## Thu Oct 17 14:55:12 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/TLS2_bin.13.fa -m mmseqs --itype genome -o TLS2_bin.13 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/TLS2_bin.13 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TLS2_k127_100375_0	1267535.KB906767_gene1751	8.871e-243	759.0	COG1185@1|root,COG1185@2|Bacteria,3Y2UG@57723|Acidobacteria,2JI5F@204432|Acidobacteriia	204432|Acidobacteriia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TLS2_k127_100375_1	1267535.KB906767_gene1750	1.235e-30	123.0	COG0184@1|root,COG0184@2|Bacteria,3Y5R5@57723|Acidobacteria	57723|Acidobacteria	J	Ribosomal_S15	-	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
TLS2_k127_1021148_3	1047013.AQSP01000125_gene2637	2.924e-69	256.0	COG0823@1|root,COG4946@1|root,COG0823@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Amidohydro_1,PD40,PG_binding_1,Pkinase,TolB_N
TLS2_k127_1021148_2	234267.Acid_1946	3.99e-80	282.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_1946|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1021148_5	118173.KB235914_gene3889	1.344e-20	101.0	COG0457@1|root,COG0457@2|Bacteria,1G1QI@1117|Cyanobacteria,1H6XA@1150|Oscillatoriales	1117|Cyanobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,TPR_12,TPR_7
TLS2_k127_1021148_0	395495.Lcho_1398	1.435e-143	464.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,1KN02@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_1021148_4	234267.Acid_7037	1.003e-43	167.0	COG0468@1|root,COG0468@2|Bacteria,3Y4QB@57723|Acidobacteria	57723|Acidobacteria	L	recA bacterial DNA recombination protein	-	-	-	-	-	-	-	-	-	-	-	-	RecA
TLS2_k127_1021148_1	234267.Acid_7036	2.619e-105	358.0	COG0389@1|root,COG0389@2|Bacteria,3Y3EV@57723|Acidobacteria	57723|Acidobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
TLS2_k127_1023744_15	766499.C357_09563	7.49e-14	80.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cadherin_3,Calx-beta,DUF11,SdrD_B,VPEP
TLS2_k127_1023744_8	234267.Acid_0924	1.054e-42	159.0	COG3162@1|root,COG3162@2|Bacteria	2|Bacteria	S	Protein of unknown function, DUF485	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
TLS2_k127_1023744_0	234267.Acid_0925	1.431e-266	828.0	COG4147@1|root,COG4147@2|Bacteria	2|Bacteria	S	glycolate transport	ywcA	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	iAF987.Gmet_0739	SSF
TLS2_k127_1023744_4	234267.Acid_1787	3.278e-82	282.0	COG1075@1|root,COG1075@2|Bacteria,3Y77G@57723|Acidobacteria	57723|Acidobacteria	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1023744_1	234267.Acid_1790	6.498e-151	494.0	COG0661@1|root,COG0661@2|Bacteria,3Y6NE@57723|Acidobacteria	57723|Acidobacteria	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
TLS2_k127_1023744_6	1267535.KB906767_gene4477	8.189e-69	247.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS2_k127_1023744_2	234267.Acid_1785	5.562e-116	394.0	COG1020@1|root,COG1020@2|Bacteria,3Y61Y@57723|Acidobacteria	57723|Acidobacteria	H	Protein of unknown function (DUF1298)	-	-	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
TLS2_k127_1023744_11	1038862.KB893895_gene7154	2.538e-32	132.0	COG1247@1|root,COG1247@2|Bacteria,1R6UW@1224|Proteobacteria,2U09H@28211|Alphaproteobacteria,3JQVX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Acetyltransferase (GNAT) domain	MA20_16670	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_1023744_9	234267.Acid_1788	1.412e-36	154.0	2F22H@1|root,33V1C@2|Bacteria,3Y7HC@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1023744_10	204669.Acid345_0351	8.72e-33	132.0	COG5394@1|root,COG5394@2|Bacteria,3Y7TC@57723|Acidobacteria	57723|Acidobacteria	K	PHB/PHA accumulation regulator DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PHB_acc_N
TLS2_k127_1023744_7	1123508.JH636439_gene1336	5.885e-46	168.0	COG1733@1|root,COG1733@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS2_k127_1023744_3	1052684.PPM_0679	1.507e-94	317.0	COG1028@1|root,COG1028@2|Bacteria,1U2GS@1239|Firmicutes,4H9R9@91061|Bacilli,26QGX@186822|Paenibacillaceae	91061|Bacilli	IQ	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	ucpA	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_1023744_12	316055.RPE_2603	9.772e-22	97.0	COG2203@1|root,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria,2TXJP@28211|Alphaproteobacteria,3JWG0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF,HTH_17
TLS2_k127_1023744_14	1101191.KI912577_gene1249	1.999e-15	76.0	COG2203@1|root,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria,2V7EM@28211|Alphaproteobacteria,1JXVM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HTH_3
TLS2_k127_1023744_13	1349767.GJA_2514	1.277e-15	81.0	COG0596@1|root,COG0596@2|Bacteria,1RB9C@1224|Proteobacteria	1224|Proteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_1023744_16	439375.Oant_0831	2.655e-09	60.0	COG0596@1|root,COG0596@2|Bacteria,1RB9C@1224|Proteobacteria,2U4ZB@28211|Alphaproteobacteria,1J3I6@118882|Brucellaceae	28211|Alphaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_1023744_5	240015.ACP_1727	2.963e-73	253.0	COG1028@1|root,COG1028@2|Bacteria	240015.ACP_1727|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1024658_2	1038862.KB893837_gene1612	1.125e-18	86.0	COG0323@1|root,COG0323@2|Bacteria,1P2C7@1224|Proteobacteria,2U35K@28211|Alphaproteobacteria,3K40H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_3
TLS2_k127_1024658_0	670292.JH26_00425	8.364e-135	432.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,1JTSW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
TLS2_k127_1024658_3	349102.Rsph17025_1827	5.577e-17	83.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
TLS2_k127_1024658_1	622637.KE124774_gene2611	4.274e-45	164.0	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,36YR7@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
TLS2_k127_1041212_5	909663.KI867150_gene405	3.598e-29	121.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,42QPY@68525|delta/epsilon subdivisions,2WMQC@28221|Deltaproteobacteria,2MQD4@213462|Syntrophobacterales	28221|Deltaproteobacteria	EQ	PFAM Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
TLS2_k127_1041212_0	1340493.JNIF01000003_gene3822	7.521e-220	707.0	COG0744@1|root,COG0744@2|Bacteria	2|Bacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
TLS2_k127_1041212_2	234267.Acid_4095	2.244e-63	226.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_1041212_6	1250232.JQNJ01000001_gene1969	7.465e-22	106.0	COG3595@1|root,COG3595@2|Bacteria,4NJBA@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1041212_4	1340493.JNIF01000003_gene1336	1.59e-42	166.0	COG5660@1|root,COG5660@2|Bacteria	2|Bacteria	S	Putative zinc-finger	sigC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	zf-HC2
TLS2_k127_1041212_3	234267.Acid_4092	9.792e-43	164.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_1061060_6	234267.Acid_6694	5.348e-47	177.0	2E98K@1|root,333GZ@2|Bacteria,3Y55V@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1061060_7	1316936.K678_12177	3.15e-11	68.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TSQF@28211|Alphaproteobacteria,2JRP8@204441|Rhodospirillales	204441|Rhodospirillales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	ompR	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_1061060_2	234267.Acid_6696	6.001e-102	338.0	COG0745@1|root,COG0745@2|Bacteria,3Y4GX@57723|Acidobacteria	57723|Acidobacteria	T	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_1061060_5	1121033.AUCF01000037_gene3912	9.415e-53	190.0	COG1764@1|root,COG1764@2|Bacteria,1RHVR@1224|Proteobacteria,2VG83@28211|Alphaproteobacteria,2JTM8@204441|Rhodospirillales	204441|Rhodospirillales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_1061060_1	234267.Acid_2703	5.317e-138	456.0	28N30@1|root,2ZB8S@2|Bacteria,3Y2XH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1061060_4	234267.Acid_2011	8.71e-80	273.0	COG0325@1|root,COG0325@2|Bacteria,3Y4CY@57723|Acidobacteria	57723|Acidobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
TLS2_k127_1061060_3	234267.Acid_2012	5.601e-97	328.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	sumf2	-	-	ko:K15257	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DinB_2,FGE-sulfatase,Methyltransf_11,Methyltransf_14,Methyltransf_23,Methyltransf_25,Methyltransf_31
TLS2_k127_1061060_0	234267.Acid_2013	7.157e-195	628.0	COG2936@1|root,COG2936@2|Bacteria,3Y6W3@57723|Acidobacteria	57723|Acidobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
TLS2_k127_106258_4	1382359.JIAL01000001_gene923	2.725e-12	76.0	COG3170@1|root,COG4409@1|root,COG5306@1|root,COG3170@2|Bacteria,COG4409@2|Bacteria,COG5306@2|Bacteria,3Y2GG@57723|Acidobacteria,2JI5J@204432|Acidobacteriia	2|Bacteria	G	Belongs to the peptidase S8 family	exbB2	-	-	ko:K03561,ko:K12287,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000,ko02044	1.A.30.2.1	-	-	Big_3_2,DUF2341,Laminin_G_3,MotA_ExbB
TLS2_k127_106258_2	234267.Acid_4920	1.594e-42	166.0	COG2264@1|root,COG2264@2|Bacteria	2|Bacteria	J	protein methyltransferase activity	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_21,Methyltransf_23,Methyltransf_31,PrmA,rRNA_methylase
TLS2_k127_106258_3	215803.DB30_8105	2.121e-16	87.0	COG2227@1|root,COG2227@2|Bacteria,1QX9R@1224|Proteobacteria,43C2X@68525|delta/epsilon subdivisions,2X7DJ@28221|Deltaproteobacteria,2Z3FT@29|Myxococcales	28221|Deltaproteobacteria	H	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_106258_1	234267.Acid_0271	1.498e-139	456.0	COG0438@1|root,COG0438@2|Bacteria,3Y64B@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
TLS2_k127_106258_0	234267.Acid_0272	4.555e-287	896.0	COG0367@1|root,COG0367@2|Bacteria,3Y75N@57723|Acidobacteria	57723|Acidobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
TLS2_k127_106258_5	1301098.PKB_2748	1.147e-09	71.0	COG3307@1|root,COG3307@2|Bacteria,1RBK5@1224|Proteobacteria,1S2Y8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Polymerase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TLS2_k127_1064903_0	1209072.ALBT01000058_gene840	1.247e-226	713.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMSH@1236|Gammaproteobacteria,1FFU9@10|Cellvibrio	1236|Gammaproteobacteria	G	Maltogenic Amylase, C-terminal domain	aglA	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459,Malt_amylase_C
TLS2_k127_1074851_4	1267535.KB906767_gene2570	1.113e-14	78.0	COG2001@1|root,COG2001@2|Bacteria,3Y4NF@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
TLS2_k127_1074851_1	1267535.KB906767_gene2569	8.375e-113	371.0	COG0275@1|root,COG0275@2|Bacteria,3Y31S@57723|Acidobacteria,2JHM1@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
TLS2_k127_1074851_3	234267.Acid_7318	2.199e-19	95.0	COG2919@1|root,COG2919@2|Bacteria,3Y4JZ@57723|Acidobacteria	57723|Acidobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	-	-	-	-	-	-	-	-	-	-	-	-	DivIC,FtsL
TLS2_k127_1074851_0	1267535.KB906767_gene2567	3.681e-169	554.0	COG0768@1|root,COG0768@2|Bacteria,3Y2XX@57723|Acidobacteria,2JHPS@204432|Acidobacteriia	204432|Acidobacteriia	M	Penicillin-binding protein, dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
TLS2_k127_1074851_2	234267.Acid_7316	8.69e-102	338.0	COG0769@1|root,COG0769@2|Bacteria,3Y38W@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_1083892_1	1220534.B655_0122	2.897e-35	152.0	COG1807@1|root,arCOG00566@2157|Archaea,2Y4H0@28890|Euryarchaeota	28890|Euryarchaeota	M	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_1083892_0	716928.AJQT01000077_gene931	1.876e-54	195.0	COG1595@1|root,COG1595@2|Bacteria,1MXVA@1224|Proteobacteria,2TV85@28211|Alphaproteobacteria,4BAXG@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigJ	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_1083892_2	1231185.BAMP01000116_gene1504	4.866e-14	77.0	COG1595@1|root,COG1595@2|Bacteria,1MXVA@1224|Proteobacteria,2TV85@28211|Alphaproteobacteria,43HK9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family	sigJ	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_1085529_4	41431.PCC8801_4097	5.884e-38	157.0	COG0627@1|root,COG0627@2|Bacteria,1GGBS@1117|Cyanobacteria	1117|Cyanobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
TLS2_k127_1085529_6	1122927.KB895428_gene300	3.979e-26	120.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1TSRS@1239|Firmicutes,4ISIU@91061|Bacilli,26QP4@186822|Paenibacillaceae	91061|Bacilli	K	AraC family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
TLS2_k127_1085529_1	926550.CLDAP_32450	8.97e-108	366.0	COG1070@1|root,COG1070@2|Bacteria,2G5QX@200795|Chloroflexi	2|Bacteria	G	PFAM carbohydrate kinase	-	-	2.7.1.12,2.7.1.17,2.7.1.215,2.7.1.5	ko:K00848,ko:K00851,ko:K00854,ko:K00862	ko00030,ko00040,ko00051,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00040,map00051,map01100,map01110,map01120,map01130,map01200	M00014	R01639,R01737,R01902,R03014,R11536	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS2_k127_1085529_5	1416752.AYME01000002_gene795	7.706e-37	148.0	COG0794@1|root,COG0794@2|Bacteria,2IE8A@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Sugar isomerase (SIS)	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS
TLS2_k127_1085529_3	926550.CLDAP_32440	1.055e-80	281.0	COG1063@1|root,COG1063@2|Bacteria,2G6PM@200795|Chloroflexi	200795|Chloroflexi	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_1085529_0	472175.EL18_03370	4.476e-129	428.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2TRZ0@28211|Alphaproteobacteria,43N99@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	SAF	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_3,SAF
TLS2_k127_1085529_2	926569.ANT_13690	8.894e-102	338.0	COG2407@1|root,COG2407@2|Bacteria,2G84V@200795|Chloroflexi	200795|Chloroflexi	G	L-fucose isomerase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Fucose_iso_C
TLS2_k127_1086813_3	1340493.JNIF01000003_gene1970	2.184e-30	121.0	COG0684@1|root,COG0684@2|Bacteria,3Y3TT@57723|Acidobacteria	57723|Acidobacteria	H	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
TLS2_k127_1086813_1	639030.JHVA01000001_gene258	5.617e-89	300.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	PmoA,ThuA
TLS2_k127_1086813_0	497964.CfE428DRAFT_1841	6.588e-120	391.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_1086813_2	234267.Acid_5579	1.653e-40	153.0	COG5592@1|root,COG5592@2|Bacteria	2|Bacteria	I	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin,Phasin_2
TLS2_k127_1092215_1	234267.Acid_6502	2.345e-63	221.0	COG0149@1|root,COG0149@2|Bacteria,3Y2YS@57723|Acidobacteria	57723|Acidobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TLS2_k127_1092215_0	1267535.KB906767_gene4085	2.16e-120	391.0	COG1015@1|root,COG1015@2|Bacteria,3Y6GB@57723|Acidobacteria	57723|Acidobacteria	G	Metalloenzyme superfamily	-	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
TLS2_k127_109863_1	1340493.JNIF01000004_gene597	7.012e-98	333.0	COG1629@1|root,COG1629@2|Bacteria,3Y6Z5@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_109863_0	234267.Acid_2813	1.611e-206	668.0	COG0577@1|root,COG0577@2|Bacteria,3Y6QF@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_109863_2	1267535.KB906767_gene1546	8.231e-62	226.0	COG3132@1|root,COG3132@2|Bacteria,3Y50M@57723|Acidobacteria,2JMSB@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the UPF0502 family	-	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
TLS2_k127_1103002_2	1089551.KE386572_gene3307	6.081e-10	67.0	COG1508@1|root,COG1508@2|Bacteria,1REMJ@1224|Proteobacteria,2UADX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1103002_3	1089551.KE386572_gene3307	0.0004424	45.0	COG1508@1|root,COG1508@2|Bacteria,1REMJ@1224|Proteobacteria,2UADX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1103002_0	1121106.JQKB01000029_gene4877	2.905e-20	93.0	28MCN@1|root,2ZAQR@2|Bacteria,1N00X@1224|Proteobacteria,2UG9Y@28211|Alphaproteobacteria,2JUVD@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1103372_2	760192.Halhy_5052	1.282e-28	115.0	COG0428@1|root,COG0428@2|Bacteria,4NGQ8@976|Bacteroidetes,1INMZ@117747|Sphingobacteriia	976|Bacteroidetes	P	ZIP Zinc transporter	gufA	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
TLS2_k127_1103372_0	639030.JHVA01000001_gene1797	3.217e-52	201.0	COG1629@1|root,COG1629@2|Bacteria,3Y39E@57723|Acidobacteria,2JIU9@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_1115893_0	521674.Plim_0517	8.17e-189	612.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PSCyt1,PSCyt2,PSD1
TLS2_k127_1117202_3	234267.Acid_0400	4.265e-67	233.0	COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	-
TLS2_k127_1117202_0	234267.Acid_0399	6.254e-173	556.0	COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria	2|Bacteria	C	Polysulphide reductase, NrfD	qrcD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
TLS2_k127_1117202_2	234267.Acid_0398	3.488e-70	245.0	COG0509@1|root,COG0509@2|Bacteria	2|Bacteria	E	glycine decarboxylation via glycine cleavage system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H,Response_reg
TLS2_k127_1117202_1	234267.Acid_0394	6.907e-113	368.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02481,ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_1124991_1	1267535.KB906767_gene422	1.36e-38	146.0	COG1695@1|root,COG1695@2|Bacteria,3Y873@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_1124991_0	1267535.KB906767_gene5107	1.752e-109	374.0	COG0577@1|root,COG0577@2|Bacteria,3Y76A@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_1135209_6	383372.Rcas_4144	8.426e-22	104.0	COG0277@1|root,COG0277@2|Bacteria,2G6FW@200795|Chloroflexi,376EU@32061|Chloroflexia	32061|Chloroflexia	C	PFAM FAD linked oxidase domain protein	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_1135209_0	1267535.KB906767_gene470	2.416e-178	568.0	COG0247@1|root,COG0247@2|Bacteria,3Y6NT@57723|Acidobacteria	57723|Acidobacteria	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
TLS2_k127_1135209_1	1267535.KB906767_gene4064	8.477e-84	282.0	COG1595@1|root,COG1595@2|Bacteria,3Y4CH@57723|Acidobacteria,2JJ6R@204432|Acidobacteriia	204432|Acidobacteriia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_1135209_4	1340493.JNIF01000003_gene3265	1.413e-54	206.0	COG1413@1|root,COG5662@1|root,COG1413@2|Bacteria,COG5662@2|Bacteria,3Y2TB@57723|Acidobacteria	57723|Acidobacteria	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,zf-HC2
TLS2_k127_1135209_5	234267.Acid_5722	9.458e-50	192.0	COG3595@1|root,COG3595@2|Bacteria,3Y8P5@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1135209_3	1340493.JNIF01000003_gene3264	1.078e-61	222.0	COG0265@1|root,COG0265@2|Bacteria,3Y4AJ@57723|Acidobacteria	57723|Acidobacteria	O	PDZ DHR GLGF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2
TLS2_k127_1135209_2	1340493.JNIF01000003_gene3261	6.593e-71	248.0	COG1191@1|root,COG1191@2|Bacteria,3Y4Q5@57723|Acidobacteria	57723|Acidobacteria	K	TIGRFAM RNA polymerase sigma factor, FliA WhiG family	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_1135209_7	927677.ALVU02000001_gene3030	1.117e-06	52.0	COG2837@1|root,COG2837@2|Bacteria,1G3KT@1117|Cyanobacteria	1117|Cyanobacteria	P	peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	Dyp_perox,LysM
TLS2_k127_1137863_3	479432.Sros_2250	4.131e-81	284.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,4EMR2@85012|Streptosporangiales	201174|Actinobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_1137863_0	682795.AciX8_2919	8.432e-260	822.0	COG1643@1|root,COG1643@2|Bacteria,3Y38N@57723|Acidobacteria,2JHKA@204432|Acidobacteriia	204432|Acidobacteriia	L	ATP-dependent helicase HrpB	-	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
TLS2_k127_1137863_1	525897.Dbac_1184	7.695e-181	587.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,1MVRR@1224|Proteobacteria,42NSC@68525|delta/epsilon subdivisions,2WMAX@28221|Deltaproteobacteria,2MBD3@213115|Desulfovibrionales	28221|Deltaproteobacteria	CE	PFAM FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
TLS2_k127_1137863_5	1267535.KB906767_gene4265	9.957e-31	124.0	2FHRB@1|root,349IU@2|Bacteria,3Y8GP@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1137863_4	1537715.JQFJ01000002_gene456	3.297e-65	247.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_1137863_2	1267535.KB906767_gene659	5.161e-106	355.0	COG1273@1|root,COG1273@2|Bacteria,3Y4E7@57723|Acidobacteria,2JNYV@204432|Acidobacteriia	204432|Acidobacteriia	L	Ku70/Ku80 beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Ku
TLS2_k127_1138812_0	269799.Gmet_0776	3.929e-114	375.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,43TKB@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_1138812_2	861299.J421_0551	3.988e-30	121.0	2DNQD@1|root,32YJR@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3303)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3303
TLS2_k127_1138812_4	391625.PPSIR1_16130	1.529e-12	73.0	COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,42Y58@68525|delta/epsilon subdivisions,2WTVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
TLS2_k127_1138812_1	391625.PPSIR1_16130	4.204e-59	213.0	COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,42Y58@68525|delta/epsilon subdivisions,2WTVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
TLS2_k127_1138812_3	391625.PPSIR1_16130	1.656e-14	77.0	COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,42Y58@68525|delta/epsilon subdivisions,2WTVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
TLS2_k127_1140440_0	1340493.JNIF01000003_gene1734	6.624e-210	660.0	COG0104@1|root,COG0104@2|Bacteria,3Y2Z9@57723|Acidobacteria	57723|Acidobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
TLS2_k127_1140440_2	1267535.KB906767_gene1735	3.13e-53	196.0	2BXJ8@1|root,342E7@2|Bacteria,3Y87K@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1140440_1	1340493.JNIF01000003_gene1736	5.06e-73	250.0	COG0016@1|root,COG0016@2|Bacteria,3Y3NJ@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
TLS2_k127_114548_2	234267.Acid_1851	3.447e-63	222.0	COG0642@1|root,COG4252@1|root,COG2205@2|Bacteria,COG4252@2|Bacteria	2|Bacteria	T	Chase2 domain	phoR_2	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HATPase_c,HisKA,PAS_4
TLS2_k127_114548_1	1340493.JNIF01000004_gene732	3.744e-174	556.0	COG2204@1|root,COG2204@2|Bacteria,3Y6FW@57723|Acidobacteria	57723|Acidobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_114548_0	322710.Avin_21270	3.243e-200	634.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tripartite tricarboxylate transporter TctA	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
TLS2_k127_114548_6	1125973.JNLC01000010_gene1418	1.321e-19	94.0	29717@1|root,2ZU9N@2|Bacteria,1ND5N@1224|Proteobacteria,2UHK2@28211|Alphaproteobacteria,3K1BB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
TLS2_k127_114548_3	1038859.AXAU01000001_gene3038	6.694e-63	228.0	COG3181@1|root,COG3181@2|Bacteria	2|Bacteria	E	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
TLS2_k127_114548_5	1038859.AXAU01000004_gene4518	3.898e-35	140.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	marR1	-	-	ko:K06075	-	-	-	-	ko00000,ko03000	-	-	-	HTH_27,MarR,MarR_2
TLS2_k127_114548_4	1379270.AUXF01000007_gene1066	1.521e-59	209.0	COG0318@1|root,COG0318@2|Bacteria,1ZUMN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_1155672_1	1121468.AUBR01000004_gene158	5.961e-67	235.0	COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,24864@186801|Clostridia,42F0X@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
TLS2_k127_1155672_0	1340493.JNIF01000003_gene3319	2.343e-121	396.0	COG1210@1|root,COG1210@2|Bacteria,3Y39W@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Nucleotidyl transferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_1155672_2	1047013.AQSP01000028_gene2077	2.741e-53	197.0	COG0681@1|root,COG0681@2|Bacteria,2NPIA@2323|unclassified Bacteria	2|Bacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS2_k127_1155672_4	56780.SYN_00759	5.457e-26	113.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,42SH8@68525|delta/epsilon subdivisions,2WQ3S@28221|Deltaproteobacteria,2MQNY@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS2_k127_1155672_3	1499967.BAYZ01000009_gene5335	2.444e-51	185.0	COG1690@1|root,COG1690@2|Bacteria,2NNVX@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the RtcB family	rtcB	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
TLS2_k127_116138_1	756272.Plabr_3272	7.469e-55	205.0	COG0642@1|root,COG2199@1|root,COG2202@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,COG3829@2|Bacteria,2IX8Z@203682|Planctomycetes	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.7.65	ko:K13590	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000	-	-	-	BTAD,CHASE3,DUF4118,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
TLS2_k127_116138_3	234267.Acid_1028	1.36e-12	70.0	COG2331@1|root,COG2331@2|Bacteria,3Y92S@57723|Acidobacteria	57723|Acidobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TLS2_k127_116138_0	575540.Isop_1913	7.45e-146	475.0	COG1409@1|root,COG1409@2|Bacteria,2IYSB@203682|Planctomycetes	203682|Planctomycetes	G	Purple acid Phosphatase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
TLS2_k127_116138_2	240016.ABIZ01000001_gene1539	1.256e-24	111.0	COG1520@1|root,COG1520@2|Bacteria,46TV4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_1165158_5	234267.Acid_7362	4.085e-134	434.0	COG1210@1|root,COG1210@2|Bacteria,3Y39W@57723|Acidobacteria	2|Bacteria	M	PFAM Nucleotidyl transferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iIT341.HP0646	NTP_transferase
TLS2_k127_1165158_8	234267.Acid_7361	6.023e-98	337.0	COG1807@1|root,COG1807@2|Bacteria,3Y6PY@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1165158_10	1206744.BAGL01000127_gene7170	8.238e-66	233.0	COG1024@1|root,COG1024@2|Bacteria,2HHR6@201174|Actinobacteria,4FUWW@85025|Nocardiaceae	201174|Actinobacteria	I	enoyl-CoA hydratase	Echdc	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_1165158_6	1267535.KB906767_gene4666	3.227e-129	420.0	COG1087@1|root,COG1087@2|Bacteria,3Y3FK@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS2_k127_1165158_11	1340493.JNIF01000003_gene2260	4.164e-57	206.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.1.1.11	ko:K01051	ko00040,ko01100,map00040,map01100	M00081	R02362	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	CBM_6,Cadherin,DUF1929,HemolysinCabind,Malectin,Metallophos,PA14,Pur_ac_phosph_N
TLS2_k127_1165158_9	1340493.JNIF01000003_gene2685	1.552e-84	289.0	COG1475@1|root,COG1475@2|Bacteria,3Y40Y@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
TLS2_k127_1165158_7	234267.Acid_0016	8.483e-111	363.0	COG1192@1|root,COG1192@2|Bacteria,3Y2Y2@57723|Acidobacteria	57723|Acidobacteria	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS2_k127_1165158_14	546266.NEIMUCOT_05125	3.8e-23	108.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2VR3B@28216|Betaproteobacteria,2KQMA@206351|Neisseriales	206351|Neisseriales	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	gidB	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
TLS2_k127_1165158_2	1267535.KB906767_gene3195	1.599e-299	929.0	COG0445@1|root,COG0445@2|Bacteria,3Y3E4@57723|Acidobacteria,2JHP3@204432|Acidobacteriia	204432|Acidobacteriia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
TLS2_k127_1165158_4	234267.Acid_3564	6.125e-155	500.0	COG1233@1|root,COG3349@1|root,COG1233@2|Bacteria,COG3349@2|Bacteria,3Y3PB@57723|Acidobacteria	57723|Acidobacteria	Q	FAD dependent oxidoreductase	-	-	1.3.5.6	ko:K00514	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R04798,R04800,R07511,R09656,R09658	RC01214,RC01959	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS2_k127_1165158_1	234267.Acid_0987	0.0	1019.0	COG0147@1|root,COG0512@1|root,COG0147@2|Bacteria,COG0512@2|Bacteria,3Y2UX@57723|Acidobacteria	57723|Acidobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K13503,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind,GATase
TLS2_k127_1165158_3	1340493.JNIF01000003_gene4639	6.592e-222	700.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,FAD_oxidored,Fer4,NAD_binding_8,Pyr_redox_2
TLS2_k127_1165158_15	1487953.JMKF01000034_gene1114	6.793e-22	104.0	COG1670@1|root,COG1670@2|Bacteria,1G5DD@1117|Cyanobacteria,1HCAG@1150|Oscillatoriales	1117|Cyanobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS2_k127_1165158_12	204669.Acid345_0174	1.33e-46	170.0	COG0251@1|root,COG0251@2|Bacteria,3Y5DN@57723|Acidobacteria,2JN2R@204432|Acidobacteriia	204432|Acidobacteriia	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
TLS2_k127_1165158_0	1267535.KB906767_gene99	0.0	1149.0	COG0542@1|root,COG0542@2|Bacteria,3Y2X9@57723|Acidobacteria,2JIAE@204432|Acidobacteriia	204432|Acidobacteriia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS2_k127_1169140_6	742725.HMPREF9450_01261	8.93e-42	162.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,4PAMG@976|Bacteroidetes,2FXAJ@200643|Bacteroidia	976|Bacteroidetes	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
TLS2_k127_1169140_1	234267.Acid_2457	3.482e-169	544.0	COG1387@1|root,COG1387@2|Bacteria	2|Bacteria	E	zinc ion binding	polX	-	-	ko:K02347,ko:K04477	-	-	-	-	ko00000,ko03400	-	-	-	HHH_8,PHP
TLS2_k127_1169140_2	309799.DICTH_0508	9.259e-109	364.0	COG2730@1|root,COG2730@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	iLJ478.TM1752	CBM_6,Cellulase
TLS2_k127_1169140_4	278963.ATWD01000001_gene1607	2.57e-63	224.0	COG2353@1|root,COG2353@2|Bacteria,3Y4PV@57723|Acidobacteria,2JMPN@204432|Acidobacteriia	204432|Acidobacteriia	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
TLS2_k127_1169140_5	1267535.KB906767_gene4647	1.143e-51	196.0	COG4449@1|root,COG4449@2|Bacteria,3Y84G@57723|Acidobacteria	57723|Acidobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS2_k127_1169140_0	234267.Acid_1433	2.498e-191	602.0	COG2021@1|root,COG2021@2|Bacteria,3Y4EW@57723|Acidobacteria	57723|Acidobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_1169140_3	234267.Acid_1432	2.489e-84	285.0	COG0500@1|root,COG2226@2|Bacteria,3Y7N3@57723|Acidobacteria	57723|Acidobacteria	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	MetW
TLS2_k127_1172444_0	1340493.JNIF01000003_gene2280	2.37e-233	741.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_1174777_6	521674.Plim_1283	2.848e-05	47.0	COG0673@1|root,COG0673@2|Bacteria,2IX34@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_1174777_3	1501230.ET33_29475	9.533e-11	64.0	2DRAI@1|root,33AYP@2|Bacteria,1U1P7@1239|Firmicutes,4I06Y@91061|Bacilli,273R9@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1174777_4	247490.KSU1_C0549	1.254e-08	58.0	COG3668@1|root,COG3668@2|Bacteria,2J4K7@203682|Planctomycetes	203682|Planctomycetes	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
TLS2_k127_1174777_5	330214.NIDE0652	2.919e-08	59.0	2EC1X@1|root,33GB5@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K21495	-	-	-	-	ko00000,ko02048	-	-	-	-
TLS2_k127_1174777_1	525897.Dbac_0305	2.319e-25	109.0	COG1487@1|root,COG1487@2|Bacteria,1RHQJ@1224|Proteobacteria,42TEC@68525|delta/epsilon subdivisions,2WPE2@28221|Deltaproteobacteria,2MF3R@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_1174777_2	933262.AXAM01000130_gene756	8.417e-22	96.0	2DPZI@1|root,3343T@2|Bacteria,1NPMI@1224|Proteobacteria,42XJN@68525|delta/epsilon subdivisions,2WTE9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1174777_0	391625.PPSIR1_16130	2.791e-64	230.0	COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,42Y58@68525|delta/epsilon subdivisions,2WTVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
TLS2_k127_1186326_0	330214.NIDE2960	7.584e-154	505.0	28H5N@1|root,2Z7I8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1186326_1	118166.JH976538_gene5042	8.041e-66	238.0	COG0845@1|root,COG0845@2|Bacteria,1GCFD@1117|Cyanobacteria,1HF90@1150|Oscillatoriales	1117|Cyanobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1229349_1	1340493.JNIF01000004_gene772	3.917e-230	724.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_1229349_0	886293.Sinac_0947	3.375e-317	999.0	COG2010@1|root,COG2010@2|Bacteria,2IY86@203682|Planctomycetes	203682|Planctomycetes	C	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PSCyt1,PSCyt2,PSD1
TLS2_k127_1229349_2	1340493.JNIF01000004_gene871	1.306e-89	298.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C,TAT_signal
TLS2_k127_1239532_1	1129794.C427_5610	5.107e-22	109.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	signal transduction protein with a C-terminal ATPase domain	-	-	2.7.13.3	ko:K02478,ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase,PocR
TLS2_k127_1239532_0	1198452.Jab_1c13700	2.098e-44	171.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2WEFP@28216|Betaproteobacteria,473DR@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	LytTr DNA-binding domain	algR	-	-	ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
TLS2_k127_1239532_3	1330700.JQNC01000003_gene923	3.146e-05	52.0	COG0744@1|root,COG0744@2|Bacteria,1WIVF@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM Penicillin binding protein transpeptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
TLS2_k127_1239532_2	103690.17134465	1.007e-06	54.0	COG0744@1|root,COG0744@2|Bacteria,1G1XF@1117|Cyanobacteria,1HQZA@1161|Nostocales	1117|Cyanobacteria	M	Transglycosylase	mrcB	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS2_k127_1243810_1	1267535.KB906767_gene4357	9.61e-51	182.0	COG0782@1|root,COG0782@2|Bacteria,3Y351@57723|Acidobacteria,2JKIP@204432|Acidobacteriia	204432|Acidobacteriia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TLS2_k127_124484_2	1267535.KB906767_gene214	5.578e-142	465.0	COG2271@1|root,COG2271@2|Bacteria,3Y638@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_124484_3	1267535.KB906767_gene222	7.71e-126	413.0	COG4948@1|root,COG4948@2|Bacteria,3Y2QQ@57723|Acidobacteria,2JITG@204432|Acidobacteriia	2|Bacteria	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C,MR_MLE_C,MR_MLE_N
TLS2_k127_124484_1	1267535.KB906767_gene217	9.656e-169	532.0	COG3618@1|root,COG3618@2|Bacteria	2|Bacteria	H	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_124484_4	234267.Acid_3529	1.529e-110	364.0	COG0169@1|root,COG0169@2|Bacteria,3Y2Y4@57723|Acidobacteria	57723|Acidobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroD	-	1.1.1.25,4.2.1.10	ko:K00014,ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
TLS2_k127_124484_0	1340493.JNIF01000004_gene558	0.0	1602.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Cytochrom_C,DUF1080,DUF4132,Pkinase
TLS2_k127_124484_5	886293.Sinac_0686	5.467e-101	344.0	28JXN@1|root,2Z9N3@2|Bacteria,2IXIH@203682|Planctomycetes	203682|Planctomycetes	S	PFAM FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
TLS2_k127_124484_7	880070.Cycma_2046	9.179e-73	261.0	COG1921@1|root,COG1921@2|Bacteria,4NIIG@976|Bacteroidetes,47NJD@768503|Cytophagia	976|Bacteroidetes	E	L-seryl-tRNA selenium transferase	-	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,SelA
TLS2_k127_124484_6	1123508.JH636442_gene4178	1.673e-78	279.0	COG1520@1|root,COG1520@2|Bacteria,2IXXG@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TLS2_k127_124484_8	395963.Bind_2543	1.445e-68	242.0	COG2706@1|root,COG2706@2|Bacteria,1R9QR@1224|Proteobacteria,2U4RJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS2_k127_125117_2	234267.Acid_2234	7.869e-167	533.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	aspB1	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS2_k127_125117_1	1267535.KB906767_gene3785	1.017e-249	777.0	COG0034@1|root,COG0034@2|Bacteria,3Y3RG@57723|Acidobacteria,2JHXM@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
TLS2_k127_125117_0	234267.Acid_5944	0.0	1098.0	COG0046@1|root,COG0046@2|Bacteria,3Y30N@57723|Acidobacteria	57723|Acidobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_125117_3	1267535.KB906767_gene3787	6.589e-101	337.0	COG0047@1|root,COG0047@2|Bacteria,3Y2YN@57723|Acidobacteria,2JIBA@204432|Acidobacteriia	204432|Acidobacteriia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
TLS2_k127_125117_6	234267.Acid_6066	3.087e-24	109.0	COG0745@1|root,COG0745@2|Bacteria	234267.Acid_6066|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_125117_5	1267535.KB906767_gene4201	3.426e-67	242.0	COG4251@1|root,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_125117_4	204669.Acid345_2412	9.311e-93	316.0	COG0642@1|root,COG0784@1|root,COG2172@1|root,COG0784@2|Bacteria,COG2172@2|Bacteria,COG2205@2|Bacteria,3Y30Z@57723|Acidobacteria,2JIHG@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
TLS2_k127_1260387_8	1192034.CAP_2034	5.736e-17	87.0	2DR0H@1|root,339NS@2|Bacteria,1R3N7@1224|Proteobacteria,42X1P@68525|delta/epsilon subdivisions,2X8S7@28221|Deltaproteobacteria,2Z3NK@29|Myxococcales	28221|Deltaproteobacteria	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
TLS2_k127_1260387_4	234267.Acid_2182	1.594e-83	289.0	COG0807@1|root,COG0807@2|Bacteria,3Y2I4@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
TLS2_k127_1260387_0	234267.Acid_2181	5.522e-145	472.0	COG2972@1|root,COG2972@2|Bacteria,3Y3NH@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase internal region	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	5TM-5TMR_LYT,HATPase_c,His_kinase
TLS2_k127_1260387_3	234267.Acid_2180	4.469e-91	305.0	COG0500@1|root,COG2226@2|Bacteria,3Y7D3@57723|Acidobacteria	57723|Acidobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_1260387_6	1340493.JNIF01000003_gene2598	4.818e-21	104.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_1260387_1	448385.sce6459	1.345e-135	442.0	COG1228@1|root,COG1228@2|Bacteria,1MY4V@1224|Proteobacteria,4383R@68525|delta/epsilon subdivisions,2X3DQ@28221|Deltaproteobacteria,2YVM1@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_1260387_2	118166.JH976537_gene4259	5.931e-95	317.0	COG3217@1|root,COG3217@2|Bacteria,1G2HY@1117|Cyanobacteria	1117|Cyanobacteria	S	MOSC domain containing protein	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
TLS2_k127_1260387_7	1196029.ALIM01000023_gene726	4.73e-20	94.0	COG4994@1|root,COG4994@2|Bacteria,1VC72@1239|Firmicutes,4HMHY@91061|Bacilli,1ZHVM@1386|Bacillus	91061|Bacilli	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_126804_2	1210884.HG799463_gene10011	3.435e-21	105.0	COG1073@1|root,COG1073@2|Bacteria,2IYEI@203682|Planctomycetes	203682|Planctomycetes	Q	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS2_k127_126804_0	886293.Sinac_6966	1.389e-106	354.0	COG0726@1|root,COG0726@2|Bacteria,2IXYV@203682|Planctomycetes	203682|Planctomycetes	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_126804_1	575540.Isop_0311	2.47e-24	102.0	COG4102@1|root,COG4102@2|Bacteria,2IX5T@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_1272792_5	1340493.JNIF01000003_gene4841	2.356e-31	125.0	COG0582@1|root,COG0582@2|Bacteria,3Y5QQ@57723|Acidobacteria	57723|Acidobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_1272792_3	351627.Csac_0322	1.354e-41	162.0	COG1484@1|root,COG1484@2|Bacteria,1V669@1239|Firmicutes,24I8H@186801|Clostridia,42JCE@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
TLS2_k127_1272792_0	234267.Acid_0647	5.65e-199	631.0	COG4584@1|root,COG4584@2|Bacteria,3Y6WU@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1272792_1	234267.Acid_0648	1.3e-158	511.0	COG1475@1|root,COG1475@2|Bacteria,3Y7ZH@57723|Acidobacteria	57723|Acidobacteria	K	ParB-like nuclease domain	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
TLS2_k127_1272792_6	1267535.KB906767_gene1954	2.488e-20	91.0	2AG8X@1|root,316EB@2|Bacteria,3Y75Y@57723|Acidobacteria,2JNUP@204432|Acidobacteriia	204432|Acidobacteriia	S	Plasmid encoded RepA protein	-	-	-	-	-	-	-	-	-	-	-	-	RepA_C
TLS2_k127_1281287_1	1340493.JNIF01000003_gene2836	3.556e-102	349.0	COG1452@1|root,COG1934@1|root,COG1452@2|Bacteria,COG1934@2|Bacteria,3Y388@57723|Acidobacteria	57723|Acidobacteria	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC,OstA
TLS2_k127_1281287_0	401053.AciPR4_3655	9.72e-118	415.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria,2JI3C@204432|Acidobacteriia	204432|Acidobacteriia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_1281287_2	1267533.KB906740_gene255	2.367e-46	169.0	COG1695@1|root,COG1695@2|Bacteria,3Y510@57723|Acidobacteria,2JJM6@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_1281287_3	1267535.KB906767_gene942	3.614e-22	98.0	COG1629@1|root,COG4771@2|Bacteria,3Y2ZK@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_1281485_3	1286106.MPL1_07598	5.332e-27	119.0	COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RYYR@1236|Gammaproteobacteria,462TJ@72273|Thiotrichales	72273|Thiotrichales	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
TLS2_k127_1281485_0	234267.Acid_5378	2.954e-203	643.0	COG0436@1|root,COG0436@2|Bacteria,3Y6EJ@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class I and II	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_1281485_2	395961.Cyan7425_4661	7.016e-68	237.0	COG2890@1|root,COG2890@2|Bacteria,1G51W@1117|Cyanobacteria,3KJXV@43988|Cyanothece	1117|Cyanobacteria	J	RNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_1281485_4	926554.KI912652_gene4083	3.394e-23	108.0	COG2823@1|root,COG2823@2|Bacteria	2|Bacteria	S	hyperosmotic response	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS2_k127_1281485_1	1267535.KB906767_gene2419	6.141e-194	618.0	COG0439@1|root,COG0439@2|Bacteria,3Y3FH@57723|Acidobacteria,2JKRD@204432|Acidobacteriia	204432|Acidobacteriia	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TLS2_k127_1281485_5	1200792.AKYF01000026_gene163	5.963e-06	57.0	COG4932@1|root,COG4932@2|Bacteria,1UJQY@1239|Firmicutes,4ITDJ@91061|Bacilli,270X3@186822|Paenibacillaceae	91061|Bacilli	M	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_1282658_6	1267535.KB906767_gene4703	4.479e-16	80.0	COG1640@1|root,COG1640@2|Bacteria	2|Bacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.18,2.4.1.25,3.2.1.196,5.4.99.15	ko:K00700,ko:K00705,ko:K02438,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R02110,R02111,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13,GH77	iJN678.malQ	Alpha-amylase,Glyco_hydro_77
TLS2_k127_1282658_8	319225.Plut_1950	2.141e-06	53.0	COG1146@1|root,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	fdxB	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	DUF2703,Fer4,Fer4_4,Fer4_6,Fer4_7
TLS2_k127_1282658_5	234267.Acid_0471	2.674e-29	129.0	COG1193@1|root,COG1193@2|Bacteria,3Y8PZ@57723|Acidobacteria	57723|Acidobacteria	L	Smr domain	-	-	-	-	-	-	-	-	-	-	-	-	Smr
TLS2_k127_1282658_4	1041930.Mtc_1962	2.467e-34	136.0	COG0526@1|root,arCOG01976@2157|Archaea	2157|Archaea	CO	Thiol disulfide interchange protein	-	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	TPR_16,Thioredoxin_2,Thioredoxin_7
TLS2_k127_1282658_1	1120950.KB892784_gene180	7.267e-207	665.0	28IUR@1|root,2Z8TE@2|Bacteria,2I9P5@201174|Actinobacteria,4DPU9@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1282658_3	861299.J421_2051	3.834e-57	206.0	COG1028@1|root,COG1028@2|Bacteria	861299.J421_2051|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1282658_7	370438.PTH_2894	1.964e-09	59.0	COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,24903@186801|Clostridia,261ZB@186807|Peptococcaceae	186801|Clostridia	IQ	PFAM short chain dehydrogenase	kduD	-	1.1.1.127,1.1.1.304,1.1.1.69,1.1.1.76	ko:K00046,ko:K00065,ko:K18009	ko00040,ko00650,map00040,map00650	-	R01542,R03707,R09078,R10505	RC00089,RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
TLS2_k127_1282658_0	1267535.KB906767_gene1045	8.836e-241	752.0	COG0568@1|root,COG0568@2|Bacteria,3Y2XG@57723|Acidobacteria,2JHX1@204432|Acidobacteriia	2|Bacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_1282658_2	234267.Acid_0225	1.948e-120	396.0	COG3522@1|root,COG3522@2|Bacteria,3Y3ZI@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE	-	-	-	ko:K11893	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_VasE
TLS2_k127_1284247_1	768710.DesyoDRAFT_3616	1.837e-38	150.0	COG0437@1|root,COG0437@2|Bacteria,1V8CX@1239|Firmicutes,250DZ@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	ko:K07307	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko02000	5.A.3.3	-	-	Fer4_11,Fer4_4
TLS2_k127_1284247_0	768706.Desor_3577	8.076e-94	335.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,2605J@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5,1.8.5.6	ko:K08352,ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R10149,R11487	RC00168,RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
TLS2_k127_1290090_3	1267535.KB906767_gene552	1.341e-76	289.0	COG1629@1|root,COG4771@2|Bacteria,3Y3Y0@57723|Acidobacteria,2JIYU@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_1290090_2	1183438.GKIL_4354	9.804e-141	476.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_1290090_5	1131814.JAFO01000001_gene1951	2.172e-46	173.0	2D5VR@1|root,32TJX@2|Bacteria,1RJJR@1224|Proteobacteria,2UA3K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1290090_6	391625.PPSIR1_21904	2.275e-27	119.0	COG0640@1|root,COG0640@2|Bacteria,1N8M7@1224|Proteobacteria,42U4R@68525|delta/epsilon subdivisions,2WQ3N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM regulatory protein, ArsR	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
TLS2_k127_1290090_1	344747.PM8797T_14594	2.7e-141	464.0	COG3119@1|root,COG3119@2|Bacteria,2IYRK@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_1290090_4	234267.Acid_4419	1.087e-64	236.0	COG5616@1|root,COG5616@2|Bacteria,3Y9AR@57723|Acidobacteria	57723|Acidobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1290090_0	1340493.JNIF01000003_gene4600	3.085e-178	573.0	COG1629@1|root,COG4771@2|Bacteria,3Y66U@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_1309776_0	452637.Oter_0618	6.717e-213	679.0	COG3591@1|root,COG3591@2|Bacteria,46UUQ@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
TLS2_k127_1309776_4	1121423.JONT01000006_gene2448	2.377e-20	100.0	COG4803@1|root,COG4803@2|Bacteria,1UJ40@1239|Firmicutes,24JIS@186801|Clostridia,267BY@186807|Peptococcaceae	186801|Clostridia	S	membrane protein of uknown function UCP014873	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269,YflT
TLS2_k127_1309776_1	234267.Acid_4939	5.71e-119	388.0	COG2013@1|root,COG2013@2|Bacteria,3Y2XF@57723|Acidobacteria	57723|Acidobacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
TLS2_k127_1309776_7	234267.Acid_2888	0.0003237	50.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,PagL
TLS2_k127_1309776_2	234267.Acid_4062	8.375e-27	128.0	COG3391@1|root,COG4447@1|root,COG3391@2|Bacteria,COG4447@2|Bacteria,3Y31A@57723|Acidobacteria	57723|Acidobacteria	U	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1309776_3	485913.Krac_8577	3.414e-23	117.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	2.7.11.1	ko:K07004,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	ASH,DUF916,FHA,PG_binding_1,Pkinase
TLS2_k127_1309776_5	298654.FraEuI1c_4545	6.618e-12	79.0	COG0515@1|root,COG3391@1|root,COG0515@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,NHL,Pkinase
TLS2_k127_1310818_5	1210908.HSB1_14190	6.324e-58	215.0	COG0179@1|root,arCOG00235@2157|Archaea,2XVAP@28890|Euryarchaeota,23SM4@183963|Halobacteria	183963|Halobacteria	Q	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
TLS2_k127_1310818_1	234267.Acid_7030	3.159e-118	388.0	COG0460@1|root,COG0460@2|Bacteria	2|Bacteria	E	homoserine dehydrogenase activity	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
TLS2_k127_1310818_0	1340493.JNIF01000003_gene4798	3.561e-121	407.0	2EM41@1|root,33ETI@2|Bacteria,3Y97X@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1310818_2	1267535.KB906767_gene1304	1.033e-102	342.0	COG1131@1|root,COG1131@2|Bacteria,3Y394@57723|Acidobacteria,2JINE@204432|Acidobacteriia	204432|Acidobacteriia	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1310818_8	1134445.AJJM01000091_gene3724	2.494e-12	72.0	2DMSR@1|root,32TF3@2|Bacteria,2IR08@201174|Actinobacteria	201174|Actinobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
TLS2_k127_1310818_3	234267.Acid_1540	3.639e-71	248.0	COG4798@1|root,COG4798@2|Bacteria,3Y5JR@57723|Acidobacteria	57723|Acidobacteria	S	Met-10+ like-protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
TLS2_k127_1310818_6	234267.Acid_6444	7.608e-26	117.0	2F776@1|root,33ZNH@2|Bacteria,3Y8A6@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1310818_4	1340493.JNIF01000004_gene177	4.837e-63	229.0	COG1657@1|root,COG3391@1|root,COG1657@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K14647,ko:K21449	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000,ko03110	1.B.40.2	-	-	-
TLS2_k127_1314965_0	1267535.KB906767_gene5437	1.556e-293	920.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,3Y2VV@57723|Acidobacteria,2JIJ7@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA ligase D, 3'-phosphoesterase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS2_k127_1314965_3	234267.Acid_6712	7.392e-48	176.0	COG0736@1|root,COG0736@2|Bacteria,3Y590@57723|Acidobacteria	57723|Acidobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_1314965_2	234267.Acid_6713	1.555e-54	194.0	COG0864@1|root,COG0864@2|Bacteria,3Y83A@57723|Acidobacteria	57723|Acidobacteria	K	NikR C terminal nickel binding domain	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
TLS2_k127_1314965_1	572477.Alvin_2763	7.302e-99	330.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,1WXBT@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
TLS2_k127_1314965_5	234267.Acid_7881	0.0001847	45.0	COG0812@1|root,COG0812@2|Bacteria,3Y3AT@57723|Acidobacteria	57723|Acidobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
TLS2_k127_1320711_4	765420.OSCT_1494	1.173e-07	63.0	2DTK7@1|root,33KQU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1320711_3	1340493.JNIF01000003_gene3585	9.207e-22	98.0	COG2315@1|root,COG2315@2|Bacteria	2|Bacteria	V	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
TLS2_k127_1320711_1	234267.Acid_1440	2.58e-72	253.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	6.5.1.3	ko:K14680	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos_2,RNA_lig_T4_1
TLS2_k127_1320711_2	1123261.AXDW01000004_gene2722	2.84e-57	207.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,1S427@1236|Gammaproteobacteria,1XCFN@135614|Xanthomonadales	135614|Xanthomonadales	J	Acetyltransferase (GNAT) domain	-	-	-	ko:K22479	-	-	-	-	ko00000	-	-	-	Acetyltransf_3
TLS2_k127_1320711_0	1267535.KB906767_gene2309	2.461e-99	332.0	COG0329@1|root,COG0329@2|Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	kdgD	-	4.2.1.41	ko:K01707	ko00053,ko01100,map00053,map01100	-	R02279	RC00678	ko00000,ko00001,ko01000	-	-	-	DHDPS
TLS2_k127_1330987_7	1123242.JH636434_gene3333	1.134e-81	280.0	COG4692@1|root,COG4692@2|Bacteria,2J06F@203682|Planctomycetes	203682|Planctomycetes	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_1330987_1	1340493.JNIF01000004_gene1047	3.431e-250	792.0	COG4654@1|root,COG4654@2|Bacteria	2|Bacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PSCyt1,PSCyt2,PSD1
TLS2_k127_1330987_2	1340493.JNIF01000004_gene1048	3.701e-248	771.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_1330987_10	1267535.KB906767_gene3098	7.836e-44	166.0	COG2823@1|root,COG2823@2|Bacteria,3Y4KR@57723|Acidobacteria,2JJBS@204432|Acidobacteriia	57723|Acidobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS2_k127_1330987_6	234267.Acid_3664	9.169e-113	376.0	COG3214@1|root,COG3214@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS2_k127_1330987_0	1267535.KB906767_gene4353	7.642e-281	870.0	COG0591@1|root,COG0591@2|Bacteria,3Y42K@57723|Acidobacteria,2JI5Z@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
TLS2_k127_1330987_5	1267535.KB906767_gene4351	7.415e-132	434.0	COG0153@1|root,COG0153@2|Bacteria,3Y300@57723|Acidobacteria,2JI7E@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the GHMP kinase family. GalK subfamily	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
TLS2_k127_1330987_9	1410668.JNKC01000005_gene2279	1.292e-68	247.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,36DUP@31979|Clostridiaceae	186801|Clostridia	D	Cell shape determining protein, MreB Mrl family	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TLS2_k127_1330987_11	909663.KI867150_gene882	2.993e-31	127.0	COG0782@1|root,COG0782@2|Bacteria,1MZNY@1224|Proteobacteria,42SYI@68525|delta/epsilon subdivisions,2WPTM@28221|Deltaproteobacteria,2MQJD@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Rnk N-terminus	rnk	-	-	ko:K06140	-	-	-	-	ko00000,ko03000	-	-	-	GreA_GreB,Rnk_N
TLS2_k127_1330987_8	639030.JHVA01000001_gene2859	5.656e-72	255.0	COG4191@1|root,COG4191@2|Bacteria,3Y5DB@57723|Acidobacteria,2JJS0@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_1330987_3	1382359.JIAL01000001_gene2469	1.53e-174	564.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria,2JICQ@204432|Acidobacteriia	204432|Acidobacteriia	T	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_1330987_13	59931.WH7805_06546	1.129e-05	57.0	COG0589@1|root,COG0589@2|Bacteria,1G2NR@1117|Cyanobacteria,1GZHE@1129|Synechococcus	1117|Cyanobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_1330987_4	234267.Acid_7040	6.677e-133	430.0	COG0323@1|root,COG0323@2|Bacteria,3Y2T3@57723|Acidobacteria	57723|Acidobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
TLS2_k127_133327_1	1267534.KB906754_gene3585	9.634e-46	186.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
TLS2_k127_133327_2	931627.MycrhDRAFT_0362	2.573e-11	71.0	COG1917@1|root,COG1917@2|Bacteria,2IRV4@201174|Actinobacteria,23ATB@1762|Mycobacteriaceae	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_133327_0	706587.Desti_2130	1.777e-66	239.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,43AV8@68525|delta/epsilon subdivisions,2X69B@28221|Deltaproteobacteria,2MSKC@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_1334091_2	29581.BW37_04120	1.149e-110	364.0	COG2159@1|root,COG2159@2|Bacteria,1R73N@1224|Proteobacteria,2VQVU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_1334091_1	105559.Nwat_0326	5.834e-137	452.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1X2ND@135613|Chromatiales	135613|Chromatiales	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_8,Sigma54_activat
TLS2_k127_1334091_0	234267.Acid_0778	1.329e-174	560.0	COG2379@1|root,COG2379@2|Bacteria,3Y2XC@57723|Acidobacteria	57723|Acidobacteria	G	MOFRL family	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
TLS2_k127_1334091_3	1340493.JNIF01000003_gene1559	6.461e-13	70.0	COG0703@1|root,COG0703@2|Bacteria,3Y4R0@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI,TMP-TENI
TLS2_k127_133517_2	234267.Acid_1140	7.11e-13	72.0	COG4980@1|root,COG4980@2|Bacteria,3Y8W2@57723|Acidobacteria	57723|Acidobacteria	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
TLS2_k127_133517_0	1267535.KB906767_gene3348	3.082e-220	693.0	COG1012@1|root,COG1012@2|Bacteria,3Y37W@57723|Acidobacteria,2JHJP@204432|Acidobacteriia	204432|Acidobacteriia	C	Delta-1-pyrroline-5-carboxylate dehydrogenase	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS2_k127_133517_1	756272.Plabr_3372	2.688e-128	428.0	COG3119@1|root,COG3119@2|Bacteria,2IX47@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.10.1.1	ko:K01565	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078	R07814	-	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4976,Sulfatase
TLS2_k127_1339372_2	1122939.ATUD01000003_gene3502	5.435e-19	88.0	COG1231@1|root,COG1231@2|Bacteria,2IAZW@201174|Actinobacteria	201174|Actinobacteria	E	Protein of unknown function (DUF1593)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1593
TLS2_k127_1339372_1	1347342.BN863_18240	7.576e-74	268.0	COG2730@1|root,COG2730@2|Bacteria,4PKHG@976|Bacteroidetes,1I0J9@117743|Flavobacteriia	976|Bacteroidetes	G	Protein of unknown function (DUF4038)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
TLS2_k127_1339372_0	1408473.JHXO01000017_gene2952	3.879e-249	781.0	COG5492@1|root,COG5492@2|Bacteria,4NEAB@976|Bacteroidetes	976|Bacteroidetes	N	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF5060
TLS2_k127_134826_7	1267535.KB906767_gene1211	6.467e-14	77.0	2ANB8@1|root,31D9I@2|Bacteria,3Y8WC@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_134826_5	1267535.KB906767_gene1212	1.866e-41	161.0	COG3436@1|root,COG3436@2|Bacteria,3Y875@57723|Acidobacteria	57723|Acidobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
TLS2_k127_134826_1	234267.Acid_2941	1.926e-127	419.0	2DB88@1|root,2Z7QT@2|Bacteria,3Y61J@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
TLS2_k127_134826_0	1267535.KB906767_gene1214	5.632e-182	582.0	COG2433@1|root,COG2433@2|Bacteria,3Y7F1@57723|Acidobacteria	57723|Acidobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
TLS2_k127_134826_6	1267535.KB906767_gene1218	8.046e-27	126.0	2DDV1@1|root,2ZJDR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_134826_2	234267.Acid_6125	1.456e-97	322.0	COG1961@1|root,COG1961@2|Bacteria,3Y5HT@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_7,Resolvase
TLS2_k127_134826_4	1249627.D779_0096	4.918e-43	160.0	2CFP1@1|root,32UTJ@2|Bacteria,1N7ZD@1224|Proteobacteria	1224|Proteobacteria	S	Calcium binding	-	-	-	-	-	-	-	-	-	-	-	-	Calci_bind_CcbP
TLS2_k127_134826_3	485915.Dret_1070	1.334e-59	211.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2MAN7@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
TLS2_k127_1348755_0	331869.BAL199_12636	1.286e-129	423.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
TLS2_k127_1359267_4	509191.AEDB02000080_gene5152	0.0004557	49.0	COG3464@1|root,COG3464@2|Bacteria,1VFE7@1239|Firmicutes,24U01@186801|Clostridia	186801|Clostridia	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1359267_2	1173028.ANKO01000212_gene5076	6.36e-33	142.0	COG0358@1|root,COG0358@2|Bacteria,1G0TV@1117|Cyanobacteria,1H7ZY@1150|Oscillatoriales	1117|Cyanobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_N,zf-CHC2
TLS2_k127_1359267_0	350054.Mflv_4645	8.601e-46	181.0	COG4974@1|root,COG4974@2|Bacteria,2I9ZX@201174|Actinobacteria,2374G@1762|Mycobacteriaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_1359267_1	350058.Mvan_1114	3.607e-34	148.0	COG4974@1|root,COG4974@2|Bacteria,2IBD6@201174|Actinobacteria,236NP@1762|Mycobacteriaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_1359267_3	338966.Ppro_1841	3.904e-11	65.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	2.7.7.49	ko:K00986,ko:K07497	-	-	-	-	ko00000,ko01000	-	-	-	HTH_32,rve,rve_3
TLS2_k127_1362720_0	1122605.KB893637_gene3269	5.745e-185	611.0	COG4692@1|root,COG4692@2|Bacteria	2|Bacteria	G	BNR repeat-like domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,DUF3604,F5_F8_type_C,FIVAR
TLS2_k127_1362720_1	1267535.KB906767_gene1167	2.57e-106	359.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_1363923_3	1500306.JQLA01000003_gene4584	7.09e-35	156.0	COG3920@1|root,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2TVZS@28211|Alphaproteobacteria,4B9IH@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS,PAS_4,PAS_9
TLS2_k127_1363923_0	1267535.KB906767_gene5303	1.376e-169	581.0	COG0642@1|root,COG3829@1|root,COG4251@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE3,GAF,GGDEF,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_1363923_4	1267535.KB906767_gene4811	1.39e-34	141.0	COG0745@1|root,COG0745@2|Bacteria,3Y8QP@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_1363923_1	1267535.KB906767_gene4054	6.209e-84	285.0	COG3279@1|root,COG3279@2|Bacteria,3Y6CD@57723|Acidobacteria	57723|Acidobacteria	T	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
TLS2_k127_1363923_2	1267535.KB906767_gene4055	9.73e-80	275.0	COG2972@1|root,COG2972@2|Bacteria,3Y3NH@57723|Acidobacteria,2JHT4@204432|Acidobacteriia	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
TLS2_k127_1364373_2	234267.Acid_0137	2.118e-40	158.0	COG1595@1|root,COG1595@2|Bacteria,3Y5ME@57723|Acidobacteria	57723|Acidobacteria	K	region 4 type 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_1364373_1	1267535.KB906767_gene4345	5.309e-114	386.0	COG0668@1|root,COG0668@2|Bacteria,3Y6BI@57723|Acidobacteria	57723|Acidobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
TLS2_k127_1364373_0	234267.Acid_2167	3.835e-114	377.0	COG0477@1|root,COG2814@2|Bacteria,3Y47I@57723|Acidobacteria	57723|Acidobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_1364936_1	1120792.JAFV01000001_gene3564	1.473e-30	124.0	COG1573@1|root,COG1573@2|Bacteria,1MW8T@1224|Proteobacteria,2TSAR@28211|Alphaproteobacteria,36YPI@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Uracil DNA glycosylase superfamily	MA20_15960	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4130,UDG
TLS2_k127_1364936_0	1340493.JNIF01000003_gene1414	4.142e-73	256.0	COG2367@1|root,COG2367@2|Bacteria,3Y3UF@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
TLS2_k127_1364936_3	1163407.UU7_09425	2.23e-11	74.0	COG1159@1|root,COG3597@1|root,COG1159@2|Bacteria,COG3597@2|Bacteria,1QXSW@1224|Proteobacteria,1T3I0@1236|Gammaproteobacteria,1X4IJ@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF697)	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	DUF697,MMR_HSR1
TLS2_k127_1364936_2	314230.DSM3645_20202	5.637e-24	104.0	COG1159@1|root,COG1159@2|Bacteria,2J52F@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF697)	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	DUF697,MMR_HSR1
TLS2_k127_1368352_3	234267.Acid_6691	1.244e-57	205.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,3Y2I9@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TLS2_k127_1368352_4	981369.JQMJ01000004_gene2263	3.729e-30	126.0	COG1917@1|root,COG1917@2|Bacteria,2IIQY@201174|Actinobacteria,2NHYR@228398|Streptacidiphilus	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,Cupin_3,SnoaL_2
TLS2_k127_1368352_0	1267535.KB906767_gene2409	1.809e-119	398.0	COG0768@1|root,COG0768@2|Bacteria,3Y3EP@57723|Acidobacteria,2JI45@204432|Acidobacteriia	204432|Acidobacteriia	M	penicillin-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Transpeptidase
TLS2_k127_1368352_1	1340493.JNIF01000003_gene2136	9.116e-114	371.0	COG1028@1|root,COG1028@2|Bacteria,3Y2YB@57723|Acidobacteria	57723|Acidobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_1368352_2	1340493.JNIF01000004_gene333	1.203e-93	316.0	COG0405@1|root,COG0405@2|Bacteria,3Y2N0@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_1373948_1	234267.Acid_7512	6.708e-93	319.0	COG1538@1|root,COG1538@2|Bacteria,3Y54R@57723|Acidobacteria	57723|Acidobacteria	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS2_k127_1373948_3	1267535.KB906767_gene1292	2.084e-16	85.0	COG0628@1|root,COG0628@2|Bacteria	2|Bacteria	D	permease	-	-	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
TLS2_k127_1373948_0	234267.Acid_5660	2.156e-156	505.0	COG0285@1|root,COG0285@2|Bacteria,3Y3ZA@57723|Acidobacteria	57723|Acidobacteria	H	Mur ligase, middle domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
TLS2_k127_1373948_2	1340493.JNIF01000003_gene2985	8.073e-74	257.0	COG0204@1|root,COG0204@2|Bacteria,3Y4EM@57723|Acidobacteria	57723|Acidobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_1384248_0	1340493.JNIF01000004_gene278	4.291e-289	898.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,PD40,PSCyt1,PSCyt2,PSD1,WD40
TLS2_k127_1384248_2	1340493.JNIF01000004_gene277	1.076e-260	808.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_1384248_1	265072.Mfla_1451	1.308e-282	880.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria,2KKUA@206350|Nitrosomonadales	206350|Nitrosomonadales	G	TIGRFAM PQQ-dependent dehydrogenase, methanol ethanol family	-	-	-	-	-	-	-	-	-	-	-	-	PQQ
TLS2_k127_1384248_3	234267.Acid_6910	2.106e-20	94.0	COG2010@1|root,COG2010@2|Bacteria,3Y7WV@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3
TLS2_k127_1388320_13	234267.Acid_5253	7.084e-83	286.0	COG0546@1|root,COG0546@2|Bacteria,3Y4RC@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_1388320_8	234267.Acid_1306	7.159e-117	385.0	COG1629@1|root,COG1629@2|Bacteria,3Y99U@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_1388320_18	234267.Acid_1306	6.302e-47	176.0	COG1629@1|root,COG1629@2|Bacteria,3Y99U@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_1388320_12	234267.Acid_1306	4.071e-84	290.0	COG1629@1|root,COG1629@2|Bacteria,3Y99U@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_1388320_19	234267.Acid_1306	2.713e-44	166.0	COG1629@1|root,COG1629@2|Bacteria,3Y99U@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_1388320_11	1038859.AXAU01000001_gene3942	8.164e-109	367.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2TUQ1@28211|Alphaproteobacteria,3K3JQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_1388320_0	221288.JH992901_gene5058	1.816e-236	769.0	COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria,1JMTM@1189|Stigonemataceae	1117|Cyanobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_1388320_10	1267533.KB906734_gene3885	1.515e-109	359.0	COG2086@1|root,COG2086@2|Bacteria,3Y2PD@57723|Acidobacteria,2JK7K@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
TLS2_k127_1388320_4	1267533.KB906734_gene3884	2.388e-129	425.0	COG2025@1|root,COG2025@2|Bacteria,3Y3JE@57723|Acidobacteria,2JM9U@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein FAD-binding domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TLS2_k127_1388320_17	1095749.HMPREF1052_2173	5.263e-49	190.0	COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,1RS8X@1236|Gammaproteobacteria,1Y7KI@135625|Pasteurellales	135625|Pasteurellales	G	Class II Aldolase and Adducin N-terminal domain	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0019321,GO:0019323,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0071704,GO:1901575	4.1.1.104	ko:K22130	-	-	-	-	ko00000,ko01000	-	-	-	Aldolase_II
TLS2_k127_1388320_16	1340493.JNIF01000004_gene403	3.784e-75	270.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_1388320_21	1267535.KB906767_gene4164	4.82e-17	84.0	COG1722@1|root,COG1722@2|Bacteria,3Y5RT@57723|Acidobacteria	57723|Acidobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
TLS2_k127_1388320_9	1340493.JNIF01000004_gene102	2.971e-115	381.0	COG0142@1|root,COG0142@2|Bacteria,3Y2HS@57723|Acidobacteria	57723|Acidobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_1388320_15	667014.Thein_0763	7.888e-78	267.0	COG1189@1|root,COG1189@2|Bacteria,2GGSK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	FtsJ-like methyltransferase	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
TLS2_k127_1388320_6	1340493.JNIF01000004_gene100	5.49e-120	391.0	COG0061@1|root,COG0061@2|Bacteria,3Y3E6@57723|Acidobacteria	57723|Acidobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
TLS2_k127_1388320_2	234267.Acid_1117	4.109e-170	542.0	COG1301@1|root,COG1301@2|Bacteria,3Y2G6@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	ko:K03309,ko:K11102	-	-	-	-	ko00000,ko02000	2.A.23,2.A.23.1.1,2.A.23.1.2	-	-	SDF
TLS2_k127_1388320_20	1042209.HK44_015750	1.854e-27	117.0	COG0317@1|root,COG0317@2|Bacteria,1N2BZ@1224|Proteobacteria,1SB8N@1236|Gammaproteobacteria,1YQKY@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_4
TLS2_k127_1388320_14	1340493.JNIF01000003_gene1795	2.04e-81	276.0	COG1974@1|root,COG1974@2|Bacteria,3Y47Z@57723|Acidobacteria	57723|Acidobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
TLS2_k127_1388320_22	1267535.KB906767_gene405	3.281e-11	69.0	2DF57@1|root,2ZQIC@2|Bacteria,3Y8V0@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
TLS2_k127_1388320_7	234267.Acid_3379	5.931e-117	386.0	COG0547@1|root,COG0547@2|Bacteria,3Y3YF@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TLS2_k127_1388320_1	1340493.JNIF01000003_gene4821	9.476e-189	595.0	COG0045@1|root,COG0045@2|Bacteria,3Y36X@57723|Acidobacteria	57723|Acidobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
TLS2_k127_1388320_3	234267.Acid_3377	2.757e-146	467.0	COG0074@1|root,COG0074@2|Bacteria,3Y3UX@57723|Acidobacteria	57723|Acidobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
TLS2_k127_1405180_2	234267.Acid_2255	1.87e-45	169.0	COG3618@1|root,COG3618@2|Bacteria,3Y4FF@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_1405180_0	518766.Rmar_0040	1.182e-89	302.0	COG2126@1|root,COG2126@2|Bacteria,4NEX1@976|Bacteroidetes	976|Bacteroidetes	J	Pfam Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
TLS2_k127_1405180_1	1267535.KB906767_gene3595	1.656e-51	193.0	COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria,2JJYF@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS2_k127_1405180_3	1123508.JH636443_gene4588	1.256e-18	92.0	COG4191@1|root,COG4191@2|Bacteria,2IXI7@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_1410848_0	234267.Acid_2382	1.616e-63	237.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	GUN4,TIR_2
TLS2_k127_1410848_1	156889.Mmc1_3173	1.411e-45	175.0	COG3766@1|root,COG3766@2|Bacteria,1Q8XV@1224|Proteobacteria	1224|Proteobacteria	S	Domain of Unknown Function (DUF350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF350
TLS2_k127_1417200_3	234267.Acid_5839	2.205e-24	106.0	COG0477@1|root,COG2814@2|Bacteria,3Y71R@57723|Acidobacteria	57723|Acidobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_1417200_0	1449126.JQKL01000009_gene318	1.228e-258	836.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,267QU@186813|unclassified Clostridiales	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS2_k127_1417200_2	1340493.JNIF01000003_gene4051	6.997e-76	259.0	COG0615@1|root,COG0615@2|Bacteria,3Y5F4@57723|Acidobacteria	57723|Acidobacteria	IM	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
TLS2_k127_1417200_1	234267.Acid_6381	7.045e-127	417.0	COG0859@1|root,COG0859@2|Bacteria,3Y6NF@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TLS2_k127_1420592_3	1340493.JNIF01000003_gene4090	2.72e-06	54.0	COG0860@1|root,COG3227@1|root,COG0860@2|Bacteria,COG3227@2|Bacteria	2|Bacteria	E	Zinc metalloprotease (Elastase)	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783	3.4.24.28,3.5.1.28	ko:K01400,ko:K01417,ko:K01448,ko:K20274	ko01503,ko02024,map01503,map02024	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko03036	-	-	-	Amidase_3,Peptidase_M36
TLS2_k127_1420592_2	634956.Geoth_2436	4.804e-07	57.0	2DE4N@1|root,2ZKGR@2|Bacteria	2|Bacteria	S	Immunity protein 32	-	-	-	-	-	-	-	-	-	-	-	-	Imm32
TLS2_k127_1420592_0	926556.Echvi_3203	6.382e-68	248.0	COG3385@1|root,COG5421@1|root,COG3385@2|Bacteria,COG5421@2|Bacteria,4NXT2@976|Bacteroidetes	976|Bacteroidetes	L	hmm pf01609	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
TLS2_k127_1420592_1	234267.Acid_6462	2.159e-29	120.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_3,PAS_4
TLS2_k127_1423430_6	1452718.JBOY01000053_gene2245	2.151e-11	64.0	2E52W@1|root,32ZW3@2|Bacteria,1RIGH@1224|Proteobacteria,1SDHF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	UPF0158
TLS2_k127_1423430_2	1449044.JMLE01000003_gene2828	5.936e-69	238.0	COG2346@1|root,COG2346@2|Bacteria,2GMG5@201174|Actinobacteria	201174|Actinobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
TLS2_k127_1423430_0	1254432.SCE1572_01300	1.277e-108	353.0	COG4832@1|root,COG4832@2|Bacteria,1RBGY@1224|Proteobacteria,43DQY@68525|delta/epsilon subdivisions,2WZ5Y@28221|Deltaproteobacteria,2Z1E6@29|Myxococcales	28221|Deltaproteobacteria	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
TLS2_k127_1423430_1	365046.Rta_32260	6.634e-73	249.0	COG0346@1|root,COG0346@2|Bacteria,1RD0N@1224|Proteobacteria,2VRUG@28216|Betaproteobacteria,4ADZ0@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_1423430_4	279714.FuraDRAFT_1161	4.108e-54	192.0	COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,2VSQ1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS2_k127_1423430_3	1123279.ATUS01000005_gene3200	4.86e-58	204.0	COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,1S6KT@1236|Gammaproteobacteria,1J74Z@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1428)	ybaA	-	-	-	-	-	-	-	-	-	-	-	DUF1428
TLS2_k127_1423430_5	448385.sce7470	1.432e-34	135.0	COG5552@1|root,COG5552@2|Bacteria,1MZBV@1224|Proteobacteria,4315I@68525|delta/epsilon subdivisions,2WWPX@28221|Deltaproteobacteria,2YVPZ@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
TLS2_k127_144029_2	234267.Acid_4014	1.221e-60	223.0	COG0673@1|root,COG0673@2|Bacteria,3Y4KS@57723|Acidobacteria	2|Bacteria	S	PFAM oxidoreductase domain protein	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_144029_0	670292.JH26_23565	4.944e-72	248.0	COG2514@1|root,COG2514@2|Bacteria,1RBC7@1224|Proteobacteria,2U5JP@28211|Alphaproteobacteria,1JUR8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM Glyoxalase bleomycin resistance protein dioxygenase	catE	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
TLS2_k127_144029_1	1123242.JH636434_gene3868	5.964e-66	243.0	COG1520@1|root,COG1520@2|Bacteria,2IYRB@203682|Planctomycetes	1123242.JH636434_gene3868|-	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1441927_2	314265.R2601_03098	2.064e-60	211.0	COG0395@1|root,COG0395@2|Bacteria,1QQJS@1224|Proteobacteria,2U2UQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type sugar transport system, permease component	-	-	-	ko:K10194	ko02010,map02010	M00202	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.11	-	-	BPD_transp_1
TLS2_k127_1441927_0	1123237.Salmuc_01229	5.451e-157	499.0	COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,2TUDU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type sugar transport systems permease components	-	-	-	ko:K02025,ko:K10193	ko02010,map02010	M00202,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.11	-	-	BPD_transp_1
TLS2_k127_1441927_1	1281779.H009_15967	1.601e-123	404.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1R6B3@1224|Proteobacteria,2U509@28211|Alphaproteobacteria,4BCIE@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	AraC-type DNA-binding domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
TLS2_k127_1441927_3	1073999.BN137_3289	4.912e-23	100.0	COG0693@1|root,COG0693@2|Bacteria,1P4JD@1224|Proteobacteria,1RZ4J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Thij pfpi	yajL_1	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
TLS2_k127_144950_0	111780.Sta7437_1095	2.732e-106	362.0	28M30@1|root,2ZAHC@2|Bacteria,1G4Q0@1117|Cyanobacteria,3VMFI@52604|Pleurocapsales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1449601_1	234267.Acid_5257	4.642e-56	198.0	COG0793@1|root,COG0793@2|Bacteria,3Y3A7@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Peptidase S41	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
TLS2_k127_1449601_0	1340493.JNIF01000003_gene4293	0.0	1338.0	COG1629@1|root,COG4771@2|Bacteria,3Y2ZK@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_1453866_4	1340493.JNIF01000004_gene1197	2.452e-12	69.0	COG0465@1|root,COG0465@2|Bacteria,3Y2UK@57723|Acidobacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798,ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403,M00742	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03019,ko03110,ko04131,ko04147	3.A.16.1	-	-	AAA,Peptidase_M41
TLS2_k127_1453866_0	234267.Acid_6059	3.131e-195	621.0	COG4584@1|root,COG4584@2|Bacteria,3Y630@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_1453866_1	1267535.KB906767_gene3700	6.946e-133	426.0	COG1484@1|root,COG1484@2|Bacteria,3Y4QK@57723|Acidobacteria,2JNWI@204432|Acidobacteriia	204432|Acidobacteriia	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
TLS2_k127_1453866_3	378806.STAUR_1451	6.49e-13	68.0	COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,42N6F@68525|delta/epsilon subdivisions,2WTV5@28221|Deltaproteobacteria,2YZNQ@29|Myxococcales	28221|Deltaproteobacteria	C	Protein of unknown function (DUF561)	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
TLS2_k127_1454841_0	682795.AciX8_2271	7.636e-171	565.0	COG1629@1|root,COG4771@2|Bacteria,3Y368@57723|Acidobacteria,2JKVQ@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_146294_0	234267.Acid_4830	5.221e-89	327.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_146294_1	234267.Acid_3959	9.365e-67	235.0	COG2982@1|root,COG2982@2|Bacteria,3Y2ZX@57723|Acidobacteria	57723|Acidobacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
TLS2_k127_1463904_2	1472716.KBK24_0122690	1.477e-70	243.0	COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2VK11@28216|Betaproteobacteria,1K5KF@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_1463904_0	1267535.KB906767_gene1214	1.671e-169	544.0	COG2433@1|root,COG2433@2|Bacteria,3Y7F1@57723|Acidobacteria	57723|Acidobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
TLS2_k127_1463904_1	234267.Acid_2941	5.209e-100	329.0	2DB88@1|root,2Z7QT@2|Bacteria,3Y61J@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
TLS2_k127_1474957_10	1267535.KB906767_gene216	8.427e-12	71.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS2_k127_1474957_5	234267.Acid_0903	2.318e-77	265.0	COG0233@1|root,COG0233@2|Bacteria,3Y4AP@57723|Acidobacteria	57723|Acidobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
TLS2_k127_1474957_2	1267535.KB906767_gene4503	2.566e-113	370.0	COG0528@1|root,COG0528@2|Bacteria,3Y2FI@57723|Acidobacteria,2JISS@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS2_k127_1474957_4	234267.Acid_0905	2.863e-88	297.0	COG0264@1|root,COG0264@2|Bacteria,3Y3BT@57723|Acidobacteria	57723|Acidobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
TLS2_k127_1474957_1	1340493.JNIF01000004_gene165	2.237e-136	439.0	COG0052@1|root,COG0052@2|Bacteria,3Y3K2@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
TLS2_k127_1474957_7	1267535.KB906767_gene4506	4.393e-56	198.0	COG0103@1|root,COG0103@2|Bacteria,3Y4IK@57723|Acidobacteria,2JJ7P@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
TLS2_k127_1474957_8	234267.Acid_0908	1.252e-53	192.0	COG0102@1|root,COG0102@2|Bacteria,3Y4U5@57723|Acidobacteria	57723|Acidobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
TLS2_k127_1474957_3	240015.ACP_2299	1.155e-105	356.0	COG1215@1|root,COG1215@2|Bacteria,3Y46Y@57723|Acidobacteria,2JIKN@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_1474957_6	414684.RC1_0232	1.2e-67	239.0	COG0204@1|root,COG0204@2|Bacteria,1R787@1224|Proteobacteria,2U4Y1@28211|Alphaproteobacteria,2JW4V@204441|Rhodospirillales	204441|Rhodospirillales	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TLS2_k127_1474957_0	1123508.JH636439_gene1502	1.966e-213	681.0	COG1233@1|root,COG1233@2|Bacteria,2IYPF@203682|Planctomycetes	203682|Planctomycetes	Q	COG1233 Phytoene dehydrogenase and related	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS2_k127_1474957_9	1238182.C882_1170	1.602e-34	139.0	COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,2TR9T@28211|Alphaproteobacteria,2JVAH@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_1477315_0	1403819.BATR01000195_gene6595	2.838e-85	300.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TLS2_k127_1477315_1	288000.BBta_1460	4.951e-44	167.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TLS2_k127_1488362_0	754477.Q7C_1894	5.192e-103	347.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,1RMDF@1236|Gammaproteobacteria,460DW@72273|Thiotrichales	72273|Thiotrichales	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
TLS2_k127_1488362_1	754477.Q7C_1895	1.222e-70	256.0	COG0614@1|root,COG0614@2|Bacteria,1R5IA@1224|Proteobacteria	1224|Proteobacteria	P	Pfam Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS2_k127_1488362_3	1146883.BLASA_1253	2.831e-06	53.0	COG0310@1|root,COG0310@2|Bacteria,2GK2U@201174|Actinobacteria	201174|Actinobacteria	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
TLS2_k127_1488362_2	36875.HQ29_02025	1.632e-43	163.0	COG0310@1|root,COG0310@2|Bacteria	2|Bacteria	P	cobalt ion transport	cbiM	GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072511,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
TLS2_k127_1492008_5	1461693.ATO10_12544	6.55e-72	258.0	COG2091@1|root,COG3321@1|root,COG2091@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,2UR2U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3321 Polyketide synthase modules and related proteins	-	-	-	ko:K04786,ko:K13613	ko01053,map01053	-	-	-	ko00000,ko00001,ko01004,ko01008	-	-	-	ACPS,Acyl_transf_1,Bac_luciferase,Condensation,ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
TLS2_k127_1492008_7	234267.Acid_1974	1.408e-17	90.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS2_k127_1492008_0	234267.Acid_1975	1.266e-169	552.0	COG3379@1|root,COG3379@2|Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_1492008_1	234267.Acid_1976	9.038e-85	293.0	COG0596@1|root,COG0596@2|Bacteria,3Y92K@57723|Acidobacteria	57723|Acidobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_1492008_4	234267.Acid_1979	1.465e-73	261.0	COG4221@1|root,COG4221@2|Bacteria,3Y51J@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_1492008_3	234267.Acid_1979	7.269e-74	261.0	COG4221@1|root,COG4221@2|Bacteria,3Y51J@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_1492008_6	436229.JOEH01000009_gene4447	2.971e-18	97.0	COG0500@1|root,COG2226@2|Bacteria,2IFYW@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	2.1.1.243	ko:K16215	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_25
TLS2_k127_1492008_2	278963.ATWD01000002_gene738	2.884e-77	279.0	COG1629@1|root,COG4771@2|Bacteria,3Y6GR@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_1510420_1	1267534.KB906754_gene3368	3.803e-72	248.0	COG5649@1|root,COG5649@2|Bacteria,3Y4QH@57723|Acidobacteria,2JMZM@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS2_k127_1510420_0	861299.J421_5741	6.7e-103	351.0	COG0596@1|root,COG1228@1|root,COG0596@2|Bacteria,COG1228@2|Bacteria,1ZV1H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_1510420_2	595460.RRSWK_00089	1.175e-67	242.0	COG3119@1|root,COG3119@2|Bacteria,2IXHT@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_1514751_3	211165.AJLN01000107_gene5723	3.16e-33	134.0	28M30@1|root,2ZAHC@2|Bacteria,1G4Q0@1117|Cyanobacteria,1JKI9@1189|Stigonemataceae	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1514751_0	1168034.FH5T_18780	1.972e-192	610.0	COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes,2FQ3G@200643|Bacteroidia	976|Bacteroidetes	P	Arylsulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
TLS2_k127_1514751_2	1121904.ARBP01000002_gene6818	2.831e-135	444.0	COG3119@1|root,COG3119@2|Bacteria,4NETT@976|Bacteroidetes,47U8E@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_1514751_1	700598.Niako_1650	4.178e-169	545.0	28K9B@1|root,2Z9WY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1519999_1	521674.Plim_3329	1.633e-134	437.0	COG1541@1|root,COG1541@2|Bacteria,2IWUR@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1519999_5	163908.KB235896_gene660	1.001e-57	211.0	COG1957@1|root,COG1957@2|Bacteria,1G0NI@1117|Cyanobacteria,1HM1K@1161|Nostocales	1117|Cyanobacteria	F	Inosine-uridine preferring nucleoside hydrolase	-	-	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
TLS2_k127_1519999_2	1267533.KB906734_gene3908	1.814e-121	397.0	COG0266@1|root,COG0266@2|Bacteria,3Y71J@57723|Acidobacteria	57723|Acidobacteria	L	Formamidopyrimidine-DNA glycosylase H2TH domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_1519999_3	1210884.HG799464_gene10536	1.234e-115	381.0	COG1453@1|root,COG1453@2|Bacteria,2IZF3@203682|Planctomycetes	203682|Planctomycetes	S	aldo keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_1519999_4	234267.Acid_0799	7.11e-70	241.0	COG0681@1|root,COG0681@2|Bacteria,3Y49Z@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
TLS2_k127_1519999_6	562970.Btus_0983	6.34e-17	82.0	COG3071@1|root,COG3071@2|Bacteria,1U4Q1@1239|Firmicutes,4IGMA@91061|Bacilli,27AIC@186823|Alicyclobacillaceae	91061|Bacilli	H	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
TLS2_k127_1519999_0	1340493.JNIF01000003_gene3534	5.19e-202	634.0	COG2115@1|root,COG2115@2|Bacteria,3Y841@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the xylose isomerase family	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_1537589_1	234267.Acid_7333	9.88e-35	135.0	COG0128@1|root,COG0128@2|Bacteria,3Y3RH@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TLS2_k127_1537589_0	639030.JHVA01000001_gene2481	5.121e-144	492.0	COG1629@1|root,COG4771@2|Bacteria,3Y3P9@57723|Acidobacteria,2JHUB@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_1540040_4	1123288.SOV_6c00170	2.229e-11	72.0	COG5301@1|root,COG5301@2|Bacteria,1UZU2@1239|Firmicutes,4H69E@909932|Negativicutes	909932|Negativicutes	S	Protein of unknown function (DUF2793)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2793
TLS2_k127_1540040_2	344747.PM8797T_13243	9.371e-28	117.0	COG3682@1|root,COG3682@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
TLS2_k127_1540040_0	344747.PM8797T_13248	3.657e-57	224.0	COG4219@1|root,COG4932@1|root,COG4219@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	DUF3738,Peptidase_M56
TLS2_k127_1540040_1	452637.Oter_4380	7.011e-30	123.0	COG0582@1|root,COG0582@2|Bacteria,46W7E@74201|Verrucomicrobia,3K8J8@414999|Opitutae	414999|Opitutae	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_1540040_3	452637.Oter_4353	1.892e-17	83.0	COG0582@1|root,COG0582@2|Bacteria,46W7E@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_1541074_0	572546.Arcpr_1593	6.867e-181	589.0	COG0380@1|root,arCOG02831@2157|Archaea,2XSTE@28890|Euryarchaeota	28890|Euryarchaeota	G	COG0380 Trehalose-6-phosphate synthase	otsA	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
TLS2_k127_1541074_4	1137799.GZ78_27890	2.055e-09	68.0	2C93F@1|root,2ZVGC@2|Bacteria,1P6MB@1224|Proteobacteria,1SUUR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1541074_3	234267.Acid_4393	1.218e-18	92.0	COG0515@1|root,COG0515@2|Bacteria	234267.Acid_4393|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1541074_2	909663.KI867149_gene3210	1.256e-54	195.0	COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,43ACP@68525|delta/epsilon subdivisions,2WW7Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
TLS2_k127_1541074_1	1293048.CBMB010000003_gene998	6.085e-95	328.0	COG2203@1|root,arCOG03567@1|root,arCOG02369@2157|Archaea,arCOG03567@2157|Archaea,2XUM1@28890|Euryarchaeota,23UN4@183963|Halobacteria	183963|Halobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MEDS
TLS2_k127_1541074_5	1202768.JROF01000030_gene2068	1.995e-05	59.0	COG0737@1|root,arCOG02832@2157|Archaea,2XVHQ@28890|Euryarchaeota,23TQT@183963|Halobacteria	183963|Halobacteria	F	COG0737 5'-nucleotidase 2',3'-cyclic phosphodiesterase and related esterases	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C
TLS2_k127_1543776_3	234267.Acid_7520	1.846e-72	261.0	COG0515@1|root,COG0515@2|Bacteria	234267.Acid_7520|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1543776_0	234267.Acid_7521	0.0	1131.0	COG0768@1|root,COG0772@1|root,COG0768@2|Bacteria,COG0772@2|Bacteria	2|Bacteria	D	peptidoglycan glycosyltransferase activity	pbpA	GO:0002682,GO:0002684,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136	-	ko:K03588,ko:K05364,ko:K05837	ko00550,ko04112,map00550,map04112	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE,Transpeptidase
TLS2_k127_1543776_4	234267.Acid_7522	1.314e-29	130.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	FHA,Guanylate_cyc,Yop-YscD_cpl
TLS2_k127_1543776_5	1340493.JNIF01000003_gene3860	2.966e-23	110.0	2F4SV@1|root,33XFG@2|Bacteria,3Y8BA@57723|Acidobacteria	57723|Acidobacteria	S	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_1543776_1	1340493.JNIF01000003_gene3861	7.906e-108	357.0	COG3781@1|root,COG3781@2|Bacteria,3Y3VN@57723|Acidobacteria	57723|Acidobacteria	S	Bestrophin, RFP-TM, chloride channel	-	-	-	ko:K08994	-	-	-	-	ko00000,ko02000	1.A.46.2	-	-	Bestrophin
TLS2_k127_1543776_2	1340493.JNIF01000003_gene3862	9.507e-96	322.0	COG4191@1|root,COG4191@2|Bacteria,3Y499@57723|Acidobacteria	57723|Acidobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_8
TLS2_k127_1551792_2	1144305.PMI02_01119	8.9e-07	51.0	COG3119@1|root,COG3119@2|Bacteria,1MX3Z@1224|Proteobacteria,2V7VC@28211|Alphaproteobacteria,2K4YT@204457|Sphingomonadales	204457|Sphingomonadales	P	Sulfatase	-	-	3.10.1.1	ko:K01565	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078	R07814	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
TLS2_k127_1551792_1	143224.JQMD01000002_gene121	1.205e-147	482.0	COG3119@1|root,COG3119@2|Bacteria,4NE6V@976|Bacteroidetes,1HZ00@117743|Flavobacteriia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_1551792_0	886293.Sinac_0949	1.018e-191	617.0	COG3250@1|root,COG3250@2|Bacteria,2IWTW@203682|Planctomycetes	203682|Planctomycetes	G	Glycosyl hydrolases family 2	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Glyco_hydro_43
TLS2_k127_1552113_0	234267.Acid_0378	6.893e-68	243.0	COG0859@1|root,COG0859@2|Bacteria,3Y7R7@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
TLS2_k127_1552113_2	1340493.JNIF01000003_gene4260	1.422e-29	123.0	COG4233@1|root,COG4233@2|Bacteria	2|Bacteria	CO	Disulphide bond corrector protein DsbC	dsbD	-	1.8.1.8	ko:K04084,ko:K06888	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
TLS2_k127_1552113_1	1340493.JNIF01000003_gene4261	7.016e-67	232.0	COG0526@1|root,COG0526@2|Bacteria,3Y4K8@57723|Acidobacteria	57723|Acidobacteria	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
TLS2_k127_1559894_0	234267.Acid_2061	8.754e-179	562.0	COG3550@1|root,COG3550@2|Bacteria,3Y4V9@57723|Acidobacteria	57723|Acidobacteria	S	HipA N-terminal domain	-	-	2.7.11.1	ko:K07154	-	-	-	-	ko00000,ko01000,ko01001,ko02048	-	-	-	Couple_hipA,HipA_C
TLS2_k127_1559894_2	1034943.BN1094_02953	1.196e-17	85.0	COG1396@1|root,COG1396@2|Bacteria,1NGFD@1224|Proteobacteria,1SGW1@1236|Gammaproteobacteria,1JF1Q@118969|Legionellales	118969|Legionellales	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19
TLS2_k127_1559894_3	112098.XP_008607517.1	0.0002383	48.0	COG0484@1|root,KOG0712@2759|Eukaryota	2759|Eukaryota	O	heat shock protein binding	-	-	-	ko:K09503	ko04141,map04141	-	-	-	ko00000,ko00001,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_1559894_1	234267.Acid_7844	8.534e-92	305.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,3Y2VV@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase LigD, ligase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS2_k127_1568792_0	234267.Acid_1776	2.603e-145	498.0	COG1629@1|root,COG4771@2|Bacteria,3Y2WI@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_1568792_1	497964.CfE428DRAFT_2899	2.843e-89	305.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_1568792_2	497964.CfE428DRAFT_2900	2.919e-16	84.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_1576279_1	1267535.KB906767_gene4261	3.038e-137	448.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	ilvX	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0030312,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
TLS2_k127_1576279_0	234267.Acid_5325	7.9e-228	711.0	COG0673@1|root,COG0673@2|Bacteria,3Y7B1@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_1576279_2	497964.CfE428DRAFT_2876	2.671e-79	268.0	COG2818@1|root,COG2818@2|Bacteria,46SS9@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
TLS2_k127_1576279_4	1206720.BAFQ01000297_gene6658	2.241e-27	124.0	2DMMQ@1|root,32SHK@2|Bacteria,2IHWW@201174|Actinobacteria,4G2S5@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3052
TLS2_k127_1576279_3	1340493.JNIF01000003_gene4244	5.829e-52	190.0	2ANK7@1|root,31DJB@2|Bacteria,3Y7J7@57723|Acidobacteria	57723|Acidobacteria	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
TLS2_k127_157746_1	886293.Sinac_3304	3.904e-78	275.0	COG4102@1|root,COG4102@2|Bacteria,2IXDD@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_157746_0	756272.Plabr_3328	8.494e-151	499.0	COG5492@1|root,COG5492@2|Bacteria,2IXP9@203682|Planctomycetes	203682|Planctomycetes	N	Protein of unknown function (DUF1549)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt2,PSD1
TLS2_k127_15846_0	1340493.JNIF01000003_gene4171	4.743e-127	421.0	COG4206@1|root,COG4206@2|Bacteria,3Y3IJ@57723|Acidobacteria	57723|Acidobacteria	H	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_15846_1	234267.Acid_7892	2.499e-99	338.0	COG1721@1|root,COG1721@2|Bacteria,3Y5V9@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_15846_2	639030.JHVA01000001_gene2644	1.68e-17	86.0	COG4770@1|root,COG4770@2|Bacteria,3Y5QJ@57723|Acidobacteria,2JN6E@204432|Acidobacteriia	204432|Acidobacteriia	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
TLS2_k127_160679_1	1198114.AciX9_3113	6.708e-15	79.0	2BJ7N@1|root,32DH4@2|Bacteria,3Y8SI@57723|Acidobacteria	57723|Acidobacteria	S	FRG	-	-	-	-	-	-	-	-	-	-	-	-	FRG
TLS2_k127_160679_0	234267.Acid_2879	5.272e-21	107.0	COG4386@1|root,COG4386@2|Bacteria,3Y76B@57723|Acidobacteria	57723|Acidobacteria	S	tail sheath protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1607587_3	1280944.HY17_18820	1.867e-08	65.0	2DR6B@1|root,33ACQ@2|Bacteria,1NI4T@1224|Proteobacteria,2UKEW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1607587_2	1267535.KB906767_gene2117	1.665e-137	446.0	COG0624@1|root,COG0624@2|Bacteria,3Y2K0@57723|Acidobacteria,2JIEY@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM peptidase	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_1607587_1	1267535.KB906767_gene2118	1.764e-162	518.0	COG0136@1|root,COG0136@2|Bacteria,3Y346@57723|Acidobacteria,2JHXJ@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the aspartate-semialdehyde dehydrogenase family	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_1607587_0	234267.Acid_6982	1.477e-185	590.0	COG0527@1|root,COG0527@2|Bacteria,3Y34W@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT
TLS2_k127_160839_0	1267535.KB906767_gene3023	1.368e-175	557.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
TLS2_k127_160839_2	1366050.N234_10280	8.876e-30	126.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2VZ53@28216|Betaproteobacteria,1K5YJ@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Elongation factor P	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TLS2_k127_160839_1	234267.Acid_5339	6.047e-96	319.0	COG1131@1|root,COG1131@2|Bacteria,3Y3U0@57723|Acidobacteria	57723|Acidobacteria	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1614737_0	1267535.KB906767_gene5227	2.539e-113	383.0	COG0025@1|root,COG0025@2|Bacteria	2|Bacteria	P	sodium:proton antiporter activity	-	-	3.1.3.16	ko:K06382	-	-	-	-	ko00000,ko01000	-	-	-	Na_H_Exchanger
TLS2_k127_1614737_1	1267535.KB906767_gene5226	3.965e-43	165.0	COG0475@1|root,COG0475@2|Bacteria	2|Bacteria	P	glutathione-regulated potassium exporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS2_k127_1614737_2	1232410.KI421415_gene3074	8.464e-16	78.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,43S5M@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	helicase superfamily c-terminal domain	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C,R3H
TLS2_k127_1625259_3	234267.Acid_7573	4.721e-98	330.0	COG1629@1|root,COG4771@2|Bacteria,3Y6Q2@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_1625259_1	234267.Acid_7937	9.344e-132	422.0	COG1136@1|root,COG1136@2|Bacteria,3Y30Q@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1625259_0	234267.Acid_7936	1.673e-173	557.0	COG1566@1|root,COG1566@2|Bacteria,3Y9B7@57723|Acidobacteria	57723|Acidobacteria	V	Biotin-lipoyl like	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
TLS2_k127_1625259_2	1267535.KB906767_gene1738	9.327e-124	417.0	COG3829@1|root,COG3829@2|Bacteria,3Y6K2@57723|Acidobacteria	57723|Acidobacteria	KT	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat,Yop-YscD_cpl
TLS2_k127_162887_3	1340493.JNIF01000003_gene2166	1.571e-67	239.0	COG1629@1|root,COG4771@2|Bacteria,3Y36T@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_162887_1	306281.AJLK01000118_gene4068	3.94e-123	402.0	COG0604@1|root,COG0604@2|Bacteria,1G241@1117|Cyanobacteria,1JHGA@1189|Stigonemataceae	1117|Cyanobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_162887_4	234267.Acid_5564	8.353e-33	136.0	COG2968@1|root,COG2968@2|Bacteria,3Y844@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
TLS2_k127_162887_5	1267535.KB906767_gene415	1.029e-30	125.0	COG1366@1|root,COG1366@2|Bacteria,3Y4U6@57723|Acidobacteria,2JJH2@204432|Acidobacteriia	204432|Acidobacteriia	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS2_k127_162887_0	234267.Acid_7044	1.586e-125	415.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,3Y4NJ@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07640	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_162887_2	234267.Acid_7043	1.215e-97	324.0	COG0745@1|root,COG0745@2|Bacteria,3Y4IJ@57723|Acidobacteria	57723|Acidobacteria	T	PFAM response regulator receiver	-	-	-	ko:K07662	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_1629576_4	1340493.JNIF01000003_gene1364	1.503e-31	126.0	COG3137@1|root,COG3137@2|Bacteria,3Y380@57723|Acidobacteria	57723|Acidobacteria	M	Protein of unknown function, DUF481	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
TLS2_k127_1629576_3	448385.sce6671	3.292e-45	172.0	COG3409@1|root,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	3.5.1.28	ko:K01447,ko:K07126,ko:K13582	ko04112,map04112	-	R04112	RC00064,RC00141	ko00000,ko00001,ko01000	-	-	-	LysM,PG_binding_1,Sel1
TLS2_k127_1629576_2	118168.MC7420_4621	7.502e-54	215.0	COG1193@1|root,COG1193@2|Bacteria,1G4EJ@1117|Cyanobacteria,1H726@1150|Oscillatoriales	1117|Cyanobacteria	L	Protein-arginine deiminase (PAD)	-	-	3.5.3.15	ko:K01481	-	-	-	-	ko00000,ko01000	-	-	-	PAD,PAD_M
TLS2_k127_1629576_6	379066.GAU_0801	4.994e-07	61.0	COG1413@1|root,COG4219@1|root,COG1413@2|Bacteria,COG4219@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,Peptidase_M56
TLS2_k127_1629576_0	1267535.KB906767_gene713	2.475e-215	680.0	COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria,2JI4Q@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS2_k127_1629576_5	373994.Riv7116_3219	6.308e-27	119.0	2DKWD@1|root,30KRK@2|Bacteria,1G3BN@1117|Cyanobacteria	1117|Cyanobacteria	S	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
TLS2_k127_1629576_1	247490.KSU1_C1712	2.827e-116	391.0	2DBP2@1|root,2ZA71@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1631557_4	1340493.JNIF01000003_gene1648	2.094e-58	207.0	COG0649@1|root,COG0649@2|Bacteria,3Y3N1@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
TLS2_k127_1631557_3	234267.Acid_0112	3.933e-71	246.0	COG1905@1|root,COG1905@2|Bacteria,3Y4SI@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM NADH-quinone oxidoreductase, E subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
TLS2_k127_1631557_1	234267.Acid_0113	1.359e-218	685.0	COG1894@1|root,COG1894@2|Bacteria,3Y2NM@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
TLS2_k127_1631557_0	1267535.KB906767_gene4284	7.1e-308	958.0	COG3383@1|root,COG3383@2|Bacteria,3Y2T6@57723|Acidobacteria,2JIAG@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_10,Fer4_6,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
TLS2_k127_1631557_2	1340493.JNIF01000003_gene1644	8.27e-175	555.0	COG1005@1|root,COG1005@2|Bacteria,3Y3VS@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS2_k127_1631557_5	1267535.KB906767_gene4286	2.373e-56	201.0	COG0839@1|root,COG0839@2|Bacteria,3Y4I4@57723|Acidobacteria,2JJ8B@204432|Acidobacteriia	204432|Acidobacteriia	C	plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS2_k127_1631557_6	1340493.JNIF01000003_gene1642	2.857e-41	153.0	COG0713@1|root,COG0713@2|Bacteria,3Y4XI@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS2_k127_1631650_1	234267.Acid_1808	1.709e-181	581.0	COG4206@1|root,COG4206@2|Bacteria,3Y30M@57723|Acidobacteria	57723|Acidobacteria	H	TonB-dependent Receptor Plug	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TLS2_k127_1631650_4	1047013.AQSP01000142_gene196	1.22e-07	59.0	2EFWM@1|root,339NX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1631650_0	234267.Acid_7922	2.816e-248	777.0	COG1215@1|root,COG1215@2|Bacteria,3Y31I@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
TLS2_k127_1631650_2	448385.sce2886	3.518e-53	195.0	COG0702@1|root,COG0702@2|Bacteria,1MZG7@1224|Proteobacteria,42UCW@68525|delta/epsilon subdivisions,2WQWQ@28221|Deltaproteobacteria,2YV6G@29|Myxococcales	28221|Deltaproteobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
TLS2_k127_1631650_3	1340493.JNIF01000004_gene396	1.433e-27	113.0	COG1028@1|root,COG1028@2|Bacteria	1340493.JNIF01000004_gene396|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1632948_1	234267.Acid_3848	3.438e-117	383.0	COG1132@1|root,COG1132@2|Bacteria,3Y32T@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
TLS2_k127_1632948_0	639030.JHVA01000001_gene1886	4.457e-201	664.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_1633702_0	234267.Acid_6186	4.691e-242	764.0	COG2010@1|root,COG2010@2|Bacteria,3Y6T1@57723|Acidobacteria	57723|Acidobacteria	C	cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_1633702_1	234267.Acid_6187	7.526e-197	622.0	COG4102@1|root,COG4102@2|Bacteria,3Y6RN@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_1633859_5	1267535.KB906767_gene3251	4.916e-113	371.0	COG2271@1|root,COG2271@2|Bacteria,3Y2KA@57723|Acidobacteria,2JI0V@204432|Acidobacteriia	204432|Acidobacteriia	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
TLS2_k127_1633859_7	667014.Thein_1982	2.733e-92	325.0	COG0569@1|root,COG0569@2|Bacteria,2GIEN@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Alanine dehydrogenase/PNT, C-terminal domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS2_k127_1633859_2	1307759.JOMJ01000003_gene1044	5.554e-130	432.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria,2M8CP@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS2_k127_1633859_8	234267.Acid_7305	4.258e-83	289.0	COG0796@1|root,COG0796@2|Bacteria,3Y4CB@57723|Acidobacteria	57723|Acidobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
TLS2_k127_1633859_10	290397.Adeh_2563	2.725e-31	139.0	2F8HZ@1|root,340WS@2|Bacteria,1NJHM@1224|Proteobacteria,430Z9@68525|delta/epsilon subdivisions,2WVPE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1633859_6	269797.Mbar_A0375	4.012e-97	332.0	COG0438@1|root,arCOG05174@2157|Archaea,2XX01@28890|Euryarchaeota,2N9IX@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
TLS2_k127_1633859_9	1122919.KB905549_gene2052	1.06e-65	238.0	COG0438@1|root,COG0438@2|Bacteria,1UZZ8@1239|Firmicutes,4IAWI@91061|Bacilli,2739V@186822|Paenibacillaceae	91061|Bacilli	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
TLS2_k127_1633859_4	234267.Acid_1019	4.308e-115	379.0	COG1089@1|root,COG1089@2|Bacteria,3Y3QZ@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_1633859_3	926566.Terro_1167	5.725e-120	401.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS2_k127_1633859_1	926566.Terro_1166	5.47e-132	434.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cvaA	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,OEP
TLS2_k127_1633859_0	1242864.D187_003297	5.858e-158	522.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,43BXM@68525|delta/epsilon subdivisions	1224|Proteobacteria	V	Peptidase C39 family	-	-	-	ko:K12541	ko02010,map02010	M00330	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.3,3.A.1.109.4	-	-	ABC_membrane,ABC_tran,Peptidase_C39
TLS2_k127_1633859_11	1122165.AUHS01000015_gene749	1.695e-26	118.0	COG0640@1|root,COG0640@2|Bacteria,1QCA7@1224|Proteobacteria,1T7ZW@1236|Gammaproteobacteria,1JG33@118969|Legionellales	118969|Legionellales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1633859_12	1210045.ALNP01000003_gene4237	1.801e-11	70.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway	-	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_1640279_3	1340493.JNIF01000004_gene768	6.638e-90	299.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_1640279_6	204669.Acid345_1931	1.059e-47	175.0	COG2080@1|root,COG2080@2|Bacteria,3Y5EJ@57723|Acidobacteria,2JN23@204432|Acidobacteriia	204432|Acidobacteriia	C	[2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Fer2_2
TLS2_k127_1640279_2	1267533.KB906738_gene2186	7.898e-217	693.0	COG1529@1|root,COG1529@2|Bacteria,3Y3J7@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C2
TLS2_k127_1640279_5	1340493.JNIF01000003_gene4459	1.611e-69	239.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	tdcF2	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
TLS2_k127_1640279_0	1340493.JNIF01000003_gene3118	0.0	1521.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Dioxygenase_C,Plug,TonB_dep_Rec
TLS2_k127_1640279_1	471854.Dfer_2454	6.411e-270	842.0	COG2936@1|root,COG2936@2|Bacteria,4NFFB@976|Bacteroidetes,47JKV@768503|Cytophagia	976|Bacteroidetes	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
TLS2_k127_1640279_7	1340493.JNIF01000004_gene780	1.62e-34	137.0	COG0251@1|root,COG0251@2|Bacteria,3Y4PU@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS2_k127_1640279_4	1340493.JNIF01000003_gene4759	4.519e-70	246.0	COG2355@1|root,COG2355@2|Bacteria,3Y3RS@57723|Acidobacteria	57723|Acidobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
TLS2_k127_1640643_3	1403313.AXBR01000022_gene2869	2.798e-05	48.0	COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,4HGY6@91061|Bacilli,1ZERT@1386|Bacillus	91061|Bacilli	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_1640643_0	234267.Acid_7603	4.613e-132	427.0	2AG8X@1|root,316EB@2|Bacteria,3Y75Y@57723|Acidobacteria	57723|Acidobacteria	S	Plasmid encoded RepA protein	-	-	-	-	-	-	-	-	-	-	-	-	RepA_C
TLS2_k127_1640643_2	1173029.JH980292_gene2592	4.218e-29	120.0	COG1848@1|root,COG1848@2|Bacteria,1G6FV@1117|Cyanobacteria,1HBMX@1150|Oscillatoriales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_1640643_1	1210884.HG799463_gene10011	1.202e-60	225.0	COG1073@1|root,COG1073@2|Bacteria,2IYEI@203682|Planctomycetes	203682|Planctomycetes	Q	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS2_k127_1644741_11	1395571.TMS3_0101195	3.525e-15	77.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006482,GO:0006807,GO:0006935,GO:0008150,GO:0008152,GO:0008214,GO:0008984,GO:0009605,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0018277,GO:0019538,GO:0019899,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051723,GO:0052689,GO:0070988,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1990827	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
TLS2_k127_1644741_3	234267.Acid_6728	3.788e-193	610.0	COG1914@1|root,COG1914@2|Bacteria,3Y3EU@57723|Acidobacteria	57723|Acidobacteria	P	PFAM natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
TLS2_k127_1644741_5	234267.Acid_6727	2.435e-150	486.0	COG2239@1|root,COG2239@2|Bacteria,3Y3WD@57723|Acidobacteria	57723|Acidobacteria	P	MgtE intracellular	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N
TLS2_k127_1644741_0	234267.Acid_7720	4.242e-239	747.0	COG0064@1|root,COG0064@2|Bacteria,3Y2TJ@57723|Acidobacteria	57723|Acidobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
TLS2_k127_1644741_6	234267.Acid_7321	3.388e-76	290.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1644741_13	47763.JNZA01000015_gene720	1.438e-10	76.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria	201174|Actinobacteria	M	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Cytochrom_D1,Lactonase
TLS2_k127_1644741_1	234267.Acid_4088	4.59e-217	709.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS2_k127_1644741_12	153496.JNAB01000023_gene2417	2.448e-11	68.0	2DQNQ@1|root,337TP@2|Bacteria,1NFYG@1224|Proteobacteria,2UFD8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1644741_10	1267535.KB906767_gene1333	1.209e-20	96.0	COG0745@1|root,COG0745@2|Bacteria,3Y8Y3@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_1644741_7	1340493.JNIF01000004_gene473	4.42e-58	211.0	2CFSQ@1|root,32S2E@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1644741_8	1267535.KB906767_gene5111	5.858e-40	151.0	COG0001@1|root,COG0001@2|Bacteria,3Y3GA@57723|Acidobacteria,2JINJ@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_1644741_4	1340493.JNIF01000003_gene1346	1.001e-153	490.0	COG0001@1|root,COG0001@2|Bacteria,3Y3GA@57723|Acidobacteria	57723|Acidobacteria	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_1644741_2	1267535.KB906767_gene4972	7.965e-208	655.0	COG1132@1|root,COG1132@2|Bacteria,3Y452@57723|Acidobacteria,2JKH2@204432|Acidobacteriia	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
TLS2_k127_1650795_1	448385.sce0716	9.515e-123	403.0	COG0520@1|root,COG0520@2|Bacteria,1R4SM@1224|Proteobacteria	1224|Proteobacteria	M	Class V aminotransferase	-	-	5.1.1.17	ko:K04127	ko00311,ko01100,ko01130,map00311,map01100,map01130	M00673	R04147	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
TLS2_k127_1650795_0	1267535.KB906767_gene3199	2.571e-225	712.0	COG3250@1|root,COG3250@2|Bacteria,3Y48R@57723|Acidobacteria,2JKSM@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyl hydrolases family 2, TIM barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glyco_hydro_2_N
TLS2_k127_1650795_3	472759.Nhal_1438	2.013e-37	147.0	COG0745@1|root,COG0745@2|Bacteria,1RD6H@1224|Proteobacteria,1T2RG@1236|Gammaproteobacteria,1X15Y@135613|Chromatiales	135613|Chromatiales	T	cheY-homologous receiver domain	-	-	-	ko:K02485	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg
TLS2_k127_1650795_2	234267.Acid_0380	1.263e-53	195.0	COG1502@1|root,COG1502@2|Bacteria,3Y2GD@57723|Acidobacteria	57723|Acidobacteria	I	PLD-like domain	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
