3090736_7	390989.JOEG01000022_gene2329	4.015e-10	66.0	2DMRR@1|root,32T8I@2|Bacteria,2IKQU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3090736_6	1279017.AQYJ01000026_gene246	3.825e-71	253.0	COG2050@1|root,COG2050@2|Bacteria,1RF3N@1224|Proteobacteria,1S82J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_3112555_2	219305.MCAG_02333	7.57e-89	305.0	COG1277@1|root,COG1277@2|Bacteria,2GNQV@201174|Actinobacteria,4DB3R@85008|Micromonosporales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS2_k127_3112555_5	356851.JOAN01000015_gene2610	8.334e-28	116.0	2CUM0@1|root,32SVJ@2|Bacteria,2IQG7@201174|Actinobacteria,4DF8J@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3263)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3263
TLS2_k127_3112555_1	1123320.KB889714_gene8119	8.354e-107	354.0	COG0111@1|root,COG0111@2|Bacteria,2GP09@201174|Actinobacteria	201174|Actinobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase	pdxB	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_3112555_4	1394178.AWOO02000004_gene2395	1.015e-53	194.0	COG1670@1|root,COG1670@2|Bacteria,2IJZH@201174|Actinobacteria	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_3112555_0	1464048.JNZS01000002_gene418	2.147e-290	908.0	COG1222@1|root,COG1222@2|Bacteria,2GJNW@201174|Actinobacteria,4DBCQ@85008|Micromonosporales	201174|Actinobacteria	O	Belongs to the AAA ATPase family	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_N
TLS2_k127_3112555_6	1133849.O3I_009785	6.798e-11	73.0	2FJMH@1|root,34BAU@2|Bacteria,2GW2I@201174|Actinobacteria,4FZ20@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3112555_3	749414.SBI_01051	1.821e-60	220.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator, SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,NB-ARC,TPR_10,TPR_12,TPR_7,TPR_8,Trans_reg_C
TLS2_k127_3390316_0	356851.JOAN01000007_gene4047	9.406e-158	501.0	COG0276@1|root,COG0276@2|Bacteria,2GJTQ@201174|Actinobacteria,4D92F@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
TLS2_k127_3390316_1	369723.Strop_3024	1.458e-128	414.0	COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria,4D93E@85008|Micromonosporales	201174|Actinobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	inhA	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030312,GO:0030497,GO:0031406,GO:0032787,GO:0033293,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208,ko:K11611	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_339925_2	644283.Micau_4941	2.028e-154	490.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4D919@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	amnC	-	1.2.1.32,1.2.1.85	ko:K10217	ko00362,ko00380,ko00622,ko01100,ko01120,ko01220,map00362,map00380,map00622,map01100,map01120,map01220	M00038,M00569	R02762,R03889,R05353	RC00218,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_339925_4	28444.JODQ01000012_gene3271	5.105e-119	392.0	COG3971@1|root,COG3971@2|Bacteria,2GPBI@201174|Actinobacteria,4EGTR@85012|Streptosporangiales	201174|Actinobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	4.2.1.80	ko:K02554	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R02601,R04781	RC00750,RC01213	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
TLS2_k127_339925_7	263358.VAB18032_28741	1.405e-84	297.0	COG3971@1|root,COG3971@2|Bacteria,2GM4Z@201174|Actinobacteria,4DAR5@85008|Micromonosporales	201174|Actinobacteria	Q	decarboxylase	-	-	4.1.1.77	ko:K01617	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R02602,R05374	RC00751,RC02672	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
TLS2_k127_339925_6	644283.Micau_4935	1.802e-92	306.0	COG0662@1|root,COG0662@2|Bacteria,2HC8M@201174|Actinobacteria,4DD69@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate	nbaC	-	1.13.11.6	ko:K00452	ko00380,ko01100,map00380,map01100	M00038	R02665	RC00387	ko00000,ko00001,ko00002,ko01000	-	-	-	3-HAO
TLS2_k127_339925_1	28444.JODQ01000012_gene3265	3.557e-186	586.0	COG2159@1|root,COG2159@2|Bacteria,2HEB4@201174|Actinobacteria,4EFXB@85012|Streptosporangiales	201174|Actinobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
TLS2_k127_339925_8	196162.Noca_2682	3.893e-74	253.0	COG0346@1|root,COG0346@2|Bacteria,2HKRN@201174|Actinobacteria,4DPT9@85009|Propionibacteriales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_339925_5	408672.NBCG_02725	6.285e-93	313.0	29ZNQ@1|root,30MP9@2|Bacteria,2IJUR@201174|Actinobacteria,4DUE8@85009|Propionibacteriales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS2_k127_339925_9	1380393.JHVP01000004_gene750	2.232e-67	255.0	COG1454@1|root,COG1454@2|Bacteria,2I2FD@201174|Actinobacteria,4ETWT@85013|Frankiales	201174|Actinobacteria	C	Iron-containing alcohol dehydrogenase	-	-	1.3.1.32	ko:K00217	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	-	R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224	RC00107,RC01335,RC01689,RC02442	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
TLS2_k127_339925_10	1380356.JNIK01000017_gene3019	1.942e-61	226.0	COG2197@1|root,COG2197@2|Bacteria,2IATK@201174|Actinobacteria	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_339925_3	391037.Sare_3895	6.178e-150	493.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4DAHP@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the amidase family	amiB	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS2_k127_339925_12	219305.MCAG_01602	1.47e-07	58.0	2EGNC@1|root,33AEH@2|Bacteria,2GT43@201174|Actinobacteria,4DFWI@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_339925_11	35754.JNYJ01000065_gene5697	3.159e-43	164.0	COG1512@1|root,COG1512@2|Bacteria,2IRMT@201174|Actinobacteria,4DE5Z@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF5130)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF5130
TLS2_k127_339925_0	324602.Caur_1909	4.904e-214	702.0	COG1404@1|root,COG1404@2|Bacteria,2G5S0@200795|Chloroflexi,376YT@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8
TLS2_k127_3472360_30	219305.MCAG_00423	2.167e-56	198.0	COG0640@1|root,COG0640@2|Bacteria,2IM1K@201174|Actinobacteria,4DE6N@85008|Micromonosporales	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS2_k127_3472360_23	469383.Cwoe_1479	1.678e-91	305.0	COG3832@1|root,COG3832@2|Bacteria,2IE7C@201174|Actinobacteria,4CSTG@84995|Rubrobacteria	84995|Rubrobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_3472360_6	1246995.AFR_38990	8.159e-240	751.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DBSQ@85008|Micromonosporales	201174|Actinobacteria	IQ	Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_3472360_29	479432.Sros_2465	1.933e-58	211.0	COG1576@1|root,COG1576@2|Bacteria,2IG2P@201174|Actinobacteria,4EPHV@85012|Streptosporangiales	201174|Actinobacteria	J	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS2_k127_3472360_33	416591.Tlet_0025	6.466e-25	119.0	COG0329@1|root,COG0329@2|Bacteria,2GC68@200918|Thermotogae	200918|Thermotogae	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_3472360_7	479435.Kfla_3209	2.547e-235	751.0	COG4447@1|root,COG4447@2|Bacteria,2I4PF@201174|Actinobacteria	201174|Actinobacteria	E	Zinc metalloprotease (Elastase)	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
TLS2_k127_3472360_10	1125971.ASJB01000042_gene3597	3.552e-176	567.0	COG0154@1|root,COG0154@2|Bacteria,2GSDB@201174|Actinobacteria,4E085@85010|Pseudonocardiales	201174|Actinobacteria	J	Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS2_k127_3472360_15	219305.MCAG_01340	2e-118	389.0	COG1619@1|root,COG1619@2|Bacteria,2HPR8@201174|Actinobacteria,4D9C0@85008|Micromonosporales	201174|Actinobacteria	V	peptidase U61 LD-carboxypeptidase A	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
TLS2_k127_3472360_32	251221.35211118	2.664e-43	176.0	COG0388@1|root,COG0388@2|Bacteria,1FZZG@1117|Cyanobacteria	1117|Cyanobacteria	S	Alternative locus ID	-	-	-	-	-	-	-	-	-	-	-	-	DUF3326
TLS2_k127_3472360_27	67352.JODS01000017_gene2892	4.481e-83	289.0	COG1595@1|root,COG1595@2|Bacteria,2I4SD@201174|Actinobacteria	201174|Actinobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3472360_20	369723.Strop_3336	7.725e-99	328.0	COG0518@1|root,COG0518@2|Bacteria,2GNA6@201174|Actinobacteria,4D8JU@85008|Micromonosporales	201174|Actinobacteria	F	glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase
TLS2_k127_3472360_1	1869.MB27_16350	0.0	1193.0	COG1391@1|root,COG1391@2|Bacteria,2GJ91@201174|Actinobacteria,4D8RI@85008|Micromonosporales	201174|Actinobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
TLS2_k127_3472360_3	909613.UO65_0807	0.0	1149.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4E8XQ@85010|Pseudonocardiales	201174|Actinobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
TLS2_k127_3472360_0	1242864.D187_002864	0.0	2113.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1QK4F@1224|Proteobacteria	1224|Proteobacteria	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Bac_luciferase,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
TLS2_k127_3472360_2	1144275.COCOR_04204	0.0	1163.0	COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1MU6G@1224|Proteobacteria,43C6Z@68525|delta/epsilon subdivisions,2X8MX@28221|Deltaproteobacteria,2YYNS@29|Myxococcales	68525|delta/epsilon subdivisions	IQ	Luciferase-like monooxygenase	-	-	-	ko:K18660	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Bac_luciferase,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,Thioesterase,ketoacyl-synt
TLS2_k127_3472360_28	298653.Franean1_6895	1.405e-62	228.0	29JDG@1|root,306AZ@2|Bacteria,2HQW1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NNMT_PNMT_TEMT
TLS2_k127_3472360_9	512565.AMIS_14660	2.221e-184	594.0	28J9Z@1|root,2Z94V@2|Bacteria,2IA0V@201174|Actinobacteria,4D8TE@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3472360_14	219305.MCAG_05610	6.576e-121	394.0	COG0455@1|root,COG0455@2|Bacteria,2GP7U@201174|Actinobacteria,4DB3T@85008|Micromonosporales	201174|Actinobacteria	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
TLS2_k127_3472360_16	33876.JNXY01000041_gene6453	3.913e-113	377.0	28MZF@1|root,2ZB65@2|Bacteria,2I4S4@201174|Actinobacteria,4D8Q4@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3472360_26	33876.JNXY01000041_gene6455	1.31e-83	287.0	2BX5M@1|root,32RDI@2|Bacteria,2I5QA@201174|Actinobacteria,4DCWD@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3472360_24	33876.JNXY01000041_gene6456	1.528e-89	306.0	2C6RY@1|root,30GV3@2|Bacteria,2I8Y4@201174|Actinobacteria,4DDEH@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3472360_19	1136417.AZWE01000014_gene1712	6.47e-100	335.0	COG0665@1|root,COG0665@2|Bacteria,2GN2M@201174|Actinobacteria,4DCRI@85008|Micromonosporales	201174|Actinobacteria	E	FAD dependent oxidoreductase	aao	GO:0003674,GO:0003824,GO:0003884,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046416,GO:0055114,GO:0071704,GO:1901564,GO:1901605	1.4.3.3	ko:K00273	ko00260,ko00311,ko00330,ko00472,ko01100,ko01130,ko04146,map00260,map00311,map00330,map00472,map01100,map01130,map04146	-	R00366,R02457,R02894,R02923,R04221,R07400	RC00006,RC00018,RC00135	ko00000,ko00001,ko01000	-	-	-	DAO
TLS2_k127_3472360_4	644283.Micau_4621	2.651e-274	849.0	COG0174@1|root,COG0174@2|Bacteria,2GMN1@201174|Actinobacteria,4D8PH@85008|Micromonosporales	201174|Actinobacteria	E	glutamine synthetase	glnA	GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS2_k127_3472360_21	1136417.AZWE01000002_gene3501	5.761e-94	313.0	2AUFS@1|root,31K3Y@2|Bacteria,2GIXC@201174|Actinobacteria,4D9DF@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4191)	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF4191
TLS2_k127_3472360_12	1150864.MILUP08_45266	2.566e-175	557.0	COG0320@1|root,COG0320@2|Bacteria,2GKD4@201174|Actinobacteria,4D8DS@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
TLS2_k127_3472360_8	219305.MCAG_01328	3.001e-205	647.0	COG0017@1|root,COG0017@2|Bacteria,2I2KQ@201174|Actinobacteria,4D8VG@85008|Micromonosporales	201174|Actinobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12,6.1.1.23	ko:K01876,ko:K09759	ko00970,map00970	M00359,M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_2,tRNA_anti-codon
TLS2_k127_3472360_25	219305.MCAG_01326	1.731e-87	298.0	COG0321@1|root,COG0321@2|Bacteria,2GJIX@201174|Actinobacteria,4DADI@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TLS2_k127_3472360_31	1068978.AMETH_1073	8.761e-48	177.0	2A9XB@1|root,30Z5E@2|Bacteria,2IFFN@201174|Actinobacteria,4E3TX@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3472360_22	644283.Micau_4050	1.151e-92	318.0	COG2141@1|root,COG2141@2|Bacteria,2GKCU@201174|Actinobacteria,4DA0S@85008|Micromonosporales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_3472360_18	356851.JOAN01000010_gene4554	4.384e-108	359.0	COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria,4DA5A@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF1731)	-	GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0030312,GO:0031073,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046906,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
TLS2_k127_3472360_34	33876.JNXY01000029_gene2819	1.706e-18	97.0	2BZ7I@1|root,32R4F@2|Bacteria,2IF95@201174|Actinobacteria,4DHFB@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3472360_35	1146883.BLASA_4079	4.962e-07	63.0	COG1520@1|root,COG1520@2|Bacteria,2HTKU@201174|Actinobacteria,4ETFX@85013|Frankiales	201174|Actinobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_3472360_17	1869.MB27_19825	7.364e-110	366.0	COG2380@1|root,COG2380@2|Bacteria,2I8F9@201174|Actinobacteria,4DA01@85008|Micromonosporales	201174|Actinobacteria	S	COGs COG2380 conserved	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3472360_5	263358.VAB18032_12895	6.086e-252	808.0	COG0419@1|root,COG0419@2|Bacteria,2GKYR@201174|Actinobacteria,4DA3T@85008|Micromonosporales	201174|Actinobacteria	L	Putative exonuclease SbcCD, C subunit	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SbcCD_C
TLS2_k127_3472360_13	356851.JOAN01000008_gene3001	6.296e-161	523.0	COG0420@1|root,COG0420@2|Bacteria,2GK9R@201174|Actinobacteria,4D95R@85008|Micromonosporales	201174|Actinobacteria	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
TLS2_k127_3472360_11	356851.JOAN01000008_gene3000	4.869e-176	555.0	COG0433@1|root,COG0433@2|Bacteria,2I0H5@201174|Actinobacteria,4D9TP@85008|Micromonosporales	201174|Actinobacteria	S	COG0433 Predicted ATPase	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_3520539_35	1246995.AFR_19305	1.382e-86	297.0	COG0600@1|root,COG0600@2|Bacteria,2GP2J@201174|Actinobacteria,4DD7Y@85008|Micromonosporales	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system, permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_3520539_31	1120949.KB903336_gene9667	1.599e-95	335.0	COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria,4DIAE@85008|Micromonosporales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_3520539_21	543632.JOJL01000029_gene3754	7.197e-120	391.0	COG1116@1|root,COG1116@2|Bacteria,2GM73@201174|Actinobacteria,4D8MK@85008|Micromonosporales	201174|Actinobacteria	P	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TLS2_k127_3520539_11	1068978.AMETH_4192	2.598e-202	641.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4DZDT@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	xylC	-	1.2.1.28	ko:K00141	ko00622,ko00623,ko00627,ko01100,ko01120,ko01220,map00622,map00623,map00627,map01100,map01120,map01220	M00537,M00538	R01293,R01419,R05289,R05663,R05664,R07667	RC00075	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_3520539_16	263358.VAB18032_19700	9.127e-158	507.0	COG0654@1|root,COG0654@2|Bacteria,2GM48@201174|Actinobacteria,4DA82@85008|Micromonosporales	201174|Actinobacteria	CH	FAD binding domain	pobA	-	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
TLS2_k127_3520539_12	1120949.KB903294_gene3609	3.306e-192	606.0	COG0620@1|root,COG0620@2|Bacteria,2I9RI@201174|Actinobacteria,4DHUA@85008|Micromonosporales	201174|Actinobacteria	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
TLS2_k127_3520539_57	1121272.KB903289_gene4154	3.279e-36	151.0	2E9QH@1|root,333WV@2|Bacteria,2IC0C@201174|Actinobacteria,4DFVJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3520539_65	1333523.L593_04100	7.085e-06	55.0	COG3291@1|root,arCOG02546@2157|Archaea	2157|Archaea	M	protein contain chitin-binding domain type 3	-	-	3.2.1.14,3.2.1.202	ko:K01183,ko:K21606	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	CBM5,GH18	-	CARDB,Glyco_hydro_18,Malectin,PKD
TLS2_k127_3520539_33	644283.Micau_4320	4.685e-93	328.0	COG1612@1|root,COG1612@2|Bacteria,2GJQX@201174|Actinobacteria,4DA27@85008|Micromonosporales	201174|Actinobacteria	O	cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
TLS2_k127_3520539_27	219305.MCAG_01086	8.042e-100	336.0	COG2345@1|root,COG2345@2|Bacteria,2GN8W@201174|Actinobacteria,4D9KQ@85008|Micromonosporales	201174|Actinobacteria	K	transcriptional regulator	sufR	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20,HTH_24,HTH_5,MarR_2
TLS2_k127_3520539_4	219305.MCAG_01085	9.857e-289	892.0	COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria,4D8I1@85008|Micromonosporales	201174|Actinobacteria	O	assembly protein sufB	sufB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TLS2_k127_3520539_15	219305.MCAG_01084	3.087e-165	530.0	COG0719@1|root,COG0719@2|Bacteria,2GJNV@201174|Actinobacteria,4DB11@85008|Micromonosporales	201174|Actinobacteria	O	FeS assembly protein SufD	sufD	GO:0008150,GO:0009605,GO:0009607,GO:0040007,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
TLS2_k127_3520539_54	391037.Sare_3308	3.905e-50	179.0	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,4DEJP@85008|Micromonosporales	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	hcaC	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
TLS2_k127_3520539_17	35754.JNYJ01000012_gene1007	1.503e-143	459.0	COG0396@1|root,COG0396@2|Bacteria,2GKB7@201174|Actinobacteria,4DAS1@85008|Micromonosporales	201174|Actinobacteria	O	FeS assembly ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
TLS2_k127_3520539_13	298655.KI912267_gene7008	4.424e-178	569.0	COG0520@1|root,COG0520@2|Bacteria,2GIVK@201174|Actinobacteria,4ERTT@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
TLS2_k127_3520539_44	103733.JNYO01000026_gene8808	6.281e-63	219.0	COG0822@1|root,COG0822@2|Bacteria,2IHY9@201174|Actinobacteria,4E2WE@85010|Pseudonocardiales	201174|Actinobacteria	C	SUF system FeS assembly protein, NifU family	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS2_k127_3520539_49	134676.ACPL_1877	1.967e-56	207.0	COG2151@1|root,COG2151@2|Bacteria,2IKUH@201174|Actinobacteria,4DE2N@85008|Micromonosporales	201174|Actinobacteria	S	Pfam:DUF59	yitW	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
TLS2_k127_3520539_20	1464048.JNZS01000009_gene5854	2.147e-125	418.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,2GJYH@201174|Actinobacteria,4DADU@85008|Micromonosporales	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,P_proprotein,Peptidase_S8
TLS2_k127_3520539_18	35754.JNYJ01000042_gene1354	1.136e-137	448.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4DA3D@85008|Micromonosporales	201174|Actinobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
TLS2_k127_3520539_34	1122182.KB903833_gene5501	1.222e-86	294.0	COG4325@1|root,COG4325@2|Bacteria,2GM70@201174|Actinobacteria,4DBKB@85008|Micromonosporales	201174|Actinobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3520539_38	390989.JOEG01000012_gene3449	1.274e-81	287.0	COG4912@1|root,COG4912@2|Bacteria,2GNQD@201174|Actinobacteria,4DCZ3@85008|Micromonosporales	201174|Actinobacteria	L	DNA alkylation repair enzyme	alkD	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
TLS2_k127_3520539_45	1464048.JNZS01000029_gene1774	9.205e-63	223.0	COG1503@1|root,COG1503@2|Bacteria,2IFQH@201174|Actinobacteria,4DCQ7@85008|Micromonosporales	201174|Actinobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3520539_5	35754.JNYJ01000012_gene1016	9.297e-278	861.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria,4DA2V@85008|Micromonosporales	201174|Actinobacteria	S	ABC transporter	ybiT	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn,DLIC
TLS2_k127_3520539_60	1121946.AUAX01000008_gene7243	7.675e-33	128.0	2E4I7@1|root,32ZDA@2|Bacteria,2IQBB@201174|Actinobacteria,4DF3B@85008|Micromonosporales	201174|Actinobacteria	S	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3520539_28	644283.Micau_4303	8.909e-100	331.0	COG1024@1|root,COG1024@2|Bacteria,2GKC4@201174|Actinobacteria,4D8DY@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_3520539_3	263358.VAB18032_25865	9.937e-309	955.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4D8JC@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter related	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_3520539_25	263358.VAB18032_25855	2.112e-111	364.0	COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria,4D9WM@85008|Micromonosporales	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_3520539_48	391037.Sare_3985	8.555e-60	218.0	COG3764@1|root,COG3764@2|Bacteria,2I91T@201174|Actinobacteria,4DCS8@85008|Micromonosporales	201174|Actinobacteria	M	peptidase C60 sortase A and B	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
TLS2_k127_3520539_62	263358.VAB18032_29371	1.742e-24	112.0	297KM@1|root,2ZUTQ@2|Bacteria,2IPIM@201174|Actinobacteria,4DEHJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3520539_30	1150864.MILUP08_44925	5.593e-96	318.0	COG1309@1|root,COG1309@2|Bacteria,2GZ1Y@201174|Actinobacteria,4D9EG@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	acnR	GO:0000287,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043167,GO:0043169,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K21962	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
TLS2_k127_3520539_58	216594.MMAR_2245	1.932e-35	141.0	2C2H6@1|root,337ZN@2|Bacteria,2GS3J@201174|Actinobacteria,23APQ@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3520539_23	356851.JOAN01000028_gene548	3.627e-114	376.0	COG1718@1|root,COG1718@2|Bacteria,2GM3J@201174|Actinobacteria,4D90V@85008|Micromonosporales	201174|Actinobacteria	DT	Serine threonine protein kinase involved in cell cycle control	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
TLS2_k127_3520539_1	263358.VAB18032_25780	0.0	1532.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4DBYB@85008|Micromonosporales	201174|Actinobacteria	C	aconitate hydratase	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS2_k127_3520539_9	656024.FsymDg_2113	1.002e-219	704.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4ERWJ@85013|Frankiales	201174|Actinobacteria	S	PFAM MMPL domain protein	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_3520539_55	1003195.SCAT_5665	1.385e-49	184.0	COG3404@1|root,COG3404@2|Bacteria,2IIRF@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Formiminotransferase-cyclodeaminase	-	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
TLS2_k127_3520539_50	1120950.KB892775_gene1190	4.569e-56	206.0	COG3187@1|root,COG3187@2|Bacteria,2I9ND@201174|Actinobacteria,4DUY5@85009|Propionibacteriales	201174|Actinobacteria	O	META domain	hslJ	-	-	ko:K03668	-	-	-	-	ko00000	-	-	-	META
TLS2_k127_3520539_6	345341.KUTG_00290	1.156e-260	831.0	COG0515@1|root,COG4403@1|root,COG0515@2|Bacteria,COG4403@2|Bacteria,2GMRN@201174|Actinobacteria,4E17J@85010|Pseudonocardiales	201174|Actinobacteria	KLTV	Lanthionine synthetase C-like protein	amfT	-	-	-	-	-	-	-	-	-	-	-	LANC_like,Pkinase
TLS2_k127_3520539_29	134676.ACPL_4534	2.03e-96	347.0	COG1506@1|root,COG1506@2|Bacteria,2GMBR@201174|Actinobacteria	201174|Actinobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
TLS2_k127_3520539_10	1123251.ATWM01000010_gene3008	4.435e-216	696.0	COG0147@1|root,COG0512@1|root,COG0147@2|Bacteria,COG0512@2|Bacteria,2GKJT@201174|Actinobacteria,4FE6P@85021|Intrasporangiaceae	201174|Actinobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	pabB	-	2.6.1.85,4.1.3.27,4.1.3.38	ko:K01657,ko:K01665,ko:K03342,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716,R05553	RC00010,RC01418,RC01843,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4,Anth_synt_I_N,Chorismate_bind,GATase
TLS2_k127_3520539_46	219305.MCAG_01728	3.717e-62	219.0	28JRZ@1|root,2Z9HI@2|Bacteria,2H9EF@201174|Actinobacteria,4DD50@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
TLS2_k127_3520539_2	1123322.KB904659_gene1029	0.0	1492.0	COG1643@1|root,COG1643@2|Bacteria,2GIWX@201174|Actinobacteria	201174|Actinobacteria	L	ATP-dependent helicase	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
TLS2_k127_3520539_37	1231391.AMZF01000020_gene2008	2.676e-85	297.0	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria	1224|Proteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_3520539_47	1231391.AMZF01000020_gene2009	6.011e-60	218.0	COG0559@1|root,COG0559@2|Bacteria,1P3FU@1224|Proteobacteria,2VPYC@28216|Betaproteobacteria,3T2PS@506|Alcaligenaceae	28216|Betaproteobacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_3520539_22	1231391.AMZF01000020_gene2010	2.119e-115	403.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUFT@1224|Proteobacteria	1224|Proteobacteria	E	(ABC) transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_3520539_40	1500301.JQMF01000038_gene5908	3.456e-79	271.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSA6@28211|Alphaproteobacteria,4BM3M@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_3520539_39	1120950.KB892823_gene455	1.037e-79	276.0	COG0679@1|root,COG0679@2|Bacteria,2GNIA@201174|Actinobacteria,4DPWX@85009|Propionibacteriales	201174|Actinobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
TLS2_k127_3520539_19	391037.Sare_1722	1.832e-126	413.0	COG1938@1|root,COG1938@2|Bacteria,2I2N7@201174|Actinobacteria,4DBJV@85008|Micromonosporales	201174|Actinobacteria	S	PAC2 family	pac	-	-	-	-	-	-	-	-	-	-	-	PAC2
TLS2_k127_3520539_8	356851.JOAN01000010_gene4594	1.965e-221	706.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,2GMC0@201174|Actinobacteria,4DAYB@85008|Micromonosporales	201174|Actinobacteria	L	DNA polymerase III, epsilon subunit	dnaQ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
TLS2_k127_3520539_52	1150864.MILUP08_40814	6.061e-54	194.0	COG2315@1|root,COG2315@2|Bacteria,2I2W9@201174|Actinobacteria,4DMDT@85008|Micromonosporales	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
TLS2_k127_3520539_43	644283.Micau_1726	5.956e-70	241.0	COG0346@1|root,COG0346@2|Bacteria,2IK75@201174|Actinobacteria,4DD54@85008|Micromonosporales	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_3520539_56	479432.Sros_3835	1.549e-40	158.0	COG0703@1|root,COG0703@2|Bacteria,2IQZ8@201174|Actinobacteria,4EK2Z@85012|Streptosporangiales	201174|Actinobacteria	E	Shikimate kinase	-	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
TLS2_k127_3520539_61	263358.VAB18032_13230	3.674e-32	135.0	2CK3K@1|root,32SBH@2|Bacteria,2I1E2@201174|Actinobacteria,4DEY1@85008|Micromonosporales	201174|Actinobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
TLS2_k127_3520539_14	477641.MODMU_1165	3.784e-172	552.0	COG1524@1|root,2Z9VM@2|Bacteria,2GWA2@201174|Actinobacteria,4EUKJ@85013|Frankiales	201174|Actinobacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3520539_36	266117.Rxyl_2783	3.172e-86	309.0	COG2202@1|root,COG5001@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,2GIZF@201174|Actinobacteria,4CRHY@84995|Rubrobacteria	84995|Rubrobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4
TLS2_k127_3520539_0	1121946.AUAX01000038_gene2638	0.0	1673.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4DA63@85008|Micromonosporales	201174|Actinobacteria	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS2_k127_3520539_42	35754.JNYJ01000014_gene4865	1.823e-72	258.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4DHJ2@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70 region 3	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_3520539_59	543632.JOJL01000011_gene6959	4.514e-34	141.0	COG3920@1|root,COG3920@2|Bacteria,2IT7M@201174|Actinobacteria,4DF1C@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,STAS_2
TLS2_k127_3520539_64	350054.Mflv_1029	1.161e-12	73.0	COG1366@1|root,COG1366@2|Bacteria,2GRXR@201174|Actinobacteria,23AJ8@1762|Mycobacteriaceae	201174|Actinobacteria	T	TIGRFAM anti-anti-sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
TLS2_k127_3520539_63	391037.Sare_1724	2.995e-23	101.0	2EPJV@1|root,33H6F@2|Bacteria,2IRJZ@201174|Actinobacteria,4DEZZ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3520539_41	1464048.JNZS01000016_gene3883	3.576e-79	282.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4DBSK@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family	-	-	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_3520539_26	644283.Micau_5181	3.571e-109	358.0	COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria,4DB2U@85008|Micromonosporales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_3520539_32	1123320.KB889683_gene2020	1.791e-93	313.0	COG1028@1|root,COG1028@2|Bacteria,2GMG3@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_3520539_51	1240349.ANGC01000009_gene2690	2.849e-55	202.0	2DZHZ@1|root,32VB7@2|Bacteria,2GPY2@201174|Actinobacteria,4FYYG@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3520539_24	35754.JNYJ01000002_gene6932	6.509e-113	372.0	COG2755@1|root,COG2755@2|Bacteria,2GMDE@201174|Actinobacteria,4DAS4@85008|Micromonosporales	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL,Lipase_GDSL_2
TLS2_k127_3520539_7	219305.MCAG_05467	1.259e-224	702.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4DA9I@85008|Micromonosporales	201174|Actinobacteria	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_3520539_53	134676.ACPL_5275	9.839e-51	197.0	2ECBY@1|root,336AB@2|Bacteria,2HU6P@201174|Actinobacteria,4DC62@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_128	1179773.BN6_65320	3.682e-05	57.0	COG0741@1|root,COG0741@2|Bacteria,2H8YR@201174|Actinobacteria	201174|Actinobacteria	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_27	644283.Micau_3351	1.311e-152	517.0	COG3227@1|root,COG3227@2|Bacteria,2I341@201174|Actinobacteria,4DBC0@85008|Micromonosporales	201174|Actinobacteria	E	Thermolysin metallopeptidase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	FTP,He_PIG,P_proprotein,PepSY,Peptidase_M4,Peptidase_M4_C
TLS2_k127_360973_83	1146883.BLASA_2742	1.371e-50	190.0	COG2044@1|root,COG2044@2|Bacteria,2HTZ6@201174|Actinobacteria,4EVPZ@85013|Frankiales	201174|Actinobacteria	S	PFAM DsrE DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_5	2002.JOEQ01000020_gene7143	5.777e-302	949.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_360973_60	35754.JNYJ01000033_gene2588	1.576e-85	294.0	COG1309@1|root,COG1309@2|Bacteria,2IIY2@201174|Actinobacteria,4DG9Q@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_360973_86	134676.ACPL_4421	1.173e-47	177.0	COG1917@1|root,COG1917@2|Bacteria,2IQ74@201174|Actinobacteria,4DJMB@85008|Micromonosporales	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_105	1313172.YM304_16750	5.83e-30	126.0	COG3467@1|root,COG3467@2|Bacteria,2IK9H@201174|Actinobacteria	201174|Actinobacteria	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_360973_41	326424.FRAAL1790	6.873e-113	373.0	COG2207@1|root,COG2207@2|Bacteria,2GK7Q@201174|Actinobacteria,4EUYJ@85013|Frankiales	201174|Actinobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
TLS2_k127_360973_61	1121946.AUAX01000033_gene5689	9.766e-85	285.0	COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria,4DD8E@85008|Micromonosporales	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	pmtA	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_360973_38	512565.AMIS_59500	1.392e-116	379.0	COG0346@1|root,COG0346@2|Bacteria,2IQB4@201174|Actinobacteria,4DCRA@85008|Micromonosporales	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_120	1150864.MILUP08_42379	5.991e-18	84.0	2EIY8@1|root,33CPE@2|Bacteria,2HUZP@201174|Actinobacteria,4DGEH@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_90	585531.HMPREF0063_12212	1.615e-39	160.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K07782	ko02020,ko02024,ko02026,map02020,map02024,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	GerE,Spo0A_C
TLS2_k127_360973_80	345341.KUTG_09185	5.335e-56	211.0	COG4585@1|root,COG4585@2|Bacteria,2GQQ8@201174|Actinobacteria,4E94E@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_360973_74	358823.DF19_01835	4.131e-69	241.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_360973_54	105420.BBPO01000011_gene1963	1.693e-98	332.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,2NHNG@228398|Streptacidiphilus	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_360973_92	1075090.GOAMR_64_00060	2.259e-38	155.0	COG0842@1|root,COG0842@2|Bacteria,2H2PR@201174|Actinobacteria	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_360973_34	644283.Micau_2746	6.91e-125	404.0	COG0500@1|root,COG0500@2|Bacteria,2I3K4@201174|Actinobacteria	201174|Actinobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
TLS2_k127_360973_9	1122611.KB903986_gene3995	3.272e-232	727.0	COG0044@1|root,COG0044@2|Bacteria,2GKEC@201174|Actinobacteria,4EMQV@85012|Streptosporangiales	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.2.2,3.5.2.3,3.5.2.5	ko:K01464,ko:K01465,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00051,M00546	R01993,R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
TLS2_k127_360973_24	1122611.KB903986_gene3996	1.816e-165	535.0	COG2079@1|root,COG2079@2|Bacteria,2GKUR@201174|Actinobacteria,4EGPF@85012|Streptosporangiales	201174|Actinobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
TLS2_k127_360973_85	35754.JNYJ01000062_gene1481	3.227e-49	189.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4DCS2@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_360973_17	644283.Micau_3749	5.681e-183	579.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4D936@85008|Micromonosporales	201174|Actinobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS2_k127_360973_95	330084.JNYZ01000017_gene5271	1.047e-34	144.0	COG1028@1|root,COG1028@2|Bacteria,2IDD0@201174|Actinobacteria,4E30X@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fabG1	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_360973_77	644283.Micau_3743	5.81e-62	222.0	COG1028@1|root,COG1028@2|Bacteria,2GP5U@201174|Actinobacteria,4DH5B@85008|Micromonosporales	201174|Actinobacteria	IQ	KR domain	-	-	1.1.1.100,1.3.1.28	ko:K00059,ko:K00216	ko00061,ko00333,ko00780,ko01040,ko01053,ko01100,ko01110,ko01130,ko01212,map00061,map00333,map00780,map01040,map01053,map01100,map01110,map01130,map01212	M00083,M00572	R01505,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117,RC00534	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_360973_52	675635.Psed_4192	7.145e-99	343.0	COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria,4DXKP@85010|Pseudonocardiales	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TLS2_k127_360973_40	1944.JOAZ01000033_gene187	1.708e-114	375.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,41C4I@629295|Streptomyces griseus group	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TLS2_k127_360973_44	675635.Psed_4190	8.056e-108	360.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria,4E27N@85010|Pseudonocardiales	201174|Actinobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TLS2_k127_360973_104	1944.JOAZ01000033_gene185	3.379e-30	126.0	COG1942@1|root,COG1942@2|Bacteria,2GRV2@201174|Actinobacteria	201174|Actinobacteria	S	4-Oxalocrotonate Tautomerase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_119	644283.Micau_3738	2.056e-19	93.0	2EMTU@1|root,33FG6@2|Bacteria,2ISK8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_32	1944.JOAZ01000033_gene183	2.296e-133	434.0	COG0500@1|root,COG2226@2|Bacteria,2IF41@201174|Actinobacteria	201174|Actinobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_360973_14	1463855.JOHV01000036_gene5810	1.266e-190	616.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria	201174|Actinobacteria	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8,Oxidored_FMN,Pyr_redox_2
TLS2_k127_360973_58	2002.JOEQ01000005_gene3803	2.075e-92	314.0	COG1878@1|root,COG1878@2|Bacteria,2GUSA@201174|Actinobacteria,4ENNF@85012|Streptosporangiales	201174|Actinobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_360973_59	2002.JOEQ01000005_gene3805	1.735e-87	296.0	COG1414@1|root,COG1414@2|Bacteria,2GM23@201174|Actinobacteria,4EP9K@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS2_k127_360973_91	504472.Slin_3140	1.487e-38	148.0	COG1764@1|root,COG1764@2|Bacteria,4NNVC@976|Bacteroidetes,47QWH@768503|Cytophagia	976|Bacteroidetes	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_360973_2	1121926.AXWO01000021_gene2327	0.0	1108.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4EZE6@85014|Glycomycetales	201174|Actinobacteria	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
TLS2_k127_360973_76	1907.SGLAU_19300	1.571e-64	224.0	COG1247@1|root,COG1247@2|Bacteria,2H1MI@201174|Actinobacteria	201174|Actinobacteria	M	Sortase and related acyltransferases	ywnH	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
TLS2_k127_360973_94	649831.L083_3454	2.035e-36	143.0	COG0071@1|root,COG0071@2|Bacteria,2GQGQ@201174|Actinobacteria,4DEMD@85008|Micromonosporales	201174|Actinobacteria	O	Hsp20/alpha crystallin family	hspX	GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016310,GO:0019538,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0036294,GO:0040007,GO:0040008,GO:0042221,GO:0042594,GO:0043170,GO:0043207,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045926,GO:0046777,GO:0048519,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0071496,GO:0071704,GO:0071944,GO:0075136,GO:1901564	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS2_k127_360973_100	55952.BU52_07685	4.752e-32	130.0	COG1765@1|root,COG1765@2|Bacteria,2IFY4@201174|Actinobacteria	201174|Actinobacteria	O	PFAM OsmC family protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_360973_117	2074.JNYD01000011_gene137	1.208e-20	96.0	2EH65@1|root,3351X@2|Bacteria,2GQUG@201174|Actinobacteria,4E74D@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF1876)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1876
TLS2_k127_360973_71	263358.VAB18032_21245	7.891e-73	254.0	COG0517@1|root,COG0517@2|Bacteria,2GKSH@201174|Actinobacteria,4DDF0@85008|Micromonosporales	201174|Actinobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
TLS2_k127_360973_65	35754.JNYJ01000052_gene6646	2.968e-80	276.0	COG1366@1|root,COG1366@2|Bacteria,2IDMU@201174|Actinobacteria,4DCR0@85008|Micromonosporales	201174|Actinobacteria	T	MEDS: MEthanogen/methylotroph, DcmR Sensory domain	-	-	-	-	-	-	-	-	-	-	-	-	MEDS,STAS_2
TLS2_k127_360973_108	1121946.AUAX01000036_gene1883	6.644e-28	119.0	COG2172@1|root,COG2172@2|Bacteria,2GQJD@201174|Actinobacteria,4DM9Q@85008|Micromonosporales	201174|Actinobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
TLS2_k127_360973_29	35754.JNYJ01000042_gene1378	4.635e-141	467.0	COG0309@1|root,COG0309@2|Bacteria,2GJ7N@201174|Actinobacteria,4DHG8@85008|Micromonosporales	201174|Actinobacteria	O	AIR synthase related protein, C-terminal domain	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
TLS2_k127_360973_15	1125971.ASJB01000031_gene1301	1.471e-187	591.0	COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria,4DYZ6@85010|Pseudonocardiales	201174|Actinobacteria	O	hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
TLS2_k127_360973_106	1214101.BN159_8142	4.413e-28	124.0	COG0298@1|root,COG0298@2|Bacteria,2IMSQ@201174|Actinobacteria	201174|Actinobacteria	O	Hydrogenase expression formation protein	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
TLS2_k127_360973_7	1120950.KB892757_gene6506	2.758e-259	820.0	COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria,4DTBQ@85009|Propionibacteriales	201174|Actinobacteria	O	HypF finger	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
TLS2_k127_360973_96	35754.JNYJ01000042_gene1372	1.212e-34	145.0	COG0680@1|root,COG0680@2|Bacteria,2IJ3P@201174|Actinobacteria	201174|Actinobacteria	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
TLS2_k127_360973_11	35754.JNYJ01000042_gene1373	9.153e-199	633.0	COG3259@1|root,COG3259@2|Bacteria,2GQ33@201174|Actinobacteria,4DABR@85008|Micromonosporales	201174|Actinobacteria	C	Nickel-dependent hydrogenase	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
TLS2_k127_360973_46	469371.Tbis_1859	3.166e-105	346.0	COG1941@1|root,COG1941@2|Bacteria,2GSPN@201174|Actinobacteria,4E2HS@85010|Pseudonocardiales	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
TLS2_k127_360973_56	1298880.AUEV01000004_gene1986	8.901e-98	328.0	COG0543@1|root,COG0543@2|Bacteria,2HXFY@201174|Actinobacteria	201174|Actinobacteria	CH	Oxidoreductase	asrB	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
TLS2_k127_360973_28	1172180.KB911792_gene3758	1.503e-151	489.0	COG1143@1|root,COG1143@2|Bacteria,2GMEQ@201174|Actinobacteria	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
TLS2_k127_360973_12	405948.SACE_2420	3.39e-195	613.0	COG1980@1|root,COG1980@2|Bacteria,2IDT3@201174|Actinobacteria,4E8I7@85010|Pseudonocardiales	201174|Actinobacteria	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
TLS2_k127_360973_36	1123023.JIAI01000022_gene2300	9.392e-121	405.0	COG1807@1|root,COG1807@2|Bacteria,2GK3Q@201174|Actinobacteria,4DZ07@85010|Pseudonocardiales	201174|Actinobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_360973_57	1206732.BAGD01000277_gene6287	5.076e-95	319.0	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,4FYCV@85025|Nocardiaceae	201174|Actinobacteria	IQ	KR domain	-	-	1.1.1.53	ko:K00038	ko00140,ko01100,map00140,map01100	-	R04831,R04834,R04844,R04847	RC00139,RC01219,RC01220	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
TLS2_k127_360973_39	43759.JNWK01000009_gene4886	5.321e-115	385.0	COG0654@1|root,COG0654@2|Bacteria,2GK7I@201174|Actinobacteria	201174|Actinobacteria	CH	tryptophan 2,3-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_73	469383.Cwoe_2260	1.869e-69	243.0	COG0428@1|root,COG0428@2|Bacteria,2GISJ@201174|Actinobacteria,4CQDI@84995|Rubrobacteria	84995|Rubrobacteria	P	zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	-
TLS2_k127_360973_107	1869.MB27_02565	4.691e-28	119.0	COG3339@1|root,COG3339@2|Bacteria,2GQGT@201174|Actinobacteria,4DEFZ@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
TLS2_k127_360973_88	35754.JNYJ01000058_gene8632	7.56e-44	170.0	COG0741@1|root,COG0741@2|Bacteria,2HEMX@201174|Actinobacteria,4DG75@85008|Micromonosporales	201174|Actinobacteria	M	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_55	44060.JODL01000016_gene4465	4.206e-98	331.0	COG2423@1|root,COG2423@2|Bacteria,2H4D8@201174|Actinobacteria	201174|Actinobacteria	E	ornithine cyclodeaminase	ocd	-	1.5.1.51,4.3.1.12	ko:K01750,ko:K21721	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
TLS2_k127_360973_69	68199.JNZO01000002_gene1528	1.941e-75	265.0	COG0031@1|root,COG0031@2|Bacteria,2GK6J@201174|Actinobacteria	201174|Actinobacteria	E	cysteine synthase	-	-	-	-	-	-	-	-	-	-	-	-	PALP
TLS2_k127_360973_51	1121946.AUAX01000002_gene111	5.33e-101	336.0	COG1262@1|root,COG1262@2|Bacteria,2GK9Q@201174|Actinobacteria,4D9VE@85008|Micromonosporales	201174|Actinobacteria	C	Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TLS2_k127_360973_67	222534.KB893729_gene5720	7.423e-76	269.0	COG2124@1|root,COG2124@2|Bacteria,2GNJI@201174|Actinobacteria,4EUHG@85013|Frankiales	201174|Actinobacteria	Q	PFAM Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_360973_0	1121946.AUAX01000002_gene95	0.0	1965.0	COG0318@1|root,COG1020@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,2GISR@201174|Actinobacteria	201174|Actinobacteria	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl-CoA_dh_1,Acyl-CoA_dh_M,Condensation,PP-binding
TLS2_k127_360973_4	1121946.AUAX01000002_gene96	8.001e-317	1005.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4D8GT@85008|Micromonosporales	201174|Actinobacteria	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,TauD,Thioesterase
TLS2_k127_360973_10	1089545.KB913037_gene9111	2.971e-212	732.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4EA1N@85010|Pseudonocardiales	201174|Actinobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Beta-lactamase,Condensation,PP-binding,Thioesterase
TLS2_k127_360973_8	1121946.AUAX01000002_gene99	1.012e-240	768.0	COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4DBHN@85008|Micromonosporales	201174|Actinobacteria	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS2_k127_360973_22	1121946.AUAX01000002_gene100	5.012e-175	569.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4DIIM@85008|Micromonosporales	201174|Actinobacteria	Q	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
TLS2_k127_360973_18	1121946.AUAX01000002_gene101	7.488e-183	584.0	COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,4DCRF@85008|Micromonosporales	201174|Actinobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_360973_70	1121946.AUAX01000002_gene107	2.007e-75	264.0	COG3208@1|root,COG3208@2|Bacteria,2IGE0@201174|Actinobacteria,4DERC@85008|Micromonosporales	201174|Actinobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioesterase
TLS2_k127_360973_126	446462.Amir_5393	3.861e-08	56.0	COG0464@1|root,COG0464@2|Bacteria,2I8CR@201174|Actinobacteria,4DYJC@85010|Pseudonocardiales	201174|Actinobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
TLS2_k127_360973_6	1136417.AZWE01000002_gene3603	4.922e-265	846.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,2GIT4@201174|Actinobacteria,4D9ZF@85008|Micromonosporales	201174|Actinobacteria	CP	Na H antiporter	mnhB	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,NADHdh,Proton_antipo_M,Proton_antipo_N
TLS2_k127_360973_97	526225.Gobs_2929	3.9e-34	136.0	COG1006@1|root,COG1006@2|Bacteria,2IR2B@201174|Actinobacteria	201174|Actinobacteria	P	Multisubunit Na H antiporter MnhC subunit	mnhC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
TLS2_k127_360973_25	1906.SFRA_30525	4.243e-157	510.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria	201174|Actinobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	mnhD	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
TLS2_k127_360973_112	1906.SFRA_30520	1.303e-24	110.0	COG1863@1|root,COG1863@2|Bacteria	2|Bacteria	P	multisubunit Na H antiporter MnhE subunit	mrpE	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
TLS2_k127_360973_118	526225.Gobs_2932	5.997e-20	92.0	COG2212@1|root,COG2212@2|Bacteria,2H19H@201174|Actinobacteria	201174|Actinobacteria	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
TLS2_k127_360973_116	526225.Gobs_2933	8.506e-23	106.0	COG1320@1|root,COG1320@2|Bacteria,2GRNP@201174|Actinobacteria	201174|Actinobacteria	P	monovalent cation proton antiporter, MnhG PhaG subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
TLS2_k127_360973_43	446470.Snas_4874	2.089e-111	376.0	COG0642@1|root,COG3850@1|root,COG0642@2|Bacteria,COG3850@2|Bacteria,2GMHQ@201174|Actinobacteria,4EZ86@85014|Glycomycetales	201174|Actinobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_360973_49	1246995.AFR_10220	9.54e-102	336.0	COG0745@1|root,COG0745@2|Bacteria,2GMVN@201174|Actinobacteria,4D8W6@85008|Micromonosporales	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_360973_125	263358.VAB18032_10285	1.181e-12	74.0	COG3416@1|root,COG3416@2|Bacteria,2IRHB@201174|Actinobacteria,4DEUR@85008|Micromonosporales	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_68	263358.VAB18032_00025	1.29e-75	268.0	COG3571@1|root,COG3571@2|Bacteria,2GKKE@201174|Actinobacteria,4DCSP@85008|Micromonosporales	201174|Actinobacteria	S	Hydrolase of the alpha beta-hydrolase	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	DLH
TLS2_k127_360973_23	292459.STH2102	1.515e-172	561.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1TQ85@1239|Firmicutes,25B1P@186801|Clostridia	186801|Clostridia	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_360973_3	219305.MCAG_01112	0.0	1060.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,4D8SA@85008|Micromonosporales	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
TLS2_k127_360973_101	1150864.MILUP08_44972	6.644e-31	128.0	COG2146@1|root,COG2146@2|Bacteria,2IKSY@201174|Actinobacteria,4DE1H@85008|Micromonosporales	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
TLS2_k127_360973_1	391037.Sare_3339	0.0	1716.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4DA8S@85008|Micromonosporales	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_360973_122	284031.JNXD01000001_gene5376	4.226e-15	78.0	COG2197@1|root,COG2197@2|Bacteria,2GZ0M@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_360973_62	68219.JNXI01000003_gene4456	9.8e-83	283.0	COG0500@1|root,COG2226@2|Bacteria,2I35J@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_360973_81	68219.JNXI01000003_gene4453	6.709e-55	201.0	2EUZG@1|root,33NEP@2|Bacteria,2IIGU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_16	68219.JNXI01000003_gene4454	3.17e-186	601.0	COG0400@1|root,COG0400@2|Bacteria,2GJH6@201174|Actinobacteria	201174|Actinobacteria	S	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
TLS2_k127_360973_98	1464048.JNZS01000053_gene2380	7.503e-33	136.0	COG1162@1|root,COG1162@2|Bacteria,2GMDX@201174|Actinobacteria,4DBP0@85008|Micromonosporales	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
TLS2_k127_360973_53	512565.AMIS_60050	8.532e-99	337.0	COG2208@1|root,COG2208@2|Bacteria,2GNG4@201174|Actinobacteria,4DFGC@85008|Micromonosporales	201174|Actinobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
TLS2_k127_360973_45	644283.Micau_4348	7.14e-107	349.0	COG0491@1|root,COG0491@2|Bacteria,2GKJA@201174|Actinobacteria,4D9PG@85008|Micromonosporales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_360973_20	1150864.MILUP08_41490	3.534e-177	563.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4D9EF@85008|Micromonosporales	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
TLS2_k127_360973_124	67373.JOBF01000013_gene4083	4.065e-13	79.0	COG0500@1|root,COG2226@2|Bacteria,2GKPQ@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
TLS2_k127_360973_30	1121272.KB903283_gene5004	1.449e-140	456.0	COG0715@1|root,COG0715@2|Bacteria,2I95I@201174|Actinobacteria	201174|Actinobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_48	211114.JOEF01000037_gene6877	5.538e-102	346.0	COG0600@1|root,COG0600@2|Bacteria,2IBTW@201174|Actinobacteria,4EENX@85010|Pseudonocardiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TLS2_k127_360973_63	1160137.KB907307_gene3171	5.126e-82	281.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4FWY4@85025|Nocardiaceae	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TLS2_k127_360973_115	1122182.KB903837_gene3785	4.873e-23	113.0	COG1396@1|root,COG1396@2|Bacteria,2I7MK@201174|Actinobacteria,4DKF5@85008|Micromonosporales	201174|Actinobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_111	994479.GL877878_gene1561	5.315e-25	109.0	2EH65@1|root,3351X@2|Bacteria,2GQUG@201174|Actinobacteria,4E74D@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF1876)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1876
TLS2_k127_360973_72	644283.Micau_4437	1.012e-71	248.0	COG0243@1|root,COG0243@2|Bacteria,2GJ62@201174|Actinobacteria,4DD04@85008|Micromonosporales	201174|Actinobacteria	C	molybdopterin cofactor binding	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
TLS2_k127_360973_93	479435.Kfla_7038	4.7e-37	153.0	2DG3P@1|root,2ZUBI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_19	1150864.MILUP08_43107	4.72e-178	565.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4D9C3@85008|Micromonosporales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinP	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
TLS2_k127_360973_35	1001240.GY21_07900	4.312e-121	401.0	COG0624@1|root,COG0624@2|Bacteria,2GJDE@201174|Actinobacteria,4FP5Y@85023|Microbacteriaceae	201174|Actinobacteria	E	Peptidase family M20/M25/M40	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_360973_82	298655.KI912266_gene494	1.318e-50	181.0	COG0662@1|root,COG0662@2|Bacteria,2IMHT@201174|Actinobacteria	201174|Actinobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,EutQ
TLS2_k127_360973_50	1136417.AZWE01000018_gene984	2.502e-101	338.0	COG0785@1|root,COG0785@2|Bacteria,2I8T6@201174|Actinobacteria,4DD39@85008|Micromonosporales	201174|Actinobacteria	O	Cytochrome c biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
TLS2_k127_360973_84	1246995.AFR_12375	8.102e-50	184.0	COG0526@1|root,COG0526@2|Bacteria,2IR6C@201174|Actinobacteria,4DF6H@85008|Micromonosporales	201174|Actinobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_360973_37	1150864.MILUP08_44084	2.555e-119	394.0	COG0642@1|root,COG2205@2|Bacteria,2I3JI@201174|Actinobacteria,4DMR4@85008|Micromonosporales	201174|Actinobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_360973_47	391037.Sare_1090	1.153e-102	338.0	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria,4D8U9@85008|Micromonosporales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	resD	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_360973_26	1121946.AUAX01000036_gene1926	5.022e-156	506.0	COG1404@1|root,COG3055@1|root,COG1404@2|Bacteria,COG3055@2|Bacteria,2IF2T@201174|Actinobacteria,4DBYG@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Kelch_1,Peptidase_S8
TLS2_k127_360973_109	35754.JNYJ01000019_gene107	3.489e-26	111.0	COG3251@1|root,COG3251@2|Bacteria,2GQIK@201174|Actinobacteria,4DFYE@85008|Micromonosporales	201174|Actinobacteria	S	MbtH domain protein	-	-	-	ko:K05375	ko00261,ko01130,map00261,map01130	M00736	R10880	RC00064,RC00141,RC03296,RC03297,RC03298	ko00000,ko00001,ko00002	-	-	-	MbtH
TLS2_k127_360973_102	28444.JODQ01000005_gene1459	1.296e-30	128.0	2AGZ4@1|root,3177X@2|Bacteria,2H7K2@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_64	219305.MCAG_00231	1.262e-81	284.0	COG1196@1|root,COG1196@2|Bacteria,2I5H7@201174|Actinobacteria,4DBSF@85008|Micromonosporales	201174|Actinobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	DivIVA
TLS2_k127_360973_127	105425.BBPL01000016_gene2534	3.77e-06	49.0	COG4403@1|root,COG4403@2|Bacteria,2GKVV@201174|Actinobacteria,2NI0D@228398|Streptacidiphilus	201174|Actinobacteria	V	Domain of unknown function (DUF4135)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4135,LANC_like
TLS2_k127_360973_99	1463861.JNXE01000017_gene7743	3.631e-32	131.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator, SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,NB-ARC,TPR_10,TPR_12,Trans_reg_C
TLS2_k127_360973_121	649831.L083_1385	3.374e-16	85.0	2EI4A@1|root,33BVN@2|Bacteria,2GX45@201174|Actinobacteria,4DGEI@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_21	1144275.COCOR_05894	5.693e-176	560.0	COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,437V1@68525|delta/epsilon subdivisions,2X34I@28221|Deltaproteobacteria,2YU7X@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_360973_79	1385517.N800_07695	3.699e-58	214.0	COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,1S69N@1236|Gammaproteobacteria,1X6M5@135614|Xanthomonadales	135614|Xanthomonadales	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_360973_87	512565.AMIS_1650	1.221e-45	168.0	COG1970@1|root,COG1970@2|Bacteria,2IQDN@201174|Actinobacteria,4DEEE@85008|Micromonosporales	201174|Actinobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
TLS2_k127_360973_78	266117.Rxyl_2397	1.233e-60	229.0	COG3324@1|root,COG3324@2|Bacteria,2GJFC@201174|Actinobacteria,4CQEZ@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_360973_33	1380356.JNIK01000011_gene2036	2.733e-133	439.0	COG0671@1|root,COG1597@1|root,COG0671@2|Bacteria,COG1597@2|Bacteria,2GM2U@201174|Actinobacteria,4ES4W@85013|Frankiales	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	DAGK_cat,PAP2
TLS2_k127_360973_42	263358.VAB18032_28356	4.999e-112	366.0	COG1028@1|root,COG1028@2|Bacteria,2GKE1@201174|Actinobacteria,4DAKD@85008|Micromonosporales	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_360973_75	1150864.MILUP08_30109	1.044e-68	239.0	2C7PT@1|root,2ZXN2@2|Bacteria,2GM64@201174|Actinobacteria,4DG8K@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_360973_13	1380393.JHVP01000002_gene1923	2.071e-192	632.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria	201174|Actinobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
TLS2_k127_360973_89	1223543.GP2_033_00310	1.155e-41	156.0	COG0251@1|root,COG5637@1|root,COG0251@2|Bacteria,COG5637@2|Bacteria,2IN7X@201174|Actinobacteria,4GEKW@85026|Gordoniaceae	201174|Actinobacteria	J	polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_360973_66	2002.JOEQ01000040_gene6091	7.709e-78	271.0	COG2977@1|root,COG2977@2|Bacteria,2IIA2@201174|Actinobacteria,4EJMA@85012|Streptosporangiales	201174|Actinobacteria	Q	4'-phosphopantetheinyl transferase superfamily	pptA	-	-	-	-	-	-	-	-	-	-	-	ACPS
TLS2_k127_360973_31	1303692.SFUL_6773	2.41e-134	433.0	COG1409@1|root,COG1409@2|Bacteria,2GKMR@201174|Actinobacteria	201174|Actinobacteria	Q	metallophosphoesterase	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	Metallophos
TLS2_k127_360973_113	1121946.AUAX01000012_gene6648	1.631e-24	114.0	2DD7T@1|root,2ZGY7@2|Bacteria,2I1CJ@201174|Actinobacteria,4DGE4@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_360973_103	1120949.KB903317_gene1735	2.568e-30	136.0	COG2197@1|root,COG2197@2|Bacteria,2H7AA@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_390980_5	1906.SFRA_11885	4.912e-15	77.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter substrate-binding protein	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_390980_1	1122182.KB903837_gene3870	7.347e-125	413.0	COG1175@1|root,COG1175@2|Bacteria,2GKYS@201174|Actinobacteria,4DBI0@85008|Micromonosporales	201174|Actinobacteria	P	transport systems	aglF	-	-	ko:K02025,ko:K10233	ko02010,map02010	M00201,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1,CarboxypepD_reg
TLS2_k127_390980_2	1236902.ANAS01000037_gene5388	9.339e-111	373.0	COG0395@1|root,COG0395@2|Bacteria,2GJNN@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	aglG	-	-	ko:K02026,ko:K10234	ko02010,map02010	M00201,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
TLS2_k127_390980_4	33876.JNXY01000031_gene3012	1.003e-73	256.0	COG3300@1|root,COG3300@2|Bacteria,2GMG6@201174|Actinobacteria,4DD5S@85008|Micromonosporales	201174|Actinobacteria	T	Bacterial signalling protein N terminal repeat	-	-	-	-	-	-	-	-	-	-	-	-	MHYT
TLS2_k127_390980_3	1246995.AFR_07075	4.432e-77	270.0	COG1028@1|root,COG1028@2|Bacteria,2IFUD@201174|Actinobacteria,4D8PP@85008|Micromonosporales	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	ywfD	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
TLS2_k127_390980_0	1229203.KI301992_gene1447	5.319e-126	408.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,3UWCE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	hrdD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_3953214_53	1121272.KB903292_gene3797	1.317e-57	206.0	COG4549@1|root,COG4549@2|Bacteria,2GN9H@201174|Actinobacteria,4DBFT@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unkown function (DUF1775)	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF1775
TLS2_k127_3953214_13	1150864.MILUP08_41288	1.175e-168	550.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2GMKG@201174|Actinobacteria,4D8PB@85008|Micromonosporales	201174|Actinobacteria	P	resistance protein CopC	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
TLS2_k127_3953214_40	391037.Sare_1005	9.049e-82	277.0	COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,4D9TD@85008|Micromonosporales	201174|Actinobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS2_k127_3953214_78	446470.Snas_0984	1.621e-22	109.0	2C87M@1|root,33MK7@2|Bacteria	446470.Snas_0984|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3953214_70	446470.Snas_0983	2.432e-32	131.0	2EPJ7@1|root,33H5V@2|Bacteria,2GV35@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3953214_76	408672.NBCG_04636	1.621e-25	121.0	2DMM0@1|root,32SAU@2|Bacteria,2IQMM@201174|Actinobacteria,4DSWD@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3953214_20	219305.MCAG_04111	1.233e-129	418.0	COG4122@1|root,COG4122@2|Bacteria,2IEVU@201174|Actinobacteria,4DHC4@85008|Micromonosporales	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
TLS2_k127_3953214_4	369723.Strop_1110	1.064e-306	949.0	COG2987@1|root,COG2987@2|Bacteria,2GP10@201174|Actinobacteria,4D9Y2@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
TLS2_k127_3953214_16	1463821.JOGR01000006_gene2761	1.476e-161	518.0	COG0624@1|root,COG0624@2|Bacteria,2GJDE@201174|Actinobacteria,4EXXW@85014|Glycomycetales	201174|Actinobacteria	E	Peptidase family M28	amaB	-	3.5.1.6,3.5.1.87,3.5.3.9	ko:K02083,ko:K06016	ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120	M00046	R00905,R02423,R04666	RC00064,RC00096	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_3953214_12	356851.JOAN01000003_gene1381	1.604e-176	569.0	COG0402@1|root,COG0402@2|Bacteria,2GZ2Q@201174|Actinobacteria,4DAQ9@85008|Micromonosporales	201174|Actinobacteria	F	deiminase	hutF	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_3953214_10	219305.MCAG_04101	2.146e-189	597.0	COG1228@1|root,COG1228@2|Bacteria,2GJH4@201174|Actinobacteria,4DBJ2@85008|Micromonosporales	201174|Actinobacteria	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
TLS2_k127_3953214_5	134676.ACPL_1173	9.619e-250	779.0	COG2986@1|root,COG2986@2|Bacteria,2GJZW@201174|Actinobacteria,4D8MX@85008|Micromonosporales	201174|Actinobacteria	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
TLS2_k127_3953214_73	65497.JODV01000006_gene845	1.833e-28	130.0	COG2374@1|root,COG2374@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,LTD
TLS2_k127_3953214_82	28444.JODQ01000005_gene1477	2.932e-07	61.0	COG4719@1|root,COG4719@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
TLS2_k127_3953214_38	263358.VAB18032_10395	1.721e-83	282.0	COG0127@1|root,COG0127@2|Bacteria,2GM2B@201174|Actinobacteria,4DCA5@85008|Micromonosporales	201174|Actinobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
TLS2_k127_3953214_23	219305.MCAG_04098	4.612e-125	405.0	COG0689@1|root,COG0689@2|Bacteria,2GJFI@201174|Actinobacteria,4DC2I@85008|Micromonosporales	201174|Actinobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
TLS2_k127_3953214_49	1136417.AZWE01000034_gene523	1.993e-59	214.0	COG1443@1|root,COG1443@2|Bacteria,2GM26@201174|Actinobacteria,4DCXC@85008|Micromonosporales	201174|Actinobacteria	I	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)	idi	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
TLS2_k127_3953214_41	479432.Sros_5550	1.424e-81	290.0	COG1295@1|root,COG1295@2|Bacteria,2GN79@201174|Actinobacteria,4EMNT@85012|Streptosporangiales	201174|Actinobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_3953214_69	446470.Snas_6443	2.036e-37	146.0	2D19V@1|root,334ZZ@2|Bacteria,2I39B@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3953214_17	1246995.AFR_06360	1.92e-136	437.0	COG1234@1|root,COG1234@2|Bacteria,2GMEX@201174|Actinobacteria,4DAXV@85008|Micromonosporales	201174|Actinobacteria	S	beta-lactamase domain protein	yhfI	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_3953214_27	1121946.AUAX01000014_gene1243	2.882e-114	387.0	COG0796@1|root,COG0796@2|Bacteria,2GN4I@201174|Actinobacteria,4DAB2@85008|Micromonosporales	201174|Actinobacteria	M	Asp/Glu/Hydantoin racemase	murI	GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
TLS2_k127_3953214_11	512565.AMIS_9430	1.068e-187	590.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4D9WT@85008|Micromonosporales	201174|Actinobacteria	E	Cysteine synthase	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113	ko:K21148	ko04122,map04122	-	R10610	RC03225	ko00000,ko00001,ko01000	-	-	-	PALP
TLS2_k127_3953214_67	1464048.JNZS01000008_gene6170	1.648e-42	158.0	COG1977@1|root,COG1977@2|Bacteria,2IQBT@201174|Actinobacteria,4DE3Z@85008|Micromonosporales	201174|Actinobacteria	H	ThiS family	cysO	GO:0000096,GO:0000097,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS2_k127_3953214_42	1122182.KB903813_gene2756	3.877e-80	269.0	COG1310@1|root,COG1310@2|Bacteria,2IFB5@201174|Actinobacteria,4DCI4@85008|Micromonosporales	201174|Actinobacteria	S	Mov34 MPN PAD-1 family	mec	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006508,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016787,GO:0019344,GO:0019538,GO:0019752,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
TLS2_k127_3953214_14	97096.XP_007790920.1	4.039e-165	537.0	COG1574@1|root,2RS8Z@2759|Eukaryota,3918Y@33154|Opisthokonta,3PXJ9@4751|Fungi,3RGKA@4890|Ascomycota,21EIX@147550|Sordariomycetes	4751|Fungi	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_3953214_30	97096.XP_007790920.1	3.392e-107	373.0	COG1574@1|root,2RS8Z@2759|Eukaryota,3918Y@33154|Opisthokonta,3PXJ9@4751|Fungi,3RGKA@4890|Ascomycota,21EIX@147550|Sordariomycetes	4751|Fungi	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_3953214_45	1246995.AFR_06330	1.067e-69	239.0	2E4AX@1|root,32Z6K@2|Bacteria,2GW4T@201174|Actinobacteria,4DCRJ@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF2017)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2017
TLS2_k127_3953214_65	644283.Micau_1154	1.751e-44	179.0	COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria,4DE4D@85008|Micromonosporales	201174|Actinobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
TLS2_k127_3953214_8	644283.Micau_1151	1.372e-209	657.0	COG1488@1|root,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria,4DAUF@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0030312,GO:0034355,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C
TLS2_k127_3953214_39	1869.MB27_01760	4.379e-82	278.0	COG1335@1|root,COG1335@2|Bacteria,2IFQW@201174|Actinobacteria,4DC17@85008|Micromonosporales	201174|Actinobacteria	Q	isochorismatase hydrolase	pncA	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
TLS2_k127_3953214_3	1464048.JNZS01000008_gene6179	1.693e-320	989.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4DASP@85008|Micromonosporales	201174|Actinobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS2_k127_3953214_19	591158.SSMG_04763	7.669e-130	450.0	COG0577@1|root,COG0577@2|Bacteria,2IE56@201174|Actinobacteria	201174|Actinobacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_3953214_54	1380393.JHVP01000012_gene2806	2.131e-56	205.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4EU28@85013|Frankiales	201174|Actinobacteria	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3953214_64	477641.MODMU_0851	7.411e-46	177.0	COG1136@1|root,COG1136@2|Bacteria,2I6MC@201174|Actinobacteria	201174|Actinobacteria	V	Product type t transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_3953214_55	1463853.JOHW01000006_gene4566	3.521e-56	216.0	COG0265@1|root,COG0265@2|Bacteria,2I497@201174|Actinobacteria	201174|Actinobacteria	O	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3953214_22	710111.FraQA3DRAFT_0130	3.545e-127	417.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria	201174|Actinobacteria	O	ATPase associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
TLS2_k127_3953214_2	749414.SBI_00665	0.0	1095.0	COG0457@1|root,COG0457@2|Bacteria,2GIWN@201174|Actinobacteria	201174|Actinobacteria	D	FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,TPR_10,TPR_12
TLS2_k127_3953214_25	749927.AMED_7897	9.736e-124	419.0	COG0641@1|root,COG0641@2|Bacteria,2I2SE@201174|Actinobacteria,4E115@85010|Pseudonocardiales	201174|Actinobacteria	C	radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3953214_81	1463853.JOHW01000006_gene4561	6.968e-08	57.0	2B5N9@1|root,31YHJ@2|Bacteria,2H0T6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3953214_63	443255.SCLAV_p1106	7.682e-48	187.0	COG1075@1|root,COG2755@1|root,COG1075@2|Bacteria,COG2755@2|Bacteria,2IQ2F@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
TLS2_k127_3953214_56	106370.Francci3_2431	2.145e-53	191.0	COG0494@1|root,COG0494@2|Bacteria,2I56M@201174|Actinobacteria	201174|Actinobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_3953214_35	644283.Micau_5493	2.796e-87	293.0	COG2813@1|root,COG2813@2|Bacteria,2IFG7@201174|Actinobacteria,4DAF5@85008|Micromonosporales	201174|Actinobacteria	J	methyltransferase small	rsmC	-	2.1.1.172	ko:K00564	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS
TLS2_k127_3953214_57	35754.JNYJ01000004_gene5945	7.379e-52	206.0	2F46X@1|root,33WXY@2|Bacteria,2HUBP@201174|Actinobacteria,4DE26@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3953214_28	644283.Micau_5495	1.547e-110	364.0	COG0101@1|root,COG0101@2|Bacteria,2GJ6C@201174|Actinobacteria,4DC99@85008|Micromonosporales	201174|Actinobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
TLS2_k127_3953214_51	35754.JNYJ01000004_gene5947	3.487e-59	212.0	COG0203@1|root,COG0203@2|Bacteria,2IHV2@201174|Actinobacteria,4DAIX@85008|Micromonosporales	201174|Actinobacteria	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
TLS2_k127_3953214_9	33876.JNXY01000022_gene4506	1.114e-192	605.0	COG0202@1|root,COG0202@2|Bacteria,2GJJ5@201174|Actinobacteria,4D8VE@85008|Micromonosporales	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
TLS2_k127_3953214_26	644283.Micau_5498	2.97e-116	377.0	COG0522@1|root,COG0522@2|Bacteria,2GIRX@201174|Actinobacteria,4D9VD@85008|Micromonosporales	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
TLS2_k127_3953214_43	1121272.KB903250_gene2981	5.045e-75	253.0	COG0100@1|root,COG0100@2|Bacteria,2IFFC@201174|Actinobacteria,4DCRK@85008|Micromonosporales	201174|Actinobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
TLS2_k127_3953214_52	266940.Krad_0713	5.406e-59	209.0	COG0099@1|root,COG0099@2|Bacteria,2IHPN@201174|Actinobacteria	201174|Actinobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
TLS2_k127_3953214_80	58123.JOFJ01000024_gene3475	3.869e-16	78.0	COG0257@1|root,COG0257@2|Bacteria,2GWMH@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
TLS2_k127_3953214_62	369723.Strop_3900	4.954e-48	175.0	COG0361@1|root,COG0361@2|Bacteria,2IQ4B@201174|Actinobacteria,4DF19@85008|Micromonosporales	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071944	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
TLS2_k127_3953214_75	35754.JNYJ01000004_gene5954	6.425e-28	118.0	COG1008@1|root,COG1008@2|Bacteria,2GR9E@201174|Actinobacteria,4DE5Y@85008|Micromonosporales	201174|Actinobacteria	C	Domain of unknown function (DUF1707)	-	-	-	-	-	-	-	-	-	-	-	-	2TM,DUF1707
TLS2_k127_3953214_21	644283.Micau_5505	2.117e-129	418.0	COG0024@1|root,COG0024@2|Bacteria,2GKKB@201174|Actinobacteria,4DAAK@85008|Micromonosporales	201174|Actinobacteria	E	Methionine aminopeptidase	mapA	GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016020,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901605	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS2_k127_3953214_24	33876.JNXY01000022_gene4513	1.04e-124	401.0	COG0563@1|root,COG0563@2|Bacteria,2GJ7T@201174|Actinobacteria,4DB8D@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
TLS2_k127_3953214_7	369723.Strop_3903	1.229e-212	667.0	COG0201@1|root,COG0201@2|Bacteria,2GJ26@201174|Actinobacteria,4D8U5@85008|Micromonosporales	201174|Actinobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
TLS2_k127_3953214_46	1121946.AUAX01000005_gene5268	1.139e-68	239.0	COG0200@1|root,COG0200@2|Bacteria,2II6M@201174|Actinobacteria,4DCN5@85008|Micromonosporales	201174|Actinobacteria	J	Binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
TLS2_k127_3953214_77	263358.VAB18032_01070	1.891e-24	103.0	COG1841@1|root,COG1841@2|Bacteria,2GQV0@201174|Actinobacteria,4DFYC@85008|Micromonosporales	201174|Actinobacteria	J	Ribosomal protein L30	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
TLS2_k127_3953214_32	33876.JNXY01000022_gene4517	3.922e-98	326.0	COG0098@1|root,COG0098@2|Bacteria,2GJW8@201174|Actinobacteria,4D9MJ@85008|Micromonosporales	201174|Actinobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
TLS2_k127_3953214_61	369723.Strop_3907	4.518e-48	175.0	COG0256@1|root,COG0256@2|Bacteria,2IKTX@201174|Actinobacteria,4DDMM@85008|Micromonosporales	201174|Actinobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0008150,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
TLS2_k127_3953214_33	263358.VAB18032_01085	2.18e-95	314.0	COG0097@1|root,COG0097@2|Bacteria,2GK35@201174|Actinobacteria,4DAXG@85008|Micromonosporales	201174|Actinobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
TLS2_k127_3953214_44	1120949.KB903309_gene1057	1.508e-70	241.0	COG0096@1|root,COG0096@2|Bacteria,2IHQZ@201174|Actinobacteria,4DCU8@85008|Micromonosporales	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
TLS2_k127_3953214_72	1206743.BAGM01000196_gene966	2.67e-29	121.0	COG0199@1|root,COG0199@2|Bacteria,2IQ8R@201174|Actinobacteria,4G30T@85025|Nocardiaceae	201174|Actinobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
TLS2_k127_3953214_31	263358.VAB18032_01100	8.612e-101	331.0	COG0094@1|root,COG0094@2|Bacteria,2GJW7@201174|Actinobacteria,4D8NK@85008|Micromonosporales	201174|Actinobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
TLS2_k127_3953214_66	33876.JNXY01000022_gene4523	1.907e-43	162.0	COG0198@1|root,COG0198@2|Bacteria,2IKP2@201174|Actinobacteria,4DEDA@85008|Micromonosporales	201174|Actinobacteria	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
TLS2_k127_3953214_47	219305.MCAG_02077	5.438e-68	231.0	COG0093@1|root,COG0093@2|Bacteria,2IHNX@201174|Actinobacteria,4DDMH@85008|Micromonosporales	201174|Actinobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
TLS2_k127_3953214_68	1210045.ALNP01000008_gene4525	2.824e-40	150.0	COG0186@1|root,COG0186@2|Bacteria,2IQ68@201174|Actinobacteria	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
TLS2_k127_3953214_71	649831.L083_0932	2.688e-31	125.0	COG0255@1|root,COG0255@2|Bacteria,2IQ6V@201174|Actinobacteria,4DEXA@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
TLS2_k127_3953214_37	446470.Snas_1192	3.277e-84	279.0	COG0197@1|root,COG0197@2|Bacteria,2IFEI@201174|Actinobacteria,4EYGG@85014|Glycomycetales	201174|Actinobacteria	J	Ribosomal protein L16p/L10e	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
TLS2_k127_3953214_18	33876.JNXY01000022_gene4528	5.005e-136	439.0	COG0092@1|root,COG0092@2|Bacteria,2GKF1@201174|Actinobacteria,4D91J@85008|Micromonosporales	201174|Actinobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
TLS2_k127_3953214_58	1121272.KB903250_gene3001	1.128e-50	188.0	COG0091@1|root,COG0091@2|Bacteria,2IM3J@201174|Actinobacteria,4DD68@85008|Micromonosporales	201174|Actinobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
TLS2_k127_3953214_60	390989.JOEG01000009_gene1209	1.67e-49	179.0	COG0185@1|root,COG0185@2|Bacteria,2IKMS@201174|Actinobacteria,4DE0E@85008|Micromonosporales	201174|Actinobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
TLS2_k127_3953214_15	1121946.AUAX01000005_gene5252	2.196e-163	517.0	COG0090@1|root,COG0090@2|Bacteria,2GK7R@201174|Actinobacteria,4DAJD@85008|Micromonosporales	201174|Actinobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
TLS2_k127_3953214_59	512565.AMIS_6050	1.045e-49	179.0	COG0089@1|root,COG0089@2|Bacteria,2IQ7V@201174|Actinobacteria,4DE5U@85008|Micromonosporales	201174|Actinobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
TLS2_k127_3953214_34	369723.Strop_3922	1.715e-90	305.0	COG0088@1|root,COG0088@2|Bacteria,2GJYJ@201174|Actinobacteria,4DARE@85008|Micromonosporales	201174|Actinobacteria	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
TLS2_k127_3953214_29	134676.ACPL_782	3.741e-110	359.0	COG0087@1|root,COG0087@2|Bacteria,2GJXT@201174|Actinobacteria,4D8ZT@85008|Micromonosporales	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
TLS2_k127_3953214_50	543632.JOJL01000008_gene5717	2.412e-59	206.0	COG0051@1|root,COG0051@2|Bacteria,2IHRA@201174|Actinobacteria,4DDDS@85008|Micromonosporales	201174|Actinobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
TLS2_k127_3953214_6	644283.Micau_5529	9.535e-234	728.0	COG0050@1|root,COG0050@2|Bacteria,2GK4T@201174|Actinobacteria,4DBW2@85008|Micromonosporales	201174|Actinobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0019899,GO:0030312,GO:0035375,GO:0036293,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TLS2_k127_3953214_1	391037.Sare_4318	0.0	1249.0	COG0480@1|root,COG0480@2|Bacteria,2GKB3@201174|Actinobacteria,4DAJC@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_3953214_36	644283.Micau_5531	3.075e-85	284.0	COG0049@1|root,COG0049@2|Bacteria,2GMVW@201174|Actinobacteria,4D8XV@85008|Micromonosporales	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
TLS2_k127_3953214_48	1869.MB27_32540	4.621e-67	233.0	COG0048@1|root,COG0048@2|Bacteria,2IHUF@201174|Actinobacteria,4DDX0@85008|Micromonosporales	201174|Actinobacteria	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
TLS2_k127_3953214_79	1121946.AUAX01000005_gene5243	3.363e-18	91.0	294U6@1|root,2ZS7C@2|Bacteria,2IREJ@201174|Actinobacteria,4DF80@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