TLS2_k127_1653753_0	234267.Acid_1154	2.513e-76	272.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_1653753_2	1121920.AUAU01000008_gene1645	9.257e-29	120.0	COG2010@1|root,COG2010@2|Bacteria,3Y5Q0@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS2_k127_1653753_1	1340493.JNIF01000003_gene3700	2.177e-50	180.0	COG0673@1|root,COG0673@2|Bacteria,3Y6C9@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_1654658_6	234267.Acid_7316	3.272e-90	301.0	COG0769@1|root,COG0769@2|Bacteria,3Y38W@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_1654658_2	234267.Acid_7315	4.971e-159	512.0	COG0770@1|root,COG0770@2|Bacteria,3Y3I2@57723|Acidobacteria	57723|Acidobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_1654658_1	1340493.JNIF01000003_gene3728	2.842e-171	544.0	COG0472@1|root,COG0472@2|Bacteria,3Y2ZH@57723|Acidobacteria	57723|Acidobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
TLS2_k127_1654658_3	1267535.KB906767_gene2563	1.659e-136	452.0	COG0771@1|root,COG0771@2|Bacteria,3Y2JK@57723|Acidobacteria,2JHQF@204432|Acidobacteriia	204432|Acidobacteriia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_1654658_4	1267535.KB906767_gene2562	2.794e-133	434.0	COG0772@1|root,COG0772@2|Bacteria,3Y330@57723|Acidobacteria,2JHW0@204432|Acidobacteriia	204432|Acidobacteriia	D	Belongs to the SEDS family	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
TLS2_k127_1654658_5	234267.Acid_7311	4.122e-117	389.0	COG0707@1|root,COG0707@2|Bacteria,3Y48B@57723|Acidobacteria	57723|Acidobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
TLS2_k127_1654658_0	234267.Acid_7310	4.88e-212	667.0	COG0773@1|root,COG0773@2|Bacteria,3Y304@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_1654984_4	63737.Npun_R3023	2.172e-12	72.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
TLS2_k127_1654984_0	663610.JQKO01000001_gene1028	8.583e-121	400.0	COG0577@1|root,COG0577@2|Bacteria,1P0WE@1224|Proteobacteria,2VG3S@28211|Alphaproteobacteria,3NBZM@45404|Beijerinckiaceae	28211|Alphaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_1654984_1	1123242.JH636435_gene2326	2.897e-84	287.0	COG1136@1|root,COG1136@2|Bacteria,2IYS3@203682|Planctomycetes	203682|Planctomycetes	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1654984_2	1123508.JH636439_gene960	5.538e-72	258.0	COG0845@1|root,COG0845@2|Bacteria,2IYUX@203682|Planctomycetes	203682|Planctomycetes	M	PFAM secretion protein HlyD	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TLS2_k127_1654984_3	404380.Gbem_1397	8.156e-39	155.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS2_k127_1656888_4	1562701.BBOF01000076_gene133	8.398e-69	239.0	COG3464@1|root,COG3464@2|Bacteria,1MX7Z@1224|Proteobacteria,2W2AT@28216|Betaproteobacteria,1KA1J@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1656888_2	234267.Acid_2874	1.462e-101	341.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
TLS2_k127_1656888_5	234267.Acid_2608	4.187e-58	209.0	COG1661@1|root,COG1661@2|Bacteria	2|Bacteria	O	DNA-binding protein with PD1-like DNA-binding motif	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296,Glutaredoxin
TLS2_k127_1656888_3	1123508.JH636439_gene1117	2.113e-85	292.0	COG3391@1|root,COG3391@2|Bacteria,2J2IQ@203682|Planctomycetes	203682|Planctomycetes	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
TLS2_k127_1656888_0	1267535.KB906767_gene3524	3.965e-316	1003.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_1656888_1	1340493.JNIF01000003_gene4574	2.339e-161	520.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_166295_1	861299.J421_2157	7.401e-134	465.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,1ZUXK@142182|Gemmatimonadetes	2|Bacteria	T	AAA ATPase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,Trans_reg_C
TLS2_k127_166295_0	1385519.N801_11710	2.68e-139	464.0	COG0671@1|root,COG0671@2|Bacteria,2I8WW@201174|Actinobacteria	2|Bacteria	I	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,PAP2
TLS2_k127_1666734_0	234267.Acid_3341	1.461e-218	704.0	COG1629@1|root,COG4771@2|Bacteria,3Y3HY@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_166807_2	682795.AciX8_3506	5.45e-126	422.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,Cellulase,Glyco_hydro_2_C,Glyco_hydro_42,Glycos_transf_2
TLS2_k127_166807_1	234267.Acid_1915	1.685e-208	663.0	COG0539@1|root,COG0539@2|Bacteria,3Y3P3@57723|Acidobacteria	57723|Acidobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
TLS2_k127_166807_0	562970.Btus_2112	1.021e-239	760.0	COG3256@1|root,COG3256@2|Bacteria,1TSW2@1239|Firmicutes,4HCFR@91061|Bacilli,279NB@186823|Alicyclobacillaceae	91061|Bacilli	P	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
TLS2_k127_1674184_1	1340493.JNIF01000004_gene375	1.71e-36	149.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
TLS2_k127_1674184_0	234267.Acid_0997	1.239e-137	444.0	COG0318@1|root,COG0318@2|Bacteria	2|Bacteria	IQ	PFAM AMP-dependent synthetase and ligase	fadD36	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0051087	-	ko:K12429,ko:K18660,ko:K18661,ko:K18662	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_1678735_1	246197.MXAN_3779	3.55e-237	770.0	COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1MU6G@1224|Proteobacteria	1224|Proteobacteria	IQ	COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Bac_luciferase,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,Methyltransf_25,PP-binding,Thioesterase,ketoacyl-synt
TLS2_k127_1678735_0	1173027.Mic7113_2129	0.0	1056.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H6ZY@1150|Oscillatoriales	1117|Cyanobacteria	Q	non-ribosomal peptide synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_11,Methyltransf_12,Methyltransf_25,Methyltransf_31,PP-binding,Thioesterase
TLS2_k127_168306_1	234267.Acid_4153	1.327e-124	413.0	COG1538@1|root,COG1538@2|Bacteria,3Y5F3@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS2_k127_168306_2	234267.Acid_4152	2.306e-95	329.0	COG0845@1|root,COG0845@2|Bacteria,3Y4YK@57723|Acidobacteria	57723|Acidobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TLS2_k127_168306_0	234267.Acid_4151	0.0	1415.0	COG0841@1|root,COG0841@2|Bacteria,3Y2SK@57723|Acidobacteria	57723|Acidobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TLS2_k127_168306_4	234267.Acid_4150	1.736e-19	94.0	COG0607@1|root,32YCZ@2|Bacteria,3Y5Z1@57723|Acidobacteria	57723|Acidobacteria	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
TLS2_k127_168306_3	1218076.BAYB01000008_gene1507	9.052e-62	225.0	COG2197@1|root,COG3899@1|root,COG2197@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,1JZT2@119060|Burkholderiaceae	28216|Betaproteobacteria	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Guanylate_cyc,Pkinase,SAM_1
TLS2_k127_168819_0	234267.Acid_1327	1.632e-113	383.0	COG0318@1|root,COG0318@2|Bacteria,3Y65U@57723|Acidobacteria	57723|Acidobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_168819_1	1232410.KI421412_gene337	9.939e-13	70.0	2C59E@1|root,2ZDAY@2|Bacteria	2|Bacteria	S	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_1703383_1	1340493.JNIF01000003_gene4109	3.741e-137	455.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	DUF1080,HEAT_2,T2SSE_N
TLS2_k127_1703383_2	234267.Acid_2380	1.854e-134	450.0	COG2133@1|root,COG3292@1|root,COG2133@2|Bacteria,COG3292@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,CHB_HEX_C_1,DUF1906,Glyco_hydro_18,Malectin,PA14,SLH,VCBS
TLS2_k127_1703383_4	136993.KB900626_gene3353	3.004e-41	157.0	COG3193@1|root,COG3193@2|Bacteria,1RGUD@1224|Proteobacteria,2UGI0@28211|Alphaproteobacteria,371DY@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
TLS2_k127_1703383_5	1254432.SCE1572_28415	9.987e-36	144.0	COG1309@1|root,COG1309@2|Bacteria,1N6TK@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_1703383_0	234267.Acid_1186	1.099e-265	839.0	COG1657@1|root,COG1657@2|Bacteria,3Y37N@57723|Acidobacteria	57723|Acidobacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
TLS2_k127_1703383_3	1120966.AUBU01000003_gene1531	1.529e-45	168.0	COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,47NH0@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_1718267_4	1528106.JRJE01000028_gene361	3.406e-10	62.0	2EIKT@1|root,33CC3@2|Bacteria,1N2RM@1224|Proteobacteria,2UD5M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1718267_1	1089552.KI911559_gene2018	3.697e-132	427.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2JV4G@204441|Rhodospirillales	204441|Rhodospirillales	L	HTH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve_3
TLS2_k127_1718267_2	1096930.L284_09175	8.635e-23	98.0	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,2K5CA@204457|Sphingomonadales	204457|Sphingomonadales	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1718267_0	323097.Nham_3943	2.57e-190	598.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3JR1M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_1718267_3	1096930.L284_09165	8.889e-14	72.0	COG2963@1|root,COG2963@2|Bacteria,1PNRN@1224|Proteobacteria,2V1B2@28211|Alphaproteobacteria,2KBBG@204457|Sphingomonadales	204457|Sphingomonadales	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1718267_5	335543.Sfum_4048	0.0002688	44.0	COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,42NP7@68525|delta/epsilon subdivisions,2WKJU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM OsmC family protein	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,OsmC
TLS2_k127_1719003_2	211165.AJLN01000141_gene2398	3.075e-33	132.0	COG1145@1|root,32UJ7@2|Bacteria,1G9Q2@1117|Cyanobacteria	1117|Cyanobacteria	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1719003_0	234267.Acid_7514	0.0	1513.0	COG3696@1|root,COG3696@2|Bacteria,3Y3AQ@57723|Acidobacteria	57723|Acidobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787,ko:K15726	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.2,2.A.6.1.4	-	-	ACR_tran
TLS2_k127_1719003_1	234267.Acid_7513	1.431e-101	340.0	COG0845@1|root,COG0845@2|Bacteria,3Y49U@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	HlyD_D23,YtkA
TLS2_k127_1721172_0	56780.SYN_00304	6.064e-52	201.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,43BJ8@68525|delta/epsilon subdivisions,2X708@28221|Deltaproteobacteria,2MSKI@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05366,ko:K21464	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS2_k127_172681_0	472759.Nhal_3041	5.343e-112	372.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1X12V@135613|Chromatiales	135613|Chromatiales	C	Cytochrome C oxidase subunit II, periplasmic domain	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,Cytochrom_C
TLS2_k127_172681_2	1218352.B597_013720	5.176e-60	236.0	COG2885@1|root,COG2982@1|root,COG2885@2|Bacteria,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria,1Z07Q@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748,OmpA
TLS2_k127_172681_1	221288.JH992900_gene291	5.308e-92	310.0	COG1226@1|root,2ZCE6@2|Bacteria,1FZWR@1117|Cyanobacteria,1JHYA@1189|Stigonemataceae	1117|Cyanobacteria	P	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2
TLS2_k127_172681_3	1121013.P873_10615	3.898e-40	154.0	COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,1RQUD@1236|Gammaproteobacteria,1X7P8@135614|Xanthomonadales	135614|Xanthomonadales	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
TLS2_k127_1728708_4	1123508.JH636445_gene6525	2.968e-07	53.0	COG1657@1|root,COG1657@2|Bacteria,2J1QU@203682|Planctomycetes	203682|Planctomycetes	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1728708_2	1340493.JNIF01000003_gene1514	3.248e-30	128.0	COG3485@1|root,COG3485@2|Bacteria,3Y9A8@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_1728708_1	234267.Acid_1857	6.319e-74	251.0	COG0735@1|root,COG0735@2|Bacteria,3Y5IN@57723|Acidobacteria	57723|Acidobacteria	P	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_1728708_0	234267.Acid_1856	3.378e-162	528.0	COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y45M@57723|Acidobacteria	57723|Acidobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF_2,SpoIIE
TLS2_k127_1728708_3	1382359.JIAL01000001_gene1502	1.798e-21	100.0	COG0828@1|root,COG0828@2|Bacteria,3Y5J9@57723|Acidobacteria,2JJWG@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
TLS2_k127_1731143_2	1123252.ATZF01000027_gene1612	3.735e-06	52.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
TLS2_k127_1731143_0	190650.CC_0139	1.103e-186	613.0	COG4772@1|root,COG4772@2|Bacteria,1MWDG@1224|Proteobacteria,2U4AH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG4772 Outer membrane receptor for Fe3 -dicitrate	-	-	-	ko:K16091	-	-	-	-	ko00000,ko02000	1.B.14.1.14	-	-	Plug,TonB_dep_Rec
TLS2_k127_1731143_1	234267.Acid_1297	3.552e-79	270.0	COG0324@1|root,COG0324@2|Bacteria,3Y3CE@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
TLS2_k127_1731825_2	234267.Acid_6709	8.382e-14	76.0	COG1404@1|root,COG1404@2|Bacteria,3Y5WB@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8
TLS2_k127_1731825_1	234267.Acid_0686	4.426e-20	103.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_0686|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1731825_0	1267535.KB906767_gene5141	4.53e-79	290.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria	57723|Acidobacteria	KU	WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_1742273_0	485918.Cpin_6532	5.31e-250	786.0	COG1770@1|root,COG1770@2|Bacteria,4NEQS@976|Bacteroidetes,1IQQY@117747|Sphingobacteriia	976|Bacteroidetes	E	Peptidase S9, prolyl oligopeptidase, catalytic domain	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_1742273_3	234267.Acid_7297	1.583e-112	375.0	COG0322@1|root,COG0322@2|Bacteria,3Y3HU@57723|Acidobacteria	57723|Acidobacteria	L	excinuclease ABC activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1742273_4	1267535.KB906767_gene5476	1.757e-85	297.0	COG0859@1|root,COG0859@2|Bacteria,3Y794@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
TLS2_k127_1742273_2	234267.Acid_7058	4.317e-130	422.0	COG0005@1|root,COG0005@2|Bacteria,3Y2MA@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_1742273_5	204669.Acid345_2365	1.732e-84	301.0	COG1703@1|root,COG1703@2|Bacteria,3Y40X@57723|Acidobacteria,2JHW8@204432|Acidobacteriia	204432|Acidobacteriia	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS2_k127_1742273_1	234267.Acid_1193	6.928e-209	655.0	COG0821@1|root,COG0821@2|Bacteria,3Y2GU@57723|Acidobacteria	57723|Acidobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TLS2_k127_1742273_6	1286632.P278_24970	6.955e-54	196.0	COG3622@1|root,COG3622@2|Bacteria,4NG74@976|Bacteroidetes,1HXKC@117743|Flavobacteriia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_1753531_3	1267535.KB906767_gene4207	6.456e-50	183.0	COG2134@1|root,COG2134@2|Bacteria,3Y7SW@57723|Acidobacteria	57723|Acidobacteria	I	cdp-diacylglycerol pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1753531_1	234267.Acid_1438	1.889e-124	414.0	COG1807@1|root,COG1807@2|Bacteria,3Y2K3@57723|Acidobacteria	57723|Acidobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_1753531_0	502025.Hoch_5119	4.482e-287	899.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,42Q77@68525|delta/epsilon subdivisions,2WK3N@28221|Deltaproteobacteria,2YU8G@29|Myxococcales	28221|Deltaproteobacteria	C	Sulfite reductase	-	-	1.7.7.1,1.8.1.2,1.8.7.1	ko:K00366,ko:K00381,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00858,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
TLS2_k127_1753531_4	502025.Hoch_5120	1.942e-23	107.0	2DUA0@1|root,33PJB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1753531_2	324602.Caur_3888	8.062e-73	256.0	COG2352@1|root,COG2352@2|Bacteria,2G62H@200795|Chloroflexi,374VU@32061|Chloroflexia	32061|Chloroflexia	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	-	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
TLS2_k127_1755738_2	439235.Dalk_1464	1.002e-30	124.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Z@68525|delta/epsilon subdivisions,2X6NB@28221|Deltaproteobacteria,2MPI8@213118|Desulfobacterales	1224|Proteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
TLS2_k127_1755738_1	1267535.KB906767_gene2978	1.12e-40	163.0	COG1414@1|root,COG1414@2|Bacteria,3Y57U@57723|Acidobacteria,2JMQF@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS2_k127_1755738_0	641524.ADICYQ_5476	5.97e-157	508.0	COG1053@1|root,COG1053@2|Bacteria,4NG56@976|Bacteroidetes,47YCZ@768503|Cytophagia	976|Bacteroidetes	C	HI0933-like protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_176300_0	401053.AciPR4_1573	2.469e-229	731.0	COG1629@1|root,COG4771@2|Bacteria,3Y368@57723|Acidobacteria,2JKVQ@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_1772149_2	1367847.JCM7686_1863	0.0002075	48.0	COG3240@1|root,COG3240@2|Bacteria,1Q0NF@1224|Proteobacteria,2V8VJ@28211|Alphaproteobacteria,2PYB2@265|Paracoccus	28211|Alphaproteobacteria	I	lipase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1772149_1	266779.Meso_2583	3.81e-36	146.0	COG2091@1|root,COG2091@2|Bacteria,1MZHC@1224|Proteobacteria,2UFA4@28211|Alphaproteobacteria,43M77@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	4'-phosphopantetheinyl transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_1772149_0	234267.Acid_2590	7.75e-59	210.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,3Y5S6@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
TLS2_k127_1779776_3	483218.BACPEC_03202	1.982e-19	98.0	COG2089@1|root,COG2089@2|Bacteria,1TS09@1239|Firmicutes,249DN@186801|Clostridia,26B08@186813|unclassified Clostridiales	186801|Clostridia	M	NeuB family	pseI	-	2.5.1.56,2.5.1.97	ko:K01654,ko:K15898	ko00520,ko01100,map00520,map01100	-	R01804,R04435,R09841	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
TLS2_k127_1779776_5	391625.PPSIR1_24714	2.355e-11	73.0	COG4122@1|root,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_20,Methyltransf_21,Methyltransf_24
TLS2_k127_1779776_0	867903.ThesuDRAFT_02043	2.518e-56	209.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,25F0C@186801|Clostridia,3WD52@538999|Clostridiales incertae sedis	186801|Clostridia	CH	PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.26,1.1.1.310,1.1.1.399,1.1.1.95	ko:K00015,ko:K00058,ko:K16843	ko00260,ko00270,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020	R00717,R01388,R01513,R05693	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
TLS2_k127_1779776_4	1232437.KL662017_gene509	1.527e-17	91.0	COG1083@1|root,COG1083@2|Bacteria,1QACI@1224|Proteobacteria,42QBP@68525|delta/epsilon subdivisions,2WNRH@28221|Deltaproteobacteria,2MKJ6@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Cytidylyltransferase	neuA	-	2.7.7.43	ko:K00983	ko00520,ko01100,map00520,map01100	-	R01117,R04215	RC00152	ko00000,ko00001,ko01000	-	-	-	CTP_transf_3
TLS2_k127_1779776_2	221360.RS9917_04695	3.745e-20	98.0	COG1216@1|root,COG1216@2|Bacteria,1G705@1117|Cyanobacteria,1H22C@1129|Synechococcus	1117|Cyanobacteria	S	Glycosyltransferase like family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2,RgpF
TLS2_k127_1779776_1	313624.NSP_50200	1.422e-30	123.0	COG1132@1|root,COG1132@2|Bacteria,1G13C@1117|Cyanobacteria,1HK78@1161|Nostocales	1117|Cyanobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_1780452_5	1209984.BN978_02294	3.861e-22	105.0	COG4221@1|root,COG4221@2|Bacteria,2I9Q8@201174|Actinobacteria,23446@1762|Mycobacteriaceae	201174|Actinobacteria	S	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_1780452_0	1267535.KB906767_gene4366	3.614e-297	949.0	COG1629@1|root,COG4771@2|Bacteria,3Y2WQ@57723|Acidobacteria,2JICR@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_1780452_3	234267.Acid_3489	4.176e-129	430.0	COG0745@1|root,COG0745@2|Bacteria,3Y2I8@57723|Acidobacteria	57723|Acidobacteria	KT	Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	Malectin
TLS2_k127_1780452_4	452637.Oter_0815	5.631e-50	196.0	COG0840@1|root,COG0840@2|Bacteria,46THW@74201|Verrucomicrobia,3K9B6@414999|Opitutae	414999|Opitutae	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,MCPsignal
TLS2_k127_1780452_2	278963.ATWD01000001_gene1276	9.182e-159	515.0	COG3263@1|root,COG3263@2|Bacteria,3Y9BQ@57723|Acidobacteria,2JP63@204432|Acidobacteriia	2|Bacteria	P	TrkA-C domain	cvrA	-	-	ko:K03316,ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36,2.A.36.6	-	-	Na_H_Exchanger,TrkA_C
TLS2_k127_1780452_1	1267535.KB906767_gene919	1.795e-177	558.0	COG1082@1|root,COG1082@2|Bacteria,3Y3U5@57723|Acidobacteria,2JI4Y@204432|Acidobacteriia	204432|Acidobacteriia	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS2_k127_1782971_4	1267535.KB906767_gene1512	3.018e-39	152.0	COG0500@1|root,COG0500@2|Bacteria,3Y5HU@57723|Acidobacteria	57723|Acidobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1782971_3	1267535.KB906767_gene1511	9.624e-49	181.0	COG1664@1|root,COG1664@2|Bacteria,3Y49V@57723|Acidobacteria	57723|Acidobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS2_k127_1782971_0	234267.Acid_7674	1.815e-161	526.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,3Y38S@57723|Acidobacteria	57723|Acidobacteria	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
TLS2_k127_1782971_5	1267535.KB906767_gene3359	3.087e-16	82.0	2EB4K@1|root,33CHY@2|Bacteria,3Y5VG@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1782971_1	1267535.KB906767_gene3360	1.042e-95	320.0	28JM9@1|root,2Z9DT@2|Bacteria,3Y2S6@57723|Acidobacteria,2JIQX@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1782971_2	234267.Acid_7670	4.94e-89	302.0	COG0115@1|root,COG0115@2|Bacteria,3Y6HY@57723|Acidobacteria	57723|Acidobacteria	EH	Amino-transferase class IV	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS2_k127_1808719_0	234267.Acid_0871	3e-91	323.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	234267.Acid_0871|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
TLS2_k127_1808719_2	1463861.JNXE01000033_gene2711	2.163e-22	104.0	2DNDB@1|root,32WX5@2|Bacteria,2IN36@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3455
TLS2_k127_1808719_1	1082933.MEA186_23031	3.826e-68	239.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.1.3.2,3.6.1.27	ko:K09474,ko:K19302	ko00550,ko00740,ko01100,ko02020,map00550,map00740,map01100,map02020	-	R00548,R05627	RC00002,RC00017	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
TLS2_k127_1811139_0	1267535.KB906767_gene1145	2.624e-161	514.0	COG0008@1|root,COG0008@2|Bacteria,3Y465@57723|Acidobacteria,2JHZW@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS2_k127_1811139_2	1267535.KB906767_gene4442	5.539e-82	279.0	COG0030@1|root,COG0030@2|Bacteria,3Y3RQ@57723|Acidobacteria,2JIX1@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TLS2_k127_1811139_4	1340493.JNIF01000003_gene2788	2.89e-18	94.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	rsrA	GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_1811139_3	1267535.KB906767_gene4444	1.467e-74	256.0	COG1595@1|root,COG1595@2|Bacteria,3Y4IW@57723|Acidobacteria,2JJ89@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_1811139_5	696747.NIES39_A04550	1.996e-08	57.0	COG2442@1|root,COG2442@2|Bacteria,1G9FC@1117|Cyanobacteria,1HDDA@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
TLS2_k127_1811139_6	292564.Cyagr_1982	2.301e-08	61.0	COG4113@1|root,COG4113@2|Bacteria,1GEC8@1117|Cyanobacteria,22TX1@167375|Cyanobium	1117|Cyanobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_1811139_1	1267535.KB906767_gene5147	1.155e-116	384.0	COG1793@1|root,COG1793@2|Bacteria,3Y3AP@57723|Acidobacteria,2JIGV@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA ligase	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
TLS2_k127_1815710_3	595593.JREV01000054_gene2389	1.14e-29	125.0	COG2160@1|root,COG2160@2|Bacteria,2GJNB@201174|Actinobacteria,1W8U5@1268|Micrococcaceae	201174|Actinobacteria	G	Catalyzes the conversion of L-arabinose to L-ribulose	araA	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Iso_C,Arabinose_Isome
TLS2_k127_1815710_2	1379698.RBG1_1C00001G1374	5.578e-37	144.0	COG4555@1|root,COG4555@2|Bacteria,2NS3N@2323|unclassified Bacteria	2|Bacteria	CP	AAA domain, putative AbiEii toxin, Type IV TA system	natA	-	3.6.3.7	ko:K01990,ko:K09697	ko02010,ko02020,map02010,map02020	M00253,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.115	-	iYO844.BSU02750	ABC_tran
TLS2_k127_1815710_0	204669.Acid345_4056	3.437e-143	465.0	COG4948@1|root,COG4948@2|Bacteria,3Y76H@57723|Acidobacteria,2JNKW@204432|Acidobacteriia	204432|Acidobacteriia	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_1815710_1	234267.Acid_3421	1.052e-47	173.0	COG0791@1|root,COG0791@2|Bacteria,3Y5IG@57723|Acidobacteria	57723|Acidobacteria	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,SPOR
TLS2_k127_1821273_1	1121904.ARBP01000029_gene2184	4.142e-111	370.0	COG4654@1|root,COG4654@2|Bacteria	2|Bacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PSCyt1,PSCyt2,PSD1
TLS2_k127_1821273_0	344747.PM8797T_17137	9.422e-188	597.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501,Sulfatase
TLS2_k127_182940_0	56107.Cylst_5603	2.835e-178	574.0	COG4644@1|root,COG4644@2|Bacteria,1G1K1@1117|Cyanobacteria,1HMWR@1161|Nostocales	1117|Cyanobacteria	L	Tn3 transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_Tn3,DUF4158
TLS2_k127_182940_3	582515.KR51_00018150	5.441e-05	46.0	COG0470@1|root,COG4916@1|root,COG0470@2|Bacteria,COG4916@2|Bacteria,1GEA1@1117|Cyanobacteria	1117|Cyanobacteria	L	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
TLS2_k127_182940_1	1267535.KB906767_gene3210	5.069e-44	175.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_182940_2	234267.Acid_1744	1.514e-07	56.0	COG1984@1|root,COG1984@2|Bacteria	2|Bacteria	E	allophanate hydrolase subunit 2	kipA	-	6.3.4.6	ko:K01941,ko:K06350	ko00220,ko00791,ko01100,map00220,map00791,map01100	-	R00774	RC00378	ko00000,ko00001,ko01000	-	-	-	CT_A_B,CT_C_D,SLH
TLS2_k127_1843559_1	1340493.JNIF01000003_gene3721	8.789e-117	382.0	COG0206@1|root,COG0206@2|Bacteria,3Y2WG@57723|Acidobacteria	57723|Acidobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS2_k127_1843559_0	1267535.KB906767_gene2558	1.12e-150	492.0	COG0849@1|root,COG0849@2|Bacteria,3Y432@57723|Acidobacteria,2JI1Q@204432|Acidobacteriia	204432|Acidobacteriia	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
TLS2_k127_1843559_2	234267.Acid_7309	2.45e-52	194.0	COG1589@1|root,COG1589@2|Bacteria,3Y3BQ@57723|Acidobacteria	57723|Acidobacteria	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
TLS2_k127_1845069_0	1267534.KB906757_gene1062	1.643e-59	227.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	1267534.KB906757_gene1062|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1845069_2	1267535.KB906767_gene4499	2.863e-42	166.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria,2JJS7@204432|Acidobacteriia	204432|Acidobacteriia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_1845069_1	1210884.HG799467_gene13370	1.305e-55	209.0	COG2837@1|root,COG2837@2|Bacteria,2J15G@203682|Planctomycetes	203682|Planctomycetes	P	iron assimilation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1845508_2	234267.Acid_1180	1.098e-65	238.0	COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	3.1.1.17	ko:K01053,ko:K13735	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05100,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220,map05100	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Calx-beta,DUF5122,NHL,SGL
TLS2_k127_1845508_1	234267.Acid_6764	2.331e-75	262.0	COG1427@1|root,COG1427@2|Bacteria,3Y3PU@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
TLS2_k127_1845508_0	234267.Acid_3614	4.388e-196	614.0	COG1060@1|root,COG1060@2|Bacteria,3Y2IA@57723|Acidobacteria	57723|Acidobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
TLS2_k127_1845508_3	1144275.COCOR_07488	1.497e-30	131.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2WIXQ@28221|Deltaproteobacteria,2YV8R@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the GPI family	pgi	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
TLS2_k127_185182_2	1242864.D187_008232	2.987e-122	398.0	2C57D@1|root,2Z7RS@2|Bacteria,1MX6G@1224|Proteobacteria,42Y78@68525|delta/epsilon subdivisions,2X3CW@28221|Deltaproteobacteria,2YUS0@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2891)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2891
TLS2_k127_185182_3	1288963.ADIS_1999	1.09e-92	316.0	COG1957@1|root,COG1957@2|Bacteria,4NJ4J@976|Bacteroidetes,47KD9@768503|Cytophagia	976|Bacteroidetes	F	Inosine-uridine preferring nucleoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	IU_nuc_hydro
TLS2_k127_185182_8	861299.J421_3334	8.608e-10	67.0	COG1228@1|root,COG1228@2|Bacteria,1ZTI7@142182|Gemmatimonadetes	861299.J421_3334|-	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_185182_7	518766.Rmar_2105	1.443e-28	120.0	COG1228@1|root,COG1228@2|Bacteria,4NF27@976|Bacteroidetes,1FIVC@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
TLS2_k127_185182_1	1267535.KB906767_gene1681	1.795e-143	466.0	COG0399@1|root,COG0399@2|Bacteria,3Y7K8@57723|Acidobacteria,2JK8Z@204432|Acidobacteriia	57723|Acidobacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_185182_6	1123508.JH636445_gene6747	8.08e-35	147.0	COG0801@1|root,COG1028@1|root,COG0801@2|Bacteria,COG1028@2|Bacteria,2IYIH@203682|Planctomycetes	203682|Planctomycetes	IQ	with different specificities (related to short-chain alcohol	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	HPPK,adh_short_C2
TLS2_k127_185182_0	234267.Acid_0957	7.22e-153	489.0	COG2255@1|root,COG2255@2|Bacteria,3Y2RP@57723|Acidobacteria	57723|Acidobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
TLS2_k127_185182_4	234267.Acid_0956	5.661e-69	242.0	COG0632@1|root,COG0632@2|Bacteria,3Y4KI@57723|Acidobacteria	57723|Acidobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
TLS2_k127_185182_5	1267535.KB906767_gene33	2.607e-66	234.0	COG1385@1|root,COG1385@2|Bacteria,3Y3XJ@57723|Acidobacteria,2JI6A@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
TLS2_k127_1858426_6	936455.KI421499_gene693	5.95e-92	306.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2TRMQ@28211|Alphaproteobacteria,3JRQ3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
TLS2_k127_1858426_1	1288963.ADIS_3072	1.907e-144	468.0	COG0412@1|root,COG0412@2|Bacteria,4NIXW@976|Bacteroidetes,47NY6@768503|Cytophagia	976|Bacteroidetes	Q	COG COG1073 Hydrolases of the alpha beta superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_7,Pec_lyase,Peptidase_S9
TLS2_k127_1858426_10	471854.Dfer_2215	1.538e-05	55.0	28NR7@1|root,2ZBQI@2|Bacteria,4NMCH@976|Bacteroidetes,47WBS@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1858426_3	1347342.BN863_9940	2.059e-126	417.0	COG3119@1|root,COG3119@2|Bacteria,4NF1X@976|Bacteroidetes,1HYYH@117743|Flavobacteriia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_1858426_4	1340493.JNIF01000003_gene2305	1.951e-121	396.0	COG2022@1|root,COG2022@2|Bacteria,3Y2YY@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
TLS2_k127_1858426_0	1340493.JNIF01000003_gene3465	3.422e-210	662.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_1858426_8	234267.Acid_7418	9.376e-28	116.0	COG3682@1|root,COG3682@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
TLS2_k127_1858426_2	1340493.JNIF01000003_gene1468	7.649e-136	443.0	COG3481@1|root,COG3481@2|Bacteria,3Y38F@57723|Acidobacteria	57723|Acidobacteria	S	nucleic acid binding	-	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
TLS2_k127_1858426_5	1340493.JNIF01000003_gene1469	2.511e-113	377.0	COG0760@1|root,COG0760@2|Bacteria,3Y3V9@57723|Acidobacteria	57723|Acidobacteria	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
TLS2_k127_1858426_7	1267535.KB906767_gene3251	1.771e-49	180.0	COG2271@1|root,COG2271@2|Bacteria,3Y2KA@57723|Acidobacteria,2JI0V@204432|Acidobacteriia	204432|Acidobacteriia	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
TLS2_k127_1866979_0	1183438.GKIL_3395	4.033e-158	529.0	COG0515@1|root,COG0515@2|Bacteria,1G3GV@1117|Cyanobacteria	1183438.GKIL_3395|-	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
TLS2_k127_1866979_1	234267.Acid_1085	1.425e-118	391.0	COG0123@1|root,COG0123@2|Bacteria,3Y46F@57723|Acidobacteria	57723|Acidobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TLS2_k127_1866979_2	234267.Acid_0042	8.08e-17	94.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1882977_3	290633.GOX0768	2.997e-14	81.0	COG1396@1|root,COG1396@2|Bacteria,1RDBW@1224|Proteobacteria,2U7CY@28211|Alphaproteobacteria,2JSZQ@204441|Rhodospirillales	204441|Rhodospirillales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS2_k127_1882977_1	1380391.JIAS01000013_gene3620	1.414e-64	235.0	COG3482@1|root,COG3482@2|Bacteria,1QG2J@1224|Proteobacteria,2TUJJ@28211|Alphaproteobacteria,2JSII@204441|Rhodospirillales	28211|Alphaproteobacteria	S	TfuA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TfuA
TLS2_k127_1882977_0	1246459.KB898353_gene425	1.082e-92	319.0	COG1944@1|root,COG1944@2|Bacteria,1N5NV@1224|Proteobacteria,2U1QX@28211|Alphaproteobacteria,4B7TS@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
TLS2_k127_1882977_2	1131813.AQVT01000001_gene1978	1.118e-33	135.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,1JTRP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Integrase core domain	MA20_10900	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_1882977_4	338969.Rfer_1357	0.0001739	50.0	2BFHP@1|root,329BG@2|Bacteria,1PWI4@1224|Proteobacteria,2WC2M@28216|Betaproteobacteria,4AIS9@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1884983_2	1340493.JNIF01000003_gene3568	2.922e-23	100.0	COG3618@1|root,COG3618@2|Bacteria	2|Bacteria	H	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_1884983_1	234267.Acid_0727	3.968e-66	231.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	yihX	GO:0003674,GO:0003824,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042578,GO:0042726,GO:0042727,GO:0043726,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.3.10,3.1.3.104,3.8.1.2	ko:K01560,ko:K07025,ko:K20866,ko:K21063	ko00010,ko00361,ko00625,ko00740,ko01100,ko01110,ko01120,map00010,map00361,map00625,map00740,map01100,map01110,map01120	M00125	R00947,R05287,R07280	RC00017,RC00078,RC00697	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2,Hydrolase
TLS2_k127_1884983_0	234267.Acid_5232	1.736e-170	541.0	COG1972@1|root,COG1972@2|Bacteria,3Y2KI@57723|Acidobacteria	57723|Acidobacteria	F	PFAM Na dependent nucleoside transporter	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
TLS2_k127_1890064_2	653733.Selin_0400	1.431e-68	238.0	COG2251@1|root,COG2251@2|Bacteria	2|Bacteria	-	-	nusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	DUF2779,HHH_5,KH_5,NusA_N,S1
TLS2_k127_1890064_1	215803.DB30_1351	3.41e-77	269.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_1890064_3	765911.Thivi_1538	2.077e-25	111.0	2EIG1@1|root,33C7D@2|Bacteria,1NNA9@1224|Proteobacteria,1SH4C@1236|Gammaproteobacteria,1X1KH@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1890064_4	472759.Nhal_0078	4.961e-21	98.0	COG1396@1|root,COG1396@2|Bacteria,1NFXC@1224|Proteobacteria,1SIYM@1236|Gammaproteobacteria,1WZUR@135613|Chromatiales	135613|Chromatiales	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS2_k127_1890064_0	1269813.ATUL01000016_gene19	3.266e-109	362.0	COG0210@1|root,COG0210@2|Bacteria,1MWW6@1224|Proteobacteria,1RYRU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,NERD,UvrD_C,UvrD_C_2
TLS2_k127_1893647_1	234267.Acid_4794	3.559e-26	108.0	COG0626@1|root,COG0626@2|Bacteria	2|Bacteria	E	cystathionine gamma-synthase activity	mdeA	-	2.5.1.48,4.4.1.11,4.4.1.8	ko:K01739,ko:K01760,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS2_k127_1893647_3	234267.Acid_0707	0.0004311	48.0	2E6Q0@1|root,331A9@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4926)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4926
TLS2_k127_1893647_0	234267.Acid_4962	1.107e-76	267.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_1893647_2	1267535.KB906767_gene5093	4.595e-20	100.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	DUF3376,Patatin
TLS2_k127_1894993_7	234267.Acid_5991	1.722e-99	332.0	COG0842@1|root,COG0842@2|Bacteria,3Y4H7@57723|Acidobacteria	57723|Acidobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_1894993_5	1340493.JNIF01000003_gene2588	6.501e-117	380.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_1894993_8	1340493.JNIF01000003_gene2589	3.547e-95	325.0	COG1131@1|root,COG1131@2|Bacteria,3Y725@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1894993_4	234267.Acid_5988	3.118e-119	396.0	COG1566@1|root,COG1566@2|Bacteria,3Y53G@57723|Acidobacteria	57723|Acidobacteria	V	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
TLS2_k127_1894993_3	234267.Acid_5987	3.389e-131	437.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS2_k127_1894993_2	234267.Acid_7913	4.991e-195	627.0	COG2203@1|root,COG3604@1|root,COG2203@2|Bacteria,COG3604@2|Bacteria,3Y9A3@57723|Acidobacteria	57723|Acidobacteria	KT	Sigma-54 interaction domain	-	-	-	ko:K15836	-	-	-	-	ko00000,ko03000	-	-	-	GAF_2,GAF_3,HTH_8,Sigma54_activat
TLS2_k127_1894993_0	1340493.JNIF01000004_gene873	8.457e-245	780.0	COG1629@1|root,COG4771@2|Bacteria,3Y36N@57723|Acidobacteria	57723|Acidobacteria	P	PFAM TonB-dependent Receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_1894993_9	234267.Acid_1444	9.914e-52	186.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	CP_0464	-	1.8.1.9	ko:K00384,ko:K01999,ko:K07001,ko:K10914	ko00450,ko02010,ko02020,ko02024,ko02025,ko02026,ko05111,map00450,map02010,map02020,map02024,map02025,map02026,map05111	M00237	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	3.A.1.4	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_1894993_1	234267.Acid_1443	4.569e-237	764.0	COG1413@1|root,COG3202@1|root,COG1413@2|Bacteria,COG3202@2|Bacteria	2|Bacteria	C	ATP:ADP antiporter activity	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	HEAT_2,NB-ARC,TLC,cNMP_binding
TLS2_k127_1894993_6	1340493.JNIF01000003_gene2259	7.353e-103	339.0	COG2230@1|root,COG2230@2|Bacteria,3Y9AA@57723|Acidobacteria	57723|Acidobacteria	M	DREV methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_1895905_3	1123242.JH636434_gene3868	4.621e-33	135.0	COG1520@1|root,COG1520@2|Bacteria,2IYRB@203682|Planctomycetes	1123242.JH636434_gene3868|-	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1895905_0	1267535.KB906767_gene5034	2.206e-119	416.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_1895905_2	1267535.KB906767_gene5033	4.047e-40	151.0	COG1695@1|root,COG1695@2|Bacteria,3Y5ZR@57723|Acidobacteria,2JK6A@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_1895905_5	240016.ABIZ01000001_gene4025	4.77e-07	56.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	vapC	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
TLS2_k127_1895905_4	1298867.AUES01000033_gene2088	2.167e-10	72.0	2DR6B@1|root,33ACQ@2|Bacteria,1NI4T@1224|Proteobacteria,2UKEW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1895905_1	1267535.KB906767_gene3342	2.799e-117	384.0	COG2234@1|root,COG2234@2|Bacteria,3Y3S9@57723|Acidobacteria,2JIF0@204432|Acidobacteriia	204432|Acidobacteriia	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
TLS2_k127_1905859_0	234267.Acid_2569	1.335e-110	361.0	COG0336@1|root,COG0336@2|Bacteria,3Y3CS@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
TLS2_k127_1905859_2	1267535.KB906767_gene3059	1.522e-49	179.0	COG0335@1|root,COG0335@2|Bacteria,3Y4P6@57723|Acidobacteria,2JJ9V@204432|Acidobacteriia	204432|Acidobacteriia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
TLS2_k127_1905859_1	234267.Acid_2565	3.221e-77	267.0	COG0164@1|root,COG0164@2|Bacteria,3Y49K@57723|Acidobacteria	57723|Acidobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
TLS2_k127_1905859_3	1340493.JNIF01000003_gene3708	3.074e-21	100.0	2DTVW@1|root,33MW2@2|Bacteria,3Y606@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_190642_5	234267.Acid_6120	9.53e-15	79.0	2ANB8@1|root,31D9I@2|Bacteria,3Y8WC@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_190642_3	1267535.KB906767_gene1212	1.837e-46	171.0	COG3436@1|root,COG3436@2|Bacteria,3Y875@57723|Acidobacteria	57723|Acidobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
TLS2_k127_190642_1	234267.Acid_2941	1.256e-137	442.0	2DB88@1|root,2Z7QT@2|Bacteria,3Y61J@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
TLS2_k127_190642_0	1267535.KB906767_gene1214	1.008e-192	614.0	COG2433@1|root,COG2433@2|Bacteria,3Y7F1@57723|Acidobacteria	57723|Acidobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
TLS2_k127_190642_4	1267535.KB906767_gene1218	3.716e-27	127.0	2DDV1@1|root,2ZJDR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_190642_2	234267.Acid_6125	1.953e-68	234.0	COG1961@1|root,COG1961@2|Bacteria,3Y5HT@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_7,Resolvase
TLS2_k127_1909054_0	1267535.KB906767_gene4432	7.066e-169	564.0	COG1629@1|root,COG1629@2|Bacteria,3Y620@57723|Acidobacteria,2JKZX@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_1909054_1	240016.ABIZ01000001_gene2352	6.953e-72	253.0	COG2072@1|root,COG2072@2|Bacteria,46U3S@74201|Verrucomicrobia	74201|Verrucomicrobia	P	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_1909054_2	1403819.BATR01000105_gene3647	6.889e-46	171.0	COG2072@1|root,COG2072@2|Bacteria,46U3S@74201|Verrucomicrobia	74201|Verrucomicrobia	P	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_1917221_2	420324.KI911977_gene3186	4.727e-55	201.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,1JWN3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
TLS2_k127_1917221_6	398767.Glov_0054	2.094e-10	72.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,42P9S@68525|delta/epsilon subdivisions,2WJI7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7
TLS2_k127_1917221_1	1267535.KB906767_gene5141	4.596e-122	418.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria	57723|Acidobacteria	KU	WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_1917221_3	1036674.A28LD_1047	2.808e-41	158.0	COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,1S62I@1236|Gammaproteobacteria,2QGXP@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
TLS2_k127_1917221_5	523791.Kkor_0401	2.81e-15	87.0	COG5660@1|root,COG5660@2|Bacteria,1NCWT@1224|Proteobacteria,1SDFE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_1917221_4	1122134.KB893650_gene14	5.22e-21	99.0	COG1595@1|root,COG1595@2|Bacteria,1N6YE@1224|Proteobacteria,1SFVH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_1917221_0	240016.ABIZ01000001_gene764	1.616e-129	432.0	COG3119@1|root,COG3119@2|Bacteria,46ZJS@74201|Verrucomicrobia,2IVBK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_1919981_2	324057.Pjdr2_4151	3.368e-94	319.0	COG3119@1|root,COG3119@2|Bacteria,1V6NF@1239|Firmicutes,4HKTS@91061|Bacilli,26V7Z@186822|Paenibacillaceae	91061|Bacilli	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_1919981_1	1449063.JMLS01000020_gene5261	2.826e-98	336.0	COG0823@1|root,COG0823@2|Bacteria,1UWV5@1239|Firmicutes,4IAY6@91061|Bacilli,273CS@186822|Paenibacillaceae	91061|Bacilli	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1919981_7	886293.Sinac_6095	5.203e-42	171.0	COG1073@1|root,COG1073@2|Bacteria,2IYEI@203682|Planctomycetes	203682|Planctomycetes	Q	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS2_k127_1919981_0	1267535.KB906767_gene3083	1.233e-196	653.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_1919981_5	1267535.KB906767_gene4919	3.587e-54	207.0	COG0745@1|root,COG0745@2|Bacteria,3Y67W@57723|Acidobacteria	57723|Acidobacteria	KT	RESPONSE REGULATOR receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1919981_4	234267.Acid_2737	1.831e-81	280.0	COG1414@1|root,COG1414@2|Bacteria,3Y57U@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS2_k127_1919981_3	452637.Oter_4263	2.574e-90	305.0	COG3717@1|root,COG3717@2|Bacteria,46TZ9@74201|Verrucomicrobia,3K8Q6@414999|Opitutae	414999|Opitutae	G	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate	-	-	5.3.1.17	ko:K01815	ko00040,map00040	-	R04383	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
TLS2_k127_1919981_6	234267.Acid_4418	1.713e-50	193.0	COG1629@1|root,COG4771@2|Bacteria,3Y3KA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_1928661_6	1123368.AUIS01000005_gene422	9.326e-105	350.0	COG0438@1|root,COG0438@2|Bacteria,1Q3IF@1224|Proteobacteria	1224|Proteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_1928661_1	1123368.AUIS01000005_gene423	1.187e-160	515.0	COG4641@1|root,COG4641@2|Bacteria,1MY6E@1224|Proteobacteria	1224|Proteobacteria	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2,Glyco_transf_4
TLS2_k127_1928661_0	1123368.AUIS01000005_gene424	1.447e-162	519.0	COG4641@1|root,COG4641@2|Bacteria,1MXSZ@1224|Proteobacteria	1224|Proteobacteria	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
TLS2_k127_1928661_2	1123368.AUIS01000005_gene446	2.808e-149	481.0	COG4641@1|root,COG4641@2|Bacteria	2|Bacteria	M	Protein conserved in bacteria	ykvP	-	-	-	-	-	-	-	-	-	-	-	DUF3880,Glyco_trans_1_2,Glyco_trans_1_4,Glycos_transf_1,Glycos_transf_2
TLS2_k127_1928661_5	1267535.KB906767_gene230	7.387e-114	393.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	AXE1,Peptidase_S9
TLS2_k127_1928661_7	1121381.JNIV01000125_gene365	4.962e-47	173.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_1928661_3	234267.Acid_2872	5.384e-141	469.0	COG1520@1|root,COG1520@2|Bacteria,3Y3UP@57723|Acidobacteria	57723|Acidobacteria	S	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans
TLS2_k127_1928661_4	234267.Acid_2871	1.311e-114	378.0	COG3119@1|root,COG3119@2|Bacteria,3Y679@57723|Acidobacteria	57723|Acidobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,Sulfatase_C
TLS2_k127_1937076_0	1340493.JNIF01000004_gene703	5.249e-136	437.0	COG0624@1|root,COG0624@2|Bacteria,3Y3TZ@57723|Acidobacteria	57723|Acidobacteria	E	peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_1937076_1	946077.W5A_07110	7.342e-66	234.0	COG1073@1|root,COG1073@2|Bacteria,4NG6A@976|Bacteroidetes,1I062@117743|Flavobacteriia	976|Bacteroidetes	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	AXE1,BAAT_C,Hydrolase_4
TLS2_k127_1938287_0	234267.Acid_2420	2.849e-281	881.0	COG1529@1|root,COG1529@2|Bacteria,3Y2ME@57723|Acidobacteria	57723|Acidobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_1938287_3	880073.Calab_1106	7.362e-53	196.0	COG2080@1|root,COG2080@2|Bacteria,2NPPX@2323|unclassified Bacteria	2|Bacteria	C	PFAM 2Fe-2S -binding	-	-	1.2.5.3,1.3.99.16	ko:K03518,ko:K07302,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2,TAT_signal
TLS2_k127_1938287_2	765911.Thivi_3415	3.328e-110	373.0	COG2271@1|root,COG2271@2|Bacteria,1MUEK@1224|Proteobacteria,1RMB4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Major facilitator superfamily	-	-	-	ko:K13021	-	-	-	-	ko00000,ko02000	2.A.1.14.3	-	-	MFS_1
TLS2_k127_1938287_5	1267535.KB906767_gene4811	9.926e-31	126.0	COG0745@1|root,COG0745@2|Bacteria,3Y8QP@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_1938287_1	234267.Acid_3254	2.793e-141	456.0	COG4783@1|root,COG4783@2|Bacteria,3Y3GF@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase M48 Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS2_k127_1938287_4	1267535.KB906767_gene5039	3.148e-47	172.0	COG0520@1|root,COG0520@2|Bacteria,3Y632@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_1942072_0	234267.Acid_0041	5.723e-174	567.0	COG4122@1|root,COG4122@2|Bacteria,3Y33U@57723|Acidobacteria	57723|Acidobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1942072_3	1454004.AW11_03199	3.018e-39	152.0	COG5156@1|root,COG5156@2|Bacteria,1N53Q@1224|Proteobacteria,2W66Z@28216|Betaproteobacteria	28216|Betaproteobacteria	DO	anaphase-promoting complex-dependent catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1942072_2	234267.Acid_7626	2.727e-62	224.0	COG3316@1|root,COG3316@2|Bacteria,3Y888@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
TLS2_k127_1942072_1	639030.JHVA01000001_gene1797	6.097e-94	333.0	COG1629@1|root,COG1629@2|Bacteria,3Y39E@57723|Acidobacteria,2JIU9@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_1942329_3	1123508.JH636439_gene1211	3.723e-05	46.0	COG1541@1|root,COG1541@2|Bacteria,2IWUR@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1942329_0	240016.ABIZ01000001_gene1451	2.451e-152	496.0	COG1012@1|root,COG1012@2|Bacteria,46UJM@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_1942329_1	314230.DSM3645_13770	1.783e-104	353.0	COG0438@1|root,COG0438@2|Bacteria,2IXZX@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_1942329_2	483219.LILAB_27660	2.891e-68	232.0	COG0110@1|root,COG0110@2|Bacteria,1RA2T@1224|Proteobacteria,42Z2R@68525|delta/epsilon subdivisions,2WUGF@28221|Deltaproteobacteria,2Z37Y@29|Myxococcales	28221|Deltaproteobacteria	S	Maltose acetyltransferase	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Mac
TLS2_k127_195874_0	234267.Acid_6490	2.332e-42	166.0	COG1386@1|root,COG1386@2|Bacteria,3Y3E0@57723|Acidobacteria	57723|Acidobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
TLS2_k127_1962825_3	1267535.KB906767_gene1059	8.329e-48	176.0	COG0644@1|root,COG0644@2|Bacteria,3Y5HW@57723|Acidobacteria,2JK2B@204432|Acidobacteriia	204432|Acidobacteriia	C	Glucose inhibited division protein A	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1962825_4	1433126.BN938_1424	6.104e-27	121.0	COG2520@1|root,COG2520@2|Bacteria	2|Bacteria	J	tRNA (guanine(37)-N(1))-methyltransferase activity	XK27_03530	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21,rRNA_methylase
TLS2_k127_1962825_2	1267535.KB906767_gene1058	3.289e-68	241.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
TLS2_k127_1962825_0	1340493.JNIF01000004_gene501	7.428e-100	328.0	COG1435@1|root,COG1435@2|Bacteria,3Y4XG@57723|Acidobacteria	57723|Acidobacteria	F	PFAM Thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
TLS2_k127_1962825_1	1340493.JNIF01000004_gene502	9.735e-85	289.0	COG1322@1|root,COG1322@2|Bacteria,3Y3JC@57723|Acidobacteria	57723|Acidobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1964293_3	1267535.KB906767_gene2306	1.033e-169	559.0	COG1629@1|root,COG1629@2|Bacteria,3Y9AK@57723|Acidobacteria	57723|Acidobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_1964293_5	1267535.KB906767_gene5365	2.511e-30	134.0	COG0457@1|root,COG0457@2|Bacteria	1267535.KB906767_gene5365|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1964293_6	639030.JHVA01000001_gene101	8.403e-23	108.0	COG0457@1|root,COG0457@2|Bacteria,3Y4E6@57723|Acidobacteria,2JKG2@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2
TLS2_k127_1964293_4	1144275.COCOR_01492	2.019e-58	233.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,1R5MU@1224|Proteobacteria,42UIQ@68525|delta/epsilon subdivisions,2WQAN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1964293_7	1123399.AQVE01000028_gene171	4.597e-22	113.0	COG1864@1|root,COG3291@1|root,COG3391@1|root,COG1864@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,1R5MU@1224|Proteobacteria,1RZ6G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD,REJ
TLS2_k127_1964293_8	234267.Acid_0388	6.054e-09	61.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
TLS2_k127_1964293_10	234267.Acid_0388	6.612e-05	46.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
TLS2_k127_1964293_1	1340493.JNIF01000003_gene3843	7.045e-226	707.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_1964293_0	1340493.JNIF01000003_gene3842	0.0	1141.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PSCyt1,PSCyt2,PSD1
TLS2_k127_1964293_9	1267535.KB906767_gene2026	4.617e-06	50.0	COG1225@1|root,COG1225@2|Bacteria,3Y9DJ@57723|Acidobacteria	57723|Acidobacteria	O	Glutathione peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_1964293_2	1340493.JNIF01000003_gene4387	1.733e-180	570.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_1966073_3	1380394.JADL01000017_gene539	3.082e-71	251.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TSCR@28211|Alphaproteobacteria,2JPN8@204441|Rhodospirillales	204441|Rhodospirillales	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS2_k127_1966073_5	1254432.SCE1572_31605	8.871e-16	89.0	COG3861@1|root,COG3861@2|Bacteria,1NHME@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF2382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382
TLS2_k127_1966073_0	234267.Acid_3483	1.637e-317	1002.0	COG0457@1|root,COG0457@2|Bacteria,3Y2IK@57723|Acidobacteria	57723|Acidobacteria	S	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8,UnbV_ASPIC,VCBS
TLS2_k127_1966073_2	1340493.JNIF01000003_gene3642	4.298e-107	356.0	COG0489@1|root,COG0489@2|Bacteria,3Y66Z@57723|Acidobacteria	57723|Acidobacteria	D	AAA domain	-	-	2.7.10.1	ko:K08252	-	-	-	-	ko00000,ko01000	-	-	-	-
TLS2_k127_1966073_1	1340493.JNIF01000003_gene3643	4.422e-145	481.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	GNVR,Wzz
TLS2_k127_1966073_4	1340493.JNIF01000003_gene3644	1.746e-52	194.0	COG1596@1|root,COG1596@2|Bacteria,3Y51C@57723|Acidobacteria	57723|Acidobacteria	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
TLS2_k127_1968304_0	1267535.KB906767_gene5080	4.341e-117	388.0	COG1503@1|root,COG1503@2|Bacteria,3Y6P2@57723|Acidobacteria	57723|Acidobacteria	J	eRF1 domain 3	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach,eRF1_3
TLS2_k127_1978288_1	251221.35214822	4.986e-72	261.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,VCBS
TLS2_k127_1978288_0	1123368.AUIS01000011_gene1139	3.609e-149	507.0	COG1404@1|root,COG1404@2|Bacteria,1R90Q@1224|Proteobacteria,1S01H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
TLS2_k127_1978939_5	1232410.KI421424_gene1783	5.555e-100	332.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,43TBR@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
TLS2_k127_1978939_7	1340493.JNIF01000003_gene1649	5.732e-60	213.0	COG0852@1|root,COG0852@2|Bacteria,3Y4IQ@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TLS2_k127_1978939_8	1340493.JNIF01000003_gene1650	3.179e-53	192.0	COG0838@1|root,COG0838@2|Bacteria,3Y5CV@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TLS2_k127_1978939_14	404589.Anae109_1345	1.811e-14	75.0	COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,42WUA@68525|delta/epsilon subdivisions	1224|Proteobacteria	H	thiamine biosynthesis protein ThiS	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS2_k127_1978939_2	1185876.BN8_01972	1.109e-186	590.0	COG4948@1|root,COG4948@2|Bacteria,4NGZF@976|Bacteroidetes,47NF7@768503|Cytophagia	976|Bacteroidetes	M	mandelate racemase muconate lactonizing	-	-	4.2.1.68	ko:K18334	ko00051,ko01120,map00051,map01120	-	R03688	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_1978939_4	234267.Acid_4272	2.106e-167	557.0	COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_1978939_3	1123270.ATUR01000002_gene2330	2.434e-178	579.0	COG1649@1|root,COG1649@2|Bacteria,1NP4V@1224|Proteobacteria,2UDGK@28211|Alphaproteobacteria,2K1N8@204457|Sphingomonadales	204457|Sphingomonadales	S	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6
TLS2_k127_1978939_11	246197.MXAN_5255	1.174e-21	100.0	COG2350@1|root,COG2350@2|Bacteria	2|Bacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_1978939_13	1340493.JNIF01000004_gene260	4.889e-21	98.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	MA20_44825	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_1978939_12	234267.Acid_4213	3.302e-21	93.0	2DG6A@1|root,2ZUQ0@2|Bacteria,3Y8Y2@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1978939_10	234267.Acid_7445	1.584e-35	145.0	COG0589@1|root,COG0589@2|Bacteria,3Y5Y7@57723|Acidobacteria	57723|Acidobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_1978939_0	234267.Acid_7185	3.892e-230	733.0	COG3386@1|root,COG3386@2|Bacteria,3Y2G7@57723|Acidobacteria	57723|Acidobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1978939_1	234267.Acid_7184	1.816e-220	701.0	COG1044@1|root,COG1044@2|Bacteria,3Y2ZS@57723|Acidobacteria	57723|Acidobacteria	M	SpoIVB peptidase S55	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S55
TLS2_k127_1978939_15	1340493.JNIF01000003_gene2598	1.718e-12	77.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_1978939_6	1123242.JH636437_gene6095	3.763e-68	236.0	COG1073@1|root,COG1073@2|Bacteria,2IYEI@203682|Planctomycetes	203682|Planctomycetes	Q	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS2_k127_1999035_2	234267.Acid_3692	2.322e-71	254.0	COG2304@1|root,COG2304@2|Bacteria,3Y44P@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_1999035_1	234267.Acid_3449	7.51e-95	334.0	COG4775@1|root,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TLS2_k127_1999035_3	642492.Clole_2708	5.23e-42	170.0	COG2382@1|root,COG2382@2|Bacteria,1VHGN@1239|Firmicutes,25BTU@186801|Clostridia	186801|Clostridia	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CBM_2,Esterase,Glyco_hydro_10,RicinB_lectin_2
TLS2_k127_1999035_0	471854.Dfer_0331	4.762e-157	504.0	COG2382@1|root,COG2382@2|Bacteria,4NFVV@976|Bacteroidetes,47M66@768503|Cytophagia	976|Bacteroidetes	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	CBM_48,Esterase
TLS2_k127_1999035_4	886293.Sinac_3870	1.791e-41	157.0	COG3119@1|root,COG3119@2|Bacteria,2IXH3@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_2003285_0	234267.Acid_6955	1.087e-305	953.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria	2|Bacteria	I	cobalamin binding	mutB	-	5.4.99.2	ko:K01847,ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
TLS2_k127_2003285_2	234267.Acid_6956	3.699e-164	531.0	COG1884@1|root,COG1884@2|Bacteria,3Y2PQ@57723|Acidobacteria	2|Bacteria	I	Methylmalonyl-CoA mutase	mutA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016999,GO:0017144,GO:0019541,GO:0019678,GO:0019752,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046459,GO:0071704,GO:0071944	2.7.7.7,5.4.99.2,5.4.99.63	ko:K01847,ko:K03763,ko:K14447	ko00230,ko00240,ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,ko03030,ko03430,ko03440,map00230,map00240,map00280,map00630,map00640,map00720,map01100,map01120,map01200,map03030,map03430,map03440	M00260,M00373,M00376,M00741	R00375,R00376,R00377,R00378,R00833,R09292	RC00395,RC02795,RC02835	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	MM_CoA_mutase
TLS2_k127_2003285_4	234267.Acid_6957	1.308e-78	264.0	COG0346@1|root,COG0346@2|Bacteria,3Y80M@57723|Acidobacteria	57723|Acidobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
TLS2_k127_2003285_5	234267.Acid_6958	8.012e-38	145.0	COG4770@1|root,COG4770@2|Bacteria,3Y8NX@57723|Acidobacteria	57723|Acidobacteria	I	Biotin-requiring enzyme	-	-	2.1.3.1	ko:K17490	ko00640,map00640	-	R00353	RC00040	ko00000,ko00001,ko01000	-	-	-	Biotin_lipoyl
TLS2_k127_2003285_1	234267.Acid_6960	3.865e-267	839.0	COG4799@1|root,COG4799@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	mmdA	-	2.1.3.1,2.1.3.15,6.4.1.3	ko:K01966,ko:K17489	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R00353,R01859	RC00040,RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0716	Carboxyl_trans
TLS2_k127_2003285_3	234267.Acid_6961	1.186e-100	331.0	COG5016@1|root,COG5016@2|Bacteria,3Y6G9@57723|Acidobacteria	57723|Acidobacteria	C	Conserved carboxylase domain	-	-	2.1.3.1	ko:K03416	ko00640,map00640	-	R00353,R00930	RC00040,RC00097	ko00000,ko00001,ko01000	-	-	-	HMGL-like,PYC_OADA
TLS2_k127_2005121_1	1340493.JNIF01000003_gene4144	2.178e-58	211.0	COG1629@1|root,COG4771@2|Bacteria,3Y3KA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_2005121_0	313628.LNTAR_22304	5.408e-86	300.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_2005391_1	156889.Mmc1_2782	9.957e-69	246.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,2U24Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
TLS2_k127_2005391_2	1038860.AXAP01000028_gene555	2.374e-23	104.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,2U24Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
TLS2_k127_2005391_0	1041147.AUFB01000032_gene5861	6.195e-83	288.0	COG4974@1|root,COG4974@2|Bacteria,1R72R@1224|Proteobacteria,2U27G@28211|Alphaproteobacteria,4BM02@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_2005391_3	237609.PSAKL28_30600	1.62e-13	73.0	COG4974@1|root,COG4974@2|Bacteria,1QVIY@1224|Proteobacteria,1T3E7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_2006157_0	1479238.JQMZ01000001_gene2431	6.102e-42	173.0	COG0793@1|root,COG0793@2|Bacteria,1N5BU@1224|Proteobacteria	1224|Proteobacteria	M	Belongs to the peptidase S41A family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2006157_1	1479237.JMLY01000001_gene2242	1.609e-24	120.0	2BVHX@1|root,32QW9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2008675_3	1267535.KB906767_gene4800	3.684e-28	117.0	COG2823@1|root,COG2823@2|Bacteria,3Y8DF@57723|Acidobacteria	57723|Acidobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS2_k127_2008675_1	1293047.CBMA010000026_gene1644	1.996e-35	141.0	COG0784@1|root,arCOG02589@2157|Archaea,2XVUK@28890|Euryarchaeota,23V7T@183963|Halobacteria	183963|Halobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_2008675_0	234267.Acid_3241	4.365e-118	385.0	COG0020@1|root,COG0020@2|Bacteria,3Y485@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS2_k127_2008675_2	234267.Acid_3240	2.089e-33	138.0	COG4589@1|root,COG4589@2|Bacteria,3Y59Y@57723|Acidobacteria	57723|Acidobacteria	S	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TLS2_k127_2017021_0	1123073.KB899241_gene3464	3.159e-70	260.0	COG0793@1|root,COG0793@2|Bacteria,1PW54@1224|Proteobacteria,1SXHB@1236|Gammaproteobacteria,1X8XJ@135614|Xanthomonadales	135614|Xanthomonadales	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2017021_3	472759.Nhal_3409	1.411e-08	56.0	COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,1S9E4@1236|Gammaproteobacteria,1WZ4X@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
TLS2_k127_2017021_1	317619.ANKN01000109_gene1353	6.255e-15	80.0	COG1451@1|root,COG1451@2|Bacteria,1G1B3@1117|Cyanobacteria,1MP48@1212|Prochloraceae	1117|Cyanobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
TLS2_k127_2017021_2	314278.NB231_09643	3.682e-13	75.0	2DBQY@1|root,2ZAHD@2|Bacteria,1QYTK@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
TLS2_k127_2017021_4	1118235.CAJH01000078_gene3718	0.0003888	47.0	2DBQY@1|root,2ZAHD@2|Bacteria,1QYTK@1224|Proteobacteria,1T3V2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Transposase zinc-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
TLS2_k127_2022043_6	1340493.JNIF01000004_gene730	2.266e-23	101.0	COG0006@1|root,COG0006@2|Bacteria,3Y36W@57723|Acidobacteria	57723|Acidobacteria	E	peptidase M24B X-Pro dipeptidase aminopeptidase domain protein	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
TLS2_k127_2022043_1	234267.Acid_1521	1.171e-101	345.0	2EXCM@1|root,33QP8@2|Bacteria,3Y730@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2022043_0	234267.Acid_6345	5.793e-105	351.0	COG1533@1|root,COG1533@2|Bacteria,3Y2S5@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_2022043_5	234267.Acid_6359	5.066e-31	125.0	COG1324@1|root,COG1324@2|Bacteria,3Y5P7@57723|Acidobacteria	57723|Acidobacteria	P	CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
TLS2_k127_2022043_7	391587.KAOT1_02912	0.0007316	52.0	COG1807@1|root,COG4642@1|root,COG1807@2|Bacteria,COG4642@2|Bacteria,4PME4@976|Bacteroidetes	976|Bacteroidetes	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	MORN
TLS2_k127_2022043_2	1390370.O203_04190	8.284e-49	183.0	COG2227@1|root,COG2227@2|Bacteria,1N6SE@1224|Proteobacteria,1SCC1@1236|Gammaproteobacteria,1YEEZ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
TLS2_k127_2022043_3	935845.JADQ01000032_gene1332	3.169e-44	171.0	COG1216@1|root,COG1216@2|Bacteria,1TS11@1239|Firmicutes,4HDKY@91061|Bacilli,26U9S@186822|Paenibacillaceae	91061|Bacilli	S	Glycosyl transferase family 2	ycbB	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
TLS2_k127_2022043_4	1340493.JNIF01000003_gene2305	7.01e-39	146.0	COG2022@1|root,COG2022@2|Bacteria,3Y2YY@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
TLS2_k127_202252_1	234267.Acid_2994	5.89e-130	417.0	COG0627@1|root,COG0627@2|Bacteria,3Y63W@57723|Acidobacteria	57723|Acidobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
TLS2_k127_202252_0	1282361.ABAC402_18930	1.255e-293	914.0	COG1621@1|root,COG3507@1|root,COG1621@2|Bacteria,COG3507@2|Bacteria,1QS8P@1224|Proteobacteria,2U2I7@28211|Alphaproteobacteria,2KHQK@204458|Caulobacterales	204458|Caulobacterales	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
TLS2_k127_202252_2	234267.Acid_0821	1.049e-75	263.0	COG0611@1|root,COG0611@2|Bacteria,3Y30U@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_2024943_2	648885.KB316282_gene434	3.979e-26	117.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,1JTJM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,MASE4,PAS_3,PAS_4,Response_reg,dCache_1
TLS2_k127_2024943_1	935548.KI912159_gene973	3.227e-49	181.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,2TRTV@28211|Alphaproteobacteria,43H8V@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
TLS2_k127_2024943_0	639030.JHVA01000001_gene3427	5.816e-91	307.0	COG0467@1|root,COG0467@2|Bacteria,3Y2U8@57723|Acidobacteria,2JIQ8@204432|Acidobacteriia	204432|Acidobacteriia	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
TLS2_k127_2024943_5	1142394.PSMK_27660	0.00085	45.0	COG3871@1|root,COG3871@2|Bacteria,2IZQ9@203682|Planctomycetes	203682|Planctomycetes	S	general stress protein 26	-	-	-	-	-	-	-	-	-	-	-	-	Pyrid_ox_like
TLS2_k127_2024943_4	28583.AMAG_07471T0	3.456e-07	54.0	2AM79@1|root,2RZBA@2759|Eukaryota,38F21@33154|Opisthokonta,3P0WH@4751|Fungi	4751|Fungi	S	Bli-3 protein	-	-	-	-	-	-	-	-	-	-	-	-	Pyrid_ox_like
TLS2_k127_2024943_3	710696.Intca_3494	2.34e-12	69.0	COG1321@1|root,COG1321@2|Bacteria,2GN2R@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2030160_5	794903.OPIT5_22525	5.14e-30	135.0	COG0467@1|root,COG0467@2|Bacteria,46S8R@74201|Verrucomicrobia,3K9PE@414999|Opitutae	414999|Opitutae	T	Pfam:KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
TLS2_k127_2030160_0	234267.Acid_2458	1.219e-155	496.0	COG0113@1|root,COG0113@2|Bacteria,3Y2VK@57723|Acidobacteria	57723|Acidobacteria	H	PFAM delta-aminolevulinic acid dehydratase	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
TLS2_k127_2030160_3	234267.Acid_3429	8.086e-40	158.0	COG1652@1|root,COG1652@2|Bacteria,3Y84E@57723|Acidobacteria	57723|Acidobacteria	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
TLS2_k127_2030160_4	1502852.FG94_04316	2.698e-39	154.0	2BZPY@1|root,3347P@2|Bacteria,1NDQW@1224|Proteobacteria,2W3VX@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2030160_1	945713.IALB_2157	2.25e-155	511.0	COG1297@1|root,COG1297@2|Bacteria	2|Bacteria	S	iron-nicotianamine transmembrane transporter activity	oliA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085	-	-	-	-	-	-	-	-	-	-	OPT
TLS2_k127_2030160_2	1340493.JNIF01000004_gene78	2.915e-113	376.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS2_k127_20557_1	261292.Nit79A3_3543	8.145e-136	439.0	COG1352@1|root,COG2201@1|root,COG3352@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG3352@2|Bacteria,1NQTI@1224|Proteobacteria,2WGKT@28216|Betaproteobacteria,372IJ@32003|Nitrosomonadales	28216|Betaproteobacteria	NT	PFAM Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,PAS_10
TLS2_k127_20557_0	1479237.JMLY01000001_gene3324	2.726e-137	444.0	COG0778@1|root,COG0778@2|Bacteria,1NTK9@1224|Proteobacteria,1S1PQ@1236|Gammaproteobacteria,467T1@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_20557_2	1282876.BAOK01000001_gene3580	8.749e-61	221.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,4BR9M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	iorB	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
TLS2_k127_205742_2	378806.STAUR_3356	6.762e-17	93.0	COG3509@1|root,COG3509@2|Bacteria,1PI9N@1224|Proteobacteria,439C2@68525|delta/epsilon subdivisions,2X4K6@28221|Deltaproteobacteria,2YVGR@29|Myxococcales	28221|Deltaproteobacteria	Q	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
TLS2_k127_205742_0	1340493.JNIF01000003_gene2251	1.301e-156	503.0	COG2159@1|root,COG2159@2|Bacteria,3Y2HY@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_205742_1	234267.Acid_4046	4.985e-80	276.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_4046|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2064168_1	530564.Psta_2330	8.559e-12	74.0	COG1595@1|root,COG1595@2|Bacteria,2IZ91@203682|Planctomycetes	203682|Planctomycetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2064168_0	401053.AciPR4_1573	3.017e-108	361.0	COG1629@1|root,COG4771@2|Bacteria,3Y368@57723|Acidobacteria,2JKVQ@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_2066841_2	383372.Rcas_2398	4.036e-48	181.0	COG5441@1|root,COG5441@2|Bacteria,2G7QM@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterised protein family (UPF0261)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0261
TLS2_k127_2066841_3	485917.Phep_0811	1.125e-42	167.0	COG3828@1|root,COG3828@2|Bacteria,4NRZF@976|Bacteroidetes,1IVGZ@117747|Sphingobacteriia	976|Bacteroidetes	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
TLS2_k127_2066841_1	1172188.KB911823_gene522	9.315e-52	203.0	COG1167@1|root,COG1167@2|Bacteria,2GM6I@201174|Actinobacteria,4FG2E@85021|Intrasporangiaceae	201174|Actinobacteria	K	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
TLS2_k127_2066841_0	1340493.JNIF01000003_gene2052	7.917e-72	246.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
TLS2_k127_2067692_2	314264.ROS217_20202	4.589e-06	57.0	COG2334@1|root,COG2334@2|Bacteria,1NJ9A@1224|Proteobacteria,2UK76@28211|Alphaproteobacteria,46P9X@74030|Roseovarius	28211|Alphaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_2067692_0	306281.AJLK01000188_gene1251	3.393e-128	432.0	COG1132@1|root,COG1132@2|Bacteria,1G1JY@1117|Cyanobacteria,1JJ9N@1189|Stigonemataceae	1117|Cyanobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_2067692_1	401053.AciPR4_2699	8.38e-106	357.0	COG5029@1|root,COG5029@2|Bacteria	2|Bacteria	O	Prenyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
TLS2_k127_2068754_2	420324.KI912025_gene30	4.865e-60	216.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,1JZ49@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
TLS2_k127_2068754_0	1340493.JNIF01000004_gene603	7.988e-172	553.0	COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,3Y3AX@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_7
TLS2_k127_2068754_1	246197.MXAN_0271	8.384e-68	254.0	COG5492@1|root,COG5492@2|Bacteria,1QXT5@1224|Proteobacteria,43C5K@68525|delta/epsilon subdivisions,2X7FV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2068754_3	518766.Rmar_2560	1.133e-56	209.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,4NEIE@976|Bacteroidetes,1FIS3@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,OMP_b-brl_3,Plug,TonB_dep_Rec
TLS2_k127_2070781_1	574087.Acear_0206	9.013e-20	91.0	COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,24HZM@186801|Clostridia,3WAQ5@53433|Halanaerobiales	186801|Clostridia	E	TIGRFAM acetolactate synthase, small subunit	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
TLS2_k127_2070781_0	926569.ANT_03280	1.067e-176	559.0	COG0059@1|root,COG0059@2|Bacteria,2G5NP@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
TLS2_k127_2072096_2	314230.DSM3645_21427	1.275e-87	303.0	COG1387@1|root,COG2755@1|root,COG1387@2|Bacteria,COG2755@2|Bacteria,2IXFZ@203682|Planctomycetes	203682|Planctomycetes	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_2072096_0	234267.Acid_4421	2.765e-179	569.0	COG0126@1|root,COG0126@2|Bacteria,3Y2T7@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
TLS2_k127_2072326_2	1123366.TH3_20778	6.699e-21	97.0	COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,2TS9I@28211|Alphaproteobacteria,2JUB2@204441|Rhodospirillales	204441|Rhodospirillales	V	Subunit R is required for both nuclease and ATPase activities, but not for modification	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
TLS2_k127_2072326_3	1267535.KB906767_gene1333	2.637e-13	77.0	COG0745@1|root,COG0745@2|Bacteria,3Y8Y3@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_2072326_4	234267.Acid_2528	5.622e-05	48.0	COG4372@1|root,COG4372@2|Bacteria	2|Bacteria	Q	Transposase	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,DUF3084,LZ_Tnp_IS66,zf-IS66
TLS2_k127_2072326_0	1340493.JNIF01000003_gene2052	2.051e-35	137.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
TLS2_k127_2072326_1	1340493.JNIF01000004_gene314	1.061e-23	103.0	COG2433@1|root,COG2433@2|Bacteria,3Y5W3@57723|Acidobacteria	57723|Acidobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,LZ_Tnp_IS66,zf-IS66
TLS2_k127_2074498_1	234267.Acid_7363	1.793e-174	556.0	COG3359@1|root,COG3359@2|Bacteria,3Y6WT@57723|Acidobacteria	57723|Acidobacteria	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
TLS2_k127_2074498_0	1267535.KB906767_gene929	2.52e-288	897.0	COG0488@1|root,COG0488@2|Bacteria,3Y340@57723|Acidobacteria,2JI2P@204432|Acidobacteriia	204432|Acidobacteriia	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
TLS2_k127_2074498_2	234267.Acid_4539	7.081e-118	382.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,3Y6VT@57723|Acidobacteria	57723|Acidobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
TLS2_k127_207839_1	861299.J421_2129	3.559e-92	310.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_207839_0	196367.JNFG01000215_gene827	1.512e-110	370.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2VJFX@28216|Betaproteobacteria,1K04I@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Alcohol dehydrogenase zinc-binding domain protein	-	-	1.1.1.1,1.6.5.5	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
TLS2_k127_2080124_2	234267.Acid_3655	1.464e-170	553.0	COG0038@1|root,COG0457@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0457@2|Bacteria,COG0517@2|Bacteria,3Y2G4@57723|Acidobacteria	57723|Acidobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
TLS2_k127_2080124_14	1267533.KB906735_gene4555	0.0004386	52.0	COG0457@1|root,COG0457@2|Bacteria,3Y7BQ@57723|Acidobacteria,2JMD5@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
TLS2_k127_2080124_0	234267.Acid_5353	0.0	1381.0	COG0060@1|root,COG0060@2|Bacteria,3Y3JW@57723|Acidobacteria	57723|Acidobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
TLS2_k127_2080124_10	234267.Acid_5352	1.327e-39	153.0	COG0597@1|root,COG0597@2|Bacteria,3Y55H@57723|Acidobacteria	57723|Acidobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
TLS2_k127_2080124_6	1267535.KB906767_gene2618	4.284e-95	318.0	COG0682@1|root,COG0682@2|Bacteria,3Y4HT@57723|Acidobacteria,2JJTI@204432|Acidobacteriia	204432|Acidobacteriia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	-	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
TLS2_k127_2080124_4	234267.Acid_5138	1.085e-142	466.0	COG4198@1|root,COG4198@2|Bacteria,3Y2H9@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Uncharacterised conserved protein UCP033563	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
TLS2_k127_2080124_13	682795.AciX8_4021	2.621e-19	100.0	COG5616@1|root,COG5616@2|Bacteria,3Y9AR@57723|Acidobacteria,2JP78@204432|Acidobacteriia	204432|Acidobacteriia	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2080124_5	1267535.KB906767_gene1283	6.895e-102	337.0	COG1187@1|root,COG1187@2|Bacteria,3Y6Y9@57723|Acidobacteria,2JP1I@204432|Acidobacteriia	204432|Acidobacteriia	J	RNA pseudouridylate synthase	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_2080124_8	1340493.JNIF01000004_gene1099	1.203e-84	288.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
TLS2_k127_2080124_9	1340493.JNIF01000004_gene410	9.937e-76	262.0	COG1413@1|root,COG1413@2|Bacteria,3Y7N7@57723|Acidobacteria	57723|Acidobacteria	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_2080124_3	234267.Acid_6565	7.075e-152	487.0	COG3386@1|root,COG3386@2|Bacteria,3Y6WN@57723|Acidobacteria	57723|Acidobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2080124_7	234267.Acid_5860	1.411e-89	315.0	COG1807@1|root,COG1807@2|Bacteria,3Y7PC@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2080124_12	234267.Acid_6742	6.75e-38	149.0	2DYK5@1|root,34A5U@2|Bacteria,3Y8GF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl_2
TLS2_k127_2080124_1	1340493.JNIF01000004_gene448	1.203e-250	782.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3IB@57723|Acidobacteria	57723|Acidobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_2080206_1	234267.Acid_5438	3.824e-113	374.0	COG1462@1|root,COG1462@2|Bacteria,3Y3KF@57723|Acidobacteria	57723|Acidobacteria	M	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
TLS2_k127_2080206_0	234267.Acid_0222	6.028e-123	412.0	COG0515@1|root,COG0515@2|Bacteria,3Y6PF@57723|Acidobacteria	57723|Acidobacteria	KLT	SMART tyrosine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_2080206_2	234267.Acid_4985	2.931e-15	79.0	2BN2D@1|root,32GNW@2|Bacteria,3Y5X1@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2080206_3	234267.Acid_1341	8.59e-14	74.0	COG0454@1|root,COG0456@2|Bacteria,3Y5H6@57723|Acidobacteria	57723|Acidobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_2081431_0	234267.Acid_2616	6.911e-245	775.0	COG0366@1|root,COG0366@2|Bacteria,3Y71K@57723|Acidobacteria	57723|Acidobacteria	G	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
TLS2_k127_2087292_1	373994.Riv7116_6122	7.718e-43	164.0	COG2085@1|root,COG2085@2|Bacteria,1G8DX@1117|Cyanobacteria,1HPSF@1161|Nostocales	1117|Cyanobacteria	S	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
TLS2_k127_2087292_0	234267.Acid_1786	1.851e-162	522.0	COG1012@1|root,COG1012@2|Bacteria,3Y6J2@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79,1.2.99.10	ko:K00135,ko:K22445	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_2091418_1	234267.Acid_5869	1.213e-80	276.0	COG1629@1|root,COG4771@2|Bacteria,3Y368@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_2091418_2	667632.KB890194_gene3502	1.626e-69	254.0	COG0840@1|root,COG4251@1|root,COG0840@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VJGY@28216|Betaproteobacteria,1KGEK@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HAMP,HATPase_c,HisKA,PAS,PAS_9,TarH
TLS2_k127_2091418_3	34007.IT40_08265	1.097e-64	230.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2PUI7@265|Paracoccus	28211|Alphaproteobacteria	P	With GsiBCD is involved in glutathione import	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_2091418_4	991905.SL003B_2174	2.336e-63	230.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,4BPE4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032,ko:K13896	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	ABC_tran,oligo_HPY
TLS2_k127_2091418_0	234267.Acid_3458	3.425e-86	297.0	COG0601@1|root,COG0601@2|Bacteria,3Y437@57723|Acidobacteria	57723|Acidobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_2091418_5	1158338.JNLJ01000005_gene1754	9.995e-47	174.0	COG1173@1|root,COG1173@2|Bacteria,2G3I0@200783|Aquificae	200783|Aquificae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_2093929_3	1183438.GKIL_2770	7.268e-56	210.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1G1EB@1117|Cyanobacteria	1117|Cyanobacteria	KLT	serine threonine protein kinase	-	-	2.7.1.37,2.7.11.1	ko:K00870,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FHA,Pkinase,TPR_11,TPR_16,TPR_8
TLS2_k127_2093929_0	1123392.AQWL01000002_gene1980	3.069e-126	410.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2VH08@28216|Betaproteobacteria,1KSIB@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
TLS2_k127_2093929_2	234267.Acid_7537	3.16e-71	246.0	COG2717@1|root,COG2717@2|Bacteria,3Y58Y@57723|Acidobacteria	57723|Acidobacteria	C	Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
TLS2_k127_2093929_1	477974.Daud_0851	4.429e-104	362.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,264Z9@186807|Peptococcaceae	186801|Clostridia	G	Alpha-amylase domain	ams	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
TLS2_k127_2095109_2	204669.Acid345_4155	6.717e-68	253.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria,2JIZ4@204432|Acidobacteriia	204432|Acidobacteriia	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_2095109_1	1267535.KB906767_gene1348	1.974e-186	597.0	COG3534@1|root,COG3534@2|Bacteria,3Y48A@57723|Acidobacteria,2JKQ1@204432|Acidobacteriia	204432|Acidobacteriia	G	Alpha-L-arabinofuranosidase C-terminus	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
TLS2_k127_2095109_3	1192759.AKIB01000088_gene2205	3.529e-06	51.0	COG3534@1|root,COG3534@2|Bacteria,1PPWJ@1224|Proteobacteria,2TWSD@28211|Alphaproteobacteria,2K23Z@204457|Sphingomonadales	204457|Sphingomonadales	G	Alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
TLS2_k127_2095109_0	1340493.JNIF01000003_gene4144	3.899e-245	773.0	COG1629@1|root,COG4771@2|Bacteria,3Y3KA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_2095653_1	234267.Acid_4600	1.447e-81	282.0	COG1807@1|root,COG1807@2|Bacteria,3Y3BJ@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_2095653_0	234267.Acid_4601	5.483e-152	486.0	COG0524@1|root,COG0524@2|Bacteria,3Y3GE@57723|Acidobacteria	57723|Acidobacteria	G	PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS2_k127_2096270_1	1346791.M529_04545	4.647e-122	398.0	COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,2TTHW@28211|Alphaproteobacteria,2K02B@204457|Sphingomonadales	204457|Sphingomonadales	G	Major Facilitator Superfamily	-	-	-	ko:K03535	-	-	-	-	ko00000,ko02000	2.A.1.14.1	-	-	MFS_1
TLS2_k127_2096270_5	1346791.M529_07235	2.368e-37	156.0	COG1917@1|root,COG1917@2|Bacteria,1NTJ5@1224|Proteobacteria,2UP17@28211|Alphaproteobacteria,2K9RX@204457|Sphingomonadales	204457|Sphingomonadales	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2096270_0	452662.SJA_C2-00890	1.179e-123	409.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U3G1@28211|Alphaproteobacteria,2K3ZD@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
TLS2_k127_2096270_11	426355.Mrad2831_1233	1.454e-06	59.0	29FDW@1|root,2ZXKR@2|Bacteria,1PQE3@1224|Proteobacteria,2V2T4@28211|Alphaproteobacteria,1JYW7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2096270_8	1340493.JNIF01000003_gene4040	7.638e-35	136.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	rbpA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
TLS2_k127_2096270_4	525897.Dbac_2532	1.247e-39	148.0	COG4115@1|root,COG4115@2|Bacteria,1MZBP@1224|Proteobacteria,42UX7@68525|delta/epsilon subdivisions,2WR46@28221|Deltaproteobacteria,2MFZZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	TIGRFAM addiction module toxin, Txe YoeB family	-	-	-	ko:K19158	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	YoeB_toxin
TLS2_k127_2096270_7	234267.Acid_3908	6.459e-35	135.0	COG2161@1|root,COG2161@2|Bacteria	2|Bacteria	D	toxin-antitoxin pair type II binding	-	-	2.3.1.15	ko:K08591,ko:K19159	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko02048	-	-	-	PhdYeFM_antitox
TLS2_k127_2096270_2	1121127.JAFA01000031_gene4654	3.298e-91	308.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2VJ40@28216|Betaproteobacteria,1K4VW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_2096270_9	518766.Rmar_0977	1.874e-30	133.0	COG0358@1|root,COG0358@2|Bacteria,4NENT@976|Bacteroidetes,1FJ4P@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
TLS2_k127_2096270_3	350054.Mflv_4645	3.422e-44	175.0	COG4974@1|root,COG4974@2|Bacteria,2I9ZX@201174|Actinobacteria,2374G@1762|Mycobacteriaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_2096270_6	350058.Mvan_1114	3.225e-35	149.0	COG4974@1|root,COG4974@2|Bacteria,2IBD6@201174|Actinobacteria,236NP@1762|Mycobacteriaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_2096270_10	1267533.KB906740_gene268	5.94e-10	66.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria	57723|Acidobacteria	KU	WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_2096273_3	1340493.JNIF01000004_gene333	3.755e-109	360.0	COG0405@1|root,COG0405@2|Bacteria,3Y2N0@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_2096273_0	234267.Acid_4607	0.0	1272.0	COG3250@1|root,COG3250@2|Bacteria,3Y47P@57723|Acidobacteria	57723|Acidobacteria	G	Beta galactosidase small chain	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TLS2_k127_2096273_2	204669.Acid345_2979	1.008e-210	674.0	COG1680@1|root,COG1680@2|Bacteria,3Y3T0@57723|Acidobacteria,2JHSK@204432|Acidobacteriia	204432|Acidobacteriia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_2096273_1	1340493.JNIF01000003_gene3892	2.15e-238	762.0	COG1452@1|root,COG1452@2|Bacteria,3Y37B@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Organic solvent tolerance protein	-	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA_C
TLS2_k127_2096676_3	886293.Sinac_4622	1.435e-106	352.0	COG3119@1|root,COG3119@2|Bacteria,2IYNZ@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_2096676_0	234267.Acid_6855	2.571e-228	719.0	COG3119@1|root,COG3119@2|Bacteria,3Y7MP@57723|Acidobacteria	57723|Acidobacteria	P	PFAM Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_2096676_2	1121035.AUCH01000001_gene1884	9.618e-107	357.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2VJVZ@28216|Betaproteobacteria,2KUM2@206389|Rhodocyclales	206389|Rhodocyclales	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
TLS2_k127_2096676_1	926550.CLDAP_06290	3.302e-117	382.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	ytaP	-	-	-	-	-	-	-	-	-	-	-	AXE1,Abhydrolase_7,DLH,Peptidase_S15,Peptidase_S9
TLS2_k127_209671_1	1101191.KI912577_gene264	2.107e-39	154.0	COG1819@1|root,COG1819@2|Bacteria,1MVI7@1224|Proteobacteria,2TU9H@28211|Alphaproteobacteria,1JTBS@119045|Methylobacteriaceae	28211|Alphaproteobacteria	CG	PFAM glycosyl transferase family 28	-	-	2.4.1.173	ko:K05841	-	-	-	-	ko00000,ko01000,ko01003	-	GT1	-	Glyco_tran_28_C,Glyco_transf_28,UDPGT
TLS2_k127_209671_2	1194972.MVAC_01875	4.216e-13	79.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria,2349S@1762|Mycobacteriaceae	201174|Actinobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	pdhC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_209671_0	1265505.ATUG01000002_gene1608	9.768e-47	174.0	COG1819@1|root,COG1819@2|Bacteria,1MVI7@1224|Proteobacteria,42UK8@68525|delta/epsilon subdivisions,2WQG7@28221|Deltaproteobacteria,2MM4N@213118|Desulfobacterales	28221|Deltaproteobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,Glyco_transf_28,UDPGT
TLS2_k127_2100151_4	1267535.KB906767_gene2434	1.224e-12	68.0	COG0758@1|root,COG0758@2|Bacteria,3Y42M@57723|Acidobacteria,2JI6N@204432|Acidobacteriia	204432|Acidobacteriia	LU	DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
TLS2_k127_2100151_1	671143.DAMO_0060	2.062e-288	906.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,2NNS8@2323|unclassified Bacteria	2|Bacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.2	ko:K03168,ko:K07479	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,zf-C4_Topoisom
TLS2_k127_2100151_0	234267.Acid_1593	1.343e-312	977.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_1593|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2100151_2	1340493.JNIF01000003_gene1785	1.298e-149	483.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_2100151_3	401053.AciPR4_2893	2.43e-25	111.0	COG3547@1|root,COG3547@2|Bacteria,3Y5SI@57723|Acidobacteria,2JKWK@204432|Acidobacteriia	204432|Acidobacteriia	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_2103016_1	234267.Acid_7075	4.406e-84	290.0	COG0037@1|root,COG0037@2|Bacteria,3Y2F2@57723|Acidobacteria	57723|Acidobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
TLS2_k127_2103016_5	448385.sce3945	1.799e-23	103.0	COG2261@1|root,COG2261@2|Bacteria,1NGEB@1224|Proteobacteria,42VUV@68525|delta/epsilon subdivisions,2WS8X@28221|Deltaproteobacteria,2Z2QK@29|Myxococcales	28221|Deltaproteobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS2_k127_2103016_4	1499967.BAYZ01000114_gene2909	3.444e-24	113.0	COG1269@1|root,COG1269@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	epsH	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH,Peptidase_M28
TLS2_k127_2103016_3	344747.PM8797T_17237	1.155e-67	240.0	COG0657@1|root,COG0657@2|Bacteria,2IYY7@203682|Planctomycetes	203682|Planctomycetes	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS2_k127_2103016_0	234267.Acid_2745	2.325e-158	506.0	COG0082@1|root,COG0082@2|Bacteria,3Y2Z8@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
TLS2_k127_2104179_4	1267535.KB906767_gene2601	8.142e-23	102.0	COG0265@1|root,COG0265@2|Bacteria,3Y3HE@57723|Acidobacteria,2JHN5@204432|Acidobacteriia	204432|Acidobacteriia	O	peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_2104179_2	234267.Acid_4781	2.513e-70	243.0	COG0237@1|root,COG0237@2|Bacteria,3Y4R2@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
TLS2_k127_2104179_0	1267535.KB906767_gene2599	2.611e-124	405.0	COG0190@1|root,COG0190@2|Bacteria,3Y2IN@57723|Acidobacteria,2JMQ0@204432|Acidobacteriia	204432|Acidobacteriia	F	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	-	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
TLS2_k127_2104179_1	234267.Acid_7250	6.869e-71	243.0	COG0386@1|root,COG0386@2|Bacteria,3Y4B8@57723|Acidobacteria	57723|Acidobacteria	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
TLS2_k127_2104179_3	1380600.AUYN01000009_gene1077	1.432e-26	116.0	COG2133@1|root,COG2133@2|Bacteria,4NF61@976|Bacteroidetes	976|Bacteroidetes	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
TLS2_k127_2106581_0	1111069.TCCBUS3UF1_8630	1.664e-126	416.0	COG0562@1|root,COG0562@2|Bacteria,1WI1X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	UDP-galactopyranose mutase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	GLF,NAD_binding_8
TLS2_k127_2106581_3	1229172.JQFA01000004_gene1734	5.025e-78	275.0	COG1442@1|root,COG1442@2|Bacteria,1G27A@1117|Cyanobacteria,1H7A8@1150|Oscillatoriales	1117|Cyanobacteria	M	glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2106581_2	111780.Sta7437_2610	4.047e-89	306.0	COG1216@1|root,COG1216@2|Bacteria,1G3XC@1117|Cyanobacteria	1117|Cyanobacteria	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_2106581_6	99598.Cal7507_5313	1.119e-34	149.0	COG4421@1|root,COG4421@2|Bacteria	2|Bacteria	G	Protein of unknown function (DUF563)	-	-	-	-	-	-	-	-	-	-	-	-	DUF563
TLS2_k127_2106581_1	111780.Sta7437_2609	6.554e-105	357.0	COG0438@1|root,COG0438@2|Bacteria,1GA0D@1117|Cyanobacteria	1117|Cyanobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_2106581_4	926549.KI421517_gene1695	9.33e-54	203.0	COG1216@1|root,COG1216@2|Bacteria,4NIW6@976|Bacteroidetes,47PUF@768503|Cytophagia	976|Bacteroidetes	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_2106581_5	240016.ABIZ01000001_gene1070	4.273e-39	156.0	COG4122@1|root,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24,Sulfotransfer_2,TylF,WbqC
TLS2_k127_2107687_4	1267535.KB906767_gene248	1.135e-147	473.0	COG0115@1|root,COG0115@2|Bacteria,3Y32X@57723|Acidobacteria,2JI58@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS2_k127_2107687_5	1340493.JNIF01000004_gene944	4.858e-97	333.0	COG4783@1|root,COG4783@2|Bacteria,3Y6B5@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS2_k127_2107687_6	234267.Acid_0991	5.693e-54	196.0	COG0637@1|root,COG0637@2|Bacteria,3Y49E@57723|Acidobacteria	57723|Acidobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS2_k127_2107687_7	757424.Hsero_3054	1.35e-08	62.0	COG0628@1|root,COG0628@2|Bacteria,1NFG3@1224|Proteobacteria,2W1HS@28216|Betaproteobacteria,476TH@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_2107687_1	1267535.KB906767_gene3954	6.874e-252	785.0	COG4799@1|root,COG4799@2|Bacteria,3Y3DC@57723|Acidobacteria,2JIP2@204432|Acidobacteriia	204432|Acidobacteriia	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
TLS2_k127_2107687_3	1123242.JH636436_gene641	8.7e-149	484.0	COG3119@1|root,COG3119@2|Bacteria,2IX0S@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_2107687_2	234267.Acid_3143	4.132e-239	755.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	glgX	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
TLS2_k127_2107687_0	671143.DAMO_0621	0.0	1341.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2	-	-	Glyco_hydro_63
TLS2_k127_2108712_1	208444.JNYY01000008_gene8612	2.864e-82	293.0	COG0265@1|root,COG0265@2|Bacteria,2ICC4@201174|Actinobacteria,4E1VC@85010|Pseudonocardiales	201174|Actinobacteria	O	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2108712_0	457421.CBFG_01460	4.74e-96	330.0	COG3119@1|root,COG3119@2|Bacteria,1TQEP@1239|Firmicutes,2482B@186801|Clostridia	186801|Clostridia	P	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_2109129_0	234267.Acid_7947	1.205e-252	805.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_2109129_1	1382359.JIAL01000001_gene2543	3.798e-149	490.0	COG2755@1|root,COG2755@2|Bacteria,3Y2P4@57723|Acidobacteria,2JHZN@204432|Acidobacteriia	204432|Acidobacteriia	E	Pfam:DUF303	-	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	SASA
TLS2_k127_2109129_3	251221.35214330	1.686e-122	409.0	COG1819@1|root,COG1819@2|Bacteria,1G3IM@1117|Cyanobacteria	1117|Cyanobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,Glyco_transf_28,UDPGT
TLS2_k127_2109129_2	234267.Acid_3190	2.943e-126	414.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,3Y2NW@57723|Acidobacteria	57723|Acidobacteria	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
TLS2_k127_2109129_5	1267535.KB906767_gene1327	8.301e-73	248.0	2F1AE@1|root,33UBD@2|Bacteria,3Y7PJ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2109129_6	234267.Acid_4961	4.996e-57	204.0	COG2110@1|root,COG2110@2|Bacteria,3Y4Y6@57723|Acidobacteria	57723|Acidobacteria	S	Appr-1'-p processing enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Macro
TLS2_k127_2109129_4	234267.Acid_0128	4.688e-77	263.0	COG0634@1|root,COG0634@2|Bacteria,3Y2FD@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS2_k127_2109129_7	234267.Acid_0127	3.358e-33	129.0	COG1102@1|root,COG1102@2|Bacteria	2|Bacteria	F	Psort location Cytoplasmic, score	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Cytidylate_kin2,GAF_2,Pribosyltran
TLS2_k127_2113572_3	247490.KSU1_C0122	4.829e-23	112.0	COG3613@1|root,COG3613@2|Bacteria,2J12J@203682|Planctomycetes	203682|Planctomycetes	F	nucleoside 2-deoxyribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2113572_4	743299.Acife_1157	3.022e-21	94.0	COG2442@1|root,COG2442@2|Bacteria,1N7GJ@1224|Proteobacteria,1T974@1236|Gammaproteobacteria,2NDZF@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
TLS2_k127_2113572_2	28072.Nos7524_4682	1.042e-23	104.0	COG4634@1|root,COG4634@2|Bacteria,1G6AG@1117|Cyanobacteria,1HSRN@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2113572_1	1140.Synpcc7942_0117	1.833e-36	152.0	2CFPC@1|root,31SN4@2|Bacteria,1G8CW@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2113572_5	378806.STAUR_6091	5.442e-08	63.0	2DR6B@1|root,33ACQ@2|Bacteria,1NI4T@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2113572_0	1267535.KB906767_gene1540	4.213e-90	319.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_2114213_1	1267535.KB906767_gene4646	2.848e-136	443.0	COG0626@1|root,COG0626@2|Bacteria,3Y2K5@57723|Acidobacteria,2JHVD@204432|Acidobacteriia	204432|Acidobacteriia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48,4.4.1.1,4.4.1.2,4.4.1.8	ko:K01739,ko:K01758,ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338,M00609	R00782,R00999,R01001,R01283,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00487,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02814,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
TLS2_k127_2114213_0	1340493.JNIF01000003_gene3625	3.254e-138	447.0	COG2084@1|root,COG2084@2|Bacteria,3Y45W@57723|Acidobacteria	57723|Acidobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_2120270_2	1340493.JNIF01000004_gene731	2.236e-114	384.0	COG0642@1|root,COG4252@1|root,COG2205@2|Bacteria,COG4252@2|Bacteria	2|Bacteria	T	Chase2 domain	phoR_2	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HATPase_c,HisKA,PAS_4
TLS2_k127_2120270_3	1340493.JNIF01000004_gene730	9.912e-111	371.0	COG0006@1|root,COG0006@2|Bacteria,3Y36W@57723|Acidobacteria	57723|Acidobacteria	E	peptidase M24B X-Pro dipeptidase aminopeptidase domain protein	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
TLS2_k127_2120270_4	1267535.KB906767_gene4788	8.624e-91	308.0	COG2755@1|root,COG2755@2|Bacteria,3Y4BD@57723|Acidobacteria,2JMAI@204432|Acidobacteriia	204432|Acidobacteriia	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS2_k127_2120270_1	497964.CfE428DRAFT_1242	2.68e-166	532.0	COG0823@1|root,COG0823@2|Bacteria,46SJJ@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2120270_0	234267.Acid_4983	2.823e-212	672.0	COG1620@1|root,COG1620@2|Bacteria,3Y2ZA@57723|Acidobacteria	57723|Acidobacteria	C	L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
TLS2_k127_2122819_1	278963.ATWD01000001_gene2569	2.644e-19	95.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y2Q2@57723|Acidobacteria,2JIEC@204432|Acidobacteriia	204432|Acidobacteriia	KU	WD40-like Beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_2122819_0	234267.Acid_5457	0.0	1198.0	COG0085@1|root,COG0085@2|Bacteria,3Y36G@57723|Acidobacteria	57723|Acidobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
TLS2_k127_2125195_1	1267535.KB906767_gene566	3.93e-71	243.0	COG0745@1|root,COG0745@2|Bacteria,3Y38C@57723|Acidobacteria,2JIPX@204432|Acidobacteriia	204432|Acidobacteriia	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483,ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_2125195_3	886293.Sinac_4161	2.051e-26	123.0	COG2823@1|root,COG2823@2|Bacteria	2|Bacteria	S	hyperosmotic response	mcsS	-	-	-	-	-	-	-	-	-	-	-	BON,MS_channel,Polyketide_cyc
TLS2_k127_2125195_2	234267.Acid_0752	3.055e-32	141.0	COG0517@1|root,COG0517@2|Bacteria,3Y8IB@57723|Acidobacteria	57723|Acidobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_2125195_0	1267535.KB906767_gene604	3.396e-297	922.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3Y37Y@57723|Acidobacteria,2JI9E@204432|Acidobacteriia	204432|Acidobacteriia	E	Vitamin B12 dependent methionine synthase activation	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TLS2_k127_2125524_8	1442599.JAAN01000044_gene2885	7.526e-39	153.0	COG2871@1|root,COG3182@1|root,COG2871@2|Bacteria,COG3182@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,1X6HX@135614|Xanthomonadales	135614|Xanthomonadales	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,NAD_binding_1,PepSY_TM
TLS2_k127_2125524_14	1502852.FG94_04180	4.272e-14	80.0	COG3182@1|root,COG3182@2|Bacteria,1PHU6@1224|Proteobacteria,2W6TG@28216|Betaproteobacteria,4776F@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	PepSY-associated TM region	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_TM
TLS2_k127_2125524_11	1280688.AUJB01000009_gene1634	1.305e-28	125.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,3NHPS@46205|Pseudobutyrivibrio	186801|Clostridia	D	Cellulose biosynthesis protein BcsQ	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS2_k127_2125524_16	411490.ANACAC_01270	3.134e-05	48.0	COG0789@1|root,COG0789@2|Bacteria,1TQ78@1239|Firmicutes,247ZI@186801|Clostridia	186801|Clostridia	K	transcriptional regulator, MerR family	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_2125524_9	1267535.KB906767_gene4915	3.305e-29	133.0	COG3307@1|root,COG3307@2|Bacteria,3Y88V@57723|Acidobacteria	57723|Acidobacteria	M	O-antigen ligase like membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TLS2_k127_2125524_6	234267.Acid_1214	2.625e-62	232.0	COG2148@1|root,COG2148@2|Bacteria,3Y4JY@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
TLS2_k127_2125524_4	234267.Acid_4658	1.785e-113	383.0	COG0472@1|root,COG0472@2|Bacteria,3Y5GB@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
TLS2_k127_2125524_0	234267.Acid_6320	3.398e-240	764.0	COG0443@1|root,COG0443@2|Bacteria,3Y2XU@57723|Acidobacteria	2|Bacteria	O	Heat shock 70 kDa protein	-	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TLS2_k127_2125524_7	234267.Acid_6319	2.339e-48	189.0	COG0576@1|root,COG0576@2|Bacteria	2|Bacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	-	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS2_k127_2125524_10	234267.Acid_6318	1.097e-28	121.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DnaJ
TLS2_k127_2125524_5	234267.Acid_0279	1.461e-67	237.0	COG0500@1|root,COG2226@2|Bacteria,3Y7T9@57723|Acidobacteria	57723|Acidobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_2125524_12	1202768.JROF01000015_gene1059	2.028e-22	112.0	arCOG00567@1|root,arCOG00567@2157|Archaea,2XVU1@28890|Euryarchaeota,23UZV@183963|Halobacteria	183963|Halobacteria	M	glycosyl transferase family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_2125524_1	234267.Acid_4597	2.359e-204	645.0	COG0677@1|root,COG0677@2|Bacteria,3Y30B@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.136	ko:K13015	ko00520,map00520	-	R00421	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS2_k127_2125524_2	234267.Acid_7476	3.712e-132	434.0	COG0381@1|root,COG0381@2|Bacteria,3Y50B@57723|Acidobacteria	57723|Acidobacteria	M	UDP-N-acetylglucosamine 2-epimerase	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
TLS2_k127_2125524_15	42256.RradSPS_2921	1.311e-10	74.0	COG5534@1|root,COG5534@2|Bacteria	2|Bacteria	L	Replication initiator protein	repA	-	-	-	-	-	-	-	-	-	-	-	RPA
TLS2_k127_2127226_4	716928.AJQT01000049_gene1915	6.489e-48	174.0	COG3546@1|root,COG3546@2|Bacteria,1MUHB@1224|Proteobacteria,2TUU8@28211|Alphaproteobacteria,4BD7C@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Catalase	katN	-	-	ko:K07217	-	-	-	-	ko00000	-	-	-	DUF892,Mn_catalase
TLS2_k127_2127226_0	234267.Acid_7854	7.821e-245	766.0	COG0606@1|root,COG0606@2|Bacteria,3Y3JA@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
TLS2_k127_2127226_2	234267.Acid_4374	2.751e-123	398.0	COG0588@1|root,COG0588@2|Bacteria,3Y6SZ@57723|Acidobacteria	57723|Acidobacteria	F	Phosphoglycerate mutase family	-	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
TLS2_k127_2127226_1	1267535.KB906767_gene2427	2.458e-219	687.0	COG0148@1|root,COG0148@2|Bacteria,3Y2IT@57723|Acidobacteria,2JI6Q@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TLS2_k127_2127226_3	234267.Acid_4755	5.894e-71	262.0	COG0577@1|root,COG0577@2|Bacteria,3Y78V@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_2135723_0	258594.RPA4000	2.111e-68	261.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	MA20_09880	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,SAM_1
TLS2_k127_2135723_1	1380391.JIAS01000020_gene1600	9.685e-58	213.0	COG3482@1|root,COG3482@2|Bacteria,1QG2J@1224|Proteobacteria,2TUJJ@28211|Alphaproteobacteria,2JSII@204441|Rhodospirillales	204441|Rhodospirillales	S	TfuA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TfuA
TLS2_k127_2135723_2	448385.sce7124	2.096e-27	118.0	COG1944@1|root,COG1944@2|Bacteria,1N5NV@1224|Proteobacteria,42VNR@68525|delta/epsilon subdivisions,2WSCG@28221|Deltaproteobacteria,2YXER@29|Myxococcales	28221|Deltaproteobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
TLS2_k127_2140605_1	1379270.AUXF01000007_gene1065	3.963e-104	354.0	COG1055@1|root,COG1055@2|Bacteria,1ZU8M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	MatC_N
TLS2_k127_2140605_0	357808.RoseRS_3858	2.887e-278	886.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2G5ZQ@200795|Chloroflexi,376AA@32061|Chloroflexia	32061|Chloroflexia	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
TLS2_k127_2140605_2	1173264.KI913949_gene3925	3.019e-65	234.0	COG0436@1|root,COG0436@2|Bacteria,1G0M8@1117|Cyanobacteria,1H7KD@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Aminotransferase class I and II	aspC	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_2141480_1	234267.Acid_4968	3.097e-234	747.0	COG0308@1|root,COG0308@2|Bacteria,3Y31F@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
TLS2_k127_2141480_3	1382359.JIAL01000001_gene2348	1.629e-78	283.0	2CK1E@1|root,33T2R@2|Bacteria,3Y7DJ@57723|Acidobacteria,2JM38@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2141480_0	1267535.KB906767_gene1307	0.0	1340.0	COG0178@1|root,COG0178@2|Bacteria,3Y3PA@57723|Acidobacteria,2JISM@204432|Acidobacteriia	204432|Acidobacteriia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_2141480_4	234267.Acid_7304	3.726e-26	112.0	COG1828@1|root,COG1828@2|Bacteria,3Y5NE@57723|Acidobacteria	57723|Acidobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
TLS2_k127_2141480_2	234267.Acid_3355	1.913e-113	376.0	COG4251@1|root,COG4251@2|Bacteria,3Y72P@57723|Acidobacteria	57723|Acidobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_2,PAS_4,PHY
TLS2_k127_2141480_5	1354722.JQLS01000001_gene4654	1.963e-05	47.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2TUQ1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_2145797_2	749927.AMED_3672	3.965e-40	156.0	COG0596@1|root,COG0596@2|Bacteria,2I8ZB@201174|Actinobacteria,4EAA2@85010|Pseudonocardiales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_2145797_0	348780.NP_0178A	8.934e-87	299.0	COG0388@1|root,arCOG00126@2157|Archaea,2XVTM@28890|Euryarchaeota,23UUE@183963|Halobacteria	183963|Halobacteria	S	Carbon-nitrogen hydrolase	nitB	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
TLS2_k127_2145797_1	998674.ATTE01000001_gene4147	6.937e-47	173.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1T58V@1236|Gammaproteobacteria,463WP@72273|Thiotrichales	1236|Gammaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_2151138_3	401053.AciPR4_2893	4.231e-30	120.0	COG3547@1|root,COG3547@2|Bacteria,3Y5SI@57723|Acidobacteria,2JKWK@204432|Acidobacteriia	204432|Acidobacteriia	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_2151138_1	269482.Bcep1808_4285	2.47e-107	362.0	COG3328@1|root,COG3328@2|Bacteria,1R81T@1224|Proteobacteria,2W75T@28216|Betaproteobacteria,1KDWC@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase, mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
TLS2_k127_2151138_2	398525.KB900701_gene2369	1.31e-33	133.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2TUNK@28211|Alphaproteobacteria,3JSHP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_2151138_0	1121939.L861_14950	9.33e-121	394.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,1RRDD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_2151138_4	1173023.KE650771_gene568	5.207e-10	62.0	COG0277@1|root,COG0277@2|Bacteria,1GAQ7@1117|Cyanobacteria	1117|Cyanobacteria	C	FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_2160072_1	997346.HMPREF9374_3885	2.005e-20	91.0	COG0346@1|root,COG0346@2|Bacteria,1V36W@1239|Firmicutes,4IQ29@91061|Bacilli	91061|Bacilli	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_2160072_0	1123511.KB905859_gene2200	2.628e-151	482.0	COG2267@1|root,COG2267@2|Bacteria,1TPI0@1239|Firmicutes,4H3TE@909932|Negativicutes	909932|Negativicutes	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_2163317_1	379066.GAU_3392	2.729e-89	303.0	COG3319@1|root,COG3319@2|Bacteria,1ZUQK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2163317_0	234267.Acid_4305	6.12e-115	375.0	2DBN7@1|root,2ZA2Y@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
TLS2_k127_2163317_3	1340493.JNIF01000003_gene1760	6.76e-13	72.0	29587@1|root,2ZSKP@2|Bacteria,3Y8TQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2163317_4	1267535.KB906767_gene2170	2.067e-08	60.0	29587@1|root,2ZSKP@2|Bacteria,3Y8TQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2163317_2	1267535.KB906767_gene2172	3.233e-71	246.0	COG0705@1|root,COG0705@2|Bacteria,3Y45U@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS2_k127_2179986_3	930171.Asphe3_22160	4.279e-35	142.0	COG2801@1|root,COG2801@2|Bacteria,2GNRT@201174|Actinobacteria	201174|Actinobacteria	L	PFAM Integrase catalytic	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve
TLS2_k127_2179986_0	880072.Desac_2842	1.187e-64	230.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,42MUE@68525|delta/epsilon subdivisions,2WJFZ@28221|Deltaproteobacteria,2MR9K@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve
TLS2_k127_2179986_4	671143.DAMO_0400	9.748e-16	81.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
TLS2_k127_2179986_2	298653.Franean1_2887	2.089e-42	160.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4ERUS@85013|Frankiales	201174|Actinobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
TLS2_k127_2179986_1	1299327.I546_5558	1.409e-50	182.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,23B0M@1762|Mycobacteriaceae	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
TLS2_k127_2184703_6	666685.R2APBS1_0498	3.415e-71	249.0	2CI52@1|root,2ZC5H@2|Bacteria,1R9WI@1224|Proteobacteria,1S37R@1236|Gammaproteobacteria,1X6EM@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2184703_5	1237149.C900_01837	2.762e-89	329.0	COG3064@1|root,COG3064@2|Bacteria,4PNCV@976|Bacteroidetes	976|Bacteroidetes	M	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
TLS2_k127_2184703_1	485913.Krac_5970	6.02e-190	620.0	COG0464@1|root,COG0464@2|Bacteria,2G67S@200795|Chloroflexi	200795|Chloroflexi	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
TLS2_k127_2184703_2	1521187.JPIM01000011_gene2632	1.496e-112	379.0	28PII@1|root,2ZC8H@2|Bacteria,2G926@200795|Chloroflexi,377FI@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF4255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4255
TLS2_k127_2184703_7	1463917.JODC01000020_gene9238	3.909e-47	178.0	2AAD4@1|root,30ZP1@2|Bacteria,2HPD2@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2184703_4	1123392.AQWL01000008_gene1223	3.518e-97	320.0	2DB76@1|root,2Z7JZ@2|Bacteria,1R41X@1224|Proteobacteria,2VMX8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
TLS2_k127_2184703_0	118166.JH976537_gene401	4.714e-190	610.0	COG3497@1|root,COG3497@2|Bacteria,1G41S@1117|Cyanobacteria,1H9RA@1150|Oscillatoriales	1117|Cyanobacteria	S	Phage tail sheath protein	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
TLS2_k127_2184703_9	644282.Deba_0073	1.329e-17	87.0	COG2336@1|root,COG2336@2|Bacteria,1QABF@1224|Proteobacteria,42Y1B@68525|delta/epsilon subdivisions,2WTB4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Transcriptional regulator antitoxin, MazE	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
TLS2_k127_2184703_8	697282.Mettu_1892	3.228e-41	154.0	COG2337@1|root,COG2337@2|Bacteria,1PVJ9@1224|Proteobacteria,1TM47@1236|Gammaproteobacteria,1XGTH@135618|Methylococcales	2|Bacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	chpA	GO:0001558,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0022607,GO:0030308,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0042802,GO:0042803,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044877,GO:0045926,GO:0046483,GO:0046700,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051259,GO:0051291,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
TLS2_k127_2184703_3	1340493.JNIF01000003_gene3635	4.933e-98	323.0	COG2303@1|root,COG2303@2|Bacteria,3Y6FS@57723|Acidobacteria	57723|Acidobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_2191984_4	1267535.KB906767_gene479	6.285e-21	93.0	COG0739@1|root,COG0739@2|Bacteria,3Y3N4@57723|Acidobacteria,2JHPR@204432|Acidobacteriia	204432|Acidobacteriia	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_2191984_0	234267.Acid_0174	5.188e-160	516.0	COG0673@1|root,COG0673@2|Bacteria,3Y4RG@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_2191984_1	1267535.KB906767_gene337	1.588e-142	476.0	COG4289@1|root,COG4289@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2264)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2264
TLS2_k127_2191984_5	633148.Tagg_0915	4.513e-15	81.0	COG1148@1|root,arCOG10656@2157|Archaea,2XS37@28889|Crenarchaeota	28889|Crenarchaeota	C	COGs COG1148 Heterodisulfide reductase subunit A and related polyferredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2191984_3	204669.Acid345_1808	5.213e-64	226.0	COG1014@1|root,COG1014@2|Bacteria,3Y6SM@57723|Acidobacteria	57723|Acidobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
TLS2_k127_2191984_2	234267.Acid_6989	1.27e-127	412.0	COG1013@1|root,COG1013@2|Bacteria,3Y514@57723|Acidobacteria	57723|Acidobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
TLS2_k127_2191984_6	749414.SBI_01326	1.454e-07	56.0	COG4948@1|root,COG4948@2|Bacteria,2GT81@201174|Actinobacteria	201174|Actinobacteria	M	mandelate racemase muconate lactonizing	-	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0009056,GO:0016052,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044238,GO:0046872,GO:0047929,GO:0071704,GO:1901575	4.1.2.21,4.2.1.6,4.2.1.8	ko:K01631,ko:K01684,ko:K08323	ko00040,ko00052,ko01100,ko01120,map00040,map00052,map01100,map01120	M00061,M00552	R01064,R03033,R05606	RC00307,RC00435,RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_219851_2	1340493.JNIF01000002_gene1240	1.346e-110	374.0	COG0438@1|root,COG0438@2|Bacteria,3Y8FM@57723|Acidobacteria	2|Bacteria	M	Glycosyl transferases group 1	-	-	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100	-	R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_219851_3	941449.dsx2_3281	1.205e-95	323.0	COG1215@1|root,COG1215@2|Bacteria,1QTWU@1224|Proteobacteria,43CR1@68525|delta/epsilon subdivisions,2X7YK@28221|Deltaproteobacteria,2MHAW@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
TLS2_k127_219851_1	1090319.KE386571_gene441	4.207e-120	394.0	COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,2U0P8@28211|Alphaproteobacteria,2K007@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_219851_4	234267.Acid_1127	2.25e-28	119.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_219851_5	1267535.KB906767_gene4499	2.473e-11	69.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria,2JJS7@204432|Acidobacteriia	204432|Acidobacteriia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_219851_0	525904.Tter_2189	3.025e-140	457.0	COG1215@1|root,COG1215@2|Bacteria,2NPD4@2323|unclassified Bacteria	2|Bacteria	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
TLS2_k127_2199688_4	391625.PPSIR1_16130	7.184e-64	229.0	COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,42Y58@68525|delta/epsilon subdivisions,2WTVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
TLS2_k127_2199688_1	344747.PM8797T_00507	1.772e-224	711.0	COG1413@1|root,COG3119@1|root,COG1413@2|Bacteria,COG3119@2|Bacteria,2IYFZ@203682|Planctomycetes	203682|Planctomycetes	CP	COG3119 Arylsulfatase A	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
TLS2_k127_2199688_8	1279009.ADICEAN_02760	7.901e-33	132.0	COG2318@1|root,COG2318@2|Bacteria,4NRAP@976|Bacteroidetes,47NZT@768503|Cytophagia	976|Bacteroidetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_2199688_6	234267.Acid_5628	2.224e-52	192.0	COG1214@1|root,COG1214@2|Bacteria,3Y5ED@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Peptidase M22, glycoprotease	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
TLS2_k127_2199688_2	234267.Acid_5629	1.013e-201	646.0	COG5512@1|root,COG5512@2|Bacteria,3Y7CI@57723|Acidobacteria	57723|Acidobacteria	S	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
TLS2_k127_2199688_0	1121904.ARBP01000032_gene2005	3.492e-271	854.0	COG1913@1|root,COG1913@2|Bacteria,4PMAZ@976|Bacteroidetes,47JTT@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
TLS2_k127_2199688_5	234267.Acid_4434	1.813e-52	199.0	COG1835@1|root,COG1835@2|Bacteria	2|Bacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS2_k127_2199688_3	1267534.KB906757_gene993	1.342e-137	449.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	MA20_35850	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_2199688_9	357808.RoseRS_3423	3.953e-31	134.0	COG2518@1|root,COG2518@2|Bacteria	2|Bacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	Met_10,Methyltransf_21,rRNA_methylase
TLS2_k127_2199688_7	1340493.JNIF01000003_gene2360	5.267e-39	147.0	COG3279@1|root,COG3279@2|Bacteria	2|Bacteria	KT	phosphorelay signal transduction system	coxC	GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007	-	ko:K02477,ko:K07705,ko:K21696	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022,ko03000	-	-	-	LytTR,MHYT,Response_reg
TLS2_k127_2202863_4	1267535.KB906767_gene4402	2.416e-57	211.0	COG1414@1|root,COG1414@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS2_k127_2202863_1	1089547.KB913013_gene3347	2.783e-100	345.0	COG0673@1|root,COG0673@2|Bacteria,4NF3G@976|Bacteroidetes,47MH7@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_2202863_3	383372.Rcas_3850	5.905e-72	262.0	COG2133@1|root,COG2133@2|Bacteria,2G90Z@200795|Chloroflexi	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
TLS2_k127_2202863_0	1267535.KB906767_gene4432	5.103e-191	636.0	COG1629@1|root,COG1629@2|Bacteria,3Y620@57723|Acidobacteria,2JKZX@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_2202863_2	1267535.KB906767_gene4408	2.413e-86	291.0	COG0684@1|root,COG0684@2|Bacteria,3Y788@57723|Acidobacteria	57723|Acidobacteria	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
TLS2_k127_2202863_5	525904.Tter_1958	1.192e-30	122.0	COG0129@1|root,COG0129@2|Bacteria,2NNSM@2323|unclassified Bacteria	2|Bacteria	EG	Belongs to the IlvD Edd family	ilvD4	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS2_k127_2203665_4	234267.Acid_2117	3.855e-38	151.0	COG2271@1|root,COG2271@2|Bacteria,3Y6CQ@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
TLS2_k127_2203665_1	234267.Acid_2118	2.089e-158	524.0	COG0438@1|root,COG0438@2|Bacteria,3Y64B@57723|Acidobacteria	2|Bacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
TLS2_k127_2203665_6	1267535.KB906767_gene2204	2.483e-18	100.0	COG0454@1|root,COG0456@2|Bacteria,3Y5KS@57723|Acidobacteria	57723|Acidobacteria	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TLS2_k127_2203665_2	1449126.JQKL01000021_gene89	4.216e-98	340.0	COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,267US@186813|unclassified Clostridiales	186801|Clostridia	P	Cation transport protein	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS2_k127_2203665_3	1047013.AQSP01000135_gene1618	2.557e-47	178.0	COG0569@1|root,COG0569@2|Bacteria,2NPKV@2323|unclassified Bacteria	2|Bacteria	P	TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS2_k127_2203665_0	234267.Acid_3181	3.987e-161	521.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,3Y4W1@57723|Acidobacteria	57723|Acidobacteria	H	synthase	-	-	2.1.1.107,4.2.1.75	ko:K01719,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
TLS2_k127_2203665_5	472759.Nhal_3936	1.661e-36	143.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1WVWF@135613|Chromatiales	135613|Chromatiales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
TLS2_k127_2204012_0	663610.JQKO01000001_gene853	3.829e-242	758.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2TRER@28211|Alphaproteobacteria,3NATI@45404|Beijerinckiaceae	28211|Alphaproteobacteria	G	Carbohydrate phosphorylase	glgP	GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
TLS2_k127_2207047_4	1267533.KB906735_gene4712	5.297e-06	53.0	COG0806@1|root,COG0806@2|Bacteria,3Y51G@57723|Acidobacteria,2JJGA@204432|Acidobacteriia	204432|Acidobacteriia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
TLS2_k127_2207047_2	234267.Acid_2571	2.578e-30	122.0	COG1837@1|root,COG1837@2|Bacteria,3Y5N5@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the UPF0109 family	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
TLS2_k127_2207047_3	1340493.JNIF01000003_gene3702	7.249e-30	121.0	COG0228@1|root,COG0228@2|Bacteria,3Y56G@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TLS2_k127_2207047_0	234267.Acid_2573	9.676e-226	706.0	COG0541@1|root,COG0541@2|Bacteria,3Y3AU@57723|Acidobacteria	57723|Acidobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TLS2_k127_2210171_0	234267.Acid_3559	2.845e-224	724.0	COG0577@1|root,COG0577@2|Bacteria,3Y3Z1@57723|Acidobacteria	234267.Acid_3559|-	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2210171_1	1340493.JNIF01000003_gene3280	3.555e-38	146.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_2210171_2	1185876.BN8_02809	5.283e-21	98.0	2DPXD@1|root,333T1@2|Bacteria,4NZI7@976|Bacteroidetes,47WC4@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_2211338_0	1502851.FG93_00182	5.773e-159	524.0	COG0642@1|root,COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1
TLS2_k127_2226197_3	323261.Noc_1865	5.176e-26	116.0	COG3299@1|root,COG3299@2|Bacteria,1PF9H@1224|Proteobacteria,1SXC0@1236|Gammaproteobacteria,1X1IG@135613|Chromatiales	135613|Chromatiales	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
TLS2_k127_2226197_2	234267.Acid_3845	1.106e-38	151.0	COG0558@1|root,COG0558@2|Bacteria,3Y4S5@57723|Acidobacteria	57723|Acidobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_2226197_0	234267.Acid_1153	9.884e-134	435.0	COG0774@1|root,COG0774@2|Bacteria,3Y40I@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
TLS2_k127_223036_1	234267.Acid_6599	6.818e-76	271.0	COG0577@1|root,COG0577@2|Bacteria,3Y7DQ@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_223036_0	118173.KB235914_gene1175	2.003e-82	297.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,1HH3F@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
TLS2_k127_223036_2	1123393.KB891326_gene181	8.11e-45	166.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2W96U@28216|Betaproteobacteria,1KRRU@119069|Hydrogenophilales	119069|Hydrogenophilales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_2236816_3	1120968.AUBX01000009_gene99	1.326e-69	246.0	COG1735@1|root,COG1735@2|Bacteria,4NJYF@976|Bacteroidetes,47NZQ@768503|Cytophagia	976|Bacteroidetes	S	Phosphotriesterase family	php	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
TLS2_k127_2236816_5	1157708.KB907466_gene605	7.54e-05	52.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHAU@28216|Betaproteobacteria,4AB4Y@80864|Comamonadaceae	28216|Betaproteobacteria	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	PEGA,Pkinase
TLS2_k127_2236816_0	234267.Acid_3596	5.045e-181	586.0	COG1807@1|root,COG1807@2|Bacteria,3Y2T0@57723|Acidobacteria	57723|Acidobacteria	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
TLS2_k127_2236816_1	794903.OPIT5_08065	2.017e-102	349.0	COG4225@1|root,COG4225@2|Bacteria,46YAU@74201|Verrucomicrobia,3K98F@414999|Opitutae	414999|Opitutae	S	Glycosyl Hydrolase Family 88	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
TLS2_k127_2236816_4	107636.JQNK01000009_gene1191	1.75e-20	94.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TRPK@28211|Alphaproteobacteria,36XMM@31993|Methylocystaceae	28211|Alphaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	aatA	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_2236816_2	1306406.ASHX01000001_gene597	2.437e-86	289.0	COG2730@1|root,COG2730@2|Bacteria,2HQAQ@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.123	ko:K05991	-	-	-	-	ko00000,ko01000	-	GH5	-	Cellulase
TLS2_k127_2237492_0	234267.Acid_3318	1.772e-312	971.0	COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_2237492_1	1121481.AUAS01000001_gene4322	9.194e-25	106.0	COG1082@1|root,COG1082@2|Bacteria,4NKFY@976|Bacteroidetes,47N9K@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_2245285_1	234267.Acid_1069	6.196e-77	275.0	COG0840@1|root,COG5278@1|root,COG0840@2|Bacteria,COG5278@2|Bacteria,3Y4VY@57723|Acidobacteria	57723|Acidobacteria	NT	PFAM chemotaxis sensory transducer	-	-	-	ko:K03406,ko:K05874	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,MCPsignal
TLS2_k127_2245285_0	1382304.JNIL01000001_gene3184	3.538e-88	299.0	COG4948@1|root,COG4948@2|Bacteria,1TS0S@1239|Firmicutes,4HC1G@91061|Bacilli	91061|Bacilli	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_2251291_2	886293.Sinac_1154	3.38e-104	341.0	COG2960@1|root,COG2960@2|Bacteria,2J2KP@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
TLS2_k127_2251291_0	234267.Acid_5825	4.371e-170	546.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	moxJ	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,SBP_bac_3
TLS2_k127_2251291_4	1267534.KB906760_gene1289	3.382e-43	166.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
TLS2_k127_2251291_1	1267534.KB906760_gene1290	5.857e-151	509.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y3HX@57723|Acidobacteria,2JHJ9@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS2_k127_2251291_5	1288494.EBAPG3_8130	2.321e-22	102.0	COG3271@1|root,COG3271@2|Bacteria,1PXU9@1224|Proteobacteria,2W4MU@28216|Betaproteobacteria,374DJ@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2251291_3	143224.JQMD01000002_gene3082	4.519e-63	224.0	COG2271@1|root,COG2271@2|Bacteria,4NGCR@976|Bacteroidetes,1HWZ4@117743|Flavobacteriia	976|Bacteroidetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_2257001_3	234267.Acid_5387	2.22e-19	92.0	COG3119@1|root,COG3119@2|Bacteria,3Y5BN@57723|Acidobacteria	57723|Acidobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_2257001_2	937777.Deipe_2442	8.631e-58	211.0	COG5637@1|root,COG5637@2|Bacteria,1WMPC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892,Polyketide_cyc
TLS2_k127_2257001_0	383372.Rcas_2628	3.494e-114	383.0	COG0001@1|root,COG0001@2|Bacteria,2G7SS@200795|Chloroflexi,377Z8@32061|Chloroflexia	2|Bacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_2257001_1	521674.Plim_2944	8.355e-69	243.0	COG1520@1|root,COG1520@2|Bacteria,2IX37@203682|Planctomycetes	203682|Planctomycetes	S	protein kinase related protein	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_2264790_2	1047013.AQSP01000097_gene1952	1.632e-07	63.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,TolB_like
TLS2_k127_2264790_1	1349767.GJA_2580	6.465e-14	79.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2VKKV@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Transcriptional regulator	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_2264790_0	158500.BV97_05376	2.356e-89	312.0	COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,2U4GT@28211|Alphaproteobacteria,2K8WF@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase or inactivated derivative	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
TLS2_k127_2267696_0	234267.Acid_1167	3.109e-205	644.0	COG0304@1|root,COG0304@2|Bacteria,3Y3IS@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS2_k127_2267696_3	240016.ABIZ01000001_gene1476	4.818e-123	403.0	COG0123@1|root,COG0123@2|Bacteria,46SMT@74201|Verrucomicrobia,2IUMK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TLS2_k127_2267696_5	1267535.KB906767_gene3620	4.242e-34	134.0	COG1965@1|root,COG1965@2|Bacteria	2|Bacteria	P	Belongs to the frataxin family	cyaY	GO:0003674,GO:0003824,GO:0004322,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008199,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0016530,GO:0016722,GO:0016724,GO:0018282,GO:0018283,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0033554,GO:0034599,GO:0034986,GO:0036211,GO:0042221,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0050896,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071704,GO:0071840,GO:0098771,GO:0140104,GO:1901564	1.16.3.1	ko:K06202,ko:K19054	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000,ko03029	-	-	iECW_1372.ECW_m4108,iEKO11_1354.EKO11_4552,iWFL_1372.ECW_m4108	Frataxin_Cyay
TLS2_k127_2267696_2	234267.Acid_5926	4.483e-140	453.0	COG0635@1|root,COG0635@2|Bacteria,3Y2ZB@57723|Acidobacteria	57723|Acidobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
TLS2_k127_2267696_1	1340493.JNIF01000003_gene2708	1.339e-143	466.0	COG2008@1|root,COG2008@2|Bacteria,3Y472@57723|Acidobacteria	57723|Acidobacteria	E	aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_2267696_4	402881.Plav_0158	1.887e-92	310.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2TQZG@28211|Alphaproteobacteria,1JN23@119043|Rhodobiaceae	28211|Alphaproteobacteria	IQ	short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_2270913_5	1267535.KB906767_gene3809	8.471e-43	162.0	COG0457@1|root,COG0457@2|Bacteria	1267535.KB906767_gene3809|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2270913_7	272134.KB731324_gene1337	6.625e-26	113.0	COG1670@1|root,COG1670@2|Bacteria,1G5GV@1117|Cyanobacteria,1HAQ0@1150|Oscillatoriales	1117|Cyanobacteria	J	PFAM Acetyltransferase (GNAT) family	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS2_k127_2270913_6	1267535.KB906767_gene646	2.857e-34	133.0	COG5552@1|root,COG5552@2|Bacteria	2|Bacteria	S	Uncharacterized conserved protein (DUF2277)	MA20_01405	-	-	-	-	-	-	-	-	-	-	-	DUF2277
TLS2_k127_2270913_3	1316936.K678_12252	5.833e-71	248.0	COG2220@1|root,COG2220@2|Bacteria,1NNZA@1224|Proteobacteria,2U6PV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Beta-lactamase superfamily domain	-	-	-	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	M00550	R07677	RC02793	ko00000,ko00001,ko00002,ko01000	-	-	-	LMWPc,Lactamase_B_2,Lactamase_B_3
TLS2_k127_2270913_0	204669.Acid345_4203	1.249e-276	865.0	COG1297@1|root,COG1297@2|Bacteria,3Y2UT@57723|Acidobacteria,2JHIU@204432|Acidobacteriia	204432|Acidobacteriia	S	Oligopeptide transporter OPT	-	-	-	-	-	-	-	-	-	-	-	-	OPT
TLS2_k127_2270913_2	926566.Terro_1495	3.163e-73	261.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
TLS2_k127_2270913_4	1340493.JNIF01000003_gene4833	1.127e-65	242.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
TLS2_k127_2270913_1	1340493.JNIF01000003_gene4834	9.739e-196	624.0	COG3696@1|root,COG3696@2|Bacteria,3Y6AY@57723|Acidobacteria	57723|Acidobacteria	P	AcrB/AcrD/AcrF family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
TLS2_k127_2272703_1	1267535.KB906767_gene1214	3.698e-115	377.0	COG2433@1|root,COG2433@2|Bacteria,3Y7F1@57723|Acidobacteria	57723|Acidobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
TLS2_k127_2272703_2	344747.PM8797T_27954	2.993e-23	108.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,PRiA4_ORF3,zf-IS66
TLS2_k127_2272703_0	234267.Acid_2941	1.877e-142	457.0	2DB88@1|root,2Z7QT@2|Bacteria,3Y61J@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
TLS2_k127_2272703_3	234267.Acid_2940	5.13e-21	92.0	COG3436@1|root,COG3436@2|Bacteria,3Y875@57723|Acidobacteria	2|Bacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
TLS2_k127_2277952_2	234267.Acid_3421	1.759e-63	224.0	COG0791@1|root,COG0791@2|Bacteria,3Y5IG@57723|Acidobacteria	57723|Acidobacteria	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,SPOR
TLS2_k127_2277952_0	1121380.JNIW01000014_gene2412	2.682e-212	668.0	COG1249@1|root,COG1249@2|Bacteria	2|Bacteria	C	cell redox homeostasis	sthA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_2277952_1	1340493.JNIF01000003_gene2185	7.953e-103	340.0	COG2197@1|root,COG2197@2|Bacteria,3Y2WY@57723|Acidobacteria	57723|Acidobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_2277952_3	1267535.KB906767_gene4920	1.126e-51	197.0	COG1629@1|root,COG4771@2|Bacteria,3Y7CC@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_2292073_0	234267.Acid_0858	0.0	1350.0	COG2010@1|root,COG2010@2|Bacteria,3Y6T1@57723|Acidobacteria	57723|Acidobacteria	C	cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_2292073_1	234267.Acid_0859	2.783e-183	578.0	COG4102@1|root,COG4102@2|Bacteria,3Y6RN@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_2293724_2	1125973.JNLC01000014_gene2597	2.173e-08	59.0	COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,2UF5Q@28211|Alphaproteobacteria,3K05I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	CsbD-like	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
TLS2_k127_2293724_0	1121405.dsmv_3003	0.0	4368.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	glycosyltransferase 36 associated	-	-	2.4.1.20	ko:K00702,ko:K13688	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000,ko01003	-	GH94,GT36,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
TLS2_k127_2293724_4	1517416.IDAT_11040	1.663e-05	51.0	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,1RVRF@1236|Gammaproteobacteria,2QFAN@267893|Idiomarinaceae	1236|Gammaproteobacteria	M	Belongs to the ompA family	yiaD	-	-	ko:K12216	-	-	-	-	ko00000,ko02044	3.A.7.9.1	-	-	Gly-zipper_Omp,Gly-zipper_YMGG,OmpA
TLS2_k127_2293724_3	398525.KB900701_gene7630	2.452e-08	60.0	COG2963@1|root,COG2963@2|Bacteria,1N2T5@1224|Proteobacteria,2U9CF@28211|Alphaproteobacteria,3JZF6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
TLS2_k127_2293724_1	330214.NIDE2409	3.049e-11	67.0	COG0489@1|root,COG0489@2|Bacteria	2|Bacteria	D	protein tyrosine kinase activity	epsB	-	2.7.10.1	ko:K08252	-	-	-	-	ko00000,ko01000	-	-	-	AAA_31,CbiA
TLS2_k127_2308757_2	1129374.AJE_15574	2.075e-69	242.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RSG9@1236|Gammaproteobacteria,464W2@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Leuk-A4-hydro_C,Peptidase_M1
TLS2_k127_2308757_1	1340493.JNIF01000003_gene3603	1.01e-178	568.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_2308757_0	1267535.KB906767_gene1536	8.819e-211	696.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_2308757_3	1267535.KB906767_gene5505	1.417e-20	97.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_2309693_1	525244.HMPREF0023_2020	7.695e-26	109.0	COG4737@1|root,COG4737@2|Bacteria,1N7N5@1224|Proteobacteria,1S6BG@1236|Gammaproteobacteria,3NNJM@468|Moraxellaceae	1236|Gammaproteobacteria	S	RelE toxin of RelE / RelB toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	RelE
TLS2_k127_2309693_2	762376.AXYL_06059	8.046e-25	107.0	COG2944@1|root,COG2944@2|Bacteria,1N155@1224|Proteobacteria,2WFUN@28216|Betaproteobacteria,3T4SF@506|Alcaligenaceae	28216|Betaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS2_k127_2309693_3	404589.Anae109_1578	4.27e-14	74.0	2AG2N@1|root,31670@2|Bacteria,1NNB1@1224|Proteobacteria,437DW@68525|delta/epsilon subdivisions,2X2K1@28221|Deltaproteobacteria,2Z2S0@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2309693_0	1380600.AUYN01000001_gene2885	8.369e-83	284.0	COG3540@1|root,COG3540@2|Bacteria,4NFXQ@976|Bacteroidetes,1HY2S@117743|Flavobacteriia	976|Bacteroidetes	P	PhoD-like phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PhoD
TLS2_k127_2313650_0	1123242.JH636434_gene4898	1.148e-118	400.0	COG0642@1|root,COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,2IX8Z@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
TLS2_k127_231473_0	330214.NIDE3125	9.234e-98	325.0	COG2079@1|root,COG2079@2|Bacteria	2|Bacteria	S	2-methylcitrate dehydratase activity	prpD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019679,GO:0019752,GO:0030312,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0047547,GO:0050896,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
TLS2_k127_231473_1	330214.NIDE3102	2.165e-76	263.0	COG1024@1|root,COG1024@2|Bacteria,3J1EP@40117|Nitrospirae	40117|Nitrospirae	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K13767,ko:K13816	ko00071,ko00362,ko01100,ko01120,ko01212,ko02020,ko02024,map00071,map00362,map01100,map01120,map01212,map02020,map02024	M00087	R03026,R04170,R04738,R04740,R04744,R04746	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_231473_2	330214.NIDE3124	3.394e-65	227.0	COG1703@1|root,COG1703@2|Bacteria	2|Bacteria	E	isobutyryl-CoA mutase activity	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS2_k127_2315129_5	1267535.KB906767_gene2557	1.891e-25	109.0	COG0206@1|root,COG0206@2|Bacteria,3Y2WG@57723|Acidobacteria,2JHRJ@204432|Acidobacteriia	204432|Acidobacteriia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS2_k127_2315129_0	1340493.JNIF01000003_gene3744	5.827e-207	654.0	COG1129@1|root,COG1129@2|Bacteria,3Y3UY@57723|Acidobacteria	57723|Acidobacteria	P	ABC transporter	-	-	3.6.3.17	ko:K10441,ko:K10545,ko:K10562	ko02010,map02010	M00212,M00215,M00220	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.4,3.A.1.2.9	-	-	ABC_tran
TLS2_k127_2315129_1	1340493.JNIF01000003_gene3743	2.424e-146	469.0	COG1172@1|root,COG1172@2|Bacteria,3Y5DG@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
TLS2_k127_2315129_2	1267535.KB906767_gene4238	1.225e-140	452.0	COG0329@1|root,COG0329@2|Bacteria,3Y6I2@57723|Acidobacteria,2JMAW@204432|Acidobacteriia	204432|Acidobacteriia	EM	Dihydrodipicolinate synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2315129_3	1267535.KB906767_gene4237	8.627e-131	425.0	COG0451@1|root,COG0451@2|Bacteria,3Y6G4@57723|Acidobacteria,2JM4D@204432|Acidobacteriia	204432|Acidobacteriia	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_2315129_4	234267.Acid_5266	5.046e-67	235.0	COG1839@1|root,COG1839@2|Bacteria,3Y7IR@57723|Acidobacteria	57723|Acidobacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
TLS2_k127_2315129_7	313603.FB2170_14168	0.0009701	50.0	28NAV@1|root,2ZBEH@2|Bacteria,4NJGP@976|Bacteroidetes,1I0G3@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2315129_6	1267535.KB906767_gene2488	0.0004026	45.0	COG0557@1|root,COG0557@2|Bacteria,3Y3TF@57723|Acidobacteria,2JIM3@204432|Acidobacteriia	204432|Acidobacteriia	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
TLS2_k127_2315187_1	234267.Acid_0773	6.112e-89	297.0	COG1011@1|root,COG1011@2|Bacteria,3Y4BM@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
TLS2_k127_2315187_2	35754.JNYJ01000025_gene8853	6.085e-31	139.0	COG0790@1|root,COG0790@2|Bacteria,2GKCE@201174|Actinobacteria,4DE58@85008|Micromonosporales	201174|Actinobacteria	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1,TPR_10,TPR_16,TPR_4
TLS2_k127_2315187_0	234267.Acid_0772	7.074e-271	849.0	COG0308@1|root,COG0457@1|root,COG0308@2|Bacteria,COG0457@2|Bacteria,3Y3C5@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1,TPR_11,TPR_16
TLS2_k127_2315187_4	1340493.JNIF01000003_gene2584	2.358e-11	67.0	COG0763@1|root,COG0763@2|Bacteria,3Y34H@57723|Acidobacteria	57723|Acidobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
TLS2_k127_2315187_3	1123053.AUDG01000038_gene351	6.149e-15	79.0	COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,1S6WD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein	dsbB	GO:0003674,GO:0003824,GO:0006091,GO:0006457,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0022900,GO:0044237,GO:0050896,GO:0055114	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	iAF1260.b1185,iB21_1397.B21_01170,iBWG_1329.BWG_1010,iEC042_1314.EC042_1234,iEC55989_1330.EC55989_1280,iECBD_1354.ECBD_2437,iECB_1328.ECB_01160,iECDH10B_1368.ECDH10B_1238,iECDH1ME8569_1439.ECDH1ME8569_1124,iECD_1391.ECD_01160,iECED1_1282.ECED1_1327,iECIAI1_1343.ECIAI1_1202,iECO103_1326.ECO103_1287,iECSP_1301.ECSP_1582,iECUMN_1333.ECUMN_1474,iECs_1301.ECs1680,iETEC_1333.ETEC_1289,iEcDH1_1363.EcDH1_2463,iEcHS_1320.EcHS_A1288,iEcSMS35_1347.EcSMS35_1964,iEcolC_1368.EcolC_2440,iG2583_1286.G2583_1446,iJO1366.b1185,iSDY_1059.SDY_1222,iY75_1357.Y75_RS06185	DsbB
TLS2_k127_2316005_1	1123277.KB893217_gene4638	1.247e-39	148.0	COG2160@1|root,COG2160@2|Bacteria,4PPX9@976|Bacteroidetes,47YSK@768503|Cytophagia	976|Bacteroidetes	G	L-fucose isomerase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_Isome,Fucose_iso_C
TLS2_k127_2316005_0	1123277.KB893217_gene4642	2.98e-121	417.0	COG3250@1|root,COG3250@2|Bacteria,4NFE8@976|Bacteroidetes,47MPU@768503|Cytophagia	976|Bacteroidetes	G	glycoside hydrolase family 2 sugar binding	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
TLS2_k127_2328628_2	234267.Acid_2122	2.118e-50	182.0	COG0524@1|root,COG0524@2|Bacteria,3Y6VV@57723|Acidobacteria	57723|Acidobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
TLS2_k127_2328628_3	234267.Acid_7268	1.275e-26	113.0	COG1254@1|root,COG1254@2|Bacteria,3Y55N@57723|Acidobacteria	57723|Acidobacteria	C	acylphosphatase activity	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
TLS2_k127_2328628_1	234267.Acid_5899	2.507e-110	378.0	COG0515@1|root,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria	57723|Acidobacteria	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
TLS2_k127_2328628_0	1267535.KB906767_gene4183	2.798e-153	490.0	COG0552@1|root,COG0552@2|Bacteria,3Y3JQ@57723|Acidobacteria,2JIXJ@204432|Acidobacteriia	204432|Acidobacteriia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
TLS2_k127_2335697_1	234267.Acid_0540	2.344e-68	240.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
TLS2_k127_2335697_0	1267535.KB906767_gene1481	4.906e-76	268.0	COG1028@1|root,COG1028@2|Bacteria	1267535.KB906767_gene1481|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2335697_2	234267.Acid_1442	4.162e-23	105.0	COG0642@1|root,COG2205@2|Bacteria	234267.Acid_1442|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2336790_2	1304880.JAGB01000001_gene510	2.145e-14	76.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia	186801|Clostridia	G	Psort location Cytoplasmic, score 8.87	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS2_k127_2336790_1	234267.Acid_0330	1.109e-25	122.0	COG1345@1|root,COG1345@2|Bacteria,3Y84M@57723|Acidobacteria	57723|Acidobacteria	N	Flagellar hook-associated protein 2 N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	FliD_C,FliD_N
TLS2_k127_2336790_0	234267.Acid_0329	3.764e-51	200.0	COG1344@1|root,COG1344@2|Bacteria,3Y4AW@57723|Acidobacteria	57723|Acidobacteria	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	-	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
TLS2_k127_2336790_3	1121929.KB898663_gene979	0.0004035	45.0	COG1699@1|root,COG1699@2|Bacteria,1VA6Y@1239|Firmicutes,4HKYD@91061|Bacilli,470WJ@74385|Gracilibacillus	91061|Bacilli	S	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum	fliW	-	-	ko:K13626	-	-	-	-	ko00000,ko02035	-	-	-	FliW
TLS2_k127_2338206_12	234267.Acid_5909	4.291e-71	246.0	COG0483@1|root,COG0483@2|Bacteria,3Y3GD@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS2_k127_2338206_22	204669.Acid345_2059	9.668e-16	79.0	COG1923@1|root,COG1923@2|Bacteria,3Y5PK@57723|Acidobacteria,2JJYT@204432|Acidobacteriia	204432|Acidobacteriia	S	Hfq protein	-	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
TLS2_k127_2338206_11	1267535.KB906767_gene673	4.104e-74	261.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria,2JIRN@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
TLS2_k127_2338206_8	1340493.JNIF01000003_gene4083	6.395e-90	303.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,3Y519@57723|Acidobacteria	57723|Acidobacteria	H	MoaE protein	-	-	2.8.1.12	ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
TLS2_k127_2338206_18	1267535.KB906767_gene671	1.343e-47	174.0	COG0824@1|root,COG0824@2|Bacteria,3Y4WZ@57723|Acidobacteria,2JJIE@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
TLS2_k127_2338206_1	1267535.KB906767_gene626	8.014e-157	497.0	COG0320@1|root,COG0320@2|Bacteria,3Y3D4@57723|Acidobacteria,2JI3W@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
TLS2_k127_2338206_6	1267535.KB906767_gene392	1.243e-100	341.0	COG3643@1|root,COG3643@2|Bacteria,3Y3HP@57723|Acidobacteria,2JIP9@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Formiminotransferase domain	-	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_N
TLS2_k127_2338206_9	234267.Acid_4089	1.274e-81	287.0	COG1228@1|root,COG1228@2|Bacteria,3Y3BK@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
TLS2_k127_2338206_17	234267.Acid_0315	1.228e-50	186.0	COG1514@1|root,COG1514@2|Bacteria,3Y5S7@57723|Acidobacteria	57723|Acidobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
TLS2_k127_2338206_15	1267535.KB906767_gene1335	2.312e-64	230.0	COG0344@1|root,COG0344@2|Bacteria,3Y51D@57723|Acidobacteria,2JJFC@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
TLS2_k127_2338206_4	1267535.KB906767_gene1336	7.884e-104	358.0	COG0240@1|root,COG0240@2|Bacteria,3Y3ZH@57723|Acidobacteria,2JINS@204432|Acidobacteriia	204432|Acidobacteriia	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
TLS2_k127_2338206_21	472759.Nhal_0282	9.147e-19	94.0	2AGA5@1|root,316FN@2|Bacteria,1NHJF@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2338206_23	240292.Ava_3292	2.27e-06	58.0	2E2HB@1|root,32XMA@2|Bacteria,1G8SX@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2338206_2	1267535.KB906767_gene748	1.698e-143	462.0	COG0462@1|root,COG0462@2|Bacteria,3Y3KV@57723|Acidobacteria,2JHTF@204432|Acidobacteriia	204432|Acidobacteriia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
TLS2_k127_2338206_10	1267535.KB906767_gene747	7.174e-77	263.0	COG1825@1|root,COG1825@2|Bacteria,3Y41C@57723|Acidobacteria,2JHW5@204432|Acidobacteriia	204432|Acidobacteriia	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
TLS2_k127_2338206_13	234267.Acid_7094	8.763e-68	235.0	COG0193@1|root,COG0193@2|Bacteria,3Y48V@57723|Acidobacteria	57723|Acidobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
TLS2_k127_2338206_20	1267535.KB906767_gene745	1.321e-45	169.0	COG0360@1|root,COG0360@2|Bacteria,3Y50N@57723|Acidobacteria	57723|Acidobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
TLS2_k127_2338206_19	1267535.KB906767_gene744	6.06e-47	169.0	COG0238@1|root,COG0238@2|Bacteria,3Y53K@57723|Acidobacteria	57723|Acidobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
TLS2_k127_2338206_16	234267.Acid_7091	2.28e-57	203.0	COG0359@1|root,COG0359@2|Bacteria,3Y4MD@57723|Acidobacteria	57723|Acidobacteria	J	binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
TLS2_k127_2338206_3	1123242.JH636438_gene5875	2.316e-110	372.0	COG1520@1|root,COG1520@2|Bacteria,2IYNF@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TLS2_k127_2338206_5	497964.CfE428DRAFT_5491	1.14e-101	338.0	COG0657@1|root,COG0657@2|Bacteria,46SVI@74201|Verrucomicrobia	74201|Verrucomicrobia	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS2_k127_2338206_0	1340493.JNIF01000003_gene4543	0.0	1202.0	COG0587@1|root,COG0587@2|Bacteria,3Y3YK@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the DNA polymerase type-C family. DnaE2 subfamily	-	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
TLS2_k127_2338206_7	644283.Micau_2181	1.237e-92	314.0	COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria,4DA3W@85008|Micromonosporales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_2338206_14	344747.PM8797T_02544	7.324e-66	228.0	COG1028@1|root,COG1028@2|Bacteria,2IX1Z@203682|Planctomycetes	203682|Planctomycetes	IQ	with different specificities (related to short-chain alcohol	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_234701_0	1267535.KB906767_gene2414	6.014e-242	754.0	COG0028@1|root,COG0028@2|Bacteria,3Y3GJ@57723|Acidobacteria,2JI90@204432|Acidobacteriia	204432|Acidobacteriia	EH	Acetolactate synthase, large subunit	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_2347400_5	69042.WH5701_02015	2.613e-10	61.0	COG1398@1|root,COG1398@2|Bacteria,1G100@1117|Cyanobacteria,1GYSI@1129|Synechococcus	1117|Cyanobacteria	I	desaturase	desC	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
TLS2_k127_2347400_1	1340493.JNIF01000003_gene2340	8.441e-69	240.0	COG1269@1|root,COG1269@2|Bacteria,3Y565@57723|Acidobacteria	57723|Acidobacteria	C	Protein of unknown function (DUF3485)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3485
TLS2_k127_2347400_0	234267.Acid_0454	3.373e-91	308.0	COG1269@1|root,COG1269@2|Bacteria,3Y62W@57723|Acidobacteria	57723|Acidobacteria	C	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
TLS2_k127_2347400_2	234267.Acid_1101	2.407e-68	240.0	COG0745@1|root,COG0745@2|Bacteria,3Y4D1@57723|Acidobacteria	57723|Acidobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_2347400_3	234267.Acid_1102	1.226e-59	216.0	COG0642@1|root,COG2205@2|Bacteria,3Y4AU@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_23542_1	1267535.KB906767_gene3994	2.052e-64	225.0	COG0755@1|root,COG0755@2|Bacteria,3Y4FE@57723|Acidobacteria,2JJ1X@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM Cytochrome c assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
TLS2_k127_23542_0	234267.Acid_4237	1.57e-88	297.0	COG2386@1|root,COG2386@2|Bacteria,3Y3G1@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Cytochrome c-type biogenesis protein CcmB	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
TLS2_k127_23542_2	1038859.AXAU01000016_gene6832	2.777e-16	80.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2TUQ1@28211|Alphaproteobacteria,3JRVC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_2364578_3	1267533.KB906737_gene1875	5.571e-51	191.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_2364578_2	234267.Acid_0302	2.394e-91	305.0	COG0602@1|root,COG0602@2|Bacteria,3Y2UA@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
TLS2_k127_2364578_1	1340493.JNIF01000004_gene551	1.007e-159	508.0	COG2304@1|root,COG2304@2|Bacteria,3Y6RY@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_2364578_0	234267.Acid_3731	0.0	1302.0	2EXAB@1|root,33QKZ@2|Bacteria,3Y6WS@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2377079_2	234267.Acid_4497	1.667e-109	385.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y44T@57723|Acidobacteria	57723|Acidobacteria	KLT	PFAM Protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,Trans_reg_C
TLS2_k127_2377079_16	87626.PTD2_04958	1.206e-05	47.0	2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2377079_4	1267535.KB906767_gene2934	1.594e-97	322.0	COG0717@1|root,COG0717@2|Bacteria,3Y42N@57723|Acidobacteria	57723|Acidobacteria	F	dUTPase	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
TLS2_k127_2377079_8	1267535.KB906767_gene2935	2.553e-69	237.0	COG0756@1|root,COG0756@2|Bacteria,3Y58S@57723|Acidobacteria	57723|Acidobacteria	F	dUTPase	-	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
TLS2_k127_2377079_0	234267.Acid_0415	4.102e-173	555.0	COG1351@1|root,COG1351@2|Bacteria,3Y3AY@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
TLS2_k127_2377079_11	1267535.KB906767_gene2937	9.126e-43	167.0	2FBCE@1|root,343I9@2|Bacteria,3Y8Q4@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2377079_7	1267535.KB906767_gene2938	4.35e-70	252.0	COG2304@1|root,COG2304@2|Bacteria,3Y483@57723|Acidobacteria,2JI1N@204432|Acidobacteriia	2|Bacteria	S	von Willebrand factor, type A	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	FHA,VWA,VWA_2
TLS2_k127_2377079_12	1267535.KB906767_gene2939	1.694e-42	165.0	COG3764@1|root,COG3764@2|Bacteria,3Y5NI@57723|Acidobacteria,2JNIT@204432|Acidobacteriia	204432|Acidobacteriia	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
TLS2_k127_2377079_5	1205680.CAKO01000029_gene5076	8.217e-96	322.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2U0HR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
TLS2_k127_2377079_10	395961.Cyan7425_0713	3.016e-46	170.0	COG2329@1|root,COG2329@2|Bacteria,1G8VM@1117|Cyanobacteria	1117|Cyanobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3291
TLS2_k127_2377079_1	1267535.KB906767_gene4672	6.47e-123	400.0	COG0825@1|root,COG0825@2|Bacteria,3Y34D@57723|Acidobacteria,2JHNW@204432|Acidobacteriia	204432|Acidobacteriia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
TLS2_k127_2377079_13	404589.Anae109_4070	3.238e-37	147.0	COG2032@1|root,COG2032@2|Bacteria,1RGV4@1224|Proteobacteria	1224|Proteobacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodC	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005507,GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044421,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	iEcolC_1368.EcolC_1983	Sod_Cu
TLS2_k127_2377079_6	426117.M446_5012	4.268e-73	273.0	COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2TR6Z@28211|Alphaproteobacteria,1JRHF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat protein	MA20_34510	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
TLS2_k127_2377079_3	234267.Acid_6905	8.809e-99	350.0	COG3336@1|root,COG3336@2|Bacteria,3Y6N7@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	-	-	-	-	-	-	-	-	-	Caa3_CtaG
TLS2_k127_2377079_9	265072.Mfla_1447	3.078e-55	199.0	COG1845@1|root,COG1845@2|Bacteria,1RG95@1224|Proteobacteria,2VS0Y@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c oxidase subunit III	-	-	-	-	-	-	-	-	-	-	-	-	COX3
TLS2_k127_2395732_1	234267.Acid_1547	3.271e-26	113.0	COG0745@1|root,COG0745@2|Bacteria	234267.Acid_1547|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2395732_0	1267535.KB906767_gene5299	3.629e-109	366.0	COG1073@1|root,COG3250@1|root,COG1073@2|Bacteria,COG3250@2|Bacteria,3Y652@57723|Acidobacteria	57723|Acidobacteria	G	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2395757_6	1267533.KB906738_gene2027	4.536e-11	63.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_2395757_2	234267.Acid_4752	1.859e-84	291.0	COG4974@1|root,COG4974@2|Bacteria,3Y68K@57723|Acidobacteria	57723|Acidobacteria	L	phage integrase domain protein SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
TLS2_k127_2395757_1	234267.Acid_3308	3.573e-85	287.0	COG0517@1|root,COG0517@2|Bacteria,3Y6WE@57723|Acidobacteria	57723|Acidobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
TLS2_k127_2395757_4	1354722.JQLS01000004_gene4276	1.666e-43	168.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,46RM8@74030|Roseovarius	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
TLS2_k127_2395757_7	1123399.AQVE01000001_gene562	1.543e-09	62.0	COG4634@1|root,COG4634@2|Bacteria,1N9QC@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mut7-C
TLS2_k127_2395757_5	713587.THITH_03715	1.099e-25	108.0	COG2442@1|root,COG2442@2|Bacteria,1N96I@1224|Proteobacteria,1SHY0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
TLS2_k127_2395757_0	234267.Acid_0434	0.0	1344.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	choD	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,FAD_oxidored,GMC_oxred_C,GMC_oxred_N
TLS2_k127_2395757_3	886293.Sinac_0744	3.539e-54	194.0	COG3119@1|root,COG3119@2|Bacteria,2IXUN@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_2398861_5	269799.Gmet_2656	6.496e-10	64.0	2EG51@1|root,339WY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2398861_0	861299.J421_3108	1.918e-49	188.0	2F044@1|root,33T7T@2|Bacteria,1ZTDC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2398861_6	248742.XP_005644166.1	2.135e-05	54.0	2BGJX@1|root,2S19K@2759|Eukaryota,380MM@33090|Viridiplantae,34MA7@3041|Chlorophyta	3041|Chlorophyta	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
TLS2_k127_2398861_3	1121378.KB899724_gene60	1.828e-21	100.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_2398861_2	761193.Runsl_0677	1.289e-33	136.0	COG0537@1|root,COG0537@2|Bacteria,4NQ4X@976|Bacteroidetes,47Q95@768503|Cytophagia	976|Bacteroidetes	FG	HIT family hydrolase	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
TLS2_k127_2398861_1	365528.KB891170_gene5124	3.439e-45	173.0	COG2227@1|root,COG2227@2|Bacteria,2GM1S@201174|Actinobacteria	201174|Actinobacteria	H	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_2398861_4	926569.ANT_21410	1.576e-14	74.0	COG2944@1|root,COG2944@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,HTH_31
TLS2_k127_2402118_0	309807.SRU_2034	1.105e-221	707.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,1FJXZ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	EU	Prolyl oligopeptidase family	-	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
TLS2_k127_2402118_2	234267.Acid_1508	4.392e-126	415.0	COG2421@1|root,COG2421@2|Bacteria	2|Bacteria	C	formamidase activity	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
TLS2_k127_2402118_1	525904.Tter_2214	1.72e-180	572.0	COG4948@1|root,COG4948@2|Bacteria,2NR3V@2323|unclassified Bacteria	2|Bacteria	M	Mandelate racemase / muconate lactonizing enzyme, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_2402118_4	1408254.T458_19885	7.496e-70	245.0	COG1402@1|root,COG1402@2|Bacteria,1V0N8@1239|Firmicutes,4HK2P@91061|Bacilli,276QJ@186822|Paenibacillaceae	91061|Bacilli	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
TLS2_k127_2402118_3	1144319.PMI16_04103	5.542e-100	342.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,472JW@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	argininosuccinate lyase	-	-	-	-	-	-	-	-	-	-	-	-	ASL_C2,Lyase_1
TLS2_k127_2402283_3	240015.ACP_3141	9.909e-09	60.0	COG1629@1|root,COG4771@2|Bacteria,3Y3Y0@57723|Acidobacteria,2JIYU@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_2402283_0	1123242.JH636434_gene3694	2.61e-287	917.0	COG2010@1|root,COG2010@2|Bacteria,2IYF6@203682|Planctomycetes	203682|Planctomycetes	C	Protein of unknown function (DUF1549)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_2402283_1	1123242.JH636434_gene3693	1.3e-179	573.0	COG4102@1|root,COG4102@2|Bacteria,2IYN9@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_2402283_2	641524.ADICYQ_5692	1.249e-67	240.0	COG3119@1|root,COG3119@2|Bacteria,4NE7S@976|Bacteroidetes	976|Bacteroidetes	P	COG COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_2405374_4	1267535.KB906767_gene3728	1.658e-176	574.0	COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria,2JJYF@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS2_k127_2405374_8	1267535.KB906767_gene3727	4.121e-15	82.0	COG2930@1|root,COG2930@2|Bacteria,3Y6Q0@57723|Acidobacteria	57723|Acidobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
TLS2_k127_2405374_7	1340493.JNIF01000004_gene30	1.95e-92	316.0	COG4251@1|root,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
TLS2_k127_2405374_2	1267535.KB906767_gene3725	3.745e-271	844.0	COG3829@1|root,COG3829@2|Bacteria,3Y2V9@57723|Acidobacteria	57723|Acidobacteria	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HTH_8,PAS_9,Sigma54_activat
TLS2_k127_2405374_1	1267535.KB906767_gene3729	9.726e-289	899.0	COG0281@1|root,COG0281@2|Bacteria,3Y43V@57723|Acidobacteria	57723|Acidobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
TLS2_k127_2405374_9	204669.Acid345_2695	9.259e-08	56.0	2C7DG@1|root,2ZTXV@2|Bacteria,3Y94Z@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2405374_0	1267535.KB906767_gene3736	0.0	1300.0	COG0438@1|root,COG0438@2|Bacteria,3Y68X@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_2405374_3	1267535.KB906767_gene3737	1.105e-224	706.0	COG2152@1|root,COG2152@2|Bacteria,3Y740@57723|Acidobacteria	57723|Acidobacteria	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
TLS2_k127_2405374_5	1267535.KB906767_gene3738	1.88e-169	537.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	ko:K00713,ko:K06338	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_2405374_6	1340493.JNIF01000003_gene2575	3.955e-97	331.0	COG1629@1|root,COG1629@2|Bacteria,3Y3KT@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_2409837_4	469383.Cwoe_3783	1.026e-45	171.0	COG2411@1|root,COG2411@2|Bacteria,2HRSA@201174|Actinobacteria,4CTVC@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2409837_3	234267.Acid_3467	2.434e-55	202.0	2F4XC@1|root,33XJD@2|Bacteria,3Y7TM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2409837_0	234267.Acid_7933	6.391e-82	279.0	COG0175@1|root,COG0529@1|root,COG0175@2|Bacteria,COG0529@2|Bacteria,3Y5BG@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the synthesis of activated sulfate	cysC	-	1.8.4.10,1.8.4.8,2.7.1.25	ko:K00390,ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R02021,R04928	RC00002,RC00007,RC00078,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
TLS2_k127_2409837_1	234267.Acid_7933	1.291e-81	274.0	COG0175@1|root,COG0529@1|root,COG0175@2|Bacteria,COG0529@2|Bacteria,3Y5BG@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the synthesis of activated sulfate	cysC	-	1.8.4.10,1.8.4.8,2.7.1.25	ko:K00390,ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R02021,R04928	RC00002,RC00007,RC00078,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
TLS2_k127_2409837_2	234267.Acid_7932	4.214e-64	226.0	COG0613@1|root,COG0613@2|Bacteria,3Y5C1@57723|Acidobacteria	57723|Acidobacteria	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
TLS2_k127_24207_0	1340493.JNIF01000004_gene155	1.273e-163	539.0	COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	CARDB,Calx-beta,CarboxypepD_reg,He_PIG,Laminin_G_3,NHL,SGL
TLS2_k127_24207_1	1340493.JNIF01000004_gene759	8.896e-123	399.0	COG0667@1|root,COG0667@2|Bacteria,3Y6M9@57723|Acidobacteria	57723|Acidobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_24207_2	1340493.JNIF01000004_gene762	2.728e-49	187.0	COG1879@1|root,COG1879@2|Bacteria,3Y872@57723|Acidobacteria	57723|Acidobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TLS2_k127_2434229_0	1340493.JNIF01000003_gene3917	1.229e-76	264.0	COG1624@1|root,COG1624@2|Bacteria,3Y7NU@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	-	-	-	-	-	-	-	-	-	-	DisA_N
TLS2_k127_2434229_2	234267.Acid_3520	1.85e-45	181.0	COG1595@1|root,COG1595@2|Bacteria,3Y5BF@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2434229_4	204669.Acid345_4398	1.054e-06	56.0	2ERSC@1|root,33JBJ@2|Bacteria,3Y5XV@57723|Acidobacteria,2JK5S@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2434229_3	1267535.KB906767_gene3332	2.288e-37	147.0	2DKN8@1|root,32UFB@2|Bacteria,3Y55I@57723|Acidobacteria,2JJU7@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4252
TLS2_k127_2434229_1	401053.AciPR4_0872	1.641e-56	199.0	COG1077@1|root,COG1077@2|Bacteria,3Y3VC@57723|Acidobacteria,2JHQ2@204432|Acidobacteriia	204432|Acidobacteriia	D	cell shape determining protein MreB	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TLS2_k127_2446582_6	1340493.JNIF01000003_gene2458	3.776e-18	89.0	2EKYQ@1|root,33EN7@2|Bacteria,3Y5T5@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2446582_2	1340493.JNIF01000003_gene2459	2.451e-104	348.0	COG2304@1|root,COG2304@2|Bacteria,3Y483@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_2446582_1	1340493.JNIF01000003_gene2460	2.124e-144	465.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
TLS2_k127_2446582_4	234267.Acid_6216	1.319e-90	321.0	COG1212@1|root,COG1212@2|Bacteria,3Y4GZ@57723|Acidobacteria	57723|Acidobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
TLS2_k127_2446582_0	1267535.KB906767_gene621	6.007e-294	911.0	COG0504@1|root,COG0504@2|Bacteria,3Y2MH@57723|Acidobacteria,2JID4@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
TLS2_k127_2446582_3	1340493.JNIF01000003_gene1496	7.638e-100	335.0	COG2877@1|root,COG2877@2|Bacteria,3Y2WF@57723|Acidobacteria	57723|Acidobacteria	M	PFAM DAHP synthetase I	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
TLS2_k127_2446582_5	234267.Acid_5399	2.223e-18	93.0	2E1AY@1|root,32WQW@2|Bacteria,3Y8WG@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2447526_7	234267.Acid_4014	2.334e-29	124.0	COG0673@1|root,COG0673@2|Bacteria,3Y4KS@57723|Acidobacteria	2|Bacteria	S	PFAM oxidoreductase domain protein	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_2447526_2	234267.Acid_6309	2.477e-112	369.0	COG1091@1|root,COG1091@2|Bacteria,3Y3IG@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
TLS2_k127_2447526_3	234267.Acid_6308	6.095e-111	367.0	COG2304@1|root,COG2304@2|Bacteria,3Y2PC@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_2447526_6	234267.Acid_6307	2.007e-73	254.0	COG0122@1|root,COG0122@2|Bacteria,3Y7N6@57723|Acidobacteria	57723|Acidobacteria	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TLS2_k127_2447526_0	234267.Acid_7336	5.926e-251	782.0	COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria	57723|Acidobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS2_k127_2447526_4	1411123.JQNH01000001_gene1302	8.069e-88	308.0	COG0500@1|root,COG4797@1|root,COG0500@2|Bacteria,COG4797@2|Bacteria,1MX2X@1224|Proteobacteria,2TSMI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	MethyTransf_Reg,Methyltransf_12,Methyltransf_25,Methyltransf_31
TLS2_k127_2447526_1	234267.Acid_1559	2.384e-206	649.0	COG0498@1|root,COG0498@2|Bacteria,3Y3G4@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_2447526_5	404589.Anae109_2667	5.391e-76	259.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,42P5X@68525|delta/epsilon subdivisions,2WIQW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS2_k127_2451205_2	937777.Deipe_1807	4.388e-71	267.0	COG4251@1|root,COG5000@1|root,COG4251@2|Bacteria,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
TLS2_k127_2451205_4	32024.JMTI01000008_gene1227	0.0001734	48.0	2A4CB@1|root,30SXZ@2|Bacteria,1PCGS@1224|Proteobacteria,42W82@68525|delta/epsilon subdivisions,2YQMV@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2451205_0	268407.PWYN_04975	4.378e-122	398.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,4HASY@91061|Bacilli,26TNV@186822|Paenibacillaceae	91061|Bacilli	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_2451205_1	234267.Acid_4531	8.993e-76	261.0	COG1387@1|root,COG1387@2|Bacteria,3Y6GG@57723|Acidobacteria	57723|Acidobacteria	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_2451205_3	1340493.JNIF01000003_gene2702	3.45e-47	172.0	COG3910@1|root,COG3910@2|Bacteria,3Y5FF@57723|Acidobacteria	57723|Acidobacteria	S	SMART AAA ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21,AAA_23
TLS2_k127_2458981_1	378806.STAUR_4422	5.501e-152	494.0	COG3507@1|root,COG3507@2|Bacteria,1MWY2@1224|Proteobacteria,4391R@68525|delta/epsilon subdivisions,2X479@28221|Deltaproteobacteria,2YYED@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
TLS2_k127_2458981_0	1340493.JNIF01000004_gene1066	4.459e-189	611.0	COG1473@1|root,COG1473@2|Bacteria	2|Bacteria	S	N-acetyldiaminopimelate deacetylase activity	-	-	-	ko:K12941	-	-	-	-	ko00000,ko01002	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_2458981_2	1185876.BN8_00270	2.522e-08	59.0	COG3622@1|root,COG3622@2|Bacteria,4NG74@976|Bacteroidetes,47K7Z@768503|Cytophagia	976|Bacteroidetes	G	PFAM Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_2459168_8	1340493.JNIF01000004_gene777	9.181e-99	330.0	COG4654@1|root,COG4654@2|Bacteria	2|Bacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PSCyt1,PSCyt2,PSD1
TLS2_k127_2459168_2	1340493.JNIF01000004_gene776	6.745e-196	620.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_2459168_7	349163.Acry_1069	7.924e-109	363.0	COG0287@1|root,COG0287@2|Bacteria,1QN63@1224|Proteobacteria,2TT5P@28211|Alphaproteobacteria,2JVN1@204441|Rhodospirillales	204441|Rhodospirillales	E	Phosphogluconate dehydrogenase (decarboxylating) C-term	-	-	-	-	-	-	-	-	-	-	-	-	PGDH_C
TLS2_k127_2459168_4	525904.Tter_2007	1.35e-163	539.0	2CB42@1|root,2Z7Y3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2459168_1	234267.Acid_3496	2.553e-213	676.0	COG0457@1|root,COG0457@2|Bacteria,3Y3WM@57723|Acidobacteria	57723|Acidobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS2_k127_2459168_10	234267.Acid_3494	4.024e-34	146.0	COG0457@1|root,COG0457@2|Bacteria,3Y6B2@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
TLS2_k127_2459168_0	1340493.JNIF01000004_gene88	0.0	1034.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_2459168_12	1121403.AUCV01000032_gene2903	1.173e-05	56.0	COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,42NZK@68525|delta/epsilon subdivisions,2WIY5@28221|Deltaproteobacteria,2MJAV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8,zinc_ribbon_4
TLS2_k127_2459168_9	670292.JH26_08290	4.489e-71	249.0	COG2186@1|root,COG2186@2|Bacteria,1N6N0@1224|Proteobacteria,2U94Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	FCD	-	-	-	ko:K22104	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
TLS2_k127_2459168_3	639283.Snov_3661	7.924e-177	564.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2TSJV@28211|Alphaproteobacteria,3EZ4T@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Ribulose bisphosphate carboxylase large chain, N-terminal domain	-	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
TLS2_k127_2459168_6	1125973.JNLC01000010_gene1869	9.258e-130	431.0	COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,2TS85@28211|Alphaproteobacteria,3JXET@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative sugar-binding N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1357_C,DUF1537
TLS2_k127_2459168_5	1340493.JNIF01000003_gene1948	1.032e-133	435.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_2459168_11	1340493.JNIF01000003_gene1949	1.142e-24	107.0	COG0526@1|root,COG0526@2|Bacteria,3Y64J@57723|Acidobacteria	57723|Acidobacteria	CO	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_24617_1	1267535.KB906767_gene5094	2.051e-52	194.0	COG1215@1|root,COG1215@2|Bacteria,3Y3J4@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS2_k127_24617_0	1340493.JNIF01000004_gene825	1.876e-98	329.0	COG0405@1|root,COG0405@2|Bacteria,3Y6KV@57723|Acidobacteria	57723|Acidobacteria	M	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_2469328_9	234267.Acid_7049	6.119e-10	60.0	COG1451@1|root,COG1451@2|Bacteria,3Y2SM@57723|Acidobacteria	57723|Acidobacteria	S	nucleotide metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2469328_8	755178.Cyan10605_0305	2.602e-28	119.0	COG2703@1|root,COG2703@2|Bacteria,1G8KU@1117|Cyanobacteria	1117|Cyanobacteria	P	PFAM Hemerythrin HHE cation binding domain	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
TLS2_k127_2469328_3	234267.Acid_7895	5.222e-126	429.0	28MCK@1|root,2ZAQP@2|Bacteria,3Y41I@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2469328_5	234267.Acid_7896	3.142e-112	373.0	COG3005@1|root,COG3005@2|Bacteria,3Y4BJ@57723|Acidobacteria	57723|Acidobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
TLS2_k127_2469328_1	234267.Acid_7897	1.707e-200	646.0	COG3303@1|root,COG3303@2|Bacteria,3Y84F@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2469328_7	234267.Acid_1042	1.887e-44	162.0	COG1146@1|root,COG1146@2|Bacteria,3Y59N@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4
TLS2_k127_2469328_2	234267.Acid_1490	2.81e-192	619.0	COG3276@1|root,COG3276@2|Bacteria,3Y6R2@57723|Acidobacteria	57723|Acidobacteria	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
TLS2_k127_2469328_6	1267535.KB906767_gene3135	2.144e-60	230.0	COG2304@1|root,COG2304@2|Bacteria,3Y8A4@57723|Acidobacteria	57723|Acidobacteria	S	VWA domain containing CoxE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
TLS2_k127_2469328_0	234267.Acid_1492	1.289e-265	826.0	COG4799@1|root,COG4799@2|Bacteria,3Y3SM@57723|Acidobacteria	57723|Acidobacteria	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_2469328_4	886293.Sinac_4418	7.04e-124	416.0	COG5434@1|root,COG5434@2|Bacteria,2J4KC@203682|Planctomycetes	203682|Planctomycetes	M	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2476010_0	234267.Acid_6875	1.309e-202	661.0	COG3485@1|root,COG3485@2|Bacteria,3Y3FU@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_2477827_7	1267535.KB906767_gene711	5.045e-88	306.0	COG4932@1|root,COG4932@2|Bacteria,3Y6EM@57723|Acidobacteria,2JKUS@204432|Acidobacteriia	57723|Acidobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_2477827_4	886293.Sinac_7086	2.359e-173	580.0	COG0330@1|root,COG2217@1|root,COG0330@2|Bacteria,COG2217@2|Bacteria,2IWRY@203682|Planctomycetes	203682|Planctomycetes	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.3,3.6.3.5,3.6.3.54	ko:K01534,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5,3.A.3.6	-	-	Band_7,E1-E2_ATPase,Hydrolase
TLS2_k127_2477827_9	1487923.DP73_10970	1.675e-68	244.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia	186801|Clostridia	O	SPFH Band 7 PHB domain protein	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
TLS2_k127_2477827_12	1121434.AULY01000007_gene1256	1.234e-53	201.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,42NUT@68525|delta/epsilon subdivisions,2WKQX@28221|Deltaproteobacteria,2M80N@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
TLS2_k127_2477827_14	641524.ADICYQ_0005	1.263e-45	176.0	COG3204@1|root,COG3204@2|Bacteria,4NNX0@976|Bacteroidetes,47P1B@768503|Cytophagia	976|Bacteroidetes	L	pilus organization	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2477827_1	234267.Acid_6208	4.316e-219	692.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,3Y4F0@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome b(C-terminal)/b6/petD	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C,Cytochrome_B
TLS2_k127_2477827_13	234267.Acid_6209	1.27e-52	192.0	COG0723@1|root,COG0723@2|Bacteria,3Y7YJ@57723|Acidobacteria	57723|Acidobacteria	C	Rieske [2Fe-2S] domain	-	-	-	ko:K03886	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
TLS2_k127_2477827_0	234267.Acid_7188	3.558e-257	816.0	COG2844@1|root,COG2844@2|Bacteria,3Y2FJ@57723|Acidobacteria	57723|Acidobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	DUF294,GlnD_UR_UTase,HD
TLS2_k127_2477827_10	234267.Acid_7189	7.312e-56	196.0	COG0347@1|root,COG0347@2|Bacteria,3Y4TF@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
TLS2_k127_2477827_2	1267535.KB906767_gene640	5.164e-209	658.0	COG0004@1|root,COG0004@2|Bacteria,3Y2VR@57723|Acidobacteria,2JHMR@204432|Acidobacteriia	204432|Acidobacteriia	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TLS2_k127_2477827_6	1340493.JNIF01000003_gene2881	7.151e-117	386.0	COG2067@1|root,COG2067@2|Bacteria,3Y3JJ@57723|Acidobacteria	57723|Acidobacteria	I	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
TLS2_k127_2477827_3	497964.CfE428DRAFT_1132	4.898e-202	639.0	COG3303@1|root,COG3303@2|Bacteria,46UP1@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552
TLS2_k127_2477827_11	1184607.AUCHE_17_00250	1.101e-55	198.0	COG3005@1|root,COG3005@2|Bacteria,2IQTS@201174|Actinobacteria,4F70Y@85018|Dermatophilaceae	201174|Actinobacteria	C	NapC/NirT cytochrome c family, N-terminal region	nrfH	-	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT
TLS2_k127_2477827_8	204669.Acid345_3039	1.664e-86	296.0	28NTH@1|root,2ZBS4@2|Bacteria,3Y3NN@57723|Acidobacteria,2JIEU@204432|Acidobacteriia	204432|Acidobacteriia	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TLS2_k127_2483439_1	234267.Acid_2122	4.77e-162	515.0	COG0524@1|root,COG0524@2|Bacteria,3Y6VV@57723|Acidobacteria	57723|Acidobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
TLS2_k127_2483439_2	1248916.ANFY01000005_gene2673	4.659e-26	115.0	2BIWW@1|root,32D51@2|Bacteria,1PWXR@1224|Proteobacteria,2V12A@28211|Alphaproteobacteria,2KB24@204457|Sphingomonadales	204457|Sphingomonadales	S	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,VPEP
TLS2_k127_2483439_3	596151.DesfrDRAFT_4063	2.634e-19	96.0	COG0664@1|root,COG0664@2|Bacteria,1MZZD@1224|Proteobacteria,42QUX@68525|delta/epsilon subdivisions,2WMWV@28221|Deltaproteobacteria,2MB9P@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	PFAM Cyclic nucleotide-binding	fnr-1	-	-	ko:K01420,ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_2483439_0	443143.GM18_0341	2.353e-263	820.0	COG2133@1|root,COG2133@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2499765_1	1123242.JH636436_gene641	4.353e-127	420.0	COG3119@1|root,COG3119@2|Bacteria,2IX0S@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_2499765_2	322710.Avin_33880	2.757e-77	263.0	COG4297@1|root,COG4297@2|Bacteria,1RB1W@1224|Proteobacteria,1S6KS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein containing double-stranded beta helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2499765_0	234267.Acid_0546	1.074e-156	499.0	COG0498@1|root,COG0498@2|Bacteria,3Y2GX@57723|Acidobacteria	57723|Acidobacteria	E	TIGRFAM Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_2507423_1	234267.Acid_5457	2.469e-242	751.0	COG0085@1|root,COG0085@2|Bacteria,3Y36G@57723|Acidobacteria	57723|Acidobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
TLS2_k127_2507423_0	234267.Acid_5456	0.0	2544.0	COG0086@1|root,COG0086@2|Bacteria,3Y2FZ@57723|Acidobacteria	57723|Acidobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
TLS2_k127_2507423_2	697281.Mahau_2725	6.024e-44	166.0	COG0407@1|root,COG0407@2|Bacteria,1TR8Q@1239|Firmicutes,24B2U@186801|Clostridia,42IQ4@68295|Thermoanaerobacterales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	2.1.1.246,4.1.1.37	ko:K01599,ko:K14080	ko00680,ko00860,ko01100,ko01110,ko01120,ko01200,map00680,map00860,map01100,map01110,map01120,map01200	M00121,M00356	R03197,R04972,R09098,R10000	RC00035,RC00872,RC01144,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS2_k127_2507669_5	335543.Sfum_3543	3.318e-47	176.0	COG0596@1|root,COG0596@2|Bacteria,1QZ4I@1224|Proteobacteria,43CFI@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_2507669_0	502025.Hoch_6445	4.548e-213	673.0	COG3488@1|root,COG3488@2|Bacteria	2|Bacteria	C	Di-haem oxidoreductase, putative peroxidase	-	-	3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH30	-	DHOR
TLS2_k127_2507669_6	102129.Lepto7375DRAFT_7836	2.377e-14	80.0	2A53S@1|root,30TSD@2|Bacteria,1GGW0@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2507669_4	1340493.JNIF01000003_gene4036	1.327e-64	245.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2507669_2	1340493.JNIF01000003_gene1300	2.559e-124	411.0	COG1073@1|root,COG1073@2|Bacteria,3Y99D@57723|Acidobacteria	57723|Acidobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DUF2048
TLS2_k127_2507669_1	1267535.KB906767_gene5202	7.22e-176	568.0	COG0249@1|root,COG0249@2|Bacteria,3Y48T@57723|Acidobacteria,2JKU6@204432|Acidobacteriia	204432|Acidobacteriia	L	ATPase domain of DNA mismatch repair MUTS family	-	-	-	-	-	-	-	-	-	-	-	-	MutS_III,MutS_V
TLS2_k127_2507669_3	1340493.JNIF01000003_gene4181	8.317e-116	379.0	COG1879@1|root,COG1879@2|Bacteria,3Y872@57723|Acidobacteria	57723|Acidobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TLS2_k127_2509075_2	1267535.KB906767_gene3936	1.342e-31	128.0	COG1295@1|root,COG1295@2|Bacteria,3Y3AJ@57723|Acidobacteria,2JIPS@204432|Acidobacteriia	204432|Acidobacteriia	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_2509075_0	404589.Anae109_0232	5.788e-103	351.0	2DDTE@1|root,2ZJ6F@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2509075_1	309807.SRU_0977	8.318e-94	328.0	2AB2F@1|root,310G6@2|Bacteria,4PEZP@976|Bacteroidetes,1FJWS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2509075_3	504472.Slin_2814	2.015e-09	68.0	COG1409@1|root,COG4775@1|root,COG1409@2|Bacteria,COG4775@2|Bacteria,4NF9N@976|Bacteroidetes,47JAP@768503|Cytophagia	976|Bacteroidetes	M	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,Metallophos
TLS2_k127_2510347_1	234267.Acid_6488	1.419e-71	256.0	COG1629@1|root,COG4771@2|Bacteria,3Y7F9@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_2510347_2	247634.GPB2148_3390	1.483e-57	219.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_2510347_3	751945.Theos_0257	1.454e-11	72.0	COG1057@1|root,COG1057@2|Bacteria,1WJ70@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_2510347_0	1340493.JNIF01000003_gene4688	4.364e-84	280.0	COG0568@1|root,COG0568@2|Bacteria,3Y2XG@57723|Acidobacteria	57723|Acidobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_2511318_7	1121430.JMLG01000022_gene2433	3.34e-38	155.0	COG0845@1|root,COG0845@2|Bacteria,1V2JZ@1239|Firmicutes,24A5A@186801|Clostridia,261XD@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23,OEP
TLS2_k127_2511318_1	765913.ThidrDRAFT_4467	1.318e-268	860.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WXV4@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
TLS2_k127_2511318_9	234267.Acid_5312	2.823e-27	114.0	COG3369@1|root,COG3369@2|Bacteria,3Y5KG@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Iron sulphur-containing domain, CDGSH-type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
TLS2_k127_2511318_3	1267535.KB906767_gene2982	2.187e-186	587.0	COG4225@1|root,COG4225@2|Bacteria	2|Bacteria	S	unsaturated chondroitin disaccharide hydrolase activity	-	-	3.2.1.180	ko:K18581	-	-	R10867	RC00049,RC02427	ko00000,ko01000	-	GH88	-	Glyco_hydro_88
TLS2_k127_2511318_4	1267535.KB906767_gene2721	2.263e-154	493.0	COG0473@1|root,COG0473@2|Bacteria,3Y2VW@57723|Acidobacteria,2JIUD@204432|Acidobacteriia	204432|Acidobacteriia	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_2511318_11	234267.Acid_5073	1.925e-21	96.0	COG1918@1|root,COG1918@2|Bacteria,3Y92B@57723|Acidobacteria	57723|Acidobacteria	P	FeoA	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
TLS2_k127_2511318_0	1267535.KB906767_gene1113	9.054e-274	854.0	COG0370@1|root,COG0370@2|Bacteria,3Y3CZ@57723|Acidobacteria,2JJQ0@204432|Acidobacteriia	204432|Acidobacteriia	P	Ferrous iron transport protein B	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
TLS2_k127_2511318_2	234267.Acid_5393	8.922e-190	602.0	COG2256@1|root,COG2256@2|Bacteria,3Y3F7@57723|Acidobacteria	57723|Acidobacteria	L	AAA ATPase	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
TLS2_k127_2511318_5	234267.Acid_5394	3.998e-81	282.0	COG0566@1|root,COG0566@2|Bacteria,3Y4GM@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS2_k127_2511318_10	234267.Acid_5395	6.242e-22	103.0	COG1434@1|root,COG1434@2|Bacteria,3Y4FT@57723|Acidobacteria	57723|Acidobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
TLS2_k127_254272_1	1267535.KB906767_gene2315	1.058e-176	571.0	COG0457@1|root,COG0457@2|Bacteria,3Y7F4@57723|Acidobacteria	57723|Acidobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS2_k127_254272_2	1267535.KB906767_gene5366	2.186e-164	557.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Dioxygenase_C,TonB_dep_Rec
TLS2_k127_254272_0	1340493.JNIF01000004_gene88	1.786e-219	711.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_2551064_4	1469245.JFBG01000086_gene1608	6.367e-70	245.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,1RN40@1236|Gammaproteobacteria,1X2WW@135613|Chromatiales	1236|Gammaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	yagR	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_2551064_2	867903.ThesuDRAFT_01030	8.255e-120	398.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,3WCUZ@538999|Clostridiales incertae sedis	186801|Clostridia	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_2551064_1	867903.ThesuDRAFT_01029	8.313e-135	449.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,3WCUZ@538999|Clostridiales incertae sedis	186801|Clostridia	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_2551064_0	1297569.MESS2_1020028	4.026e-165	532.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2U0ZH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DDE (Asp,Asp,Glu) domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
TLS2_k127_2551064_3	204669.Acid345_4155	3.005e-74	269.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria,2JIZ4@204432|Acidobacteriia	204432|Acidobacteriia	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_2558470_1	1267535.KB906767_gene604	2.937e-277	862.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3Y37Y@57723|Acidobacteria,2JI9E@204432|Acidobacteriia	204432|Acidobacteriia	E	Vitamin B12 dependent methionine synthase activation	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TLS2_k127_2558470_4	234267.Acid_0096	3.994e-105	368.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56,TonB_C
TLS2_k127_2558470_5	401053.AciPR4_0692	6.453e-32	129.0	COG3682@1|root,COG3682@2|Bacteria,3Y57R@57723|Acidobacteria,2JN3S@204432|Acidobacteriia	204432|Acidobacteriia	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
TLS2_k127_2558470_2	1047013.AQSP01000144_gene928	3.225e-191	617.0	COG3533@1|root,COG3533@2|Bacteria,2NNW0@2323|unclassified Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	F5_F8_type_C,Glyco_hydro_127
TLS2_k127_2558470_0	1340493.JNIF01000004_gene88	0.0	1136.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_2558470_3	1122918.KB907250_gene3615	1.111e-112	375.0	COG5297@1|root,COG5297@2|Bacteria,1UMTG@1239|Firmicutes,4ITZS@91061|Bacilli	91061|Bacilli	G	Protein of unknown function (DUF1593)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1593
TLS2_k127_2558470_6	1185876.BN8_06001	7.097e-23	102.0	COG2730@1|root,COG2730@2|Bacteria,4NF3J@976|Bacteroidetes,47M4E@768503|Cytophagia	976|Bacteroidetes	G	Putative collagen-binding domain of a collagenase	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038
TLS2_k127_2559815_4	234267.Acid_6700	1.023e-65	232.0	COG0266@1|root,COG0266@2|Bacteria,3Y39U@57723|Acidobacteria	57723|Acidobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_2559815_0	234267.Acid_4372	2.072e-195	615.0	COG0448@1|root,COG0448@2|Bacteria,3Y35M@57723|Acidobacteria	57723|Acidobacteria	G	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_2559815_3	234267.Acid_1522	5.668e-98	324.0	COG2041@1|root,COG2041@2|Bacteria,3Y85H@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
TLS2_k127_2559815_2	1267535.KB906767_gene3179	4.03e-119	391.0	COG2220@1|root,COG2220@2|Bacteria,3Y2TV@57723|Acidobacteria,2JHT8@204432|Acidobacteriia	204432|Acidobacteriia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_2559815_6	234267.Acid_0752	2.865e-36	143.0	COG0517@1|root,COG0517@2|Bacteria,3Y8IB@57723|Acidobacteria	57723|Acidobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_2559815_5	234267.Acid_5179	8.797e-50	184.0	COG0779@1|root,COG0779@2|Bacteria,3Y528@57723|Acidobacteria	57723|Acidobacteria	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
TLS2_k127_2559815_1	234267.Acid_5180	4.117e-192	614.0	COG0195@1|root,COG0195@2|Bacteria,3Y379@57723|Acidobacteria	57723|Acidobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
TLS2_k127_2559815_7	234267.Acid_5181	1.662e-27	123.0	COG0532@1|root,COG3266@1|root,COG0532@2|Bacteria,COG3266@2|Bacteria,3Y3UG@57723|Acidobacteria	57723|Acidobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
TLS2_k127_2577895_1	76114.ebB145	2.775e-20	93.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP-7	-	-	-	-	-	-	-	-	-	-	-	PP-binding
TLS2_k127_2577895_0	76114.ebA4323	1.826e-120	410.0	COG1696@1|root,COG1696@2|Bacteria	2|Bacteria	M	negative regulation of protein lipidation	algI	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
TLS2_k127_257900_2	653386.HMPREF0975_02485	5.506e-16	84.0	COG0745@1|root,COG0745@2|Bacteria,2H3IN@201174|Actinobacteria,4D4WZ@85005|Actinomycetales	201174|Actinobacteria	KT	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_257900_0	243090.RB11303	3.146e-105	358.0	COG3464@1|root,COG3464@2|Bacteria,2J105@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
TLS2_k127_257900_1	1255043.TVNIR_2295	3.024e-72	255.0	29CPA@1|root,2ZZMJ@2|Bacteria,1QWMK@1224|Proteobacteria,1T601@1236|Gammaproteobacteria,1X2WP@135613|Chromatiales	1224|Proteobacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
TLS2_k127_2592479_3	502025.Hoch_2991	3.137e-107	357.0	COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,42UN5@68525|delta/epsilon subdivisions,2WQU9@28221|Deltaproteobacteria,2YXHW@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
TLS2_k127_2592479_1	234267.Acid_0720	2.035e-118	394.0	COG2333@1|root,COG2333@2|Bacteria,3Y323@57723|Acidobacteria	2|Bacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_2592479_7	1340493.JNIF01000003_gene2739	8.985e-43	161.0	COG4818@1|root,COG4818@2|Bacteria,3Y8T8@57723|Acidobacteria	57723|Acidobacteria	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2592479_6	1123060.JONP01000048_gene2414	1.952e-52	192.0	COG1959@1|root,COG1959@2|Bacteria,1RGVW@1224|Proteobacteria,2UA5C@28211|Alphaproteobacteria,2JTMC@204441|Rhodospirillales	204441|Rhodospirillales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TLS2_k127_2592479_2	1211115.ALIQ01000228_gene1134	2.543e-116	383.0	COG0492@1|root,COG0492@2|Bacteria,1MVWS@1224|Proteobacteria,2TU6F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
TLS2_k127_2592479_5	1255043.TVNIR_0913	1.548e-77	275.0	COG4974@1|root,COG4974@2|Bacteria,1QUHS@1224|Proteobacteria,1S2C4@1236|Gammaproteobacteria,1X0IU@135613|Chromatiales	135613|Chromatiales	L	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_2592479_4	1117958.PE143B_0100130	6.166e-81	281.0	COG0582@1|root,COG0582@2|Bacteria,1NX90@1224|Proteobacteria,1SDT1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_2592479_0	234267.Acid_6799	9.676e-182	572.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_2592479_8	234267.Acid_0646	5.519e-41	151.0	COG1484@1|root,COG1484@2|Bacteria,3Y6NW@57723|Acidobacteria	57723|Acidobacteria	L	Bacterial dnaA  protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
TLS2_k127_2602292_3	1267535.KB906767_gene3338	1.027e-69	240.0	COG1446@1|root,COG1446@2|Bacteria,3Y2Y8@57723|Acidobacteria,2JIW3@204432|Acidobacteriia	204432|Acidobacteriia	E	Asparaginase	-	-	3.5.1.26	ko:K01444	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Asparaginase_2
TLS2_k127_2602292_2	1340493.JNIF01000003_gene3143	1.744e-77	267.0	2BWKA@1|root,32QZQ@2|Bacteria	2|Bacteria	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
TLS2_k127_2602292_1	234267.Acid_1807	5.72e-132	429.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Thioredoxin_7
TLS2_k127_2602292_0	234267.Acid_7329	3.185e-158	505.0	COG0535@1|root,COG0535@2|Bacteria,3Y2KT@57723|Acidobacteria	57723|Acidobacteria	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
TLS2_k127_2606962_6	1340493.JNIF01000003_gene4238	3.108e-70	247.0	COG3852@1|root,COG3852@2|Bacteria,3Y9A1@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_2606962_1	234267.Acid_7711	5.51e-153	489.0	COG1702@1|root,COG1702@2|Bacteria,3Y3RM@57723|Acidobacteria	57723|Acidobacteria	T	PFAM PhoH family protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
TLS2_k127_2606962_10	234267.Acid_7712	6.655e-42	158.0	COG0319@1|root,COG0319@2|Bacteria,3Y53R@57723|Acidobacteria	57723|Acidobacteria	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
TLS2_k127_2606962_3	234267.Acid_7713	3.131e-129	426.0	COG1253@1|root,COG1253@2|Bacteria,3Y3MC@57723|Acidobacteria	57723|Acidobacteria	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_2606962_4	234267.Acid_7714	9.732e-99	338.0	COG1159@1|root,COG1159@2|Bacteria,3Y2GE@57723|Acidobacteria	57723|Acidobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
TLS2_k127_2606962_11	1267535.KB906767_gene5115	3.592e-15	78.0	COG2823@1|root,COG2823@2|Bacteria,3Y8T3@57723|Acidobacteria	57723|Acidobacteria	S	BON domain	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
TLS2_k127_2606962_9	1195236.CTER_0563	1.027e-43	175.0	COG0145@1|root,COG0145@2|Bacteria,1V3GN@1239|Firmicutes,25DNJ@186801|Clostridia,3WPEF@541000|Ruminococcaceae	186801|Clostridia	EQ	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
TLS2_k127_2606962_8	945713.IALB_1818	1.01e-55	205.0	COG0646@1|root,COG0646@2|Bacteria	2|Bacteria	E	methionine synthase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
TLS2_k127_2606962_2	1183438.GKIL_3395	5.713e-139	475.0	COG0515@1|root,COG0515@2|Bacteria,1G3GV@1117|Cyanobacteria	1183438.GKIL_3395|-	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
TLS2_k127_2606962_0	1128421.JAGA01000001_gene2197	1.972e-211	670.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
TLS2_k127_2606962_12	234267.Acid_1457	1.291e-13	73.0	2A0AF@1|root,30NDV@2|Bacteria,3Y93U@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2606962_5	1340493.JNIF01000004_gene393	3.434e-92	320.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
TLS2_k127_2606962_7	530564.Psta_0338	1.25e-56	216.0	COG1194@1|root,COG1194@2|Bacteria,2IY33@203682|Planctomycetes	203682|Planctomycetes	L	COG1194 A G-specific DNA glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
TLS2_k127_2607363_1	204669.Acid345_0466	4.359e-21	94.0	COG0508@1|root,COG4770@1|root,COG4799@1|root,COG0508@2|Bacteria,COG4770@2|Bacteria,COG4799@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	-	-	2.1.3.1,2.1.3.15,2.3.1.12,3.2.1.1,6.4.1.3	ko:K00627,ko:K01176,ko:K01966,ko:K03646,ko:K17489	ko00010,ko00020,ko00280,ko00500,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04973,map00010,map00020,map00280,map00500,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map04973	M00307,M00373,M00741	R00209,R00353,R01859,R02108,R02112,R02569,R11262	RC00004,RC00040,RC00097,RC00609,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko02000	2.C.1.2	GH13	-	ACC_central,Alpha-amylase,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CBM_48,CPSase_L_D2,Carboxyl_trans,DUF349,Gram_pos_anchor,PUD,YSIRK_signal
TLS2_k127_2607363_0	234267.Acid_3077	0.0	1217.0	COG0304@1|root,COG3321@1|root,COG4221@1|root,COG0304@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,3Y347@57723|Acidobacteria	57723|Acidobacteria	Q	Acyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
TLS2_k127_260837_1	545264.KB898751_gene2556	2.491e-13	70.0	COG1487@1|root,COG1487@2|Bacteria,1RJDP@1224|Proteobacteria,1SA6Q@1236|Gammaproteobacteria,1WZ0N@135613|Chromatiales	135613|Chromatiales	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_260837_3	498211.CJA_1576	1.128e-09	61.0	COG1487@1|root,COG1487@2|Bacteria,1RJDP@1224|Proteobacteria,1SA6Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
TLS2_k127_260837_2	930169.B5T_04013	3.77e-12	70.0	2E38E@1|root,32Y84@2|Bacteria,1N84V@1224|Proteobacteria,1SCI1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_260837_0	234267.Acid_6228	1.132e-157	503.0	COG1088@1|root,COG1088@2|Bacteria,3Y3E7@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_2611666_7	1267535.KB906767_gene965	7.121e-48	175.0	COG4975@1|root,COG4975@2|Bacteria,3Y6YG@57723|Acidobacteria	57723|Acidobacteria	G	Ureide permease	-	-	-	ko:K05340	-	-	-	-	ko00000,ko02000	2.A.7.5	-	-	Ureide_permease
TLS2_k127_2611666_4	234267.Acid_1476	2.133e-105	358.0	COG0013@1|root,COG0013@2|Bacteria,3Y4AR@57723|Acidobacteria	57723|Acidobacteria	J	Threonyl and Alanyl tRNA synthetase second additional domain	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS2_k127_2611666_1	234267.Acid_3581	2.606e-124	419.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,NPCBM_assoc,PEGA
TLS2_k127_2611666_6	234267.Acid_3580	5.331e-56	197.0	COG0838@1|root,COG0838@2|Bacteria,3Y59B@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TLS2_k127_2611666_5	234267.Acid_3878	3.279e-97	321.0	COG1045@1|root,COG1045@2|Bacteria,3Y4HF@57723|Acidobacteria	57723|Acidobacteria	E	Bacterial transferase hexapeptide (six repeats)	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
TLS2_k127_2611666_0	234267.Acid_5075	1.926e-144	473.0	COG0741@1|root,COG0741@2|Bacteria	2|Bacteria	M	lytic transglycosylase activity	-	-	-	ko:K08307,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	LysM,Peptidase_M23,SLT
TLS2_k127_2611666_2	929703.KE386491_gene3159	1.086e-116	382.0	2BZ6M@1|root,2Z7HW@2|Bacteria,4NDZE@976|Bacteroidetes,47M8V@768503|Cytophagia	976|Bacteroidetes	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_2611666_3	234267.Acid_6336	1.412e-114	377.0	COG2017@1|root,COG2017@2|Bacteria,3Y6TJ@57723|Acidobacteria	57723|Acidobacteria	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2611666_8	1198114.AciX9_2893	3.199e-35	147.0	COG0601@1|root,COG0601@2|Bacteria,3Y96K@57723|Acidobacteria	57723|Acidobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_2611666_9	1340493.JNIF01000004_gene307	7.458e-33	139.0	COG1173@1|root,COG1173@2|Bacteria,3Y8PY@57723|Acidobacteria	57723|Acidobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_2643692_2	1340493.JNIF01000003_gene1479	7.993e-28	126.0	COG2227@1|root,COG2227@2|Bacteria,3Y8MU@57723|Acidobacteria	57723|Acidobacteria	H	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_2643692_1	861299.J421_4289	6.079e-84	284.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	ppgK	-	2.7.1.2,2.7.1.63,5.3.1.9	ko:K00845,ko:K00886,ko:K01810	ko00010,ko00030,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114,M00549	R00299,R01600,R01786,R02187,R02189,R02739,R02740,R03321	RC00002,RC00017,RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ROK
TLS2_k127_2643692_0	234267.Acid_6791	3.82e-136	439.0	COG4974@1|root,COG4974@2|Bacteria,3Y73V@57723|Acidobacteria	57723|Acidobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_2644211_2	251221.35211765	1.825e-63	230.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_2644211_1	234267.Acid_1929	2.914e-165	550.0	COG2120@1|root,COG2120@2|Bacteria,3Y3BV@57723|Acidobacteria	57723|Acidobacteria	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc,PIG-L
TLS2_k127_2644211_0	234267.Acid_3343	2.407e-218	688.0	COG4948@1|root,COG4948@2|Bacteria,3Y61U@57723|Acidobacteria	57723|Acidobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_2644211_3	234267.Acid_5607	9.852e-56	204.0	COG0454@1|root,COG0456@2|Bacteria,3Y8PW@57723|Acidobacteria	57723|Acidobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2644211_4	234267.Acid_2792	1.226e-50	204.0	COG2202@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,3Y4XJ@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_9
TLS2_k127_2644211_5	706587.Desti_2130	1.896e-11	66.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,43AV8@68525|delta/epsilon subdivisions,2X69B@28221|Deltaproteobacteria,2MSKC@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_2649054_0	933262.AXAM01000057_gene1552	1.65e-191	617.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,2MJ5N@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Signal transducing histidine kinase, homodimeric	cheA34H	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
TLS2_k127_2649054_2	1448139.AI20_14115	0.0002746	48.0	COG1366@1|root,COG1366@2|Bacteria,1N8B6@1224|Proteobacteria,1SDVH@1236|Gammaproteobacteria,1Y65X@135624|Aeromonadales	135624|Aeromonadales	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
TLS2_k127_2649054_1	930166.CD58_11110	3.439e-13	78.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NT	chemotaxis, protein	VPA0491	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,HBM,MCPsignal
TLS2_k127_2650674_1	1198114.AciX9_2894	6.199e-22	99.0	COG1173@1|root,COG1173@2|Bacteria,3Y8PY@57723|Acidobacteria	57723|Acidobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_2650674_0	1340493.JNIF01000004_gene306	4.724e-139	459.0	COG0747@1|root,COG0747@2|Bacteria,3Y44K@57723|Acidobacteria	57723|Acidobacteria	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_2650674_2	1306990.BARG01000052_gene6196	5.482e-13	72.0	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,BPD_transp_1,oligo_HPY
TLS2_k127_2654588_4	472759.Nhal_3295	4.605e-09	60.0	COG1680@1|root,COG1680@2|Bacteria,1NPBV@1224|Proteobacteria,1SQWZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Domain of unknown function (DUF4185)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185
TLS2_k127_2654588_0	1250232.JQNJ01000001_gene1869	2.813e-164	528.0	COG4733@1|root,COG4733@2|Bacteria,4PNY1@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
TLS2_k127_2654588_5	118173.KB235914_gene495	1.197e-07	55.0	COG2402@1|root,COG2402@2|Bacteria,1G79E@1117|Cyanobacteria,1HBMU@1150|Oscillatoriales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_2654588_1	1504672.669785740	1.014e-23	103.0	COG2402@1|root,COG2402@2|Bacteria,1PZKR@1224|Proteobacteria,2W40N@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2654588_3	765420.OSCT_1752	1.892e-17	83.0	COG1724@1|root,COG1724@2|Bacteria,2G9TH@200795|Chloroflexi	200795|Chloroflexi	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
TLS2_k127_2654588_2	323261.Noc_1108	4.018e-20	91.0	COG1598@1|root,COG1598@2|Bacteria,1NPTZ@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2657785_5	404380.Gbem_0827	9.89e-07	55.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,42NDF@68525|delta/epsilon subdivisions,2WJPS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS2_k127_2657785_1	234267.Acid_3641	1.132e-157	503.0	COG2382@1|root,COG2382@2|Bacteria	2|Bacteria	P	enterobactin catabolic process	-	-	3.6.3.38	ko:K07214,ko:K09689	ko02010,map02010	M00249	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.101	-	-	Esterase
TLS2_k127_2657785_2	234267.Acid_7430	3.159e-118	388.0	COG0604@1|root,COG0604@2|Bacteria,3Y35U@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_2657785_3	234267.Acid_7433	9.727e-108	362.0	COG0006@1|root,COG0006@2|Bacteria,3Y3IN@57723|Acidobacteria	57723|Acidobacteria	E	PFAM peptidase M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
TLS2_k127_2657785_4	1267535.KB906767_gene4314	1.498e-42	162.0	COG0511@1|root,COG0511@2|Bacteria,3Y4W8@57723|Acidobacteria,2JJHQ@204432|Acidobacteriia	204432|Acidobacteriia	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
TLS2_k127_2657785_0	1267535.KB906767_gene4313	3.678e-159	508.0	COG0439@1|root,COG0439@2|Bacteria,3Y2QZ@57723|Acidobacteria,2JIFS@204432|Acidobacteriia	204432|Acidobacteriia	I	acetyl-CoA carboxylase, biotin carboxylase	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TLS2_k127_2658772_3	234267.Acid_6670	2.828e-49	177.0	COG0216@1|root,COG0216@2|Bacteria,3Y2N9@57723|Acidobacteria	57723|Acidobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS2_k127_2658772_2	234267.Acid_6669	2.156e-92	311.0	COG2890@1|root,COG2890@2|Bacteria,3Y4KU@57723|Acidobacteria	57723|Acidobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
TLS2_k127_2658772_0	234267.Acid_0850	5.552e-172	549.0	COG0389@1|root,COG0389@2|Bacteria,3Y3NY@57723|Acidobacteria	57723|Acidobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
TLS2_k127_2658772_1	1396141.BATP01000005_gene6048	1.254e-133	450.0	COG1785@1|root,COG1785@2|Bacteria,46X6X@74201|Verrucomicrobia,2IUSG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Alkaline phosphatase homologues	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
TLS2_k127_2658772_4	243090.RB2837	0.000172	49.0	COG1520@1|root,COG1520@2|Bacteria,2IXST@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_2660265_2	1267534.KB906758_gene2085	7.61e-25	112.0	COG0577@1|root,COG0577@2|Bacteria,3Y3XI@57723|Acidobacteria,2JI94@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_2660265_1	1267533.KB906740_gene380	3.518e-95	325.0	COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria,2JI8C@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_2660265_0	1340493.JNIF01000003_gene1786	1.599e-124	405.0	COG0162@1|root,COG0162@2|Bacteria,3Y2NC@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TLS2_k127_2670185_2	886293.Sinac_7494	1.072e-134	433.0	COG4102@1|root,COG4102@2|Bacteria,2IXKR@203682|Planctomycetes	203682|Planctomycetes	T	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_2670185_1	234267.Acid_4267	5.966e-296	930.0	COG0577@1|root,COG0577@2|Bacteria,3Y3U3@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_2670185_0	401053.AciPR4_1573	0.0	1072.0	COG1629@1|root,COG4771@2|Bacteria,3Y368@57723|Acidobacteria,2JKVQ@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_2694329_3	886293.Sinac_4862	9.394e-09	63.0	COG3618@1|root,COG3618@2|Bacteria,2IY4K@203682|Planctomycetes	203682|Planctomycetes	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_2694329_2	204669.Acid345_0439	5.201e-18	91.0	COG1845@1|root,COG1845@2|Bacteria,3Y2KJ@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
TLS2_k127_2694329_0	234267.Acid_2141	3.469e-124	406.0	COG0111@1|root,COG0111@2|Bacteria,3Y3VD@57723|Acidobacteria	57723|Acidobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh_C
TLS2_k127_2694329_1	1095769.CAHF01000011_gene2293	1.821e-24	102.0	COG1764@1|root,COG1764@2|Bacteria,1RH9U@1224|Proteobacteria,2VTKP@28216|Betaproteobacteria,474QB@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	OsmC-like protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
TLS2_k127_2697108_2	1487953.JMKF01000035_gene1169	2.828e-45	173.0	COG4976@1|root,COG4976@2|Bacteria,1G290@1117|Cyanobacteria,1H9JI@1150|Oscillatoriales	1117|Cyanobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_2697108_3	234267.Acid_7654	1.243e-24	111.0	COG0629@1|root,COG0629@2|Bacteria,3Y4QE@57723|Acidobacteria	57723|Acidobacteria	L	PFAM single-strand binding protein Primosomal replication protein n	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_2697108_1	717605.Theco_3127	5.225e-110	375.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,4HDSE@91061|Bacilli,26V76@186822|Paenibacillaceae	91061|Bacilli	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_2697108_0	1267535.KB906767_gene1954	7.924e-126	418.0	2AG8X@1|root,316EB@2|Bacteria,3Y75Y@57723|Acidobacteria,2JNUP@204432|Acidobacteriia	204432|Acidobacteriia	S	Plasmid encoded RepA protein	-	-	-	-	-	-	-	-	-	-	-	-	RepA_C
TLS2_k127_269775_6	234267.Acid_0514	5.922e-15	77.0	COG1729@1|root,COG1729@2|Bacteria,3Y3H6@57723|Acidobacteria	57723|Acidobacteria	S	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
TLS2_k127_269775_1	1340493.JNIF01000003_gene3057	1.6e-122	398.0	COG4146@1|root,COG4146@2|Bacteria	2|Bacteria	S	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
TLS2_k127_269775_5	234267.Acid_0890	3.028e-15	82.0	2C9DB@1|root,2ZU09@2|Bacteria,3Y8XC@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_269775_0	1267535.KB906767_gene2722	4.044e-221	703.0	COG0138@1|root,COG0138@2|Bacteria,3Y2QI@57723|Acidobacteria,2JHSU@204432|Acidobacteriia	204432|Acidobacteriia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
TLS2_k127_269775_3	234267.Acid_4980	3.928e-40	155.0	COG1393@1|root,COG1393@2|Bacteria,3Y7VT@57723|Acidobacteria	57723|Acidobacteria	P	ArsC family	-	-	-	-	-	-	-	-	-	-	-	-	ArsC
TLS2_k127_269775_2	1340493.JNIF01000003_gene3071	6.403e-58	206.0	2CNUX@1|root,32SHU@2|Bacteria,3Y87T@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF2760)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2760
TLS2_k127_269775_4	1267535.KB906767_gene2594	8.115e-21	94.0	COG0443@1|root,COG0443@2|Bacteria,3Y661@57723|Acidobacteria	57723|Acidobacteria	O	MreB/Mbl protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
TLS2_k127_2699181_0	344747.PM8797T_15948	1.045e-109	370.0	COG0673@1|root,COG0673@2|Bacteria,2IWRC@203682|Planctomycetes	203682|Planctomycetes	S	COGs COG0673 dehydrogenase and related protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_27132_3	1331060.RLDS_18740	0.0003982	46.0	COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,2U06F@28211|Alphaproteobacteria,2KCUU@204457|Sphingomonadales	204457|Sphingomonadales	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_27132_1	357808.RoseRS_1362	9.304e-44	169.0	COG1028@1|root,COG1028@2|Bacteria,2GAK3@200795|Chloroflexi,3774Y@32061|Chloroflexia	32061|Chloroflexia	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_27132_0	861299.J421_1196	1.954e-90	313.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	exuT	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
TLS2_k127_27132_2	1132855.KB913035_gene1951	3.81e-08	61.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2VKD6@28216|Betaproteobacteria,2KNE8@206350|Nitrosomonadales	206350|Nitrosomonadales	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
TLS2_k127_2716696_0	1267535.KB906767_gene618	2.542e-243	773.0	COG0577@1|root,COG0577@2|Bacteria,3Y38T@57723|Acidobacteria,2JKAN@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_2716696_1	1340493.JNIF01000004_gene239	7.145e-199	629.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_2716696_3	1340493.JNIF01000003_gene3753	1.736e-12	78.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,Big_3_5,Glyco_hydro_25,Glyco_hydro_92,SLH,WD40,fn3
TLS2_k127_2716696_4	1267535.KB906767_gene3903	2.998e-06	58.0	2E1AY@1|root,32WQW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2716696_2	518766.Rmar_1357	7.717e-60	224.0	COG1680@1|root,COG1680@2|Bacteria,4NJ0F@976|Bacteroidetes	976|Bacteroidetes	V	Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_2717926_2	426117.M446_1379	0.000357	50.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,2TWGD@28211|Alphaproteobacteria,1JT6R@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	NHL repeat	MA20_20600	-	-	-	-	-	-	-	-	-	-	-	NHL
TLS2_k127_2717926_1	1316927.ATKI01000057_gene4470	1.189e-26	113.0	COG1396@1|root,COG1396@2|Bacteria,1QV4V@1224|Proteobacteria,1T28H@1236|Gammaproteobacteria,1YUI1@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_37
TLS2_k127_2717926_0	1100720.ALKN01000062_gene1407	4.706e-46	169.0	COG4683@1|root,COG4683@2|Bacteria,1MZIY@1224|Proteobacteria,2VWKG@28216|Betaproteobacteria,4AIHW@80864|Comamonadaceae	28216|Betaproteobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
TLS2_k127_2720430_1	234267.Acid_3076	2.996e-41	161.0	COG2091@1|root,COG2091@2|Bacteria,3Y8HB@57723|Acidobacteria	57723|Acidobacteria	H	4'-phosphopantetheinyl transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_2720430_0	204669.Acid345_0466	0.0	2063.0	COG0508@1|root,COG4770@1|root,COG4799@1|root,COG0508@2|Bacteria,COG4770@2|Bacteria,COG4799@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	-	-	2.1.3.1,2.1.3.15,2.3.1.12,3.2.1.1,6.4.1.3	ko:K00627,ko:K01176,ko:K01966,ko:K03646,ko:K17489	ko00010,ko00020,ko00280,ko00500,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04973,map00010,map00020,map00280,map00500,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map04973	M00307,M00373,M00741	R00209,R00353,R01859,R02108,R02112,R02569,R11262	RC00004,RC00040,RC00097,RC00609,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko02000	2.C.1.2	GH13	-	ACC_central,Alpha-amylase,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CBM_48,CPSase_L_D2,Carboxyl_trans,DUF349,Gram_pos_anchor,PUD,YSIRK_signal
TLS2_k127_2720912_2	234267.Acid_2220	1.925e-38	151.0	COG1472@1|root,COG1472@2|Bacteria,3Y6UR@57723|Acidobacteria	57723|Acidobacteria	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
TLS2_k127_2720912_3	234267.Acid_2219	1.096e-33	134.0	COG0784@1|root,COG0784@2|Bacteria,3Y4W5@57723|Acidobacteria	57723|Acidobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_2720912_0	1340493.JNIF01000004_gene505	1.326e-162	519.0	COG2304@1|root,COG2304@2|Bacteria,3Y3QQ@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
TLS2_k127_2720912_1	1267535.KB906767_gene3394	1.197e-47	173.0	COG0129@1|root,COG0129@2|Bacteria,3Y372@57723|Acidobacteria,2JIK1@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the IlvD Edd family	-	-	-	-	-	-	-	-	-	-	-	-	ILVD_EDD
TLS2_k127_2736661_1	1267535.KB906767_gene5217	2.232e-174	554.0	COG0183@1|root,COG0183@2|Bacteria,3Y7RP@57723|Acidobacteria	57723|Acidobacteria	I	Thiolase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_2736661_4	1267535.KB906767_gene5218	2.019e-59	213.0	COG1595@1|root,COG1595@2|Bacteria,3Y7JF@57723|Acidobacteria	57723|Acidobacteria	K	Bacterial regulatory proteins, luxR family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2736661_3	234267.Acid_0371	1.608e-92	316.0	2C5RF@1|root,33T7W@2|Bacteria,3Y6IQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2736661_5	1267535.KB906767_gene96	2.593e-16	87.0	2C5W1@1|root,2ZWMD@2|Bacteria,3Y8VN@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2736661_0	1396418.BATQ01000113_gene4654	2.588e-192	608.0	COG2327@1|root,COG2327@2|Bacteria,46U6R@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
TLS2_k127_2736661_2	502025.Hoch_6849	3.472e-99	331.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,43EAF@68525|delta/epsilon subdivisions,2X34W@28221|Deltaproteobacteria,2YUA3@29|Myxococcales	28221|Deltaproteobacteria	S	N-terminal domain of oxidoreductase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
TLS2_k127_2739759_0	518766.Rmar_2421	7.783e-32	128.0	COG1569@1|root,COG1569@2|Bacteria	2|Bacteria	S	PIN domain	-	-	-	ko:K07063	-	-	-	-	ko00000	-	-	-	PIN_3
TLS2_k127_2739759_1	671143.DAMO_1892	5.427e-22	98.0	COG3905@1|root,COG3905@2|Bacteria	2|Bacteria	K	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
TLS2_k127_2740111_1	1142394.PSMK_30610	3.174e-17	87.0	COG3039@1|root,COG3039@2|Bacteria,2J1M4@203682|Planctomycetes	203682|Planctomycetes	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
TLS2_k127_2740111_2	388051.AUFE01000075_gene3066	3.534e-10	64.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VK9J@28216|Betaproteobacteria,1K4IS@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Product type h extrachromosomal origin	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
TLS2_k127_2740111_0	1395571.TMS3_0107590	6.258e-18	87.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RRUS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	hmm pf01609	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
TLS2_k127_2740111_3	1278073.MYSTI_02266	0.0002294	44.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
TLS2_k127_2745997_7	1198452.Jab_1c03030	2.902e-10	61.0	COG0346@1|root,COG0346@2|Bacteria,1RHRF@1224|Proteobacteria	1224|Proteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_2745997_4	1366050.N234_23380	8.102e-68	234.0	COG5649@1|root,COG5649@2|Bacteria,1RDDG@1224|Proteobacteria,2W0C7@28216|Betaproteobacteria,1KD98@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS2_k127_2745997_1	1163617.SCD_n02147	3.281e-85	296.0	COG0457@1|root,COG0457@2|Bacteria,1RCR5@1224|Proteobacteria,2VP8V@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF4236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4236
TLS2_k127_2745997_2	344747.PM8797T_06220	2.571e-82	281.0	COG2126@1|root,COG2126@2|Bacteria,2IZ7U@203682|Planctomycetes	2|Bacteria	J	COG1226 Kef-type K transport systems	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2
TLS2_k127_2745997_8	29495.EA26_19250	1.096e-08	61.0	COG1321@1|root,COG1321@2|Bacteria,1N90S@1224|Proteobacteria,1STXK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	Fe_dep_repress,LexA_DNA_bind
TLS2_k127_2745997_6	1502851.FG93_04841	1.536e-16	87.0	COG0467@1|root,COG0467@2|Bacteria,1MWEF@1224|Proteobacteria,2TUR4@28211|Alphaproteobacteria,3JU3G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	DnaB-like helicase C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaB_C
TLS2_k127_2745997_3	1265313.HRUBRA_01348	2.23e-70	256.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_2745997_0	863365.XHC_3771	1.815e-174	567.0	COG3177@1|root,COG3177@2|Bacteria,1MXWY@1224|Proteobacteria,1RXR7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
TLS2_k127_2745997_5	426117.M446_1241	2.081e-23	99.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,1JTBI@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM biotin lipoyl attachment domain-containing protein	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
TLS2_k127_2750946_3	1267535.KB906767_gene310	9.052e-148	474.0	COG3964@1|root,COG3964@2|Bacteria,3Y42F@57723|Acidobacteria	57723|Acidobacteria	S	amidohydrolase	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
TLS2_k127_2750946_5	1267535.KB906767_gene2372	7.767e-137	445.0	COG0761@1|root,COG0761@2|Bacteria,3Y40M@57723|Acidobacteria,2JIXC@204432|Acidobacteriia	204432|Acidobacteriia	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
TLS2_k127_2750946_7	1267535.KB906767_gene2371	2.427e-119	405.0	COG1657@1|root,COG1657@2|Bacteria,3Y37N@57723|Acidobacteria,2JIJP@204432|Acidobacteriia	204432|Acidobacteriia	I	Squalene-hopene cyclase C-terminal domain	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
TLS2_k127_2750946_0	1340493.JNIF01000003_gene3883	1.814e-175	556.0	COG0535@1|root,COG0535@2|Bacteria,3Y2JV@57723|Acidobacteria	57723|Acidobacteria	S	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_14,Radical_SAM
TLS2_k127_2750946_4	234267.Acid_1261	9.148e-139	447.0	COG0451@1|root,COG0451@2|Bacteria,3Y41S@57723|Acidobacteria	57723|Acidobacteria	M	epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
TLS2_k127_2750946_9	765912.Thimo_3445	3.537e-17	89.0	COG0775@1|root,COG0775@2|Bacteria,1MY5S@1224|Proteobacteria,1RNSF@1236|Gammaproteobacteria,1WZQ1@135613|Chromatiales	135613|Chromatiales	F	other phosphorylase family 1	-	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_2750946_2	234267.Acid_1263	7.082e-165	527.0	COG1063@1|root,COG1063@2|Bacteria,3Y2H8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_2750946_1	234267.Acid_1264	7.783e-172	544.0	COG1063@1|root,COG1063@2|Bacteria,3Y30Y@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_2750946_6	234267.Acid_1265	2.205e-121	396.0	COG1562@1|root,COG1562@2|Bacteria,3Y3ZV@57723|Acidobacteria	57723|Acidobacteria	I	PFAM Squalene phytoene synthase	-	-	-	-	-	-	-	-	-	-	-	-	SQS_PSY
TLS2_k127_2750946_8	234267.Acid_1266	1.548e-104	348.0	COG1562@1|root,COG1562@2|Bacteria,3Y3YX@57723|Acidobacteria	57723|Acidobacteria	I	PFAM Squalene phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
TLS2_k127_2770399_4	234267.Acid_0487	2.27e-79	286.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
TLS2_k127_2770399_1	234267.Acid_1922	2.667e-205	647.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_2770399_2	1340493.JNIF01000003_gene1531	6.473e-128	421.0	COG1538@1|root,COG1538@2|Bacteria,3Y2KH@57723|Acidobacteria	57723|Acidobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
TLS2_k127_2770399_3	1340493.JNIF01000003_gene1530	3.63e-102	349.0	COG0845@1|root,COG0845@2|Bacteria,3Y3N7@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
TLS2_k127_2770399_0	1340493.JNIF01000003_gene1529	0.0	1076.0	COG3696@1|root,COG3696@2|Bacteria,3Y2U0@57723|Acidobacteria	57723|Acidobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
TLS2_k127_2773741_0	234267.Acid_6121	1.331e-51	188.0	COG3436@1|root,COG3436@2|Bacteria,3Y875@57723|Acidobacteria	57723|Acidobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
TLS2_k127_2773741_1	234267.Acid_7654	7.493e-10	62.0	COG0629@1|root,COG0629@2|Bacteria,3Y4QE@57723|Acidobacteria	57723|Acidobacteria	L	PFAM single-strand binding protein Primosomal replication protein n	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_27745_0	1267535.KB906767_gene2638	0.0	1118.0	COG2609@1|root,COG2609@2|Bacteria,3Y2M3@57723|Acidobacteria,2JHM5@204432|Acidobacteriia	204432|Acidobacteriia	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS2_k127_27745_11	234267.Acid_4928	4.157e-20	98.0	29ZWG@1|root,30MXU@2|Bacteria,3Y5VK@57723|Acidobacteria	57723|Acidobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_27745_4	234267.Acid_6299	2.768e-102	343.0	COG0130@1|root,COG0130@2|Bacteria,3Y3PG@57723|Acidobacteria	57723|Acidobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
TLS2_k127_27745_6	667632.KB890194_gene3502	3.396e-72	264.0	COG0840@1|root,COG4251@1|root,COG0840@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VJGY@28216|Betaproteobacteria,1KGEK@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HAMP,HATPase_c,HisKA,PAS,PAS_9,TarH
TLS2_k127_27745_8	234267.Acid_0018	3.263e-34	138.0	COG0789@1|root,COG0789@2|Bacteria,3Y56I@57723|Acidobacteria	57723|Acidobacteria	K	regulatory protein, MerR	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_27745_3	234267.Acid_0726	1.106e-165	525.0	COG0303@1|root,COG0303@2|Bacteria,3Y6V2@57723|Acidobacteria	57723|Acidobacteria	H	'Molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_27745_2	234267.Acid_7728	5.951e-192	608.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_27745_7	1267535.KB906767_gene342	6.166e-55	202.0	COG0726@1|root,COG0726@2|Bacteria,3Y4FK@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
TLS2_k127_27745_1	234267.Acid_7927	0.0	1049.0	COG0365@1|root,COG0365@2|Bacteria,3Y39K@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_27745_12	1278073.MYSTI_01210	2.609e-15	80.0	2E6QG@1|root,331AP@2|Bacteria,1N5WP@1224|Proteobacteria,42U29@68525|delta/epsilon subdivisions,2WQJ9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867