TLS2_k127_3953214_74	219305.MCAG_02094	5.205e-28	117.0	28UMC@1|root,2ZGRW@2|Bacteria,2IM7H@201174|Actinobacteria,4DE70@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3953214_0	35754.JNYJ01000004_gene5985	0.0	1568.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4DA6K@85008|Micromonosporales	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
TLS2_k127_3981156_9	1449976.KALB_2277	1.938e-87	291.0	COG0491@1|root,COG0491@2|Bacteria,2HJB4@201174|Actinobacteria,4E04N@85010|Pseudonocardiales	201174|Actinobacteria	S	Zn-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_3981156_12	369723.Strop_1204	2.088e-27	117.0	2AYJ3@1|root,31IGV@2|Bacteria,2IHZW@201174|Actinobacteria,4DDCK@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3981156_1	1246995.AFR_28360	2.885e-222	696.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4D966@85008|Micromonosporales	201174|Actinobacteria	C	Dehydrogenase	gabD1	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_3981156_5	1120949.KB903339_gene8050	3.225e-126	418.0	COG4826@1|root,COG4826@2|Bacteria,2GJ5T@201174|Actinobacteria,4DF6M@85008|Micromonosporales	201174|Actinobacteria	O	SERine  Proteinase INhibitors	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
TLS2_k127_3981156_13	1121946.AUAX01000014_gene1230	1.376e-10	72.0	2BHJC@1|root,32BMT@2|Bacteria,2IQWW@201174|Actinobacteria,4DETD@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3981156_11	402881.Plav_0855	9.977e-55	200.0	COG0702@1|root,COG0702@2|Bacteria,1MZG7@1224|Proteobacteria,2UBX1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	Nucleoside-diphosphate-sugar epimerases	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
TLS2_k127_3981156_7	1157637.KB892100_gene2385	1.018e-101	344.0	COG0477@1|root,COG2814@2|Bacteria,2HRV9@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_3981156_8	1463821.JOGR01000008_gene2017	2.329e-91	327.0	2BDD1@1|root,3271X@2|Bacteria,2IFV9@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3981156_0	479432.Sros_2137	0.0	2010.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4EFW6@85012|Streptosporangiales	201174|Actinobacteria	E	B12 binding domain	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TLS2_k127_3981156_6	1206729.BAFZ01000007_gene1308	4.092e-110	364.0	COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria,4FX0U@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
TLS2_k127_3981156_10	33876.JNXY01000005_gene8577	1.155e-58	211.0	2AZDP@1|root,31RMA@2|Bacteria,2GUFH@201174|Actinobacteria,4DCA2@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF4230)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4230
TLS2_k127_3981156_2	1246995.AFR_41775	7.722e-171	541.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4DB3I@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS2_k127_3981156_3	1869.MB27_38515	4.308e-159	521.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4D8DM@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_3981156_4	2002.JOEQ01000002_gene4423	1.141e-158	506.0	COG0601@1|root,COG0601@2|Bacteria,2GK0Z@201174|Actinobacteria,4EFUB@85012|Streptosporangiales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_4000775_3	263358.VAB18032_29671	4.863e-152	482.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4D9K3@85008|Micromonosporales	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
TLS2_k127_4000775_20	350058.Mvan_2981	1.564e-17	93.0	COG2346@1|root,COG2346@2|Bacteria,2GQFN@201174|Actinobacteria,2397P@1762|Mycobacteriaceae	201174|Actinobacteria	C	Group 1 truncated hemoglobin	glbN	GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008941,GO:0009056,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016491,GO:0016705,GO:0016708,GO:0017144,GO:0019825,GO:0020012,GO:0020037,GO:0030682,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042737,GO:0043207,GO:0044237,GO:0044248,GO:0044270,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046209,GO:0046210,GO:0046906,GO:0048037,GO:0050896,GO:0051213,GO:0051410,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0072593,GO:0075136,GO:0097159,GO:0098754,GO:1901363,GO:1901698,GO:2001057	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
TLS2_k127_4000775_13	263358.VAB18032_13020	5.058e-66	231.0	COG1576@1|root,COG1576@2|Bacteria,2IGAN@201174|Actinobacteria,4DFNX@85008|Micromonosporales	201174|Actinobacteria	J	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS2_k127_4000775_15	391037.Sare_4027	2.811e-33	136.0	COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4DEXG@85008|Micromonosporales	201174|Actinobacteria	J	Binds the 23S rRNA	rpmE	GO:0008150,GO:0040007	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
TLS2_k127_4000775_2	263358.VAB18032_29661	7.615e-180	569.0	COG0216@1|root,COG0216@2|Bacteria,2GJWG@201174|Actinobacteria,4D9GD@85008|Micromonosporales	201174|Actinobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	GO:0008150,GO:0040007	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS2_k127_4000775_4	1150864.MILUP08_45928	1.077e-148	493.0	COG2199@1|root,COG2199@2|Bacteria,2I97W@201174|Actinobacteria,4D904@85008|Micromonosporales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
TLS2_k127_4000775_8	1150864.MILUP08_45927	1.395e-92	312.0	COG2890@1|root,COG2890@2|Bacteria,2GMH1@201174|Actinobacteria,4DBJC@85008|Micromonosporales	201174|Actinobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
TLS2_k127_4000775_10	1150864.MILUP08_45926	1.107e-83	282.0	COG0009@1|root,COG0009@2|Bacteria,2GK2X@201174|Actinobacteria,4D9KF@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the SUA5 family	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
TLS2_k127_4000775_12	391037.Sare_4022	4.312e-74	265.0	COG0394@1|root,COG0394@2|Bacteria,2GMPR@201174|Actinobacteria,4DCYK@85008|Micromonosporales	201174|Actinobacteria	T	Low molecular weight phosphotyrosine protein phosphatase	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS2_k127_4000775_14	479432.Sros_8570	1.428e-56	199.0	COG5015@1|root,COG5015@2|Bacteria,2I3I5@201174|Actinobacteria,4EJIN@85012|Streptosporangiales	201174|Actinobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_4000775_16	391037.Sare_4020	1.854e-32	133.0	2DSZR@1|root,33I3C@2|Bacteria,2GR0C@201174|Actinobacteria,4DG07@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4000775_18	219305.MCAG_01749	1.867e-22	98.0	COG5336@1|root,COG5336@2|Bacteria,2HUPU@201174|Actinobacteria,4DFQK@85008|Micromonosporales	201174|Actinobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	-	-	-	-	-	-	-	-	-	ATPase_gene1
TLS2_k127_4000775_7	391037.Sare_4018	6.7e-110	361.0	COG0356@1|root,COG0356@2|Bacteria,2H3PR@201174|Actinobacteria,4DAVG@85008|Micromonosporales	201174|Actinobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
TLS2_k127_4000775_17	219305.MCAG_01747	4.427e-32	125.0	COG0636@1|root,COG0636@2|Bacteria,2GQI6@201174|Actinobacteria,4DFMN@85008|Micromonosporales	201174|Actinobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
TLS2_k127_4000775_11	356851.JOAN01000006_gene231	2.99e-75	256.0	COG0711@1|root,COG0711@2|Bacteria,2GJS4@201174|Actinobacteria,4DCTW@85008|Micromonosporales	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
TLS2_k127_4000775_9	644283.Micau_5134	3.912e-87	298.0	COG0712@1|root,COG0712@2|Bacteria,2GMJ5@201174|Actinobacteria,4DA09@85008|Micromonosporales	201174|Actinobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02109,ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
TLS2_k127_4000775_0	644283.Micau_5133	4.22e-280	868.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4D90M@85008|Micromonosporales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
TLS2_k127_4000775_5	369723.Strop_3631	3.536e-132	427.0	COG0224@1|root,COG0224@2|Bacteria,2GJ7Q@201174|Actinobacteria,4D8FX@85008|Micromonosporales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
TLS2_k127_4000775_1	219305.MCAG_01742	7.152e-266	823.0	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4DC7V@85008|Micromonosporales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS2_k127_4000775_6	219305.MCAG_01741	1.073e-126	416.0	COG1316@1|root,COG1316@2|Bacteria,2I9WG@201174|Actinobacteria,4D8UT@85008|Micromonosporales	201174|Actinobacteria	K	cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
TLS2_k127_4000775_19	1121946.AUAX01000008_gene7235	3.167e-18	90.0	COG3667@1|root,COG3667@2|Bacteria,2IHUC@201174|Actinobacteria,4DDBI@85008|Micromonosporales	201174|Actinobacteria	P	copper resistance	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4012856_4	219305.MCAG_04663	7.257e-112	391.0	COG1887@1|root,COG1887@2|Bacteria,2H6EP@201174|Actinobacteria,4DBXE@85008|Micromonosporales	201174|Actinobacteria	M	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyphos_transf
TLS2_k127_4012856_8	1464048.JNZS01000004_gene1657	3.403e-87	296.0	COG1682@1|root,COG1682@2|Bacteria,2GP5K@201174|Actinobacteria,4DBAH@85008|Micromonosporales	201174|Actinobacteria	GM	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_4012856_6	1121946.AUAX01000005_gene5194	7.107e-101	345.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4D8V5@85008|Micromonosporales	201174|Actinobacteria	GM	ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,Wzt_C
TLS2_k127_4012856_20	1385520.N802_07670	6.033e-22	102.0	2EA9M@1|root,334E1@2|Bacteria,2I49S@201174|Actinobacteria	201174|Actinobacteria	S	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
TLS2_k127_4012856_14	1123065.ATWL01000014_gene3502	2.008e-62	224.0	COG1794@1|root,COG1794@2|Bacteria,2H7J9@201174|Actinobacteria	201174|Actinobacteria	M	aspartate racemase	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
TLS2_k127_4012856_5	1123065.ATWL01000014_gene3499	9.182e-111	387.0	COG0189@1|root,COG0189@2|Bacteria,2GN0U@201174|Actinobacteria	201174|Actinobacteria	HJ	Belongs to the MurCDEF family	-	-	-	-	-	-	-	-	-	-	-	-	CPSase_L_D2,GARS_A
TLS2_k127_4012856_1	1123065.ATWL01000014_gene3503	1.472e-184	598.0	COG0189@1|root,COG1254@1|root,COG0189@2|Bacteria,COG1254@2|Bacteria,2GN0U@201174|Actinobacteria	201174|Actinobacteria	HJ	Belongs to the MurCDEF family	-	-	-	-	-	-	-	-	-	-	-	-	Acylphosphatase,CPSase_L_D2
TLS2_k127_4012856_16	1123065.ATWL01000014_gene3504	1.024e-51	200.0	2DY46@1|root,3482H@2|Bacteria,2H8A9@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4012856_9	96561.Dole_2679	1.634e-74	264.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,42T4H@68525|delta/epsilon subdivisions,2X5J5@28221|Deltaproteobacteria,2MPF5@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	6.3.2.10	ko:K01929,ko:K07282	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	PGA_cap
TLS2_k127_4012856_10	1122602.ATXP01000013_gene1306	6.472e-73	258.0	COG0189@1|root,COG0189@2|Bacteria,2GN0U@201174|Actinobacteria	201174|Actinobacteria	HJ	Belongs to the MurCDEF family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4012856_17	1033736.CAHK01000012_gene2189	1.16e-48	195.0	COG0189@1|root,COG0189@2|Bacteria,2GN0U@201174|Actinobacteria	201174|Actinobacteria	HJ	Belongs to the MurCDEF family	-	-	-	-	-	-	-	-	-	-	-	-	Acylphosphatase,CPSase_L_D2,GARS_A
TLS2_k127_4012856_7	164757.Mjls_5050	4.182e-95	324.0	COG0189@1|root,COG0189@2|Bacteria,2IJUJ@201174|Actinobacteria	201174|Actinobacteria	HJ	TupA-like ATPgrasp	-	-	-	-	-	-	-	-	-	-	-	-	ATPgrasp_TupA
TLS2_k127_4012856_19	1033736.CAHK01000012_gene2189	1.355e-37	163.0	COG0189@1|root,COG0189@2|Bacteria,2GN0U@201174|Actinobacteria	201174|Actinobacteria	HJ	Belongs to the MurCDEF family	-	-	-	-	-	-	-	-	-	-	-	-	Acylphosphatase,CPSase_L_D2,GARS_A
TLS2_k127_4012856_0	1122611.KB903994_gene7392	2.136e-185	589.0	COG1509@1|root,COG1509@2|Bacteria,2GM2P@201174|Actinobacteria,4EI4J@85012|Streptosporangiales	201174|Actinobacteria	E	lysine 2,3-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4012856_13	1123065.ATWL01000014_gene3503	1.821e-65	255.0	COG0189@1|root,COG1254@1|root,COG0189@2|Bacteria,COG1254@2|Bacteria,2GN0U@201174|Actinobacteria	201174|Actinobacteria	HJ	Belongs to the MurCDEF family	-	-	-	-	-	-	-	-	-	-	-	-	Acylphosphatase,CPSase_L_D2
TLS2_k127_4012856_12	1304275.C41B8_00915	1.156e-68	251.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	ATPgrasp_ST,RimK
TLS2_k127_4012856_15	1304275.C41B8_00915	4.82e-57	220.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	ATPgrasp_ST,RimK
TLS2_k127_4012856_18	1121289.JHVL01000084_gene1571	1.575e-39	151.0	COG0615@1|root,COG0615@2|Bacteria,1V3KY@1239|Firmicutes,24HAQ@186801|Clostridia,36M3N@31979|Clostridiaceae	186801|Clostridia	IM	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
TLS2_k127_4012856_3	1122138.AQUZ01000017_gene6565	9.262e-114	379.0	COG0451@1|root,COG0451@2|Bacteria,2I2SW@201174|Actinobacteria,4DTDB@85009|Propionibacteriales	201174|Actinobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
TLS2_k127_4012856_11	100226.SCO6023	3.511e-71	271.0	COG0438@1|root,COG0438@2|Bacteria,2GJBP@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Stealth_CR1,Stealth_CR2,Stealth_CR3,Stealth_CR4
TLS2_k127_4012856_2	1463821.JOGR01000003_gene1117	4.07e-118	392.0	COG1454@1|root,COG1454@2|Bacteria,2I2FD@201174|Actinobacteria,4EZBS@85014|Glycomycetales	201174|Actinobacteria	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
TLS2_k127_403262_1	134676.ACPL_7654	5.465e-252	786.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4D95Q@85008|Micromonosporales	201174|Actinobacteria	C	succinate dehydrogenase	sdhA2	-	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_403262_6	1150864.MILUP08_46122	4.886e-130	422.0	2CEY7@1|root,2Z8CG@2|Bacteria,2GKI0@201174|Actinobacteria,4DA15@85008|Micromonosporales	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_403262_4	649831.L083_7375	6.491e-145	475.0	COG0312@1|root,COG0312@2|Bacteria,2GZPS@201174|Actinobacteria,4D8XK@85008|Micromonosporales	201174|Actinobacteria	S	peptidase U62, modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
TLS2_k127_403262_0	644283.Micau_5331	3.24e-262	814.0	COG0312@1|root,COG0312@2|Bacteria,2GJ4E@201174|Actinobacteria,4DBR6@85008|Micromonosporales	201174|Actinobacteria	S	peptidase U62, modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS2_k127_403262_2	1136417.AZWE01000001_gene3837	4.044e-212	679.0	COG1506@1|root,COG1506@2|Bacteria,2GJ6A@201174|Actinobacteria,4D8DW@85008|Micromonosporales	201174|Actinobacteria	E	peptidase S9B dipeptidylpeptidase IV domain protein	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
TLS2_k127_403262_5	219305.MCAG_01917	1.087e-131	428.0	COG2120@1|root,COG2120@2|Bacteria,2GKUM@201174|Actinobacteria,4D9RF@85008|Micromonosporales	201174|Actinobacteria	S	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway	mshB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016020,GO:0016137,GO:0016138,GO:0016787,GO:0016810,GO:0016811,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	3.5.1.103	ko:K15525	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_403262_14	1464048.JNZS01000031_gene2942	1.168e-12	77.0	2AY9G@1|root,31QBT@2|Bacteria,2IRW9@201174|Actinobacteria,4DEV4@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_403262_3	263358.VAB18032_03450	3.095e-179	578.0	COG2720@1|root,COG2720@2|Bacteria,2GISH@201174|Actinobacteria,4DBHR@85008|Micromonosporales	201174|Actinobacteria	V	VanW family	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
TLS2_k127_403262_12	1121946.AUAX01000005_gene5468	1.102e-22	105.0	28SGT@1|root,2ZET7@2|Bacteria,2IP7N@201174|Actinobacteria,4DEBG@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_403262_7	1869.MB27_02035	1.861e-124	403.0	COG0005@1|root,COG0005@2|Bacteria,2GKGG@201174|Actinobacteria,4DA0V@85008|Micromonosporales	201174|Actinobacteria	F	Purine nucleoside phosphorylase involved in purine salvage	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_403262_8	512565.AMIS_8970	5.972e-80	272.0	COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria,4DBT1@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the UPF0301 (AlgH) family	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
TLS2_k127_403262_16	1146883.BLASA_1078	7.138e-05	47.0	COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria,4ESQP@85013|Frankiales	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	int	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
TLS2_k127_403262_11	211114.JOEF01000022_gene5635	2.271e-36	143.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_403262_15	879308.HMPREF9130_1593	8.01e-08	61.0	28KKS@1|root,2ZA5I@2|Bacteria,1V11Y@1239|Firmicutes,24EK5@186801|Clostridia,22HIU@1570339|Peptoniphilaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_403262_13	345341.KUTG_04083	5.419e-20	100.0	COG0845@1|root,COG0845@2|Bacteria,2IFY7@201174|Actinobacteria,4E0I4@85010|Pseudonocardiales	201174|Actinobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
TLS2_k127_403262_10	471856.Jden_0218	1.233e-73	256.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_403262_9	471856.Jden_0219	5.024e-74	265.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_4117516_7	644283.Micau_2880	8.284e-114	372.0	COG0715@1|root,COG0715@2|Bacteria,2GN9B@201174|Actinobacteria,4DBTW@85008|Micromonosporales	201174|Actinobacteria	P	Protein of unknown function (DUF3500)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3500
TLS2_k127_4117516_0	35754.JNYJ01000030_gene7556	1.837e-247	786.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,4DBTA@85008|Micromonosporales	201174|Actinobacteria	L	UvrD-like helicase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD-helicase,UvrD_C_2
TLS2_k127_4117516_25	1121946.AUAX01000007_gene2706	6.376e-17	89.0	2BDNC@1|root,327BT@2|Bacteria,2HD04@201174|Actinobacteria,4DKD0@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4117516_8	35754.JNYJ01000030_gene7558	8.127e-102	340.0	COG1192@1|root,COG1192@2|Bacteria,2IFZ7@201174|Actinobacteria,4DDJX@85008|Micromonosporales	201174|Actinobacteria	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS2_k127_4117516_5	219305.MCAG_04077	3.259e-121	396.0	28KEA@1|root,2ZA0J@2|Bacteria,2I9YN@201174|Actinobacteria,4DCRZ@85008|Micromonosporales	201174|Actinobacteria	H	Sulfotransferase domain	-	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006790,GO:0008146,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016782,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044272,GO:0044281,GO:0046505,GO:0046506,GO:0071704,GO:1901576	2.8.2.1	ko:K01014	ko05204,map05204	-	R01242	RC00007,RC00128	ko00000,ko00001,ko01000	-	-	-	Sulfotransfer_1
TLS2_k127_4117516_26	1150864.MILUP08_45660	1.828e-05	56.0	2B59W@1|root,31Y41@2|Bacteria,2H06C@201174|Actinobacteria,4DGIW@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4117516_24	1121946.AUAX01000001_gene2425	3.634e-21	97.0	2C1FX@1|root,3358G@2|Bacteria,2GS1S@201174|Actinobacteria,4DFJ2@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4117516_13	446471.Xcel_3106	4.16e-74	269.0	COG3509@1|root,COG3509@2|Bacteria,2GNV6@201174|Actinobacteria,4F5XQ@85017|Promicromonosporaceae	201174|Actinobacteria	Q	Esterase PHB depolymerase	lpqC	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase_phd
TLS2_k127_4117516_21	1089551.KE386572_gene3873	2.604e-36	155.0	COG1028@1|root,COG1028@2|Bacteria,1MX8B@1224|Proteobacteria,2U26N@28211|Alphaproteobacteria,4BS22@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	MA20_18145	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_4117516_4	100226.SCO0366	1.048e-134	437.0	COG2017@1|root,COG2017@2|Bacteria,2IDCU@201174|Actinobacteria	201174|Actinobacteria	G	Domain of unknown function (DUF4432)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4432
TLS2_k127_4117516_2	1463820.JOGW01000008_gene1306	8.359e-198	643.0	COG3459@1|root,COG3459@2|Bacteria	2|Bacteria	G	carbohydrate binding	-	-	2.4.1.20	ko:K00702	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000	-	GT36	-	Glyco_hydro_36,Glyco_transf_36
TLS2_k127_4117516_17	312284.A20C1_08363	4.048e-60	225.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_4117516_11	312284.A20C1_08373	6.934e-86	295.0	COG1175@1|root,COG1175@2|Bacteria,2I8Y3@201174|Actinobacteria	201174|Actinobacteria	P	inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_4117516_22	67257.JODR01000014_gene5619	1.485e-31	136.0	COG0395@1|root,COG0395@2|Bacteria,2GJNN@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
TLS2_k127_4117516_16	742159.HMPREF0004_0143	1.932e-62	223.0	COG1028@1|root,COG1028@2|Bacteria,1MXVZ@1224|Proteobacteria,2VMQ5@28216|Betaproteobacteria,3T1C4@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_4117516_18	266117.Rxyl_0531	2.45e-49	193.0	COG1028@1|root,COG1028@2|Bacteria,2HP88@201174|Actinobacteria,4CT17@84995|Rubrobacteria	84995|Rubrobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_4117516_9	266117.Rxyl_0532	1.152e-95	325.0	COG2017@1|root,COG2017@2|Bacteria,2IDCU@201174|Actinobacteria	201174|Actinobacteria	G	Domain of unknown function (DUF4432)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4432
TLS2_k127_4117516_12	1122132.AQYH01000006_gene3653	1.182e-85	290.0	COG4689@1|root,COG4689@2|Bacteria,1N4IP@1224|Proteobacteria,2TTZX@28211|Alphaproteobacteria,4BBTX@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Acetoacetate decarboxylase (ADC)	-	-	4.1.1.4	ko:K01574	ko00072,ko00640,ko01100,map00072,map00640,map01100	M00088	R01366	RC00040	ko00000,ko00001,ko00002,ko01000	-	-	-	ADC
TLS2_k127_4117516_15	266940.Krad_0199	1.964e-64	233.0	COG1052@1|root,COG1052@2|Bacteria,2I2RK@201174|Actinobacteria	201174|Actinobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_4117516_14	1317118.ATO8_16765	9.89e-66	238.0	COG4948@1|root,COG4948@2|Bacteria,1R85F@1224|Proteobacteria,2V87S@28211|Alphaproteobacteria,4KNE9@93682|Roseivivax	28211|Alphaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_4117516_19	66373.JOFQ01000005_gene3738	5.085e-45	177.0	COG1609@1|root,COG1609@2|Bacteria,2GNVD@201174|Actinobacteria	201174|Actinobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
TLS2_k127_4117516_3	1416752.AYME01000008_gene3393	2.47e-162	522.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,4FKJV@85023|Microbacteriaceae	201174|Actinobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TLS2_k127_4117516_10	1416752.AYME01000008_gene3392	9.998e-87	301.0	COG0510@1|root,COG0510@2|Bacteria	2|Bacteria	M	ethanolamine kinase activity	-	-	2.7.1.89	ko:K07251	ko00730,ko01100,map00730,map01100	-	R02134	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	APH,Choline_kinase
TLS2_k127_4117516_6	1416752.AYME01000008_gene3390	7.667e-118	387.0	COG0179@1|root,COG0179@2|Bacteria,2GKED@201174|Actinobacteria,4FN0Y@85023|Microbacteriaceae	201174|Actinobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
TLS2_k127_4117516_1	1122611.KB903941_gene2162	1.802e-237	744.0	COG1012@1|root,COG1012@2|Bacteria,2GT45@201174|Actinobacteria,4EI61@85012|Streptosporangiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS2_k127_4117516_23	457429.ABJI02000778_gene1331	1.674e-28	124.0	COG0515@1|root,COG0515@2|Bacteria,2GJQN@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4131748_7	1206101.AZXC01000056_gene5541	7.276e-11	64.0	COG1020@1|root,COG1020@2|Bacteria,2GRRE@201174|Actinobacteria	201174|Actinobacteria	Q	Condensation domain	-	-	-	ko:K21186	ko01059,map01059	-	-	-	ko00000,ko00001	-	-	-	AMP-binding,Condensation
TLS2_k127_4131748_1	479432.Sros_6983	3.441e-212	666.0	COG2124@1|root,COG2124@2|Bacteria,2GJ30@201174|Actinobacteria,4EGJP@85012|Streptosporangiales	201174|Actinobacteria	Q	Cytochrome P450	-	-	1.14.99.49	ko:K20420	ko01059,ko01130,map01059,map01130	M00830	R10796	RC00490	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N,p450
TLS2_k127_4131748_5	405948.SACE_1244	1.989e-85	288.0	COG1733@1|root,COG1733@2|Bacteria,2GMK5@201174|Actinobacteria,4E5A4@85010|Pseudonocardiales	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS2_k127_4131748_0	1120949.KB903339_gene7999	4.255e-224	716.0	COG2409@1|root,COG2409@2|Bacteria,2GIRQ@201174|Actinobacteria,4DAF8@85008|Micromonosporales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_4131748_3	479432.Sros_6974	7.352e-189	598.0	COG1960@1|root,COG1960@2|Bacteria,2GMKM@201174|Actinobacteria,4EH3T@85012|Streptosporangiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
TLS2_k127_4131748_6	1206101.AZXC01000056_gene5537	1.989e-47	175.0	COG4319@1|root,COG4319@2|Bacteria,2IMHY@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_2,SnoaL_3
TLS2_k127_4131748_2	1179773.BN6_38970	3.007e-197	624.0	COG0654@1|root,COG0654@2|Bacteria,2GK7I@201174|Actinobacteria,4DXC9@85010|Pseudonocardiales	201174|Actinobacteria	CH	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,FAD_binding_2,FAD_binding_3,FAD_oxidored
TLS2_k127_4131748_4	1068980.ARVW01000001_gene4911	1.694e-184	593.0	COG1020@1|root,COG1020@2|Bacteria,2GN2N@201174|Actinobacteria,4E8FT@85010|Pseudonocardiales	201174|Actinobacteria	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,PP-binding
TLS2_k127_4151085_0	263358.VAB18032_18980	0.0	1302.0	COG3291@1|root,COG3291@2|Bacteria,2I5PU@201174|Actinobacteria,4DMPN@85008|Micromonosporales	201174|Actinobacteria	M	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PA,Peptidase_M36
TLS2_k127_4151085_8	208439.AJAP_05440	1.44e-110	367.0	COG0024@1|root,COG0024@2|Bacteria,2GKKB@201174|Actinobacteria,4DY9S@85010|Pseudonocardiales	201174|Actinobacteria	E	methionine	map_2	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS2_k127_4151085_14	926564.KI911760_gene4954	9.174e-51	186.0	COG0666@1|root,COG0666@2|Bacteria,2I3AT@201174|Actinobacteria,4F52A@85017|Promicromonosporaceae	201174|Actinobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_4151085_3	222534.KB893738_gene1273	1.877e-192	609.0	COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria,4ES3N@85013|Frankiales	201174|Actinobacteria	C	PFAM FMN-dependent alpha-hydroxy acid dehydrogenase	lldD	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	1.1.2.3,1.1.3.15	ko:K00101,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00196,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	iNJ661.Rv1872c	FMN_dh
TLS2_k127_4151085_2	35754.JNYJ01000023_gene8321	5.286e-202	666.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4D9E2@85008|Micromonosporales	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,HTH_31,NB-ARC,TPR_10,TPR_12,TPR_8,Trans_reg_C
TLS2_k127_4151085_9	1227352.C173_12015	1.164e-99	361.0	2BWG8@1|root,2Z8GJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4151085_13	644283.Micau_4936	9.472e-66	227.0	COG0251@1|root,COG0251@2|Bacteria,2IHT4@201174|Actinobacteria,4DDZV@85008|Micromonosporales	201174|Actinobacteria	J	endoribonuclease L-PSP	-	-	3.5.99.5	ko:K15067	ko00380,map00380	-	R03887	RC01015	ko00000,ko00001,ko01000	-	-	-	Ribonuc_L-PSP
TLS2_k127_4151085_4	1449347.JQLN01000006_gene2828	7.285e-180	567.0	COG0119@1|root,COG0119@2|Bacteria,2GJBI@201174|Actinobacteria,2M33Z@2063|Kitasatospora	201174|Actinobacteria	E	DmpG-like communication domain	-	-	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	DmpG_comm,HMGL-like
TLS2_k127_4151085_5	644283.Micau_4939	4.846e-137	441.0	COG4569@1|root,COG4569@2|Bacteria,2GKBZ@201174|Actinobacteria,4DC7P@85008|Micromonosporales	201174|Actinobacteria	Q	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds	-	-	1.2.1.10	ko:K04073	ko00360,ko00362,ko00620,ko00621,ko00622,ko00650,ko01100,ko01120,ko01220,map00360,map00362,map00620,map00621,map00622,map00650,map01100,map01120,map01220	M00545,M00569	R00228,R01172	RC00004,RC00184,RC01195	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	AcetDehyd-dimer,Semialdhyde_dh
TLS2_k127_4151085_20	356851.JOAN01000022_gene2230	2.642e-12	78.0	COG3416@1|root,COG3416@2|Bacteria,2HVVA@201174|Actinobacteria,4DEHY@85008|Micromonosporales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS2_k127_4151085_17	644283.Micau_2760	2.555e-32	143.0	COG3416@1|root,COG3416@2|Bacteria,2HVVA@201174|Actinobacteria,4DEHY@85008|Micromonosporales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS2_k127_4151085_15	1385521.N803_16145	5.028e-49	180.0	COG1595@1|root,COG1595@2|Bacteria,2GP2X@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_4151085_7	1504981.KO116_1495	1.97e-115	377.0	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,1RPWM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phenazine biosynthesis protein PhzF	pab	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
TLS2_k127_4151085_16	35754.JNYJ01000001_gene7509	8.88e-39	153.0	COG0739@1|root,COG0739@2|Bacteria,2IMHS@201174|Actinobacteria,4DM08@85008|Micromonosporales	201174|Actinobacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4151085_6	471853.Bcav_2280	2.472e-127	438.0	COG1595@1|root,COG1595@2|Bacteria,2GK2Y@201174|Actinobacteria	201174|Actinobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_3
TLS2_k127_4151085_11	479432.Sros_2428	1.009e-79	274.0	COG3208@1|root,COG3208@2|Bacteria,2HF6C@201174|Actinobacteria,4EP44@85012|Streptosporangiales	201174|Actinobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioesterase
TLS2_k127_4151085_1	1120950.KB892746_gene3457	3.915e-211	663.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4DP3H@85009|Propionibacteriales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4151085_12	1120950.KB892746_gene3456	3.988e-74	250.0	COG3795@1|root,COG3795@2|Bacteria,2IFD6@201174|Actinobacteria,4DQYK@85009|Propionibacteriales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_4151085_10	543632.JOJL01000005_gene4824	4.081e-97	327.0	COG0406@1|root,COG0406@2|Bacteria,2GKY6@201174|Actinobacteria,4DEY8@85008|Micromonosporales	201174|Actinobacteria	G	phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
TLS2_k127_4151085_22	1298863.AUEP01000003_gene2710	0.0008731	44.0	COG3173@1|root,COG3173@2|Bacteria,2GKUU@201174|Actinobacteria	201174|Actinobacteria	K	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_4151085_21	1298863.AUEP01000003_gene2710	0.0003133	43.0	COG3173@1|root,COG3173@2|Bacteria,2GKUU@201174|Actinobacteria	201174|Actinobacteria	K	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_4151085_18	1237500.ANBA01000008_gene263	3e-19	87.0	COG0346@1|root,COG0346@2|Bacteria,2IFMD@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4156916_11	644283.Micau_0076	8.987e-158	501.0	COG0119@1|root,COG0119@2|Bacteria,2GKTP@201174|Actinobacteria,4D9GF@85008|Micromonosporales	201174|Actinobacteria	E	HMGL-like	mvaB	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS2_k127_4156916_1	644283.Micau_0077	2.41e-278	861.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4DB7X@85008|Micromonosporales	201174|Actinobacteria	I	Carboxyl transferase domain	yngE	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
TLS2_k127_4156916_4	263358.VAB18032_04720	2.093e-206	648.0	COG1960@1|root,COG1960@2|Bacteria,2GMEM@201174|Actinobacteria,4DAR6@85008|Micromonosporales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE19	GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681	1.3.8.1,1.3.99.12	ko:K00248,ko:K11410	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_4156916_6	33876.JNXY01000025_gene5282	1.897e-191	627.0	COG1396@1|root,COG3903@1|root,COG1396@2|Bacteria,COG3903@2|Bacteria,2ICR5@201174|Actinobacteria,4D8VU@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,TPR_12
TLS2_k127_4156916_24	649831.L083_0039	2.547e-51	188.0	COG1846@1|root,COG1846@2|Bacteria,2IPBX@201174|Actinobacteria,4DCPX@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_4156916_2	644283.Micau_0082	5.25e-244	765.0	COG2170@1|root,COG2170@2|Bacteria,2GKCT@201174|Actinobacteria,4D91B@85008|Micromonosporales	201174|Actinobacteria	S	glutamate--cysteine ligase	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
TLS2_k127_4156916_22	644283.Micau_0083	1.631e-56	214.0	COG0477@1|root,COG0477@2|Bacteria,2IDEH@201174|Actinobacteria,4DC40@85008|Micromonosporales	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4156916_30	263358.VAB18032_04755	4.218e-17	91.0	COG2815@1|root,COG2815@2|Bacteria,2GRTM@201174|Actinobacteria,4DFN2@85008|Micromonosporales	201174|Actinobacteria	S	PASTA domain	-	-	-	-	-	-	-	-	-	-	-	-	PASTA
TLS2_k127_4156916_27	512565.AMIS_360	3.197e-30	125.0	2B0IB@1|root,31SVW@2|Bacteria,2GQ4N@201174|Actinobacteria,4DFVD@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4156916_28	263358.VAB18032_04780	2.407e-25	110.0	28UND@1|root,2ZGSX@2|Bacteria,2GRKA@201174|Actinobacteria,4DFIY@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4156916_14	369723.Strop_0040	1.791e-121	398.0	COG1922@1|root,COG1922@2|Bacteria,2ICDG@201174|Actinobacteria,4DB21@85008|Micromonosporales	201174|Actinobacteria	M	Belongs to the glycosyltransferase 26 family	rffM	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
TLS2_k127_4156916_5	644283.Micau_0093	7.99e-200	628.0	COG0451@1|root,COG0451@2|Bacteria,2GPN0@201174|Actinobacteria,4D9C5@85008|Micromonosporales	201174|Actinobacteria	M	Nad-dependent epimerase dehydratase	-	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	Epimerase
TLS2_k127_4156916_23	1150864.MILUP08_46597	9.905e-55	208.0	COG2202@1|root,COG2202@2|Bacteria,2I3YJ@201174|Actinobacteria,4DMFS@85008|Micromonosporales	201174|Actinobacteria	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4156916_8	356851.JOAN01000015_gene2618	7.108e-177	585.0	COG4251@1|root,COG4251@2|Bacteria,2I8DG@201174|Actinobacteria,4DAV8@85008|Micromonosporales	201174|Actinobacteria	T	Nitrate and nitrite sensing	cvnA4	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,NIT
TLS2_k127_4156916_21	644283.Micau_5763	8.577e-64	224.0	COG2018@1|root,COG2018@2|Bacteria,2IIFV@201174|Actinobacteria,4DDJC@85008|Micromonosporales	201174|Actinobacteria	S	distant relative of homeotic protein bithoraxoid	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
TLS2_k127_4156916_26	1464048.JNZS01000002_gene415	6.823e-35	141.0	COG1846@1|root,COG1846@2|Bacteria,2II00@201174|Actinobacteria,4DG37@85008|Micromonosporales	201174|Actinobacteria	K	Protein of unknown function (DUF742)	-	-	-	-	-	-	-	-	-	-	-	-	DUF742
TLS2_k127_4156916_18	219305.MCAG_02327	4.019e-87	292.0	COG2229@1|root,COG2229@2|Bacteria,2GR2B@201174|Actinobacteria,4DBN3@85008|Micromonosporales	201174|Actinobacteria	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
TLS2_k127_4156916_12	369723.Strop_0042	2.562e-136	438.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4DB9K@85008|Micromonosporales	201174|Actinobacteria	T	FHA domain	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
TLS2_k127_4156916_20	1464048.JNZS01000009_gene5858	1.245e-71	261.0	COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,4DCT7@85008|Micromonosporales	201174|Actinobacteria	T	FHA domain	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
TLS2_k127_4156916_9	644283.Micau_0096	6.488e-173	556.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4D9WK@85008|Micromonosporales	201174|Actinobacteria	T	protein phosphatase 2C domain protein	pstP	GO:0000287,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043392,GO:0043412,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0045936,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
TLS2_k127_4156916_7	1150864.MILUP08_40066	3.399e-191	608.0	COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,4D9PC@85008|Micromonosporales	201174|Actinobacteria	D	Belongs to the SEDS family	rodA	GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
TLS2_k127_4156916_10	644283.Micau_0098	3.695e-168	542.0	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,4D8HI@85008|Micromonosporales	201174|Actinobacteria	M	Peptidoglycan glycosyltransferase	pbpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
TLS2_k127_4156916_13	512565.AMIS_460	1.873e-127	420.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4D8PV@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_4156916_3	369723.Strop_0048	2.961e-210	673.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4DAUE@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_4156916_15	649831.L083_0063	9.747e-106	346.0	COG0512@1|root,COG0512@2|Bacteria,2GJUX@201174|Actinobacteria,4D99R@85008|Micromonosporales	201174|Actinobacteria	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS2_k127_4156916_29	369723.Strop_0050	2.477e-19	98.0	2EHSF@1|root,33BI6@2|Bacteria,2GRN8@201174|Actinobacteria,4DEW7@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4156916_16	369723.Strop_0051	2.709e-88	312.0	COG3764@1|root,COG3764@2|Bacteria,2GKT6@201174|Actinobacteria,4DBS8@85008|Micromonosporales	201174|Actinobacteria	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
TLS2_k127_4156916_19	644283.Micau_0105	2.213e-83	285.0	COG3879@1|root,COG3879@2|Bacteria,2GJ9Y@201174|Actinobacteria,4D90T@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF881)	-	-	-	-	-	-	-	-	-	-	-	-	DUF881
TLS2_k127_4156916_25	219305.MCAG_02939	6.655e-38	146.0	2E4NY@1|root,32ZHR@2|Bacteria,2HUF8@201174|Actinobacteria,4DESP@85008|Micromonosporales	201174|Actinobacteria	D	Involved in cell division	crgA	-	-	-	-	-	-	-	-	-	-	-	CrgA
TLS2_k127_4156916_0	391037.Sare_0059	0.0	1062.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria,4D9DT@85008|Micromonosporales	201174|Actinobacteria	C	4Fe-4S dicluster domain	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
TLS2_k127_4156916_17	1150864.MILUP08_40082	1.603e-87	301.0	COG0791@1|root,COG0791@2|Bacteria,2GIWB@201174|Actinobacteria,4DC0B@85008|Micromonosporales	201174|Actinobacteria	M	NlpC/P60 family	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
TLS2_k127_4162883_8	356851.JOAN01000027_gene1276	5.534e-20	96.0	COG1622@1|root,COG1622@2|Bacteria,2GS05@201174|Actinobacteria,4DJJI@85008|Micromonosporales	201174|Actinobacteria	C	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
TLS2_k127_4162883_2	1464048.JNZS01000018_gene2083	4.342e-133	438.0	arCOG02771@1|root,2Z93M@2|Bacteria,2I3TS@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4162883_6	1246995.AFR_06505	3.294e-58	216.0	COG3064@1|root,COG3064@2|Bacteria,2IPR2@201174|Actinobacteria,4DE8E@85008|Micromonosporales	201174|Actinobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4162883_3	219305.MCAG_04129	1.924e-101	332.0	COG1949@1|root,COG1949@2|Bacteria,2GJR7@201174|Actinobacteria,4D9G7@85008|Micromonosporales	201174|Actinobacteria	L	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
TLS2_k127_4162883_4	35754.JNYJ01000047_gene3492	1.042e-94	314.0	COG0500@1|root,COG2226@2|Bacteria,2IAGR@201174|Actinobacteria,4DIQB@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_4162883_1	471852.Tcur_0026	3.561e-172	550.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4EGT2@85012|Streptosporangiales	201174|Actinobacteria	S	SMART CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_4162883_9	543632.JOJL01000024_gene1977	5.117e-05	55.0	COG1595@1|root,COG3693@1|root,COG1595@2|Bacteria,COG3693@2|Bacteria,2GJSN@201174|Actinobacteria	201174|Actinobacteria	G	PFAM glycoside hydrolase, family 10	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,Glyco_hydro_10,Glyco_hydro_62,RicinB_lectin_2
TLS2_k127_4162883_10	1122622.ATWJ01000008_gene2864	5.664e-05	53.0	COG1595@1|root,COG1595@2|Bacteria,2GP2X@201174|Actinobacteria,4FJWA@85021|Intrasporangiaceae	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_4162883_5	1122182.KB903814_gene3367	3.773e-60	223.0	29YKI@1|root,30KFU@2|Bacteria,2HWZE@201174|Actinobacteria,4DKTN@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4162883_7	1122611.KB903959_gene4164	2.889e-46	176.0	COG3795@1|root,COG3795@2|Bacteria,2IK6B@201174|Actinobacteria,4EQWB@85012|Streptosporangiales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_4162883_0	298654.FraEuI1c_3485	9.312e-213	668.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4ERCP@85013|Frankiales	201174|Actinobacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4176876_12	391037.Sare_0695	4.881e-56	204.0	2FFRB@1|root,347NI@2|Bacteria,2ID0F@201174|Actinobacteria,4D8N3@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4176876_6	219305.MCAG_03506	2.8e-101	333.0	COG1670@1|root,COG1670@2|Bacteria,2HAFI@201174|Actinobacteria,4DAXY@85008|Micromonosporales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	rimJ	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS2_k127_4176876_0	644283.Micau_0711	4.171e-200	631.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4D9WA@85008|Micromonosporales	201174|Actinobacteria	H	Molybdenum cofactor synthesis	moeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1,2.7.7.9	ko:K00963,ko:K03750	ko00040,ko00052,ko00500,ko00520,ko00790,ko01100,ko01130,map00040,map00052,map00500,map00520,map00790,map01100,map01130	M00129,M00361,M00362,M00549	R00289,R09735	RC00002,RC03462	ko00000,ko00001,ko00002,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS2_k127_4176876_2	33876.JNXY01000026_gene3419	5.551e-125	407.0	COG1210@1|root,COG1210@2|Bacteria,2I2EW@201174|Actinobacteria,4D8F2@85008|Micromonosporales	201174|Actinobacteria	M	Nucleotidyl transferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_4176876_1	33876.JNXY01000026_gene3418	2.916e-195	635.0	COG2199@1|root,COG3850@1|root,COG3706@2|Bacteria,COG3850@2|Bacteria,2IA4H@201174|Actinobacteria,4D9U5@85008|Micromonosporales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF,HAMP
TLS2_k127_4176876_13	33876.JNXY01000026_gene3417	9.621e-54	196.0	COG0212@1|root,COG0212@2|Bacteria,2IKWR@201174|Actinobacteria,4DCPT@85008|Micromonosporales	201174|Actinobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	ygfA	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
TLS2_k127_4176876_14	263358.VAB18032_08260	3.04e-31	126.0	COG2331@1|root,COG2331@2|Bacteria,2IQHE@201174|Actinobacteria,4DF8Z@85008|Micromonosporales	201174|Actinobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TLS2_k127_4176876_18	219305.MCAG_03500	2.314e-12	77.0	2BCQK@1|root,326B0@2|Bacteria,2HBR5@201174|Actinobacteria,4DKVJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4176876_19	219305.MCAG_03499	6.488e-11	68.0	296CA@1|root,2ZTN3@2|Bacteria,2GS4E@201174|Actinobacteria,4DFS4@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4176876_16	1246995.AFR_39935	4.491e-19	96.0	2DBEB@1|root,32TXC@2|Bacteria,2GQG1@201174|Actinobacteria,4DF16@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4176876_4	1150864.MILUP08_40793	1.329e-108	361.0	COG3662@1|root,COG3662@2|Bacteria,2GJD2@201174|Actinobacteria,4DBP6@85008|Micromonosporales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
TLS2_k127_4176876_7	909613.UO65_5998	2.311e-90	305.0	COG3823@1|root,COG3823@2|Bacteria,2GMGV@201174|Actinobacteria,4DX41@85010|Pseudonocardiales	201174|Actinobacteria	M	Glutamine cyclotransferase	-	-	2.3.2.5	ko:K00683	-	-	-	-	ko00000,ko01000	-	-	-	Glu_cyclase_2
TLS2_k127_4176876_9	208439.AJAP_02200	1.283e-84	293.0	COG1226@1|root,2Z7ZD@2|Bacteria,2IC5E@201174|Actinobacteria,4E0SQ@85010|Pseudonocardiales	201174|Actinobacteria	P	Polycystin cation channel	-	-	-	ko:K08714	-	-	-	-	ko00000,ko02000	1.A.1.14	-	-	Ion_trans
TLS2_k127_4176876_3	391037.Sare_0683	1.283e-119	394.0	COG2887@1|root,COG2887@2|Bacteria,2I94N@201174|Actinobacteria,4D9UD@85008|Micromonosporales	201174|Actinobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
TLS2_k127_4176876_15	644283.Micau_0697	4.453e-27	126.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	SGL,WD40
TLS2_k127_4176876_10	1121946.AUAX01000005_gene5300	2.987e-80	274.0	COG1595@1|root,COG1595@2|Bacteria,2GP81@201174|Actinobacteria,4DD59@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigE	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4176876_8	33876.JNXY01000026_gene3405	1.292e-89	303.0	COG3428@1|root,COG3428@2|Bacteria,2IA1C@201174|Actinobacteria,4DAKZ@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
TLS2_k127_4176876_17	391037.Sare_0679	8.051e-15	76.0	2ETIN@1|root,33M2G@2|Bacteria,2GUAW@201174|Actinobacteria,4DFY5@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4176876_11	512565.AMIS_75450	6.961e-79	269.0	29V8K@1|root,30GNI@2|Bacteria,2GM77@201174|Actinobacteria,4DCX1@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4176876_5	644283.Micau_0692	9.048e-107	350.0	COG0566@1|root,COG0566@2|Bacteria,2GM1A@201174|Actinobacteria,4DB7B@85008|Micromonosporales	201174|Actinobacteria	J	tRNA rRNA methyltransferase	trmH	-	2.1.1.34	ko:K00556	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
TLS2_k127_4193900_3	644283.Micau_1327	4.38e-136	439.0	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria,4DAED@85008|Micromonosporales	201174|Actinobacteria	Q	Domain of unknown function (DUF2437)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
TLS2_k127_4193900_4	219305.MCAG_04218	1.256e-122	396.0	COG1414@1|root,COG1414@2|Bacteria,2GKB0@201174|Actinobacteria,4D8H2@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	ltbR	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS2_k127_4193900_1	219305.MCAG_04219	2.973e-250	781.0	COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria,4D8HH@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TLS2_k127_4193900_5	219305.MCAG_04220	1.954e-85	300.0	COG0066@1|root,COG0066@2|Bacteria,2GJ8Z@201174|Actinobacteria,4D98T@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2987c	Aconitase_C
TLS2_k127_4193900_8	369723.Strop_1260	1.741e-48	179.0	COG0776@1|root,COG0776@2|Bacteria,2GV0M@201174|Actinobacteria,4DDIV@85008|Micromonosporales	201174|Actinobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006355,GO:0006725,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010106,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019725,GO:0030003,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0040007,GO:0042262,GO:0042592,GO:0042594,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046916,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0060255,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090143,GO:0090304,GO:0097100,GO:0097159,GO:0098771,GO:0140110,GO:1901360,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_4193900_6	33876.JNXY01000027_gene3681	7.069e-67	243.0	COG0406@1|root,COG0494@1|root,COG0406@2|Bacteria,COG0494@2|Bacteria,2GNRV@201174|Actinobacteria,4DB83@85008|Micromonosporales	201174|Actinobacteria	GL	Nudix hydrolase	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
TLS2_k127_4193900_2	33876.JNXY01000027_gene3680	1.668e-152	497.0	COG5607@1|root,COG5607@2|Bacteria,2GJZH@201174|Actinobacteria,4D8I4@85008|Micromonosporales	201174|Actinobacteria	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
TLS2_k127_4193900_0	1150864.MILUP08_41417	0.0	1079.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria,4DAX1@85008|Micromonosporales	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
TLS2_k127_4193900_9	644283.Micau_1335	2.728e-22	98.0	COG1920@1|root,COG1920@2|Bacteria,2HJNU@201174|Actinobacteria,4DDTA@85008|Micromonosporales	201174|Actinobacteria	S	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC,NTP_transf_3
TLS2_k127_4193900_7	1150864.MILUP08_41419	1.273e-56	205.0	COG1920@1|root,COG1920@2|Bacteria,2HJNU@201174|Actinobacteria,4DDTA@85008|Micromonosporales	201174|Actinobacteria	S	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC,NTP_transf_3
TLS2_k127_4207504_10	1121946.AUAX01000005_gene5179	1.569e-97	329.0	2EG33@1|root,339V2@2|Bacteria,2IAA2@201174|Actinobacteria,4DA08@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4207504_15	356851.JOAN01000015_gene2666	1.771e-43	167.0	COG3335@1|root,COG3335@2|Bacteria,2I3UB@201174|Actinobacteria,4DMNW@85008|Micromonosporales	201174|Actinobacteria	L	Protein of unknown function (DUF2993)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2993
TLS2_k127_4207504_0	390989.JOEG01000027_gene2194	1.213e-160	510.0	COG2897@1|root,COG2897@2|Bacteria,2GIYU@201174|Actinobacteria,4DAIE@85008|Micromonosporales	201174|Actinobacteria	P	Sulfurtransferase	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS2_k127_4207504_16	649831.L083_7751	1.344e-35	141.0	2E36U@1|root,32Y6I@2|Bacteria,2IM2G@201174|Actinobacteria,4DE1X@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF1416)	sseC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF1416
TLS2_k127_4207504_17	35754.JNYJ01000038_gene4949	3.423e-20	99.0	291JI@1|root,2ZP5X@2|Bacteria,2IIDE@201174|Actinobacteria,4DDVT@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4207504_13	219305.MCAG_02275	7.645e-50	184.0	COG2044@1|root,COG2044@2|Bacteria,2IHT6@201174|Actinobacteria,4DDC3@85008|Micromonosporales	201174|Actinobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
TLS2_k127_4207504_21	263358.VAB18032_02085	2.6e-06	52.0	29W41@1|root,30HNV@2|Bacteria,2GYN0@201174|Actinobacteria,4DGG1@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4207504_8	644283.Micau_5709	6.278e-100	329.0	COG4044@1|root,COG4044@2|Bacteria,2GKGF@201174|Actinobacteria,4DBKD@85008|Micromonosporales	201174|Actinobacteria	S	May play a role in the intracellular transport of hydrophobic ligands	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF1794
TLS2_k127_4207504_22	1122182.KB903813_gene2114	7.398e-05	52.0	COG0515@1|root,COG0515@2|Bacteria	1122182.KB903813_gene2114|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4207504_9	1464048.JNZS01000002_gene359	1.294e-99	332.0	COG0115@1|root,COG0115@2|Bacteria,2GN5Z@201174|Actinobacteria,4DCEQ@85008|Micromonosporales	201174|Actinobacteria	EH	Aminotransferase class IV	pabC	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
TLS2_k127_4207504_14	1121272.KB903249_gene2365	8.03e-50	191.0	COG0739@1|root,COG0739@2|Bacteria,2IMHS@201174|Actinobacteria,4DM08@85008|Micromonosporales	201174|Actinobacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4207504_11	369723.Strop_0312	3.916e-56	203.0	COG0735@1|root,COG0735@2|Bacteria,2IFHB@201174|Actinobacteria,4DEKA@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_4207504_2	1150864.MILUP08_46528	1.197e-145	471.0	COG0354@1|root,COG0354@2|Bacteria,2GKP0@201174|Actinobacteria,4D8W2@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the GcvT family	ygfZ	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
TLS2_k127_4207504_3	1121946.AUAX01000005_gene5186	1.404e-134	433.0	COG3246@1|root,COG3246@2|Bacteria,2I9EQ@201174|Actinobacteria,4DA44@85008|Micromonosporales	201174|Actinobacteria	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
TLS2_k127_4207504_6	1464048.JNZS01000002_gene355	2.658e-122	402.0	COG4448@1|root,COG4448@2|Bacteria,2GJA7@201174|Actinobacteria,4D8HT@85008|Micromonosporales	201174|Actinobacteria	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
TLS2_k127_4207504_12	1120949.KB903306_gene7529	9.004e-51	183.0	COG1396@1|root,COG1396@2|Bacteria,2IKVI@201174|Actinobacteria,4DEB3@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix domain	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
TLS2_k127_4207504_20	369723.Strop_0317	7.04e-09	64.0	2C9DM@1|root,2ZE8V@2|Bacteria,2I2XK@201174|Actinobacteria,4DETA@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4207504_18	33876.JNXY01000019_gene7639	2.536e-19	98.0	2BNW2@1|root,32HJX@2|Bacteria,2GQ4M@201174|Actinobacteria,4DFE2@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF2516)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2516
TLS2_k127_4207504_4	644283.Micau_5698	3.349e-133	427.0	COG2872@1|root,COG2872@2|Bacteria,2I8P6@201174|Actinobacteria,4DAMA@85008|Micromonosporales	201174|Actinobacteria	S	Threonyl and Alanyl tRNA synthetase second additional domain	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
TLS2_k127_4207504_7	390989.JOEG01000027_gene2211	9.476e-107	371.0	COG3568@1|root,COG3568@2|Bacteria,2GP1E@201174|Actinobacteria,4D8H0@85008|Micromonosporales	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_4207504_1	644283.Micau_5689	2.057e-151	489.0	COG1609@1|root,COG1609@2|Bacteria,2GJV7@201174|Actinobacteria,4DASY@85008|Micromonosporales	201174|Actinobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
TLS2_k127_4207504_5	356851.JOAN01000015_gene2696	1.441e-128	419.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria,4DAN2@85008|Micromonosporales	201174|Actinobacteria	G	Beta-glucosidase	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
TLS2_k127_4260934_23	58123.JOFJ01000035_gene4645	5.588e-79	274.0	COG2866@1|root,COG3227@1|root,COG2866@2|Bacteria,COG3227@2|Bacteria,2I341@201174|Actinobacteria,4EQZU@85012|Streptosporangiales	201174|Actinobacteria	E	Fungalysin/Thermolysin Propeptide Motif	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
TLS2_k127_4260934_44	1157637.KB892090_gene6581	1.66e-05	49.0	COG0500@1|root,COG0500@2|Bacteria,2IGTT@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4260934_36	1206725.BAFU01000044_gene2056	4.504e-41	166.0	2B0XT@1|root,31TAQ@2|Bacteria,2GWC5@201174|Actinobacteria,4FVP3@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4260934_13	211114.JOEF01000004_gene6641	3.63e-125	409.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4E22U@85010|Pseudonocardiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_4260934_17	1068980.ARVW01000001_gene6159	3.135e-113	379.0	COG3173@1|root,COG3173@2|Bacteria,2I4D0@201174|Actinobacteria,4E544@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_4260934_21	251221.35210582	1.363e-86	293.0	COG0745@1|root,COG0745@2|Bacteria,1FZWD@1117|Cyanobacteria	1117|Cyanobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_4260934_14	211165.AJLN01000143_gene1404	3.044e-124	415.0	COG0642@1|root,COG2205@2|Bacteria,1G17B@1117|Cyanobacteria,1JJMS@1189|Stigonemataceae	1117|Cyanobacteria	T	HAMP domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_4260934_9	356851.JOAN01000036_gene477	2.534e-140	455.0	COG0642@1|root,COG2205@2|Bacteria,2GJMV@201174|Actinobacteria,4DB2W@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	cutS	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_4260934_16	263358.VAB18032_12675	3.055e-115	374.0	COG0745@1|root,COG0745@2|Bacteria,2GKYV@201174|Actinobacteria,4D9HR@85008|Micromonosporales	201174|Actinobacteria	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_4260934_20	1246995.AFR_27020	9.035e-97	329.0	COG0656@1|root,COG0656@2|Bacteria,2HGQC@201174|Actinobacteria,4DCC2@85008|Micromonosporales	201174|Actinobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_4260934_32	134676.ACPL_1841	1.155e-47	181.0	COG0740@1|root,COG0740@2|Bacteria,2GPTS@201174|Actinobacteria,4DF0Y@85008|Micromonosporales	201174|Actinobacteria	OU	Belongs to the peptidase S14 family	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TLS2_k127_4260934_19	570268.ANBB01000108_gene4492	1.363e-105	351.0	COG0730@1|root,COG0730@2|Bacteria,2GNPE@201174|Actinobacteria,4EI0K@85012|Streptosporangiales	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	cysZ	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_4260934_35	263358.VAB18032_28251	2.899e-41	160.0	2BIEE@1|root,32T9G@2|Bacteria,2I86Y@201174|Actinobacteria,4DD6X@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4260934_28	1120950.KB892708_gene4506	3.044e-61	218.0	29RUH@1|root,30CYE@2|Bacteria,2HHM4@201174|Actinobacteria,4DN62@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4260934_2	479432.Sros_3809	5.738e-283	889.0	COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria,4EMM0@85012|Streptosporangiales	201174|Actinobacteria	O	HypF finger	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
TLS2_k127_4260934_6	211114.JOEF01000008_gene1186	6.42e-154	496.0	COG0309@1|root,COG0309@2|Bacteria,2GJ7N@201174|Actinobacteria,4DXSM@85010|Pseudonocardiales	201174|Actinobacteria	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
TLS2_k127_4260934_3	479432.Sros_3823	2.813e-214	670.0	COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria,4EG4Q@85012|Streptosporangiales	201174|Actinobacteria	O	Hydrogenase formation hypA family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
TLS2_k127_4260934_37	1089545.KB913037_gene4809	9.234e-35	140.0	COG0298@1|root,COG0298@2|Bacteria,2IRJ9@201174|Actinobacteria,4E5W4@85010|Pseudonocardiales	201174|Actinobacteria	O	Hydrogenase assembly chaperone hypC hupF	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
TLS2_k127_4260934_39	479432.Sros_3821	3.797e-28	117.0	COG0375@1|root,COG0375@2|Bacteria,2I146@201174|Actinobacteria,4EKU8@85012|Streptosporangiales	201174|Actinobacteria	S	Hydrogenase/urease nickel incorporation, metallochaperone, hypA	-	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
TLS2_k127_4260934_34	208444.JNYY01000034_gene2602	5.576e-43	179.0	COG0680@1|root,COG0680@2|Bacteria,2GN48@201174|Actinobacteria,4E5CZ@85010|Pseudonocardiales	201174|Actinobacteria	C	TIGRFAM hydrogenase maturation protease	hupD1	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
TLS2_k127_4260934_12	211114.JOEF01000008_gene1182	1.002e-125	428.0	COG0680@1|root,COG0680@2|Bacteria,2GKMU@201174|Actinobacteria,4E14D@85010|Pseudonocardiales	201174|Actinobacteria	C	Initiates the rapid degradation of small, acid-soluble proteins during spore germination	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4260934_22	479432.Sros_3817	4.249e-79	274.0	29Z4R@1|root,30M2D@2|Bacteria,2GNPH@201174|Actinobacteria,4EPH3@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4260934_29	1089545.KB913037_gene4814	7.387e-58	214.0	2ADVU@1|root,313MT@2|Bacteria,2H7PH@201174|Actinobacteria,4E59S@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4260934_38	749927.AMED_3794	5.866e-32	135.0	COG0694@1|root,COG0694@2|Bacteria,2GKHD@201174|Actinobacteria,4E7UH@85010|Pseudonocardiales	201174|Actinobacteria	O	NifU-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NifU,Rieske
TLS2_k127_4260934_0	479432.Sros_3814	0.0	1080.0	COG0374@1|root,COG0374@2|Bacteria,2GKQY@201174|Actinobacteria,4EGJR@85012|Streptosporangiales	201174|Actinobacteria	C	Nickel-dependent hydrogenase	hydB	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
TLS2_k127_4260934_4	208444.JNYY01000034_gene2608	5.363e-203	640.0	COG1740@1|root,COG1740@2|Bacteria,2GKF2@201174|Actinobacteria,4DY4Z@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
TLS2_k127_4260934_26	1089545.KB913037_gene4818	4.743e-71	250.0	COG0279@1|root,COG0279@2|Bacteria,2GM2Q@201174|Actinobacteria,4DYUA@85010|Pseudonocardiales	201174|Actinobacteria	G	phosphoheptose isomerase	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
TLS2_k127_4260934_41	405948.SACE_3070	5.728e-17	85.0	COG0298@1|root,COG0298@2|Bacteria,2GXP3@201174|Actinobacteria,4E7HH@85010|Pseudonocardiales	201174|Actinobacteria	O	PFAM HupF HypC family	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
TLS2_k127_4260934_27	414996.IL38_15095	5.26e-71	246.0	COG0279@1|root,COG0279@2|Bacteria,2IG0T@201174|Actinobacteria	201174|Actinobacteria	G	SIS domain	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
TLS2_k127_4260934_31	649831.L083_4482	1.339e-48	178.0	2CDI4@1|root,32YR4@2|Bacteria,2IINI@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4260934_40	326427.Cagg_1115	6.995e-28	124.0	2EU2Z@1|root,33MJU@2|Bacteria,2G8PR@200795|Chloroflexi,3778I@32061|Chloroflexia	32061|Chloroflexia	H	PFAM ribosomal RNA methyltransferase	-	-	2.1.1.179	ko:K18845	-	-	-	-	br01600,ko00000,ko01000,ko01504,ko03009	-	-	-	FmrO
TLS2_k127_4260934_1	369723.Strop_4404	0.0	1054.0	COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4DBHN@85008|Micromonosporales	201174|Actinobacteria	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS2_k127_4260934_42	1121272.KB903289_gene4301	7.115e-15	82.0	COG1366@1|root,COG1366@2|Bacteria,2GQBG@201174|Actinobacteria,4DFF7@85008|Micromonosporales	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
TLS2_k127_4260934_25	675635.Psed_3623	2.842e-73	273.0	COG2208@1|root,COG2208@2|Bacteria,2GK8P@201174|Actinobacteria,4DZ97@85010|Pseudonocardiales	201174|Actinobacteria	T	Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,PAS,PAS_3,PAS_4,SpoIIE
TLS2_k127_4260934_33	118163.Ple7327_2124	3.703e-47	180.0	COG3551@1|root,COG3551@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_transf_4,Glyco_transf_41,Glycos_transf_1,Glycos_transf_2,Sulfotransfer_3
TLS2_k127_4260934_18	1449347.JQLN01000004_gene6310	4.913e-108	357.0	COG0657@1|root,COG0657@2|Bacteria,2GKX2@201174|Actinobacteria,2M17J@2063|Kitasatospora	201174|Actinobacteria	I	Carboxylesterase family	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
TLS2_k127_4260934_5	1463900.JOIX01000035_gene3755	7.087e-164	527.0	COG1167@1|root,COG1167@2|Bacteria,2I310@201174|Actinobacteria	201174|Actinobacteria	EK	Pfam Aminotransferase class I and II	-	-	2.6.1.103	ko:K16423	ko00261,ko01055,ko01130,map00261,map01055,map01130	-	R06626,R06634	RC00006,RC01104	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
TLS2_k127_4260934_10	1123319.AUBE01000014_gene5540	2.749e-131	433.0	COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase	-	-	1.1.3.46	ko:K16422	ko00261,ko01055,ko01130,map00261,map01055,map01130	-	R06633	RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
TLS2_k127_4260934_30	1380346.JNIH01000010_gene3038	2.585e-49	189.0	COG2091@1|root,COG2091@2|Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	2.7.8.7	ko:K00997,ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_4260934_8	1464048.JNZS01000004_gene1308	2.104e-140	455.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,4D8H1@85008|Micromonosporales	201174|Actinobacteria	V	Daunorubicin resistance abc transporter atpase subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_4260934_43	1157640.AQWO01000004_gene4806	8.116e-12	70.0	COG0236@1|root,COG0236@2|Bacteria,2GS1P@201174|Actinobacteria	201174|Actinobacteria	IQ	Acyl carrier protein	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS2_k127_4260934_15	1463856.JOHY01000001_gene393	5.854e-119	397.0	COG1819@1|root,COG1819@2|Bacteria,2GJN7@201174|Actinobacteria	201174|Actinobacteria	CG	Glycosyltransferase, MGT family	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
TLS2_k127_4260934_7	1120934.KB894407_gene5057	5.595e-149	477.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4E1T8@85010|Pseudonocardiales	201174|Actinobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_4260934_11	1120934.KB894407_gene5056	6.181e-130	426.0	COG1071@1|root,COG1071@2|Bacteria,2I3T8@201174|Actinobacteria,4E079@85010|Pseudonocardiales	201174|Actinobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS2_k127_4260934_24	1121272.KB903249_gene2305	3.728e-76	258.0	28HKZ@1|root,2Z7VP@2|Bacteria,2IANB@201174|Actinobacteria,4DB6K@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3050)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3050
TLS2_k127_4280290_7	1121946.AUAX01000009_gene4347	9.207e-46	171.0	COG2267@1|root,COG2267@2|Bacteria,2HUEM@201174|Actinobacteria,4DEP2@85008|Micromonosporales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_4280290_5	35754.JNYJ01000029_gene9473	4.013e-59	214.0	COG1028@1|root,COG1028@2|Bacteria,2IP6B@201174|Actinobacteria,4DMJG@85008|Micromonosporales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_4280290_0	644283.Micau_5112	7.668e-214	673.0	COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria,4D94A@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
TLS2_k127_4280290_3	644283.Micau_5113	1.699e-118	385.0	COG1637@1|root,COG1637@2|Bacteria,2GIYB@201174|Actinobacteria,4DAMI@85008|Micromonosporales	201174|Actinobacteria	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
TLS2_k127_4280290_8	1449069.JMLO01000019_gene2791	1.14e-43	164.0	COG3467@1|root,COG3467@2|Bacteria,2IQIK@201174|Actinobacteria,4G30K@85025|Nocardiaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_4280290_10	649831.L083_1053	1.242e-13	78.0	2DQ7G@1|root,3353J@2|Bacteria,2ISPG@201174|Actinobacteria,4DF4K@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
TLS2_k127_4280290_2	1150864.MILUP08_45903	4.111e-139	446.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4DAH9@85008|Micromonosporales	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	hbd	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_4280290_1	33876.JNXY01000008_gene8409	9.231e-211	664.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4DAAS@85008|Micromonosporales	201174|Actinobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	GO:0008150,GO:0040007	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TLS2_k127_4280290_4	543632.JOJL01000007_gene5468	3.206e-87	291.0	COG2096@1|root,COG2096@2|Bacteria,2GMHN@201174|Actinobacteria,4DAC2@85008|Micromonosporales	201174|Actinobacteria	S	adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
TLS2_k127_4280290_6	644283.Micau_5128	1.55e-52	190.0	2E6YX@1|root,331I5@2|Bacteria,2IFIG@201174|Actinobacteria,4DD17@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF2550)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2550
TLS2_k127_4280290_9	1464048.JNZS01000011_gene4840	2.587e-36	140.0	COG0355@1|root,COG0355@2|Bacteria,2IHNZ@201174|Actinobacteria,4DEUZ@85008|Micromonosporales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
TLS2_k127_4305286_4	512565.AMIS_17010	4.675e-79	273.0	COG1988@1|root,COG1988@2|Bacteria,2GMNG@201174|Actinobacteria,4DA7E@85008|Micromonosporales	201174|Actinobacteria	S	membrane-bound metal-dependent	-	-	-	-	-	-	-	-	-	-	-	-	YdjM
TLS2_k127_4305286_11	1463900.JOIX01000048_gene7848	3.563e-33	144.0	COG1787@1|root,COG2310@1|root,COG1787@2|Bacteria,COG2310@2|Bacteria,2I2Y8@201174|Actinobacteria	201174|Actinobacteria	TV	Restriction endonuclease	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_cat,TerD
TLS2_k127_4305286_0	1463917.JODC01000017_gene2493	8.592e-180	574.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria	201174|Actinobacteria	M	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_4305286_6	471852.Tcur_2788	6.645e-65	233.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
TLS2_k127_4305286_8	1463887.KL589967_gene6638	3.766e-57	205.0	COG5587@1|root,COG5587@2|Bacteria,2IJG5@201174|Actinobacteria	201174|Actinobacteria	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
TLS2_k127_4305286_1	512565.AMIS_72580	1.061e-127	413.0	COG0266@1|root,COG0266@2|Bacteria,2GKUI@201174|Actinobacteria,4D97D@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the FPG family	nei1	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0003906,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034599,GO:0034641,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0090304,GO:0097159,GO:0097506,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K05522,ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_4305286_3	543632.JOJL01000017_gene9894	1.45e-81	282.0	COG0530@1|root,COG0530@2|Bacteria,2GJR3@201174|Actinobacteria,4DA14@85008|Micromonosporales	201174|Actinobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
TLS2_k127_4305286_5	134676.ACPL_4620	1.785e-73	250.0	COG0789@1|root,COG0789@2|Bacteria,2IC98@201174|Actinobacteria,4DGJB@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_4305286_7	710696.Intca_0160	2.217e-64	230.0	COG0863@1|root,COG0863@2|Bacteria,2I9A6@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
TLS2_k127_4305286_9	356851.JOAN01000015_gene2694	4.94e-45	166.0	COG0251@1|root,COG0251@2|Bacteria,2IHP3@201174|Actinobacteria,4DE1Q@85008|Micromonosporales	201174|Actinobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS2_k127_4305286_12	656024.FsymDg_1251	4.672e-19	91.0	COG0864@1|root,COG0864@2|Bacteria,2GZCR@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
TLS2_k127_4305286_10	419947.MRA_2006	1.01e-41	156.0	COG2337@1|root,COG2337@2|Bacteria,2IQQ9@201174|Actinobacteria	201174|Actinobacteria	L	Toxic component of a toxin-antitoxin (TA) module	-	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005576,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045926,GO:0045927,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
TLS2_k127_4305286_14	378806.STAUR_1993	8.166e-14	80.0	COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,42NX3@68525|delta/epsilon subdivisions,2WME4@28221|Deltaproteobacteria,2YX9W@29|Myxococcales	28221|Deltaproteobacteria	L	IS66 C-terminal element	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
TLS2_k127_4305286_2	246197.MXAN_6138	6.422e-115	370.0	COG0262@1|root,COG0262@2|Bacteria,1QH1Q@1224|Proteobacteria,4341U@68525|delta/epsilon subdivisions,2X4QE@28221|Deltaproteobacteria,2YZE6@29|Myxococcales	28221|Deltaproteobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_4319753_5	1150864.MILUP08_42515	1.974e-68	235.0	COG0781@1|root,COG0781@2|Bacteria,2IM3D@201174|Actinobacteria,4DDV6@85008|Micromonosporales	201174|Actinobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	GO:0008150,GO:0040007	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
TLS2_k127_4319753_3	1136417.AZWE01000003_gene3355	1.462e-104	341.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4D9B4@85008|Micromonosporales	201174|Actinobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TLS2_k127_4319753_0	471852.Tcur_2454	1e-196	621.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4EGKI@85012|Streptosporangiales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	adhC	-	1.1.1.306	ko:K00153	-	-	R09129,R10301	RC00069,RC01715	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_4319753_6	1313172.YM304_34870	1.412e-57	208.0	COG5663@1|root,COG5663@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K05967	-	-	-	-	ko00000	-	-	-	NT5C
TLS2_k127_4319753_1	1116232.AHBF01000015_gene3634	1.173e-193	617.0	COG1672@1|root,COG1672@2|Bacteria,2IBJ4@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Archaeal ATPase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4319753_4	1136417.AZWE01000003_gene3356	2.491e-69	237.0	COG0757@1|root,COG0757@2|Bacteria,2IMBY@201174|Actinobacteria,4DCSF@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	GO:0003674,GO:0003824,GO:0003855,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
TLS2_k127_4319753_2	644283.Micau_2326	5.972e-135	434.0	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria,4D9CC@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829,ko:K16020	ko00400,ko01051,ko01100,ko01110,ko01130,ko01230,map00400,map01051,map01100,map01110,map01130,map01230	M00022	R02412,R03083,R06592	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
TLS2_k127_4397445_6	369723.Strop_3023	1.616e-53	190.0	COG0276@1|root,COG0276@2|Bacteria,2GJTQ@201174|Actinobacteria,4D92F@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
TLS2_k127_4397445_2	219305.MCAG_01026	8.666e-142	455.0	COG0647@1|root,COG0647@2|Bacteria,2GJG6@201174|Actinobacteria,4D9V7@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the HAD-like hydrolase superfamily	nagD	-	-	ko:K02566	-	-	-	-	ko00000	-	-	-	Hydrolase_6,Hydrolase_like
TLS2_k127_4397445_4	1150864.MILUP08_44870	5.266e-101	341.0	2BK9Y@1|root,32EQ4@2|Bacteria,2GMZH@201174|Actinobacteria,4DAA7@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4397445_7	134676.ACPL_1930	1.848e-36	153.0	COG1585@1|root,COG1585@2|Bacteria,2IHZU@201174|Actinobacteria,4DDJ4@85008|Micromonosporales	201174|Actinobacteria	OU	Membrane protein implicated in regulation of membrane protease activity	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
TLS2_k127_4397445_1	391037.Sare_3244	8.648e-148	476.0	COG0330@1|root,COG0330@2|Bacteria,2GJ1U@201174|Actinobacteria,4D9NJ@85008|Micromonosporales	201174|Actinobacteria	O	prohibitin homologues	hflK	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_4397445_3	1121946.AUAX01000012_gene6562	1.684e-114	381.0	COG0566@1|root,COG0566@2|Bacteria,2GJ12@201174|Actinobacteria,4DAKP@85008|Micromonosporales	201174|Actinobacteria	J	tRNA rRNA methyltransferase	spoU2	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
TLS2_k127_4397445_0	219305.MCAG_00995	7.001e-223	703.0	COG0749@1|root,COG0749@2|Bacteria,2GM8R@201174|Actinobacteria,4D8YV@85008|Micromonosporales	201174|Actinobacteria	L	DNA polymerase	polA2	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_pol_A
TLS2_k127_4397445_5	1464048.JNZS01000035_gene2423	5.853e-60	217.0	COG2068@1|root,COG2068@2|Bacteria,2GK5R@201174|Actinobacteria,4DEMP@85008|Micromonosporales	201174|Actinobacteria	S	MobA-like NTP transferase domain	-	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TLS2_k127_443415_8	512565.AMIS_69120	1.563e-14	77.0	COG1573@1|root,COG1573@2|Bacteria,2GMPT@201174|Actinobacteria,4DA7F@85008|Micromonosporales	201174|Actinobacteria	L	Uracil-DNA glycosylase	dpo	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_443415_6	35754.JNYJ01000012_gene962	9.853e-62	227.0	COG1357@1|root,COG1357@2|Bacteria,2GK0E@201174|Actinobacteria,4DDVI@85008|Micromonosporales	201174|Actinobacteria	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
TLS2_k127_443415_5	644283.Micau_2572	1.946e-74	252.0	COG3945@1|root,COG3945@2|Bacteria,2IISC@201174|Actinobacteria,4DDVU@85008|Micromonosporales	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS2_k127_443415_4	68170.KL590540_gene9835	1.121e-98	329.0	COG0421@1|root,COG0421@2|Bacteria,2I2TN@201174|Actinobacteria,4E028@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_443415_10	1463879.JOHP01000030_gene5370	2.074e-05	47.0	COG1573@1|root,COG1573@2|Bacteria,2GMPT@201174|Actinobacteria	201174|Actinobacteria	L	Uracil-DNA glycosylase	dpo	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_443415_7	356851.JOAN01000012_gene5127	1.718e-19	97.0	COG1573@1|root,COG1573@2|Bacteria,2GMPT@201174|Actinobacteria,4DA7F@85008|Micromonosporales	201174|Actinobacteria	L	Uracil-DNA glycosylase	dpo	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_443415_3	1150864.MILUP08_42534	4.844e-206	669.0	COG3903@1|root,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4DAE4@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31,NB-ARC,TPR_12,TPR_7
TLS2_k127_443415_0	1463895.JODA01000010_gene7088	0.0	1345.0	COG0515@1|root,COG0515@2|Bacteria,2GMRN@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	LANC_like
TLS2_k127_443415_1	1463856.JOHY01000027_gene3700	1.78e-241	756.0	COG1132@1|root,COG1132@2|Bacteria,2IBC1@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
TLS2_k127_443415_2	644283.Micau_1530	1.562e-219	685.0	COG1960@1|root,COG1960@2|Bacteria,2GM3V@201174|Actinobacteria,4D8PA@85008|Micromonosporales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_4465921_28	33876.JNXY01000001_gene5620	6.951e-73	247.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4DC6X@85008|Micromonosporales	201174|Actinobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	garA	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
TLS2_k127_4465921_38	263358.VAB18032_20815	8.338e-54	193.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4DE4E@85008|Micromonosporales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iNJ661.Rv1826	GCV_H
TLS2_k127_4465921_34	219305.MCAG_00150	2.583e-63	230.0	COG3879@1|root,COG3879@2|Bacteria,2GJ3C@201174|Actinobacteria,4DD3G@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF881)	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF881
TLS2_k127_4465921_40	134676.ACPL_5076	4.812e-47	171.0	COG3856@1|root,COG3856@2|Bacteria,2IKJW@201174|Actinobacteria,4DE03@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF1290)	sbp	-	-	-	-	-	-	-	-	-	-	-	DUF1290
TLS2_k127_4465921_29	356851.JOAN01000035_gene1933	1.955e-72	260.0	COG3879@1|root,COG3879@2|Bacteria,2GMS5@201174|Actinobacteria,4D8IR@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF881)	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF881
TLS2_k127_4465921_30	644283.Micau_3223	8.13e-71	244.0	COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4DAQQ@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA2	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_4465921_31	1385518.N798_16685	1.106e-69	251.0	COG0577@1|root,COG0577@2|Bacteria,2IG8W@201174|Actinobacteria,4FHRC@85021|Intrasporangiaceae	201174|Actinobacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_4465921_32	1385518.N798_16680	1.367e-65	234.0	COG1136@1|root,COG1136@2|Bacteria,2IGYA@201174|Actinobacteria,4FGZ0@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_4465921_36	1385519.N801_14410	6.771e-59	221.0	COG3409@1|root,COG3409@2|Bacteria,2IIDJ@201174|Actinobacteria,4FHXW@85021|Intrasporangiaceae	201174|Actinobacteria	M	PFAM Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
TLS2_k127_4465921_48	446468.Ndas_0032	1.118e-07	63.0	COG1595@1|root,COG1595@2|Bacteria,2IRNG@201174|Actinobacteria,4EJ1H@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4465921_37	390989.JOEG01000005_gene1869	2.905e-56	206.0	COG3427@1|root,COG3427@2|Bacteria,2GKTQ@201174|Actinobacteria,4DECT@85008|Micromonosporales	201174|Actinobacteria	S	Carbon monoxide dehydrogenase subunit	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
TLS2_k127_4465921_8	1380393.JHVP01000015_gene4235	1.393e-162	521.0	COG1975@1|root,COG1975@2|Bacteria,2GIZS@201174|Actinobacteria,4ERTW@85013|Frankiales	201174|Actinobacteria	O	XdhC Rossmann domain	xdhC	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS2_k127_4465921_18	35754.JNYJ01000054_gene9716	4.843e-112	378.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4DGQN@85008|Micromonosporales	201174|Actinobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS2_k127_4465921_14	1068978.AMETH_1904	5.515e-130	422.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4E87H@85010|Pseudonocardiales	201174|Actinobacteria	O	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
TLS2_k127_4465921_24	675635.Psed_2659	3.893e-83	288.0	COG1975@1|root,COG3350@1|root,COG1975@2|Bacteria,COG3350@2|Bacteria,2IA9U@201174|Actinobacteria,4DXW1@85010|Pseudonocardiales	201174|Actinobacteria	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