TLS2_k127_27745_13	1165096.ARWF01000001_gene1591	0.0002089	49.0	2C1V0@1|root,33BWD@2|Bacteria,1NIQG@1224|Proteobacteria,2W4IN@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_27745_9	1340493.JNIF01000003_gene1703	2.275e-32	134.0	COG0741@1|root,COG0741@2|Bacteria,3Y4SM@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Lytic transglycosylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TLS2_k127_27745_10	1267535.KB906767_gene4811	1.319e-30	129.0	COG0745@1|root,COG0745@2|Bacteria,3Y8QP@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_27745_5	1267535.KB906767_gene5303	3.003e-88	315.0	COG0642@1|root,COG3829@1|root,COG4251@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE3,GAF,GGDEF,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_2781526_2	234267.Acid_6187	2.385e-83	281.0	COG4102@1|root,COG4102@2|Bacteria,3Y6RN@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_2781526_0	234267.Acid_6186	1.615e-273	863.0	COG2010@1|root,COG2010@2|Bacteria,3Y6T1@57723|Acidobacteria	57723|Acidobacteria	C	cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_2781526_1	1267535.KB906767_gene607	1.432e-238	745.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,3Y34Y@57723|Acidobacteria,2JHQ9@204432|Acidobacteriia	204432|Acidobacteriia	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
TLS2_k127_2781676_0	234267.Acid_0922	0.0	1487.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,3Y7VB@57723|Acidobacteria	57723|Acidobacteria	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
TLS2_k127_2781676_1	234267.Acid_0921	5.562e-211	671.0	COG3581@1|root,COG3581@2|Bacteria	2|Bacteria	I	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2781676_2	1123371.ATXH01000021_gene1117	3.034e-205	666.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GHDG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
TLS2_k127_2781676_3	221288.JH992901_gene3895	3.12e-160	509.0	COG0715@1|root,COG0715@2|Bacteria,1GFIM@1117|Cyanobacteria	1117|Cyanobacteria	P	Protein of unknown function (DUF3500)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3500
TLS2_k127_2782541_3	472759.Nhal_0278	5.501e-18	85.0	2EBQI@1|root,335QJ@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
TLS2_k127_2782541_1	32057.KB217483_gene9954	1.953e-42	171.0	2E6C0@1|root,330ZT@2|Bacteria,1G6AK@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2782541_0	1123242.JH636435_gene1142	1.144e-52	202.0	28MFE@1|root,2ZASW@2|Bacteria,2J1ME@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
TLS2_k127_2782541_2	1210884.HG799462_gene8866	4.215e-31	129.0	arCOG05205@1|root,32ZUE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2792356_1	234267.Acid_0130	8.612e-101	331.0	COG0624@1|root,COG0624@2|Bacteria,3Y3TZ@57723|Acidobacteria	57723|Acidobacteria	E	peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_2792356_0	1340493.JNIF01000004_gene702	8.528e-185	592.0	COG0728@1|root,COG0728@2|Bacteria,3Y31G@57723|Acidobacteria	57723|Acidobacteria	S	virulence factor MVIN family protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TLS2_k127_2792356_3	234267.Acid_0817	1.195e-70	251.0	COG1579@1|root,COG1579@2|Bacteria,3Y509@57723|Acidobacteria	57723|Acidobacteria	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
TLS2_k127_2792356_2	234267.Acid_7675	3.492e-86	289.0	COG0480@1|root,COG0480@2|Bacteria,3Y2RR@57723|Acidobacteria	57723|Acidobacteria	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_2796412_7	234267.Acid_0297	2.876e-50	188.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,LCAT,PGAP1
TLS2_k127_2796412_3	1267535.KB906767_gene1306	2.08e-101	340.0	COG1194@1|root,COG1194@2|Bacteria,3Y50Y@57723|Acidobacteria,2JHYP@204432|Acidobacteriia	204432|Acidobacteriia	L	FES	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TLS2_k127_2796412_5	1340493.JNIF01000004_gene117	1.555e-59	216.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	AXE1,DLH,Peptidase_S9
TLS2_k127_2796412_4	1340493.JNIF01000003_gene2627	2.659e-77	276.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_2796412_0	234267.Acid_7008	7.62e-211	663.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_2796412_9	313596.RB2501_01236	5.517e-17	96.0	2C0EP@1|root,33T39@2|Bacteria,4P064@976|Bacteroidetes,1I8AP@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2796412_1	1089550.ATTH01000001_gene1831	4.636e-189	624.0	COG0515@1|root,COG0515@2|Bacteria,4NPN9@976|Bacteroidetes,1FJI6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	NERD,Pkinase,TPR_12,TPR_8
TLS2_k127_2796412_8	1267533.KB906738_gene2158	1.765e-44	168.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
TLS2_k127_2796412_6	1283300.ATXB01000002_gene3078	6.21e-57	214.0	COG2202@1|root,COG2208@1|root,COG3290@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2208@2|Bacteria,COG3290@2|Bacteria,COG3829@2|Bacteria,1RGZF@1224|Proteobacteria,1S6GG@1236|Gammaproteobacteria,1XDM4@135618|Methylococcales	135618|Methylococcales	KT	PFAM Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	PAS_9,SpoIIE
TLS2_k127_2796412_2	1444712.BN1013_00060	3.487e-104	355.0	COG0399@1|root,COG0399@2|Bacteria,2JFE1@204428|Chlamydiae	204428|Chlamydiae	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	1.17.1.1,2.6.1.98	ko:K12452,ko:K13017	ko00520,map00520	-	R03391,R03392,R10141	RC00006,RC00230,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_2805745_4	1232410.KI421412_gene406	6.597e-32	136.0	COG1193@1|root,COG1193@2|Bacteria,1QYV7@1224|Proteobacteria	1224|Proteobacteria	L	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2805745_3	234267.Acid_5566	5.788e-51	188.0	COG0428@1|root,COG0428@2|Bacteria,3Y8C3@57723|Acidobacteria	57723|Acidobacteria	P	transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2805745_1	234267.Acid_7160	1.152e-182	582.0	COG0154@1|root,COG0154@2|Bacteria,3Y6WA@57723|Acidobacteria	57723|Acidobacteria	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
TLS2_k127_2805745_0	234267.Acid_7159	4.28e-216	681.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,3Y2Y4@57723|Acidobacteria	57723|Acidobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	-	-	1.1.1.25,4.2.1.10	ko:K00014,ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
TLS2_k127_2805745_2	1123508.JH636439_gene1075	1.206e-114	387.0	COG0412@1|root,COG0412@2|Bacteria,2IYMM@203682|Planctomycetes	203682|Planctomycetes	Q	COG0412 Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TLS2_k127_2805745_5	1449357.JQLK01000005_gene2339	1.437e-15	80.0	COG0434@1|root,COG0434@2|Bacteria,1WJ8P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	BtpA family	-	-	-	ko:K06971	-	-	-	-	ko00000	-	-	-	BtpA
TLS2_k127_2805745_7	1168034.FH5T_08655	0.0003791	49.0	COG0434@1|root,COG0434@2|Bacteria,4P0R6@976|Bacteroidetes	976|Bacteroidetes	S	BtpA family	-	-	-	ko:K06971	-	-	-	-	ko00000	-	-	-	BtpA
TLS2_k127_2814949_0	234267.Acid_1908	2.69e-156	501.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,3Y339@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
TLS2_k127_2814949_4	644282.Deba_2778	4.934e-24	117.0	COG1639@1|root,COG1639@2|Bacteria,1RCW6@1224|Proteobacteria,43AQW@68525|delta/epsilon subdivisions,2X64U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TLS2_k127_2814949_1	1123229.AUBC01000007_gene117	6.669e-114	379.0	COG0475@1|root,COG0475@2|Bacteria,1PK6R@1224|Proteobacteria,2UA1A@28211|Alphaproteobacteria,3K5UD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS2_k127_2814949_3	1340493.JNIF01000003_gene4327	6.298e-37	147.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Thioredoxin_8
TLS2_k127_2814949_2	1191523.MROS_1419	2.808e-41	158.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_281869_3	234267.Acid_5255	7.819e-58	211.0	2B11W@1|root,31TFA@2|Bacteria,3Y4Z8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_281869_2	1382359.JIAL01000001_gene2002	5.178e-98	333.0	COG1609@1|root,COG1609@2|Bacteria,3Y424@57723|Acidobacteria,2JKR6@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_281869_0	234267.Acid_2734	8.077e-210	690.0	COG1629@1|root,COG4771@2|Bacteria,3Y2WI@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_281869_9	1042377.AFPJ01000036_gene1224	1.33e-12	79.0	COG1957@1|root,COG1957@2|Bacteria,1R49G@1224|Proteobacteria,1RZM4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the IUNH family	-	-	-	-	-	-	-	-	-	-	-	-	IU_nuc_hydro
TLS2_k127_281869_1	234267.Acid_5324	6.586e-119	396.0	COG2271@1|root,COG2271@2|Bacteria,3Y47N@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
TLS2_k127_281869_7	398512.JQKC01000002_gene1989	2.021e-44	167.0	COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,3WJA1@541000|Ruminococcaceae	186801|Clostridia	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
TLS2_k127_281869_5	234267.Acid_1467	4.539e-55	198.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_281869_4	1267535.KB906767_gene1057	1.834e-57	207.0	COG1629@1|root,COG4771@2|Bacteria,3Y36N@57723|Acidobacteria,2JI4W@204432|Acidobacteriia	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_2822632_2	234267.Acid_6096	5.271e-16	83.0	28ZWN@1|root,2ZMM4@2|Bacteria,3Y8RZ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2822632_1	880070.Cycma_2024	9.991e-49	183.0	2DZG0@1|root,32V9P@2|Bacteria,4NTFA@976|Bacteroidetes,47RQH@768503|Cytophagia	976|Bacteroidetes	S	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
TLS2_k127_2822632_0	1267535.KB906767_gene4445	1.513e-216	680.0	COG1884@1|root,COG1884@2|Bacteria,3Y2PQ@57723|Acidobacteria,2JHJN@204432|Acidobacteriia	204432|Acidobacteriia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS2_k127_2829085_0	204669.Acid345_1118	6.987e-48	173.0	COG3861@1|root,COG3861@2|Bacteria,3Y5WZ@57723|Acidobacteria,2JM78@204432|Acidobacteriia	204432|Acidobacteriia	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
TLS2_k127_2829085_3	264201.pc1171	6.816e-22	100.0	COG2823@1|root,COG2823@2|Bacteria,2JGHK@204428|Chlamydiae	204428|Chlamydiae	S	BON domain	osmY	-	-	-	-	-	-	-	-	-	-	-	BON
TLS2_k127_2829085_1	1403819.BATR01000016_gene491	3.499e-27	112.0	COG2261@1|root,COG2261@2|Bacteria	2|Bacteria	S	Transglycosylase associated protein	MA20_40075	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS2_k127_2829085_5	555793.WSK_3410	3.827e-09	60.0	COG5592@1|root,COG5592@2|Bacteria,1RI8J@1224|Proteobacteria,2U7JS@28211|Alphaproteobacteria,2K402@204457|Sphingomonadales	204457|Sphingomonadales	S	Hemerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS2_k127_2829969_0	234267.Acid_5166	3.039e-162	515.0	COG0156@1|root,COG0156@2|Bacteria,3Y3J2@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_2829969_1	234267.Acid_2771	8.912e-33	135.0	2ENZH@1|root,33GKD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2830877_3	553973.CLOHYLEM_06014	3.465e-22	102.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,21XEX@1506553|Lachnoclostridium	186801|Clostridia	G	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
TLS2_k127_2830877_0	794846.AJQU01000100_gene5521	6.845e-116	389.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,4B9UV@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ATPases associated with a variety of cellular activities	rbsA	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
TLS2_k127_2830877_1	1089551.KE386572_gene1626	7.952e-79	274.0	COG1172@1|root,COG1172@2|Bacteria,1RBVF@1224|Proteobacteria,2U58Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
TLS2_k127_2830877_2	1089551.KE386572_gene1625	1.458e-51	187.0	COG1879@1|root,COG1879@2|Bacteria,1QJ9B@1224|Proteobacteria,2U8ZS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
TLS2_k127_2830921_5	926560.KE387023_gene2382	3.251e-12	68.0	COG0604@1|root,COG0604@2|Bacteria,1WM0U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
TLS2_k127_2830921_4	243159.AFE_2086	1.895e-36	144.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S607@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	hspA	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS2_k127_2830921_3	1123279.ATUS01000001_gene1755	2.11e-65	233.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1J64K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	helix_turn_helix, Lux Regulon	fixJ	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_2830921_2	395964.KE386496_gene3077	6.027e-88	305.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,3NAFU@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	fixL	-	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,MEDS,PAS,PAS_3,PAS_9
TLS2_k127_2830921_0	1283300.ATXB01000001_gene648	1.416e-114	389.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1XEH4@135618|Methylococcales	135618|Methylococcales	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
TLS2_k127_2830921_1	1123393.KB891330_gene873	5.559e-102	340.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,Response_reg
TLS2_k127_2834634_2	1267535.KB906767_gene3344	6.617e-74	254.0	COG0276@1|root,COG0276@2|Bacteria,3Y3B0@57723|Acidobacteria,2JHKQ@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
TLS2_k127_2834634_1	1267535.KB906767_gene3261	3.115e-112	371.0	COG1816@1|root,COG1816@2|Bacteria,3Y2R0@57723|Acidobacteria,2JINF@204432|Acidobacteriia	204432|Acidobacteriia	F	Adenosine/AMP deaminase	-	-	3.5.4.4,3.5.4.40	ko:K01488,ko:K18286	ko00130,ko00230,ko01100,ko01110,ko05340,map00130,map00230,map01100,map01110,map05340	-	R01560,R02556,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
TLS2_k127_2834634_0	234267.Acid_7335	0.0	1099.0	COG0296@1|root,COG0296@2|Bacteria,3Y33J@57723|Acidobacteria	57723|Acidobacteria	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	-	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TLS2_k127_2834634_3	234267.Acid_7444	3.728e-59	211.0	COG1022@1|root,COG1022@2|Bacteria,3Y2KU@57723|Acidobacteria	57723|Acidobacteria	I	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS2_k127_2836133_1	1173024.KI912150_gene1500	7.947e-159	507.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1FZX5@1117|Cyanobacteria,1JHD5@1189|Stigonemataceae	1117|Cyanobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
TLS2_k127_2836133_0	234267.Acid_7732	0.0	1618.0	COG0514@1|root,COG0550@1|root,COG0514@2|Bacteria,COG0550@2|Bacteria,3Y363@57723|Acidobacteria	57723|Acidobacteria	L	TIGRFAM ATP-dependent DNA helicase, RecQ family	-	-	3.6.4.12,5.99.1.2	ko:K03169,ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RecQ_Zn_bind
TLS2_k127_2836133_5	234267.Acid_7445	9.354e-54	201.0	COG0589@1|root,COG0589@2|Bacteria,3Y5Y7@57723|Acidobacteria	57723|Acidobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_2836133_2	1267535.KB906767_gene4262	1.679e-153	497.0	COG2271@1|root,COG2271@2|Bacteria,3Y6AJ@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_2836133_6	1068980.ARVW01000001_gene6654	1.992e-38	155.0	COG0329@1|root,COG0329@2|Bacteria,2ID43@201174|Actinobacteria	201174|Actinobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_2836133_4	1380394.JADL01000001_gene1957	3.11e-60	220.0	COG0111@1|root,COG0111@2|Bacteria,1R5FD@1224|Proteobacteria,2U0C0@28211|Alphaproteobacteria,2JSER@204441|Rhodospirillales	204441|Rhodospirillales	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh_C
TLS2_k127_2836133_3	1380600.AUYN01000009_gene1955	1.326e-76	261.0	COG4948@1|root,COG4948@2|Bacteria,4NIIJ@976|Bacteroidetes,1HZZD@117743|Flavobacteriia	976|Bacteroidetes	M	Mandelate racemase / muconate lactonizing enzyme, N-terminal domain	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_2837978_3	1458357.BG58_16970	2.382e-05	51.0	COG4974@1|root,COG4974@2|Bacteria,1QUHS@1224|Proteobacteria,2VMS7@28216|Betaproteobacteria,1JZVB@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_2837978_2	555779.Dthio_PD0022	9.749e-57	206.0	COG4974@1|root,COG4974@2|Bacteria,1RC0C@1224|Proteobacteria,42W1W@68525|delta/epsilon subdivisions,2WRTZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase IS66	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
TLS2_k127_2837978_1	1267535.KB906767_gene1214	3.6e-94	321.0	COG2433@1|root,COG2433@2|Bacteria,3Y7F1@57723|Acidobacteria	57723|Acidobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
TLS2_k127_2837978_0	1120948.KB903219_gene650	1.825e-106	346.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,4E1EE@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Alcohol dehydrogenase GroES-like domain	fdhA	-	1.2.1.46	ko:K00148	ko00625,ko00680,ko01100,ko01120,ko01200,map00625,map00680,map01100,map01120,map01200	-	R00604	RC00188	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
TLS2_k127_2838097_4	616991.JPOO01000003_gene698	7.832e-19	91.0	COG2318@1|root,COG2318@2|Bacteria,4NNW4@976|Bacteroidetes,1I28C@117743|Flavobacteriia	976|Bacteroidetes	J	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_2838097_1	1082931.KKY_1254	4.908e-108	367.0	COG3119@1|root,COG3119@2|Bacteria,1NTUU@1224|Proteobacteria,2UQWA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_2838097_0	234267.Acid_0334	5.743e-170	560.0	COG1305@1|root,COG1305@2|Bacteria,3Y5BT@57723|Acidobacteria	57723|Acidobacteria	E	Domain of unknown function (DUF3488)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,DUF4129,Transglut_core
TLS2_k127_2838097_2	926566.Terro_1338	1.061e-94	321.0	28K56@1|root,33QSK@2|Bacteria,3Y6TI@57723|Acidobacteria,2JKVS@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2838097_3	1123368.AUIS01000033_gene1379	4.496e-59	211.0	COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,1SBDJ@1236|Gammaproteobacteria,2NDBI@225057|Acidithiobacillales	225057|Acidithiobacillales	T	TspO/MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
TLS2_k127_2843425_0	290397.Adeh_2993	5.048e-171	552.0	COG0500@1|root,COG0500@2|Bacteria,1N3PV@1224|Proteobacteria	1224|Proteobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_2843425_1	1340493.JNIF01000003_gene2359	7.03e-69	246.0	COG2972@1|root,COG2972@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
TLS2_k127_2843425_2	1340493.JNIF01000003_gene2360	4.019e-51	191.0	COG3279@1|root,COG3279@2|Bacteria	2|Bacteria	KT	phosphorelay signal transduction system	coxC	GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007	-	ko:K02477,ko:K07705,ko:K21696	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022,ko03000	-	-	-	LytTR,MHYT,Response_reg
TLS2_k127_2843427_0	748247.AZKH_4141	7.596e-210	659.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2VJWJ@28216|Betaproteobacteria,2KUS2@206389|Rhodocyclales	206389|Rhodocyclales	U	type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	FHA,T2SSE
TLS2_k127_2843427_1	296591.Bpro_2556	4.83e-15	76.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2VJ80@28216|Betaproteobacteria,4A9JG@80864|Comamonadaceae	28216|Betaproteobacteria	U	Type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_2846626_4	1122604.JONR01000025_gene4602	5.17e-126	427.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS2_k127_2846626_5	641491.DND132_2314	2.173e-27	117.0	COG4273@1|root,COG4273@2|Bacteria,1MZED@1224|Proteobacteria,42UH2@68525|delta/epsilon subdivisions,2WQNQ@28221|Deltaproteobacteria,2MBB6@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	DGC domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DGC
TLS2_k127_2846626_0	13690.CP98_02547	8.409e-222	707.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TUXY@28211|Alphaproteobacteria,2K16Q@204457|Sphingomonadales	204457|Sphingomonadales	EU	peptidase S9	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_2846626_3	1267535.KB906767_gene4246	7.382e-182	580.0	COG3119@1|root,COG3119@2|Bacteria,3Y679@57723|Acidobacteria	57723|Acidobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,Sulfatase_C
TLS2_k127_2846626_2	1340493.JNIF01000003_gene3556	2.505e-203	647.0	COG3653@1|root,COG3653@2|Bacteria,3Y3Q2@57723|Acidobacteria	57723|Acidobacteria	Q	D-aminoacylase domain protein	-	-	3.5.1.81,3.5.2.3	ko:K01465,ko:K06015	ko00240,ko01100,map00240,map01100	M00051	R01993,R02192	RC00064,RC00328,RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
TLS2_k127_2846626_1	330214.NIDE0577	4.302e-209	659.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87
TLS2_k127_2854505_0	1123278.KB893574_gene6154	3.118e-214	685.0	COG2173@1|root,COG2173@2|Bacteria	2|Bacteria	M	zinc D-Ala-D-Ala carboxypeptidase activity	-	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15,SH3_3,SH3_4,VanY
TLS2_k127_2859664_2	452637.Oter_3160	4.783e-43	162.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2,SnoaL_4
TLS2_k127_2859664_3	452637.Oter_3159	6.336e-40	158.0	2FG05@1|root,347WV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2859664_1	452637.Oter_3158	9.552e-50	182.0	COG1595@1|root,COG1595@2|Bacteria,46W3R@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2859664_4	886293.Sinac_4353	1.422e-29	124.0	2A8GS@1|root,30XIR@2|Bacteria,2J2JC@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2859664_0	497964.CfE428DRAFT_3809	1.265e-61	222.0	COG0330@1|root,COG0330@2|Bacteria,46VZD@74201|Verrucomicrobia	74201|Verrucomicrobia	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_2859664_5	497964.CfE428DRAFT_3817	2.657e-26	115.0	COG1690@1|root,COG1690@2|Bacteria,46SU0@74201|Verrucomicrobia	74201|Verrucomicrobia	S	tRNA-splicing ligase RtcB	-	-	-	-	-	-	-	-	-	-	-	-	RtcB
TLS2_k127_2860270_2	1267535.KB906767_gene4183	1.196e-49	177.0	COG0552@1|root,COG0552@2|Bacteria,3Y3JQ@57723|Acidobacteria,2JIXJ@204432|Acidobacteriia	204432|Acidobacteriia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
TLS2_k127_2860270_0	1267535.KB906767_gene4184	1.577e-156	501.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,3Y2WU@57723|Acidobacteria,2JHYV@204432|Acidobacteriia	204432|Acidobacteriia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	-	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
TLS2_k127_2860270_1	234267.Acid_4223	1.476e-85	287.0	COG0307@1|root,COG0307@2|Bacteria,3Y4EE@57723|Acidobacteria	57723|Acidobacteria	H	riboflavin synthase, alpha subunit	-	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
TLS2_k127_2862276_1	234267.Acid_6539	3.289e-79	270.0	COG2930@1|root,COG2930@2|Bacteria,3Y2F0@57723|Acidobacteria	57723|Acidobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
TLS2_k127_2862276_0	1340493.JNIF01000003_gene2872	4.149e-264	827.0	COG1449@1|root,COG1449@2|Bacteria,3Y36M@57723|Acidobacteria	57723|Acidobacteria	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
TLS2_k127_2863943_3	1267535.KB906767_gene5226	7.156e-90	305.0	COG0475@1|root,COG0475@2|Bacteria	2|Bacteria	P	glutathione-regulated potassium exporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS2_k127_2863943_1	1340493.JNIF01000004_gene420	1.157e-112	375.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,Peptidase_M9,zf-ribbon_3
TLS2_k127_2863943_0	1340493.JNIF01000004_gene932	8.754e-141	463.0	COG3356@1|root,COG3356@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
TLS2_k127_2863943_2	234267.Acid_3244	2.238e-96	331.0	COG2133@1|root,COG2133@2|Bacteria,3Y7A7@57723|Acidobacteria	57723|Acidobacteria	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_2863943_4	1214101.BN159_1461	5.425e-09	66.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	attS	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Peptidase_S9
TLS2_k127_2864579_3	1127673.GLIP_3403	4.054e-09	70.0	COG2931@1|root,COG2931@2|Bacteria,1R0AV@1224|Proteobacteria,1T4G4@1236|Gammaproteobacteria,46C6H@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	Reprolysin (M12B) family zinc metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_5
TLS2_k127_2864579_4	700598.Niako_4604	1.11e-07	66.0	COG3266@1|root,COG3266@2|Bacteria,4PN6U@976|Bacteroidetes	976|Bacteroidetes	N	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_6,DUF4990
TLS2_k127_2864579_0	234267.Acid_0051	1.019e-79	271.0	COG0283@1|root,COG0283@2|Bacteria,3Y4MV@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
TLS2_k127_2864579_1	234267.Acid_0052	3.018e-39	152.0	COG0527@1|root,COG0527@2|Bacteria,3Y62M@57723|Acidobacteria	57723|Acidobacteria	E	Amino acid kinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,Homoserine_dh,NAD_binding_3
TLS2_k127_2865017_1	103733.JNYO01000060_gene8738	1.352e-47	181.0	COG1082@1|root,COG1082@2|Bacteria,2H1AC@201174|Actinobacteria	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_2865017_0	234267.Acid_3677	9.347e-91	312.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_2866171_0	1267535.KB906767_gene1167	1.374e-311	990.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_2866171_3	118166.JH976537_gene1884	4.286e-144	501.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG3437@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,1G09B@1117|Cyanobacteria,1H7T9@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
TLS2_k127_2866171_6	344747.PM8797T_13433	6.002e-32	130.0	2E13H@1|root,32WIX@2|Bacteria,2J0HQ@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2866171_2	756272.Plabr_0172	1.444e-147	481.0	COG3119@1|root,COG3119@2|Bacteria,2IX47@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.10.1.1	ko:K01565	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078	R07814	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
TLS2_k127_2866171_4	234267.Acid_1020	1.183e-78	269.0	COG1595@1|root,COG1595@2|Bacteria,3Y6DK@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2866171_7	234267.Acid_1021	3.827e-12	70.0	293BI@1|root,2ZQU6@2|Bacteria,3Y92V@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2866171_1	1267535.KB906767_gene560	3.211e-159	511.0	COG2223@1|root,COG2223@2|Bacteria,3Y6G1@57723|Acidobacteria,2JME7@204432|Acidobacteriia	204432|Acidobacteriia	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_2866332_7	639030.JHVA01000001_gene1886	1.292e-19	91.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_2866332_2	314230.DSM3645_11382	9.819e-193	613.0	COG3119@1|root,COG3119@2|Bacteria,2IX2H@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.14	ko:K01137	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078,M00079	R07808,R07819	-	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4976,Sulfatase
TLS2_k127_2866332_4	243090.RB5195	2.253e-139	458.0	COG3119@1|root,COG3119@2|Bacteria,2J1QG@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_2866332_3	1267535.KB906767_gene3728	1.836e-151	497.0	COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria,2JJYF@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS2_k127_2866332_0	1267535.KB906767_gene3578	1.665e-299	937.0	COG4262@1|root,COG4262@2|Bacteria,3Y6HM@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2866332_6	234267.Acid_7823	3.905e-126	412.0	COG2017@1|root,COG2017@2|Bacteria,3Y4YM@57723|Acidobacteria	57723|Acidobacteria	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2866332_5	1267535.KB906767_gene3194	6.063e-138	450.0	COG0151@1|root,COG0151@2|Bacteria,3Y6E1@57723|Acidobacteria,2JP3C@204432|Acidobacteriia	204432|Acidobacteriia	F	Phosphoribosylglycinamide synthetase, C domain	-	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
TLS2_k127_2866332_1	234267.Acid_0265	4.907e-215	683.0	COG3292@1|root,COG3292@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1906,VCBS
TLS2_k127_2866596_8	234267.Acid_6383	6.363e-66	231.0	COG0859@1|root,COG0859@2|Bacteria,3Y3EJ@57723|Acidobacteria	57723|Acidobacteria	M	PFAM glycosyl transferase family 9	-	-	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TLS2_k127_2866596_9	1267535.KB906767_gene442	5.268e-59	210.0	COG2020@1|root,COG2020@2|Bacteria,3Y4P4@57723|Acidobacteria,2JJJZ@204432|Acidobacteriia	204432|Acidobacteriia	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TLS2_k127_2866596_0	1267535.KB906767_gene3674	4.092e-192	607.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	MA20_02630	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_2866596_4	204669.Acid345_0003	2.022e-89	304.0	COG1940@1|root,COG1940@2|Bacteria,3Y6YN@57723|Acidobacteria,2JKMS@204432|Acidobacteriia	204432|Acidobacteriia	G	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_2866596_5	204669.Acid345_0004	7.866e-84	291.0	COG0449@1|root,COG0449@2|Bacteria	2|Bacteria	M	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	glmD	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
TLS2_k127_2866596_12	234267.Acid_6643	5.786e-27	120.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ANAPC5,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
TLS2_k127_2866596_14	1051985.l11_16830	5.22e-25	106.0	COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,2VW2V@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the UPF0337 (CsbD) family	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
TLS2_k127_2866596_1	1267535.KB906767_gene4459	3.529e-173	553.0	COG0673@1|root,COG0673@2|Bacteria,3Y2KV@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_2866596_11	639030.JHVA01000001_gene277	7.211e-51	184.0	COG2905@1|root,COG2905@2|Bacteria,3Y5NG@57723|Acidobacteria,2JN0N@204432|Acidobacteriia	204432|Acidobacteriia	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_2866596_3	234267.Acid_3356	8.462e-103	372.0	COG1629@1|root,COG4771@2|Bacteria,3Y2QR@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_2866596_2	234267.Acid_7201	2.461e-169	546.0	COG0612@1|root,COG0612@2|Bacteria,3Y3M9@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_2866596_7	234267.Acid_0973	9.406e-73	255.0	COG1512@1|root,COG1512@2|Bacteria,3Y4JT@57723|Acidobacteria	57723|Acidobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
TLS2_k127_2866596_6	1267535.KB906767_gene2794	1.899e-75	259.0	COG1708@1|root,COG1708@2|Bacteria,3Y7NX@57723|Acidobacteria,2JNB7@204432|Acidobacteriia	204432|Acidobacteriia	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2866596_10	1340493.JNIF01000003_gene2937	1.348e-52	190.0	COG1704@1|root,COG1704@2|Bacteria,3Y4QG@57723|Acidobacteria	57723|Acidobacteria	S	PFAM LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
TLS2_k127_2866776_3	1123389.ATXJ01000026_gene991	8.563e-21	94.0	COG1598@1|root,COG1598@2|Bacteria,1WKDA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2866776_0	234267.Acid_2231	5.185e-146	477.0	COG1473@1|root,COG1473@2|Bacteria	2|Bacteria	S	N-acetyldiaminopimelate deacetylase activity	abgB	-	-	ko:K12941	-	-	-	-	ko00000,ko01002	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_2866776_4	42565.FP66_05940	3.499e-08	62.0	COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1XKNI@135619|Oceanospirillales	135619|Oceanospirillales	S	colicin V production	cvpA	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
TLS2_k127_2866776_1	639030.JHVA01000001_gene29	1.047e-121	396.0	COG0152@1|root,COG0152@2|Bacteria,3Y2KX@57723|Acidobacteria,2JIG6@204432|Acidobacteriia	204432|Acidobacteriia	F	SAICAR synthetase	purC	-	6.3.2.6,6.3.4.13	ko:K01923,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
TLS2_k127_2866776_2	1267535.KB906767_gene4488	9.7e-48	191.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y695@57723|Acidobacteria	57723|Acidobacteria	KLTU	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
TLS2_k127_2870593_4	204669.Acid345_4287	4.127e-06	48.0	COG0242@1|root,COG0242@2|Bacteria,3Y4HY@57723|Acidobacteria,2JJ9D@204432|Acidobacteriia	204432|Acidobacteriia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TLS2_k127_2870593_1	234267.Acid_2747	2.7e-118	389.0	COG0223@1|root,COG0223@2|Bacteria,3Y32C@57723|Acidobacteria	57723|Acidobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TLS2_k127_2870593_0	234267.Acid_2748	2.662e-150	484.0	COG1364@1|root,COG1364@2|Bacteria,3Y2PH@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
TLS2_k127_2870593_5	401053.AciPR4_3566	5.823e-05	51.0	COG2318@1|root,COG2318@2|Bacteria,3Y4HD@57723|Acidobacteria,2JJ7B@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
TLS2_k127_2870593_3	1267535.KB906767_gene3960	7.333e-65	232.0	COG1215@1|root,COG2804@1|root,COG1215@2|Bacteria,COG2804@2|Bacteria,3Y6KA@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyl transferase family group 2	-	-	-	ko:K11740	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,T2SSE_N
TLS2_k127_2870593_2	234267.Acid_5606	1.616e-90	307.0	COG1215@1|root,COG1215@2|Bacteria,3Y6KA@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyl transferase family group 2	-	-	-	ko:K11740	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,T2SSE_N
TLS2_k127_2876549_4	234267.Acid_1761	2.68e-31	129.0	COG1355@1|root,COG1355@2|Bacteria,3Y5Z0@57723|Acidobacteria	57723|Acidobacteria	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
TLS2_k127_2876549_3	1267535.KB906767_gene2483	1.021e-45	173.0	COG1028@1|root,COG1028@2|Bacteria,3Y822@57723|Acidobacteria	57723|Acidobacteria	IQ	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_2876549_1	1267535.KB906767_gene2632	1.508e-150	488.0	COG1570@1|root,COG1570@2|Bacteria,3Y3DP@57723|Acidobacteria,2JIQN@204432|Acidobacteriia	204432|Acidobacteriia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TLS2_k127_2876549_0	243231.GSU3057	2.637e-178	570.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria,43UJI@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	nfnA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
TLS2_k127_2876549_2	194439.CT0474	1.043e-97	327.0	COG0543@1|root,COG0543@2|Bacteria,1FDJ4@1090|Chlorobi	1090|Chlorobi	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
TLS2_k127_2877330_6	1267535.KB906767_gene1513	9.573e-58	203.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	ko:K03535,ko:K08194	-	-	-	-	ko00000,ko02000	2.A.1.14.1,2.A.1.14.7	-	-	MFS_1,Sugar_tr
TLS2_k127_2877330_4	1267535.KB906767_gene1811	1.021e-75	261.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	ko:K03535,ko:K08194	-	-	-	-	ko00000,ko02000	2.A.1.14.1,2.A.1.14.7	-	-	MFS_1,Sugar_tr
TLS2_k127_2877330_1	234267.Acid_5431	0.0	1164.0	COG1629@1|root,COG4771@2|Bacteria,3Y2GB@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_2877330_0	234267.Acid_3358	0.0	1326.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_2877330_5	1089547.KB913013_gene114	2.671e-61	240.0	COG1629@1|root,COG4771@2|Bacteria,4NFZY@976|Bacteroidetes,47M16@768503|Cytophagia	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14.2	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
TLS2_k127_2877330_2	388413.ALPR1_19238	3.329e-149	479.0	2DBK2@1|root,2Z9Q1@2|Bacteria,4NET4@976|Bacteroidetes,47MUQ@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2877330_3	452637.Oter_2672	8.882e-103	348.0	COG2271@1|root,COG2271@2|Bacteria,46UQA@74201|Verrucomicrobia,3K8MQ@414999|Opitutae	414999|Opitutae	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_2877330_7	292459.STH1014	9.73e-29	121.0	COG0028@1|root,COG0028@2|Bacteria,1UYHG@1239|Firmicutes,24FP1@186801|Clostridia	186801|Clostridia	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_2877340_1	506534.Rhein_1259	6.775e-129	422.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RS1Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TLS2_k127_2877340_0	1216976.AX27061_0970	0.0	1177.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,3T1BB@506|Alcaligenaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_2878088_1	929712.KI912613_gene1849	7.3e-22	106.0	COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,2HFEI@201174|Actinobacteria,4CTJF@84995|Rubrobacteria	84995|Rubrobacteria	T	MEDS: MEthanogen/methylotroph, DcmR Sensory domain	-	-	-	-	-	-	-	-	-	-	-	-	MEDS
TLS2_k127_2878088_0	1267535.KB906767_gene5303	2.825e-86	293.0	COG0642@1|root,COG3829@1|root,COG4251@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE3,GAF,GGDEF,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_2878621_8	1340493.JNIF01000004_gene6	3.729e-11	71.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_2878621_7	1108045.GORHZ_109_00030	9.776e-13	70.0	2C62F@1|root,335K1@2|Bacteria,2GS5K@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2878621_9	909663.KI867150_gene2770	1.44e-10	71.0	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
TLS2_k127_2878621_3	1108045.GORHZ_109_00020	2.349e-41	159.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
TLS2_k127_2878621_5	909663.KI867150_gene2770	9.833e-22	96.0	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
TLS2_k127_2878621_2	234267.Acid_2804	2.151e-121	398.0	COG4299@1|root,COG4299@2|Bacteria,3Y2J9@57723|Acidobacteria	57723|Acidobacteria	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF5009
TLS2_k127_2878621_0	234267.Acid_3170	1.176e-177	565.0	COG0621@1|root,COG0621@2|Bacteria,3Y41R@57723|Acidobacteria	57723|Acidobacteria	J	Uncharacterized protein family UPF0004	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
TLS2_k127_2878621_1	234267.Acid_3971	1.578e-147	479.0	COG1252@1|root,COG1252@2|Bacteria,3Y308@57723|Acidobacteria	57723|Acidobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_2878621_4	1340493.JNIF01000003_gene4482	2.293e-22	108.0	COG0457@1|root,COG0457@2|Bacteria	1340493.JNIF01000003_gene4482|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2878621_6	234267.Acid_4740	1.925e-18	92.0	COG0745@1|root,COG0745@2|Bacteria	234267.Acid_4740|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2878621_10	1340493.JNIF01000003_gene1952	4.283e-08	54.0	COG0841@1|root,COG0841@2|Bacteria,3Y6DS@57723|Acidobacteria	57723|Acidobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran,OEP
TLS2_k127_2882612_0	1274524.BSONL12_21789	0.0	1062.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HV19@91061|Bacilli,1ZD1S@1386|Bacillus	91061|Bacilli	Q	Polyketide synthase of type I	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NAD_binding_4,PP-binding,PS-DH,ketoacyl-synt
TLS2_k127_2882612_1	1367847.JCM7686_1863	6.843e-51	190.0	COG3240@1|root,COG3240@2|Bacteria,1Q0NF@1224|Proteobacteria,2V8VJ@28211|Alphaproteobacteria,2PYB2@265|Paracoccus	28211|Alphaproteobacteria	I	lipase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2883906_0	1340493.JNIF01000003_gene2831	2.327e-190	604.0	COG0415@1|root,COG0415@2|Bacteria,3Y31R@57723|Acidobacteria	57723|Acidobacteria	L	PFAM DNA photolyase, FAD-binding	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
TLS2_k127_2883906_3	234267.Acid_6672	1.074e-90	308.0	COG1090@1|root,COG1090@2|Bacteria,3Y4IA@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
TLS2_k127_2883906_2	278957.ABEA03000165_gene4071	3.273e-101	345.0	COG0407@1|root,COG0407@2|Bacteria,46XYK@74201|Verrucomicrobia,3K8MR@414999|Opitutae	414999|Opitutae	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TLS2_k127_2883906_1	234267.Acid_1828	6.322e-115	398.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
TLS2_k127_2883906_4	234267.Acid_2874	4.673e-06	49.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
TLS2_k127_288456_1	234267.Acid_6791	4.776e-16	77.0	COG4974@1|root,COG4974@2|Bacteria,3Y73V@57723|Acidobacteria	57723|Acidobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_2885758_5	304371.MCP_2130	3.686e-06	51.0	COG0467@1|root,arCOG01174@2157|Archaea,2XV95@28890|Euryarchaeota,2N9UG@224756|Methanomicrobia	224756|Methanomicrobia	T	Pfam:KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
TLS2_k127_2885758_3	192952.MM_1091	8.044e-41	154.0	COG0526@1|root,arCOG07612@2157|Archaea,2Y43J@28890|Euryarchaeota,2NB18@224756|Methanomicrobia	224756|Methanomicrobia	O	KaiB	-	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	KaiB
TLS2_k127_2885758_6	1521187.JPIM01000057_gene2576	0.0002582	46.0	COG4251@1|root,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	kaiB	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	HATPase_c,KaiB,PAS_4,dCache_1
TLS2_k127_2885758_1	521011.Mpal_0994	2.157e-83	302.0	COG0526@1|root,COG0642@1|root,arCOG06712@1|root,arCOG02358@2157|Archaea,arCOG06712@2157|Archaea,arCOG07612@2157|Archaea,2Y7KG@28890|Euryarchaeota	28890|Euryarchaeota	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
TLS2_k127_2885758_2	1210884.HG799465_gene12237	2.118e-49	180.0	COG0662@1|root,COG0662@2|Bacteria,2J42S@203682|Planctomycetes	203682|Planctomycetes	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2885758_4	234267.Acid_7757	1.377e-31	128.0	COG1430@1|root,COG1430@2|Bacteria,3Y5J5@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
TLS2_k127_2885758_0	234267.Acid_3757	6.844e-162	532.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K03086,ko:K06867,ko:K06886	-	-	-	-	ko00000,ko03021	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
TLS2_k127_2886923_0	234267.Acid_6547	2.723e-257	812.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_2886923_1	234267.Acid_6548	1.462e-202	638.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_2886923_3	1340493.JNIF01000003_gene3976	2.486e-13	69.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_2886923_2	234267.Acid_7510	3.105e-133	450.0	COG1629@1|root,COG4771@2|Bacteria,3Y3KA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_2891972_0	234267.Acid_7944	1.731e-218	702.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria	234267.Acid_7944|-	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2891972_1	234267.Acid_7047	4.458e-95	325.0	2F7Z0@1|root,340CS@2|Bacteria,3Y88S@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2894221_2	1267535.KB906767_gene1896	1.486e-103	345.0	COG0296@1|root,COG2382@1|root,COG0296@2|Bacteria,COG2382@2|Bacteria,3Y2ZN@57723|Acidobacteria,2JP2N@204432|Acidobacteriia	204432|Acidobacteriia	GP	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase
TLS2_k127_2894221_4	204669.Acid345_4026	1.025e-51	197.0	COG0628@1|root,COG0628@2|Bacteria,3Y4A3@57723|Acidobacteria,2JJ4Y@204432|Acidobacteriia	204432|Acidobacteriia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_2894221_1	1267533.KB906738_gene2164	3.428e-133	429.0	COG0258@1|root,COG0258@2|Bacteria,3Y2FG@57723|Acidobacteria,2JME1@204432|Acidobacteriia	204432|Acidobacteriia	L	Helix-hairpin-helix class 2 (Pol1 family) motifs	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
TLS2_k127_2894221_5	1267535.KB906767_gene2393	4.577e-51	189.0	COG3127@1|root,COG3127@2|Bacteria,3Y7ZT@57723|Acidobacteria	57723|Acidobacteria	Q	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2894221_6	1267535.KB906767_gene2392	2.707e-36	140.0	COG1846@1|root,COG1846@2|Bacteria,3Y861@57723|Acidobacteria	57723|Acidobacteria	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
TLS2_k127_2894221_3	1187851.A33M_1873	1.067e-75	263.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2TTVJ@28211|Alphaproteobacteria,3FD0Q@34008|Rhodovulum	28211|Alphaproteobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS2_k127_2894221_8	1267535.KB906767_gene2789	1.204e-27	127.0	COG2823@1|root,COG2823@2|Bacteria,3Y7TR@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2894221_0	234267.Acid_3721	1.014e-149	484.0	COG3191@1|root,COG3191@2|Bacteria,3Y699@57723|Acidobacteria	57723|Acidobacteria	M	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
TLS2_k127_2894221_7	234267.Acid_4075	8.774e-35	138.0	COG4993@1|root,COG4993@2|Bacteria,3Y6WZ@57723|Acidobacteria	57723|Acidobacteria	C	Pyrrolo-quinoline quinone	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
TLS2_k127_2896220_1	518766.Rmar_0743	5.947e-133	434.0	COG0119@1|root,COG0119@2|Bacteria,4PFS6@976|Bacteroidetes,1FJX8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS2_k127_2896220_0	234267.Acid_0178	4.786e-175	556.0	COG0059@1|root,COG0059@2|Bacteria,3Y34M@57723|Acidobacteria	57723|Acidobacteria	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
TLS2_k127_2896220_2	1267535.KB906767_gene2415	7.817e-75	257.0	COG0440@1|root,COG0440@2|Bacteria,3Y580@57723|Acidobacteria	57723|Acidobacteria	E	Acetolactate synthase, small subunit	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
TLS2_k127_2896220_3	1340493.JNIF01000004_gene738	1.245e-66	228.0	COG0028@1|root,COG0028@2|Bacteria,3Y3GJ@57723|Acidobacteria	57723|Acidobacteria	EH	PFAM Thiamine pyrophosphate	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_2897147_0	234267.Acid_6513	9.073e-179	570.0	COG2895@1|root,COG2895@2|Bacteria,3Y3AW@57723|Acidobacteria	57723|Acidobacteria	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysN	-	2.7.7.4	ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_EFTU
TLS2_k127_2897147_1	234267.Acid_6512	4.681e-160	509.0	COG0175@1|root,COG0175@2|Bacteria,3Y36I@57723|Acidobacteria	57723|Acidobacteria	EH	TIGRFAM sulfate adenylyltransferase, small subunit	-	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TLS2_k127_2897147_2	234267.Acid_6511	2.636e-74	271.0	COG2234@1|root,COG2234@2|Bacteria,3Y3S9@57723|Acidobacteria	57723|Acidobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
TLS2_k127_2897492_2	634497.HAH_2123	2.57e-07	62.0	COG1331@1|root,arCOG02007@2157|Archaea	2157|Archaea	O	COG1331 Highly conserved protein containing a thioredoxin domain	-	-	3.2.1.180	ko:K18581	-	-	R10867	RC00049,RC02427	ko00000,ko01000	-	GH88	-	Glyco_hydro_88
TLS2_k127_2897492_0	234267.Acid_5778	3.583e-92	313.0	COG1295@1|root,COG1295@2|Bacteria,3Y7G1@57723|Acidobacteria	57723|Acidobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_2898168_5	682795.AciX8_3234	2.346e-42	157.0	COG1415@1|root,COG1415@2|Bacteria,3Y6D2@57723|Acidobacteria,2JKZS@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
TLS2_k127_2898168_6	1267535.KB906767_gene5362	3.094e-36	145.0	COG0526@1|root,COG0526@2|Bacteria,3Y8DU@57723|Acidobacteria	57723|Acidobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_2898168_7	1340493.JNIF01000003_gene4478	3.082e-27	118.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	AhpC-TSA,Redoxin,Thioredoxin
TLS2_k127_2898168_3	234267.Acid_1474	2.479e-102	346.0	COG2856@1|root,COG2856@2|Bacteria	2|Bacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2898168_0	1340493.JNIF01000004_gene416	4.904e-207	651.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	gudD	-	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_2898168_4	288000.BBta_3868	1.668e-50	188.0	COG1876@1|root,COG3926@1|root,COG1876@2|Bacteria,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,2TT3H@28211|Alphaproteobacteria,3K0NK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Predicted Peptidoglycan domain	-	-	-	ko:K17733	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Glyco_hydro_108,PG_binding_1,PG_binding_3,VanY
TLS2_k127_2898168_1	234267.Acid_1510	1.674e-143	476.0	COG3485@1|root,COG3485@2|Bacteria,3Y44E@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_2898168_2	1340493.JNIF01000003_gene4121	6.069e-134	434.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2900302_2	234267.Acid_5042	1.126e-70	242.0	COG0041@1|root,COG0041@2|Bacteria,3Y4MB@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
TLS2_k127_2900302_0	1340493.JNIF01000003_gene3787	3.346e-216	680.0	COG0473@1|root,COG0473@2|Bacteria	2|Bacteria	CE	3-isopropylmalate dehydrogenase activity	icd	-	1.1.1.41,1.1.1.42	ko:K00030,ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R00709,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_2900302_1	1267535.KB906767_gene1277	1.249e-116	382.0	COG0109@1|root,COG0109@2|Bacteria,3Y3VI@57723|Acidobacteria,2JIRB@204432|Acidobacteriia	204432|Acidobacteriia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
TLS2_k127_2900302_3	1267535.KB906767_gene1278	1.045e-12	72.0	COG1999@1|root,COG1999@2|Bacteria,3Y855@57723|Acidobacteria	57723|Acidobacteria	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
TLS2_k127_2905791_1	234267.Acid_2029	2.176e-192	601.0	COG1158@1|root,COG1158@2|Bacteria,3Y2V3@57723|Acidobacteria	57723|Acidobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
TLS2_k127_2905791_2	1267535.KB906767_gene4999	1.508e-115	383.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Calx-beta,CarboxypepD_reg,DUF1080,F5_F8_type_C,G5,G8,Glyco_hyd_101C,Glyco_hydro_101,Trypsin_2,YSIRK_signal,fn3
TLS2_k127_2905791_3	234267.Acid_5130	3.295e-75	261.0	COG0491@1|root,COG0491@2|Bacteria,3Y44S@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
TLS2_k127_2905791_0	234267.Acid_1653	1.12e-202	640.0	COG0372@1|root,COG0372@2|Bacteria,3Y32J@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS2_k127_2914345_0	234267.Acid_3106	2.191e-309	961.0	28HBM@1|root,2Z7NK@2|Bacteria,3Y6H0@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2914345_1	234267.Acid_3344	3.964e-91	309.0	COG0684@1|root,COG0684@2|Bacteria,3Y7HG@57723|Acidobacteria	57723|Acidobacteria	M	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
TLS2_k127_2920000_0	670307.HYPDE_29688	3.318e-100	339.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG0840@1|root,COG2770@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG0840@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1QUJ7@1224|Proteobacteria,2TXCB@28211|Alphaproteobacteria,3N8FB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Response_reg
TLS2_k127_2920000_1	1300345.LF41_1550	7.509e-34	135.0	COG0642@1|root,COG0784@1|root,COG2199@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,1RQ3H@1236|Gammaproteobacteria,1X3SI@135614|Xanthomonadales	135614|Xanthomonadales	T	two-component system sensor protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
TLS2_k127_2922639_1	204669.Acid345_0730	1.022e-77	263.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,3Y415@57723|Acidobacteria,2JM30@204432|Acidobacteriia	204432|Acidobacteriia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,PFOR_II,POR,POR_N,TPP_enzyme_C
TLS2_k127_2922639_0	204669.Acid345_0729	5.281e-128	419.0	COG0167@1|root,COG0167@2|Bacteria,3Y464@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TLS2_k127_2922639_3	234267.Acid_4979	1.137e-15	83.0	COG3584@1|root,COG3584@2|Bacteria,3Y8W5@57723|Acidobacteria	57723|Acidobacteria	S	3D domain	-	-	-	-	-	-	-	-	-	-	-	-	3D
TLS2_k127_2922639_2	861299.J421_2192	2.377e-21	97.0	28PTG@1|root,2ZCEQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2922772_4	234267.Acid_3128	1.225e-28	122.0	COG3942@1|root,COG3942@2|Bacteria	2|Bacteria	S	pathogenesis	gsp	-	3.5.1.78,6.3.1.8	ko:K01460	ko00480,ko01100,map00480,map01100	-	R01917,R01918	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	Big_2,CHAP,GBS_Bsp-like,GSP_synth
TLS2_k127_2922772_2	234267.Acid_0194	2.58e-88	322.0	COG1629@1|root,COG4771@2|Bacteria,3Y7GJ@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_2922772_3	1340493.JNIF01000003_gene3457	1.272e-39	157.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	TonB_dep_Rec
TLS2_k127_2922772_0	243090.RB941	3.466e-140	468.0	COG0644@1|root,COG0644@2|Bacteria,2IYCM@203682|Planctomycetes	203682|Planctomycetes	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_2922772_1	742726.HMPREF9448_01738	1.225e-107	366.0	COG1053@1|root,COG1053@2|Bacteria,4NG56@976|Bacteroidetes,2FNK8@200643|Bacteroidia,22YF8@171551|Porphyromonadaceae	976|Bacteroidetes	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_2933689_0	1267534.KB906760_gene1328	1.929e-51	195.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y67D@57723|Acidobacteria,2JM70@204432|Acidobacteriia	204432|Acidobacteriia	T	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2933689_2	234267.Acid_0951	4.285e-18	93.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_0951|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2933689_1	1095769.CAHF01000022_gene253	4.902e-33	141.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_2936963_0	1267534.KB906760_gene1328	2.701e-86	308.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y67D@57723|Acidobacteria,2JM70@204432|Acidobacteriia	204432|Acidobacteriia	T	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2936963_2	36651.K9G422	5.868e-08	58.0	COG1454@1|root,KOG3857@2759|Eukaryota,38EFC@33154|Opisthokonta,3NV05@4751|Fungi,3QKDR@4890|Ascomycota,20BJA@147545|Eurotiomycetes,3S6XW@5042|Eurotiales	4751|Fungi	C	Fe-containing alcohol dehydrogenase	-	-	1.1.99.24	ko:K11173	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
TLS2_k127_2936963_1	234267.Acid_1019	7.606e-27	115.0	COG1089@1|root,COG1089@2|Bacteria,3Y3QZ@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_2938815_3	234267.Acid_6432	2.734e-80	276.0	COG0497@1|root,COG3266@1|root,COG0497@2|Bacteria,COG3266@2|Bacteria,3Y6KC@57723|Acidobacteria	57723|Acidobacteria	L	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2938815_0	234267.Acid_6433	1.442e-177	578.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
TLS2_k127_2938815_2	234267.Acid_6434	9.106e-127	411.0	COG1721@1|root,COG1721@2|Bacteria,3Y5XW@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_2938815_1	234267.Acid_6435	4.282e-166	529.0	COG0714@1|root,COG0714@2|Bacteria,3Y3BH@57723|Acidobacteria	57723|Acidobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_2938815_4	926566.Terro_0571	3.876e-06	52.0	COG0308@1|root,COG0457@1|root,COG0308@2|Bacteria,COG0457@2|Bacteria,3Y6C4@57723|Acidobacteria,2JM8A@204432|Acidobacteriia	204432|Acidobacteriia	E	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2939944_3	1157708.KB907450_gene6417	9.066e-14	75.0	COG4977@1|root,COG4977@2|Bacteria,1QUTN@1224|Proteobacteria,2VVGP@28216|Betaproteobacteria,4AJ5F@80864|Comamonadaceae	28216|Betaproteobacteria	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
TLS2_k127_2939944_2	1051646.VITU9109_22666	2.605e-28	120.0	COG0637@1|root,COG0637@2|Bacteria,1R8Z3@1224|Proteobacteria,1S4ZI@1236|Gammaproteobacteria,1XT2Y@135623|Vibrionales	135623|Vibrionales	S	phosphatase phosphohexomutase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS2_k127_2939944_1	1265502.KB905955_gene455	9.087e-33	129.0	2DP2V@1|root,330AH@2|Bacteria,1RAH8@1224|Proteobacteria,2VQNV@28216|Betaproteobacteria,4ADGB@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3455
TLS2_k127_2943873_0	198467.NP92_13155	3.007e-149	488.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,21VG5@150247|Anoxybacillus	91061|Bacilli	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_2943873_4	717605.Theco_0518	6.261e-08	64.0	COG3717@1|root,COG3717@2|Bacteria,1TP4X@1239|Firmicutes,4HBJH@91061|Bacilli,26R50@186822|Paenibacillaceae	91061|Bacilli	G	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate	kduI	-	5.3.1.17	ko:K01815	ko00040,map00040	-	R04383	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
TLS2_k127_2943873_3	1382359.JIAL01000001_gene2011	1.656e-20	96.0	2EC48@1|root,33633@2|Bacteria,3Y5ER@57723|Acidobacteria,2JJVN@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2943873_1	909663.KI867150_gene1774	6.757e-80	273.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,42T9X@68525|delta/epsilon subdivisions,2WP59@28221|Deltaproteobacteria,2MQNB@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_2943873_2	234267.Acid_0380	5.366e-79	269.0	COG1502@1|root,COG1502@2|Bacteria,3Y2GD@57723|Acidobacteria	57723|Acidobacteria	I	PLD-like domain	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
TLS2_k127_2948334_0	1340493.JNIF01000003_gene4471	1.522e-136	446.0	COG2304@1|root,COG2304@2|Bacteria,3Y5S3@57723|Acidobacteria	57723|Acidobacteria	S	Vault protein inter-alpha-trypsin domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
TLS2_k127_2948334_1	1267535.KB906767_gene2640	6.548e-106	353.0	COG1085@1|root,COG1085@2|Bacteria,3Y3TR@57723|Acidobacteria,2JI7V@204432|Acidobacteriia	204432|Acidobacteriia	C	Galactose-1-phosphate uridyl transferase, C-terminal domain	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
TLS2_k127_2955780_0	234267.Acid_4982	1.353e-181	580.0	COG0318@1|root,COG0318@2|Bacteria,3Y68M@57723|Acidobacteria	57723|Acidobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_2955780_4	234267.Acid_4273	1.829e-36	154.0	COG3324@1|root,COG3324@2|Bacteria	2|Bacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_2955780_3	404589.Anae109_0545	1.876e-90	308.0	COG1612@1|root,COG1612@2|Bacteria,1PV6F@1224|Proteobacteria,4303Y@68525|delta/epsilon subdivisions,2WVAK@28221|Deltaproteobacteria,2YUJ2@29|Myxococcales	28221|Deltaproteobacteria	O	cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
TLS2_k127_2955780_5	1267535.KB906767_gene4633	8.953e-10	68.0	2EQJB@1|root,33I5C@2|Bacteria,3Y5WN@57723|Acidobacteria,2JNK1@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2955780_2	1267533.KB906740_gene290	6.152e-98	346.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria	57723|Acidobacteria	KU	WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_2955780_1	1267535.KB906767_gene5141	4.112e-99	349.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria	57723|Acidobacteria	KU	WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_2955780_6	102129.Lepto7375DRAFT_6917	0.0008684	44.0	COG0457@1|root,COG0457@2|Bacteria,1G1QI@1117|Cyanobacteria,1H6XA@1150|Oscillatoriales	1117|Cyanobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,TPR_12,TPR_7
TLS2_k127_2972388_0	1267535.KB906767_gene3683	1.043e-188	608.0	COG1529@1|root,COG1529@2|Bacteria,3Y3J7@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_2972388_1	234267.Acid_3355	8.404e-86	296.0	COG4251@1|root,COG4251@2|Bacteria,3Y72P@57723|Acidobacteria	57723|Acidobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_2,PAS_4,PHY
TLS2_k127_2972388_2	1267535.KB906767_gene190	1.175e-46	176.0	COG3571@1|root,COG3571@2|Bacteria,3Y7N8@57723|Acidobacteria	57723|Acidobacteria	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	Abhydrolase_5,Abhydrolase_6
TLS2_k127_2974365_0	234267.Acid_0457	2.575e-140	453.0	COG0348@1|root,COG0348@2|Bacteria,3Y3H4@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
TLS2_k127_2974365_1	234267.Acid_1287	2.213e-107	359.0	COG0810@1|root,COG0810@2|Bacteria,3Y5QN@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family protein	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TLS2_k127_2974365_3	316067.Geob_1640	4.357e-61	216.0	COG3861@1|root,COG3861@2|Bacteria,1QYWN@1224|Proteobacteria,43E8W@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
TLS2_k127_2974365_2	1267535.KB906767_gene897	1.244e-79	273.0	COG5002@1|root,COG5002@2|Bacteria,3Y99C@57723|Acidobacteria,2JP5N@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_2989949_0	234267.Acid_4756	0.0	1147.0	COG0013@1|root,COG0013@2|Bacteria,3Y359@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS2_k127_2989949_1	1267535.KB906767_gene5293	3.856e-153	489.0	COG0492@1|root,COG0492@2|Bacteria,3Y2NX@57723|Acidobacteria	57723|Acidobacteria	O	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_3
TLS2_k127_2989949_2	506534.Rhein_1952	1.637e-27	122.0	COG2076@1|root,COG2076@2|Bacteria,1MZ6P@1224|Proteobacteria,1S8TD@1236|Gammaproteobacteria,1WYQ8@135613|Chromatiales	135613|Chromatiales	U	PFAM small multidrug resistance protein	-	-	-	ko:K11741	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
TLS2_k127_2995230_5	234267.Acid_0894	3.909e-41	155.0	COG1567@1|root,COG1567@2|Bacteria,3Y72B@57723|Acidobacteria	57723|Acidobacteria	L	CRISPR-associated RAMP protein, Csm4 family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2995230_1	1267535.KB906767_gene2608	5.331e-132	425.0	COG1337@1|root,COG1337@2|Bacteria,3Y6QK@57723|Acidobacteria	57723|Acidobacteria	L	RAMP superfamily	-	-	-	ko:K09002	-	-	-	-	ko00000,ko02048	-	-	-	RAMPs
TLS2_k127_2995230_4	1340493.JNIF01000003_gene4417	6.603e-61	216.0	COG1421@1|root,COG1421@2|Bacteria	2|Bacteria	L	Csm2 Type III-A	csm2	-	-	ko:K19138	-	-	-	-	ko00000,ko02048	-	-	-	Csm2_III-A
TLS2_k127_2995230_2	234267.Acid_0891	2.153e-121	405.0	COG1353@1|root,COG1353@2|Bacteria,3Y6EG@57723|Acidobacteria	57723|Acidobacteria	S	crispr-associated protein	-	-	-	ko:K07016	-	-	-	-	ko00000,ko02048	-	-	-	-
TLS2_k127_2995230_3	234267.Acid_7197	8.081e-102	339.0	COG1028@1|root,COG1028@2|Bacteria,3Y6TA@57723|Acidobacteria	57723|Acidobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_2995230_0	639030.JHVA01000001_gene841	9.348e-182	595.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,3Y3GW@57723|Acidobacteria,2JHKK@204432|Acidobacteriia	204432|Acidobacteriia	I	Phosphate acyltransferases	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
TLS2_k127_2995855_1	365044.Pnap_1202	2.105e-182	589.0	COG1404@1|root,COG1404@2|Bacteria,1QVJR@1224|Proteobacteria	1224|Proteobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS2_k127_2995855_0	204669.Acid345_1273	6.992e-192	606.0	COG1690@1|root,COG1690@2|Bacteria,3Y82C@57723|Acidobacteria,2JN64@204432|Acidobacteriia	204432|Acidobacteriia	S	tRNA-splicing ligase RtcB	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
TLS2_k127_300002_0	234267.Acid_5115	2.415e-112	366.0	COG0090@1|root,COG0090@2|Bacteria,3Y3DH@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
TLS2_k127_300002_4	1267535.KB906767_gene2702	4.593e-36	141.0	COG0089@1|root,COG0089@2|Bacteria,3Y58W@57723|Acidobacteria	57723|Acidobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
TLS2_k127_300002_2	1267535.KB906767_gene2703	7.52e-87	292.0	COG0088@1|root,COG0088@2|Bacteria,3Y2PM@57723|Acidobacteria,2JIZE@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
TLS2_k127_300002_1	234267.Acid_5118	4.149e-106	347.0	COG0087@1|root,COG0087@2|Bacteria,3Y2H7@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
TLS2_k127_300002_3	1340493.JNIF01000003_gene3206	1.142e-54	193.0	COG0051@1|root,COG0051@2|Bacteria,3Y4V5@57723|Acidobacteria	57723|Acidobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
TLS2_k127_300002_5	1340493.JNIF01000003_gene3205	6.531e-24	100.0	COG0050@1|root,COG0050@2|Bacteria,3Y2JG@57723|Acidobacteria	57723|Acidobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TLS2_k127_3003840_2	1267535.KB906767_gene569	2.528e-59	226.0	COG3829@1|root,COG4251@1|root,COG3829@2|Bacteria,COG4251@2|Bacteria,3Y99J@57723|Acidobacteria,2JKK0@204432|Acidobacteriia	204432|Acidobacteriia	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
TLS2_k127_3003840_4	1340493.JNIF01000003_gene4593	3.379e-32	143.0	COG2199@1|root,COG2203@1|root,COG3437@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,3Y9F7@57723|Acidobacteria	57723|Acidobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
TLS2_k127_3003840_1	1198114.AciX9_2897	1.282e-109	375.0	COG1404@1|root,COG5164@1|root,COG1404@2|Bacteria,COG5164@2|Bacteria,3Y5WB@57723|Acidobacteria,2JK6I@204432|Acidobacteriia	204432|Acidobacteriia	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS2_k127_3003840_0	1198114.AciX9_2897	1.049e-130	439.0	COG1404@1|root,COG5164@1|root,COG1404@2|Bacteria,COG5164@2|Bacteria,3Y5WB@57723|Acidobacteria,2JK6I@204432|Acidobacteriia	204432|Acidobacteriia	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS2_k127_3003840_3	1157635.KB892035_gene6201	2.322e-58	213.0	COG0444@1|root,COG1173@1|root,COG0444@2|Bacteria,COG1173@2|Bacteria,2GIXV@201174|Actinobacteria	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,BPD_transp_1,OppC_N,oligo_HPY
TLS2_k127_3008836_1	1340493.JNIF01000003_gene2701	3.462e-146	469.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3IB@57723|Acidobacteria	2|Bacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_3008836_0	234267.Acid_1498	6.989e-160	514.0	COG1030@1|root,COG1030@2|Bacteria,3Y31N@57723|Acidobacteria	57723|Acidobacteria	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
TLS2_k127_3008836_2	234267.Acid_1499	2.664e-118	385.0	COG0330@1|root,COG0330@2|Bacteria,3Y33E@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_3008836_3	1121904.ARBP01000002_gene6684	8.068e-05	48.0	COG2382@1|root,COG3525@1|root,COG2382@2|Bacteria,COG3525@2|Bacteria,4NE08@976|Bacteroidetes,47K79@768503|Cytophagia	976|Bacteroidetes	G	PFAM Glycoside hydrolase, family 20, catalytic core	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	CBM9_1,Glyco_hydro_20,Glyco_hydro_20b,Glycohydro_20b2
TLS2_k127_3022733_0	156889.Mmc1_2548	3.766e-130	424.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,2U24Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
TLS2_k127_3023239_4	1267535.KB906767_gene880	2.226e-121	401.0	COG0612@1|root,COG0612@2|Bacteria,3Y2FB@57723|Acidobacteria,2JHWY@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16_C
TLS2_k127_3023239_3	1267535.KB906767_gene879	1.267e-166	537.0	COG0612@1|root,COG0612@2|Bacteria,3Y3XF@57723|Acidobacteria,2JHR4@204432|Acidobacteriia	204432|Acidobacteriia	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_3023239_0	1267535.KB906767_gene717	0.0	1745.0	COG0458@1|root,COG0458@2|Bacteria,3Y3GG@57723|Acidobacteria,2JIJZ@204432|Acidobacteriia	204432|Acidobacteriia	F	TIGRFAM carbamoyl-phosphate synthase, large subunit	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS2_k127_3023239_2	234267.Acid_2394	5.008e-184	582.0	COG0505@1|root,COG0505@2|Bacteria,3Y31Y@57723|Acidobacteria	57723|Acidobacteria	EF	TIGRFAM Carbamoyl-phosphate synthase, small subunit	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
TLS2_k127_3023239_1	234267.Acid_6938	1.204e-204	646.0	COG5368@1|root,COG5368@2|Bacteria,3Y2MM@57723|Acidobacteria	57723|Acidobacteria	S	Putative glucoamylase	-	-	-	-	-	-	-	-	-	-	-	-	Glycoamylase
TLS2_k127_3023239_5	234267.Acid_6937	4.116e-86	299.0	2EZWR@1|root,33T12@2|Bacteria,3Y6BD@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3024992_3	401526.TcarDRAFT_2289	5.127e-05	46.0	2AV93@1|root,31M00@2|Bacteria,1V94N@1239|Firmicutes,4H7KF@909932|Negativicutes	909932|Negativicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3024992_0	234267.Acid_5363	9.631e-151	485.0	COG0232@1|root,COG0232@2|Bacteria,3Y2S2@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the dGTPase family. Type 2 subfamily	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
TLS2_k127_3024992_1	234267.Acid_5362	1.162e-38	153.0	COG2976@1|root,COG2976@2|Bacteria,3Y9AW@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
TLS2_k127_3024992_2	234267.Acid_3656	2.091e-36	143.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
TLS2_k127_3032250_5	864069.MicloDRAFT_00056850	2.99e-56	202.0	COG4641@1|root,COG4641@2|Bacteria,1MUW9@1224|Proteobacteria,2TTZM@28211|Alphaproteobacteria,1JR4I@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
TLS2_k127_3032250_4	1123368.AUIS01000005_gene436	1.701e-59	211.0	COG0406@1|root,COG0406@2|Bacteria,1N5BK@1224|Proteobacteria,1T885@1236|Gammaproteobacteria,2NCFA@225057|Acidithiobacillales	225057|Acidithiobacillales	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
TLS2_k127_3032250_7	234267.Acid_0742	2.285e-36	151.0	2E36Z@1|root,32Y6R@2|Bacteria,3Y5W9@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3032250_6	1121033.AUCF01000014_gene1347	1.242e-38	158.0	COG3685@1|root,COG3685@2|Bacteria,1REKN@1224|Proteobacteria,2U73U@28211|Alphaproteobacteria,2JWRW@204441|Rhodospirillales	204441|Rhodospirillales	S	Domain of unknown function (DUF892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF892
TLS2_k127_3032250_2	234267.Acid_1756	3.234e-124	406.0	COG1378@1|root,COG1378@2|Bacteria,3Y66F@57723|Acidobacteria	57723|Acidobacteria	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
TLS2_k127_3032250_3	1340493.JNIF01000004_gene222	2.341e-84	290.0	COG0667@1|root,COG0667@2|Bacteria,3Y3TE@57723|Acidobacteria	2|Bacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_3032250_1	1340493.JNIF01000004_gene818	1.242e-228	715.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_3032250_0	1340493.JNIF01000004_gene819	5.891e-287	897.0	COG4654@1|root,COG4654@2|Bacteria	2|Bacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_3032287_3	221288.JH992901_gene3403	4.296e-38	147.0	COG3540@1|root,COG3540@2|Bacteria,1G0C9@1117|Cyanobacteria,1JKIQ@1189|Stigonemataceae	1117|Cyanobacteria	P	PhoD-like phosphatase, N-terminal domain	phoD	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
TLS2_k127_3032287_1	1267535.KB906767_gene4894	1.288e-230	723.0	COG2721@1|root,COG2721@2|Bacteria,3Y722@57723|Acidobacteria	57723|Acidobacteria	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	-	-	4.2.1.42	ko:K01708	ko00053,map00053	-	R05608	RC00543	ko00000,ko00001,ko01000	-	-	-	GD_AH_C,SAF
TLS2_k127_3032287_2	614083.AWQR01000056_gene3581	8.67e-50	187.0	COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2VSZ8@28216|Betaproteobacteria,4ADFB@80864|Comamonadaceae	28216|Betaproteobacteria	M	Beta-Ig-H3 fasciclin	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
TLS2_k127_3032287_0	234267.Acid_0848	8.766e-261	813.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,3Y2SH@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase X	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
TLS2_k127_3037981_2	234267.Acid_2315	4.474e-62	219.0	COG2120@1|root,COG2120@2|Bacteria,3Y3BV@57723|Acidobacteria	57723|Acidobacteria	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_3037981_3	204669.Acid345_3764	2.764e-61	216.0	COG2193@1|root,COG2193@2|Bacteria,3Y56Z@57723|Acidobacteria,2JMWM@204432|Acidobacteriia	204432|Acidobacteriia	C	Ferritin-like domain	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TLS2_k127_3037981_0	1267535.KB906767_gene838	4.605e-220	702.0	COG2204@1|root,COG2204@2|Bacteria,3Y3HH@57723|Acidobacteria,2JI5D@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_3037981_1	234267.Acid_7431	2.36e-100	349.0	COG3852@1|root,COG3852@2|Bacteria,3Y9B5@57723|Acidobacteria	57723|Acidobacteria	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_3037981_4	1123508.JH636445_gene6495	7.596e-36	136.0	COG0607@1|root,COG0607@2|Bacteria,2IZWR@203682|Planctomycetes	203682|Planctomycetes	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_3040056_1	1242864.D187_001468	3.48e-95	331.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,437VX@68525|delta/epsilon subdivisions,2X35F@28221|Deltaproteobacteria,2YUCR@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_3040056_0	1267535.KB906767_gene1147	1.72e-159	535.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
TLS2_k127_3053774_8	1267535.KB906767_gene4338	3.195e-50	180.0	COG0178@1|root,COG0178@2|Bacteria,3Y3G9@57723|Acidobacteria,2JI80@204432|Acidobacteriia	204432|Acidobacteriia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_3053774_7	492774.JQMB01000001_gene5799	4.438e-61	222.0	COG1262@1|root,COG1262@2|Bacteria,1PG3S@1224|Proteobacteria,2V7ID@28211|Alphaproteobacteria,4B8IJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase
TLS2_k127_3053774_0	1340493.JNIF01000003_gene4273	0.0	1056.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt3,PSD2,PSD3,PSD4,PSD5
TLS2_k127_3053774_1	234267.Acid_4306	2.337e-228	714.0	COG2960@1|root,COG2960@2|Bacteria,3Y7EA@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
TLS2_k127_3053774_5	234267.Acid_4308	1.638e-94	321.0	COG1957@1|root,COG1957@2|Bacteria	2|Bacteria	F	ribosylpyrimidine nucleosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,IU_nuc_hydro
TLS2_k127_3053774_9	243090.RB621	3.703e-32	132.0	COG1595@1|root,COG1595@2|Bacteria,2IZ8A@203682|Planctomycetes	203682|Planctomycetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_3053774_6	1287276.X752_11730	1.387e-72	256.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,2TU80@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	methyltransferase activity	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU,PEMT
TLS2_k127_3053774_4	234267.Acid_2543	6.533e-130	427.0	COG1503@1|root,COG1503@2|Bacteria,3Y6P2@57723|Acidobacteria	57723|Acidobacteria	J	eRF1 domain 3	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach,eRF1_3
TLS2_k127_3053774_3	1340493.JNIF01000003_gene3849	2.423e-134	436.0	COG2304@1|root,COG2304@2|Bacteria,3Y6QE@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
TLS2_k127_3053774_2	1267535.KB906767_gene74	1.488e-145	470.0	COG1032@1|root,COG1032@2|Bacteria,3Y7DR@57723|Acidobacteria	57723|Acidobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_3054217_1	1161401.ASJA01000007_gene2138	2.467e-83	288.0	COG2267@1|root,COG2267@2|Bacteria,1NIJG@1224|Proteobacteria,2U09P@28211|Alphaproteobacteria,43XBT@69657|Hyphomonadaceae	28211|Alphaproteobacteria	IK	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,BTAD,Guanylate_cyc,Hydrolase_4,Trans_reg_C
TLS2_k127_3054217_0	251221.35211765	2.177e-188	617.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_3054217_2	1340493.JNIF01000003_gene3565	1.425e-06	55.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_305506_4	543728.Vapar_2768	1.77e-80	273.0	COG0010@1|root,COG0010@2|Bacteria,1R8G3@1224|Proteobacteria,2W1GC@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS2_k127_305506_2	936136.ARRT01000006_gene2878	5.843e-128	417.0	COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,2TSK5@28211|Alphaproteobacteria,4BIJ6@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_305506_1	1333856.L686_08990	7.27e-254	792.0	COG1626@1|root,COG1626@2|Bacteria,1MWSM@1224|Proteobacteria,1RMFP@1236|Gammaproteobacteria,1Z0GD@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	G	Trehalase	treF	GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009628,GO:0009987,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0033554,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0050896,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071704,GO:0104004,GO:1901575	3.2.1.28	ko:K01194	ko00500,ko01100,map00500,map01100	-	R00010	RC00049	ko00000,ko00001,ko00537,ko01000	-	GH37	iSBO_1134.SBO_3518	Trehalase
TLS2_k127_305506_6	1133849.O3I_007615	3.172e-42	162.0	COG4319@1|root,COG4319@2|Bacteria,2II1S@201174|Actinobacteria,4G18S@85025|Nocardiaceae	201174|Actinobacteria	E	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
TLS2_k127_305506_0	401053.AciPR4_2656	2.593e-282	887.0	COG3669@1|root,COG3669@2|Bacteria,3Y37T@57723|Acidobacteria,2JKVF@204432|Acidobacteriia	204432|Acidobacteriia	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,F5_F8_type_C
TLS2_k127_305506_5	288000.BBta_6198	4.676e-50	193.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TSUC@28211|Alphaproteobacteria,3JVGG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_305506_3	398525.KB900701_gene5667	5.771e-85	287.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,3JRQF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_3057668_1	886293.Sinac_1008	3.416e-63	227.0	COG0673@1|root,COG0673@2|Bacteria,2IX39@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_3057668_0	204669.Acid345_0638	9.395e-162	545.0	COG1629@1|root,COG4771@2|Bacteria,3Y3HY@57723|Acidobacteria,2JIYZ@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_3057668_2	1267535.KB906767_gene4363	1.591e-44	185.0	COG0383@1|root,COG0383@2|Bacteria,3Y77D@57723|Acidobacteria,2JKQ2@204432|Acidobacteriia	204432|Acidobacteriia	G	Polysaccharide lyase family 4, domain III	-	-	-	-	-	-	-	-	-	-	-	-	CBM-like,Glyco_hydro_38,Glyco_hydro_38C
TLS2_k127_3058489_0	1267535.KB906767_gene2230	3.328e-244	794.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_3058489_4	1267535.KB906767_gene2672	2.444e-54	195.0	COG1610@1|root,COG1610@2|Bacteria,3Y4VF@57723|Acidobacteria,2JJJH@204432|Acidobacteriia	204432|Acidobacteriia	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS2_k127_3058489_2	234267.Acid_1660	4.476e-172	552.0	COG0075@1|root,COG0075@2|Bacteria,3Y3I6@57723|Acidobacteria	57723|Acidobacteria	E	aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_3058489_1	1267535.KB906767_gene4074	5.226e-217	685.0	COG0111@1|root,COG0111@2|Bacteria,3Y7TQ@57723|Acidobacteria,2JP70@204432|Acidobacteriia	204432|Acidobacteriia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_3058489_3	1267535.KB906767_gene4175	2.474e-150	484.0	COG0787@1|root,COG0787@2|Bacteria,3Y2U3@57723|Acidobacteria,2JI6I@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TLS2_k127_3058489_6	448385.sce1206	1.195e-20	98.0	2A461@1|root,30SR2@2|Bacteria,1PC3D@1224|Proteobacteria,433A7@68525|delta/epsilon subdivisions,2WXTE@28221|Deltaproteobacteria,2YW5Q@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3058489_5	1267535.KB906767_gene4670	6.318e-54	192.0	COG0438@1|root,COG0438@2|Bacteria,3Y6A8@57723|Acidobacteria	57723|Acidobacteria	M	Domain of unknown function (DUF1972)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1972,Glyco_trans_1_4
TLS2_k127_305946_1	477641.MODMU_1475	2.235e-12	74.0	2C254@1|root,2ZWPJ@2|Bacteria,2INBE@201174|Actinobacteria,4EW8T@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_305946_0	1496688.ER33_00090	1.289e-146	497.0	COG0457@1|root,COG0457@2|Bacteria	1496688.ER33_00090|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3065721_3	690850.Desaf_2479	1.724e-18	93.0	COG3861@1|root,COG3861@2|Bacteria,1RJWQ@1224|Proteobacteria	1224|Proteobacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382
TLS2_k127_3065721_2	234267.Acid_0591	1.654e-40	158.0	COG0251@1|root,COG0251@2|Bacteria,3Y5DN@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS2_k127_3065721_0	1267535.KB906767_gene4447	2.133e-171	555.0	COG1432@1|root,COG1432@2|Bacteria,3Y64C@57723|Acidobacteria	57723|Acidobacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
TLS2_k127_3065721_1	234267.Acid_6471	6.522e-60	211.0	COG2185@1|root,COG2185@2|Bacteria,3Y4YE@57723|Acidobacteria	57723|Acidobacteria	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
TLS2_k127_3065721_4	891968.Anamo_2045	1.356e-14	75.0	COG1884@1|root,COG1884@2|Bacteria,3T9QP@508458|Synergistetes	508458|Synergistetes	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS2_k127_3071836_2	1267535.KB906767_gene5335	4.817e-49	180.0	COG3328@1|root,COG3328@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	Transposase_mut
TLS2_k127_3071836_1	1354314.CHV_a0267	2.7e-52	194.0	COG3344@1|root,COG3344@2|Bacteria,4NHMS@976|Bacteroidetes,47X91@768503|Cytophagia	976|Bacteroidetes	L	Group II intron, maturase-specific domain	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,HNH,Intron_maturas2,RVT_1,RVT_N
TLS2_k127_3071836_3	224911.27350214	1.028e-11	69.0	2FDBU@1|root,345DN@2|Bacteria,1NPWB@1224|Proteobacteria,2UT7E@28211|Alphaproteobacteria,3K4EQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
TLS2_k127_3071836_0	398525.KB900702_gene117	4.37e-208	663.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3JV1X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Recombinase zinc beta ribbon domain	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_3071836_4	522306.CAP2UW1_4281	1.072e-05	49.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2VK01@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Resolvase domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_30739_2	234267.Acid_6674	9.754e-71	242.0	COG0535@1|root,COG0535@2|Bacteria,3Y5QY@57723|Acidobacteria	57723|Acidobacteria	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
TLS2_k127_30739_4	1267535.KB906767_gene2621	1.058e-06	59.0	2985T@1|root,2ZVBP@2|Bacteria,3Y971@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_30739_3	485913.Krac_5622	2.972e-41	156.0	COG5207@1|root,COG5207@2|Bacteria	2|Bacteria	O	Pfam Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N,zf-UBP
TLS2_k127_30739_0	234267.Acid_0438	3.465e-127	422.0	COG0664@1|root,COG4191@1|root,COG0664@2|Bacteria,COG4191@2|Bacteria,3Y99Q@57723|Acidobacteria	57723|Acidobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
TLS2_k127_30739_1	1469607.KK073768_gene4661	3.23e-88	295.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1FZX5@1117|Cyanobacteria,1HMXM@1161|Nostocales	1117|Cyanobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
TLS2_k127_307637_1	1396418.BATQ01000127_gene2555	9.262e-119	393.0	COG2072@1|root,COG2072@2|Bacteria,46U3S@74201|Verrucomicrobia	74201|Verrucomicrobia	P	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_307637_0	1267535.KB906767_gene1476	1.291e-135	443.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_307637_2	926569.ANT_03070	2.466e-19	103.0	COG5295@1|root,COG5295@2|Bacteria,2G7I4@200795|Chloroflexi	200795|Chloroflexi	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3077445_2	861299.J421_0487	2.872e-10	68.0	COG2936@1|root,COG2936@2|Bacteria,1ZUE2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
TLS2_k127_3077445_1	401053.AciPR4_1074	9.538e-80	299.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_3077445_0	1340493.JNIF01000004_gene177	7.632e-177	573.0	COG1657@1|root,COG3391@1|root,COG1657@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K14647,ko:K21449	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000,ko03110	1.B.40.2	-	-	-
TLS2_k127_3078759_0	1329516.JPST01000005_gene1458	2.655e-190	602.0	COG2224@1|root,COG2224@2|Bacteria,1TP1U@1239|Firmicutes,4HBBD@91061|Bacilli,27BEB@186824|Thermoactinomycetaceae	91061|Bacilli	C	Isocitrate lyase family	aceA	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
TLS2_k127_3078759_1	234267.Acid_3107	6.496e-164	535.0	COG2225@1|root,COG2225@2|Bacteria,3Y4MK@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the malate synthase family	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
TLS2_k127_309588_4	1267534.KB906754_gene3224	2.461e-15	76.0	COG1725@1|root,COG1725@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
TLS2_k127_309588_5	452637.Oter_1832	6.993e-11	72.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_309588_3	1267535.KB906767_gene630	1.762e-112	366.0	COG1136@1|root,COG1136@2|Bacteria,3Y2X0@57723|Acidobacteria,2JHYU@204432|Acidobacteriia	204432|Acidobacteriia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_309588_2	1267535.KB906767_gene632	9.779e-126	405.0	COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria,2JIKD@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_309588_1	234267.Acid_6482	1.425e-145	472.0	COG0845@1|root,COG0845@2|Bacteria,3Y2FV@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM efflux transporter, RND family, MFP subunit	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
TLS2_k127_309588_0	234267.Acid_5307	1.6e-163	522.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,3Y3EF@57723|Acidobacteria	57723|Acidobacteria	C	2-oxoglutarate dehydrogenase, E1	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,E1_dh,OxoGdeHyase_C,Transket_pyr
TLS2_k127_3096149_2	243090.RB1909	7.086e-10	61.0	COG1017@1|root,COG1017@2|Bacteria,2J3ES@203682|Planctomycetes	203682|Planctomycetes	C	Globin	-	-	-	-	-	-	-	-	-	-	-	-	Globin
TLS2_k127_3096149_0	234267.Acid_3444	7.259e-146	496.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y3NW@57723|Acidobacteria	57723|Acidobacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_3096149_1	1340493.JNIF01000003_gene4208	4.583e-53	194.0	COG1595@1|root,COG1595@2|Bacteria,3Y7UW@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_3103166_3	1267535.KB906767_gene3039	1.787e-16	80.0	COG0764@1|root,COG0764@2|Bacteria,3Y4CG@57723|Acidobacteria,2JJ97@204432|Acidobacteriia	204432|Acidobacteriia	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
TLS2_k127_3103166_1	234267.Acid_6203	1.408e-117	382.0	COG1043@1|root,COG1043@2|Bacteria,3Y33C@57723|Acidobacteria	57723|Acidobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
TLS2_k127_3103166_2	234267.Acid_6204	4.695e-107	363.0	COG3494@1|root,COG3494@2|Bacteria,3Y3KI@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
TLS2_k127_3103166_0	234267.Acid_1734	4.016e-198	636.0	COG0612@1|root,COG0612@2|Bacteria,3Y2UB@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_3103562_4	234267.Acid_5307	3.096e-71	246.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,3Y3EF@57723|Acidobacteria	57723|Acidobacteria	C	2-oxoglutarate dehydrogenase, E1	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,E1_dh,OxoGdeHyase_C,Transket_pyr
TLS2_k127_3103562_2	1121904.ARBP01000040_gene530	4.993e-95	329.0	COG3119@1|root,COG3119@2|Bacteria,4NGX1@976|Bacteroidetes,47K2H@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_3103562_0	639030.JHVA01000001_gene590	9.641e-197	653.0	COG1629@1|root,COG4771@2|Bacteria,3Y2WI@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_3103562_1	1267533.KB906738_gene2071	7.78e-137	442.0	COG0535@1|root,COG0535@2|Bacteria,3Y3TY@57723|Acidobacteria,2JM20@204432|Acidobacteriia	204432|Acidobacteriia	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
TLS2_k127_3103562_3	1123270.ATUR01000007_gene1282	3.791e-78	269.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria,2K4ZJ@204457|Sphingomonadales	204457|Sphingomonadales	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS2_k127_3107497_2	658088.HMPREF0987_01600	0.000686	44.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,248AY@186801|Clostridia,27IRN@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Aminotransferase class I and II	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_3107497_0	104623.Ser39006_02397	5.756e-41	162.0	COG1309@1|root,COG1309@2|Bacteria,1R13H@1224|Proteobacteria,1SD8W@1236|Gammaproteobacteria,405P7@613|Serratia	1236|Gammaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_3107497_1	1380390.JIAT01000011_gene2442	0.000595	50.0	COG2867@1|root,COG2867@2|Bacteria	2|Bacteria	I	negative regulation of translational initiation	QU41_28450	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_3109032_0	935548.KI912159_gene3293	6.577e-59	211.0	COG0451@1|root,COG0451@2|Bacteria,1MXYR@1224|Proteobacteria,2TT4T@28211|Alphaproteobacteria,43JJE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10,NmrA,RmlD_sub_bind
TLS2_k127_3109032_1	1120936.KB907221_gene2112	5.164e-41	171.0	COG2159@1|root,COG2159@2|Bacteria,2GN9D@201174|Actinobacteria	201174|Actinobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
TLS2_k127_3123279_2	234267.Acid_0127	2.422e-58	210.0	COG1102@1|root,COG1102@2|Bacteria	2|Bacteria	F	Psort location Cytoplasmic, score	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Cytidylate_kin2,GAF_2,Pribosyltran
TLS2_k127_3123279_1	234267.Acid_0682	1.507e-68	253.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	glkA	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_3123279_0	1267535.KB906767_gene2247	3.123e-233	736.0	COG1053@1|root,COG1053@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_3123279_3	1519464.HY22_02935	4.143e-43	162.0	COG0454@1|root,COG0456@2|Bacteria,1FF9G@1090|Chlorobi	1090|Chlorobi	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_3124524_2	1396418.BATQ01000185_gene2114	2.507e-09	70.0	COG1404@1|root,COG3386@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3386@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,Exo_endo_phos,Glyco_hydro_25,NHL,Peptidase_S8,SLH,TIG
TLS2_k127_3124524_3	1215114.BBIU01000014_gene2104	1.345e-05	58.0	COG2931@1|root,COG2931@2|Bacteria,1R1K6@1224|Proteobacteria	1224|Proteobacteria	Q	Domain of unknown function (DUF4214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214
TLS2_k127_3124524_1	234267.Acid_3815	1.56e-242	755.0	COG0493@1|root,COG0493@2|Bacteria,3Y2JM@57723|Acidobacteria	57723|Acidobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
TLS2_k127_3124524_0	102232.GLO73106DRAFT_00000120	0.0	1116.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1G0XM@1117|Cyanobacteria	1117|Cyanobacteria	E	Glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TLS2_k127_3132829_1	1229205.BUPH_03230	8.224e-07	61.0	COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,2VR7H@28216|Betaproteobacteria,1K1TE@119060|Burkholderiaceae	28216|Betaproteobacteria	M	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
TLS2_k127_3132829_2	886293.Sinac_3442	0.0001275	51.0	COG0526@1|root,COG1470@1|root,COG1595@1|root,COG0526@2|Bacteria,COG1470@2|Bacteria,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	AhpC-TSA,DUF4384,NPCBM_assoc,PEGA,Sigma70_r2,Sigma70_r4_2,Thioredoxin_8
TLS2_k127_3132829_0	237368.SCABRO_00954	9.363e-148	483.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
TLS2_k127_3134338_3	1267535.KB906767_gene355	6.557e-50	181.0	COG3119@1|root,COG3119@2|Bacteria,3Y6Y5@57723|Acidobacteria	57723|Acidobacteria	P	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_3134338_1	1267535.KB906767_gene356	3.765e-235	753.0	COG2010@1|root,COG2010@2|Bacteria,3Y6P3@57723|Acidobacteria	57723|Acidobacteria	C	Protein of unknown function (DUF1553)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_3134338_2	234267.Acid_0930	4.778e-212	668.0	COG2960@1|root,COG2960@2|Bacteria	2|Bacteria	M	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
TLS2_k127_3134338_0	1340493.JNIF01000004_gene927	0.0	1103.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt3,PSD2,PSD3,PSD4,PSD5
TLS2_k127_313654_5	1089551.KE386572_gene773	1.242e-41	171.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TVKK@28211|Alphaproteobacteria,4BS83@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_313654_1	861299.J421_1196	4.943e-102	346.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	exuT	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
TLS2_k127_313654_2	1123239.KB898623_gene1625	2.159e-84	295.0	COG4948@1|root,COG4948@2|Bacteria,1UYDG@1239|Firmicutes,4HF62@91061|Bacilli	91061|Bacilli	M	Mandelate racemase / muconate lactonizing enzyme, N-terminal domain	-	-	4.2.1.158	ko:K20022	-	-	-	-	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_313654_0	1185876.BN8_02551	1.122e-180	587.0	COG2730@1|root,COG2730@2|Bacteria,4NKKV@976|Bacteroidetes,47TPT@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolase family 115	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_115
TLS2_k127_313654_4	1267535.KB906767_gene3253	2.068e-62	228.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_313654_3	641524.ADICYQ_2835	3.005e-72	252.0	COG3836@1|root,COG3836@2|Bacteria,4NH2V@976|Bacteroidetes,47JVN@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.20,4.1.2.52,4.1.2.53	ko:K01630,ko:K02510,ko:K12660	ko00051,ko00053,ko00350,ko01120,map00051,map00053,map00350,map01120	-	R01645,R01647,R02261,R02754,R03277	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_3140962_0	234267.Acid_2813	1.132e-186	601.0	COG0577@1|root,COG0577@2|Bacteria,3Y6QF@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_3140962_1	1267535.KB906767_gene3219	1.054e-55	200.0	COG1695@1|root,COG1695@2|Bacteria,3Y7WH@57723|Acidobacteria,2JP2D@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_3140962_2	1278073.MYSTI_01766	4.21e-48	180.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_3141306_5	1280954.HPO_10135	1.055e-24	113.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2U99Y@28211|Alphaproteobacteria,43XXW@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
TLS2_k127_3141306_4	204669.Acid345_0517	3.655e-25	111.0	2E4M2@1|root,32ZG2@2|Bacteria,3Y5MC@57723|Acidobacteria,2JNHX@204432|Acidobacteriia	204432|Acidobacteriia	S	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase
TLS2_k127_3141306_1	997346.HMPREF9374_2990	1.973e-67	240.0	COG1984@1|root,COG1984@2|Bacteria,1TR6U@1239|Firmicutes,4HACC@91061|Bacilli,27AVH@186824|Thermoactinomycetaceae	91061|Bacilli	E	Allophanate hydrolase subunit 2	kipA	-	-	ko:K06350	-	-	-	-	ko00000	-	-	-	CT_A_B
TLS2_k127_3141306_3	243233.MCA0478	4.617e-50	186.0	COG2049@1|root,COG2049@2|Bacteria,1MWRB@1224|Proteobacteria,1RQIQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Allophanate hydrolase, subunit 1	ybgJ	-	-	-	-	-	-	-	-	-	-	-	CT_C_D
TLS2_k127_3141306_2	2074.JNYD01000001_gene6136	2.627e-66	237.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria,4DXH8@85010|Pseudonocardiales	201174|Actinobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
TLS2_k127_3141306_0	266117.Rxyl_0146	1.054e-80	275.0	COG0243@1|root,COG0243@2|Bacteria,2GJWZ@201174|Actinobacteria,4CQ1R@84995|Rubrobacteria	84995|Rubrobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
TLS2_k127_3156142_2	234267.Acid_4341	3.577e-30	124.0	COG1331@1|root,COG1331@2|Bacteria	2|Bacteria	O	Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888,ko:K20948	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Glyco_hydro_88
TLS2_k127_3156142_0	1340493.JNIF01000003_gene1961	2.421e-251	803.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_2
TLS2_k127_3156142_1	518766.Rmar_2604	1.052e-247	775.0	COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,1FJZQ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
TLS2_k127_3157836_2	234267.Acid_2627	2.977e-61	221.0	COG2152@1|root,COG2152@2|Bacteria,3Y5H3@57723|Acidobacteria	57723|Acidobacteria	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_3157836_0	234267.Acid_0723	9.46e-143	459.0	COG0002@1|root,COG0002@2|Bacteria,3Y450@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_3157836_1	234267.Acid_0724	7.332e-75	256.0	COG0548@1|root,COG0548@2|Bacteria,3Y2IF@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
TLS2_k127_3158345_2	329726.AM1_5063	7.461e-13	79.0	COG2931@1|root,COG2931@2|Bacteria,1G5FC@1117|Cyanobacteria	1117|Cyanobacteria	Q	domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,HemolysinCabind,Spond_N
TLS2_k127_3158345_0	1157708.KB907458_gene1917	7.267e-126	416.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHT0@28216|Betaproteobacteria,4AD3F@80864|Comamonadaceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3158345_1	261292.Nit79A3_1297	4.475e-41	154.0	COG3221@1|root,COG3221@2|Bacteria,1N92V@1224|Proteobacteria,2WBUH@28216|Betaproteobacteria,373TX@32003|Nitrosomonadales	28216|Betaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Phosphonate-bd
TLS2_k127_3159367_2	234267.Acid_5054	2.295e-45	173.0	COG2318@1|root,COG2318@2|Bacteria,3Y579@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
TLS2_k127_3159367_5	1121920.AUAU01000004_gene593	1.166e-22	102.0	COG3070@1|root,COG3070@2|Bacteria	2|Bacteria	K	positive regulation of type IV pilus biogenesis	-	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
TLS2_k127_3159367_3	1242864.D187_007745	2.585e-36	153.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,42PVD@68525|delta/epsilon subdivisions,2WN8S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_3159367_4	926550.CLDAP_10380	7.461e-36	153.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.349	ko:K12994	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_3159367_1	234267.Acid_6230	4.864e-112	375.0	COG0438@1|root,COG0438@2|Bacteria,3Y64B@57723|Acidobacteria	2|Bacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
TLS2_k127_3159367_0	1340493.JNIF01000003_gene2968	3.54e-143	464.0	COG0438@1|root,COG0438@2|Bacteria,3Y58K@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_3165578_3	234267.Acid_7619	2.051e-125	406.0	COG1484@1|root,COG1484@2|Bacteria,3Y7G6@57723|Acidobacteria	2|Bacteria	L	PFAM IstB domain protein ATP-binding protein	istB3	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21,IstB_IS21_ATP
TLS2_k127_3165578_0	234267.Acid_7618	4.335e-183	580.0	COG4584@1|root,COG4584@2|Bacteria,3Y630@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_3165578_2	1082933.MEA186_27670	2.515e-137	448.0	COG4974@1|root,COG4974@2|Bacteria,1R72R@1224|Proteobacteria,2U27G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_3165578_4	1082933.MEA186_27675	1.168e-109	364.0	COG0582@1|root,COG0582@2|Bacteria,1NX90@1224|Proteobacteria,2U3EM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_3165578_1	1082933.MEA186_27680	1.444e-145	470.0	COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2U0B6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_3166491_0	1267535.KB906767_gene1302	8.124e-129	415.0	COG0037@1|root,COG0037@2|Bacteria,3Y548@57723|Acidobacteria	57723|Acidobacteria	D	PP-loop family	-	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
TLS2_k127_3166491_3	1340493.JNIF01000003_gene2735	2.006e-86	301.0	COG2304@1|root,COG2304@2|Bacteria,3Y8A4@57723|Acidobacteria	57723|Acidobacteria	S	VWA domain containing CoxE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
TLS2_k127_3166491_2	234267.Acid_5411	7.884e-90	305.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_3166491_1	886293.Sinac_3465	3.557e-114	384.0	COG3356@1|root,COG3356@2|Bacteria,2IXDY@203682|Planctomycetes	203682|Planctomycetes	G	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
TLS2_k127_3166491_4	234267.Acid_6247	6.778e-68	248.0	COG0673@1|root,COG0673@2|Bacteria,3Y39X@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_3167491_0	1267533.KB906740_gene290	8.923e-111	379.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria	57723|Acidobacteria	KU	WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_3167491_1	234267.Acid_7677	4.117e-40	155.0	COG1595@1|root,COG1595@2|Bacteria,3Y7UW@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_3169768_0	1340493.JNIF01000004_gene211	6.995e-191	612.0	COG0795@1|root,COG0795@2|Bacteria,3Y2F9@57723|Acidobacteria	57723|Acidobacteria	S	Permease, YjgP YjgQ	-	-	-	-	-	-	-	-	-	-	-	-	YjgP_YjgQ
TLS2_k127_3169768_1	1267535.KB906767_gene2350	5.646e-131	420.0	COG1217@1|root,COG1217@2|Bacteria,3Y33Q@57723|Acidobacteria,2JIIC@204432|Acidobacteriia	204432|Acidobacteriia	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_3170715_1	926566.Terro_2314	1.27e-37	150.0	2EZNS@1|root,33STS@2|Bacteria,3Y75C@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3170715_0	1267535.KB906767_gene2758	8.194e-192	619.0	COG1449@1|root,COG1449@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_20,Glyco_hydro_57,Polysacc_deac_1,SLH
TLS2_k127_3171807_2	83332.Rv3122	0.0001568	48.0	2C62F@1|root,335K1@2|Bacteria,2GS5K@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3171807_0	189753.AXAS01000037_gene7858	6.251e-174	559.0	COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,2UEEB@28211|Alphaproteobacteria,3K063@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
TLS2_k127_3171807_1	1123242.JH636434_gene4782	2.782e-46	168.0	COG3464@1|root,COG3464@2|Bacteria,2J3VD@203682|Planctomycetes	203682|Planctomycetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3
TLS2_k127_3173781_0	234267.Acid_3484	0.0	1126.0	COG0457@1|root,COG0457@2|Bacteria,3Y2Q7@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
TLS2_k127_3173781_1	234267.Acid_3485	1.109e-252	789.0	COG0457@1|root,COG0457@2|Bacteria,3Y2M9@57723|Acidobacteria	57723|Acidobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS2_k127_3173781_9	1335757.SPICUR_06090	4.146e-49	178.0	COG1553@1|root,COG1553@2|Bacteria,1NB8E@1224|Proteobacteria,1SR7X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3173781_4	1267535.KB906767_gene2406	2.838e-144	464.0	COG1082@1|root,COG1082@2|Bacteria,3Y2PT@57723|Acidobacteria,2JI9Z@204432|Acidobacteriia	204432|Acidobacteriia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_3173781_8	1454004.AW11_00497	1.602e-71	248.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VKBQ@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
TLS2_k127_3173781_10	1340493.JNIF01000004_gene261	1.68e-43	164.0	COG2318@1|root,COG2318@2|Bacteria,3Y8BV@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1572)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1572
TLS2_k127_3173781_2	1267535.KB906767_gene801	3.781e-184	584.0	COG4992@1|root,COG4992@2|Bacteria,3Y36P@57723|Acidobacteria,2JISH@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class-III	-	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_3173781_11	622637.KE124774_gene431	4.274e-37	151.0	COG2059@1|root,COG2059@2|Bacteria,1RCDP@1224|Proteobacteria,2U6CH@28211|Alphaproteobacteria,36ZMY@31993|Methylocystaceae	28211|Alphaproteobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
TLS2_k127_3173781_12	395963.Bind_0648	9.408e-21	100.0	COG2059@1|root,COG2059@2|Bacteria,1RGZC@1224|Proteobacteria,2UBKX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
TLS2_k127_3173781_3	234267.Acid_2187	7.07e-165	528.0	COG0019@1|root,COG0019@2|Bacteria,3Y2W4@57723|Acidobacteria	57723|Acidobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS2_k127_3173781_6	1210884.HG799465_gene12146	7.015e-75	266.0	COG1520@1|root,COG1520@2|Bacteria,2J2YU@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_3173781_5	1382359.JIAL01000001_gene2838	8.96e-135	434.0	KOG1573@1|root,2Z822@2|Bacteria,3Y3AN@57723|Acidobacteria,2JKNN@204432|Acidobacteriia	204432|Acidobacteriia	S	Myo-inositol oxygenase	-	-	1.13.99.1	ko:K00469	ko00053,ko00562,map00053,map00562	-	R01184	RC00465	ko00000,ko00001,ko01000	-	-	-	MIOX
TLS2_k127_3173781_7	1123278.KB893615_gene5179	1.052e-71	273.0	COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,4NNEF@976|Bacteroidetes,47PBP@768503|Cytophagia	976|Bacteroidetes	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
TLS2_k127_3174565_2	1033732.CAHI01000009_gene1742	1.596e-23	102.0	COG0560@1|root,COG3830@1|root,COG0560@2|Bacteria,COG3830@2|Bacteria,4NHAG@976|Bacteroidetes,2FNI5@200643|Bacteroidia	976|Bacteroidetes	ET	phosphoserine phosphatase	serB	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	ACT_6,HAD
TLS2_k127_3174565_1	234267.Acid_1152	1.161e-32	133.0	COG0346@1|root,COG0346@2|Bacteria,3Y8F5@57723|Acidobacteria	57723|Acidobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_3174565_3	1340493.JNIF01000003_gene2984	5.291e-17	85.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
TLS2_k127_3174565_0	234267.Acid_3789	5.266e-44	165.0	COG2971@1|root,COG2971@2|Bacteria,3Y2J3@57723|Acidobacteria	57723|Acidobacteria	G	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
TLS2_k127_317538_1	234267.Acid_0686	5.601e-13	75.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_0686|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_317538_0	1267535.KB906767_gene4512	1.012e-210	677.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_3177987_2	234267.Acid_2002	1.765e-46	188.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_2002|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3177987_0	1340493.JNIF01000003_gene3546	1.335e-101	343.0	COG0628@1|root,COG0628@2|Bacteria,3Y4N5@57723|Acidobacteria	57723|Acidobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_3177987_1	1211813.CAPH01000005_gene1694	1.686e-93	312.0	COG3546@1|root,COG3546@2|Bacteria,4NHRJ@976|Bacteroidetes,2FR97@200643|Bacteroidia	976|Bacteroidetes	P	Manganese containing catalase	-	-	-	ko:K07217	-	-	-	-	ko00000	-	-	-	Mn_catalase
TLS2_k127_3178672_1	1340493.JNIF01000003_gene3565	1.887e-105	350.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_3178672_3	240015.ACP_0992	1.632e-30	127.0	COG0457@1|root,COG0457@2|Bacteria	240015.ACP_0992|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3178672_4	1123278.KB893422_gene1616	1.281e-19	93.0	COG4319@1|root,COG4319@2|Bacteria,4NSA0@976|Bacteroidetes,47RMW@768503|Cytophagia	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_3178672_0	330214.NIDE1985	0.0	1074.0	COG0542@1|root,COG0542@2|Bacteria,3J0W0@40117|Nitrospirae	40117|Nitrospirae	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K11907	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	AAA,AAA_2,ClpB_D2-small
TLS2_k127_3179029_0	94624.Bpet1409	9.945e-230	719.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2VK01@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Resolvase domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_3179029_1	94624.Bpet1408	5.674e-50	182.0	COG3415@1|root,COG3415@2|Bacteria,1RKUV@1224|Proteobacteria,2WFVI@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29
TLS2_k127_3179029_2	1267535.KB906767_gene700	8.783e-21	95.0	2EHAG@1|root,3394C@2|Bacteria	2|Bacteria	S	Family of unknown function (DUF5372)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5372
TLS2_k127_3179029_3	240015.ACP_0450	1.711e-10	62.0	COG2801@1|root,COG2801@2|Bacteria,3Y6NP@57723|Acidobacteria,2JNG9@204432|Acidobacteriia	204432|Acidobacteriia	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3179668_0	234267.Acid_4186	5.34e-131	435.0	COG3485@1|root,COG3485@2|Bacteria,3Y3AH@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_3179808_0	1340493.JNIF01000003_gene2329	2.302e-61	216.0	COG4993@1|root,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
TLS2_k127_3179808_1	526224.Bmur_0447	8.301e-34	146.0	COG0716@1|root,COG1262@1|root,COG0716@2|Bacteria,COG1262@2|Bacteria,2J5Y8@203691|Spirochaetes	203691|Spirochaetes	C	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Flavodoxin_4
TLS2_k127_3179909_4	926556.Echvi_2925	1.661e-27	121.0	28K60@1|root,2Z9UH@2|Bacteria,4NHE6@976|Bacteroidetes,47UNS@768503|Cytophagia	976|Bacteroidetes	S	Methane oxygenase PmoA	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
TLS2_k127_3179909_0	1211114.ALIP01000127_gene572	5.036e-180	573.0	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,1RRMM@1236|Gammaproteobacteria,1X2YX@135614|Xanthomonadales	135614|Xanthomonadales	E	phospho-2-dehydro-3-deoxyheptonate aldolase	dhs1	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
TLS2_k127_3179909_1	1173026.Glo7428_1703	1.498e-120	399.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1G0MX@1117|Cyanobacteria	1117|Cyanobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	-	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
TLS2_k127_3179909_2	1267535.KB906767_gene4765	2.487e-95	320.0	COG1119@1|root,COG1119@2|Bacteria,3Y2Z4@57723|Acidobacteria,2JHX4@204432|Acidobacteriia	204432|Acidobacteriia	P	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
TLS2_k127_3179909_3	861299.J421_0074	1.163e-49	181.0	COG0708@1|root,COG0708@2|Bacteria	2|Bacteria	L	double-stranded DNA 3'-5' exodeoxyribonuclease activity	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
TLS2_k127_3180502_1	234267.Acid_7874	2.115e-27	112.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_3180502_0	234267.Acid_7873	2.474e-191	604.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	crdA	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_3181603_2	234267.Acid_2117	3.922e-45	169.0	COG2271@1|root,COG2271@2|Bacteria,3Y6CQ@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
TLS2_k127_3181603_1	234267.Acid_2116	8.244e-68	252.0	COG4783@1|root,COG4783@2|Bacteria,3Y7PN@57723|Acidobacteria	57723|Acidobacteria	S	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3181603_3	1340493.JNIF01000004_gene826	6.812e-44	165.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_3181603_0	1340493.JNIF01000003_gene3795	9.819e-101	336.0	COG1028@1|root,COG1028@2|Bacteria,3Y67C@57723|Acidobacteria	57723|Acidobacteria	IQ	KR domain	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
TLS2_k127_3181603_4	1340493.JNIF01000003_gene3794	1.249e-10	63.0	COG4244@1|root,COG4244@2|Bacteria,3Y7HJ@57723|Acidobacteria	57723|Acidobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3182827_5	1123368.AUIS01000004_gene185	4.657e-10	60.0	COG0384@1|root,COG0384@2|Bacteria,1R9X4@1224|Proteobacteria,1RZ0R@1236|Gammaproteobacteria,2NCTG@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
TLS2_k127_3182827_0	1121904.ARBP01000008_gene3234	8.395e-200	658.0	COG5492@1|root,COG5492@2|Bacteria,4NEAB@976|Bacteroidetes,47TBW@768503|Cytophagia	976|Bacteroidetes	N	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF5060
TLS2_k127_3182827_2	1121904.ARBP01000004_gene782	1.644e-92	338.0	COG1680@1|root,COG1680@2|Bacteria,4NEVS@976|Bacteroidetes,47JKN@768503|Cytophagia	976|Bacteroidetes	V	Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_3182827_3	234267.Acid_0410	4.407e-49	187.0	COG0741@1|root,COG0741@2|Bacteria,3Y4SM@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Lytic transglycosylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TLS2_k127_3182827_1	530564.Psta_2567	7.509e-135	437.0	COG3828@1|root,COG3828@2|Bacteria,2IY8Q@203682|Planctomycetes	203682|Planctomycetes	S	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
TLS2_k127_3182827_4	234267.Acid_0546	6.64e-18	86.0	COG0498@1|root,COG0498@2|Bacteria,3Y2GX@57723|Acidobacteria	57723|Acidobacteria	E	TIGRFAM Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_3184941_5	1123256.KB907945_gene368	1.479e-05	50.0	2BGHV@1|root,32AG3@2|Bacteria,1NCU1@1224|Proteobacteria,1T0UQ@1236|Gammaproteobacteria,1X8FV@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF3237)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3237
TLS2_k127_3184941_4	32049.SYNPCC7002_A0631	7.273e-16	83.0	COG4634@1|root,COG4634@2|Bacteria,1GJH9@1117|Cyanobacteria,1H3KT@1129|Synechococcus	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3184941_2	234267.Acid_5681	7.878e-37	139.0	COG2442@1|root,COG2442@2|Bacteria	2|Bacteria	K	InterPro IPR007367	-	-	-	-	-	-	-	-	-	-	-	-	DUF433,MerR_1
TLS2_k127_3184941_3	272568.GDI3860	2.627e-21	95.0	COG0582@1|root,COG0582@2|Bacteria,1MXNK@1224|Proteobacteria,2TUAT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_3184941_0	666685.R2APBS1_0457	1.355e-86	295.0	COG3568@1|root,COG3568@2|Bacteria,1PPNP@1224|Proteobacteria,1S9D7@1236|Gammaproteobacteria,1X46I@135614|Xanthomonadales	135614|Xanthomonadales	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_3184941_1	1267535.KB906767_gene4313	3.14e-54	192.0	COG0439@1|root,COG0439@2|Bacteria,3Y2QZ@57723|Acidobacteria,2JIFS@204432|Acidobacteriia	204432|Acidobacteriia	I	acetyl-CoA carboxylase, biotin carboxylase	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TLS2_k127_3185243_2	1340493.JNIF01000003_gene4658	6.442e-58	205.0	COG0633@1|root,COG0633@2|Bacteria,3Y4T7@57723|Acidobacteria	57723|Acidobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
TLS2_k127_3185243_5	234267.Acid_5891	3.671e-21	94.0	COG3205@1|root,COG3205@2|Bacteria	2|Bacteria	P	membrane	-	-	2.7.1.25,2.7.7.4	ko:K00860,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF2061
TLS2_k127_3185243_0	1267535.KB906767_gene1458	1.605e-288	899.0	COG0018@1|root,COG0018@2|Bacteria,3Y35R@57723|Acidobacteria,2JIAM@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
TLS2_k127_3185243_4	234267.Acid_4941	1.596e-45	168.0	COG1225@1|root,COG1225@2|Bacteria,3Y7Y4@57723|Acidobacteria	57723|Acidobacteria	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS2_k127_3185243_1	1267535.KB906767_gene3025	2.764e-236	746.0	COG0364@1|root,COG0364@2|Bacteria,3Y2JZ@57723|Acidobacteria,2JHKE@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TLS2_k127_3185243_3	234267.Acid_5280	2.077e-55	202.0	COG3429@1|root,COG3429@2|Bacteria,3Y7S9@57723|Acidobacteria	57723|Acidobacteria	G	Glucose-6-phosphate dehydrogenase subunit	-	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
TLS2_k127_3185480_5	234267.Acid_0449	9.221e-43	162.0	COG1801@1|root,COG1801@2|Bacteria,3Y2F1@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS2_k127_3185480_1	1242864.D187_004781	1.301e-168	542.0	COG2730@1|root,COG2730@2|Bacteria,1R544@1224|Proteobacteria	1224|Proteobacteria	G	Protein of unknown function (DUF4038)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038
TLS2_k127_3185480_2	204669.Acid345_0127	6.543e-143	462.0	COG0075@1|root,COG0075@2|Bacteria,3Y2Q8@57723|Acidobacteria,2JKUD@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_3185480_0	234267.Acid_3107	7.961e-229	719.0	COG2225@1|root,COG2225@2|Bacteria,3Y4MK@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the malate synthase family	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