TLS2_k127_4465921_0	1122611.KB903944_gene1178	0.0	1340.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4EFKM@85012|Streptosporangiales	201174|Actinobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_4465921_25	1122611.KB903944_gene1179	2.373e-81	272.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria,4EITW@85012|Streptosporangiales	201174|Actinobacteria	C	[2Fe-2S] binding domain	coxS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0374c	Fer2,Fer2_2
TLS2_k127_4465921_17	2074.JNYD01000012_gene204	4.191e-122	398.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4DXFH@85010|Pseudonocardiales	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0375c	CO_deh_flav_C,FAD_binding_5
TLS2_k127_4465921_35	1869.MB27_05565	1.04e-60	217.0	COG2068@1|root,COG2068@2|Bacteria,2GK5R@201174|Actinobacteria,4DEMP@85008|Micromonosporales	201174|Actinobacteria	S	MobA-like NTP transferase domain	-	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TLS2_k127_4465921_13	369723.Strop_2475	5.462e-130	426.0	COG1686@1|root,COG1686@2|Bacteria,2GK3M@201174|Actinobacteria,4D9FE@85008|Micromonosporales	201174|Actinobacteria	M	Belongs to the peptidase S11 family	dac	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
TLS2_k127_4465921_47	1122138.AQUZ01000001_gene1616	2.64e-16	85.0	2F90D@1|root,341C4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4465921_45	1122138.AQUZ01000001_gene1616	1.722e-30	123.0	2F90D@1|root,341C4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4465921_3	219305.MCAG_04968	8.125e-214	672.0	COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria,4D99U@85008|Micromonosporales	201174|Actinobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	Cytidylate_kin,KH_dom-like,MMR_HSR1
TLS2_k127_4465921_22	1136417.AZWE01000047_gene2725	2.286e-85	288.0	COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,4D918@85008|Micromonosporales	201174|Actinobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0040007,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
TLS2_k127_4465921_9	1120950.KB892763_gene5543	3.875e-146	479.0	COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria,4DR6Y@85009|Propionibacteriales	201174|Actinobacteria	C	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_4465921_21	1246995.AFR_29630	6.999e-98	325.0	COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,4DBFH@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_4465921_27	369723.Strop_1927	2.064e-76	266.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,4DA0T@85008|Micromonosporales	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
TLS2_k127_4465921_16	644283.Micau_2422	9.566e-128	415.0	COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria,4D8W9@85008|Micromonosporales	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
TLS2_k127_4465921_7	1246995.AFR_29870	2.547e-168	535.0	COG1192@1|root,COG1192@2|Bacteria,2GJX3@201174|Actinobacteria,4DAR4@85008|Micromonosporales	201174|Actinobacteria	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS2_k127_4465921_15	644283.Micau_2420	6.54e-129	419.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4DCDR@85008|Micromonosporales	201174|Actinobacteria	L	recombinase XerD	xerD	GO:0008150,GO:0040007	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_4465921_5	219305.MCAG_04961	3.192e-198	623.0	COG0686@1|root,COG0686@2|Bacteria,2GJ6G@201174|Actinobacteria,4DA3S@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TLS2_k127_4465921_41	479435.Kfla_2841	1.088e-43	166.0	COG1595@1|root,COG1595@2|Bacteria,2IMYU@201174|Actinobacteria	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4465921_33	219305.MCAG_04959	1.335e-63	228.0	COG0494@1|root,COG0494@2|Bacteria,2GNW6@201174|Actinobacteria,4D9G2@85008|Micromonosporales	201174|Actinobacteria	L	Nudix hydrolase	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TLS2_k127_4465921_1	369723.Strop_1920	1.425e-312	962.0	COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria,4DAJJ@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1699	CTP_synth_N,GATase
TLS2_k127_4465921_6	369723.Strop_1919	5.021e-191	619.0	COG4223@1|root,COG4223@2|Bacteria,2I2W3@201174|Actinobacteria,4DBAE@85008|Micromonosporales	201174|Actinobacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4465921_10	1464048.JNZS01000015_gene3815	1.108e-145	473.0	COG0438@1|root,COG0438@2|Bacteria,2GN28@201174|Actinobacteria,4D9E0@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_4465921_11	1136417.AZWE01000047_gene2713	2.642e-137	475.0	COG0728@1|root,COG0728@2|Bacteria,2GKWW@201174|Actinobacteria,4D9B9@85008|Micromonosporales	201174|Actinobacteria	S	Virulence factor mviN	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TLS2_k127_4465921_23	1121946.AUAX01000027_gene8007	1.359e-84	292.0	COG0472@1|root,COG0472@2|Bacteria,2HS8K@201174|Actinobacteria,4D8WC@85008|Micromonosporales	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4465921_26	33876.JNXY01000036_gene626	2.127e-77	270.0	2D1T0@1|root,32TBA@2|Bacteria,2I8E5@201174|Actinobacteria,4DBNF@85008|Micromonosporales	201174|Actinobacteria	S	Copper transport outer membrane protein, MctB	mctB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0008150,GO:0009279,GO:0015267,GO:0015288,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0044425,GO:0044462,GO:0044464,GO:0046930,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796	-	-	-	-	-	-	-	-	-	-	MctB
TLS2_k127_4465921_4	1464048.JNZS01000015_gene3819	2.31e-212	666.0	COG4825@1|root,COG4825@2|Bacteria,2GPAA@201174|Actinobacteria,4D96S@85008|Micromonosporales	201174|Actinobacteria	S	Thiamine pyrophosphokinase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TPPK_C
TLS2_k127_4465921_2	263358.VAB18032_15380	8.752e-267	834.0	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4DAX3@85008|Micromonosporales	201174|Actinobacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
TLS2_k127_4465921_12	356851.JOAN01000005_gene185	9.524e-137	440.0	COG0061@1|root,COG0061@2|Bacteria,2GKM2@201174|Actinobacteria,4DA20@85008|Micromonosporales	201174|Actinobacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006797,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
TLS2_k127_4465921_19	1150864.MILUP08_42601	1.598e-101	337.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,4DAFA@85008|Micromonosporales	201174|Actinobacteria	J	FtsJ-like methyltransferase	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
TLS2_k127_4465921_42	1122182.KB903838_gene3977	3.455e-37	148.0	COG3937@1|root,COG3937@2|Bacteria,2ISFA@201174|Actinobacteria,4DEZR@85008|Micromonosporales	201174|Actinobacteria	S	granule-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
TLS2_k127_4465921_44	219305.MCAG_04949	2.568e-36	146.0	COG3255@1|root,COG3255@2|Bacteria,2IM6I@201174|Actinobacteria,4DE6D@85008|Micromonosporales	201174|Actinobacteria	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
TLS2_k127_4465921_20	1370120.AUWR01000029_gene1604	1.242e-100	359.0	COG0457@1|root,COG0647@1|root,COG0457@2|Bacteria,COG0647@2|Bacteria,2GK7V@201174|Actinobacteria,233P0@1762|Mycobacteriaceae	201174|Actinobacteria	G	hydrolase	yutF	GO:0000121,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009987,GO:0016042,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030145,GO:0042578,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0046434,GO:0046475,GO:0046486,GO:0046503,GO:0046872,GO:0046914,GO:0046983,GO:0050897,GO:0071704,GO:1901575	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
TLS2_k127_4483332_40	1206101.AZXC01000056_gene5541	5.765e-09	64.0	COG1020@1|root,COG1020@2|Bacteria,2GRRE@201174|Actinobacteria	201174|Actinobacteria	Q	Condensation domain	-	-	-	ko:K21186	ko01059,map01059	-	-	-	ko00000,ko00001	-	-	-	AMP-binding,Condensation
TLS2_k127_4483332_4	479432.Sros_6948	5.526e-211	667.0	COG0365@1|root,COG0365@2|Bacteria,2GJVK@201174|Actinobacteria,4EMVZ@85012|Streptosporangiales	201174|Actinobacteria	I	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_4483332_25	1120934.KB894435_gene4456	6.981e-81	278.0	COG3483@1|root,COG3483@2|Bacteria,2GNB1@201174|Actinobacteria,4DYC6@85010|Pseudonocardiales	201174|Actinobacteria	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	-	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
TLS2_k127_4483332_10	479432.Sros_6950	6.075e-174	557.0	COG0520@1|root,COG0520@2|Bacteria,2GN15@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_4483332_36	345341.KUTG_02642	8.477e-48	180.0	COG4430@1|root,COG4430@2|Bacteria,2IN25@201174|Actinobacteria,4E5HN@85010|Pseudonocardiales	201174|Actinobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,OmdA
TLS2_k127_4483332_23	1463885.KL578380_gene9655	6.993e-93	313.0	COG2162@1|root,COG2162@2|Bacteria,2GP1R@201174|Actinobacteria	201174|Actinobacteria	Q	Belongs to the arylamine N-acetyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_2
TLS2_k127_4483332_43	391589.RGAI101_2476	1.554e-05	55.0	COG0438@1|root,COG0438@2|Bacteria,1R9FR@1224|Proteobacteria,2U3H6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
TLS2_k127_4483332_11	479432.Sros_6951	4.5e-173	554.0	COG1835@1|root,COG1835@2|Bacteria,2GP6W@201174|Actinobacteria,4EGES@85012|Streptosporangiales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS2_k127_4483332_12	479432.Sros_6987	4.186e-152	494.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4EMGP@85012|Streptosporangiales	201174|Actinobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_4483332_20	566461.SSFG_07654	1.528e-104	350.0	COG2890@1|root,COG2890@2|Bacteria,2I3DU@201174|Actinobacteria	201174|Actinobacteria	J	O-methyltransferase	-	-	2.1.1.303	ko:K20421,ko:K21178	ko01059,ko01130,map01059,map01130	M00826,M00830	R10963,R11364	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_2
TLS2_k127_4483332_9	287986.DV20_06900	1.204e-177	567.0	COG0644@1|root,COG0644@2|Bacteria,2GJDF@201174|Actinobacteria,4E4EN@85010|Pseudonocardiales	201174|Actinobacteria	C	Tryptophan halogenase	-	-	-	ko:K16033,ko:K21256	ko01051,ko01052,ko01059,ko01130,map01051,map01052,map01059,map01130	M00833,M00834	R09851,R11414	RC01363	ko00000,ko00001,ko00002	-	-	-	Trp_halogenase
TLS2_k127_4483332_21	479432.Sros_4134	1.031e-97	348.0	COG2267@1|root,COG2267@2|Bacteria,2GJUE@201174|Actinobacteria,4EJ5F@85012|Streptosporangiales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_4483332_5	479432.Sros_6964	4.476e-191	611.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4EH9X@85012|Streptosporangiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K08167	-	M00713,M00714	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.3	-	-	MFS_1
TLS2_k127_4483332_29	479432.Sros_6982	5.351e-67	233.0	COG0262@1|root,COG0262@2|Bacteria,2GYU7@201174|Actinobacteria,4EJS4@85012|Streptosporangiales	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_4483332_15	479432.Sros_6970	8.79e-135	442.0	COG3185@1|root,COG3185@2|Bacteria,2GKG8@201174|Actinobacteria,4EG6F@85012|Streptosporangiales	201174|Actinobacteria	E	Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal	-	-	1.13.11.46	ko:K16421	ko00261,ko01055,ko01130,map00261,map01055,map01130	-	R06632	RC01471	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4,Glyoxalase_5
TLS2_k127_4483332_8	1134445.AJJM01000004_gene3472	1.217e-181	574.0	COG3211@1|root,COG3211@2|Bacteria,2GJKE@201174|Actinobacteria	201174|Actinobacteria	G	Bacterial protein of unknown function (DUF839)	-	-	-	-	-	-	-	-	-	-	-	-	DUF839,PD40
TLS2_k127_4483332_39	1121946.AUAX01000004_gene895	2.505e-16	89.0	2B2WU@1|root,31VHF@2|Bacteria,2HWVE@201174|Actinobacteria,4DKGK@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4483332_2	1121946.AUAX01000004_gene896	6.47e-238	771.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2IAS1@201174|Actinobacteria,4D9ME@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_12,Trans_reg_C
TLS2_k127_4483332_14	134676.ACPL_6775	1.8e-139	475.0	COG5651@1|root,COG5651@2|Bacteria,2I57Z@201174|Actinobacteria,4DMKV@85008|Micromonosporales	2|Bacteria	N	PPE family	-	-	-	-	-	-	-	-	-	-	-	-	PPE
TLS2_k127_4483332_27	1122182.KB903835_gene4651	3.726e-78	270.0	COG0500@1|root,COG2226@2|Bacteria,2HWAV@201174|Actinobacteria,4DDUA@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_4483332_22	263358.VAB18032_13800	1.552e-96	329.0	COG1216@1|root,COG1216@2|Bacteria,2I2EQ@201174|Actinobacteria,4DBIC@85008|Micromonosporales	201174|Actinobacteria	S	Glycosyl transferase family 2	-	-	2.7.8.12	ko:K09809,ko:K19427	-	-	-	-	ko00000,ko01000	-	GT2	-	Glycos_transf_2
TLS2_k127_4483332_31	1121926.AXWO01000007_gene26	1.427e-59	218.0	COG4122@1|root,COG4122@2|Bacteria,2IP3G@201174|Actinobacteria	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
TLS2_k127_4483332_19	561175.KB894093_gene3271	9.567e-106	363.0	COG1216@1|root,COG1216@2|Bacteria,2IBX4@201174|Actinobacteria,4EH9E@85012|Streptosporangiales	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_4483332_35	1033730.CAHG01000015_gene853	1.871e-53	210.0	COG0463@1|root,COG0463@2|Bacteria,2I4J0@201174|Actinobacteria,4DWHK@85009|Propionibacteriales	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	DUF3880,Glyco_trans_1_2,Glycos_transf_2
TLS2_k127_4483332_7	1869.MB27_01350	2.354e-183	582.0	COG0677@1|root,COG0677@2|Bacteria,2GK5K@201174|Actinobacteria,4DC0I@85008|Micromonosporales	201174|Actinobacteria	M	UDP binding domain	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS2_k127_4483332_18	263358.VAB18032_15210	3.876e-120	391.0	COG1215@1|root,COG1215@2|Bacteria,2IBMN@201174|Actinobacteria,4DB5Q@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_11
TLS2_k127_4483332_6	263358.VAB18032_15215	1.969e-185	584.0	COG0451@1|root,COG0451@2|Bacteria,2I9T0@201174|Actinobacteria,4DA9R@85008|Micromonosporales	201174|Actinobacteria	GM	GDP-mannose 4,6 dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_4483332_32	397278.JOJN01000022_gene3723	1.208e-56	221.0	28MYD@1|root,2ZB59@2|Bacteria,2GMV7@201174|Actinobacteria	201174|Actinobacteria	S	cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases	aftA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016757,GO:0016758,GO:0022607,GO:0030312,GO:0034645,GO:0035250,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071766,GO:0071769,GO:0071840,GO:0071944,GO:1901576	2.4.2.46	ko:K13686	-	-	-	-	ko00000,ko01000,ko01003	-	GT85	-	AftA_C,AftA_N
TLS2_k127_4483332_24	345341.KUTG_06859	1.101e-89	300.0	COG2318@1|root,COG2318@2|Bacteria,2I1DJ@201174|Actinobacteria,4E3VZ@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
TLS2_k127_4483332_33	326424.FRAAL1491	7.082e-54	207.0	COG1396@1|root,COG1396@2|Bacteria,2GP8T@201174|Actinobacteria	201174|Actinobacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
TLS2_k127_4483332_13	1449346.JQMO01000003_gene5636	3.092e-141	460.0	COG1087@1|root,COG1087@2|Bacteria,2GMCW@201174|Actinobacteria,2M4RS@2063|Kitasatospora	201174|Actinobacteria	M	Polysaccharide biosynthesis protein	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS2_k127_4483332_30	1246995.AFR_34685	2.866e-61	221.0	COG0558@1|root,COG0558@2|Bacteria,2GJVQ@201174|Actinobacteria,4DHRD@85008|Micromonosporales	201174|Actinobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
TLS2_k127_4483332_28	263358.VAB18032_09190	2.95e-71	248.0	COG1246@1|root,COG1246@2|Bacteria,2GJBT@201174|Actinobacteria,4DBNK@85008|Micromonosporales	201174|Actinobacteria	E	Acetyltransferase (GNAT) domain	argA	GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
TLS2_k127_4483332_26	1150864.MILUP08_40985	7.484e-79	266.0	COG1507@1|root,COG1507@2|Bacteria,2I8CS@201174|Actinobacteria,4DCTN@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF501)	-	-	-	ko:K09009	-	-	-	-	ko00000	-	-	-	DUF501
TLS2_k127_4483332_38	644283.Micau_0891	3.92e-26	115.0	COG2919@1|root,COG2919@2|Bacteria,2GQH7@201174|Actinobacteria,4DD7A@85008|Micromonosporales	201174|Actinobacteria	D	Septum formation initiator	divIC	-	-	ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
TLS2_k127_4483332_3	1464048.JNZS01000004_gene1254	1.279e-221	692.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,4DAAR@85008|Micromonosporales	201174|Actinobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TLS2_k127_4483332_34	644283.Micau_0342	1.001e-53	200.0	COG1672@1|root,COG1672@2|Bacteria,2GMAZ@201174|Actinobacteria,4DB60@85008|Micromonosporales	201174|Actinobacteria	S	PFAM Archaeal ATPase	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	ATPase_2,DUF234,HTH_5
TLS2_k127_4483332_41	1206739.BAGJ01000263_gene1562	1.551e-07	58.0	COG1672@1|root,COG1672@2|Bacteria,2GMAZ@201174|Actinobacteria,4G01U@85025|Nocardiaceae	201174|Actinobacteria	S	PFAM Archaeal ATPase	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	ATPase_2,DUF234
TLS2_k127_4483332_17	33876.JNXY01000006_gene939	5.583e-127	414.0	COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria,4DA35@85008|Micromonosporales	201174|Actinobacteria	S	MazG nucleotide pyrophosphohydrolase domain	mazG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0042454,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0047693,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
TLS2_k127_4483332_0	935839.JAGJ01000029_gene13	0.0	1361.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4F3R5@85017|Promicromonosporaceae	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS2_k127_4483332_16	1120950.KB892709_gene4138	1.837e-129	421.0	COG0494@1|root,COG1670@1|root,COG0494@2|Bacteria,COG1670@2|Bacteria,2IGFH@201174|Actinobacteria,4DTN8@85009|Propionibacteriales	201174|Actinobacteria	JL	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,NUDIX
TLS2_k127_4483332_37	2074.JNYD01000003_gene3407	1.199e-33	133.0	COG1487@1|root,COG1487@2|Bacteria,2IR5C@201174|Actinobacteria	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_4483332_1	219305.MCAG_03711	0.0	1326.0	COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria,4DA3C@85008|Micromonosporales	201174|Actinobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
TLS2_k127_4499888_1	298653.Franean1_4360	0.0	1558.0	COG0515@1|root,COG2199@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,2IBPU@201174|Actinobacteria,4EU2Z@85013|Frankiales	201174|Actinobacteria	KLT	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_3,GGDEF,Guanylate_cyc,HisKA_3,Pkinase
TLS2_k127_4499888_6	1463881.KL591030_gene2946	1.368e-53	205.0	28MY8@1|root,2ZB54@2|Bacteria,2GMYY@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4499888_0	391037.Sare_3613	0.0	1600.0	COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria,4DABZ@85008|Micromonosporales	201174|Actinobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0004739,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016624,GO:0016903,GO:0030312,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046872,GO:0055114,GO:0071944,GO:1902494,GO:1990204	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS2_k127_4499888_3	1150864.MILUP08_45370	2.89e-69	239.0	COG0432@1|root,COG0432@2|Bacteria,2IHWS@201174|Actinobacteria,4DDGY@85008|Micromonosporales	201174|Actinobacteria	S	Uncharacterised protein family UPF0047	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	UPF0047
TLS2_k127_4499888_4	1121946.AUAX01000001_gene2228	1.346e-66	229.0	2B57P@1|root,31Y1M@2|Bacteria,2IFRB@201174|Actinobacteria,4DCSX@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3052)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3052
TLS2_k127_4499888_2	1464048.JNZS01000009_gene5881	2.044e-72	250.0	COG1514@1|root,COG1514@2|Bacteria,2IKSA@201174|Actinobacteria,4DER1@85008|Micromonosporales	201174|Actinobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
TLS2_k127_4499888_7	1211815.CBYP010000015_gene2698	6.711e-28	126.0	COG0739@1|root,COG0739@2|Bacteria,2GKXN@201174|Actinobacteria,4EX4C@85013|Frankiales	201174|Actinobacteria	M	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,Peptidase_M23
TLS2_k127_4499888_5	1120949.KB903312_gene593	2.368e-66	229.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4DB2V@85008|Micromonosporales	201174|Actinobacteria	L	Transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_4554104_2	1121946.AUAX01000001_gene2342	1.846e-146	473.0	COG0415@1|root,COG0415@2|Bacteria,2GJXU@201174|Actinobacteria,4D8MY@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the DNA photolyase family	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
TLS2_k127_4554104_15	1121946.AUAX01000002_gene382	4.848e-32	136.0	arCOG05416@1|root,33310@2|Bacteria,2IQR4@201174|Actinobacteria,4DMX2@85008|Micromonosporales	201174|Actinobacteria	S	lycopene cyclase	crtYc	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4554104_16	1121946.AUAX01000002_gene383	1.307e-30	124.0	2E9MI@1|root,333U6@2|Bacteria,2IMX9@201174|Actinobacteria,4DG5M@85008|Micromonosporales	201174|Actinobacteria	S	lycopene cyclase	crtYd	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4554104_11	1121946.AUAX01000002_gene384	6.324e-62	220.0	COG0204@1|root,COG0204@2|Bacteria,2ISI3@201174|Actinobacteria,4DJ8Y@85008|Micromonosporales	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TLS2_k127_4554104_4	390989.JOEG01000028_gene5523	6.498e-130	425.0	COG1215@1|root,COG1215@2|Bacteria,2GJZI@201174|Actinobacteria,4DC9V@85008|Micromonosporales	201174|Actinobacteria	M	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_transf_21,Glycos_transf_2
TLS2_k127_4554104_3	1121946.AUAX01000002_gene386	2.66e-145	471.0	COG2124@1|root,COG2124@2|Bacteria,2I8CJ@201174|Actinobacteria,4DIER@85008|Micromonosporales	201174|Actinobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_4554104_12	1121272.KB903290_gene4650	1.226e-61	217.0	COG0517@1|root,COG0517@2|Bacteria,2IM3K@201174|Actinobacteria,4DEGD@85008|Micromonosporales	201174|Actinobacteria	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_4554104_9	35754.JNYJ01000069_gene4212	5.955e-74	254.0	COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria	201174|Actinobacteria	Q	phosphoribosyltransferase	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
TLS2_k127_4554104_6	263358.VAB18032_00680	1.211e-102	345.0	COG1316@1|root,COG1316@2|Bacteria,2I9WG@201174|Actinobacteria,4D9QT@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
TLS2_k127_4554104_13	479432.Sros_4831	1.939e-49	193.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4EJCN@85012|Streptosporangiales	201174|Actinobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_4554104_1	1122182.KB903814_gene3536	4.205e-252	800.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4DBNX@85008|Micromonosporales	201174|Actinobacteria	P	E1-E2 ATPase	ctpE	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
TLS2_k127_4554104_7	35754.JNYJ01000069_gene4210	3.27e-86	295.0	COG0778@1|root,COG0778@2|Bacteria,2I8P3@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_4554104_0	35754.JNYJ01000026_gene8794	0.0	1226.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4DBFP@85008|Micromonosporales	201174|Actinobacteria	G	Glycosyl hydrolase family 65, N-terminal domain	otsB1	GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0030312,GO:0044464,GO:0071944	3.1.3.12,3.2.1.28	ko:K01087,ko:K01194	ko00500,ko01100,map00500,map01100	-	R00010,R02778	RC00017,RC00049	ko00000,ko00001,ko00537,ko01000	-	GH37	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase,Trehalose_PPase
TLS2_k127_4554104_8	345341.KUTG_01091	5.935e-77	261.0	COG0748@1|root,COG0748@2|Bacteria,2IFHD@201174|Actinobacteria,4E4JA@85010|Pseudonocardiales	201174|Actinobacteria	P	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_4554104_14	756067.MicvaDRAFT_2820	4.652e-34	147.0	COG0823@1|root,COG2931@1|root,COG0823@2|Bacteria,COG2931@2|Bacteria,1G554@1117|Cyanobacteria,1HF7I@1150|Oscillatoriales	1117|Cyanobacteria	QU	PFAM Haemolysin-type calcium-binding repeat	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,PD40
TLS2_k127_4554104_10	68170.KL590483_gene5673	2.526e-62	243.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_4554104_17	103733.JNYO01000001_gene29	3.274e-10	74.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,4E16G@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_4554104_5	263358.VAB18032_18405	4.232e-103	344.0	28HG7@1|root,2Z7S3@2|Bacteria,2GMJK@201174|Actinobacteria,4DC3N@85008|Micromonosporales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	ko:K21167	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002	-	-	-	MDMPI_N,Wyosine_form
TLS2_k127_4647041_10	219305.MCAG_04663	1.214e-129	434.0	COG1887@1|root,COG1887@2|Bacteria,2H6EP@201174|Actinobacteria,4DBXE@85008|Micromonosporales	201174|Actinobacteria	M	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyphos_transf
TLS2_k127_4647041_12	1246995.AFR_02400	4.362e-127	417.0	COG0438@1|root,COG0438@2|Bacteria,2GJBP@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Stealth_CR1,Stealth_CR2,Stealth_CR3,Stealth_CR4
TLS2_k127_4647041_4	471852.Tcur_2984	8.132e-180	586.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Abhydrolase_1,GerE,Trans_reg_C
TLS2_k127_4647041_11	391037.Sare_0368	2.321e-127	435.0	COG1404@1|root,COG3055@1|root,COG1404@2|Bacteria,COG3055@2|Bacteria,2IF2T@201174|Actinobacteria,4DBYG@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Kelch_1,Peptidase_S8
TLS2_k127_4647041_28	397278.JOJN01000012_gene2144	3.431e-05	57.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4DP00@85009|Propionibacteriales	201174|Actinobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Laminin_G_3,Malectin,PKD
TLS2_k127_4647041_14	1156844.KB891820_gene435	1.437e-98	344.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	bpr	GO:0005575,GO:0005576	-	ko:K13276	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Inhibitor_I9,Malectin,PKD,Peptidase_M6,Peptidase_S8
TLS2_k127_4647041_6	33876.JNXY01000033_gene2081	6.607e-148	474.0	COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4D8XR@85008|Micromonosporales	201174|Actinobacteria	H	Belongs to the ribF family	ribF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
TLS2_k127_4647041_20	5759.rna_EHI_156240-1	3.614e-44	183.0	2D6RI@1|root,2T2RS@2759|Eukaryota,3XC2S@554915|Amoebozoa	554915|Amoebozoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4647041_27	1500890.JQNL01000001_gene3113	9.573e-22	111.0	COG2374@1|root,COG2374@2|Bacteria,1MX52@1224|Proteobacteria,1RRGN@1236|Gammaproteobacteria,1X3H2@135614|Xanthomonadales	135614|Xanthomonadales	Q	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,LTD
TLS2_k127_4647041_21	446466.Cfla_1517	9.59e-40	150.0	COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4F2MF@85016|Cellulomonadaceae	201174|Actinobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
TLS2_k127_4647041_0	35754.JNYJ01000005_gene5480	0.0	1238.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4DB4K@85008|Micromonosporales	201174|Actinobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TLS2_k127_4647041_3	644283.Micau_1484	6.647e-188	595.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4D8I3@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the peptidase M16 family	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_4647041_25	285535.JOEY01000002_gene5040	9.793e-31	134.0	2E7XW@1|root,332CB@2|Bacteria,2IT67@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4647041_15	1123320.KB889573_gene5491	1.762e-89	313.0	COG0845@1|root,COG0845@2|Bacteria,2HD6N@201174|Actinobacteria	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,PG_binding_1
TLS2_k127_4647041_16	1463895.JODA01000016_gene6349	4.858e-86	291.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4647041_8	1123320.KB889573_gene5493	6.108e-141	462.0	COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_4647041_13	391037.Sare_1341	1.665e-120	395.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,4D8IW@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2773c	DapB_C,DapB_N
TLS2_k127_4647041_17	1136417.AZWE01000025_gene750	5.646e-76	258.0	COG1247@1|root,COG1247@2|Bacteria,2II4R@201174|Actinobacteria,4DCAJ@85008|Micromonosporales	201174|Actinobacteria	M	Gcn5-related n-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_4647041_23	263358.VAB18032_12035	3.764e-35	140.0	COG1247@1|root,COG1247@2|Bacteria,2GR9D@201174|Actinobacteria,4DMPC@85008|Micromonosporales	201174|Actinobacteria	M	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_4647041_5	1464048.JNZS01000025_gene780	2.329e-178	569.0	COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria,4DA91@85008|Micromonosporales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
TLS2_k127_4647041_18	134676.ACPL_7196	1.735e-55	205.0	2E37T@1|root,33408@2|Bacteria,2HKTY@201174|Actinobacteria,4DD6B@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
TLS2_k127_4647041_24	405948.SACE_3262	3.123e-34	145.0	COG3595@1|root,COG3595@2|Bacteria,2GJZC@201174|Actinobacteria,4E0KS@85010|Pseudonocardiales	201174|Actinobacteria	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_4647041_19	1121946.AUAX01000034_gene6818	5.543e-50	183.0	COG4226@1|root,COG4226@2|Bacteria,2IKXB@201174|Actinobacteria,4DED5@85008|Micromonosporales	201174|Actinobacteria	S	protein encoded in hypervariable junctions of pilus gene clusters	-	-	-	-	-	-	-	-	-	-	-	-	Arc,HicB
TLS2_k127_4647041_9	1121946.AUAX01000034_gene6817	2.566e-133	432.0	COG1351@1|root,COG1351@2|Bacteria,2HCNJ@201174|Actinobacteria,4DBXM@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	GO:0000166,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0036094,GO:0040007,GO:0042083,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050797,GO:0070402,GO:0097159,GO:1901265,GO:1901363	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	iNJ661.Rv2754c	Thy1
TLS2_k127_4647041_7	134676.ACPL_7195	1.144e-142	457.0	COG0329@1|root,COG0329@2|Bacteria,2GJ34@201174|Actinobacteria,4DB5W@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_4647041_2	1150864.MILUP08_41584	7.159e-314	974.0	COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,4DCFB@85008|Micromonosporales	201174|Actinobacteria	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
TLS2_k127_4647041_22	875328.JDM601_0584	3.205e-37	148.0	COG1848@1|root,COG1848@2|Bacteria,2GSA4@201174|Actinobacteria,23DXX@1762|Mycobacteriaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_4647041_26	875328.JDM601_0583	6.061e-23	100.0	2ERR5@1|root,33JAC@2|Bacteria,2H116@201174|Actinobacteria,23EAS@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4647041_1	1121946.AUAX01000034_gene6814	1.131e-315	998.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,4D9AJ@85008|Micromonosporales	201174|Actinobacteria	D	DNA segregation ATPase FtsK SpoIIIE and related proteins	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TLS2_k127_4650526_2	263358.VAB18032_11560	5.82e-181	570.0	COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria,4DA22@85008|Micromonosporales	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TLS2_k127_4650526_1	391037.Sare_1189	7.937e-315	979.0	COG2844@1|root,COG2844@2|Bacteria,2GMKT@201174|Actinobacteria,4DBJP@85008|Micromonosporales	201174|Actinobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
TLS2_k127_4650526_7	1121272.KB903272_gene318	1.412e-59	212.0	COG0347@1|root,COG0347@2|Bacteria,2IKN1@201174|Actinobacteria,4DDPU@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the P(II) protein family	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
TLS2_k127_4650526_3	369723.Strop_1298	6.135e-162	522.0	COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,4D9EI@85008|Micromonosporales	201174|Actinobacteria	P	ammonium transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TLS2_k127_4650526_5	1121946.AUAX01000014_gene1063	1.254e-153	490.0	COG2334@1|root,COG2334@2|Bacteria,2I2JR@201174|Actinobacteria,4D9XM@85008|Micromonosporales	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_4650526_4	263358.VAB18032_11535	4.876e-158	506.0	COG0552@1|root,COG0552@2|Bacteria,2GJQH@201174|Actinobacteria,4D9IH@85008|Micromonosporales	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
TLS2_k127_4650526_0	644283.Micau_1366	0.0	1511.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4DAP3@85008|Micromonosporales	201174|Actinobacteria	D	Required for chromosome condensation and partitioning	smc	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
TLS2_k127_4650526_9	369723.Strop_1290	7.618e-30	122.0	2ENN7@1|root,33G9I@2|Bacteria,2IQG5@201174|Actinobacteria,4DFIU@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4650526_8	1122611.KB903953_gene5727	4.913e-41	161.0	COG2340@1|root,COG2340@2|Bacteria,2GM57@201174|Actinobacteria,4EQSF@85012|Streptosporangiales	201174|Actinobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
TLS2_k127_4650526_6	35754.JNYJ01000038_gene4885	3.958e-60	220.0	COG0438@1|root,COG0438@2|Bacteria,2GKEA@201174|Actinobacteria,4DAPC@85008|Micromonosporales	201174|Actinobacteria	M	Domain of unknown function (DUF3492)	-	-	-	ko:K21011	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	DUF3492,Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_4650788_20	2045.KR76_23355	2.096e-39	163.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM,SPASM
TLS2_k127_4650788_28	1380390.JIAT01000009_gene668	1.732e-15	88.0	2CDM0@1|root,33HR7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4650788_10	263358.VAB18032_11355	2.656e-88	302.0	COG0204@1|root,COG0204@2|Bacteria,2GKVA@201174|Actinobacteria,4DARQ@85008|Micromonosporales	201174|Actinobacteria	I	Acyltransferase	plsC2	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_4650788_4	644283.Micau_1337	9.911e-143	467.0	COG0240@1|root,COG0240@2|Bacteria,2GJSD@201174|Actinobacteria,4DAAJ@85008|Micromonosporales	201174|Actinobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
TLS2_k127_4650788_2	219305.MCAG_04229	2.17e-175	556.0	COG0626@1|root,COG0626@2|Bacteria,2GMD8@201174|Actinobacteria,4D8DU@85008|Micromonosporales	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	cysA	-	4.4.1.1	ko:K01758	ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230	M00338	R00782,R01001,R02408,R04770,R04930,R09366	RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
TLS2_k127_4650788_17	1123393.KB891316_gene1821	1.578e-63	227.0	COG0500@1|root,COG2226@2|Bacteria,1PECT@1224|Proteobacteria,2VYBR@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_4650788_16	1246448.ANAZ01000048_gene3280	2.811e-64	233.0	COG2267@1|root,COG2267@2|Bacteria,2GJUE@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_4650788_5	1108045.GORHZ_085_00220	2.807e-141	466.0	COG2197@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,4GAJV@85026|Gordoniaceae	201174|Actinobacteria	K	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HD,HD_5
TLS2_k127_4650788_6	1089549.AZUQ01000001_gene2235	6.215e-141	461.0	COG2239@1|root,COG2239@2|Bacteria,2GMMK@201174|Actinobacteria,4EY2U@85014|Glycomycetales	201174|Actinobacteria	P	MgtE intracellular N domain	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N,PRC
TLS2_k127_4650788_3	1464048.JNZS01000017_gene3658	8.625e-174	552.0	COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria,4D9CT@85008|Micromonosporales	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TLS2_k127_4650788_22	369723.Strop_1273	1.485e-34	144.0	2CQFE@1|root,32SM3@2|Bacteria,2IHCI@201174|Actinobacteria,4DD4V@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3515)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3515
TLS2_k127_4650788_25	1122182.KB903833_gene5365	2.67e-28	125.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria,4DF46@85008|Micromonosporales	201174|Actinobacteria	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
TLS2_k127_4650788_7	263358.VAB18032_11410	2.325e-136	440.0	COG0611@1|root,COG0611@2|Bacteria,2GP6E@201174|Actinobacteria,4DADB@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0008150,GO:0040007	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2977c	AIRS,AIRS_C
TLS2_k127_4650788_11	37919.EP51_04860	4.613e-83	286.0	COG0500@1|root,COG2226@2|Bacteria,2GM2N@201174|Actinobacteria,4FX7V@85025|Nocardiaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_4650788_14	644283.Micau_1426	3.576e-69	241.0	COG1733@1|root,COG1733@2|Bacteria,2GMK5@201174|Actinobacteria,4DB8G@85008|Micromonosporales	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR,SCP2
TLS2_k127_4650788_18	263358.VAB18032_11415	4.165e-58	208.0	COG0454@1|root,COG0456@2|Bacteria,2IFF2@201174|Actinobacteria,4DD0M@85008|Micromonosporales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_4650788_24	33876.JNXY01000027_gene3656	6.161e-29	116.0	COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria,4DF4U@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
TLS2_k127_4650788_1	644283.Micau_1351	1.035e-194	622.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4D8DT@85008|Micromonosporales	201174|Actinobacteria	S	Dak phosphatase	dak3	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
TLS2_k127_4650788_0	219305.MCAG_04242	3.715e-305	955.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4DCGD@85008|Micromonosporales	201174|Actinobacteria	L	helicase	recG	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge,tRNA_anti-codon
TLS2_k127_4650788_30	1869.MB27_22965	7.132e-10	69.0	COG3266@1|root,COG3266@2|Bacteria,2IKR0@201174|Actinobacteria,4DE2I@85008|Micromonosporales	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Gram_pos_anchor
TLS2_k127_4650788_27	391037.Sare_1170	1.338e-17	94.0	COG3266@1|root,COG3266@2|Bacteria,2IKR0@201174|Actinobacteria,4DE2I@85008|Micromonosporales	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Gram_pos_anchor
TLS2_k127_4650788_19	405948.SACE_6107	1.067e-48	182.0	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4E45R@85010|Pseudonocardiales	201174|Actinobacteria	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
TLS2_k127_4650788_13	1150864.MILUP08_41440	7.126e-78	263.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4DCXA@85008|Micromonosporales	201174|Actinobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_4650788_15	1121946.AUAX01000014_gene1077	1.111e-67	233.0	COG0711@1|root,COG0711@2|Bacteria,2GNBF@201174|Actinobacteria,4D920@85008|Micromonosporales	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4650788_12	1150864.MILUP08_41442	2.428e-78	266.0	COG1399@1|root,COG1399@2|Bacteria,2GJTS@201174|Actinobacteria,4DCHR@85008|Micromonosporales	201174|Actinobacteria	S	Uncharacterized ACR, COG1399	-	GO:0008150,GO:0040007	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
TLS2_k127_4650788_26	219305.MCAG_04247	1.353e-23	100.0	COG0333@1|root,COG0333@2|Bacteria,2GQP3@201174|Actinobacteria,4DFJS@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
TLS2_k127_4650788_9	35754.JNYJ01000005_gene5384	7.466e-113	370.0	COG0571@1|root,COG0571@2|Bacteria,2GKER@201174|Actinobacteria,4DA1J@85008|Micromonosporales	201174|Actinobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
TLS2_k127_4650788_8	263358.VAB18032_11480	2.576e-126	412.0	COG0266@1|root,COG0266@2|Bacteria,2GJNT@201174|Actinobacteria,4D8YM@85008|Micromonosporales	201174|Actinobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034039,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_4650788_21	1121272.KB903272_gene306	2.395e-39	168.0	COG1122@1|root,COG1122@2|Bacteria,2GK4F@201174|Actinobacteria,4DEWH@85008|Micromonosporales	201174|Actinobacteria	P	Spherulation-specific family 4	-	-	-	-	-	-	-	-	-	-	-	-	Spherulin4
TLS2_k127_4650788_23	1869.MB27_36955	1.916e-32	142.0	295NZ@1|root,2ZT0C@2|Bacteria,2HUN8@201174|Actinobacteria,4DFIK@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4650788_29	1246995.AFR_36500	1.636e-12	70.0	COG0438@1|root,COG0438@2|Bacteria,2H5HZ@201174|Actinobacteria,4DJ9X@85008|Micromonosporales	201174|Actinobacteria	M	Domain of unknown function (DUF3492)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3492,Glyco_trans_1_4
TLS2_k127_4689847_1	1032480.MLP_18870	7.516e-152	484.0	COG3267@1|root,COG3267@2|Bacteria,2IA4V@201174|Actinobacteria	201174|Actinobacteria	U	Type II secretory pathway component ExeA	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
TLS2_k127_4689847_0	1032480.MLP_18840	3.814e-243	760.0	COG2801@1|root,COG2801@2|Bacteria,2GJ3V@201174|Actinobacteria,4DSTQ@85009|Propionibacteriales	201174|Actinobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,HTH_32,LZ_Tnp_IS481,rve,rve_3
TLS2_k127_4689847_2	1032480.MLP_18830	1.492e-80	273.0	COG3677@1|root,COG3677@2|Bacteria,2IGIB@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4689847_3	2002.JOEQ01000033_gene1688	9.6e-16	80.0	COG0346@1|root,COG0346@2|Bacteria,2IM0I@201174|Actinobacteria,4ENRH@85012|Streptosporangiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,Glyoxalase_4
TLS2_k127_4695854_99	219305.MCAG_03158	2.701e-27	113.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,4D9PJ@85008|Micromonosporales	201174|Actinobacteria	L	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD_C_2
TLS2_k127_4695854_106	1121272.KB903283_gene5126	3.269e-07	53.0	COG3173@1|root,COG3173@2|Bacteria,2IA48@201174|Actinobacteria	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_4695854_89	1122182.KB903825_gene398	9.489e-39	150.0	COG1393@1|root,COG1393@2|Bacteria,2IHRP@201174|Actinobacteria,4DK55@85008|Micromonosporales	201174|Actinobacteria	P	ArsC family	arsC	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
TLS2_k127_4695854_31	1123024.AUII01000019_gene3982	4.322e-133	450.0	COG3266@1|root,COG3266@2|Bacteria,2I44K@201174|Actinobacteria,4DZUJ@85010|Pseudonocardiales	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4695854_19	369723.Strop_3500	1.673e-177	569.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,4D9U9@85008|Micromonosporales	201174|Actinobacteria	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
TLS2_k127_4695854_47	391037.Sare_3878	2.177e-106	347.0	COG0740@1|root,COG0740@2|Bacteria,2GK5C@201174|Actinobacteria,4D907@85008|Micromonosporales	201174|Actinobacteria	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TLS2_k127_4695854_44	35754.JNYJ01000065_gene5673	8.079e-110	359.0	COG0740@1|root,COG0740@2|Bacteria,2GKNK@201174|Actinobacteria,4D8CY@85008|Micromonosporales	201174|Actinobacteria	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TLS2_k127_4695854_12	219305.MCAG_01583	1.581e-234	731.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,4DA2P@85008|Micromonosporales	201174|Actinobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
TLS2_k127_4695854_103	298654.FraEuI1c_1909	3.202e-18	91.0	2DR8X@1|root,33AQM@2|Bacteria,2GXTC@201174|Actinobacteria,4EWM3@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4695854_92	1120948.KB903218_gene1718	3.175e-36	144.0	COG4113@1|root,COG4113@2|Bacteria,2GR4U@201174|Actinobacteria,4E7I2@85010|Pseudonocardiales	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_4695854_69	1121272.KB903251_gene914	2.493e-75	259.0	COG1396@1|root,COG1396@2|Bacteria,2GXAS@201174|Actinobacteria,4DDM1@85008|Micromonosporales	201174|Actinobacteria	K	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,HTH_31
TLS2_k127_4695854_68	644283.Micau_4908	1.52e-75	263.0	COG0697@1|root,COG0697@2|Bacteria,2GM50@201174|Actinobacteria,4DDPM@85008|Micromonosporales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_4695854_32	1150864.MILUP08_45687	2.144e-131	423.0	COG0388@1|root,COG0388@2|Bacteria,2GMQA@201174|Actinobacteria,4D9TE@85008|Micromonosporales	201174|Actinobacteria	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
TLS2_k127_4695854_107	35754.JNYJ01000065_gene5669	1.563e-06	53.0	2BJHM@1|root,32DUG@2|Bacteria,2GYT6@201174|Actinobacteria,4DGJW@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4695854_1	649831.L083_1506	0.0	1446.0	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4DBFY@85008|Micromonosporales	201174|Actinobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TLS2_k127_4695854_15	1121272.KB903258_gene5409	1.146e-207	656.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4D95V@85008|Micromonosporales	201174|Actinobacteria	H	Belongs to the folylpolyglutamate synthase family	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2447c	Mur_ligase_C,Mur_ligase_M
TLS2_k127_4695854_71	369723.Strop_3490	8.225e-71	256.0	COG0346@1|root,COG0346@2|Bacteria,2IC4P@201174|Actinobacteria,4D8RA@85008|Micromonosporales	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_4695854_74	1869.MB27_19600	1.047e-64	225.0	COG0105@1|root,COG0105@2|Bacteria,2IFBU@201174|Actinobacteria,4DDFU@85008|Micromonosporales	201174|Actinobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	iNJ661.Rv2445c	NDK
TLS2_k127_4695854_0	263358.VAB18032_28546	0.0	1680.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4D973@85008|Micromonosporales	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
TLS2_k127_4695854_37	1173028.ANKO01000106_gene318	1.972e-123	411.0	COG1192@1|root,COG1192@2|Bacteria,1G2GG@1117|Cyanobacteria,1H9IU@1150|Oscillatoriales	1117|Cyanobacteria	D	CobQ CobB MinD ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
TLS2_k127_4695854_105	345341.KUTG_06504	1.431e-07	60.0	COG2865@1|root,COG2865@2|Bacteria,2GZ30@201174|Actinobacteria,4E8KF@85010|Pseudonocardiales	201174|Actinobacteria	K	Putative DNA-binding domain	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
TLS2_k127_4695854_88	345341.KUTG_06504	1.087e-41	164.0	COG2865@1|root,COG2865@2|Bacteria,2GZ30@201174|Actinobacteria,4E8KF@85010|Pseudonocardiales	201174|Actinobacteria	K	Putative DNA-binding domain	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
TLS2_k127_4695854_98	1123399.AQVE01000016_gene2755	1.5e-27	115.0	COG2865@1|root,COG2865@2|Bacteria,1R4MD@1224|Proteobacteria,1RQTX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_24
TLS2_k127_4695854_23	1121272.KB903249_gene1368	1.165e-163	552.0	COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	ko:K07114,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	HemolysinCabind
TLS2_k127_4695854_41	1122247.C731_4072	2.683e-113	376.0	COG1575@1|root,COG1575@2|Bacteria,2IPQ8@201174|Actinobacteria,23E29@1762|Mycobacteriaceae	201174|Actinobacteria	H	Belongs to the MenA family. Type 1 subfamily	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
TLS2_k127_4695854_108	696747.NIES39_O01840	5.08e-06	54.0	COG4374@1|root,COG4374@2|Bacteria,1GAZM@1117|Cyanobacteria,1HDJV@1150|Oscillatoriales	1117|Cyanobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_4695854_63	192952.MM_2650	5.323e-83	284.0	COG0596@1|root,arCOG01648@2157|Archaea,2Y06J@28890|Euryarchaeota,2N9YM@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS2_k127_4695854_3	391037.Sare_3863	0.0	1185.0	COG1032@1|root,COG1032@2|Bacteria,2GJY1@201174|Actinobacteria,4DA3H@85008|Micromonosporales	201174|Actinobacteria	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_4695854_48	263358.VAB18032_28521	6.221e-106	349.0	COG5011@1|root,COG5011@2|Bacteria,2GIS7@201174|Actinobacteria,4D989@85008|Micromonosporales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2344)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344
TLS2_k127_4695854_9	1464048.JNZS01000023_gene2590	2.124e-277	884.0	COG1530@1|root,COG1530@2|Bacteria,2GMM5@201174|Actinobacteria,4DAJS@85008|Micromonosporales	201174|Actinobacteria	J	Ribonuclease E/G family	rne	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	IF2_N,RNase_E_G,S1
TLS2_k127_4695854_83	1121272.KB903258_gene5396	4.188e-48	179.0	COG0261@1|root,COG0261@2|Bacteria,2IQ9A@201174|Actinobacteria,4DE6G@85008|Micromonosporales	201174|Actinobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
TLS2_k127_4695854_91	391037.Sare_3859	4.649e-37	143.0	COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4DF9N@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
TLS2_k127_4695854_13	263358.VAB18032_28501	6.193e-231	725.0	COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,4D9WG@85008|Micromonosporales	201174|Actinobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
TLS2_k127_4695854_43	1120949.KB903305_gene7073	2.29e-110	375.0	COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria,4D8Q6@85008|Micromonosporales	201174|Actinobacteria	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS2_k127_4695854_77	469371.Tbis_1077	1.656e-59	216.0	COG2003@1|root,COG2003@2|Bacteria,2IJG2@201174|Actinobacteria,4ECTG@85010|Pseudonocardiales	201174|Actinobacteria	L	RadC-like JAB domain	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
TLS2_k127_4695854_7	710111.FraQA3DRAFT_3382	2.613e-292	919.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4ES10@85013|Frankiales	201174|Actinobacteria	E	PFAM Peptidase M1, membrane alanine aminopeptidase	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
TLS2_k127_4695854_55	219305.MCAG_01552	9.348e-100	328.0	COG1057@1|root,COG1057@2|Bacteria,2GMFZ@201174|Actinobacteria,4D8E6@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_4695854_79	644283.Micau_4873	3.903e-56	199.0	COG0799@1|root,COG0799@2|Bacteria,2IKZ3@201174|Actinobacteria,4DDCU@85008|Micromonosporales	201174|Actinobacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
TLS2_k127_4695854_76	1464048.JNZS01000023_gene2569	1.941e-63	225.0	COG0406@1|root,COG0406@2|Bacteria,2GJYU@201174|Actinobacteria,4D9Y8@85008|Micromonosporales	201174|Actinobacteria	G	phosphoglycerate mutase	gpmB	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237	3.1.3.85,5.4.2.11	ko:K01834,ko:K22306	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
TLS2_k127_4695854_104	1122182.KB903833_gene5623	7.088e-17	89.0	2EI21@1|root,33BTI@2|Bacteria,2GZFC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4695854_56	644283.Micau_4871	1.269e-97	327.0	COG1307@1|root,COG1307@2|Bacteria,2GIUV@201174|Actinobacteria,4D9BR@85008|Micromonosporales	201174|Actinobacteria	S	Uncharacterised protein, DegV family COG1307	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DegV
TLS2_k127_4695854_80	1464048.JNZS01000023_gene2565	3.055e-55	203.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4DDIY@85008|Micromonosporales	201174|Actinobacteria	L	competence protein ComEA helix-hairpin-helix repeat protein	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
TLS2_k127_4695854_11	356851.JOAN01000031_gene5260	3.42e-254	806.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4DAIV@85008|Micromonosporales	201174|Actinobacteria	S	DNA internalization-related competence protein ComEC Rec2	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
TLS2_k127_4695854_4	1121272.KB903252_gene1050	0.0	1019.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4DAAM@85008|Micromonosporales	201174|Actinobacteria	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_4695854_29	263358.VAB18032_28431	2.399e-134	437.0	COG1466@1|root,COG1466@2|Bacteria,2GNMZ@201174|Actinobacteria,4D9VX@85008|Micromonosporales	201174|Actinobacteria	L	DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
TLS2_k127_4695854_101	1120949.KB903305_gene7086	1.964e-21	100.0	2BZX9@1|root,2ZCSV@2|Bacteria,2GTKY@201174|Actinobacteria,4DER6@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4695854_96	219305.MCAG_01544	4.973e-32	126.0	COG0268@1|root,COG0268@2|Bacteria,2IQ73@201174|Actinobacteria,4DF07@85008|Micromonosporales	201174|Actinobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
TLS2_k127_4695854_6	469371.Tbis_1146	4.953e-315	973.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4DX6U@85010|Pseudonocardiales	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
TLS2_k127_4695854_61	219305.MCAG_01534	3.306e-86	294.0	COG0739@1|root,COG0739@2|Bacteria,2GKXN@201174|Actinobacteria,4DBNH@85008|Micromonosporales	201174|Actinobacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4695854_54	1120949.KB903305_gene7095	1.122e-100	334.0	COG1024@1|root,COG1024@2|Bacteria,2GJ0N@201174|Actinobacteria,4D9QW@85008|Micromonosporales	201174|Actinobacteria	I	enoyl-CoA hydratase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_4695854_18	263358.VAB18032_28381	5.766e-178	576.0	COG0635@1|root,COG0635@2|Bacteria,2GJXX@201174|Actinobacteria,4D8JA@85008|Micromonosporales	201174|Actinobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	iNJ661.Rv2388c	HemN_C,Radical_SAM
TLS2_k127_4695854_86	1150864.MILUP08_45613	2.23e-44	166.0	COG3296@1|root,COG3296@2|Bacteria,2IQSV@201174|Actinobacteria,4DEWZ@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4870)	-	-	-	ko:K09940	-	-	-	-	ko00000	-	-	-	DUF4870
TLS2_k127_4695854_22	649831.L083_1557	2.573e-169	538.0	COG1420@1|root,COG1420@2|Bacteria,2GKF5@201174|Actinobacteria,4D8HR@85008|Micromonosporales	201174|Actinobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA
TLS2_k127_4695854_16	1121946.AUAX01000009_gene4536	8.795e-201	630.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,4D8DG@85008|Micromonosporales	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_4695854_59	219305.MCAG_01528	5.763e-91	305.0	COG1385@1|root,COG1385@2|Bacteria,2GTKX@201174|Actinobacteria,4D9Y9@85008|Micromonosporales	201174|Actinobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
TLS2_k127_4695854_28	1121272.KB903250_gene3133	6.03e-142	456.0	COG1737@1|root,COG1737@2|Bacteria,2HY2W@201174|Actinobacteria,4DBJ5@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator, rpir family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
TLS2_k127_4695854_40	345341.KUTG_06551	1.956e-114	385.0	COG1653@1|root,COG1653@2|Bacteria,2GJM5@201174|Actinobacteria,4E0TY@85010|Pseudonocardiales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10200	ko02010,map02010	M00205	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.18	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_4695854_45	391037.Sare_3206	1.057e-107	358.0	COG1175@1|root,COG1175@2|Bacteria,2GJZD@201174|Actinobacteria,4D93V@85008|Micromonosporales	201174|Actinobacteria	G	transport systems	ngcF	-	-	ko:K10201	ko02010,map02010	M00205	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.18	-	-	BPD_transp_1
TLS2_k127_4695854_38	345341.KUTG_06553	1.563e-118	388.0	COG0395@1|root,COG0395@2|Bacteria,2GNQW@201174|Actinobacteria,4DYKZ@85010|Pseudonocardiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	ngcG	-	-	ko:K02026,ko:K10119,ko:K10202	ko02010,map02010	M00196,M00205,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.18,3.A.1.1.28	-	-	BPD_transp_1
TLS2_k127_4695854_85	33876.JNXY01000007_gene8297	9.285e-47	172.0	COG0537@1|root,COG0537@2|Bacteria,2IHPT@201174|Actinobacteria,4DEAE@85008|Micromonosporales	201174|Actinobacteria	FG	Histidine triad (HIT) protein	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
TLS2_k127_4695854_21	35754.JNYJ01000043_gene4560	2.385e-172	550.0	COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria,4DC9N@85008|Micromonosporales	201174|Actinobacteria	T	PhoH-like protein	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
TLS2_k127_4695854_70	33876.JNXY01000007_gene8289	2.661e-73	252.0	COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4DCVM@85008|Micromonosporales	201174|Actinobacteria	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
TLS2_k127_4695854_20	391037.Sare_3830	6.757e-177	566.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4D8JR@85008|Micromonosporales	201174|Actinobacteria	S	Hemolysins and related proteins containing CBS domains	corC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_4695854_90	543632.JOJL01000018_gene9060	9.731e-38	146.0	COG0295@1|root,COG0295@2|Bacteria,2IM42@201174|Actinobacteria,4DEC2@85008|Micromonosporales	201174|Actinobacteria	F	cytidine deaminase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4695854_26	644283.Micau_4842	2.23e-152	487.0	COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria,4D9EW@85008|Micromonosporales	201174|Actinobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
TLS2_k127_4695854_82	1380356.JNIK01000011_gene1782	8.009e-49	180.0	COG1595@1|root,COG1595@2|Bacteria,2GN5Y@201174|Actinobacteria,4ESZT@85013|Frankiales	201174|Actinobacteria	K	sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_4695854_39	391037.Sare_3826	1.843e-117	383.0	COG1381@1|root,COG1381@2|Bacteria,2GK81@201174|Actinobacteria,4DAK5@85008|Micromonosporales	201174|Actinobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
TLS2_k127_4695854_30	263358.VAB18032_28301	3.778e-134	432.0	COG0020@1|root,COG0020@2|Bacteria,2GIXF@201174|Actinobacteria,4DB6H@85008|Micromonosporales	201174|Actinobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.86,2.5.1.88	ko:K00806,ko:K14215,ko:K21273	ko00900,ko01110,map00900,map01110	-	R06447,R09244,R09731	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS2_k127_4695854_35	263358.VAB18032_28271	4.049e-124	410.0	COG0701@1|root,COG0701@2|Bacteria,2GJQ0@201174|Actinobacteria,4D9HD@85008|Micromonosporales	201174|Actinobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
TLS2_k127_4695854_66	263358.VAB18032_28266	4.778e-77	280.0	COG3689@1|root,COG3689@2|Bacteria,2GNFK@201174|Actinobacteria,4DAJW@85008|Micromonosporales	201174|Actinobacteria	S	membrane	-	-	-	ko:K08986	-	-	-	-	ko00000	-	-	-	DUF1980
TLS2_k127_4695854_42	1121946.AUAX01000009_gene4397	3.41e-112	373.0	COG5632@1|root,COG5632@2|Bacteria,2I3UE@201174|Actinobacteria,4DMVK@85008|Micromonosporales	201174|Actinobacteria	M	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
TLS2_k127_4695854_53	1150864.MILUP08_45588	2.286e-101	336.0	COG2267@1|root,COG2267@2|Bacteria,2I2IM@201174|Actinobacteria,4D8NX@85008|Micromonosporales	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_4695854_5	219305.MCAG_01505	3.985e-318	985.0	COG1960@1|root,COG1960@2|Bacteria,2GKK9@201174|Actinobacteria,4DB5R@85008|Micromonosporales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	fadE10	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
TLS2_k127_4695854_27	529884.Rhola_00011660	3.884e-147	497.0	COG1132@1|root,COG1132@2|Bacteria,2GJTA@201174|Actinobacteria,4FM09@85023|Microbacteriaceae	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_4695854_33	391037.Sare_2448	1.494e-130	432.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4DIF3@85008|Micromonosporales	201174|Actinobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_4695854_75	1068980.ARVW01000001_gene7271	1.345e-63	227.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4E939@85010|Pseudonocardiales	201174|Actinobacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC5,BTAD,HTH_3,NB-ARC,TPR_10,TPR_12,TPR_7,Trans_reg_C
TLS2_k127_4695854_72	356851.JOAN01000031_gene5311	1.812e-67	232.0	COG0735@1|root,COG0735@2|Bacteria,2IKS3@201174|Actinobacteria,4DDB2@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the Fur family	furB	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_4695854_87	1136417.AZWE01000043_gene3216	1.158e-42	160.0	COG0640@1|root,COG0640@2|Bacteria,2IMSD@201174|Actinobacteria,4DF3A@85008|Micromonosporales	201174|Actinobacteria	K	transcriptional	smtB	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0044212,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K22298	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
TLS2_k127_4695854_52	263358.VAB18032_28231	8.185e-104	347.0	COG1108@1|root,COG1108@2|Bacteria,2GJ7H@201174|Actinobacteria,4D91V@85008|Micromonosporales	201174|Actinobacteria	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
TLS2_k127_4695854_57	644283.Micau_4822	1.104e-96	323.0	COG1121@1|root,COG1121@2|Bacteria,2GP3A@201174|Actinobacteria,4DM26@85008|Micromonosporales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	mntB	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
TLS2_k127_4695854_49	263358.VAB18032_28221	8.707e-106	357.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,4D9QD@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	scbA	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
TLS2_k127_4695854_95	1136417.AZWE01000043_gene3221	3.419e-32	141.0	COG2329@1|root,COG2329@2|Bacteria,2GQZB@201174|Actinobacteria,4DEM3@85008|Micromonosporales	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS2_k127_4695854_100	369723.Strop_3434	8.558e-27	118.0	2BG8S@1|root,2ZT8H@2|Bacteria,2IJ4M@201174|Actinobacteria,4DM9H@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4695854_10	369723.Strop_3433	3.996e-270	837.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,4DBAM@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
TLS2_k127_4695854_62	134676.ACPL_8253	1.282e-85	286.0	COG1881@1|root,COG1881@2|Bacteria,2GMIG@201174|Actinobacteria,4DC75@85008|Micromonosporales	201174|Actinobacteria	S	Phospholipid-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
TLS2_k127_4695854_102	644283.Micau_3293	8.32e-20	97.0	COG3764@1|root,COG3764@2|Bacteria,2I91T@201174|Actinobacteria,4DCS8@85008|Micromonosporales	201174|Actinobacteria	M	peptidase C60 sortase A and B	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
TLS2_k127_4695854_2	351607.Acel_0801	0.0	1360.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4ERQZ@85013|Frankiales	201174|Actinobacteria	G	pyruvate phosphate dikinase, PEP	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS2_k127_4695854_93	649831.L083_7749	3.38e-33	132.0	COG2044@1|root,COG2044@2|Bacteria,2IHT6@201174|Actinobacteria,4DDC3@85008|Micromonosporales	201174|Actinobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
TLS2_k127_4695854_34	326424.FRAAL6340	2.214e-125	432.0	COG2319@1|root,COG3629@1|root,COG2319@2|Bacteria,COG3629@2|Bacteria,2GJN3@201174|Actinobacteria,4EUR9@85013|Frankiales	201174|Actinobacteria	P	WD-40 repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,NACHT,Pentapeptide,Pkinase,TIR_2,WD40
TLS2_k127_4695854_51	1214101.BN159_0449	6.33e-105	364.0	COG1075@1|root,COG1075@2|Bacteria,2I090@201174|Actinobacteria	201174|Actinobacteria	S	Lecithin:cholesterol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	LCAT
TLS2_k127_4695854_36	1214101.BN159_0448	8.73e-124	421.0	COG0507@1|root,COG0507@2|Bacteria,2I698@201174|Actinobacteria	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4695854_46	1869.MB27_06605	8.64e-107	351.0	COG1794@1|root,COG1794@2|Bacteria,2H7J9@201174|Actinobacteria,4DGAV@85008|Micromonosporales	201174|Actinobacteria	M	Asp/Glu/Hydantoin racemase	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
TLS2_k127_4695854_65	1206744.BAGL01000013_gene5990	1.324e-80	278.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_4695854_73	1996.JOFO01000028_gene5988	2.053e-66	239.0	COG1045@1|root,COG1045@2|Bacteria,2IHW5@201174|Actinobacteria,4EQ4R@85012|Streptosporangiales	201174|Actinobacteria	E	Bacterial transferase hexapeptide (six repeats)	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
TLS2_k127_4695854_64	105425.BBPL01000064_gene5296	8.898e-82	287.0	COG1168@1|root,COG1168@2|Bacteria,2GJFQ@201174|Actinobacteria,2NI72@228398|Streptacidiphilus	201174|Actinobacteria	E	Aminotransferase class I and II	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_4695854_58	1996.JOFO01000028_gene5989	1.775e-96	337.0	COG2232@1|root,COG2232@2|Bacteria,2HPI0@201174|Actinobacteria	201174|Actinobacteria	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
TLS2_k127_4695854_50	1869.MB27_06605	1.017e-105	349.0	COG1794@1|root,COG1794@2|Bacteria,2H7J9@201174|Actinobacteria,4DGAV@85008|Micromonosporales	201174|Actinobacteria	M	Asp/Glu/Hydantoin racemase	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
TLS2_k127_4695854_14	35754.JNYJ01000013_gene1088	7.753e-222	730.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4D8IM@85008|Micromonosporales	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,HTH_31,NB-ARC,TPR_12,TPR_7,Trans_reg_C
TLS2_k127_4695854_17	219305.MCAG_01487	8.822e-185	589.0	COG0232@1|root,COG0232@2|Bacteria,2GJ8F@201174|Actinobacteria,4DAZ8@85008|Micromonosporales	201174|Actinobacteria	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
TLS2_k127_4695854_25	35754.JNYJ01000043_gene4509	5.992e-158	509.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4DB8Z@85008|Micromonosporales	201174|Actinobacteria	S	Reductase C-terminal	fprD	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
TLS2_k127_4695854_78	1463887.KL589953_gene277	7.104e-58	215.0	COG0524@1|root,COG0524@2|Bacteria,2GYHF@201174|Actinobacteria	201174|Actinobacteria	G	PfkB family	pfkB	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS2_k127_4695854_8	644283.Micau_4804	4.426e-289	899.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4D9J8@85008|Micromonosporales	201174|Actinobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
TLS2_k127_4695854_84	1869.MB27_19165	7.245e-48	179.0	2EFFR@1|root,3398G@2|Bacteria,2I2V9@201174|Actinobacteria,4DMDG@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4695854_24	1120949.KB903305_gene7174	5.236e-163	517.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DAC8@85008|Micromonosporales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	nodI	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
TLS2_k127_4695854_67	1246995.AFR_08185	5.77e-76	271.0	COG0842@1|root,COG0842@2|Bacteria,2GVC2@201174|Actinobacteria,4DCGV@85008|Micromonosporales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
TLS2_k127_4695854_60	1869.MB27_19150	2.671e-89	301.0	COG0842@1|root,COG0842@2|Bacteria,2GMXR@201174|Actinobacteria,4DBPU@85008|Micromonosporales	201174|Actinobacteria	V	Transport permease protein	nodJ	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
TLS2_k127_4695854_97	263358.VAB18032_28031	3.05e-28	122.0	2DRKZ@1|root,33C8D@2|Bacteria,2GWR3@201174|Actinobacteria,4DE17@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4695854_81	35754.JNYJ01000014_gene4712	6.973e-50	184.0	COG0664@1|root,COG0664@2|Bacteria,2IRJW@201174|Actinobacteria,4DF04@85008|Micromonosporales	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
TLS2_k127_4698037_26	35754.JNYJ01000075_gene8659	1.191e-77	268.0	2E80S@1|root,332EZ@2|Bacteria,2H37J@201174|Actinobacteria	201174|Actinobacteria	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4698037_46	419947.MRA_2783	1.132e-05	51.0	COG5450@1|root,COG5450@2|Bacteria	2|Bacteria	K	positive regulation of growth	-	GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
TLS2_k127_4698037_35	1206729.BAFZ01000107_gene442	4.792e-29	123.0	COG1487@1|root,COG1487@2|Bacteria,2GPT6@201174|Actinobacteria,4G9CZ@85025|Nocardiaceae	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_4698037_45	298654.FraEuI1c_1852	1.333e-08	56.0	COG1373@1|root,COG1373@2|Bacteria,2GK1Q@201174|Actinobacteria	201174|Actinobacteria	J	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
TLS2_k127_4698037_44	298654.FraEuI1c_1853	1.872e-09	62.0	COG4683@1|root,COG4683@2|Bacteria,2IQAB@201174|Actinobacteria	201174|Actinobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
TLS2_k127_4698037_34	1120797.KB908259_gene928	7.29e-32	131.0	COG1487@1|root,COG1487@2|Bacteria,2IN9Z@201174|Actinobacteria,23AA7@1762|Mycobacteriaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_4698037_29	37919.EP51_12380	7.055e-64	224.0	COG1695@1|root,COG1695@2|Bacteria,2IJQK@201174|Actinobacteria,4FZRQ@85025|Nocardiaceae	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_4698037_28	42256.RradSPS_2880	3.747e-72	252.0	2DIEU@1|root,3030N@2|Bacteria,2H9Y7@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
TLS2_k127_4698037_25	1394178.AWOO02000002_gene1691	4.941e-79	275.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_4698037_15	1869.MB27_33290	4.995e-115	377.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria,4DENR@85008|Micromonosporales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_4698037_20	593907.Celgi_1113	2.05e-108	374.0	COG2385@1|root,COG5479@1|root,COG2385@2|Bacteria,COG5479@2|Bacteria,2GNDB@201174|Actinobacteria,4F2JD@85016|Cellulomonadaceae	201174|Actinobacteria	DM	Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme.	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,FG-GAP
TLS2_k127_4698037_33	591158.SSMG_04310	2.51e-32	134.0	COG0239@1|root,COG0239@2|Bacteria,2IKM1@201174|Actinobacteria	201174|Actinobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB1	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TLS2_k127_4698037_36	1122611.KB904018_gene7029	4.384e-27	121.0	COG0239@1|root,COG0239@2|Bacteria,2IKWG@201174|Actinobacteria,4EJX5@85012|Streptosporangiales	201174|Actinobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB1	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TLS2_k127_4698037_3	1120949.KB903296_gene9540	1.533e-272	849.0	COG0028@1|root,COG0028@2|Bacteria,2GJ20@201174|Actinobacteria,4D9PN@85008|Micromonosporales	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	1.2.3.3,1.2.5.1	ko:K00156,ko:K00158	ko00620,ko01100,map00620,map01100	-	R00207,R03145	RC00860,RC02745	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_4698037_30	391037.Sare_4036	1.516e-57	217.0	COG0515@1|root,COG0515@2|Bacteria,2GTP2@201174|Actinobacteria,4D8MW@85008|Micromonosporales	201174|Actinobacteria	KLT	Protein of unknown function (DUF3105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3105
TLS2_k127_4698037_11	1463845.JOIG01000002_gene2482	4.743e-128	430.0	COG0614@1|root,COG0614@2|Bacteria,2GM6R@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS2_k127_4698037_0	103733.JNYO01000020_gene1915	0.0	1552.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4DZN7@85010|Pseudonocardiales	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	-	ko:K12955	-	-	-	-	ko00000,ko01000	3.A.3.24	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
TLS2_k127_4698037_8	446470.Snas_6397	1.142e-173	563.0	COG3325@1|root,COG3325@2|Bacteria,2GJGW@201174|Actinobacteria,4EYHP@85014|Glycomycetales	201174|Actinobacteria	G	Glyco_18	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_5_12,Glyco_hydro_18
TLS2_k127_4698037_39	1463856.JOHY01000016_gene5631	1.052e-20	107.0	COG3979@1|root,COG3979@2|Bacteria,2I2XD@201174|Actinobacteria	201174|Actinobacteria	G	chitin binding	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_5_12
TLS2_k127_4698037_40	749927.AMED_6675	5.053e-18	98.0	COG3525@1|root,COG3979@1|root,COG3525@2|Bacteria,COG3979@2|Bacteria,2H28J@201174|Actinobacteria,4DYKQ@85010|Pseudonocardiales	201174|Actinobacteria	G	Glycosyl hydrolase family 20, domain 2	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	Glyco_hydro_20,Glyco_hydro_20b
TLS2_k127_4698037_47	224914.BMEI0620	2.588e-05	55.0	2EE5H@1|root,33801@2|Bacteria,1NFKZ@1224|Proteobacteria,2UIVJ@28211|Alphaproteobacteria,1J2Z8@118882|Brucellaceae	28211|Alphaproteobacteria	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
TLS2_k127_4698037_27	219305.MCAG_03323	5.961e-73	252.0	COG0412@1|root,COG0412@2|Bacteria,2I37P@201174|Actinobacteria,4DCSE@85008|Micromonosporales	201174|Actinobacteria	Q	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS2_k127_4698037_48	1142394.PSMK_16790	2.871e-05	54.0	COG1196@1|root,COG1196@2|Bacteria,2J17X@203682|Planctomycetes	203682|Planctomycetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4698037_17	443218.AS9A_1202	1.024e-112	374.0	COG0226@1|root,COG0226@2|Bacteria,2HNK6@201174|Actinobacteria,23DHM@1762|Mycobacteriaceae	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
TLS2_k127_4698037_14	443218.AS9A_1203	6.005e-119	395.0	COG0573@1|root,COG0573@2|Bacteria,2IDRE@201174|Actinobacteria,23DPG@1762|Mycobacteriaceae	201174|Actinobacteria	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS2_k127_4698037_23	1246445.ANAY01000029_gene4511	3.573e-83	291.0	COG0581@1|root,COG0581@2|Bacteria,2IBYS@201174|Actinobacteria,4EQUZ@85012|Streptosporangiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS2_k127_4698037_12	1121926.AXWO01000035_gene4027	8.9e-127	413.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4EXWB@85014|Glycomycetales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TLS2_k127_4698037_50	1127134.NOCYR_0496	0.0001318	46.0	COG1487@1|root,COG1487@2|Bacteria,2IMGJ@201174|Actinobacteria,4G1NY@85025|Nocardiaceae	201174|Actinobacteria	S	PIN domain	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_4698037_38	1127134.NOCYR_0497	2.128e-23	101.0	2ESJQ@1|root,33K4C@2|Bacteria,2I83J@201174|Actinobacteria	201174|Actinobacteria	S	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
TLS2_k127_4698037_41	110319.CF8_3293	7.876e-18	93.0	COG0704@1|root,COG0704@2|Bacteria,2GKAD@201174|Actinobacteria,4DQEB@85009|Propionibacteriales	201174|Actinobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TLS2_k127_4698037_13	469383.Cwoe_4495	1.795e-122	399.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4CP9Q@84995|Rubrobacteria	84995|Rubrobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	-	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TLS2_k127_4698037_19	469383.Cwoe_4494	6.203e-109	361.0	COG0581@1|root,COG0581@2|Bacteria,2I2F2@201174|Actinobacteria,4CQ28@84995|Rubrobacteria	84995|Rubrobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS2_k127_4698037_18	1137268.AZXF01000038_gene4056	6.866e-110	363.0	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria,4EN85@85012|Streptosporangiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS2_k127_4698037_16	1137268.AZXF01000038_gene4057	7.66e-113	373.0	COG0226@1|root,COG0226@2|Bacteria,2GMY1@201174|Actinobacteria,4EN38@85012|Streptosporangiales	201174|Actinobacteria	P	PBP superfamily domain	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	HSP70,PBP_like,PBP_like_2
TLS2_k127_4698037_31	1464048.JNZS01000002_gene377	1.139e-52	195.0	COG0494@1|root,COG0494@2|Bacteria,2GN6D@201174|Actinobacteria,4D9RT@85008|Micromonosporales	201174|Actinobacteria	L	Nudix hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_4698037_7	390989.JOEG01000022_gene2326	3.426e-174	554.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4D9J7@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_4698037_22	219305.MCAG_02298	2.416e-100	330.0	COG1392@1|root,COG1392@2|Bacteria,2GJME@201174|Actinobacteria,4D8MA@85008|Micromonosporales	201174|Actinobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
TLS2_k127_4698037_24	263358.VAB18032_02185	3.139e-79	267.0	COG3557@1|root,COG3557@2|Bacteria,2IQ8M@201174|Actinobacteria,4DCQR@85008|Micromonosporales	201174|Actinobacteria	J	domain protein associated with RNAses G and E	-	-	-	ko:K07586	-	-	-	-	ko00000	-	-	-	DUF402
TLS2_k127_4698037_1	263358.VAB18032_02190	2.39e-307	956.0	COG1199@1|root,COG1199@2|Bacteria,2GKT8@201174|Actinobacteria,4DAC9@85008|Micromonosporales	201174|Actinobacteria	KL	HELICc2	dinG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
TLS2_k127_4698037_21	1120949.KB903306_gene7564	5.891e-101	344.0	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,4D9PZ@85008|Micromonosporales	201174|Actinobacteria	S	AI-2E family transporter	-	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K20469	-	-	-	-	ko00000,ko02000	2.A.86.1.7	-	-	AI-2E_transport
TLS2_k127_4698037_32	33876.JNXY01000019_gene7656	9.487e-46	186.0	COG0234@1|root,COG0234@2|Bacteria,2IHRC@201174|Actinobacteria,4DE0Q@85008|Micromonosporales	201174|Actinobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groES2	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TLS2_k127_4698037_9	369723.Strop_0276	3.069e-151	492.0	COG2339@1|root,COG2339@2|Bacteria,2GKR5@201174|Actinobacteria,4D9P7@85008|Micromonosporales	201174|Actinobacteria	K	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
TLS2_k127_4698037_6	644283.Micau_5744	3.563e-212	667.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4DAMJ@85008|Micromonosporales	201174|Actinobacteria	C	Fad linked oxidase	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_4698037_10	479434.Sthe_2747	2.38e-149	485.0	COG0624@1|root,COG0624@2|Bacteria,2G62C@200795|Chloroflexi,27XWR@189775|Thermomicrobia	2|Bacteria	E	peptidase M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_4698037_4	543632.JOJL01000031_gene6201	8.904e-242	762.0	COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,4D9HB@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TLS2_k127_4698037_5	1464048.JNZS01000002_gene396	1.346e-237	758.0	COG1404@1|root,COG1404@2|Bacteria,2I8MD@201174|Actinobacteria,4DBMJ@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,SLH
TLS2_k127_4698037_43	471853.Bcav_0244	8.841e-12	76.0	2FEXV@1|root,346WK@2|Bacteria,2GVWC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4698037_49	471853.Bcav_0244	3.448e-05	53.0	2FEXV@1|root,346WK@2|Bacteria,2GVWC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4698037_2	263358.VAB18032_02265	1.677e-283	876.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4D901@85008|Micromonosporales	201174|Actinobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL1	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS2_k127_4723612_0	1150864.MILUP08_45022	3.922e-225	710.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4D8KQ@85008|Micromonosporales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	tdcA	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS2_k127_4723612_4	1121272.KB903293_gene7036	6.225e-61	213.0	COG1959@1|root,COG1959@2|Bacteria,2INF3@201174|Actinobacteria,4DCQF@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
TLS2_k127_4723612_5	1150864.MILUP08_45185	0.0003865	49.0	2BEEH@1|root,3285P@2|Bacteria,2HDXM@201174|Actinobacteria,4DKTK@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4723612_3	391037.Sare_3384	2.036e-159	511.0	COG1946@1|root,COG1946@2|Bacteria,2GJ1B@201174|Actinobacteria,4D8YK@85008|Micromonosporales	201174|Actinobacteria	I	Acyl-CoA thioesterase	tesB	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
TLS2_k127_4723612_1	644283.Micau_4402	2.523e-219	689.0	COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria,4D8Y5@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the pyruvate kinase family	pyk	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
TLS2_k127_4723612_2	1304865.JAGF01000001_gene3151	1.272e-174	559.0	COG0477@1|root,COG2814@2|Bacteria,2I2IS@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_4741305_12	263358.VAB18032_11675	1.937e-124	402.0	COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4DAY2@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS2_k127_4741305_17	1136417.AZWE01000035_gene450	1.09e-88	295.0	COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4D8FH@85008|Micromonosporales	201174|Actinobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
TLS2_k127_4741305_16	1464048.JNZS01000017_gene3591	2.918e-91	311.0	COG0575@1|root,COG0575@2|Bacteria,2I7ZA@201174|Actinobacteria,4DBJT@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TLS2_k127_4741305_7	1150864.MILUP08_41507	1.104e-177	564.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4D9P5@85008|Micromonosporales	201174|Actinobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
TLS2_k127_4741305_19	369723.Strop_1328	1.053e-70	254.0	COG3599@1|root,COG3599@2|Bacteria,2IBU8@201174|Actinobacteria,4D8KS@85008|Micromonosporales	201174|Actinobacteria	D	regulation of cell shape	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4741305_32	1246995.AFR_36185	2.571e-12	70.0	2CAUA@1|root,2ZVDD@2|Bacteria,2GRRY@201174|Actinobacteria,4DFSU@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF2631)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2631
TLS2_k127_4741305_1	263358.VAB18032_11705	1.324e-281	872.0	COG2146@1|root,COG2220@1|root,COG2146@2|Bacteria,COG2220@2|Bacteria,2GP4N@201174|Actinobacteria,4DBJI@85008|Micromonosporales	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	ko:K14952	ko05152,map05152	-	-	-	ko00000,ko00001	-	-	-	Lactamase_B_3,Rieske
TLS2_k127_4741305_21	1122622.ATWJ01000014_gene367	2.339e-61	227.0	COG3550@1|root,COG3550@2|Bacteria,2I2QD@201174|Actinobacteria,4FG8P@85021|Intrasporangiaceae	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
TLS2_k127_4741305_31	1056816.JAFQ01000004_gene1139	1.659e-20	93.0	2DSKC@1|root,33GGZ@2|Bacteria,2GZG5@201174|Actinobacteria,4G3GT@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	ko:K21495	-	-	-	-	ko00000,ko02048	-	-	-	-
TLS2_k127_4741305_25	1206739.BAGJ01000267_gene2973	5.027e-38	147.0	COG4113@1|root,COG4113@2|Bacteria,2HM5M@201174|Actinobacteria,4G55W@85025|Nocardiaceae	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_4741305_33	1121924.ATWH01000005_gene2792	6.944e-11	66.0	COG3177@1|root,COG3177@2|Bacteria,2IAAQ@201174|Actinobacteria	201174|Actinobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
TLS2_k127_4741305_26	446466.Cfla_2034	1.82e-31	124.0	COG3177@1|root,COG3177@2|Bacteria,2IAAQ@201174|Actinobacteria	201174|Actinobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
TLS2_k127_4741305_2	1150864.MILUP08_41514	7.183e-261	811.0	COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,4DB0E@85008|Micromonosporales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS2_k127_4741305_5	35754.JNYJ01000005_gene5440	9.172e-187	591.0	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria,4DB4Y@85008|Micromonosporales	201174|Actinobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2870c	DXPR_C,DXP_redisom_C,DXP_reductoisom
TLS2_k127_4741305_9	33876.JNXY01000027_gene3584	4.744e-154	497.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4DAZD@85008|Micromonosporales	201174|Actinobacteria	M	Peptidase family M50	rip1	GO:0008150,GO:0040007	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
TLS2_k127_4741305_3	369723.Strop_1352	2.758e-207	649.0	COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,4D9J3@85008|Micromonosporales	201174|Actinobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TLS2_k127_4741305_8	644283.Micau_1454	1.815e-160	509.0	COG0024@1|root,COG0024@2|Bacteria,2GKIZ@201174|Actinobacteria,4D8HP@85008|Micromonosporales	201174|Actinobacteria	E	Methionine aminopeptidase	map	GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS2_k127_4741305_4	35754.JNYJ01000009_gene1837	7.431e-189	631.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2GN24@201174|Actinobacteria,4DBTG@85008|Micromonosporales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
TLS2_k127_4741305_13	33876.JNXY01000016_gene6937	3.443e-109	360.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4DAEI@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4741305_18	219305.MCAG_04342	1.349e-85	287.0	COG1695@1|root,COG1695@2|Bacteria,2GNA1@201174|Actinobacteria,4DBZU@85008|Micromonosporales	201174|Actinobacteria	K	Virulence activator alpha C-term	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
TLS2_k127_4741305_27	219305.MCAG_04343	2.817e-31	139.0	2EA6A@1|root,334B4@2|Bacteria,2II4E@201174|Actinobacteria,4DEXV@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4439)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4439
TLS2_k127_4741305_30	33876.JNXY01000033_gene2065	4.228e-26	118.0	2C43R@1|root,2ZGVP@2|Bacteria,2IQE2@201174|Actinobacteria,4DF6A@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4741305_23	644283.Micau_1466	1.249e-55	203.0	COG0779@1|root,COG0779@2|Bacteria,2I9BT@201174|Actinobacteria,4DCXT@85008|Micromonosporales	201174|Actinobacteria	S	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
TLS2_k127_4741305_6	219305.MCAG_04346	5.282e-178	570.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4D8SJ@85008|Micromonosporales	201174|Actinobacteria	K	Participates in both transcription termination and antitermination	nusA	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
TLS2_k127_4741305_29	263358.VAB18032_11950	1.426e-27	121.0	COG2740@1|root,COG2740@2|Bacteria,2GQH0@201174|Actinobacteria,4DF9J@85008|Micromonosporales	201174|Actinobacteria	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
TLS2_k127_4741305_0	263358.VAB18032_11955	0.0	1292.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4D9SJ@85008|Micromonosporales	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
TLS2_k127_4741305_15	1120950.KB892823_gene572	2.13e-106	357.0	COG0116@1|root,COG0116@2|Bacteria,2I2EM@201174|Actinobacteria	201174|Actinobacteria	L	Putative RNA methylase family UPF0020	-	-	-	-	-	-	-	-	-	-	-	-	UPF0020
TLS2_k127_4741305_24	644283.Micau_1472	5.865e-43	160.0	COG1550@1|root,COG1550@2|Bacteria,2IQW4@201174|Actinobacteria,4DETR@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
TLS2_k127_4741305_22	356851.JOAN01000012_gene5186	9.484e-59	217.0	COG0858@1|root,COG0858@2|Bacteria,2IKXP@201174|Actinobacteria,4DDJ9@85008|Micromonosporales	201174|Actinobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
TLS2_k127_4741305_10	219305.MCAG_04351	1.503e-145	468.0	COG0618@1|root,COG0618@2|Bacteria,2GN9Z@201174|Actinobacteria,4D9W4@85008|Micromonosporales	201174|Actinobacteria	S	phosphoesterase RecJ domain protein	nrnA	GO:0008150,GO:0040007	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TLS2_k127_4741305_20	1121926.AXWO01000034_gene1952	3.693e-66	241.0	COG1075@1|root,COG1075@2|Bacteria,2HYYX@201174|Actinobacteria,4EXK3@85014|Glycomycetales	201174|Actinobacteria	S	Alpha/beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_8
TLS2_k127_4741305_28	1150864.MILUP08_41565	3.965e-31	137.0	2DFQ4@1|root,2ZSN2@2|Bacteria,2HUHM@201174|Actinobacteria,4DF27@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4741305_14	1123024.AUII01000011_gene4418	7.982e-108	362.0	COG1835@1|root,COG1835@2|Bacteria,2GN56@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS2_k127_4741305_11	1136417.AZWE01000025_gene756	6.442e-126	411.0	COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4D96B@85008|Micromonosporales	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C,TruB_C_2,TruB_N
TLS2_k127_4918831_7	1121272.KB903292_gene3704	9.957e-23	105.0	COG0030@1|root,COG0030@2|Bacteria,2H1TK@201174|Actinobacteria,4DC34@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family	-	-	2.1.1.184	ko:K00561	-	-	R10716	RC00003,RC03257	br01600,ko00000,ko01000,ko01504,ko03009	-	-	-	RrnaAD
TLS2_k127_4918831_6	1150864.MILUP08_42516	3.501e-71	244.0	COG1426@1|root,COG1426@2|Bacteria,2I2W5@201174|Actinobacteria,4DCQD@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
TLS2_k127_4918831_5	1150864.MILUP08_42517	1.572e-81	274.0	COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria,4DCQ9@85008|Micromonosporales	201174|Actinobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
TLS2_k127_4918831_3	35754.JNYJ01000001_gene7438	2.584e-164	522.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4D9N9@85008|Micromonosporales	201174|Actinobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_4918831_1	644283.Micau_2333	8.364e-224	713.0	COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,4D9CM@85008|Micromonosporales	201174|Actinobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS2_k127_4918831_2	1869.MB27_25760	2.37e-192	608.0	COG0505@1|root,COG0505@2|Bacteria,2GKFA@201174|Actinobacteria,4DAZB@85008|Micromonosporales	201174|Actinobacteria	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
TLS2_k127_4918831_0	33876.JNXY01000016_gene6950	0.0	1793.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4D8MS@85008|Micromonosporales	201174|Actinobacteria	F	Carbamoyl-phosphate synthetase ammonia chain	carB	GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS2_k127_4918831_4	450851.PHZ_c1121	2.694e-131	430.0	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,2TRQ1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
TLS2_k127_4947596_13	55952.BU52_16055	7.812e-48	175.0	COG1569@1|root,COG1569@2|Bacteria,2IMP1@201174|Actinobacteria	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
TLS2_k127_4947596_23	479432.Sros_8220	6.321e-11	67.0	COG1569@1|root,COG1569@2|Bacteria,2IMP1@201174|Actinobacteria,4EJUU@85012|Streptosporangiales	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
TLS2_k127_4947596_18	479432.Sros_8221	3.432e-40	154.0	COG3311@1|root,COG3311@2|Bacteria,2HZPA@201174|Actinobacteria,4EKVC@85012|Streptosporangiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
TLS2_k127_4947596_14	1449353.JQMQ01000004_gene6577	1.309e-47	171.0	2E0MI@1|root,32W6Q@2|Bacteria,2IQTZ@201174|Actinobacteria,2NMRT@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4947596_21	1120936.KB907213_gene4942	7.566e-29	117.0	COG3620@1|root,COG3620@2|Bacteria,2HH2D@201174|Actinobacteria,4EQ3T@85012|Streptosporangiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
TLS2_k127_4947596_16	1449976.KALB_75	5.318e-42	156.0	COG4683@1|root,COG4683@2|Bacteria,2IFY3@201174|Actinobacteria,4EB36@85010|Pseudonocardiales	201174|Actinobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
TLS2_k127_4947596_20	66377.JOBH01000025_gene3317	1.272e-30	128.0	COG3631@1|root,COG3631@2|Bacteria,2GT3G@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS2_k127_4947596_24	1150864.MILUP08_40637	6.013e-06	48.0	COG2152@1|root,COG2152@2|Bacteria,2HNS8@201174|Actinobacteria,4DA52@85008|Micromonosporales	201174|Actinobacteria	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
TLS2_k127_4947596_11	1283283.ATXA01000020_gene1307	1.721e-58	204.0	COG1695@1|root,COG1695@2|Bacteria,2IM8U@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
TLS2_k127_4947596_12	1283283.ATXA01000020_gene1308	4.34e-50	181.0	COG4817@1|root,COG4817@2|Bacteria,2IM9H@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1048)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1048
TLS2_k127_4947596_8	1429046.RR21198_2053	8.38e-124	414.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4FV76@85025|Nocardiaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4947596_7	1120959.ATXF01000005_gene1452	4.55e-124	401.0	COG0842@1|root,COG0842@2|Bacteria,2GIVW@201174|Actinobacteria,4FMB3@85023|Microbacteriaceae	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_4947596_17	263358.VAB18032_12685	9.213e-41	154.0	COG3324@1|root,COG3324@2|Bacteria,2I4XW@201174|Actinobacteria	201174|Actinobacteria	E	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4947596_0	298655.KI912266_gene2945	0.0	1432.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,4ES6Q@85013|Frankiales	201174|Actinobacteria	GT	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
TLS2_k127_4947596_15	1068978.AMETH_2556	7.044e-43	160.0	2C2H7@1|root,32Z8Q@2|Bacteria,2ITDR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS2_k127_4947596_10	1869.MB27_21545	5.118e-63	218.0	COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria,4DDC6@85008|Micromonosporales	201174|Actinobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS2_k127_4947596_4	649831.L083_5729	1.689e-181	578.0	COG0798@1|root,COG0798@2|Bacteria,2GJ4H@201174|Actinobacteria,4DAP2@85008|Micromonosporales	201174|Actinobacteria	P	Sodium Bile acid symporter family	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
TLS2_k127_4947596_19	1122182.KB903825_gene598	7.405e-33	132.0	COG0640@1|root,COG0640@2|Bacteria,2IKNB@201174|Actinobacteria,4DG8U@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
TLS2_k127_4947596_2	1366050.N234_25715	2.026e-193	617.0	COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2VH8B@28216|Betaproteobacteria,1K4Y9@119060|Burkholderiaceae	28216|Betaproteobacteria	I	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS2_k127_4947596_9	426117.M446_1338	2.354e-76	263.0	COG1024@1|root,COG1024@2|Bacteria,1RDWE@1224|Proteobacteria,2UA9Q@28211|Alphaproteobacteria,1JXC9@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_4947596_1	479432.Sros_6965	3.441e-198	627.0	COG1653@1|root,COG1653@2|Bacteria,2HP0P@201174|Actinobacteria,4EMTP@85012|Streptosporangiales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
TLS2_k127_4947596_3	1206101.AZXC01000040_gene2254	5.095e-190	599.0	COG0596@1|root,COG0596@2|Bacteria,2GK79@201174|Actinobacteria	201174|Actinobacteria	K	epoxide hydrolase	-	-	-	ko:K21159	ko01059,map01059	-	-	-	ko00000,ko00001	-	-	-	EHN
TLS2_k127_4947596_5	561175.KB894100_gene4770	5.437e-168	546.0	COG0500@1|root,COG2226@2|Bacteria,2GKW2@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_4947596_6	1068980.ARVW01000001_gene4921	1.701e-162	532.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4E9NB@85010|Pseudonocardiales	201174|Actinobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
TLS2_k127_4958700_11	35754.JNYJ01000011_gene659	5.436e-77	267.0	COG3903@1|root,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4DGXQ@85008|Micromonosporales	201174|Actinobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC5,BTAD,HTH_3,HTH_31,NB-ARC,TPR_10,TPR_12,TPR_7,TPR_8,Trans_reg_C
TLS2_k127_4958700_10	1122182.KB903826_gene941	1.661e-89	313.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4D9KA@85008|Micromonosporales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_4958700_8	1464048.JNZS01000024_gene870	5.383e-101	343.0	COG4585@1|root,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4D9SD@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_4958700_5	1206732.BAGD01000054_gene2007	3.15e-181	582.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4FU1D@85025|Nocardiaceae	201174|Actinobacteria	M	ABC transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_4958700_6	1169161.KB897737_gene2366	4.065e-154	491.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_4958700_13	1206726.BAFV01000018_gene1215	2.509e-49	186.0	COG1510@1|root,COG1510@2|Bacteria,2GNYV@201174|Actinobacteria,4G9WA@85025|Nocardiaceae	201174|Actinobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS2_k127_4958700_2	246197.MXAN_5836	1.045e-242	769.0	COG0339@1|root,COG0339@2|Bacteria,1R4AJ@1224|Proteobacteria,43BI1@68525|delta/epsilon subdivisions,2WMHM@28221|Deltaproteobacteria,2YUF2@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase family M3	prlC1	-	3.4.24.15	ko:K01392	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
TLS2_k127_4958700_0	644283.Micau_0652	0.0	1089.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4D8SC@85008|Micromonosporales	201174|Actinobacteria	C	ferredoxin oxidoreductase	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
TLS2_k127_4958700_4	356851.JOAN01000001_gene3628	2.888e-194	609.0	COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria,4DC7Q@85008|Micromonosporales	201174|Actinobacteria	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
TLS2_k127_4958700_1	263358.VAB18032_01735	0.0	1041.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4DBPZ@85008|Micromonosporales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
TLS2_k127_4958700_14	1150864.MILUP08_46450	2.375e-26	111.0	COG2331@1|root,COG2331@2|Bacteria,2GR6C@201174|Actinobacteria,4DG2K@85008|Micromonosporales	201174|Actinobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TLS2_k127_4958700_12	543632.JOJL01000058_gene9828	9.238e-70	254.0	COG0741@1|root,COG0741@2|Bacteria,2I2XS@201174|Actinobacteria,4DAXN@85008|Micromonosporales	201174|Actinobacteria	M	Membrane-bound lytic murein transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23,SLT_2
TLS2_k127_4958700_7	263358.VAB18032_01750	1.79e-121	400.0	COG0454@1|root,COG0456@2|Bacteria,2I8J8@201174|Actinobacteria,4DA4S@85008|Micromonosporales	201174|Actinobacteria	K	Gcn5-related n-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7,FR47
TLS2_k127_4958700_3	436229.JOEH01000015_gene5995	3.693e-229	737.0	COG0515@1|root,COG0515@2|Bacteria,2GMRN@201174|Actinobacteria,2NG5A@228398|Streptacidiphilus	201174|Actinobacteria	KLT	Lanthionine synthetase C-like protein	-	-	-	-	-	-	-	-	-	-	-	-	LANC_like,Pkinase
TLS2_k127_4958700_9	390989.JOEG01000030_gene1696	3.19e-94	318.0	COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria,4DC3C@85008|Micromonosporales	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
TLS2_k127_4972643_22	1150864.MILUP08_45709	1.136e-53	194.0	COG4636@1|root,COG4636@2|Bacteria,2GRIW@201174|Actinobacteria	201174|Actinobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS2_k127_4972643_1	356851.JOAN01000006_gene444	0.0	1173.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4DB3U@85008|Micromonosporales	201174|Actinobacteria	E	aminopeptidase N	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
TLS2_k127_4972643_12	356851.JOAN01000006_gene445	5.044e-94	312.0	COG2761@1|root,COG2761@2|Bacteria,2GJNX@201174|Actinobacteria,4D8HX@85008|Micromonosporales	201174|Actinobacteria	Q	DSBA oxidoreductase	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DSBA
TLS2_k127_4972643_8	1150864.MILUP08_45705	1.356e-159	516.0	COG4198@1|root,COG4198@2|Bacteria,2HTTT@201174|Actinobacteria,4D8D2@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
TLS2_k127_4972643_17	356851.JOAN01000006_gene448	2.087e-69	238.0	COG0698@1|root,COG0698@2|Bacteria,2GKJG@201174|Actinobacteria,4DCQE@85008|Micromonosporales	201174|Actinobacteria	G	Ribose 5-phosphate isomerase	rpiB	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005576,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2465c	LacAB_rpiB
TLS2_k127_4972643_28	263358.VAB18032_28676	1.159e-16	91.0	COG0515@1|root,COG0515@2|Bacteria,2I9DR@201174|Actinobacteria,4DD7C@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS2_k127_4972643_10	58123.JOFJ01000008_gene443	1.059e-118	392.0	COG1171@1|root,COG1171@2|Bacteria,2GKCC@201174|Actinobacteria,4EIEE@85012|Streptosporangiales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	tdcB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_4972643_20	1121272.KB903291_gene3407	3.144e-55	206.0	2E3YX@1|root,32YVV@2|Bacteria,2GTR4@201174|Actinobacteria,4DJ9A@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4972643_0	67352.JODS01000044_gene29	0.0	1549.0	COG2911@1|root,COG2931@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,2HPDD@201174|Actinobacteria	201174|Actinobacteria	Q	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
TLS2_k127_4972643_35	1410668.JNKC01000016_gene993	0.0001668	44.0	2DES4@1|root,2ZP1M@2|Bacteria,1W3CF@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4972643_13	1121272.KB903252_gene1058	3.262e-91	305.0	COG1073@1|root,COG1073@2|Bacteria,2GNUS@201174|Actinobacteria,4DD5U@85008|Micromonosporales	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
TLS2_k127_4972643_33	1194165.CAJF01000025_gene3276	1.324e-05	50.0	COG3903@1|root,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,DUF4062,NB-ARC,TPR_12
TLS2_k127_4972643_2	1121946.AUAX01000016_gene4708	0.0	1129.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,4D8NI@85008|Micromonosporales	201174|Actinobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
TLS2_k127_4972643_7	263358.VAB18032_13485	2.76e-186	595.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4D9U7@85008|Micromonosporales	201174|Actinobacteria	P	Sulfate permease family	-	GO:0000103,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008272,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0019001,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
TLS2_k127_4972643_6	1122611.KB903969_gene2392	7.164e-200	631.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,4EHEC@85012|Streptosporangiales	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
TLS2_k127_4972643_15	391037.Sare_2893	5.504e-76	265.0	COG2188@1|root,COG2188@2|Bacteria,2GKMH@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS2_k127_4972643_18	561175.KB894095_gene2181	1.78e-64	223.0	arCOG05626@1|root,32V4D@2|Bacteria,2I38M@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4972643_11	543632.JOJL01000004_gene3889	8.737e-109	357.0	COG1801@1|root,COG1801@2|Bacteria,2GMSP@201174|Actinobacteria,4D8XN@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS2_k127_4972643_19	1463820.JOGW01000003_gene7175	3.924e-57	209.0	COG0730@1|root,COG0730@2|Bacteria,2GPQV@201174|Actinobacteria	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
TLS2_k127_4972643_23	1121946.AUAX01000016_gene4819	1.3e-51	186.0	COG1917@1|root,COG1917@2|Bacteria,2IIQY@201174|Actinobacteria,4DEYR@85008|Micromonosporales	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_4972643_9	543632.JOJL01000004_gene3931	9.674e-126	434.0	COG4995@1|root,COG4995@2|Bacteria,2I4X0@201174|Actinobacteria	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
TLS2_k127_4972643_26	543632.JOJL01000004_gene3930	2.296e-19	93.0	2B2SW@1|root,31BZZ@2|Bacteria,2HAPQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4972643_5	1240349.ANGC01000004_gene1724	1.327e-267	845.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2GNII@201174|Actinobacteria,4FV1H@85025|Nocardiaceae	201174|Actinobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
TLS2_k127_4972643_3	1120949.KB903294_gene3820	1.493e-317	981.0	COG0204@1|root,COG0438@1|root,COG0204@2|Bacteria,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	cmk	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase,Glyco_transf_4,Glycos_transf_1
TLS2_k127_4972643_14	1246474.ANBE01000011_gene3694	1.486e-89	302.0	COG0783@1|root,COG0783@2|Bacteria,2HTPH@201174|Actinobacteria,4EIND@85012|Streptosporangiales	201174|Actinobacteria	P	Ferritin-like domain	-	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
TLS2_k127_4972643_21	1122182.KB903813_gene2349	1.486e-54	197.0	COG1595@1|root,COG1595@2|Bacteria,2GKDD@201174|Actinobacteria,4DJ3D@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4972643_27	1121272.KB903250_gene3085	3.729e-17	94.0	COG1595@1|root,COG1595@2|Bacteria,2GKDD@201174|Actinobacteria,4DJ3D@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4972643_31	886377.Murru_3364	9.843e-08	64.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	4.2.2.1	ko:K01727	-	-	-	-	ko00000,ko01000	-	PL8	-	Big_2,DUF285,HYR,Laminin_G_3,Lyase_8,Lyase_8_C,Lyase_8_N,Paired_CXXCH_1,SLH,fn3
TLS2_k127_4972643_24	28444.JODQ01000006_gene64	4.011e-44	167.0	COG1595@1|root,COG1595@2|Bacteria,2IHWH@201174|Actinobacteria,4EJ3W@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_4972643_16	2055.JNXA01000022_gene3809	3.456e-75	262.0	COG0500@1|root,COG2226@2|Bacteria,2GM2N@201174|Actinobacteria,4GFQQ@85026|Gordoniaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_4972643_4	219305.MCAG_03158	7.396e-278	865.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,4D9PJ@85008|Micromonosporales	201174|Actinobacteria	L	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD_C_2
TLS2_k127_5014595_10	1122611.KB903940_gene2029	9.847e-65	240.0	COG0474@1|root,COG0474@2|Bacteria,2I458@201174|Actinobacteria	201174|Actinobacteria	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5014595_5	33876.JNXY01000005_gene8721	2.182e-107	358.0	COG0755@1|root,COG0755@2|Bacteria,2GJR1@201174|Actinobacteria,4D9Z8@85008|Micromonosporales	201174|Actinobacteria	O	cytochrome C	ccsB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
TLS2_k127_5014595_3	1246995.AFR_01340	3.541e-174	571.0	COG1333@1|root,COG1333@2|Bacteria,2GMGH@201174|Actinobacteria,4DAJ8@85008|Micromonosporales	201174|Actinobacteria	O	ResB protein required for cytochrome c biosynthesis	resB	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
TLS2_k127_5014595_8	33876.JNXY01000005_gene8723	3.085e-72	256.0	COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria,4DB7S@85008|Micromonosporales	201174|Actinobacteria	O	cytochrome c biogenesis protein	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
TLS2_k127_5014595_12	1150864.MILUP08_40293	2.487e-42	163.0	COG0526@1|root,COG0526@2|Bacteria,2GP7J@201174|Actinobacteria,4DDRN@85008|Micromonosporales	201174|Actinobacteria	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_5014595_7	35754.JNYJ01000013_gene1027	1.469e-92	309.0	COG0406@1|root,COG0406@2|Bacteria,2GMXF@201174|Actinobacteria,4D9CK@85008|Micromonosporales	201174|Actinobacteria	G	phosphoglycerate mutase	-	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	His_Phos_1
TLS2_k127_5014595_2	644283.Micau_0335	9.661e-207	650.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4DBS3@85008|Micromonosporales	201174|Actinobacteria	H	Aminotransferase	hemL	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_5014595_11	263358.VAB18032_05870	5.535e-46	171.0	COG1366@1|root,COG1366@2|Bacteria,2GSFM@201174|Actinobacteria,4DFCB@85008|Micromonosporales	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
TLS2_k127_5014595_9	644283.Micau_0330	6.633e-70	245.0	COG3437@1|root,COG3437@2|Bacteria,2GNPX@201174|Actinobacteria,4DBVT@85008|Micromonosporales	201174|Actinobacteria	T	Response regulator receiver	osaB	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_5014595_0	1150864.MILUP08_40285	0.0	1945.0	COG0745@1|root,COG1511@1|root,COG4251@1|root,COG0745@2|Bacteria,COG1511@2|Bacteria,COG4251@2|Bacteria,2GKQX@201174|Actinobacteria,4D9S8@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Response_reg
TLS2_k127_5014595_1	1464048.JNZS01000013_gene3123	5.61e-264	832.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2GKN8@201174|Actinobacteria,4DAEE@85008|Micromonosporales	201174|Actinobacteria	T	Stage II sporulation	prpK	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c_2,PAS,PAS_4,SpoIIE
TLS2_k127_5014595_16	477641.MODMU_3732	9.458e-18	93.0	2BECF@1|root,3283J@2|Bacteria,2HDV9@201174|Actinobacteria	201174|Actinobacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5014595_6	1463821.JOGR01000001_gene1237	8.318e-100	341.0	COG0739@1|root,COG0739@2|Bacteria,2GKXN@201174|Actinobacteria,4EXKK@85014|Glycomycetales	201174|Actinobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_5014595_18	644283.Micau_5878	1.768e-07	60.0	2ES16@1|root,33JK8@2|Bacteria,2GPVM@201174|Actinobacteria,4DFXE@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5014595_17	44060.JODL01000032_gene4109	1.261e-17	97.0	2DIGT@1|root,32UB3@2|Bacteria,2I8K4@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5014595_4	1137268.AZXF01000033_gene3404	2.815e-146	495.0	COG3451@1|root,COG3451@2|Bacteria,2I2RD@201174|Actinobacteria,4EGD7@85012|Streptosporangiales	201174|Actinobacteria	U	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_10
TLS2_k127_5014595_14	1137268.AZXF01000033_gene3405	6.977e-20	97.0	2BG1M@1|root,329XU@2|Bacteria,2IHPI@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5014595_15	235985.BBPN01000016_gene5743	1.918e-18	97.0	2E4TH@1|root,32ZMV@2|Bacteria,2HQNS@201174|Actinobacteria	201174|Actinobacteria	S	Conjugative transposon protein TcpC	-	-	-	-	-	-	-	-	-	-	-	-	TpcC
TLS2_k127_5014595_13	1121272.KB903292_gene3780	4.013e-33	135.0	2DVVA@1|root,32V07@2|Bacteria,2IHH0@201174|Actinobacteria,4DEEC@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5035358_0	272560.BPSS1633	0.0	1951.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,1JZUU@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	amino acid adenylation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,PP-binding,Thioesterase
TLS2_k127_5041693_8	477641.MODMU_1362	4.313e-118	390.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4EVS8@85013|Frankiales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS2_k127_5041693_11	1146883.BLASA_2354	1.882e-31	126.0	COG1848@1|root,COG1848@2|Bacteria,2GPX7@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_5041693_0	263358.VAB18032_11185	0.0	1066.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4DA1K@85008|Micromonosporales	201174|Actinobacteria	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS2_k127_5041693_1	644283.Micau_1301	0.0	1024.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4DA6V@85008|Micromonosporales	201174|Actinobacteria	E	Acetolactate synthase	ilvB	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030312,GO:0030976,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3003c	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_5041693_9	33876.JNXY01000027_gene3716	1.69e-81	273.0	COG0440@1|root,COG0440@2|Bacteria,2GJCH@201174|Actinobacteria,4D8VD@85008|Micromonosporales	201174|Actinobacteria	E	Acetolactate synthase small	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
TLS2_k127_5041693_5	644283.Micau_1304	2.145e-177	568.0	COG0059@1|root,COG0059@2|Bacteria,2GKXA@201174|Actinobacteria,4DASF@85008|Micromonosporales	201174|Actinobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008677,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
TLS2_k127_5041693_7	1120949.KB903356_gene8746	3.956e-161	517.0	COG1215@1|root,COG1215@2|Bacteria,2GNFN@201174|Actinobacteria,4D9W8@85008|Micromonosporales	201174|Actinobacteria	M	Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth)	-	-	2.4.1.217	ko:K05947	ko00051,map00051	-	R05768	RC00005,RC00397,RC02748	ko00000,ko00001,ko01000,ko01003	-	-	-	Osmo_MPGsynth
TLS2_k127_5041693_2	1464048.JNZS01000028_gene1733	1.195e-262	817.0	COG1052@1|root,COG1052@2|Bacteria,2I2RK@201174|Actinobacteria,4DAB1@85008|Micromonosporales	201174|Actinobacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
TLS2_k127_5041693_12	1120950.KB892741_gene2680	1.441e-25	108.0	2E935@1|root,333C3@2|Bacteria,2IQ95@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF397
TLS2_k127_5041693_6	1464048.JNZS01000028_gene1736	1.36e-173	550.0	COG0473@1|root,COG0473@2|Bacteria,2GK44@201174|Actinobacteria,4DBEM@85008|Micromonosporales	201174|Actinobacteria	CE	Isocitrate isopropylmalate dehydrogenase	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_5041693_4	1464048.JNZS01000028_gene1737	4.207e-189	595.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4D9QR@85008|Micromonosporales	201174|Actinobacteria	E	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS2_k127_5041693_10	369723.Strop_1241	2.274e-73	255.0	COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria,4DCR5@85008|Micromonosporales	201174|Actinobacteria	T	Tyrosine phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Y_phosphatase3
TLS2_k127_5041693_13	512565.AMIS_65650	2.097e-20	96.0	COG3861@1|root,COG3861@2|Bacteria,2IQ4Y@201174|Actinobacteria,4DF3X@85008|Micromonosporales	201174|Actinobacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5041693_3	356851.JOAN01000003_gene1593	1.512e-256	801.0	COG0119@1|root,COG0119@2|Bacteria,2GKYT@201174|Actinobacteria,4D9E8@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA2	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS2_k127_508243_9	1120950.KB892778_gene1017	5.315e-114	368.0	COG2207@1|root,COG2207@2|Bacteria,2GM8I@201174|Actinobacteria,4DT6X@85009|Propionibacteriales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS2_k127_508243_10	1206725.BAFU01000017_gene3365	1.722e-112	374.0	COG0262@1|root,COG0262@2|Bacteria,2GK32@201174|Actinobacteria,4FX6U@85025|Nocardiaceae	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_508243_25	1229780.BN381_460001	1.572e-10	73.0	COG4974@1|root,COG4974@2|Bacteria,2I9JH@201174|Actinobacteria,3UX4I@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_508243_27	1133849.O3I_036770	9.58e-08	58.0	COG0582@1|root,COG0582@2|Bacteria,2I5V1@201174|Actinobacteria	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_508243_21	1121946.AUAX01000026_gene6254	9.963e-34	148.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,CBM_2
TLS2_k127_508243_16	263358.VAB18032_09810	7.067e-77	260.0	COG0691@1|root,COG0691@2|Bacteria,2GJX1@201174|Actinobacteria,4DCNK@85008|Micromonosporales	201174|Actinobacteria	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
TLS2_k127_508243_11	219305.MCAG_03992	1.585e-98	331.0	COG2177@1|root,COG2177@2|Bacteria,2GJMA@201174|Actinobacteria,4D9UH@85008|Micromonosporales	201174|Actinobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
TLS2_k127_508243_7	369723.Strop_0982	1.728e-129	416.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,4DAY4@85008|Micromonosporales	201174|Actinobacteria	D	cell division ATP-binding protein FtsE	ftsE	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
TLS2_k127_508243_3	1121946.AUAX01000026_gene6260	2.654e-189	599.0	COG1186@1|root,COG1186@2|Bacteria,2GJ0F@201174|Actinobacteria,4D8X4@85008|Micromonosporales	201174|Actinobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS2_k127_508243_18	35754.JNYJ01000087_gene2257	2.008e-73	255.0	COG1695@1|root,COG1695@2|Bacteria,2IFM7@201174|Actinobacteria,4DCRU@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
TLS2_k127_508243_8	1122182.KB903813_gene2710	5.534e-124	404.0	COG3483@1|root,COG3483@2|Bacteria,2GNB1@201174|Actinobacteria,4D8E9@85008|Micromonosporales	201174|Actinobacteria	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
TLS2_k127_508243_6	1133850.SHJG_3935	4.678e-143	483.0	COG2378@1|root,COG2378@2|Bacteria,2I8XQ@201174|Actinobacteria	201174|Actinobacteria	K	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
TLS2_k127_508243_22	28444.JODQ01000006_gene502	4.12e-33	142.0	COG0501@1|root,COG0501@2|Bacteria,2IE08@201174|Actinobacteria	201174|Actinobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS2_k127_508243_15	1122182.KB903825_gene449	2.506e-87	306.0	COG0501@1|root,COG0501@2|Bacteria,2IE08@201174|Actinobacteria,4DD6N@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS2_k127_508243_0	644283.Micau_5381	8.674e-236	732.0	COG0538@1|root,COG0538@2|Bacteria,2GM3D@201174|Actinobacteria,4D97E@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the isocitrate and isopropylmalate dehydrogenases family	icd	GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_508243_28	58123.JOFJ01000025_gene3393	3.005e-06	54.0	COG1317@1|root,COG1317@2|Bacteria,2H94N@201174|Actinobacteria,4EJ09@85012|Streptosporangiales	201174|Actinobacteria	NU	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_508243_26	1121272.KB903249_gene2377	2.732e-08	60.0	COG1317@1|root,COG1317@2|Bacteria,2H94N@201174|Actinobacteria,4DCZ2@85008|Micromonosporales	201174|Actinobacteria	NU	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_508243_12	356851.JOAN01000013_gene5858	9.048e-96	323.0	COG0692@1|root,COG0692@2|Bacteria,2GJ9Z@201174|Actinobacteria,4D8UH@85008|Micromonosporales	201174|Actinobacteria	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	ung	GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_508243_20	1352941.M877_29380	2.257e-34	135.0	COG1324@1|root,COG1324@2|Bacteria,2IQF1@201174|Actinobacteria	201174|Actinobacteria	P	Divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
TLS2_k127_508243_4	1246995.AFR_05125	1.031e-162	518.0	COG0039@1|root,COG0039@2|Bacteria,2GN5S@201174|Actinobacteria,4DC08@85008|Micromonosporales	201174|Actinobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
TLS2_k127_508243_1	1464048.JNZS01000037_gene4687	6.204e-231	726.0	COG0138@1|root,COG0138@2|Bacteria,2GJWU@201174|Actinobacteria,4DADV@85008|Micromonosporales	201174|Actinobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
TLS2_k127_508243_13	479435.Kfla_1276	9.877e-95	313.0	COG0299@1|root,COG0299@2|Bacteria,2H8QB@201174|Actinobacteria,4DPAW@85009|Propionibacteriales	201174|Actinobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
TLS2_k127_508243_23	1246995.AFR_05105	3.989e-20	93.0	2B1SB@1|root,31U83@2|Bacteria,2GTME@201174|Actinobacteria,4DG4X@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_508243_14	644283.Micau_5395	2.593e-89	312.0	COG2311@1|root,COG2311@2|Bacteria,2GKA8@201174|Actinobacteria,4DA0N@85008|Micromonosporales	201174|Actinobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_508243_17	1122182.KB903825_gene392	1.049e-76	262.0	COG2085@1|root,COG2085@2|Bacteria,2GMN3@201174|Actinobacteria,4DDWA@85008|Micromonosporales	201174|Actinobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
TLS2_k127_508243_5	356851.JOAN01000032_gene2787	5.857e-156	495.0	COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria,4D8W3@85008|Micromonosporales	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
TLS2_k127_508243_2	219305.MCAG_01961	2.764e-197	620.0	COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria,4DAKW@85008|Micromonosporales	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
TLS2_k127_508243_19	644283.Micau_5399	8.681e-68	236.0	COG2185@1|root,COG2185@2|Bacteria,2IFJD@201174|Actinobacteria,4DDD4@85008|Micromonosporales	201174|Actinobacteria	I	B12 binding domain	icmB	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
TLS2_k127_5234868_19	134676.ACPL_720	1.797e-70	248.0	2DMAW@1|root,32EM1@2|Bacteria,2I9A0@201174|Actinobacteria,4D8YH@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5234868_15	1464048.JNZS01000005_gene5487	7.323e-115	384.0	COG2267@1|root,COG2267@2|Bacteria,2GM96@201174|Actinobacteria,4DBN6@85008|Micromonosporales	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS2_k127_5234868_20	1121946.AUAX01000003_gene1617	4.233e-64	232.0	COG5479@1|root,COG5479@2|Bacteria,2GMJR@201174|Actinobacteria,4DCV5@85008|Micromonosporales	201174|Actinobacteria	M	Protein of unknown function (DUF3152)	peg3	-	-	-	-	-	-	-	-	-	-	-	DUF3152
TLS2_k127_5234868_2	263358.VAB18032_01410	2.798e-224	699.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2GJB6@201174|Actinobacteria,4D8E5@85008|Micromonosporales	201174|Actinobacteria	HP	Molybdopterin biosynthesis-like protein MoeZ	moeB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0061605,GO:0070566,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
TLS2_k127_5234868_8	1298880.AUEV01000001_gene5838	4.618e-137	446.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS2_k127_5234868_0	1246995.AFR_02080	2.8e-322	990.0	COG1061@1|root,COG1061@2|Bacteria,2GIR9@201174|Actinobacteria,4D9I6@85008|Micromonosporales	201174|Actinobacteria	L	ERCC3/RAD25/XPB C-terminal helicase	ercc3	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
TLS2_k127_5234868_1	1136417.AZWE01000012_gene2420	1.816e-265	839.0	COG2378@1|root,COG2378@2|Bacteria,2GURQ@201174|Actinobacteria,4D9PF@85008|Micromonosporales	201174|Actinobacteria	K	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
TLS2_k127_5234868_23	263358.VAB18032_06565	1.242e-58	218.0	COG1278@1|root,COG1278@2|Bacteria,2IKXN@201174|Actinobacteria,4DEIA@85008|Micromonosporales	201174|Actinobacteria	K	Cold shock	cspB	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_5234868_29	512565.AMIS_72090	2.737e-08	67.0	COG1520@1|root,COG1520@2|Bacteria,2GXG5@201174|Actinobacteria,4DKX2@85008|Micromonosporales	201174|Actinobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_5234868_13	369723.Strop_3946	8.562e-124	402.0	COG2107@1|root,COG2107@2|Bacteria,2GJHY@201174|Actinobacteria,4DA8H@85008|Micromonosporales	201174|Actinobacteria	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
TLS2_k127_5234868_27	1246995.AFR_37415	1.52e-16	94.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
TLS2_k127_5234868_21	1246995.AFR_02110	8.381e-61	216.0	COG0775@1|root,COG0775@2|Bacteria,2GNXM@201174|Actinobacteria,4DB0Q@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnB	-	3.2.2.26	ko:K11783	ko00130,ko01110,map00130,map01110	-	R08587	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_5234868_5	1136417.AZWE01000016_gene96	5.023e-167	539.0	COG2211@1|root,COG2211@2|Bacteria,2I33Q@201174|Actinobacteria,4DA77@85008|Micromonosporales	201174|Actinobacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_5234868_12	512565.AMIS_3800	3.827e-125	406.0	28NWB@1|root,2ZBU7@2|Bacteria,2GJ74@201174|Actinobacteria,4DAVM@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3027)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3027
TLS2_k127_5234868_28	1246995.AFR_02125	1.371e-09	63.0	2CGTN@1|root,33IM2@2|Bacteria,2IRHP@201174|Actinobacteria,4DFGV@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF2530)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2530
TLS2_k127_5234868_22	391037.Sare_0505	1.333e-59	209.0	COG1846@1|root,COG1846@2|Bacteria,2IFQ9@201174|Actinobacteria,4DDS4@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_5234868_6	644283.Micau_0509	5.926e-163	523.0	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria,4D9ES@85008|Micromonosporales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_5234868_24	1150864.MILUP08_40511	4.437e-43	164.0	COG1514@1|root,COG1514@2|Bacteria,2GNDN@201174|Actinobacteria,4DEDE@85008|Micromonosporales	201174|Actinobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
TLS2_k127_5234868_32	287986.DV20_41140	5.253e-08	65.0	COG0494@1|root,COG0494@2|Bacteria,2HNEM@201174|Actinobacteria,4E09R@85010|Pseudonocardiales	201174|Actinobacteria	L	nUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5234868_3	644283.Micau_0512	1.961e-180	574.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4D9X8@85008|Micromonosporales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	ko:K13315	ko00523,ko01130,map00523,map01130	M00798,M00799	R11051,R11474	RC00897,RC01516	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldo_ket_red
TLS2_k127_5234868_9	543632.JOJL01000028_gene104	3.017e-134	437.0	28PUQ@1|root,2ZCFK@2|Bacteria,2GNQM@201174|Actinobacteria,4DAMW@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3071)	-	GO:0008150,GO:0040007	-	-	-	-	-	-	-	-	-	-	DUF3071
TLS2_k127_5234868_30	928724.SacglDRAFT_00151	3.34e-08	66.0	COG1595@1|root,COG1595@2|Bacteria,2GP81@201174|Actinobacteria,4E31R@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_5234868_4	219305.MCAG_03291	4.503e-171	546.0	COG1932@1|root,COG1932@2|Bacteria,2GKYK@201174|Actinobacteria,4D8WE@85008|Micromonosporales	201174|Actinobacteria	EH	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TLS2_k127_5234868_18	1120949.KB903320_gene2902	2.668e-75	258.0	COG0259@1|root,COG0259@2|Bacteria,2GJCR@201174|Actinobacteria,4DBQK@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0010181,GO:0016491,GO:0016614,GO:0016899,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032553,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042803,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2607	PNP_phzG_C,Putative_PNPOx
TLS2_k127_5234868_11	356851.JOAN01000001_gene3464	2.761e-125	407.0	COG2017@1|root,COG2017@2|Bacteria,2GJ0H@201174|Actinobacteria,4D9GB@85008|Micromonosporales	201174|Actinobacteria	G	Aldose 1-epimerase	yihR	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
TLS2_k127_5234868_25	1464048.JNZS01000005_gene5423	8.467e-27	110.0	COG3311@1|root,COG3311@2|Bacteria,2GQGV@201174|Actinobacteria,4DFPC@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix domain	xis	-	-	-	-	-	-	-	-	-	-	-	HTH_17
TLS2_k127_5234868_7	219305.MCAG_02216	8.122e-140	455.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria,4D908@85008|Micromonosporales	201174|Actinobacteria	GM	Nad-dependent epimerase dehydratase	galE2	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0501	Epimerase
TLS2_k127_5234868_10	1121946.AUAX01000003_gene1561	1.152e-131	429.0	COG0204@1|root,COG0204@2|Bacteria,2GJKH@201174|Actinobacteria,4DBV2@85008|Micromonosporales	201174|Actinobacteria	I	Phosphate acyltransferases	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TLS2_k127_5234868_14	369723.Strop_0348	5.738e-115	378.0	COG0560@1|root,COG0560@2|Bacteria,2GJW9@201174|Actinobacteria,4D9PD@85008|Micromonosporales	201174|Actinobacteria	E	HAD-superfamily subfamily IB hydrolase, TIGR01490	serB1	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HAD
TLS2_k127_5234868_17	644283.Micau_5650	4.239e-76	268.0	COG3170@1|root,COG3170@2|Bacteria,2GJWK@201174|Actinobacteria,4DC1I@85008|Micromonosporales	201174|Actinobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5234868_16	1120949.KB903306_gene7442	2.105e-113	374.0	COG1595@1|root,COG1595@2|Bacteria,2GJER@201174|Actinobacteria,4DB56@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	adsA	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_5234868_26	1136417.AZWE01000015_gene1521	1.263e-23	104.0	COG0695@1|root,COG0695@2|Bacteria,2IR0P@201174|Actinobacteria,4DFSF@85008|Micromonosporales	201174|Actinobacteria	O	Glutaredoxin-like domain (DUF836)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF836
TLS2_k127_5243935_26	253839.SSNG_00092	2.269e-24	106.0	2E5JX@1|root,330B5@2|Bacteria,2GRDA@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4235
TLS2_k127_5243935_23	1150864.MILUP08_42375	1.501e-35	147.0	2DMMR@1|root,32SHV@2|Bacteria,2IQA6@201174|Actinobacteria,4DEC5@85008|Micromonosporales	201174|Actinobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
TLS2_k127_5243935_11	644283.Micau_2214	3.778e-97	326.0	COG1295@1|root,COG1295@2|Bacteria,2GM6P@201174|Actinobacteria,4DCGY@85008|Micromonosporales	201174|Actinobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_5243935_14	1136417.AZWE01000003_gene3420	5.149e-88	292.0	COG0537@1|root,COG0537@2|Bacteria,2GJT5@201174|Actinobacteria,4DAGB@85008|Micromonosporales	201174|Actinobacteria	FG	Histidine triad (HIT) protein	-	GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
TLS2_k127_5243935_1	391037.Sare_5060	7.271e-214	693.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4D91T@85008|Micromonosporales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
TLS2_k127_5243935_8	1150864.MILUP08_46660	9.141e-121	425.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4D9K4@85008|Micromonosporales	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,HTH_31,NB-ARC,TPR_10,TPR_12,Trans_reg_C
TLS2_k127_5243935_13	1380347.JNII01000009_gene2007	1.213e-88	304.0	COG1609@1|root,COG1609@2|Bacteria,2GNVD@201174|Actinobacteria,4EUMA@85013|Frankiales	201174|Actinobacteria	K	periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_5243935_17	1341646.CBMO010000052_gene3563	1.366e-61	230.0	COG0044@1|root,COG0044@2|Bacteria,2IARA@201174|Actinobacteria,23490@1762|Mycobacteriaceae	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS2_k127_5243935_22	1532557.JL37_17400	5.009e-38	152.0	COG1028@1|root,COG1028@2|Bacteria,1MV44@1224|Proteobacteria,2VJH7@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	short-chain dehydrogenase reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_5243935_29	649831.L083_3437	3.192e-05	55.0	COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,2GJI2@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase	adhE	-	1.1.1.1,1.2.1.10,1.2.1.81	ko:K04072,ko:K15515	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh,Fe-ADH
TLS2_k127_5243935_16	1122919.KB905548_gene2369	3.094e-68	250.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,4HAT7@91061|Bacilli,26QP9@186822|Paenibacillaceae	91061|Bacilli	E	Xaa-Pro dipeptidase	yqhT	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
TLS2_k127_5243935_21	1532557.JL37_17400	2.446e-46	177.0	COG1028@1|root,COG1028@2|Bacteria,1MV44@1224|Proteobacteria,2VJH7@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	short-chain dehydrogenase reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_5243935_18	1123023.JIAI01000001_gene7406	1.221e-60	223.0	COG1176@1|root,COG1177@1|root,COG1176@2|Bacteria,COG1177@2|Bacteria,2I33W@201174|Actinobacteria,4EEAJ@85010|Pseudonocardiales	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	phnV	-	-	ko:K11082	ko02010,map02010	M00302	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.5	-	-	BPD_transp_1
TLS2_k127_5243935_19	1123023.JIAI01000001_gene7406	5.5e-60	218.0	COG1176@1|root,COG1177@1|root,COG1176@2|Bacteria,COG1177@2|Bacteria,2I33W@201174|Actinobacteria,4EEAJ@85010|Pseudonocardiales	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	phnV	-	-	ko:K11082	ko02010,map02010	M00302	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.5	-	-	BPD_transp_1
TLS2_k127_5243935_10	1123023.JIAI01000001_gene7405	6.008e-108	366.0	COG0687@1|root,COG0687@2|Bacteria,2HRZE@201174|Actinobacteria,4EBHF@85010|Pseudonocardiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_6,SBP_bac_8
TLS2_k127_5243935_12	1123023.JIAI01000001_gene7404	5.411e-97	329.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4E01K@85010|Pseudonocardiales	201174|Actinobacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
TLS2_k127_5243935_6	68570.DC74_226	1.181e-123	408.0	COG0075@1|root,COG0075@2|Bacteria,2GM5F@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TLS2_k127_5243935_0	356851.JOAN01000011_gene5330	0.0	1092.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4D8DQ@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
TLS2_k127_5243935_3	644283.Micau_2778	4.752e-169	542.0	COG1626@1|root,COG1626@2|Bacteria,2I1MU@201174|Actinobacteria,4DCE4@85008|Micromonosporales	201174|Actinobacteria	G	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63,Trehalase
TLS2_k127_5243935_28	1172180.KB911789_gene2783	6.143e-10	66.0	2EFEE@1|root,33978@2|Bacteria,2IFP8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5243935_7	35754.JNYJ01000037_gene4685	1.896e-121	393.0	COG0745@1|root,COG0745@2|Bacteria,2GMVN@201174|Actinobacteria,4D939@85008|Micromonosporales	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_5243935_5	35754.JNYJ01000037_gene4686	3.286e-128	432.0	COG0642@1|root,COG0642@2|Bacteria,2GMHQ@201174|Actinobacteria,4D9KV@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_5243935_25	1246995.AFR_31215	9.113e-31	122.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria,4DEWR@85008|Micromonosporales	201174|Actinobacteria	K	Cold shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_5243935_4	469371.Tbis_1500	1.868e-163	532.0	COG0477@1|root,COG2814@2|Bacteria,2I2DZ@201174|Actinobacteria,4DYAW@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_5243935_24	35754.JNYJ01000054_gene9727	7.857e-34	138.0	2DQVM@1|root,338Y0@2|Bacteria,2I9JA@201174|Actinobacteria,4DEM0@85008|Micromonosporales	201174|Actinobacteria	S	LppX_LprAFG lipoprotein	lprG	GO:0003674,GO:0005102,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008289,GO:0009405,GO:0009605,GO:0009607,GO:0009966,GO:0010469,GO:0010646,GO:0016020,GO:0020012,GO:0023051,GO:0030312,GO:0030545,GO:0030682,GO:0031982,GO:0035091,GO:0042783,GO:0042785,GO:0043167,GO:0043168,GO:0043207,GO:0043226,GO:0043227,GO:0043230,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044421,GO:0044464,GO:0048018,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051812,GO:0051832,GO:0051834,GO:0051861,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0065009,GO:0071944,GO:0075136,GO:0097367,GO:0097691,GO:0098772,GO:1903561	-	ko:K14954,ko:K14955	ko05152,map05152	-	-	-	ko00000,ko00001	-	-	-	LppX_LprAFG
TLS2_k127_5243935_9	263358.VAB18032_14425	7.978e-114	381.0	COG0668@1|root,COG0668@2|Bacteria,2GJ51@201174|Actinobacteria,4D9AG@85008|Micromonosporales	201174|Actinobacteria	M	Mechanosensitive ion channel	mscS	-	-	-	-	-	-	-	-	-	-	-	MS_channel
TLS2_k127_5243935_20	1476583.DEIPH_ctg032orf0002	1.714e-51	191.0	COG0454@1|root,COG0456@2|Bacteria,1WJ43@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_5243935_2	1120950.KB892751_gene6801	1.466e-180	580.0	COG0477@1|root,COG2814@2|Bacteria,2IDJ6@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_5243935_15	1121272.KB903249_gene1310	3.037e-84	281.0	arCOG03175@1|root,32RFA@2|Bacteria,2IFE3@201174|Actinobacteria,4DCZ8@85008|Micromonosporales	201174|Actinobacteria	D	Streptomyces sporulation and cell division protein, SsgA	ssgB	GO:0000003,GO:0000910,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006725,GO:0006732,GO:0007049,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009653,GO:0009987,GO:0010564,GO:0010927,GO:0016043,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0018130,GO:0018958,GO:0019438,GO:0019748,GO:0019752,GO:0019954,GO:0022402,GO:0022607,GO:0030154,GO:0030312,GO:0030428,GO:0030435,GO:0030436,GO:0030447,GO:0030448,GO:0030638,GO:0030639,GO:0031160,GO:0032465,GO:0032467,GO:0032502,GO:0032506,GO:0032989,GO:0032991,GO:0040007,GO:0042180,GO:0042181,GO:0042221,GO:0042244,GO:0042546,GO:0043436,GO:0043648,GO:0043650,GO:0043934,GO:0043936,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044457,GO:0044464,GO:0044550,GO:0045229,GO:0045787,GO:0046189,GO:0046394,GO:0046483,GO:0048518,GO:0048522,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051188,GO:0051301,GO:0051302,GO:0051716,GO:0051726,GO:0051781,GO:0065007,GO:0070590,GO:0070726,GO:0070887,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0090068,GO:0090529,GO:1901110,GO:1901112,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1902074,GO:1902075,GO:1903664,GO:1903666,GO:1990586,GO:2000241,GO:2000243,GO:2000244,GO:2000246	-	-	-	-	-	-	-	-	-	-	SsgA
TLS2_k127_5243935_27	1463909.KL585978_gene6899	2.013e-22	98.0	2AURS@1|root,31KER@2|Bacteria,2IKNV@201174|Actinobacteria	201174|Actinobacteria	S	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS2_k127_5288399_5	1121946.AUAX01000001_gene2108	5.344e-54	196.0	2D9MJ@1|root,32TTI@2|Bacteria,2IFFM@201174|Actinobacteria,4DEH1@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the cytochrome c oxidase bacterial subunit CtaF family	ctaF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Cyt_c_ox_IV
TLS2_k127_5288399_3	219305.MCAG_01292	2.406e-127	416.0	COG1622@1|root,COG1622@2|Bacteria,2GNXA@201174|Actinobacteria,4D8RY@85008|Micromonosporales	201174|Actinobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	ctaC	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
TLS2_k127_5288399_1	644283.Micau_4573	9.675e-148	496.0	COG1104@1|root,COG1104@2|Bacteria,2GJ2B@201174|Actinobacteria,4DBH8@85008|Micromonosporales	201174|Actinobacteria	E	Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5,TusA
TLS2_k127_5288399_6	33876.JNXY01000037_gene8068	1.158e-23	116.0	COG0425@1|root,COG0425@2|Bacteria,2GSF4@201174|Actinobacteria,4DFTY@85008|Micromonosporales	201174|Actinobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
TLS2_k127_5288399_0	1246995.AFR_09370	1.913e-162	522.0	COG0524@1|root,COG0524@2|Bacteria,2GKBG@201174|Actinobacteria,4DAI0@85008|Micromonosporales	201174|Actinobacteria	G	pfkB family carbohydrate kinase	adoK	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS2_k127_5288399_4	446470.Snas_4146	1.44e-57	203.0	COG0316@1|root,COG0316@2|Bacteria,2IHR0@201174|Actinobacteria,4EYTR@85014|Glycomycetales	201174|Actinobacteria	S	Iron-sulphur cluster biosynthesis	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0071944,GO:1901564	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TLS2_k127_5288399_2	644283.Micau_4578	3.728e-144	467.0	COG1929@1|root,COG1929@2|Bacteria,2GKHX@201174|Actinobacteria,4D8WD@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the glycerate kinase type-1 family	glxK	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
TLS2_k127_547874_6	263358.VAB18032_03250	2.174e-33	136.0	2ASXG@1|root,31ID1@2|Bacteria,2IHVD@201174|Actinobacteria,4DDZE@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_547874_2	1464048.JNZS01000002_gene618	2.212e-105	346.0	COG0813@1|root,COG0813@2|Bacteria,2GNT6@201174|Actinobacteria,4DB9F@85008|Micromonosporales	201174|Actinobacteria	F	phosphorylase	deoD	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03784	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_547874_5	219305.MCAG_02749	3.282e-62	222.0	2F760@1|root,33ZMF@2|Bacteria,2IRR1@201174|Actinobacteria,4DJFE@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_547874_1	263358.VAB18032_03935	9.273e-117	379.0	COG1213@1|root,COG1213@2|Bacteria,2GN1Y@201174|Actinobacteria,4DBFB@85008|Micromonosporales	201174|Actinobacteria	M	transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3,NTP_transferase
TLS2_k127_547874_3	1464048.JNZS01000009_gene5688	1.254e-94	317.0	COG0558@1|root,COG0558@2|Bacteria,2HTW1@201174|Actinobacteria,4D900@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
TLS2_k127_547874_0	369723.Strop_4490	9.726e-178	564.0	COG0438@1|root,COG0438@2|Bacteria,2GM53@201174|Actinobacteria,4D8SV@85008|Micromonosporales	201174|Actinobacteria	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_547874_4	1120949.KB903297_gene5524	6.66e-91	311.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria,4DBAI@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the FPG family	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_5495166_25	219305.MCAG_04514	1.005e-66	241.0	COG0454@1|root,COG0456@2|Bacteria,2IFM6@201174|Actinobacteria,4DD4K@85008|Micromonosporales	201174|Actinobacteria	K	Gcn5-related n-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Condensation
TLS2_k127_5495166_4	1121946.AUAX01000002_gene46	1.695e-198	625.0	COG0346@1|root,COG0346@2|Bacteria,2GVV7@201174|Actinobacteria,4DA2J@85008|Micromonosporales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5495166_6	1464048.JNZS01000008_gene6186	7.516e-180	571.0	COG0498@1|root,COG0498@2|Bacteria,2GNZD@201174|Actinobacteria,4DCA6@85008|Micromonosporales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_5495166_27	1123024.AUII01000005_gene2461	6.982e-45	170.0	COG0716@1|root,COG0716@2|Bacteria,2IQZD@201174|Actinobacteria,4E5JA@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM Flavodoxin	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_1,Flavodoxin_5
TLS2_k127_5495166_13	35754.JNYJ01000012_gene921	4.96e-118	391.0	COG0809@1|root,COG0809@2|Bacteria,2GN51@201174|Actinobacteria,4DATB@85008|Micromonosporales	201174|Actinobacteria	J	Queuosine biosynthesis protein	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
TLS2_k127_5495166_20	1246995.AFR_16780	6.536e-78	268.0	COG1028@1|root,COG1028@2|Bacteria,2HGA2@201174|Actinobacteria,4DCYR@85008|Micromonosporales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_5495166_12	1157637.KB892107_gene3815	7.242e-136	441.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2I312@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02480	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA_3
TLS2_k127_5495166_22	1896.JOAU01000001_gene4187	1.22e-70	247.0	COG2197@1|root,COG2197@2|Bacteria,2GJKM@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	yhcZ	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_5495166_14	479432.Sros_0348	5.036e-114	375.0	COG0190@1|root,COG0190@2|Bacteria,2GJZS@201174|Actinobacteria,4EMH8@85012|Streptosporangiales	201174|Actinobacteria	H	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
TLS2_k127_5495166_24	1237500.ANBA01000002_gene6012	3.844e-68	237.0	COG3404@1|root,COG3404@2|Bacteria,2IIRF@201174|Actinobacteria,4ENQS@85012|Streptosporangiales	201174|Actinobacteria	E	Formiminotransferase-cyclodeaminase	-	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
TLS2_k127_5495166_0	356851.JOAN01000030_gene5008	0.0	1045.0	COG0514@1|root,COG1040@1|root,COG0514@2|Bacteria,COG1040@2|Bacteria,2GJSS@201174|Actinobacteria,4DCC1@85008|Micromonosporales	201174|Actinobacteria	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
TLS2_k127_5495166_19	331869.BAL199_27206	3.901e-93	319.0	COG0412@1|root,COG0412@2|Bacteria,1R9JT@1224|Proteobacteria,2U4J1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS2_k127_5495166_31	58344.JOEL01000003_gene1433	1.31e-11	75.0	2E8T5@1|root,3333Y@2|Bacteria,2IS1D@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5495166_23	1121272.KB903249_gene1637	4.693e-69	246.0	COG5401@1|root,COG5401@2|Bacteria,2IK3M@201174|Actinobacteria,4DDDD@85008|Micromonosporales	201174|Actinobacteria	S	Immunoglobulin-like domain of bacterial spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
TLS2_k127_5495166_11	356851.JOAN01000033_gene1823	9.95e-138	452.0	COG0642@1|root,COG2205@2|Bacteria,2GK1J@201174|Actinobacteria,4DB92@85008|Micromonosporales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07654	ko02020,map02020	M00461	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_5495166_17	263358.VAB18032_20120	5.009e-100	331.0	COG0745@1|root,COG0745@2|Bacteria,2GJRR@201174|Actinobacteria,4DCMD@85008|Micromonosporales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_5495166_28	543632.JOJL01000020_gene528	3.224e-44	168.0	COG3324@1|root,COG3324@2|Bacteria,2IRXF@201174|Actinobacteria,4DEWK@85008|Micromonosporales	201174|Actinobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_5495166_3	443218.AS9A_2989	2.03e-213	676.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,2I8V5@201174|Actinobacteria,234RP@1762|Mycobacteriaceae	201174|Actinobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
TLS2_k127_5495166_10	644283.Micau_5172	1.324e-139	450.0	COG3285@1|root,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria,4DAEK@85008|Micromonosporales	201174|Actinobacteria	L	DNA polymerase LigD, polymerase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
TLS2_k127_5495166_16	1120949.KB903308_gene1215	1.232e-105	347.0	COG1131@1|root,COG1131@2|Bacteria,2I2I7@201174|Actinobacteria,4D9Z7@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_5495166_15	1869.MB27_15690	5.163e-109	366.0	COG0842@1|root,COG0842@2|Bacteria,2GJ7Y@201174|Actinobacteria,4D8MG@85008|Micromonosporales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K01990,ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_5495166_26	67373.JOBF01000027_gene1644	1.702e-66	232.0	COG1309@1|root,COG1309@2|Bacteria,2GP92@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_5495166_29	1869.MB27_01970	8.73e-38	145.0	COG2442@1|root,COG2442@2|Bacteria,2IQVM@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
TLS2_k127_5495166_2	1120950.KB892763_gene5556	1.88e-263	824.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2GMFH@201174|Actinobacteria,4DN4U@85009|Propionibacteriales	201174|Actinobacteria	L	Helix-hairpin-helix domain	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
TLS2_k127_5495166_8	390989.JOEG01000019_gene5928	4.781e-148	498.0	COG0707@1|root,COG0707@2|Bacteria,2GREI@201174|Actinobacteria,4DCGA@85008|Micromonosporales	201174|Actinobacteria	M	Monogalactosyldiacylglycerol (MGDG) synthase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,Glyco_tran_28_C,Glyco_trans_1_4,MGDG_synth,WES_acyltransf
TLS2_k127_5495166_21	1089544.KB912942_gene1266	3.859e-74	258.0	COG0300@1|root,COG0300@2|Bacteria,2I64P@201174|Actinobacteria,4E2W2@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
TLS2_k127_5495166_5	1206101.AZXC01000017_gene3708	1.509e-180	569.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	hpnH	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_12,Fer4_14,Radical_SAM
TLS2_k127_5495166_7	1120950.KB892742_gene2981	5.73e-159	519.0	COG0761@1|root,COG0775@1|root,COG0761@2|Bacteria,COG0775@2|Bacteria,2GIZ7@201174|Actinobacteria,4DP9P@85009|Propionibacteriales	201174|Actinobacteria	IM	LytB protein	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB,PNP_UDP_1
TLS2_k127_5495166_1	351607.Acel_1697	7.127e-284	887.0	COG1657@1|root,COG1657@2|Bacteria,2GM7H@201174|Actinobacteria,4ES7V@85013|Frankiales	201174|Actinobacteria	I	Squalene--hopene cyclase	shc	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
TLS2_k127_5495166_18	1120950.KB892742_gene2983	7.074e-97	328.0	COG0142@1|root,COG0142@2|Bacteria,2GN1P@201174|Actinobacteria,4DQEX@85009|Propionibacteriales	201174|Actinobacteria	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_5495166_9	390989.JOEG01000023_gene5822	7.369e-142	468.0	COG1232@1|root,COG1232@2|Bacteria,2I2Z5@201174|Actinobacteria	201174|Actinobacteria	H	squalene-associated FAD-dependent desaturase	hopC	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS2_k127_5495166_30	1120936.KB907221_gene2149	3.23e-33	131.0	COG1562@1|root,COG1562@2|Bacteria,2GJN2@201174|Actinobacteria,4EIHH@85012|Streptosporangiales	201174|Actinobacteria	I	Squalene/phytoene synthase	crtB	GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
TLS2_k127_5497645_4	33876.JNXY01000009_gene8859	3.506e-147	470.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4D8NT@85008|Micromonosporales	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
TLS2_k127_5497645_16	101510.RHA1_ro02662	6.143e-08	59.0	COG3631@1|root,COG3631@2|Bacteria,2HWPG@201174|Actinobacteria,4G56X@85025|Nocardiaceae	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
TLS2_k127_5497645_9	1068978.AMETH_5299	1.945e-75	270.0	COG2909@1|root,COG2909@2|Bacteria,2I3S2@201174|Actinobacteria,4E97D@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_5497645_13	35754.JNYJ01000022_gene8077	5.401e-58	205.0	COG1595@1|root,COG1595@2|Bacteria,2GWFT@201174|Actinobacteria,4DJEK@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_5497645_15	35754.JNYJ01000047_gene3530	6.731e-26	122.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5497645_0	263358.VAB18032_14630	6.979e-199	640.0	COG0501@1|root,COG0501@2|Bacteria,2ID5B@201174|Actinobacteria,4DABW@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS2_k127_5497645_8	1121946.AUAX01000045_gene7504	3.723e-90	300.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria,4D9GG@85008|Micromonosporales	201174|Actinobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
TLS2_k127_5497645_6	1150864.MILUP08_44994	5.689e-141	454.0	COG0861@1|root,COG0861@2|Bacteria,2GIWU@201174|Actinobacteria,4D8XF@85008|Micromonosporales	201174|Actinobacteria	P	Membrane protein TerC, possibly involved in tellurium resistance	terC	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
TLS2_k127_5497645_12	644283.Micau_4359	1.065e-58	210.0	COG0586@1|root,COG0586@2|Bacteria,2IT22@201174|Actinobacteria,4DM5U@85008|Micromonosporales	201174|Actinobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_5497645_5	35754.JNYJ01000012_gene976	9.633e-142	457.0	COG1660@1|root,COG1660@2|Bacteria,2GMWB@201174|Actinobacteria,4DA8A@85008|Micromonosporales	201174|Actinobacteria	S	Displays ATPase and GTPase activities	yvcJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
TLS2_k127_5497645_7	33876.JNXY01000009_gene8920	3.09e-116	385.0	COG0391@1|root,COG0391@2|Bacteria,2GJBW@201174|Actinobacteria,4DBXZ@85008|Micromonosporales	201174|Actinobacteria	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
TLS2_k127_5497645_1	263358.VAB18032_26025	6.952e-181	569.0	COG1481@1|root,COG1481@2|Bacteria,2GJZU@201174|Actinobacteria,4D8FE@85008|Micromonosporales	201174|Actinobacteria	K	May be required for sporulation	whiA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0043937,GO:0044464,GO:0050789,GO:0050793,GO:0065007,GO:0071944	-	ko:K09762	-	-	-	-	ko00000	-	-	-	HTH_WhiA,LAGLIDADG_WhiA,WhiA_N
TLS2_k127_5497645_2	1121272.KB903252_gene1040	1.872e-180	568.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,4D98B@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TLS2_k127_5497645_3	35754.JNYJ01000012_gene980	2.308e-172	550.0	COG0126@1|root,COG0126@2|Bacteria,2GJC6@201174|Actinobacteria,4DAX7@85008|Micromonosporales	201174|Actinobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
TLS2_k127_5497645_14	35754.JNYJ01000045_gene4030	2.908e-50	183.0	COG0640@1|root,COG0640@2|Bacteria,2GNW2@201174|Actinobacteria,4DG2M@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,HTH_20
TLS2_k127_5497645_11	1120950.KB892796_gene2258	3.056e-71	244.0	COG3832@1|root,COG3832@2|Bacteria,2IMFE@201174|Actinobacteria,4DS84@85009|Propionibacteriales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_5497645_10	1121272.KB903249_gene2417	3.233e-74	259.0	COG3371@1|root,COG3371@2|Bacteria,2II34@201174|Actinobacteria,4DEDX@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
TLS2_k127_5618003_15	1453501.JELR01000002_gene1493	3.242e-06	53.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,464PM@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	COG1404 Subtilisin-like serine proteases	-	GO:0005575,GO:0005576	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PKD,PPC,P_proprotein,Peptidase_S8
TLS2_k127_5618003_0	356851.JOAN01000012_gene5142	0.0	2208.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4D8IH@85008|Micromonosporales	201174|Actinobacteria	L	DEAD H associated domain protein	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
TLS2_k127_5618003_4	1085623.GNIT_3021	1.421e-150	488.0	COG1073@1|root,COG1073@2|Bacteria,1QY08@1224|Proteobacteria,1SJFT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5618003_5	43354.JOIJ01000005_gene2101	4.742e-146	501.0	COG1012@1|root,COG1012@2|Bacteria,2GNM8@201174|Actinobacteria,4DXXJ@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.4	ko:K14519	ko00930,ko01100,ko01120,ko01220,map00930,map01100,map01120,map01220	-	R05099	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS2_k127_5618003_3	644283.Micau_2195	1.761e-170	559.0	COG1741@1|root,COG1741@2|Bacteria,2GIY9@201174|Actinobacteria,4D9FR@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
TLS2_k127_5618003_12	1121946.AUAX01000003_gene1848	1.845e-50	182.0	COG0346@1|root,COG0346@2|Bacteria,2IKKR@201174|Actinobacteria,4DEQP@85008|Micromonosporales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_5618003_6	1869.MB27_36375	4.123e-127	419.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4D9KK@85008|Micromonosporales	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_5618003_9	134676.ACPL_7181	4.965e-98	332.0	COG1912@1|root,COG1912@2|Bacteria,2IASJ@201174|Actinobacteria,4D94Y@85008|Micromonosporales	201174|Actinobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
TLS2_k127_5618003_8	1150864.MILUP08_41598	1.064e-108	359.0	COG0266@1|root,COG0266@2|Bacteria,2GKCW@201174|Actinobacteria,4D93P@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the FPG family	nei	-	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_5618003_11	1150864.MILUP08_41596	1.172e-61	221.0	2EUIK@1|root,33N0M@2|Bacteria,2IB2C@201174|Actinobacteria,4DC5J@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5618003_7	1120949.KB903356_gene8541	9.372e-120	391.0	COG1842@1|root,COG1842@2|Bacteria,2GJGD@201174|Actinobacteria,4D9I7@85008|Micromonosporales	201174|Actinobacteria	KT	Phage shock protein	pspA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044464,GO:0071944	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
TLS2_k127_5618003_14	1121946.AUAX01000034_gene6807	1.178e-34	144.0	COG1396@1|root,COG1396@2|Bacteria,2GR3F@201174|Actinobacteria,4DEB4@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix	clgR	GO:0002682,GO:0002683,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006109,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009268,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009987,GO:0010447,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0010675,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0022611,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031347,GO:0031348,GO:0032268,GO:0032502,GO:0033554,GO:0035821,GO:0040007,GO:0042176,GO:0043207,GO:0043565,GO:0043620,GO:0044003,GO:0044110,GO:0044111,GO:0044114,GO:0044115,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051252,GO:0051254,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060255,GO:0061136,GO:0062012,GO:0065007,GO:0075136,GO:0080090,GO:0080134,GO:0085016,GO:0090062,GO:0097159,GO:1901363,GO:1902680,GO:1902882,GO:1903050,GO:1903362,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_31
TLS2_k127_5618003_13	35754.JNYJ01000005_gene5496	8.533e-46	174.0	COG1546@1|root,COG1546@2|Bacteria,2IQ8T@201174|Actinobacteria,4DEA4@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
TLS2_k127_5618003_10	1121946.AUAX01000034_gene6810	4.94e-80	280.0	COG0558@1|root,COG0558@2|Bacteria,2GK5D@201174|Actinobacteria,4DCW3@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_5618003_1	369723.Strop_1396	9.424e-225	707.0	COG0621@1|root,COG0621@2|Bacteria,2GKRI@201174|Actinobacteria,4DAWC@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
TLS2_k127_5618003_2	479432.Sros_2741	1.714e-205	653.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4EICV@85012|Streptosporangiales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS2_k127_5698574_13	1211815.CBYP010000015_gene2698	5.71e-23	106.0	COG0739@1|root,COG0739@2|Bacteria,2GKXN@201174|Actinobacteria,4EX4C@85013|Frankiales	201174|Actinobacteria	M	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,Peptidase_M23
TLS2_k127_5698574_17	1499968.TCA2_3161	1.376e-05	51.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat,VCBS
TLS2_k127_5698574_15	1048339.KB913029_gene3364	3.803e-18	90.0	COG3209@1|root,COG3209@2|Bacteria,2GK1D@201174|Actinobacteria,4EW27@85013|Frankiales	201174|Actinobacteria	M	TIGRFAM YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB
TLS2_k127_5698574_12	1068980.ARVW01000001_gene6093	2.878e-41	157.0	2ET2C@1|root,33KKI@2|Bacteria,2H90S@201174|Actinobacteria,4ECJR@85010|Pseudonocardiales	201174|Actinobacteria	S	Immunity protein 26	-	-	-	-	-	-	-	-	-	-	-	-	Imm26
TLS2_k127_5698574_9	1150864.MILUP08_42694	2.767e-59	211.0	COG1459@1|root,COG1459@2|Bacteria,2I536@201174|Actinobacteria,4DDYP@85008|Micromonosporales	201174|Actinobacteria	NU	Type II secretion system (T2SS), protein F	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
TLS2_k127_5698574_14	1463920.JOGB01000064_gene4336	1.107e-18	97.0	COG1520@1|root,COG1520@2|Bacteria,2I8RX@201174|Actinobacteria	201174|Actinobacteria	F	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5698574_3	1380390.JIAT01000013_gene125	4.791e-145	496.0	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria,4CQYN@84995|Rubrobacteria	84995|Rubrobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_5698574_11	479432.Sros_0814	5.124e-43	162.0	COG0346@1|root,COG0346@2|Bacteria,2I3V9@201174|Actinobacteria,4EK92@85012|Streptosporangiales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5698574_10	1157637.KB892105_gene1835	2.16e-49	181.0	COG2050@1|root,COG2050@2|Bacteria,2IHSR@201174|Actinobacteria	201174|Actinobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_5698574_4	1121946.AUAX01000020_gene3094	1.809e-111	369.0	COG1131@1|root,COG1131@2|Bacteria,2GJ0Y@201174|Actinobacteria,4DH64@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_5698574_7	1121946.AUAX01000020_gene3095	9.601e-92	307.0	COG0842@1|root,COG0842@2|Bacteria,2GNIQ@201174|Actinobacteria,4D8XH@85008|Micromonosporales	201174|Actinobacteria	V	Abc-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_5698574_0	1121946.AUAX01000020_gene3096	4.571e-234	754.0	28KHJ@1|root,2ZA2Z@2|Bacteria,2I38H@201174|Actinobacteria	201174|Actinobacteria	S	Lantibiotic dehydratase, C terminus	-	-	-	-	-	-	-	-	-	-	-	-	Lant_dehydr_N
TLS2_k127_5698574_5	1121946.AUAX01000020_gene3097	1.137e-104	356.0	28P3A@1|root,2ZBZ1@2|Bacteria,2I38J@201174|Actinobacteria	201174|Actinobacteria	S	Lantibiotic biosynthesis dehydratase C-term	-	-	-	-	-	-	-	-	-	-	-	-	Lant_dehydr_C
TLS2_k127_5698574_6	1463825.JNXC01000017_gene6914	1.722e-100	353.0	2BY20@1|root,32PAD@2|Bacteria,2I8M7@201174|Actinobacteria,4E1UM@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5698574_1	1121946.AUAX01000020_gene3099	1.041e-219	700.0	COG1944@1|root,COG1944@2|Bacteria,2GKBS@201174|Actinobacteria,4DBX7@85008|Micromonosporales	201174|Actinobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
TLS2_k127_5698574_8	1463825.JNXC01000017_gene6916	1e-68	248.0	2ES4A@1|root,30Q4X@2|Bacteria,2HPXV@201174|Actinobacteria,4E8M0@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5698574_2	1121946.AUAX01000020_gene3101	2.011e-163	541.0	COG0778@1|root,COG0778@2|Bacteria,2H6TF@201174|Actinobacteria,4DD7G@85008|Micromonosporales	201174|Actinobacteria	C	Lantibiotic biosynthesis dehydratase C-term	-	-	-	-	-	-	-	-	-	-	-	-	Lant_dehydr_C,Nitroreductase
TLS2_k127_5728889_15	471852.Tcur_2160	2.207e-162	521.0	COG0162@1|root,COG0162@2|Bacteria,2GJPR@201174|Actinobacteria,4EFWJ@85012|Streptosporangiales	201174|Actinobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TLS2_k127_5728889_32	219305.MCAG_04932	2.583e-80	275.0	COG2094@1|root,COG2094@2|Bacteria,2GNW1@201174|Actinobacteria,4DD25@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