TLS2_k127_3185480_4	886293.Sinac_3318	3.449e-45	179.0	COG2271@1|root,COG2807@1|root,COG2271@2|Bacteria,COG2807@2|Bacteria,2IZV2@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
TLS2_k127_3185480_3	234267.Acid_2421	9.286e-128	418.0	COG1319@1|root,COG1319@2|Bacteria,3Y3NU@57723|Acidobacteria	57723|Acidobacteria	C	PFAM molybdopterin dehydrogenase, FAD-binding	-	-	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_3185480_6	234267.Acid_2420	1.734e-11	65.0	COG1529@1|root,COG1529@2|Bacteria,3Y2ME@57723|Acidobacteria	57723|Acidobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_3187677_2	1123508.JH636442_gene3937	7.564e-17	86.0	COG2010@1|root,COG2010@2|Bacteria,2J2AZ@203682|Planctomycetes	203682|Planctomycetes	C	Protein of unknown function (DUF1553)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_3187677_1	1123508.JH636439_gene1122	1.24e-153	499.0	COG4102@1|root,COG4102@2|Bacteria,2IY0N@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_3187677_0	1340493.JNIF01000003_gene1813	3.876e-192	611.0	COG3119@1|root,COG3119@2|Bacteria,3Y3PF@57723|Acidobacteria	57723|Acidobacteria	P	PFAM Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_3189195_5	639030.JHVA01000001_gene1218	3.76e-21	96.0	COG1725@1|root,COG1725@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
TLS2_k127_3189195_1	1267534.KB906754_gene3223	3.664e-102	342.0	COG1131@1|root,COG1131@2|Bacteria,3Y6H3@57723|Acidobacteria,2JM7H@204432|Acidobacteriia	204432|Acidobacteriia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_3189195_6	1198114.AciX9_0787	7.011e-15	88.0	2F1DC@1|root,33UE4@2|Bacteria,3Y7M2@57723|Acidobacteria,2JMR0@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3189195_2	234267.Acid_4819	3.666e-100	346.0	COG0810@1|root,COG4219@1|root,COG0810@2|Bacteria,COG4219@2|Bacteria,3Y8M9@57723|Acidobacteria	57723|Acidobacteria	KMT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Peptidase_M56,TonB_C
TLS2_k127_3189195_4	886293.Sinac_6279	9.213e-41	154.0	COG3682@1|root,COG3682@2|Bacteria,2J0QT@203682|Planctomycetes	203682|Planctomycetes	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
TLS2_k127_3189195_3	234267.Acid_3280	5.734e-84	291.0	COG1162@1|root,COG1162@2|Bacteria,3Y4PC@57723|Acidobacteria	57723|Acidobacteria	S	RsgA GTPase	-	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
TLS2_k127_3189195_0	1340493.JNIF01000003_gene1786	5.073e-137	441.0	COG0162@1|root,COG0162@2|Bacteria,3Y2NC@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TLS2_k127_3189195_7	318586.Pden_3444	3.737e-05	50.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2TS3W@28211|Alphaproteobacteria,2PVCT@265|Paracoccus	28211|Alphaproteobacteria	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K05685	ko02010,map02010	M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
TLS2_k127_3190038_0	1267535.KB906767_gene2285	5.927e-124	400.0	COG0463@1|root,COG0463@2|Bacteria,3Y34G@57723|Acidobacteria,2JIGQ@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_3190038_3	234267.Acid_5171	1.133e-69	246.0	COG0438@1|root,COG0438@2|Bacteria,3Y7XP@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_3190038_2	1340493.JNIF01000003_gene4514	3.639e-85	289.0	COG1989@1|root,COG1989@2|Bacteria,3Y4VX@57723|Acidobacteria	57723|Acidobacteria	NOU	Bacterial Peptidase A24 N-terminal domain	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
TLS2_k127_3190038_1	1340493.JNIF01000003_gene3679	4.376e-87	291.0	COG1077@1|root,COG1077@2|Bacteria,3Y3VC@57723|Acidobacteria	57723|Acidobacteria	D	TIGRFAM Cell shape determining protein MreB Mrl	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TLS2_k127_3192069_0	1267533.KB906740_gene287	5.638e-137	458.0	COG0457@1|root,COG0823@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	DUF4214,SBBP,TPR_19
TLS2_k127_3192069_3	1267533.KB906734_gene4302	6.029e-27	128.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria	57723|Acidobacteria	KU	WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_3192069_2	1123073.KB899242_gene1520	6.384e-29	124.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	4.4.1.3,5.3.3.19	ko:K16953,ko:K19547	ko00920,ko01130,map00920,map01130	M00787	R02574	RC00747,RC00748	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Arg_Hydrox,Cupin_1,Cupin_2
TLS2_k127_3192069_1	485917.Phep_2066	2.672e-34	143.0	COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1IPCG@117747|Sphingobacteriia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
TLS2_k127_3192069_5	118168.MC7420_8054	6.589e-16	88.0	COG0457@1|root,COG0457@2|Bacteria,1G0N0@1117|Cyanobacteria,1HEV3@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_7
TLS2_k127_3195562_2	211165.AJLN01000084_gene1827	9.657e-12	66.0	COG5428@1|root,COG5428@2|Bacteria,1GKRU@1117|Cyanobacteria,1JMMJ@1189|Stigonemataceae	1117|Cyanobacteria	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
TLS2_k127_3195562_0	420324.KI912027_gene312	1.601e-265	870.0	COG5635@1|root,COG5635@2|Bacteria,1MUR7@1224|Proteobacteria,2U15M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3195562_3	1267535.KB906767_gene2913	3.284e-05	48.0	COG4974@1|root,COG4974@2|Bacteria,3Y73V@57723|Acidobacteria	57723|Acidobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_3195562_1	671143.DAMO_0354	6.743e-13	69.0	2DPZI@1|root,3343T@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3212165_0	243090.RB7503	3.397e-114	388.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,2IXKI@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like,VWA
TLS2_k127_3214153_5	234267.Acid_7859	1.109e-79	275.0	COG1565@1|root,COG1565@2|Bacteria,3Y583@57723|Acidobacteria	57723|Acidobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
TLS2_k127_3214153_1	1267535.KB906767_gene2963	3.432e-185	587.0	COG1160@1|root,COG1160@2|Bacteria,3Y3AC@57723|Acidobacteria,2JIAS@204432|Acidobacteriia	204432|Acidobacteriia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
TLS2_k127_3214153_4	234267.Acid_2628	1.29e-159	513.0	COG4948@1|root,COG4948@2|Bacteria,3Y46A@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Mandelate racemase muconate lactonizing enzyme, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C
TLS2_k127_3214153_8	1267535.KB906767_gene4254	3.667e-45	168.0	COG5654@1|root,COG5654@2|Bacteria,3Y5S0@57723|Acidobacteria,2JJWB@204432|Acidobacteriia	204432|Acidobacteriia	S	RES	-	-	-	-	-	-	-	-	-	-	-	-	RES
TLS2_k127_3214153_9	661478.OP10G_3779	4.673e-21	102.0	COG5642@1|root,COG5642@2|Bacteria	2|Bacteria	T	Protein of unknown function (DUF2384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
TLS2_k127_3214153_3	1340493.JNIF01000003_gene2324	8.081e-165	535.0	COG1538@1|root,COG1538@2|Bacteria,3Y7Q2@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS2_k127_3214153_0	1340493.JNIF01000003_gene2325	2.761e-207	651.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	macB_1	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_3214153_2	1340493.JNIF01000003_gene2326	8.2e-185	598.0	COG1566@1|root,COG1566@2|Bacteria	2|Bacteria	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K02005,ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
TLS2_k127_3214153_6	1340493.JNIF01000003_gene2327	7.599e-56	198.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23,OEP
TLS2_k127_3218301_1	1279009.ADICEAN_02287	5.22e-53	196.0	COG2021@1|root,COG2021@2|Bacteria	2|Bacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_3218301_2	1382358.JHVN01000002_gene2257	1.199e-22	105.0	COG2340@1|root,COG2340@2|Bacteria,1UYZ4@1239|Firmicutes,4HBTC@91061|Bacilli,21VI8@150247|Anoxybacillus	91061|Bacilli	S	CAP-associated N-terminal	ylbC	-	-	-	-	-	-	-	-	-	-	-	CAP,CAP_assoc_N
TLS2_k127_3218301_0	1340493.JNIF01000003_gene4600	1.411e-191	613.0	COG1629@1|root,COG4771@2|Bacteria,3Y66U@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_3223936_1	760192.Halhy_5052	2.143e-113	370.0	COG0428@1|root,COG0428@2|Bacteria,4NGQ8@976|Bacteroidetes,1INMZ@117747|Sphingobacteriia	976|Bacteroidetes	P	ZIP Zinc transporter	gufA	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
TLS2_k127_3223936_3	448385.sce1151	3.975e-17	89.0	COG0727@1|root,COG0727@2|Bacteria,1N3UP@1224|Proteobacteria,42U10@68525|delta/epsilon subdivisions,2WQ8S@28221|Deltaproteobacteria,2Z2PB@29|Myxococcales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
TLS2_k127_3223936_2	1123368.AUIS01000001_gene1885	1.496e-107	371.0	COG0510@1|root,COG0510@2|Bacteria,1NUSY@1224|Proteobacteria	1224|Proteobacteria	M	thiamine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3223936_0	234267.Acid_3021	2.457e-149	475.0	COG0451@1|root,COG0451@2|Bacteria,3Y3Q6@57723|Acidobacteria	57723|Acidobacteria	GM	Glycosyl hydrolase catalytic core	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_cc
TLS2_k127_3228437_4	234267.Acid_1483	2.854e-45	168.0	COG3962@1|root,COG3962@2|Bacteria	2|Bacteria	E	Belongs to the TPP enzyme family	iolD	GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009987,GO:0016042,GO:0019637,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0046434,GO:0071704,GO:1901575	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	iYO844.BSU39730	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_3228437_0	485913.Krac_4321	2.429e-208	657.0	COG1012@1|root,COG1012@2|Bacteria,2G8B9@200795|Chloroflexi	200795|Chloroflexi	C	Aldehyde dehydrogenase family	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_3228437_3	234267.Acid_1484	3.884e-143	466.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	iolE	-	1.1.1.18,1.1.1.369,4.2.1.44	ko:K00010,ko:K03335	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R02782,R05659,R09951	RC00182,RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_3228437_2	234267.Acid_1485	3.496e-158	505.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	iolG	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_3228437_1	1382359.JIAL01000001_gene2839	8.4e-159	512.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
TLS2_k127_3228437_5	1042376.AFPK01000029_gene1491	2.048e-19	88.0	COG4102@1|root,COG4102@2|Bacteria,4NE73@976|Bacteroidetes,1HZRB@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_3240013_6	1306990.BARG01000014_gene1350	2.458e-38	159.0	28HPE@1|root,2Z7XE@2|Bacteria,2IEM0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3240013_2	1349767.GJA_2209	1.851e-161	522.0	28JJ9@1|root,2Z9CC@2|Bacteria,1R4HT@1224|Proteobacteria,2VNXY@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3240013_8	105559.Nwat_0320	6.329e-33	136.0	2C6TB@1|root,32RHR@2|Bacteria,1RKX5@1224|Proteobacteria,1SPS0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3240013_5	105559.Nwat_0320	2.467e-48	185.0	2C6TB@1|root,32RHR@2|Bacteria,1RKX5@1224|Proteobacteria,1SPS0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3240013_4	1267535.KB906767_gene4449	5.167e-108	364.0	COG0564@1|root,COG0564@2|Bacteria,3Y3G8@57723|Acidobacteria,2JHXC@204432|Acidobacteriia	204432|Acidobacteriia	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_3240013_3	234267.Acid_7266	2.176e-129	420.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
TLS2_k127_3240013_1	1267535.KB906767_gene4901	1.933e-172	546.0	COG0468@1|root,COG0468@2|Bacteria,3Y3Y1@57723|Acidobacteria,2JHU1@204432|Acidobacteriia	204432|Acidobacteriia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TLS2_k127_3240013_7	1122221.JHVI01000014_gene1364	2.167e-36	151.0	COG0457@1|root,COG0457@2|Bacteria	1122221.JHVI01000014_gene1364|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3240013_0	234267.Acid_5892	7.391e-177	565.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	B12-binding,Radical_SAM
TLS2_k127_3241279_0	1121957.ATVL01000007_gene2063	2.655e-235	744.0	COG3534@1|root,COG3534@2|Bacteria,4NGKW@976|Bacteroidetes,47NDB@768503|Cytophagia	976|Bacteroidetes	G	Alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C,CBM_4_9
TLS2_k127_3241279_1	234267.Acid_1003	6.069e-120	389.0	COG2407@1|root,COG2407@2|Bacteria,3Y63P@57723|Acidobacteria	57723|Acidobacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3258523_5	1287276.X752_19375	0.0008134	46.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS2_k127_3258523_3	234267.Acid_1624	4.55e-18	90.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
TLS2_k127_3258523_4	234267.Acid_0942	1.66e-12	74.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
TLS2_k127_3258523_1	1340493.JNIF01000004_gene530	3.008e-48	182.0	COG0526@1|root,COG0526@2|Bacteria,3Y4UN@57723|Acidobacteria	57723|Acidobacteria	CO	PFAM Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_3258523_0	234267.Acid_1055	7.383e-236	740.0	COG0277@1|root,COG0277@2|Bacteria,3Y68N@57723|Acidobacteria	57723|Acidobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_3258523_2	1122919.KB905555_gene888	7.836e-44	166.0	COG2032@1|root,COG2032@2|Bacteria,1V3HM@1239|Firmicutes,4HHM6@91061|Bacilli,26YB1@186822|Paenibacillaceae	91061|Bacilli	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	yojM_2	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
TLS2_k127_3261714_1	530564.Psta_3547	1.634e-16	86.0	COG5607@1|root,COG5607@2|Bacteria,2J128@203682|Planctomycetes	203682|Planctomycetes	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
TLS2_k127_3261714_0	1210884.HG799472_gene14860	4.947e-50	187.0	COG2165@1|root,COG2165@2|Bacteria,2IYB7@203682|Planctomycetes	203682|Planctomycetes	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
TLS2_k127_3264224_0	1210884.HG799469_gene14163	7.331e-111	370.0	COG0666@1|root,COG1520@1|root,COG0666@2|Bacteria,COG1520@2|Bacteria,2J2A4@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TLS2_k127_3264224_1	234267.Acid_0880	3.548e-99	338.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_3265873_1	452637.Oter_1387	2.532e-79	267.0	COG4146@1|root,COG4146@2|Bacteria	2|Bacteria	S	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
TLS2_k127_3265873_0	1123269.NX02_07140	5.363e-208	655.0	COG2115@1|root,COG2115@2|Bacteria,1MXS2@1224|Proteobacteria,2TSG4@28211|Alphaproteobacteria,2K031@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the xylose isomerase family	xylA	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	-
TLS2_k127_3265873_2	1502850.FG91_01887	6.671e-67	233.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2TR7P@28211|Alphaproteobacteria,2K2MJ@204457|Sphingomonadales	204457|Sphingomonadales	G	FGGY family of carbohydrate kinases, C-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS2_k127_3266787_1	313628.LNTAR_22734	2.247e-29	127.0	COG3119@1|root,COG3119@2|Bacteria	313628.LNTAR_22734|-	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3266787_0	1123020.AUIE01000020_gene1075	3.35e-123	402.0	COG2040@1|root,COG2040@2|Bacteria,1MUXU@1224|Proteobacteria,1SBT6@1236|Gammaproteobacteria,1YJ09@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Homocysteine S-methyltransferase	-	-	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	-	R00650	RC00003,RC00035	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
TLS2_k127_3266787_2	886293.Sinac_5029	3.322e-16	83.0	COG1878@1|root,COG1878@2|Bacteria,2IZXG@203682|Planctomycetes	203682|Planctomycetes	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_3267383_0	1121439.dsat_0488	1.053e-226	711.0	COG1858@1|root,COG1858@2|Bacteria,1N4E1@1224|Proteobacteria,43EW7@68525|delta/epsilon subdivisions,2WM9U@28221|Deltaproteobacteria,2MASI@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3267383_1	234267.Acid_1901	3.533e-84	281.0	COG0174@1|root,COG0174@2|Bacteria,3Y2P8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Glutamine synthetase, catalytic	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS2_k127_3270529_1	452637.Oter_4108	1.374e-65	228.0	COG0427@1|root,COG0427@2|Bacteria,46TQC@74201|Verrucomicrobia,3K7AC@414999|Opitutae	414999|Opitutae	C	acetyl-CoA hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
TLS2_k127_3270529_0	234267.Acid_6954	6.941e-141	455.0	COG1703@1|root,COG1703@2|Bacteria,3Y40X@57723|Acidobacteria	2|Bacteria	E	ArgK protein	argK	GO:0003674,GO:0003824,GO:0003924,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS2_k127_3270529_2	234267.Acid_6955	7.41e-61	211.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria	2|Bacteria	I	cobalamin binding	mutB	-	5.4.99.2	ko:K01847,ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
TLS2_k127_3271126_4	204669.Acid345_2431	7.39e-16	78.0	COG2605@1|root,COG2605@2|Bacteria,3Y56A@57723|Acidobacteria,2JP24@204432|Acidobacteriia	204432|Acidobacteriia	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_3271126_3	1340493.JNIF01000003_gene2959	6.112e-69	244.0	COG1266@1|root,COG1266@2|Bacteria,3Y4ED@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_3271126_2	234267.Acid_7366	5.083e-88	297.0	2D61V@1|root,32TKB@2|Bacteria,3Y5CF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3271126_0	1267535.KB906767_gene4952	1.855e-173	548.0	COG0057@1|root,COG0057@2|Bacteria,3Y2QC@57723|Acidobacteria,2JI8H@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TLS2_k127_3271126_5	1379270.AUXF01000002_gene1613	3.934e-07	57.0	2DD36@1|root,2ZGAH@2|Bacteria,1ZU63@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3271126_1	344747.PM8797T_06380	7.187e-123	402.0	COG0388@1|root,COG0388@2|Bacteria,2IXSE@203682|Planctomycetes	203682|Planctomycetes	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS2_k127_3291248_2	344747.PM8797T_00644	6.948e-58	209.0	COG2010@1|root,COG2010@2|Bacteria,2IWY5@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PA14,PSCyt1,PSCyt2,PSD1
TLS2_k127_3291248_0	1340493.JNIF01000003_gene2461	8.329e-126	414.0	COG3503@1|root,COG3503@2|Bacteria	2|Bacteria	J	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF418
TLS2_k127_3291248_1	1121904.ARBP01000007_gene3114	3.596e-61	211.0	COG4948@1|root,COG4948@2|Bacteria,4NIIJ@976|Bacteroidetes,47K75@768503|Cytophagia	976|Bacteroidetes	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_3294381_3	234267.Acid_4459	7.139e-100	346.0	COG0079@1|root,COG0079@2|Bacteria,3Y3Q8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_3294381_2	234267.Acid_4004	1.087e-102	343.0	COG1192@1|root,COG1192@2|Bacteria	2|Bacteria	D	plasmid maintenance	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
TLS2_k127_3294381_1	1340493.JNIF01000003_gene2935	2.074e-106	351.0	COG0179@1|root,COG0179@2|Bacteria,3Y6BP@57723|Acidobacteria	57723|Acidobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	4.2.1.141	ko:K14259	ko00040,map00040	-	R09186	RC00429	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
TLS2_k127_3294381_8	1210884.HG799462_gene8794	0.0001056	49.0	COG4191@1|root,COG4191@2|Bacteria,2J2PC@203682|Planctomycetes	203682|Planctomycetes	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
TLS2_k127_3294381_7	234267.Acid_6066	3.386e-08	61.0	COG0745@1|root,COG0745@2|Bacteria	234267.Acid_6066|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3294381_5	330214.NIDE3247	8.38e-56	203.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
TLS2_k127_3294381_6	1298867.AUES01000060_gene4719	3.97e-14	84.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,2TS2A@28211|Alphaproteobacteria,3JS1R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_16,TPR_7
TLS2_k127_3294381_4	1267535.KB906767_gene3247	2.037e-88	297.0	COG0546@1|root,COG0546@2|Bacteria,3Y7CE@57723|Acidobacteria	57723|Acidobacteria	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_3294381_0	1267535.KB906767_gene3168	2.95e-302	938.0	COG0465@1|root,COG0465@2|Bacteria,3Y2UK@57723|Acidobacteria,2JI9D@204432|Acidobacteriia	204432|Acidobacteriia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TLS2_k127_3294744_5	234267.Acid_1411	3.963e-70	253.0	COG4963@1|root,COG4963@2|Bacteria,3Y44H@57723|Acidobacteria	57723|Acidobacteria	U	AAA domain	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
TLS2_k127_3294744_0	234267.Acid_1412	1.51e-193	614.0	COG4962@1|root,COG4962@2|Bacteria,3Y360@57723|Acidobacteria	57723|Acidobacteria	U	PFAM type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS2_k127_3294744_4	234267.Acid_1413	1.053e-72	262.0	COG4965@1|root,COG4965@2|Bacteria,3Y4RR@57723|Acidobacteria	57723|Acidobacteria	U	type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_3294744_6	1340493.JNIF01000003_gene3299	7.253e-68	245.0	COG2064@1|root,COG2064@2|Bacteria,3Y4FI@57723|Acidobacteria	57723|Acidobacteria	NU	type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_3294744_11	234267.Acid_2221	2.831e-25	112.0	COG1989@1|root,COG1989@2|Bacteria,3Y9FS@57723|Acidobacteria	57723|Acidobacteria	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02278	-	-	-	-	ko00000,ko01000,ko02035,ko02044	-	-	-	Peptidase_A24
TLS2_k127_3294744_12	234267.Acid_5392	6.916e-25	108.0	2CTSB@1|root,32SU2@2|Bacteria,3Y567@57723|Acidobacteria	57723|Acidobacteria	S	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_3294744_14	401053.AciPR4_0456	4.012e-11	66.0	arCOG13401@1|root,33MMV@2|Bacteria,3Y5TE@57723|Acidobacteria,2JNR5@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
TLS2_k127_3294744_10	1267535.KB906767_gene3989	5.079e-32	128.0	2FK9P@1|root,34BXB@2|Bacteria,3Y8F7@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3294744_3	234267.Acid_1565	3.649e-93	309.0	COG0302@1|root,COG0302@2|Bacteria,3Y2SP@57723|Acidobacteria	57723|Acidobacteria	H	PFAM GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
TLS2_k127_3294744_9	1267535.KB906767_gene3987	1.03e-37	146.0	COG0720@1|root,COG0720@2|Bacteria,3Y56Y@57723|Acidobacteria,2JJNB@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM 6-pyruvoyl tetrahydropterin	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
TLS2_k127_3294744_8	1267535.KB906767_gene3986	1.37e-53	192.0	COG0720@1|root,COG0720@2|Bacteria,3Y4K2@57723|Acidobacteria,2JJD0@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM 6-pyruvoyl tetrahydropterin	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
TLS2_k127_3294744_2	234267.Acid_2809	9.428e-100	330.0	COG0566@1|root,COG0566@2|Bacteria,3Y3XM@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS2_k127_3294744_1	234267.Acid_7736	3.215e-182	595.0	COG4206@1|root,COG4206@2|Bacteria	2|Bacteria	H	cobalamin-transporting ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug
TLS2_k127_3294744_7	1288494.EBAPG3_17430	3.165e-54	216.0	COG0642@1|root,COG0745@1|root,COG2203@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJI1@28216|Betaproteobacteria,372K3@32003|Nitrosomonadales	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
TLS2_k127_3294744_13	1040989.AWZU01000007_gene781	3.316e-13	83.0	COG0642@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,3JV46@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Pkinase,Response_reg
TLS2_k127_3295407_1	1267535.KB906767_gene3869	1.343e-31	133.0	COG3637@1|root,COG3637@2|Bacteria,3Y783@57723|Acidobacteria	57723|Acidobacteria	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TLS2_k127_3295407_0	1267535.KB906767_gene4853	0.0	1101.0	COG1274@1|root,COG1274@2|Bacteria,3Y2IH@57723|Acidobacteria,2JIZH@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
TLS2_k127_3295420_0	234267.Acid_0673	1.172e-149	484.0	COG2271@1|root,COG2271@2|Bacteria,3Y3W5@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_3295420_1	1382359.JIAL01000001_gene2834	2.71e-39	150.0	COG3684@1|root,COG3684@2|Bacteria,3Y33H@57723|Acidobacteria,2JIH2@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase	-	-	4.1.2.40	ko:K01635	ko00052,ko01100,ko02024,map00052,map01100,map02024	-	R01069	RC00438,RC00439	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS2_k127_3300489_5	1340493.JNIF01000003_gene3144	1.381e-64	227.0	COG0845@1|root,COG0845@2|Bacteria,3Y3S2@57723|Acidobacteria	57723|Acidobacteria	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TLS2_k127_3300489_0	1340493.JNIF01000003_gene3145	0.0	1695.0	COG0841@1|root,COG0841@2|Bacteria,3Y309@57723|Acidobacteria	57723|Acidobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TLS2_k127_3300489_2	1340493.JNIF01000003_gene3146	6.928e-152	493.0	COG1538@1|root,COG1538@2|Bacteria,3Y3KB@57723|Acidobacteria	57723|Acidobacteria	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS2_k127_3300489_6	1340493.JNIF01000003_gene3147	5.755e-46	168.0	COG1695@1|root,COG1695@2|Bacteria,3Y5GY@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_3300489_4	1218076.BAYB01000055_gene6144	1.292e-85	294.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2VJHK@28216|Betaproteobacteria,1K52I@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Methyltransferase	egtD	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
TLS2_k127_3300489_3	1267535.KB906767_gene1504	2.028e-120	398.0	COG1262@1|root,COG1262@2|Bacteria,3Y3U7@57723|Acidobacteria	57723|Acidobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
TLS2_k127_3300489_1	234267.Acid_0409	0.0	1210.0	COG0058@1|root,COG0058@2|Bacteria,3Y65H@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glycosyl transferase, family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
TLS2_k127_3313575_0	1123242.JH636435_gene1359	1.245e-219	693.0	COG0129@1|root,COG0129@2|Bacteria,2IYTK@203682|Planctomycetes	203682|Planctomycetes	EG	Dehydratase family	-	-	4.2.1.82	ko:K22186	ko00040,map00040	-	R02429	RC00543	ko00000,ko00001,ko01000	-	-	-	ILVD_EDD
TLS2_k127_3313575_1	448385.sce2508	1.563e-111	370.0	COG0475@1|root,COG0589@1|root,COG0475@2|Bacteria,COG0589@2|Bacteria,1MVGV@1224|Proteobacteria,42WJ6@68525|delta/epsilon subdivisions,2WQ9K@28221|Deltaproteobacteria,2YXTM@29|Myxococcales	28221|Deltaproteobacteria	PT	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,Usp
TLS2_k127_3315619_3	2880.D7FGT0	0.0002039	47.0	COG0457@1|root,KOG1840@2759|Eukaryota	2759|Eukaryota	C	determination of stomach left/right asymmetry	-	-	-	ko:K10407	ko05132,map05132	-	-	-	ko00000,ko00001,ko03019,ko04812	-	-	-	NB-ARC,TPR_10,TPR_12,TPR_16,TPR_4,TPR_7,TPR_8
TLS2_k127_3315619_0	234267.Acid_2456	4.161e-188	619.0	COG0577@1|root,COG0577@2|Bacteria,3Y6MX@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_3315619_1	234267.Acid_6791	1.529e-84	287.0	COG4974@1|root,COG4974@2|Bacteria,3Y73V@57723|Acidobacteria	57723|Acidobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_3315619_2	234267.Acid_6791	6.993e-29	118.0	COG4974@1|root,COG4974@2|Bacteria,3Y73V@57723|Acidobacteria	57723|Acidobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_3320057_3	234267.Acid_6618	1.281e-19	93.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	GNVR,Wzz
TLS2_k127_3320057_1	234267.Acid_6617	6.422e-115	392.0	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	ko:K02847	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	Wzy_C
TLS2_k127_3320057_0	234267.Acid_6634	1.248e-150	485.0	COG0438@1|root,COG0438@2|Bacteria,3Y647@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_3320057_2	234267.Acid_2144	6.46e-24	104.0	COG2318@1|root,COG2318@2|Bacteria,3Y7B7@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
TLS2_k127_3323857_3	639030.JHVA01000001_gene1889	5.036e-05	45.0	COG1629@1|root,COG4771@2|Bacteria,3Y9D4@57723|Acidobacteria,2JP0W@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_3323857_2	1267534.KB906754_gene2950	8.974e-07	54.0	COG3485@1|root,COG3485@2|Bacteria,3Y3VM@57723|Acidobacteria,2JHSQ@204432|Acidobacteriia	2|Bacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Dioxygenase_C,TonB_dep_Rec
TLS2_k127_3323857_1	401053.AciPR4_0638	5.403e-21	99.0	COG1629@1|root,COG4771@2|Bacteria,3Y3Y0@57723|Acidobacteria,2JIYU@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_3323857_0	344747.PM8797T_19819	1.006e-132	434.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_3332305_0	1267535.KB906767_gene2547	4.775e-125	416.0	COG1807@1|root,COG1807@2|Bacteria,3Y2UV@57723|Acidobacteria,2JIS6@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_3332305_4	1267535.KB906767_gene2546	5.015e-37	141.0	2E8MJ@1|root,32S5J@2|Bacteria,3Y53W@57723|Acidobacteria,2JNZ2@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF3467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3467
TLS2_k127_3332305_5	926560.KE387023_gene1140	1.156e-29	124.0	COG2318@1|root,COG2318@2|Bacteria,1WMTV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_3332305_1	1267535.KB906767_gene4864	5.535e-89	306.0	COG4977@1|root,COG4977@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	3.2.2.1,4.2.1.103	ko:K01239,ko:K02855,ko:K07506,ko:K18199	ko00230,ko00760,ko00930,ko01100,map00230,map00760,map00930,map01100	-	R01245,R01273,R01677,R01770,R02143,R05771	RC00033,RC00063,RC00122,RC00318,RC00485,RC01467	ko00000,ko00001,ko01000,ko01002,ko03000	-	-	-	AraC_binding_2,HTH_18
TLS2_k127_3332305_6	204669.Acid345_3953	5.743e-11	69.0	COG2318@1|root,COG2318@2|Bacteria,3Y6JD@57723|Acidobacteria,2JM5M@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_3332305_2	1278073.MYSTI_05731	3.175e-49	179.0	2CRBS@1|root,32SNS@2|Bacteria,1RAPW@1224|Proteobacteria	1224|Proteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_3332305_3	1210884.HG799472_gene14746	3.405e-46	168.0	COG1506@1|root,COG1506@2|Bacteria,2IYT8@203682|Planctomycetes	203682|Planctomycetes	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
TLS2_k127_3335440_1	1267535.KB906767_gene889	4.226e-22	100.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	ermC	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31,Ubie_methyltran
TLS2_k127_3335440_0	1280948.HY36_06195	3.378e-62	225.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,43WQS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	MA20_17095	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_3337978_0	278963.ATWD01000001_gene1304	0.0	1105.0	COG1629@1|root,COG4771@2|Bacteria,3Y477@57723|Acidobacteria,2JHX2@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_3341967_0	929562.Emtol_4141	2.846e-141	456.0	COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,47NH0@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_3341967_2	485916.Dtox_2291	2.098e-11	75.0	COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia,260ZP@186807|Peptococcaceae	186801|Clostridia	S	PFAM aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
TLS2_k127_3341967_1	1340493.JNIF01000003_gene1826	6.621e-68	250.0	COG3379@1|root,COG3379@2|Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Phosphodiest
TLS2_k127_334369_2	1045855.DSC_14970	2.082e-42	158.0	2DG5Q@1|root,2ZUMM@2|Bacteria,1P8DT@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_334369_0	572477.Alvin_2964	1.359e-256	796.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1WVZP@135613|Chromatiales	135613|Chromatiales	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
TLS2_k127_334369_3	163164.WD_0880	5.64e-09	65.0	COG5424@1|root,COG5424@2|Bacteria,1PV6D@1224|Proteobacteria,2V6N7@28211|Alphaproteobacteria,47F6F@766|Rickettsiales	766|Rickettsiales	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2
TLS2_k127_334369_1	1415780.JPOG01000001_gene2256	5.583e-56	205.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1X55Z@135614|Xanthomonadales	135614|Xanthomonadales	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM,SLT
TLS2_k127_3350556_1	1267533.KB906737_gene1715	3.829e-58	208.0	COG2197@1|root,COG2197@2|Bacteria,3Y4DR@57723|Acidobacteria,2JJ2N@204432|Acidobacteriia	204432|Acidobacteriia	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_3350556_3	1403819.BATR01000114_gene3999	3.078e-25	110.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_3350556_0	1210884.HG799475_gene15229	1.713e-91	319.0	COG3119@1|root,COG3119@2|Bacteria,2IYGF@203682|Planctomycetes	203682|Planctomycetes	P	Domain of unknown function (DUF4976)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_3350556_2	234267.Acid_2974	9.133e-48	184.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_3351664_0	710696.Intca_1953	1.169e-29	124.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4FE61@85021|Intrasporangiaceae	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
TLS2_k127_3351664_2	525909.Afer_0682	9.455e-06	53.0	2ERJT@1|root,33J59@2|Bacteria,2HGGQ@201174|Actinobacteria,4CNDW@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3040
TLS2_k127_3351664_1	1122994.AUFR01000015_gene1824	8.777e-24	108.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,4DPQ2@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_3355788_3	113355.CM001775_gene1908	2.461e-05	49.0	COG3744@1|root,COG3744@2|Bacteria,1G8VX@1117|Cyanobacteria	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_3355788_0	694430.Natoc_3739	5.298e-59	216.0	COG0508@1|root,arCOG01706@2157|Archaea,2XUGY@28890|Euryarchaeota,23V33@183963|Halobacteria	183963|Halobacteria	C	COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
TLS2_k127_3355788_2	234267.Acid_2583	5.252e-52	186.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	gloA	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_3355788_1	1123242.JH636435_gene2360	7.475e-56	200.0	COG1520@1|root,COG1520@2|Bacteria,2IXST@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_3363340_1	383372.Rcas_1067	1.642e-79	271.0	COG0259@1|root,COG0259@2|Bacteria,2G8DA@200795|Chloroflexi,376ZA@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	-	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
TLS2_k127_3363340_2	56780.SYN_03131	1.892e-55	198.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42T3J@68525|delta/epsilon subdivisions,2X5P0@28221|Deltaproteobacteria,2MRWT@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
TLS2_k127_3363340_3	234267.Acid_0242	3.534e-42	156.0	COG4104@1|root,COG4104@2|Bacteria,3Y5VI@57723|Acidobacteria	57723|Acidobacteria	S	PAAR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PAAR_motif
TLS2_k127_3363340_4	234267.Acid_0241	8.493e-29	125.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	ko:K11894	-	-	-	-	ko00000,ko02044	3.A.23.1	-	-	DUF3662,FHA
TLS2_k127_3363340_0	886293.Sinac_2402	4.886e-149	494.0	COG3501@1|root,COG3501@2|Bacteria,2IWY7@203682|Planctomycetes	203682|Planctomycetes	Q	TIGRFAM type VI secretion system Vgr family protein	-	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	Phage_GPD
TLS2_k127_3363340_5	329726.AM1_3186	2.41e-12	72.0	COG2931@1|root,COG2931@2|Bacteria,1G1I0@1117|Cyanobacteria	1117|Cyanobacteria	Q	Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS2_k127_3366922_1	234267.Acid_7405	3.245e-37	143.0	COG2084@1|root,COG2084@2|Bacteria	2|Bacteria	I	phosphogluconate dehydrogenase (decarboxylating) activity	mmsB	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_3366922_0	1382359.JIAL01000001_gene1871	6.478e-119	420.0	COG1629@1|root,COG4771@2|Bacteria,3Y3P9@57723|Acidobacteria,2JHUB@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_3366922_2	743722.Sph21_2661	1.893e-31	132.0	COG4122@1|root,COG4122@2|Bacteria,4PBU0@976|Bacteroidetes,1IZHJ@117747|Sphingobacteriia	976|Bacteroidetes	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
TLS2_k127_3375115_0	234267.Acid_4916	0.0	1043.0	COG1629@1|root,COG4771@2|Bacteria,3Y9AT@57723|Acidobacteria	57723|Acidobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_3375115_1	234267.Acid_1336	6.546e-228	713.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,TAT_signal
TLS2_k127_3375115_2	945713.IALB_0988	8.586e-222	697.0	COG2978@1|root,COG2978@2|Bacteria	2|Bacteria	H	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity	ydaH	-	-	ko:K12942	-	-	-	-	ko00000	-	-	-	ABG_transport
TLS2_k127_3375115_3	234267.Acid_7422	2.668e-67	242.0	COG0615@1|root,COG0615@2|Bacteria,3Y5F4@57723|Acidobacteria	57723|Acidobacteria	IM	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
TLS2_k127_3375115_4	1267535.KB906767_gene1342	2.008e-10	64.0	COG1197@1|root,COG1197@2|Bacteria,3Y3IE@57723|Acidobacteria,2JIHQ@204432|Acidobacteriia	204432|Acidobacteriia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS2_k127_3375213_0	309801.trd_1801	7.235e-17	95.0	COG4485@1|root,COG4485@2|Bacteria,2G75F@200795|Chloroflexi,27XT2@189775|Thermomicrobia	189775|Thermomicrobia	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
TLS2_k127_3375726_0	1267535.KB906767_gene1103	8.258e-102	334.0	COG0745@1|root,COG0745@2|Bacteria	1267535.KB906767_gene1103|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3375726_1	246197.MXAN_4249	4.31e-101	344.0	COG2823@1|root,COG5637@1|root,COG2823@2|Bacteria,COG5637@2|Bacteria,1RI3F@1224|Proteobacteria,437A8@68525|delta/epsilon subdivisions,2X2EK@28221|Deltaproteobacteria,2YVIY@29|Myxococcales	28221|Deltaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TLS2_k127_3375726_3	935557.ATYB01000009_gene798	2.483e-26	120.0	COG2823@1|root,COG2823@2|Bacteria,1N1R4@1224|Proteobacteria,2UDII@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS2_k127_3375726_4	1382359.JIAL01000001_gene990	5.158e-18	88.0	2FB7S@1|root,343E0@2|Bacteria,3Y8FG@57723|Acidobacteria,2JNJF@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3375726_2	234267.Acid_0872	1.081e-90	330.0	COG1629@1|root,COG4771@2|Bacteria,3Y2QR@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_3381913_8	1121344.JHZO01000004_gene1534	3.27e-05	56.0	COG1404@1|root,COG1404@2|Bacteria,1VCZR@1239|Firmicutes,24F97@186801|Clostridia	186801|Clostridia	O	Intracellular proteinase inhibitor	-	-	-	-	-	-	-	-	-	-	-	-	BsuPI,SLH
TLS2_k127_3381913_2	1267535.KB906767_gene5103	6.967e-142	458.0	COG0667@1|root,COG0667@2|Bacteria,3Y2TN@57723|Acidobacteria,2JMH3@204432|Acidobacteriia	204432|Acidobacteriia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_3381913_5	234267.Acid_5140	8.731e-68	239.0	28IJE@1|root,2Z8KB@2|Bacteria,3Y46I@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3381913_4	1267535.KB906767_gene3126	1.421e-119	394.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_3381913_0	1340493.JNIF01000003_gene2993	3.412e-256	801.0	COG0442@1|root,COG0442@2|Bacteria,3Y329@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
TLS2_k127_3381913_6	234267.Acid_7018	7.377e-43	165.0	COG0698@1|root,COG0698@2|Bacteria,3Y5FG@57723|Acidobacteria	57723|Acidobacteria	G	Ribose/Galactose Isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
TLS2_k127_3381913_1	1267535.KB906767_gene3125	5.522e-214	671.0	COG0112@1|root,COG0112@2|Bacteria,3Y2JB@57723|Acidobacteria,2JI87@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TLS2_k127_3381913_3	1340493.JNIF01000003_gene2991	1.601e-139	452.0	COG0438@1|root,COG0438@2|Bacteria,3Y58K@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_3381913_7	234267.Acid_2717	3.513e-14	81.0	28TDW@1|root,2ZFN7@2|Bacteria,3Y8WA@57723|Acidobacteria	57723|Acidobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3387393_5	1254432.SCE1572_30125	5.983e-13	72.0	COG3437@1|root,COG3829@1|root,COG3852@1|root,COG4251@1|root,COG3437@2|Bacteria,COG3829@2|Bacteria,COG3852@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,43CDW@68525|delta/epsilon subdivisions,2X7X2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
TLS2_k127_3387393_0	1128421.JAGA01000002_gene1203	5.294e-122	402.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_3387393_1	344747.PM8797T_22883	4.251e-115	391.0	COG0451@1|root,COG0451@2|Bacteria,2IYNU@203682|Planctomycetes	203682|Planctomycetes	M	COG0451 Nucleoside-diphosphate-sugar	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS2_k127_3387393_2	756272.Plabr_4457	9.724e-77	261.0	COG0451@1|root,COG0451@2|Bacteria,2IZ4B@203682|Planctomycetes	203682|Planctomycetes	GM	Vitamin K epoxide reductase family	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
TLS2_k127_3387393_4	344747.PM8797T_22873	3.414e-15	79.0	2E8F6@1|root,332TI@2|Bacteria,2J0NF@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SPW
TLS2_k127_3387393_3	234267.Acid_3692	2.358e-32	132.0	COG2304@1|root,COG2304@2|Bacteria,3Y44P@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_3394158_1	1120977.JHUX01000004_gene2398	7.101e-14	74.0	COG1403@1|root,COG1403@2|Bacteria,1NBAA@1224|Proteobacteria,1SDU9@1236|Gammaproteobacteria,3NPJ7@468|Moraxellaceae	1236|Gammaproteobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
TLS2_k127_3394158_2	1347369.CCAD010000083_gene2768	0.0006046	44.0	COG1403@1|root,COG1403@2|Bacteria,1VFR5@1239|Firmicutes,4HQB5@91061|Bacilli,1ZICY@1386|Bacillus	91061|Bacilli	V	COG1403 Restriction endonuclease	yisB	-	-	-	-	-	-	-	-	-	-	-	HNH
TLS2_k127_3394158_0	234267.Acid_3831	2.529e-31	128.0	2FD54@1|root,3457B@2|Bacteria,3Y8HH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3404147_0	1211114.ALIP01000037_gene115	2.437e-235	739.0	COG3507@1|root,COG3507@2|Bacteria,1NNX4@1224|Proteobacteria,1RYTM@1236|Gammaproteobacteria,1X3YP@135614|Xanthomonadales	135614|Xanthomonadales	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.37,3.2.1.55	ko:K01198,ko:K01209	ko00520,ko01100,map00520,map01100	-	R01433,R01762	RC00467	ko00000,ko00001,ko01000	-	GH43,GH51	-	Glyco_hydro_43
TLS2_k127_3404147_1	452637.Oter_4329	3.88e-199	635.0	COG0673@1|root,COG0673@2|Bacteria,46TMZ@74201|Verrucomicrobia,3K8Y2@414999|Opitutae	414999|Opitutae	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_3404147_2	861299.J421_2227	4.195e-171	550.0	COG0673@1|root,COG3828@1|root,COG0673@2|Bacteria,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	3.2.1.130,3.2.1.198	ko:K15538,ko:K21132	-	-	-	-	ko00000,ko01000	-	GH99	-	Glyco_hydro_99,Oxidoreduct_C,PmoA,VCBS
TLS2_k127_3404147_3	497964.CfE428DRAFT_6451	8.119e-43	162.0	COG1917@1|root,COG1917@2|Bacteria,46VBI@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_3404147_4	450380.JPSY01000001_gene1230	1.682e-24	103.0	COG1023@1|root,COG1023@2|Bacteria,2I2DH@201174|Actinobacteria,4FMVS@85023|Microbacteriaceae	201174|Actinobacteria	G	6-phosphogluconate dehydrogenase, C-terminal domain	gnd2	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1122	6PGD,NAD_binding_2
TLS2_k127_3415148_0	1267535.KB906767_gene1102	3.055e-140	462.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_3415148_1	1267535.KB906767_gene1101	1.921e-91	305.0	COG3880@1|root,COG3880@2|Bacteria,3Y2KG@57723|Acidobacteria,2JHTD@204432|Acidobacteriia	57723|Acidobacteria	S	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
TLS2_k127_3415148_2	1267535.KB906767_gene1100	1.532e-38	149.0	COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria,2JI83@204432|Acidobacteriia	204432|Acidobacteriia	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
TLS2_k127_341523_3	530564.Psta_3282	5.721e-112	373.0	COG0282@1|root,COG0282@2|Bacteria,2IXZC@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
TLS2_k127_341523_2	452637.Oter_2055	3.451e-116	389.0	COG4656@1|root,COG4656@2|Bacteria,46W83@74201|Verrucomicrobia	74201|Verrucomicrobia	C	RnfC Barrel sandwich hybrid domain	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,Fer4_17,RnfC_N,SLBB
TLS2_k127_341523_4	880073.Calab_1627	7.222e-44	166.0	COG4577@1|root,COG4577@2|Bacteria,2NRES@2323|unclassified Bacteria	2|Bacteria	CQ	BMC	-	-	-	ko:K04025	-	-	-	-	ko00000	-	-	-	BMC
TLS2_k127_341523_0	1411123.JQNH01000001_gene2221	4.468e-123	401.0	COG3546@1|root,COG3546@2|Bacteria,1R6EN@1224|Proteobacteria,2TRQJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	PFAM Manganese containing catalase	-	-	-	-	-	-	-	-	-	-	-	-	Mn_catalase
TLS2_k127_341523_1	234267.Acid_0193	6.082e-123	407.0	COG4409@1|root,COG4409@2|Bacteria,3Y7HZ@57723|Acidobacteria	57723|Acidobacteria	G	BNR repeat-like domain	-	-	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2
TLS2_k127_3423352_1	697281.Mahau_1207	9.455e-64	228.0	COG2730@1|root,COG2730@2|Bacteria,1V9GI@1239|Firmicutes,24KYA@186801|Clostridia	186801|Clostridia	G	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
TLS2_k127_3423352_0	697281.Mahau_1207	9.792e-173	559.0	COG2730@1|root,COG2730@2|Bacteria,1V9GI@1239|Firmicutes,24KYA@186801|Clostridia	186801|Clostridia	G	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
TLS2_k127_3423352_4	1236514.BAKL01000001_gene57	3.194e-19	89.0	COG3119@1|root,COG3119@2|Bacteria,4NF1X@976|Bacteroidetes,2FP6T@200643|Bacteroidia,4AKST@815|Bacteroidaceae	976|Bacteroidetes	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_3423352_2	1249627.D779_0096	5.405e-37	147.0	2CFP1@1|root,32UTJ@2|Bacteria,1N7ZD@1224|Proteobacteria	1224|Proteobacteria	S	Calcium binding	-	-	-	-	-	-	-	-	-	-	-	-	Calci_bind_CcbP
TLS2_k127_3423352_3	234267.Acid_6125	1.858e-19	91.0	COG1961@1|root,COG1961@2|Bacteria,3Y5HT@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_7,Resolvase
TLS2_k127_3423352_5	658187.LDG_5780	1.393e-10	64.0	COG1961@1|root,COG1961@2|Bacteria,1RA0V@1224|Proteobacteria,1RPSK@1236|Gammaproteobacteria,1JGHE@118969|Legionellales	118969|Legionellales	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Resolvase
TLS2_k127_3431009_4	1196322.A370_05537	2.819e-07	55.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	MethyTransf_Reg,Methyltransf_23,Methyltransf_25,Methyltransf_31
TLS2_k127_3431009_3	511062.GU3_14735	8.559e-09	67.0	2DTSS@1|root,33MHM@2|Bacteria,1NJRN@1224|Proteobacteria,1SQ26@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3431009_1	1123508.JH636439_gene1039	1.445e-67	244.0	COG0500@1|root,COG2226@2|Bacteria,2J1GI@203682|Planctomycetes	203682|Planctomycetes	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_3431009_0	1121904.ARBP01000001_gene5755	1.237e-68	243.0	COG4122@1|root,COG4122@2|Bacteria,4NP2A@976|Bacteroidetes,47SZD@768503|Cytophagia	976|Bacteroidetes	S	Macrocin-O-methyltransferase (TylF)	-	-	-	-	-	-	-	-	-	-	-	-	TylF
TLS2_k127_3431009_2	1134912.AJTV01000022_gene2967	6.766e-10	72.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25
TLS2_k127_3431040_1	648757.Rvan_3380	1.916e-45	168.0	COG1511@1|root,COG1511@2|Bacteria,1NYJB@1224|Proteobacteria,2TSX0@28211|Alphaproteobacteria,3N6Q5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	MotA TolQ ExbB proton channel family	MA20_18055	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
TLS2_k127_3431040_0	1320556.AVBP01000009_gene2536	6.313e-122	399.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,2TQKZ@28211|Alphaproteobacteria,43IFN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	N	Flagellar motor protein	MA20_18060	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
TLS2_k127_3431040_2	384765.SIAM614_14063	1.539e-26	113.0	COG1734@1|root,COG1734@2|Bacteria,1N7D8@1224|Proteobacteria,2UHGM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG1734 DnaK suppressor protein	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
TLS2_k127_3437640_1	234267.Acid_5424	2.779e-38	151.0	COG1566@1|root,COG1566@2|Bacteria	2|Bacteria	V	PFAM secretion protein HlyD family protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
TLS2_k127_3437640_0	234267.Acid_5423	7.636e-267	827.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,3Y4NM@57723|Acidobacteria	57723|Acidobacteria	C	Fumarate hydratase (Fumerase)	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
TLS2_k127_3451217_0	1254432.SCE1572_10115	1.866e-143	462.0	COG4277@1|root,COG4277@2|Bacteria,1MVCV@1224|Proteobacteria,42NNA@68525|delta/epsilon subdivisions,2WTR9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Helix-hairpin-helix DNA-binding motif class 1	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Radical_SAM
TLS2_k127_3451217_3	1267533.KB906737_gene1854	6.66e-54	193.0	COG4319@1|root,COG4319@2|Bacteria,3Y8GW@57723|Acidobacteria	57723|Acidobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_3451217_2	1267535.KB906767_gene3366	7.408e-91	302.0	COG0066@1|root,COG0066@2|Bacteria,3Y39B@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
TLS2_k127_3451217_1	1267535.KB906767_gene3365	1.153e-128	414.0	COG0065@1|root,COG0065@2|Bacteria,3Y2ID@57723|Acidobacteria,2JI0J@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TLS2_k127_3455613_14	1267534.KB906757_gene995	2.37e-07	53.0	COG1312@1|root,COG1312@2|Bacteria	2|Bacteria	G	mannonate dehydratase activity	uxuA	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
TLS2_k127_3455613_9	402881.Plav_0614	1.408e-63	233.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TSQ3@28211|Alphaproteobacteria,1JQ7T@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
TLS2_k127_3455613_3	1267535.KB906767_gene3453	1.461e-136	443.0	COG0673@1|root,COG0673@2|Bacteria,3Y4RG@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_3455613_1	1267535.KB906767_gene966	4.044e-197	626.0	COG2272@1|root,COG2272@2|Bacteria,3Y6S1@57723|Acidobacteria	57723|Acidobacteria	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
TLS2_k127_3455613_2	234267.Acid_2729	4.595e-139	452.0	28K3C@1|root,2Z9SH@2|Bacteria,3Y7UF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3455613_7	234267.Acid_2730	1.896e-108	362.0	28PTH@1|root,2ZCER@2|Bacteria,3Y860@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3455613_8	234267.Acid_2733	1.428e-78	273.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	-
TLS2_k127_3455613_12	639030.JHVA01000001_gene2645	2.513e-30	129.0	COG1695@1|root,COG1695@2|Bacteria,3Y4XK@57723|Acidobacteria,2JJR3@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_3455613_6	234267.Acid_4442	8.215e-129	447.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_3455613_5	1267535.KB906767_gene1477	6.426e-129	418.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,GDP_Man_Dehyd
TLS2_k127_3455613_0	1267535.KB906767_gene1476	1.284e-198	626.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_3455613_10	1340493.JNIF01000003_gene4158	5.24e-62	219.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS2_k127_3455613_11	234267.Acid_6765	3.533e-33	134.0	COG1314@1|root,COG1314@2|Bacteria,3Y56S@57723|Acidobacteria	57723|Acidobacteria	U	Preprotein translocase SecG subunit	-	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
TLS2_k127_3455613_13	1121396.KB893121_gene3060	6.071e-25	108.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,42Q95@68525|delta/epsilon subdivisions,2WKM2@28221|Deltaproteobacteria,2MIMV@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_5,Phage_integrase
TLS2_k127_3464417_1	420662.Mpe_A0604	1.024e-72	258.0	COG1215@1|root,COG1215@2|Bacteria,1NDPE@1224|Proteobacteria,2VKEI@28216|Betaproteobacteria,1KN73@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_3464417_0	457398.HMPREF0326_00608	3.961e-76	267.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42NH8@68525|delta/epsilon subdivisions,2WJMA@28221|Deltaproteobacteria,2MA09@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS2_k127_3503437_6	935863.AWZR01000014_gene2989	2.311e-12	73.0	2EHSB@1|root,33BI2@2|Bacteria	2|Bacteria	S	SdpI/YhfL protein family	-	-	-	-	-	-	-	-	-	-	-	-	SdpI
TLS2_k127_3503437_1	756272.Plabr_3174	2.555e-135	445.0	COG3119@1|root,COG3119@2|Bacteria,2IYH5@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_3503437_0	1122605.KB893649_gene3749	1.422e-149	489.0	COG3119@1|root,COG3119@2|Bacteria,4NEQ5@976|Bacteroidetes,1IRRQ@117747|Sphingobacteriia	2|Bacteria	P	PFAM sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_3503437_3	158500.BV97_01284	1.569e-52	193.0	COG1793@1|root,COG1793@2|Bacteria,1QWEB@1224|Proteobacteria,2UFT7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_3503437_2	1340493.JNIF01000003_gene2866	2.78e-122	405.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_3503437_4	1340493.JNIF01000004_gene241	6.012e-44	167.0	COG1238@1|root,COG1238@2|Bacteria,3Y52F@57723|Acidobacteria	57723|Acidobacteria	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_3503437_5	762376.AXYL_01488	9.087e-33	129.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,3T1C7@506|Alcaligenaceae	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
TLS2_k127_3520835_5	246200.SPO1190	9.63e-32	128.0	COG1733@1|root,COG1733@2|Bacteria,1MZ6G@1224|Proteobacteria,2VAGK@28211|Alphaproteobacteria,4NCEF@97050|Ruegeria	28211|Alphaproteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS2_k127_3520835_2	485913.Krac_4367	7.028e-84	290.0	COG1028@1|root,COG1028@2|Bacteria	485913.Krac_4367|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3520835_6	448385.sce0990	3.138e-20	96.0	COG5470@1|root,COG5470@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
TLS2_k127_3520835_4	1121920.AUAU01000001_gene2244	6.253e-55	194.0	COG3631@1|root,COG3631@2|Bacteria	2|Bacteria	S	light absorption	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
TLS2_k127_3520835_0	1267535.KB906767_gene5141	2.386e-143	480.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria	57723|Acidobacteria	KU	WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_3520835_7	1120973.AQXL01000117_gene380	9.736e-13	78.0	28NT3@1|root,2ZBRV@2|Bacteria,1V1C2@1239|Firmicutes,4HFYQ@91061|Bacilli,27A60@186823|Alicyclobacillaceae	91061|Bacilli	S	YwiC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YwiC
TLS2_k127_3520835_3	1229203.KI301992_gene412	4.767e-56	202.0	COG0406@1|root,COG0406@2|Bacteria,2GNRS@201174|Actinobacteria	201174|Actinobacteria	G	Phosphoglycerate mutase	gpm2	GO:0003674,GO:0003824,GO:0003993,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0042802,GO:0042803,GO:0044237,GO:0046983	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TLS2_k127_3520835_1	234267.Acid_4749	4.762e-140	457.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_3520835_9	1340493.JNIF01000004_gene59	6.529e-07	59.0	COG5549@1|root,COG5549@2|Bacteria	2|Bacteria	O	protein import	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,Peptidase_M10
TLS2_k127_3529350_1	1227454.C446_04245	1.19e-29	131.0	COG1266@1|root,arCOG02768@2157|Archaea,2XZ3X@28890|Euryarchaeota,23WZT@183963|Halobacteria	183963|Halobacteria	S	metal-dependent membrane protease	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS2_k127_3529350_4	1408311.JNJM01000010_gene961	0.0001766	51.0	COG1403@1|root,COG1403@2|Bacteria,1VY9R@1239|Firmicutes,25PW0@186801|Clostridia,2PTHB@265975|Oribacterium	186801|Clostridia	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3529350_2	324602.Caur_3617	1.61e-23	108.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_3543481_2	448385.sce4884	6.665e-37	143.0	COG3507@1|root,COG3507@2|Bacteria,1NNX4@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.37,3.2.1.55	ko:K01198,ko:K01209	ko00520,ko01100,map00520,map01100	-	R01433,R01762	RC00467	ko00000,ko00001,ko01000	-	GH43,GH51	-	Glyco_hydro_43
TLS2_k127_3543481_0	1123368.AUIS01000010_gene2370	7.854e-48	181.0	COG4798@1|root,COG4798@2|Bacteria,1QUNP@1224|Proteobacteria,1S3N0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_3543481_1	1118235.CAJH01000062_gene3456	9.322e-41	155.0	COG2222@1|root,COG2222@2|Bacteria,1MXC7@1224|Proteobacteria,1RS53@1236|Gammaproteobacteria,1X3UH@135614|Xanthomonadales	135614|Xanthomonadales	M	Iron dicitrate transport regulator FecR	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
TLS2_k127_3544136_0	1150626.PHAMO_410003	1.657e-06	51.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
TLS2_k127_3552834_2	66875.JODY01000061_gene10	1.294e-57	215.0	COG0500@1|root,COG2226@2|Bacteria,2GRM0@201174|Actinobacteria	201174|Actinobacteria	Q	o-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
TLS2_k127_3552834_0	234267.Acid_0012	0.0	1648.0	COG0587@1|root,COG0587@2|Bacteria,3Y2TS@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
TLS2_k127_3552834_1	1267535.KB906767_gene1210	5.739e-64	235.0	COG4932@1|root,COG4932@2|Bacteria,3Y3KQ@57723|Acidobacteria,2JMAN@204432|Acidobacteriia	57723|Acidobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_35537_0	1340493.JNIF01000003_gene1305	0.0	1050.0	COG4386@1|root,COG4386@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,CHU_C,DUF5050,PKD,SprB
TLS2_k127_3557312_1	1267535.KB906767_gene4732	1.859e-85	283.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4,IU_nuc_hydro
TLS2_k127_3557312_3	234267.Acid_7793	4.882e-28	113.0	COG1598@1|root,COG1598@2|Bacteria,3Y5U6@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3557312_4	234267.Acid_7792	6.107e-27	113.0	COG1724@1|root,COG1724@2|Bacteria,3Y5Y9@57723|Acidobacteria	57723|Acidobacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
TLS2_k127_3557312_0	861299.J421_0887	2.053e-213	695.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,1ZUNU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Serine/Threonine protein kinases, catalytic domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_3557312_2	1134445.AJJM01000131_gene1253	1.142e-39	156.0	COG0671@1|root,COG0671@2|Bacteria,2I8WW@201174|Actinobacteria	201174|Actinobacteria	I	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS2_k127_3558062_0	1267535.KB906767_gene5368	1.42e-199	631.0	COG0457@1|root,COG0457@2|Bacteria	1267535.KB906767_gene5368|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3558062_1	1267535.KB906767_gene5366	2.302e-93	314.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Dioxygenase_C,TonB_dep_Rec
TLS2_k127_35586_4	661478.OP10G_4092	6.098e-55	196.0	COG0698@1|root,COG0698@2|Bacteria	2|Bacteria	G	galactose-6-phosphate isomerase activity	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2621	LacAB_rpiB
TLS2_k127_35586_3	1192034.CAP_4460	1.258e-67	238.0	2CAZH@1|root,2Z7RU@2|Bacteria,1RBDC@1224|Proteobacteria,42SC7@68525|delta/epsilon subdivisions,2WP8S@28221|Deltaproteobacteria,2Z0M1@29|Myxococcales	28221|Deltaproteobacteria	C	fumarate reductase) cytochrome b subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS2_k127_35586_0	1382359.JIAL01000001_gene2876	0.0	1086.0	COG1053@1|root,COG1053@2|Bacteria,3Y2MQ@57723|Acidobacteria,2JIC4@204432|Acidobacteriia	204432|Acidobacteriia	C	Succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_35586_1	234267.Acid_7403	2.486e-128	413.0	COG0479@1|root,COG0479@2|Bacteria,3Y3XR@57723|Acidobacteria	57723|Acidobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
TLS2_k127_35586_5	1487953.JMKF01000037_gene3215	2.945e-45	171.0	29V4X@1|root,30GII@2|Bacteria,1G573@1117|Cyanobacteria,1HEPV@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_35586_2	234267.Acid_6692	1.002e-103	350.0	COG4191@1|root,COG4191@2|Bacteria,3Y4SZ@57723|Acidobacteria	57723|Acidobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,dCache_3
TLS2_k127_35670_0	1267535.KB906767_gene2802	8.498e-278	861.0	COG0443@1|root,COG0443@2|Bacteria,3Y2XU@57723|Acidobacteria,2JHT1@204432|Acidobacteriia	204432|Acidobacteriia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TLS2_k127_35670_1	1267533.KB906736_gene1391	2.981e-131	430.0	COG0484@1|root,COG0484@2|Bacteria,3Y2XW@57723|Acidobacteria,2JHWV@204432|Acidobacteriia	204432|Acidobacteriia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_35670_2	1267535.KB906767_gene2804	2.404e-46	171.0	COG0789@1|root,COG0789@2|Bacteria,3Y4KX@57723|Acidobacteria,2JJA1@204432|Acidobacteriia	204432|Acidobacteriia	K	MerR HTH family regulatory protein	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
TLS2_k127_35670_3	1236514.BAKL01000014_gene1536	7.307e-12	74.0	COG0407@1|root,COG0407@2|Bacteria,4P05Q@976|Bacteroidetes,2FR9U@200643|Bacteroidia,4ANBY@815|Bacteroidaceae	976|Bacteroidetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TLS2_k127_3582927_4	485913.Krac_1339	3.182e-09	58.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_3582927_0	1288963.ADIS_3099	2.22e-75	262.0	COG1266@1|root,COG1266@2|Bacteria,4NVAP@976|Bacteroidetes,47SVF@768503|Cytophagia	976|Bacteroidetes	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS2_k127_3582927_1	756272.Plabr_1146	5.984e-20	95.0	28MDK@1|root,2ZARD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3582927_3	204669.Acid345_0263	9.722e-11	66.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
TLS2_k127_3587652_1	709797.CSIRO_1146	7.749e-08	61.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2UF5C@28211|Alphaproteobacteria,3JX20@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	FR47-like protein	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
TLS2_k127_3587652_0	67373.JOBF01000012_gene3991	1.659e-46	183.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	ilvG	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1820	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_3588761_1	357808.RoseRS_4254	8.212e-41	160.0	COG3964@1|root,COG3964@2|Bacteria,2G7WR@200795|Chloroflexi	200795|Chloroflexi	S	Amidohydrolase family	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS2_k127_3588761_2	1232453.BAIF02000063_gene1792	3.853e-12	78.0	COG2159@1|root,COG2159@2|Bacteria,1UZI6@1239|Firmicutes,24EHD@186801|Clostridia	186801|Clostridia	G	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_3588761_0	861299.J421_5839	3.294e-83	305.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
TLS2_k127_3593818_0	234267.Acid_1518	1.301e-168	535.0	COG0673@1|root,COG0673@2|Bacteria,3Y74B@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.335	ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_3593818_1	234267.Acid_0902	1.581e-127	413.0	COG0083@1|root,COG0083@2|Bacteria,3Y2ZV@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_3593818_3	1340493.JNIF01000004_gene841	1.871e-58	227.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
TLS2_k127_3593818_2	234267.Acid_5354	3.948e-103	348.0	COG2204@1|root,COG2208@1|root,COG2204@2|Bacteria,COG2208@2|Bacteria,3Y49J@57723|Acidobacteria	57723|Acidobacteria	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
TLS2_k127_3593818_4	1267535.KB906767_gene5203	4.056e-36	139.0	COG1063@1|root,COG1063@2|Bacteria,3Y7C5@57723|Acidobacteria	57723|Acidobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
TLS2_k127_3596433_5	77586.LPERR01G27300.1	3.718e-12	72.0	KOG3002@1|root,KOG3002@2759|Eukaryota	2759|Eukaryota	S	ubiquitin-dependent protein catabolic process	SIAH2	GO:0000003,GO:0000075,GO:0000151,GO:0000209,GO:0000278,GO:0000280,GO:0000902,GO:0000904,GO:0001654,GO:0001745,GO:0001751,GO:0001752,GO:0001754,GO:0002065,GO:0002067,GO:0003674,GO:0003712,GO:0003714,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006915,GO:0006928,GO:0006935,GO:0006996,GO:0007049,GO:0007093,GO:0007127,GO:0007140,GO:0007141,GO:0007154,GO:0007165,GO:0007264,GO:0007275,GO:0007276,GO:0007283,GO:0007346,GO:0007399,GO:0007409,GO:0007411,GO:0007423,GO:0007465,GO:0008022,GO:0008150,GO:0008152,GO:0008219,GO:0008270,GO:0009056,GO:0009057,GO:0009605,GO:0009653,GO:0009791,GO:0009887,GO:0009888,GO:0009889,GO:0009890,GO:0009892,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010466,GO:0010498,GO:0010556,GO:0010558,GO:0010605,GO:0010639,GO:0010646,GO:0010647,GO:0010648,GO:0010821,GO:0010823,GO:0010941,GO:0010942,GO:0010951,GO:0012501,GO:0012505,GO:0016020,GO:0016043,GO:0016567,GO:0016579,GO:0016740,GO:0019005,GO:0019219,GO:0019222,GO:0019538,GO:0019787,GO:0019899,GO:0019904,GO:0019941,GO:0019953,GO:0022008,GO:0022402,GO:0022412,GO:0022414,GO:0022603,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030030,GO:0030111,GO:0030154,GO:0030162,GO:0030163,GO:0030178,GO:0030182,GO:0030855,GO:0030877,GO:0031175,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031396,GO:0031399,GO:0031410,GO:0031461,GO:0031624,GO:0031647,GO:0031648,GO:0031974,GO:0031981,GO:0031982,GO:0032268,GO:0032269,GO:0032386,GO:0032387,GO:0032446,GO:0032501,GO:0032502,GO:0032504,GO:0032879,GO:0032880,GO:0032989,GO:0032990,GO:0032991,GO:0033043,GO:0033157,GO:0035556,GO:0035883,GO:0036211,GO:0036477,GO:0040008,GO:0040011,GO:0040014,GO:0042221,GO:0042330,GO:0042706,GO:0042802,GO:0042803,GO:0042981,GO:0042995,GO:0043005,GO:0043025,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043086,GO:0043154,GO:0043161,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043281,GO:0043412,GO:0043621,GO:0043632,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044297,GO:0044390,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045165,GO:0045466,GO:0045595,GO:0045664,GO:0045676,GO:0045786,GO:0045861,GO:0045930,GO:0045934,GO:0046530,GO:0046532,GO:0046552,GO:0046872,GO:0046914,GO:0046983,GO:0048232,GO:0048285,GO:0048468,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048592,GO:0048609,GO:0048638,GO:0048663,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048749,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050767,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051223,GO:0051224,GO:0051239,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051321,GO:0051336,GO:0051346,GO:0051402,GO:0051603,GO:0051704,GO:0051716,GO:0051726,GO:0051960,GO:0052547,GO:0052548,GO:0060255,GO:0060284,GO:0060341,GO:0060429,GO:0060548,GO:0060828,GO:0061564,GO:0061630,GO:0061659,GO:0061982,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070201,GO:0070646,GO:0070647,GO:0070997,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090087,GO:0090090,GO:0090317,GO:0090596,GO:0097458,GO:0097485,GO:0097708,GO:0097718,GO:0120025,GO:0120036,GO:0120039,GO:0140013,GO:0140096,GO:0140110,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1902531,GO:1902533,GO:1902679,GO:1903046,GO:1903047,GO:1903214,GO:1903215,GO:1903320,GO:1903506,GO:1903507,GO:1903533,GO:1903747,GO:1903748,GO:1903827,GO:1903828,GO:1904950,GO:1990234,GO:2000026,GO:2000027,GO:2000116,GO:2000117,GO:2001141,GO:2001233,GO:2001234,GO:2001235,GO:2001236,GO:2001237,GO:2001242,GO:2001244	2.3.2.27	ko:K04506,ko:K08742,ko:K22256	ko04013,ko04115,ko04120,ko04310,map04013,map04115,map04120,map04310	-	-	-	ko00000,ko00001,ko01000,ko04121,ko04131	-	-	-	Sina
TLS2_k127_3596433_0	1267535.KB906767_gene4131	1.101e-233	733.0	COG2303@1|root,COG2303@2|Bacteria,3Y41Y@57723|Acidobacteria,2JIXF@204432|Acidobacteriia	57723|Acidobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_3596433_1	1267535.KB906767_gene1506	4.414e-96	320.0	COG0689@1|root,COG0689@2|Bacteria,3Y2FP@57723|Acidobacteria,2JHM3@204432|Acidobacteriia	204432|Acidobacteriia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
TLS2_k127_3596433_3	1267535.KB906767_gene1507	3.884e-59	212.0	COG0127@1|root,COG0127@2|Bacteria,3Y7Z7@57723|Acidobacteria	57723|Acidobacteria	F	Ham1 family	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
TLS2_k127_3596433_2	861299.J421_2105	2.557e-88	312.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1ZSUS@142182|Gemmatimonadetes	2|Bacteria	MU	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,2.C.1.2	-	-	BSP,Bac_surface_Ag,PD40,Peptidase_MA_2
TLS2_k127_3607918_3	234267.Acid_4235	5.205e-36	147.0	28K54@1|root,2Z9TW@2|Bacteria,3Y3Z7@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3607918_2	1267535.KB906767_gene3998	2.03e-39	151.0	2EFR0@1|root,339H2@2|Bacteria,3Y5M9@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3607918_4	1340493.JNIF01000003_gene4700	3.391e-33	137.0	COG3088@1|root,COG3088@2|Bacteria	2|Bacteria	O	cytochrome complex assembly	ccmH	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098567,GO:1901564	-	ko:K02198,ko:K02200,ko:K04016,ko:K04017,ko:K04018	-	-	R05712	RC00176	ko00000,ko02000	9.B.14.1	-	-	CcmH
TLS2_k127_3607918_0	1340493.JNIF01000003_gene4699	2.911e-286	893.0	COG1138@1|root,COG1138@2|Bacteria,3Y40N@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Cytochrome c assembly protein	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
TLS2_k127_3607918_1	234267.Acid_4231	1.745e-45	168.0	COG2332@1|root,COG2332@2|Bacteria,3Y57C@57723|Acidobacteria	57723|Acidobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
TLS2_k127_3607918_5	234267.Acid_1432	6.945e-12	70.0	COG0500@1|root,COG2226@2|Bacteria,3Y7N3@57723|Acidobacteria	57723|Acidobacteria	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	MetW
TLS2_k127_3619848_1	1267533.KB906735_gene4664	5.078e-33	129.0	COG1695@1|root,COG1695@2|Bacteria,3Y5FA@57723|Acidobacteria,2JN37@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_3619848_0	234267.Acid_4578	5.602e-206	670.0	COG0577@1|root,COG0577@2|Bacteria,3Y36E@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_3625728_4	658187.LDG_7441	3.316e-14	75.0	COG0582@1|root,COG0582@2|Bacteria,1NX90@1224|Proteobacteria,1SDT1@1236|Gammaproteobacteria,1JE8H@118969|Legionellales	118969|Legionellales	L	Phage integrase family	xerD	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_3625728_1	1454004.AW11_01877	1.681e-147	478.0	COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2VICA@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_3625728_2	1454004.AW11_01876	5.282e-142	456.0	COG0582@1|root,COG0582@2|Bacteria,1NX90@1224|Proteobacteria,2VJRU@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_3625728_0	1454004.AW11_01875	2.063e-154	498.0	COG4974@1|root,COG4974@2|Bacteria,1QUHS@1224|Proteobacteria,2VM8C@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_3625728_3	234267.Acid_6800	1.305e-34	138.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_3635305_3	882082.SaccyDRAFT_3320	5.186e-12	75.0	COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria,4E1BE@85010|Pseudonocardiales	201174|Actinobacteria	P	PFAM Sodium sulfate symporter transmembrane region	sdcS	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
TLS2_k127_3635305_2	304371.MCP_1339	2.61e-12	68.0	COG3316@1|root,arCOG02134@2157|Archaea	2157|Archaea	L	COG3316 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1,HTH_Tnp_1
TLS2_k127_3635305_0	991905.SL003B_0706	1.095e-174	554.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2TTG7@28211|Alphaproteobacteria,4BT5R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve,rve_3
TLS2_k127_3635305_1	391625.PPSIR1_16130	1.425e-28	117.0	COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,42Y58@68525|delta/epsilon subdivisions,2WTVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
TLS2_k127_3650834_1	234267.Acid_5892	3.519e-94	313.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	B12-binding,Radical_SAM
TLS2_k127_3650834_2	446470.Snas_3333	8.215e-43	171.0	2DBK2@1|root,2Z9Q1@2|Bacteria,2H40U@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3650834_4	338969.Rfer_0436	3.841e-32	134.0	COG0796@1|root,COG0796@2|Bacteria,1QZ6H@1224|Proteobacteria	1224|Proteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3650834_3	871963.Desdi_0792	2.124e-41	165.0	COG1082@1|root,COG1082@2|Bacteria,1TRXP@1239|Firmicutes,24EWV@186801|Clostridia,262DG@186807|Peptococcaceae	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	ko:K22233	ko00562,map00562	-	R11772	-	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_3650834_0	555079.Toce_0510	8.29e-169	536.0	COG1089@1|root,COG1089@2|Bacteria,1TQ9T@1239|Firmicutes,24863@186801|Clostridia,42HYB@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_3650834_5	287.DR97_5104	0.0001018	47.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1YHXR@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
TLS2_k127_3664144_0	1255043.TVNIR_0913	2.022e-72	260.0	COG4974@1|root,COG4974@2|Bacteria,1QUHS@1224|Proteobacteria,1S2C4@1236|Gammaproteobacteria,1X0IU@135613|Chromatiales	135613|Chromatiales	L	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_3664144_1	1117958.PE143B_0100130	5.936e-10	68.0	COG0582@1|root,COG0582@2|Bacteria,1NX90@1224|Proteobacteria,1SDT1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_3666517_1	388051.AUFE01000059_gene6131	8.948e-37	145.0	COG1215@1|root,COG1215@2|Bacteria,1MW1E@1224|Proteobacteria,2VJ3J@28216|Betaproteobacteria,1K2K0@119060|Burkholderiaceae	28216|Betaproteobacteria	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS2_k127_3666517_0	935863.AWZR01000001_gene1762	7.752e-55	208.0	29M6H@1|root,3083Y@2|Bacteria,1RJTC@1224|Proteobacteria,1T7NK@1236|Gammaproteobacteria,1X9GZ@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3666517_2	1038860.AXAP01000044_gene7650	1.345e-15	91.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,3JR2T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI,TAL_FSA
TLS2_k127_366945_4	1267535.KB906767_gene4269	1.421e-18	87.0	COG2834@1|root,COG2834@2|Bacteria,3Y51N@57723|Acidobacteria	57723|Acidobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	LolA,LolA_like
TLS2_k127_366945_1	1267535.KB906767_gene4268	3.415e-121	402.0	COG3503@1|root,COG3503@2|Bacteria,3Y73K@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
TLS2_k127_366945_2	1340493.JNIF01000003_gene1770	1.545e-120	389.0	COG0745@1|root,COG0745@2|Bacteria,3Y522@57723|Acidobacteria	57723|Acidobacteria	K	PFAM response regulator receiver	-	-	-	ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_366945_0	234267.Acid_2165	1.726e-130	435.0	COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,3Y6RV@57723|Acidobacteria	57723|Acidobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_366945_3	179408.Osc7112_0281	5.937e-19	94.0	COG1503@1|root,COG1503@2|Bacteria,1G29A@1117|Cyanobacteria,1H8W3@1150|Oscillatoriales	1117|Cyanobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3670769_0	1267535.KB906767_gene5357	6.064e-158	506.0	COG0031@1|root,COG0031@2|Bacteria,3Y45Z@57723|Acidobacteria,2JHUN@204432|Acidobacteriia	204432|Acidobacteriia	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_3670769_5	234267.Acid_5883	2.477e-55	197.0	COG1959@1|root,COG1959@2|Bacteria,3Y87Y@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TLS2_k127_3670769_7	1163409.UUA_10866	1.252e-51	191.0	COG1376@1|root,COG1376@2|Bacteria,1RA7Q@1224|Proteobacteria,1S5JW@1236|Gammaproteobacteria,1XC1Y@135614|Xanthomonadales	135614|Xanthomonadales	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD_2
TLS2_k127_3670769_4	234267.Acid_4899	1.957e-68	240.0	COG1376@1|root,COG1376@2|Bacteria,3Y5WR@57723|Acidobacteria	57723|Acidobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS2_k127_3670769_3	386456.JQKN01000002_gene2491	1.641e-98	332.0	COG2133@1|root,arCOG02796@2157|Archaea,2XV9N@28890|Euryarchaeota	28890|Euryarchaeota	G	glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS2_k127_3670769_6	1396418.BATQ01000101_gene5440	4.94e-55	214.0	COG1524@1|root,COG1524@2|Bacteria,46TNY@74201|Verrucomicrobia,2IV18@203494|Verrucomicrobiae	203494|Verrucomicrobiae	U	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_3670769_1	861299.J421_4089	3.399e-152	491.0	COG1680@1|root,COG1680@2|Bacteria,1ZUDD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_3670769_2	1267535.KB906767_gene3579	1.382e-120	396.0	COG1312@1|root,COG1312@2|Bacteria,3Y6WX@57723|Acidobacteria	57723|Acidobacteria	G	D-mannonate dehydratase (UxuA)	-	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
TLS2_k127_3671710_2	1115632.JAFW01000001_gene1471	5.927e-32	130.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,1WBMC@1268|Micrococcaceae	201174|Actinobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_3671710_0	234267.Acid_5289	9.64e-104	342.0	COG0800@1|root,COG0800@2|Bacteria,3Y4HZ@57723|Acidobacteria	57723|Acidobacteria	G	2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
TLS2_k127_3671710_1	234267.Acid_0458	2.236e-54	198.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_3671710_4	324602.Caur_3898	1.175e-06	55.0	COG5662@1|root,COG5662@2|Bacteria,2GA8Q@200795|Chloroflexi,377SA@32061|Chloroflexia	32061|Chloroflexia	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_3671710_3	1449049.JONW01000008_gene759	1.961e-23	103.0	COG1735@1|root,COG1735@2|Bacteria,1NPYS@1224|Proteobacteria,2U1F9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
TLS2_k127_3681809_2	118168.MC7420_4332	3.159e-198	636.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H9T8@1150|Oscillatoriales	1117|Cyanobacteria	Q	Amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
TLS2_k127_3681809_0	272123.Anacy_5459	0.0	1937.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
TLS2_k127_3681809_1	1144275.COCOR_05741	1.358e-215	696.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,42M9A@68525|delta/epsilon subdivisions,2WJ3Y@28221|Deltaproteobacteria,2YZU4@29|Myxococcales	28221|Deltaproteobacteria	S	Penicillin amidase	-	-	3.5.1.11,3.5.1.97	ko:K01434,ko:K07116	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS2_k127_3684655_1	162425.CADANIAP00002785	8.567e-14	83.0	COG0457@1|root,KOG1840@2759|Eukaryota,38CFM@33154|Opisthokonta,3NYQ3@4751|Fungi,3QJXH@4890|Ascomycota,20AHZ@147545|Eurotiomycetes	4751|Fungi	Z	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,PNP_UDP_1,TPR_10
TLS2_k127_3684655_0	1500257.JQNM01000001_gene3364	3.469e-113	383.0	COG0520@1|root,COG0520@2|Bacteria,1MXH1@1224|Proteobacteria,2TQUT@28211|Alphaproteobacteria,4BD1H@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_3693655_0	1123256.KB907945_gene379	1.002e-156	502.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria,1X74R@135614|Xanthomonadales	135614|Xanthomonadales	L	Transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_3695978_0	1340493.JNIF01000003_gene4471	7.527e-152	494.0	COG2304@1|root,COG2304@2|Bacteria,3Y5S3@57723|Acidobacteria	57723|Acidobacteria	S	Vault protein inter-alpha-trypsin domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
TLS2_k127_3695978_1	330214.NIDE1182	0.0004594	51.0	2E7Z1@1|root,332DD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3708398_1	234267.Acid_2874	7.721e-97	323.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
TLS2_k127_3708398_0	234267.Acid_3929	1.784e-207	662.0	COG0405@1|root,COG0405@2|Bacteria,3Y2I7@57723|Acidobacteria	57723|Acidobacteria	M	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_3708398_2	1232410.KI421418_gene2425	4.711e-54	200.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,42RV4@68525|delta/epsilon subdivisions,2WP4W@28221|Deltaproteobacteria,43SSQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS2_k127_3708398_3	1123276.KB893245_gene1781	5.895e-24	104.0	COG3119@1|root,COG3119@2|Bacteria,4NEM3@976|Bacteroidetes,47M3C@768503|Cytophagia	976|Bacteroidetes	P	PFAM sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_3710428_1	234267.Acid_5013	4.289e-159	511.0	COG2192@1|root,COG2192@2|Bacteria,3Y6AX@57723|Acidobacteria	57723|Acidobacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TLS2_k127_3710428_0	234267.Acid_5012	3.065e-299	930.0	COG0008@1|root,COG0008@2|Bacteria,3Y7DS@57723|Acidobacteria	57723|Acidobacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	-	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
TLS2_k127_3710428_2	234267.Acid_5011	1.028e-51	187.0	COG0008@1|root,COG0008@2|Bacteria,3Y465@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS2_k127_371248_0	1123278.KB893615_gene5179	1.302e-116	392.0	COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,4NNEF@976|Bacteroidetes,47PBP@768503|Cytophagia	976|Bacteroidetes	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
TLS2_k127_371248_1	234267.Acid_7237	1.03e-78	272.0	COG5551@1|root,COG5551@2|Bacteria,3Y7HB@57723|Acidobacteria	57723|Acidobacteria	S	Pfam:DUF2276	-	-	-	-	-	-	-	-	-	-	-	-	CRISPR_Cas6
TLS2_k127_371248_2	234267.Acid_7668	8.731e-66	229.0	COG3605@1|root,COG3605@2|Bacteria,3Y7TF@57723|Acidobacteria	57723|Acidobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2
TLS2_k127_371248_3	1340493.JNIF01000004_gene836	4.065e-27	117.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
TLS2_k127_3716850_0	1267535.KB906767_gene247	9.944e-144	462.0	COG1820@1|root,COG1820@2|Bacteria,3Y3NQ@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS2_k127_3716850_2	234267.Acid_1158	2.855e-53	198.0	2E71G@1|root,331K5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3716850_1	234267.Acid_5385	1.849e-110	367.0	COG1063@1|root,COG1063@2|Bacteria,3Y6GC@57723|Acidobacteria	57723|Acidobacteria	E	Glucose dehydrogenase C-terminus	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_3720296_0	1216976.AX27061_1834	5.791e-51	194.0	COG2199@1|root,COG2199@2|Bacteria,1R3R8@1224|Proteobacteria,2VJND@28216|Betaproteobacteria,3T58B@506|Alcaligenaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,dCache_1
TLS2_k127_3735553_1	880073.Calab_0673	1.298e-38	162.0	COG1262@1|root,COG1262@2|Bacteria,2NR84@2323|unclassified Bacteria	2|Bacteria	S	Sulfatase-modifying factor enzyme 1	gldK	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TLS2_k127_3735553_0	1267535.KB906767_gene605	5.014e-223	696.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,3Y2I9@57723|Acidobacteria,2JHNT@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TLS2_k127_374098_1	1403819.BATR01000135_gene4814	9.498e-39	156.0	COG4409@1|root,COG4409@2|Bacteria,46WX2@74201|Verrucomicrobia	74201|Verrucomicrobia	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_374098_0	240016.ABIZ01000001_gene764	4.982e-144	476.0	COG3119@1|root,COG3119@2|Bacteria,46ZJS@74201|Verrucomicrobia,2IVBK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_374098_2	1038867.AXAY01000001_gene6449	4.5e-18	96.0	COG4409@1|root,COG4692@1|root,COG4409@2|Bacteria,COG4692@2|Bacteria,1Q1EG@1224|Proteobacteria,2TUY5@28211|Alphaproteobacteria,3JTIJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_3742735_3	234267.Acid_6502	1.298e-29	119.0	COG0149@1|root,COG0149@2|Bacteria,3Y2YS@57723|Acidobacteria	57723|Acidobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TLS2_k127_3742735_0	234267.Acid_5322	8.598e-138	445.0	COG3802@1|root,COG3802@2|Bacteria,3Y6GZ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3742735_2	330214.NIDE1902	2.525e-63	227.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_3742735_1	639030.JHVA01000001_gene1889	2.815e-110	366.0	COG1629@1|root,COG4771@2|Bacteria,3Y9D4@57723|Acidobacteria,2JP0W@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_3746804_4	1340493.JNIF01000004_gene521	2.821e-21	97.0	COG0624@1|root,COG0624@2|Bacteria,3Y2XS@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Peptidase M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_3746804_3	208439.AJAP_35865	2.1e-29	123.0	COG2913@1|root,COG2913@2|Bacteria,2INAT@201174|Actinobacteria,4EC7I@85010|Pseudonocardiales	201174|Actinobacteria	J	Protein of unknown function (DUF3574)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3574
TLS2_k127_3746804_1	234267.Acid_0687	2.545e-38	162.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y6TZ@57723|Acidobacteria	2|Bacteria	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2
TLS2_k127_3746804_0	251221.35212555	2.61e-205	664.0	COG2366@1|root,COG2366@2|Bacteria,1G4M5@1117|Cyanobacteria	1117|Cyanobacteria	S	penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS2_k127_3746804_2	448385.sce5416	1.942e-35	140.0	COG1858@1|root,COG1858@2|Bacteria,1QTHX@1224|Proteobacteria,43F3A@68525|delta/epsilon subdivisions,2WZD5@28221|Deltaproteobacteria,2YUR6@29|Myxococcales	28221|Deltaproteobacteria	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG
TLS2_k127_3753735_2	234267.Acid_6961	1.308e-90	299.0	COG5016@1|root,COG5016@2|Bacteria,3Y6G9@57723|Acidobacteria	57723|Acidobacteria	C	Conserved carboxylase domain	-	-	2.1.3.1	ko:K03416	ko00640,map00640	-	R00353,R00930	RC00040,RC00097	ko00000,ko00001,ko01000	-	-	-	HMGL-like,PYC_OADA
TLS2_k127_3753735_1	1340493.JNIF01000003_gene2622	3.227e-114	377.0	COG1105@1|root,COG1105@2|Bacteria,3Y5F9@57723|Acidobacteria	57723|Acidobacteria	G	Phosphomethylpyrimidine kinase	-	-	2.7.1.56	ko:K00882	ko00051,map00051	-	R02071	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS2_k127_3753735_3	861299.J421_3788	4.391e-60	223.0	COG5637@1|root,COG5637@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892,Polyketide_cyc
TLS2_k127_3753735_5	1340493.JNIF01000003_gene2546	1.025e-33	142.0	2EZNS@1|root,33STS@2|Bacteria,3Y75C@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3753735_0	1340493.JNIF01000003_gene2092	7.974e-261	814.0	COG2303@1|root,COG2303@2|Bacteria,3Y41Y@57723|Acidobacteria	2|Bacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N
TLS2_k127_3763300_4	485913.Krac_11430	2.05e-99	349.0	COG2936@1|root,COG2936@2|Bacteria,2G85Q@200795|Chloroflexi	2|Bacteria	S	PFAM X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
TLS2_k127_3763300_6	234267.Acid_6598	1.628e-74	262.0	COG4242@1|root,COG4242@2|Bacteria,3Y6RX@57723|Acidobacteria	57723|Acidobacteria	M	Peptidase family S51	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
TLS2_k127_3763300_5	215803.DB30_4904	6.642e-89	308.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,42TQ5@68525|delta/epsilon subdivisions,2WQ0T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_3763300_1	247634.GPB2148_1837	4.937e-123	424.0	COG4773@1|root,COG4773@2|Bacteria,1NRKQ@1224|Proteobacteria,1SJXP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
TLS2_k127_3763300_3	1121374.KB891575_gene801	1.81e-107	356.0	2CEWZ@1|root,33QME@2|Bacteria,1NTHN@1224|Proteobacteria,1SKH8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3763300_0	1121374.KB891575_gene800	2.207e-176	575.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16,TPR_8
TLS2_k127_3763300_7	472759.Nhal_0303	9.281e-69	236.0	COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,1S1HV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_3763300_8	266779.Meso_0348	4.123e-23	100.0	2E3HM@1|root,32YG7@2|Bacteria,1NM0U@1224|Proteobacteria,2TZYE@28211|Alphaproteobacteria,43RX1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3763300_2	319224.Sputcn32_2047	1.031e-122	404.0	COG3507@1|root,COG3507@2|Bacteria,1R4H2@1224|Proteobacteria,1RSCC@1236|Gammaproteobacteria,2QAFW@267890|Shewanellaceae	1236|Gammaproteobacteria	G	C-terminal of Glycosyl hydrolases family 43	-	-	3.2.1.99	ko:K06113	-	-	-	-	ko00000,ko01000	-	GH43	-	GH43_C,Glyco_hydro_43,Laminin_G_3
TLS2_k127_3764778_2	1267535.KB906767_gene4913	7.209e-96	319.0	COG1028@1|root,COG1028@2|Bacteria,3Y3YM@57723|Acidobacteria	57723|Acidobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_3764778_0	234267.Acid_3945	1.335e-259	805.0	COG0043@1|root,COG0043@2|Bacteria,3Y3BY@57723|Acidobacteria	57723|Acidobacteria	H	Belongs to the UbiD family	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
TLS2_k127_3764778_1	234267.Acid_2559	2.798e-108	366.0	COG0786@1|root,COG0786@2|Bacteria	2|Bacteria	P	glutamate:sodium symporter activity	gltS	GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005342,GO:0005343,GO:0005416,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006835,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015081,GO:0015171,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015501,GO:0015672,GO:0015711,GO:0015849,GO:0016020,GO:0017153,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	iIT341.HP1506,iPC815.YPO0035,iZ_1308.Z5081	Glt_symporter
TLS2_k127_3764778_5	1340493.JNIF01000003_gene1921	3.291e-47	179.0	COG2885@1|root,COG2885@2|Bacteria,3Y425@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS2_k127_3764778_4	234267.Acid_5885	8.214e-55	202.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR,Sortilin-Vps10
TLS2_k127_3764778_3	997884.HMPREF1068_01646	1.345e-63	227.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	AXE1,Abhydrolase_7,DLH,Hydrolase_4,LTD,Peptidase_S9
TLS2_k127_3776004_2	1340493.JNIF01000003_gene4059	3.471e-18	87.0	2C730@1|root,33CNG@2|Bacteria,3Y5XE@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3776004_0	1396418.BATQ01000138_gene3923	5.337e-184	586.0	COG2960@1|root,COG2960@2|Bacteria	2|Bacteria	M	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
TLS2_k127_3776004_1	1396418.BATQ01000138_gene3922	1.436e-77	261.0	COG2010@1|root,COG2010@2|Bacteria,46UH6@74201|Verrucomicrobia,2IWNW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Protein of unknown function (DUF1587)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5
TLS2_k127_3779930_2	1128421.JAGA01000002_gene335	4.539e-69	238.0	COG2124@1|root,COG2124@2|Bacteria	2|Bacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_3779930_0	234267.Acid_5511	5.961e-87	290.0	COG2065@1|root,COG2065@2|Bacteria,3Y2S1@57723|Acidobacteria	57723|Acidobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
TLS2_k127_3779930_1	1267535.KB906767_gene4452	2.325e-79	282.0	COG4251@1|root,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Protoglobin,Response_reg
TLS2_k127_3779930_3	742727.HMPREF9447_01588	2.294e-05	51.0	COG3401@1|root,COG3401@2|Bacteria,4NFM5@976|Bacteroidetes,2FPSM@200643|Bacteroidia,4ANKU@815|Bacteroidaceae	976|Bacteroidetes	S	candidate rhamnogalacturonan lyase, polysaccharide lyase family 11 protein K01238	-	-	4.2.2.23	ko:K18197	-	-	-	-	ko00000,ko01000	-	PL11	-	-
TLS2_k127_3780161_1	234267.Acid_5763	6.122e-57	201.0	COG0247@1|root,COG0247@2|Bacteria,3Y4IR@57723|Acidobacteria	57723|Acidobacteria	C	Cysteine-rich domain	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
TLS2_k127_3780161_0	234267.Acid_5762	2.682e-212	668.0	COG1139@1|root,COG1139@2|Bacteria,3Y3R8@57723|Acidobacteria	57723|Acidobacteria	C	cluster binding protein	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
TLS2_k127_3780161_2	234267.Acid_5761	1.68e-05	55.0	COG1556@1|root,COG1556@2|Bacteria,3Y5T6@57723|Acidobacteria	57723|Acidobacteria	S	Pfam:DUF162	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
TLS2_k127_3783551_0	1340493.JNIF01000003_gene4197	1.544e-194	614.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_3783551_1	1340493.JNIF01000003_gene4196	6.989e-30	121.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_3783778_0	1340493.JNIF01000003_gene1385	0.0	1303.0	COG1629@1|root,COG4771@2|Bacteria,3Y2GB@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_3783778_1	204669.Acid345_0328	2.718e-196	626.0	COG3534@1|root,COG3534@2|Bacteria,3Y48A@57723|Acidobacteria,2JKQ1@204432|Acidobacteriia	204432|Acidobacteriia	G	Alpha-L-arabinofuranosidase C-terminus	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
TLS2_k127_3783778_5	449673.BACSTE_02129	0.0005553	49.0	COG5652@1|root,COG5652@2|Bacteria,4NIE7@976|Bacteroidetes,2FQJV@200643|Bacteroidia,4AQA0@815|Bacteroidaceae	976|Bacteroidetes	S	Domain of unknown function (DUF4962)	-	GO:0003674,GO:0003824,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006082,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008201,GO:0009056,GO:0009057,GO:0009987,GO:0016829,GO:0016835,GO:0016837,GO:0030202,GO:0030203,GO:0030211,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044464,GO:0047488,GO:0071704,GO:0097367,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1901681,GO:1903510	4.2.2.7,4.2.2.8	ko:K19051	-	-	-	-	ko00000,ko01000	-	PL21	-	DUF4962,Hepar_II_III
TLS2_k127_3783778_2	1267535.KB906767_gene918	6.139e-196	625.0	COG0205@1|root,COG0205@2|Bacteria,3Y4A9@57723|Acidobacteria,2JKQ8@204432|Acidobacteriia	204432|Acidobacteriia	G	Phosphofructokinase	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
TLS2_k127_3783778_3	1340493.JNIF01000003_gene2135	6.689e-89	297.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_3783778_4	234267.Acid_5618	7.811e-60	211.0	COG1915@1|root,COG1915@2|Bacteria,3Y6MM@57723|Acidobacteria	57723|Acidobacteria	S	LOR/SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
TLS2_k127_3784122_0	234267.Acid_5456	0.0	1358.0	COG0086@1|root,COG0086@2|Bacteria,3Y2FZ@57723|Acidobacteria	57723|Acidobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
TLS2_k127_3784122_1	1267535.KB906767_gene4216	2.203e-98	325.0	COG2860@1|root,COG2860@2|Bacteria,3Y4PD@57723|Acidobacteria	57723|Acidobacteria	S	UPF0126 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
TLS2_k127_3784122_2	1340493.JNIF01000003_gene2716	1.094e-80	276.0	COG5621@1|root,COG5621@2|Bacteria	2|Bacteria	S	spheroidene biosynthetic process	attH	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
TLS2_k127_3791503_4	234267.Acid_7696	6.588e-113	373.0	COG1166@1|root,COG1166@2|Bacteria,3Y449@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
TLS2_k127_3791503_2	1379270.AUXF01000002_gene1241	3.854e-128	446.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZTK4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
TLS2_k127_3791503_7	251221.35211653	6.15e-36	142.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
TLS2_k127_3791503_5	639030.JHVA01000001_gene3050	3.465e-87	301.0	COG1879@1|root,COG1879@2|Bacteria,3Y3RJ@57723|Acidobacteria,2JK89@204432|Acidobacteriia	2|Bacteria	K	IclR helix-turn-helix domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	HTH_IclR,LacI,Peripla_BP_4
TLS2_k127_3791503_6	204669.Acid345_0640	2.066e-66	238.0	COG0657@1|root,COG0657@2|Bacteria,3Y44Z@57723|Acidobacteria,2JJYN@204432|Acidobacteriia	204432|Acidobacteriia	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS2_k127_3791503_0	1340493.JNIF01000004_gene88	1.161e-291	932.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_3791503_3	639030.JHVA01000001_gene3704	3.361e-120	398.0	COG2271@1|root,COG2271@2|Bacteria,3Y2VG@57723|Acidobacteria,2JIWZ@204432|Acidobacteriia	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
TLS2_k127_3791503_1	926556.Echvi_0405	1.472e-162	535.0	COG2407@1|root,COG2407@2|Bacteria,4NF0C@976|Bacteroidetes,47JET@768503|Cytophagia	976|Bacteroidetes	G	Catalyzes the conversion of L-arabinose to L-ribulose	-	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Isome,Fucose_iso_C
TLS2_k127_3795149_9	1340493.JNIF01000003_gene3421	4.111e-14	75.0	COG1629@1|root,COG1629@2|Bacteria,3Y67H@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_3795149_3	28072.Nos7524_2019	2.943e-67	238.0	2DBB1@1|root,2Z854@2|Bacteria,1G05N@1117|Cyanobacteria	1117|Cyanobacteria	S	Domain of Unknown Function (DUF1206)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1206
TLS2_k127_3795149_2	234267.Acid_1226	7.091e-69	238.0	COG0351@1|root,COG0351@2|Bacteria,3Y4DB@57723|Acidobacteria	57723|Acidobacteria	H	TIGRFAM Phosphomethylpyrimidine kinase	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
TLS2_k127_3795149_7	1340493.JNIF01000003_gene1667	1.589e-18	94.0	COG0351@1|root,COG0351@2|Bacteria,3Y4DB@57723|Acidobacteria	57723|Acidobacteria	H	TIGRFAM Phosphomethylpyrimidine kinase	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
TLS2_k127_3795149_4	234267.Acid_1313	1.58e-60	226.0	COG1361@1|root,COG1361@2|Bacteria,3Y8BF@57723|Acidobacteria	57723|Acidobacteria	M	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3795149_5	234267.Acid_1312	4.821e-37	148.0	292F3@1|root,2ZPZC@2|Bacteria,3Y90G@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3795149_1	234267.Acid_1311	2.585e-73	254.0	COG0631@1|root,COG0631@2|Bacteria,3Y7SC@57723|Acidobacteria	57723|Acidobacteria	T	Protein phosphatase 2C	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
TLS2_k127_3795149_0	234267.Acid_1295	2.105e-109	370.0	COG0457@1|root,COG0457@2|Bacteria,3Y2VC@57723|Acidobacteria	57723|Acidobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
TLS2_k127_3795149_6	1340493.JNIF01000003_gene3028	5.323e-32	128.0	28VY2@1|root,2ZHZA@2|Bacteria,3Y90R@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3795149_8	1267535.KB906767_gene830	3.571e-16	81.0	COG0324@1|root,COG0324@2|Bacteria,3Y3CE@57723|Acidobacteria,2JICH@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
TLS2_k127_3806248_0	1267535.KB906767_gene766	3.127e-150	496.0	COG0551@1|root,COG0551@2|Bacteria,3Y7FR@57723|Acidobacteria	57723|Acidobacteria	L	Protein of unknown function (DUF1595)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt3,PSD2,PSD3,PSD4,PSD5
TLS2_k127_3806248_1	886293.Sinac_5961	2.743e-22	99.0	COG2960@1|root,COG2960@2|Bacteria,2IX87@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
TLS2_k127_3814218_0	1340493.JNIF01000003_gene2575	1.032e-89	307.0	COG1629@1|root,COG1629@2|Bacteria,3Y3KT@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_3814218_1	1403819.BATR01000135_gene4814	4.821e-79	277.0	COG4409@1|root,COG4409@2|Bacteria,46WX2@74201|Verrucomicrobia	74201|Verrucomicrobia	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_3818589_3	1340493.JNIF01000003_gene2613	0.0003379	51.0	COG4585@1|root,COG4585@2|Bacteria,3Y59R@57723|Acidobacteria	57723|Acidobacteria	T	PFAM ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_3818589_1	1340493.JNIF01000003_gene2582	9.206e-105	353.0	COG0666@1|root,COG0666@2|Bacteria,3Y6UE@57723|Acidobacteria	57723|Acidobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2
TLS2_k127_3818589_0	234267.Acid_6743	3.253e-115	375.0	COG1137@1|root,COG1137@2|Bacteria,3Y2MC@57723|Acidobacteria	57723|Acidobacteria	S	PFAM ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_3818589_2	1267535.KB906767_gene2729	2.313e-64	229.0	COG1452@1|root,COG1934@1|root,COG1452@2|Bacteria,COG1934@2|Bacteria,3Y388@57723|Acidobacteria	57723|Acidobacteria	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC,OstA
TLS2_k127_3819832_9	68219.JNXI01000002_gene4203	2.117e-26	114.0	COG2207@1|root,COG2207@2|Bacteria,2GM8I@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS2_k127_3819832_6	502025.Hoch_2580	6.13e-56	199.0	COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,434KP@68525|delta/epsilon subdivisions,2WYXY@28221|Deltaproteobacteria,2Z0W7@29|Myxococcales	28221|Deltaproteobacteria	C	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_3819832_8	1158756.AQXQ01000012_gene1710	5.186e-35	144.0	2DYCI@1|root,32V58@2|Bacteria,1N69T@1224|Proteobacteria,1SBJX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2459
TLS2_k127_3819832_7	187272.Mlg_1365	7.115e-49	181.0	2C8PG@1|root,32RMK@2|Bacteria,1N0UQ@1224|Proteobacteria,1SBBP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3819832_10	1449353.JQMQ01000005_gene176	2.682e-06	61.0	COG0815@1|root,COG0815@2|Bacteria,2GP5I@201174|Actinobacteria,2NEQZ@228398|Streptacidiphilus	201174|Actinobacteria	M	Carbon-nitrogen hydrolase	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
TLS2_k127_3819832_2	1459636.NTE_01150	3.344e-120	395.0	COG0346@1|root,arCOG03101@2157|Archaea	2157|Archaea	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_3819832_5	251229.Chro_1450	4.065e-69	242.0	COG0346@1|root,COG0400@1|root,COG0346@2|Bacteria,COG0400@2|Bacteria	2|Bacteria	S	palmitoyl-(protein) hydrolase activity	-	-	-	ko:K06999,ko:K15975	-	-	-	-	ko00000	-	-	-	Abhydrolase_2,Glyoxalase
TLS2_k127_3819832_4	994479.GL877878_gene1200	3.16e-77	269.0	COG1028@1|root,COG1028@2|Bacteria,2GWHQ@201174|Actinobacteria,4E2S7@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
TLS2_k127_3819832_3	234267.Acid_1666	1.552e-99	341.0	COG1538@1|root,COG1538@2|Bacteria,3Y4MP@57723|Acidobacteria	57723|Acidobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS2_k127_3819832_0	1267535.KB906767_gene5438	6.254e-150	492.0	COG0154@1|root,COG0154@2|Bacteria,3Y41H@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS2_k127_3819832_1	234267.Acid_1405	2.665e-131	434.0	COG0303@1|root,COG0303@2|Bacteria,3Y3F0@57723|Acidobacteria	57723|Acidobacteria	H	TIGRFAM molybdenum cofactor synthesis	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS2_k127_3821756_1	118168.MC7420_784	8.476e-52	197.0	COG3772@1|root,COG3772@2|Bacteria,1GCAA@1117|Cyanobacteria	1117|Cyanobacteria	S	lysozyme	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3821756_0	1120934.KB894403_gene295	6.262e-58	233.0	COG1672@1|root,COG1672@2|Bacteria,2IEQ3@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Archaeal ATPase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3821756_2	35754.JNYJ01000010_gene1691	1.506e-37	162.0	COG4995@1|root,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
TLS2_k127_3821756_3	710111.FraQA3DRAFT_3337	6.326e-36	154.0	2F1HK@1|root,33UI3@2|Bacteria,2IKGA@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3830535_1	265072.Mfla_0844	4.406e-46	176.0	2BQC7@1|root,32J7B@2|Bacteria,1RJJJ@1224|Proteobacteria,2W28X@28216|Betaproteobacteria,2KMV7@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3830535_0	234267.Acid_4289	4.767e-206	643.0	COG0673@1|root,COG0673@2|Bacteria,3Y6C9@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_3831548_2	47839.CCAU010000002_gene2335	1.578e-63	227.0	28PQS@1|root,2ZCCP@2|Bacteria,2IF0I@201174|Actinobacteria,236RC@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3831548_1	234267.Acid_1435	1.794e-118	391.0	COG5621@1|root,COG5621@2|Bacteria	2|Bacteria	S	spheroidene biosynthetic process	attH	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
TLS2_k127_3831548_0	234267.Acid_0738	3.125e-189	612.0	COG5316@1|root,COG5316@2|Bacteria,3Y46P@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
TLS2_k127_3831548_3	649638.Trad_1837	3.41e-18	88.0	COG4948@1|root,COG4948@2|Bacteria,1WMNA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Mandelate racemase muconate lactonizing enzyme	ykfB	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_3832899_1	1121949.AQXT01000002_gene2970	4.061e-05	51.0	COG0346@1|root,COG0346@2|Bacteria,1RG1A@1224|Proteobacteria,2U7AV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_3832899_0	234267.Acid_0069	4.772e-315	989.0	COG1391@1|root,COG1391@2|Bacteria,3Y72J@57723|Acidobacteria	57723|Acidobacteria	H	Glutamate-ammonia ligase adenylyltransferase	-	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
TLS2_k127_3834830_3	1353531.AZNX01000009_gene1030	2.784e-82	280.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat,V4R,XylR_N
TLS2_k127_3834830_5	1125718.HMPREF1318_2570	2.019e-07	62.0	COG1266@1|root,COG1266@2|Bacteria,2GMJ1@201174|Actinobacteria,4D32M@85005|Actinomycetales	201174|Actinobacteria	S	CAAX amino terminal protease family protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_3834830_1	203122.Sde_3061	7.4e-132	429.0	COG0726@1|root,COG0726@2|Bacteria,1R7W4@1224|Proteobacteria,1RXZE@1236|Gammaproteobacteria,468DS@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Polysaccharide deacetylase	xyn11B	-	-	-	-	-	-	-	-	-	-	-	CBM60,CBM_10,CBM_5_12_2,Glyco_hydro_11,Malectin,Polysacc_deac_1
TLS2_k127_3834830_0	926556.Echvi_1682	4.816e-264	844.0	COG3250@1|root,COG3250@2|Bacteria,4NF4T@976|Bacteroidetes	976|Bacteroidetes	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	Bgal_small_N,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TLS2_k127_3834830_2	743721.Psesu_0881	7.245e-107	357.0	COG0583@1|root,COG0583@2|Bacteria,1Q6E2@1224|Proteobacteria,1S4UZ@1236|Gammaproteobacteria,1X9AF@135614|Xanthomonadales	135614|Xanthomonadales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_3834830_4	240015.ACP_0868	1.526e-78	278.0	COG0745@1|root,COG0745@2|Bacteria,3Y2I8@57723|Acidobacteria,2JMD7@204432|Acidobacteriia	204432|Acidobacteriia	KT	Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	Malectin
TLS2_k127_3838148_15	1267533.KB906734_gene4335	3.201e-05	52.0	COG1629@1|root,COG4771@2|Bacteria,3Y3P9@57723|Acidobacteria,2JHUB@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_3838148_5	886293.Sinac_6981	5.401e-104	342.0	COG1131@1|root,COG1131@2|Bacteria,2IYQP@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3838148_2	251221.35213676	2.936e-167	539.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,DUF3526
TLS2_k127_3838148_3	251221.35213677	2.142e-134	443.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,DUF3526
TLS2_k127_3838148_9	251229.Chro_2173	4.793e-58	212.0	COG3386@1|root,COG3386@2|Bacteria,1G2S8@1117|Cyanobacteria,3VMV4@52604|Pleurocapsales	1117|Cyanobacteria	G	SMP-30/Gluconolaconase/LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
TLS2_k127_3838148_14	331869.BAL199_24894	1.542e-09	61.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2TR37@28211|Alphaproteobacteria,4BSDH@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Malate/L-lactate dehydrogenase	comC	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
TLS2_k127_3838148_6	331869.BAL199_24894	9.378e-92	309.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2TR37@28211|Alphaproteobacteria,4BSDH@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Malate/L-lactate dehydrogenase	comC	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
TLS2_k127_3838148_11	1340493.JNIF01000003_gene1429	1.251e-32	139.0	COG2137@1|root,COG2137@2|Bacteria	2|Bacteria	S	regulation of DNA repair	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
TLS2_k127_3838148_13	1340493.JNIF01000003_gene1428	1.597e-22	105.0	COG4980@1|root,COG4980@2|Bacteria,3Y5IA@57723|Acidobacteria	57723|Acidobacteria	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
TLS2_k127_3838148_4	1267535.KB906767_gene368	6.75e-133	434.0	COG0673@1|root,COG0673@2|Bacteria,3Y4KS@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_3838148_1	1267535.KB906767_gene3474	9.183e-186	585.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_3838148_16	861299.J421_1452	0.0005528	49.0	297M3@1|root,2ZUU3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3838148_8	234267.Acid_0319	2.581e-80	276.0	COG0705@1|root,COG0705@2|Bacteria,3Y4GU@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Rhomboid family	-	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid
TLS2_k127_3838148_10	402612.FP1223	3.968e-57	208.0	COG0569@1|root,COG0569@2|Bacteria,4PKFI@976|Bacteroidetes	976|Bacteroidetes	P	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
TLS2_k127_3838148_0	1267535.KB906767_gene423	0.0	1030.0	COG1649@1|root,COG1649@2|Bacteria,3Y6SC@57723|Acidobacteria,2JM8G@204432|Acidobacteriia	204432|Acidobacteriia	S	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
TLS2_k127_3838148_7	344747.PM8797T_13183	4.978e-84	293.0	COG2010@1|root,COG2010@2|Bacteria,2IYIY@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PSCyt1,PSCyt2,PSD1
TLS2_k127_3841295_2	1323663.AROI01000014_gene7	1.926e-23	104.0	COG0582@1|root,COG0582@2|Bacteria,1NX90@1224|Proteobacteria	1224|Proteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_3841295_0	1255043.TVNIR_0913	4.548e-62	229.0	COG4974@1|root,COG4974@2|Bacteria,1QUHS@1224|Proteobacteria,1S2C4@1236|Gammaproteobacteria,1X0IU@135613|Chromatiales	135613|Chromatiales	L	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_3841295_1	768671.ThimaDRAFT_4426	2.187e-46	182.0	COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria,1SQA0@1236|Gammaproteobacteria,1X16W@135613|Chromatiales	1224|Proteobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3843248_2	243090.RB4667	9.91e-28	118.0	COG1520@1|root,COG1520@2|Bacteria	243090.RB4667|-	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3843248_0	1313301.AUGC01000004_gene2301	6.003e-167	539.0	COG0179@1|root,COG0179@2|Bacteria,4NGI0@976|Bacteroidetes	976|Bacteroidetes	Q	Fumarylacetoacetase	fahA	-	3.7.1.2	ko:K01555	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FAA_hydrolase,FAA_hydrolase_N
TLS2_k127_3843248_1	1123073.KB899241_gene2071	1.054e-41	156.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,1RPGT@1236|Gammaproteobacteria,1X5HI@135614|Xanthomonadales	135614|Xanthomonadales	I	Acetyl-coenzyme A synthetase N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ACAS_N,AMP-binding
TLS2_k127_3852787_1	1379270.AUXF01000001_gene1897	3.733e-63	226.0	COG4454@1|root,COG4454@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
TLS2_k127_3852787_2	526225.Gobs_3536	5.243e-05	51.0	COG1917@1|root,COG1917@2|Bacteria,2IQI4@201174|Actinobacteria,4ET66@85013|Frankiales	201174|Actinobacteria	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_3852787_0	1267534.KB906760_gene1359	2.508e-135	439.0	COG2366@1|root,COG2366@2|Bacteria,3Y38M@57723|Acidobacteria,2JM6Q@204432|Acidobacteriia	204432|Acidobacteriia	S	Penicillin amidase	-	-	-	-	-	-	-	-	-	-	-	-	Penicil_amidase
TLS2_k127_3853628_2	234267.Acid_2590	2.311e-60	228.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,3Y5S6@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
TLS2_k127_3853628_5	234267.Acid_2589	1.973e-15	86.0	28U6K@1|root,2ZGCA@2|Bacteria,3Y8UV@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3853628_4	234267.Acid_2588	7.814e-18	93.0	290DP@1|root,2ZN31@2|Bacteria,3Y8WY@57723|Acidobacteria	57723|Acidobacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_3853628_3	234267.Acid_2587	6.089e-38	154.0	COG1595@1|root,COG1595@2|Bacteria,3Y87A@57723|Acidobacteria	57723|Acidobacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	-
TLS2_k127_3853628_1	379066.GAU_2025	1.174e-97	331.0	COG2355@1|root,COG2355@2|Bacteria,1ZU9D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
TLS2_k127_3853628_0	234267.Acid_7881	1.039e-108	359.0	COG0812@1|root,COG0812@2|Bacteria,3Y3AT@57723|Acidobacteria	57723|Acidobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
TLS2_k127_3860954_1	627192.SLG_32470	3.964e-92	306.0	28M5D@1|root,2ZAJ6@2|Bacteria,1R9NN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3860954_2	1500306.JQLA01000025_gene3443	4.439e-43	162.0	COG0784@1|root,COG0784@2|Bacteria,1N70P@1224|Proteobacteria,2UF5P@28211|Alphaproteobacteria,4BH80@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	response regulator	MA20_41525	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_3860954_0	1185652.USDA257_c19630	1.107e-155	497.0	COG3920@1|root,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2U4H4@28211|Alphaproteobacteria,4BM3Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS_9
TLS2_k127_3871194_1	344747.PM8797T_21913	3.876e-100	338.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_3871194_0	1198114.AciX9_2897	7.455e-124	416.0	COG1404@1|root,COG5164@1|root,COG1404@2|Bacteria,COG5164@2|Bacteria,3Y5WB@57723|Acidobacteria,2JK6I@204432|Acidobacteriia	204432|Acidobacteriia	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS2_k127_3878037_0	234267.Acid_3104	5.455e-205	664.0	COG4774@1|root,COG4774@2|Bacteria	2|Bacteria	P	siderophore transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_3878037_1	234267.Acid_7597	1.666e-139	451.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	bgaB	-	3.2.1.23	ko:K01190,ko:K12308	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_14,Glyco_hydro_42,Glyco_hydro_42M
TLS2_k127_3881451_3	379066.GAU_3508	5.619e-07	53.0	COG4584@1|root,COG4584@2|Bacteria,1ZV8R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_3881451_1	379066.GAU_3509	1.04e-37	147.0	COG1484@1|root,COG1484@2|Bacteria,1ZV5D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Bacterial dnaA  protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
TLS2_k127_3881451_0	1267535.KB906767_gene5374	3.644e-274	859.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_3883688_1	1340493.JNIF01000003_gene2671	4.437e-174	557.0	COG0593@1|root,COG0593@2|Bacteria,3Y2HA@57723|Acidobacteria	57723|Acidobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