TLS2_k127_5728889_5	1136417.AZWE01000003_gene3309	1.514e-221	697.0	COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,4DAIY@85008|Micromonosporales	201174|Actinobacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
TLS2_k127_5728889_6	644283.Micau_2377	1.541e-216	681.0	COG0137@1|root,COG0137@2|Bacteria,2GK96@201174|Actinobacteria,4D9NS@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0071944,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iNJ661.Rv1658	Arginosuc_synth
TLS2_k127_5728889_38	33876.JNXY01000012_gene4150	1.717e-60	228.0	COG1438@1|root,COG1438@2|Bacteria,2GKA5@201174|Actinobacteria,4DDE5@85008|Micromonosporales	201174|Actinobacteria	K	Regulates arginine biosynthesis genes	argR	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
TLS2_k127_5728889_21	219305.MCAG_04926	3.027e-135	456.0	COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria,4DAH1@85008|Micromonosporales	201174|Actinobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_5728889_9	644283.Micau_2374	1.1e-184	591.0	COG4992@1|root,COG4992@2|Bacteria,2GKE9@201174|Actinobacteria,4DBFJ@85008|Micromonosporales	201174|Actinobacteria	E	acetylornithine aminotransferase	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0008150,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_5728889_20	644283.Micau_2373	4.024e-143	464.0	COG0548@1|root,COG0548@2|Bacteria,2GKDS@201174|Actinobacteria,4DC1Z@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
TLS2_k127_5728889_17	263358.VAB18032_15225	7.983e-156	509.0	COG1364@1|root,COG1364@2|Bacteria,2GIW0@201174|Actinobacteria,4DAI1@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
TLS2_k127_5728889_19	219305.MCAG_04922	2.963e-145	471.0	COG0002@1|root,COG0002@2|Bacteria,2GKQK@201174|Actinobacteria,4D94R@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_5728889_36	1121272.KB903289_gene4154	5.294e-63	231.0	2E9QH@1|root,333WV@2|Bacteria,2IC0C@201174|Actinobacteria,4DFVJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5728889_11	391037.Sare_2139	7.826e-177	575.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4DEDW@85008|Micromonosporales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_5728889_4	1394178.AWOO02000023_gene5538	2.668e-225	730.0	COG0362@1|root,COG0362@2|Bacteria,2GJ2J@201174|Actinobacteria,4EGPM@85012|Streptosporangiales	201174|Actinobacteria	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
TLS2_k127_5728889_30	1120950.KB892762_gene5465	1.834e-84	284.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	yjhB	-	3.6.1.13,3.6.1.55	ko:K01515,ko:K03574	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000,ko03400	-	-	-	NUDIX,Nudix_N
TLS2_k127_5728889_34	649831.L083_0302	2.385e-70	243.0	COG0262@1|root,COG0262@2|Bacteria,2IHZ7@201174|Actinobacteria,4DDNF@85008|Micromonosporales	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_5728889_48	1120950.KB892772_gene1119	5.024e-28	114.0	2BB4Q@1|root,324M3@2|Bacteria,2H9HU@201174|Actinobacteria,4DWEJ@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5728889_39	134676.ACPL_2829	1.287e-56	206.0	COG1266@1|root,COG1266@2|Bacteria,2GKRA@201174|Actinobacteria,4DFSG@85008|Micromonosporales	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_5728889_41	1121946.AUAX01000002_gene64	1.644e-47	176.0	2EPBK@1|root,33GYC@2|Bacteria,2IHZ9@201174|Actinobacteria,4DG2Z@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5728889_43	479432.Sros_8619	6.024e-44	175.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,4EFJ9@85012|Streptosporangiales	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4352,Pkinase
TLS2_k127_5728889_10	356851.JOAN01000001_gene3547	2.651e-178	562.0	COG0438@1|root,COG0438@2|Bacteria,2I005@201174|Actinobacteria,4D8E1@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_5728889_14	1464048.JNZS01000004_gene1561	1.977e-162	523.0	COG0438@1|root,COG0438@2|Bacteria,2GNPG@201174|Actinobacteria,4D9TU@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_5728889_16	1150864.MILUP08_40636	1.107e-160	531.0	COG0438@1|root,COG0438@2|Bacteria,2I97T@201174|Actinobacteria,4DC0N@85008|Micromonosporales	201174|Actinobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5728889_3	1464048.JNZS01000004_gene1559	8.024e-240	752.0	COG2152@1|root,COG2152@2|Bacteria,2HNS8@201174|Actinobacteria,4DA52@85008|Micromonosporales	201174|Actinobacteria	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
TLS2_k127_5728889_26	2045.KR76_26825	1.356e-103	344.0	COG2207@1|root,COG2207@2|Bacteria,2GST6@201174|Actinobacteria,4DRT2@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS2_k127_5728889_44	1386089.N865_06290	2.037e-43	166.0	2DMBT@1|root,32HTX@2|Bacteria,2IKXS@201174|Actinobacteria,4FH7X@85021|Intrasporangiaceae	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS2_k127_5728889_28	1206741.BAFX01000075_gene3784	2.761e-87	296.0	COG2318@1|root,COG2318@2|Bacteria,2HUJD@201174|Actinobacteria,4G8PH@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
TLS2_k127_5728889_1	219305.MCAG_04917	0.0	1078.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2GMFD@201174|Actinobacteria,4D9VU@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
TLS2_k127_5728889_8	35754.JNYJ01000001_gene7473	7.031e-186	586.0	COG0016@1|root,COG0016@2|Bacteria,2GJGG@201174|Actinobacteria,4DB5J@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
TLS2_k127_5728889_25	219305.MCAG_04915	2.23e-105	352.0	COG0566@1|root,COG0566@2|Bacteria,2GJI6@201174|Actinobacteria,4DAJB@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	tsnR	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS2_k127_5728889_40	219305.MCAG_04914	3.476e-56	198.0	COG0292@1|root,COG0292@2|Bacteria,2IHTN@201174|Actinobacteria,4DDFK@85008|Micromonosporales	201174|Actinobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
TLS2_k127_5728889_51	512565.AMIS_61850	2.939e-18	88.0	COG0291@1|root,COG0291@2|Bacteria,2GQZW@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
TLS2_k127_5728889_27	391037.Sare_1875	3.162e-95	325.0	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,4DBUR@85008|Micromonosporales	201174|Actinobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
TLS2_k127_5728889_45	263358.VAB18032_15150	9.418e-42	158.0	2E71H@1|root,331K6@2|Bacteria,2IR72@201174|Actinobacteria,4DE0F@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial PH domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016020,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	bPH_6
TLS2_k127_5728889_22	649831.L083_5901	7.02e-127	411.0	COG0040@1|root,COG0040@2|Bacteria,2GNAX@201174|Actinobacteria,4DARG@85008|Micromonosporales	201174|Actinobacteria	E	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
TLS2_k127_5728889_46	1122182.KB903825_gene229	3.124e-37	141.0	COG0140@1|root,COG0140@2|Bacteria,2IQ4D@201174|Actinobacteria,4DF5K@85008|Micromonosporales	201174|Actinobacteria	E	Phosphoribosyl-ATP	hisE	GO:0000287,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0044403,GO:0044419,GO:0044464,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0071944,GO:0075136,GO:0075139	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
TLS2_k127_5728889_37	1150864.MILUP08_42547	4.172e-62	216.0	COG0054@1|root,COG0054@2|Bacteria,2II1Z@201174|Actinobacteria,4DDMU@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
TLS2_k127_5728889_7	103733.JNYO01000026_gene8869	4.867e-204	648.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GIWJ@201174|Actinobacteria,4DXCJ@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	GO:0005575,GO:0005576,GO:0008150,GO:0040007	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1415	DHBP_synthase,GTP_cyclohydro2
TLS2_k127_5728889_33	263358.VAB18032_15100	9.534e-77	264.0	COG0307@1|root,COG0307@2|Bacteria,2GKC5@201174|Actinobacteria,4D8J2@85008|Micromonosporales	201174|Actinobacteria	H	riboflavin synthase, alpha	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
TLS2_k127_5728889_12	1464048.JNZS01000019_gene2326	1.124e-164	526.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2GKAX@201174|Actinobacteria,4D947@85008|Micromonosporales	201174|Actinobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
TLS2_k127_5728889_18	1121946.AUAX01000008_gene7178	5.944e-146	468.0	COG2199@1|root,COG3706@2|Bacteria,2IABQ@201174|Actinobacteria,4D9W3@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
TLS2_k127_5728889_23	263358.VAB18032_15085	7.552e-108	352.0	COG0036@1|root,COG0036@2|Bacteria,2GJZ9@201174|Actinobacteria,4DA76@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TLS2_k127_5728889_2	35754.JNYJ01000001_gene7241	2.209e-244	784.0	COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,2GKEU@201174|Actinobacteria,4DA8M@85008|Micromonosporales	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01990,ko:K21397	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC_tran,FHA,Yop-YscD_cpl
TLS2_k127_5728889_49	1122182.KB903814_gene3123	1.047e-20	105.0	COG3209@1|root,COG3250@1|root,COG3534@1|root,COG3209@2|Bacteria,COG3250@2|Bacteria,COG3534@2|Bacteria,2I35N@201174|Actinobacteria	201174|Actinobacteria	M	sporulation resulting in formation of a cellular spore	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,VCBS
TLS2_k127_5728889_52	106370.Francci3_0959	8.473e-11	64.0	COG2826@1|root,COG2826@2|Bacteria	2|Bacteria	L	transposase and inactivated derivatives, IS30 family	insI1	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
TLS2_k127_5728889_31	1179773.BN6_01930	2.027e-84	287.0	COG2826@1|root,COG2826@2|Bacteria,2GMZX@201174|Actinobacteria,4DZWQ@85010|Pseudonocardiales	201174|Actinobacteria	L	PFAM Integrase, catalytic core	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
TLS2_k127_5728889_29	1136417.AZWE01000057_gene2019	5.961e-87	290.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4D94B@85008|Micromonosporales	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
TLS2_k127_5728889_24	1136417.AZWE01000057_gene2019	1.347e-105	346.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4D94B@85008|Micromonosporales	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
TLS2_k127_5728889_35	1894.JOER01000046_gene4605	1.428e-69	245.0	COG1403@1|root,COG3344@1|root,COG1403@2|Bacteria,COG3344@2|Bacteria,2GUJS@201174|Actinobacteria	201174|Actinobacteria	L	RNA-directed DNA polymerase (reverse transcriptase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,HNH,RVT_1,RVT_N
TLS2_k127_5728889_13	1077144.AGFF01000021_gene900	5.289e-163	523.0	COG3344@1|root,COG3344@2|Bacteria,2GUJS@201174|Actinobacteria	201174|Actinobacteria	L	RNA-directed DNA polymerase (reverse transcriptase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,HNH,RVT_1,RVT_N
TLS2_k127_5728889_47	1127134.NOCYR_0254	4.537e-35	148.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4FUUY@85025|Nocardiaceae	201174|Actinobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
TLS2_k127_5728889_50	994479.GL877878_gene3083	1.824e-18	94.0	COG4467@1|root,COG4467@2|Bacteria,2IDK7@201174|Actinobacteria	201174|Actinobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,zf-IS66
TLS2_k127_5728889_42	1449355.JQNR01000003_gene496	8.858e-46	171.0	2BPZ5@1|root,32IT5@2|Bacteria,2H7Y0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5728889_0	1463821.JOGR01000002_gene473	0.0	1238.0	COG3209@1|root,COG3209@2|Bacteria,2GK1D@201174|Actinobacteria,4EZG0@85014|Glycomycetales	201174|Actinobacteria	M	TIGRFAM YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Hint,PT-HINT,RHS_repeat,SpvB
TLS2_k127_5771015_2	1150399.AQYK01000001_gene162	3.773e-117	382.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria,4FR3Z@85023|Microbacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5771015_1	1246995.AFR_30545	3.014e-204	647.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2GM21@201174|Actinobacteria,4D9W7@85008|Micromonosporales	201174|Actinobacteria	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	fmu	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
TLS2_k127_5771015_3	1463887.KL589977_gene8235	4.722e-107	355.0	COG0223@1|root,COG0223@2|Bacteria,2GKH5@201174|Actinobacteria	201174|Actinobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TLS2_k127_5771015_4	369723.Strop_1868	2.694e-98	323.0	COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,4DAN9@85008|Micromonosporales	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TLS2_k127_5771015_0	1136417.AZWE01000003_gene3339	1.821e-275	863.0	COG1198@1|root,COG1198@2|Bacteria,2GKES@201174|Actinobacteria,4DA4R@85008|Micromonosporales	201174|Actinobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
TLS2_k127_581163_6	644283.Micau_5297	5.241e-173	548.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4D9MD@85008|Micromonosporales	201174|Actinobacteria	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_581163_5	219305.MCAG_01892	2.874e-181	576.0	COG0612@1|root,COG0612@2|Bacteria,2GKAT@201174|Actinobacteria,4DBWR@85008|Micromonosporales	201174|Actinobacteria	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_581163_11	1246995.AFR_38390	3.512e-99	338.0	COG2816@1|root,COG2816@2|Bacteria,2GJZY@201174|Actinobacteria,4D9ZE@85008|Micromonosporales	201174|Actinobacteria	L	Nudix hydrolase	nudC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
TLS2_k127_581163_14	471857.Svir_18080	3.266e-53	195.0	COG0640@1|root,COG0640@2|Bacteria,2IEHG@201174|Actinobacteria,4E40T@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_581163_8	471857.Svir_18070	4.8e-115	381.0	COG1131@1|root,COG1131@2|Bacteria,2GJ84@201174|Actinobacteria,4E5K0@85010|Pseudonocardiales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC_tran
TLS2_k127_581163_13	471857.Svir_18060	5.833e-71	248.0	COG0842@1|root,COG0842@2|Bacteria,2IITR@201174|Actinobacteria,4E80Z@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_581163_16	263358.VAB18032_00160	7.746e-34	132.0	COG0695@1|root,COG0695@2|Bacteria,2IQF9@201174|Actinobacteria,4DEXP@85008|Micromonosporales	201174|Actinobacteria	O	Glutaredoxin	-	-	1.20.4.3	ko:K18917	-	-	-	-	ko00000,ko01000	-	-	-	Glutaredoxin
TLS2_k127_581163_1	644283.Micau_5289	2.575e-311	967.0	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria,4D9QI@85008|Micromonosporales	201174|Actinobacteria	L	DNA helicase	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
TLS2_k127_581163_15	1150864.MILUP08_46065	2.378e-44	164.0	2DMIS@1|root,32RVG@2|Bacteria,2IQ99@201174|Actinobacteria,4DDAV@85008|Micromonosporales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB7	GO:0001101,GO:0008150,GO:0010033,GO:0033993,GO:0042221,GO:0046677,GO:0050896,GO:0070542,GO:1901700	-	ko:K18958	-	-	-	-	ko00000,ko03000	-	-	-	AT_hook,Whib
TLS2_k127_581163_3	219305.MCAG_01882	2.531e-203	644.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4D9DI@85008|Micromonosporales	201174|Actinobacteria	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1,APH
TLS2_k127_581163_10	219305.MCAG_01881	2.413e-102	344.0	COG0476@1|root,COG0476@2|Bacteria,2GMJI@201174|Actinobacteria,4DC8S@85008|Micromonosporales	201174|Actinobacteria	H	UBA ThiF-type NAD FAD binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
TLS2_k127_581163_17	1136417.AZWE01000001_gene3807	1.732e-24	105.0	2E479@1|root,32Z35@2|Bacteria,2GQXY@201174|Actinobacteria,4DFRY@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_581163_12	644283.Micau_5283	5.263e-72	246.0	COG1451@1|root,COG1451@2|Bacteria,2GMP6@201174|Actinobacteria,4D94T@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
TLS2_k127_581163_4	644283.Micau_5281	6.203e-197	620.0	COG5282@1|root,COG5282@2|Bacteria,2GJ9K@201174|Actinobacteria,4D8KY@85008|Micromonosporales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
TLS2_k127_581163_9	391037.Sare_4111	3.962e-112	374.0	COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria,4D9ZI@85008|Micromonosporales	201174|Actinobacteria	T	Belongs to the peptidase S16 family	lon	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
TLS2_k127_581163_0	1150864.MILUP08_46056	0.0	1132.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4D8UZ@85008|Micromonosporales	201174|Actinobacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
TLS2_k127_581163_2	653045.Strvi_3815	8.085e-273	852.0	COG0021@1|root,COG0021@2|Bacteria,2I36F@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the transketolase family	tkt3	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TLS2_k127_581163_7	103733.JNYO01000043_gene5876	5.172e-150	492.0	COG1404@1|root,COG3386@1|root,COG1404@2|Bacteria,COG3386@2|Bacteria,2IEGJ@201174|Actinobacteria,4DXZF@85010|Pseudonocardiales	201174|Actinobacteria	O	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CarboxypepD_reg,Malectin,Peptidase_S8
TLS2_k127_5849538_7	243231.GSU1839	4.24e-23	108.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,42W4B@68525|delta/epsilon subdivisions,2WP0P@28221|Deltaproteobacteria,43UMI@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_5849538_0	263358.VAB18032_00215	0.0	1394.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria,4DC0K@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS2_k127_5849538_1	263358.VAB18032_00220	0.0	1300.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GJD0@201174|Actinobacteria,4DB8B@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD3	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS2_k127_5849538_5	1463936.JOJI01000072_gene7303	7.529e-110	365.0	COG0207@1|root,COG0207@2|Bacteria,2GKY0@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	-	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
TLS2_k127_5849538_8	316274.Haur_0170	4.987e-08	66.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
TLS2_k127_5849538_9	1278311.AUAL01000004_gene372	2.031e-07	60.0	COG1428@1|root,COG1428@2|Bacteria,3WT89@544448|Tenericutes	544448|Tenericutes	F	Deoxynucleoside kinase	dck	-	2.7.1.74,2.7.1.76	ko:K15519	ko00230,ko00240,ko01100,map00230,map00240,map01100	-	R00185,R01666,R02089	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	dNK
TLS2_k127_5849538_2	33876.JNXY01000010_gene2603	2.718e-175	555.0	COG0624@1|root,COG0624@2|Bacteria,2GK09@201174|Actinobacteria,4DAS9@85008|Micromonosporales	201174|Actinobacteria	E	succinyl-diaminopimelate desuccinylase	dapE	GO:0008150,GO:0040007	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_5849538_4	649831.L083_7282	1.746e-140	452.0	COG2171@1|root,COG2171@2|Bacteria,2GIZ9@201174|Actinobacteria,4DAP0@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA	dapD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008666,GO:0016020,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0030312,GO:0031402,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0071944	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1201c	Hexapep_2,THDPS_M
TLS2_k127_5849538_6	1157632.AQWQ01000001_gene6195	1.934e-64	232.0	COG0572@1|root,COG0572@2|Bacteria,2I9H4@201174|Actinobacteria	201174|Actinobacteria	F	Fructose transport system kinase	frcK	-	-	-	-	-	-	-	-	-	-	-	PRK
TLS2_k127_5849538_3	1246995.AFR_38740	7.791e-167	530.0	COG0436@1|root,COG0436@2|Bacteria,2GJMI@201174|Actinobacteria,4DB04@85008|Micromonosporales	201174|Actinobacteria	E	Aminotransferase	dapC	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS2_k127_5879028_13	644283.Micau_4067	4.996e-96	325.0	COG0500@1|root,COG0500@2|Bacteria,2I63A@201174|Actinobacteria,4DH7S@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_25
TLS2_k127_5879028_14	1463934.JOCF01000089_gene2154	7.157e-95	324.0	COG0475@1|root,COG0475@2|Bacteria,2GIRC@201174|Actinobacteria	201174|Actinobacteria	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS2_k127_5879028_20	1236902.ANAS01000013_gene1318	3.774e-75	268.0	COG1503@1|root,COG1503@2|Bacteria,2IJI5@201174|Actinobacteria,4EMMU@85012|Streptosporangiales	201174|Actinobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5879028_28	452652.KSE_01740	2.956e-41	161.0	COG1051@1|root,COG1051@2|Bacteria,2I2YK@201174|Actinobacteria,2M3HA@2063|Kitasatospora	201174|Actinobacteria	F	belongs to the nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_5879028_1	35754.JNYJ01000017_gene6353	3.346e-216	680.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GNDC@201174|Actinobacteria,4DACD@85008|Micromonosporales	201174|Actinobacteria	F	IMP dehydrogenase GMP reductase	guaB1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TLS2_k127_5879028_30	369723.Strop_1755	1.119e-24	109.0	COG1503@1|root,COG1503@2|Bacteria,2GQC6@201174|Actinobacteria,4DF79@85008|Micromonosporales	201174|Actinobacteria	J	Protein of unknown function (DUF2795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2795
TLS2_k127_5879028_10	479433.Caci_7536	5.531e-116	387.0	COG0438@1|root,COG0438@2|Bacteria,2GNPG@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_5879028_8	35754.JNYJ01000013_gene1145	3.487e-123	404.0	COG2152@1|root,COG2152@2|Bacteria,2HNS8@201174|Actinobacteria	201174|Actinobacteria	G	PFAM glycosidase, PH1107-related	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
TLS2_k127_5879028_21	369723.Strop_1901	6.802e-75	266.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4DD1H@85008|Micromonosporales	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_5879028_17	369723.Strop_1579	4.242e-88	301.0	COG0778@1|root,COG0778@2|Bacteria,2I8P3@201174|Actinobacteria,4D8FS@85008|Micromonosporales	201174|Actinobacteria	C	Nitroreductase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_5879028_5	263358.VAB18032_24355	4.213e-135	456.0	COG4907@1|root,COG4907@2|Bacteria,2IBZ3@201174|Actinobacteria,4DBRQ@85008|Micromonosporales	201174|Actinobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
TLS2_k127_5879028_19	479434.Sthe_0108	4.15e-76	267.0	COG2159@1|root,COG2159@2|Bacteria,2G8UX@200795|Chloroflexi,27Z57@189775|Thermomicrobia	189775|Thermomicrobia	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
TLS2_k127_5879028_7	749927.AMED_4776	3.963e-128	448.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4E0IZ@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,NB-ARC,TPR_12,Trans_reg_C
TLS2_k127_5879028_6	58123.JOFJ01000008_gene525	4.902e-135	439.0	COG2227@1|root,COG2227@2|Bacteria,2I3C3@201174|Actinobacteria,4ER5A@85012|Streptosporangiales	201174|Actinobacteria	H	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_5879028_23	1237500.ANBA01000007_gene2922	1.858e-68	241.0	COG0640@1|root,COG0640@2|Bacteria,2GJT9@201174|Actinobacteria,4EI7R@85012|Streptosporangiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_5879028_3	1123065.ATWL01000003_gene659	1.435e-180	577.0	COG2270@1|root,COG2270@2|Bacteria,2I6N9@201174|Actinobacteria	201174|Actinobacteria	S	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_5879028_26	1463895.JODA01000003_gene779	2.186e-49	178.0	COG3801@1|root,COG3801@2|Bacteria,2IHXB@201174|Actinobacteria	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
TLS2_k127_5879028_25	28444.JODQ01000006_gene867	5.345e-52	198.0	COG1252@1|root,COG1252@2|Bacteria,2GKC0@201174|Actinobacteria,4EIQG@85012|Streptosporangiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
TLS2_k127_5879028_29	28444.JODQ01000006_gene867	6.604e-30	121.0	COG1252@1|root,COG1252@2|Bacteria,2GKC0@201174|Actinobacteria,4EIQG@85012|Streptosporangiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
TLS2_k127_5879028_24	28444.JODQ01000006_gene866	5.843e-55	206.0	COG1595@1|root,COG1595@2|Bacteria,2GKBH@201174|Actinobacteria,4EIQV@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
TLS2_k127_5879028_33	28444.JODQ01000006_gene866	7.473e-12	67.0	COG1595@1|root,COG1595@2|Bacteria,2GKBH@201174|Actinobacteria,4EIQV@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
TLS2_k127_5879028_22	1122182.KB903814_gene3341	1.076e-72	262.0	COG0515@1|root,COG0515@2|Bacteria,2GMW3@201174|Actinobacteria,4DF77@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5879028_11	1121946.AUAX01000003_gene1584	1.219e-115	398.0	COG0515@1|root,COG0515@2|Bacteria,2GKFY@201174|Actinobacteria,4DB1T@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	pkn5	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_5879028_0	1121946.AUAX01000003_gene1583	5.301e-226	713.0	COG1716@1|root,COG1994@1|root,COG1716@2|Bacteria,COG1994@2|Bacteria,2IBWH@201174|Actinobacteria,4DB7M@85008|Micromonosporales	201174|Actinobacteria	T	ATPase activity	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	AhpC-TSA,FHA,Yop-YscD_cpl,cNMP_binding
TLS2_k127_5879028_32	1121272.KB903250_gene3138	2.503e-15	89.0	2A798@1|root,30W5U@2|Bacteria,2HADY@201174|Actinobacteria,4DKU9@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5879028_15	1122182.KB903814_gene3376	4.789e-91	342.0	COG2197@1|root,COG3899@1|root,COG2197@2|Bacteria,COG3899@2|Bacteria,2IM7R@201174|Actinobacteria,4DEDP@85008|Micromonosporales	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_5879028_2	479435.Kfla_2107	2.131e-196	675.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2IAS1@201174|Actinobacteria,4DWMF@85009|Propionibacteriales	201174|Actinobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_12,Trans_reg_C
TLS2_k127_5879028_9	794903.OPIT5_24040	5.089e-121	399.0	COG0667@1|root,COG0667@2|Bacteria,46SC2@74201|Verrucomicrobia,3K7X7@414999|Opitutae	414999|Opitutae	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_5879028_18	1121946.AUAX01000007_gene2969	1.275e-82	285.0	COG2334@1|root,COG2334@2|Bacteria,2GQU8@201174|Actinobacteria,4DGMQ@85008|Micromonosporales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_5879028_27	1266925.JHVX01000011_gene1512	3.31e-44	167.0	COG1487@1|root,COG1487@2|Bacteria,1RIB5@1224|Proteobacteria,2VR6N@28216|Betaproteobacteria,373PT@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
TLS2_k127_5879028_12	35754.JNYJ01000017_gene6280	1.767e-112	368.0	COG0566@1|root,COG0566@2|Bacteria,2GP9S@201174|Actinobacteria,4DIFT@85008|Micromonosporales	201174|Actinobacteria	J	SpoU rRNA Methylase family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
TLS2_k127_5879028_4	1120949.KB903297_gene5433	8.785e-160	513.0	COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria,4DB1Y@85008|Micromonosporales	201174|Actinobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	ko:K00479	-	-	-	-	ko00000	-	-	-	Rieske,Ring_hydroxyl_A
TLS2_k127_5879028_16	1122182.KB903838_gene4022	5.69e-90	304.0	COG0030@1|root,COG0030@2|Bacteria,2GIZ8@201174|Actinobacteria,4DBCD@85008|Micromonosporales	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_5879028_31	1155714.KB891988_gene2206	4.397e-18	86.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_5882898_6	322710.Avin_34670	3.572e-07	56.0	COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,1RP39@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major facilitator superfamily	ycaD	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_5882898_1	1121946.AUAX01000001_gene2341	4.191e-122	398.0	COG1562@1|root,COG1562@2|Bacteria,2GJN2@201174|Actinobacteria,4DA9G@85008|Micromonosporales	201174|Actinobacteria	I	Phytoene synthase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
TLS2_k127_5882898_0	1121946.AUAX01000001_gene2340	9.698e-232	725.0	COG1233@1|root,COG1233@2|Bacteria,2GJAV@201174|Actinobacteria,4D943@85008|Micromonosporales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
TLS2_k127_5882898_3	33876.JNXY01000025_gene5413	9.875e-81	279.0	COG0789@1|root,COG0789@2|Bacteria,2I8T8@201174|Actinobacteria,4D9G3@85008|Micromonosporales	201174|Actinobacteria	K	Regulatory protein, MerR	litR	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
TLS2_k127_5882898_5	1151126.AQYI01000007_gene1485	1.206e-20	101.0	COG5343@1|root,COG5343@2|Bacteria,2IM7X@201174|Actinobacteria,4FPW6@85023|Microbacteriaceae	201174|Actinobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
TLS2_k127_5882898_4	1150864.MILUP08_41348	1.249e-76	262.0	COG1595@1|root,COG1595@2|Bacteria,2IKQ7@201174|Actinobacteria,4DAY0@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	litS	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_5882898_2	263358.VAB18032_11045	7.885e-96	324.0	arCOG06227@1|root,2ZCRG@2|Bacteria,2I96P@201174|Actinobacteria,4D8X0@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
TLS2_k127_5901258_10	479432.Sros_7439	7.507e-157	503.0	COG0535@1|root,COG0535@2|Bacteria,2I1KR@201174|Actinobacteria,4ENHE@85012|Streptosporangiales	201174|Actinobacteria	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
TLS2_k127_5901258_29	479432.Sros_7442	1.239e-72	268.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4EFQA@85012|Streptosporangiales	201174|Actinobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_5901258_4	479432.Sros_7440	1.023e-251	790.0	COG1132@1|root,COG1132@2|Bacteria,2GJTA@201174|Actinobacteria,4EFRF@85012|Streptosporangiales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_5901258_0	479432.Sros_7441	0.0	1192.0	COG0515@1|root,COG4403@1|root,COG0515@2|Bacteria,COG4403@2|Bacteria,2GMRN@201174|Actinobacteria,4EHTH@85012|Streptosporangiales	201174|Actinobacteria	KLT	Lanthionine synthetase C-like protein	-	-	-	-	-	-	-	-	-	-	-	-	LANC_like,Pkinase
TLS2_k127_5901258_26	1068980.ARVW01000001_gene6246	1.431e-76	278.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4E847@85010|Pseudonocardiales	201174|Actinobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_5901258_14	479435.Kfla_4436	2.416e-110	365.0	COG1171@1|root,COG1171@2|Bacteria,2H4AS@201174|Actinobacteria,4DWSH@85009|Propionibacteriales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
TLS2_k127_5901258_24	1122611.KB903985_gene3798	1.622e-78	271.0	COG1335@1|root,COG1335@2|Bacteria,2HEJA@201174|Actinobacteria,4EK16@85012|Streptosporangiales	201174|Actinobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS2_k127_5901258_1	1386089.N865_02510	0.0	1147.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4FE8A@85021|Intrasporangiaceae	201174|Actinobacteria	EQ	Hydantoinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
TLS2_k127_5901258_2	1464048.JNZS01000003_gene1148	6.047e-321	994.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4DGZR@85008|Micromonosporales	201174|Actinobacteria	EQ	COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
TLS2_k127_5901258_7	1122611.KB903985_gene3801	8.282e-209	655.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4EIA0@85012|Streptosporangiales	201174|Actinobacteria	C	CoA-transferase family III	-	-	2.8.3.16,2.8.3.20	ko:K07749,ko:K18313	-	-	R10640,R10641	RC00014	ko00000,ko01000	-	-	-	CoA_transf_3
TLS2_k127_5901258_32	479432.Sros_6620	7.211e-55	204.0	COG1802@1|root,COG1802@2|Bacteria,2GMI2@201174|Actinobacteria,4EK5H@85012|Streptosporangiales	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_5901258_15	479432.Sros_6617	9.484e-109	361.0	COG0119@1|root,COG0119@2|Bacteria,2GKTP@201174|Actinobacteria,4EFX0@85012|Streptosporangiales	201174|Actinobacteria	E	HMGL-like	-	-	4.1.3.4,4.1.3.46	ko:K01640,ko:K18314	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090,R10674	RC00502,RC00503,RC01118,RC01205,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS2_k127_5901258_9	1121946.AUAX01000020_gene3046	7.102e-163	525.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	pla	GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009056,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0044238,GO:0071704,GO:1901575	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Lipase_bact_N
TLS2_k127_5901258_41	1179773.BN6_38190	1.297e-30	130.0	2BQ60@1|root,32J0G@2|Bacteria,2H8BY@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5901258_13	1122182.KB903834_gene6203	1.441e-112	379.0	COG0265@1|root,COG0265@2|Bacteria,2IE8E@201174|Actinobacteria,4DEH0@85008|Micromonosporales	201174|Actinobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,Trypsin_2
TLS2_k127_5901258_50	1463825.JNXC01000008_gene1303	2.691e-06	59.0	COG1680@1|root,COG1680@2|Bacteria,2H2SY@201174|Actinobacteria,4DXGA@85010|Pseudonocardiales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_5901258_27	1150864.MILUP08_45300	7.967e-75	259.0	COG0454@1|root,COG0456@2|Bacteria,2HU9W@201174|Actinobacteria,4DDB3@85008|Micromonosporales	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_5901258_36	219305.MCAG_04743	4.943e-42	156.0	COG2329@1|root,COG2329@2|Bacteria,2IM1Q@201174|Actinobacteria,4DEB5@85008|Micromonosporales	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	1.14.99.57	ko:K21481	-	-	-	-	ko00000,ko01000	-	-	-	ABM
TLS2_k127_5901258_17	561175.KB894097_gene359	6.119e-96	318.0	COG0778@1|root,COG0778@2|Bacteria,2GPB4@201174|Actinobacteria,4EPBI@85012|Streptosporangiales	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_5901258_12	105425.BBPL01000016_gene2534	4.658e-139	461.0	COG4403@1|root,COG4403@2|Bacteria,2GKVV@201174|Actinobacteria,2NI0D@228398|Streptacidiphilus	201174|Actinobacteria	V	Domain of unknown function (DUF4135)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4135,LANC_like
TLS2_k127_5901258_33	33876.JNXY01000040_gene6848	2.336e-54	208.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4DJRF@85008|Micromonosporales	201174|Actinobacteria	L	Toprim-like	-	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_2,Toprim_N
TLS2_k127_5901258_22	1133849.O3I_034050	2.777e-84	287.0	COG0684@1|root,COG0684@2|Bacteria,2I8VQ@201174|Actinobacteria,4G4K0@85025|Nocardiaceae	201174|Actinobacteria	H	Aldolase/RraA	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
TLS2_k127_5901258_35	1298863.AUEP01000017_gene4201	7.075e-45	166.0	COG3214@1|root,COG3214@2|Bacteria,2GP6G@201174|Actinobacteria,4DPMS@85009|Propionibacteriales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
TLS2_k127_5901258_6	1449976.KALB_6214	2.521e-214	674.0	COG0499@1|root,COG0499@2|Bacteria,2GK2Q@201174|Actinobacteria,4DXX6@85010|Pseudonocardiales	201174|Actinobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS2_k127_5901258_16	35754.JNYJ01000020_gene290	5.831e-107	353.0	COG2020@1|root,COG2020@2|Bacteria,2GN9N@201174|Actinobacteria,4DDTM@85008|Micromonosporales	201174|Actinobacteria	O	NnrU protein	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU
TLS2_k127_5901258_3	1120949.KB903303_gene6686	2.143e-274	865.0	COG2267@1|root,COG4671@1|root,COG2267@2|Bacteria,COG4671@2|Bacteria,2HU5Q@201174|Actinobacteria,4DBMT@85008|Micromonosporales	201174|Actinobacteria	I	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Glyco_tran_28_C
TLS2_k127_5901258_5	1123024.AUII01000001_gene2786	8.064e-215	712.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2IEE8@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Trans_reg_C
TLS2_k127_5901258_28	1122611.KB904022_gene7137	6.319e-74	251.0	COG2346@1|root,COG2346@2|Bacteria,2GMG5@201174|Actinobacteria	201174|Actinobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
TLS2_k127_5901258_31	1449976.KALB_4108	2.217e-63	224.0	COG3593@1|root,COG3593@2|Bacteria,2GMN5@201174|Actinobacteria,4E9X0@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA synthesis involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5901258_21	285535.JOEY01000012_gene5657	1.551e-87	296.0	COG0500@1|root,COG2226@2|Bacteria,2HVPX@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_5901258_37	1246995.AFR_34745	8.612e-39	147.0	2DNXR@1|root,32ZPP@2|Bacteria,2I2KW@201174|Actinobacteria,4DFBI@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905
TLS2_k127_5901258_18	479432.Sros_3245	4.579e-94	324.0	COG4585@1|root,COG4585@2|Bacteria,2GJ6F@201174|Actinobacteria,4EIK8@85012|Streptosporangiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS2_k127_5901258_19	1394178.AWOO02000093_gene8074	6.407e-92	317.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4EGA8@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_5901258_25	47716.JOFH01000030_gene6718	1.332e-77	271.0	COG1210@1|root,COG1210@2|Bacteria,2I39A@201174|Actinobacteria	201174|Actinobacteria	M	Alpha/beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_8
TLS2_k127_5901258_11	1122611.KB903954_gene5623	5.846e-154	505.0	COG4425@1|root,COG4425@2|Bacteria,2GKB5@201174|Actinobacteria,4ENPR@85012|Streptosporangiales	201174|Actinobacteria	S	Alpha/beta-hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_9,Abhydrolase_9_N
TLS2_k127_5901258_8	35754.JNYJ01000016_gene9308	3.353e-186	590.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria,4DARF@85008|Micromonosporales	201174|Actinobacteria	V	Beta-lactamase	lipP	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_5901258_23	1463881.KL591041_gene6330	6.779e-84	282.0	COG1357@1|root,COG3293@1|root,COG1357@2|Bacteria,COG3293@2|Bacteria,2GNJ9@201174|Actinobacteria	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
TLS2_k127_5901258_38	35754.JNYJ01000128_gene6369	2.036e-37	146.0	COG1357@1|root,COG3293@1|root,COG1357@2|Bacteria,COG3293@2|Bacteria,2GNJ9@201174|Actinobacteria,4DAK2@85008|Micromonosporales	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
TLS2_k127_5901258_51	66874.JOFS01000062_gene8378	1.261e-05	49.0	COG1357@1|root,COG1357@2|Bacteria,2GNJ9@201174|Actinobacteria	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
TLS2_k127_5901258_46	219305.MCAG_01185	3.648e-09	64.0	2AXHQ@1|root,30FPF@2|Bacteria,2IJ5A@201174|Actinobacteria,4DDZ0@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5901258_49	591157.SSLG_00202	1.235e-06	51.0	COG0346@1|root,COG0346@2|Bacteria,2IFMD@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5901258_44	1463825.JNXC01000032_gene1746	2.491e-14	74.0	COG0346@1|root,COG0346@2|Bacteria,2IFMD@201174|Actinobacteria,4E2W4@85010|Pseudonocardiales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5901258_34	134676.ACPL_3608	1.061e-48	176.0	COG1877@1|root,COG1877@2|Bacteria,2HVU5@201174|Actinobacteria,4DHUX@85008|Micromonosporales	201174|Actinobacteria	G	trehalose-phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5901258_20	1121924.ATWH01000025_gene1362	2.608e-90	308.0	COG0789@1|root,COG2764@1|root,COG0789@2|Bacteria,COG2764@2|Bacteria,2IQGQ@201174|Actinobacteria,4FPSH@85023|Microbacteriaceae	201174|Actinobacteria	K	MerR, DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_5901258_47	1389489.O159_13500	3.826e-09	63.0	2B4WS@1|root,31XPH@2|Bacteria,2GZD0@201174|Actinobacteria,4FQKP@85023|Microbacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5901258_30	58123.JOFJ01000008_gene414	7.991e-65	226.0	COG1569@1|root,COG1569@2|Bacteria,2GRT8@201174|Actinobacteria	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
TLS2_k127_5901258_45	1237500.ANBA01000008_gene263	9.105e-12	68.0	COG0346@1|root,COG0346@2|Bacteria,2IFMD@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5903271_44	134676.ACPL_1757	4.608e-18	87.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4D8G6@85008|Micromonosporales	201174|Actinobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2158c	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_5903271_5	263358.VAB18032_26826	2.464e-206	668.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4D9R7@85008|Micromonosporales	201174|Actinobacteria	M	penicillin-binding protein	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
TLS2_k127_5903271_41	219305.MCAG_01220	3.778e-20	96.0	COG2919@1|root,COG2919@2|Bacteria,2GTFA@201174|Actinobacteria,4DMN0@85008|Micromonosporales	201174|Actinobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5903271_19	1150864.MILUP08_45134	1.774e-128	418.0	COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria,4D97F@85008|Micromonosporales	201174|Actinobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
TLS2_k127_5903271_28	644283.Micau_4481	2.098e-73	253.0	COG2001@1|root,COG2001@2|Bacteria,2IHUB@201174|Actinobacteria,4DD2W@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
TLS2_k127_5903271_6	33876.JNXY01000044_gene1901	1.922e-200	633.0	COG0769@1|root,COG0769@2|Bacteria,2I2TV@201174|Actinobacteria,4DAEB@85008|Micromonosporales	201174|Actinobacteria	M	Domain of unknown function (DUF1727)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1727,Mur_ligase_M
TLS2_k127_5903271_21	134676.ACPL_1750	2.626e-110	361.0	COG3442@1|root,COG3442@2|Bacteria,2GKPV@201174|Actinobacteria,4DB13@85008|Micromonosporales	201174|Actinobacteria	S	glutamine amidotransferase	cobQ2	-	-	ko:K07009	-	-	-	-	ko00000	-	-	-	GATase_3
TLS2_k127_5903271_2	1347087.CBYO010000016_gene2628	0.0	1262.0	COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Inhibitor_I9,PQQ_2,PQQ_3,Peptidase_S8
TLS2_k127_5903271_38	1136417.AZWE01000020_gene4121	6.453e-32	129.0	COG1944@1|root,COG1944@2|Bacteria,2GKBS@201174|Actinobacteria,4DBX7@85008|Micromonosporales	201174|Actinobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
TLS2_k127_5903271_16	1121272.KB903254_gene6586	1.02e-136	442.0	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria,4DF4Z@85008|Micromonosporales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_5903271_40	561175.KB894093_gene2960	8.911e-22	107.0	2E384@1|root,32Y7U@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K18546	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Trypsin
TLS2_k127_5903271_7	1246995.AFR_42740	1.346e-199	650.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4D91T@85008|Micromonosporales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
TLS2_k127_5903271_1	644283.Micau_4485	0.0	1521.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4DAJQ@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
TLS2_k127_5903271_11	1173024.KI912149_gene5720	1.673e-165	532.0	28J3E@1|root,2Z8ZN@2|Bacteria,1G4GM@1117|Cyanobacteria,1JJ8X@1189|Stigonemataceae	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5903271_26	1254432.SCE1572_50795	2.372e-75	265.0	COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,43BR5@68525|delta/epsilon subdivisions,2X725@28221|Deltaproteobacteria,2YTYE@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_5903271_12	1429046.RR21198_0068	3.832e-163	529.0	COG0596@1|root,COG0596@2|Bacteria,2GKX3@201174|Actinobacteria,4FZTX@85025|Nocardiaceae	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5903271_10	219305.MCAG_01227	2.151e-179	567.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4D9JV@85008|Micromonosporales	201174|Actinobacteria	S	ATPase associated with various cellular activities	yeaC	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_5903271_8	1150864.MILUP08_45142	2.114e-199	629.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4DB81@85008|Micromonosporales	201174|Actinobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_5903271_4	644283.Micau_4488	1.815e-209	689.0	COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria,4DC6C@85008|Micromonosporales	201174|Actinobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
TLS2_k127_5903271_37	1120949.KB903302_gene6671	1.462e-39	155.0	2E49S@1|root,32Z5G@2|Bacteria,2IHN1@201174|Actinobacteria,4DDBZ@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3040
TLS2_k127_5903271_9	644283.Micau_4490	5.022e-189	597.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4D8ZI@85008|Micromonosporales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
TLS2_k127_5903271_13	644283.Micau_4491	2.503e-148	479.0	COG1524@1|root,COG1524@2|Bacteria,2GISU@201174|Actinobacteria,4D8R9@85008|Micromonosporales	201174|Actinobacteria	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_5903271_23	1246995.AFR_09900	2.827e-83	283.0	COG2227@1|root,COG2227@2|Bacteria,2GMAR@201174|Actinobacteria,4D9KB@85008|Micromonosporales	201174|Actinobacteria	H	Methyltransferase	smtA	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25
TLS2_k127_5903271_43	419947.MRA_2623A	2.917e-18	86.0	COG2002@1|root,COG2002@2|Bacteria,2HANT@201174|Actinobacteria	201174|Actinobacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5903271_35	656024.FsymDg_2935	3.917e-42	160.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_5903271_0	35754.JNYJ01000104_gene1578	0.0	1557.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4D8EW@85008|Micromonosporales	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS2_k127_5903271_3	356851.JOAN01000010_gene4646	7.807e-220	698.0	COG0389@1|root,COG0389@2|Bacteria,2GMZ3@201174|Actinobacteria,4D9AC@85008|Micromonosporales	201174|Actinobacteria	L	impB/mucB/samB family	dinB_2	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
TLS2_k127_5903271_32	644283.Micau_4496	2.751e-57	210.0	COG4544@1|root,COG4544@2|Bacteria,2IIXE@201174|Actinobacteria,4DA6N@85008|Micromonosporales	201174|Actinobacteria	S	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	-	GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5903271_34	356851.JOAN01000010_gene4644	9.997e-56	199.0	2CGM3@1|root,32S47@2|Bacteria,2GP7H@201174|Actinobacteria,4DDF2@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5903271_18	263358.VAB18032_03290	8.818e-129	430.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4DEDW@85008|Micromonosporales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_5903271_17	405948.SACE_3979	6.23e-130	425.0	COG0142@1|root,COG0142@2|Bacteria,2GN1P@201174|Actinobacteria,4DX7Q@85010|Pseudonocardiales	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_5903271_31	263358.VAB18032_26931	5.209e-63	235.0	COG2606@1|root,COG2606@2|Bacteria,2IKUX@201174|Actinobacteria,4DDTN@85008|Micromonosporales	201174|Actinobacteria	S	YbaK prolyl-tRNA synthetase associated	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
TLS2_k127_5903271_22	263358.VAB18032_26941	1.684e-86	289.0	COG0454@1|root,COG0456@2|Bacteria,2GM3A@201174|Actinobacteria,4DBGW@85008|Micromonosporales	201174|Actinobacteria	K	Gcn5-related n-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
TLS2_k127_5903271_39	1246995.AFR_09730	7.713e-28	121.0	COG0558@1|root,COG0558@2|Bacteria,2IDSP@201174|Actinobacteria,4DC0V@85008|Micromonosporales	201174|Actinobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_5903271_14	219305.MCAG_01242	5.662e-146	473.0	COG0685@1|root,COG0685@2|Bacteria,2GJTN@201174|Actinobacteria,4DB75@85008|Micromonosporales	201174|Actinobacteria	E	5,10-methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS2_k127_5903271_27	33876.JNXY01000009_gene8905	1.71e-73	256.0	COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria,4DHU5@85008|Micromonosporales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TLS2_k127_5903271_33	285514.JNWO01000003_gene6752	7.154e-56	205.0	COG0500@1|root,COG2226@2|Bacteria,2GM9H@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS2_k127_5903271_30	512565.AMIS_30980	5.58e-65	236.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TLS2_k127_5903271_29	644283.Micau_5475	8.148e-73	262.0	COG0683@1|root,COG0683@2|Bacteria,2GNVF@201174|Actinobacteria,4D9DR@85008|Micromonosporales	201174|Actinobacteria	E	Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_5903271_42	1206737.BAGF01000049_gene2946	9.15e-19	100.0	COG1396@1|root,COG1396@2|Bacteria,2IBRM@201174|Actinobacteria,4FY0E@85025|Nocardiaceae	201174|Actinobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5903271_20	1206743.BAGM01000202_gene1106	1.442e-111	377.0	COG0252@1|root,COG0252@2|Bacteria,2HUB2@201174|Actinobacteria,4FUU5@85025|Nocardiaceae	201174|Actinobacteria	EJ	Asparaginase	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
TLS2_k127_5903271_24	33876.JNXY01000013_gene4088	4.359e-82	294.0	COG1396@1|root,COG1476@1|root,COG1396@2|Bacteria,COG1476@2|Bacteria,2GNDR@201174|Actinobacteria,4DFKI@85008|Micromonosporales	201174|Actinobacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
TLS2_k127_5903271_15	219305.MCAG_01243	1.402e-143	463.0	COG0142@1|root,COG0142@2|Bacteria,2GJEK@201174|Actinobacteria,4D8QG@85008|Micromonosporales	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_5903271_36	1150864.MILUP08_45166	2.466e-40	160.0	2E0H9@1|root,32W34@2|Bacteria,2IHPW@201174|Actinobacteria,4DE20@85008|Micromonosporales	201174|Actinobacteria	S	transcriptional regulator	-	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010565,GO:0016310,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5903271_25	649831.L083_1964	1.956e-80	273.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4D8KT@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_5993379_55	986075.CathTA2_1322	1.95e-42	162.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4HE36@91061|Bacilli	91061|Bacilli	G	C4-dicarboxylate ABC transporter permease	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_5993379_40	69328.PVLB_04025	1.458e-84	290.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,1RRVQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_5993379_48	882083.SacmaDRAFT_2515	6.063e-66	228.0	COG2030@1|root,COG2030@2|Bacteria,2IHRG@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS2_k127_5993379_30	1463825.JNXC01000008_gene1343	5.354e-140	451.0	COG2159@1|root,COG2159@2|Bacteria,2GMQY@201174|Actinobacteria,4DZEJ@85010|Pseudonocardiales	201174|Actinobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_5993379_21	1068980.ARVW01000001_gene1574	6.941e-167	540.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DZX5@85010|Pseudonocardiales	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_5993379_33	263358.VAB18032_10835	5.658e-123	410.0	COG3327@1|root,COG3327@2|Bacteria,2GNME@201174|Actinobacteria,4DB32@85008|Micromonosporales	201174|Actinobacteria	K	PaaX-like protein	-	-	-	ko:K02616	-	-	-	-	ko00000,ko03000	-	-	-	PaaX,PaaX_C
TLS2_k127_5993379_7	1380370.JIBA01000001_gene2254	9.399e-237	742.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria,4FIVI@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA polymerase Ligase (LigD)	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS2_k127_5993379_10	35754.JNYJ01000046_gene3102	6.534e-211	666.0	COG1520@1|root,COG1520@2|Bacteria,2I9S4@201174|Actinobacteria,4D97G@85008|Micromonosporales	201174|Actinobacteria	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TLS2_k127_5993379_49	1869.MB27_05285	2.306e-64	229.0	COG1028@1|root,COG1028@2|Bacteria,2GKVM@201174|Actinobacteria,4DJ9D@85008|Micromonosporales	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_5993379_51	356851.JOAN01000002_gene858	1.156e-62	224.0	COG2197@1|root,COG2197@2|Bacteria,2GR7V@201174|Actinobacteria,4DG2P@85008|Micromonosporales	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_5993379_18	1160137.KB907307_gene424	8.123e-173	549.0	COG0436@1|root,COG0436@2|Bacteria,2GNJV@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS2_k127_5993379_19	2002.JOEQ01000032_gene1750	1.571e-170	548.0	COG2175@1|root,COG2175@2|Bacteria,2GSEY@201174|Actinobacteria,4ENXY@85012|Streptosporangiales	201174|Actinobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016705,GO:0016706,GO:0051213,GO:0055114	1.14.11.40	ko:K20157	-	-	-	-	ko00000,ko01000	-	-	-	TauD
TLS2_k127_5993379_16	2002.JOEQ01000032_gene1762	1.385e-180	574.0	COG0436@1|root,COG0436@2|Bacteria,2GMI8@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS2_k127_5993379_15	1160137.KB907307_gene413	4.519e-186	593.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4FW9P@85025|Nocardiaceae	201174|Actinobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_5993379_22	1160137.KB907307_gene412	1.787e-163	520.0	COG2141@1|root,COG2141@2|Bacteria,2IEXD@201174|Actinobacteria,4FYDB@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase,KR,PP-binding,PS-DH
TLS2_k127_5993379_3	2002.JOEQ01000032_gene1765	0.0	1553.0	COG1020@1|root,COG1020@2|Bacteria,2IE95@201174|Actinobacteria	201174|Actinobacteria	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
TLS2_k127_5993379_13	1160137.KB907307_gene410	2.317e-189	601.0	COG0436@1|root,COG0436@2|Bacteria,2I8Z8@201174|Actinobacteria	201174|Actinobacteria	E	aminotransferase class I and II	arcT	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS2_k127_5993379_56	356851.JOAN01000002_gene899	1.501e-30	124.0	COG3251@1|root,COG3251@2|Bacteria,2GQFU@201174|Actinobacteria,4DFK5@85008|Micromonosporales	201174|Actinobacteria	S	MbtH-like protein	-	-	-	ko:K05375	ko00261,ko01130,map00261,map01130	M00736	R10880	RC00064,RC00141,RC03296,RC03297,RC03298	ko00000,ko00001,ko00002	-	-	-	MbtH
TLS2_k127_5993379_37	1160137.KB907307_gene419	4.367e-95	317.0	COG3208@1|root,COG3208@2|Bacteria,2GMY8@201174|Actinobacteria,4FXT9@85025|Nocardiaceae	201174|Actinobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioesterase
TLS2_k127_5993379_0	1160137.KB907307_gene418	0.0	2122.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4FUGV@85025|Nocardiaceae	201174|Actinobacteria	Q	Peptide synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
TLS2_k127_5993379_2	1160137.KB907307_gene418	0.0	1615.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4FUGV@85025|Nocardiaceae	201174|Actinobacteria	Q	Peptide synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
TLS2_k127_5993379_43	1298863.AUEP01000002_gene1559	3.723e-77	266.0	COG1247@1|root,COG1247@2|Bacteria,2II0A@201174|Actinobacteria,4DR4S@85009|Propionibacteriales	201174|Actinobacteria	M	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5993379_47	1160137.KB907307_gene416	9.531e-70	254.0	COG0477@1|root,COG0477@2|Bacteria,2I51W@201174|Actinobacteria	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_5993379_14	479433.Caci_3438	7.411e-188	616.0	COG1020@1|root,COG1020@2|Bacteria,2ID2C@201174|Actinobacteria	201174|Actinobacteria	Q	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_5993379_27	356851.JOAN01000002_gene872	1.084e-142	476.0	COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,4DCRF@85008|Micromonosporales	201174|Actinobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_5993379_39	1160137.KB907307_gene409	2.191e-86	294.0	COG3208@1|root,COG3208@2|Bacteria,2GMY8@201174|Actinobacteria,4FUWU@85025|Nocardiaceae	201174|Actinobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioesterase
TLS2_k127_5993379_4	1160137.KB907307_gene433	0.0	1220.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4FUGV@85025|Nocardiaceae	201174|Actinobacteria	Q	Peptide synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
TLS2_k127_5993379_23	356851.JOAN01000002_gene865	5.506e-156	505.0	COG0477@1|root,COG0477@2|Bacteria,2I61E@201174|Actinobacteria	201174|Actinobacteria	EGP	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_5993379_32	356851.JOAN01000002_gene867	1.19e-133	434.0	COG2141@1|root,COG2141@2|Bacteria,2GJI7@201174|Actinobacteria,4DIPA@85008|Micromonosporales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_5993379_46	43759.JNWK01000032_gene4231	1.974e-71	254.0	COG2154@1|root,COG2154@2|Bacteria,2IHZE@201174|Actinobacteria	201174|Actinobacteria	H	dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
TLS2_k127_5993379_50	356851.JOAN01000002_gene873	2.354e-64	224.0	COG0346@1|root,COG0346@2|Bacteria,2IMFW@201174|Actinobacteria,4DJB5@85008|Micromonosporales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_5993379_41	356851.JOAN01000002_gene874	2.195e-83	288.0	2EYJY@1|root,33RTN@2|Bacteria,2IDR1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5993379_5	356851.JOAN01000002_gene875	3.677e-275	857.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4DCJX@85008|Micromonosporales	201174|Actinobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_5993379_25	1894.JOER01000005_gene2627	4.768e-151	488.0	COG2008@1|root,COG2008@2|Bacteria,2GMNV@201174|Actinobacteria	201174|Actinobacteria	E	Threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_5993379_44	1169154.KB897785_gene1217	7.091e-75	271.0	COG2175@1|root,COG2175@2|Bacteria,2HE90@201174|Actinobacteria	201174|Actinobacteria	Q	taurine catabolism dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	TauD
TLS2_k127_5993379_12	1133850.SHJG_7062	2.003e-190	624.0	COG1020@1|root,COG3208@1|root,COG1020@2|Bacteria,COG3208@2|Bacteria	2|Bacteria	Q	Thioesterase involved in non-ribosomal peptide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
TLS2_k127_5993379_35	1968.JOEV01000007_gene4025	1.042e-116	385.0	COG0031@1|root,COG0031@2|Bacteria,2GK6J@201174|Actinobacteria	201174|Actinobacteria	E	cysteine synthase	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_5993379_34	65497.JODV01000025_gene1877	7.902e-123	424.0	COG0165@1|root,COG0165@2|Bacteria,2IAPS@201174|Actinobacteria,4E031@85010|Pseudonocardiales	201174|Actinobacteria	E	Lyase	-	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
TLS2_k127_5993379_38	68199.JNZO01000020_gene7126	5.988e-88	316.0	COG1821@1|root,COG1821@2|Bacteria	2|Bacteria	GM	Pfam ATP-grasp domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_3,ATP-grasp_4,Acetyltransf_10
TLS2_k127_5993379_45	1463864.JOGO01000026_gene2786	2.267e-72	259.0	COG1020@1|root,COG2175@1|root,COG1020@2|Bacteria,COG2175@2|Bacteria,2GISR@201174|Actinobacteria	201174|Actinobacteria	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,TauD
TLS2_k127_5993379_42	1289387.AUKW01000006_gene3864	1.554e-82	285.0	COG4542@1|root,COG4542@2|Bacteria,2I8UM@201174|Actinobacteria	201174|Actinobacteria	Q	COG4542 Protein involved in propanediol utilization, and related proteins includes coumermycin biosynthetic protein	-	-	2.7.1.177	ko:K16651	ko00860,map00860	-	R06531	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_5993379_9	47716.JOFH01000027_gene2906	3.052e-214	706.0	COG1020@1|root,COG3208@1|root,COG1020@2|Bacteria,COG3208@2|Bacteria	2|Bacteria	Q	Thioesterase involved in non-ribosomal peptide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
TLS2_k127_5993379_6	356851.JOAN01000002_gene886	2.507e-263	861.0	COG1020@1|root,COG1020@2|Bacteria,2IEVV@201174|Actinobacteria	201174|Actinobacteria	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	Condensation,PP-binding
TLS2_k127_5993379_29	1160137.KB907307_gene430	5.305e-140	457.0	COG2267@1|root,COG2267@2|Bacteria,2IDX5@201174|Actinobacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_5993379_26	644283.Micau_3879	2.987e-144	463.0	COG5285@1|root,COG5285@2|Bacteria,2GPSA@201174|Actinobacteria,4DKJ9@85008|Micromonosporales	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	ko:K15650	-	-	-	-	ko00000,ko01008	-	-	-	PhyH
TLS2_k127_5993379_61	1441629.PCH70_25950	0.0005221	45.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,TauD
TLS2_k127_5993379_1	1160137.KB907307_gene428	0.0	1867.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4FUGV@85025|Nocardiaceae	201174|Actinobacteria	Q	Peptide synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
TLS2_k127_5993379_8	1160137.KB907307_gene427	6.914e-228	722.0	COG0318@1|root,COG1020@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,2GISR@201174|Actinobacteria	201174|Actinobacteria	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl-CoA_dh_1,Acyl-CoA_dh_M,Condensation,PP-binding
TLS2_k127_5993379_52	1077972.ARGLB_039_00800	3.476e-56	198.0	COG0346@1|root,COG0346@2|Bacteria,2HTKK@201174|Actinobacteria,1WBPU@1268|Micrococcaceae	201174|Actinobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5993379_53	1150864.MILUP08_42863	8.975e-47	183.0	COG1853@1|root,COG1853@2|Bacteria,2GYGX@201174|Actinobacteria,4DE2D@85008|Micromonosporales	201174|Actinobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TLS2_k127_5993379_36	566461.SSFG_00213	2.076e-96	334.0	COG0388@1|root,COG0388@2|Bacteria,2GM49@201174|Actinobacteria	201174|Actinobacteria	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS2_k127_5993379_57	465541.ATCJ01000005_gene1340	2.724e-12	74.0	2B7J0@1|root,320PJ@2|Bacteria,2H4G4@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5993379_54	512565.AMIS_49560	2.871e-45	167.0	COG0346@1|root,COG0346@2|Bacteria,2IFBN@201174|Actinobacteria,4DGJ9@85008|Micromonosporales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_5993379_17	1120949.KB903314_gene325	1.074e-177	567.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4DEDW@85008|Micromonosporales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_5993379_20	134676.ACPL_4738	4.035e-169	535.0	COG2267@1|root,COG2267@2|Bacteria,2H83P@201174|Actinobacteria,4D8FM@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
TLS2_k127_5993379_28	1385519.N801_12795	6.811e-141	477.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
TLS2_k127_5993379_58	66373.JOFQ01000012_gene6193	8.693e-10	73.0	COG0671@1|root,COG0671@2|Bacteria,2I9FB@201174|Actinobacteria	201174|Actinobacteria	I	Phosphoesterase, PA-phosphatase related	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
TLS2_k127_5993379_24	1206732.BAGD01000277_gene6244	8.311e-156	529.0	COG3540@1|root,COG3540@2|Bacteria,2IMZY@201174|Actinobacteria	201174|Actinobacteria	P	PhoD-like phosphatase	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD
TLS2_k127_5993379_59	479435.Kfla_6045	4.036e-09	68.0	COG3187@1|root,COG3187@2|Bacteria,2I9ND@201174|Actinobacteria,4DUY5@85009|Propionibacteriales	201174|Actinobacteria	O	META domain	hslJ	-	-	ko:K03668	-	-	-	-	ko00000	-	-	-	META
TLS2_k127_5993379_31	1123024.AUII01000015_gene3750	3.828e-138	453.0	COG0654@1|root,COG0654@2|Bacteria,2GK7I@201174|Actinobacteria,4DXC9@85010|Pseudonocardiales	201174|Actinobacteria	CH	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_binding_3,FAD_oxidored
TLS2_k127_5993379_11	471852.Tcur_2984	1.869e-203	657.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Abhydrolase_1,GerE,Trans_reg_C
TLS2_k127_6005608_5	1150864.MILUP08_45067	1.886e-224	701.0	COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,4D9UG@85008|Micromonosporales	201174|Actinobacteria	E	Glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
TLS2_k127_6005608_0	1150864.MILUP08_45068	0.0	2441.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria,4DA4C@85008|Micromonosporales	201174|Actinobacteria	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TLS2_k127_6005608_20	1150864.MILUP08_45070	2.407e-128	424.0	COG0654@1|root,COG0654@2|Bacteria,2GIZU@201174|Actinobacteria,4D9V3@85008|Micromonosporales	201174|Actinobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS2_k127_6005608_22	644283.Micau_4420	1.327e-122	406.0	COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria,4DBJJ@85008|Micromonosporales	201174|Actinobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	-	-	-	-	-	-	-	-	-	LGT
TLS2_k127_6005608_34	35754.JNYJ01000001_gene7130	2.384e-55	199.0	COG1051@1|root,COG1051@2|Bacteria,2GPIQ@201174|Actinobacteria,4DFF0@85008|Micromonosporales	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_6005608_26	219305.MCAG_01171	7.987e-107	353.0	COG0159@1|root,COG0159@2|Bacteria,2GN6T@201174|Actinobacteria,4D94W@85008|Micromonosporales	201174|Actinobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
TLS2_k127_6005608_6	390989.JOEG01000008_gene1301	1e-209	658.0	COG0133@1|root,COG0133@2|Bacteria,2GM7Z@201174|Actinobacteria,4DAJZ@85008|Micromonosporales	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PALP
TLS2_k127_6005608_21	1246995.AFR_10305	2.885e-125	413.0	COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,4D91A@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the TrpC family	trpC	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
TLS2_k127_6005608_39	33876.JNXY01000044_gene1840	2.692e-31	129.0	2EGC7@1|root,33A40@2|Bacteria,2HEC9@201174|Actinobacteria,4DEKU@85008|Micromonosporales	201174|Actinobacteria	S	Tryptophan-associated transmembrane protein (Trp_oprn_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Trp_oprn_chp
TLS2_k127_6005608_4	1246995.AFR_10290	1.311e-246	771.0	COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4D8F7@85008|Micromonosporales	201174|Actinobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS2_k127_6005608_32	1120949.KB903308_gene1217	1.527e-58	206.0	COG0139@1|root,COG0139@2|Bacteria,2IKKU@201174|Actinobacteria,4DDD9@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	GO:0008150,GO:0040007	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1606	PRA-CH
TLS2_k127_6005608_42	33876.JNXY01000044_gene1843	2.897e-22	108.0	COG0508@1|root,COG0508@2|Bacteria,2GTGN@201174|Actinobacteria,4DFZY@85008|Micromonosporales	201174|Actinobacteria	C	dehydrogenase complex catalyzes the overall conversion of	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6005608_2	263358.VAB18032_26631	2.603e-268	837.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4DAZZ@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K02021,ko:K06147,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_membrane,ABC_tran
TLS2_k127_6005608_3	369723.Strop_3181	5.604e-260	815.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4DA6J@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
TLS2_k127_6005608_1	263358.VAB18032_26651	2.899e-295	916.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4D91C@85008|Micromonosporales	201174|Actinobacteria	I	AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS2_k127_6005608_38	1206725.BAFU01000044_gene2056	1.031e-36	154.0	2B0XT@1|root,31TAQ@2|Bacteria,2GWC5@201174|Actinobacteria,4FVP3@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6005608_23	1122138.AQUZ01000010_gene5055	3.726e-121	392.0	COG0107@1|root,COG0107@2|Bacteria,2GIRP@201174|Actinobacteria,4DPEF@85009|Propionibacteriales	201174|Actinobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007	4.1.3.27	ko:K01657,ko:K02500	ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023,M00026	R00985,R00986,R04558	RC00010,RC01190,RC01943,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS2_k127_6005608_24	263358.VAB18032_26686	9.671e-116	377.0	COG0106@1|root,COG0106@2|Bacteria,2GJ4V@201174|Actinobacteria,4D8GE@85008|Micromonosporales	201174|Actinobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16,5.3.1.24	ko:K01814,ko:K01817	ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230	M00023,M00026	R03509,R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS2_k127_6005608_28	391037.Sare_3418	8.791e-81	280.0	COG0118@1|root,COG0118@2|Bacteria,2GIYS@201174|Actinobacteria,4DBQ6@85008|Micromonosporales	201174|Actinobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS2_k127_6005608_27	263358.VAB18032_26706	2.154e-93	313.0	COG0131@1|root,COG0131@2|Bacteria,2GKMD@201174|Actinobacteria,4D8JJ@85008|Micromonosporales	201174|Actinobacteria	E	Imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,4.2.1.19	ko:K01089,ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013,R03457	RC00017,RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
TLS2_k127_6005608_14	644283.Micau_4454	1.922e-165	531.0	COG0079@1|root,COG0079@2|Bacteria,2GJ9W@201174|Actinobacteria,4DAAT@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_6005608_15	33876.JNXY01000044_gene1873	3.562e-165	529.0	COG0141@1|root,COG0141@2|Bacteria,2GKKA@201174|Actinobacteria,4DA72@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1599	Histidinol_dh
TLS2_k127_6005608_36	1136417.AZWE01000002_gene3635	1.423e-43	168.0	2EGQJ@1|root,33AGQ@2|Bacteria,2IHWM@201174|Actinobacteria,4DD33@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF2567)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2567
TLS2_k127_6005608_19	1136417.AZWE01000002_gene3634	3.349e-132	436.0	COG0455@1|root,COG0455@2|Bacteria,2GMK0@201174|Actinobacteria,4DB1J@85008|Micromonosporales	201174|Actinobacteria	D	Involved in chromosome	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
TLS2_k127_6005608_18	263358.VAB18032_26741	2.953e-148	473.0	COG0564@1|root,COG0564@2|Bacteria,2GIY1@201174|Actinobacteria,4D8KE@85008|Micromonosporales	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_6005608_35	1464048.JNZS01000014_gene3069	1.219e-53	199.0	COG0597@1|root,COG0597@2|Bacteria,2GKRX@201174|Actinobacteria,4DD40@85008|Micromonosporales	201174|Actinobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
TLS2_k127_6005608_31	1150864.MILUP08_45114	3.555e-60	216.0	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4DDBG@85008|Micromonosporales	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
TLS2_k127_6005608_9	1464048.JNZS01000014_gene3071	1.774e-190	607.0	COG3263@1|root,COG3263@2|Bacteria,2GJ9B@201174|Actinobacteria,4D9E3@85008|Micromonosporales	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	cvrA	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger,TrkA_C
TLS2_k127_6005608_41	649831.L083_2028	4.414e-27	114.0	COG1872@1|root,COG1872@2|Bacteria,2GQSC@201174|Actinobacteria,4DFQ8@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
TLS2_k127_6005608_37	1121272.KB903255_gene5827	5.964e-42	163.0	2E42E@1|root,32YYX@2|Bacteria,2IQSB@201174|Actinobacteria,4DEDF@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	ko:K14201	ko05150,map05150	-	-	-	ko00000,ko00001	-	-	-	-
TLS2_k127_6005608_25	219305.MCAG_01207	6.65e-112	368.0	COG3599@1|root,COG3599@2|Bacteria,2GMSC@201174|Actinobacteria,4DB3S@85008|Micromonosporales	201174|Actinobacteria	D	Cell division initiation protein	wag31	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0022603,GO:0022604,GO:0030312,GO:0031647,GO:0040007,GO:0042546,GO:0044085,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050821,GO:0051128,GO:0060187,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944	-	-	-	-	-	-	-	-	-	-	DivIVA
TLS2_k127_6005608_40	219305.MCAG_01208	3.241e-30	122.0	COG0762@1|root,COG0762@2|Bacteria,2GQI1@201174|Actinobacteria,4DEYY@85008|Micromonosporales	201174|Actinobacteria	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
TLS2_k127_6005608_30	1246995.AFR_10035	1.291e-67	237.0	COG1799@1|root,COG1799@2|Bacteria,2GNVH@201174|Actinobacteria,4DAXQ@85008|Micromonosporales	201174|Actinobacteria	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
TLS2_k127_6005608_29	369723.Strop_3209	1.315e-76	273.0	COG0325@1|root,COG0325@2|Bacteria,2GMRJ@201174|Actinobacteria,4DCR9@85008|Micromonosporales	201174|Actinobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
TLS2_k127_6005608_8	35754.JNYJ01000001_gene7078	6.541e-205	640.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria,4D9T0@85008|Micromonosporales	201174|Actinobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS2_k127_6005608_33	543632.JOJL01000021_gene1290	2.654e-58	211.0	COG1589@1|root,COG1589@2|Bacteria,2H4A4@201174|Actinobacteria,4DDA4@85008|Micromonosporales	201174|Actinobacteria	D	Cell division protein FtsQ	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
TLS2_k127_6005608_7	1121272.KB903255_gene5820	7.023e-209	658.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4D99H@85008|Micromonosporales	201174|Actinobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_6005608_11	644283.Micau_4473	9.317e-175	556.0	COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria,4DAVC@85008|Micromonosporales	201174|Actinobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
TLS2_k127_6005608_17	356851.JOAN01000010_gene4667	3.467e-156	506.0	COG0772@1|root,COG0772@2|Bacteria,2GKXP@201174|Actinobacteria,4D8GC@85008|Micromonosporales	201174|Actinobacteria	D	Belongs to the SEDS family	ftsW	GO:0008150,GO:0040007	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28	-	FTSW_RODA_SPOVE
TLS2_k127_6005608_13	390989.JOEG01000008_gene1338	2.021e-166	536.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4D91Y@85008|Micromonosporales	201174|Actinobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2155c	AlaDh_PNT_C,Mur_ligase_C,Mur_ligase_M
TLS2_k127_6005608_12	1464048.JNZS01000014_gene3082	2.296e-169	540.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,4D9PX@85008|Micromonosporales	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0008150,GO:0040007	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
TLS2_k127_6005608_16	1246995.AFR_09995	4.207e-165	531.0	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,4DBRT@85008|Micromonosporales	201174|Actinobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_6005608_10	1246995.AFR_09990	1.301e-178	568.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4D8G6@85008|Micromonosporales	201174|Actinobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2158c	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_6013397_4	446470.Snas_5663	3.323e-124	406.0	COG1454@1|root,COG1454@2|Bacteria,2I2FD@201174|Actinobacteria,4EZBS@85014|Glycomycetales	201174|Actinobacteria	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
TLS2_k127_6013397_2	1463821.JOGR01000003_gene1116	9.725e-157	509.0	COG0028@1|root,COG0028@2|Bacteria,2GMIJ@201174|Actinobacteria,4EZ8M@85014|Glycomycetales	201174|Actinobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R04053	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
TLS2_k127_6013397_0	1313172.YM304_30130	3.638e-227	709.0	COG0615@1|root,COG2513@1|root,COG0615@2|Bacteria,COG2513@2|Bacteria,2GJZZ@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	-	-	5.4.2.9	ko:K01841	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R00661	RC02792	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,PEP_mutase
TLS2_k127_6013397_7	589865.DaAHT2_1096	5.02e-17	88.0	COG0457@1|root,COG0457@2|Bacteria,1Q0TI@1224|Proteobacteria,431FZ@68525|delta/epsilon subdivisions,2WX2R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
TLS2_k127_6013397_1	471852.Tcur_2962	1.609e-206	651.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4EI99@85012|Streptosporangiales	201174|Actinobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_6013397_6	1150399.AQYK01000001_gene15	5.793e-20	97.0	COG3548@1|root,COG3548@2|Bacteria,2IQG2@201174|Actinobacteria,4FPAK@85023|Microbacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
TLS2_k127_6013397_3	369723.Strop_4488	2.315e-148	477.0	COG0371@1|root,COG0371@2|Bacteria,2GKWA@201174|Actinobacteria,4DBA1@85008|Micromonosporales	201174|Actinobacteria	C	3-dehydroquinate synthase	gldA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
TLS2_k127_6013397_5	797299.HALLA_03760	6.35e-76	267.0	COG0697@1|root,arCOG00271@2157|Archaea,2XY2J@28890|Euryarchaeota,23Z1Z@183963|Halobacteria	183963|Halobacteria	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_6013464_3	644283.Micau_2080	4.968e-126	413.0	COG1887@1|root,COG1887@2|Bacteria,2H6EP@201174|Actinobacteria,4DBXE@85008|Micromonosporales	201174|Actinobacteria	M	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyphos_transf
TLS2_k127_6013464_6	446470.Snas_0891	2.083e-112	373.0	COG1213@1|root,COG1213@2|Bacteria,2GN1Y@201174|Actinobacteria,4EY5W@85014|Glycomycetales	201174|Actinobacteria	M	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
TLS2_k127_6013464_2	446470.Snas_0890	2.611e-135	444.0	COG0457@1|root,COG3475@1|root,COG0457@2|Bacteria,COG3475@2|Bacteria	2|Bacteria	M	LICD family	licD	-	-	ko:K02011,ko:K07271,ko:K19872	ko00515,ko01100,ko02010,map00515,map01100,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko04131	3.A.1.10	-	-	LicD
TLS2_k127_6013464_12	446470.Snas_0746	1.273e-59	229.0	COG0500@1|root,COG0500@2|Bacteria,2ID83@201174|Actinobacteria,4EZKV@85014|Glycomycetales	201174|Actinobacteria	Q	LicD family	-	-	-	-	-	-	-	-	-	-	-	-	LicD,Methyltransf_25
TLS2_k127_6013464_14	316274.Haur_0199	7.132e-43	164.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	dinB	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB
TLS2_k127_6013464_5	469371.Tbis_0635	1.64e-114	387.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gt2F	-	2.4.1.175,2.4.1.226	ko:K13500	ko00532,ko01100,map00532,map01100	-	R04603,R05931,R05932,R05933,R05934,R07336	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glyco_transf_7C,Glycos_transf_2
TLS2_k127_6013464_0	1121946.AUAX01000005_gene5406	2.3e-297	921.0	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4DBB5@85008|Micromonosporales	201174|Actinobacteria	I	carboxylase	bccA	-	6.3.4.14,6.4.1.2,6.4.1.3	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
TLS2_k127_6013464_7	1394178.AWOO02000017_gene6677	1.015e-103	352.0	COG3315@1|root,COG3315@2|Bacteria,2GMBA@201174|Actinobacteria,4EFKV@85012|Streptosporangiales	201174|Actinobacteria	Q	S-adenosyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_19
TLS2_k127_6013464_4	391037.Sare_2232	1.039e-120	395.0	COG1396@1|root,COG1396@2|Bacteria,2GIVR@201174|Actinobacteria,4D8TS@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
TLS2_k127_6013464_16	35754.JNYJ01000021_gene426	3.456e-27	118.0	2E6IT@1|root,3315W@2|Bacteria,2GR2R@201174|Actinobacteria,4DFKV@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF397
TLS2_k127_6013464_10	1136417.AZWE01000073_gene4174	1.618e-69	243.0	COG0424@1|root,COG0424@2|Bacteria,2GNI0@201174|Actinobacteria,4DD3P@85008|Micromonosporales	201174|Actinobacteria	D	Maf-like protein	maf	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf,NUDIX
TLS2_k127_6013464_17	1464048.JNZS01000007_gene4603	1.467e-11	74.0	2BECQ@1|root,3283U@2|Bacteria,2HDVH@201174|Actinobacteria,4DKUV@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6013464_13	391037.Sare_0800	3.835e-53	193.0	COG1595@1|root,COG1595@2|Bacteria,2GKDD@201174|Actinobacteria,4DCE2@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6013464_20	1464048.JNZS01000007_gene4603	0.000541	51.0	2BECQ@1|root,3283U@2|Bacteria,2HDVH@201174|Actinobacteria,4DKUV@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6013464_19	543632.JOJL01000007_gene5334	0.0005288	51.0	COG3266@1|root,COG3266@2|Bacteria,2IKR0@201174|Actinobacteria,4DE2I@85008|Micromonosporales	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Gram_pos_anchor
TLS2_k127_6013464_8	1463936.JOJI01000007_gene3825	9.806e-82	283.0	2DBXI@1|root,2ZBQ3@2|Bacteria,2GJN1@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50B
TLS2_k127_6013464_15	994479.GL877879_gene5402	3.758e-40	165.0	2CMJR@1|root,32SF0@2|Bacteria,2GW0K@201174|Actinobacteria,4EB52@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6013464_9	1150864.MILUP08_40933	2.038e-71	245.0	COG4636@1|root,COG4636@2|Bacteria,2IQYX@201174|Actinobacteria,4DDDC@85008|Micromonosporales	201174|Actinobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS2_k127_6013464_1	263358.VAB18032_08940	3.105e-295	911.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4DBGE@85008|Micromonosporales	201174|Actinobacteria	I	Carboxyl transferase domain	pccB	GO:0003674,GO:0003824,GO:0003989,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009317,GO:0009987,GO:0015977,GO:0016020,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0030312,GO:0032787,GO:0032991,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:1901575,GO:1902494	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_6013464_11	1869.MB27_40505	2.729e-63	224.0	COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria,4DA2U@85008|Micromonosporales	201174|Actinobacteria	H	Biotin protein ligase C terminal domain	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
TLS2_k127_6024271_13	263358.VAB18032_01900	4.787e-124	402.0	COG0588@1|root,COG0588@2|Bacteria,2GK8F@201174|Actinobacteria,4DA06@85008|Micromonosporales	201174|Actinobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
TLS2_k127_6024271_15	35754.JNYJ01000008_gene3232	1.189e-100	344.0	COG1020@1|root,COG1020@2|Bacteria,2GSRJ@201174|Actinobacteria,4DI0J@85008|Micromonosporales	201174|Actinobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	Condensation
TLS2_k127_6024271_2	1121946.AUAX01000001_gene2261	8.438e-206	655.0	COG1132@1|root,COG1132@2|Bacteria,2GJTA@201174|Actinobacteria,4DBSJ@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_6024271_22	446462.Amir_2936	1.655e-55	205.0	COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,2H1NS@201174|Actinobacteria,4EDPY@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,HTH_31,NB-ARC,TPR_10,TPR_12,TPR_7,Trans_reg_C
TLS2_k127_6024271_3	351607.Acel_1604	3.118e-196	634.0	COG1505@1|root,COG1505@2|Bacteria,2IRXB@201174|Actinobacteria,4ERQG@85013|Frankiales	201174|Actinobacteria	E	peptidase S9A, prolyl oligopeptidase domain protein beta-propeller	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_6024271_1	436229.JOEH01000015_gene5995	9.278e-230	742.0	COG0515@1|root,COG0515@2|Bacteria,2GMRN@201174|Actinobacteria,2NG5A@228398|Streptacidiphilus	201174|Actinobacteria	KLT	Lanthionine synthetase C-like protein	-	-	-	-	-	-	-	-	-	-	-	-	LANC_like,Pkinase
TLS2_k127_6024271_19	219305.MCAG_02239	2.852e-77	267.0	COG0704@1|root,COG0704@2|Bacteria,2GKAD@201174|Actinobacteria,4DAT4@85008|Micromonosporales	201174|Actinobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0016020,GO:0019220,GO:0019222,GO:0022611,GO:0031323,GO:0031324,GO:0032502,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042221,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044444,GO:0044464,GO:0045936,GO:0046677,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:0071944,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TLS2_k127_6024271_7	33876.JNXY01000042_gene3818	4.73e-147	486.0	COG5002@1|root,COG5002@2|Bacteria,2GJY7@201174|Actinobacteria,4DB1E@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	senX3	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K07768	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
TLS2_k127_6024271_11	391037.Sare_0404	4.131e-126	406.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4DA4P@85008|Micromonosporales	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	regX3	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_6024271_9	35754.JNYJ01000014_gene4852	3.527e-140	452.0	COG4977@1|root,COG4977@2|Bacteria,2GIRA@201174|Actinobacteria,4DBBM@85008|Micromonosporales	201174|Actinobacteria	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
TLS2_k127_6024271_10	644283.Micau_5670	2.264e-132	426.0	28IRH@1|root,2Z8QX@2|Bacteria,2GJW6@201174|Actinobacteria,4D9CG@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6024271_12	644283.Micau_5669	4.003e-124	406.0	COG0248@1|root,COG0248@2|Bacteria,2GMME@201174|Actinobacteria,4D9XD@85008|Micromonosporales	201174|Actinobacteria	FP	Ppx/GppA phosphatase family	ppx1	GO:0003674,GO:0003824,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
TLS2_k127_6024271_14	134676.ACPL_7876	3.172e-117	389.0	COG1082@1|root,COG1082@2|Bacteria,2GJ6E@201174|Actinobacteria,4D9YH@85008|Micromonosporales	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_6024271_20	1464048.JNZS01000005_gene5413	5.429e-77	265.0	COG5516@1|root,COG5516@2|Bacteria,2GJZN@201174|Actinobacteria,4D9ZQ@85008|Micromonosporales	201174|Actinobacteria	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
TLS2_k127_6024271_8	263358.VAB18032_01850	1.245e-142	458.0	COG0506@1|root,COG0506@2|Bacteria,2GJTK@201174|Actinobacteria,4DB1R@85008|Micromonosporales	201174|Actinobacteria	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
TLS2_k127_6024271_16	263358.VAB18032_06650	2.32e-99	329.0	COG0778@1|root,COG0778@2|Bacteria,2GW57@201174|Actinobacteria,4DBUU@85008|Micromonosporales	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_6024271_23	219305.MCAG_03297	6.325e-46	168.0	COG5450@1|root,32SQA@2|Bacteria,2IKJX@201174|Actinobacteria,4DEBH@85008|Micromonosporales	201174|Actinobacteria	K	Transcription regulator of the Arc MetJ class	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6024271_18	263358.VAB18032_01540	2.718e-80	279.0	COG3883@1|root,COG3883@2|Bacteria,2I43R@201174|Actinobacteria,4DMIZ@85008|Micromonosporales	201174|Actinobacteria	S	PFAM NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6024271_17	1246995.AFR_04030	9.96e-89	299.0	COG0569@1|root,COG0569@2|Bacteria,2IA09@201174|Actinobacteria,4DCSC@85008|Micromonosporales	201174|Actinobacteria	P	TrkA-C domain	ktrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS2_k127_6024271_6	1246995.AFR_04035	7.566e-153	495.0	COG0168@1|root,COG0168@2|Bacteria,2GKKS@201174|Actinobacteria,4D8QD@85008|Micromonosporales	201174|Actinobacteria	P	Cation transport protein	ktrB	-	-	-	-	-	-	-	-	-	-	-	TrkH
TLS2_k127_6024271_24	1246995.AFR_04075	3.511e-38	147.0	COG1937@1|root,COG1937@2|Bacteria,2IQAC@201174|Actinobacteria,4DF1H@85008|Micromonosporales	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
TLS2_k127_6024271_25	33876.JNXY01000022_gene4596	1.122e-27	113.0	COG2608@1|root,COG2608@2|Bacteria,2GQK5@201174|Actinobacteria,4DFRB@85008|Micromonosporales	201174|Actinobacteria	P	PFAM Heavy metal transport detoxification protein	-	-	-	-	-	-	-	-	-	-	-	-	HMA
TLS2_k127_6024271_0	246196.MSMEI_4886	1.44e-281	883.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,232VV@1762|Mycobacteriaceae	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS2_k127_6024271_5	269800.Tfu_1633	9.76e-187	600.0	COG0747@1|root,COG0747@2|Bacteria,2GJ9N@201174|Actinobacteria,4EMIY@85012|Streptosporangiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_6024271_21	35754.JNYJ01000007_gene2866	9.38e-57	203.0	COG3860@1|root,COG3860@2|Bacteria,2IQEK@201174|Actinobacteria,4DE9G@85008|Micromonosporales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2087)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087,HTH_20
TLS2_k127_6024271_4	1122138.AQUZ01000010_gene5113	9.792e-195	629.0	COG1505@1|root,COG1505@2|Bacteria,2IRXB@201174|Actinobacteria,4DNMT@85009|Propionibacteriales	201174|Actinobacteria	E	prolyl oligopeptidase	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_6096298_13	1463861.JNXE01000023_gene4564	4.836e-14	73.0	COG0451@1|root,COG0451@2|Bacteria,2GJYY@201174|Actinobacteria	201174|Actinobacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_6096298_4	1464048.JNZS01000046_gene706	2.545e-123	430.0	COG0714@1|root,COG2197@1|root,COG0714@2|Bacteria,COG2197@2|Bacteria,2IC7E@201174|Actinobacteria,4DA6M@85008|Micromonosporales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_6096298_9	1120950.KB892775_gene1190	9.546e-36	148.0	COG3187@1|root,COG3187@2|Bacteria,2I9ND@201174|Actinobacteria,4DUY5@85009|Propionibacteriales	201174|Actinobacteria	O	META domain	hslJ	-	-	ko:K03668	-	-	-	-	ko00000	-	-	-	META
TLS2_k127_6096298_12	882083.SacmaDRAFT_5467	3.122e-23	109.0	COG2375@1|root,COG2375@2|Bacteria,2GK5X@201174|Actinobacteria,4EAXG@85010|Pseudonocardiales	201174|Actinobacteria	P	Siderophore-interacting protein	sidE	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_9,SIP
TLS2_k127_6096298_7	58344.JOEL01000010_gene5784	7.189e-42	169.0	COG0640@1|root,COG0640@2|Bacteria,2GTPG@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_6096298_5	1121272.KB903289_gene4150	1.121e-92	309.0	COG0572@1|root,COG0572@2|Bacteria,2GMCP@201174|Actinobacteria,4D8TG@85008|Micromonosporales	201174|Actinobacteria	F	uridine kinase	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
TLS2_k127_6096298_6	533240.CRC_03379	2.084e-78	277.0	COG4122@1|root,COG4122@2|Bacteria,1GITK@1117|Cyanobacteria,1HPPH@1161|Nostocales	1117|Cyanobacteria	V	Macrocin-O-methyltransferase (TylF)	-	-	-	ko:K05303	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_24,TylF
TLS2_k127_6096298_1	644283.Micau_3028	2.457e-216	674.0	COG4447@1|root,COG4447@2|Bacteria,2GM8J@201174|Actinobacteria,4D9DS@85008|Micromonosporales	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
TLS2_k127_6096298_8	35754.JNYJ01000040_gene1508	6.363e-41	153.0	COG1977@1|root,COG1977@2|Bacteria,2IQJJ@201174|Actinobacteria,4DEW0@85008|Micromonosporales	201174|Actinobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
TLS2_k127_6096298_10	1449976.KALB_6548	7.512e-33	131.0	COG1162@1|root,COG1162@2|Bacteria,2GU32@201174|Actinobacteria,4EC9I@85010|Pseudonocardiales	201174|Actinobacteria	S	RNHCP domain	-	-	-	-	-	-	-	-	-	-	-	-	RNHCP
TLS2_k127_6096298_3	263358.VAB18032_01310	3.703e-124	405.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4DATY@85008|Micromonosporales	201174|Actinobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS2_k127_6096298_2	219305.MCAG_02136	2.625e-152	499.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4D93Y@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN2	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_6096298_0	219305.MCAG_02137	2.917e-217	687.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4DB40@85008|Micromonosporales	201174|Actinobacteria	C	proton-translocating NADH-quinone oxidoreductase, chain M	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_6096298_11	33876.JNXY01000022_gene4562	3.151e-28	115.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4D9JY@85008|Micromonosporales	201174|Actinobacteria	CP	NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL2	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TLS2_k127_6145735_7	219305.MCAG_02391	6.624e-131	422.0	COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria,4DA92@85008|Micromonosporales	201174|Actinobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
TLS2_k127_6145735_19	35754.JNYJ01000036_gene3717	3.224e-39	162.0	2C7PW@1|root,34A2X@2|Bacteria,2ISVP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6145735_2	512565.AMIS_77620	3.924e-186	587.0	COG1623@1|root,COG1623@2|Bacteria,2GJ41@201174|Actinobacteria,4D9EZ@85008|Micromonosporales	201174|Actinobacteria	L	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process	disA	-	2.7.7.85	ko:K07067	-	-	-	-	ko00000,ko01000	-	-	-	DisA-linker,DisA_N,HHH,HHH_2
TLS2_k127_6145735_23	1246995.AFR_41315	7.098e-10	67.0	COG2847@1|root,COG2847@2|Bacteria,2GT33@201174|Actinobacteria,4DFNB@85008|Micromonosporales	201174|Actinobacteria	S	Copper chaperone PCu(A)C	-	-	-	-	-	-	-	-	-	-	-	-	PCuAC
TLS2_k127_6145735_14	1150864.MILUP08_46687	3.598e-89	301.0	COG0382@1|root,COG0382@2|Bacteria,2GJT3@201174|Actinobacteria,4DB5A@85008|Micromonosporales	201174|Actinobacteria	H	UbiA prenyltransferase family	ubiA	-	-	-	-	-	-	-	-	-	-	-	UbiA
TLS2_k127_6145735_12	1464048.JNZS01000002_gene491	1.289e-100	333.0	COG2227@1|root,COG2227@2|Bacteria,2ID71@201174|Actinobacteria,4D9P6@85008|Micromonosporales	201174|Actinobacteria	H	Methyltransferase domain	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
TLS2_k127_6145735_3	649831.L083_7842	3.353e-185	586.0	COG1960@1|root,COG1960@2|Bacteria,2H7DI@201174|Actinobacteria,4DC2X@85008|Micromonosporales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase type 2	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_6145735_6	1246995.AFR_41295	5.887e-146	469.0	COG3424@1|root,COG3424@2|Bacteria,2GV0U@201174|Actinobacteria,4DAQJ@85008|Micromonosporales	201174|Actinobacteria	Q	synthase	-	-	-	ko:K16167	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
TLS2_k127_6145735_21	543632.JOJL01000081_gene3159	1.229e-28	125.0	28RPX@1|root,2ZE2I@2|Bacteria,2IR1T@201174|Actinobacteria,4DEP5@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6145735_13	1121946.AUAX01000056_gene3241	2.739e-92	304.0	COG1329@1|root,COG1329@2|Bacteria,2GKSU@201174|Actinobacteria,4DAVJ@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator, CarD family	carD	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
TLS2_k127_6145735_17	649831.L083_7837	4.723e-67	237.0	COG1211@1|root,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,4DBAJ@85008|Micromonosporales	201174|Actinobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
TLS2_k127_6145735_16	644283.Micau_5833	1.123e-72	247.0	COG0245@1|root,COG0245@2|Bacteria,2II8H@201174|Actinobacteria,4DDC4@85008|Micromonosporales	201174|Actinobacteria	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008685,GO:0009058,GO:0009987,GO:0016114,GO:0016829,GO:0016849,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0051483,GO:0071704,GO:1901576	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3581c	YgbB
TLS2_k127_6145735_0	1121272.KB903263_gene589	2.962e-225	702.0	COG3508@1|root,COG3508@2|Bacteria,2GKZV@201174|Actinobacteria,4DA7H@85008|Micromonosporales	201174|Actinobacteria	Q	homogentisate 12-dioxygenase	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
TLS2_k127_6145735_11	219305.MCAG_02381	3.015e-102	340.0	COG0124@1|root,COG0124@2|Bacteria,2GJXW@201174|Actinobacteria,4D8MZ@85008|Micromonosporales	201174|Actinobacteria	J	histidyl-tRNA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6145735_4	263358.VAB18032_02580	1.455e-177	563.0	COG0179@1|root,COG0179@2|Bacteria,2GNGC@201174|Actinobacteria,4D8QR@85008|Micromonosporales	201174|Actinobacteria	Q	Fumarylacetoacetase	fahA	-	3.7.1.2	ko:K01555	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FAA_hydrolase,FAA_hydrolase_N
TLS2_k127_6145735_18	369723.Strop_4086	3.616e-61	235.0	COG0791@1|root,COG3266@1|root,COG0791@2|Bacteria,COG3266@2|Bacteria,2HEI4@201174|Actinobacteria,4D9RS@85008|Micromonosporales	201174|Actinobacteria	M	NLP P60 protein	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
TLS2_k127_6145735_1	649831.L083_0397	1.516e-222	693.0	COG1060@1|root,COG1060@2|Bacteria,2GTIY@201174|Actinobacteria,4D8UV@85008|Micromonosporales	201174|Actinobacteria	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
TLS2_k127_6145735_20	1136417.AZWE01000062_gene1443	1.265e-29	124.0	28UAC@1|root,2ZGFU@2|Bacteria,2GYXV@201174|Actinobacteria,4DF89@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6145735_22	1121946.AUAX01000006_gene3570	2.286e-19	94.0	2EHXC@1|root,33BNY@2|Bacteria,2GR8V@201174|Actinobacteria,4DFXB@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF4229)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4229
TLS2_k127_6145735_10	1121272.KB903250_gene3231	1.383e-109	362.0	COG1349@1|root,COG1349@2|Bacteria,2GJK9@201174|Actinobacteria,4D9T8@85008|Micromonosporales	201174|Actinobacteria	K	DeoR C terminal sensor domain	glpR	-	-	ko:K02081,ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
TLS2_k127_6145735_9	644283.Micau_0367	6.257e-114	382.0	COG1120@1|root,COG1120@2|Bacteria,2IA4F@201174|Actinobacteria,4DA8F@85008|Micromonosporales	201174|Actinobacteria	HP	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
TLS2_k127_6145735_5	391037.Sare_4500	9.991e-147	474.0	COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria,4D9B0@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
TLS2_k127_6145735_15	1869.MB27_05075	8.97e-79	276.0	COG0614@1|root,COG0614@2|Bacteria,2I2MI@201174|Actinobacteria,4D8H9@85008|Micromonosporales	201174|Actinobacteria	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	yvrC	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS2_k127_6145735_8	1121272.KB903250_gene3230	9.406e-131	425.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,4DAX5@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6145735_24	644283.Micau_1237	5.622e-05	48.0	COG1277@1|root,COG1277@2|Bacteria,2GNQV@201174|Actinobacteria,4DCVW@85008|Micromonosporales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS2_k127_6178949_30	263358.VAB18032_12755	2.839e-43	162.0	2DJKR@1|root,32UDA@2|Bacteria,2IQH2@201174|Actinobacteria,4DFAZ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178949_25	1121272.KB903255_gene5725	8.448e-56	214.0	COG0229@1|root,COG0229@2|Bacteria,2IHV0@201174|Actinobacteria,4DDB8@85008|Micromonosporales	201174|Actinobacteria	O	Peptide-methionine (R)-S-oxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
TLS2_k127_6178949_14	356851.JOAN01000008_gene3030	6.611e-173	560.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4D8RM@85008|Micromonosporales	201174|Actinobacteria	L	DNA primase, small subunit	ligD	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_primase_S
TLS2_k127_6178949_1	219305.MCAG_04478	0.0	1067.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4D8HA@85008|Micromonosporales	201174|Actinobacteria	HI	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
TLS2_k127_6178949_44	586413.CCDL010000001_gene1354	2.99e-08	60.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,4HABC@91061|Bacilli,23IN9@182709|Oceanobacillus	91061|Bacilli	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.264,1.1.1.303,1.1.1.4	ko:K00004,ko:K00098	ko00650,map00650	-	R02855,R02946,R05684,R10504	RC00089,RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_6178949_24	266117.Rxyl_2045	1.488e-72	249.0	COG0693@1|root,COG0693@2|Bacteria,2GMMW@201174|Actinobacteria,4CPWN@84995|Rubrobacteria	84995|Rubrobacteria	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
TLS2_k127_6178949_11	67373.JOBF01000007_gene2299	2.173e-179	572.0	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria	201174|Actinobacteria	C	NADH dehydrogenase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_6178949_7	263358.VAB18032_14315	1.281e-220	695.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria,4DAI6@85008|Micromonosporales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS2_k127_6178949_27	55952.BU52_01030	5.227e-48	186.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_6178949_37	273068.TTE2230	1.817e-23	108.0	COG2406@1|root,COG2406@2|Bacteria,1VD9N@1239|Firmicutes,24Q5S@186801|Clostridia,42HYP@68295|Thermoanaerobacterales	186801|Clostridia	S	Ferritin-like domain	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TLS2_k127_6178949_13	1121946.AUAX01000019_gene7788	1.963e-178	567.0	COG2230@1|root,COG2230@2|Bacteria,2GJ94@201174|Actinobacteria,4DA2F@85008|Micromonosporales	201174|Actinobacteria	M	Mycolic acid cyclopropane synthetase	cfa	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS2_k127_6178949_8	345341.KUTG_07041	5.14e-198	627.0	COG0277@1|root,COG0277@2|Bacteria,2GKQR@201174|Actinobacteria,4DYBE@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
TLS2_k127_6178949_29	926560.KE387023_gene1920	2.337e-45	190.0	COG2374@1|root,COG2374@2|Bacteria,1WM95@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	U	PFAM Endonuclease Exonuclease phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Exo_endo_phos,LTD
TLS2_k127_6178949_5	1121926.AXWO01000013_gene2076	2.456e-255	826.0	COG2374@1|root,COG2374@2|Bacteria,2HZ1P@201174|Actinobacteria,4EZBW@85014|Glycomycetales	201174|Actinobacteria	S	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178949_3	882082.SaccyDRAFT_2420	7.263e-264	830.0	COG0339@1|root,COG0339@2|Bacteria,2GM2Z@201174|Actinobacteria,4E24H@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Peptidase family M3	dcp	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
TLS2_k127_6178949_40	1246448.ANAZ01000048_gene3286	1.26e-12	80.0	COG2314@1|root,COG2314@2|Bacteria,2ICDQ@201174|Actinobacteria	201174|Actinobacteria	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
TLS2_k127_6178949_43	1121272.KB903272_gene492	2.613e-10	73.0	2AUYC@1|root,31KMU@2|Bacteria,2IJE4@201174|Actinobacteria,4DJ8T@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	ko:K19720	ko04611,ko04926,ko04933,ko04974,ko05146,map04611,map04926,map04933,map04974,map05146	-	-	-	ko00000,ko00001,ko00536	-	-	-	HIRAN
TLS2_k127_6178949_23	391037.Sare_0795	6.034e-74	274.0	COG1404@1|root,COG1404@2|Bacteria,2GIRE@201174|Actinobacteria,4DCN6@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	mycP	-	-	ko:K14743	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
TLS2_k127_6178949_28	471852.Tcur_2270	2.837e-47	175.0	COG5502@1|root,COG5502@2|Bacteria,2IM7U@201174|Actinobacteria,4EPEU@85012|Streptosporangiales	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2267)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2267
TLS2_k127_6178949_20	1150864.MILUP08_43852	1.577e-87	302.0	COG1819@1|root,COG1819@2|Bacteria,2GKKY@201174|Actinobacteria,4DECW@85008|Micromonosporales	201174|Actinobacteria	CG	Protein of unknown function (DUF1205)	-	-	-	ko:K21259	ko01059,ko01130,map01059,map01130	M00833	R11417	RC00005,RC00049	ko00000,ko00001,ko00002,ko01000	-	GT1	-	DUF1205,Glyco_tran_28_C,UDPGT
TLS2_k127_6178949_17	446470.Snas_4448	2.469e-139	463.0	COG0557@1|root,COG0557@2|Bacteria,2HYZ1@201174|Actinobacteria,4EXV9@85014|Glycomycetales	201174|Actinobacteria	K	RNB	-	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB
TLS2_k127_6178949_41	211114.JOEF01000022_gene5666	3.316e-12	74.0	COG0346@1|root,COG0346@2|Bacteria,2IHZH@201174|Actinobacteria,4E4CC@85010|Pseudonocardiales	201174|Actinobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	gloA	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_6178949_21	749414.SBI_09390	1.474e-80	274.0	COG3828@1|root,COG3828@2|Bacteria,2I9N0@201174|Actinobacteria	201174|Actinobacteria	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
TLS2_k127_6178949_31	1150864.MILUP08_45402	1.626e-42	161.0	COG1366@1|root,COG1366@2|Bacteria,2IJJS@201174|Actinobacteria,4DDFI@85008|Micromonosporales	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
TLS2_k127_6178949_19	263358.VAB18032_13575	1.802e-115	379.0	COG1230@1|root,COG1230@2|Bacteria,2GMRZ@201174|Actinobacteria,4DBPK@85008|Micromonosporales	201174|Actinobacteria	P	cation diffusion facilitator family transporter	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
TLS2_k127_6178949_2	263358.VAB18032_27826	3.689e-283	887.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,4DB7E@85008|Micromonosporales	201174|Actinobacteria	L	DNA helicase	helD	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD-helicase,UvrD_C_2
TLS2_k127_6178949_26	219305.MCAG_01409	1.475e-49	179.0	2F9XC@1|root,3426S@2|Bacteria,2IKZQ@201174|Actinobacteria,4DE8I@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178949_22	1150864.MILUP08_45389	1.723e-74	258.0	299E4@1|root,2ZWGX@2|Bacteria,2GM90@201174|Actinobacteria,4DBBZ@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3145)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3145
TLS2_k127_6178949_6	391037.Sare_3624	3.872e-246	771.0	COG4799@1|root,COG4799@2|Bacteria,2I16G@201174|Actinobacteria,4DC6P@85008|Micromonosporales	201174|Actinobacteria	I	propionyl-CoA carboxylase	accD6	GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009317,GO:0009987,GO:0016042,GO:0016053,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019367,GO:0019752,GO:0030312,GO:0030497,GO:0032787,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:0072330,GO:1901575,GO:1901576,GO:1902494	2.1.3.15,6.4.1.2,6.4.1.3	ko:K18472	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04386	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_6178949_15	35754.JNYJ01000030_gene7550	1.117e-172	551.0	COG0304@1|root,COG0304@2|Bacteria,2GIY4@201174|Actinobacteria,4DA1A@85008|Micromonosporales	201174|Actinobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS2_k127_6178949_32	263358.VAB18032_27791	3.639e-34	139.0	COG0236@1|root,COG0236@2|Bacteria,2IQ43@201174|Actinobacteria,4DEZ2@85008|Micromonosporales	201174|Actinobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006643,GO:0006644,GO:0006664,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009245,GO:0009247,GO:0009259,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0019637,GO:0019693,GO:0019752,GO:0019842,GO:0030312,GO:0031177,GO:0032787,GO:0033218,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046483,GO:0046493,GO:0048037,GO:0051186,GO:0051192,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072341,GO:0072521,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901360,GO:1901564,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS2_k127_6178949_16	263358.VAB18032_27786	4.816e-158	504.0	COG0332@1|root,COG0332@2|Bacteria,2GJP8@201174|Actinobacteria,4DBQ5@85008|Micromonosporales	201174|Actinobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
TLS2_k127_6178949_12	391037.Sare_3620	1.059e-178	569.0	COG0331@1|root,COG0511@1|root,COG0331@2|Bacteria,COG0511@2|Bacteria,2GME0@201174|Actinobacteria,4D91Q@85008|Micromonosporales	201174|Actinobacteria	I	Acyl transferase domain	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005835,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
TLS2_k127_6178949_10	1150864.MILUP08_45382	5.961e-183	579.0	COG2508@1|root,COG2508@2|Bacteria,2GN0S@201174|Actinobacteria,4DBPA@85008|Micromonosporales	201174|Actinobacteria	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
TLS2_k127_6178949_36	1121272.KB903253_gene6848	1.221e-23	113.0	2ASES@1|root,31HUI@2|Bacteria,2IH78@201174|Actinobacteria,4DCQ1@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178949_35	33876.JNXY01000018_gene7843	2.68e-24	110.0	COG2372@1|root,COG2372@2|Bacteria,2HZ01@201174|Actinobacteria,4DFT1@85008|Micromonosporales	201174|Actinobacteria	S	CopC domain	-	-	-	ko:K07156	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC
TLS2_k127_6178949_4	219305.MCAG_01391	1.31e-257	799.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,4D8K8@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS2_k127_6178949_38	1094980.Mpsy_2565	1.578e-19	100.0	arCOG11924@1|root,arCOG11924@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178949_9	1463856.JOHY01000027_gene3714	1.139e-192	634.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator, SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,HTH_31,NB-ARC,TPR_12,TPR_7,Trans_reg_C
TLS2_k127_6178949_0	1386089.N865_11870	0.0	1543.0	COG1372@1|root,COG3209@1|root,COG1372@2|Bacteria,COG3209@2|Bacteria,2GK1D@201174|Actinobacteria,4FIX8@85021|Intrasporangiaceae	201174|Actinobacteria	M	Salmonella virulence plasmid 65kDa B protein	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,RHS_repeat,SpvB
TLS2_k127_6178949_34	711393.AYRX01000095_gene3549	8.252e-26	126.0	COG3291@1|root,COG3291@2|Bacteria,2GJR2@201174|Actinobacteria	201174|Actinobacteria	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9
TLS2_k127_6178949_39	935866.JAER01000006_gene3367	3.756e-13	85.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4DP00@85009|Propionibacteriales	201174|Actinobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Laminin_G_3,Malectin,PKD
TLS2_k127_6178949_18	479432.Sros_7437	2.092e-135	482.0	COG3209@1|root,COG3534@1|root,COG3209@2|Bacteria,COG3534@2|Bacteria,2I35N@201174|Actinobacteria,4EIAW@85012|Streptosporangiales	201174|Actinobacteria	M	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
TLS2_k127_6178984_14	1136417.AZWE01000026_gene1756	6.473e-213	669.0	COG0439@1|root,COG0439@2|Bacteria,2I2S0@201174|Actinobacteria,4D8KW@85008|Micromonosporales	201174|Actinobacteria	I	Biotin carboxylase	pycA	-	6.3.4.14,6.4.1.2,6.4.1.3	ko:K01961,ko:K01965	ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00373,M00376,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TLS2_k127_6178984_60	33876.JNXY01000025_gene5275	5.378e-83	299.0	COG1309@1|root,COG1309@2|Bacteria,2GIUW@201174|Actinobacteria,4DB6S@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_6178984_81	1122182.KB903813_gene2084	7.36e-47	179.0	2DMG6@1|root,32RB5@2|Bacteria,2GMQI@201174|Actinobacteria	201174|Actinobacteria	S	MDMPI C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
TLS2_k127_6178984_47	1150864.MILUP08_40028	8.272e-110	363.0	COG2755@1|root,COG2755@2|Bacteria,2GNBP@201174|Actinobacteria,4D9MB@85008|Micromonosporales	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS2_k127_6178984_4	263358.VAB18032_04655	1.104e-271	846.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,4DAC0@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
TLS2_k127_6178984_66	1120949.KB903331_gene3385	1.242e-68	239.0	COG2606@1|root,COG2606@2|Bacteria,2GKUX@201174|Actinobacteria,4DD9P@85008|Micromonosporales	201174|Actinobacteria	S	YbaK prolyl-tRNA synthetase associated	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
TLS2_k127_6178984_89	1386089.N865_18765	5.196e-29	124.0	2E7YB@1|root,332CR@2|Bacteria,2IRTP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
TLS2_k127_6178984_12	1122611.KB904029_gene5236	1.595e-215	718.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4ENKK@85012|Streptosporangiales	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8
TLS2_k127_6178984_49	1121272.KB903283_gene5287	5.146e-108	358.0	COG3616@1|root,COG3616@2|Bacteria,2GK0N@201174|Actinobacteria,4DGUA@85008|Micromonosporales	201174|Actinobacteria	E	Alanine racemase, N-terminal domain	-	-	4.3.1.27	ko:K20757	-	-	-	-	ko00000,ko01000	-	-	-	Ala_racemase_N,D-ser_dehydrat
TLS2_k127_6178984_43	1121272.KB903283_gene5288	3.231e-121	411.0	COG0477@1|root,COG2814@2|Bacteria,2GJPT@201174|Actinobacteria,4DBDI@85008|Micromonosporales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS2_k127_6178984_52	1121272.KB903283_gene5289	1.126e-96	344.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_6178984_75	1150399.AQYK01000001_gene1784	5.162e-52	200.0	COG0477@1|root,COG2814@2|Bacteria,2GKHG@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS2_k127_6178984_98	106370.Francci3_1091	2.1e-10	63.0	COG3654@1|root,COG3654@2|Bacteria,2IR34@201174|Actinobacteria,4ET91@85013|Frankiales	201174|Actinobacteria	S	Fic/DOC family	doc	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
TLS2_k127_6178984_101	1089544.KB912942_gene6390	0.0005817	44.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria,4E5GJ@85010|Pseudonocardiales	201174|Actinobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_6178984_95	644283.Micau_0012	2.488e-14	74.0	2C94U@1|root,2ZNDI@2|Bacteria,2GWSD@201174|Actinobacteria,4DGDN@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178984_76	219305.MCAG_02887	1.295e-51	198.0	COG3266@1|root,COG3266@2|Bacteria,2GKZP@201174|Actinobacteria,4D9UB@85008|Micromonosporales	201174|Actinobacteria	S	Transmembrane domain of unknown function (DUF3566)	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF3566
TLS2_k127_6178984_0	1464048.JNZS01000009_gene5811	0.0	2014.0	COG0188@1|root,COG1372@1|root,COG0188@2|Bacteria,COG1372@2|Bacteria,2GJ2Q@201174|Actinobacteria	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV,Intein_splicing,LAGLIDADG_3
TLS2_k127_6178984_2	1121946.AUAX01000006_gene3347	0.0	1149.0	COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,4DAYP@85008|Micromonosporales	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS2_k127_6178984_58	33876.JNXY01000025_gene5259	6.482e-84	285.0	2AMMM@1|root,31CHP@2|Bacteria,2HUQ8@201174|Actinobacteria,4DAAP@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178984_67	1136417.AZWE01000026_gene1778	1.467e-67	237.0	COG5512@1|root,COG5512@2|Bacteria,2GNQ4@201174|Actinobacteria,4DD2D@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
TLS2_k127_6178984_25	1464048.JNZS01000009_gene5805	1.132e-164	525.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4DBQ4@85008|Micromonosporales	201174|Actinobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
TLS2_k127_6178984_36	1136417.AZWE01000026_gene1780	6.04e-137	441.0	COG1023@1|root,COG1023@2|Bacteria,2I2DH@201174|Actinobacteria,4DAZ4@85008|Micromonosporales	201174|Actinobacteria	G	6-phosphogluconate dehydrogenase	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
TLS2_k127_6178984_21	33876.JNXY01000025_gene5255	8.25e-174	552.0	COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria,4DB6V@85008|Micromonosporales	201174|Actinobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
TLS2_k127_6178984_15	390989.JOEG01000004_gene3868	4.036e-208	664.0	COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria,4DAG5@85008|Micromonosporales	201174|Actinobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C
TLS2_k127_6178984_94	35754.JNYJ01000013_gene1167	1.57e-16	79.0	COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria,4DGJJ@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
TLS2_k127_6178984_88	1120936.KB907218_gene3458	2.368e-29	123.0	COG0594@1|root,COG0594@2|Bacteria,2GR42@201174|Actinobacteria,4EKWP@85012|Streptosporangiales	201174|Actinobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	GO:0008150,GO:0040007	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
TLS2_k127_6178984_86	391037.Sare_5109	2.704e-34	134.0	COG0759@1|root,COG0759@2|Bacteria,2GQZG@201174|Actinobacteria,4DG1Z@85008|Micromonosporales	201174|Actinobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	ytjA	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
TLS2_k127_6178984_48	391037.Sare_5108	2.27e-109	367.0	COG0706@1|root,COG0706@2|Bacteria,2GJBU@201174|Actinobacteria,4D8H4@85008|Micromonosporales	201174|Actinobacteria	U	60 kDa inner membrane insertion protein	yidC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
TLS2_k127_6178984_64	1136417.AZWE01000026_gene1786	1.221e-76	261.0	COG1847@1|root,COG1847@2|Bacteria,2GPZK@201174|Actinobacteria,4DA0U@85008|Micromonosporales	201174|Actinobacteria	S	single-stranded nucleic acid binding R3H	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	KH_4,R3H
TLS2_k127_6178984_59	390989.JOEG01000004_gene3864	1.832e-83	284.0	COG0357@1|root,COG0357@2|Bacteria,2GM9Z@201174|Actinobacteria,4DCVP@85008|Micromonosporales	201174|Actinobacteria	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
TLS2_k127_6178984_32	644283.Micau_6293	2.959e-156	515.0	COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4D8H7@85008|Micromonosporales	201174|Actinobacteria	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS2_k127_6178984_35	356851.JOAN01000004_gene1062	3.243e-143	460.0	COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,4D8Z7@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the ParB family	parB	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
TLS2_k127_6178984_65	1120950.KB892745_gene2892	1.177e-70	246.0	COG4758@1|root,COG4758@2|Bacteria,2I8FE@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF1707)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1707,DUF2154
TLS2_k127_6178984_50	644283.Micau_6290	4.109e-105	352.0	COG0537@1|root,COG0537@2|Bacteria,2HNIX@201174|Actinobacteria,4DAR0@85008|Micromonosporales	201174|Actinobacteria	FG	adenosine 5'-monophosphoramidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178984_33	1150864.MILUP08_30213	3.582e-155	494.0	COG1181@1|root,COG1181@2|Bacteria,2GRWM@201174|Actinobacteria,4DA6S@85008|Micromonosporales	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TLS2_k127_6178984_10	263358.VAB18032_04415	2.434e-223	700.0	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria,4DB4A@85008|Micromonosporales	201174|Actinobacteria	EK	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	avtA	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
TLS2_k127_6178984_5	649831.L083_5660	6.879e-270	862.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,4DAKK@85008|Micromonosporales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_6178984_68	644283.Micau_6287	1.681e-67	235.0	COG3153@1|root,COG3153@2|Bacteria,2GNNB@201174|Actinobacteria,4D8XA@85008|Micromonosporales	201174|Actinobacteria	S	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_6178984_20	1464048.JNZS01000009_gene5790	4.407e-175	556.0	COG0860@1|root,COG3409@1|root,COG0860@2|Bacteria,COG3409@2|Bacteria,2GPA9@201174|Actinobacteria,4D9CS@85008|Micromonosporales	201174|Actinobacteria	M	Ami_3	cwlM	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,PG_binding_1
TLS2_k127_6178984_78	391037.Sare_5098	2.286e-50	181.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4DE4S@85008|Micromonosporales	201174|Actinobacteria	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS2_k127_6178984_30	1121946.AUAX01000006_gene3371	1.305e-158	506.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,4D9Y1@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913	Pyr_redox_2
TLS2_k127_6178984_90	644283.Micau_6283	3.052e-26	124.0	COG5662@1|root,COG5662@2|Bacteria,2IHCS@201174|Actinobacteria,4DD8W@85008|Micromonosporales	201174|Actinobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178984_57	1464048.JNZS01000009_gene5786	6.657e-85	290.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4DD37@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigM	GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6178984_31	543632.JOJL01000029_gene3670	3.885e-157	512.0	COG0515@1|root,COG0515@2|Bacteria,2GM4A@201174|Actinobacteria,4DA7V@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS2_k127_6178984_16	369723.Strop_1632	3.972e-203	654.0	COG0367@1|root,COG0367@2|Bacteria,2GJIM@201174|Actinobacteria,4DIMP@85008|Micromonosporales	201174|Actinobacteria	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
TLS2_k127_6178984_19	263358.VAB18032_04375	3.861e-181	602.0	COG0728@1|root,COG0728@2|Bacteria,2GKN0@201174|Actinobacteria,4DBCV@85008|Micromonosporales	201174|Actinobacteria	S	virulence factor	mviN	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TLS2_k127_6178984_7	219305.MCAG_02858	1.684e-260	807.0	COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria,4D8N9@85008|Micromonosporales	201174|Actinobacteria	J	Polynucleotide adenylyltransferase metal dependent phosphohydrolase	pcnA	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
TLS2_k127_6178984_11	644283.Micau_6277	2.625e-216	681.0	COG2268@1|root,COG2268@2|Bacteria,2GK9I@201174|Actinobacteria,4D8CU@85008|Micromonosporales	201174|Actinobacteria	S	Flotillin	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
TLS2_k127_6178984_83	356851.JOAN01000004_gene1077	4.754e-41	159.0	2EBIV@1|root,335JA@2|Bacteria,2IHZS@201174|Actinobacteria,4DE5V@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
TLS2_k127_6178984_82	1121946.AUAX01000006_gene3380	1.05e-44	168.0	2EDBE@1|root,3377Q@2|Bacteria,2IB65@201174|Actinobacteria,4DG96@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178984_87	1121946.AUAX01000006_gene3381	3.018e-33	136.0	2EDBE@1|root,3377Q@2|Bacteria,2IB65@201174|Actinobacteria,4DG96@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178984_17	391037.Sare_5081	7.963e-200	629.0	COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4DAG6@85008|Micromonosporales	201174|Actinobacteria	I	Myo-inositol-1-phosphate synthase	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
TLS2_k127_6178984_51	1150864.MILUP08_30197	2.185e-97	322.0	COG1695@1|root,COG1695@2|Bacteria,2GMJM@201174|Actinobacteria,4D8M9@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
TLS2_k127_6178984_73	1464048.JNZS01000009_gene5775	3.349e-55	198.0	2CQNK@1|root,32SMG@2|Bacteria,2IIJ7@201174|Actinobacteria,4DDFW@85008|Micromonosporales	201174|Actinobacteria	S	Family of unknown function (DUF5318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5318
TLS2_k127_6178984_34	1121946.AUAX01000006_gene3387	1.333e-154	521.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4D8PM@85008|Micromonosporales	201174|Actinobacteria	M	glycosyl transferase family	pbp1A	GO:0001666,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0008144,GO:0008150,GO:0008658,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0033554,GO:0036094,GO:0036293,GO:0036294,GO:0042221,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0050896,GO:0051716,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0097159,GO:1901363,GO:1901681	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
TLS2_k127_6178984_69	1122182.KB903815_gene1560	7.831e-67	235.0	COG0500@1|root,COG0500@2|Bacteria,2GNZU@201174|Actinobacteria,4DAPJ@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS2_k127_6178984_24	1150864.MILUP08_30194	1.327e-165	537.0	COG5650@1|root,COG5650@2|Bacteria,2GJYA@201174|Actinobacteria,4D8M3@85008|Micromonosporales	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
TLS2_k127_6178984_9	263358.VAB18032_04325	2.38e-233	743.0	COG1971@1|root,COG1971@2|Bacteria,2GUWT@201174|Actinobacteria,4DBW7@85008|Micromonosporales	201174|Actinobacteria	P	Probably functions as a manganese efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178984_39	219305.MCAG_02846	2.197e-128	415.0	COG0648@1|root,COG0648@2|Bacteria,2GJJQ@201174|Actinobacteria,4DAX4@85008|Micromonosporales	201174|Actinobacteria	L	AP endonuclease family 2	nfo	GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
TLS2_k127_6178984_99	1122182.KB903815_gene1427	3.395e-09	68.0	2B0UC@1|root,31T6W@2|Bacteria,2GSXS@201174|Actinobacteria,4DFP9@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178984_80	1246995.AFR_42830	6.256e-49	175.0	COG0360@1|root,COG0360@2|Bacteria,2IQHD@201174|Actinobacteria,4DEAX@85008|Micromonosporales	201174|Actinobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
TLS2_k127_6178984_63	1136417.AZWE01000031_gene4804	4.096e-77	261.0	COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,4DCAH@85008|Micromonosporales	201174|Actinobacteria	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_6178984_84	33876.JNXY01000037_gene8062	2.676e-36	143.0	COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,4DF7Q@85008|Micromonosporales	201174|Actinobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
TLS2_k127_6178984_70	543632.JOJL01000029_gene3654	3.353e-63	224.0	COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria,4DCPI@85008|Micromonosporales	201174|Actinobacteria	J	Binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
TLS2_k127_6178984_96	219305.MCAG_02841	8.827e-14	81.0	COG3170@1|root,COG3170@2|Bacteria,2GT0Z@201174|Actinobacteria,4DFUJ@85008|Micromonosporales	201174|Actinobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178984_8	356851.JOAN01000004_gene1093	1.029e-242	758.0	COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4D8N4@85008|Micromonosporales	201174|Actinobacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
TLS2_k127_6178984_53	1313172.YM304_02680	3.006e-96	323.0	COG0258@1|root,COG0258@2|Bacteria,2H2A3@201174|Actinobacteria	201174|Actinobacteria	L	5'-3' exonuclease, C-terminal SAM fold	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
TLS2_k127_6178984_38	208444.JNYY01000009_gene3333	5.683e-129	431.0	COG1641@1|root,COG1641@2|Bacteria,2I8J1@201174|Actinobacteria,4E10F@85010|Pseudonocardiales	201174|Actinobacteria	S	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
TLS2_k127_6178984_55	208444.JNYY01000009_gene3334	5.767e-92	312.0	COG1691@1|root,COG1691@2|Bacteria,2IAKU@201174|Actinobacteria,4E2XT@85010|Pseudonocardiales	201174|Actinobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
TLS2_k127_6178984_62	1120950.KB892775_gene1193	1.719e-77	268.0	COG0546@1|root,COG1606@1|root,COG0546@2|Bacteria,COG1606@2|Bacteria,2GPA1@201174|Actinobacteria,4DP0G@85009|Propionibacteriales	201174|Actinobacteria	S	PFAM ExsB family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,HAD,HAD_2,Hydrolase_like,NAD_synthase,QueC
TLS2_k127_6178984_45	390989.JOEG01000012_gene3462	1.318e-116	383.0	COG0204@1|root,COG0204@2|Bacteria,2IAXZ@201174|Actinobacteria	201174|Actinobacteria	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_6178984_6	1123322.KB904634_gene2305	1.378e-267	831.0	COG3875@1|root,COG3875@2|Bacteria,2IAM4@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
TLS2_k127_6178984_26	390989.JOEG01000012_gene3460	2.84e-164	525.0	COG1063@1|root,COG1063@2|Bacteria,2IBQC@201174|Actinobacteria,4DJKR@85008|Micromonosporales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_6178984_3	390989.JOEG01000012_gene3459	6.058e-304	949.0	COG0451@1|root,COG0560@1|root,COG0451@2|Bacteria,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria	201174|Actinobacteria	E	HAD-superfamily subfamily IB hydrolase, TIGR01490	-	-	-	-	-	-	-	-	-	-	-	-	HAD,NAD_binding_4,Sterile
TLS2_k127_6178984_79	543632.JOJL01000029_gene3596	3.091e-49	181.0	2F7ME@1|root,3401X@2|Bacteria,2IG97@201174|Actinobacteria,4DDJK@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178984_18	263358.VAB18032_03885	2.664e-183	579.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4DBM8@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the thiolase family	fadA6_2	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_6178984_91	1136417.AZWE01000053_gene3978	1.118e-22	103.0	2ESQF@1|root,33K8W@2|Bacteria,2ISUG@201174|Actinobacteria,4DF6Z@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_6
TLS2_k127_6178984_54	644283.Micau_6169	7.098e-96	322.0	COG0705@1|root,COG0705@2|Bacteria,2GJYG@201174|Actinobacteria,4DAHC@85008|Micromonosporales	201174|Actinobacteria	S	Rhomboid family	yggP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid,zf-B_box
TLS2_k127_6178984_61	263358.VAB18032_03900	1.214e-81	289.0	COG0652@1|root,COG0652@2|Bacteria,2IFUE@201174|Actinobacteria,4DCYD@85008|Micromonosporales	201174|Actinobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030312,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:0140096,GO:1901564	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
TLS2_k127_6178984_92	1121272.KB903261_gene6289	1.021e-21	101.0	29W87@1|root,30HTH@2|Bacteria,2GU01@201174|Actinobacteria,4DFS7@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178984_102	710111.FraQA3DRAFT_3189	0.0009967	46.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,4ESJH@85013|Frankiales	201174|Actinobacteria	GM	NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
TLS2_k127_6178984_29	644283.Micau_6173	3.981e-163	520.0	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria,4DAUR@85008|Micromonosporales	201174|Actinobacteria	EK	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	-	-	-	ko:K03710,ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000,ko03000	-	-	-	Aminotran_1_2,GntR
TLS2_k127_6178984_77	1121946.AUAX01000006_gene3267	1.173e-50	184.0	COG2905@1|root,COG2905@2|Bacteria,2HUC9@201174|Actinobacteria,4DE72@85008|Micromonosporales	201174|Actinobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_6178984_72	33876.JNXY01000005_gene8813	1.201e-61	220.0	COG0590@1|root,COG0590@2|Bacteria,2IM3Z@201174|Actinobacteria,4DDC8@85008|Micromonosporales	201174|Actinobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.1,3.5.4.33	ko:K01485,ko:K11991	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922,R10223	RC00074,RC00477,RC00514,RC00809	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
TLS2_k127_6178984_71	1121272.KB903261_gene6034	4.046e-63	222.0	2E70D@1|root,331J9@2|Bacteria,2GYEC@201174|Actinobacteria,4DDBK@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178984_85	1464048.JNZS01000002_gene628	1.882e-35	138.0	29134@1|root,2ZNQN@2|Bacteria,2IQXY@201174|Actinobacteria,4DFHD@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178984_44	1121946.AUAX01000003_gene1838	3.23e-117	387.0	COG0287@1|root,COG0287@2|Bacteria,2GKB4@201174|Actinobacteria,4D8ZX@85008|Micromonosporales	201174|Actinobacteria	E	Prephenate dehydrogenase	tyrA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.3.1.12	ko:K00210,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
TLS2_k127_6178984_40	1120949.KB903319_gene9830	9.709e-126	413.0	COG0182@1|root,COG0182@2|Bacteria,2GJJA@201174|Actinobacteria,4DCAG@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the eIF-2B alpha beta delta subunits family	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
TLS2_k127_6178984_22	1150864.MILUP08_46839	6.398e-170	539.0	COG1387@1|root,COG1387@2|Bacteria,2GMFH@201174|Actinobacteria,4DB7K@85008|Micromonosporales	201174|Actinobacteria	E	Histidinol phosphatase and related hydrolases of the PHP family	polX	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_8,PHP
TLS2_k127_6178984_46	263358.VAB18032_03390	7.16e-111	387.0	COG0697@1|root,COG0697@2|Bacteria,2GK49@201174|Actinobacteria,4DA8P@85008|Micromonosporales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_6178984_41	1464048.JNZS01000009_gene5735	3.934e-124	404.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria,4D8MQ@85008|Micromonosporales	201174|Actinobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
TLS2_k127_6178984_56	1150864.MILUP08_30162	1.458e-85	297.0	2AR9G@1|root,31GJC@2|Bacteria,2GN9V@201174|Actinobacteria,4DAW5@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4192)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4192
TLS2_k127_6178984_74	1246995.AFR_42655	5.084e-55	197.0	COG0454@1|root,COG0456@2|Bacteria,2INMX@201174|Actinobacteria,4DE01@85008|Micromonosporales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_6178984_42	644283.Micau_6240	5.451e-123	422.0	COG3001@1|root,COG3001@2|Bacteria,2GW7W@201174|Actinobacteria,4DA68@85008|Micromonosporales	201174|Actinobacteria	G	Fructosamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
TLS2_k127_6178984_93	391037.Sare_5047	3.504e-21	104.0	COG1977@1|root,COG1977@2|Bacteria,2IQIT@201174|Actinobacteria,4DFX3@85008|Micromonosporales	201174|Actinobacteria	H	ThiS family	moaD2	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS2_k127_6178984_28	33876.JNXY01000037_gene8035	3.962e-163	522.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4DA6Q@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
TLS2_k127_6178984_37	391037.Sare_5048	1.28e-131	439.0	COG1408@1|root,COG1408@2|Bacteria,2GMST@201174|Actinobacteria,4D8YP@85008|Micromonosporales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
TLS2_k127_6178984_1	1150864.MILUP08_30167	0.0	1424.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,2I12T@201174|Actinobacteria,4DAIS@85008|Micromonosporales	201174|Actinobacteria	L	UvrD/REP helicase N-terminal domain	pcrA	-	-	-	-	-	-	-	-	-	-	-	UvrD-helicase,UvrD_C
TLS2_k127_6178984_100	134676.ACPL_8326	2.146e-05	55.0	29W86@1|root,30HTG@2|Bacteria,2IMET@201174|Actinobacteria,4DE45@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6178984_13	263358.VAB18032_04210	1.133e-213	668.0	COG1672@1|root,COG1672@2|Bacteria,2GWBV@201174|Actinobacteria,4DB9A@85008|Micromonosporales	201174|Actinobacteria	C	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
TLS2_k127_6178984_27	219305.MCAG_02831	3.272e-164	531.0	COG3170@1|root,COG3170@2|Bacteria,2I40K@201174|Actinobacteria,4D9D3@85008|Micromonosporales	201174|Actinobacteria	NU	Glycosyltransferase family 87	-	-	-	ko:K13671	-	-	-	-	ko00000,ko01000,ko01003	-	GT87	-	GT87
TLS2_k127_6178984_23	1298880.AUEV01000004_gene1946	1.669e-167	533.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,2GIYE@201174|Actinobacteria	201174|Actinobacteria	EQ	PFAM Hydantoinase oxoprolinase	oplA	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0266c	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
TLS2_k127_6181501_8	1449976.KALB_75	1.069e-19	97.0	COG4683@1|root,COG4683@2|Bacteria,2IFY3@201174|Actinobacteria,4EB36@85010|Pseudonocardiales	201174|Actinobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
TLS2_k127_6181501_7	33876.JNXY01000005_gene8728	3.767e-23	101.0	COG3620@1|root,COG3620@2|Bacteria,2IKRP@201174|Actinobacteria,4DJGF@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
TLS2_k127_6181501_4	1075090.GOAMR_76_00560	4.262e-39	149.0	COG2402@1|root,COG2402@2|Bacteria,2IRQ5@201174|Actinobacteria,4GGRX@85026|Gordoniaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_6181501_10	1122182.KB903813_gene2707	8.165e-17	85.0	COG2253@1|root,COG2253@2|Bacteria,2I3Y9@201174|Actinobacteria,4DMF9@85008|Micromonosporales	201174|Actinobacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
TLS2_k127_6181501_5	1246448.ANAZ01000008_gene2571	3.086e-33	136.0	COG0454@1|root,COG0456@2|Bacteria,2INFZ@201174|Actinobacteria,4EQNR@85012|Streptosporangiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_6181501_9	645465.ACUR01000038_gene1086	1.164e-17	89.0	COG2318@1|root,COG2318@2|Bacteria,2HUJD@201174|Actinobacteria	201174|Actinobacteria	K	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
TLS2_k127_6181501_3	1121272.KB903290_gene4638	3.621e-48	179.0	2B3UX@1|root,31WIT@2|Bacteria,2GXDG@201174|Actinobacteria,4DGPB@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6181501_2	649831.L083_7295	1.508e-81	278.0	COG0500@1|root,COG2226@2|Bacteria,2GP9N@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_6181501_1	1303692.SFUL_2049	9.978e-90	298.0	COG3576@1|root,COG3576@2|Bacteria,2HBPN@201174|Actinobacteria	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_6181501_0	1150864.MILUP08_46816	8.769e-111	366.0	COG0500@1|root,COG0500@2|Bacteria,2I3UR@201174|Actinobacteria,4DBU3@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_6225397_0	1464048.JNZS01000008_gene6068	3.29e-59	212.0	COG3764@1|root,COG3764@2|Bacteria,2IR30@201174|Actinobacteria,4DCMF@85008|Micromonosporales	201174|Actinobacteria	M	peptidase C60 sortase A and B	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
TLS2_k127_6225397_1	33876.JNXY01000031_gene2932	1.339e-52	196.0	COG1651@1|root,COG1651@2|Bacteria,2GKH8@201174|Actinobacteria,4DDAG@85008|Micromonosporales	201174|Actinobacteria	O	Dsba oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
TLS2_k127_6225397_2	1150864.MILUP08_41286	1.279e-50	186.0	COG2259@1|root,COG2259@2|Bacteria,2IQEY@201174|Actinobacteria,4DE57@85008|Micromonosporales	201174|Actinobacteria	S	Methylamine utilisation protein MauE	-	-	-	-	-	-	-	-	-	-	-	-	DoxX,MauE
TLS2_k127_6225397_5	1123023.JIAI01000002_gene5864	1.422e-07	54.0	2DPGP@1|root,331ZU@2|Bacteria,2GR4I@201174|Actinobacteria,4EEAP@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6225397_4	390989.JOEG01000013_gene2532	4.565e-14	78.0	2DPGP@1|root,331ZU@2|Bacteria,2GR4I@201174|Actinobacteria,4DFVW@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6225397_3	882083.SacmaDRAFT_0136	1.512e-41	156.0	2DPEX@1|root,331T0@2|Bacteria,2IR24@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_6232536_8	1464048.JNZS01000034_gene2611	5.253e-206	665.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4D8KT@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_6232536_17	1150864.MILUP08_45168	5.022e-121	401.0	COG0648@1|root,COG0648@2|Bacteria,2GJJQ@201174|Actinobacteria,4D9Q4@85008|Micromonosporales	201174|Actinobacteria	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
TLS2_k127_6232536_46	33876.JNXY01000008_gene8484	6.101e-14	76.0	2EGDD@1|root,33A58@2|Bacteria,2GR3X@201174|Actinobacteria,4DEMF@85008|Micromonosporales	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
TLS2_k127_6232536_44	1435356.Y013_02965	6.731e-24	112.0	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,4FUNV@85025|Nocardiaceae	201174|Actinobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	GO:0006950,GO:0008150,GO:0050896,GO:0051409	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
TLS2_k127_6232536_14	710111.FraQA3DRAFT_0025	4.663e-142	464.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4ES9B@85013|Frankiales	201174|Actinobacteria	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_6232536_19	65497.JODV01000007_gene647	1.08e-119	393.0	COG1253@1|root,COG1253@2|Bacteria,2GJ8X@201174|Actinobacteria,4DZW2@85010|Pseudonocardiales	201174|Actinobacteria	S	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
TLS2_k127_6232536_2	263358.VAB18032_08475	5.962e-262	820.0	COG0488@1|root,COG0488@2|Bacteria,2GJ5M@201174|Actinobacteria,4DA5P@85008|Micromonosporales	201174|Actinobacteria	S	ATPase components of ABC transporters with duplicated ATPase domains	yjjK	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
TLS2_k127_6232536_31	1068980.ARVW01000001_gene588	1.461e-88	305.0	COG0500@1|root,COG2226@2|Bacteria,2IP4P@201174|Actinobacteria,4E5RD@85010|Pseudonocardiales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_6232536_45	1122182.KB903839_gene1027	1.126e-17	84.0	COG1251@1|root,COG1251@2|Bacteria,2HZ55@201174|Actinobacteria,4DGNM@85008|Micromonosporales	201174|Actinobacteria	C	BFD-like [2Fe-2S] binding domain	-	-	-	ko:K02192	-	-	-	-	ko00000	-	-	-	Fer2_BFD
TLS2_k127_6232536_32	35754.JNYJ01000038_gene5056	2.21e-87	291.0	COG2193@1|root,COG2193@2|Bacteria,2GJEI@201174|Actinobacteria,4DAQG@85008|Micromonosporales	201174|Actinobacteria	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TLS2_k127_6232536_38	1121946.AUAX01000004_gene669	2.076e-53	193.0	COG4403@1|root,COG4403@2|Bacteria,2GKVV@201174|Actinobacteria,4DCMN@85008|Micromonosporales	201174|Actinobacteria	V	Domain of unknown function (DUF4135)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4135,LANC_like
TLS2_k127_6232536_39	1116232.AHBF01000018_gene3786	3.783e-53	192.0	COG0262@1|root,COG0262@2|Bacteria,2IM1S@201174|Actinobacteria	201174|Actinobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	GO:0000166,GO:0003674,GO:0003824,GO:0004146,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070401,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2763c	DHFR_1
TLS2_k127_6232536_12	219305.MCAG_01247	1.572e-157	505.0	COG2008@1|root,COG2008@2|Bacteria,2GMNV@201174|Actinobacteria,4DAY8@85008|Micromonosporales	201174|Actinobacteria	E	Threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_6232536_3	219305.MCAG_01248	5.974e-262	821.0	COG3200@1|root,COG3200@2|Bacteria,2GJBX@201174|Actinobacteria,4D8Q3@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the class-II DAHP synthase family	aroH	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
TLS2_k127_6232536_29	35754.JNYJ01000003_gene6414	1.33e-90	302.0	COG1435@1|root,COG1435@2|Bacteria,2GP1W@201174|Actinobacteria,4D9CP@85008|Micromonosporales	201174|Actinobacteria	F	thymidine kinase	tdk	GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
TLS2_k127_6232536_34	356851.JOAN01000010_gene4627	1.232e-72	247.0	COG0386@1|root,COG0386@2|Bacteria,2IFJH@201174|Actinobacteria,4DDAW@85008|Micromonosporales	201174|Actinobacteria	O	Belongs to the glutathione peroxidase family	btuE	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
TLS2_k127_6232536_15	1246995.AFR_09630	6.226e-129	417.0	COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria,4D8KX@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
TLS2_k127_6232536_9	644283.Micau_4533	9.219e-188	589.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4DA29@85008|Micromonosporales	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
TLS2_k127_6232536_30	1150864.MILUP08_45183	1.658e-90	301.0	2CPKU@1|root,32SJD@2|Bacteria,2I3ZF@201174|Actinobacteria,4DC49@85008|Micromonosporales	201174|Actinobacteria	L	Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA	-	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040007,GO:0042802	-	-	-	-	-	-	-	-	-	-	DUF5051
TLS2_k127_6232536_22	1121272.KB903252_gene1149	1.47e-112	371.0	COG3342@1|root,COG3342@2|Bacteria,2HWBG@201174|Actinobacteria,4DA1Q@85008|Micromonosporales	201174|Actinobacteria	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
TLS2_k127_6232536_21	219305.MCAG_01257	1.033e-112	369.0	COG0664@1|root,COG0664@2|Bacteria,2I7B7@201174|Actinobacteria,4DAN8@85008|Micromonosporales	201174|Actinobacteria	K	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_6232536_48	1150864.MILUP08_45185	1.067e-08	64.0	2BEEH@1|root,3285P@2|Bacteria,2HDXM@201174|Actinobacteria,4DKTK@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6232536_0	1150864.MILUP08_45186	0.0	1300.0	COG1040@1|root,COG2114@1|root,COG3899@1|root,COG1040@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,4DBEY@85008|Micromonosporales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
TLS2_k127_6232536_23	1464048.JNZS01000034_gene2629	3.08e-111	379.0	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria,4D8HE@85008|Micromonosporales	201174|Actinobacteria	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_6232536_37	219305.MCAG_01260	2.002e-60	226.0	2EN8E@1|root,33FW7@2|Bacteria,2HU51@201174|Actinobacteria,4DBCH@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6232536_25	219305.MCAG_01262	1.953e-109	360.0	COG2267@1|root,COG2267@2|Bacteria,2I8UI@201174|Actinobacteria,4DAZS@85008|Micromonosporales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
TLS2_k127_6232536_6	1136417.AZWE01000002_gene3560	1.405e-212	672.0	COG2072@1|root,COG2072@2|Bacteria,2GMDH@201174|Actinobacteria,4DANN@85008|Micromonosporales	201174|Actinobacteria	P	Flavin-binding monooxygenase-like	pedG	-	-	-	-	-	-	-	-	-	-	-	FMO-like
TLS2_k127_6232536_35	649831.L083_1919	6.849e-70	244.0	COG3568@1|root,COG3568@2|Bacteria,2GMRU@201174|Actinobacteria,4DCTZ@85008|Micromonosporales	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_6232536_18	33876.JNXY01000013_gene4052	1.894e-120	398.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,4D97U@85008|Micromonosporales	201174|Actinobacteria	GK	ROK family	glkA	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044464,GO:0046835,GO:0051156,GO:0071704,GO:1901135	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_6232536_47	356851.JOAN01000010_gene4607	8.524e-14	84.0	2DSQS@1|root,33H36@2|Bacteria,2IJ17@201174|Actinobacteria,4DDNY@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6232536_36	1246995.AFR_09545	1.038e-64	224.0	COG2867@1|root,COG2867@2|Bacteria,2IFH4@201174|Actinobacteria,4DDAU@85008|Micromonosporales	201174|Actinobacteria	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2
TLS2_k127_6232536_5	356851.JOAN01000010_gene4604	1.396e-225	713.0	COG4585@1|root,COG4585@2|Bacteria,2IAQN@201174|Actinobacteria,4DB2Q@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_3,HATPase_c,HisKA_3
TLS2_k127_6232536_20	33876.JNXY01000013_gene4047	1.908e-117	381.0	COG2197@1|root,COG2197@2|Bacteria,2IBDE@201174|Actinobacteria,4D9GH@85008|Micromonosporales	201174|Actinobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_6232536_42	1122182.KB903833_gene5415	6.934e-45	168.0	COG0537@1|root,COG0537@2|Bacteria,2IFHR@201174|Actinobacteria,4DEA9@85008|Micromonosporales	201174|Actinobacteria	FG	adenosine 5'-monophosphoramidase activity	-	-	-	-	-	-	-	-	-	-	-	-	HIT
TLS2_k127_6232536_26	1150864.MILUP08_45200	8.428e-107	353.0	COG2890@1|root,COG2890@2|Bacteria,2GITA@201174|Actinobacteria,4DBD3@85008|Micromonosporales	201174|Actinobacteria	J	S-adenosyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_19
TLS2_k127_6232536_7	33876.JNXY01000013_gene4043	8.18e-211	675.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4D9XV@85008|Micromonosporales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4,PAS_9
TLS2_k127_6232536_10	219305.MCAG_01273	4.776e-179	568.0	COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,4DB93@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyl transferases group 1	pimB	-	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_6232536_11	1150864.MILUP08_45210	2.153e-165	532.0	COG3688@1|root,COG3688@2|Bacteria,2GR19@201174|Actinobacteria,4DBBR@85008|Micromonosporales	201174|Actinobacteria	S	YacP-like NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN_YacP
TLS2_k127_6232536_40	391037.Sare_3520	1.649e-50	197.0	COG0494@1|root,COG0494@2|Bacteria,2I2TW@201174|Actinobacteria,4DMCV@85008|Micromonosporales	201174|Actinobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_6232536_28	219305.MCAG_01281	4.434e-97	329.0	COG1208@1|root,COG1208@2|Bacteria,2IEN7@201174|Actinobacteria,4D963@85008|Micromonosporales	201174|Actinobacteria	JM	Nucleotidyl transferase	-	-	2.7.7.13,2.7.7.99	ko:K00966,ko:K00992	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885,R11025	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_3,NTP_transferase
TLS2_k127_6232536_1	219305.MCAG_03124	0.0	1031.0	COG1770@1|root,COG1770@2|Bacteria,2GNA9@201174|Actinobacteria,4DAD5@85008|Micromonosporales	201174|Actinobacteria	E	Oligopeptidase b	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_6232536_4	1120950.KB892720_gene1878	1.399e-230	747.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GMMM@201174|Actinobacteria,4DPKW@85009|Propionibacteriales	201174|Actinobacteria	EU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_6232536_27	1464048.JNZS01000020_gene2176	7.404e-98	327.0	COG4757@1|root,COG4757@2|Bacteria,2ICF8@201174|Actinobacteria,4DBDQ@85008|Micromonosporales	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
TLS2_k127_6232536_13	219305.MCAG_01290	1.178e-155	499.0	COG0547@1|root,COG0547@2|Bacteria,2GM4G@201174|Actinobacteria,4D92J@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TLS2_k127_6232536_41	391037.Sare_3529	4.146e-49	178.0	COG0784@1|root,COG0784@2|Bacteria,2II71@201174|Actinobacteria,4DERB@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_6232536_16	263358.VAB18032_27231	4.129e-125	407.0	COG3336@1|root,COG3336@2|Bacteria,2GKIR@201174|Actinobacteria,4D95Z@85008|Micromonosporales	201174|Actinobacteria	S	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	ko:K02351,ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	Caa3_CtaG
TLS2_k127_6232536_33	369723.Strop_3295	3.147e-82	300.0	COG1845@1|root,COG1845@2|Bacteria,2GKK8@201174|Actinobacteria,4DBBV@85008|Micromonosporales	201174|Actinobacteria	C	oxidase, subunit	ctaE	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
TLS2_k127_6232536_24	391037.Sare_3526	1.516e-110	363.0	COG2010@1|root,COG2010@2|Bacteria,2GKUB@201174|Actinobacteria,4DATX@85008|Micromonosporales	201174|Actinobacteria	C	cytochrome C	qcrC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03889	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_CBB3
TLS2_k127_6232536_43	1120949.KB903302_gene6566	3.805e-43	164.0	COG0723@1|root,COG0723@2|Bacteria,2GIX6@201174|Actinobacteria,4D8VB@85008|Micromonosporales	201174|Actinobacteria	C	Rieske [2Fe-2S] domain	qcrA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03890	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Rieske
TLS2_k127_6244912_0	263358.VAB18032_26180	0.0	1208.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4D8NT@85008|Micromonosporales	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
TLS2_k127_6244912_1	1120950.KB892771_gene1328	9.951e-272	852.0	COG3408@1|root,COG3408@2|Bacteria,2GIUI@201174|Actinobacteria,4DNXN@85009|Propionibacteriales	201174|Actinobacteria	G	N-terminal domain of (some) glycogen debranching enzymes	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
TLS2_k127_6244912_3	1121272.KB903252_gene1063	3.548e-71	263.0	2ETNT@1|root,33M6H@2|Bacteria,2I9E8@201174|Actinobacteria,4DCC8@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6244912_2	1150864.MILUP08_45001	3.735e-124	410.0	COG0237@1|root,COG2320@1|root,COG0237@2|Bacteria,COG2320@2|Bacteria,2GN96@201174|Actinobacteria,4DCAZ@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE,GrpB
TLS2_k127_6254992_14	263358.VAB18032_20535	1.539e-77	263.0	COG1136@1|root,COG1136@2|Bacteria,2GIV7@201174|Actinobacteria,4DC4Q@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_6254992_11	1464048.JNZS01000021_gene2759	2.015e-105	347.0	COG1136@1|root,COG1136@2|Bacteria,2GJQV@201174|Actinobacteria,4D9QK@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6254992_8	33876.JNXY01000001_gene5690	1.319e-149	514.0	COG0577@1|root,COG0577@2|Bacteria,2H997@201174|Actinobacteria,4DBGI@85008|Micromonosporales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
TLS2_k127_6254992_13	134676.ACPL_2575	1.147e-83	309.0	COG0577@1|root,COG0577@2|Bacteria,2GNEX@201174|Actinobacteria,4DCK8@85008|Micromonosporales	201174|Actinobacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
TLS2_k127_6254992_17	644283.Micau_0224	2.158e-35	138.0	COG2452@1|root,COG2452@2|Bacteria,2GQJ9@201174|Actinobacteria,4DEVR@85008|Micromonosporales	201174|Actinobacteria	L	Helix-turn-helix domain	bldC	-	-	-	-	-	-	-	-	-	-	-	HTH_17
TLS2_k127_6254992_9	649831.L083_0145	5.907e-128	413.0	2BPHM@1|root,32IA4@2|Bacteria,2GM2J@201174|Actinobacteria,4DAHJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6254992_5	369723.Strop_0159	1.975e-186	590.0	COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4DAEJ@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	vdh	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.4.1.23	ko:K00271	ko00280,ko01100,ko01110,ko01130,map00280,map01100,map01110,map01130	-	R01212,R01434	RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS2_k127_6254992_21	219305.MCAG_03047	5.451e-14	74.0	2EGRW@1|root,33AI2@2|Bacteria,2IQF3@201174|Actinobacteria,4DFQ7@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3073)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3073
TLS2_k127_6254992_6	1121946.AUAX01000006_gene3562	8.661e-170	540.0	COG0641@1|root,COG0641@2|Bacteria,2HU6E@201174|Actinobacteria,4DC1H@85008|Micromonosporales	201174|Actinobacteria	C	Radical SAM	aslB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Radical_SAM
TLS2_k127_6254992_4	33876.JNXY01000025_gene5390	3.161e-187	590.0	COG0150@1|root,COG0150@2|Bacteria,2GJNY@201174|Actinobacteria,4DASB@85008|Micromonosporales	201174|Actinobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016882,GO:0044424,GO:0044444,GO:0044464	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_6254992_2	1123024.AUII01000023_gene303	8.875e-226	714.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4DZFC@85010|Pseudonocardiales	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
TLS2_k127_6254992_16	219305.MCAG_03041	3.263e-43	162.0	COG3255@1|root,COG3255@2|Bacteria,2IQBF@201174|Actinobacteria,4DE93@85008|Micromonosporales	201174|Actinobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
TLS2_k127_6254992_20	1121926.AXWO01000020_gene2019	2.487e-19	104.0	2FCKB@1|root,344PM@2|Bacteria,2I63W@201174|Actinobacteria,4EYUS@85014|Glycomycetales	201174|Actinobacteria	S	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6254992_0	644283.Micau_0214	0.0	1154.0	COG0046@1|root,COG0046@2|Bacteria,2GKG6@201174|Actinobacteria,4DAZT@85008|Micromonosporales	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_6254992_10	134676.ACPL_232	5.989e-109	361.0	COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,4D9AB@85008|Micromonosporales	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
TLS2_k127_6254992_19	649831.L083_0132	5.966e-30	124.0	COG1828@1|root,COG1828@2|Bacteria,2GQV4@201174|Actinobacteria,4DESE@85008|Micromonosporales	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
TLS2_k127_6254992_15	1121946.AUAX01000006_gene3507	2.637e-52	191.0	COG2119@1|root,COG2119@2|Bacteria,2GNR0@201174|Actinobacteria,4D8J9@85008|Micromonosporales	201174|Actinobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
TLS2_k127_6254992_1	356851.JOAN01000026_gene1876	3.368e-230	723.0	COG0015@1|root,COG0015@2|Bacteria,2GKBR@201174|Actinobacteria,4DBUB@85008|Micromonosporales	201174|Actinobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
TLS2_k127_6254992_18	1476876.JOJO01000001_gene7717	1.048e-31	128.0	COG1672@1|root,COG1672@2|Bacteria,2GMAZ@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Archaeal ATPase	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	AAA_16,DUF234
TLS2_k127_6254992_3	1136417.AZWE01000070_gene1262	1.336e-211	663.0	COG0183@1|root,COG0183@2|Bacteria,2GJI8@201174|Actinobacteria,4D8FY@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the thiolase family	fadI	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_6254992_7	356851.JOAN01000026_gene1871	5.251e-167	536.0	COG1028@1|root,COG1028@2|Bacteria,2GJCZ@201174|Actinobacteria,4D91M@85008|Micromonosporales	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_6254992_12	1120949.KB903301_gene6353	4.168e-92	312.0	COG2030@1|root,COG2030@2|Bacteria,2GNQQ@201174|Actinobacteria,4DC1A@85008|Micromonosporales	201174|Actinobacteria	I	Maoc domain protein dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS2_k127_6264313_11	1137271.AZUM01000010_gene1735	1.526e-05	54.0	COG5180@1|root,COG5180@2|Bacteria,2GKJ7@201174|Actinobacteria,4E186@85010|Pseudonocardiales	201174|Actinobacteria	A	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	GPDPase_memb
TLS2_k127_6264313_3	1246995.AFR_04990	2.098e-137	444.0	COG1051@1|root,COG1051@2|Bacteria,2IBER@201174|Actinobacteria,4DAA2@85008|Micromonosporales	201174|Actinobacteria	F	Nudix hydrolase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS2_k127_6264313_6	263358.VAB18032_00655	6.269e-96	328.0	COG1051@1|root,COG1051@2|Bacteria,2IQZT@201174|Actinobacteria,4DACN@85008|Micromonosporales	201174|Actinobacteria	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_6264313_4	134676.ACPL_876	1.827e-105	351.0	COG1183@1|root,COG1183@2|Bacteria,2I3MV@201174|Actinobacteria,4DA88@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	GO:0003674,GO:0003824,GO:0003882,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_tran_2,CDP-OH_P_transf
TLS2_k127_6264313_1	219305.MCAG_01977	3.007e-170	547.0	COG0688@1|root,COG0688@2|Bacteria,2GMMF@201174|Actinobacteria,4D95G@85008|Micromonosporales	201174|Actinobacteria	I	phosphatidylserine decarboxylase	psd	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
TLS2_k127_6264313_10	219305.MCAG_01976	1.208e-09	68.0	29MCR@1|root,308AJ@2|Bacteria,2GU2S@201174|Actinobacteria,4DFWC@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6264313_7	219305.MCAG_01975	1.04e-69	254.0	COG1983@1|root,COG3266@1|root,COG1983@2|Bacteria,COG3266@2|Bacteria,2GIVS@201174|Actinobacteria,4DAQE@85008|Micromonosporales	201174|Actinobacteria	KT	PspC domain	pspC	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
TLS2_k127_6264313_2	219305.MCAG_01974	2.897e-141	460.0	COG4585@1|root,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4D8Z1@85008|Micromonosporales	201174|Actinobacteria	T	signal transduction histidine kinase	tcsS3	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,PspC
TLS2_k127_6264313_5	263358.VAB18032_00625	4.519e-102	343.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4D9AV@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	tcsR3	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_6264313_9	1121272.KB903250_gene2899	6.384e-30	121.0	COG1605@1|root,COG1605@2|Bacteria,2IQ8K@201174|Actinobacteria,4DEUF@85008|Micromonosporales	201174|Actinobacteria	E	chorismate mutase	csm	GO:0003674,GO:0003824,GO:0004106,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016866,GO:0019438,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.99.5	ko:K04093	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
TLS2_k127_6264313_0	644283.Micau_5402	0.0	1214.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4DB8T@85008|Micromonosporales	201174|Actinobacteria	L	ATP-dependent DNA helicase	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS2_k127_6264313_8	1121272.KB903250_gene2896	1.39e-52	198.0	COG0739@1|root,COG0739@2|Bacteria,2GU2Q@201174|Actinobacteria,4DCWB@85008|Micromonosporales	201174|Actinobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,Peptidase_M23
TLS2_k127_6302908_1	1120949.KB903298_gene5785	5.586e-90	304.0	COG1262@1|root,COG1262@2|Bacteria,2GK9Q@201174|Actinobacteria,4D9VE@85008|Micromonosporales	201174|Actinobacteria	C	Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine	egtB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0019439,GO:0019752,GO:0034641,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052708,GO:0052803,GO:0052805,GO:0055114,GO:0071704,GO:0097164,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	DinB_2,FGE-sulfatase
TLS2_k127_6302908_0	1464048.JNZS01000043_gene3560	1.575e-140	458.0	COG3572@1|root,COG3572@2|Bacteria,2GJPI@201174|Actinobacteria,4DBKG@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine	egtA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
TLS2_k127_6364700_20	356851.JOAN01000013_gene5701	1.497e-07	63.0	2DMAW@1|root,32EM1@2|Bacteria,2I9A0@201174|Actinobacteria,4D8YH@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6364700_9	263358.VAB18032_01435	1.252e-90	305.0	COG1309@1|root,COG1309@2|Bacteria,2GVM5@201174|Actinobacteria,4D9C7@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_6364700_15	298654.FraEuI1c_0748	1.335e-22	103.0	2E3M2@1|root,32YJA@2|Bacteria,2GQQW@201174|Actinobacteria,4ETF4@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3107)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3107
TLS2_k127_6364700_10	390989.JOEG01000019_gene5990	2.25e-79	271.0	COG1633@1|root,COG1633@2|Bacteria,2I2E1@201174|Actinobacteria,4DMKF@85008|Micromonosporales	201174|Actinobacteria	S	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like	-	-	-	-	-	-	-	-	-	-	-	-	MiaE_2
TLS2_k127_6364700_3	1074488.AGBX01000006_gene2128	2.132e-160	520.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4FCI3@85020|Dermabacteraceae	201174|Actinobacteria	L	helicase superfamily c-terminal domain	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