TLS2_k127_3883688_2	234267.Acid_0002	2.681e-161	516.0	COG0592@1|root,COG0592@2|Bacteria,3Y2WE@57723|Acidobacteria	57723|Acidobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
TLS2_k127_3883688_0	234267.Acid_0003	1.258e-313	966.0	COG0187@1|root,COG0187@2|Bacteria,3Y369@57723|Acidobacteria	57723|Acidobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS2_k127_3885394_4	103690.17135456	3.717e-10	71.0	COG1413@1|root,COG5096@1|root,COG1413@2|Bacteria,COG5096@2|Bacteria,1G0UY@1117|Cyanobacteria,1HIS4@1161|Nostocales	1117|Cyanobacteria	C	NB-ARC domain	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC
TLS2_k127_3885394_3	234267.Acid_7654	5.518e-12	72.0	COG0629@1|root,COG0629@2|Bacteria,3Y4QE@57723|Acidobacteria	57723|Acidobacteria	L	PFAM single-strand binding protein Primosomal replication protein n	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_3885394_0	234267.Acid_6125	3.263e-51	188.0	COG1961@1|root,COG1961@2|Bacteria,3Y5HT@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_7,Resolvase
TLS2_k127_3885394_2	1249627.D779_0096	5.229e-39	150.0	2CFP1@1|root,32UTJ@2|Bacteria,1N7ZD@1224|Proteobacteria	1224|Proteobacteria	S	Calcium binding	-	-	-	-	-	-	-	-	-	-	-	-	Calci_bind_CcbP
TLS2_k127_3885394_1	1340493.JNIF01000004_gene1203	6.222e-47	175.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
TLS2_k127_3885469_6	234267.Acid_7465	1.593e-57	203.0	COG1298@1|root,COG1298@2|Bacteria,3Y3YR@57723|Acidobacteria	57723|Acidobacteria	NU	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
TLS2_k127_3885469_3	234267.Acid_7464	3.342e-89	305.0	COG1377@1|root,COG1377@2|Bacteria,3Y4JK@57723|Acidobacteria	57723|Acidobacteria	NU	FlhB HrpN YscU SpaS Family	-	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
TLS2_k127_3885469_5	234267.Acid_7463	9.193e-63	224.0	COG1684@1|root,COG1684@2|Bacteria,3Y8C9@57723|Acidobacteria	57723|Acidobacteria	NU	Bacterial export proteins, family 1	-	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
TLS2_k127_3885469_9	1283299.AUKG01000001_gene1694	4.075e-11	66.0	COG1987@1|root,COG1987@2|Bacteria,2IQ8H@201174|Actinobacteria,4CT8M@84995|Rubrobacteria	84995|Rubrobacteria	NU	Bacterial export proteins, family 3	-	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
TLS2_k127_3885469_2	234267.Acid_7461	1.09e-99	334.0	COG1338@1|root,COG1338@2|Bacteria,3Y3K4@57723|Acidobacteria	57723|Acidobacteria	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
TLS2_k127_3885469_7	234267.Acid_7460	5.434e-12	70.0	COG3190@1|root,COG3190@2|Bacteria	2|Bacteria	N	flagellar	fliO	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
TLS2_k127_3885469_10	1123355.JHYO01000016_gene1921	6.736e-06	51.0	COG1886@1|root,COG1886@2|Bacteria,1NNYT@1224|Proteobacteria,2USYA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	-	-	-	-	-	-	-	-	-	-	-	-	FliMN_C
TLS2_k127_3885469_1	234267.Acid_7458	1.751e-107	362.0	COG1749@1|root,COG1749@2|Bacteria,3Y3C0@57723|Acidobacteria	57723|Acidobacteria	N	Flagellar basal body protein FlaE	-	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
TLS2_k127_3885469_8	234267.Acid_7457	9.349e-12	72.0	COG1843@1|root,COG1843@2|Bacteria	2|Bacteria	N	Required for flagellar hook formation. May act as a scaffolding protein	flgD	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FLgD_tudor,FlgD,FlgD_ig
TLS2_k127_3885469_4	234267.Acid_7454	3.117e-68	240.0	COG4786@1|root,COG4786@2|Bacteria,3Y2HI@57723|Acidobacteria	57723|Acidobacteria	N	basal body rod protein	-	-	-	ko:K02391,ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TLS2_k127_3885469_0	234267.Acid_7453	1.719e-139	446.0	COG4786@1|root,COG4786@2|Bacteria,3Y3K1@57723|Acidobacteria	57723|Acidobacteria	N	flagellar basal-body rod protein FlgG	-	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TLS2_k127_3887374_0	1340493.JNIF01000003_gene3348	7.809e-123	401.0	COG3505@1|root,COG3505@2|Bacteria	2|Bacteria	U	unidirectional conjugation	traG	-	-	ko:K03205	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	T4SS-DNA_transf
TLS2_k127_3887374_1	1340493.JNIF01000003_gene3349	5.455e-118	391.0	COG4227@1|root,COG4227@2|Bacteria,3Y6Y0@57723|Acidobacteria	57723|Acidobacteria	L	Domain of unknown function (DUF1738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1738
TLS2_k127_3893739_2	882082.SaccyDRAFT_0025	9.505e-39	154.0	COG4759@1|root,COG4759@2|Bacteria,2GRSQ@201174|Actinobacteria,4DYIC@85010|Pseudonocardiales	201174|Actinobacteria	O	Sucrase/ferredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Suc_Fer-like
TLS2_k127_3893739_1	1267535.KB906767_gene365	1.346e-95	325.0	COG2017@1|root,COG2017@2|Bacteria,3Y4YM@57723|Acidobacteria	57723|Acidobacteria	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3893739_0	269799.Gmet_0751	1.336e-146	484.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,42N7D@68525|delta/epsilon subdivisions,2WKJS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,Inhibitor_I9,Peptidase_S8
TLS2_k127_3895912_1	1193181.BN10_1300016	1.156e-12	67.0	2DSQW@1|root,33H3S@2|Bacteria,2GTIV@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3895912_2	1382230.ASAP_2763	9.707e-11	66.0	2DPM9@1|root,332MQ@2|Bacteria,1NAPW@1224|Proteobacteria,2UWJH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3895912_3	237368.SCABRO_02775	1.627e-08	69.0	COG1361@1|root,COG3023@1|root,COG3064@1|root,COG3266@1|root,COG4412@1|root,COG1361@2|Bacteria,COG3023@2|Bacteria,COG3064@2|Bacteria,COG3266@2|Bacteria,COG4412@2|Bacteria,2J4CI@203682|Planctomycetes	203682|Planctomycetes	MV	Ami_2	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
TLS2_k127_3895912_0	1380390.JIAT01000014_gene6288	1.545e-29	139.0	COG0028@1|root,COG0515@1|root,COG1470@1|root,COG2133@1|root,COG3291@1|root,COG0028@2|Bacteria,COG0515@2|Bacteria,COG1470@2|Bacteria,COG2133@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	Calx-beta,DUF4347,GSDH,Laminin_G_3,PA14,PKD
TLS2_k127_3897643_3	639030.JHVA01000001_gene3980	0.0009174	44.0	COG2010@1|root,COG2010@2|Bacteria,3Y6YY@57723|Acidobacteria,2JMHW@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS2_k127_3897643_2	234267.Acid_0492	6.274e-71	244.0	COG2010@1|root,COG2010@2|Bacteria,3Y3HF@57723|Acidobacteria	57723|Acidobacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
TLS2_k127_3897643_0	1128421.JAGA01000003_gene2871	7.989e-220	693.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	nrfD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
TLS2_k127_3897643_1	472759.Nhal_2603	7.925e-131	422.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,1SYJH@1236|Gammaproteobacteria,1WWTE@135613|Chromatiales	135613|Chromatiales	C	PFAM 4Fe-4S	-	-	-	ko:K00184,ko:K21308	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	5.A.3	-	-	Fer4_11,Fer4_4,Fer4_7
TLS2_k127_3901791_1	234267.Acid_3128	1.293e-45	181.0	COG3942@1|root,COG3942@2|Bacteria	2|Bacteria	S	pathogenesis	gsp	-	3.5.1.78,6.3.1.8	ko:K01460	ko00480,ko01100,map00480,map01100	-	R01917,R01918	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	Big_2,CHAP,GBS_Bsp-like,GSP_synth
TLS2_k127_3901791_0	234267.Acid_0194	2.003e-57	214.0	COG1629@1|root,COG4771@2|Bacteria,3Y7GJ@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_390269_6	1267535.KB906767_gene2998	3.844e-158	504.0	COG0553@1|root,COG0553@2|Bacteria,3Y61F@57723|Acidobacteria	57723|Acidobacteria	L	SNF2 Helicase protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
TLS2_k127_390269_1	1267535.KB906767_gene2998	1.144e-271	841.0	COG0553@1|root,COG0553@2|Bacteria,3Y61F@57723|Acidobacteria	57723|Acidobacteria	L	SNF2 Helicase protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
TLS2_k127_390269_9	1267535.KB906767_gene2997	1.126e-109	361.0	COG4279@1|root,COG4279@2|Bacteria,3Y8KE@57723|Acidobacteria	57723|Acidobacteria	S	SWIM zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
TLS2_k127_390269_20	926550.CLDAP_15180	1.338e-24	112.0	COG1802@1|root,COG1802@2|Bacteria,2G97X@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional regulator, GntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_390269_0	234267.Acid_0194	0.0	1192.0	COG1629@1|root,COG4771@2|Bacteria,3Y7GJ@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_390269_5	497964.CfE428DRAFT_3506	3.393e-165	528.0	COG4409@1|root,COG4409@2|Bacteria,46SHF@74201|Verrucomicrobia	74201|Verrucomicrobia	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_390269_12	1267535.KB906767_gene5503	4.714e-69	246.0	COG0684@1|root,COG0684@2|Bacteria,3Y8I2@57723|Acidobacteria	57723|Acidobacteria	H	Pfam:Methyltransf_6	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
TLS2_k127_390269_10	234267.Acid_0192	7.497e-98	330.0	COG0329@1|root,COG0329@2|Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.1.3.3,4.3.3.7	ko:K01639,ko:K01714	ko00261,ko00300,ko00520,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00520,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R01811,R10147	RC00159,RC00600,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_390269_14	700598.Niako_0565	6.555e-55	206.0	COG0591@1|root,COG3055@1|root,COG0591@2|Bacteria,COG3055@2|Bacteria,4NEN8@976|Bacteroidetes,1J18W@117747|Sphingobacteriia	976|Bacteroidetes	E	COGs COG0591 Na proline symporter	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	Kelch_1,Kelch_5,Kelch_6,SSF
TLS2_k127_390269_17	1121459.AQXE01000014_gene366	2.325e-38	164.0	COG4409@1|root,COG4409@2|Bacteria,1PNKY@1224|Proteobacteria,42YPA@68525|delta/epsilon subdivisions,2WTIT@28221|Deltaproteobacteria,2M7SI@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_390269_15	886293.Sinac_5333	9.515e-52	192.0	COG0684@1|root,COG0684@2|Bacteria,2IYU5@203682|Planctomycetes	203682|Planctomycetes	H	Demethylmenaquinone methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
TLS2_k127_390269_16	234267.Acid_0195	2.99e-41	163.0	COG1802@1|root,COG1802@2|Bacteria,3Y849@57723|Acidobacteria	57723|Acidobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_390269_3	1267535.KB906767_gene942	1.709e-176	593.0	COG1629@1|root,COG4771@2|Bacteria,3Y2ZK@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_390269_18	479434.Sthe_0087	9.514e-35	145.0	COG0329@1|root,COG0329@2|Bacteria,2G6U3@200795|Chloroflexi,27Y9D@189775|Thermomicrobia	200795|Chloroflexi	H	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_390269_8	1122605.KB893625_gene2201	1.824e-124	416.0	COG0591@1|root,COG0591@2|Bacteria,4NEN8@976|Bacteroidetes,1INRR@117747|Sphingobacteriia	976|Bacteroidetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_390269_19	309801.trd_0311	2.757e-33	137.0	COG0684@1|root,COG0684@2|Bacteria,2GBDU@200795|Chloroflexi,27Z0W@189775|Thermomicrobia	189775|Thermomicrobia	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
TLS2_k127_390269_11	521674.Plim_3447	5.573e-79	276.0	COG4409@1|root,COG4409@2|Bacteria,2IX8T@203682|Planctomycetes	203682|Planctomycetes	G	BNR repeat-like domain	-	-	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2
TLS2_k127_390269_2	1166018.FAES_5039	1.684e-210	666.0	COG1053@1|root,COG1053@2|Bacteria,4NG56@976|Bacteroidetes,47NX7@768503|Cytophagia	976|Bacteroidetes	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_390269_7	64471.sync_2679	2.341e-133	441.0	COG0154@1|root,COG0154@2|Bacteria,1G0HS@1117|Cyanobacteria,1GZCX@1129|Synechococcus	1117|Cyanobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_390269_4	313628.LNTAR_21530	1.399e-171	554.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,CBM_35,F5_F8_type_C,GDE_C,NPCBM_assoc,RicinB_lectin_2,Trehalase
TLS2_k127_390269_13	1267535.KB906767_gene1814	6.051e-67	236.0	COG1629@1|root,COG4771@2|Bacteria,3Y7GJ@57723|Acidobacteria,2JM2Q@204432|Acidobacteriia	204432|Acidobacteriia	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_390271_1	1267535.KB906767_gene2223	2.532e-46	188.0	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	ko:K02847	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	Wzy_C
TLS2_k127_390271_0	63737.Npun_F2442	8.368e-64	233.0	COG2244@1|root,COG2244@2|Bacteria,1G07A@1117|Cyanobacteria,1HJIF@1161|Nostocales	1117|Cyanobacteria	S	PFAM polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
TLS2_k127_390271_2	1298880.AUEV01000001_gene5833	8.482e-15	87.0	COG2723@1|root,COG2723@2|Bacteria,2H2MI@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_1
TLS2_k127_3905937_0	1340493.JNIF01000003_gene3464	3.014e-141	469.0	COG1629@1|root,COG4771@2|Bacteria,3Y77Q@57723|Acidobacteria	57723|Acidobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_3905937_1	1122927.KB895431_gene78	1.841e-76	291.0	COG0383@1|root,COG2120@1|root,COG3210@1|root,COG4099@1|root,COG4733@1|root,COG5184@1|root,COG5276@1|root,COG0383@2|Bacteria,COG2120@2|Bacteria,COG3210@2|Bacteria,COG4099@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	3.2.1.24,3.4.24.40	ko:K01191,ko:K01406,ko:K20276	ko00511,ko01503,ko02024,map00511,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04131	-	GH38	-	Big_2,Cohesin,F5_F8_type_C,PIG-L,RCC1_2
TLS2_k127_3905937_4	387092.NIS_0753	0.0009704	53.0	COG4733@1|root,COG4733@2|Bacteria,1N010@1224|Proteobacteria,42M7U@68525|delta/epsilon subdivisions,2YM7Z@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Fibronectin type 3 domain-containing protein	-	-	-	ko:K06882	-	-	-	-	ko00000	-	-	-	fn3
TLS2_k127_3905937_2	1157635.KB892008_gene3604	3.435e-68	249.0	COG1635@1|root,COG1635@2|Bacteria	2|Bacteria	H	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur	thi4	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0018131,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0046872,GO:0046914,GO:0052837,GO:0052838,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	ko:K03146	ko00730,ko01100,map00730,map01100	-	R10685	RC00033,RC03253,RC03254	ko00000,ko00001	-	-	-	FAD_oxidored,Thi4
TLS2_k127_3905937_3	234267.Acid_5955	3.064e-52	198.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	1.1.1.292	ko:K19181	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_3908264_0	1340493.JNIF01000004_gene1163	3.725e-104	347.0	COG0553@1|root,COG0553@2|Bacteria,3Y7DC@57723|Acidobacteria	57723|Acidobacteria	KL	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3908264_1	1340493.JNIF01000004_gene1166	3.843e-62	220.0	COG0827@1|root,COG0827@2|Bacteria,3Y6GU@57723|Acidobacteria	57723|Acidobacteria	L	DNA restriction-modification system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3908566_0	234267.Acid_0877	6.907e-95	336.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
TLS2_k127_3908566_2	1123252.ATZF01000020_gene2933	1.609e-17	96.0	COG0515@1|root,COG0515@2|Bacteria,1VDRS@1239|Firmicutes,4HM2A@91061|Bacilli	91061|Bacilli	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS2_k127_3908566_1	1267535.KB906767_gene1954	5.228e-50	182.0	2AG8X@1|root,316EB@2|Bacteria,3Y75Y@57723|Acidobacteria,2JNUP@204432|Acidobacteriia	204432|Acidobacteriia	S	Plasmid encoded RepA protein	-	-	-	-	-	-	-	-	-	-	-	-	RepA_C
TLS2_k127_3908851_8	1408424.JHYI01000043_gene2868	1.856e-06	54.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_3908851_5	234267.Acid_1625	6.267e-43	169.0	COG2801@1|root,COG2801@2|Bacteria,3Y6NP@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
TLS2_k127_3908851_4	1121878.AUGL01000005_gene2685	1.651e-59	223.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	yebA	-	-	-	-	-	-	-	-	-	-	-	OapA,OapA_N,Peptidase_M23
TLS2_k127_3908851_3	234267.Acid_2455	8.939e-79	285.0	COG0515@1|root,COG0515@2|Bacteria	234267.Acid_2455|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3908851_0	234267.Acid_0024	7.921e-183	602.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_3908851_1	153721.MYP_2286	8.398e-162	522.0	COG3119@1|root,COG3119@2|Bacteria,4NFGI@976|Bacteroidetes,47ND1@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_3908851_2	1123242.JH636434_gene4791	2.22e-91	318.0	COG0673@1|root,COG0673@2|Bacteria,2IXRR@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_3908851_7	290318.Cvib_0631	8.098e-08	59.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1FEDE@1090|Chlorobi	1090|Chlorobi	H	May be the GTPase, regulating ATP sulfurylase activity	-	-	2.7.1.25,2.7.7.4	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
TLS2_k127_3908851_6	694431.DESACE_07825	6.34e-17	82.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2M6D7@213113|Desulfurellales	28221|Deltaproteobacteria	L	Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria	-	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS2_k127_3917373_3	272134.KB731324_gene972	1.889e-132	426.0	COG0562@1|root,COG0562@2|Bacteria,1G3KR@1117|Cyanobacteria,1HA1P@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM UDP-galactopyranose mutase, C-terminal	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	GLF,Glyco_trans_1_4,NAD_binding_8
TLS2_k127_3917373_2	1242864.D187_001873	3.83e-135	443.0	COG0438@1|root,COG0438@2|Bacteria,1QU2N@1224|Proteobacteria,42PY5@68525|delta/epsilon subdivisions,2WIU8@28221|Deltaproteobacteria,2YVJ5@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
TLS2_k127_3917373_1	179408.Osc7112_5141	1.037e-147	478.0	COG2723@1|root,COG2723@2|Bacteria,1GBD9@1117|Cyanobacteria,1HE57@1150|Oscillatoriales	1117|Cyanobacteria	G	6-phospho-beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3917373_5	234267.Acid_5778	1.073e-74	264.0	COG1295@1|root,COG1295@2|Bacteria,3Y7G1@57723|Acidobacteria	57723|Acidobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_3917373_0	234267.Acid_1118	1.345e-283	888.0	COG0457@1|root,COG1225@1|root,COG0457@2|Bacteria,COG1225@2|Bacteria,3Y3D1@57723|Acidobacteria	57723|Acidobacteria	O	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_3917373_4	234267.Acid_2115	4.215e-88	301.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,3Y59G@57723|Acidobacteria	57723|Acidobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,HTH_31
TLS2_k127_3917373_6	1340493.JNIF01000004_gene953	1.242e-67	235.0	COG1595@1|root,COG1595@2|Bacteria,3Y3BS@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_3917373_7	529818.AMSG_04502T0	9.083e-11	64.0	COG2352@1|root,2QPVS@2759|Eukaryota	2759|Eukaryota	C	phosphoenolpyruvate carboxylase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEPcase
TLS2_k127_3918262_4	1185876.BN8_06214	5.256e-96	326.0	COG2706@1|root,COG2706@2|Bacteria,4NE87@976|Bacteroidetes,47KQB@768503|Cytophagia	976|Bacteroidetes	G	PFAM 3-carboxy-cis,cis-muconate lactonizing enzyme	-	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactonase
TLS2_k127_3918262_1	1396141.BATP01000009_gene2639	1.971e-201	635.0	COG0477@1|root,COG2814@2|Bacteria,46Z9E@74201|Verrucomicrobia	74201|Verrucomicrobia	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_3918262_6	13035.Dacsa_2599	1.029e-60	215.0	COG0229@1|root,COG0229@2|Bacteria,1G5S6@1117|Cyanobacteria	1117|Cyanobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
TLS2_k127_3918262_5	234267.Acid_1392	6.006e-81	278.0	COG1134@1|root,COG1134@2|Bacteria	2|Bacteria	GM	teichoic acid transport	-	-	3.6.3.38,3.6.3.40	ko:K09689,ko:K09691,ko:K09693	ko02010,map02010	M00249,M00250,M00251	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.101,3.A.1.103,3.A.1.104	-	-	ABC_tran,LysM,Wzt_C
TLS2_k127_3918262_2	1340493.JNIF01000003_gene4568	5.051e-139	456.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	ko:K04786,ko:K12240,ko:K13613,ko:K15677	ko01053,map01053	-	-	-	ko00000,ko00001,ko01004,ko01008	-	-	-	ADH_N,ADH_zinc_N,AMP-binding,Acyl_transf_1,Condensation,Glyoxalase_4,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25,NUDIX,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
TLS2_k127_3918262_0	234267.Acid_0030	1.52e-251	800.0	COG1074@1|root,COG1074@2|Bacteria,3Y41J@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the helicase family. UvrD subfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS2_k127_3920369_3	1229780.BN381_50053	2.39e-13	75.0	COG2402@1|root,COG2402@2|Bacteria,2H9NW@201174|Actinobacteria	201174|Actinobacteria	S	toxic component of a	-	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045926,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_3920369_0	236097.ADG881_828	2.478e-28	117.0	COG3668@1|root,COG3668@2|Bacteria,1N8IJ@1224|Proteobacteria,1SDC1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG3668 Plasmid stabilization system protein	-	-	-	ko:K19092	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
TLS2_k127_3920369_2	1122212.AULO01000006_gene1795	8.303e-15	78.0	COG3609@1|root,COG3609@2|Bacteria,1NCCQ@1224|Proteobacteria,1SCIX@1236|Gammaproteobacteria,1XQSQ@135619|Oceanospirillales	135619|Oceanospirillales	K	Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH	-	-	-	-	-	-	-	-	-	-	-	-	ParD_antitoxin
TLS2_k127_3920664_0	857087.Metme_2942	2.727e-127	421.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1XDS9@135618|Methylococcales	135618|Methylococcales	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_3920664_1	357808.RoseRS_3409	5.488e-17	84.0	COG4636@1|root,COG4636@2|Bacteria	2|Bacteria	D	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS2_k127_3921964_12	1123288.SOV_1c09510	0.0002295	48.0	COG0845@1|root,COG0845@2|Bacteria,1V2JZ@1239|Firmicutes,4H2CU@909932|Negativicutes	909932|Negativicutes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TLS2_k127_3921964_8	401053.AciPR4_1929	4.624e-65	225.0	COG3865@1|root,COG3865@2|Bacteria,3Y4V2@57723|Acidobacteria,2JJFP@204432|Acidobacteriia	204432|Acidobacteriia	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
TLS2_k127_3921964_10	1123277.KB893172_gene631	6.66e-31	126.0	2DS0Y@1|root,32US3@2|Bacteria,4NS8W@976|Bacteroidetes,47R68@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3921964_9	926549.KI421517_gene3213	2.941e-53	190.0	COG2259@1|root,COG2259@2|Bacteria,4PB3J@976|Bacteroidetes,47V4B@768503|Cytophagia	976|Bacteroidetes	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
TLS2_k127_3921964_1	1340493.JNIF01000003_gene1385	0.0	1273.0	COG1629@1|root,COG4771@2|Bacteria,3Y2GB@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_3921964_11	234267.Acid_4929	6.011e-25	113.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,Copper-bind,Cytochrom_C,Cytochrome_CBB3,DUF1573,Laminin_G_3,ThuA
TLS2_k127_3921964_2	234267.Acid_0865	5.066e-231	730.0	COG0154@1|root,COG0154@2|Bacteria,3Y7E2@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Amidase	-	-	3.5.1.54,6.3.4.6	ko:K01457,ko:K01941	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005,R00774	RC00378,RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS2_k127_3921964_0	234267.Acid_0866	0.0	1574.0	COG0439@1|root,COG1984@1|root,COG2049@1|root,COG4770@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,COG4770@2|Bacteria,3Y7FI@57723|Acidobacteria	57723|Acidobacteria	EI	Allophanate hydrolase subunit 2	-	-	6.3.4.6	ko:K01941	ko00220,ko00791,ko01100,map00220,map00791,map01100	-	R00774	RC00378	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D
TLS2_k127_3921964_5	234267.Acid_0867	3.668e-108	353.0	COG3665@1|root,COG3665@2|Bacteria,3Y6FT@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF1989)	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
TLS2_k127_3921964_6	234267.Acid_0868	1.436e-103	344.0	COG3665@1|root,COG3665@2|Bacteria,3Y61C@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF1989)	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
TLS2_k127_3921964_3	1340493.JNIF01000004_gene11	3.935e-170	548.0	COG0591@1|root,COG0591@2|Bacteria,3Y8UG@57723|Acidobacteria	57723|Acidobacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_3921964_4	234267.Acid_0856	7.209e-134	441.0	COG3391@1|root,COG3391@2|Bacteria,3Y5TX@57723|Acidobacteria	57723|Acidobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_3921964_7	1340493.JNIF01000003_gene1388	2.786e-65	232.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3925465_2	1100720.ALKN01000062_gene1407	7.54e-30	119.0	COG4683@1|root,COG4683@2|Bacteria,1MZIY@1224|Proteobacteria,2VWKG@28216|Betaproteobacteria,4AIHW@80864|Comamonadaceae	28216|Betaproteobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
TLS2_k127_3925465_3	234267.Acid_5148	9.264e-20	93.0	COG3620@1|root,COG3620@2|Bacteria,3Y9AU@57723|Acidobacteria	57723|Acidobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_37
TLS2_k127_3925465_1	1267535.KB906767_gene1220	2.891e-77	270.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve,rve_3
TLS2_k127_3925465_4	1380355.JNIJ01000041_gene5260	6.333e-10	65.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,2U24Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
TLS2_k127_3925465_0	1267535.KB906767_gene5080	1.932e-104	351.0	COG1503@1|root,COG1503@2|Bacteria,3Y6P2@57723|Acidobacteria	57723|Acidobacteria	J	eRF1 domain 3	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach,eRF1_3
TLS2_k127_3943730_0	1267535.KB906767_gene942	1.638e-201	666.0	COG1629@1|root,COG4771@2|Bacteria,3Y2ZK@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_3943730_1	861299.J421_0410	1.114e-11	69.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_3945354_0	1340493.JNIF01000004_gene88	7.929e-241	771.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_3945354_1	234267.Acid_4014	1.366e-85	299.0	COG0673@1|root,COG0673@2|Bacteria,3Y4KS@57723|Acidobacteria	2|Bacteria	S	PFAM oxidoreductase domain protein	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_3945354_3	1340493.JNIF01000004_gene245	2.68e-40	159.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Calx-beta,CarboxypepD_reg,DUF1080,F5_F8_type_C,G5,G8,Glyco_hyd_101C,Glyco_hydro_101,Trypsin_2,YSIRK_signal,fn3
TLS2_k127_3945354_2	886293.Sinac_5724	9.92e-52	186.0	COG0662@1|root,COG0662@2|Bacteria,2J0CV@203682|Planctomycetes	203682|Planctomycetes	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_3946779_4	1122237.AUGQ01000020_gene611	3.037e-07	53.0	COG1674@1|root,COG1716@1|root,COG1674@2|Bacteria,COG1716@2|Bacteria,2GJBR@201174|Actinobacteria,4FKDQ@85023|Microbacteriaceae	201174|Actinobacteria	DT	FtsK/SpoIIIE family	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FHA,FtsK_SpoIIIE,Yop-YscD_cpl
TLS2_k127_3946779_3	234267.Acid_7501	2.128e-19	93.0	COG4961@1|root,COG4961@2|Bacteria	2|Bacteria	U	PFAM TadE family protein	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,TadE
TLS2_k127_3946779_2	234267.Acid_7595	1.586e-20	98.0	COG4961@1|root,COG4961@2|Bacteria,3Y95G@57723|Acidobacteria	57723|Acidobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS2_k127_3946779_1	234267.Acid_7503	7.018e-27	127.0	COG4655@1|root,COG4655@2|Bacteria,3Y5CX@57723|Acidobacteria	57723|Acidobacteria	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
TLS2_k127_3946779_5	1031711.RSPO_c02709	9.24e-05	48.0	COG3847@1|root,COG3847@2|Bacteria,1PIUF@1224|Proteobacteria,2W7DT@28216|Betaproteobacteria,1KEDP@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Flp/Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
TLS2_k127_3946779_0	234267.Acid_1409	1.405e-36	143.0	COG3745@1|root,COG3745@2|Bacteria,3Y4HR@57723|Acidobacteria	57723|Acidobacteria	U	PFAM SAF domain	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
TLS2_k127_3953641_1	234267.Acid_4014	4.881e-28	119.0	COG0673@1|root,COG0673@2|Bacteria,3Y4KS@57723|Acidobacteria	2|Bacteria	S	PFAM oxidoreductase domain protein	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_3953641_0	378806.STAUR_7749	1.161e-30	137.0	COG0739@1|root,COG0739@2|Bacteria,1NJ25@1224|Proteobacteria	1224|Proteobacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3959754_2	1340493.JNIF01000003_gene3362	2.644e-36	139.0	COG3451@1|root,COG3451@2|Bacteria,3Y2WX@57723|Acidobacteria	57723|Acidobacteria	U	type IV secretory pathway VirB4	-	-	-	ko:K03199	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	CagE_TrbE_VirB,DUF87
TLS2_k127_3959754_1	1340493.JNIF01000003_gene3363	8.748e-97	322.0	COG5314@1|root,COG5314@2|Bacteria	2|Bacteria	U	conjugation	trbJ	-	-	ko:K20266	ko02024,map02024	-	-	-	ko00000,ko00001,ko02044	3.A.7.4	-	-	DUF2749
TLS2_k127_3959754_0	1340493.JNIF01000003_gene3365	3.076e-156	504.0	COG3846@1|root,COG3846@2|Bacteria	2|Bacteria	U	protein secretion by the type IV secretion system	trbL	-	-	ko:K03201,ko:K07344,ko:K12052,ko:K21471	ko02024,ko03070,map02024,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko02044	3.A.7,3.A.7.4,3.A.7.8.1	-	-	Peptidase_M23,TrbL
TLS2_k127_3960212_0	234267.Acid_6644	8.132e-293	908.0	COG0322@1|root,COG0322@2|Bacteria,3Y2Y7@57723|Acidobacteria	57723|Acidobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
TLS2_k127_3960212_1	234267.Acid_7283	1.515e-150	482.0	COG0438@1|root,COG0438@2|Bacteria,3Y3CI@57723|Acidobacteria	57723|Acidobacteria	M	glycosyl transferase group 1	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_3962472_6	1121439.dsat_1890	1.569e-05	47.0	COG2227@1|root,COG2227@2|Bacteria,1RKH0@1224|Proteobacteria,42Q2I@68525|delta/epsilon subdivisions,2WJME@28221|Deltaproteobacteria,2M9G0@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM Methyltransferase type	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS2_k127_3962472_5	234267.Acid_1980	1.412e-09	61.0	COG0707@1|root,COG1819@1|root,COG0707@2|Bacteria,COG1819@2|Bacteria,3Y60F@57723|Acidobacteria	57723|Acidobacteria	CG	TIGRFAM glycosyltransferase, MGT family	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
TLS2_k127_3962472_4	909613.UO65_3371	4.044e-31	138.0	COG0304@1|root,COG0304@2|Bacteria,2GIY4@201174|Actinobacteria	201174|Actinobacteria	IQ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS2_k127_3962472_3	204669.Acid345_4577	4.551e-54	204.0	COG1566@1|root,COG1566@2|Bacteria,3Y6U1@57723|Acidobacteria,2JKUF@204432|Acidobacteriia	204432|Acidobacteriia	V	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	HlyD_D23
TLS2_k127_3962472_2	1267533.KB906740_gene157	6.455e-89	306.0	COG1131@1|root,COG1131@2|Bacteria,3Y3PY@57723|Acidobacteria,2JIQU@204432|Acidobacteriia	204432|Acidobacteriia	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3962472_1	204669.Acid345_4575	1.582e-116	385.0	COG0842@1|root,COG1511@1|root,COG0842@2|Bacteria,COG1511@2|Bacteria,3Y65Z@57723|Acidobacteria,2JM5S@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_3962472_0	886293.Sinac_2688	8.328e-133	430.0	COG3379@1|root,COG3379@2|Bacteria,2IYF3@203682|Planctomycetes	2|Bacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_3967535_10	519989.ECTPHS_13547	1.434e-126	414.0	COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,1RNAP@1236|Gammaproteobacteria,1WW6T@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase family 4	-	-	-	ko:K13007	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
TLS2_k127_3967535_12	395494.Galf_2831	7.067e-98	329.0	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,2VJHC@28216|Betaproteobacteria,44VIG@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Male sterility protein	wbiG	-	1.1.1.219,5.1.3.2	ko:K00091,ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS2_k127_3967535_9	1114970.PSF113_1654	3.991e-130	428.0	COG0438@1|root,COG0438@2|Bacteria,1MY5T@1224|Proteobacteria,1RYAI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glycos_transf_1
TLS2_k127_3967535_2	768671.ThimaDRAFT_0419	5.511e-183	586.0	COG5360@1|root,COG5360@2|Bacteria,1MUJ4@1224|Proteobacteria,1RR5T@1236|Gammaproteobacteria,1WWS6@135613|Chromatiales	135613|Chromatiales	S	Heparinase II/III N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III,Hepar_II_III_N
TLS2_k127_3967535_23	1121422.AUMW01000016_gene2073	4.943e-60	222.0	COG0438@1|root,COG0438@2|Bacteria,1V5G1@1239|Firmicutes,24ICE@186801|Clostridia	186801|Clostridia	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
TLS2_k127_3967535_31	861299.J421_0857	2.031e-27	125.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	-	ko:K16554,ko:K21473	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011,ko02000	8.A.3.1	-	-	GNVR,NLPC_P60,Peptidase_M23,Wzz
TLS2_k127_3967535_30	1496688.ER33_00500	1.825e-30	130.0	COG4627@1|root,COG4627@2|Bacteria,1G9TC@1117|Cyanobacteria	1117|Cyanobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
TLS2_k127_3967535_28	411471.SUBVAR_06531	6.655e-38	157.0	COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia,3WHNS@541000|Ruminococcaceae	186801|Clostridia	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_3967535_14	349124.Hhal_0777	1.292e-88	305.0	COG0438@1|root,COG0438@2|Bacteria,1PIF6@1224|Proteobacteria	1224|Proteobacteria	M	Pfam Glycosyl transferases group 1	walM	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_3967535_0	1479238.JQMZ01000001_gene1911	1.101e-214	687.0	COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,1MZIG@1224|Proteobacteria,2UB61@28211|Alphaproteobacteria,43YUF@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_3967535_22	929703.KE386491_gene2287	4.651e-62	236.0	COG1132@1|root,COG1132@2|Bacteria,4NE2D@976|Bacteroidetes,47JQI@768503|Cytophagia	976|Bacteroidetes	V	ABC transporter transmembrane region	msbA	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_3967535_24	349521.HCH_01052	4.594e-48	184.0	COG1216@1|root,COG1216@2|Bacteria,1N8WS@1224|Proteobacteria,1SZ5M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_3967535_33	863365.XHC_0639	3.427e-11	72.0	COG0515@1|root,COG2227@1|root,COG0515@2|Bacteria,COG2227@2|Bacteria,1Q23S@1224|Proteobacteria,1RNW0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	HKLT	Methyltransferase domain	wxcB	-	2.1.1.294,2.7.1.181	ko:K18827	-	-	R10657,R10658	RC00002,RC00003,RC00078,RC03220	ko00000,ko01000,ko01005	-	-	-	APH,Methyltransf_31
TLS2_k127_3967535_32	945543.VIBR0546_16441	1.613e-20	106.0	COG3562@1|root,COG3562@2|Bacteria,1NKS0@1224|Proteobacteria,1T09F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	capsule polysaccharide	-	-	-	-	-	-	-	-	-	-	-	-	Capsule_synth
TLS2_k127_3967535_27	1122164.JHWF01000011_gene2485	1.003e-40	161.0	COG1670@1|root,COG1670@2|Bacteria,1N9TX@1224|Proteobacteria	1224|Proteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_3967535_19	1232437.KL662017_gene519	3.113e-67	243.0	COG1817@1|root,COG1817@2|Bacteria,1Q8CI@1224|Proteobacteria,43EGE@68525|delta/epsilon subdivisions,2WXCQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF354)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3967535_15	1122164.JHWF01000011_gene2483	5.27e-83	288.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	afr	-	1.1.1.292	ko:K19181	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_3967535_13	1122164.JHWF01000011_gene2482	6.51e-94	314.0	COG1861@1|root,COG1861@2|Bacteria,1PHID@1224|Proteobacteria,1RX64@1236|Gammaproteobacteria,1JGGB@118969|Legionellales	118969|Legionellales	M	Cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_3
TLS2_k127_3967535_5	1122164.JHWF01000011_gene2481	4.93e-158	509.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RPFX@1236|Gammaproteobacteria,1JEJS@118969|Legionellales	118969|Legionellales	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_3967535_26	335541.Swol_0200	5.635e-43	167.0	COG1670@1|root,COG1670@2|Bacteria,1VJ0E@1239|Firmicutes	1239|Firmicutes	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_3967535_18	349521.HCH_04825	7.939e-72	251.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,1XIEI@135619|Oceanospirillales	1236|Gammaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	-	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS2_k127_3967535_25	1121430.JMLG01000005_gene774	2.571e-46	174.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,260M0@186807|Peptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS2_k127_3967535_3	1122164.JHWF01000011_gene2474	4.259e-163	524.0	COG0037@1|root,COG0037@2|Bacteria,1NKHX@1224|Proteobacteria,1SZDS@1236|Gammaproteobacteria,1JGN0@118969|Legionellales	118969|Legionellales	D	ATPase of the PP-loop superfamily implicated in cell cycle control	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3967535_6	477974.Daud_1772	7.062e-153	490.0	COG2089@1|root,COG2089@2|Bacteria,1TS09@1239|Firmicutes,249DN@186801|Clostridia,2621V@186807|Peptococcaceae	186801|Clostridia	M	TIGRFAM pseudaminic acid synthase	pseI	-	2.5.1.56,2.5.1.97	ko:K01654,ko:K15898	ko00520,ko01100,map00520,map01100	-	R01804,R04435,R09841	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
TLS2_k127_3967535_17	644282.Deba_2768	1.172e-78	270.0	COG0223@1|root,COG0223@2|Bacteria,1N4Z4@1224|Proteobacteria,42UF3@68525|delta/epsilon subdivisions	1224|Proteobacteria	J	Formyl transferase	-	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_N
TLS2_k127_3967535_20	383372.Rcas_0775	1.966e-65	238.0	COG1670@1|root,COG3980@1|root,COG1670@2|Bacteria,COG3980@2|Bacteria	2|Bacteria	M	transferase activity, transferring hexosyl groups	pseG	-	3.6.1.57	ko:K15897	ko00520,map00520	-	R09834	RC00005,RC00078	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_3,Glyco_tran_28_C
TLS2_k127_3967535_1	323098.Nwi_2388	3.267e-183	583.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TU8Q@28211|Alphaproteobacteria,3K5YG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_3967535_16	439235.Dalk_0629	6.571e-82	281.0	COG0001@1|root,COG1861@1|root,COG0001@2|Bacteria,COG1861@2|Bacteria,1MUY5@1224|Proteobacteria,42NVU@68525|delta/epsilon subdivisions,2WMH6@28221|Deltaproteobacteria,2MNBA@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Aminotransferase class-III	-	-	2.6.1.111,5.4.3.8	ko:K01845,ko:K07257,ko:K21585	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272,R11607	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,CTP_transf_3
TLS2_k127_3967535_11	1121438.JNJA01000011_gene1821	2.107e-106	360.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,42SMJ@68525|delta/epsilon subdivisions,2WPNK@28221|Deltaproteobacteria,2MGSQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_3967535_4	1521187.JPIM01000048_gene86	1.514e-161	518.0	COG0399@1|root,COG0399@2|Bacteria,2G7XI@200795|Chloroflexi	200795|Chloroflexi	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_3967535_7	1121456.ATVA01000015_gene2476	6.906e-143	460.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42M4P@68525|delta/epsilon subdivisions,2WIKX@28221|Deltaproteobacteria,2M9KK@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Polysaccharide biosynthesis protein	pseB	-	4.2.1.115	ko:K15894	ko00520,map00520	-	R09697	RC02609	ko00000,ko00001,ko01000	-	-	-	Polysacc_synt_2
TLS2_k127_3967535_8	443144.GM21_2582	8.219e-132	444.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42MMR@68525|delta/epsilon subdivisions,2WJEB@28221|Deltaproteobacteria,43TVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	GM	Polysaccharide biosynthesis protein CapD	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
TLS2_k127_3967535_21	1283300.ATXB01000001_gene2220	1.064e-63	227.0	COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,1S245@1236|Gammaproteobacteria,1XF1P@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
TLS2_k127_3967535_29	1026882.MAMP_03055	1.636e-32	127.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,1RMTR@1236|Gammaproteobacteria,45ZYX@72273|Thiotrichales	72273|Thiotrichales	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_3968036_5	1340493.JNIF01000003_gene3349	1.592e-18	90.0	COG4227@1|root,COG4227@2|Bacteria,3Y6Y0@57723|Acidobacteria	57723|Acidobacteria	L	Domain of unknown function (DUF1738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1738
TLS2_k127_3968036_0	1340493.JNIF01000003_gene3348	3.365e-293	913.0	COG3505@1|root,COG3505@2|Bacteria	2|Bacteria	U	unidirectional conjugation	traG	-	-	ko:K03205	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	T4SS-DNA_transf
TLS2_k127_3968036_2	1340493.JNIF01000003_gene3347	6.967e-41	155.0	COG0629@1|root,COG0629@2|Bacteria	2|Bacteria	L	single-stranded DNA binding	ssbB	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_3968036_1	1340493.JNIF01000003_gene3346	9.308e-43	163.0	COG4959@1|root,COG4959@2|Bacteria	2|Bacteria	OU	Type IV secretory pathway protease TraF	traF	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S26
TLS2_k127_3968036_3	1547437.LL06_04015	5.528e-38	159.0	COG0388@1|root,COG0388@2|Bacteria,1RJE6@1224|Proteobacteria,2UDTM@28211|Alphaproteobacteria,43MR4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS2_k127_3968036_6	1442598.JABW01000030_gene1388	3.397e-07	57.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TLS2_k127_3968036_4	1410608.JNKX01000052_gene1502	1.714e-35	143.0	COG3385@1|root,COG3385@2|Bacteria,4NXT2@976|Bacteroidetes,2FRVS@200643|Bacteroidia	976|Bacteroidetes	L	hmm pf01609	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
TLS2_k127_3973658_1	378806.STAUR_5050	3.988e-49	179.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,42P5X@68525|delta/epsilon subdivisions,2WIQW@28221|Deltaproteobacteria,2YU6V@29|Myxococcales	28221|Deltaproteobacteria	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS2_k127_3973658_0	1183438.GKIL_2901	5.534e-91	327.0	COG0515@1|root,COG0515@2|Bacteria,1G3GV@1117|Cyanobacteria	1183438.GKIL_2901|-	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
TLS2_k127_3973658_2	234267.Acid_7677	1.37e-33	137.0	COG1595@1|root,COG1595@2|Bacteria,3Y7UW@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_3975785_3	497964.CfE428DRAFT_4921	2.548e-12	76.0	COG3203@1|root,COG3203@2|Bacteria,46SY8@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TLS2_k127_3975785_1	234267.Acid_1108	9.242e-72	260.0	COG0666@1|root,COG1657@1|root,COG0666@2|Bacteria,COG1657@2|Bacteria,3Y83C@57723|Acidobacteria	2|Bacteria	I	Ankyrin repeats (many copies)	-	-	3.5.1.81	ko:K06015,ko:K06867,ko:K06886	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,Prenyltrans,SQHop_cyclase_C,YkuD
TLS2_k127_3975785_0	264462.Bd3076	3.396e-121	400.0	COG0861@1|root,COG0861@2|Bacteria,1MUNR@1224|Proteobacteria,42PJP@68525|delta/epsilon subdivisions,2MTGD@213481|Bdellovibrionales,2WJI0@28221|Deltaproteobacteria	213481|Bdellovibrionales	P	membrane protein, TerC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
TLS2_k127_3975785_2	1267535.KB906767_gene1488	2.331e-19	90.0	COG3027@1|root,COG3027@2|Bacteria,3Y8Q5@57723|Acidobacteria	57723|Acidobacteria	D	Cell division protein ZapA	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
TLS2_k127_3978929_3	1340493.JNIF01000003_gene2101	1.002e-24	107.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	CMAS,MTS,Methyltransf_23,Methyltransf_25,Methyltransf_31
TLS2_k127_3978929_1	1340493.JNIF01000003_gene2100	4.95e-154	497.0	2EXCM@1|root,33QP8@2|Bacteria,3Y730@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3978929_2	234267.Acid_7906	1.987e-59	213.0	COG0629@1|root,COG0629@2|Bacteria,3Y4D2@57723|Acidobacteria	57723|Acidobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_3978929_0	234267.Acid_7294	1.273e-162	530.0	COG1629@1|root,COG4771@2|Bacteria,3Y7CC@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_3992610_0	240016.ABIZ01000001_gene4353	4.263e-193	619.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TLS2_k127_3992610_1	28072.Nos7524_3633	8.71e-127	419.0	COG3547@1|root,COG3547@2|Bacteria,1GA7N@1117|Cyanobacteria,1HTM7@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_3993959_0	1469245.JFBG01000083_gene252	1.601e-63	229.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1RRTD@1236|Gammaproteobacteria,1X1ZG@135613|Chromatiales	135613|Chromatiales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_3995534_2	1041147.AUFB01000038_gene4071	1.15e-27	115.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2TVFI@28211|Alphaproteobacteria,4B7J0@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	DNA invertase Pin	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_3995534_1	1267535.KB906767_gene5374	3.419e-119	390.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_3995534_0	1403819.BATR01000195_gene6595	1.536e-127	429.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TLS2_k127_4002849_2	234267.Acid_5839	1.017e-94	324.0	COG0477@1|root,COG2814@2|Bacteria,3Y71R@57723|Acidobacteria	57723|Acidobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_4002849_0	234267.Acid_5840	5.067e-164	520.0	COG0180@1|root,COG0180@2|Bacteria,3Y2VN@57723|Acidobacteria	57723|Acidobacteria	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS2_k127_4002849_1	234267.Acid_5841	1.344e-125	413.0	COG2265@1|root,COG2265@2|Bacteria,3Y3SF@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
TLS2_k127_4009562_1	331869.BAL199_28695	5.394e-58	205.0	COG3328@1|root,COG3328@2|Bacteria,1R81T@1224|Proteobacteria,2TT28@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3328 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
TLS2_k127_4009562_0	1354314.CHV_a0267	5.425e-129	428.0	COG3344@1|root,COG3344@2|Bacteria,4NHMS@976|Bacteroidetes,47X91@768503|Cytophagia	976|Bacteroidetes	L	Group II intron, maturase-specific domain	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,HNH,Intron_maturas2,RVT_1,RVT_N
TLS2_k127_4010381_0	1196323.ALKF01000197_gene2265	5.799e-78	275.0	COG3119@1|root,COG3119@2|Bacteria,1UDRD@1239|Firmicutes,4HD9J@91061|Bacilli,26R87@186822|Paenibacillaceae	91061|Bacilli	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_4010381_1	1340493.JNIF01000003_gene1328	1.445e-71	248.0	COG1682@1|root,COG1682@2|Bacteria	2|Bacteria	GM	macromolecule localization	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
TLS2_k127_402733_3	234267.Acid_5817	3.817e-40	157.0	COG1514@1|root,COG1514@2|Bacteria,3Y5Y2@57723|Acidobacteria	57723|Acidobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
TLS2_k127_402733_5	1267535.KB906767_gene4298	1.104e-25	109.0	2FE1U@1|root,34620@2|Bacteria,3Y8MC@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_402733_4	234267.Acid_1395	1.036e-33	141.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Fer4_15,Patatin
TLS2_k127_402733_2	1267535.KB906767_gene4531	2.271e-40	156.0	COG2442@1|root,COG2442@2|Bacteria,3Y828@57723|Acidobacteria	57723|Acidobacteria	S	InterPro IPR007367	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_402733_0	234267.Acid_2636	5.435e-105	355.0	COG0845@1|root,COG0845@2|Bacteria,3Y43D@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
TLS2_k127_402733_6	1340493.JNIF01000003_gene2637	5.919e-22	110.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new,TonB_C
TLS2_k127_402733_1	234267.Acid_1921	2.685e-44	166.0	COG3852@1|root,COG3852@2|Bacteria,3Y9A1@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_4038842_0	234267.Acid_7158	2.49e-217	683.0	COG1215@1|root,COG2227@1|root,COG1215@2|Bacteria,COG2227@2|Bacteria,3Y6IT@57723|Acidobacteria	57723|Acidobacteria	HM	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_12
TLS2_k127_4038842_1	234267.Acid_0586	8.053e-41	169.0	COG5373@1|root,COG5373@2|Bacteria,3Y44X@57723|Acidobacteria	57723|Acidobacteria	NU	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
TLS2_k127_4038991_14	1340493.JNIF01000003_gene2877	2.597e-05	51.0	COG0666@1|root,COG0666@2|Bacteria,3Y6UE@57723|Acidobacteria	57723|Acidobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2
TLS2_k127_4038991_8	290397.Adeh_1181	3.188e-79	273.0	COG1573@1|root,COG1573@2|Bacteria,1MW8T@1224|Proteobacteria,42ZZ6@68525|delta/epsilon subdivisions,2WV5A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_4038991_0	234267.Acid_0351	2.148e-285	899.0	COG3250@1|root,COG3250@2|Bacteria,3Y48R@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glyco_hydro_2_N
TLS2_k127_4038991_2	234267.Acid_5024	6.812e-140	477.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_4038991_1	1267535.KB906767_gene4530	3.267e-175	558.0	COG3875@1|root,COG3875@2|Bacteria,3Y6SH@57723|Acidobacteria,2JKUN@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
TLS2_k127_4038991_11	760568.Desku_1452	3.114e-24	114.0	COG0500@1|root,COG2226@2|Bacteria,1TQUF@1239|Firmicutes,25E3F@186801|Clostridia,261W3@186807|Peptococcaceae	186801|Clostridia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_4038991_10	240015.ACP_0992	1.138e-25	114.0	COG0457@1|root,COG0457@2|Bacteria	240015.ACP_0992|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4038991_4	1121904.ARBP01000021_gene3579	4.05e-133	440.0	COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,47JYR@768503|Cytophagia	976|Bacteroidetes	P	PFAM sulfatase	mdsA	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_4038991_6	1163617.SCD_n00415	1.049e-112	373.0	COG3210@1|root,COG3210@2|Bacteria,1QVC2@1224|Proteobacteria,2VSG1@28216|Betaproteobacteria	28216|Betaproteobacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Haemagg_act,VPEP
TLS2_k127_4038991_9	366602.Caul_4758	1.264e-34	139.0	COG3727@1|root,COG3727@2|Bacteria,1RH1C@1224|Proteobacteria,2UA6G@28211|Alphaproteobacteria,2KGWM@204458|Caulobacterales	204458|Caulobacterales	L	May nick specific sequences that contain T G mispairs resulting from m5C-deamination	-	-	-	ko:K07458	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Vsr
TLS2_k127_4038991_3	913865.DOT_5513	2.461e-139	454.0	COG0270@1|root,COG0270@2|Bacteria	2|Bacteria	L	DNA (cytosine-5-)-methyltransferase activity	dcm	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
TLS2_k127_4038991_5	756272.Plabr_2636	5.018e-128	422.0	28J2H@1|root,2Z8YZ@2|Bacteria,2IWTN@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4038991_12	391612.CY0110_29244	3.049e-11	67.0	2EIT4@1|root,33CIF@2|Bacteria,1GGNK@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
TLS2_k127_4038991_13	1140.Synpcc7942_1210	3.669e-11	65.0	2C5EY@1|root,32YQJ@2|Bacteria,1GFQ4@1117|Cyanobacteria,1H3KH@1129|Synechococcus	1117|Cyanobacteria	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
TLS2_k127_4048501_1	1282361.ABAC402_02025	7.198e-86	293.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2TRJX@28211|Alphaproteobacteria,2KFPM@204458|Caulobacterales	204458|Caulobacterales	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
TLS2_k127_4048501_3	161156.JQKW01000012_gene21	2.549e-18	93.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,2GGVM@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
TLS2_k127_4048501_0	1047013.AQSP01000144_gene802	6.86e-90	303.0	COG3836@1|root,COG3836@2|Bacteria	2|Bacteria	G	2-keto-3-deoxy-L-rhamnonate aldolase activity	-	-	4.1.2.20,4.1.2.52	ko:K01630,ko:K02510	ko00053,ko00350,ko01120,map00053,map00350,map01120	-	R01645,R01647,R02754,R03277	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_4048501_4	1123070.KB899256_gene2191	9.685e-08	55.0	COG1028@1|root,COG1028@2|Bacteria,46UZ1@74201|Verrucomicrobia,2ITQR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_4054784_8	323098.Nwi_2796	3.219e-35	141.0	COG2032@1|root,COG2032@2|Bacteria,1RGV4@1224|Proteobacteria,2UC22@28211|Alphaproteobacteria,3JZIX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodC	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
TLS2_k127_4054784_4	1408224.SAMCCGM7_c1524	4.178e-79	276.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2TVGG@28211|Alphaproteobacteria,4BCEZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_4054784_6	1267535.KB906767_gene5194	2.258e-60	214.0	COG0494@1|root,COG0494@2|Bacteria,3Y4N9@57723|Acidobacteria,2JJ9X@204432|Acidobacteriia	204432|Acidobacteriia	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TLS2_k127_4054784_7	404589.Anae109_3061	1.377e-52	195.0	COG5522@1|root,COG5522@2|Bacteria,1QM2T@1224|Proteobacteria,435G9@68525|delta/epsilon subdivisions,2WZTR@28221|Deltaproteobacteria,2Z2QR@29|Myxococcales	28221|Deltaproteobacteria	S	Integral membrane protein (intg_mem_TP0381)	-	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
TLS2_k127_4054784_5	234267.Acid_3962	4.27e-78	271.0	COG1028@1|root,COG1028@2|Bacteria,3Y7MJ@57723|Acidobacteria	57723|Acidobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_4054784_0	344747.PM8797T_11626	1.074e-166	537.0	2EZBQ@1|root,33SH2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4054784_1	1121904.ARBP01000013_gene373	8.04e-111	394.0	COG2730@1|root,COG2730@2|Bacteria,4P1NI@976|Bacteroidetes,47TT8@768503|Cytophagia	976|Bacteroidetes	G	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038,DUF5060
TLS2_k127_4054784_2	760192.Halhy_0910	1.984e-110	393.0	COG5297@1|root,COG5297@2|Bacteria,4NG19@976|Bacteroidetes,1IRI2@117747|Sphingobacteriia	976|Bacteroidetes	G	Protein of unknown function (DUF1593)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1593,DUF5060
TLS2_k127_4054784_3	234267.Acid_6465	1.046e-98	359.0	COG1629@1|root,COG4771@2|Bacteria,3Y33S@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_4054784_9	1280944.HY17_18820	1.05e-11	74.0	2DR6B@1|root,33ACQ@2|Bacteria,1NI4T@1224|Proteobacteria,2UKEW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4056002_4	1267535.KB906767_gene656	4.729e-98	324.0	COG1032@1|root,COG1032@2|Bacteria,3Y2FN@57723|Acidobacteria,2JI6W@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_4056002_2	240015.ACP_0022	9.316e-108	361.0	COG1609@1|root,COG1609@2|Bacteria,3Y2ZZ@57723|Acidobacteria,2JIJV@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	GntR,Peripla_BP_3
TLS2_k127_4056002_0	234267.Acid_4350	3.883e-121	398.0	COG0560@1|root,COG0560@2|Bacteria,3Y6IV@57723|Acidobacteria	57723|Acidobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
TLS2_k127_4056002_6	204669.Acid345_1509	7.439e-14	73.0	293PJ@1|root,2ZR58@2|Bacteria,3Y96W@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4056002_5	28072.Nos7524_4650	9.395e-34	134.0	COG0415@1|root,COG0415@2|Bacteria,1G560@1117|Cyanobacteria,1HNEW@1161|Nostocales	1117|Cyanobacteria	L	Belongs to the DNA photolyase family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4056002_1	204669.Acid345_3766	3.477e-114	383.0	COG0312@1|root,COG0312@2|Bacteria,3Y7SM@57723|Acidobacteria	57723|Acidobacteria	L	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
TLS2_k127_4056002_3	204669.Acid345_3767	3.13e-99	326.0	COG0312@1|root,COG0312@2|Bacteria,3Y6TF@57723|Acidobacteria	57723|Acidobacteria	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS2_k127_4062038_4	204669.Acid345_3039	1.737e-58	207.0	28NTH@1|root,2ZBS4@2|Bacteria,3Y3NN@57723|Acidobacteria,2JIEU@204432|Acidobacteriia	204432|Acidobacteriia	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TLS2_k127_4062038_5	234267.Acid_2503	3.285e-48	184.0	COG1438@1|root,COG1438@2|Bacteria,3Y551@57723|Acidobacteria	57723|Acidobacteria	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
TLS2_k127_4062038_2	234267.Acid_2504	2.552e-210	662.0	COG0165@1|root,COG0165@2|Bacteria,3Y36Y@57723|Acidobacteria	57723|Acidobacteria	E	TIGRFAM argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
TLS2_k127_4062038_0	1267535.KB906767_gene4529	3.474e-229	713.0	COG0137@1|root,COG0137@2|Bacteria,3Y4Y9@57723|Acidobacteria,2JJKA@204432|Acidobacteriia	204432|Acidobacteriia	E	Arginosuccinate synthase	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
TLS2_k127_4062038_3	1340493.JNIF01000003_gene1825	7.293e-123	402.0	COG0078@1|root,COG0078@2|Bacteria,3Y3WW@57723|Acidobacteria	57723|Acidobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_4062038_1	1232410.KI421413_gene878	1.758e-214	680.0	COG0433@1|root,COG0561@1|root,COG0433@2|Bacteria,COG0561@2|Bacteria,1P5B8@1224|Proteobacteria	1224|Proteobacteria	S	Haloacid dehalogenase domain protein hydrolase, type 3	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,DUF87,Hydrolase_3
TLS2_k127_4062038_6	234267.Acid_7445	2.093e-44	172.0	COG0589@1|root,COG0589@2|Bacteria,3Y5Y7@57723|Acidobacteria	57723|Acidobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_4063887_3	1463887.KL589966_gene2389	7.886e-25	105.0	COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_4063887_1	1267535.KB906767_gene2656	2.689e-80	271.0	COG1898@1|root,COG1898@2|Bacteria,3Y5V0@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
TLS2_k127_4063887_0	234267.Acid_6226	9.163e-121	391.0	COG1209@1|root,COG1209@2|Bacteria,3Y2ZJ@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_4063887_2	1173021.ALWA01000025_gene2542	2.855e-38	164.0	COG1361@1|root,COG1361@2|Bacteria,1G19J@1117|Cyanobacteria	1117|Cyanobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_4063971_0	1340493.JNIF01000004_gene454	5.44e-194	621.0	COG1249@1|root,COG1249@2|Bacteria	2|Bacteria	C	cell redox homeostasis	M1-534	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored,SLH
TLS2_k127_4063971_1	443598.AUFA01000022_gene3252	1.68e-84	288.0	COG2706@1|root,COG2706@2|Bacteria,1R9QR@1224|Proteobacteria,2U4RJ@28211|Alphaproteobacteria,3K346@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS2_k127_4065632_2	1223523.H340_23183	1.872e-72	248.0	COG0431@1|root,COG0431@2|Bacteria,2GNFR@201174|Actinobacteria	201174|Actinobacteria	K	NAD(P)H-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS2_k127_4065632_3	234267.Acid_5358	2.22e-58	209.0	COG2318@1|root,COG2318@2|Bacteria,3Y5DP@57723|Acidobacteria	57723|Acidobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_4065632_0	234267.Acid_7231	0.0	1182.0	COG3533@1|root,COG3533@2|Bacteria,3Y6B7@57723|Acidobacteria	57723|Acidobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
TLS2_k127_4065632_4	370438.PTH_0943	3.442e-15	86.0	COG3861@1|root,COG3861@2|Bacteria,1V5RZ@1239|Firmicutes,25E5M@186801|Clostridia	186801|Clostridia	S	Heat induced stress protein YflT	-	-	-	-	-	-	-	-	-	-	-	-	YflT
TLS2_k127_4065632_1	234267.Acid_4539	4.96e-234	735.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,3Y6VT@57723|Acidobacteria	57723|Acidobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
TLS2_k127_4070259_5	234267.Acid_7126	2.513e-70	243.0	COG0673@1|root,COG0673@2|Bacteria,3Y7D9@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4070259_4	234267.Acid_7125	2.917e-79	269.0	COG0662@1|root,COG0662@2|Bacteria,3Y6AM@57723|Acidobacteria	57723|Acidobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_4070259_1	1267535.KB906767_gene5172	4.945e-219	688.0	COG4225@1|root,COG4225@2|Bacteria,3Y6Y6@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyl Hydrolase Family 88	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
TLS2_k127_4070259_3	1173025.GEI7407_3200	1.535e-170	549.0	COG1231@1|root,COG1231@2|Bacteria,1G18A@1117|Cyanobacteria,1H6YY@1150|Oscillatoriales	1117|Cyanobacteria	E	Monoamine oxidase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS2_k127_4070259_2	1267535.KB906767_gene2136	2.016e-180	573.0	COG0673@1|root,COG0673@2|Bacteria,3Y78W@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_4070259_0	483219.LILAB_01975	0.0	1136.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42M33@68525|delta/epsilon subdivisions,2WJGS@28221|Deltaproteobacteria,2YU96@29|Myxococcales	28221|Deltaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS2_k127_4070259_6	1347086.CCBA010000012_gene2030	5.064e-05	49.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4070621_1	234267.Acid_6420	1.67e-56	203.0	2A6XZ@1|root,30VSX@2|Bacteria,3Y4RH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4070621_2	234267.Acid_2827	1.552e-26	114.0	COG1826@1|root,COG1826@2|Bacteria,3Y5TY@57723|Acidobacteria	57723|Acidobacteria	U	mttA/Hcf106 family	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS2_k127_4070621_0	1267535.KB906767_gene3324	3.489e-121	398.0	COG0805@1|root,COG0805@2|Bacteria,3Y3UC@57723|Acidobacteria,2JISU@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
TLS2_k127_4077510_1	472759.Nhal_3295	2.922e-85	295.0	COG1680@1|root,COG1680@2|Bacteria,1NPBV@1224|Proteobacteria,1SQWZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Domain of unknown function (DUF4185)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185
TLS2_k127_4077510_0	243090.RB7879	9.957e-102	347.0	COG3119@1|root,COG3119@2|Bacteria,2IYH5@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.4	ko:K01132	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00077,M00079	R07806	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
TLS2_k127_4077510_2	234267.Acid_1992	8.865e-24	102.0	COG1680@1|root,COG1680@2|Bacteria,3Y8A8@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_4120082_2	234267.Acid_0394	7.304e-145	475.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02481,ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_4120082_5	234267.Acid_0393	1.992e-38	150.0	COG1913@1|root,COG1913@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
TLS2_k127_4120082_1	234267.Acid_0392	8.049e-170	548.0	COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria	57723|Acidobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_4120082_3	234267.Acid_4996	3.286e-118	386.0	COG0726@1|root,COG0726@2|Bacteria,3Y51E@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_4120082_4	234267.Acid_2822	1.804e-57	225.0	28J3W@1|root,2Z900@2|Bacteria,3Y47Q@57723|Acidobacteria	57723|Acidobacteria	S	pfam nipsnap	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
TLS2_k127_4120082_0	234267.Acid_6969	1.421e-189	599.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TLS2_k127_4120082_6	234267.Acid_6968	5.17e-11	64.0	COG5012@1|root,COG5012@2|Bacteria,3Y88D@57723|Acidobacteria	57723|Acidobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
TLS2_k127_4121103_1	1492737.FEM08_05310	3.305e-115	381.0	COG2227@1|root,COG2227@2|Bacteria,4PK4H@976|Bacteroidetes,1ID51@117743|Flavobacteriia,2NXC0@237|Flavobacterium	976|Bacteroidetes	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS2_k127_4121103_0	713587.THITH_17365	1.734e-176	586.0	COG0574@1|root,COG3173@1|root,COG0574@2|Bacteria,COG3173@2|Bacteria,1Q33X@1224|Proteobacteria,1RNSN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GT	COG0574 Phosphoenolpyruvate synthase pyruvate phosphate dikinase	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016999,GO:0017000,GO:0017144,GO:0044237,GO:0044249	2.7.9.2	ko:K01007,ko:K21787	ko00333,ko00620,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00333,map00620,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00374,M00837,M00838	R00199,R11662,R11673	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
TLS2_k127_4121103_2	713587.THITH_17370	1.056e-24	106.0	COG0575@1|root,COG0575@2|Bacteria	2|Bacteria	I	Belongs to the CDS family	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41,2.7.7.67	ko:K00981,ko:K19664	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799,R08966	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1397	CTP_transf_1,CarS-like
TLS2_k127_4145299_7	234267.Acid_7561	3.328e-18	88.0	COG0525@1|root,COG0525@2|Bacteria,3Y2JY@57723|Acidobacteria	57723|Acidobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TLS2_k127_4145299_1	1340493.JNIF01000004_gene948	1.618e-108	359.0	COG0157@1|root,COG0157@2|Bacteria,3Y2H5@57723|Acidobacteria	57723|Acidobacteria	H	Belongs to the NadC ModD family	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
TLS2_k127_4145299_4	1267535.KB906767_gene4716	1.975e-66	233.0	COG0340@1|root,COG0340@2|Bacteria,3Y4PB@57723|Acidobacteria,2JJAU@204432|Acidobacteriia	204432|Acidobacteriia	H	Biotin/lipoate A/B protein ligase family	-	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
TLS2_k127_4145299_2	234267.Acid_7558	1.717e-104	349.0	COG1521@1|root,COG1521@2|Bacteria,3Y398@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
TLS2_k127_4145299_3	234267.Acid_7557	2.157e-73	256.0	COG3468@1|root,COG3468@2|Bacteria,3Y4NE@57723|Acidobacteria	57723|Acidobacteria	MU	outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4145299_6	234267.Acid_3837	1.235e-44	181.0	COG3485@1|root,COG4932@1|root,COG3485@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K14194	ko05150,map05150	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,DUF11,Gram_pos_anchor,SdrD_B
TLS2_k127_4145299_0	234267.Acid_6614	1.09e-113	377.0	2EZW8@1|root,33T0M@2|Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
TLS2_k127_4145299_5	452637.Oter_2179	3.086e-56	199.0	COG2303@1|root,COG2303@2|Bacteria,46V33@74201|Verrucomicrobia	74201|Verrucomicrobia	E	GMC oxidoreductase	betA	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_4148612_0	1340493.JNIF01000003_gene4144	8.425e-140	456.0	COG1629@1|root,COG4771@2|Bacteria,3Y3KA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_4148612_2	641491.DND132_1944	8.428e-57	208.0	COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,42MCJ@68525|delta/epsilon subdivisions,2WKQ4@28221|Deltaproteobacteria,2M94E@213115|Desulfovibrionales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_4148612_1	344747.PM8797T_25371	7.966e-58	215.0	COG0475@1|root,COG0475@2|Bacteria,2J51D@203682|Planctomycetes	203682|Planctomycetes	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
TLS2_k127_41488_0	314230.DSM3645_17550	1.085e-132	436.0	COG0058@1|root,COG0058@2|Bacteria,2IY0J@203682|Planctomycetes	203682|Planctomycetes	G	COG0058 Glucan phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
TLS2_k127_41488_1	1379270.AUXF01000007_gene1075	5.894e-11	65.0	COG0515@1|root,COG3170@1|root,COG0515@2|Bacteria,COG3170@2|Bacteria,1ZTGA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_4157134_0	1286106.MPL1_05374	1.441e-180	579.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,4601B@72273|Thiotrichales	72273|Thiotrichales	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_4170187_2	313596.RB2501_06305	2.231e-06	52.0	COG0671@1|root,COG0671@2|Bacteria,4NKIN@976|Bacteroidetes	976|Bacteroidetes	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS2_k127_4170187_0	1134474.O59_000531	8.248e-52	196.0	2A087@1|root,30NBF@2|Bacteria,1N3MQ@1224|Proteobacteria,1SA7F@1236|Gammaproteobacteria,1FGNP@10|Cellvibrio	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4170187_1	1121937.AUHJ01000002_gene3632	5.707e-09	57.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,1RPD0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_4179398_0	1340493.JNIF01000003_gene3639	0.0	1253.0	COG4775@1|root,COG4775@2|Bacteria,3Y2Q9@57723|Acidobacteria	57723|Acidobacteria	M	Surface antigen variable number	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TLS2_k127_4179398_2	234267.Acid_6469	6.766e-44	169.0	COG2825@1|root,COG2825@2|Bacteria,3Y56P@57723|Acidobacteria	57723|Acidobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
TLS2_k127_4179398_1	1267535.KB906767_gene4244	5.067e-71	249.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,BNR_4
TLS2_k127_419135_3	234267.Acid_2046	5.298e-55	200.0	COG0642@1|root,COG0745@1|root,COG1511@1|root,COG2770@1|root,COG3437@1|root,COG0745@2|Bacteria,COG1511@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,COG3437@2|Bacteria,3Y6RW@57723|Acidobacteria	57723|Acidobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg
TLS2_k127_419135_2	234267.Acid_2047	8.595e-123	406.0	COG3437@1|root,COG4251@1|root,COG3437@2|Bacteria,COG4251@2|Bacteria,3Y4QP@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
TLS2_k127_419135_0	1191523.MROS_1588	1.104e-171	549.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	fucP	-	-	ko:K02429	-	-	-	-	ko00000,ko02000	2.A.1.7	-	-	MFS_1
TLS2_k127_419135_1	234267.Acid_5992	3.792e-151	486.0	COG0842@1|root,COG0842@2|Bacteria,3Y73W@57723|Acidobacteria	57723|Acidobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_419135_4	234267.Acid_5991	1.552e-35	137.0	COG0842@1|root,COG0842@2|Bacteria,3Y4H7@57723|Acidobacteria	57723|Acidobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_419760_1	1194165.CAJF01000015_gene1446	1.314e-12	80.0	COG5512@1|root,COG5512@2|Bacteria,2HUUR@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
TLS2_k127_419760_0	1340493.JNIF01000004_gene554	8.817e-70	245.0	COG1052@1|root,COG1052@2|Bacteria,3Y2MD@57723|Acidobacteria	2|Bacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.26,1.1.1.399,1.1.1.95	ko:K00015,ko:K00058	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020	R00717,R01388,R01513	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_4202236_1	1340493.JNIF01000004_gene859	7.598e-113	375.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
TLS2_k127_4202236_3	1340493.JNIF01000003_gene4762	1.584e-80	277.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Calx-beta,DUF1080,F5_F8_type_C,PA14
TLS2_k127_4202236_0	483219.LILAB_20440	5.895e-157	523.0	2DTS5@1|root,33MFE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4202236_2	1038859.AXAU01000016_gene6832	2.301e-106	351.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2TUQ1@28211|Alphaproteobacteria,3JRVC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_4204664_8	1089439.KB902251_gene1515	2.418e-07	56.0	2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4204664_0	316067.Geob_3238	3.449e-273	858.0	COG3408@1|root,COG3408@2|Bacteria,1MW01@1224|Proteobacteria,42NSN@68525|delta/epsilon subdivisions,2WJF7@28221|Deltaproteobacteria,43TN0@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
TLS2_k127_4204664_1	1232410.KI421416_gene2671	1.684e-246	777.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,42MKI@68525|delta/epsilon subdivisions,2WM5H@28221|Deltaproteobacteria,43TX2@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Domain of unknown function (DUF3459)	treZ-2	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
TLS2_k127_4204664_6	269796.Rru_A2820	9.936e-21	96.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2JPID@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg
TLS2_k127_4204664_3	1340493.JNIF01000003_gene1861	6.819e-181	596.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,TonB_dep_Rec
TLS2_k127_4204664_2	1267535.KB906767_gene829	7.296e-226	719.0	COG0457@1|root,COG0457@2|Bacteria,3Y35N@57723|Acidobacteria,2JHIM@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
TLS2_k127_4204664_5	234267.Acid_1440	1.169e-68	244.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	6.5.1.3	ko:K14680	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos_2,RNA_lig_T4_1
TLS2_k127_4204664_7	1201293.AKXQ01000010_gene3278	2.698e-11	76.0	COG4775@1|root,COG4775@2|Bacteria,1RDM0@1224|Proteobacteria,1SK9K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
TLS2_k127_4204664_4	309807.SRU_0977	2.25e-80	290.0	2AB2F@1|root,310G6@2|Bacteria,4PEZP@976|Bacteroidetes,1FJWS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4220830_6	234267.Acid_4931	2.225e-41	158.0	2FIDY@1|root,34A64@2|Bacteria,3Y8PB@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4220830_1	1267535.KB906767_gene1044	8.069e-68	233.0	COG1327@1|root,COG1327@2|Bacteria,3Y4GA@57723|Acidobacteria	57723|Acidobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
TLS2_k127_4220830_2	1340493.JNIF01000003_gene1687	1.182e-66	240.0	COG0392@1|root,COG0392@2|Bacteria,3Y3SG@57723|Acidobacteria	57723|Acidobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS2_k127_4220830_0	1340493.JNIF01000003_gene1688	2.994e-84	286.0	COG1595@1|root,COG1595@2|Bacteria,3Y4HK@57723|Acidobacteria	57723|Acidobacteria	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4220830_4	1267535.KB906767_gene1042	1.365e-54	198.0	COG5662@1|root,COG5662@2|Bacteria,3Y4S0@57723|Acidobacteria	57723|Acidobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_4220830_3	234267.Acid_0791	9.841e-61	224.0	2DMGW@1|root,32REM@2|Bacteria,3Y4XX@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-B_box
TLS2_k127_4220830_8	1205753.A989_05838	8.627e-07	58.0	2ASNB@1|root,31I32@2|Bacteria,1QFS7@1224|Proteobacteria,1TD1Z@1236|Gammaproteobacteria,1X8TG@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4220830_5	1267535.KB906767_gene1039	7.745e-53	203.0	COG3595@1|root,COG3595@2|Bacteria,3Y3K3@57723|Acidobacteria,2JHKF@204432|Acidobacteriia	204432|Acidobacteriia	C	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_4224836_1	1340493.JNIF01000004_gene871	8.597e-140	452.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C,TAT_signal
TLS2_k127_4224836_2	234267.Acid_4488	1.744e-44	175.0	29QWH@1|root,30BWY@2|Bacteria,3Y4SG@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4224836_0	234267.Acid_4491	3.331e-228	719.0	COG0653@1|root,COG0653@2|Bacteria,3Y34P@57723|Acidobacteria	57723|Acidobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TLS2_k127_4225548_0	1340493.JNIF01000003_gene1299	3.84e-125	409.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,EcsC
TLS2_k127_4225548_1	483219.LILAB_32555	2.212e-12	78.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,43AGY@68525|delta/epsilon subdivisions,2X5WX@28221|Deltaproteobacteria,2YWWR@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,zf-HC2
TLS2_k127_4225548_2	1267535.KB906767_gene3269	1.425e-09	68.0	2E1AY@1|root,32WQW@2|Bacteria,3Y8WG@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4227609_0	234267.Acid_1761	9.169e-143	463.0	COG1355@1|root,COG1355@2|Bacteria,3Y5Z0@57723|Acidobacteria	57723|Acidobacteria	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
TLS2_k127_4227609_1	1267533.KB906733_gene3362	4.528e-124	419.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS2_k127_4227609_3	234267.Acid_6963	1.909e-43	164.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
TLS2_k127_4227609_2	1340493.JNIF01000003_gene1819	4.277e-88	297.0	COG2911@1|root,COG4775@1|root,COG2911@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K07277,ko:K09800	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	AsmA_2,Bac_surface_Ag,DUF748,POTRA,TamB
TLS2_k127_4232545_1	1267535.KB906767_gene5367	1.083e-15	82.0	COG0457@1|root,COG0457@2|Bacteria	1267535.KB906767_gene5367|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4232545_2	1183438.GKIL_1183	1.919e-15	88.0	2EMHK@1|root,33F68@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4232545_0	1267535.KB906767_gene3483	8.438e-318	1007.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_4234815_1	1266914.ATUK01000013_gene1801	3.907e-75	265.0	COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,1RN0Y@1236|Gammaproteobacteria,1X0KZ@135613|Chromatiales	135613|Chromatiales	N	Bacterial flagellin C-terminal helical region	-	-	-	-	-	-	-	-	-	-	-	-	Flagellin_C,Flagellin_N
TLS2_k127_4234815_0	323261.Noc_2368	9.044e-96	327.0	COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,1RPNR@1236|Gammaproteobacteria,1WX4A@135613|Chromatiales	135613|Chromatiales	N	TIGRFAM Flagellar hook-associated protein 3	-	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
TLS2_k127_4251183_2	234267.Acid_0669	5.151e-39	150.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS2_k127_4251183_1	221288.JH992901_gene3734	8.688e-108	379.0	COG1404@1|root,COG1404@2|Bacteria,1GKQA@1117|Cyanobacteria,1JMJR@1189|Stigonemataceae	1117|Cyanobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS2_k127_4251183_3	1288298.rosmuc_01546	3.25e-08	59.0	2F5RW@1|root,33YAS@2|Bacteria,1NCJW@1224|Proteobacteria,2UJ78@28211|Alphaproteobacteria,46RUM@74030|Roseovarius	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4251183_0	1202768.JROF01000001_gene1580	1.943e-185	591.0	COG0277@1|root,arCOG00337@2157|Archaea,2XT8F@28890|Euryarchaeota,23SGR@183963|Halobacteria	183963|Halobacteria	C	COG0277 FAD FMN-containing dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_425446_1	1340493.JNIF01000004_gene386	3.952e-108	357.0	COG0179@1|root,COG0179@2|Bacteria,3Y30T@57723|Acidobacteria	57723|Acidobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
TLS2_k127_425446_0	234267.Acid_4473	1.2e-144	465.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	ko:K15045	ko05164,map05164	-	-	-	ko00000,ko00001	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
TLS2_k127_425446_2	234267.Acid_4451	1.832e-97	336.0	COG0673@1|root,COG0673@2|Bacteria,3Y71T@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_425446_3	344747.PM8797T_12623	7.153e-92	310.0	COG0657@1|root,COG0657@2|Bacteria,2IXCK@203682|Planctomycetes	203682|Planctomycetes	I	COG0657 Esterase lipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS2_k127_425446_4	243090.RB5295	5.864e-18	91.0	COG3119@1|root,COG3119@2|Bacteria,2IXH3@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_425446_5	1122137.AQXF01000005_gene1090	1.528e-07	55.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2TRNV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
TLS2_k127_4257952_0	234267.Acid_7240	3.712e-115	382.0	COG0542@1|root,COG2204@1|root,COG0542@2|Bacteria,COG2204@2|Bacteria,3Y6T8@57723|Acidobacteria	57723|Acidobacteria	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small,Response_reg
TLS2_k127_4257952_4	1267535.KB906767_gene689	4.182e-37	140.0	COG0361@1|root,COG0361@2|Bacteria,3Y8IP@57723|Acidobacteria	57723|Acidobacteria	J	Translation initiation factor 1A / IF-1	-	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
TLS2_k127_4257952_3	1267535.KB906767_gene3892	8.666e-52	186.0	COG0071@1|root,COG0071@2|Bacteria,3Y4TM@57723|Acidobacteria,2JJFI@204432|Acidobacteriia	204432|Acidobacteriia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS2_k127_4257952_1	1267535.KB906767_gene2673	3.23e-100	334.0	COG0501@1|root,COG0501@2|Bacteria,3Y3EZ@57723|Acidobacteria,2JIIZ@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS2_k127_4257952_2	234267.Acid_2335	2.569e-98	329.0	COG1092@1|root,COG1092@2|Bacteria,3Y2PV@57723|Acidobacteria	57723|Acidobacteria	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TLS2_k127_4270322_6	204669.Acid345_0503	4.961e-19	87.0	COG2191@1|root,COG2191@2|Bacteria,3Y43J@57723|Acidobacteria,2JHT2@204432|Acidobacteriia	204432|Acidobacteriia	C	FmdE, Molybdenum formylmethanofuran dehydrogenase operon	-	-	1.2.7.12	ko:K11261	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	FmdE,zf-dskA_traR
TLS2_k127_4270322_3	1340493.JNIF01000003_gene3601	2.982e-112	381.0	COG3842@1|root,COG3842@2|Bacteria,3Y4VR@57723|Acidobacteria	57723|Acidobacteria	E	PFAM ABC transporter	-	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran
TLS2_k127_4270322_5	1267535.KB906767_gene4846	1.856e-81	280.0	COG4149@1|root,COG4149@2|Bacteria,3Y4EA@57723|Acidobacteria,2JJ3Z@204432|Acidobacteriia	204432|Acidobacteriia	P	Molybdate ABC transporter	-	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
TLS2_k127_4270322_2	247490.KSU1_C1031	4.341e-133	436.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2IZRY@203682|Planctomycetes	203682|Planctomycetes	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
TLS2_k127_4270322_4	1340493.JNIF01000003_gene3599	1.782e-108	357.0	COG3828@1|root,COG3828@2|Bacteria,3Y2VP@57723|Acidobacteria	57723|Acidobacteria	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
TLS2_k127_4270322_0	234267.Acid_3249	2.14e-206	650.0	COG0215@1|root,COG0215@2|Bacteria,3Y2PW@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
TLS2_k127_4270322_1	234267.Acid_3250	1.835e-164	525.0	COG0626@1|root,COG0626@2|Bacteria	2|Bacteria	E	cystathionine gamma-synthase activity	megL	-	2.5.1.48,2.5.1.49,4.4.1.11,4.4.1.8	ko:K01739,ko:K01740,ko:K01760,ko:K01761,ko:K10764	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01287,R01288,R02408,R02508,R03217,R03260,R04770,R04859,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02821,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS2_k127_4276150_5	234267.Acid_1435	1.391e-07	55.0	COG5621@1|root,COG5621@2|Bacteria	2|Bacteria	S	spheroidene biosynthetic process	attH	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
TLS2_k127_4276150_1	1340493.JNIF01000003_gene2715	4.426e-224	720.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	salY	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_4276150_2	443218.AS9A_0370	1.711e-60	215.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,233TP@1762|Mycobacteriaceae	201174|Actinobacteria	V	ABC transporter	lolD	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4276150_4	709991.Odosp_1620	6.113e-12	77.0	COG1680@1|root,COG1680@2|Bacteria,4NEVS@976|Bacteroidetes,2FQJ2@200643|Bacteroidia,22WP5@171551|Porphyromonadaceae	976|Bacteroidetes	V	Beta-lactamase	nylB	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_4276150_0	1267535.KB906767_gene4296	3.542e-312	968.0	COG0129@1|root,COG0129@2|Bacteria,3Y3B1@57723|Acidobacteria	57723|Acidobacteria	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82	ko:K22396	ko00040,map00040	-	R02429	RC00543	ko00000,ko00001,ko01000	-	-	-	ILVD_EDD
TLS2_k127_4276150_3	1198114.AciX9_3315	9.735e-27	117.0	COG0577@1|root,COG0577@2|Bacteria,3Y44G@57723|Acidobacteria,2JHKI@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_4289118_1	1267533.KB906736_gene1283	7.781e-69	238.0	COG0252@1|root,COG0252@2|Bacteria,3Y8XT@57723|Acidobacteria	57723|Acidobacteria	EJ	Asparaginase	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase
TLS2_k127_4289118_2	398767.Glov_1014	1.362e-35	149.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,42MDZ@68525|delta/epsilon subdivisions,2WJ9Y@28221|Deltaproteobacteria,43TUI@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
TLS2_k127_4289118_0	391038.Bphy_7430	2.481e-159	518.0	COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,2VJQH@28216|Betaproteobacteria,1K4UF@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Integrase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_4291860_1	266779.Meso_2424	5.561e-97	324.0	COG4294@1|root,COG4294@2|Bacteria,1R4A5@1224|Proteobacteria,2TU71@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	UV-endonuclease UvdE	-	-	-	ko:K13281	-	-	-	-	ko00000,ko01000	-	-	-	UvdE
TLS2_k127_4291860_4	448385.sce3271	1.219e-49	184.0	COG0406@1|root,COG0406@2|Bacteria,1QNKS@1224|Proteobacteria,434AH@68525|delta/epsilon subdivisions,2WYK2@28221|Deltaproteobacteria,2Z1NH@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TLS2_k127_4291860_3	1267535.KB906767_gene995	3.672e-87	299.0	COG0510@1|root,COG0510@2|Bacteria	2|Bacteria	M	ethanolamine kinase activity	-	-	2.7.1.89	ko:K07251	ko00730,ko01100,map00730,map01100	-	R02134	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	APH,Choline_kinase
TLS2_k127_4291860_0	234267.Acid_2580	5.486e-235	736.0	COG3119@1|root,COG3119@2|Bacteria,3Y6SJ@57723|Acidobacteria	57723|Acidobacteria	P	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
TLS2_k127_4291860_2	234267.Acid_7056	9.572e-91	304.0	COG0846@1|root,COG0846@2|Bacteria,3Y4T9@57723|Acidobacteria	57723|Acidobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
TLS2_k127_4291860_5	983917.RGE_23380	6.05e-38	158.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_10,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
TLS2_k127_4295731_3	1487953.JMKF01000005_gene596	0.0001485	45.0	COG0438@1|root,COG0438@2|Bacteria,1G4KT@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_4295731_1	1142394.PSMK_19720	7.1e-57	212.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_4295731_0	1173028.ANKO01000030_gene3279	1.116e-73	259.0	COG1216@1|root,COG1216@2|Bacteria,1G2MT@1117|Cyanobacteria,1H8YG@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
TLS2_k127_4295731_2	794903.OPIT5_27565	6.315e-20	94.0	2DHIW@1|root,2ZZZR@2|Bacteria,46WA6@74201|Verrucomicrobia	794903.OPIT5_27565|-	S	Heparinase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4299729_3	1340493.JNIF01000004_gene279	1.152e-175	574.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,TIR_2,WD40
TLS2_k127_4299729_4	1340493.JNIF01000004_gene280	6.539e-157	507.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC4_WD40,PD40,PSCyt1,WD40
TLS2_k127_4299729_6	861299.J421_1942	1.147e-35	138.0	COG1937@1|root,COG1937@2|Bacteria,1ZTZF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
TLS2_k127_4299729_5	234267.Acid_4906	5.528e-139	457.0	COG3667@1|root,COG3667@2|Bacteria,3Y3FP@57723|Acidobacteria	57723|Acidobacteria	P	copper resistance	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4299729_7	387631.Asulf_00300	1.79e-15	76.0	COG3350@1|root,arCOG04507@2157|Archaea	2157|Archaea	P	PFAM YHS domain	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
TLS2_k127_4299729_0	1242864.D187_000364	0.0	1032.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YTUI@29|Myxococcales	28221|Deltaproteobacteria	P	copper-translocating P-type ATPase	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
TLS2_k127_4299729_2	504472.Slin_4601	8.422e-216	674.0	COG1063@1|root,COG1063@2|Bacteria,4NIU2@976|Bacteroidetes,47MH0@768503|Cytophagia	976|Bacteroidetes	E	Alcohol dehydrogenase GroES-like domain	-	-	1.2.1.46	ko:K00148	ko00625,ko00680,ko01100,ko01120,ko01200,map00625,map00680,map01100,map01120,map01200	-	R00604	RC00188	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_4299729_1	266117.Rxyl_0146	4.908e-227	714.0	COG0243@1|root,COG0243@2|Bacteria,2GJWZ@201174|Actinobacteria,4CQ1R@84995|Rubrobacteria	84995|Rubrobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
TLS2_k127_4302498_0	886293.Sinac_1739	5.825e-156	515.0	COG2010@1|root,COG2010@2|Bacteria,2IXBU@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_4302498_1	497964.CfE428DRAFT_6606	8.053e-83	278.0	COG1368@1|root,COG1368@2|Bacteria	2|Bacteria	M	sulfuric ester hydrolase activity	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	PMT_2,Sulfatase,Wzy_C
TLS2_k127_4305196_0	1267534.KB906755_gene4473	1.753e-76	276.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria	2|Bacteria	K	Transcriptional regulator	hilA	-	-	ko:K22486	-	-	-	-	ko00000,ko03000	-	-	-	PD40,Trans_reg_C,WD40
TLS2_k127_4305196_1	1267535.KB906767_gene985	7.869e-66	231.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	GO:0003674,GO:0003824,GO:0004747,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019303,GO:0019321,GO:0019323,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.15,2.7.1.4	ko:K00847,ko:K00852	ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100	-	R00760,R00867,R01051,R02750,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iE2348C_1286.E2348C_4062,iEcDH1_1363.EcDH1_4215	PfkB
TLS2_k127_4308100_11	234267.Acid_4203	2.457e-25	106.0	COG0509@1|root,COG0509@2|Bacteria,3Y7RS@57723|Acidobacteria	57723|Acidobacteria	E	Glycine cleavage H-protein	-	-	-	-	-	-	-	-	-	-	-	-	GCV_H
TLS2_k127_4308100_5	234267.Acid_4204	7.176e-114	373.0	COG0437@1|root,COG0437@2|Bacteria,3Y5RE@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
TLS2_k127_4308100_3	234267.Acid_4205	8.932e-167	534.0	COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria	57723|Acidobacteria	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
TLS2_k127_4308100_2	234267.Acid_4206	1.182e-180	580.0	COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria	57723|Acidobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_4308100_1	234267.Acid_4207	2.504e-209	662.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria	57723|Acidobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_4308100_8	234267.Acid_4208	2.588e-51	187.0	COG1913@1|root,COG1913@2|Bacteria,3Y880@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M54	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
TLS2_k127_4308100_6	234267.Acid_3571	6.108e-75	260.0	COG0558@1|root,COG0558@2|Bacteria,3Y4PW@57723|Acidobacteria	57723|Acidobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
TLS2_k127_4308100_13	204669.Acid345_4178	1.619e-14	80.0	COG2246@1|root,COG2246@2|Bacteria,3Y5HC@57723|Acidobacteria,2JJXS@204432|Acidobacteriia	204432|Acidobacteriia	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
TLS2_k127_4308100_7	234267.Acid_1779	8.24e-73	264.0	COG1304@1|root,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	-	-	1.1.3.15,1.1.3.46	ko:K00104,ko:K16422	ko00261,ko00630,ko01055,ko01100,ko01110,ko01120,ko01130,map00261,map00630,map01055,map01100,map01110,map01120,map01130	-	R00475,R06633	RC00042,RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
TLS2_k127_4308100_14	1232410.KI421412_gene294	9.441e-08	61.0	COG3005@1|root,COG3005@2|Bacteria,1QYGG@1224|Proteobacteria,42NFU@68525|delta/epsilon subdivisions,2WKHN@28221|Deltaproteobacteria,43UCU@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
TLS2_k127_4308100_10	1403313.AXBR01000017_gene3750	9.038e-26	119.0	COG0346@1|root,COG0346@2|Bacteria,1V5GM@1239|Firmicutes,4HH66@91061|Bacilli,1ZD3V@1386|Bacillus	91061|Bacilli	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
TLS2_k127_4308100_0	760192.Halhy_3819	0.0	1123.0	COG0308@1|root,COG0842@1|root,COG1277@1|root,COG0308@2|Bacteria,COG0842@2|Bacteria,COG1277@2|Bacteria,4NF3R@976|Bacteroidetes,1IPQP@117747|Sphingobacteriia	976|Bacteroidetes	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
TLS2_k127_4308100_4	760192.Halhy_3820	1.392e-133	435.0	COG1131@1|root,COG1131@2|Bacteria,4NFWM@976|Bacteroidetes,1IQUT@117747|Sphingobacteriia	976|Bacteroidetes	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_4317940_10	1267535.KB906767_gene216	2.677e-73	259.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS2_k127_4317940_13	234267.Acid_1703	9.789e-31	126.0	2DMJE@1|root,32RYR@2|Bacteria,3Y4XN@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4112
TLS2_k127_4317940_16	706587.Desti_1948	4.836e-17	85.0	COG0784@1|root,COG2198@1|root,COG2202@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BU6@68525|delta/epsilon subdivisions,2X756@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_8,PAS_9,PocR,Response_reg
TLS2_k127_4317940_1	1340493.JNIF01000003_gene1853	9.118e-163	520.0	COG0343@1|root,COG0343@2|Bacteria,3Y3CP@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
TLS2_k127_4317940_14	234267.Acid_1277	3.249e-28	116.0	COG1862@1|root,COG1862@2|Bacteria,3Y5GK@57723|Acidobacteria	57723|Acidobacteria	U	Preprotein translocase, YajC	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TLS2_k127_4317940_0	1340493.JNIF01000003_gene1851	4.202e-207	657.0	COG0342@1|root,COG0342@2|Bacteria,3Y37S@57723|Acidobacteria	57723|Acidobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_4317940_3	234267.Acid_1279	9.788e-142	460.0	COG0341@1|root,COG0341@2|Bacteria,3Y2ZT@57723|Acidobacteria	57723|Acidobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_4317940_6	234267.Acid_1280	1.191e-101	336.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TLS2_k127_4317940_5	234267.Acid_1281	2.276e-115	376.0	COG0811@1|root,COG0811@2|Bacteria,3Y2M4@57723|Acidobacteria	57723|Acidobacteria	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
TLS2_k127_4317940_11	234267.Acid_1282	4.608e-54	196.0	COG0848@1|root,COG0848@2|Bacteria,3Y4TE@57723|Acidobacteria	57723|Acidobacteria	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS2_k127_4317940_15	204669.Acid345_4001	5.336e-25	109.0	COG0848@1|root,COG0848@2|Bacteria,3Y5AP@57723|Acidobacteria,2JJQV@204432|Acidobacteriia	204432|Acidobacteriia	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS2_k127_4317940_8	1340493.JNIF01000003_gene1845	1.046e-90	306.0	COG0457@1|root,COG0457@2|Bacteria,3Y3N5@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
TLS2_k127_4317940_7	204669.Acid345_3481	2.938e-94	318.0	COG1291@1|root,COG1291@2|Bacteria,3Y3Y8@57723|Acidobacteria,2JI9S@204432|Acidobacteriia	204432|Acidobacteriia	N	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
TLS2_k127_4317940_9	234267.Acid_5889	9.931e-85	288.0	COG1360@1|root,COG1360@2|Bacteria,3Y47G@57723|Acidobacteria	57723|Acidobacteria	N	Membrane MotB of proton-channel complex MotA/MotB	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
TLS2_k127_4317940_2	234267.Acid_6092	1.012e-153	507.0	COG1574@1|root,COG1574@2|Bacteria,3Y7EK@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_4317940_12	234267.Acid_6093	9.327e-33	146.0	COG1574@1|root,COG1574@2|Bacteria	2|Bacteria	G	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_4317940_4	1340493.JNIF01000003_gene2268	3.049e-131	425.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4325243_0	359.CN09_03510	3.967e-183	580.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria,4BC7V@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,rve,rve_3
TLS2_k127_4325243_1	909663.KI867150_gene2875	1.22e-11	66.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,42Q95@68525|delta/epsilon subdivisions,2WKM2@28221|Deltaproteobacteria,2MS1I@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_5,Phage_integrase
TLS2_k127_4330650_0	278963.ATWD01000002_gene738	1.538e-117	401.0	COG1629@1|root,COG4771@2|Bacteria,3Y6GR@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_4330650_1	1499967.BAYZ01000194_gene3127	9.516e-69	241.0	COG1994@1|root,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	ywhC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
TLS2_k127_4331040_1	221288.JH992901_gene4597	1.327e-109	359.0	COG0667@1|root,COG0667@2|Bacteria,1G3RI@1117|Cyanobacteria,1JKCE@1189|Stigonemataceae	1117|Cyanobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_4331040_0	1340493.JNIF01000003_gene4293	1.806e-185	619.0	COG1629@1|root,COG4771@2|Bacteria,3Y2ZK@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_4331040_2	46429.BV95_03016	2.039e-35	139.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,2K2UP@204457|Sphingomonadales	204457|Sphingomonadales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,Response_reg,TPR_12
TLS2_k127_4339068_0	1144275.COCOR_01604	1.855e-57	213.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria,2YXK2@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_4339068_1	1410620.SHLA_2c002430	7.297e-33	130.0	COG1149@1|root,COG1149@2|Bacteria,1QTYV@1224|Proteobacteria,2TTH3@28211|Alphaproteobacteria,4BDG7@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	TIGRFAM CitB domain protein	tcuB	-	-	ko:K13795	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_4339688_0	1255043.TVNIR_3678	5.449e-24	105.0	COG3668@1|root,COG3668@2|Bacteria,1NAKC@1224|Proteobacteria,1SIHI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Plasmid stabilization protein ParE	-	-	-	ko:K19092	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
TLS2_k127_4339688_1	443598.AUFA01000027_gene1917	1.871e-14	77.0	COG3609@1|root,COG3609@2|Bacteria,1NA19@1224|Proteobacteria,2U96N@28211|Alphaproteobacteria,3JZGU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH	-	-	-	ko:K07746	-	-	-	-	ko00000,ko02048	-	-	-	ParD_antitoxin
TLS2_k127_4339688_2	1382359.JIAL01000001_gene60	5.012e-08	58.0	COG4584@1|root,COG4584@2|Bacteria,3Y7RI@57723|Acidobacteria	57723|Acidobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
TLS2_k127_4343917_6	1123288.SOV_3c05310	6.422e-09	61.0	COG2199@1|root,COG3706@2|Bacteria,1TQMM@1239|Firmicutes,4H8BM@909932|Negativicutes	909932|Negativicutes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
TLS2_k127_4343917_1	502025.Hoch_2041	1.091e-103	366.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_4343917_0	234267.Acid_4298	2.377e-246	772.0	COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,3Y3DA@57723|Acidobacteria	57723|Acidobacteria	J	Ribosomal protein S1	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
TLS2_k127_4343917_3	234267.Acid_4299	3.255e-45	166.0	COG0776@1|root,COG0776@2|Bacteria,3Y56V@57723|Acidobacteria	57723|Acidobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_4343917_2	234267.Acid_4300	1.141e-57	205.0	COG0537@1|root,COG0537@2|Bacteria,3Y4CN@57723|Acidobacteria	57723|Acidobacteria	FG	PFAM Histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
TLS2_k127_4343917_5	1284352.AOIG01000007_gene2080	1.461e-09	67.0	COG3861@1|root,COG3861@2|Bacteria,1V5RZ@1239|Firmicutes,4HHAU@91061|Bacilli,26SHD@186822|Paenibacillaceae	91061|Bacilli	S	Heat induced stress protein YflT	-	-	-	-	-	-	-	-	-	-	-	-	YflT
TLS2_k127_4343917_4	1079986.JH164846_gene2033	1.891e-25	109.0	COG2764@1|root,COG2764@2|Bacteria,2IG41@201174|Actinobacteria	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_4348986_3	1122604.JONR01000047_gene2049	5.502e-32	125.0	COG1257@1|root,COG1257@2|Bacteria,1Q6M1@1224|Proteobacteria,1RPEP@1236|Gammaproteobacteria,1X2Y1@135614|Xanthomonadales	135614|Xanthomonadales	I	Hydroxymethylglutaryl-coenzyme A reductase	-	-	-	-	-	-	-	-	-	-	-	-	HMG-CoA_red
TLS2_k127_4348986_4	234267.Acid_5724	4.088e-18	90.0	299CX@1|root,2ZWFU@2|Bacteria,3Y96U@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4348986_1	1267535.KB906767_gene3449	1.081e-148	477.0	COG1494@1|root,COG1494@2|Bacteria,3Y2XJ@57723|Acidobacteria,2JKWZ@204432|Acidobacteriia	204432|Acidobacteriia	G	Bacterial fructose-1,6-bisphosphatase, glpX-encoded	-	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
TLS2_k127_4348986_0	234267.Acid_5704	2.733e-227	715.0	COG0119@1|root,COG0119@2|Bacteria,3Y2WT@57723|Acidobacteria	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS10690,iYO844.BSU28280	HMGL-like,LeuA_dimer
TLS2_k127_4348986_2	661478.OP10G_4632	5.772e-54	206.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
TLS2_k127_4356604_1	671143.DAMO_1978	3.881e-34	134.0	COG1321@1|root,COG1321@2|Bacteria	2|Bacteria	K	iron dependent repressor	ideR	-	3.4.21.88	ko:K01356,ko:K03709	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03000,ko03400	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA,LexA_DNA_bind
TLS2_k127_4356604_0	452637.Oter_2291	3.188e-55	216.0	COG4688@1|root,COG4688@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4356604_2	910964.GEAM_3262	2.51e-31	138.0	COG0582@1|root,COG0582@2|Bacteria,1R4US@1224|Proteobacteria,1RPWW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_4360108_1	1348908.KI518629_gene363	2.234e-31	139.0	COG1680@1|root,COG1680@2|Bacteria,1UZZ5@1239|Firmicutes,4HA1I@91061|Bacilli,1ZBMQ@1386|Bacillus	91061|Bacilli	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
TLS2_k127_4360108_0	1340493.JNIF01000004_gene757	2.803e-40	164.0	COG5002@1|root,COG5002@2|Bacteria,3Y9FP@57723|Acidobacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,MASE1,MHYT,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg,SBP_bac_3
TLS2_k127_4360133_3	1340493.JNIF01000003_gene4181	2.29e-05	48.0	COG1879@1|root,COG1879@2|Bacteria,3Y872@57723|Acidobacteria	57723|Acidobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TLS2_k127_4360133_0	234267.Acid_2132	7.5e-107	352.0	COG1028@1|root,COG1028@2|Bacteria,3Y7BE@57723|Acidobacteria	57723|Acidobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_4360133_2	1380393.JHVP01000002_gene1722	6.083e-08	61.0	COG3428@1|root,COG3428@2|Bacteria,2GK6Y@201174|Actinobacteria,4EVYI@85013|Frankiales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
TLS2_k127_4360133_1	234267.Acid_2134	1.773e-75	267.0	2AC2T@1|root,311KW@2|Bacteria,3Y4QM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4361635_1	234267.Acid_4203	4.604e-59	211.0	COG0509@1|root,COG0509@2|Bacteria,3Y7RS@57723|Acidobacteria	57723|Acidobacteria	E	Glycine cleavage H-protein	-	-	-	-	-	-	-	-	-	-	-	-	GCV_H
TLS2_k127_4361635_0	234267.Acid_7890	5.922e-83	283.0	COG0134@1|root,COG0134@2|Bacteria,3Y3TH@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
TLS2_k127_4361635_2	234267.Acid_7889	1.302e-51	189.0	COG0135@1|root,COG0135@2|Bacteria,3Y50K@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
TLS2_k127_4365187_0	1267535.KB906767_gene3394	2.686e-114	374.0	COG0129@1|root,COG0129@2|Bacteria,3Y372@57723|Acidobacteria,2JIK1@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the IlvD Edd family	-	-	-	-	-	-	-	-	-	-	-	-	ILVD_EDD
TLS2_k127_4365187_5	234267.Acid_2045	3.966e-30	124.0	COG0745@1|root,COG0745@2|Bacteria	234267.Acid_2045|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4365187_1	234267.Acid_7221	1.014e-107	364.0	COG2271@1|root,COG2271@2|Bacteria,3Y2VG@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
TLS2_k127_4365187_3	1267535.KB906767_gene975	1.251e-87	296.0	COG0101@1|root,COG0101@2|Bacteria,3Y2MS@57723|Acidobacteria,2JIWS@204432|Acidobacteriia	204432|Acidobacteriia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
TLS2_k127_4365187_4	1267535.KB906767_gene974	3.01e-70	244.0	COG0461@1|root,COG0461@2|Bacteria	2|Bacteria	F	orotate phosphoribosyltransferase activity	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
TLS2_k127_4365187_2	234267.Acid_1848	4.58e-90	302.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4367465_1	1340493.JNIF01000003_gene3965	1.885e-163	525.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_4367465_8	706587.Desti_0963	1.071e-11	73.0	COG3861@1|root,COG3861@2|Bacteria,1RD6Y@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	PRC
TLS2_k127_4367465_0	1121441.AUCX01000006_gene992	3.285e-168	538.0	COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,42MXC@68525|delta/epsilon subdivisions,2WJJF@28221|Deltaproteobacteria,2MABI@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Oxidoreductase FAD-binding domain	nqrF	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
TLS2_k127_4367465_4	1323663.AROI01000009_gene3603	5.893e-76	259.0	COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria,1RMWV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
TLS2_k127_4367465_6	376733.IT41_02490	5.345e-58	211.0	COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,2U0DD@28211|Alphaproteobacteria,2PY52@265|Paracoccus	28211|Alphaproteobacteria	C	Rnf-Nqr subunit, membrane protein	nqrD	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
TLS2_k127_4367465_7	1117647.M5M_01225	9.577e-47	178.0	COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria,1J5HE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
TLS2_k127_4367465_3	1304888.ATWF01000001_gene1242	1.145e-84	294.0	COG4658@1|root,COG4658@2|Bacteria	2|Bacteria	C	electron transport chain	nqrB	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
TLS2_k127_4367465_2	1005058.UMN179_01112	9.347e-125	414.0	COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,1Y79N@135625|Pasteurellales	135625|Pasteurellales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrA	-	1.6.5.8	ko:K00346	-	-	-	-	ko00000,ko01000	-	-	-	NQRA,NQRA_SLBB
TLS2_k127_4367465_5	323261.Noc_2727	2.228e-67	242.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1WWAK@135613|Chromatiales	135613|Chromatiales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
TLS2_k127_4371506_1	1479237.JMLY01000001_gene2634	6.719e-103	342.0	COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,1T1IP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	synthase	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
TLS2_k127_4371506_5	1172185.KB911510_gene1329	1.148e-05	53.0	COG0296@1|root,COG0296@2|Bacteria,2GMIS@201174|Actinobacteria,4FVQH@85025|Nocardiaceae	201174|Actinobacteria	G	4-alpha-D-((1- 4)-alpha-D-glucano)trehalose trehalohydrolase	treZ	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0033942,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0071704,GO:1901575,GO:1901576	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
TLS2_k127_4371506_3	1279019.ARQK01000061_gene1757	2.091e-44	165.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1RP2N@1236|Gammaproteobacteria,1WWIM@135613|Chromatiales	135613|Chromatiales	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	-	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
TLS2_k127_4371506_4	1158165.KB898876_gene1352	1.682e-31	123.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1RP2N@1236|Gammaproteobacteria,1WWIM@135613|Chromatiales	135613|Chromatiales	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	-	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
TLS2_k127_4371506_0	1382359.JIAL01000001_gene2951	1.679e-120	396.0	COG0296@1|root,COG0296@2|Bacteria,3Y33J@57723|Acidobacteria,2JHJV@204432|Acidobacteriia	204432|Acidobacteriia	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	-	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
TLS2_k127_4371506_2	1267535.KB906767_gene4703	2.07e-45	172.0	COG1640@1|root,COG1640@2|Bacteria	2|Bacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.18,2.4.1.25,3.2.1.196,5.4.99.15	ko:K00700,ko:K00705,ko:K02438,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R02110,R02111,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13,GH77	iJN678.malQ	Alpha-amylase,Glyco_hydro_77
TLS2_k127_4371859_4	1430440.MGMSRv2_1358	8.195e-66	235.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2TSGV@28211|Alphaproteobacteria,2JRJR@204441|Rhodospirillales	204441|Rhodospirillales	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
TLS2_k127_4371859_0	1430440.MGMSRv2_1359	1.117e-126	434.0	COG0643@1|root,COG0745@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria,2JRJI@204441|Rhodospirillales	204441|Rhodospirillales	T	Two component signalling adaptor domain	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,HATPase_c,Hpt,Response_reg
TLS2_k127_4371859_1	1336243.JAEA01000001_gene1997	5.506e-117	397.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,1JSPG@119045|Methylobacteriaceae	28211|Alphaproteobacteria	NT	PFAM histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
TLS2_k127_4371859_6	262543.Exig_0985	5.96e-06	55.0	COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1TRJU@1239|Firmicutes,4HCPT@91061|Bacilli	91061|Bacilli	T	chemotaxis protein CheV	cheV	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0044424,GO:0044444,GO:0044464,GO:0050896	-	ko:K03408,ko:K03415	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	CheW,Response_reg
TLS2_k127_4371859_2	1244869.H261_13753	1.589e-112	379.0	COG1352@1|root,COG1352@2|Bacteria,1R6N1@1224|Proteobacteria,2U0BX@28211|Alphaproteobacteria,2JPBB@204441|Rhodospirillales	204441|Rhodospirillales	NT	chemotaxis protein methyltransferase	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
TLS2_k127_4371859_5	420324.KI912090_gene7103	1.966e-22	103.0	COG0835@1|root,COG0835@2|Bacteria,1N7QA@1224|Proteobacteria,2UF8V@28211|Alphaproteobacteria,1JYXM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
TLS2_k127_4371859_3	1267535.KB906767_gene569	1.822e-106	359.0	COG3829@1|root,COG4251@1|root,COG3829@2|Bacteria,COG4251@2|Bacteria,3Y99J@57723|Acidobacteria,2JKK0@204432|Acidobacteriia	204432|Acidobacteriia	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
TLS2_k127_4376497_2	234267.Acid_7887	2.327e-50	183.0	COG0159@1|root,COG0159@2|Bacteria,3Y3X2@57723|Acidobacteria	57723|Acidobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
TLS2_k127_4376497_4	1267535.KB906767_gene283	1.491e-27	116.0	COG1605@1|root,COG1605@2|Bacteria,3Y53J@57723|Acidobacteria	57723|Acidobacteria	E	chorismate mutase	-	-	-	-	-	-	-	-	-	-	-	-	CM_2
TLS2_k127_4376497_0	234267.Acid_7885	1.793e-158	505.0	COG2876@1|root,COG2876@2|Bacteria,3Y2SV@57723|Acidobacteria	57723|Acidobacteria	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
TLS2_k127_4376497_1	234267.Acid_7884	5.579e-69	245.0	COG0287@1|root,COG0287@2|Bacteria,3Y4CK@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Prephenate dehydrogenase	-	-	1.3.1.12	ko:K00210,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
TLS2_k127_4376497_5	1123393.KB891332_gene2774	2.319e-14	82.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2VKF3@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator crp fnr family	crp	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
TLS2_k127_4376497_3	234267.Acid_7354	3.428e-28	123.0	COG0729@1|root,COG0729@2|Bacteria	2|Bacteria	M	surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag
TLS2_k127_4381966_0	1198452.Jab_2c25950	4.048e-227	713.0	COG0665@1|root,COG0665@2|Bacteria,1MU40@1224|Proteobacteria,2VSIK@28216|Betaproteobacteria,476VS@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Tryptophan halogenase	-	-	1.14.19.9	ko:K14266	ko00404,ko01130,map00404,map01130	M00789,M00790	R09570	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_halogenase
TLS2_k127_4381966_1	1449076.JOOE01000005_gene1625	8.755e-162	517.0	COG0644@1|root,COG0644@2|Bacteria,1R41S@1224|Proteobacteria,2TW03@28211|Alphaproteobacteria,2KESW@204457|Sphingomonadales	204457|Sphingomonadales	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
TLS2_k127_4386344_4	1267535.KB906767_gene874	5.398e-95	320.0	COG3375@1|root,COG3375@2|Bacteria,3Y41E@57723|Acidobacteria,2JI86@204432|Acidobacteriia	204432|Acidobacteriia	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4386344_3	234267.Acid_1845	4.41e-104	344.0	COG1694@1|root,COG3956@2|Bacteria,3Y46M@57723|Acidobacteria	57723|Acidobacteria	S	TIGRFAM MazG family protein	-	-	3.6.1.66,3.6.1.9	ko:K02428,ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R01855,R02100,R02720,R03004,R03036,R03531,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
TLS2_k127_4386344_9	1121438.JNJA01000001_gene2312	2.086e-17	91.0	COG0730@1|root,COG0730@2|Bacteria,1RBHH@1224|Proteobacteria,42R9E@68525|delta/epsilon subdivisions,2WNRJ@28221|Deltaproteobacteria,2MAXH@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_4386344_0	234267.Acid_7475	3.093e-206	651.0	COG3119@1|root,COG3119@2|Bacteria,3Y7FV@57723|Acidobacteria	57723|Acidobacteria	P	Protein of unknown function (DUF229)	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_4386344_1	234267.Acid_7134	1.433e-155	505.0	COG4365@1|root,COG4365@2|Bacteria,3Y4D6@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the BshC family	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
TLS2_k127_4386344_7	234267.Acid_5458	9.766e-49	178.0	COG0222@1|root,COG0222@2|Bacteria,3Y50J@57723|Acidobacteria	57723|Acidobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
TLS2_k127_4386344_6	1267535.KB906767_gene4467	4.005e-62	218.0	COG0244@1|root,COG0244@2|Bacteria,3Y4N2@57723|Acidobacteria,2JJ81@204432|Acidobacteriia	204432|Acidobacteriia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
TLS2_k127_4386344_2	1267535.KB906767_gene4466	2.815e-122	394.0	COG0081@1|root,COG0081@2|Bacteria,3Y2HX@57723|Acidobacteria,2JITV@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
TLS2_k127_4386344_8	240015.ACP_2126	2.581e-39	151.0	COG1695@1|root,COG1695@2|Bacteria,3Y4XK@57723|Acidobacteria,2JJR3@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_4386344_5	1340493.JNIF01000003_gene3150	9.162e-77	274.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_4389855_0	1382359.JIAL01000001_gene12	0.0	1124.0	COG1964@1|root,COG1964@2|Bacteria,3Y2WC@57723|Acidobacteria,2JHTH@204432|Acidobacteriia	204432|Acidobacteriia	S	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
TLS2_k127_4396017_2	1179773.BN6_34870	2.98e-62	224.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria,4E0A8@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	ko:K18471	ko00640,map00640	-	R10718	RC00739	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