TLS2_k127_6364700_5	1463853.JOHW01000011_gene3493	4.571e-133	431.0	COG2220@1|root,COG2220@2|Bacteria,2GNXJ@201174|Actinobacteria	201174|Actinobacteria	S	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_6364700_2	644283.Micau_5590	1.56e-161	519.0	COG2813@1|root,COG2813@2|Bacteria,2GM2R@201174|Actinobacteria,4D997@85008|Micromonosporales	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_32
TLS2_k127_6364700_11	263358.VAB18032_14325	6.849e-49	178.0	COG3832@1|root,COG3832@2|Bacteria,2IKZ7@201174|Actinobacteria,4DDF5@85008|Micromonosporales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_6364700_17	326424.FRAAL6268	2.142e-15	88.0	2EA4S@1|root,3349P@2|Bacteria,2HTK9@201174|Actinobacteria,4ETD8@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6364700_14	479432.Sros_8031	3.115e-23	109.0	2DVB6@1|root,33V3R@2|Bacteria,2ISX6@201174|Actinobacteria,4EKBR@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6364700_19	318424.EU78_01600	6.635e-09	61.0	COG1302@1|root,COG1302@2|Bacteria,2GWZ9@201174|Actinobacteria,23BK5@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6364700_12	1463821.JOGR01000005_gene3003	2.217e-46	173.0	COG1302@1|root,COG1302@2|Bacteria,2IMA3@201174|Actinobacteria,4F02U@85014|Glycomycetales	201174|Actinobacteria	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
TLS2_k127_6364700_7	33876.JNXY01000025_gene5462	6.182e-106	349.0	COG0302@1|root,COG0302@2|Bacteria,2GP2P@201174|Actinobacteria,4DANE@85008|Micromonosporales	201174|Actinobacteria	H	GTP cyclohydrolase	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3609c	GTP_cyclohydroI
TLS2_k127_6364700_0	649831.L083_7888	0.0	1071.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4D8S3@85008|Micromonosporales	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TLS2_k127_6364700_8	219305.MCAG_02432	5.162e-94	310.0	COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,4D9UA@85008|Micromonosporales	201174|Actinobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	GO:0003674,GO:0003824,GO:0004422,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0052657,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS2_k127_6364700_1	1128421.JAGA01000003_gene3453	4.299e-198	632.0	COG0405@1|root,COG0405@2|Bacteria,2NP14@2323|unclassified Bacteria	2|Bacteria	E	Gamma-glutamyltranspeptidase	ggt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_6364700_13	1463903.JOIZ01000007_gene4059	9.092e-25	105.0	COG2026@1|root,COG2026@2|Bacteria,2IN19@201174|Actinobacteria	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
TLS2_k127_6364700_6	644283.Micau_5889	1.332e-112	376.0	COG0037@1|root,COG0037@2|Bacteria,2GJR4@201174|Actinobacteria,4DBS2@85008|Micromonosporales	201174|Actinobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	GO:0008150,GO:0040007	2.4.2.8,6.3.4.19	ko:K00760,ko:K04075	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,TilS
TLS2_k127_6364700_4	369723.Strop_4311	6.018e-157	505.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,4DAW7@85008|Micromonosporales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
TLS2_k127_6364700_16	1150864.MILUP08_46741	1.779e-18	87.0	COG2027@1|root,COG2027@2|Bacteria,2GJPH@201174|Actinobacteria,4DATD@85008|Micromonosporales	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
TLS2_k127_6375531_4	40571.JOEA01000030_gene5579	7.576e-183	609.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,4E16G@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_6375531_8	1122182.KB903813_gene2675	3.474e-98	334.0	COG1300@1|root,COG1300@2|Bacteria,2GJTG@201174|Actinobacteria,4D9ID@85008|Micromonosporales	201174|Actinobacteria	S	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
TLS2_k127_6375531_10	1121946.AUAX01000026_gene6289	8.284e-85	290.0	COG1714@1|root,COG1714@2|Bacteria,2H4MP@201174|Actinobacteria,4D8TD@85008|Micromonosporales	201174|Actinobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS2_k127_6375531_13	644283.Micau_1245	3.033e-37	145.0	2AYJ3@1|root,31QNW@2|Bacteria,2ISE1@201174|Actinobacteria,4DF6Q@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6375531_6	263358.VAB18032_10990	5.502e-125	406.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,4D8V8@85008|Micromonosporales	201174|Actinobacteria	I	enoyl-CoA hydratase	echA17	GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_6375531_1	1246995.AFR_37050	2.126e-266	829.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4DA3Q@85008|Micromonosporales	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	ilvG	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1820	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_6375531_0	1306406.ASHX01000002_gene4990	0.0	1114.0	COG2183@1|root,COG2183@2|Bacteria,2GKCI@201174|Actinobacteria	201174|Actinobacteria	K	accessory protein	yhgF	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
TLS2_k127_6375531_11	369723.Strop_3538	3.541e-59	207.0	COG2346@1|root,COG2346@2|Bacteria,2IKPF@201174|Actinobacteria,4DCRN@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial-like globin	glbO	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
TLS2_k127_6375531_5	391037.Sare_3912	1.15e-128	429.0	COG0477@1|root,COG2814@2|Bacteria,2HCHA@201174|Actinobacteria,4D8ZA@85008|Micromonosporales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_6375531_7	644283.Micau_4949	2.345e-105	351.0	COG0668@1|root,COG0668@2|Bacteria,2GMFK@201174|Actinobacteria,4D8RK@85008|Micromonosporales	201174|Actinobacteria	M	Mechanosensitive ion channel	mscS	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
TLS2_k127_6375531_9	1150864.MILUP08_45731	2.857e-91	305.0	COG1403@1|root,COG1403@2|Bacteria,2GN1W@201174|Actinobacteria,4D9I4@85008|Micromonosporales	201174|Actinobacteria	L	endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
TLS2_k127_6375531_12	391037.Sare_1719	2.948e-57	209.0	COG3764@1|root,COG3764@2|Bacteria,2IFPY@201174|Actinobacteria,4DCW1@85008|Micromonosporales	201174|Actinobacteria	M	peptidase C60 sortase A and B	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
TLS2_k127_6375531_14	543632.JOJL01000023_gene1770	1.864e-22	104.0	2CC99@1|root,301FA@2|Bacteria,2GQGR@201174|Actinobacteria,4DFTA@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6375531_2	644283.Micau_4943	6.322e-209	656.0	COG3844@1|root,COG3844@2|Bacteria,2GMJQ@201174|Actinobacteria,4DBYN@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
TLS2_k127_6375531_3	219305.MCAG_01610	3.087e-204	655.0	COG0654@1|root,COG0654@2|Bacteria,2GNR6@201174|Actinobacteria,4D9IQ@85008|Micromonosporales	201174|Actinobacteria	CH	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid	kmo	-	1.14.13.9	ko:K00486	ko00380,ko01100,map00380,map01100	M00038	R01960	RC00046	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
TLS2_k127_6375531_15	1464048.JNZS01000011_gene5003	7.837e-17	87.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4D919@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	amnC	-	1.2.1.32,1.2.1.85	ko:K10217	ko00362,ko00380,ko00622,ko01100,ko01120,ko01220,map00362,map00380,map00622,map01100,map01120,map01220	M00038,M00569	R02762,R03889,R05353	RC00218,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_6420861_1	1120950.KB892747_gene3715	0.0	1255.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,2GIYE@201174|Actinobacteria,4DNZP@85009|Propionibacteriales	201174|Actinobacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	oplA	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0266c	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
TLS2_k127_6420861_69	561175.KB894095_gene2568	4.329e-06	51.0	2DMWY@1|root,32U6G@2|Bacteria,2ISFN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6420861_49	1150864.MILUP08_30178	1.81e-67	234.0	COG0521@1|root,COG0521@2|Bacteria,2II28@201174|Actinobacteria,4DCNE@85008|Micromonosporales	201174|Actinobacteria	H	Molybdenum cofactor synthesis	mog	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoaE
TLS2_k127_6420861_44	649831.L083_8165	2.232e-73	250.0	COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,4DDCJ@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
TLS2_k127_6420861_51	1464048.JNZS01000009_gene5726	5.3e-67	243.0	291ZT@1|root,2ZPJ4@2|Bacteria,2GR7R@201174|Actinobacteria,4DD7Q@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF2587)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2587
TLS2_k127_6420861_36	644283.Micau_6230	2.451e-91	308.0	COG1506@1|root,COG1506@2|Bacteria,2I3Z4@201174|Actinobacteria,4DCIS@85008|Micromonosporales	201174|Actinobacteria	E	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Abhydrolase_6,Peptidase_S9
TLS2_k127_6420861_33	1464048.JNZS01000009_gene5728	2.687e-101	344.0	COG0683@1|root,COG0683@2|Bacteria,2I8ME@201174|Actinobacteria,4DBHM@85008|Micromonosporales	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_6420861_29	649831.L083_8142	1.889e-107	356.0	COG1834@1|root,COG1834@2|Bacteria,2GNTN@201174|Actinobacteria,4D8QB@85008|Micromonosporales	201174|Actinobacteria	E	Amidinotransferase	-	GO:0003674,GO:0003824,GO:0016403,GO:0016787,GO:0016810,GO:0016813	-	-	-	-	-	-	-	-	-	-	Amidinotransf
TLS2_k127_6420861_47	356851.JOAN01000004_gene1126	1.919e-68	236.0	COG1522@1|root,COG1522@2|Bacteria,2GN6I@201174|Actinobacteria,4DD2Z@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
TLS2_k127_6420861_11	644283.Micau_3030	1.337e-187	610.0	COG1948@1|root,COG4880@2|Bacteria,2I8JU@201174|Actinobacteria,4D8V4@85008|Micromonosporales	201174|Actinobacteria	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
TLS2_k127_6420861_18	644283.Micau_6235	8.381e-132	428.0	2EB78@1|root,3357V@2|Bacteria,2H0NN@201174|Actinobacteria,4DBB7@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6420861_3	390989.JOEG01000015_gene2831	0.0	1081.0	COG0243@1|root,COG0243@2|Bacteria,2GJWZ@201174|Actinobacteria,4D9WF@85008|Micromonosporales	201174|Actinobacteria	C	Molydopterin dinucleotide binding domain	fdhF	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
TLS2_k127_6420861_68	1236902.ANAS01000012_gene813	6.584e-15	81.0	2DR18@1|root,339RQ@2|Bacteria,2I6ZB@201174|Actinobacteria,4EKVG@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6420861_58	356851.JOAN01000004_gene1122	8.21e-50	184.0	COG0746@1|root,COG0746@2|Bacteria,2GJVE@201174|Actinobacteria,4DD9H@85008|Micromonosporales	201174|Actinobacteria	H	MobA-like NTP transferase domain	mobA	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
TLS2_k127_6420861_6	1121946.AUAX01000003_gene1843	4.539e-276	867.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4DBRK@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS2_k127_6420861_53	1121946.AUAX01000006_gene3517	8.121e-66	235.0	29J3Y@1|root,3061D@2|Bacteria,2IIBV@201174|Actinobacteria,4DDMG@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6420861_23	1440053.JOEI01000015_gene5524	5.161e-122	400.0	COG0329@1|root,COG0446@1|root,COG0329@2|Bacteria,COG0446@2|Bacteria,2GJM6@201174|Actinobacteria	201174|Actinobacteria	E	pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD,Pyr_redox_2
TLS2_k127_6420861_12	67352.JODS01000020_gene3909	1.18e-158	509.0	COG3938@1|root,COG3938@2|Bacteria,2GM47@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the proline racemase family	-	-	5.1.1.4	ko:K01777	ko00330,ko01100,map00330,map01100	-	R01255	RC00479	ko00000,ko00001,ko01000	-	-	-	Pro_racemase
TLS2_k127_6420861_25	1123320.KB889662_gene1564	1.779e-116	395.0	COG0665@1|root,COG0665@2|Bacteria,2GNAE@201174|Actinobacteria	201174|Actinobacteria	E	PFAM FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS2_k127_6420861_64	358823.DF19_06215	1.573e-34	135.0	COG3383@1|root,COG3383@2|Bacteria,2GSHP@201174|Actinobacteria	201174|Actinobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4
TLS2_k127_6420861_14	58344.JOEL01000001_gene451	3.535e-141	463.0	COG0446@1|root,COG0446@2|Bacteria,2GJM6@201174|Actinobacteria	201174|Actinobacteria	E	pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD,Pyr_redox_2
TLS2_k127_6420861_35	1120950.KB892788_gene29	7.662e-92	304.0	COG1576@1|root,COG1576@2|Bacteria,2I3MI@201174|Actinobacteria,4DQMN@85009|Propionibacteriales	201174|Actinobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,MDMPI_N
TLS2_k127_6420861_52	1449048.JQKU01000005_gene4673	5.839e-67	231.0	COG3832@1|root,COG3832@2|Bacteria,2IHTJ@201174|Actinobacteria,238SK@1762|Mycobacteriaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_6420861_61	1120950.KB892788_gene31	9.686e-48	173.0	COG0640@1|root,COG0640@2|Bacteria,2IKQY@201174|Actinobacteria,4DQZ4@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_6420861_37	1136417.AZWE01000011_gene3008	9.843e-90	304.0	COG1985@1|root,COG1985@2|Bacteria,2GKAX@201174|Actinobacteria,4DC5A@85008|Micromonosporales	201174|Actinobacteria	H	RibD C-terminal domain	ribG	-	1.1.1.193,3.5.4.26	ko:K00082,ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
TLS2_k127_6420861_57	391037.Sare_2571	3.085e-53	194.0	COG0117@1|root,COG0117@2|Bacteria,2IMY8@201174|Actinobacteria,4DFB7@85008|Micromonosporales	201174|Actinobacteria	H	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	dCMP_cyt_deam_1
TLS2_k127_6420861_60	33876.JNXY01000025_gene5344	1.257e-48	179.0	COG0789@1|root,COG0789@2|Bacteria,2IQJ4@201174|Actinobacteria,4DDT4@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	hspR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
TLS2_k127_6420861_15	68170.KL590470_gene11217	7.162e-138	450.0	COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,4DYUX@85010|Pseudonocardiales	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_6420861_48	263358.VAB18032_05080	4.871e-68	241.0	COG0576@1|root,COG0576@2|Bacteria,2GP4F@201174|Actinobacteria,4DBQX@85008|Micromonosporales	201174|Actinobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS2_k127_6420861_4	1121946.AUAX01000006_gene3458	0.0	1024.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4D8YG@85008|Micromonosporales	201174|Actinobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TLS2_k127_6420861_32	1150864.MILUP08_40120	2.554e-104	358.0	COG0699@1|root,COG0699@2|Bacteria,2GJX9@201174|Actinobacteria,4D9GS@85008|Micromonosporales	201174|Actinobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
TLS2_k127_6420861_17	356851.JOAN01000004_gene945	5.673e-132	438.0	COG0699@1|root,COG0699@2|Bacteria,2GM68@201174|Actinobacteria,4DAXS@85008|Micromonosporales	201174|Actinobacteria	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
TLS2_k127_6420861_19	1150864.MILUP08_40118	8.868e-131	428.0	COG3057@1|root,COG3057@2|Bacteria,2GP85@201174|Actinobacteria,4DCJH@85008|Micromonosporales	201174|Actinobacteria	L	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6420861_56	1246995.AFR_11035	5.066e-61	228.0	COG4585@1|root,COG4585@2|Bacteria,2GJ6F@201174|Actinobacteria,4DCTG@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS2_k127_6420861_39	1136417.AZWE01000018_gene1005	2.879e-87	296.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4D8XQ@85008|Micromonosporales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_6420861_2	219305.MCAG_05436	0.0	1084.0	COG0653@1|root,COG0653@2|Bacteria,2GKZE@201174|Actinobacteria,4DA57@85008|Micromonosporales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA2	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009405,GO:0009605,GO:0009607,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0035821,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043207,GO:0043492,GO:0043952,GO:0044003,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052564,GO:0052572,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0075136,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SecA_DEAD,SecA_PP_bind,SecA_SW
TLS2_k127_6420861_41	749927.AMED_6597	8.714e-83	310.0	COG4826@1|root,COG4826@2|Bacteria,2GJ5T@201174|Actinobacteria,4DYPH@85010|Pseudonocardiales	201174|Actinobacteria	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
TLS2_k127_6420861_34	645465.ACUR01000273_gene1672	6.999e-98	325.0	COG0789@1|root,COG0789@2|Bacteria,2H5GI@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	tipA	-	-	ko:K21744	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1,TipAS
TLS2_k127_6420861_7	1150864.MILUP08_46626	3.24e-263	843.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4D9AS@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,TPR_12,Trans_reg_C
TLS2_k127_6420861_20	1210045.ALNP01000021_gene492	2.051e-129	423.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_6420861_26	1463845.JOIG01000009_gene2852	2.157e-114	374.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
TLS2_k127_6420861_46	1464048.JNZS01000009_gene6050	1.273e-69	245.0	COG0631@1|root,COG0631@2|Bacteria,2IF31@201174|Actinobacteria,4DCIR@85008|Micromonosporales	201174|Actinobacteria	T	serine threonine protein phosphatase	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
TLS2_k127_6420861_42	219305.MCAG_02289	3.972e-77	268.0	COG0726@1|root,COG0726@2|Bacteria,2GN6G@201174|Actinobacteria,4D9UU@85008|Micromonosporales	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_6420861_13	1464048.JNZS01000009_gene6057	3.153e-141	462.0	COG2807@1|root,COG2807@2|Bacteria,2GP5W@201174|Actinobacteria,4D98P@85008|Micromonosporales	201174|Actinobacteria	P	Transporter	-	-	-	ko:K03449	-	-	-	-	ko00000,ko02000	2.A.1.17	-	-	MFS_1
TLS2_k127_6420861_30	390989.JOEG01000027_gene2173	1.331e-106	354.0	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria,4DBH9@85008|Micromonosporales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_6420861_55	1464048.JNZS01000013_gene3143	9.503e-64	222.0	COG1522@1|root,COG1522@2|Bacteria,2HA3J@201174|Actinobacteria,4DCRW@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_AsnC-type
TLS2_k127_6420861_66	391037.Sare_4511	2.636e-30	120.0	COG2452@1|root,COG2452@2|Bacteria,2GQJ9@201174|Actinobacteria,4DEV1@85008|Micromonosporales	201174|Actinobacteria	L	DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
TLS2_k127_6420861_28	219305.MCAG_03140	1.077e-107	351.0	COG0163@1|root,COG0163@2|Bacteria,2GKID@201174|Actinobacteria,4DAWI@85008|Micromonosporales	201174|Actinobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	ubiX	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
TLS2_k127_6420861_16	391037.Sare_4513	5.216e-135	444.0	COG0382@1|root,COG0382@2|Bacteria,2GJJ7@201174|Actinobacteria,4D9WH@85008|Micromonosporales	201174|Actinobacteria	H	4-hydroxybenzoate polyprenyltransferase	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TLS2_k127_6420861_5	1121272.KB903261_gene5915	4.742e-292	904.0	COG0043@1|root,COG0043@2|Bacteria,2GKSI@201174|Actinobacteria,4DAWA@85008|Micromonosporales	201174|Actinobacteria	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
TLS2_k127_6420861_59	469371.Tbis_1049	2.27e-49	191.0	COG1611@1|root,COG1611@2|Bacteria,2IN1B@201174|Actinobacteria,4E5V0@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TLS2_k127_6420861_22	1150864.MILUP08_46722	3.207e-126	410.0	COG0294@1|root,COG0294@2|Bacteria,2GJDQ@201174|Actinobacteria,4D8QV@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TLS2_k127_6420861_62	1869.MB27_38815	2.871e-47	172.0	COG1539@1|root,COG1539@2|Bacteria,2IHSW@201174|Actinobacteria,4DE5B@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	GO:0008150,GO:0040007	1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8	ko:K01633,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00840	R03503,R03504,R11037,R11073	RC00002,RC00017,RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
TLS2_k127_6420861_54	644283.Micau_5871	2.279e-64	226.0	COG0801@1|root,COG0801@2|Bacteria,2H3G6@201174|Actinobacteria,4DD6D@85008|Micromonosporales	201174|Actinobacteria	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
TLS2_k127_6420861_67	356851.JOAN01000015_gene2510	2.015e-29	124.0	2DRQG@1|root,33CMQ@2|Bacteria,2IFEG@201174|Actinobacteria,4DEJ0@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3180)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3180
TLS2_k127_6420861_40	1150864.MILUP08_46718	3.843e-84	298.0	COG1172@1|root,COG1172@2|Bacteria,2IC82@201174|Actinobacteria,4DBMY@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
TLS2_k127_6420861_65	1121272.KB903261_gene6464	6.908e-34	148.0	29W89@1|root,30HTJ@2|Bacteria,2IGWK@201174|Actinobacteria,4DF9Z@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6420861_10	1120949.KB903319_gene9743	4.32e-216	692.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4DACF@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS2_k127_6420861_27	1246995.AFR_41400	3.496e-108	362.0	COG1565@1|root,COG1565@2|Bacteria,2GKIU@201174|Actinobacteria,4DB5C@85008|Micromonosporales	201174|Actinobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
TLS2_k127_6420861_50	1464048.JNZS01000002_gene511	3.153e-67	230.0	COG0853@1|root,COG0853@2|Bacteria,2IHTC@201174|Actinobacteria,4DDKS@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
TLS2_k127_6420861_38	644283.Micau_5858	2.478e-88	308.0	COG0414@1|root,COG0414@2|Bacteria,2GJEQ@201174|Actinobacteria,4D99B@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
TLS2_k127_6420861_31	263358.VAB18032_02730	7.873e-105	348.0	COG5495@1|root,COG5495@2|Bacteria,2I2F6@201174|Actinobacteria,4DABD@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF2520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
TLS2_k127_6420861_43	1869.MB27_38875	6.44e-76	265.0	2BXNT@1|root,30VN0@2|Bacteria,2IH7X@201174|Actinobacteria,4DD7B@85008|Micromonosporales	201174|Actinobacteria	S	Septum formation	-	-	-	-	-	-	-	-	-	-	-	-	Septum_form
TLS2_k127_6420861_45	649831.L083_7858	2.971e-70	252.0	2BXNT@1|root,30VN0@2|Bacteria,2IH7X@201174|Actinobacteria,4DD7B@85008|Micromonosporales	201174|Actinobacteria	S	Septum formation	-	-	-	-	-	-	-	-	-	-	-	-	Septum_form
TLS2_k127_6420861_9	219305.MCAG_02402	5.062e-240	756.0	COG0029@1|root,COG0029@2|Bacteria,2I2IJ@201174|Actinobacteria,4D9BT@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_6420861_24	1150864.MILUP08_46701	6.693e-122	397.0	COG0157@1|root,COG0157@2|Bacteria,2I2IP@201174|Actinobacteria,4DAMZ@85008|Micromonosporales	201174|Actinobacteria	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
TLS2_k127_6420861_21	1121946.AUAX01000006_gene3597	7.682e-127	410.0	COG1521@1|root,COG1521@2|Bacteria,2GMRQ@201174|Actinobacteria,4D9W0@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
TLS2_k127_6420861_8	356851.JOAN01000015_gene2529	3.358e-242	758.0	COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria,4D8GZ@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	GO:0008150,GO:0040007	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
TLS2_k127_6420861_63	263358.VAB18032_02690	4.762e-35	138.0	2C4MW@1|root,32RKK@2|Bacteria,2IQ6A@201174|Actinobacteria,4DE2H@85008|Micromonosporales	201174|Actinobacteria	S	Lsr2	lsr2	GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009405,GO:0009605,GO:0009628,GO:0009636,GO:0009889,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010039,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031668,GO:0033554,GO:0034641,GO:0040007,GO:0042221,GO:0042262,GO:0042493,GO:0042542,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051704,GO:0051716,GO:0060255,GO:0065007,GO:0070482,GO:0070887,GO:0071453,GO:0071496,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	Lsr2
TLS2_k127_6420861_0	1869.MB27_38905	0.0	1480.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4D8QE@85008|Micromonosporales	201174|Actinobacteria	O	Clp amino terminal domain, pathogenicity island component	clpC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
TLS2_k127_6438319_3	35754.JNYJ01000028_gene6024	3.366e-72	247.0	2EXZN@1|root,33R8Q@2|Bacteria,2IDAW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	ko:K19132	-	-	-	-	ko00000,ko02048	-	-	-	-
TLS2_k127_6438319_0	35754.JNYJ01000028_gene6023	0.0	1112.0	COG1203@1|root,COG1203@2|Bacteria,2I266@201174|Actinobacteria,4DIVS@85008|Micromonosporales	201174|Actinobacteria	L	CRISPR-associated helicase Cas3	cas3	-	-	ko:K07012	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Helicase_C
TLS2_k127_6438319_2	35754.JNYJ01000028_gene6022	2.098e-146	473.0	2EXKP@1|root,33QWM@2|Bacteria,2II2B@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	ko:K19133	-	-	-	-	ko00000,ko02048	-	-	-	-
TLS2_k127_6438319_1	521393.JH806632_gene218	2.112e-199	634.0	COG1468@1|root,COG1518@1|root,COG1468@2|Bacteria,COG1518@2|Bacteria,2I8M0@201174|Actinobacteria,4D507@85005|Actinomycetales	201174|Actinobacteria	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	cas1	-	-	ko:K15342	-	-	-	-	ko00000,ko02048,ko03400	-	-	-	Cas_Cas1,Cas_Cas4
TLS2_k127_6438319_4	1121360.AUAQ01000019_gene2127	6.039e-23	104.0	COG1343@1|root,COG1343@2|Bacteria,2GXKQ@201174|Actinobacteria,22PAK@1653|Corynebacteriaceae	201174|Actinobacteria	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	cas2	-	-	ko:K09951	-	-	-	-	ko00000,ko02048	-	-	-	CRISPR_Cas2
TLS2_k127_6620289_24	644283.Micau_5649	2.371e-77	264.0	COG1595@1|root,COG1595@2|Bacteria,2GJER@201174|Actinobacteria,4DB56@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	adsA	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6620289_33	298654.FraEuI1c_6314	9.952e-24	102.0	COG0695@1|root,COG0695@2|Bacteria,2IR0P@201174|Actinobacteria,4ETIA@85013|Frankiales	201174|Actinobacteria	O	PFAM Glutaredoxin 2	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF836
TLS2_k127_6620289_23	644283.Micau_5646	2.854e-78	267.0	COG0546@1|root,COG0546@2|Bacteria,2GNCU@201174|Actinobacteria,4DC5V@85008|Micromonosporales	201174|Actinobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD,HAD_2,Hydrolase_like
TLS2_k127_6620289_20	219305.MCAG_02207	1.731e-93	319.0	COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria,4D9TJ@85008|Micromonosporales	201174|Actinobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
TLS2_k127_6620289_10	1150864.MILUP08_46464	6.199e-135	450.0	COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,4DBQN@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0008150,GO:0040007	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
TLS2_k127_6620289_17	1121946.AUAX01000003_gene1551	5.249e-106	354.0	COG0181@1|root,COG0181@2|Bacteria,2GMWI@201174|Actinobacteria,4D9YK@85008|Micromonosporales	201174|Actinobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0510	Porphobil_deam,Porphobil_deamC
TLS2_k127_6620289_2	1150864.MILUP08_46462	3.733e-265	826.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2GMJZ@201174|Actinobacteria,4D9RH@85008|Micromonosporales	201174|Actinobacteria	H	Uroporphyrinogen-III synthase HemD	hemD	-	2.1.1.107,4.2.1.75	ko:K01719,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
TLS2_k127_6620289_7	391037.Sare_0429	5.706e-162	514.0	COG0113@1|root,COG0113@2|Bacteria,2GJJ0@201174|Actinobacteria,4D999@85008|Micromonosporales	201174|Actinobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
TLS2_k127_6620289_37	1246995.AFR_42175	9.395e-11	74.0	2ES71@1|root,33JRT@2|Bacteria,2INW6@201174|Actinobacteria,4DFAE@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6620289_22	1464048.JNZS01000009_gene5654	1.685e-83	285.0	COG1266@1|root,COG1266@2|Bacteria,2GK11@201174|Actinobacteria,4D8SM@85008|Micromonosporales	201174|Actinobacteria	S	Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_6620289_12	1150864.MILUP08_30068	1.62e-123	403.0	COG0242@1|root,COG0242@2|Bacteria,2GJT4@201174|Actinobacteria,4DA7J@85008|Micromonosporales	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	HTH_31,Pep_deformylase
TLS2_k127_6620289_26	356851.JOAN01000004_gene1199	6.693e-59	214.0	COG4114@1|root,COG4114@2|Bacteria,2I16H@201174|Actinobacteria,4DCC7@85008|Micromonosporales	201174|Actinobacteria	S	ferric iron reductase	-	-	-	-	-	-	-	-	-	-	-	-	FhuF
TLS2_k127_6620289_21	1449976.KALB_3975	3.02e-84	287.0	COG3375@1|root,COG3375@2|Bacteria,2I8MV@201174|Actinobacteria,4DZFG@85010|Pseudonocardiales	201174|Actinobacteria	M	Mandelate Racemase Muconate Lactonizing	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6620289_6	1449976.KALB_2318	3.393e-165	526.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria,4E02U@85010|Pseudonocardiales	201174|Actinobacteria	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113,5.5.1.1	ko:K01856,ko:K02549	ko00130,ko00361,ko00362,ko00364,ko00623,ko01100,ko01110,ko01120,ko01220,map00130,map00361,map00362,map00364,map00623,map01100,map01110,map01120,map01220	M00116,M00568	R04031,R05300,R05390,R06989,R08116,R09229	RC00903,RC01038,RC01053,RC01108,RC01321,RC01356	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_6620289_4	1150864.MILUP08_45482	1.545e-193	644.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2IAS1@201174|Actinobacteria,4D9ME@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_12,Trans_reg_C
TLS2_k127_6620289_36	1121272.KB903253_gene6930	1.582e-13	78.0	2BCCA@1|root,325XP@2|Bacteria,2HB8A@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6620289_34	543632.JOJL01000004_gene4347	7.265e-23	103.0	COG0053@1|root,COG0053@2|Bacteria,2GJ8Q@201174|Actinobacteria,4DAXX@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TLS2_k127_6620289_0	882083.SacmaDRAFT_0113	0.0	1340.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4E1A0@85010|Pseudonocardiales	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB2	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS2_k127_6620289_32	1394178.AWOO02000004_gene2508	8.712e-30	131.0	COG0789@1|root,COG0789@2|Bacteria,2GRXI@201174|Actinobacteria,4EQ1Y@85012|Streptosporangiales	201174|Actinobacteria	K	MerR HTH family regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	MerR_2
TLS2_k127_6620289_15	1394178.AWOO02000004_gene2509	8.958e-118	386.0	COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,4EN7Z@85012|Streptosporangiales	201174|Actinobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
TLS2_k127_6620289_31	2002.JOEQ01000015_gene4993	8.739e-37	153.0	COG0576@1|root,COG0576@2|Bacteria,2IKK4@201174|Actinobacteria,4EPKS@85012|Streptosporangiales	201174|Actinobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE2	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS2_k127_6620289_1	479432.Sros_4022	8.041e-310	961.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4ENEE@85012|Streptosporangiales	201174|Actinobacteria	O	MreB/Mbl protein	-	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TLS2_k127_6620289_30	106370.Francci3_2174	2.061e-41	156.0	COG0071@1|root,COG0071@2|Bacteria,2IRG0@201174|Actinobacteria,4ET0C@85013|Frankiales	201174|Actinobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS2_k127_6620289_8	369723.Strop_3393	1.85e-150	508.0	COG2909@1|root,COG2909@2|Bacteria,2IDM6@201174|Actinobacteria,4DCIQ@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE
TLS2_k127_6620289_11	644283.Micau_6158	6.443e-135	438.0	COG0604@1|root,COG0604@2|Bacteria,2GN47@201174|Actinobacteria,4D8ZC@85008|Micromonosporales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
TLS2_k127_6620289_27	33876.JNXY01000037_gene7974	4.91e-58	207.0	COG0789@1|root,COG0789@2|Bacteria,2GKTU@201174|Actinobacteria,4DDKX@85008|Micromonosporales	201174|Actinobacteria	K	redox-sensitive transcriptional activator SoxR	soxR	-	-	ko:K13639	-	-	-	-	ko00000,ko03000	-	-	-	MerR,MerR-DNA-bind,MerR_1
TLS2_k127_6620289_19	1464048.JNZS01000009_gene5665	6.849e-94	313.0	COG3959@1|root,COG3959@2|Bacteria,2GNWW@201174|Actinobacteria,4D97H@85008|Micromonosporales	201174|Actinobacteria	G	Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS2_k127_6620289_13	1464048.JNZS01000009_gene5666	2.006e-122	400.0	COG3958@1|root,COG3958@2|Bacteria,2GN1R@201174|Actinobacteria,4DAGZ@85008|Micromonosporales	201174|Actinobacteria	G	Transketolase, central region	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_6620289_14	1464048.JNZS01000009_gene5667	4.006e-122	394.0	COG1215@1|root,COG1215@2|Bacteria,2GP1D@201174|Actinobacteria,4DBWM@85008|Micromonosporales	201174|Actinobacteria	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_6620289_39	479434.Sthe_0287	9.572e-09	68.0	2DTR9@1|root,33MCT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6620289_35	1122138.AQUZ01000030_gene4688	1.417e-18	96.0	2DTR9@1|root,33MCT@2|Bacteria,2GTA3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6620289_16	33876.JNXY01000027_gene3668	6.233e-110	368.0	COG1131@1|root,COG1131@2|Bacteria,2GRE8@201174|Actinobacteria,4DAZJ@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	AAA_21,ABC_tran
TLS2_k127_6620289_28	479434.Sthe_0285	2.017e-46	174.0	COG1725@1|root,COG1725@2|Bacteria,2G99C@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein GntR HTH	-	-	-	-	-	-	-	-	-	-	-	-	GntR
TLS2_k127_6620289_25	1150864.MILUP08_30183	1.413e-60	230.0	COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4DC71@85008|Micromonosporales	201174|Actinobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
TLS2_k127_6620289_3	644283.Micau_5805	5.138e-227	711.0	COG0215@1|root,COG0215@2|Bacteria,2GJF2@201174|Actinobacteria,4D9DJ@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
TLS2_k127_6620289_9	35754.JNYJ01000036_gene3669	2.905e-144	466.0	COG0566@1|root,COG0566@2|Bacteria,2GJMR@201174|Actinobacteria,4D9GN@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	rlmB	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS2_k127_6620289_40	246197.MXAN_1497	0.0004382	53.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PQQ_2,PQQ_3,Pkinase
TLS2_k127_6620289_5	644283.Micau_5803	1.531e-187	593.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4D9U3@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
TLS2_k127_6620289_29	356851.JOAN01000015_gene2602	3.365e-45	177.0	COG0671@1|root,COG0671@2|Bacteria,2HGFW@201174|Actinobacteria,4DEMJ@85008|Micromonosporales	201174|Actinobacteria	I	Phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS2_k127_6620289_18	1150864.MILUP08_46623	5.242e-102	348.0	COG0531@1|root,COG0531@2|Bacteria,2GJ75@201174|Actinobacteria,4D9TG@85008|Micromonosporales	201174|Actinobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease,AA_permease_2
TLS2_k127_6627640_2	1150864.MILUP08_41470	1.258e-166	531.0	COG1228@1|root,COG1228@2|Bacteria,2GKRZ@201174|Actinobacteria,4D9II@85008|Micromonosporales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_6627640_0	263358.VAB18032_11570	1.629e-262	823.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,4DAEH@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
TLS2_k127_6627640_14	1121946.AUAX01000014_gene1054	1.815e-50	189.0	COG0228@1|root,COG0228@2|Bacteria,2IKU0@201174|Actinobacteria,4DDRR@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TLS2_k127_6627640_16	391037.Sare_1195	2.197e-37	147.0	COG1837@1|root,COG1837@2|Bacteria,2IQ4C@201174|Actinobacteria,4DF6C@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the UPF0109 family	-	GO:0008150,GO:0040007	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
TLS2_k127_6627640_10	1150864.MILUP08_41482	6.944e-65	228.0	COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,4DD1W@85008|Micromonosporales	201174|Actinobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0008150,GO:0040007	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
TLS2_k127_6627640_3	1464048.JNZS01000017_gene3612	1.978e-127	411.0	COG0336@1|root,COG0336@2|Bacteria,2GJ1G@201174|Actinobacteria,4D994@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,tRNA_m1G_MT
TLS2_k127_6627640_12	263358.VAB18032_11600	5.144e-58	211.0	COG0335@1|root,COG0335@2|Bacteria,2IHRT@201174|Actinobacteria,4DDE0@85008|Micromonosporales	201174|Actinobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
TLS2_k127_6627640_7	356851.JOAN01000003_gene1672	4.526e-105	358.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4DBDV@85008|Micromonosporales	201174|Actinobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS2_k127_6627640_9	219305.MCAG_04277	2.453e-94	314.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4DAXU@85008|Micromonosporales	201174|Actinobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
TLS2_k127_6627640_8	1246995.AFR_36290	5.555e-103	340.0	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,4DA93@85008|Micromonosporales	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
TLS2_k127_6627640_11	1464048.JNZS01000017_gene3606	1.241e-60	210.0	2AFXT@1|root,3161G@2|Bacteria,2IKPZ@201174|Actinobacteria,4DDG2@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF2469)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2469
TLS2_k127_6627640_13	1464048.JNZS01000017_gene3604	1.846e-56	204.0	COG0739@1|root,COG0739@2|Bacteria,2IQ64@201174|Actinobacteria,4DEE2@85008|Micromonosporales	201174|Actinobacteria	M	peptidase M23B	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_6627640_15	512565.AMIS_70100	8.299e-41	155.0	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4DEGG@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the UPF0102 family	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
TLS2_k127_6627640_1	1150864.MILUP08_41497	1.651e-220	698.0	COG0606@1|root,COG0606@2|Bacteria,2GJIQ@201174|Actinobacteria,4DB4N@85008|Micromonosporales	201174|Actinobacteria	O	Magnesium chelatase, subunit ChlI C-terminal	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
TLS2_k127_6627640_6	644283.Micau_1403	2.646e-107	362.0	COG0758@1|root,COG0758@2|Bacteria,2GKDA@201174|Actinobacteria,4D9NE@85008|Micromonosporales	201174|Actinobacteria	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
TLS2_k127_6627640_4	644283.Micau_1401	9.107e-121	400.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4D9Q9@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_6627640_17	1120949.KB903356_gene8621	2.424e-09	66.0	290QF@1|root,2ZNCM@2|Bacteria,2H1M7@201174|Actinobacteria,4DGKD@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6627640_5	1229780.BN381_330051	1.111e-114	382.0	COG0052@1|root,COG0052@2|Bacteria,2GMYC@201174|Actinobacteria,3UWBA@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
TLS2_k127_6631161_2	1150864.MILUP08_40155	4.589e-43	166.0	COG1595@1|root,COG1595@2|Bacteria,2GP2X@201174|Actinobacteria,4DENG@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6631161_0	1463921.JODF01000007_gene6011	6.554e-88	293.0	COG1335@1|root,COG1335@2|Bacteria,2IG6Q@201174|Actinobacteria	201174|Actinobacteria	Q	isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS2_k127_6631161_1	1476876.JOJO01000048_gene6238	5.922e-83	283.0	COG2258@1|root,COG2258@2|Bacteria,2GMCN@201174|Actinobacteria	201174|Actinobacteria	C	PFAM MOSC domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
TLS2_k127_6631161_3	882082.SaccyDRAFT_4419	2.479e-08	57.0	COG3209@1|root,COG3534@1|root,COG3209@2|Bacteria,COG3534@2|Bacteria,2I35N@201174|Actinobacteria,4DYH2@85010|Pseudonocardiales	201174|Actinobacteria	M	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,VCBS
TLS2_k127_6631161_4	1210045.ALNP01000015_gene1571	3.851e-05	51.0	COG2755@1|root,COG3209@1|root,COG3534@1|root,COG2755@2|Bacteria,COG3209@2|Bacteria,COG3534@2|Bacteria,2GK1D@201174|Actinobacteria	201174|Actinobacteria	M	TIGRFAM YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,RHS_repeat
TLS2_k127_6639325_6	219305.MCAG_04871	5.543e-21	93.0	COG0703@1|root,COG0703@2|Bacteria,2GRFW@201174|Actinobacteria,4DDUR@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
TLS2_k127_6639325_3	1442599.JAAN01000035_gene641	8.278e-94	323.0	COG1228@1|root,COG1228@2|Bacteria,1RCA0@1224|Proteobacteria,1S08B@1236|Gammaproteobacteria,1X5NR@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,CIA30
TLS2_k127_6639325_0	1123065.ATWL01000002_gene1500	6.314e-113	373.0	COG3221@1|root,COG3221@2|Bacteria,2I7EX@201174|Actinobacteria	201174|Actinobacteria	P	COG3221 ABC-type phosphate phosphonate transport system, periplasmic component	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
TLS2_k127_6639325_1	1348338.ADILRU_0593	8.529e-112	366.0	COG3638@1|root,COG3638@2|Bacteria,2GK02@201174|Actinobacteria,4FKWP@85023|Microbacteriaceae	201174|Actinobacteria	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
TLS2_k127_6639325_4	1348338.ADILRU_0594	3.046e-80	276.0	COG3639@1|root,COG3639@2|Bacteria,2IAPI@201174|Actinobacteria,4FMKD@85023|Microbacteriaceae	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
TLS2_k127_6639325_2	1348338.ADILRU_0595	1.047e-105	361.0	COG3639@1|root,COG3639@2|Bacteria,2IAPI@201174|Actinobacteria,4FMKV@85023|Microbacteriaceae	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
TLS2_k127_6639325_5	219305.MCAG_04874	1.047e-35	138.0	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria,4D9CC@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
TLS2_k127_6644480_8	33876.JNXY01000001_gene5620	6.243e-30	118.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4DC6X@85008|Micromonosporales	201174|Actinobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	garA	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
TLS2_k127_6644480_5	356851.JOAN01000035_gene1939	2.264e-82	277.0	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,4D9DY@85008|Micromonosporales	201174|Actinobacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
TLS2_k127_6644480_2	105425.BBPL01000016_gene2534	1.241e-285	908.0	COG4403@1|root,COG4403@2|Bacteria,2GKVV@201174|Actinobacteria,2NI0D@228398|Streptacidiphilus	201174|Actinobacteria	V	Domain of unknown function (DUF4135)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4135,LANC_like
TLS2_k127_6644480_6	1121946.AUAX01000004_gene740	9.878e-73	250.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,4DB9Y@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_6644480_0	1246995.AFR_21195	0.0	1429.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria,4D9B1@85008|Micromonosporales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
TLS2_k127_6644480_9	479433.Caci_4776	2.571e-26	110.0	2E60G@1|root,330PX@2|Bacteria,2GQQ5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6644480_3	35754.JNYJ01000003_gene6433	3.645e-158	519.0	COG2304@1|root,COG2304@2|Bacteria,2GUB3@201174|Actinobacteria,4DC1B@85008|Micromonosporales	201174|Actinobacteria	S	von Willebrand factor, type A	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	SBP_bac_11,VWA,VWA_2
TLS2_k127_6644480_7	219305.MCAG_00136	4.274e-68	236.0	COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,4DBXQ@85008|Micromonosporales	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TLS2_k127_6644480_4	1192034.CAP_3747	1.424e-147	479.0	COG4264@1|root,COG4264@2|Bacteria,1RGMY@1224|Proteobacteria	1224|Proteobacteria	Q	IucA IucC family	-	-	-	-	-	-	-	-	-	-	-	-	IucA_IucC
TLS2_k127_6644480_1	644283.Micau_2167	0.0	1281.0	COG4581@1|root,COG4581@2|Bacteria,2GJSV@201174|Actinobacteria,4D93J@85008|Micromonosporales	201174|Actinobacteria	L	DEAD DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DUF3516,Helicase_C
TLS2_k127_6655084_2	321955.AAGP01000004_gene2840	2.343e-75	282.0	COG0553@1|root,COG0827@1|root,COG4646@1|root,COG0553@2|Bacteria,COG0827@2|Bacteria,COG4646@2|Bacteria,2I378@201174|Actinobacteria,4FAN9@85019|Brevibacteriaceae	201174|Actinobacteria	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII,SNF2_N
TLS2_k127_6655084_5	1043205.AFYF01000072_gene2217	4.523e-21	98.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4FF88@85021|Intrasporangiaceae	201174|Actinobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_6655084_4	1869.MB27_38545	3.843e-31	134.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,4DBBT@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS2_k127_6655084_0	479435.Kfla_1086	7.965e-143	461.0	COG3214@1|root,COG3214@2|Bacteria,2HZVF@201174|Actinobacteria,4DU7Q@85009|Propionibacteriales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS2_k127_6655084_3	1179773.BN6_57060	6.218e-36	141.0	COG2963@1|root,COG2963@2|Bacteria,2GR4Q@201174|Actinobacteria,4EC9T@85010|Pseudonocardiales	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
TLS2_k127_6655084_1	1133849.O3I_024835	4.102e-133	429.0	COG2801@1|root,COG2801@2|Bacteria,2GKW1@201174|Actinobacteria,4FWER@85025|Nocardiaceae	201174|Actinobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
TLS2_k127_6655084_6	1120934.KB894407_gene5156	1.996e-08	60.0	COG3335@1|root,COG3335@2|Bacteria,2GJQI@201174|Actinobacteria,4ECC2@85010|Pseudonocardiales	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
TLS2_k127_666281_6	1150864.MILUP08_45878	2.369e-168	539.0	COG3599@1|root,COG3599@2|Bacteria,2I2UK@201174|Actinobacteria,4D9JS@85008|Micromonosporales	201174|Actinobacteria	D	regulation of cell shape	-	-	-	-	-	-	-	-	-	-	-	-	DivIVA
TLS2_k127_666281_27	219305.MCAG_01719	2.105e-51	200.0	COG1196@1|root,COG1196@2|Bacteria,2I5H7@201174|Actinobacteria,4DBSF@85008|Micromonosporales	201174|Actinobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_666281_17	1136417.AZWE01000078_gene256	9.824e-112	365.0	COG1131@1|root,COG1131@2|Bacteria,2GNQJ@201174|Actinobacteria,4DHVP@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_666281_11	1136417.AZWE01000078_gene255	5.72e-131	431.0	2EMPW@1|root,33FCB@2|Bacteria,2IGWD@201174|Actinobacteria,4DITW@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_666281_30	1463895.JODA01000029_gene5824	7.002e-31	130.0	2C6PV@1|root,2ZU0T@2|Bacteria,2GRVX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_666281_23	543632.JOJL01000006_gene9557	1.406e-92	309.0	COG2120@1|root,COG2120@2|Bacteria,2GMXC@201174|Actinobacteria,4DBWA@85008|Micromonosporales	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_666281_13	543632.JOJL01000006_gene9558	2.899e-128	422.0	COG1208@1|root,COG1208@2|Bacteria,2GKHA@201174|Actinobacteria,4DBNB@85008|Micromonosporales	201174|Actinobacteria	JM	Glucose-1-phosphate cytidylyltransferase	rfbF	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
TLS2_k127_666281_2	543632.JOJL01000006_gene9559	1.567e-189	601.0	COG2230@1|root,COG2230@2|Bacteria,2I3YR@201174|Actinobacteria,4DMG1@85008|Micromonosporales	201174|Actinobacteria	M	C-methyltransferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
TLS2_k127_666281_5	1120949.KB903294_gene3676	5.109e-170	542.0	COG2227@1|root,COG2227@2|Bacteria,2ICWV@201174|Actinobacteria,4DAF7@85008|Micromonosporales	201174|Actinobacteria	H	C-methyltransferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
TLS2_k127_666281_9	543632.JOJL01000010_gene7231	7.716e-146	469.0	COG0451@1|root,COG0451@2|Bacteria,2GNYX@201174|Actinobacteria,4D91F@85008|Micromonosporales	201174|Actinobacteria	GM	GDP-mannose 4,6 dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_666281_21	272134.KB731324_gene3608	4.443e-100	335.0	COG0115@1|root,COG0115@2|Bacteria,1G1GM@1117|Cyanobacteria,1H8CZ@1150|Oscillatoriales	1117|Cyanobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS2_k127_666281_25	33876.JNXY01000008_gene8435	1.47e-73	259.0	COG0463@1|root,COG0463@2|Bacteria,2GKGN@201174|Actinobacteria,4DG1V@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_666281_20	1089544.KB912942_gene5595	1.99e-102	343.0	2ART5@1|root,31H4G@2|Bacteria,2I83W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_666281_28	33876.JNXY01000008_gene8441	5.911e-32	138.0	COG3206@1|root,COG3206@2|Bacteria,2GTC2@201174|Actinobacteria,4DFW3@85008|Micromonosporales	201174|Actinobacteria	M	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_666281_12	33876.JNXY01000008_gene8442	4.837e-130	430.0	COG3307@1|root,COG3307@2|Bacteria,2ICRB@201174|Actinobacteria,4DB4R@85008|Micromonosporales	201174|Actinobacteria	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TLS2_k127_666281_14	1246995.AFR_15980	8.702e-125	411.0	COG0438@1|root,COG0438@2|Bacteria,2IBEM@201174|Actinobacteria,4DCC9@85008|Micromonosporales	201174|Actinobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
TLS2_k127_666281_15	1121272.KB903272_gene127	2.834e-114	388.0	COG2244@1|root,COG2244@2|Bacteria,2H55P@201174|Actinobacteria,4D9TZ@85008|Micromonosporales	201174|Actinobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3,Polysacc_synt_C
TLS2_k127_666281_33	1500257.JQNM01000024_gene30	2.25e-26	121.0	COG3420@1|root,COG3420@2|Bacteria,1Q7GT@1224|Proteobacteria,2VDN5@28211|Alphaproteobacteria,4BIQA@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
TLS2_k127_666281_29	1120949.KB903321_gene2710	6.499e-32	141.0	COG2120@1|root,COG2120@2|Bacteria,2GWZT@201174|Actinobacteria	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_666281_19	1246995.AFR_15950	1.2e-102	358.0	2DMPU@1|root,32SXW@2|Bacteria,2IABF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_666281_1	1246995.AFR_15945	4.624e-214	676.0	COG0318@1|root,COG0318@2|Bacteria,2GMA0@201174|Actinobacteria,4DHDJ@85008|Micromonosporales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_666281_3	1246995.AFR_15940	3.284e-189	602.0	COG0019@1|root,COG0019@2|Bacteria,2GIT5@201174|Actinobacteria,4DAPK@85008|Micromonosporales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase, C-terminal sheet domain	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS2_k127_666281_32	1246995.AFR_15935	8.733e-27	111.0	COG0236@1|root,COG0236@2|Bacteria,2GYZ2@201174|Actinobacteria	201174|Actinobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
TLS2_k127_666281_4	1246995.AFR_15995	9.913e-180	573.0	COG0438@1|root,COG0438@2|Bacteria,2GSQI@201174|Actinobacteria,4DBSY@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
TLS2_k127_666281_22	1246995.AFR_16000	1.823e-95	323.0	COG1215@1|root,COG1215@2|Bacteria,2GJP7@201174|Actinobacteria,4DD53@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_666281_16	33876.JNXY01000008_gene8431	9.286e-114	381.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,4DA9T@85008|Micromonosporales	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
TLS2_k127_666281_24	644283.Micau_1177	9.35e-83	286.0	COG1898@1|root,COG1898@2|Bacteria,2GMW4@201174|Actinobacteria,4DHD8@85008|Micromonosporales	201174|Actinobacteria	M	dTDP-4-dehydrorhamnose 3,5-epimerase	rmlC	-	5.1.3.13	ko:K01790,ko:K16438	ko00404,ko00521,ko00523,ko01055,ko01130,map00404,map00521,map00523,map01055,map01130	M00793,M00798,M00799,M00800	R06433,R06514,R06628,R08934,R11046,R11138	RC01518,RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
TLS2_k127_666281_10	981369.JQMJ01000004_gene3195	3.027e-140	450.0	COG1209@1|root,COG1209@2|Bacteria,2GP20@201174|Actinobacteria,2NGTG@228398|Streptacidiphilus	201174|Actinobacteria	M	Nucleotidyl transferase	rfbA	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005996,GO:0006006,GO:0006139,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009117,GO:0009141,GO:0009147,GO:0009200,GO:0009211,GO:0009219,GO:0009225,GO:0009226,GO:0009262,GO:0009394,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019299,GO:0019300,GO:0019305,GO:0019318,GO:0019319,GO:0019438,GO:0019637,GO:0019692,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0045226,GO:0046075,GO:0046364,GO:0046379,GO:0046383,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0334	NTP_transferase
TLS2_k127_666281_7	928724.SacglDRAFT_00676	5.114e-161	517.0	COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria,4E023@85010|Pseudonocardiales	201174|Actinobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_666281_18	67352.JODS01000006_gene6449	2.947e-108	358.0	COG1091@1|root,COG1091@2|Bacteria,2GNY8@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rmlD	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
TLS2_k127_666281_8	471852.Tcur_1001	5.224e-155	507.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,4EGMN@85012|Streptosporangiales	201174|Actinobacteria	M	Bacterial sugar transferase	rfbP	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS2_k127_666281_31	369723.Strop_3617	1.04e-27	130.0	2E3EP@1|root,32YDP@2|Bacteria,2GQST@201174|Actinobacteria,4DFB0@85008|Micromonosporales	201174|Actinobacteria	S	ATP- GTP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_666281_0	1120936.KB907220_gene1981	1.774e-222	714.0	COG1506@1|root,COG1506@2|Bacteria,2GNG5@201174|Actinobacteria,4EG6K@85012|Streptosporangiales	201174|Actinobacteria	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_666281_26	1121946.AUAX01000009_gene4347	3.839e-61	218.0	COG2267@1|root,COG2267@2|Bacteria,2HUEM@201174|Actinobacteria,4DEP2@85008|Micromonosporales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_6687691_1	345341.KUTG_00290	7.896e-257	829.0	COG0515@1|root,COG4403@1|root,COG0515@2|Bacteria,COG4403@2|Bacteria,2GMRN@201174|Actinobacteria,4E17J@85010|Pseudonocardiales	201174|Actinobacteria	KLTV	Lanthionine synthetase C-like protein	amfT	-	-	-	-	-	-	-	-	-	-	-	LANC_like,Pkinase
TLS2_k127_6687691_0	649831.L083_6880	1.42e-265	824.0	COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria,4DA22@85008|Micromonosporales	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TLS2_k127_669434_42	134676.ACPL_7716	1.732e-24	105.0	COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria,4DA2U@85008|Micromonosporales	201174|Actinobacteria	H	Biotin protein ligase C terminal domain	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
TLS2_k127_669434_21	644283.Micau_0851	2.32e-72	254.0	COG3428@1|root,COG3428@2|Bacteria,2GK6Y@201174|Actinobacteria,4DD6M@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
TLS2_k127_669434_25	356851.JOAN01000001_gene3801	4.8e-62	217.0	COG2030@1|root,COG2030@2|Bacteria,2HFAT@201174|Actinobacteria,4DEX6@85008|Micromonosporales	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS2_k127_669434_33	33876.JNXY01000010_gene2519	4.987e-47	174.0	COG2246@1|root,COG2246@2|Bacteria,2IFFV@201174|Actinobacteria,4DDKD@85008|Micromonosporales	201174|Actinobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
TLS2_k127_669434_30	1122182.KB903813_gene2619	6.52e-52	188.0	COG2246@1|root,COG2246@2|Bacteria,2IFFV@201174|Actinobacteria,4DEIC@85008|Micromonosporales	201174|Actinobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
TLS2_k127_669434_47	1120949.KB903306_gene7282	1.112e-10	64.0	COG1595@1|root,COG1595@2|Bacteria,2GJFK@201174|Actinobacteria,4DC3B@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2,zf-HC2
TLS2_k127_669434_0	446470.Snas_0731	0.0	1069.0	COG1274@1|root,COG1274@2|Bacteria,2GJH3@201174|Actinobacteria,4EY93@85014|Glycomycetales	201174|Actinobacteria	C	Phosphoenolpyruvate carboxykinase C-terminal P-loop domain	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
TLS2_k127_669434_52	68170.KL590525_gene3048	0.0002845	49.0	COG0457@1|root,COG0457@2|Bacteria,2INUN@201174|Actinobacteria,4EFCT@85010|Pseudonocardiales	201174|Actinobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,TPR_12,TPR_7
TLS2_k127_669434_43	1394178.AWOO02000006_gene3378	1.453e-22	105.0	COG0681@1|root,COG0681@2|Bacteria,2GQUN@201174|Actinobacteria,4EKK8@85012|Streptosporangiales	201174|Actinobacteria	U	Peptidase S24-like	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS2_k127_669434_12	219305.MCAG_03687	3.37e-131	424.0	COG0020@1|root,COG0020@2|Bacteria,2GJCP@201174|Actinobacteria,4D8M5@85008|Micromonosporales	201174|Actinobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS2	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS2_k127_669434_2	356851.JOAN01000001_gene3813	2.985e-225	703.0	COG1875@1|root,COG1875@2|Bacteria,2GK8U@201174|Actinobacteria,4D9BM@85008|Micromonosporales	201174|Actinobacteria	T	ATPase related to phosphate starvation-inducible protein PhoH	phoH2	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
TLS2_k127_669434_32	1464048.JNZS01000004_gene1277	1.087e-49	186.0	COG0741@1|root,COG0741@2|Bacteria,2GM11@201174|Actinobacteria,4DD6V@85008|Micromonosporales	201174|Actinobacteria	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TLS2_k127_669434_45	1120949.KB903350_gene8435	1.176e-13	78.0	COG0789@1|root,COG0789@2|Bacteria,2I9B3@201174|Actinobacteria,4DEMK@85008|Micromonosporales	201174|Actinobacteria	K	MerR HTH family regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_669434_50	1121946.AUAX01000009_gene4412	3.068e-06	51.0	2DKWS@1|root,30N64@2|Bacteria,2IQR3@201174|Actinobacteria,4DEQQ@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4188)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4188
TLS2_k127_669434_20	35754.JNYJ01000007_gene2769	5.612e-79	271.0	COG0705@1|root,COG0705@2|Bacteria,2HCGE@201174|Actinobacteria,4DCPQ@85008|Micromonosporales	201174|Actinobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS2_k127_669434_10	219305.MCAG_03696	1.668e-156	500.0	COG0492@1|root,COG0492@2|Bacteria,2GJ1Z@201174|Actinobacteria,4DA8I@85008|Micromonosporales	201174|Actinobacteria	C	oxidoreductase activity, acting on iron-sulfur proteins as donors	-	-	1.18.1.2,1.19.1.1	ko:K21567	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_669434_19	1246995.AFR_39230	4.678e-86	295.0	COG3238@1|root,COG3238@2|Bacteria,2IB1U@201174|Actinobacteria,4DBCE@85008|Micromonosporales	201174|Actinobacteria	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
TLS2_k127_669434_6	263358.VAB18032_09035	2.854e-186	586.0	COG1494@1|root,COG1494@2|Bacteria,2GMQU@201174|Actinobacteria,4DASR@85008|Micromonosporales	201174|Actinobacteria	G	fructose-1,6-bisphosphatase	glpX	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
TLS2_k127_669434_41	219305.MCAG_03701	1.786e-30	133.0	2EID2@1|root,33C4E@2|Bacteria,2HUFY@201174|Actinobacteria,4DEVX@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF4245)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4245
TLS2_k127_669434_44	391037.Sare_0822	5.606e-19	88.0	COG1722@1|root,COG1722@2|Bacteria,2GR0U@201174|Actinobacteria,4DFQB@85008|Micromonosporales	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
TLS2_k127_669434_51	1089544.KB912942_gene1335	9.46e-05	50.0	2DDTR@1|root,2ZJ8E@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3060)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3060
TLS2_k127_669434_1	263358.VAB18032_00455	4.818e-233	731.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,2GMUK@201174|Actinobacteria,4D9IP@85008|Micromonosporales	201174|Actinobacteria	P	Adenylylsulfate kinase	cysC	-	2.7.1.25,2.7.7.4	ko:K00860,ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
TLS2_k127_669434_34	1122611.KB903959_gene4173	5.693e-47	191.0	2B6ZG@1|root,31ZZT@2|Bacteria,2H36G@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_669434_28	1116232.AHBF01000125_gene9400	3.408e-57	213.0	2B6QV@1|root,31ZPN@2|Bacteria,2H2FF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_669434_40	1123252.ATZF01000017_gene1718	2.103e-32	137.0	COG2267@1|root,COG2267@2|Bacteria,1UHSX@1239|Firmicutes,4IS8N@91061|Bacilli	91061|Bacilli	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_669434_13	649831.L083_1468	1.143e-129	429.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4D8JK@85008|Micromonosporales	201174|Actinobacteria	IQ	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_669434_29	1206732.BAGD01000084_gene3632	2.193e-54	196.0	2C9IE@1|root,31AT3@2|Bacteria,2IM6M@201174|Actinobacteria,4G1K7@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4383
TLS2_k127_669434_15	471853.Bcav_0264	6.8e-114	380.0	COG0451@1|root,COG0451@2|Bacteria,2I2SW@201174|Actinobacteria	201174|Actinobacteria	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_669434_22	33876.JNXY01000035_gene752	2.335e-72	251.0	COG0220@1|root,COG0220@2|Bacteria,2GJ8R@201174|Actinobacteria,4DCWE@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
TLS2_k127_669434_48	1229780.BN381_130143	2.186e-09	63.0	2DREZ@1|root,33BFB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_669434_38	1237500.ANBA01000003_gene4797	1.567e-33	140.0	COG1802@1|root,COG1802@2|Bacteria,2H1S8@201174|Actinobacteria,4EIKS@85012|Streptosporangiales	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_669434_26	891968.Anamo_1400	8.082e-61	231.0	COG1620@1|root,COG1620@2|Bacteria,3TBC8@508458|Synergistetes	508458|Synergistetes	C	L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
TLS2_k127_669434_46	1125973.JNLC01000011_gene575	4.056e-13	73.0	COG5276@1|root,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria,3JUB5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_669434_14	1136417.AZWE01000061_gene852	9.938e-123	418.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria,4D9ZY@85008|Micromonosporales	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050790,GO:0050896,GO:0051340,GO:0051351,GO:0051716,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
TLS2_k127_669434_11	1089545.KB913037_gene8712	6.902e-135	458.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria,4DXSI@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA polymerase LigD, polymerase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS2_k127_669434_5	391037.Sare_0456	1.144e-189	601.0	COG0014@1|root,COG0014@2|Bacteria,2GISA@201174|Actinobacteria,4D8FC@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2427c	Aldedh
TLS2_k127_669434_7	644283.Micau_5578	1.408e-173	554.0	COG0263@1|root,COG0263@2|Bacteria,2GM8U@201174|Actinobacteria,4DAWQ@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
TLS2_k127_669434_36	219305.MCAG_02153	3.849e-37	150.0	COG3695@1|root,COG3695@2|Bacteria,2GQMD@201174|Actinobacteria,4DET5@85008|Micromonosporales	201174|Actinobacteria	L	cysteine	-	-	-	-	-	-	-	-	-	-	-	-	DNA_binding_1
TLS2_k127_669434_37	765912.Thimo_1284	3.936e-34	132.0	COG4118@1|root,COG4118@2|Bacteria,1Q43R@1224|Proteobacteria,1SFET@1236|Gammaproteobacteria,1WZCQ@135613|Chromatiales	135613|Chromatiales	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS2_k127_669434_31	631362.Thi970DRAFT_03721	8.649e-52	186.0	COG3744@1|root,COG3744@2|Bacteria,1N0J5@1224|Proteobacteria,1SBIA@1236|Gammaproteobacteria,1WZ1X@135613|Chromatiales	135613|Chromatiales	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_669434_49	1214101.BN159_0183	3.771e-08	58.0	COG3385@1|root,COG3385@2|Bacteria,2GKQB@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
TLS2_k127_669434_9	1246995.AFR_04185	1.703e-167	540.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4D95N@85008|Micromonosporales	201174|Actinobacteria	E	Gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_669434_16	356851.JOAN01000013_gene5714	6.935e-102	337.0	COG0377@1|root,COG0377@2|Bacteria,2GJP5@201174|Actinobacteria,4D9WR@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB2	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TLS2_k127_669434_53	313589.JNB_09179	0.0006817	46.0	2BSTJ@1|root,32MX0@2|Bacteria,2GY5J@201174|Actinobacteria,4FHZZ@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_669434_39	1121017.AUFG01000035_gene694	1.309e-32	131.0	COG4113@1|root,COG4113@2|Bacteria,2GR4U@201174|Actinobacteria,4FHJX@85021|Intrasporangiaceae	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_669434_18	1464048.JNZS01000005_gene5503	1.033e-86	290.0	COG0852@1|root,COG0852@2|Bacteria,2GNVP@201174|Actinobacteria,4DBTZ@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoC2	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TLS2_k127_669434_8	263358.VAB18032_01355	2.098e-173	547.0	COG1005@1|root,COG1005@2|Bacteria,2GN3R@201174|Actinobacteria,4DB5M@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH2	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS2_k127_669434_23	263358.VAB18032_01345	1.293e-67	237.0	COG4636@1|root,COG4636@2|Bacteria,2I8SU@201174|Actinobacteria,4DE9R@85008|Micromonosporales	201174|Actinobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS2_k127_669434_17	263358.VAB18032_01340	3.017e-94	315.0	COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria,4DB0N@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI2	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
TLS2_k127_669434_24	369723.Strop_0401	1.16e-66	237.0	COG0839@1|root,COG0839@2|Bacteria,2GJB7@201174|Actinobacteria,4DDEB@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ2	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS2_k127_669434_35	644283.Micau_5561	1.22e-37	148.0	COG0713@1|root,COG0713@2|Bacteria,2I1AD@201174|Actinobacteria,4DF7U@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS2_k127_669434_4	356851.JOAN01000013_gene5725	2.424e-218	696.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4D9JY@85008|Micromonosporales	201174|Actinobacteria	CP	NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL2	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TLS2_k127_669434_3	219305.MCAG_02137	1.002e-218	691.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4DB40@85008|Micromonosporales	201174|Actinobacteria	C	proton-translocating NADH-quinone oxidoreductase, chain M	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_669434_27	369723.Strop_0405	4.727e-58	209.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4D93Y@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN2	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_6798959_13	1123023.JIAI01000021_gene2347	5.062e-70	248.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS2_k127_6798959_15	1172180.KB911793_gene3623	2.256e-61	217.0	COG0346@1|root,COG0346@2|Bacteria,2IM0I@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,Glyoxalase_4
TLS2_k127_6798959_0	1121926.AXWO01000001_gene3514	0.0	1670.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,2GKX9@201174|Actinobacteria,4EY34@85014|Glycomycetales	201174|Actinobacteria	F	Class II vitamin B12-dependent ribonucleotide reductase	nrdJ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
TLS2_k127_6798959_10	263358.VAB18032_12395	1.424e-77	265.0	COG1327@1|root,COG1327@2|Bacteria,2IHU9@201174|Actinobacteria,4DD07@85008|Micromonosporales	201174|Actinobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
TLS2_k127_6798959_17	33876.JNXY01000033_gene2147	9.384e-16	81.0	COG1388@1|root,COG1388@2|Bacteria,2GWI9@201174|Actinobacteria,4DGP3@85008|Micromonosporales	201174|Actinobacteria	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
TLS2_k127_6798959_8	1136417.AZWE01000037_gene1098	5.499e-110	362.0	COG1974@1|root,COG1974@2|Bacteria,2GMBN@201174|Actinobacteria,4D8KV@85008|Micromonosporales	201174|Actinobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
TLS2_k127_6798959_11	1150864.MILUP08_41647	1.827e-76	279.0	COG3386@1|root,COG3386@2|Bacteria,2GNAZ@201174|Actinobacteria,4DBY1@85008|Micromonosporales	201174|Actinobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6798959_2	1136417.AZWE01000037_gene1100	2.824e-217	683.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4D8FD@85008|Micromonosporales	201174|Actinobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TLS2_k127_6798959_4	65497.JODV01000014_gene3370	1.678e-207	661.0	COG1292@1|root,COG1292@2|Bacteria,2GJX0@201174|Actinobacteria,4DXDK@85010|Pseudonocardiales	201174|Actinobacteria	U	Belongs to the BCCT transporter (TC 2.A.15) family	-	-	-	ko:K02168	-	-	-	-	ko00000,ko02000	2.A.15.1.3,2.A.15.1.4	-	-	BCCT
TLS2_k127_6798959_9	369723.Strop_1446	2.657e-89	304.0	COG0253@1|root,COG0253@2|Bacteria,2GKUD@201174|Actinobacteria,4DB03@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
TLS2_k127_6798959_7	391037.Sare_1403	2.613e-128	416.0	COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria,4D8F0@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
TLS2_k127_6798959_6	1150864.MILUP08_41641	8.464e-169	540.0	COG1196@1|root,COG1196@2|Bacteria,2GJBD@201174|Actinobacteria,4D8F1@85008|Micromonosporales	201174|Actinobacteria	D	Domain of Unknown Function (DUF349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF349
TLS2_k127_6798959_1	1150864.MILUP08_41638	5.33e-254	792.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4D8II@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TLS2_k127_6798959_3	35754.JNYJ01000005_gene5528	1.648e-211	671.0	COG1418@1|root,COG1418@2|Bacteria,2I9DW@201174|Actinobacteria,4D9SR@85008|Micromonosporales	201174|Actinobacteria	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
TLS2_k127_6798959_14	644283.Micau_1534	1.107e-63	227.0	COG2137@1|root,COG2137@2|Bacteria,2GMRF@201174|Actinobacteria,4DD5X@85008|Micromonosporales	201174|Actinobacteria	S	Modulates RecA activity	recX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
TLS2_k127_6798959_5	134676.ACPL_7172	4.198e-196	619.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4DAV3@85008|Micromonosporales	201174|Actinobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TLS2_k127_6798959_16	644283.Micau_1532	2.608e-21	94.0	2EFU9@1|root,339KE@2|Bacteria,2HUPJ@201174|Actinobacteria,4DFPP@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3046)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3046
TLS2_k127_6798959_12	356851.JOAN01000012_gene5125	3.745e-75	259.0	COG0477@1|root,COG0477@2|Bacteria,2IIAH@201174|Actinobacteria,4D9T1@85008|Micromonosporales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_6799367_4	35754.JNYJ01000023_gene8321	2.552e-136	460.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4D9E2@85008|Micromonosporales	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,HTH_31,NB-ARC,TPR_10,TPR_12,TPR_8,Trans_reg_C
TLS2_k127_6799367_0	356851.JOAN01000015_gene2620	0.0	1184.0	COG1131@1|root,COG2936@1|root,COG1131@2|Bacteria,COG2936@2|Bacteria,2GN8P@201174|Actinobacteria,4DA34@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,PepX_C,Peptidase_S15
TLS2_k127_6799367_5	263358.VAB18032_02315	7.875e-117	384.0	COG1277@1|root,COG1277@2|Bacteria,2GP6D@201174|Actinobacteria,4D9F6@85008|Micromonosporales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
TLS2_k127_6799367_2	219305.MCAG_02318	3.759e-226	705.0	COG0498@1|root,COG0498@2|Bacteria,2GNM0@201174|Actinobacteria,4D967@85008|Micromonosporales	201174|Actinobacteria	E	Threonine synthase	thrC3	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_6799367_11	1121946.AUAX01000024_gene7564	2.212e-59	217.0	COG0741@1|root,COG0741@2|Bacteria,2II77@201174|Actinobacteria,4DDH7@85008|Micromonosporales	201174|Actinobacteria	M	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TLS2_k127_6799367_16	298654.FraEuI1c_3899	4.85e-28	118.0	2DSDZ@1|root,33FQR@2|Bacteria	2|Bacteria	S	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
TLS2_k127_6799367_10	1123504.JQKD01000012_gene1238	1.399e-61	214.0	COG1848@1|root,COG1848@2|Bacteria,1RK9K@1224|Proteobacteria	1224|Proteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_6799367_12	106370.Francci3_3381	1.045e-56	202.0	COG0720@1|root,COG0720@2|Bacteria,2IJ3A@201174|Actinobacteria	201174|Actinobacteria	H	synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
TLS2_k127_6799367_8	1136417.AZWE01000020_gene4107	2.466e-97	324.0	COG0603@1|root,COG0603@2|Bacteria,2I8NZ@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
TLS2_k127_6799367_14	1313172.YM304_11170	2.918e-38	147.0	COG0780@1|root,COG0780@2|Bacteria,2GS82@201174|Actinobacteria,4CNEJ@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
TLS2_k127_6799367_13	1463857.JOFZ01000001_gene5424	9.652e-54	198.0	COG0313@1|root,COG0313@2|Bacteria,2GJ9Q@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
TLS2_k127_6799367_9	1382306.JNIM01000001_gene1062	1.477e-85	296.0	COG0343@1|root,COG0343@2|Bacteria,2G87H@200795|Chloroflexi	200795|Chloroflexi	J	TIGRFAM tRNA-guanine transglycosylase, various specificities	-	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
TLS2_k127_6799367_7	1463926.JOCA01000016_gene602	3.018e-98	325.0	COG0602@1|root,COG0602@2|Bacteria,2I9R3@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
TLS2_k127_6799367_6	219305.MCAG_02317	3.687e-101	341.0	COG3153@1|root,COG3153@2|Bacteria,2I3ZT@201174|Actinobacteria,4D8JD@85008|Micromonosporales	201174|Actinobacteria	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_6799367_1	1150864.MILUP08_46585	1.013e-262	820.0	COG1012@1|root,COG1012@2|Bacteria,2GNJJ@201174|Actinobacteria,4DA95@85008|Micromonosporales	201174|Actinobacteria	C	phenylacetic acid degradation protein paaN	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_6799367_15	356851.JOAN01000015_gene2630	1.057e-33	130.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria,4DESV@85008|Micromonosporales	201174|Actinobacteria	K	'Cold-shock' DNA-binding domain	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_6799367_17	420662.Mpe_A1486	5.745e-05	53.0	COG4249@1|root,COG4249@2|Bacteria,1R45G@1224|Proteobacteria,2WEWV@28216|Betaproteobacteria,1KJ4W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
TLS2_k127_6799367_3	1150864.MILUP08_46579	6.029e-219	683.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4D901@85008|Micromonosporales	201174|Actinobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL1	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS2_k127_6839734_8	1464048.JNZS01000011_gene4965	5.99e-66	232.0	COG0629@1|root,COG0629@2|Bacteria,2GQIQ@201174|Actinobacteria,4DD88@85008|Micromonosporales	201174|Actinobacteria	L	Single-stranded DNA-binding protein	ssb2	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_6839734_4	644283.Micau_3332	7.844e-100	331.0	COG0454@1|root,COG0456@2|Bacteria,2GK76@201174|Actinobacteria,4DDIG@85008|Micromonosporales	201174|Actinobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_6839734_3	219305.MCAG_01643	2.913e-118	392.0	COG2267@1|root,COG2267@2|Bacteria,2GIVB@201174|Actinobacteria,4D8GX@85008|Micromonosporales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TLS2_k127_6839734_13	35754.JNYJ01000007_gene2954	3.966e-41	169.0	COG4848@1|root,COG4848@2|Bacteria,2ISI7@201174|Actinobacteria,4DEVW@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the UPF0354 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1444
TLS2_k127_6839734_7	1120950.KB892751_gene6740	8.811e-67	238.0	2CHE3@1|root,31B2D@2|Bacteria,2IEQU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6839734_16	356851.JOAN01000014_gene2009	7.5e-09	64.0	2AY9K@1|root,31QBZ@2|Bacteria,2IRWE@201174|Actinobacteria,4DFAN@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6839734_15	1121946.AUAX01000025_gene6399	1.528e-32	142.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	ko:K03749,ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	FG-GAP_2,SPOR
TLS2_k127_6839734_11	1121946.AUAX01000024_gene7656	9.094e-45	171.0	COG4385@1|root,COG4385@2|Bacteria,2IJ99@201174|Actinobacteria,4DDK1@85008|Micromonosporales	201174|Actinobacteria	S	Phage tail protein (Tail_P2_I)	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
TLS2_k127_6839734_0	644283.Micau_3534	0.0	1094.0	COG3299@1|root,COG3299@2|Bacteria,2GM5C@201174|Actinobacteria,4DC0A@85008|Micromonosporales	201174|Actinobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J,LysM
TLS2_k127_6839734_10	644283.Micau_3533	1.831e-45	168.0	COG3628@1|root,COG3628@2|Bacteria,2IFJ6@201174|Actinobacteria,4DEYN@85008|Micromonosporales	201174|Actinobacteria	S	Phage baseplate assembly protein W	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
TLS2_k127_6839734_12	1120950.KB892751_gene6746	1.149e-41	156.0	2E7P5@1|root,3324R@2|Bacteria,2ITER@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6839734_2	356851.JOAN01000014_gene2015	1.957e-149	489.0	COG3501@1|root,COG3501@2|Bacteria,2GP13@201174|Actinobacteria,4DC3F@85008|Micromonosporales	201174|Actinobacteria	S	Rhs element Vgr protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
TLS2_k127_6839734_5	1150864.MILUP08_43898	1.173e-94	316.0	COG1652@1|root,COG1652@2|Bacteria,2I92Z@201174|Actinobacteria,4DBGP@85008|Micromonosporales	201174|Actinobacteria	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
TLS2_k127_6839734_9	1349820.M707_12970	2.165e-55	198.0	2BEKE@1|root,328BU@2|Bacteria,2HTSJ@201174|Actinobacteria,1WC9H@1268|Micrococcaceae	201174|Actinobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
TLS2_k127_6839734_1	1120950.KB892751_gene6751	7.694e-182	576.0	COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria,4DQGK@85009|Propionibacteriales	201174|Actinobacteria	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
TLS2_k127_6839734_14	1120950.KB892751_gene6752	7.328e-38	153.0	2EJXK@1|root,33DN8@2|Bacteria,2IIWK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6839734_6	263358.VAB18032_20125	2.573e-70	244.0	COG3409@1|root,COG3409@2|Bacteria,2IM37@201174|Actinobacteria,4DDYX@85008|Micromonosporales	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6866683_26	356851.JOAN01000001_gene3764	1.986e-176	574.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,4D94K@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,PsbP
TLS2_k127_6866683_15	1120949.KB903306_gene7314	1.281e-228	720.0	COG1109@1|root,COG1109@2|Bacteria,2GJ3Q@201174|Actinobacteria,4D9IA@85008|Micromonosporales	201174|Actinobacteria	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	pmmB	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_6866683_84	512565.AMIS_74320	4.374e-45	173.0	COG0741@1|root,COG0741@2|Bacteria,2GM11@201174|Actinobacteria,4DD6V@85008|Micromonosporales	201174|Actinobacteria	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TLS2_k127_6866683_54	219305.MCAG_03319	3.349e-107	355.0	COG0637@1|root,COG0637@2|Bacteria,2I2IT@201174|Actinobacteria,4D9YP@85008|Micromonosporales	201174|Actinobacteria	S	Beta-phosphoglucomutase family hydrolase	-	GO:0003674,GO:0003824,GO:0008801,GO:0016853,GO:0016866,GO:0016868	-	-	-	-	-	-	-	-	-	-	HAD_2,Hydrolase
TLS2_k127_6866683_1	649831.L083_0546	0.0	1223.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4DBKN@85008|Micromonosporales	201174|Actinobacteria	G	hydrolase family 65	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