TLS2_k127_4396017_1	1267535.KB906767_gene4459	1.355e-177	569.0	COG0673@1|root,COG0673@2|Bacteria,3Y2KV@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_4396017_3	1267535.KB906767_gene2854	1.372e-18	102.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,RCC1_2
TLS2_k127_4396017_0	1267535.KB906767_gene2855	0.0	1083.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,OmpA,Plug,RHS_repeat,TonB_dep_Rec
TLS2_k127_4402557_13	395964.KE386496_gene443	2.11e-39	148.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2U5T2@28211|Alphaproteobacteria,3ND07@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Flavodoxin-like fold	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
TLS2_k127_4402557_3	1382359.JIAL01000001_gene1345	1.029e-129	419.0	COG1741@1|root,COG1741@2|Bacteria,3Y4MS@57723|Acidobacteria,2JKK8@204432|Acidobacteriia	204432|Acidobacteriia	S	Pirin C-terminal cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Pirin,Pirin_C
TLS2_k127_4402557_12	1267535.KB906767_gene730	5.128e-46	170.0	COG1846@1|root,COG1846@2|Bacteria,3Y82F@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	ko:K15973	-	-	-	-	ko00000,ko03000	-	-	-	MarR,MarR_2
TLS2_k127_4402557_9	234267.Acid_5692	4.741e-67	240.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,DUF4241
TLS2_k127_4402557_6	1340493.JNIF01000003_gene4558	2.491e-84	292.0	COG1082@1|root,COG1082@2|Bacteria,3Y3CH@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_4402557_18	706587.Desti_0265	3.012e-05	50.0	2EGP4@1|root,33AF9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4402557_15	195250.CM001776_gene331	1.159e-29	125.0	COG1848@1|root,COG1848@2|Bacteria,1GA9D@1117|Cyanobacteria	1117|Cyanobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4402557_11	880073.Calab_0099	2.235e-52	191.0	COG0231@1|root,COG0231@2|Bacteria,2NPID@2323|unclassified Bacteria	2|Bacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TLS2_k127_4402557_1	234267.Acid_3675	1.356e-158	511.0	COG1921@1|root,COG1921@2|Bacteria,3Y39V@57723|Acidobacteria	57723|Acidobacteria	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
TLS2_k127_4402557_4	1267535.KB906767_gene4792	1.224e-105	351.0	COG2120@1|root,COG2120@2|Bacteria,3Y7FS@57723|Acidobacteria	57723|Acidobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_4402557_10	234267.Acid_4014	9.404e-67	243.0	COG0673@1|root,COG0673@2|Bacteria,3Y4KS@57723|Acidobacteria	2|Bacteria	S	PFAM oxidoreductase domain protein	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4402557_17	1198114.AciX9_1579	5.242e-20	101.0	COG1413@1|root,COG1413@2|Bacteria,3Y81E@57723|Acidobacteria,2JNMC@204432|Acidobacteriia	204432|Acidobacteriia	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4402557_8	234267.Acid_3419	2.985e-74	259.0	COG1040@1|root,COG1040@2|Bacteria,3Y4SY@57723|Acidobacteria	57723|Acidobacteria	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
TLS2_k127_4402557_5	1267535.KB906767_gene2821	2.57e-89	297.0	COG1403@1|root,COG1403@2|Bacteria,3Y3PW@57723|Acidobacteria,2JI65@204432|Acidobacteriia	204432|Acidobacteriia	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
TLS2_k127_4402557_0	1340493.JNIF01000003_gene1555	1.359e-281	877.0	COG2133@1|root,COG3258@1|root,COG2133@2|Bacteria,COG3258@2|Bacteria	2|Bacteria	C	Cytochrome c	gdhB	-	1.1.5.2,1.1.9.1,1.8.2.2	ko:K00117,ko:K02030,ko:K17760,ko:K19713	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	M00236	R06620	RC00066	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3	-	-	Cytochrom_C,Cytochrome_CBB3,GSDH,PA14,PQQ,PSCyt3,PSD3,PSD4,PSD5,SBP_bac_3
TLS2_k127_4402557_2	575540.Isop_3679	1.392e-140	458.0	COG3119@1|root,COG3119@2|Bacteria,2IYH5@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.4	ko:K01132	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00077,M00079	R07806	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
TLS2_k127_4402557_14	472175.EL18_00339	2.869e-38	156.0	COG0673@1|root,COG0673@2|Bacteria,1MW74@1224|Proteobacteria,2TSFH@28211|Alphaproteobacteria,43NQS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4402557_7	314230.DSM3645_01936	7.044e-78	273.0	COG3119@1|root,COG3119@2|Bacteria,2IXH3@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_4403917_5	234267.Acid_5690	1.231e-60	218.0	COG1007@1|root,COG1007@2|Bacteria,3Y43Y@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_4403917_1	234267.Acid_5689	3.647e-234	738.0	COG1008@1|root,COG1008@2|Bacteria,3Y3VX@57723|Acidobacteria	57723|Acidobacteria	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_4403917_0	234267.Acid_5688	1.167e-235	750.0	COG1009@1|root,COG1009@2|Bacteria,3Y2VS@57723|Acidobacteria	2|Bacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
TLS2_k127_4403917_7	1340493.JNIF01000003_gene2478	3.589e-40	150.0	COG0713@1|root,COG0713@2|Bacteria,3Y54E@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS2_k127_4403917_6	234267.Acid_5686	1.337e-55	202.0	COG0839@1|root,COG0839@2|Bacteria,3Y5QU@57723|Acidobacteria	57723|Acidobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS2_k127_4403917_3	234267.Acid_5685	1.557e-79	267.0	COG1143@1|root,COG1143@2|Bacteria,3Y529@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
TLS2_k127_4403917_2	234267.Acid_5684	2.19e-207	649.0	COG0649@1|root,COG0649@2|Bacteria,3Y3AB@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS2_k127_4403917_4	234267.Acid_5683	2.116e-70	241.0	COG0852@1|root,COG0852@2|Bacteria,3Y5E8@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TLS2_k127_4407373_3	401053.AciPR4_3581	1.594e-08	59.0	COG0457@1|root,COG0457@2|Bacteria,3Y2IP@57723|Acidobacteria,2JHII@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
TLS2_k127_4407373_0	234267.Acid_1805	6.162e-62	224.0	COG0457@1|root,COG0457@2|Bacteria,3Y5WJ@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4407373_1	234267.Acid_1804	1.152e-59	216.0	COG0571@1|root,COG0571@2|Bacteria,3Y4M2@57723|Acidobacteria	57723|Acidobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
TLS2_k127_4407373_2	1163398.AJJP01000169_gene1153	1.233e-42	173.0	COG4928@1|root,COG4928@2|Bacteria	2|Bacteria	G	KAP family P-loop domain	-	-	-	-	-	-	-	-	-	-	-	-	KAP_NTPase
TLS2_k127_4407616_0	1340493.JNIF01000003_gene1695	4.155e-78	264.0	2CEN7@1|root,2Z9XA@2|Bacteria,3Y7AS@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4407616_2	1123054.KB907705_gene2384	3.017e-30	124.0	COG1569@1|root,COG1569@2|Bacteria,1N1T4@1224|Proteobacteria,1SE91@1236|Gammaproteobacteria,1WZFG@135613|Chromatiales	135613|Chromatiales	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
TLS2_k127_4407616_3	555779.Dthio_PD3775	3.311e-10	63.0	COG4226@1|root,COG4226@2|Bacteria,1PTX8@1224|Proteobacteria,4328E@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	CopG domain protein DNA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4407616_1	156889.Mmc1_2864	6.481e-62	219.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,2U24Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
TLS2_k127_4416102_1	85643.Tmz1t_0632	3.342e-56	206.0	COG0846@1|root,COG1132@1|root,COG0846@2|Bacteria,COG1132@2|Bacteria,1PYW1@1224|Proteobacteria,2WE0M@28216|Betaproteobacteria,2KYCP@206389|Rhodocyclales	206389|Rhodocyclales	K	SIR2-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2
TLS2_k127_4416102_0	582899.Hden_0708	6.979e-69	236.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,3N8G4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
TLS2_k127_4416102_2	1121106.JQKB01000119_gene3518	1.295e-50	183.0	COG3293@1|root,COG3293@2|Bacteria,1NNWK@1224|Proteobacteria	1224|Proteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
TLS2_k127_4419318_2	1197906.CAJQ02000009_gene3521	8.054e-120	387.0	28IYZ@1|root,2Z8WJ@2|Bacteria,1N1QE@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4419318_1	1197906.CAJQ02000009_gene3522	4.174e-124	405.0	COG0451@1|root,COG0451@2|Bacteria,1NA8B@1224|Proteobacteria,2UQD3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	GDP-mannose 4,6 dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS2_k127_4419318_0	670307.HYPDE_29593	3.278e-197	622.0	COG0500@1|root,COG0500@2|Bacteria,1MVD1@1224|Proteobacteria,2TUKG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
TLS2_k127_4422511_4	639030.JHVA01000001_gene1888	3.801e-81	287.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	betC	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	Choline_sulf_C,DUF4976,Sulfatase
TLS2_k127_4422511_0	1340493.JNIF01000004_gene88	1.006e-279	900.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_4422511_1	1123242.JH636435_gene2614	1.056e-191	613.0	COG3119@1|root,COG3119@2|Bacteria,2IWVY@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
TLS2_k127_4422511_3	1340493.JNIF01000003_gene4574	3.063e-171	549.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_4422511_2	1340493.JNIF01000003_gene4575	7.875e-178	580.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Laminin_G_3,PSCyt1,PSCyt2,PSD1
TLS2_k127_4424448_6	926566.Terro_1781	9.727e-72	251.0	COG3458@1|root,COG3458@2|Bacteria,3Y7GC@57723|Acidobacteria	57723|Acidobacteria	Q	cephalosporin-C deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4424448_1	234267.Acid_2989	5.497e-196	623.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.99	ko:K06113	-	-	-	-	ko00000,ko01000	-	GH43	-	Glyco_hydro_43,RicinB_lectin_2
TLS2_k127_4424448_0	1449049.JONW01000001_gene3370	3.462e-233	730.0	COG3534@1|root,COG3534@2|Bacteria,1PPWJ@1224|Proteobacteria,2TWSD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
TLS2_k127_4424448_3	311402.Avi_5711	1.419e-127	434.0	COG1653@1|root,COG1653@2|Bacteria,1R5H8@1224|Proteobacteria,2U0T7@28211|Alphaproteobacteria,4BBZS@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC-type sugar transport system, periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_4424448_4	311402.Avi_5710	2.274e-113	383.0	COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,2TSYA@28211|Alphaproteobacteria,4BMAQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_4424448_5	595494.Tola_1711	2.359e-99	332.0	COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,1RYI1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_4424448_2	794846.AJQU01000008_gene2172	5.656e-134	436.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,4BAN4@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
TLS2_k127_4424448_7	870187.Thini_4237	3.922e-67	232.0	COG2253@1|root,COG2253@2|Bacteria,1R3R3@1224|Proteobacteria,1S0PT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
TLS2_k127_4424448_8	1121382.JQKG01000016_gene1630	2.221e-47	184.0	COG3867@1|root,COG5297@1|root,COG3867@2|Bacteria,COG5297@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase family 6	-	-	3.2.1.4,3.2.1.78,3.2.1.8,3.2.1.91	ko:K01179,ko:K01181,ko:K01218,ko:K19668	ko00051,ko00500,ko01100,ko02020,ko02024,map00051,map00500,map01100,map02020,map02024	-	R01332,R02886,R06200,R11307,R11308	RC00467,RC00799	ko00000,ko00001,ko01000	-	GH26,GH5,GH6,GH9	-	Big_4,CBM60,CBM_10,CBM_2,Cellulase,F5_F8_type_C,Glyco_hydro_10,Glyco_hydro_12,Glyco_hydro_53,He_PIG,Malectin,RicinB_lectin_2
TLS2_k127_4424448_9	323261.Noc_0857	4.383e-45	175.0	COG2138@1|root,COG2138@2|Bacteria,1NMVC@1224|Proteobacteria,1SVSQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cobalamin (vitamin B12) biosynthesis CbiX protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4425180_8	395965.Msil_3484	1.314e-24	109.0	COG4113@1|root,COG4113@2|Bacteria,1NEE2@1224|Proteobacteria,2UJ3R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_4425180_11	105559.Nwat_1260	2.456e-08	59.0	2A6UU@1|root,30VP8@2|Bacteria,1NQ5B@1224|Proteobacteria,1SUYT@1236|Gammaproteobacteria,1X1Y1@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4425180_0	234267.Acid_7871	3.646e-169	549.0	COG0616@1|root,COG0616@2|Bacteria,3Y3M1@57723|Acidobacteria	57723|Acidobacteria	OU	PFAM peptidase S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TLS2_k127_4425180_3	1340493.JNIF01000003_gene2620	3.984e-87	297.0	COG1191@1|root,COG1191@2|Bacteria,3Y6IE@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70, region 4	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
TLS2_k127_4425180_5	1340493.JNIF01000003_gene3597	5.569e-54	203.0	COG0810@1|root,COG0810@2|Bacteria,3Y3T5@57723|Acidobacteria	57723|Acidobacteria	M	TonB C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_2,TonB_C
TLS2_k127_4425180_2	234267.Acid_6205	2.682e-103	346.0	COG0673@1|root,COG0673@2|Bacteria,3Y3ET@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_4425180_10	234267.Acid_4003	5.271e-16	83.0	COG4206@1|root,COG4206@2|Bacteria	2|Bacteria	H	cobalamin-transporting ATPase activity	oar1	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_4425180_6	639030.JHVA01000001_gene1877	2.613e-40	154.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_4425180_9	639030.JHVA01000001_gene1886	7.315e-22	99.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_4425180_7	234267.Acid_3656	3.53e-26	115.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
TLS2_k127_4425180_4	1267535.KB906767_gene1026	4.632e-81	289.0	COG0673@1|root,COG0673@2|Bacteria,3Y6VS@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_4425180_1	1340493.JNIF01000003_gene3109	1.476e-157	505.0	COG2133@1|root,COG2133@2|Bacteria,3Y3YZ@57723|Acidobacteria	57723|Acidobacteria	G	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS2_k127_4431179_1	234267.Acid_1177	5.432e-114	374.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
TLS2_k127_4431179_0	234267.Acid_7028	1.036e-155	503.0	COG0154@1|root,COG0154@2|Bacteria	2|Bacteria	J	amidase activity	gatA3	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_4431179_3	234267.Acid_4154	1.049e-101	362.0	COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_4431179_4	596154.Alide2_1766	4.273e-98	329.0	COG1388@1|root,COG1388@2|Bacteria,1MY1S@1224|Proteobacteria,2VZIM@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
TLS2_k127_4431179_5	1267534.KB906759_gene1645	1.288e-49	182.0	COG2764@1|root,COG2764@2|Bacteria	2|Bacteria	E	glyoxalase bleomycin resistance protein dioxygenase	MA20_04095	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt,YCII
TLS2_k127_4431179_2	1173026.Glo7428_4499	3.545e-110	366.0	COG1028@1|root,COG1028@2|Bacteria,1GQ3F@1117|Cyanobacteria	1117|Cyanobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_4433541_8	1340493.JNIF01000004_gene454	1.173e-31	129.0	COG1249@1|root,COG1249@2|Bacteria	2|Bacteria	C	cell redox homeostasis	M1-534	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored,SLH
TLS2_k127_4433541_10	1267535.KB906767_gene4633	2.784e-21	100.0	2EQJB@1|root,33I5C@2|Bacteria,3Y5WN@57723|Acidobacteria,2JNK1@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4433541_4	402626.Rpic_4856	5.94e-120	405.0	28K8V@1|root,2Z9WK@2|Bacteria,1R70Q@1224|Proteobacteria,2WE5K@28216|Betaproteobacteria,1KBTT@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PhoD-like phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4433541_2	1340493.JNIF01000004_gene234	2.11e-217	704.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_4433541_3	1340493.JNIF01000004_gene233	2.378e-191	608.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_4433541_7	663610.JQKO01000012_gene3076	3.139e-73	267.0	COG0491@1|root,COG0491@2|Bacteria,1R6GR@1224|Proteobacteria,2U3IN@28211|Alphaproteobacteria,3NCAY@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_4433541_5	1267535.KB906767_gene3950	4.178e-116	392.0	COG2010@1|root,COG2010@2|Bacteria,3Y44D@57723|Acidobacteria,2JMAT@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4433541_0	234267.Acid_2857	0.0	1163.0	COG3808@1|root,COG3808@2|Bacteria,3Y34E@57723|Acidobacteria	57723|Acidobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS2_k127_4433541_6	234267.Acid_0345	3.771e-107	353.0	COG3253@1|root,COG3253@2|Bacteria,3Y39D@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
TLS2_k127_4433541_1	1340493.JNIF01000004_gene88	6.508e-277	891.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_4433541_9	756272.Plabr_2497	1.03e-26	114.0	COG3119@1|root,COG3119@2|Bacteria,2IWX1@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
TLS2_k127_4436460_1	1267535.KB906767_gene1027	7.983e-127	413.0	COG3267@1|root,COG3267@2|Bacteria,3Y6KP@57723|Acidobacteria	57723|Acidobacteria	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
TLS2_k127_4436460_0	1267535.KB906767_gene75	1.707e-135	445.0	COG1181@1|root,COG1181@2|Bacteria,3Y7GI@57723|Acidobacteria	57723|Acidobacteria	M	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
TLS2_k127_4436460_2	234267.Acid_0477	1.598e-47	178.0	COG2924@1|root,COG2924@2|Bacteria,3Y4ZS@57723|Acidobacteria	57723|Acidobacteria	CO	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
TLS2_k127_4436460_4	1340493.JNIF01000004_gene155	4.231e-15	89.0	COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	CARDB,Calx-beta,CarboxypepD_reg,He_PIG,Laminin_G_3,NHL,SGL
TLS2_k127_4436460_3	234267.Acid_3694	1.282e-40	170.0	COG1075@1|root,COG1075@2|Bacteria,3Y8K4@57723|Acidobacteria	57723|Acidobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4436460_5	1382359.JIAL01000001_gene2682	7.407e-09	57.0	COG0534@1|root,COG0534@2|Bacteria,3Y2U1@57723|Acidobacteria,2JIPP@204432|Acidobacteriia	204432|Acidobacteriia	V	efflux protein, MATE family	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
TLS2_k127_4437285_1	204669.Acid345_3294	1.585e-58	222.0	COG2982@1|root,COG2982@2|Bacteria,3Y4F7@57723|Acidobacteria,2JMVH@204432|Acidobacteriia	204432|Acidobacteriia	M	AsmA-like C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
TLS2_k127_4437285_0	107635.AZUO01000003_gene4097	2.874e-99	329.0	COG3316@1|root,COG3316@2|Bacteria,1MWZ2@1224|Proteobacteria,2U2PF@28211|Alphaproteobacteria,36ZQ0@31993|Methylocystaceae	28211|Alphaproteobacteria	L	DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
TLS2_k127_4437285_2	348824.LPU83_4145	5.571e-31	124.0	2C19F@1|root,32ZRH@2|Bacteria,1NJ8W@1224|Proteobacteria,2V4D2@28211|Alphaproteobacteria,4BFUV@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4443217_1	261292.Nit79A3_1297	7.544e-63	219.0	COG3221@1|root,COG3221@2|Bacteria,1N92V@1224|Proteobacteria,2WBUH@28216|Betaproteobacteria,373TX@32003|Nitrosomonadales	28216|Betaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Phosphonate-bd
TLS2_k127_4443217_0	261292.Nit79A3_1298	1.419e-150	485.0	COG0425@1|root,COG0425@2|Bacteria,1R8DP@1224|Proteobacteria,2WFJB@28216|Betaproteobacteria,373Y3@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	AurF
TLS2_k127_4443822_0	1124780.ANNU01000032_gene1216	2.505e-84	306.0	COG0642@1|root,COG2202@1|root,COG4191@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,COG4251@2|Bacteria,4NE3J@976|Bacteroidetes,47MRF@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase	rcsC3	-	-	-	-	-	-	-	-	-	-	-	CZB,HATPase_c,HisKA,PAS_10,PAS_3,PAS_4,PAS_9
TLS2_k127_444615_0	234267.Acid_3103	2.808e-113	370.0	COG4948@1|root,COG4948@2|Bacteria,3Y46A@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Mandelate racemase muconate lactonizing enzyme, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C
TLS2_k127_444615_2	1267535.KB906767_gene3210	5.889e-47	181.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_444615_1	1267535.KB906767_gene3210	3.945e-48	185.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_444615_3	344747.PM8797T_14594	2.566e-37	145.0	COG3119@1|root,COG3119@2|Bacteria,2IYRK@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_4448716_0	70601.3257463	8.848e-08	59.0	COG2309@1|root,arCOG01890@2157|Archaea,2XU28@28890|Euryarchaeota,243WP@183968|Thermococci	183968|Thermococci	E	Thermophilic metalloprotease (M29)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
TLS2_k127_4458587_1	497964.CfE428DRAFT_1016	3.248e-77	264.0	COG3119@1|root,COG3119@2|Bacteria,46Z34@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_4458587_0	886293.Sinac_5109	2.532e-125	410.0	COG2010@1|root,COG2010@2|Bacteria,2IXIG@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_4459909_1	452637.Oter_4517	1.935e-157	507.0	COG0673@1|root,COG0673@2|Bacteria,46UJR@74201|Verrucomicrobia,3K94Y@414999|Opitutae	2|Bacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4459909_6	335543.Sfum_1656	1.234e-46	178.0	COG1234@1|root,COG1234@2|Bacteria,1PE64@1224|Proteobacteria,42RZR@68525|delta/epsilon subdivisions,2WNPZ@28221|Deltaproteobacteria,2MS6E@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_4459909_0	314230.DSM3645_09722	2.11e-159	514.0	COG3119@1|root,COG3119@2|Bacteria,2IYH5@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_4459909_4	344747.PM8797T_18384	3.079e-108	365.0	COG0673@1|root,COG0673@2|Bacteria,2IWRC@203682|Planctomycetes	203682|Planctomycetes	S	COGs COG0673 dehydrogenase and related protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_4459909_2	234267.Acid_5620	5.555e-154	500.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.294,2.7.1.181	ko:K18827	-	-	R10657,R10658	RC00002,RC00003,RC00078,RC03220	ko00000,ko01000,ko01005	-	-	-	DUF4214,Glycos_transf_2,Methyltransf_11,Methyltransf_21,Methyltransf_23,Methyltransf_25
TLS2_k127_4459909_5	234267.Acid_5619	2.922e-55	196.0	COG0780@1|root,COG0780@2|Bacteria,3Y4ND@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
TLS2_k127_4459909_3	234267.Acid_5618	1.674e-139	448.0	COG1915@1|root,COG1915@2|Bacteria,3Y6MM@57723|Acidobacteria	57723|Acidobacteria	S	LOR/SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
TLS2_k127_4462299_0	744872.Spica_1978	4.465e-77	269.0	COG0428@1|root,COG0428@2|Bacteria,2J6TD@203691|Spirochaetes	203691|Spirochaetes	P	PFAM zinc iron permease	zupT	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
TLS2_k127_4470202_1	234267.Acid_7352	4.894e-128	424.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K07709,ko:K07710	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS_10,PAS_4
TLS2_k127_4470202_0	234267.Acid_7351	1.31e-201	636.0	COG2204@1|root,COG2204@2|Bacteria,3Y2J1@57723|Acidobacteria	57723|Acidobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_4470202_2	1121405.dsmv_0916	1.009e-20	98.0	COG0500@1|root,COG2226@2|Bacteria,1QVT4@1224|Proteobacteria,43BQZ@68525|delta/epsilon subdivisions,2X71X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_4478851_2	204669.Acid345_4092	5.138e-67	231.0	COG0009@1|root,COG0009@2|Bacteria,3Y3VW@57723|Acidobacteria,2JHTT@204432|Acidobacteriia	204432|Acidobacteriia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
TLS2_k127_4478851_0	1267535.KB906767_gene4419	3.457e-172	546.0	COG1186@1|root,COG1186@2|Bacteria,3Y2ZM@57723|Acidobacteria,2JIGW@204432|Acidobacteriia	204432|Acidobacteriia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS2_k127_4478851_1	234267.Acid_0909	3.541e-85	288.0	COG0565@1|root,COG0565@2|Bacteria,3Y4F6@57723|Acidobacteria	57723|Acidobacteria	J	PFAM tRNA rRNA methyltransferase, SpoU	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
TLS2_k127_4478851_3	234267.Acid_7029	1.679e-45	171.0	COG1295@1|root,COG1295@2|Bacteria,3Y3AJ@57723|Acidobacteria	57723|Acidobacteria	S	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_4481219_3	1198114.AciX9_3662	2.496e-26	116.0	COG0265@1|root,COG0265@2|Bacteria,3Y99F@57723|Acidobacteria,2JJ0S@204432|Acidobacteriia	204432|Acidobacteriia	O	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
TLS2_k127_4481219_2	234267.Acid_0376	4.251e-95	331.0	COG0454@1|root,COG0456@2|Bacteria,3Y3VJ@57723|Acidobacteria	57723|Acidobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_4481219_1	234267.Acid_1175	2.413e-220	692.0	COG0531@1|root,COG0531@2|Bacteria,3Y2R3@57723|Acidobacteria	57723|Acidobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_4481219_0	1267535.KB906767_gene1001	0.0	1084.0	COG0210@1|root,COG0210@2|Bacteria,3Y2W8@57723|Acidobacteria,2JIDH@204432|Acidobacteriia	204432|Acidobacteriia	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS2_k127_4492491_6	234267.Acid_3591	1.089e-73	258.0	COG1878@1|root,COG1878@2|Bacteria,3Y72H@57723|Acidobacteria	57723|Acidobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_4492491_1	1267535.KB906767_gene265	2.237e-185	594.0	COG0443@1|root,COG0443@2|Bacteria	2|Bacteria	O	unfolded protein binding	hscA	-	-	-	-	-	-	-	-	-	-	-	HSP70,RNase_Zc3h12a
TLS2_k127_4492491_8	204669.Acid345_4326	2.235e-63	226.0	COG1235@1|root,COG1235@2|Bacteria,3Y3DW@57723|Acidobacteria,2JI3X@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_4492491_0	1267535.KB906767_gene5065	2.227e-188	599.0	COG0015@1|root,COG0015@2|Bacteria,3Y2QW@57723|Acidobacteria,2JIAC@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
TLS2_k127_4492491_10	1267535.KB906767_gene5066	3.844e-41	161.0	COG0784@1|root,COG0784@2|Bacteria,3Y8JB@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4492491_5	1340493.JNIF01000003_gene1320	6.126e-77	266.0	COG2945@1|root,COG2945@2|Bacteria,3Y35I@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4
TLS2_k127_4492491_7	1267535.KB906767_gene2255	7.515e-72	245.0	COG1666@1|root,COG1666@2|Bacteria,3Y4I3@57723|Acidobacteria,2JJ8P@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the UPF0234 family	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
TLS2_k127_4492491_9	234267.Acid_3193	3.621e-48	179.0	COG2199@1|root,COG3706@2|Bacteria,3Y5QC@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_4492491_2	1340493.JNIF01000003_gene1323	1.599e-145	474.0	COG4105@1|root,COG4105@2|Bacteria,3Y36S@57723|Acidobacteria	57723|Acidobacteria	S	TIGRFAM Outer membrane assembly lipoprotein YfiO	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	TPR_6,YfiO
TLS2_k127_4492491_3	234267.Acid_3191	1.188e-87	294.0	COG0036@1|root,COG0036@2|Bacteria,3Y3YN@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TLS2_k127_4492491_11	1172181.KB911701_gene928	6.836e-19	97.0	COG1120@1|root,COG1120@2|Bacteria,2I3B3@201174|Actinobacteria	201174|Actinobacteria	HP	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system	hmuV	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
TLS2_k127_4492491_4	1245469.S58_11380	1.942e-77	268.0	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2U1MK@28211|Alphaproteobacteria,3JVKU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix isocitrate lyase regulation	MA20_26910	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
TLS2_k127_4492491_12	313596.RB2501_01216	1.602e-08	57.0	COG3119@1|root,COG3119@2|Bacteria,4NEM3@976|Bacteroidetes,1HZWB@117743|Flavobacteriia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_4494480_3	1499967.BAYZ01000153_gene1545	1.419e-12	70.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
TLS2_k127_4494480_1	398580.Dshi_0636	2.666e-67	237.0	COG0400@1|root,COG0400@2|Bacteria,1N31B@1224|Proteobacteria	1224|Proteobacteria	S	Phospholipase Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
TLS2_k127_4494480_0	1294273.roselon_00430	9.046e-138	445.0	COG0346@1|root,COG0346@2|Bacteria,1P6TT@1224|Proteobacteria,2TQXR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	mhqO	-	-	ko:K15242,ko:K15975	ko00361,ko01100,ko01120,ko01220,map00361,map01100,map01120,map01220	-	R05408	RC02673	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
TLS2_k127_4494480_2	1504981.KO116_0175	3.526e-29	117.0	COG3576@1|root,COG3576@2|Bacteria,1QUBS@1224|Proteobacteria,1T1SA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
TLS2_k127_4498470_0	644966.Tmar_0341	1.379e-70	258.0	COG4584@1|root,COG4584@2|Bacteria,1TR5X@1239|Firmicutes,25D02@186801|Clostridia	186801|Clostridia	L	integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_7,Mu-transpos_C,rve
TLS2_k127_4498470_1	1121468.AUBR01000052_gene1613	1.698e-38	154.0	COG1484@1|root,COG1484@2|Bacteria,1TPPI@1239|Firmicutes,24DKZ@186801|Clostridia,42FBN@68295|Thermoanaerobacterales	186801|Clostridia	L	IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
TLS2_k127_4498470_3	909663.KI867150_gene2770	8.115e-07	52.0	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
TLS2_k127_4498669_3	1340493.JNIF01000003_gene3101	1.542e-83	288.0	COG0392@1|root,COG0392@2|Bacteria,3Y7S6@57723|Acidobacteria	57723|Acidobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
TLS2_k127_4498669_1	1047013.AQSP01000142_gene209	1.373e-132	450.0	COG1629@1|root,COG4771@2|Bacteria,2NR02@2323|unclassified Bacteria	2|Bacteria	P	TonB dependent receptor	-	-	-	ko:K16089	-	-	-	-	ko00000,ko02000	1.B.14.1,1.B.14.10	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
TLS2_k127_4498669_4	1123368.AUIS01000010_gene2389	1.245e-14	81.0	COG0526@1|root,COG0526@2|Bacteria,1N726@1224|Proteobacteria	1224|Proteobacteria	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	resA	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_4498669_0	497964.CfE428DRAFT_4241	4.384e-135	439.0	COG4409@1|root,COG4409@2|Bacteria,46SCF@74201|Verrucomicrobia	74201|Verrucomicrobia	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_4498669_2	382464.ABSI01000011_gene2591	2.175e-90	306.0	COG2273@1|root,COG2273@2|Bacteria,46UCB@74201|Verrucomicrobia,2IUFQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Glycosyl hydrolases family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
TLS2_k127_4498669_5	204669.Acid345_3217	4.872e-08	62.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	MtrB_PioB,OMP_b-brl
TLS2_k127_4499286_1	1267535.KB906767_gene3460	2.238e-107	356.0	COG1721@1|root,COG1721@2|Bacteria,3Y6DV@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_4499286_0	234267.Acid_5744	3.561e-128	429.0	COG2304@1|root,COG2304@2|Bacteria,3Y6TM@57723|Acidobacteria	57723|Acidobacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
TLS2_k127_4500780_1	261292.Nit79A3_3046	3.961e-80	273.0	COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,2VK4G@28216|Betaproteobacteria,37273@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_4500780_4	1040987.AZUY01000065_gene4144	2.571e-11	67.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2TU3I@28211|Alphaproteobacteria,43HT7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Cytochrome BD ubiquinol oxidase subunit II	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
TLS2_k127_4500780_0	666681.M301_0545	5.592e-120	392.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2VHMU@28216|Betaproteobacteria,2KP6A@206350|Nitrosomonadales	206350|Nitrosomonadales	O	DnaJ molecular chaperone homology domain	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
TLS2_k127_4500780_5	314345.SPV1_02177	1.457e-05	51.0	COG0789@1|root,COG0789@2|Bacteria,1N9MT@1224|Proteobacteria	1224|Proteobacteria	K	MerR HTH family regulatory protein	cbpM	-	-	ko:K18997	-	-	-	-	ko00000,ko03036	-	-	-	MerR_2
TLS2_k127_4500780_2	697282.Mettu_0012	3.262e-70	240.0	COG0662@1|root,COG0662@2|Bacteria,1RJ7D@1224|Proteobacteria,1SBIG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_4500780_3	234267.Acid_5771	3.506e-22	101.0	COG2010@1|root,COG2010@2|Bacteria,3Y5Q0@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS2_k127_4501118_4	234267.Acid_3567	3.56e-71	247.0	COG0739@1|root,COG0739@2|Bacteria,3Y3N4@57723|Acidobacteria	57723|Acidobacteria	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_4501118_7	1340493.JNIF01000003_gene4065	3.987e-28	128.0	COG1426@1|root,COG1426@2|Bacteria,3Y5KP@57723|Acidobacteria	57723|Acidobacteria	S	Helix-turn-helix domain	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
TLS2_k127_4501118_1	234267.Acid_6302	3.047e-121	400.0	COG1216@1|root,COG1216@2|Bacteria,3Y5FE@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_4501118_0	234267.Acid_6301	1.445e-121	403.0	COG2227@1|root,COG2227@2|Bacteria,3Y8XU@57723|Acidobacteria	57723|Acidobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS2_k127_4501118_3	234267.Acid_6300	4.882e-75	258.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_25,Methyltransf_31,TehB
TLS2_k127_4501118_2	1267535.KB906767_gene4620	4.714e-86	294.0	COG2234@1|root,COG2234@2|Bacteria,3Y406@57723|Acidobacteria,2JIRZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_4501118_6	234267.Acid_7737	5.698e-48	175.0	COG0662@1|root,COG0662@2|Bacteria,3Y7HE@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_4501118_5	1340493.JNIF01000004_gene755	8.566e-62	222.0	COG2382@1|root,COG2382@2|Bacteria,3Y5EH@57723|Acidobacteria	57723|Acidobacteria	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
TLS2_k127_4501315_1	1340493.JNIF01000003_gene1440	3.041e-318	985.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	4.2.2.3	ko:K01729	ko00051,map00051	-	R03706	-	ko00000,ko00001,ko01000	-	-	-	Beta_helix,Chondroitinas_B
TLS2_k127_4501315_2	1121904.ARBP01000040_gene533	2.372e-71	254.0	COG2319@1|root,COG2319@2|Bacteria,4P448@976|Bacteroidetes,47VHG@768503|Cytophagia	976|Bacteroidetes	S	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	WD40
TLS2_k127_4501315_4	1210884.HG799462_gene7910	6.551e-20	97.0	COG1520@1|root,COG1520@2|Bacteria,2IYRB@203682|Planctomycetes	2|Bacteria	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_4501315_5	1280952.HJA_01795	0.0006192	51.0	2AFK2@1|root,315KZ@2|Bacteria,1PVSG@1224|Proteobacteria,2V718@28211|Alphaproteobacteria,43YV4@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
TLS2_k127_4501315_3	383372.Rcas_0342	3.87e-29	119.0	COG4281@1|root,COG4281@2|Bacteria,2G98T@200795|Chloroflexi,377KT@32061|Chloroflexia	32061|Chloroflexia	I	PFAM acyl-coA-binding protein, ACBP	-	-	-	-	-	-	-	-	-	-	-	-	ACBP
TLS2_k127_4501315_0	1267535.KB906767_gene1293	0.0	1238.0	COG4206@1|root,COG4206@2|Bacteria	2|Bacteria	H	cobalamin-transporting ATPase activity	oar1	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_4508546_0	497964.CfE428DRAFT_6579	4.495e-68	234.0	COG3832@1|root,COG3832@2|Bacteria,46SRI@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_4508546_1	1095769.CAHF01000009_gene1377	2.983e-55	209.0	COG5592@1|root,COG5592@2|Bacteria,1RCHC@1224|Proteobacteria,2VQQY@28216|Betaproteobacteria,474EQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS2_k127_4508546_2	864069.MicloDRAFT_00032960	8.114e-26	111.0	COG3861@1|root,COG3861@2|Bacteria,1ND73@1224|Proteobacteria,2UFIZ@28211|Alphaproteobacteria,1JW0F@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF2382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382
TLS2_k127_4518858_1	234267.Acid_3133	3.591e-69	239.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,3Y7SH@57723|Acidobacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,PD40,TPR_10,TPR_12,TPR_8
TLS2_k127_4518858_0	234267.Acid_3135	4.251e-111	376.0	COG1404@1|root,COG1404@2|Bacteria,3Y97E@57723|Acidobacteria	2|Bacteria	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	aprE	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009405,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030312,GO:0031224,GO:0031226,GO:0032879,GO:0040007,GO:0043170,GO:0044238,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0051046,GO:0051049,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.21.111,3.4.21.62,3.4.21.66	ko:K01342,ko:K08651,ko:K14645,ko:K14743,ko:K20486,ko:K20754	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I9,PPC,P_proprotein,Peptidase_S8
TLS2_k127_4518858_2	358396.C445_12896	4.579e-23	105.0	COG0784@1|root,arCOG02589@2157|Archaea,2XVUK@28890|Euryarchaeota,23V7T@183963|Halobacteria	183963|Halobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_4524180_0	402777.KB235904_gene4630	3.953e-151	488.0	COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria,1H97S@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_4525718_1	1123508.JH636451_gene5950	2.235e-07	59.0	COG4886@1|root,COG4886@2|Bacteria,2J2ZP@203682|Planctomycetes	203682|Planctomycetes	S	Leucine Rich repeat	-	-	-	-	-	-	-	-	-	-	-	-	LRR_6
TLS2_k127_4525718_0	1210884.HG799468_gene13690	2.65e-123	433.0	COG3653@1|root,COG3653@2|Bacteria,2IXWQ@203682|Planctomycetes	203682|Planctomycetes	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
TLS2_k127_4526520_1	1379270.AUXF01000002_gene1329	9.966e-166	535.0	COG1404@1|root,COG1404@2|Bacteria,1ZUQ8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS2_k127_4526520_0	1267535.KB906767_gene5287	2.322e-174	554.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4526520_2	1267535.KB906767_gene3042	4.65e-117	388.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4526520_3	234267.Acid_1753	1.035e-55	215.0	2BZ8T@1|root,33VM1@2|Bacteria,3Y7Y3@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4526520_4	204669.Acid345_0607	8.472e-24	111.0	COG3170@1|root,COG5373@1|root,COG3170@2|Bacteria,COG5373@2|Bacteria,3Y44X@57723|Acidobacteria,2JHIB@204432|Acidobacteriia	204432|Acidobacteriia	NU	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
TLS2_k127_4529757_5	402777.KB235903_gene1225	4.379e-51	188.0	COG2162@1|root,COG2162@2|Bacteria,1G3CG@1117|Cyanobacteria,1HA7I@1150|Oscillatoriales	1117|Cyanobacteria	Q	N-acetyltransferase	-	-	2.3.1.118	ko:K00675	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_2
TLS2_k127_4529757_6	1454004.AW11_02685	1.303e-38	160.0	28JIP@1|root,2Z82C@2|Bacteria,1R5N9@1224|Proteobacteria,2VRZW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	S1/P1 Nuclease	-	-	-	-	-	-	-	-	-	-	-	-	S1-P1_nuclease
TLS2_k127_4529757_2	234267.Acid_3049	1.027e-76	269.0	COG0739@1|root,COG0739@2|Bacteria,3Y5PX@57723|Acidobacteria	57723|Acidobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_4529757_0	1267535.KB906767_gene1210	0.0	1035.0	COG4932@1|root,COG4932@2|Bacteria,3Y3KQ@57723|Acidobacteria,2JMAN@204432|Acidobacteriia	57723|Acidobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_4529757_3	1173024.KI912149_gene5721	3.213e-54	199.0	COG1073@1|root,COG1073@2|Bacteria,1G4HS@1117|Cyanobacteria,1JKRS@1189|Stigonemataceae	1117|Cyanobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS2_k127_4529757_4	1382306.JNIM01000001_gene1928	1.703e-53	198.0	COG0596@1|root,COG0596@2|Bacteria,2GA9A@200795|Chloroflexi	200795|Chloroflexi	S	COGs COG0596 hydrolase or acyltransferase (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_4529757_1	1340493.JNIF01000003_gene4346	2.802e-142	460.0	COG1085@1|root,COG1085@2|Bacteria,3Y41K@57723|Acidobacteria	57723|Acidobacteria	C	Galactose-1-phosphate uridyl transferase, N-terminal domain	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
TLS2_k127_4529757_7	37919.EP51_07750	7.958e-15	78.0	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4G1R8@85025|Nocardiaceae	201174|Actinobacteria	L	Belongs to the UPF0102 family	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
TLS2_k127_4530433_2	1340493.JNIF01000003_gene2563	5.192e-92	306.0	COG0623@1|root,COG0623@2|Bacteria,3Y3EN@57723|Acidobacteria	57723|Acidobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_4530433_0	886293.Sinac_6486	6.951e-139	460.0	COG1574@1|root,COG1574@2|Bacteria,2IXY4@203682|Planctomycetes	203682|Planctomycetes	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_4530433_3	234267.Acid_5333	1.954e-90	313.0	COG0154@1|root,COG0154@2|Bacteria,3Y6E5@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Amidase	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_4530433_4	234267.Acid_6462	8.844e-63	225.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_3,PAS_4
TLS2_k127_4530433_1	1340493.JNIF01000004_gene438	2.481e-99	330.0	COG2197@1|root,COG2197@2|Bacteria,3Y6T2@57723|Acidobacteria	57723|Acidobacteria	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_4537974_5	1267535.KB906767_gene1678	1.227e-24	104.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_4537974_3	234267.Acid_5579	1.378e-40	154.0	COG5592@1|root,COG5592@2|Bacteria	2|Bacteria	I	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin,Phasin_2
TLS2_k127_4537974_0	314230.DSM3645_23311	2.408e-86	297.0	COG1680@1|root,COG1680@2|Bacteria,2IZJ5@203682|Planctomycetes	203682|Planctomycetes	V	COG1680 Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_4537974_4	1183438.GKIL_1584	3.758e-39	151.0	COG3682@1|root,COG3682@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
TLS2_k127_4537974_2	1340493.JNIF01000003_gene2365	2.225e-54	217.0	COG4219@1|root,COG4219@2|Bacteria,3Y5DY@57723|Acidobacteria	57723|Acidobacteria	KT	PFAM Peptidase M56, BlaR1	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
TLS2_k127_4537974_1	1121861.KB899924_gene3556	9.235e-81	287.0	COG2807@1|root,COG2807@2|Bacteria,1QUCZ@1224|Proteobacteria,2TY3D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4537974_6	760117.JN27_15060	0.0002096	46.0	COG2072@1|root,COG2072@2|Bacteria,1QW8X@1224|Proteobacteria	1224|Proteobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_3
TLS2_k127_4549757_2	1144319.PMI16_03975	1.319e-113	376.0	COG2141@1|root,COG2141@2|Bacteria,1MVF0@1224|Proteobacteria,2VP68@28216|Betaproteobacteria,478FJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	TIGRFAM luciferase family oxidoreductase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_4549757_0	1267535.KB906767_gene2828	4.991e-288	891.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_4549757_1	1340493.JNIF01000003_gene2866	5.374e-184	584.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4549757_3	234267.Acid_3318	4.175e-32	127.0	COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_4560324_4	596152.DesU5LDRAFT_0265	1.404e-59	215.0	COG4359@1|root,COG4359@2|Bacteria,1NMH7@1224|Proteobacteria,42UTM@68525|delta/epsilon subdivisions,2WQSI@28221|Deltaproteobacteria,2MATN@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	HAD-superfamily hydrolase, subfamily IB	-	-	3.1.3.87	ko:K08966	ko00270,ko01100,map00270,map01100	M00034	R07394	RC02074	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD
TLS2_k127_4560324_2	1192034.CAP_4195	5.594e-130	424.0	COG0371@1|root,COG0371@2|Bacteria,1NAAM@1224|Proteobacteria	1224|Proteobacteria	C	Glycerol dehydrogenase and related enzymes	-	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
TLS2_k127_4560324_5	234267.Acid_6639	4.503e-48	183.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_4560324_1	278963.ATWD01000001_gene2919	6.577e-190	638.0	COG1629@1|root,COG4771@2|Bacteria,3Y778@57723|Acidobacteria,2JKG8@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_4560324_7	234267.Acid_7948	1.426e-33	138.0	2E6AH@1|root,330YD@2|Bacteria,3Y8MQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4560324_6	234267.Acid_7948	6.495e-38	149.0	2E6AH@1|root,330YD@2|Bacteria,3Y8MQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4560324_3	234267.Acid_5550	5.146e-119	391.0	COG4223@1|root,COG4223@2|Bacteria,3Y6G5@57723|Acidobacteria	57723|Acidobacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4560324_0	234267.Acid_0981	0.0	1010.0	COG0443@1|root,COG0443@2|Bacteria,3Y7FW@57723|Acidobacteria	57723|Acidobacteria	O	DNA-K related protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3731,HSP70
TLS2_k127_4568647_0	396588.Tgr7_0938	8.255e-120	398.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1WWKF@135613|Chromatiales	135613|Chromatiales	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
TLS2_k127_4568647_1	314278.NB231_16043	2.109e-85	286.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1WW24@135613|Chromatiales	135613|Chromatiales	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TLS2_k127_457707_2	929713.NIASO_09810	1.241e-38	157.0	COG3342@1|root,COG3342@2|Bacteria	2|Bacteria	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028,MAM,Peptidase_M14,fn3
TLS2_k127_457707_3	595460.RRSWK_04461	1.913e-20	95.0	COG0673@1|root,COG0673@2|Bacteria,2IXRR@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_457707_0	595460.RRSWK_04461	2.298e-69	247.0	COG0673@1|root,COG0673@2|Bacteria,2IXRR@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_457707_4	682795.AciX8_4612	3.263e-12	75.0	COG2929@1|root,COG2929@2|Bacteria,3Y5WV@57723|Acidobacteria	57723|Acidobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
TLS2_k127_457707_5	1195236.CTER_2873	4.924e-10	68.0	2DMWI@1|root,32U4D@2|Bacteria,1VKM3@1239|Firmicutes,25365@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_457707_1	244582.JQAK01000002_gene550	8.557e-51	184.0	COG1961@1|root,COG1961@2|Bacteria,1RBKN@1224|Proteobacteria,2U6XS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_7,Resolvase
TLS2_k127_4577282_5	234267.Acid_5644	4.978e-36	138.0	COG1146@1|root,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
TLS2_k127_4577282_1	1340493.JNIF01000003_gene4432	3.398e-88	306.0	COG3618@1|root,COG3618@2|Bacteria,3Y4BB@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase	-	-	-	ko:K07046	ko00051,ko01120,map00051,map01120	-	R10689	RC00537	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
TLS2_k127_4577282_0	1340493.JNIF01000003_gene3658	5.621e-97	330.0	COG1240@1|root,COG1240@2|Bacteria,3Y474@57723|Acidobacteria	57723|Acidobacteria	H	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
TLS2_k127_4577282_3	234267.Acid_1403	1.183e-49	182.0	COG0521@1|root,COG0521@2|Bacteria,3Y504@57723|Acidobacteria	57723|Acidobacteria	H	TIGRFAM molybdenum cofactor synthesis	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
TLS2_k127_4577282_2	234267.Acid_1404	6.522e-60	211.0	COG0315@1|root,COG0315@2|Bacteria,3Y4IY@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
TLS2_k127_4577596_1	869210.Marky_1927	2.408e-136	442.0	COG0076@1|root,COG0076@2|Bacteria,1WKXN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	COG0076 Glutamate decarboxylase and related PLP-dependent	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS2_k127_4577596_2	1267535.KB906767_gene2380	3.049e-131	425.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS2_k127_4577596_3	1340493.JNIF01000004_gene404	1.82e-118	394.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C,TAT_signal
TLS2_k127_4577596_0	589865.DaAHT2_1644	1.964e-231	735.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42P3J@68525|delta/epsilon subdivisions,2WKFS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS2_k127_4577596_4	1122223.KB890687_gene2436	6.68e-74	252.0	COG0225@1|root,COG0225@2|Bacteria,1WK2Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS2_k127_4577596_6	234267.Acid_5564	1.966e-36	147.0	COG2968@1|root,COG2968@2|Bacteria,3Y844@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
TLS2_k127_4577596_5	234267.Acid_4487	1.992e-45	168.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_4594236_2	1340493.JNIF01000003_gene2936	4.18e-91	301.0	COG1012@1|root,COG1012@2|Bacteria,3Y3V5@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.28	ko:K00141,ko:K22187	ko00040,ko00622,ko00623,ko00627,ko01100,ko01120,ko01220,map00040,map00622,map00623,map00627,map01100,map01120,map01220	M00537,M00538	R01293,R01419,R05289,R05663,R05664,R07667,R11768	RC00075,RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_4594236_1	234267.Acid_6389	4.74e-102	362.0	COG4403@1|root,COG4403@2|Bacteria	2|Bacteria	V	Lanthionine synthetase C family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4135,LANC_like,VCBS
TLS2_k127_4594236_5	56107.Cylst_5525	1.862e-55	208.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_4594236_0	204669.Acid345_4155	3.62e-138	475.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria,2JIZ4@204432|Acidobacteriia	204432|Acidobacteriia	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_4594236_3	251221.35211147	5.006e-84	312.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1G1EB@1117|Cyanobacteria	1117|Cyanobacteria	KLT	serine threonine protein kinase	-	-	2.7.1.37,2.7.11.1	ko:K00870,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FHA,Pkinase,TPR_11,TPR_16,TPR_8
TLS2_k127_4594236_4	1340493.JNIF01000003_gene2146	1.568e-73	252.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_4599700_0	234267.Acid_4760	2.968e-213	671.0	COG0249@1|root,COG0249@2|Bacteria,3Y2J5@57723|Acidobacteria	57723|Acidobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
TLS2_k127_4599700_4	234267.Acid_4759	2.59e-127	418.0	COG2377@1|root,COG2377@2|Bacteria,3Y3CU@57723|Acidobacteria	57723|Acidobacteria	O	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
TLS2_k127_4599700_2	1121904.ARBP01000032_gene2003	5.8e-138	454.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,EcsC
TLS2_k127_4599700_10	1123023.JIAI01000001_gene6793	1.01e-24	106.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	ynjA	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_4599700_12	44454.NF84_19740	8.191e-05	48.0	COG2128@1|root,COG2128@2|Bacteria,2I829@201174|Actinobacteria,23511@1762|Mycobacteriaceae	201174|Actinobacteria	L	carboxymuconolactone decarboxylase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	CMD
TLS2_k127_4599700_3	861299.J421_1078	5.422e-128	417.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	ramA	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS2_k127_4599700_11	1121864.OMO_00162	8.21e-06	58.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,4HA22@91061|Bacilli,4B080@81852|Enterococcaceae	91061|Bacilli	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TLS2_k127_4599700_5	1340493.JNIF01000004_gene995	1.108e-97	324.0	COG1028@1|root,COG1028@2|Bacteria,3Y7U3@57723|Acidobacteria	57723|Acidobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_4599700_9	1123367.C666_00115	1.869e-29	131.0	COG5652@1|root,COG5652@2|Bacteria,1R5TU@1224|Proteobacteria,2VVM2@28216|Betaproteobacteria	28216|Betaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
TLS2_k127_4599700_7	234267.Acid_3868	1.753e-60	217.0	COG0053@1|root,COG0053@2|Bacteria,3Y5VF@57723|Acidobacteria	57723|Acidobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
TLS2_k127_4599700_8	1121920.AUAU01000004_gene877	1.245e-30	126.0	COG4309@1|root,COG4309@2|Bacteria,3Y8N7@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF1858)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
TLS2_k127_4599700_1	234267.Acid_2924	2.588e-163	524.0	COG2461@1|root,COG2461@2|Bacteria,3Y7BF@57723|Acidobacteria	57723|Acidobacteria	S	Family of unknown function (DUF438)	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF438,Hemerythrin,PAS_10
TLS2_k127_460247_3	234267.Acid_5623	1.19e-63	222.0	COG4948@1|root,COG4948@2|Bacteria,3Y6CG@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Mandelate racemase muconate lactonizing enzyme, N-terminal domain protein	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_460247_0	234267.Acid_0592	8.309e-159	507.0	COG0492@1|root,COG0492@2|Bacteria,3Y2W6@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_460247_1	880070.Cycma_2350	2.341e-90	313.0	COG3119@1|root,COG3119@2|Bacteria,4NE7S@976|Bacteroidetes	976|Bacteroidetes	P	COG COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_460247_2	234267.Acid_5340	3.628e-75	268.0	COG0577@1|root,COG0577@2|Bacteria,3Y4J3@57723|Acidobacteria	57723|Acidobacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4607141_4	1547437.LL06_04015	1.848e-13	79.0	COG0388@1|root,COG0388@2|Bacteria,1RJE6@1224|Proteobacteria,2UDTM@28211|Alphaproteobacteria,43MR4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS2_k127_4607141_3	1340493.JNIF01000003_gene3393	3.247e-51	193.0	COG4959@1|root,COG4959@2|Bacteria	2|Bacteria	OU	Type IV secretory pathway protease TraF	traF	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S26
TLS2_k127_4607141_1	1340493.JNIF01000003_gene3347	1.459e-58	206.0	COG0629@1|root,COG0629@2|Bacteria	2|Bacteria	L	single-stranded DNA binding	ssbB	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_4607141_0	1340493.JNIF01000003_gene3348	0.0	1009.0	COG3505@1|root,COG3505@2|Bacteria	2|Bacteria	U	unidirectional conjugation	traG	-	-	ko:K03205	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	T4SS-DNA_transf
TLS2_k127_4607141_2	1340493.JNIF01000003_gene3349	1.518e-58	209.0	COG4227@1|root,COG4227@2|Bacteria,3Y6Y0@57723|Acidobacteria	57723|Acidobacteria	L	Domain of unknown function (DUF1738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1738
TLS2_k127_4608278_2	234267.Acid_7543	4.632e-123	401.0	COG0823@1|root,COG0823@2|Bacteria,3Y6DB@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
TLS2_k127_4608278_0	234267.Acid_1645	3.244e-210	664.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria	57723|Acidobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_4608278_1	1267535.KB906767_gene4229	8.91e-147	471.0	COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,3Y3X4@57723|Acidobacteria,2JING@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,HisKA_7TM,PAS,PAS_4
TLS2_k127_4609214_2	1267535.KB906767_gene1429	1.156e-25	109.0	2DEX9@1|root,2ZPM7@2|Bacteria	2|Bacteria	S	Vitamin K epoxide reductase family	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
TLS2_k127_4609214_0	1232410.KI421418_gene2241	2.223e-90	306.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,42NDF@68525|delta/epsilon subdivisions,2WJPS@28221|Deltaproteobacteria,43TE5@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS2_k127_4609214_4	795359.TOPB45_1024	4.459e-16	80.0	COG2823@1|root,COG2823@2|Bacteria,2GHZQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	bacterial OsmY and nodulation domain	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
TLS2_k127_4609214_3	1144319.PMI16_04900	1.348e-20	99.0	2B41E@1|root,31WRS@2|Bacteria,1P8VA@1224|Proteobacteria,2VSE9@28216|Betaproteobacteria,47506@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4609214_1	1340493.JNIF01000004_gene141	8.005e-80	273.0	COG3861@1|root,COG3861@2|Bacteria	2|Bacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	PRC
TLS2_k127_4609214_5	247490.KSU1_C1033	4.998e-16	82.0	COG2823@1|root,COG2823@2|Bacteria,2J1BI@203682|Planctomycetes	203682|Planctomycetes	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS2_k127_461286_2	234267.Acid_2214	3.74e-84	302.0	COG0577@1|root,COG0577@2|Bacteria,3Y6B8@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_461286_6	888060.HMPREF9081_0175	1.739e-05	54.0	COG0129@1|root,COG0129@2|Bacteria,1U56J@1239|Firmicutes,4H3K6@909932|Negativicutes	909932|Negativicutes	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82	ko:K22396	ko00040,map00040	-	R02429	RC00543	ko00000,ko00001,ko01000	-	-	-	ILVD_EDD
TLS2_k127_461286_5	1038859.AXAU01000002_gene660	1.339e-24	118.0	COG0535@1|root,COG0535@2|Bacteria,1NJZV@1224|Proteobacteria,2U4H8@28211|Alphaproteobacteria,3JXW2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
TLS2_k127_461286_0	1267535.KB906767_gene4130	2.849e-159	510.0	COG2133@1|root,COG2133@2|Bacteria,3Y6W0@57723|Acidobacteria	57723|Acidobacteria	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,VCBS
TLS2_k127_461286_4	1122185.N792_09025	8.447e-25	106.0	COG1544@1|root,COG1544@2|Bacteria,1N9T3@1224|Proteobacteria,1SDXP@1236|Gammaproteobacteria,1X959@135614|Xanthomonadales	135614|Xanthomonadales	J	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S30AE
TLS2_k127_461286_1	1267535.KB906767_gene5245	3.26e-142	493.0	COG1629@1|root,COG4771@2|Bacteria,3Y2R5@57723|Acidobacteria,2JIK7@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_461286_3	443143.GM18_0341	1.055e-59	211.0	COG2133@1|root,COG2133@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_461523_8	234267.Acid_2426	3.755e-68	239.0	COG5588@1|root,COG5588@2|Bacteria,3Y7RN@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
TLS2_k127_461523_7	1340493.JNIF01000003_gene2611	9.345e-74	258.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_461523_2	234267.Acid_3432	1.765e-171	554.0	COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4DC@57723|Acidobacteria	57723|Acidobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF_3,SpoIIE
TLS2_k127_461523_0	338966.Ppro_3226	2.673e-299	944.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,43S1D@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpF	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS2_k127_461523_3	234267.Acid_2796	7.883e-164	527.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
TLS2_k127_461523_5	1340493.JNIF01000004_gene337	1.868e-129	425.0	COG1181@1|root,COG1181@2|Bacteria,3Y3HW@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TLS2_k127_461523_4	1267535.KB906767_gene5022	2.541e-131	425.0	COG0010@1|root,COG0010@2|Bacteria,3Y46E@57723|Acidobacteria,2JIPY@204432|Acidobacteriia	204432|Acidobacteriia	E	Arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS2_k127_461523_1	1267535.KB906767_gene5021	1.757e-241	751.0	COG0017@1|root,COG0017@2|Bacteria,3Y350@57723|Acidobacteria,2JI7K@204432|Acidobacteriia	204432|Acidobacteriia	J	class II (D K	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
TLS2_k127_461523_6	234267.Acid_2806	5.989e-109	361.0	COG1082@1|root,COG1082@2|Bacteria,3Y4EN@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_461523_9	382464.ABSI01000006_gene798	6.782e-42	155.0	COG4146@1|root,COG4146@2|Bacteria,46UV3@74201|Verrucomicrobia,2ITNB@203494|Verrucomicrobiae	2|Bacteria	S	Sodium:solute symporter family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
TLS2_k127_462650_2	1340493.JNIF01000003_gene1887	1.557e-42	158.0	COG0673@1|root,COG0673@2|Bacteria,3Y6C9@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_462650_4	301.JNHE01000012_gene1383	5.328e-28	117.0	COG3011@1|root,COG3011@2|Bacteria,1N0YV@1224|Proteobacteria,1S7AJ@1236|Gammaproteobacteria,1YG83@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
TLS2_k127_462650_0	391612.CY0110_22182	7.216e-54	206.0	2BT73@1|root,32H5W@2|Bacteria,1GHM6@1117|Cyanobacteria,3KK5G@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_462650_1	1142394.PSMK_19660	7.336e-45	177.0	2DSQ9@1|root,33H15@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_462650_3	234267.Acid_1154	4.01e-39	153.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_4627236_0	234267.Acid_2792	9.273e-54	208.0	COG2202@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,3Y4XJ@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_9
TLS2_k127_4629174_0	204669.Acid345_1810	4.321e-175	557.0	COG0674@1|root,COG0674@2|Bacteria,3Y3NX@57723|Acidobacteria,2JKIA@204432|Acidobacteriia	2|Bacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
TLS2_k127_4629174_3	234267.Acid_6987	7.477e-39	147.0	COG1146@1|root,COG1146@2|Bacteria,3Y8H9@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S binding domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
TLS2_k127_4629174_1	234267.Acid_1025	1.055e-99	339.0	COG0738@1|root,COG0738@2|Bacteria,3Y6YP@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4629174_4	234267.Acid_4211	7.938e-32	138.0	2DFMP@1|root,2ZSBB@2|Bacteria,3Y8UP@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4629174_2	234267.Acid_1026	3.206e-88	301.0	COG2027@1|root,COG2027@2|Bacteria,3Y3WF@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
TLS2_k127_4630632_1	1380600.AUYN01000009_gene1077	9.874e-65	226.0	COG2133@1|root,COG2133@2|Bacteria,4NF61@976|Bacteroidetes	976|Bacteroidetes	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
TLS2_k127_4630632_0	215803.DB30_8370	3.104e-98	342.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,433ZM@68525|delta/epsilon subdivisions,2X48T@28221|Deltaproteobacteria,2YYI5@29|Myxococcales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_4631475_0	1403819.BATR01000195_gene6595	1.122e-121	410.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TLS2_k127_4631475_1	28072.Nos7524_5414	9.512e-53	198.0	COG1216@1|root,COG1216@2|Bacteria,1G3T8@1117|Cyanobacteria,1HNFR@1161|Nostocales	1117|Cyanobacteria	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
TLS2_k127_4638231_1	234267.Acid_5744	2.31e-10	64.0	COG2304@1|root,COG2304@2|Bacteria,3Y6TM@57723|Acidobacteria	57723|Acidobacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
TLS2_k127_4638231_0	234267.Acid_5743	3.124e-199	639.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,3Y6PH@57723|Acidobacteria	57723|Acidobacteria	S	Putative glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like,VWA
TLS2_k127_4649917_0	1340493.JNIF01000003_gene3748	3.767e-300	955.0	COG3485@1|root,COG3485@2|Bacteria,3Y3VM@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_4649917_4	234267.Acid_2841	1.603e-105	353.0	COG1476@1|root,COG1910@1|root,COG1476@2|Bacteria,COG1910@2|Bacteria	2|Bacteria	P	PBP superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,PBP_like
TLS2_k127_4649917_1	234267.Acid_5465	2.052e-233	750.0	COG0577@1|root,COG0577@2|Bacteria,3Y6MX@57723|Acidobacteria	2|Bacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_4649917_6	401053.AciPR4_2546	5.097e-37	143.0	COG1695@1|root,COG1695@2|Bacteria,3Y81G@57723|Acidobacteria,2JN0V@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_4649917_3	234267.Acid_4489	9.698e-150	507.0	COG0577@1|root,COG0577@2|Bacteria,3Y34I@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_4649917_5	234267.Acid_3245	6.074e-103	347.0	COG1082@1|root,COG1082@2|Bacteria,3Y73B@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_4649917_2	234267.Acid_3246	7.86e-202	637.0	COG0673@1|root,COG0673@2|Bacteria,3Y76D@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_4672702_1	1267535.KB906767_gene4302	8.996e-88	299.0	COG0617@1|root,COG0617@2|Bacteria,3Y3U6@57723|Acidobacteria,2JIF4@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the tRNA nucleotidyltransferase poly(A) polymerase family	-	-	-	-	-	-	-	-	-	-	-	-	PolyA_pol
TLS2_k127_4672702_0	234267.Acid_6406	2.743e-91	315.0	COG4974@1|root,COG4974@2|Bacteria,3Y3D0@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_4672702_6	234267.Acid_6405	9.561e-44	165.0	2C62N@1|root,32TCB@2|Bacteria,3Y55K@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4672702_3	1267535.KB906767_gene3931	1.204e-73	259.0	COG0639@1|root,COG0639@2|Bacteria,3Y3U2@57723|Acidobacteria,2JIPQ@204432|Acidobacteriia	204432|Acidobacteriia	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
TLS2_k127_4672702_2	234267.Acid_0954	2.213e-81	284.0	COG1408@1|root,COG1408@2|Bacteria,3Y5PS@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
TLS2_k127_4672702_4	1340493.JNIF01000003_gene3109	6.642e-72	244.0	COG2133@1|root,COG2133@2|Bacteria,3Y3YZ@57723|Acidobacteria	57723|Acidobacteria	G	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS2_k127_4677162_2	1267535.KB906767_gene1827	4.851e-117	415.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_4677162_0	234267.Acid_6547	5.412e-251	797.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_4677162_1	234267.Acid_6548	1.735e-151	488.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_4677739_3	234267.Acid_3339	2.313e-37	142.0	COG0079@1|root,COG0079@2|Bacteria,3Y3Q8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_4677739_0	234267.Acid_5786	8.219e-124	407.0	COG0265@1|root,COG0265@2|Bacteria,3Y2WB@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_4677739_4	1267535.KB906767_gene3901	1.142e-05	55.0	2DYK5@1|root,34A5U@2|Bacteria,3Y8GF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl_2
TLS2_k127_4677739_1	344747.PM8797T_05400	1.054e-92	321.0	COG1520@1|root,COG1520@2|Bacteria,2IY8V@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TLS2_k127_4677739_2	1078020.KEK_14563	9.935e-61	222.0	COG1656@1|root,COG1656@2|Bacteria,2GMQR@201174|Actinobacteria,23528@1762|Mycobacteriaceae	201174|Actinobacteria	S	Mut7-C ubiquitin	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
TLS2_k127_4680448_0	234267.Acid_3470	2.854e-69	251.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_4680448_3	667632.KB890175_gene4120	4.776e-07	58.0	COG3631@1|root,COG3631@2|Bacteria,1RM0Y@1224|Proteobacteria,2VTQT@28216|Betaproteobacteria,1K7GG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	ko:K07255	ko00430,map00430	-	R01685	RC00062	ko00000,ko00001,ko01000	-	-	-	SnoaL_2
TLS2_k127_4680448_1	1217720.ALOX01000176_gene1331	4.012e-44	165.0	COG5573@1|root,COG5573@2|Bacteria,1RKIK@1224|Proteobacteria,2VEQE@28211|Alphaproteobacteria	1224|Proteobacteria	S	Large family of predicted nucleotide-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_4680448_2	1335760.ASTG01000027_gene2110	1.809e-25	109.0	COG2336@1|root,COG2336@2|Bacteria	2|Bacteria	T	PFAM SpoVT AbrB	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
TLS2_k127_4685022_2	234267.Acid_7013	1.896e-108	362.0	COG1559@1|root,COG1559@2|Bacteria,3Y2RD@57723|Acidobacteria	57723|Acidobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
TLS2_k127_4685022_4	1267535.KB906767_gene1029	1.099e-45	169.0	COG0816@1|root,COG0816@2|Bacteria,3Y59A@57723|Acidobacteria,2JP2U@204432|Acidobacteriia	204432|Acidobacteriia	J	Likely ribonuclease with RNase H fold.	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
TLS2_k127_4685022_3	1267535.KB906767_gene246	2.722e-96	319.0	COG0605@1|root,COG0605@2|Bacteria,3Y2HD@57723|Acidobacteria,2JIMM@204432|Acidobacteriia	204432|Acidobacteriia	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
TLS2_k127_4685022_0	234267.Acid_1073	8.427e-225	706.0	COG0154@1|root,COG0154@2|Bacteria,3Y2PE@57723|Acidobacteria	57723|Acidobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_4685022_6	234267.Acid_1074	6.974e-35	136.0	COG0721@1|root,COG0721@2|Bacteria,3Y5QA@57723|Acidobacteria	57723|Acidobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
TLS2_k127_4685022_7	234267.Acid_1075	2.252e-32	134.0	COG5512@1|root,COG5512@2|Bacteria,3Y95D@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
TLS2_k127_4685022_5	234267.Acid_6612	7.616e-38	149.0	2BNC6@1|root,32GZV@2|Bacteria,3Y8TE@57723|Acidobacteria	57723|Acidobacteria	S	Gluconate 2-dehydrogenase subunit 3	-	-	1.1.99.3	ko:K06152	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	Gluconate_2-dh3
TLS2_k127_4685022_1	234267.Acid_6613	1.395e-200	635.0	COG2303@1|root,COG2303@2|Bacteria,3Y41Y@57723|Acidobacteria	57723|Acidobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_4686837_1	1382306.JNIM01000001_gene2807	3.771e-106	355.0	COG0554@1|root,COG0554@2|Bacteria,2G5TV@200795|Chloroflexi	2|Bacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK3	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS2_k127_4686837_0	1382306.JNIM01000001_gene2808	4.287e-139	448.0	COG3958@1|root,COG3958@2|Bacteria,2G8E1@200795|Chloroflexi	200795|Chloroflexi	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_4686837_2	1382306.JNIM01000001_gene2809	1.764e-99	328.0	COG3959@1|root,COG3959@2|Bacteria,2GA6J@200795|Chloroflexi	200795|Chloroflexi	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS2_k127_4694610_2	234267.Acid_0648	3.717e-103	338.0	COG1475@1|root,COG1475@2|Bacteria,3Y7ZH@57723|Acidobacteria	57723|Acidobacteria	K	ParB-like nuclease domain	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
TLS2_k127_4694610_1	1121007.AUML01000033_gene2818	9.61e-160	530.0	COG0463@1|root,COG4122@1|root,COG0463@2|Bacteria,COG4122@2|Bacteria,4PNJB@976|Bacteroidetes	976|Bacteroidetes	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_4694610_5	1198114.AciX9_2445	2.722e-21	111.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
TLS2_k127_4694610_0	1198114.AciX9_2446	3.151e-167	578.0	COG4447@1|root,COG4447@2|Bacteria,3Y4ZQ@57723|Acidobacteria,2JJE3@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4694610_3	1215092.PA6_046_00050	3.458e-55	198.0	COG3292@1|root,COG3292@2|Bacteria,1QMJ4@1224|Proteobacteria,1S1W2@1236|Gammaproteobacteria,1YJP6@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
TLS2_k127_4696527_2	1550091.JROE01000002_gene1131	2.618e-05	48.0	COG2312@1|root,COG2312@2|Bacteria,4NW00@976|Bacteroidetes,1ITY5@117747|Sphingobacteriia	976|Bacteroidetes	S	Erythromycin esterase	-	-	-	ko:K06880	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	CarbopepD_reg_2,Erythro_esteras
TLS2_k127_4696527_1	1346791.M529_07045	3.897e-19	96.0	2919Q@1|root,2ZNWS@2|Bacteria,1NAF5@1224|Proteobacteria,2U3AC@28211|Alphaproteobacteria,2KEWN@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4696527_0	1267533.KB906738_gene2351	1.238e-62	232.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS2_k127_4699346_4	450851.PHZ_c1594	4.649e-15	75.0	COG1878@1|root,COG1878@2|Bacteria,1R8IH@1224|Proteobacteria,2U9RH@28211|Alphaproteobacteria,2KIQF@204458|Caulobacterales	204458|Caulobacterales	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_4699346_3	344747.PM8797T_17397	6.873e-29	131.0	COG1482@1|root,COG1482@2|Bacteria,2IYEB@203682|Planctomycetes	203682|Planctomycetes	G	cell wall glycoprotein biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4699346_1	1340493.JNIF01000003_gene3768	2.15e-45	171.0	2CBEY@1|root,33YTG@2|Bacteria,3Y88I@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4699346_2	1267535.KB906767_gene5098	4.47e-41	157.0	2FGSP@1|root,348N1@2|Bacteria,3Y8G3@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4699346_0	1292034.OR37_01789	1.368e-80	286.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,2KK0Z@204458|Caulobacterales	204458|Caulobacterales	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
TLS2_k127_470932_1	401053.AciPR4_2699	1.138e-75	263.0	COG5029@1|root,COG5029@2|Bacteria	2|Bacteria	O	Prenyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
TLS2_k127_470932_0	886293.Sinac_5963	3.443e-135	449.0	COG3119@1|root,COG3119@2|Bacteria,2IX0S@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_470932_5	1032480.MLP_33800	1.148e-16	88.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	OapA,OapA_N,Peptidase_M23
TLS2_k127_470932_6	1120965.AUBV01000005_gene1691	1.02e-12	77.0	COG0739@1|root,COG1680@1|root,COG0739@2|Bacteria,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	tagE	-	2.7.7.6	ko:K03046,ko:K21471	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko03021,ko03400	-	-	-	OapA,OapA_N,Peptidase_M23,UT
TLS2_k127_470932_3	1385517.N800_12300	2.176e-32	132.0	COG0739@1|root,COG1680@1|root,COG0739@2|Bacteria,COG1680@2|Bacteria,1PI1J@1224|Proteobacteria,1TDYR@1236|Gammaproteobacteria,1XB7D@135614|Xanthomonadales	135614|Xanthomonadales	V	COG1680 Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_470932_4	401053.AciPR4_2893	6.356e-23	100.0	COG3547@1|root,COG3547@2|Bacteria,3Y5SI@57723|Acidobacteria,2JKWK@204432|Acidobacteriia	204432|Acidobacteriia	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_470932_2	401053.AciPR4_2893	1.444e-55	198.0	COG3547@1|root,COG3547@2|Bacteria,3Y5SI@57723|Acidobacteria,2JKWK@204432|Acidobacteriia	204432|Acidobacteriia	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_4713414_0	1267535.KB906767_gene884	0.0	1456.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria,2JI3C@204432|Acidobacteriia	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_4713414_1	1267535.KB906767_gene883	3.138e-60	211.0	COG1695@1|root,COG1695@2|Bacteria,3Y7XI@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_4719743_0	243090.RB11303	5.285e-82	290.0	COG3464@1|root,COG3464@2|Bacteria,2J105@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
TLS2_k127_4726014_3	1382359.JIAL01000001_gene2895	5.037e-58	203.0	COG4227@1|root,COG4227@2|Bacteria,3Y6Y0@57723|Acidobacteria	57723|Acidobacteria	L	Domain of unknown function (DUF1738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1738
TLS2_k127_4726014_2	1219045.BV98_002287	8.745e-151	489.0	COG4974@1|root,COG4974@2|Bacteria,1R72R@1224|Proteobacteria,2U27G@28211|Alphaproteobacteria,2K2UR@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_4726014_0	1219045.BV98_002286	9.22e-182	584.0	COG0582@1|root,COG0582@2|Bacteria,1NX90@1224|Proteobacteria,2U3EM@28211|Alphaproteobacteria,2K1HE@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_4726014_1	1112212.JH584238_gene3852	4.875e-159	513.0	COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2U0B6@28211|Alphaproteobacteria,2K1EE@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_4726014_4	1123250.KB908391_gene290	1.034e-07	55.0	COG4227@1|root,COG4227@2|Bacteria,1UY3K@1239|Firmicutes,4H3T5@909932|Negativicutes	909932|Negativicutes	L	Domain of unknown function (DUF1738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1738,YodL
TLS2_k127_4728139_0	1340493.JNIF01000003_gene3830	9.604e-312	975.0	COG1629@1|root,COG1629@2|Bacteria,3Y2ZU@57723|Acidobacteria	57723|Acidobacteria	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_4728139_1	234267.Acid_6646	3.321e-167	530.0	COG0641@1|root,COG0641@2|Bacteria,3Y8KB@57723|Acidobacteria	57723|Acidobacteria	C	Radical SAM superfamily	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Radical_SAM,SPASM
TLS2_k127_4731815_0	935863.AWZR01000006_gene1396	9.303e-236	734.0	COG3507@1|root,COG3507@2|Bacteria,1NNX4@1224|Proteobacteria,1RYTM@1236|Gammaproteobacteria,1X3YP@135614|Xanthomonadales	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_43
TLS2_k127_4731815_1	1384054.N790_01975	2.938e-21	94.0	COG1228@1|root,COG1228@2|Bacteria,1MXQX@1224|Proteobacteria,1RQGS@1236|Gammaproteobacteria,1X35X@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
TLS2_k127_4734390_6	926566.Terro_1590	7.345e-100	336.0	COG0463@1|root,COG2246@1|root,COG0463@2|Bacteria,COG2246@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	dpm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
TLS2_k127_4734390_5	330214.NIDE3701	5.242e-122	400.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
TLS2_k127_4734390_4	234267.Acid_1208	1.811e-146	494.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,TPR_8
TLS2_k127_4734390_2	234267.Acid_4166	1.132e-168	536.0	COG0079@1|root,COG0079@2|Bacteria,3Y4H9@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_4734390_11	1340493.JNIF01000004_gene262	2.765e-26	116.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,Copper-bind,Cytochrom_C,Cytochrome_CBB3,DUF1573,Laminin_G_3,ThuA
TLS2_k127_4734390_1	143224.JQMD01000002_gene1234	7.16e-176	568.0	COG3119@1|root,COG3119@2|Bacteria,4NEBN@976|Bacteroidetes,1HZSK@117743|Flavobacteriia	976|Bacteroidetes	P	sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
TLS2_k127_4734390_8	1267535.KB906767_gene4156	3.113e-75	257.0	COG0461@1|root,COG0461@2|Bacteria,3Y6JQ@57723|Acidobacteria	57723|Acidobacteria	F	Phosphoribosyl transferase domain	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
TLS2_k127_4734390_0	234267.Acid_7288	3.699e-192	610.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,3Y4NX@57723|Acidobacteria	57723|Acidobacteria	GM	CoA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS2_k127_4734390_9	1267535.KB906767_gene255	2.825e-66	231.0	COG0671@1|root,COG0671@2|Bacteria,3Y5XF@57723|Acidobacteria	57723|Acidobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
TLS2_k127_4734390_10	1121438.JNJA01000003_gene2831	2.978e-28	125.0	COG0438@1|root,COG0613@1|root,COG0438@2|Bacteria,COG0613@2|Bacteria,1MUB7@1224|Proteobacteria,42N14@68525|delta/epsilon subdivisions,2WIKT@28221|Deltaproteobacteria,2M8E0@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_4734390_3	1267535.KB906767_gene1449	1.273e-155	499.0	COG0707@1|root,COG0707@2|Bacteria,3Y651@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 28 C-terminal domain	-	-	2.4.1.46	ko:K03715	ko00561,ko01100,map00561,map01100	-	R02691	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C
TLS2_k127_4734390_7	234267.Acid_4460	1.139e-82	280.0	COG0659@1|root,COG0659@2|Bacteria,3Y3QP@57723|Acidobacteria	2|Bacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	Sulfate_transp
TLS2_k127_4737450_0	344747.PM8797T_14594	2.704e-160	516.0	COG3119@1|root,COG3119@2|Bacteria,2IYRK@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_4737450_1	395019.Bmul_3499	2.55e-91	317.0	COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,2VI5S@28216|Betaproteobacteria,1K3VK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM type III effector Hrp-dependent outers	hop	-	2.7.1.217	ko:K21948	-	-	R11706,R11707	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
TLS2_k127_4737450_2	1340493.JNIF01000004_gene448	2.493e-44	166.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3IB@57723|Acidobacteria	57723|Acidobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_4741837_2	330214.NIDE2536	1.938e-106	350.0	COG0021@1|root,COG0021@2|Bacteria,3J0MM@40117|Nitrospirae	40117|Nitrospirae	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TLS2_k127_4741837_6	926566.Terro_0551	3.904e-11	68.0	2CTSB@1|root,32SU2@2|Bacteria,3Y567@57723|Acidobacteria,2JJPT@204432|Acidobacteriia	204432|Acidobacteriia	S	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_4741837_0	1267535.KB906767_gene4151	3.488e-269	839.0	COG0028@1|root,COG0028@2|Bacteria,3Y3QI@57723|Acidobacteria,2JITT@204432|Acidobacteriia	204432|Acidobacteriia	EH	Belongs to the TPP enzyme family	-	-	1.2.5.1	ko:K00156	ko00620,map00620	-	R03145	RC00860	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_4741837_1	713587.THITH_11275	8.604e-243	764.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,1RS4U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Glucoamylase and related glycosyl hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
TLS2_k127_4741837_5	861299.J421_1787	7.585e-30	124.0	COG3474@1|root,COG3474@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	1.9.3.1	ko:K02275,ko:K02305,ko:K08738,ko:K17223	ko00190,ko00910,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00910,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00155,M00529,M00595	R00081,R00294,R10151	RC00016,RC02794,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.10,3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
TLS2_k127_4741837_3	1504672.669784460	5.925e-50	194.0	COG2010@1|root,COG2010@2|Bacteria,1MW1W@1224|Proteobacteria,2VQSF@28216|Betaproteobacteria,4AGS6@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
TLS2_k127_4741837_4	1267535.KB906767_gene4678	2.566e-43	160.0	COG1092@1|root,COG1092@2|Bacteria,3Y2PV@57723|Acidobacteria,2JICM@204432|Acidobacteriia	204432|Acidobacteriia	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TLS2_k127_4742598_2	644282.Deba_2916	5.449e-82	280.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS2_k127_4742598_6	1304284.L21TH_0916	7.364e-16	80.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,24MQE@186801|Clostridia,36KM7@31979|Clostridiaceae	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
TLS2_k127_4742598_7	234267.Acid_5094	1.175e-15	77.0	COG0257@1|root,COG0257@2|Bacteria,3Y5X6@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
TLS2_k127_4742598_4	1267535.KB906767_gene2681	7.65e-60	209.0	COG0099@1|root,COG0099@2|Bacteria,3Y4KC@57723|Acidobacteria,2JJAF@204432|Acidobacteriia	204432|Acidobacteriia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
TLS2_k127_4742598_3	1267535.KB906767_gene2680	2.27e-66	228.0	COG0100@1|root,COG0100@2|Bacteria,3Y4BS@57723|Acidobacteria,2JJ4Q@204432|Acidobacteriia	204432|Acidobacteriia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
TLS2_k127_4742598_1	1267535.KB906767_gene2679	4.036e-95	315.0	COG0522@1|root,COG0522@2|Bacteria,3Y2I1@57723|Acidobacteria,2JHR6@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
TLS2_k127_4742598_0	1267535.KB906767_gene2678	6.335e-180	567.0	COG0202@1|root,COG0202@2|Bacteria,3Y3HK@57723|Acidobacteria,2JHZ6@204432|Acidobacteriia	204432|Acidobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
TLS2_k127_4742598_5	234267.Acid_5089	1.45e-57	203.0	COG0203@1|root,COG0203@2|Bacteria,3Y4JF@57723|Acidobacteria	57723|Acidobacteria	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
TLS2_k127_4742598_8	1121861.KB899920_gene2833	1.062e-07	60.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2TQUJ@28211|Alphaproteobacteria,2JV0G@204441|Rhodospirillales	1224|Proteobacteria	G	Domain of unknown function (DUF3459)	-	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TLS2_k127_4746412_2	479434.Sthe_0108	0.0003703	43.0	COG2159@1|root,COG2159@2|Bacteria,2G8UX@200795|Chloroflexi,27Z57@189775|Thermomicrobia	189775|Thermomicrobia	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
TLS2_k127_4746412_1	2903.EOD20660	5.537e-05	56.0	KOG2177@1|root,KOG2177@2759|Eukaryota	2759|Eukaryota	O	zinc ion binding	-	-	2.3.2.27	ko:K12035	ko05206,map05206	-	-	-	ko00000,ko00001,ko01000,ko03019,ko04121	-	-	-	NHL
TLS2_k127_4746412_0	861299.J421_1476	4.156e-48	176.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
TLS2_k127_4758039_0	234267.Acid_1400	8.821e-218	679.0	COG0422@1|root,COG0422@2|Bacteria,3Y2TX@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
TLS2_k127_4758039_1	234267.Acid_0911	1.18e-86	300.0	COG4775@1|root,COG4775@2|Bacteria,3Y7I1@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Surface antigen variable number	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	POTRA
TLS2_k127_4761_3	234267.Acid_7439	5.277e-58	202.0	COG1215@1|root,COG1215@2|Bacteria,3Y5K6@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_4761_1	234267.Acid_7440	1.709e-73	259.0	COG1216@1|root,COG1216@2|Bacteria,3Y80R@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_4761_2	1267535.KB906767_gene3848	6.981e-67	239.0	COG1216@1|root,COG1216@2|Bacteria,3Y7JI@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
TLS2_k127_4761_0	234267.Acid_7442	4.599e-136	437.0	COG1216@1|root,COG1216@2|Bacteria,3Y7CJ@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_4773132_0	234267.Acid_6854	1.401e-167	553.0	COG1629@1|root,COG4771@2|Bacteria,3Y477@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_4773132_5	284031.JNXD01000003_gene3852	7.104e-07	57.0	COG4319@1|root,COG4319@2|Bacteria,2IMG5@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_4773132_4	204669.Acid345_3993	6.492e-22	108.0	COG2304@1|root,COG2304@2|Bacteria,3Y44P@57723|Acidobacteria,2JIT1@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM VWFA-related Acidobacterial domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_4773132_1	448385.sce5416	2.412e-91	315.0	COG1858@1|root,COG1858@2|Bacteria,1QTHX@1224|Proteobacteria,43F3A@68525|delta/epsilon subdivisions,2WZD5@28221|Deltaproteobacteria,2YUR6@29|Myxococcales	28221|Deltaproteobacteria	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG
TLS2_k127_4773132_2	234267.Acid_7797	6.172e-38	152.0	2E8G8@1|root,332UI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
TLS2_k127_4773132_3	234267.Acid_0525	1.52e-24	106.0	COG4798@1|root,COG4798@2|Bacteria	2|Bacteria	E	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,FAD_binding_4,Methyltransf_11,Methyltransf_25,Methyltransf_31,SAM_MT
TLS2_k127_4780970_0	1267535.KB906767_gene2488	8.625e-179	569.0	COG0557@1|root,COG0557@2|Bacteria,3Y3TF@57723|Acidobacteria,2JIM3@204432|Acidobacteriia	204432|Acidobacteriia	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
TLS2_k127_4780970_1	379066.GAU_2793	5.469e-112	369.0	COG2321@1|root,COG2321@2|Bacteria,1ZSN1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
TLS2_k127_4780970_2	1163617.SCD_n02419	1.068e-10	70.0	COG3064@1|root,COG3064@2|Bacteria,1P2CR@1224|Proteobacteria	1224|Proteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4781583_1	706587.Desti_2130	1.525e-23	102.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,43AV8@68525|delta/epsilon subdivisions,2X69B@28221|Deltaproteobacteria,2MSKC@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_4781583_2	234267.Acid_0129	1.101e-05	53.0	COG0745@1|root,COG0745@2|Bacteria	234267.Acid_0129|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4781583_0	1403819.BATR01000195_gene6595	3.163e-107	363.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TLS2_k127_4796044_1	671143.DAMO_1604	7.842e-49	178.0	COG1143@1|root,COG1143@2|Bacteria,2NPQR@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.5.3	ko:K00337,ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3153	Fer4
TLS2_k127_4796044_0	204669.Acid345_4032	6.075e-54	200.0	COG2972@1|root,COG2972@2|Bacteria,3Y3NH@57723|Acidobacteria,2JHT4@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	5TM-5TMR_LYT,HATPase_c,His_kinase
TLS2_k127_4800067_2	682795.AciX8_0865	2.173e-50	191.0	COG1629@1|root,COG4771@2|Bacteria,3Y4C9@57723|Acidobacteria,2JMK8@204432|Acidobacteriia	204432|Acidobacteriia	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_4800067_0	1163408.UU9_00685	5.179e-108	362.0	COG0673@1|root,COG0673@2|Bacteria,1MVVF@1224|Proteobacteria,1RMKA@1236|Gammaproteobacteria,1X60T@135614|Xanthomonadales	135614|Xanthomonadales	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4800067_1	1123274.KB899406_gene1237	2.456e-78	271.0	COG1063@1|root,COG1063@2|Bacteria,2J6S3@203691|Spirochaetes	203691|Spirochaetes	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_4805899_2	1123389.ATXJ01000032_gene1671	2.557e-06	51.0	COG4118@1|root,COG4118@2|Bacteria,1WKUE@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS2_k127_4805899_0	1041146.ATZB01000035_gene632	3.846e-53	191.0	COG2184@1|root,COG2184@2|Bacteria,1RAVF@1224|Proteobacteria,2U59F@28211|Alphaproteobacteria,4BB92@82115|Rhizobiaceae	28211|Alphaproteobacteria	D	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
TLS2_k127_4805899_1	366602.Caul_5363	1.637e-16	82.0	COG1396@1|root,COG1396@2|Bacteria,1N3BI@1224|Proteobacteria,2UC1D@28211|Alphaproteobacteria,2KJB8@204458|Caulobacterales	204458|Caulobacterales	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS2_k127_4807491_1	234267.Acid_7764	5.19e-115	379.0	COG0673@1|root,COG0673@2|Bacteria,3Y4BF@57723|Acidobacteria	57723|Acidobacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_4807491_0	886293.Sinac_6095	1.007e-182	595.0	COG1073@1|root,COG1073@2|Bacteria,2IYEI@203682|Planctomycetes	203682|Planctomycetes	Q	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS2_k127_4807491_2	234267.Acid_4451	8.68e-91	318.0	COG0673@1|root,COG0673@2|Bacteria,3Y71T@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4807491_3	1267534.KB906754_gene3626	3.141e-06	53.0	COG0583@1|root,COG0583@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
TLS2_k127_4810069_1	1340493.JNIF01000003_gene1412	1.996e-67	233.0	COG1131@1|root,COG1131@2|Bacteria,3Y4CW@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4810069_0	234267.Acid_0080	1.621e-82	282.0	COG0842@1|root,COG1228@1|root,COG0842@2|Bacteria,COG1228@2|Bacteria,3Y750@57723|Acidobacteria	57723|Acidobacteria	QV	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,Amidohydro_1
TLS2_k127_4810069_5	1250232.JQNJ01000001_gene1031	1.822e-08	64.0	COG2318@1|root,COG2318@2|Bacteria,4NNW4@976|Bacteroidetes,1I28C@117743|Flavobacteriia	976|Bacteroidetes	J	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_4810069_3	78245.Xaut_0312	2.208e-34	136.0	COG0702@1|root,COG0702@2|Bacteria,1MW44@1224|Proteobacteria,2TT9D@28211|Alphaproteobacteria,3EXYN@335928|Xanthobacteraceae	28211|Alphaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
TLS2_k127_4811864_1	243231.GSU1300	7.739e-101	347.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,43STW@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	histidine kinase HAMP region domain protein	mcp34H-6	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,CZB,HAMP,MCPsignal,dCache_1
TLS2_k127_4811864_6	909663.KI867150_gene362	1.139e-53	193.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42SH0@68525|delta/epsilon subdivisions,2WPFU@28221|Deltaproteobacteria,2MS7I@213462|Syntrophobacterales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
TLS2_k127_4811864_3	941449.dsx2_1857	2.114e-77	271.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42MR2@68525|delta/epsilon subdivisions,2WKKH@28221|Deltaproteobacteria,2M8R1@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	cheR-1	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N,Response_reg
TLS2_k127_4811864_0	573370.DMR_23750	1.486e-158	506.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,2M8VE@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB34H	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
TLS2_k127_4811864_8	886293.Sinac_3180	9.408e-45	179.0	COG0671@1|root,COG0671@2|Bacteria,2J3BG@203682|Planctomycetes	203682|Planctomycetes	I	phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4811864_7	211114.JOEF01000025_gene185	1.518e-52	207.0	COG0491@1|root,COG0491@2|Bacteria,2IBAX@201174|Actinobacteria	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_4811864_4	1340493.JNIF01000003_gene1514	4.896e-76	276.0	COG3485@1|root,COG3485@2|Bacteria,3Y9A8@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_4811864_2	1267535.KB906767_gene5039	2.972e-98	327.0	COG0520@1|root,COG0520@2|Bacteria,3Y632@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_4816667_8	1089544.KB912942_gene7794	1.725e-13	72.0	COG0473@1|root,COG0473@2|Bacteria,2GK44@201174|Actinobacteria,4DZTN@85010|Pseudonocardiales	201174|Actinobacteria	CE	Tartrate dehydrogenase	dmlA	-	1.1.1.83,1.1.1.93,4.1.1.73	ko:K07246	ko00630,ko00650,map00630,map00650	-	R00215,R01751,R02545,R06180	RC00084,RC00105,RC00594	ko00000,ko00001,ko01000	-	-	-	Iso_dh
TLS2_k127_4816667_7	572478.Vdis_0554	3.754e-52	197.0	arCOG06505@1|root,arCOG06505@2157|Archaea,2XRQB@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4816667_0	1340493.JNIF01000003_gene3558	2.203e-280	874.0	COG1164@1|root,COG1164@2|Bacteria,3Y2SB@57723|Acidobacteria	57723|Acidobacteria	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
TLS2_k127_4816667_5	1168059.KB899087_gene2399	3.088e-86	301.0	COG4325@1|root,COG4325@2|Bacteria,1MXTM@1224|Proteobacteria,2TRWI@28211|Alphaproteobacteria,3F1ZF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
TLS2_k127_4816667_1	1340493.JNIF01000003_gene3916	5.873e-149	479.0	COG2006@1|root,COG2006@2|Bacteria,3Y6M1@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
TLS2_k127_4816667_6	1210884.HG799465_gene11943	7.019e-58	207.0	COG2010@1|root,COG2010@2|Bacteria,2J4WG@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_4816667_2	886293.Sinac_2838	3.031e-146	484.0	COG0673@1|root,COG0673@2|Bacteria,2IY5Y@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4816667_3	234267.Acid_3974	1.497e-126	411.0	COG1606@1|root,COG1606@2|Bacteria,3Y30C@57723|Acidobacteria	57723|Acidobacteria	L	tRNA processing	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	NAD_synthase
TLS2_k127_4816667_4	575540.Isop_3370	4.58e-90	302.0	COG3386@1|root,COG3386@2|Bacteria,2J2MK@203682|Planctomycetes	203682|Planctomycetes	G	BNR repeat-containing family member	-	-	-	-	-	-	-	-	-	-	-	-	BNR_4
TLS2_k127_4826377_0	886293.Sinac_7009	1.402e-282	879.0	COG2010@1|root,COG2010@2|Bacteria,2IY6K@203682|Planctomycetes	203682|Planctomycetes	C	Protein of unknown function (DUF1549)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_4834482_4	518766.Rmar_1790	1.535e-98	336.0	COG1228@1|root,COG1228@2|Bacteria,4NEV0@976|Bacteroidetes	976|Bacteroidetes	Q	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_4834482_8	1121104.AQXH01000004_gene63	4.79e-12	67.0	COG1228@1|root,COG1228@2|Bacteria,4NEV0@976|Bacteroidetes,1IWPE@117747|Sphingobacteriia	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_4834482_0	639030.JHVA01000001_gene1797	2.025e-277	891.0	COG1629@1|root,COG1629@2|Bacteria,3Y39E@57723|Acidobacteria,2JIU9@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_4834482_2	649638.Trad_0629	5.708e-172	551.0	COG2124@1|root,COG2124@2|Bacteria	2|Bacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_4834482_3	1267535.KB906767_gene4432	1.094e-170	574.0	COG1629@1|root,COG1629@2|Bacteria,3Y620@57723|Acidobacteria,2JKZX@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_4834482_1	1340493.JNIF01000003_gene1499	2.778e-178	584.0	COG0457@1|root,COG0457@2|Bacteria,3Y7CG@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
TLS2_k127_4834482_5	1340493.JNIF01000003_gene1498	5.661e-69	242.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_4834482_6	1267535.KB906767_gene3467	1.799e-46	173.0	COG1366@1|root,COG1366@2|Bacteria,3Y83J@57723|Acidobacteria	57723|Acidobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS2_k127_4834482_7	234267.Acid_3880	7.02e-26	109.0	COG1225@1|root,COG1225@2|Bacteria,3Y8N3@57723|Acidobacteria	57723|Acidobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_4843678_1	1267535.KB906767_gene2015	2.152e-43	159.0	COG2801@1|root,COG2801@2|Bacteria,3Y821@57723|Acidobacteria	57723|Acidobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
TLS2_k127_4843678_0	1267535.KB906767_gene2038	9.15e-180	568.0	COG2801@1|root,COG2801@2|Bacteria,3Y821@57723|Acidobacteria	57723|Acidobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
TLS2_k127_4849968_0	1267535.KB906767_gene5366	3.399e-191	608.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Dioxygenase_C,TonB_dep_Rec
TLS2_k127_4849968_1	1267535.KB906767_gene2306	2.407e-83	291.0	COG1629@1|root,COG1629@2|Bacteria,3Y9AK@57723|Acidobacteria	57723|Acidobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_4851853_1	1449076.JOOE01000005_gene1625	8.604e-107	353.0	COG0644@1|root,COG0644@2|Bacteria,1R41S@1224|Proteobacteria,2TW03@28211|Alphaproteobacteria,2KESW@204457|Sphingomonadales	204457|Sphingomonadales	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
TLS2_k127_4851853_0	1449076.JOOE01000005_gene1624	5.586e-127	429.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1P4TP@1224|Proteobacteria,2UNU1@28211|Alphaproteobacteria,2K2AF@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
TLS2_k127_4852292_1	234267.Acid_0844	7.375e-104	355.0	COG0673@1|root,COG0673@2|Bacteria,3Y6RA@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,TAT_signal
TLS2_k127_4852292_0	234267.Acid_2974	2.137e-271	871.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_4854896_1	1144275.COCOR_02595	4.264e-20	93.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions,2WN7A@28221|Deltaproteobacteria,2YTZA@29|Myxococcales	28221|Deltaproteobacteria	Q	non-ribosomal peptide synthetase	-	-	-	ko:K16416	ko01052,map01052	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
TLS2_k127_4854896_0	1274524.BSONL12_21789	9.578e-238	770.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HV19@91061|Bacilli,1ZD1S@1386|Bacillus	91061|Bacilli	Q	Polyketide synthase of type I	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NAD_binding_4,PP-binding,PS-DH,ketoacyl-synt
TLS2_k127_48562_1	1007105.PT7_3292	1.88e-57	205.0	COG2128@1|root,COG2128@2|Bacteria,1MVWP@1224|Proteobacteria,2VS89@28216|Betaproteobacteria,3T3PQ@506|Alcaligenaceae	28216|Betaproteobacteria	S	Alkylhydroperoxidase AhpD family core domain-containing protein 7	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_48562_0	1207063.P24_05562	9.291e-158	505.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2TQKN@28211|Alphaproteobacteria,2JPPQ@204441|Rhodospirillales	204441|Rhodospirillales	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
TLS2_k127_48562_2	1038860.AXAP01000088_gene3672	1.089e-40	154.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,3JVJ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
TLS2_k127_4857156_2	234267.Acid_7759	2.522e-93	312.0	COG1185@1|root,COG1185@2|Bacteria,3Y2UG@57723|Acidobacteria	57723|Acidobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TLS2_k127_4857156_1	234267.Acid_5338	1.518e-124	423.0	COG0666@1|root,COG1657@1|root,COG0666@2|Bacteria,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amino_oxidase,Ank_2,Ank_4,Ank_5,PSCyt1,Prenyltrans,SQHop_cyclase_C
TLS2_k127_4857156_0	439235.Dalk_3033	5.221e-141	458.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2MISS@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TLS2_k127_4868294_0	1123248.KB893326_gene1391	1.354e-225	702.0	COG0422@1|root,COG0422@2|Bacteria,4NFTF@976|Bacteroidetes,1INSZ@117747|Sphingobacteriia	976|Bacteroidetes	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
TLS2_k127_4868294_3	946483.Cenrod_0606	6.594e-25	110.0	COG3620@1|root,COG3620@2|Bacteria,1QVZN@1224|Proteobacteria,2VWDC@28216|Betaproteobacteria,4AG3T@80864|Comamonadaceae	28216|Betaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS2_k127_4868294_2	243231.GSU1391	1.605e-50	188.0	COG2184@1|root,COG2184@2|Bacteria,1RAVF@1224|Proteobacteria,42TM9@68525|delta/epsilon subdivisions,2WUZ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
TLS2_k127_4868294_1	861299.J421_5766	1.956e-89	300.0	COG1506@1|root,COG1506@2|Bacteria,1ZUYN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
TLS2_k127_4868912_14	1306174.JODP01000013_gene7620	3.76e-60	215.0	COG5002@1|root,COG5002@2|Bacteria,2I2TP@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,dCache_1
TLS2_k127_4868912_18	234267.Acid_0132	1.432e-33	133.0	COG1923@1|root,COG1923@2|Bacteria,3Y5JI@57723|Acidobacteria	57723|Acidobacteria	S	Hfq protein	-	-	-	-	-	-	-	-	-	-	-	-	Hfq
TLS2_k127_4868912_7	1340493.JNIF01000003_gene2807	8.374e-121	396.0	COG0470@1|root,COG0470@2|Bacteria	2|Bacteria	L	replication factor c	holB	-	2.7.7.7	ko:K02341,ko:K02343,ko:K09384	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
TLS2_k127_4868912_15	234267.Acid_7330	1.809e-59	213.0	COG0125@1|root,COG0125@2|Bacteria,3Y562@57723|Acidobacteria	57723|Acidobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
TLS2_k127_4868912_9	234267.Acid_2350	1.762e-107	354.0	COG1573@1|root,COG1573@2|Bacteria,3Y43G@57723|Acidobacteria	57723|Acidobacteria	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_4868912_4	1267535.KB906767_gene1438	1.013e-160	519.0	COG0452@1|root,COG0452@2|Bacteria,3Y2QJ@57723|Acidobacteria,2JIK5@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TLS2_k127_4868912_21	1267535.KB906767_gene1437	3.168e-21	96.0	COG1758@1|root,COG1758@2|Bacteria	2|Bacteria	K	DNA-directed 5'-3' RNA polymerase activity	rpoZ	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
TLS2_k127_4868912_13	1267535.KB906767_gene1436	3.15e-73	264.0	COG0194@1|root,COG0194@2|Bacteria,3Y2JW@57723|Acidobacteria,2JJ0I@204432|Acidobacteriia	204432|Acidobacteriia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
TLS2_k127_4868912_12	234267.Acid_2354	2.244e-81	285.0	COG1561@1|root,COG1561@2|Bacteria,3Y2HQ@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
TLS2_k127_4868912_0	1340493.JNIF01000003_gene2817	4.693e-231	733.0	COG1132@1|root,COG1132@2|Bacteria,3Y2Y9@57723|Acidobacteria	57723|Acidobacteria	V	PFAM ABC transporter	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
TLS2_k127_4868912_10	1340493.JNIF01000003_gene2818	3.146e-103	344.0	COG0859@1|root,COG0859@2|Bacteria,3Y616@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TLS2_k127_4868912_20	1267535.KB906767_gene1432	3.074e-22	96.0	COG2835@1|root,COG2835@2|Bacteria,3Y8VE@57723|Acidobacteria	57723|Acidobacteria	S	Trm112p-like protein	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
TLS2_k127_4868912_11	234267.Acid_3906	6.161e-94	323.0	COG0673@1|root,COG0673@2|Bacteria,3Y66I@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_4868912_3	1340493.JNIF01000004_gene304	7.901e-177	584.0	COG1404@1|root,COG5164@1|root,COG1404@2|Bacteria,COG5164@2|Bacteria,3Y5WB@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8
TLS2_k127_4868912_8	1267534.KB906754_gene3093	6.021e-114	382.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	MA20_35850	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_4868912_6	926549.KI421517_gene1084	4.796e-140	455.0	28JXC@1|root,2Z8EX@2|Bacteria,4NF7D@976|Bacteroidetes,47M9Z@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4868912_5	1340493.JNIF01000003_gene1945	2.825e-150	488.0	COG1109@1|root,COG1109@2|Bacteria	2|Bacteria	G	phosphoglucosamine mutase activity	-	-	5.4.2.10,5.4.2.2,5.4.2.8	ko:K03431,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R02060,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_4868912_2	1340493.JNIF01000003_gene1944	1.953e-182	582.0	COG1109@1|root,COG1109@2|Bacteria	2|Bacteria	G	phosphoglucosamine mutase activity	glmM	-	5.4.2.10,5.4.2.2,5.4.2.8	ko:K01840,ko:K03431,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R02060,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_4868912_19	234267.Acid_6359	2.12e-32	131.0	COG1324@1|root,COG1324@2|Bacteria,3Y5P7@57723|Acidobacteria	57723|Acidobacteria	P	CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
TLS2_k127_4868912_1	861299.J421_0476	5.81e-191	626.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZTK4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
TLS2_k127_4868912_16	861299.J421_0475	5.241e-48	179.0	COG1595@1|root,COG1595@2|Bacteria,1ZUZ9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_4868912_17	639030.JHVA01000001_gene387	2.002e-44	184.0	2E0ZT@1|root,32WFZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4869059_3	234267.Acid_5981	1.336e-76	260.0	COG0577@1|root,COG0577@2|Bacteria,3Y3XI@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_4869059_0	1267535.KB906767_gene5492	1.547e-115	384.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS2_k127_4869059_4	215803.DB30_1762	3.084e-41	156.0	COG1359@1|root,COG1359@2|Bacteria,1RI7W@1224|Proteobacteria,42Y4G@68525|delta/epsilon subdivisions,2WTC4@28221|Deltaproteobacteria,2YV68@29|Myxococcales	28221|Deltaproteobacteria	C	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS2_k127_4869059_1	234267.Acid_3896	2.62e-108	378.0	COG1454@1|root,COG1454@2|Bacteria,3Y575@57723|Acidobacteria	57723|Acidobacteria	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
TLS2_k127_4869059_2	234267.Acid_5981	5.798e-104	351.0	COG0577@1|root,COG0577@2|Bacteria,3Y3XI@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_4870510_1	78245.Xaut_3310	3.663e-16	81.0	COG0463@1|root,COG2246@1|root,COG0463@2|Bacteria,COG2246@2|Bacteria,1MV8J@1224|Proteobacteria,2TTYF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferase, family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
TLS2_k127_4870510_0	448385.sce8790	7.084e-83	286.0	COG0492@1|root,COG0492@2|Bacteria,1MVWS@1224|Proteobacteria,42YY5@68525|delta/epsilon subdivisions,2WPYC@28221|Deltaproteobacteria,2YUGH@29|Myxococcales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
TLS2_k127_4870510_2	641491.DND132_2717	0.0005102	43.0	COG0589@1|root,COG1914@1|root,COG0589@2|Bacteria,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,42PNI@68525|delta/epsilon subdivisions,2WJNF@28221|Deltaproteobacteria,2M9NW@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM natural resistance-associated macrophage protein	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp,Usp
TLS2_k127_4871291_1	379066.GAU_3906	2.602e-26	111.0	COG3055@1|root,COG3055@2|Bacteria,1ZUV8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4
TLS2_k127_4871291_0	1449076.JOOE01000004_gene137	1.575e-88	307.0	COG1680@1|root,COG1680@2|Bacteria,1R8N7@1224|Proteobacteria,2UCNR@28211|Alphaproteobacteria,2K0VY@204457|Sphingomonadales	204457|Sphingomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_4884236_2	1340493.JNIF01000003_gene2023	1.04e-80	275.0	COG1450@1|root,COG1450@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	gspD	-	-	ko:K02453,ko:K03219	ko03070,ko05111,map03070,map05111	M00331,M00332,M00542	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15,3.A.6.1,3.A.6.3	-	-	Secretin,Secretin_N
TLS2_k127_4884236_0	1267533.KB906733_gene3362	1.925e-101	355.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS2_k127_4884236_3	1297569.MESS2_1280010	3.738e-63	226.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,2TUVZ@28211|Alphaproteobacteria,43JW9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	Isochorismatase family	rutB	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
TLS2_k127_4884236_1	926569.ANT_29640	1.307e-81	278.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS2_k127_488883_0	675635.Psed_3703	4.427e-54	198.0	COG0596@1|root,COG0596@2|Bacteria,2HEMJ@201174|Actinobacteria,4DYUK@85010|Pseudonocardiales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_4889540_1	240015.ACP_2222	6.915e-08	55.0	COG0617@1|root,COG0617@2|Bacteria,3Y3B8@57723|Acidobacteria,2JIIS@204432|Acidobacteriia	204432|Acidobacteriia	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
TLS2_k127_4889540_0	234267.Acid_5958	9.148e-183	582.0	COG4952@1|root,COG4952@2|Bacteria,3Y3J5@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Xylose isomerase	-	-	5.3.1.14	ko:K01820	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01906,R02437,R06589	RC00376,RC00434,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_4891093_0	102232.GLO73106DRAFT_00012360	2.41e-23	100.0	COG3335@1|root,COG3335@2|Bacteria,1G53U@1117|Cyanobacteria	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_33
TLS2_k127_4891093_2	460265.Mnod_6406	2.848e-05	47.0	COG3464@1|root,COG3464@2|Bacteria,1QW5Z@1224|Proteobacteria,2U3N2@28211|Alphaproteobacteria,1JZK2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	zinc-finger binding domain of transposase IS66	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
TLS2_k127_4910021_1	1299327.I546_5558	1.552e-78	269.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,23B0M@1762|Mycobacteriaceae	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
TLS2_k127_4910021_3	298653.Franean1_2887	7.04e-43	160.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4ERUS@85013|Frankiales	201174|Actinobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
TLS2_k127_4910021_2	234267.Acid_4470	5.314e-54	199.0	COG0727@1|root,COG0727@2|Bacteria,3Y4VW@57723|Acidobacteria	57723|Acidobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
TLS2_k127_4910021_0	1340493.JNIF01000003_gene4606	1.201e-88	296.0	COG4445@1|root,COG4445@2|Bacteria,3Y8RX@57723|Acidobacteria	57723|Acidobacteria	FJ	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)	-	-	-	ko:K06169	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MiaE
TLS2_k127_4918020_1	234267.Acid_4577	9.105e-79	271.0	COG4993@1|root,COG4993@2|Bacteria,3Y696@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
TLS2_k127_4918020_0	234267.Acid_3494	2.736e-94	320.0	COG0457@1|root,COG0457@2|Bacteria,3Y6B2@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
TLS2_k127_4918020_2	234267.Acid_3491	1.907e-28	125.0	COG0457@1|root,COG0457@2|Bacteria,3Y8AI@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
TLS2_k127_4919629_0	667632.KB890168_gene5189	4.353e-206	650.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VHC1@28216|Betaproteobacteria,1K09M@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	1.16.1.1	ko:K00520,ko:K21739	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_4919629_6	396588.Tgr7_3168	1.487e-27	113.0	COG0322@1|root,COG0322@2|Bacteria,1R5TC@1224|Proteobacteria,1S0PX@1236|Gammaproteobacteria,1X0C8@135613|Chromatiales	135613|Chromatiales	L	Domain of unknown function (DUF4357)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4357
TLS2_k127_4919629_3	631362.Thi970DRAFT_03846	6.998e-66	228.0	COG0322@1|root,COG0322@2|Bacteria,1R5TC@1224|Proteobacteria,1S0PX@1236|Gammaproteobacteria,1X0C8@135613|Chromatiales	135613|Chromatiales	L	Domain of unknown function (DUF4357)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4357
TLS2_k127_4919629_2	935567.JAES01000020_gene574	4.858e-69	236.0	COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,1S69N@1236|Gammaproteobacteria,1X6M5@135614|Xanthomonadales	135614|Xanthomonadales	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_4919629_5	263358.VAB18032_06840	2.369e-31	130.0	COG3795@1|root,COG3795@2|Bacteria,2HQVV@201174|Actinobacteria,4DE2W@85008|Micromonosporales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_4919629_1	1246995.AFR_01035	1.808e-188	597.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4D9DP@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4919629_4	589865.DaAHT2_2624	1.081e-46	173.0	COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,43B7V@68525|delta/epsilon subdivisions,2X6MA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Lipocalin / cytosolic fatty-acid binding protein family	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
TLS2_k127_4919653_0	1232410.KI421425_gene1521	1.25e-188	602.0	COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria,43SDT@69541|Desulfuromonadales	28221|Deltaproteobacteria	A	Domain of unknown function (DUF3552)	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
TLS2_k127_4919653_2	404589.Anae109_1095	1.597e-90	304.0	COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,42PCG@68525|delta/epsilon subdivisions,2WM8X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Metallophosphoesterase	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
TLS2_k127_4919653_1	314278.NB231_08758	2.915e-137	448.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1WX6G@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TLS2_k127_4919653_5	1123371.ATXH01000052_gene627	2.043e-18	87.0	2DTS4@1|root,33MFD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4919653_3	221288.JH992901_gene4347	2.469e-32	129.0	2DPM9@1|root,332MQ@2|Bacteria,1GAJY@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4919653_4	411470.RUMGNA_02974	6.752e-22	95.0	2DN97@1|root,32W7A@2|Bacteria,1VANB@1239|Firmicutes,24Q9J@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4927829_2	1411123.JQNH01000001_gene1231	1.6e-09	64.0	2994E@1|root,2ZW7W@2|Bacteria,1P7Q4@1224|Proteobacteria,2UWIZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4927829_1	1163407.UU7_04927	6.114e-36	141.0	COG2885@1|root,COG2885@2|Bacteria,1RB3C@1224|Proteobacteria,1S36Z@1236|Gammaproteobacteria,1X77V@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS2_k127_4927829_3	903818.KI912268_gene2380	6.807e-07	54.0	COG2885@1|root,COG2885@2|Bacteria,3Y5IQ@57723|Acidobacteria	57723|Acidobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	DUF937,OmpA
TLS2_k127_4927829_0	234267.Acid_1026	7.68e-49	180.0	COG2027@1|root,COG2027@2|Bacteria,3Y3WF@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
TLS2_k127_4929963_1	234267.Acid_6397	6.233e-155	499.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria	2|Bacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890,ko:K06878	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,RNA_ligase,tRNA_bind
TLS2_k127_4929963_0	1340493.JNIF01000003_gene1736	2.294e-171	543.0	COG0016@1|root,COG0016@2|Bacteria,3Y3NJ@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