TLS2_k127_6866683_57	390989.JOEG01000003_gene4626	1.43e-102	336.0	COG0035@1|root,COG0035@2|Bacteria,2GPJE@201174|Actinobacteria,4DBBE@85008|Micromonosporales	201174|Actinobacteria	F	uracil phosphoribosyltransferase	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
TLS2_k127_6866683_35	35754.JNYJ01000007_gene2726	2.614e-146	470.0	COG0274@1|root,COG0274@2|Bacteria,2GJIR@201174|Actinobacteria,4DADZ@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS2_k127_6866683_9	219305.MCAG_03594	2.085e-274	848.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4D9YX@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_6866683_43	1464048.JNZS01000004_gene1337	2.669e-120	394.0	COG1012@1|root,COG1012@2|Bacteria,2GKSN@201174|Actinobacteria,4DAUS@85008|Micromonosporales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_6866683_67	1869.MB27_40345	2.464e-83	287.0	28NCS@1|root,2ZBFQ@2|Bacteria,2GNHS@201174|Actinobacteria,4D97Z@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6866683_37	644283.Micau_0793	9.682e-141	478.0	COG2972@1|root,COG2972@2|Bacteria,2I63K@201174|Actinobacteria,4DMRX@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6866683_58	644283.Micau_0791	1.808e-102	337.0	COG2229@1|root,COG2229@2|Bacteria,2GJIT@201174|Actinobacteria,4D97B@85008|Micromonosporales	201174|Actinobacteria	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
TLS2_k127_6866683_78	1121272.KB903293_gene7090	1.458e-52	187.0	COG1846@1|root,COG1846@2|Bacteria,2GQ8U@201174|Actinobacteria,4DDGF@85008|Micromonosporales	201174|Actinobacteria	K	Protein of unknown function (DUF742)	-	-	-	-	-	-	-	-	-	-	-	-	DUF742
TLS2_k127_6866683_72	33876.JNXY01000026_gene3518	3.623e-71	247.0	COG2018@1|root,COG2018@2|Bacteria,2IFB7@201174|Actinobacteria,4DD3M@85008|Micromonosporales	201174|Actinobacteria	S	Roadblock lc7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
TLS2_k127_6866683_10	263358.VAB18032_08655	9.324e-274	880.0	COG0642@1|root,COG2205@2|Bacteria,2I2WT@201174|Actinobacteria,4DBAY@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,NIT
TLS2_k127_6866683_23	1121946.AUAX01000005_gene5370	2.742e-184	584.0	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria,4DA9H@85008|Micromonosporales	201174|Actinobacteria	F	adenosine deaminase	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3313c	A_deaminase
TLS2_k127_6866683_71	644283.Micau_0781	7.255e-76	265.0	COG0500@1|root,COG2226@2|Bacteria,2HCAN@201174|Actinobacteria,4DC3Z@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase	rrmA	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008989,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052912,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.187	ko:K00563	-	-	R07233	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_6866683_61	134676.ACPL_7766	4.64e-96	319.0	2ECS8@1|root,336PU@2|Bacteria,2GK3S@201174|Actinobacteria,4D9X1@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4272)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4272
TLS2_k127_6866683_21	219305.MCAG_03574	2.843e-192	608.0	COG0213@1|root,COG0213@2|Bacteria,2GJH5@201174|Actinobacteria,4D8U4@85008|Micromonosporales	201174|Actinobacteria	F	phosphorylase	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
TLS2_k127_6866683_80	1246995.AFR_39570	1.42e-50	187.0	COG0295@1|root,COG0295@2|Bacteria,2IHP7@201174|Actinobacteria,4DBEW@85008|Micromonosporales	201174|Actinobacteria	F	cytidine deaminase	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
TLS2_k127_6866683_34	649831.L083_7524	3.966e-150	486.0	COG1079@1|root,COG1079@2|Bacteria,2GKMB@201174|Actinobacteria,4D974@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS2_k127_6866683_36	543632.JOJL01000037_gene6439	8.546e-145	473.0	COG4603@1|root,COG4603@2|Bacteria,2GKAZ@201174|Actinobacteria,4D9JU@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS2_k127_6866683_14	33876.JNXY01000026_gene3508	9.752e-231	724.0	COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria,4D8H3@85008|Micromonosporales	201174|Actinobacteria	S	ABC transporter related	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TLS2_k127_6866683_39	391037.Sare_0751	3.841e-133	435.0	COG1744@1|root,COG1744@2|Bacteria,2GMFS@201174|Actinobacteria,4DAD7@85008|Micromonosporales	201174|Actinobacteria	S	basic membrane	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
TLS2_k127_6866683_90	356851.JOAN01000001_gene3733	4.332e-37	145.0	2E4PN@1|root,32ZIA@2|Bacteria,2HUBJ@201174|Actinobacteria,4DE19@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6866683_19	1120949.KB903306_gene7547	1.967e-205	655.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4D8SF@85008|Micromonosporales	201174|Actinobacteria	G	alpha amylase, catalytic	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
TLS2_k127_6866683_101	1449347.JQLN01000004_gene7175	3.943e-10	71.0	COG0726@1|root,COG3345@1|root,COG0726@2|Bacteria,COG3345@2|Bacteria,2HRKN@201174|Actinobacteria,2M469@2063|Kitasatospora	201174|Actinobacteria	G	Glycosyl hydrolase family 9	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CelD_N,Glyco_hydro_9
TLS2_k127_6866683_75	219305.MCAG_03559	3.099e-66	236.0	COG1295@1|root,COG1295@2|Bacteria,2GN79@201174|Actinobacteria,4DBIG@85008|Micromonosporales	201174|Actinobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_6866683_25	1150864.MILUP08_40848	2.691e-179	566.0	COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria,4DAKB@85008|Micromonosporales	201174|Actinobacteria	J	Tryptophanyl-tRNA synthetase	trpS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS2_k127_6866683_98	1117647.M5M_18805	1.307e-16	84.0	2E5FW@1|root,3307K@2|Bacteria,1R3G8@1224|Proteobacteria,1T67F@1236|Gammaproteobacteria,1JA52@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
TLS2_k127_6866683_102	548479.HMPREF0573_10209	1.42e-07	59.0	2D089@1|root,32T81@2|Bacteria,2IHKJ@201174|Actinobacteria	201174|Actinobacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
TLS2_k127_6866683_3	1121272.KB903249_gene1627	0.0	1056.0	COG2267@1|root,COG4671@1|root,COG2267@2|Bacteria,COG4671@2|Bacteria,2HU5Q@201174|Actinobacteria,4DBMT@85008|Micromonosporales	201174|Actinobacteria	I	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Glyco_tran_28_C
TLS2_k127_6866683_46	1121272.KB903249_gene1628	9.321e-117	380.0	COG2020@1|root,COG2020@2|Bacteria,2GN9N@201174|Actinobacteria,4DDTM@85008|Micromonosporales	201174|Actinobacteria	O	NnrU protein	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU
TLS2_k127_6866683_65	1121272.KB903249_gene1629	4.393e-88	296.0	COG1309@1|root,COG1309@2|Bacteria,2IHGM@201174|Actinobacteria,4DD7T@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_6866683_103	1206101.AZXC01000042_gene3351	4.89e-05	46.0	COG1672@1|root,COG1672@2|Bacteria,2GMAZ@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Archaeal ATPase	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	AAA_16,DUF234
TLS2_k127_6866683_13	356851.JOAN01000001_gene3719	3.092e-244	758.0	COG2895@1|root,COG2895@2|Bacteria,2GJDX@201174|Actinobacteria,4DAUT@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysC	GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006793,GO:0006796,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:0071944,GO:1902494,GO:1902503,GO:1990234	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
TLS2_k127_6866683_30	1136417.AZWE01000010_gene2933	3.351e-158	514.0	COG0175@1|root,COG0175@2|Bacteria,2GN85@201174|Actinobacteria,4D8PY@85008|Micromonosporales	201174|Actinobacteria	EH	Phosphoadenosine phosphosulfate reductase family	cysD	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TLS2_k127_6866683_55	33876.JNXY01000026_gene3490	3.513e-104	345.0	COG1218@1|root,COG1218@2|Bacteria,2GMW7@201174|Actinobacteria,4DA74@85008|Micromonosporales	201174|Actinobacteria	P	Inositol monophosphatase	cysQ_1	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
TLS2_k127_6866683_64	644283.Micau_0755	1.916e-90	305.0	COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria,4DBHY@85008|Micromonosporales	201174|Actinobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
TLS2_k127_6866683_74	35754.JNYJ01000007_gene2690	9.716e-71	246.0	COG1825@1|root,COG1825@2|Bacteria,2GJPJ@201174|Actinobacteria,4DCS6@85008|Micromonosporales	201174|Actinobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
TLS2_k127_6866683_27	649831.L083_7545	2.884e-172	544.0	COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria,4D8W4@85008|Micromonosporales	201174|Actinobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
TLS2_k127_6866683_69	35754.JNYJ01000016_gene9360	1.518e-79	275.0	COG0725@1|root,COG0725@2|Bacteria,2GMPF@201174|Actinobacteria,4D9E9@85008|Micromonosporales	201174|Actinobacteria	P	Molybdenum ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
TLS2_k127_6866683_42	644283.Micau_3618	1.012e-122	401.0	COG4149@1|root,COG4149@2|Bacteria,2GJFB@201174|Actinobacteria,4DAIP@85008|Micromonosporales	201174|Actinobacteria	P	molybdate ABC transporter, inner membrane subunit	modB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,BPD_transp_1,TOBE
TLS2_k127_6866683_33	263358.VAB18032_06890	1.18e-150	501.0	COG3842@1|root,COG3842@2|Bacteria,2H2JF@201174|Actinobacteria,4DB8Q@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	modC	-	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
TLS2_k127_6866683_82	41431.PCC8801_0349	5.173e-48	183.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_6866683_47	41431.PCC8801_0348	3.378e-115	381.0	COG0528@1|root,COG0528@2|Bacteria	2|Bacteria	F	UMP kinase activity	mosB	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0030151,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914	2.7.4.22	ko:K00947,ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS2_k127_6866683_48	41431.PCC8801_0347	1.634e-114	375.0	COG0528@1|root,COG0528@2|Bacteria	2|Bacteria	F	UMP kinase activity	pyrH	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0030151,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914	2.7.4.22	ko:K00947,ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS2_k127_6866683_63	42256.RradSPS_3064	6.712e-92	312.0	COG0730@1|root,COG0730@2|Bacteria,2I9JV@201174|Actinobacteria	201174|Actinobacteria	S	membrane transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	TauE
TLS2_k127_6866683_49	1121946.AUAX01000005_gene5336	9.545e-111	360.0	COG1309@1|root,COG1309@2|Bacteria,2GMBW@201174|Actinobacteria,4DA16@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	icaR	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_6866683_28	356851.JOAN01000001_gene3712	6.774e-172	543.0	COG1398@1|root,COG1398@2|Bacteria,2GJJF@201174|Actinobacteria,4DA45@85008|Micromonosporales	201174|Actinobacteria	I	Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
TLS2_k127_6866683_22	219305.MCAG_03547	6.487e-186	596.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4D8CT@85008|Micromonosporales	201174|Actinobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
TLS2_k127_6866683_45	1120950.KB892743_gene3162	8.95e-117	384.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DTG1@85009|Propionibacteriales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6866683_53	1120950.KB892743_gene3161	2.02e-107	357.0	COG0842@1|root,COG0842@2|Bacteria,2GJGH@201174|Actinobacteria,4DTHC@85009|Propionibacteriales	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_6866683_85	219305.MCAG_03543	2.027e-43	166.0	2CAWP@1|root,32T0S@2|Bacteria,2IFTJ@201174|Actinobacteria,4DEYH@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4383
TLS2_k127_6866683_91	446470.Snas_0928	6.402e-36	142.0	2CAWP@1|root,32T0S@2|Bacteria,2IFTJ@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4383
TLS2_k127_6866683_59	66874.JOFS01000047_gene7645	3.105e-97	331.0	COG0477@1|root,COG2814@2|Bacteria,2GNUT@201174|Actinobacteria	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_6866683_2	284031.JNXD01000004_gene1335	0.0	1197.0	COG0318@1|root,COG1020@1|root,COG2141@1|root,COG3321@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG2141@2|Bacteria,COG3321@2|Bacteria,2GISR@201174|Actinobacteria	201174|Actinobacteria	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Bac_luciferase,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
TLS2_k127_6866683_0	66874.JOFS01000047_gene7647	0.0	1832.0	COG0001@1|root,COG1020@1|root,COG0001@2|Bacteria,COG1020@2|Bacteria,2GISR@201174|Actinobacteria	201174|Actinobacteria	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Aminotran_3,Bac_luciferase,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
TLS2_k127_6866683_76	1198452.Jab_2c07240	3.331e-62	235.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,473K1@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Linear gramicidin synthase subunit	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
TLS2_k127_6866683_12	649831.L083_5660	2.441e-254	816.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,4DAKK@85008|Micromonosporales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_6866683_41	1150864.MILUP08_40828	1.541e-124	412.0	COG1947@1|root,COG1947@2|Bacteria,2GKXD@201174|Actinobacteria,4D991@85008|Micromonosporales	201174|Actinobacteria	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0040007,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_6866683_51	219305.MCAG_03539	1.921e-109	366.0	COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria,4D8FZ@85008|Micromonosporales	201174|Actinobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TLS2_k127_6866683_50	1869.MB27_40145	1.591e-109	367.0	COG0084@1|root,COG0084@2|Bacteria,2GMJJ@201174|Actinobacteria,4DAVH@85008|Micromonosporales	201174|Actinobacteria	L	Hydrolase, TatD family	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
TLS2_k127_6866683_83	356851.JOAN01000015_gene2742	2.25e-45	176.0	COG3620@1|root,COG3620@2|Bacteria,2GVWB@201174|Actinobacteria,4DG5W@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
TLS2_k127_6866683_4	644283.Micau_0740	0.0	1009.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4DAQT@85008|Micromonosporales	201174|Actinobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
TLS2_k127_6866683_66	1121946.AUAX01000019_gene7769	1.063e-83	287.0	COG0300@1|root,COG0300@2|Bacteria,2GK2K@201174|Actinobacteria,4DMD1@85008|Micromonosporales	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_6866683_40	1435356.Y013_12475	4.909e-127	422.0	COG2141@1|root,COG2141@2|Bacteria,2GN4N@201174|Actinobacteria,4G8SR@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_6866683_97	1386089.N865_09815	1.668e-19	101.0	COG0313@1|root,COG0313@2|Bacteria,2GJ9Q@201174|Actinobacteria,4FF19@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
TLS2_k127_6866683_29	1136417.AZWE01000010_gene2916	1.528e-162	531.0	COG4346@1|root,COG4346@2|Bacteria,2GITT@201174|Actinobacteria,4D8UQ@85008|Micromonosporales	201174|Actinobacteria	O	C-terminal four TMM region of protein-O-mannosyltransferase	pmt	GO:0000030,GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006493,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0019538,GO:0034645,GO:0035268,GO:0035269,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	PMT,PMT_2,PMT_4TMC
TLS2_k127_6866683_95	219305.MCAG_04075	2.352e-22	102.0	COG0316@1|root,COG0316@2|Bacteria,2GR0Z@201174|Actinobacteria,4DFEV@85008|Micromonosporales	201174|Actinobacteria	S	HesB YadR YfhF-family protein	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_biosyn
TLS2_k127_6866683_79	649831.L083_7492	8.439e-52	206.0	2CIBE@1|root,32S7P@2|Bacteria,2IRU5@201174|Actinobacteria,4DC96@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6866683_8	644283.Micau_4194	1.312e-274	855.0	COG1249@1|root,COG1249@2|Bacteria,2I3I8@201174|Actinobacteria,4DBD6@85008|Micromonosporales	201174|Actinobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_6866683_88	369723.Strop_1657	4.01e-38	151.0	2D0CU@1|root,32T8C@2|Bacteria,2GNI4@201174|Actinobacteria,4DF6V@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6866683_77	443218.AS9A_2562	5.166e-61	216.0	2B3JS@1|root,31W90@2|Bacteria,2GP1G@201174|Actinobacteria,237AW@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6866683_93	1123024.AUII01000008_gene1771	2.294e-30	125.0	COG0723@1|root,COG0723@2|Bacteria,2I2JE@201174|Actinobacteria,4E6KK@85010|Pseudonocardiales	201174|Actinobacteria	C	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
TLS2_k127_6866683_94	1121946.AUAX01000016_gene4815	1.029e-22	102.0	2E388@1|root,32Y7X@2|Bacteria,2GQYZ@201174|Actinobacteria,4DG4J@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6866683_100	219305.MCAG_01703	1.477e-13	76.0	29242@1|root,2ZPP2@2|Bacteria,2IPAQ@201174|Actinobacteria,4DGD1@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6866683_6	882083.SacmaDRAFT_2957	3.7e-297	924.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4DXK7@85010|Pseudonocardiales	201174|Actinobacteria	P	E1-E2 ATPase	copB	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
TLS2_k127_6866683_86	1156919.QWC_00115	4.086e-41	168.0	COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,2VNCF@28216|Betaproteobacteria,3T2MP@506|Alcaligenaceae	28216|Betaproteobacteria	U	Involved in arsenical resistance. Thought to form the channel of an arsenite pump	arsB	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB
TLS2_k127_6866683_32	391037.Sare_0669	9.744e-153	490.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4DC4N@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	mcl1	-	4.1.3.34,5.4.99.63	ko:K01644,ko:K14447	ko00630,ko01120,ko01200,ko02020,map00630,map01120,map01200,map02020	M00373	R00362,R09292	RC00067,RC01118,RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_6866683_68	28444.JODQ01000007_gene5373	7.241e-80	270.0	COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4EK0J@85012|Streptosporangiales	201174|Actinobacteria	I	MaoC like domain	-	-	4.2.1.56	ko:K18290	ko00660,map00660	-	R02491	RC00730	ko00000,ko00001,ko01000	-	-	-	MaoC_dehydratas
TLS2_k127_6866683_20	512565.AMIS_57040	5.28e-199	625.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4D9H9@85008|Micromonosporales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_6866683_44	644283.Micau_0846	1.062e-119	394.0	COG1893@1|root,COG1893@2|Bacteria,2GP6K@201174|Actinobacteria,4D9HN@85008|Micromonosporales	201174|Actinobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
TLS2_k127_6866683_56	356851.JOAN01000008_gene2960	4.126e-103	342.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,4DB3Q@85008|Micromonosporales	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_6866683_70	644283.Micau_3439	6.861e-79	267.0	2C3A2@1|root,2ZZP3@2|Bacteria,2I9BD@201174|Actinobacteria,4DDD8@85008|Micromonosporales	201174|Actinobacteria	S	PFAM DoxX family protein	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
TLS2_k127_6866683_11	356851.JOAN01000008_gene2957	9.647e-256	811.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4DATZ@85008|Micromonosporales	201174|Actinobacteria	P	Heavy metal translocating P-type atpase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
TLS2_k127_6866683_7	483219.LILAB_26095	2.962e-296	936.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2YUAS@29|Myxococcales	28221|Deltaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS2_k127_6866683_16	263358.VAB18032_13100	1.187e-225	716.0	COG3850@1|root,COG3850@2|Bacteria,2GIWI@201174|Actinobacteria,4D91E@85008|Micromonosporales	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HATPase_c_2,HisKA_3
TLS2_k127_6866683_60	1464048.JNZS01000021_gene2689	5.031e-97	336.0	COG0778@1|root,COG0778@2|Bacteria,2I8P3@201174|Actinobacteria,4D9HC@85008|Micromonosporales	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_6866683_5	649831.L083_3448	9.634e-308	967.0	COG1042@1|root,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4DAH6@85008|Micromonosporales	201174|Actinobacteria	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
TLS2_k127_6866683_81	28444.JODQ01000008_gene1045	1.585e-48	183.0	COG3544@1|root,COG3544@2|Bacteria,2IKUE@201174|Actinobacteria,4EJD4@85012|Streptosporangiales	201174|Actinobacteria	S	Domain of unknown function (DUF4142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
TLS2_k127_6866683_17	263358.VAB18032_27406	2.166e-213	680.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4D971@85008|Micromonosporales	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_6866683_87	1869.MB27_18415	3.709e-38	158.0	COG0668@1|root,COG0668@2|Bacteria,2GJ51@201174|Actinobacteria,4D9AG@85008|Micromonosporales	201174|Actinobacteria	M	Mechanosensitive ion channel	mscS	-	-	-	-	-	-	-	-	-	-	-	MS_channel
TLS2_k127_6866683_92	929712.KI912613_gene3413	1.321e-31	133.0	2A3TI@1|root,30SBF@2|Bacteria,2HRMB@201174|Actinobacteria,4CTP5@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6866683_62	1121272.KB903289_gene4177	3.882e-95	318.0	COG1834@1|root,COG1834@2|Bacteria,2GNTN@201174|Actinobacteria	201174|Actinobacteria	E	amidinotransferase	ddaH	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
TLS2_k127_6866683_18	479432.Sros_4205	1.23e-211	691.0	COG2909@1|root,COG2909@2|Bacteria,2I6NJ@201174|Actinobacteria,4EMCM@85012|Streptosporangiales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_6866683_73	1193181.BN10_130039	6.235e-71	250.0	COG1893@1|root,COG1893@2|Bacteria	2|Bacteria	H	2-dehydropantoate 2-reductase activity	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA
TLS2_k127_6866683_52	1122182.KB903836_gene4789	1.819e-107	358.0	COG2239@1|root,COG2239@2|Bacteria,2I9TV@201174|Actinobacteria,4DH3P@85008|Micromonosporales	201174|Actinobacteria	P	Divalent cation transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE
TLS2_k127_6866683_31	1121272.KB903290_gene4611	1.64e-153	490.0	COG1262@1|root,COG1262@2|Bacteria,2GK9Q@201174|Actinobacteria,4D8VN@85008|Micromonosporales	201174|Actinobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TLS2_k127_6866683_96	1121946.AUAX01000016_gene4709	4.848e-21	99.0	29F3Q@1|root,3021G@2|Bacteria,2HDYA@201174|Actinobacteria,4DKNK@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6866683_38	1304865.JAGF01000001_gene1801	1.047e-135	443.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4F0VG@85016|Cellulomonadaceae	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_6866683_24	1304865.JAGF01000001_gene1800	1.709e-180	580.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4F1PH@85016|Cellulomonadaceae	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_6866683_89	518766.Rmar_2366	1.246e-37	162.0	COG1574@1|root,COG1574@2|Bacteria,4NFMV@976|Bacteroidetes,1FIKX@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_6874892_9	665577.JH993789_gene6297	9.597e-26	111.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_6874892_0	219305.MCAG_03143	4.45e-200	628.0	COG0031@1|root,COG0031@2|Bacteria,2GNE4@201174|Actinobacteria,4D8D3@85008|Micromonosporales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_6874892_3	391037.Sare_0680	6.027e-83	282.0	COG3428@1|root,COG3428@2|Bacteria,2IA1C@201174|Actinobacteria,4DAKZ@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
TLS2_k127_6874892_1	134676.ACPL_5886	9.969e-168	567.0	COG1388@1|root,COG1652@1|root,COG1388@2|Bacteria,COG1652@2|Bacteria,2I8YV@201174|Actinobacteria,4DAGE@85008|Micromonosporales	201174|Actinobacteria	M	PFAM Peptidoglycan-binding LysM	-	-	-	-	-	-	-	-	-	-	-	-	LysM
TLS2_k127_6874892_11	68223.JNZY01000038_gene4566	2.274e-20	101.0	2E4ST@1|root,32ZM5@2|Bacteria,2GSCH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Tad
TLS2_k127_6874892_8	1464048.JNZS01000015_gene3707	2.591e-28	120.0	COG4961@1|root,COG4961@2|Bacteria,2GRCJ@201174|Actinobacteria,4DF1R@85008|Micromonosporales	201174|Actinobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS2_k127_6874892_12	227882.SAV_189	1.938e-10	66.0	COG4961@1|root,COG4961@2|Bacteria,2I36X@201174|Actinobacteria	201174|Actinobacteria	U	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS2_k127_6874892_5	1136417.AZWE01000034_gene536	3.834e-65	235.0	COG4965@1|root,COG4965@2|Bacteria,2I2Z3@201174|Actinobacteria,4DB29@85008|Micromonosporales	201174|Actinobacteria	U	Type ii secretion system	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
TLS2_k127_6874892_4	219305.MCAG_03079	2.153e-74	263.0	COG4965@1|root,COG4965@2|Bacteria,2GN6E@201174|Actinobacteria,4D9WI@85008|Micromonosporales	201174|Actinobacteria	U	Type ii secretion system	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
TLS2_k127_6874892_2	1464048.JNZS01000015_gene3711	9.584e-139	456.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4DBIQ@85008|Micromonosporales	201174|Actinobacteria	U	type II secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS2_k127_6874892_6	33876.JNXY01000031_gene2971	1.03e-56	208.0	COG0455@1|root,COG0455@2|Bacteria,2HT5K@201174|Actinobacteria,4D9T2@85008|Micromonosporales	201174|Actinobacteria	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6874892_10	1380356.JNIK01000001_gene2274	8.513e-22	103.0	COG1261@1|root,COG1261@2|Bacteria,2IR93@201174|Actinobacteria,4ETJ2@85013|Frankiales	201174|Actinobacteria	NO	SAF	-	-	-	-	-	-	-	-	-	-	-	-	SAF
TLS2_k127_6874892_7	1157632.AQWQ01000003_gene2093	7.47e-44	175.0	2DVVA@1|root,32V07@2|Bacteria,2IHH0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6874892_14	436229.JOEH01000020_gene7893	0.0002179	51.0	293MI@1|root,2ZR3B@2|Bacteria,2ISY8@201174|Actinobacteria,2NJEJ@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6913982_1	369723.Strop_0216	7.276e-200	636.0	COG0747@1|root,COG0747@2|Bacteria,2GMAX@201174|Actinobacteria,4D8RF@85008|Micromonosporales	201174|Actinobacteria	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_6913982_2	219305.MCAG_02491	4.956e-111	364.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4D9MS@85008|Micromonosporales	201174|Actinobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
TLS2_k127_6913982_3	35754.JNYJ01000054_gene9770	7.418e-38	147.0	COG0718@1|root,COG0718@2|Bacteria,2IRC4@201174|Actinobacteria,4DE90@85008|Micromonosporales	201174|Actinobacteria	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
TLS2_k127_6913982_0	391037.Sare_0252	2.454e-235	752.0	COG2812@1|root,COG2812@2|Bacteria,2GJKA@201174|Actinobacteria,4DB0V@85008|Micromonosporales	201174|Actinobacteria	L	DNA polymerase III	dnaX	GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
TLS2_k127_6926969_0	106370.Francci3_1918	0.0	1317.0	COG0376@1|root,COG0376@2|Bacteria,2GJFP@201174|Actinobacteria,4ESBN@85013|Frankiales	201174|Actinobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
TLS2_k127_6926969_12	882083.SacmaDRAFT_2391	7.835e-70	248.0	COG0735@1|root,COG0735@2|Bacteria,2IFBR@201174|Actinobacteria,4E3M6@85010|Pseudonocardiales	201174|Actinobacteria	P	Belongs to the Fur family	furA	-	-	ko:K22297	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_6926969_17	1246448.ANAZ01000036_gene198	6.799e-21	94.0	2C1FX@1|root,3358G@2|Bacteria,2GS1S@201174|Actinobacteria,4EQC3@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6926969_3	35754.JNYJ01000036_gene3621	1.12e-190	617.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4DBM6@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS2_k127_6926969_7	1150864.MILUP08_41425	9.593e-142	461.0	COG1940@1|root,COG1940@2|Bacteria,2IB2E@201174|Actinobacteria,4D8WY@85008|Micromonosporales	201174|Actinobacteria	GK	ROK family	glcK	-	-	-	-	-	-	-	-	-	-	-	ROK
TLS2_k127_6926969_14	263358.VAB18032_05575	2.678e-54	202.0	COG1989@1|root,COG1989@2|Bacteria,2HU7A@201174|Actinobacteria,4DCGQ@85008|Micromonosporales	201174|Actinobacteria	NOU	Belongs to the peptidase A24 family	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	Peptidase_A24
TLS2_k127_6926969_15	263358.VAB18032_29186	8.557e-41	157.0	2EA32@1|root,33485@2|Bacteria,2IN6C@201174|Actinobacteria,4DEKJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6926969_16	33876.JNXY01000031_gene3026	1.013e-30	125.0	2E65S@1|root,330UF@2|Bacteria,2IMEQ@201174|Actinobacteria,4DERM@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF3817)	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF3817
TLS2_k127_6926969_13	33876.JNXY01000031_gene3024	2.228e-63	228.0	COG1396@1|root,COG1396@2|Bacteria,2GJBK@201174|Actinobacteria,4DEBF@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
TLS2_k127_6926969_6	1121272.KB903272_gene445	5.406e-143	467.0	COG0683@1|root,COG0683@2|Bacteria,2GMCF@201174|Actinobacteria,4D8YQ@85008|Micromonosporales	201174|Actinobacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
TLS2_k127_6926969_5	1121272.KB903272_gene444	5.351e-144	465.0	COG4177@1|root,COG4177@2|Bacteria,2GMGD@201174|Actinobacteria,4DEZ6@85008|Micromonosporales	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_6926969_11	1121272.KB903272_gene443	1.23e-106	353.0	COG0559@1|root,COG0559@2|Bacteria,2HDZ9@201174|Actinobacteria,4DH4D@85008|Micromonosporales	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_6926969_1	1121272.KB903272_gene442	1.064e-287	895.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4DA3R@85008|Micromonosporales	201174|Actinobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS2_k127_6926969_8	35754.JNYJ01000007_gene2928	4.185e-130	419.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4DDVG@85008|Micromonosporales	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_6926969_10	35754.JNYJ01000007_gene2927	1.35e-118	387.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4D9QU@85008|Micromonosporales	201174|Actinobacteria	E	COG0410 ABC-type branched-chain amino acid transport systems, ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_6926969_9	28042.GU90_00660	2.691e-127	416.0	COG3173@1|root,COG3173@2|Bacteria,2GJT0@201174|Actinobacteria,4DXPM@85010|Pseudonocardiales	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_6926969_2	103733.JNYO01000016_gene3378	2.443e-194	616.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4E03N@85010|Pseudonocardiales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE31	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_6926969_4	391037.Sare_3959	9.687e-190	595.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4D8W5@85008|Micromonosporales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	hrdD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_6947993_13	479435.Kfla_6833	1.568e-11	64.0	COG1960@1|root,COG1960@2|Bacteria,2GJIB@201174|Actinobacteria,4DP6T@85009|Propionibacteriales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase N terminal	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,AcylCoA_DH_N
TLS2_k127_6947993_2	263358.VAB18032_04965	1.319e-168	539.0	COG2208@1|root,COG2208@2|Bacteria,2GK3Y@201174|Actinobacteria,4D97T@85008|Micromonosporales	201174|Actinobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
TLS2_k127_6947993_7	1123024.AUII01000012_gene4246	2.013e-93	325.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_6947993_4	644283.Micau_0303	1.709e-150	485.0	2DBF7@1|root,2Z8X0@2|Bacteria,2I0F0@201174|Actinobacteria,4DBGG@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
TLS2_k127_6947993_10	1440053.JOEI01000006_gene2614	3.067e-47	175.0	2AY0M@1|root,33ZNP@2|Bacteria,2I85A@201174|Actinobacteria	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N,SHOCT
TLS2_k127_6947993_1	680198.SCAB_34181	2.95e-192	613.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	ko:K04753	-	-	-	-	ko00000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
TLS2_k127_6947993_15	1150864.MILUP08_42123	2.388e-05	49.0	COG2909@1|root,COG2909@2|Bacteria,2GM03@201174|Actinobacteria,4D9RB@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_22,GerE
TLS2_k127_6947993_8	1089546.AQUI01000002_gene4336	2.624e-63	229.0	COG1397@1|root,COG1397@2|Bacteria,2GNSG@201174|Actinobacteria,4092D@622450|Actinopolysporales	201174|Actinobacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
TLS2_k127_6947993_12	1906.SFRA_16770	9.271e-13	72.0	COG3462@1|root,COG3462@2|Bacteria,2GRGM@201174|Actinobacteria	201174|Actinobacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
TLS2_k127_6947993_5	1169161.KB897722_gene4375	1.629e-132	433.0	COG3288@1|root,COG3288@2|Bacteria,2I2FZ@201174|Actinobacteria	201174|Actinobacteria	C	NADP transhydrogenase	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TLS2_k127_6947993_11	446470.Snas_3850	6.241e-32	140.0	COG3288@1|root,COG3288@2|Bacteria,2IKR9@201174|Actinobacteria	201174|Actinobacteria	C	NADP transhydrogenase	pntAB	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
TLS2_k127_6947993_3	390989.JOEG01000013_gene2547	2.704e-167	544.0	COG1282@1|root,COG1282@2|Bacteria,2GNKB@201174|Actinobacteria,4DI9M@85008|Micromonosporales	201174|Actinobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
TLS2_k127_6947993_0	103733.JNYO01000033_gene7222	0.0	1263.0	COG0751@1|root,COG0752@1|root,COG0751@2|Bacteria,COG0752@2|Bacteria,2HFU4@201174|Actinobacteria,4E1S6@85010|Pseudonocardiales	201174|Actinobacteria	J	Glycyl-tRNA synthetase alpha subunit	glyS	-	6.1.1.14	ko:K01879,ko:K14164	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA-synt_2e,tRNA_synt_2f
TLS2_k127_6947993_9	263358.VAB18032_04890	4.282e-59	209.0	2BWWR@1|root,2ZG0F@2|Bacteria,2IJ2X@201174|Actinobacteria,4DDGM@85008|Micromonosporales	201174|Actinobacteria	S	pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_6947993_6	263358.VAB18032_04885	2.165e-110	358.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,4D8XU@85008|Micromonosporales	201174|Actinobacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
TLS2_k127_6992142_1	644283.Micau_4966	4.964e-204	660.0	COG1793@1|root,COG1793@2|Bacteria,2GJ2P@201174|Actinobacteria,4DA13@85008|Micromonosporales	201174|Actinobacteria	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
TLS2_k127_6992142_0	1150864.MILUP08_45770	4.657e-212	672.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4D8NU@85008|Micromonosporales	201174|Actinobacteria	E	Peptidase dimerisation domain	argE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_6992142_3	1463841.JOIR01000004_gene6318	1.593e-47	184.0	COG0537@1|root,COG0537@2|Bacteria,2HNIX@201174|Actinobacteria	201174|Actinobacteria	FG	adenosine 5'-monophosphoramidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6992142_2	35754.JNYJ01000007_gene2958	3.796e-163	529.0	COG0501@1|root,COG0501@2|Bacteria,2GKJQ@201174|Actinobacteria,4DBRM@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS2_k127_7041723_0	1121272.KB903249_gene2534	2.673e-224	699.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,4D8EK@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
TLS2_k127_7041723_2	644283.Micau_2343	5.724e-168	539.0	COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria,4D8F9@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TLS2_k127_7041723_7	1121272.KB903249_gene2532	3.793e-45	164.0	COG1758@1|root,COG1758@2|Bacteria,2IQHU@201174|Actinobacteria,4DF03@85008|Micromonosporales	201174|Actinobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
TLS2_k127_7041723_10	1485545.JQLW01000010_gene1670	1.596e-16	91.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria	1224|Proteobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193	Guanylate_kin
TLS2_k127_7041723_8	1121272.KB903249_gene2530	9.743e-45	164.0	COG0099@1|root,COG0099@2|Bacteria,2IKPU@201174|Actinobacteria,4DE0A@85008|Micromonosporales	201174|Actinobacteria	J	integration host factor	mihF	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7041723_5	1150864.MILUP08_42524	2.671e-114	374.0	COG0284@1|root,COG0284@2|Bacteria,2GKWK@201174|Actinobacteria,4D8VY@85008|Micromonosporales	201174|Actinobacteria	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
TLS2_k127_7041723_1	208444.JNYY01000008_gene8792	1.377e-210	666.0	COG0161@1|root,COG0161@2|Bacteria,2I2DN@201174|Actinobacteria,4DZ9R@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	GO:0003674,GO:0003824,GO:0004015,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_7041723_3	356851.JOAN01000007_gene4152	5.454e-163	520.0	COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4D96V@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.3.5.2,1.3.98.1	ko:K00226,ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01867,R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TLS2_k127_7041723_4	35754.JNYJ01000013_gene1118	3.546e-135	437.0	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria,4DA8Q@85008|Micromonosporales	201174|Actinobacteria	F	adenosine deaminase	-	-	3.5.4.4,3.5.4.40	ko:K01488,ko:K18286	ko00130,ko00230,ko01100,ko01110,ko05340,map00130,map00230,map01100,map01110,map05340	-	R01560,R02556,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
TLS2_k127_7041723_6	1114959.SZMC14600_21883	1.471e-69	237.0	COG2356@1|root,COG2356@2|Bacteria,2GJ38@201174|Actinobacteria,4E0W9@85010|Pseudonocardiales	201174|Actinobacteria	L	Protein of unknown function (DUF1524)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1524
TLS2_k127_7111514_15	246196.MSMEI_3845	1.424e-58	214.0	COG1544@1|root,COG1544@2|Bacteria,2IB6N@201174|Actinobacteria,236GW@1762|Mycobacteriaceae	201174|Actinobacteria	J	Ribosome-associated protein Y (PSrp-1)	-	-	-	-	-	-	-	-	-	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
TLS2_k127_7111514_4	391037.Sare_3142	1.791e-154	501.0	COG2223@1|root,COG2223@2|Bacteria,2GJ1I@201174|Actinobacteria,4DAZE@85008|Micromonosporales	201174|Actinobacteria	P	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
TLS2_k127_7111514_6	644283.Micau_3965	1.399e-101	340.0	COG2181@1|root,COG2181@2|Bacteria,2GJVI@201174|Actinobacteria,4DA4Z@85008|Micromonosporales	201174|Actinobacteria	C	Nitrate reductase gamma subunit	-	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
TLS2_k127_7111514_14	1121272.KB903276_gene6987	1.031e-58	223.0	COG2180@1|root,COG2180@2|Bacteria,2IAQV@201174|Actinobacteria,4DDWN@85008|Micromonosporales	201174|Actinobacteria	C	Nitrate reductase delta subunit	-	-	-	ko:K00373	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Nitrate_red_del
TLS2_k127_7111514_2	644283.Micau_3963	4.007e-317	975.0	COG1140@1|root,COG1140@2|Bacteria,2GJ8P@201174|Actinobacteria,4DABG@85008|Micromonosporales	201174|Actinobacteria	C	TIGRFAM nitrate reductase, beta subunit	narH	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
TLS2_k127_7111514_0	644283.Micau_3962	0.0	2122.0	COG5013@1|root,COG5013@2|Bacteria,2GKZU@201174|Actinobacteria,4DBD9@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding
TLS2_k127_7111514_10	1121272.KB903249_gene1466	5.853e-75	273.0	COG0288@1|root,COG0288@2|Bacteria,2GT5H@201174|Actinobacteria,4DDKJ@85008|Micromonosporales	201174|Actinobacteria	P	Reversible hydration of carbon dioxide	cynT	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008270,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS2_k127_7111514_3	928724.SacglDRAFT_03382	5.765e-174	550.0	COG0435@1|root,COG0435@2|Bacteria,2GIXK@201174|Actinobacteria,4DXH5@85010|Pseudonocardiales	201174|Actinobacteria	O	Glutathione S-transferase	yqjG	-	1.8.5.7	ko:K07393	-	-	-	-	ko00000,ko01000	-	-	-	GST_C_2,GST_N_2
TLS2_k127_7111514_21	326424.FRAAL2705	3.877e-14	74.0	COG0708@1|root,COG0708@2|Bacteria,2IDNC@201174|Actinobacteria	201174|Actinobacteria	L	Exodeoxyribonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_7111514_16	267608.RSc1499	1.921e-58	213.0	COG3751@1|root,COG3751@2|Bacteria,1N2TX@1224|Proteobacteria	1224|Proteobacteria	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_3
TLS2_k127_7111514_5	1122611.KB903939_gene305	5.802e-140	456.0	COG0457@1|root,COG0457@2|Bacteria,2IFW2@201174|Actinobacteria	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7111514_7	267608.RSc1497	3.21e-84	286.0	COG0457@1|root,COG0457@2|Bacteria,1RCUA@1224|Proteobacteria	1224|Proteobacteria	S	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
TLS2_k127_7111514_9	134676.ACPL_4304	1.672e-80	282.0	COG4974@1|root,COG4974@2|Bacteria,2ID5W@201174|Actinobacteria,4DAAC@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_7111514_18	1136417.AZWE01000066_gene1134	1.218e-29	131.0	2BG3I@1|root,32A01@2|Bacteria,2GPF5@201174|Actinobacteria,4DICB@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7111514_20	512565.AMIS_30930	2.364e-16	81.0	COG0669@1|root,COG0669@2|Bacteria,2H5TT@201174|Actinobacteria,4DJEI@85008|Micromonosporales	201174|Actinobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	-	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_7111514_1	1394178.AWOO02000003_gene2762	0.0	1411.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4EFUP@85012|Streptosporangiales	201174|Actinobacteria	L	ABC transporter	uvrA2	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_7111514_12	471852.Tcur_0010	1.443e-64	230.0	COG0346@1|root,COG0346@2|Bacteria,2IHYP@201174|Actinobacteria,4EJBI@85012|Streptosporangiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_7111514_11	66869.JNXG01000001_gene4040	9.902e-71	255.0	COG2207@1|root,COG2207@2|Bacteria,2IFDE@201174|Actinobacteria,41AHG@629295|Streptomyces griseus group	201174|Actinobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS2_k127_7111514_13	1150864.MILUP08_45401	2.54e-60	223.0	COG0496@1|root,COG0496@2|Bacteria,2IFAX@201174|Actinobacteria,4DA9V@85008|Micromonosporales	201174|Actinobacteria	S	Survival protein SurE	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
TLS2_k127_7111514_8	1150864.MILUP08_43305	8.655e-81	278.0	COG0572@1|root,COG0572@2|Bacteria,2GMCP@201174|Actinobacteria,4DDB6@85008|Micromonosporales	201174|Actinobacteria	F	uridine kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7142313_22	1246445.ANAY01000026_gene2579	7.037e-11	64.0	COG0654@1|root,COG0654@2|Bacteria,2GKIN@201174|Actinobacteria,4EHV7@85012|Streptosporangiales	201174|Actinobacteria	CH	FAD binding domain	-	-	1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
TLS2_k127_7142313_13	33876.JNXY01000018_gene7791	3.898e-102	339.0	COG4106@1|root,COG4106@2|Bacteria,2GK0K@201174|Actinobacteria,4DBTF@85008|Micromonosporales	201174|Actinobacteria	S	Methyltransferase domain	metZ	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_7142313_8	263358.VAB18032_23030	5.695e-120	393.0	COG0583@1|root,COG0583@2|Bacteria,2I9RK@201174|Actinobacteria,4D8EQ@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_7142313_15	1236902.ANAS01000001_gene1881	2.291e-91	317.0	COG3064@1|root,COG3064@2|Bacteria,2I349@201174|Actinobacteria,4ER3Q@85012|Streptosporangiales	201174|Actinobacteria	M	Alpha-lytic protease prodomain	-	-	-	-	-	-	-	-	-	-	-	-	Pro_Al_protease,Trypsin
TLS2_k127_7142313_11	35754.JNYJ01000064_gene1407	1.028e-109	379.0	COG1716@1|root,COG1716@2|Bacteria,2I4MV@201174|Actinobacteria,4D8EZ@85008|Micromonosporales	201174|Actinobacteria	T	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7142313_1	644283.Micau_4179	1.696e-182	580.0	COG1653@1|root,COG1653@2|Bacteria,2GM4E@201174|Actinobacteria,4DBVN@85008|Micromonosporales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	lpqY	GO:0006810,GO:0008150,GO:0008643,GO:0009405,GO:0015766,GO:0015771,GO:0015772,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051179,GO:0051234,GO:0051704,GO:0071702	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_7142313_5	1246995.AFR_11400	7.42e-142	477.0	COG1175@1|root,COG1175@2|Bacteria,2GM6N@201174|Actinobacteria,4DAKV@85008|Micromonosporales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	sugA	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704	-	ko:K02025,ko:K10228	ko02010,map02010	M00200,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.5	-	iNJ661.Rv1236	BPD_transp_1
TLS2_k127_7142313_7	446462.Amir_0809	1.889e-128	434.0	COG0395@1|root,COG0395@2|Bacteria,2GKEE@201174|Actinobacteria,4E1QP@85010|Pseudonocardiales	201174|Actinobacteria	G	ABC-type sugar transport system, permease component	sugB	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_7142313_0	644283.Micau_4176	2.148e-189	597.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4D93R@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	sugC	GO:0006810,GO:0008150,GO:0008643,GO:0009405,GO:0015766,GO:0015771,GO:0015772,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051179,GO:0051234,GO:0051704,GO:0071702	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran
TLS2_k127_7142313_14	1242864.D187_009616	1.477e-95	330.0	COG5184@1|root,COG5184@2|Bacteria,1R504@1224|Proteobacteria,42QHC@68525|delta/epsilon subdivisions,2WKUI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	DZ	Alpha-tubulin suppressor and related RCC1 domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	RCC1
TLS2_k127_7142313_23	512565.AMIS_23120	4.384e-05	55.0	2BBEU@1|root,324Y3@2|Bacteria,2H9Y1@201174|Actinobacteria,4DKDC@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7142313_19	1121272.KB903293_gene7082	5.427e-51	186.0	COG1595@1|root,COG1595@2|Bacteria,2IRGN@201174|Actinobacteria,4DJ10@85008|Micromonosporales	201174|Actinobacteria	K	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_7142313_4	644283.Micau_1723	4.904e-146	480.0	COG5002@1|root,COG5002@2|Bacteria,2I2WW@201174|Actinobacteria,4DA6Z@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_7142313_10	512565.AMIS_49940	2.304e-112	368.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4DARZ@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	-	-	-	ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_7142313_12	649831.L083_4570	7.063e-106	355.0	COG2834@1|root,COG2834@2|Bacteria,2GKA2@201174|Actinobacteria,4D8U8@85008|Micromonosporales	201174|Actinobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092,MucB_RseB
TLS2_k127_7142313_6	1246995.AFR_20305	2.495e-133	433.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,4DB9P@85008|Micromonosporales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_7142313_16	1032480.MLP_11880	3.045e-90	305.0	COG1277@1|root,COG1277@2|Bacteria,2GP6D@201174|Actinobacteria,4DQVJ@85009|Propionibacteriales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
TLS2_k127_7142313_3	526225.Gobs_1786	1.198e-146	475.0	COG1168@1|root,COG1168@2|Bacteria,2GJFQ@201174|Actinobacteria,4ESK6@85013|Frankiales	201174|Actinobacteria	E	PFAM Aminotransferase class I and II	-	-	4.4.1.8	ko:K00842,ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_7142313_18	1120950.KB892796_gene2243	5.658e-79	269.0	COG1192@1|root,COG1192@2|Bacteria,2ICWE@201174|Actinobacteria,4DSPB@85009|Propionibacteriales	201174|Actinobacteria	D	VirC1 protein	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
TLS2_k127_7142313_21	471852.Tcur_1987	1.311e-26	112.0	2EP16@1|root,33GN1@2|Bacteria,2IHWQ@201174|Actinobacteria,4EKF3@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7142313_20	1150864.MILUP08_45958	6.402e-44	164.0	2BX7X@1|root,32RMD@2|Bacteria,2IKN7@201174|Actinobacteria,4DDYS@85008|Micromonosporales	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7142313_2	1120950.KB892773_gene1096	2.588e-163	524.0	COG4175@1|root,COG4175@2|Bacteria,2GJC0@201174|Actinobacteria,4DNKJ@85009|Propionibacteriales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	proV	-	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran,CBS
TLS2_k127_7142313_17	882083.SacmaDRAFT_3038	3.996e-85	294.0	COG4176@1|root,COG4176@2|Bacteria,2GKRF@201174|Actinobacteria,4DZ6P@85010|Pseudonocardiales	201174|Actinobacteria	E	ABC-type proline glycine betaine transport system, permease component	opuAB	-	-	ko:K02001,ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
TLS2_k127_7142313_9	882083.SacmaDRAFT_3037	1.194e-117	387.0	COG2113@1|root,COG2113@2|Bacteria,2I2IV@201174|Actinobacteria,4E0PR@85010|Pseudonocardiales	201174|Actinobacteria	E	ABC-type proline glycine betaine transport	opuAC	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
TLS2_k127_7234616_0	356851.JOAN01000007_gene4041	4.959e-178	565.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4D8TR@85008|Micromonosporales	201174|Actinobacteria	S	ATPase associated with various cellular activities	moxR1	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_7234616_2	35754.JNYJ01000035_gene3873	1.83e-129	428.0	COG1721@1|root,COG1721@2|Bacteria,2GKSJ@201174|Actinobacteria,4DAA9@85008|Micromonosporales	201174|Actinobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_7234616_1	1246995.AFR_11015	6.968e-132	428.0	COG2304@1|root,COG2304@2|Bacteria,2GNKP@201174|Actinobacteria,4D9TC@85008|Micromonosporales	201174|Actinobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
TLS2_k127_7234616_5	266264.Rmet_5187	4.384e-06	53.0	COG2911@1|root,COG3055@1|root,COG2911@2|Bacteria,COG3055@2|Bacteria,1MYQG@1224|Proteobacteria,2VX2F@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Kelch_1,Kelch_4,fn3
TLS2_k127_7234616_4	219305.MCAG_01029	4.276e-118	386.0	COG1028@1|root,COG1028@2|Bacteria,2GK6C@201174|Actinobacteria,4DAAN@85008|Micromonosporales	201174|Actinobacteria	IQ	reductase	fabG1	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0018454,GO:0019752,GO:0030497,GO:0032787,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046459,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0070402,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059,ko:K11610	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_7234616_3	1136417.AZWE01000019_gene4027	3.888e-126	420.0	COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria,4D93E@85008|Micromonosporales	201174|Actinobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	inhA	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030312,GO:0030497,GO:0031406,GO:0032787,GO:0033293,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208,ko:K11611	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_7308345_11	471853.Bcav_3740	2.374e-78	267.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria	201174|Actinobacteria	E	decarboxylase	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS2_k127_7308345_1	1136417.AZWE01000012_gene2477	1.445e-272	846.0	COG0488@1|root,COG0488@2|Bacteria,2GMUD@201174|Actinobacteria,4DAGQ@85008|Micromonosporales	201174|Actinobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_7308345_7	33876.JNXY01000033_gene2277	1.881e-139	469.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4D8UX@85008|Micromonosporales	201174|Actinobacteria	T	Signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,EAL,GGDEF,PAS,PAS_4,PAS_9
TLS2_k127_7308345_14	211114.JOEF01000019_gene580	1.453e-46	174.0	COG2203@1|root,COG2203@2|Bacteria,2I2RA@201174|Actinobacteria,4EDZR@85010|Pseudonocardiales	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF
TLS2_k127_7308345_10	1449976.KALB_1931	2.766e-101	341.0	COG3268@1|root,COG3268@2|Bacteria,2GNGH@201174|Actinobacteria,4DZQJ@85010|Pseudonocardiales	201174|Actinobacteria	S	Saccharopine dehydrogenase	-	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_NADP
TLS2_k127_7308345_8	263358.VAB18032_25610	6.085e-126	408.0	COG0613@1|root,COG0613@2|Bacteria,2GIZ5@201174|Actinobacteria,4D8HD@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3097)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3097
TLS2_k127_7308345_13	644283.Micau_1650	6.433e-48	188.0	COG4762@1|root,COG4762@2|Bacteria,2IQ4G@201174|Actinobacteria,4DFDJ@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF1990)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1990
TLS2_k127_7308345_17	28444.JODQ01000001_gene2418	3.182e-19	99.0	2E3I3@1|root,32YGJ@2|Bacteria,2GV2N@201174|Actinobacteria,4EPM9@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF3467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3467
TLS2_k127_7308345_3	35754.JNYJ01000054_gene9763	1.14e-190	599.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4D8RT@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_7308345_2	263358.VAB18032_03170	2.799e-218	683.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4DAGV@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the aspartokinase family	ask	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
TLS2_k127_7308345_15	263358.VAB18032_03175	6.716e-42	174.0	2C6IE@1|root,3429N@2|Bacteria,2II73@201174|Actinobacteria,4DDSJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7308345_0	219305.MCAG_02482	1.325e-304	941.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,4DBBT@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS2_k127_7308345_12	263358.VAB18032_03195	1.093e-63	232.0	COG2356@1|root,COG2356@2|Bacteria,2GJ38@201174|Actinobacteria,4DBS7@85008|Micromonosporales	201174|Actinobacteria	L	Protein of unknown function (DUF1524)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1524
TLS2_k127_7308345_16	512565.AMIS_78420	6.713e-30	120.0	2DS6C@1|root,33ERP@2|Bacteria,2GU4V@201174|Actinobacteria,4DEIW@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7308345_4	644283.Micau_5945	1.322e-185	585.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4DAQV@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS2_k127_7308345_5	1136417.AZWE01000029_gene211	5.237e-159	508.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4D9JJ@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	appD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_7308345_9	263358.VAB18032_03215	3.725e-123	403.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4DA73@85008|Micromonosporales	201174|Actinobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	appCC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_7308345_6	391037.Sare_0256	3.521e-148	475.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria,4DAAA@85008|Micromonosporales	201174|Actinobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	dppB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_7448287_0	263358.VAB18032_00355	1.863e-213	669.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4D95Q@85008|Micromonosporales	201174|Actinobacteria	C	succinate dehydrogenase	sdhA2	-	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_7448287_5	263358.VAB18032_00360	2.353e-160	512.0	COG0479@1|root,COG0479@2|Bacteria,2GP9C@201174|Actinobacteria,4D9G8@85008|Micromonosporales	201174|Actinobacteria	C	Succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB1	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0247c	Fer2_3,Fer4_8
TLS2_k127_7448287_16	369723.Strop_3770	1.386e-47	181.0	COG1051@1|root,COG1051@2|Bacteria,2IQEA@201174|Actinobacteria,4DE0K@85008|Micromonosporales	201174|Actinobacteria	F	NUDIX domain	mutT2	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS2_k127_7448287_25	649831.L083_7407	2.686e-28	117.0	COG2154@1|root,COG2154@2|Bacteria,2GVRA@201174|Actinobacteria,4DG2D@85008|Micromonosporales	201174|Actinobacteria	H	pterin-4-alpha-carbinolamine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Pterin_4a
TLS2_k127_7448287_22	1108045.GORHZ_141_00570	2.538e-31	124.0	COG2026@1|root,COG2026@2|Bacteria,2GRQR@201174|Actinobacteria,4GEQW@85026|Gordoniaceae	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	relE	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045926,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575	-	-	-	-	-	-	-	-	-	-	ParE_toxin
TLS2_k127_7448287_24	1108045.GORHZ_141_00580	6.053e-29	118.0	COG2161@1|root,COG2161@2|Bacteria,2GUI1@201174|Actinobacteria,4GEEA@85026|Gordoniaceae	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	relF	GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS2_k127_7448287_12	1122138.AQUZ01000052_gene8371	5.918e-87	297.0	COG0500@1|root,COG2226@2|Bacteria,2GKH6@201174|Actinobacteria,4DU05@85009|Propionibacteriales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_7448287_3	35754.JNYJ01000007_gene2798	2.688e-189	597.0	COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria,4DASI@85008|Micromonosporales	201174|Actinobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
TLS2_k127_7448287_2	644283.Micau_5368	8.928e-206	653.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,2GITG@201174|Actinobacteria,4DBEK@85008|Micromonosporales	201174|Actinobacteria	K	AlkA N-terminal domain	alkA	-	3.2.2.21	ko:K13529	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
TLS2_k127_7448287_18	356851.JOAN01000032_gene2815	1.397e-45	185.0	COG0350@1|root,COG0350@2|Bacteria,2IHP1@201174|Actinobacteria,4DD7R@85008|Micromonosporales	201174|Actinobacteria	L	Methyltransferase	ada	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
TLS2_k127_7448287_20	1136417.AZWE01000010_gene2862	1.261e-40	156.0	COG1826@1|root,COG1826@2|Bacteria,2IKS9@201174|Actinobacteria,4DE71@85008|Micromonosporales	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatB	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS2_k127_7448287_7	263358.VAB18032_08100	5.181e-128	422.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4DBHP@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase s1 and s6 chymotrypsin hap	sprI	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_7448287_4	356851.JOAN01000001_gene3642	3.06e-167	539.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4DB1A@85008|Micromonosporales	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS2_k127_7448287_23	219305.MCAG_03462	1.65e-29	118.0	2E39N@1|root,32Y97@2|Bacteria,2GQFF@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3117
TLS2_k127_7448287_8	644283.Micau_0661	4.241e-114	372.0	COG3327@1|root,COG3327@2|Bacteria,2GNME@201174|Actinobacteria,4DAEG@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator, PaaX family	paaX	-	-	ko:K02616	-	-	-	-	ko00000,ko03000	-	-	-	PaaX,PaaX_C
TLS2_k127_7448287_9	1150864.MILUP08_40753	1.681e-102	346.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4D8MH@85008|Micromonosporales	201174|Actinobacteria	I	enoyl-CoA hydratase	chcB	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS2_k127_7448287_28	749414.SBI_08098	2.119e-16	89.0	2DNZV@1|root,32ZZ1@2|Bacteria,2GQPH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7448287_21	1114959.SZMC14600_06021	1.708e-38	150.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_7448287_27	656024.FsymDg_1895	4.769e-19	94.0	2BBGE@1|root,324ZT@2|Bacteria,2HA09@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
TLS2_k127_7448287_26	356851.JOAN01000001_gene3636	1.888e-23	100.0	2FHCZ@1|root,34977@2|Bacteria,2IG11@201174|Actinobacteria,4DCQC@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7448287_13	263358.VAB18032_08065	3.307e-86	290.0	COG2818@1|root,COG2818@2|Bacteria,2IFH0@201174|Actinobacteria,4D8XY@85008|Micromonosporales	201174|Actinobacteria	L	3-methyladenine DNA glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
TLS2_k127_7448287_14	391037.Sare_0651	1.125e-71	247.0	COG3427@1|root,COG3427@2|Bacteria,2IGE1@201174|Actinobacteria,4DCV6@85008|Micromonosporales	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_7448287_19	649831.L083_7632	7.918e-42	166.0	COG3599@1|root,COG3599@2|Bacteria,2I1AQ@201174|Actinobacteria,4DE97@85008|Micromonosporales	201174|Actinobacteria	D	regulation of cell shape	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7448287_15	33876.JNXY01000026_gene3367	1.272e-57	204.0	COG0838@1|root,COG0838@2|Bacteria,2IFDT@201174|Actinobacteria,4DDRH@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoA2	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TLS2_k127_7448287_11	479431.Namu_5134	1.476e-88	303.0	COG3153@1|root,COG3153@2|Bacteria,2I3ZT@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_7448287_10	263358.VAB18032_25785	2.95e-89	297.0	COG2229@1|root,COG2229@2|Bacteria,2GM4V@201174|Actinobacteria,4DB37@85008|Micromonosporales	201174|Actinobacteria	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
TLS2_k127_7448287_29	1068980.ARVW01000001_gene3008	2.386e-11	69.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	2.7.1.83	ko:K16328	ko00240,map00240	-	R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DUF3489,DUF742
TLS2_k127_7448287_17	1122182.KB903814_gene3069	5.944e-47	172.0	COG2018@1|root,COG2018@2|Bacteria,2IFF6@201174|Actinobacteria,4DE3E@85008|Micromonosporales	201174|Actinobacteria	S	Roadblock/LC7 domain	-	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
TLS2_k127_7448287_1	644283.Micau_4288	7.532e-210	679.0	COG0642@1|root,COG3266@1|root,COG0642@2|Bacteria,COG3266@2|Bacteria,2GKY7@201174|Actinobacteria,4D9BD@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,NIT
TLS2_k127_7448287_6	1122182.KB903814_gene3071	8.296e-135	447.0	COG1657@1|root,COG1657@2|Bacteria,2GM7H@201174|Actinobacteria,4DATU@85008|Micromonosporales	201174|Actinobacteria	I	Squalene-hopene cyclase C-terminal domain	-	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009267,GO:0009605,GO:0009607,GO:0009975,GO:0009987,GO:0009991,GO:0010350,GO:0016101,GO:0016102,GO:0016114,GO:0016853,GO:0016872,GO:0019637,GO:0031667,GO:0031668,GO:0031669,GO:0033385,GO:0033554,GO:0035439,GO:0035440,GO:0042594,GO:0043167,GO:0043169,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071496,GO:0071704,GO:0075136,GO:1901576	5.5.1.16	ko:K17811	-	-	-	-	ko00000,ko01000	-	-	-	Prenyltrans,SQHop_cyclase_C
TLS2_k127_778065_38	1410634.JHVD01000001_gene1480	3.405e-12	71.0	2E9KH@1|root,333T8@2|Bacteria,2GT95@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_778065_39	1122239.AULS01000002_gene1012	4.256e-09	66.0	2E9KH@1|root,333T8@2|Bacteria,2H05X@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_778065_33	981369.JQMJ01000002_gene6	9.168e-51	182.0	COG3385@1|root,COG3385@2|Bacteria,2GJUG@201174|Actinobacteria,2NIZY@228398|Streptacidiphilus	201174|Actinobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
TLS2_k127_778065_27	1122622.ATWJ01000015_gene493	2.809e-69	248.0	COG3409@1|root,COG3409@2|Bacteria,2IIDJ@201174|Actinobacteria,4FHXW@85021|Intrasporangiaceae	201174|Actinobacteria	M	PFAM Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
TLS2_k127_778065_24	1410634.JHVD01000029_gene2074	3.973e-81	282.0	COG1136@1|root,COG1136@2|Bacteria,2IGYA@201174|Actinobacteria	201174|Actinobacteria	V	Pfam ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_778065_23	1122622.ATWJ01000015_gene495	3.592e-82	291.0	COG0577@1|root,COG0577@2|Bacteria,2IG8W@201174|Actinobacteria,4FHRC@85021|Intrasporangiaceae	201174|Actinobacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_778065_21	656024.FsymDg_4168	6.307e-89	312.0	COG3177@1|root,COG3177@2|Bacteria,2ITFK@201174|Actinobacteria	201174|Actinobacteria	S	Filamentation induced by cAMP protein fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic
TLS2_k127_778065_12	391037.Sare_0286	6.01e-160	511.0	COG1820@1|root,COG1820@2|Bacteria,2GK1E@201174|Actinobacteria,4D9GP@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS2_k127_778065_14	1150864.MILUP08_40339	4.733e-140	451.0	COG1427@1|root,COG1427@2|Bacteria,2GJGY@201174|Actinobacteria,4D8EF@85008|Micromonosporales	201174|Actinobacteria	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
TLS2_k127_778065_28	391037.Sare_4474	4.838e-67	240.0	COG2367@1|root,COG2367@2|Bacteria,2HU8K@201174|Actinobacteria,4DCTT@85008|Micromonosporales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase2
TLS2_k127_778065_26	1136417.AZWE01000062_gene1454	2.385e-69	247.0	COG2367@1|root,COG2367@2|Bacteria,2HU4B@201174|Actinobacteria,4DAXM@85008|Micromonosporales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_778065_10	644283.Micau_0381	4.092e-192	603.0	COG3396@1|root,COG3396@2|Bacteria,2GMQ3@201174|Actinobacteria,4D8NM@85008|Micromonosporales	201174|Actinobacteria	S	phenylacetate-CoA oxygenase	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
TLS2_k127_778065_35	369723.Strop_4072	3.885e-44	165.0	COG3460@1|root,COG3460@2|Bacteria,2IKMJ@201174|Actinobacteria,4DE7H@85008|Micromonosporales	201174|Actinobacteria	Q	phenylacetate-CoA oxygenase	paaB	-	-	ko:K02610	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	PaaB
TLS2_k127_778065_20	219305.MCAG_03167	6.985e-95	330.0	COG3396@1|root,COG3396@2|Bacteria,2GJIU@201174|Actinobacteria,4D8DP@85008|Micromonosporales	201174|Actinobacteria	S	phenylacetic acid	paaI	-	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
TLS2_k127_778065_30	100226.SCO7474	3.368e-56	203.0	COG2151@1|root,COG2151@2|Bacteria,2II4H@201174|Actinobacteria	201174|Actinobacteria	L	phenylacetate-CoA oxygenase, PaaJ subunit	paaJ	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
TLS2_k127_778065_11	263358.VAB18032_06075	1.778e-168	535.0	COG1018@1|root,COG1018@2|Bacteria,2GKGS@201174|Actinobacteria,4D9J2@85008|Micromonosporales	201174|Actinobacteria	C	Phenylacetate-CoA oxygenase reductase, PaaK subunit	paaK	-	-	ko:K02613	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FAD_binding_6,FA_desaturase,Fer2,NAD_binding_1
TLS2_k127_778065_36	543632.JOJL01000068_gene3298	9.523e-37	147.0	COG3409@1|root,COG3409@2|Bacteria,2HUZI@201174|Actinobacteria,4DGE9@85008|Micromonosporales	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_778065_25	68219.JNXI01000003_gene4452	3.359e-77	271.0	COG0739@1|root,COG0739@2|Bacteria,2I9IY@201174|Actinobacteria	201174|Actinobacteria	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_778065_13	369723.Strop_3890	4.108e-140	451.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4D9RZ@85008|Micromonosporales	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_778065_32	479435.Kfla_0036	3.595e-51	193.0	COG0350@1|root,COG0350@2|Bacteria,2IHXW@201174|Actinobacteria,4DQMF@85009|Propionibacteriales	201174|Actinobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
TLS2_k127_778065_7	649831.L083_0413	1.946e-218	685.0	COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4D8KI@85008|Micromonosporales	201174|Actinobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
TLS2_k127_778065_37	1120949.KB903303_gene6801	3.491e-32	132.0	2DXBW@1|root,344BC@2|Bacteria,2ISJM@201174|Actinobacteria,4DK3K@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_778065_1	1120949.KB903311_gene746	0.0	1092.0	COG0265@1|root,COG1474@1|root,COG2319@1|root,COG0265@2|Bacteria,COG1474@2|Bacteria,COG2319@2|Bacteria,2GJV1@201174|Actinobacteria	201174|Actinobacteria	LO	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2,WD40
TLS2_k127_778065_18	1150864.MILUP08_40353	2.16e-103	342.0	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4DAGF@85008|Micromonosporales	201174|Actinobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS2_k127_778065_8	1464048.JNZS01000013_gene3182	4.536e-207	650.0	COG0644@1|root,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria,4DAZF@85008|Micromonosporales	201174|Actinobacteria	C	geranylgeranyl reductase	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
TLS2_k127_778065_31	644283.Micau_0395	1.355e-52	188.0	COG0838@1|root,COG0838@2|Bacteria,2IKWT@201174|Actinobacteria,4DDD2@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TLS2_k127_778065_17	1122182.KB903813_gene2325	9.605e-109	356.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,4D8NQ@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TLS2_k127_778065_15	391037.Sare_4461	7.734e-122	395.0	COG0852@1|root,COG0852@2|Bacteria,2GIRH@201174|Actinobacteria,4D9YC@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TLS2_k127_778065_4	1121272.KB903293_gene7401	1.046e-246	771.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4DAVY@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS2_k127_778065_16	35754.JNYJ01000036_gene3787	1.451e-115	377.0	COG1905@1|root,COG1905@2|Bacteria,2GKG0@201174|Actinobacteria,4DA51@85008|Micromonosporales	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase 24 kD subunit	nuoE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
TLS2_k127_778065_3	35754.JNYJ01000036_gene3786	7.738e-251	778.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4DAYA@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
TLS2_k127_778065_0	1150864.MILUP08_40362	0.0	1124.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,4D8GG@85008|Micromonosporales	201174|Actinobacteria	C	NADH-quinone oxidoreductase	nuoG	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
TLS2_k127_778065_9	1136417.AZWE01000048_gene2741	7.577e-195	617.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4D8E0@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS2_k127_778065_19	1121272.KB903293_gene7396	7.059e-98	328.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4DATK@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.5.3	ko:K00338,ko:K12143	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3153	Fer4
TLS2_k127_778065_22	543632.JOJL01000041_gene1930	5.654e-88	300.0	COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria,4D9YY@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS2_k127_778065_34	561175.KB894093_gene4358	3.137e-44	162.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria,4EJPX@85012|Streptosporangiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS2_k127_778065_2	1122182.KB903813_gene2335	1.818e-295	918.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4D8WN@85008|Micromonosporales	201174|Actinobacteria	CP	NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TLS2_k127_778065_6	1246995.AFR_01715	4.131e-231	736.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4D9KD@85008|Micromonosporales	201174|Actinobacteria	C	proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_778065_5	710687.KI912270_gene2395	1.79e-239	749.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,2358Z@1762|Mycobacteriaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_778065_29	710687.KI912270_gene2396	1.937e-59	206.0	COG1309@1|root,COG1309@2|Bacteria,2I9NV@201174|Actinobacteria,237T3@1762|Mycobacteriaceae	201174|Actinobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
TLS2_k127_839877_21	1303518.CCALI_01631	1.335e-38	164.0	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	-	ko:K12204	-	-	-	-	ko00000,ko02044	3.A.7.10.1,3.A.7.9.1	-	-	DUF2235,FecR,LysM
TLS2_k127_839877_24	1151119.KB895518_gene2627	4.374e-17	95.0	COG0726@1|root,COG5479@1|root,COG0726@2|Bacteria,COG5479@2|Bacteria,2GN2D@201174|Actinobacteria	201174|Actinobacteria	M	protein potentially involved in peptidoglycan biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	LGFP
TLS2_k127_839877_8	656024.FsymDg_3370	6.436e-133	444.0	COG4585@1|root,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria,4ESVV@85013|Frankiales	201174|Actinobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_839877_15	656024.FsymDg_3369	2.887e-77	267.0	COG2197@1|root,COG2197@2|Bacteria,2IDFQ@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_839877_9	263358.VAB18032_10615	1.922e-121	403.0	COG1376@1|root,COG1376@2|Bacteria,2GJBA@201174|Actinobacteria,4DBET@85008|Micromonosporales	201174|Actinobacteria	S	ErfK YbiS YcfS YnhG family protein	lppS	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS2_k127_839877_1	102129.Lepto7375DRAFT_1472	0.0	1103.0	COG0419@1|root,COG0419@2|Bacteria,1GHIS@1117|Cyanobacteria,1HF5W@1150|Oscillatoriales	1117|Cyanobacteria	L	ATPase involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_839877_5	102129.Lepto7375DRAFT_1471	1.298e-206	676.0	COG3540@1|root,COG3540@2|Bacteria,1G27Q@1117|Cyanobacteria,1H9KJ@1150|Oscillatoriales	1117|Cyanobacteria	P	PFAM PhoD-like phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_839877_4	102129.Lepto7375DRAFT_1470	2.07e-213	681.0	28H5N@1|root,2Z7I8@2|Bacteria,1GCEG@1117|Cyanobacteria,1HE1R@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_839877_0	102129.Lepto7375DRAFT_1469	0.0	1495.0	COG0845@1|root,COG0845@2|Bacteria,1GCFD@1117|Cyanobacteria,1HF90@1150|Oscillatoriales	1117|Cyanobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_839877_2	102129.Lepto7375DRAFT_1468	1.376e-320	1011.0	COG0222@1|root,COG0222@2|Bacteria	2|Bacteria	J	mitochondrial gene expression	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_839877_22	1869.MB27_06325	5.417e-35	138.0	COG1725@1|root,COG1725@2|Bacteria,2IHTD@201174|Actinobacteria,4DEPZ@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
TLS2_k127_839877_23	749414.SBI_03194	2.644e-30	132.0	2F2DM@1|root,33VBA@2|Bacteria,2HHW0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648
TLS2_k127_839877_20	1136417.AZWE01000015_gene1506	2.877e-40	151.0	COG2840@1|root,COG2840@2|Bacteria,2IQ5F@201174|Actinobacteria,4DEUB@85008|Micromonosporales	201174|Actinobacteria	S	Smr domain	-	-	-	-	-	-	-	-	-	-	-	-	Smr
TLS2_k127_839877_12	1449976.KALB_2287	3.592e-105	349.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DYUU@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_839877_14	1449976.KALB_2288	8.39e-96	322.0	COG0842@1|root,COG0842@2|Bacteria,2GJGH@201174|Actinobacteria,4E037@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_839877_3	103733.JNYO01000009_gene4731	1.545e-225	708.0	COG2939@1|root,COG2939@2|Bacteria,2GK9N@201174|Actinobacteria,4DYWR@85010|Pseudonocardiales	201174|Actinobacteria	E	Serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
TLS2_k127_839877_19	644283.Micau_1727	4.127e-49	186.0	2FAQW@1|root,33HHA@2|Bacteria,2I5IX@201174|Actinobacteria,4DMQG@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_839877_18	390989.JOEG01000027_gene2139	9.43e-65	233.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4DBSK@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family	-	-	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	STAS_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_839877_16	543632.JOJL01000002_gene8338	5.333e-76	262.0	COG2203@1|root,COG2203@2|Bacteria,2IQAM@201174|Actinobacteria,4DCWS@85008|Micromonosporales	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS2_k127_839877_13	543632.JOJL01000002_gene8357	1.422e-101	336.0	COG2203@1|root,COG2203@2|Bacteria,2GQ2V@201174|Actinobacteria,4DCK4@85008|Micromonosporales	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS2_k127_839877_7	1232429.CBLL010000123_gene1258	1.763e-146	472.0	COG0395@1|root,COG0395@2|Bacteria,2GKEE@201174|Actinobacteria,1W99D@1268|Micrococcaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_839877_10	1232429.CBLL010000123_gene1259	7.569e-121	398.0	COG1175@1|root,COG1175@2|Bacteria,2GM6N@201174|Actinobacteria,1W887@1268|Micrococcaceae	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	sugC	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_839877_6	1232429.CBLL010000124_gene1372	6.694e-167	534.0	COG1653@1|root,COG1653@2|Bacteria,2GM4E@201174|Actinobacteria,1W8PA@1268|Micrococcaceae	201174|Actinobacteria	G	extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_839877_17	1449976.KALB_1014	7.414e-68	248.0	COG0745@1|root,COG1587@1|root,COG0745@2|Bacteria,COG1587@2|Bacteria,2GKMM@201174|Actinobacteria,4DXMG@85010|Pseudonocardiales	201174|Actinobacteria	HK	Uroporphyrinogen-III synthase HemD	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,Trans_reg_C
TLS2_k127_839877_11	1122182.KB903837_gene3871	3.154e-111	372.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria,4DB28@85008|Micromonosporales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027,ko:K10232	ko02010,map02010	M00201,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_863492_3	401526.TcarDRAFT_0062	6.053e-07	55.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes	1239|Firmicutes	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_863492_0	1894.JOER01000046_gene4605	5.29e-168	536.0	COG1403@1|root,COG3344@1|root,COG1403@2|Bacteria,COG3344@2|Bacteria,2GUJS@201174|Actinobacteria	201174|Actinobacteria	L	RNA-directed DNA polymerase (reverse transcriptase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,HNH,RVT_1,RVT_N
TLS2_k127_967909_3	356851.JOAN01000014_gene2142	1.389e-133	431.0	COG1960@1|root,COG1960@2|Bacteria,2GJHM@201174|Actinobacteria,4D9D4@85008|Micromonosporales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	aidB	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
TLS2_k127_967909_7	1196028.ALEF01000078_gene2971	0.0002493	52.0	2D6A1@1|root,32TKT@2|Bacteria,1VBSN@1239|Firmicutes,4HM9X@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_967909_5	1121946.AUAX01000004_gene938	1.899e-61	214.0	2CNY9@1|root,31DSU@2|Bacteria,2I80U@201174|Actinobacteria,4DDR9@85008|Micromonosporales	201174|Actinobacteria	K	Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters	rbpA	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	RbpA
TLS2_k127_967909_6	391037.Sare_2390	2.173e-41	168.0	COG3030@1|root,COG3030@2|Bacteria,2IA8V@201174|Actinobacteria,4DD8P@85008|Micromonosporales	201174|Actinobacteria	S	FxsA cytoplasmic membrane protein	-	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
TLS2_k127_967909_4	35754.JNYJ01000046_gene3117	9.317e-114	381.0	COG1216@1|root,COG1216@2|Bacteria,2I2FA@201174|Actinobacteria,4DBFZ@85008|Micromonosporales	201174|Actinobacteria	S	Glycosyltransferase like family 2	ppm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
TLS2_k127_967909_1	644283.Micau_3130	1.426e-183	594.0	COG0815@1|root,COG0815@2|Bacteria,2GJ9F@201174|Actinobacteria,4D8UB@85008|Micromonosporales	201174|Actinobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	GO:0000030,GO:0003674,GO:0003824,GO:0004582,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052564,GO:0052572,GO:0070085,GO:0071704,GO:0071944,GO:0075136,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	iNJ661.Rv2051c	CN_hydrolase
TLS2_k127_967909_2	457429.ABJI02000827_gene2453	3.368e-150	496.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TLS2_k127_967909_0	1123368.AUIS01000003_gene1805	1.096e-239	755.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,1RS4U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Glucoamylase and related glycosyl hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
## 4006 queries scanned
## Total time (seconds): 191.37839007377625
## Rate: 20.93 q/s