TLS2_k127_4931673_0	1340493.JNIF01000004_gene560	4.225e-200	642.0	COG2120@1|root,COG2120@2|Bacteria,3Y3BV@57723|Acidobacteria	57723|Acidobacteria	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_4931673_1	234267.Acid_1107	8.948e-195	621.0	COG0591@1|root,COG0591@2|Bacteria,3Y6FC@57723|Acidobacteria	57723|Acidobacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_4931673_2	1267535.KB906767_gene3226	1.789e-87	293.0	COG1595@1|root,COG1595@2|Bacteria,3Y3BS@57723|Acidobacteria,2JIDF@204432|Acidobacteriia	204432|Acidobacteriia	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4931673_3	234267.Acid_3316	1.413e-08	64.0	2E1AY@1|root,32WQW@2|Bacteria,3Y8WG@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4957914_0	234267.Acid_3330	8.958e-62	228.0	COG2948@1|root,COG2948@2|Bacteria	2|Bacteria	U	multi-organism process	-	-	-	ko:K03195	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbI
TLS2_k127_4957914_3	1340493.JNIF01000003_gene4812	4.907e-24	113.0	COG2017@1|root,COG2017@2|Bacteria	2|Bacteria	G	converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
TLS2_k127_4957914_4	477184.KYC_21766	8.643e-14	79.0	COG3945@1|root,COG3945@2|Bacteria,1N0BD@1224|Proteobacteria,2VUY4@28216|Betaproteobacteria,3T3VG@506|Alcaligenaceae	28216|Betaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS2_k127_4957914_1	234267.Acid_2922	9.956e-59	212.0	COG2846@1|root,COG2846@2|Bacteria,3Y4SU@57723|Acidobacteria	57723|Acidobacteria	C	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
TLS2_k127_4957914_2	234267.Acid_2922	3.439e-43	166.0	COG2846@1|root,COG2846@2|Bacteria,3Y4SU@57723|Acidobacteria	57723|Acidobacteria	C	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
TLS2_k127_4959678_1	234267.Acid_1528	5.837e-77	263.0	COG3119@1|root,COG3119@2|Bacteria,3Y3PF@57723|Acidobacteria	2|Bacteria	P	PFAM Sulfatase	atsA	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
TLS2_k127_4959678_3	234267.Acid_0138	1.839e-06	61.0	COG3806@1|root,COG3806@2|Bacteria,3Y5HQ@57723|Acidobacteria	57723|Acidobacteria	T	Anti-sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4959678_2	1267533.KB906733_gene3179	9.893e-38	147.0	COG1595@1|root,COG1595@2|Bacteria,3Y8VG@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4959678_0	1340493.JNIF01000003_gene3464	2.141e-143	486.0	COG1629@1|root,COG4771@2|Bacteria,3Y77Q@57723|Acidobacteria	57723|Acidobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_4965689_2	1379270.AUXF01000001_gene2394	3.918e-46	179.0	COG0719@1|root,COG0719@2|Bacteria,1ZSTG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
TLS2_k127_4965689_1	861299.J421_2089	2.615e-129	416.0	COG0396@1|root,COG0396@2|Bacteria,1ZSRX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ABC transporter	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
TLS2_k127_4965689_0	861299.J421_2090	2.6e-170	536.0	COG0719@1|root,COG0719@2|Bacteria,1ZSMU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TLS2_k127_4970434_0	1340493.JNIF01000003_gene3949	5.236e-163	517.0	COG0463@1|root,COG0463@2|Bacteria,3Y30V@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_4970434_1	56107.Cylst_1736	1.121e-131	444.0	COG0076@1|root,COG0076@2|Bacteria,1G3F8@1117|Cyanobacteria,1HP30@1161|Nostocales	1117|Cyanobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.15,4.1.1.28,4.1.1.86	ko:K01580,ko:K01593,ko:K13745	ko00250,ko00260,ko00350,ko00360,ko00380,ko00410,ko00430,ko00650,ko00901,ko00950,ko00965,ko01100,ko01110,ko01120,ko02024,ko04726,ko04727,ko04728,ko04940,ko05030,ko05031,ko05034,map00250,map00260,map00350,map00360,map00380,map00410,map00430,map00650,map00901,map00950,map00965,map01100,map01110,map01120,map02024,map04726,map04727,map04728,map04940,map05030,map05031,map05034	M00027,M00037,M00042	R00261,R00489,R00685,R00699,R00736,R01682,R02080,R02466,R02701,R04909,R07650	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS2_k127_4970434_2	1340493.JNIF01000003_gene4413	4.698e-14	74.0	COG3267@1|root,COG3267@2|Bacteria,3Y6P4@57723|Acidobacteria	57723|Acidobacteria	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
TLS2_k127_4980364_0	1121920.AUAU01000018_gene1783	2.201e-264	827.0	COG1506@1|root,COG1506@2|Bacteria,3Y3XQ@57723|Acidobacteria	57723|Acidobacteria	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_4980364_2	1121904.ARBP01000055_gene491	6.443e-78	286.0	COG2984@1|root,COG2984@2|Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind
TLS2_k127_4980364_1	926549.KI421517_gene2437	4.848e-123	419.0	COG2610@1|root,COG2610@2|Bacteria,4NFBD@976|Bacteroidetes,47KJN@768503|Cytophagia	976|Bacteroidetes	EG	TIGRFAM gluconate transporter	-	-	-	ko:K06155,ko:K06157	-	-	-	-	ko00000,ko02000	2.A.8.1.2,2.A.8.1.4	-	-	GntP_permease
TLS2_k127_4980407_1	234267.Acid_6718	9.561e-133	429.0	COG1577@1|root,COG1577@2|Bacteria	2|Bacteria	I	mevalonate kinase activity	mvaK2	-	2.7.1.36,2.7.1.43,2.7.4.2	ko:K00869,ko:K00938,ko:K16190	ko00040,ko00053,ko00520,ko00900,ko01100,ko01110,ko01130,ko04146,map00040,map00053,map00520,map00900,map01100,map01110,map01130,map04146	M00014,M00095	R01476,R02245,R03245	RC00002,RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_4980407_0	234267.Acid_6722	9.686e-151	483.0	COG0150@1|root,COG0150@2|Bacteria,3Y2GN@57723|Acidobacteria	57723|Acidobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_4980407_2	234267.Acid_6723	2.855e-90	301.0	COG0299@1|root,COG0299@2|Bacteria,3Y49G@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
TLS2_k127_4987208_0	1340493.JNIF01000003_gene2320	2.666e-215	689.0	COG1629@1|root,COG4771@2|Bacteria	1340493.JNIF01000003_gene2320|-	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4987208_1	1382306.JNIM01000001_gene2802	2.657e-118	389.0	COG1879@1|root,COG1879@2|Bacteria,2G6R2@200795|Chloroflexi	200795|Chloroflexi	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K10439,ko:K17213	ko02010,ko02030,map02010,map02030	M00212,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TLS2_k127_4987208_2	1122963.AUHB01000002_gene797	1.136e-110	368.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2TUYW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K17203	ko02010,map02010	M00590	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.11,3.A.1.2.16	-	-	BPD_transp_2
TLS2_k127_4989973_6	485913.Krac_10712	0.0001259	48.0	2CFP1@1|root,32UTJ@2|Bacteria	2|Bacteria	S	Calcium binding	-	-	-	-	-	-	-	-	-	-	-	-	Calci_bind_CcbP
TLS2_k127_4989973_3	234267.Acid_6125	2.239e-94	314.0	COG1961@1|root,COG1961@2|Bacteria,3Y5HT@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_7,Resolvase
TLS2_k127_4989973_4	234267.Acid_2946	5.328e-33	129.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,PRiA4_ORF3
TLS2_k127_4989973_0	1267535.KB906767_gene1217	7.64e-154	491.0	COG4974@1|root,COG4974@2|Bacteria,3Y6KW@57723|Acidobacteria	57723|Acidobacteria	L	phage integrase domain protein SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_4989973_1	1267535.KB906767_gene1216	3.479e-150	485.0	COG0582@1|root,COG0582@2|Bacteria,3Y5HJ@57723|Acidobacteria	57723|Acidobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_4989973_2	1267535.KB906767_gene1215	1.652e-140	458.0	COG4974@1|root,COG4974@2|Bacteria,3Y7QG@57723|Acidobacteria	57723|Acidobacteria	L	phage integrase domain protein SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_4989973_5	344747.PM8797T_15246	7.607e-13	68.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,PRiA4_ORF3,zf-IS66
TLS2_k127_4994178_5	234267.Acid_4069	1.404e-119	387.0	COG0065@1|root,COG0065@2|Bacteria,3Y2ID@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TLS2_k127_4994178_2	234267.Acid_4068	8.878e-188	594.0	COG0473@1|root,COG0473@2|Bacteria,3Y38Z@57723|Acidobacteria	57723|Acidobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_4994178_1	234267.Acid_4067	6.494e-192	604.0	COG0119@1|root,COG0119@2|Bacteria,3Y2WT@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS2_k127_4994178_4	1267535.KB906767_gene3362	1.326e-138	445.0	COG0583@1|root,COG0583@2|Bacteria,3Y31P@57723|Acidobacteria,2JIC0@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_4994178_0	1279009.ADICEAN_03089	6.328e-199	631.0	COG0612@1|root,COG0612@2|Bacteria,4NE0K@976|Bacteroidetes,47TKT@768503|Cytophagia	976|Bacteroidetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_4994178_3	234267.Acid_0503	1.388e-152	496.0	COG0612@1|root,COG0612@2|Bacteria,3Y7EH@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16_C
TLS2_k127_4994178_7	234267.Acid_7226	4.307e-104	346.0	COG3291@1|root,COG3291@2|Bacteria,3Y76G@57723|Acidobacteria	57723|Acidobacteria	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_4994178_6	234267.Acid_5045	1.627e-104	346.0	COG1082@1|root,COG1082@2|Bacteria,3Y61S@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_4994178_8	1198114.AciX9_2897	7.544e-103	353.0	COG1404@1|root,COG5164@1|root,COG1404@2|Bacteria,COG5164@2|Bacteria,3Y5WB@57723|Acidobacteria,2JK6I@204432|Acidobacteriia	204432|Acidobacteriia	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS2_k127_4998510_1	661478.OP10G_3837	3.937e-83	286.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_4998510_0	1340493.JNIF01000003_gene1982	3.045e-160	523.0	COG3127@1|root,COG3127@2|Bacteria,3Y2PA@57723|Acidobacteria	57723|Acidobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_5001088_1	1340493.JNIF01000003_gene3099	4.091e-17	89.0	COG4639@1|root,COG4639@2|Bacteria,3Y3YS@57723|Acidobacteria	57723|Acidobacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
TLS2_k127_5001088_0	1267535.KB906767_gene1738	2.331e-178	577.0	COG3829@1|root,COG3829@2|Bacteria,3Y6K2@57723|Acidobacteria	57723|Acidobacteria	KT	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat,Yop-YscD_cpl
TLS2_k127_500645_0	313628.LNTAR_01922	4.408e-89	301.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_500645_1	1340493.JNIF01000004_gene245	3.087e-62	220.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Calx-beta,CarboxypepD_reg,DUF1080,F5_F8_type_C,G5,G8,Glyco_hyd_101C,Glyco_hydro_101,Trypsin_2,YSIRK_signal,fn3
TLS2_k127_500645_4	290317.Cpha266_1048	1.202e-13	77.0	COG1357@1|root,COG1357@2|Bacteria,1FEX7@1090|Chlorobi	1090|Chlorobi	S	PFAM pentapeptide repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
TLS2_k127_500645_2	861299.J421_0153	5.505e-40	165.0	COG4409@1|root,COG4409@2|Bacteria,1ZUI0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_500645_3	1267535.KB906767_gene1521	2.603e-24	109.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Dioxygenase_C,TonB_dep_Rec
TLS2_k127_5014728_1	927658.AJUM01000044_gene614	3.052e-71	250.0	COG1082@1|root,COG1082@2|Bacteria,4NFMD@976|Bacteroidetes	976|Bacteroidetes	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_5014728_0	1267535.KB906767_gene4920	6.223e-120	404.0	COG1629@1|root,COG4771@2|Bacteria,3Y7CC@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_5018879_3	1267535.KB906767_gene1079	1.821e-125	404.0	COG0499@1|root,COG0499@2|Bacteria,3Y2J2@57723|Acidobacteria,2JIFV@204432|Acidobacteriia	204432|Acidobacteriia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS2_k127_5018879_2	1267535.KB906767_gene1080	1.794e-132	428.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,3Y7FH@57723|Acidobacteria	57723|Acidobacteria	K	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,Methyltransf_11
TLS2_k127_5018879_0	234267.Acid_2499	1.945e-243	760.0	COG2308@1|root,COG2308@2|Bacteria,3Y2FR@57723|Acidobacteria	57723|Acidobacteria	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
TLS2_k127_5018879_1	234267.Acid_2498	3.452e-134	437.0	COG2307@1|root,COG2307@2|Bacteria,3Y3AM@57723|Acidobacteria	57723|Acidobacteria	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
TLS2_k127_5018879_4	234267.Acid_2497	5.712e-118	383.0	COG3484@1|root,COG3484@2|Bacteria,3Y5QF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_5018879_5	234267.Acid_2496	1.533e-79	276.0	COG1305@1|root,COG1305@2|Bacteria,3Y8Q6@57723|Acidobacteria	57723|Acidobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
TLS2_k127_5018879_7	1312954.KI914877_gene1070	1.327e-18	99.0	COG0702@1|root,COG0702@2|Bacteria,2ICEY@201174|Actinobacteria,1WBP0@1268|Micrococcaceae	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
TLS2_k127_5018879_6	1121920.AUAU01000006_gene330	2.632e-75	278.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y6VR@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_5019738_1	313596.RB2501_10772	1.767e-123	403.0	COG3119@1|root,COG3119@2|Bacteria,4NEPB@976|Bacteroidetes,1HYHN@117743|Flavobacteriia	976|Bacteroidetes	P	Pfam Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_5019738_0	639030.JHVA01000001_gene2315	5.606e-186	592.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
TLS2_k127_5019738_2	1340493.JNIF01000004_gene597	6.921e-76	266.0	COG1629@1|root,COG1629@2|Bacteria,3Y6Z5@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_5021011_3	1267535.KB906767_gene2486	3.512e-39	152.0	2DWVU@1|root,3424P@2|Bacteria,3Y8CU@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5021011_5	518766.Rmar_1878	3.033e-30	131.0	COG1432@1|root,COG1432@2|Bacteria,4PESH@976|Bacteroidetes,1FJIZ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
TLS2_k127_5021011_2	1267535.KB906767_gene825	1.155e-130	424.0	COG1940@1|root,COG1940@2|Bacteria,3Y4DD@57723|Acidobacteria,2JJ4T@204432|Acidobacteriia	204432|Acidobacteriia	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_5021011_0	1267535.KB906767_gene824	2.809e-225	706.0	COG1070@1|root,COG1070@2|Bacteria,3Y2V6@57723|Acidobacteria,2JJ35@204432|Acidobacteriia	204432|Acidobacteriia	G	FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS2_k127_5021011_1	204669.Acid345_3774	1.245e-220	709.0	COG1198@1|root,COG1198@2|Bacteria,3Y2NY@57723|Acidobacteria,2JI1K@204432|Acidobacteriia	204432|Acidobacteriia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
TLS2_k127_5021011_4	1242864.D187_010410	5.885e-34	140.0	COG0454@1|root,COG0456@2|Bacteria,1NCW1@1224|Proteobacteria,42XYS@68525|delta/epsilon subdivisions,2WT5Q@28221|Deltaproteobacteria,2Z06J@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_9
TLS2_k127_5022049_3	1267535.KB906767_gene2498	1.147e-114	381.0	COG3520@1|root,COG3520@2|Bacteria,3Y49W@57723|Acidobacteria,2JMM9@204432|Acidobacteriia	204432|Acidobacteriia	S	type VI secretion protein, VC_A0111 family	-	-	-	ko:K11895	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssG
TLS2_k127_5022049_0	234267.Acid_0237	3.079e-264	826.0	COG3519@1|root,COG3519@2|Bacteria,3Y34T@57723|Acidobacteria	57723|Acidobacteria	S	Type VI secretion system, TssF	-	-	-	ko:K11896	-	M00334	-	-	ko00000,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssF
TLS2_k127_5022049_6	234267.Acid_0236	2.335e-52	189.0	COG3518@1|root,COG3518@2|Bacteria,3Y5IK@57723|Acidobacteria	57723|Acidobacteria	S	Gene 25-like lysozyme	-	-	-	ko:K11897	-	M00334	-	-	ko00000,ko00002,ko02044	-	-	-	GPW_gp25
TLS2_k127_5022049_2	234267.Acid_0235	5.294e-150	495.0	COG3515@1|root,COG3515@2|Bacteria,3Y2NF@57723|Acidobacteria	57723|Acidobacteria	S	ImpA, N-terminal, type VI secretion system	-	-	-	ko:K11902	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	ImpA_N,T6SS_VasJ
TLS2_k127_5022049_4	234267.Acid_0234	3.944e-93	311.0	COG4455@1|root,COG4455@2|Bacteria,3Y73H@57723|Acidobacteria	57723|Acidobacteria	S	ImpE protein	-	-	-	ko:K11898	-	-	-	-	ko00000,ko02044	-	-	-	ImpE
TLS2_k127_5022049_7	231434.JQJH01000013_gene2937	3.513e-43	163.0	COG3157@1|root,COG3157@2|Bacteria,1RBTU@1224|Proteobacteria,2U1NF@28211|Alphaproteobacteria,3NBIR@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Type VI secretion system effector, Hcp	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
TLS2_k127_5022049_1	234267.Acid_0232	6.117e-258	802.0	COG3517@1|root,COG3517@2|Bacteria,3Y2RM@57723|Acidobacteria	57723|Acidobacteria	S	Type VI secretion protein, EvpB/VC_A0108, tail sheath	-	-	-	ko:K11900	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	VipB
TLS2_k127_5022049_5	1340493.JNIF01000004_gene594	4.239e-73	250.0	COG3516@1|root,COG3516@2|Bacteria,3Y4M4@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Uncharacterised conserved protein UCP028301	-	-	-	ko:K11901	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_VipA
TLS2_k127_5022049_8	234267.Acid_0227	2.059e-39	149.0	COG3522@1|root,COG3522@2|Bacteria,3Y3ZF@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE	-	-	-	ko:K11893	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_VasE
TLS2_k127_5026911_2	1123242.JH636435_gene2126	0.0005679	45.0	COG0673@1|root,COG0673@2|Bacteria,2IXVF@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_5026911_0	886293.Sinac_3587	9.127e-56	203.0	COG0673@1|root,COG0673@2|Bacteria,2IXVF@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_5026911_1	234267.Acid_4014	1.096e-42	169.0	COG0673@1|root,COG0673@2|Bacteria,3Y4KS@57723|Acidobacteria	2|Bacteria	S	PFAM oxidoreductase domain protein	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_5031_2	234267.Acid_0024	4.089e-89	302.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_5031_3	234267.Acid_3228	2.357e-44	166.0	2D4D1@1|root,32TGT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5031_0	234267.Acid_3308	2.891e-157	505.0	COG0517@1|root,COG0517@2|Bacteria,3Y6WE@57723|Acidobacteria	57723|Acidobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
TLS2_k127_5031_1	234267.Acid_4752	4.571e-96	323.0	COG4974@1|root,COG4974@2|Bacteria,3Y68K@57723|Acidobacteria	57723|Acidobacteria	L	phage integrase domain protein SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
TLS2_k127_5031_4	234267.Acid_6739	4.222e-22	96.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	3.4.13.22	ko:K08641,ko:K11206	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	CN_hydrolase,Peptidase_M15
TLS2_k127_5035840_4	232721.Ajs_1754	0.0004317	43.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,4ADVR@80864|Comamonadaceae	28216|Betaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
TLS2_k127_5035840_2	1266925.JHVX01000022_gene1765	1.538e-16	80.0	COG3293@1|root,COG3293@2|Bacteria,1N8GF@1224|Proteobacteria,2WBR1@28216|Betaproteobacteria,373MQ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	InterPro IPR002559	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
TLS2_k127_5035840_3	1047013.AQSP01000142_gene124	1.191e-05	57.0	COG3391@1|root,COG3391@2|Bacteria,2NQ4G@2323|unclassified Bacteria	2|Bacteria	O	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,NHL,TolB_like
TLS2_k127_5035840_0	522772.Dacet_0267	3.915e-68	239.0	COG1484@1|root,COG1484@2|Bacteria,2GFU3@200930|Deferribacteres	2|Bacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
TLS2_k127_5035840_1	1247963.JPHU01000019_gene2995	6.638e-21	92.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_29,HTH_32
TLS2_k127_5036727_1	234267.Acid_7718	6.489e-257	814.0	COG1193@1|root,COG1193@2|Bacteria,3Y2Z2@57723|Acidobacteria	57723|Acidobacteria	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
TLS2_k127_5036727_7	234267.Acid_7717	2.078e-48	183.0	COG1051@1|root,COG1051@2|Bacteria,3Y5BM@57723|Acidobacteria	57723|Acidobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_5036727_6	234267.Acid_7716	4.161e-55	203.0	COG3386@1|root,COG3386@2|Bacteria,3Y5XH@57723|Acidobacteria	57723|Acidobacteria	G	SMP-30/Gluconolaconase/LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
TLS2_k127_5036727_5	234267.Acid_1401	2.863e-60	226.0	COG2823@1|root,COG2823@2|Bacteria,3Y4KR@57723|Acidobacteria	57723|Acidobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS2_k127_5036727_0	234267.Acid_7693	1.172e-286	891.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,3Y3NX@57723|Acidobacteria	57723|Acidobacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
TLS2_k127_5036727_3	234267.Acid_7692	5.919e-147	472.0	COG1013@1|root,COG1013@2|Bacteria,3Y3NE@57723|Acidobacteria	57723|Acidobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
TLS2_k127_5036727_2	401053.AciPR4_1573	1.349e-250	825.0	COG1629@1|root,COG4771@2|Bacteria,3Y368@57723|Acidobacteria,2JKVQ@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_5036727_8	509190.Cseg_2419	1.212e-26	118.0	COG4572@1|root,COG4572@2|Bacteria,1NDIJ@1224|Proteobacteria,2TTIY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cation transport regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5036727_4	886293.Sinac_2952	6.472e-68	234.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	soxR	-	-	ko:K13639	-	-	-	-	ko00000,ko03000	-	-	-	MerR,MerR-DNA-bind,MerR_1
TLS2_k127_5040857_0	472759.Nhal_0500	0.0	1223.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TLS2_k127_5047284_0	234267.Acid_4241	4.064e-203	641.0	COG0673@1|root,COG0673@2|Bacteria,3Y6C9@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_5047284_1	314230.DSM3645_24180	4.125e-171	563.0	COG4692@1|root,COG4692@2|Bacteria,2IX4M@203682|Planctomycetes	203682|Planctomycetes	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,VCBS
TLS2_k127_5047284_2	1267535.KB906767_gene677	6.164e-23	101.0	COG1082@1|root,COG1082@2|Bacteria,3Y51R@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_5049391_0	1340493.JNIF01000003_gene4742	9.247e-96	342.0	COG0515@1|root,COG0515@2|Bacteria,3Y3NW@57723|Acidobacteria	57723|Acidobacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_5049391_1	1183438.GKIL_3942	7.385e-46	172.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
TLS2_k127_5052017_0	1163617.SCD_n02090	2.295e-45	173.0	COG3409@1|root,COG3409@2|Bacteria,1R7JY@1224|Proteobacteria,2VY5B@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5056602_0	1340493.JNIF01000003_gene2321	0.0	1410.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,3Y6I3@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_5056602_1	1267535.KB906767_gene2168	6.986e-230	731.0	COG1529@1|root,COG1529@2|Bacteria,3Y3J7@57723|Acidobacteria,2JMHB@204432|Acidobacteriia	204432|Acidobacteriia	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K00256	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_5059749_5	234267.Acid_1656	5.749e-23	102.0	COG0845@1|root,COG0845@2|Bacteria,3Y50Z@57723|Acidobacteria	57723|Acidobacteria	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TLS2_k127_5059749_1	1267535.KB906767_gene3518	5.286e-152	491.0	COG0577@1|root,COG0577@2|Bacteria,3Y4C7@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_5059749_2	1340493.JNIF01000003_gene2504	1.18e-128	424.0	COG0577@1|root,COG0577@2|Bacteria,3Y4MY@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_5059749_4	1340493.JNIF01000003_gene2105	4.495e-51	187.0	COG0590@1|root,COG0590@2|Bacteria,3Y4KB@57723|Acidobacteria	57723|Acidobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	DUF3175,MafB19-deam
TLS2_k127_5059749_3	570952.ATVH01000016_gene2413	8.451e-81	278.0	COG4106@1|root,COG4106@2|Bacteria,1R04W@1224|Proteobacteria,2U5VR@28211|Alphaproteobacteria,2JRTB@204441|Rhodospirillales	204441|Rhodospirillales	S	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_5059749_0	349163.Acry_3583	3.978e-178	567.0	COG0270@1|root,COG0270@2|Bacteria,1PPPH@1224|Proteobacteria,2VAY4@28211|Alphaproteobacteria,2JY24@204441|Rhodospirillales	204441|Rhodospirillales	H	C-5 cytosine-specific DNA methylase	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
TLS2_k127_5063246_0	1238182.C882_2847	0.0	1082.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria,2JQKB@204441|Rhodospirillales	204441|Rhodospirillales	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS2_k127_5063246_1	1121106.JQKB01000064_gene5372	1.413e-30	121.0	COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,2TW4J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	synthase	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
TLS2_k127_5063736_5	1340493.JNIF01000003_gene2821	7.447e-92	305.0	COG0290@1|root,COG0290@2|Bacteria,3Y3VP@57723|Acidobacteria	57723|Acidobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
TLS2_k127_5063736_2	234267.Acid_3589	1.006e-151	487.0	COG1044@1|root,COG1044@2|Bacteria,3Y2JC@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
TLS2_k127_5063736_3	1267535.KB906767_gene5186	1.514e-113	374.0	COG1611@1|root,COG1611@2|Bacteria,3Y2MR@57723|Acidobacteria,2JHUP@204432|Acidobacteriia	204432|Acidobacteriia	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TLS2_k127_5063736_0	1340493.JNIF01000003_gene2275	1.284e-157	519.0	COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,3Y2P9@57723|Acidobacteria	57723|Acidobacteria	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
TLS2_k127_5063736_1	234267.Acid_2158	1.151e-154	503.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,3Y3XN@57723|Acidobacteria	57723|Acidobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
TLS2_k127_5063736_7	234267.Acid_2157	9.647e-45	166.0	COG0802@1|root,COG0802@2|Bacteria,3Y4WF@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Uncharacterised protein family UPF0079, ATPase	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
TLS2_k127_5063736_10	1172562.HCN_1116	0.0003254	48.0	COG2703@1|root,COG2703@2|Bacteria,1N8CP@1224|Proteobacteria,42NR3@68525|delta/epsilon subdivisions,2YNNC@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	Hemerythrin	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
TLS2_k127_5063736_4	497964.CfE428DRAFT_3794	1.342e-99	345.0	COG4251@1|root,COG4251@2|Bacteria,46UHX@74201|Verrucomicrobia	74201|Verrucomicrobia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
TLS2_k127_5063736_8	1267535.KB906767_gene899	1.946e-29	123.0	COG0457@1|root,COG3063@1|root,COG0457@2|Bacteria,COG3063@2|Bacteria,3Y6CI@57723|Acidobacteria	57723|Acidobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
TLS2_k127_5063975_3	234267.Acid_6992	7.958e-56	198.0	COG2183@1|root,COG2183@2|Bacteria,3Y2QM@57723|Acidobacteria	57723|Acidobacteria	K	SMART Resolvase, RNase H domain protein fold	-	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
TLS2_k127_5063975_1	234267.Acid_2148	5.616e-173	554.0	COG0612@1|root,COG0612@2|Bacteria,3Y77X@57723|Acidobacteria	57723|Acidobacteria	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_5063975_2	234267.Acid_2149	5.63e-130	429.0	COG0612@1|root,COG0612@2|Bacteria,3Y79G@57723|Acidobacteria	57723|Acidobacteria	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_5063975_0	1267535.KB906767_gene914	2.583e-201	634.0	COG0304@1|root,COG0304@2|Bacteria,3Y43C@57723|Acidobacteria,2JMFI@204432|Acidobacteriia	204432|Acidobacteriia	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS2_k127_5066398_2	1267535.KB906767_gene3468	1.985e-106	351.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,3Y2RB@57723|Acidobacteria,2JIRW@204432|Acidobacteriia	204432|Acidobacteriia	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1,ECH_2
TLS2_k127_5066398_0	234267.Acid_5545	9.208e-176	557.0	COG0183@1|root,COG0183@2|Bacteria	2|Bacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_5066398_1	1396141.BATP01000058_gene2050	2.238e-158	510.0	COG5297@1|root,COG5297@2|Bacteria,46XAP@74201|Verrucomicrobia,2IV7K@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Protein of unknown function (DUF1593)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1593
TLS2_k127_5066398_4	179408.Osc7112_0395	3.638e-64	225.0	COG0262@1|root,COG0262@2|Bacteria,1G4ME@1117|Cyanobacteria,1HAT3@1150|Oscillatoriales	1117|Cyanobacteria	H	dihydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_5066398_3	1340493.JNIF01000004_gene777	4.748e-94	320.0	COG4654@1|root,COG4654@2|Bacteria	2|Bacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PSCyt1,PSCyt2,PSD1
TLS2_k127_5067258_1	1146883.BLASA_0285	5.514e-164	522.0	COG1257@1|root,COG1257@2|Bacteria,2GP3P@201174|Actinobacteria	201174|Actinobacteria	I	reductase	mvaA	-	1.1.1.34	ko:K00021	ko00900,ko01100,ko01110,ko01130,ko04152,ko04976,map00900,map01100,map01110,map01130,map04152,map04976	M00095	R02082	RC00004,RC00644	ko00000,ko00001,ko00002,ko01000	-	-	-	HMG-CoA_red
TLS2_k127_5067258_2	1267533.KB906734_gene3884	7.164e-140	455.0	COG2025@1|root,COG2025@2|Bacteria,3Y3JE@57723|Acidobacteria,2JM9U@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein FAD-binding domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TLS2_k127_5067258_3	1267533.KB906734_gene3885	1.136e-110	368.0	COG2086@1|root,COG2086@2|Bacteria,3Y2PD@57723|Acidobacteria,2JK7K@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
TLS2_k127_5067258_0	1267533.KB906734_gene3886	1.277e-166	528.0	COG0247@1|root,COG0247@2|Bacteria,3Y3K8@57723|Acidobacteria,2JKGH@204432|Acidobacteriia	204432|Acidobacteriia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
TLS2_k127_5079674_2	1267535.KB906767_gene3597	2.293e-59	217.0	COG4775@1|root,COG4775@2|Bacteria,3Y2RF@57723|Acidobacteria,2JHK5@204432|Acidobacteriia	204432|Acidobacteriia	M	surface antigen variable number	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
TLS2_k127_5079674_0	234267.Acid_0749	4.097e-131	429.0	COG0476@1|root,COG0476@2|Bacteria,3Y2HZ@57723|Acidobacteria	57723|Acidobacteria	H	MoeZ MoeB domain	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
TLS2_k127_5079674_1	595460.RRSWK_07140	3.52e-107	358.0	COG1520@1|root,COG1520@2|Bacteria,2IXSV@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_5080939_1	536019.Mesop_2764	1.562e-51	184.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,43GR9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
TLS2_k127_5080939_0	472175.EL18_01951	1.962e-170	542.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria,43I82@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	TRAP transporter solute receptor TAXI family	thyA	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
TLS2_k127_5086369_1	641524.ADICYQ_5476	2.204e-39	153.0	COG1053@1|root,COG1053@2|Bacteria,4NG56@976|Bacteroidetes,47YCZ@768503|Cytophagia	976|Bacteroidetes	C	HI0933-like protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_5086369_0	1403819.BATR01000135_gene4814	1.239e-68	250.0	COG4409@1|root,COG4409@2|Bacteria,46WX2@74201|Verrucomicrobia	74201|Verrucomicrobia	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_5086369_2	1123242.JH636436_gene247	6.155e-28	119.0	COG4409@1|root,COG4409@2|Bacteria,2J1QW@203682|Planctomycetes	203682|Planctomycetes	M	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_5086473_5	935567.JAES01000028_gene2707	5.842e-05	50.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_5086473_4	749414.SBI_02271	2.615e-43	161.0	COG3254@1|root,COG3254@2|Bacteria,2IQ69@201174|Actinobacteria	201174|Actinobacteria	S	L-rhamnose mutarotase	rhaM	-	5.1.3.32	ko:K03534	-	-	R10819	RC00563	ko00000,ko01000	-	-	-	rhaM
TLS2_k127_5086473_2	1340493.JNIF01000004_gene944	1.149e-86	303.0	COG4783@1|root,COG4783@2|Bacteria,3Y6B5@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS2_k127_5086473_1	234267.Acid_4563	6.773e-146	472.0	COG0477@1|root,COG2814@2|Bacteria,3Y3ZZ@57723|Acidobacteria	57723|Acidobacteria	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_5086473_3	234267.Acid_0063	1.62e-64	231.0	COG1540@1|root,COG1540@2|Bacteria	2|Bacteria	S	5-oxoprolinase (ATP-hydrolyzing) activity	ybgL	-	-	ko:K07160	-	-	-	-	ko00000	-	-	-	LamB_YcsF
TLS2_k127_5086473_0	234267.Acid_5844	0.0	1249.0	COG0495@1|root,COG0495@2|Bacteria,3Y37K@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
TLS2_k127_5090906_5	195253.Syn6312_2848	4.034e-75	270.0	COG0671@1|root,COG1572@1|root,COG3209@1|root,COG0671@2|Bacteria,COG1572@2|Bacteria,COG3209@2|Bacteria,1GHH3@1117|Cyanobacteria,1H44C@1129|Synechococcus	1117|Cyanobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,PAP2
TLS2_k127_5090906_8	1121406.JAEX01000003_gene1597	2.172e-17	89.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WPUW@28221|Deltaproteobacteria,2MC6E@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS2_k127_5090906_2	1038860.AXAP01000018_gene3108	5.288e-182	587.0	COG1520@1|root,COG2010@1|root,COG1520@2|Bacteria,COG2010@2|Bacteria,1PIDE@1224|Proteobacteria,2TTS3@28211|Alphaproteobacteria,3JVPI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
TLS2_k127_5090906_6	1267535.KB906767_gene2231	4.254e-64	234.0	COG0457@1|root,COG0457@2|Bacteria	1267535.KB906767_gene2231|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5090906_1	234267.Acid_7435	7.397e-192	612.0	COG1134@1|root,COG1134@2|Bacteria,3Y72D@57723|Acidobacteria	57723|Acidobacteria	GM	Wzt C-terminal domain	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
TLS2_k127_5090906_4	234267.Acid_7436	8.895e-106	358.0	COG2227@1|root,COG3206@1|root,COG2227@2|Bacteria,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K03561,ko:K07011,ko:K20444	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	1.A.30.2.1,4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
TLS2_k127_5090906_0	234267.Acid_7437	3.664e-314	981.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,3Y79C@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
TLS2_k127_5090906_3	234267.Acid_7439	7.116e-117	381.0	COG1215@1|root,COG1215@2|Bacteria,3Y5K6@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_5092472_0	234267.Acid_6059	6.703e-254	791.0	COG4584@1|root,COG4584@2|Bacteria,3Y630@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_5092472_1	234267.Acid_7619	6.332e-131	422.0	COG1484@1|root,COG1484@2|Bacteria,3Y7G6@57723|Acidobacteria	2|Bacteria	L	PFAM IstB domain protein ATP-binding protein	istB3	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21,IstB_IS21_ATP
TLS2_k127_5092472_2	266835.14026068	2.608e-15	75.0	COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2TRKD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
TLS2_k127_51113_6	1340493.JNIF01000004_gene855	1.585e-07	62.0	COG0642@1|root,COG2205@2|Bacteria,3Y4AU@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_51113_4	234267.Acid_3832	2.564e-31	128.0	2CIIF@1|root,30NI8@2|Bacteria,3Y8FJ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_51113_1	1267535.KB906767_gene3222	4.59e-100	330.0	COG1595@1|root,COG1595@2|Bacteria,3Y6TU@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_51113_3	1267535.KB906767_gene3221	1.725e-50	181.0	COG0316@1|root,COG0316@2|Bacteria,3Y4ZB@57723|Acidobacteria,2JJEX@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the HesB IscA family	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_biosyn
TLS2_k127_51113_0	234267.Acid_7426	5.094e-111	366.0	COG2103@1|root,COG2103@2|Bacteria,3Y378@57723|Acidobacteria	57723|Acidobacteria	S	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	-	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS_2
TLS2_k127_51113_2	1340493.JNIF01000003_gene1660	1.216e-78	269.0	COG0766@1|root,COG0766@2|Bacteria,3Y2IC@57723|Acidobacteria	57723|Acidobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TLS2_k127_5114703_4	234267.Acid_6599	2.632e-78	278.0	COG0577@1|root,COG0577@2|Bacteria,3Y7DQ@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_5114703_6	234267.Acid_1445	1.003e-60	220.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c,HisKA,PAS_4,PAS_9,dCache_1
TLS2_k127_5114703_5	234267.Acid_1446	1.133e-62	218.0	COG3437@1|root,COG3437@2|Bacteria,3Y907@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,Response_reg
TLS2_k127_5114703_3	234267.Acid_0123	8.647e-80	271.0	COG2096@1|root,COG2096@2|Bacteria,3Y77H@57723|Acidobacteria	57723|Acidobacteria	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
TLS2_k127_5114703_0	234267.Acid_0508	1.668e-189	606.0	COG0497@1|root,COG0497@2|Bacteria,3Y2J4@57723|Acidobacteria	57723|Acidobacteria	L	May be involved in recombinational repair of damaged DNA	-	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
TLS2_k127_5114703_1	1173026.Glo7428_2695	3.421e-129	443.0	COG2303@1|root,COG2303@2|Bacteria,1G31H@1117|Cyanobacteria	1117|Cyanobacteria	E	Gmc oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GIDA,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
TLS2_k127_5114703_2	1173024.KI912154_gene1138	6.079e-101	347.0	COG2244@1|root,COG2244@2|Bacteria,1G2NK@1117|Cyanobacteria	1117|Cyanobacteria	S	Membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3,Polysacc_synt_C
TLS2_k127_5114703_7	1142394.PSMK_18180	1.341e-57	216.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	walM	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_5114703_8	1340493.JNIF01000004_gene318	1.773e-30	128.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat
TLS2_k127_5122405_6	234267.Acid_7603	2.877e-18	88.0	2AG8X@1|root,316EB@2|Bacteria,3Y75Y@57723|Acidobacteria	57723|Acidobacteria	S	Plasmid encoded RepA protein	-	-	-	-	-	-	-	-	-	-	-	-	RepA_C
TLS2_k127_5122405_1	1288494.EBAPG3_11800	3.375e-118	387.0	2C0NW@1|root,2ZA4A@2|Bacteria,1R3I4@1224|Proteobacteria,2WC0U@28216|Betaproteobacteria,3744K@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5122405_5	247490.KSU1_D0279	2.13e-20	92.0	2DCMV@1|root,2ZENY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5122405_2	1288494.EBAPG3_11780	6.704e-102	340.0	COG1404@1|root,COG1404@2|Bacteria,1PWF5@1224|Proteobacteria,2WBZM@28216|Betaproteobacteria,3742I@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS2_k127_5122405_4	1366050.N234_10140	6.11e-46	179.0	COG1680@1|root,COG2815@1|root,COG1680@2|Bacteria,COG2815@2|Bacteria,1RIP7@1224|Proteobacteria,2W73Q@28216|Betaproteobacteria,1KDQJ@119060|Burkholderiaceae	28216|Betaproteobacteria	V	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
TLS2_k127_5122405_0	234267.Acid_1108	9.5e-128	436.0	COG0666@1|root,COG1657@1|root,COG0666@2|Bacteria,COG1657@2|Bacteria,3Y83C@57723|Acidobacteria	2|Bacteria	I	Ankyrin repeats (many copies)	-	-	3.5.1.81	ko:K06015,ko:K06867,ko:K06886	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,Prenyltrans,SQHop_cyclase_C,YkuD
TLS2_k127_5122405_3	1265503.KB905170_gene176	2.028e-50	203.0	COG0642@1|root,COG2199@1|root,COG3292@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,2Q7NV@267889|Colwelliaceae	1236|Gammaproteobacteria	T	Two component regulator propeller	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	7TMR-DISM_7TM,GGDEF,HAMP,HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y,dCache_1
TLS2_k127_5123117_5	1123073.KB899241_gene3142	5.277e-168	538.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1RYFT@1236|Gammaproteobacteria,1X97Z@135614|Xanthomonadales	135614|Xanthomonadales	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_5123117_2	1267535.KB906767_gene5100	0.0	1027.0	COG1166@1|root,COG1166@2|Bacteria,3Y449@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
TLS2_k127_5123117_0	1340493.JNIF01000003_gene3464	0.0	1594.0	COG1629@1|root,COG4771@2|Bacteria,3Y77Q@57723|Acidobacteria	57723|Acidobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_5123117_7	234267.Acid_3528	5.032e-147	470.0	COG0412@1|root,COG0412@2|Bacteria,3Y4P0@57723|Acidobacteria	57723|Acidobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TLS2_k127_5123117_13	1411123.JQNH01000001_gene1051	2.267e-40	153.0	COG0346@1|root,COG0346@2|Bacteria,1RIN8@1224|Proteobacteria,2U9WM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_5123117_11	1267533.KB906737_gene1760	4.107e-52	194.0	COG0590@1|root,COG0590@2|Bacteria	2|Bacteria	FJ	tRNA wobble adenosine to inosine editing	tadA	-	3.5.4.3,3.5.4.33	ko:K01487,ko:K11991	ko00230,ko01100,map00230,map01100	-	R01676,R10223	RC00204,RC00477	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
TLS2_k127_5123117_8	1121406.JAEX01000007_gene2379	5.045e-139	460.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,42NHC@68525|delta/epsilon subdivisions,2WJQJ@28221|Deltaproteobacteria,2MGAK@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Alanine dehydrogenase/PNT, N-terminal domain	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
TLS2_k127_5123117_14	1121406.JAEX01000007_gene2380	3.885e-36	140.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,42WKN@68525|delta/epsilon subdivisions,2WRXH@28221|Deltaproteobacteria,2MCPQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
TLS2_k127_5123117_4	314230.DSM3645_07186	8.453e-174	556.0	COG1282@1|root,COG1282@2|Bacteria,2IYIA@203682|Planctomycetes	203682|Planctomycetes	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
TLS2_k127_5123117_3	234267.Acid_0435	1.627e-184	589.0	COG0277@1|root,COG0277@2|Bacteria,3Y6VC@57723|Acidobacteria	57723|Acidobacteria	C	D-arabinono-1,4-lactone oxidase	-	-	-	-	-	-	-	-	-	-	-	-	ALO,FAD_binding_4
TLS2_k127_5123117_10	1340493.JNIF01000003_gene2851	2.05e-86	298.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132,HEAT_2
TLS2_k127_5123117_15	1340493.JNIF01000003_gene2581	1.088e-33	135.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	tlpA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin,Thioredoxin_8
TLS2_k127_5123117_6	1267535.KB906767_gene4340	4.079e-165	525.0	COG0182@1|root,COG0182@2|Bacteria,3Y2TR@57723|Acidobacteria,2JHZX@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
TLS2_k127_5123117_12	234267.Acid_7261	6.295e-42	167.0	COG1266@1|root,COG1266@2|Bacteria,3Y54S@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_5123117_9	234267.Acid_7262	6.357e-131	428.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5123117_1	234267.Acid_7263	0.0	1146.0	COG0178@1|root,COG0178@2|Bacteria,3Y3G9@57723|Acidobacteria	57723|Acidobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_5123878_2	234267.Acid_0229	5.98e-53	210.0	COG2890@1|root,COG2890@2|Bacteria,3Y8Q3@57723|Acidobacteria	57723|Acidobacteria	J	Pfam:Methyltransf_26	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5123878_1	234267.Acid_0229	2.513e-67	253.0	COG2890@1|root,COG2890@2|Bacteria,3Y8Q3@57723|Acidobacteria	57723|Acidobacteria	J	Pfam:Methyltransf_26	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5123878_0	234267.Acid_0227	1.184e-106	351.0	COG3522@1|root,COG3522@2|Bacteria,3Y3ZF@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE	-	-	-	ko:K11893	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_VasE
TLS2_k127_5125538_1	1267535.KB906767_gene200	1.342e-42	161.0	COG1959@1|root,COG1959@2|Bacteria,3Y4X0@57723|Acidobacteria,2JJEV@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TLS2_k127_5125538_0	1267535.KB906767_gene199	1.122e-213	675.0	COG1104@1|root,COG1104@2|Bacteria,3Y3CG@57723|Acidobacteria,2JI55@204432|Acidobacteriia	204432|Acidobacteriia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS2_k127_5125538_2	1267535.KB906767_gene198	8.188e-26	107.0	COG0822@1|root,COG0822@2|Bacteria,3Y4B9@57723|Acidobacteria,2JJ45@204432|Acidobacteriia	204432|Acidobacteriia	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS2_k127_5127020_9	639030.JHVA01000001_gene2666	7.61e-17	86.0	COG1502@1|root,COG1502@2|Bacteria,3Y2GD@57723|Acidobacteria,2JKZ7@204432|Acidobacteriia	204432|Acidobacteriia	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
TLS2_k127_5127020_5	1267535.KB906767_gene5523	1.202e-95	320.0	COG0106@1|root,COG0106@2|Bacteria,3Y4TG@57723|Acidobacteria,2JKDT@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the HisA HisF family	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS2_k127_5127020_3	1340493.JNIF01000003_gene1905	4.822e-127	413.0	COG0107@1|root,COG0107@2|Bacteria,3Y2MG@57723|Acidobacteria	57723|Acidobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS2_k127_5127020_6	1267535.KB906767_gene5525	6.766e-71	245.0	COG0118@1|root,COG0118@2|Bacteria,3Y5DZ@57723|Acidobacteria,2JKDU@204432|Acidobacteriia	204432|Acidobacteriia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS2_k127_5127020_4	234267.Acid_3852	1.756e-99	327.0	COG0131@1|root,COG0131@2|Bacteria,3Y3DU@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
TLS2_k127_5127020_7	1267535.KB906767_gene5528	2.898e-65	232.0	COG0546@1|root,COG0546@2|Bacteria,3Y7JG@57723|Acidobacteria	57723|Acidobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K11777	-	-	-	-	ko00000	-	-	-	HAD_2
TLS2_k127_5127020_2	1340493.JNIF01000003_gene1901	5.364e-142	458.0	COG0079@1|root,COG0079@2|Bacteria,3Y3M6@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_5127020_0	234267.Acid_3855	6.349e-170	542.0	COG0141@1|root,COG0141@2|Bacteria,3Y2N7@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
TLS2_k127_5127020_1	234267.Acid_3856	4.223e-153	489.0	COG0040@1|root,COG0040@2|Bacteria,3Y31Q@57723|Acidobacteria	57723|Acidobacteria	E	ATP phosphoribosyltransferase	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
TLS2_k127_5127020_8	234267.Acid_3857	2.062e-29	118.0	COG0139@1|root,COG0139@2|Bacteria,3Y4SN@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	-	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
TLS2_k127_5148926_1	1340493.JNIF01000003_gene3446	9.926e-223	700.0	COG2960@1|root,COG2960@2|Bacteria	2|Bacteria	M	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
TLS2_k127_5148926_0	1340493.JNIF01000003_gene3445	2.286e-253	796.0	COG0551@1|root,COG2010@1|root,COG0551@2|Bacteria,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5
TLS2_k127_5148926_2	118173.KB235914_gene3750	4.158e-38	151.0	2DQHJ@1|root,336X1@2|Bacteria,1GQW2@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5166342_3	1120965.AUBV01000010_gene2835	8.884e-25	109.0	COG1770@1|root,COG1770@2|Bacteria,4NEQS@976|Bacteroidetes,47KWW@768503|Cytophagia	976|Bacteroidetes	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_5166342_4	452637.Oter_1875	2.613e-16	84.0	COG0577@1|root,COG0577@2|Bacteria,46TJI@74201|Verrucomicrobia	74201|Verrucomicrobia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_5166342_1	595460.RRSWK_04461	8.77e-97	332.0	COG0673@1|root,COG0673@2|Bacteria,2IXRR@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_5166342_2	1267535.KB906767_gene420	6.76e-32	134.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_5166342_0	1267535.KB906767_gene5141	1.655e-104	366.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria	57723|Acidobacteria	KU	WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_5170302_4	1340493.JNIF01000003_gene2618	2.136e-49	184.0	2DQHJ@1|root,336X1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5170302_1	1267535.KB906767_gene1551	3.612e-118	386.0	COG0179@1|root,COG0179@2|Bacteria,3Y4QZ@57723|Acidobacteria,2JP1G@204432|Acidobacteriia	204432|Acidobacteriia	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
TLS2_k127_5170302_2	234267.Acid_4969	4.415e-113	372.0	COG1028@1|root,COG1028@2|Bacteria,3Y3CD@57723|Acidobacteria	57723|Acidobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_5170302_0	234267.Acid_0368	1.525e-193	612.0	COG0436@1|root,COG0436@2|Bacteria,3Y3DG@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS2_k127_5170302_3	1267535.KB906767_gene5217	1.898e-82	278.0	COG0183@1|root,COG0183@2|Bacteria,3Y7RP@57723|Acidobacteria	57723|Acidobacteria	I	Thiolase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_5170332_1	234267.Acid_5848	6.55e-98	342.0	COG2982@1|root,COG2982@2|Bacteria,3Y3Z4@57723|Acidobacteria	57723|Acidobacteria	M	AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
TLS2_k127_5170332_2	234267.Acid_2709	4.719e-32	137.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	damX	-	-	ko:K03112	-	-	-	-	ko00000	-	-	-	AAA_10,SPOR
TLS2_k127_5170332_0	1267535.KB906767_gene299	5.599e-112	385.0	COG0741@1|root,COG1729@1|root,COG0741@2|Bacteria,COG1729@2|Bacteria,3Y2UJ@57723|Acidobacteria,2JIUE@204432|Acidobacteriia	204432|Acidobacteriia	M	Transglycosylase SLT domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_16,YfiO
TLS2_k127_5170332_3	448385.sce3341	0.000607	47.0	COG4319@1|root,COG4319@2|Bacteria,1NMYE@1224|Proteobacteria,434ER@68525|delta/epsilon subdivisions,2WYS4@28221|Deltaproteobacteria,2Z0GJ@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_5172853_3	1340493.JNIF01000004_gene819	8.59e-41	162.0	COG4654@1|root,COG4654@2|Bacteria	2|Bacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_5172853_1	1340493.JNIF01000003_gene4134	2.704e-272	858.0	COG4654@1|root,COG4654@2|Bacteria	2|Bacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PSCyt1,PSCyt2,PSD1
TLS2_k127_5172853_2	1340493.JNIF01000003_gene3900	5.898e-216	676.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	4.2.1.90	ko:K12661	ko00051,ko01120,map00051,map01120	-	R03774	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_5172853_0	1340493.JNIF01000003_gene2320	1.148e-309	987.0	COG1629@1|root,COG4771@2|Bacteria	1340493.JNIF01000003_gene2320|-	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5172853_4	7213.XP_004520706.1	5.026e-39	147.0	COG1454@1|root,KOG3857@2759|Eukaryota,38EFC@33154|Opisthokonta,3BCTE@33208|Metazoa,3CT5M@33213|Bilateria,41YGY@6656|Arthropoda,3SJKG@50557|Insecta,45093@7147|Diptera	33208|Metazoa	C	Metal ion binding. It is involved in the biological process described with oxidation-reduction process	ADHFE1	GO:0003674,GO:0003824,GO:0004022,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006103,GO:0006520,GO:0006536,GO:0006538,GO:0006539,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0047988,GO:0051186,GO:0055114,GO:0070013,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.1.99.24	ko:K11173	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
TLS2_k127_5173621_0	1340493.JNIF01000003_gene1819	7.617e-184	621.0	COG2911@1|root,COG4775@1|root,COG2911@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K07277,ko:K09800	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	AsmA_2,Bac_surface_Ag,DUF748,POTRA,TamB
TLS2_k127_5173621_9	1340493.JNIF01000003_gene1818	2.955e-32	132.0	COG0457@1|root,COG0457@2|Bacteria	1340493.JNIF01000003_gene1818|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5173621_1	754035.Mesau_04079	8.7e-91	313.0	COG0834@1|root,COG0834@2|Bacteria,1MWWZ@1224|Proteobacteria,2TU2F@28211|Alphaproteobacteria,43JJK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	ET	PFAM extracellular solute-binding protein, family 3	-	-	-	ko:K16254	ko00680,ko01120,map00680,map01120	-	-	-	ko00000,ko00001	-	-	-	SBP_bac_3
TLS2_k127_5173621_6	234267.Acid_4680	6.794e-59	208.0	COG3189@1|root,COG3189@2|Bacteria,3Y86R@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
TLS2_k127_5173621_2	1448860.BBJO01000034_gene550	8.392e-85	289.0	COG0596@1|root,arCOG01648@2157|Archaea,2XSWV@28890|Euryarchaeota,23T2R@183963|Halobacteria	183963|Halobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_5173621_3	1340493.JNIF01000003_gene4444	5.954e-81	282.0	COG0609@1|root,COG0609@2|Bacteria,3Y7KJ@57723|Acidobacteria	57723|Acidobacteria	P	FecCD transport family	-	-	-	-	-	-	-	-	-	-	-	-	FecCD
TLS2_k127_5173621_7	278963.ATWD01000001_gene1754	9.537e-55	204.0	COG1120@1|root,COG1120@2|Bacteria,3Y8BQ@57723|Acidobacteria	57723|Acidobacteria	HP	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_5173621_8	278963.ATWD01000001_gene1753	1.222e-48	188.0	COG0614@1|root,COG0614@2|Bacteria,3Y7Z8@57723|Acidobacteria	57723|Acidobacteria	P	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_2
TLS2_k127_5173621_5	1340493.JNIF01000003_gene4441	7.381e-77	271.0	COG0079@1|root,COG0079@2|Bacteria,3Y68T@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
TLS2_k127_5173621_10	1536769.P40081_07465	8.042e-23	102.0	COG1270@1|root,COG1270@2|Bacteria,1TQ3X@1239|Firmicutes,4HA48@91061|Bacilli,26QM4@186822|Paenibacillaceae	91061|Bacilli	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
TLS2_k127_5174443_0	1267535.KB906767_gene4707	1.13e-278	867.0	COG2183@1|root,COG2183@2|Bacteria,3Y2QM@57723|Acidobacteria,2JIB9@204432|Acidobacteriia	204432|Acidobacteriia	K	RNA binding	-	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
TLS2_k127_5183332_2	243090.RB13132	3.324e-14	72.0	COG4102@1|root,COG4102@2|Bacteria,2IXKP@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_5183332_0	1267535.KB906767_gene4498	2.392e-145	467.0	COG0673@1|root,COG0673@2|Bacteria,3Y6Z2@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_5183332_1	1123248.KB893326_gene1247	3.659e-87	295.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231,Hemerythrin,Rieske
TLS2_k127_5185325_0	234267.Acid_0019	1.784e-215	681.0	2EY4D@1|root,33RD9@2|Bacteria,3Y6DM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5185325_1	234267.Acid_1802	1.151e-109	360.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,PMT_2
TLS2_k127_5187184_3	1340493.JNIF01000003_gene2431	5.784e-125	413.0	COG1524@1|root,COG1524@2|Bacteria,3Y4MJ@57723|Acidobacteria	57723|Acidobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_5187184_0	234267.Acid_7763	0.0	1019.0	COG1200@1|root,COG1200@2|Bacteria,3Y31Z@57723|Acidobacteria	57723|Acidobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
TLS2_k127_5187184_4	1267535.KB906767_gene4356	1.456e-59	214.0	COG0742@1|root,COG0742@2|Bacteria,3Y4K0@57723|Acidobacteria,2JJDW@204432|Acidobacteriia	204432|Acidobacteriia	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
TLS2_k127_5187184_2	641524.ADICYQ_2511	2.149e-132	441.0	2DBQR@1|root,2ZAG2@2|Bacteria,4NK84@976|Bacteroidetes,47NS0@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2
TLS2_k127_5187184_1	1267535.KB906767_gene2157	1.99e-224	709.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y358@57723|Acidobacteria,2JIID@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,SpoIIE
TLS2_k127_5187184_5	234267.Acid_2205	1.714e-53	192.0	COG0274@1|root,COG0274@2|Bacteria,3Y2Q4@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS2_k127_5188361_3	338969.Rfer_0485	2.495e-19	96.0	COG4319@1|root,COG4319@2|Bacteria,1RGSM@1224|Proteobacteria,2VYTU@28216|Betaproteobacteria,4AG0E@80864|Comamonadaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_5188361_4	234267.Acid_2710	2.877e-08	61.0	COG0741@1|root,COG1729@1|root,COG0741@2|Bacteria,COG1729@2|Bacteria,3Y2UJ@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Lytic transglycosylase catalytic	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_16,YfiO
TLS2_k127_5188361_2	1267535.KB906767_gene680	5.335e-22	99.0	COG1983@1|root,COG1983@2|Bacteria,3Y5HA@57723|Acidobacteria	57723|Acidobacteria	KT	Phage shock protein C, PspC	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC,zinc_ribbon_2
TLS2_k127_5188361_0	1123248.KB893386_gene1937	1.8e-36	143.0	COG3695@1|root,COG3695@2|Bacteria,4NZHS@976|Bacteroidetes,1IZ68@117747|Sphingobacteriia	976|Bacteroidetes	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DNA_binding_1
TLS2_k127_5188361_1	1396.DJ87_2869	6.374e-34	133.0	COG3576@1|root,COG3576@2|Bacteria,1UZ02@1239|Firmicutes,4HEN8@91061|Bacilli,1ZC4B@1386|Bacillus	91061|Bacilli	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
TLS2_k127_5189843_0	234267.Acid_4014	9.036e-72	256.0	COG0673@1|root,COG0673@2|Bacteria,3Y4KS@57723|Acidobacteria	2|Bacteria	S	PFAM oxidoreductase domain protein	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_5189843_1	497964.CfE428DRAFT_0811	2.789e-26	114.0	COG0673@1|root,COG0673@2|Bacteria,46SJ7@74201|Verrucomicrobia	74201|Verrucomicrobia	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_5199104_4	1340493.JNIF01000003_gene4244	3.998e-09	60.0	2ANK7@1|root,31DJB@2|Bacteria,3Y7J7@57723|Acidobacteria	57723|Acidobacteria	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
TLS2_k127_5199104_1	452637.Oter_0134	9.152e-212	674.0	COG2730@1|root,COG2730@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase,DUF4038,DUF5060,Glyco_hydro_115
TLS2_k127_5199104_2	1123242.JH636434_gene5302	2.448e-101	351.0	COG1520@1|root,COG1520@2|Bacteria,2IYRB@203682|Planctomycetes	1123242.JH636434_gene5302|-	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5199104_0	1267535.KB906767_gene3020	2.053e-251	786.0	COG0457@1|root,COG0457@2|Bacteria,3Y3WM@57723|Acidobacteria	57723|Acidobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS2_k127_5199104_3	234267.Acid_3491	3.79e-54	204.0	COG0457@1|root,COG0457@2|Bacteria,3Y8AI@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
TLS2_k127_5199104_5	234267.Acid_3494	2.287e-05	46.0	COG0457@1|root,COG0457@2|Bacteria,3Y6B2@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
TLS2_k127_5210976_0	1192034.CAP_1902	8.995e-153	491.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,42QCJ@68525|delta/epsilon subdivisions,2WKE7@28221|Deltaproteobacteria,2YUF8@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	DUF547,Glyco_hydro_15
TLS2_k127_5210976_1	1267535.KB906767_gene5199	6.891e-133	430.0	COG1082@1|root,COG1082@2|Bacteria,3Y78R@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_5211648_3	518766.Rmar_0629	2.592e-129	427.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,4NERT@976|Bacteroidetes,1FJ3R@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	MU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	BSP,Bac_surface_Ag,PD40
TLS2_k127_5211648_4	1340493.JNIF01000003_gene3435	2.268e-126	413.0	COG1312@1|root,COG1312@2|Bacteria,3Y6UB@57723|Acidobacteria	57723|Acidobacteria	G	D-mannonate dehydratase (UxuA)	-	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
TLS2_k127_5211648_1	234267.Acid_1183	2.762e-192	628.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,3Y6RM@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Pyrrolo-quinoline quinone	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
TLS2_k127_5211648_5	1123242.JH636434_gene4859	8.353e-72	251.0	COG0730@1|root,COG0730@2|Bacteria,2IZGZ@203682|Planctomycetes	203682|Planctomycetes	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_5211648_2	234267.Acid_7084	5.655e-190	603.0	COG0524@1|root,COG0524@2|Bacteria,3Y3DE@57723|Acidobacteria	57723|Acidobacteria	G	PfkB domain protein	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
TLS2_k127_5211648_0	1267535.KB906767_gene772	4.3e-264	818.0	COG0362@1|root,COG0362@2|Bacteria,3Y990@57723|Acidobacteria,2JP1Q@204432|Acidobacteriia	204432|Acidobacteriia	G	6-phosphogluconate dehydrogenase, C-terminal domain	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
TLS2_k127_5211648_6	204669.Acid345_0637	9.482e-63	219.0	COG1680@1|root,COG1680@2|Bacteria,3Y7EG@57723|Acidobacteria,2JNJ4@204432|Acidobacteriia	204432|Acidobacteriia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_5221840_6	234267.Acid_0293	1.492e-63	231.0	COG0251@1|root,COG0251@2|Bacteria,3Y810@57723|Acidobacteria	57723|Acidobacteria	J	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5221840_2	234267.Acid_0291	7.428e-147	479.0	COG1167@1|root,COG1167@2|Bacteria,3Y4RE@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
TLS2_k127_5221840_1	1267535.KB906767_gene820	1.729e-149	477.0	COG0214@1|root,COG0214@2|Bacteria,3Y3ST@57723|Acidobacteria,2JKN5@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the PdxS SNZ family	-	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
TLS2_k127_5221840_5	1267535.KB906767_gene819	3.479e-70	242.0	COG0311@1|root,COG0311@2|Bacteria,3Y4GN@57723|Acidobacteria,2JJ3V@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
TLS2_k127_5221840_8	1340493.JNIF01000003_gene4617	2.894e-24	109.0	COG0394@1|root,COG0394@2|Bacteria,3Y8RC@57723|Acidobacteria	57723|Acidobacteria	T	Low molecular weight phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	LMWPc
TLS2_k127_5221840_7	330214.NIDE4311	7.546e-36	141.0	COG1585@1|root,COG1585@2|Bacteria	2|Bacteria	OU	cellular response to DNA damage stimulus	-	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
TLS2_k127_5221840_3	290397.Adeh_0881	1.971e-133	432.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WKYT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
TLS2_k127_5221840_0	1267535.KB906767_gene2306	0.0	1346.0	COG1629@1|root,COG1629@2|Bacteria,3Y9AK@57723|Acidobacteria	57723|Acidobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_5221840_4	208439.AJAP_25450	1.016e-99	339.0	COG2850@1|root,COG2850@2|Bacteria,2GMR2@201174|Actinobacteria,4DYRP@85010|Pseudonocardiales	201174|Actinobacteria	S	Cupin superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_4
TLS2_k127_5221840_10	1155714.KB891999_gene197	0.0004132	44.0	COG4759@1|root,COG4759@2|Bacteria,2GRSQ@201174|Actinobacteria	201174|Actinobacteria	O	protein conserved in bacteria containing thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Suc_Fer-like
TLS2_k127_522346_0	1267535.KB906767_gene1964	2.857e-128	419.0	2AG8X@1|root,316EB@2|Bacteria,3Y75Y@57723|Acidobacteria,2JNUP@204432|Acidobacteriia	204432|Acidobacteriia	S	Plasmid encoded RepA protein	-	-	-	-	-	-	-	-	-	-	-	-	RepA_C
TLS2_k127_522346_1	411464.DESPIG_01955	1.192e-33	133.0	COG4737@1|root,COG4737@2|Bacteria,1N7N5@1224|Proteobacteria,42WVI@68525|delta/epsilon subdivisions,2WT2D@28221|Deltaproteobacteria,2MCSK@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	RelE toxin of RelE / RelB toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	RelE
TLS2_k127_522346_2	794846.AJQU01000105_gene2925	9.981e-21	95.0	COG2944@1|root,COG2944@2|Bacteria,1PT1Q@1224|Proteobacteria,2VCXF@28211|Alphaproteobacteria,4BGXM@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Helix-turn-helix domain	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,HTH_31,MqsA_antitoxin
TLS2_k127_522346_3	1267535.KB906767_gene2040	1.602e-08	57.0	2CGNP@1|root,32S4A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5223868_6	1340493.JNIF01000003_gene3080	3.135e-15	78.0	COG0457@1|root,COG0789@1|root,COG0457@2|Bacteria,COG0789@2|Bacteria,3Y3EM@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TPR_11,TPR_16,TPR_2,TPR_8
TLS2_k127_5223868_2	1267535.KB906767_gene2192	1.185e-107	354.0	COG1028@1|root,COG1028@2|Bacteria,3Y2JR@57723|Acidobacteria,2JJ3M@204432|Acidobacteriia	57723|Acidobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_5223868_0	661478.OP10G_3514	1.847e-140	451.0	COG3186@1|root,COG3186@2|Bacteria	2|Bacteria	E	Phenylalanine-4-hydroxylase	phhA	GO:0003674,GO:0003824,GO:0004497,GO:0004505,GO:0006082,GO:0006520,GO:0006558,GO:0006559,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016491,GO:0016705,GO:0016714,GO:0017144,GO:0019439,GO:0019752,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
TLS2_k127_5223868_5	1267533.KB906735_gene4694	6.683e-72	252.0	COG1853@1|root,COG1853@2|Bacteria,3Y51K@57723|Acidobacteria,2JMFE@204432|Acidobacteriia	204432|Acidobacteriia	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TLS2_k127_5223868_4	234267.Acid_4830	5.599e-73	278.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5223868_3	880070.Cycma_5013	3.878e-88	305.0	COG3119@1|root,COG3119@2|Bacteria,4NF21@976|Bacteroidetes,47M38@768503|Cytophagia	976|Bacteroidetes	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme,Phosphodiest,Sulfatase
TLS2_k127_5223868_1	526227.Mesil_3298	1.737e-128	417.0	COG0174@1|root,COG0174@2|Bacteria,1WM8G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
TLS2_k127_5230714_2	234267.Acid_2866	7.389e-06	48.0	2DBU8@1|root,2ZB4S@2|Bacteria,3Y31B@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
TLS2_k127_5230714_1	1340493.JNIF01000004_gene1042	1.4e-108	363.0	2DUZM@1|root,33T72@2|Bacteria,3Y7AK@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5230714_0	762903.Pedsa_2182	6.205e-120	393.0	COG1028@1|root,COG1028@2|Bacteria,4NFDX@976|Bacteroidetes,1IQ4Z@117747|Sphingobacteriia	976|Bacteroidetes	IQ	PFAM Short-chain dehydrogenase reductase SDR	kduD	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
TLS2_k127_5231747_1	1304883.KI912532_gene1181	1.458e-82	282.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,2KV7X@206389|Rhodocyclales	206389|Rhodocyclales	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
TLS2_k127_5231747_3	234267.Acid_6641	6.821e-30	119.0	COG0227@1|root,COG0227@2|Bacteria,3Y5KC@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
TLS2_k127_5231747_5	1123368.AUIS01000006_gene561	1.004e-15	86.0	COG3861@1|root,COG3861@2|Bacteria,1NHME@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF2382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382
TLS2_k127_5231747_6	113355.CM001775_gene2954	1.149e-15	90.0	COG0515@1|root,COG0515@2|Bacteria	113355.CM001775_gene2954|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5231747_2	234267.Acid_6615	5.171e-70	247.0	28KX8@1|root,2ZAD8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5231747_0	1267535.KB906767_gene454	6.257e-113	370.0	COG1082@1|root,COG1082@2|Bacteria,3Y8R7@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_5231747_7	1280947.HY30_02410	1.23e-05	52.0	COG1225@1|root,COG1225@2|Bacteria,1MZN4@1224|Proteobacteria,2UA7Y@28211|Alphaproteobacteria,43XZ6@69657|Hyphomonadaceae	28211|Alphaproteobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_5231747_4	28229.ND2E_2933	1.597e-20	101.0	COG1225@1|root,COG1225@2|Bacteria,1MZN4@1224|Proteobacteria,1SG3M@1236|Gammaproteobacteria,2Q80N@267889|Colwelliaceae	1236|Gammaproteobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_5231747_8	682795.AciX8_3916	9.689e-05	53.0	COG4232@1|root,COG4232@2|Bacteria,3Y5QG@57723|Acidobacteria,2JK1Z@204432|Acidobacteriia	204432|Acidobacteriia	CO	Disulphide bond corrector protein DsbC	-	-	-	-	-	-	-	-	-	-	-	-	DsbC
TLS2_k127_5234342_3	105425.BBPL01000032_gene4627	3.443e-27	115.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,2NEFS@228398|Streptacidiphilus	201174|Actinobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
TLS2_k127_5234342_0	1144275.COCOR_02357	3.707e-210	692.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions,2WN7A@28221|Deltaproteobacteria,2YTZA@29|Myxococcales	28221|Deltaproteobacteria	Q	non-ribosomal peptide synthetase	-	-	-	ko:K16416	ko01052,map01052	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
TLS2_k127_5234342_2	1266925.JHVX01000015_gene232	7.511e-72	249.0	COG2521@1|root,COG2521@2|Bacteria,1PW9E@1224|Proteobacteria,2WBUE@28216|Betaproteobacteria,373TT@32003|Nitrosomonadales	28216|Betaproteobacteria	S	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5234342_5	867903.ThesuDRAFT_01352	1.366e-12	71.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,248VD@186801|Clostridia	186801|Clostridia	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_5234342_1	234267.Acid_7603	6.1e-89	298.0	2AG8X@1|root,316EB@2|Bacteria,3Y75Y@57723|Acidobacteria	57723|Acidobacteria	S	Plasmid encoded RepA protein	-	-	-	-	-	-	-	-	-	-	-	-	RepA_C
TLS2_k127_5234342_6	598467.BrE312_0951	1.514e-11	76.0	COG4849@1|root,COG4849@2|Bacteria,1N4EJ@1224|Proteobacteria,1S4E0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
TLS2_k127_5234342_4	525897.Dbac_0496	3.984e-20	100.0	COG4861@1|root,COG4861@2|Bacteria,1RFGZ@1224|Proteobacteria,43032@68525|delta/epsilon subdivisions,2WVEI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Transcriptional regulator, AbiEi antitoxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_2
TLS2_k127_5238304_1	350058.Mvan_1114	3.083e-35	148.0	COG4974@1|root,COG4974@2|Bacteria,2IBD6@201174|Actinobacteria,236NP@1762|Mycobacteriaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_5238304_0	1229780.BN381_600013	2.131e-40	160.0	COG4974@1|root,COG4974@2|Bacteria,2I9ZX@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_5240228_3	543526.Htur_0708	1.055e-33	136.0	COG0784@1|root,arCOG02589@2157|Archaea,2XVUK@28890|Euryarchaeota,23V7T@183963|Halobacteria	183963|Halobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_5240228_0	1267535.KB906767_gene4763	4.48e-129	426.0	COG0457@1|root,COG0457@2|Bacteria,3Y3JH@57723|Acidobacteria,2JI8K@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
TLS2_k127_5240228_1	234267.Acid_3576	2.156e-121	397.0	COG1600@1|root,COG1600@2|Bacteria,3Y3TQ@57723|Acidobacteria	57723|Acidobacteria	C	Domain of unknown function (DUF1730)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
TLS2_k127_5240228_2	446462.Amir_4952	1.709e-49	186.0	28PTG@1|root,2ZCEQ@2|Bacteria,2IC4B@201174|Actinobacteria,4E1MV@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5240463_0	1265503.KB905181_gene3778	5.661e-79	278.0	COG2200@1|root,COG2200@2|Bacteria,1N299@1224|Proteobacteria,1S1MD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	EAL,Response_reg
TLS2_k127_5240463_1	391038.Bphy_3920	4.233e-30	123.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VKYM@28216|Betaproteobacteria,1K2PS@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	apbA	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
TLS2_k127_5243367_1	1487953.JMKF01000037_gene3199	6.653e-36	141.0	COG0662@1|root,COG0662@2|Bacteria,1G6EN@1117|Cyanobacteria,1HI82@1150|Oscillatoriales	1117|Cyanobacteria	G	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_5243367_0	234267.Acid_7675	2.794e-249	779.0	COG0480@1|root,COG0480@2|Bacteria,3Y2RR@57723|Acidobacteria	57723|Acidobacteria	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_525179_9	886293.Sinac_5713	6.395e-50	183.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,SGL
TLS2_k127_525179_5	472759.Nhal_0820	1.374e-159	509.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1WX09@135613|Chromatiales	135613|Chromatiales	P	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
TLS2_k127_525179_10	234267.Acid_1594	1.525e-44	165.0	COG1725@1|root,COG1725@2|Bacteria,3Y5VN@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
TLS2_k127_525179_6	234267.Acid_1595	4.807e-111	367.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	hflC	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_525179_11	1296415.JACC01000006_gene1516	5.769e-36	146.0	28JNX@1|root,2Z9F0@2|Bacteria,4NJS0@976|Bacteroidetes,1HYGX@117743|Flavobacteriia,2YKFI@290174|Aquimarina	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_525179_3	234267.Acid_2121	3.194e-226	731.0	COG0515@1|root,COG0515@2|Bacteria	234267.Acid_2121|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
TLS2_k127_525179_13	1304883.KI912532_gene1771	6.919e-24	111.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VPGG@28216|Betaproteobacteria,2KYCK@206389|Rhodocyclales	206389|Rhodocyclales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_525179_7	1267535.KB906767_gene4615	5.375e-66	235.0	COG0053@1|root,COG0053@2|Bacteria,3Y6ZG@57723|Acidobacteria	57723|Acidobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TLS2_k127_525179_14	234267.Acid_5390	2.238e-11	65.0	COG0053@1|root,COG0053@2|Bacteria,3Y6ZG@57723|Acidobacteria	57723|Acidobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TLS2_k127_525179_0	1340493.JNIF01000004_gene555	4.227e-310	971.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_525179_2	1340493.JNIF01000004_gene556	3.523e-233	728.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_525179_12	204669.Acid345_1165	3.504e-31	134.0	COG3391@1|root,COG3391@2|Bacteria,3Y2SU@57723|Acidobacteria,2JKB8@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1
TLS2_k127_525179_8	357808.RoseRS_1828	8.856e-66	239.0	COG3408@1|root,COG3408@2|Bacteria,2G8AC@200795|Chloroflexi	200795|Chloroflexi	G	Alkaline and neutral invertase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,Glyco_hydro_100
TLS2_k127_525179_1	314278.NB231_16483	1.526e-289	901.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1X0IP@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	-	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TLS2_k127_525179_4	479434.Sthe_1092	6.401e-214	685.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia	189775|Thermomicrobia	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
TLS2_k127_5252173_2	234267.Acid_0378	1.199e-33	133.0	COG0859@1|root,COG0859@2|Bacteria,3Y7R7@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
TLS2_k127_5252173_0	234267.Acid_3848	7.325e-255	797.0	COG1132@1|root,COG1132@2|Bacteria,3Y32T@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
TLS2_k127_5252173_1	234267.Acid_3847	1.574e-51	188.0	COG1434@1|root,COG1434@2|Bacteria,3Y8M4@57723|Acidobacteria	57723|Acidobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
TLS2_k127_5255654_3	1340493.JNIF01000003_gene4731	1.093e-34	156.0	COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,3Y3S3@57723|Acidobacteria	57723|Acidobacteria	G	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL
TLS2_k127_5255654_8	1385520.N802_10025	0.0001832	56.0	COG0708@1|root,COG0708@2|Bacteria	2|Bacteria	L	double-stranded DNA 3'-5' exodeoxyribonuclease activity	xthA2	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
TLS2_k127_5255654_6	234267.Acid_6577	1.136e-10	76.0	COG1470@1|root,COG3210@1|root,COG1470@2|Bacteria,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,He_PIG,PATR,SLH
TLS2_k127_5255654_7	290400.Jann_1557	1.713e-06	63.0	COG2340@1|root,COG5549@1|root,COG2340@2|Bacteria,COG5549@2|Bacteria,1R62B@1224|Proteobacteria,2U3MK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF4214
TLS2_k127_5255654_2	1340493.JNIF01000003_gene3903	3.774e-223	700.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_5255654_1	1340493.JNIF01000003_gene3902	8.281e-289	914.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_5255654_5	234267.Acid_4591	1.675e-22	106.0	COG2318@1|root,COG2318@2|Bacteria,3Y501@57723|Acidobacteria	57723|Acidobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_5255654_0	1267535.KB906767_gene1150	0.0	1039.0	COG1523@1|root,COG1523@2|Bacteria,3Y3YA@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS2_k127_5255654_4	926566.Terro_0856	6.571e-29	117.0	COG3280@1|root,COG3280@2|Bacteria,3Y2QG@57723|Acidobacteria,2JIFT@204432|Acidobacteriia	204432|Acidobacteriia	G	TIGRFAM Malto-oligosyltrehalose synthase	-	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
TLS2_k127_5256689_2	1267534.KB906757_gene1076	1.804e-27	116.0	COG0457@1|root,COG0457@2|Bacteria	1267534.KB906757_gene1076|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5256689_0	639030.JHVA01000001_gene945	1.658e-191	618.0	COG3533@1|root,COG3533@2|Bacteria,3Y7GP@57723|Acidobacteria,2JMSH@204432|Acidobacteriia	204432|Acidobacteriia	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
TLS2_k127_5256689_1	1267535.KB906767_gene3617	8.123e-63	234.0	COG0457@1|root,COG0457@2|Bacteria,3Y6XJ@57723|Acidobacteria,2JK9B@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8
TLS2_k127_5257102_2	1123278.KB893615_gene5179	7.565e-15	85.0	COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,4NNEF@976|Bacteroidetes,47PBP@768503|Cytophagia	976|Bacteroidetes	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
TLS2_k127_5257102_3	234267.Acid_2023	4.907e-06	58.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM9_1,CHB_HEX_C_1,CarboxypepD_reg,DUF11,Kelch_1,NPCBM_assoc,OmpA,Pectate_lyase_3,SLH,VCBS
TLS2_k127_5257102_1	1267535.KB906767_gene3771	1.001e-178	571.0	COG3119@1|root,COG3119@2|Bacteria,3Y3PF@57723|Acidobacteria,2JIZB@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_5257102_0	1267535.KB906767_gene1169	1.237e-222	702.0	COG1502@1|root,COG1502@2|Bacteria,3Y2GD@57723|Acidobacteria	57723|Acidobacteria	I	PLD-like domain	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
TLS2_k127_5261727_5	1184609.KILIM_084_00200	1.884e-12	72.0	COG1848@1|root,COG1848@2|Bacteria,2H8TE@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0005575,GO:0005576,GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_5261727_3	1267535.KB906767_gene4754	2.92e-41	156.0	COG1670@1|root,COG1670@2|Bacteria,3Y8MW@57723|Acidobacteria,2JNG8@204432|Acidobacteriia	204432|Acidobacteriia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_5261727_4	1121106.JQKB01000020_gene2002	2.415e-14	78.0	COG1670@1|root,COG1670@2|Bacteria,1RCX2@1224|Proteobacteria,2U97G@28211|Alphaproteobacteria,2JZN0@204441|Rhodospirillales	204441|Rhodospirillales	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS2_k127_5261727_1	91464.S7335_307	5.266e-159	508.0	COG1533@1|root,COG1533@2|Bacteria	2|Bacteria	L	DNA photolyase activity	splB	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	-
TLS2_k127_5261727_2	1267535.KB906767_gene218	7.813e-130	433.0	COG3964@1|root,COG3964@2|Bacteria,3Y42F@57723|Acidobacteria	57723|Acidobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5261727_0	234267.Acid_2879	1.026e-269	857.0	COG4386@1|root,COG4386@2|Bacteria,3Y76B@57723|Acidobacteria	57723|Acidobacteria	S	tail sheath protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5263218_0	981336.F944_01603	1.394e-110	361.0	COG1335@1|root,COG1335@2|Bacteria,1MWFQ@1224|Proteobacteria,1RMHF@1236|Gammaproteobacteria,3NKBR@468|Moraxellaceae	1236|Gammaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS2_k127_5263218_1	313628.LNTAR_06234	1.447e-38	161.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	2.7.7.49	ko:K00986,ko:K07497	-	-	-	-	ko00000,ko01000	-	-	-	HTH_32,rve,rve_3
TLS2_k127_5263218_2	1280941.HY2_16785	2.431e-13	74.0	COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
TLS2_k127_5272043_1	234267.Acid_3077	1.689e-212	666.0	COG0304@1|root,COG3321@1|root,COG4221@1|root,COG0304@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,3Y347@57723|Acidobacteria	57723|Acidobacteria	Q	Acyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
TLS2_k127_5272043_0	234267.Acid_3078	5.076e-258	806.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_5272043_7	886293.Sinac_5086	2.845e-66	239.0	COG0673@1|root,COG0673@2|Bacteria,2J25B@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_5272043_3	234267.Acid_5204	6.857e-120	402.0	COG1232@1|root,COG1232@2|Bacteria,3Y2X5@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS2_k127_5272043_6	234267.Acid_5202	2.699e-79	265.0	COG0407@1|root,COG0407@2|Bacteria,3Y44R@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS2_k127_5272043_4	1340493.JNIF01000003_gene2874	5.257e-100	333.0	COG0407@1|root,COG0407@2|Bacteria,3Y44R@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS2_k127_5272043_2	234267.Acid_5201	5.064e-128	419.0	COG1477@1|root,COG1477@2|Bacteria,3Y4B0@57723|Acidobacteria	57723|Acidobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
TLS2_k127_5272043_8	1267535.KB906767_gene3292	2.521e-29	121.0	COG0858@1|root,COG0858@2|Bacteria,3Y4X8@57723|Acidobacteria	57723|Acidobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
TLS2_k127_5272043_5	234267.Acid_1533	1.194e-89	306.0	COG2866@1|root,COG2866@2|Bacteria,3Y416@57723|Acidobacteria	57723|Acidobacteria	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS2_k127_5277653_1	2340.JV46_22530	2.747e-72	256.0	COG0845@1|root,COG0845@2|Bacteria,1PDUT@1224|Proteobacteria,1RQKD@1236|Gammaproteobacteria,1JBNA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_3,HlyD_D23,OEP
TLS2_k127_5277653_0	56780.SYN_00284	1.373e-146	477.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,42PQC@68525|delta/epsilon subdivisions,2WJ8K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_5279747_8	1267535.KB906767_gene656	2.375e-24	103.0	COG1032@1|root,COG1032@2|Bacteria,3Y2FN@57723|Acidobacteria,2JI6W@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_5279747_3	639030.JHVA01000001_gene899	8.237e-115	372.0	COG1032@1|root,COG1032@2|Bacteria,3Y2FN@57723|Acidobacteria,2JI6W@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_5279747_6	1121106.JQKB01000080_gene2760	8.749e-72	257.0	COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2UNXP@28211|Alphaproteobacteria,2JQXX@204441|Rhodospirillales	204441|Rhodospirillales	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_5279747_2	1340493.JNIF01000003_gene4081	2.965e-132	426.0	COG3959@1|root,COG3959@2|Bacteria,3Y4PX@57723|Acidobacteria	57723|Acidobacteria	G	1-deoxy-D-xylulose-5-phosphate synthase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS2_k127_5279747_1	234267.Acid_2452	7.624e-139	448.0	COG3958@1|root,COG3958@2|Bacteria,3Y7P5@57723|Acidobacteria	57723|Acidobacteria	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_5279747_7	234267.Acid_2451	4.219e-47	178.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K11617	ko02020,map02020	M00481,M00754	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA_3,PAS_4,PAS_8,Sensor
TLS2_k127_5279747_5	234267.Acid_2450	1.005e-102	338.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
TLS2_k127_5279747_4	1267535.KB906767_gene347	5.003e-104	347.0	COG2159@1|root,COG2159@2|Bacteria,3Y6P0@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_5279747_0	1396418.BATQ01000020_gene5035	7.336e-157	508.0	COG3119@1|root,COG3119@2|Bacteria,46ZJS@74201|Verrucomicrobia,2IVBK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_5282824_1	1267535.KB906767_gene1896	1.859e-195	612.0	COG0296@1|root,COG2382@1|root,COG0296@2|Bacteria,COG2382@2|Bacteria,3Y2ZN@57723|Acidobacteria,2JP2N@204432|Acidobacteriia	204432|Acidobacteriia	GP	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase
TLS2_k127_5282824_2	234267.Acid_7792	3.02e-15	76.0	COG1724@1|root,COG1724@2|Bacteria,3Y5Y9@57723|Acidobacteria	57723|Acidobacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
TLS2_k127_5282824_4	317936.Nos7107_2981	9.944e-06	49.0	COG2929@1|root,COG2929@2|Bacteria,1G92M@1117|Cyanobacteria,1HSNE@1161|Nostocales	1117|Cyanobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
TLS2_k127_5282824_3	497965.Cyan7822_3224	1.04e-10	68.0	2C6B2@1|root,335GA@2|Bacteria,1GRBH@1117|Cyanobacteria,3KKV9@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5282824_0	1267533.KB906738_gene2027	9.816e-224	702.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_5287499_1	234267.Acid_6655	2.419e-106	350.0	2C57D@1|root,2Z7RS@2|Bacteria,3Y3Y2@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2891)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2891
TLS2_k127_5287499_0	1005048.CFU_1201	9.58e-284	888.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2VIWI@28216|Betaproteobacteria,47391@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Penicillin amidase	penA	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS2_k127_5296951_2	94624.Bpet1409	4.526e-16	81.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2VK01@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Resolvase domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_5296951_0	502025.Hoch_0991	1.1e-69	244.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,4313Z@68525|delta/epsilon subdivisions,2WX2K@28221|Deltaproteobacteria,2Z2QP@29|Myxococcales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_5296951_3	1121004.ATVC01000022_gene1699	3.774e-13	72.0	2CGNP@1|root,32S4A@2|Bacteria,1N1J7@1224|Proteobacteria,2VUN9@28216|Betaproteobacteria,2KRN5@206351|Neisseriales	206351|Neisseriales	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5296951_1	1267535.KB906767_gene2521	4.486e-48	177.0	294EW@1|root,2ZRUR@2|Bacteria,3Y5CG@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1569)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1569
TLS2_k127_5297080_0	234267.Acid_7888	3.53e-195	616.0	COG0133@1|root,COG0133@2|Bacteria,3Y45B@57723|Acidobacteria	57723|Acidobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_5297080_1	1267535.KB906767_gene284	9.239e-47	175.0	COG0159@1|root,COG0159@2|Bacteria,3Y3X2@57723|Acidobacteria,2JI7C@204432|Acidobacteriia	204432|Acidobacteriia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
TLS2_k127_53053_3	1227500.C494_06265	1.388e-23	105.0	arCOG06405@1|root,arCOG06405@2157|Archaea,2XT62@28890|Euryarchaeota,23T26@183963|Halobacteria	183963|Halobacteria	F	HTTM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	VKG_Carbox
TLS2_k127_53053_4	234267.Acid_5063	1.668e-07	57.0	COG2318@1|root,COG2318@2|Bacteria,3Y8H7@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
TLS2_k127_53053_2	696281.Desru_1115	1.743e-55	216.0	2F459@1|root,33WWJ@2|Bacteria	2|Bacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS2_k127_53053_0	1340493.JNIF01000004_gene393	2.451e-62	223.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
TLS2_k127_53053_1	1038858.AXBA01000035_gene296	4.427e-56	203.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2TR4T@28211|Alphaproteobacteria,3EYPA@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TLS2_k127_5309819_6	234267.Acid_2178	8.252e-30	120.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,3Y5SN@57723|Acidobacteria	57723|Acidobacteria	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
TLS2_k127_5309819_2	1128421.JAGA01000002_gene1182	5.616e-77	271.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_5309819_5	234267.Acid_2539	3.221e-46	179.0	2DJMQ@1|root,32UDD@2|Bacteria,3Y57W@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5309819_3	1128427.KB904821_gene4158	1.104e-74	266.0	COG1295@1|root,COG1295@2|Bacteria,1G1HS@1117|Cyanobacteria,1H9BW@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Ribonuclease BN-like family	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_5309819_4	926560.KE387027_gene1088	7.357e-68	246.0	COG4251@1|root,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HAMP,HATPase_c,HisKA,PAS_4
TLS2_k127_5309819_0	204669.Acid345_0067	1.052e-169	546.0	COG0467@1|root,COG0467@2|Bacteria,3Y2U8@57723|Acidobacteria,2JIQ8@204432|Acidobacteriia	204432|Acidobacteriia	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
TLS2_k127_5309819_1	1267535.KB906767_gene5453	4.855e-169	541.0	COG2271@1|root,COG2271@2|Bacteria,3Y6PG@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_5343654_6	1340493.JNIF01000003_gene4147	6.544e-49	178.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_5343654_1	1267535.KB906767_gene842	2.694e-219	685.0	COG0448@1|root,COG0448@2|Bacteria,3Y35M@57723|Acidobacteria,2JIZF@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_5343654_4	234267.Acid_3915	3.891e-79	274.0	COG0363@1|root,COG0363@2|Bacteria,3Y51I@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glucosamine galactosamine-6-phosphate isomerase	-	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso
TLS2_k127_5343654_0	234267.Acid_4936	2.716e-249	790.0	COG2366@1|root,COG2366@2|Bacteria,3Y2PX@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS2_k127_5343654_2	1267535.KB906767_gene517	1.975e-147	479.0	COG1253@1|root,COG1253@2|Bacteria,3Y2KE@57723|Acidobacteria,2JHJ4@204432|Acidobacteriia	204432|Acidobacteriia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_5343654_5	1254432.SCE1572_25325	2.17e-77	268.0	COG0748@1|root,COG0748@2|Bacteria,1RFVC@1224|Proteobacteria,42UK2@68525|delta/epsilon subdivisions,2WR4V@28221|Deltaproteobacteria,2Z1V6@29|Myxococcales	28221|Deltaproteobacteria	P	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07226	-	-	-	-	ko00000	-	-	-	DUF2470,Pyrid_oxidase_2
TLS2_k127_5343654_7	543632.JOJL01000016_gene8769	2.412e-39	151.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_5343654_8	401526.TcarDRAFT_2729	0.0001057	49.0	COG3464@1|root,COG3464@2|Bacteria,1VFE7@1239|Firmicutes	1239|Firmicutes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5353545_0	622637.KE124774_gene3938	7.73e-247	793.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1MX5Z@1224|Proteobacteria,2U0IP@28211|Alphaproteobacteria,36ZD7@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_tranf_2_3,Glycos_transf_2
TLS2_k127_5371653_11	682795.AciX8_3597	2.384e-60	216.0	COG1629@1|root,COG4771@2|Bacteria,3Y3HY@57723|Acidobacteria,2JIYZ@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_5371653_9	1123277.KB893178_gene2638	4.132e-87	301.0	COG4247@1|root,COG4247@2|Bacteria,4NH2W@976|Bacteroidetes,47N7A@768503|Cytophagia	976|Bacteroidetes	I	Phytase	-	-	3.1.3.8	ko:K01083	ko00562,map00562	-	R03371	RC00078	ko00000,ko00001,ko01000	-	-	-	Phytase
TLS2_k127_5371653_5	234267.Acid_0480	3.703e-164	537.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_5371653_0	1267535.KB906767_gene1172	1.961e-250	792.0	COG1003@1|root,COG1003@2|Bacteria,3Y2UZ@57723|Acidobacteria,2JIAN@204432|Acidobacteriia	204432|Acidobacteriia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
TLS2_k127_5371653_1	234267.Acid_0482	6.699e-211	662.0	COG0403@1|root,COG0403@2|Bacteria,3Y2WZ@57723|Acidobacteria	57723|Acidobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
TLS2_k127_5371653_12	234267.Acid_0483	6.399e-55	198.0	COG0509@1|root,COG0509@2|Bacteria,3Y55C@57723|Acidobacteria	57723|Acidobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
TLS2_k127_5371653_4	234267.Acid_0484	3.467e-171	546.0	COG0404@1|root,COG0404@2|Bacteria,3Y3IU@57723|Acidobacteria	57723|Acidobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TLS2_k127_5371653_15	234267.Acid_6606	1.299e-09	71.0	2BXJ9@1|root,2ZNPM@2|Bacteria,3Y966@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5371653_10	234267.Acid_7025	1.797e-70	248.0	2F5GG@1|root,33Y23@2|Bacteria,3Y7UU@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5371653_8	1267535.KB906767_gene3352	6.907e-102	342.0	COG2199@1|root,COG3706@2|Bacteria,3Y7SF@57723|Acidobacteria,2JNA1@204432|Acidobacteriia	204432|Acidobacteriia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
TLS2_k127_5371653_7	1267535.KB906767_gene5513	2.722e-109	368.0	COG0860@1|root,COG0860@2|Bacteria,3Y3M0@57723|Acidobacteria,2JI9V@204432|Acidobacteriia	204432|Acidobacteriia	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
TLS2_k127_5371653_13	1340493.JNIF01000003_gene1728	6.588e-44	170.0	COG0741@1|root,COG0741@2|Bacteria	2|Bacteria	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124,SLT
TLS2_k127_5371653_14	234267.Acid_4588	1.222e-30	131.0	COG0746@1|root,COG0746@2|Bacteria	2|Bacteria	H	molybdenum cofactor guanylyltransferase activity	mobA	-	2.7.7.77,4.6.1.17	ko:K03637,ko:K03752,ko:K13818	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372,R11581	RC03425	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
TLS2_k127_5371653_6	234267.Acid_4589	2.448e-126	407.0	COG1127@1|root,COG1127@2|Bacteria,3Y45H@57723|Acidobacteria	57723|Acidobacteria	Q	pfam abc	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TLS2_k127_5371653_2	1123278.KB893444_gene1710	3.53e-180	576.0	COG0624@1|root,COG0624@2|Bacteria,4NEHJ@976|Bacteroidetes,47MC5@768503|Cytophagia	976|Bacteroidetes	E	Peptidase dimerisation domain	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_5371653_3	234267.Acid_6412	2.16e-178	591.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_5373470_4	1340493.JNIF01000003_gene2795	1.226e-45	171.0	COG0009@1|root,COG0009@2|Bacteria,3Y3VW@57723|Acidobacteria	57723|Acidobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
TLS2_k127_5373470_5	234267.Acid_6702	9.147e-10	65.0	2EN0M@1|root,33FNU@2|Bacteria,3Y60X@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5373470_0	234267.Acid_6703	5.061e-102	337.0	COG0176@1|root,COG0176@2|Bacteria,3Y4BN@57723|Acidobacteria	57723|Acidobacteria	G	Transaldolase/Fructose-6-phosphate aldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TLS2_k127_5373470_2	1340493.JNIF01000003_gene1489	3.983e-81	277.0	COG0179@1|root,COG0179@2|Bacteria,3Y30T@57723|Acidobacteria	57723|Acidobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
TLS2_k127_5373470_1	861299.J421_4397	1.457e-88	302.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	yflN	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_5373470_3	240016.ABIZ01000001_gene877	1.151e-73	261.0	COG0657@1|root,COG0657@2|Bacteria,46ZMC@74201|Verrucomicrobia,2IVRI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS2_k127_5373470_6	1267535.KB906767_gene3726	1.36e-09	59.0	2A08J@1|root,30NBU@2|Bacteria,3Y8SW@57723|Acidobacteria,2JNXI@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5374472_0	452637.Oter_2278	4.555e-88	303.0	COG1073@1|root,COG3250@1|root,COG1073@2|Bacteria,COG3250@2|Bacteria,46Z55@74201|Verrucomicrobia,3K7F1@414999|Opitutae	414999|Opitutae	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
TLS2_k127_5374472_1	936455.KI421499_gene7517	2.362e-46	186.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,3K3G7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Protein of unknown function (DUF229)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_5374472_2	376733.IT41_02470	1.26e-11	67.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,2TT9G@28211|Alphaproteobacteria,2PWDV@265|Paracoccus	28211|Alphaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
TLS2_k127_537879_0	344747.PM8797T_05840	2.048e-167	544.0	COG3119@1|root,COG3119@2|Bacteria,2IXR4@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.12	ko:K01135	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00076,M00077	R07823	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
TLS2_k127_537879_1	682795.AciX8_1804	1.933e-62	219.0	COG0534@1|root,COG0534@2|Bacteria,3Y6HQ@57723|Acidobacteria	57723|Acidobacteria	V	PFAM multi antimicrobial extrusion protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
TLS2_k127_5380238_12	1121104.AQXH01000004_gene61	1.318e-38	147.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
TLS2_k127_5380238_9	1232437.KL662038_gene2304	1.742e-54	202.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42NUP@68525|delta/epsilon subdivisions,2WKSD@28221|Deltaproteobacteria,2MNKG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	mscS-1	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
TLS2_k127_5380238_0	234267.Acid_0040	6.17e-207	647.0	COG1960@1|root,COG1960@2|Bacteria,3Y2FM@57723|Acidobacteria	57723|Acidobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_5380238_2	1340493.JNIF01000003_gene1755	8.503e-188	599.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_5380238_4	1340493.JNIF01000003_gene1756	1.492e-156	519.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_2,PSCyt2,PSD1
TLS2_k127_5380238_13	1267535.KB906767_gene2621	5.417e-26	117.0	2985T@1|root,2ZVBP@2|Bacteria,3Y971@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5380238_11	1267535.KB906767_gene619	5.754e-52	195.0	COG2165@1|root,COG2165@2|Bacteria,3Y4X6@57723|Acidobacteria	57723|Acidobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl
TLS2_k127_5380238_3	1340493.JNIF01000004_gene736	6.48e-169	546.0	COG1680@1|root,COG1680@2|Bacteria,3Y6TE@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_5380238_10	502025.Hoch_1576	1.114e-53	195.0	COG1595@1|root,COG1595@2|Bacteria,1RINW@1224|Proteobacteria,4385N@68525|delta/epsilon subdivisions,2X3FI@28221|Deltaproteobacteria,2YVVV@29|Myxococcales	28221|Deltaproteobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_5380238_7	234267.Acid_4915	1.276e-102	340.0	COG0584@1|root,COG0584@2|Bacteria,3Y40Q@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS2_k127_5380238_1	1340493.JNIF01000003_gene2854	4.616e-189	612.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_5380238_8	1340493.JNIF01000003_gene2855	8.29e-93	317.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,Copper-bind,Cytochrom_C,Laminin_G_3
TLS2_k127_5380238_6	1267535.KB906767_gene3520	2.415e-117	381.0	COG1136@1|root,COG1136@2|Bacteria,3Y4A6@57723|Acidobacteria,2JMVQ@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_5380238_5	234267.Acid_1656	3.847e-126	411.0	COG0845@1|root,COG0845@2|Bacteria,3Y50Z@57723|Acidobacteria	57723|Acidobacteria	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TLS2_k127_5383238_0	156889.Mmc1_2782	1.874e-100	338.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,2U24Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
TLS2_k127_5383238_1	502025.Hoch_2959	3.171e-85	289.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,4313Z@68525|delta/epsilon subdivisions,2WX2K@28221|Deltaproteobacteria,2Z2QP@29|Myxococcales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_5383238_2	696747.NIES39_Q00740	2.272e-75	258.0	COG2345@1|root,COG2345@2|Bacteria,1G44B@1117|Cyanobacteria,1HAJI@1150|Oscillatoriales	1117|Cyanobacteria	K	Transcriptional regulator	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_5383238_3	1267535.KB906767_gene5402	3.276e-11	72.0	COG4251@1|root,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_5385532_1	530564.Psta_4590	7.732e-124	405.0	COG1294@1|root,COG1294@2|Bacteria,2IY5D@203682|Planctomycetes	203682|Planctomycetes	C	COG1294 Cytochrome bd-type quinol oxidase subunit 2	-	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
TLS2_k127_5385532_0	756272.Plabr_1583	1.461e-191	610.0	COG1271@1|root,COG1271@2|Bacteria,2IXYC@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome bd-type quinol oxidase subunit 1	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
TLS2_k127_5385532_2	234267.Acid_5395	6.676e-65	226.0	COG1434@1|root,COG1434@2|Bacteria,3Y4FT@57723|Acidobacteria	57723|Acidobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
TLS2_k127_5388514_0	234267.Acid_4998	6.254e-72	250.0	COG2017@1|root,COG2017@2|Bacteria,3Y7G9@57723|Acidobacteria	57723|Acidobacteria	G	Aldose 1-epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Aldose_epim
TLS2_k127_5388514_1	234267.Acid_5763	2.929e-45	171.0	COG0247@1|root,COG0247@2|Bacteria,3Y4IR@57723|Acidobacteria	57723|Acidobacteria	C	Cysteine-rich domain	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
TLS2_k127_5389355_0	331869.BAL199_12636	1.797e-142	460.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
TLS2_k127_5404413_1	1267535.KB906767_gene4651	3.402e-75	254.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_5404413_2	240015.ACP_1525	9.999e-39	147.0	COG1695@1|root,COG1695@2|Bacteria,3Y5BK@57723|Acidobacteria,2JJRQ@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_5404413_0	234267.Acid_3778	4.942e-164	548.0	COG0577@1|root,COG0577@2|Bacteria,3Y3Z1@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_5404413_3	357808.RoseRS_3830	2.621e-34	137.0	COG0474@1|root,COG0474@2|Bacteria,2GAPR@200795|Chloroflexi,376Z7@32061|Chloroflexia	32061|Chloroflexia	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	-	-	-	ko:K16905	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_5404956_0	234267.Acid_3256	7.851e-98	328.0	COG2259@1|root,COG2259@2|Bacteria,3Y7PU@57723|Acidobacteria	57723|Acidobacteria	S	Doxx family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5404956_4	397278.JOJN01000001_gene3066	8.442e-22	98.0	COG1359@1|root,COG1359@2|Bacteria,2HPFI@201174|Actinobacteria,4DW18@85009|Propionibacteriales	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS2_k127_5404956_3	1340493.JNIF01000003_gene3311	3.193e-30	121.0	2CBEB@1|root,32STF@2|Bacteria,3Y5AC@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5404956_1	1340493.JNIF01000003_gene1947	6.494e-96	321.0	COG0657@1|root,COG0657@2|Bacteria,3Y44Z@57723|Acidobacteria	57723|Acidobacteria	I	Alpha beta hydrolase fold-3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS2_k127_5404956_2	1340493.JNIF01000003_gene2778	6.425e-35	138.0	COG1295@1|root,COG1295@2|Bacteria,3Y4P8@57723|Acidobacteria	57723|Acidobacteria	S	PFAM ribonuclease	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_5416895_3	234267.Acid_3457	4.817e-49	180.0	COG1173@1|root,COG1173@2|Bacteria,3Y45P@57723|Acidobacteria	57723|Acidobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_5416895_1	234267.Acid_3456	8.658e-162	527.0	COG0747@1|root,COG0747@2|Bacteria,3Y44K@57723|Acidobacteria	57723|Acidobacteria	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_5416895_2	234267.Acid_3455	2.261e-54	197.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_5416895_0	234267.Acid_3133	1.669e-175	577.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,3Y7SH@57723|Acidobacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,PD40,TPR_10,TPR_12,TPR_8
TLS2_k127_5417341_7	94624.Bpet2880	4.382e-35	142.0	COG0583@1|root,COG0583@2|Bacteria,1NUAB@1224|Proteobacteria,2VPVE@28216|Betaproteobacteria,3T8MG@506|Alcaligenaceae	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	ko:K11921	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
TLS2_k127_5417341_3	1346330.M472_21480	1.383e-82	288.0	COG4948@1|root,COG4948@2|Bacteria,4NIIJ@976|Bacteroidetes,1IUSW@117747|Sphingobacteriia	976|Bacteroidetes	M	Mandelate racemase muconate lactonizing enzyme, N-terminal domain	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_5417341_4	886293.Sinac_3318	1.072e-67	246.0	COG2271@1|root,COG2807@1|root,COG2271@2|Bacteria,COG2807@2|Bacteria,2IZV2@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
TLS2_k127_5417341_9	1324957.K933_00492	0.0001751	53.0	COG2159@1|root,arCOG01931@2157|Archaea,2XTTE@28890|Euryarchaeota,23UQH@183963|Halobacteria	183963|Halobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	ko:K07046	ko00051,ko01120,map00051,map01120	-	R10689	RC00537	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
TLS2_k127_5417341_5	1123274.KB899420_gene4011	7.225e-52	196.0	COG0329@1|root,COG0329@2|Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_5417341_8	365046.Rta_24750	1.097e-19	100.0	COG0673@1|root,COG0673@2|Bacteria,1MXUP@1224|Proteobacteria,2VIRJ@28216|Betaproteobacteria,4AAC0@80864|Comamonadaceae	28216|Betaproteobacteria	S	Oxidoreductase	ligC	-	1.1.1.312	ko:K10219	ko00350,ko00362,ko00627,ko01120,ko01220,map00350,map00362,map00627,map01120,map01220	M00533	R04278,R04279,R04418,R04419	RC00251,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_zinc_N,GFO_IDH_MocA
TLS2_k127_5417341_2	383372.Rcas_3343	7.371e-83	286.0	COG2084@1|root,COG2084@2|Bacteria,2G6B3@200795|Chloroflexi,376B1@32061|Chloroflexia	32061|Chloroflexia	I	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_5417341_6	240016.ABIZ01000001_gene1481	1.397e-37	165.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_7,DLH
TLS2_k127_5417341_0	1267535.KB906767_gene942	8.889e-183	611.0	COG1629@1|root,COG4771@2|Bacteria,3Y2ZK@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_5417341_1	471854.Dfer_5257	1.89e-151	489.0	COG0001@1|root,COG0001@2|Bacteria,4NK1U@976|Bacteroidetes,47UFQ@768503|Cytophagia	976|Bacteroidetes	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_544386_3	1218084.BBJK01000017_gene1930	6.273e-29	116.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2VIWI@28216|Betaproteobacteria,1K590@119060|Burkholderiaceae	28216|Betaproteobacteria	S	penicillin amidase	penA	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS2_k127_544386_2	234267.Acid_7823	1.161e-55	208.0	COG2017@1|root,COG2017@2|Bacteria,3Y4YM@57723|Acidobacteria	57723|Acidobacteria	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_544386_0	448385.sce7264	9.285e-103	366.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2YTXT@29|Myxococcales	28221|Deltaproteobacteria	J	Ribonuclease E/G family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
TLS2_k127_544386_1	1340493.JNIF01000003_gene3683	2.034e-79	268.0	COG0772@1|root,COG0772@2|Bacteria,3Y3DZ@57723|Acidobacteria	57723|Acidobacteria	M	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
TLS2_k127_5444327_3	931627.MycrhDRAFT_5262	2.623e-07	60.0	COG3386@1|root,COG3386@2|Bacteria,2GNV1@201174|Actinobacteria,236DC@1762|Mycobacteriaceae	201174|Actinobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	SGL
TLS2_k127_5444327_1	1340493.JNIF01000003_gene1797	2.109e-142	469.0	2CD2X@1|root,2Z7RW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5444327_2	234267.Acid_1046	7.051e-139	445.0	COG3836@1|root,COG3836@2|Bacteria	2|Bacteria	G	2-keto-3-deoxy-L-rhamnonate aldolase activity	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_5444327_0	1340493.JNIF01000003_gene3114	2.083e-190	603.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_5444329_1	555779.Dthio_PD0435	5.238e-32	134.0	COG5421@1|root,COG5421@2|Bacteria,1R7NE@1224|Proteobacteria,42M25@68525|delta/epsilon subdivisions,2WKHV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TLS2_k127_5444329_0	555779.Dthio_PD0435	1.867e-53	199.0	COG5421@1|root,COG5421@2|Bacteria,1R7NE@1224|Proteobacteria,42M25@68525|delta/epsilon subdivisions,2WKHV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TLS2_k127_5450372_0	1267535.KB906767_gene2507	3.61e-214	676.0	COG0272@1|root,COG0272@2|Bacteria,3Y2UR@57723|Acidobacteria,2JHN1@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
TLS2_k127_5456167_11	234267.Acid_4110	6.374e-34	133.0	2F354@1|root,33VZU@2|Bacteria,3Y7X0@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5456167_4	1267535.KB906767_gene2466	4.192e-147	471.0	2BKJ2@1|root,32F0A@2|Bacteria,3Y70Q@57723|Acidobacteria	57723|Acidobacteria	S	P22 coat protein - gene protein 5	-	-	-	-	-	-	-	-	-	-	-	-	P22_CoatProtein
TLS2_k127_5456167_15	234267.Acid_4112	1.637e-13	75.0	2CB8U@1|root,2ZFXN@2|Bacteria,3Y96M@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5456167_8	234267.Acid_4113	4.507e-41	162.0	2CB8V@1|root,342T5@2|Bacteria,3Y892@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5456167_10	234267.Acid_4114	2.078e-34	137.0	2CDPF@1|root,349CP@2|Bacteria,3Y8RA@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5456167_6	234267.Acid_4115	1.468e-121	404.0	2EVZF@1|root,33PCY@2|Bacteria,3Y6QQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5456167_12	234267.Acid_4116	1.047e-30	124.0	299A7@1|root,2ZWDD@2|Bacteria,3Y8TK@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5456167_14	234267.Acid_4118	1.544e-14	83.0	297ZP@1|root,2ZV5T@2|Bacteria,3Y972@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5456167_13	234267.Acid_4119	1.132e-25	110.0	28VY7@1|root,2ZHZF@2|Bacteria,3Y97D@57723|Acidobacteria	57723|Acidobacteria	S	Conserved hypothetical protein 2217 (DUF2460)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2460
TLS2_k127_5456167_9	234267.Acid_4120	6.475e-41	161.0	28VY7@1|root,3470P@2|Bacteria,3Y8J4@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5456167_0	234267.Acid_4121	0.0	1262.0	COG4733@1|root,COG4733@2|Bacteria,3Y67A@57723|Acidobacteria	57723|Acidobacteria	S	Putative phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage-tail_3
TLS2_k127_5456167_7	1340493.JNIF01000003_gene3698	2.01e-107	363.0	COG1134@1|root,COG1134@2|Bacteria	2|Bacteria	GM	teichoic acid transport	wzt	-	3.6.3.38	ko:K09689,ko:K09691	ko02010,map02010	M00249,M00250	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.101,3.A.1.103	-	-	ABC_tran,Wzt_C
TLS2_k127_5456167_2	234267.Acid_0372	2.708e-174	559.0	COG3104@1|root,COG3104@2|Bacteria,3Y6W5@57723|Acidobacteria	57723|Acidobacteria	E	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
TLS2_k127_5456167_3	1267535.KB906767_gene2246	3.252e-163	522.0	COG0006@1|root,COG0006@2|Bacteria,3Y3I4@57723|Acidobacteria,2JIWQ@204432|Acidobacteriia	204432|Acidobacteriia	E	Metallopeptidase family M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS2_k127_5456167_1	1267535.KB906767_gene1538	6.804e-184	588.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	DUF1863,FG-GAP,PQQ_2,VCBS,fn3
TLS2_k127_5456167_5	1192034.CAP_6431	6.84e-135	434.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,42M9F@68525|delta/epsilon subdivisions,2WJNB@28221|Deltaproteobacteria,2YU00@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_5456329_2	1340493.JNIF01000003_gene1526	2e-181	573.0	COG0653@1|root,COG0653@2|Bacteria,3Y34P@57723|Acidobacteria	57723|Acidobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TLS2_k127_5456329_4	1122176.KB903543_gene569	1.402e-83	284.0	COG0450@1|root,COG0450@2|Bacteria,4NEZZ@976|Bacteroidetes,1IPQ0@117747|Sphingobacteriia	976|Bacteroidetes	O	AhpC TSA family	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
TLS2_k127_5456329_0	1340493.JNIF01000003_gene2760	0.0	1283.0	COG2067@1|root,COG2067@2|Bacteria,3Y41G@57723|Acidobacteria	57723|Acidobacteria	I	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_5456329_1	639030.JHVA01000001_gene2486	1.612e-205	648.0	COG4946@1|root,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5456329_3	1340493.JNIF01000003_gene4600	2.238e-178	572.0	COG1629@1|root,COG4771@2|Bacteria,3Y66U@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_5459785_0	234267.Acid_5927	1.892e-114	390.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y6TZ@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
TLS2_k127_5459785_3	479434.Sthe_0272	3.754e-52	197.0	COG0491@1|root,COG0491@2|Bacteria,2GBAB@200795|Chloroflexi,27YH3@189775|Thermomicrobia	189775|Thermomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_5459785_2	234267.Acid_1459	3.242e-81	280.0	COG0702@1|root,COG0702@2|Bacteria,3Y755@57723|Acidobacteria	57723|Acidobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
TLS2_k127_5459785_1	234267.Acid_5927	4.831e-102	355.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y6TZ@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
TLS2_k127_5459785_4	234267.Acid_2134	1.032e-05	50.0	2AC2T@1|root,311KW@2|Bacteria,3Y4QM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5461109_1	1340493.JNIF01000004_gene349	2.615e-128	413.0	COG0056@1|root,COG0056@2|Bacteria,3Y2R6@57723|Acidobacteria	57723|Acidobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
TLS2_k127_5461109_2	1340493.JNIF01000004_gene350	7.802e-113	370.0	COG0224@1|root,COG0224@2|Bacteria,3Y3MN@57723|Acidobacteria	57723|Acidobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
TLS2_k127_5461109_0	502025.Hoch_6062	2.698e-213	672.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,42KZA@68525|delta/epsilon subdivisions,2WJ1V@28221|Deltaproteobacteria,2YU1A@29|Myxococcales	28221|Deltaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS2_k127_5461109_3	234267.Acid_0466	1.964e-29	122.0	COG0355@1|root,COG0355@2|Bacteria,3Y5VV@57723|Acidobacteria	57723|Acidobacteria	C	ATP synthase, Delta/Epsilon chain, beta-sandwich domain	-	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
TLS2_k127_5461109_4	246197.MXAN_3892	6.05e-17	80.0	COG0110@1|root,COG0110@2|Bacteria,1RA2T@1224|Proteobacteria,42Z2R@68525|delta/epsilon subdivisions,2WUGF@28221|Deltaproteobacteria,2Z37Y@29|Myxococcales	28221|Deltaproteobacteria	S	Maltose acetyltransferase	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Mac
TLS2_k127_5462304_2	452637.Oter_4108	1.039e-137	444.0	COG0427@1|root,COG0427@2|Bacteria,46TQC@74201|Verrucomicrobia,3K7AC@414999|Opitutae	414999|Opitutae	C	acetyl-CoA hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
TLS2_k127_5462304_4	502025.Hoch_3450	2.178e-107	366.0	COG0471@1|root,COG0471@2|Bacteria,1R6QF@1224|Proteobacteria,42MU1@68525|delta/epsilon subdivisions,2X5M3@28221|Deltaproteobacteria,2YV9R@29|Myxococcales	28221|Deltaproteobacteria	P	Citrate transporter	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	CitMHS
TLS2_k127_5462304_5	1267535.KB906767_gene4977	9.322e-100	332.0	COG0648@1|root,COG0648@2|Bacteria,3Y35C@57723|Acidobacteria,2JI8X@204432|Acidobacteriia	204432|Acidobacteriia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
TLS2_k127_5462304_1	234267.Acid_0384	5.78e-191	612.0	COG0608@1|root,COG0608@2|Bacteria,3Y3HI@57723|Acidobacteria	57723|Acidobacteria	L	single-stranded-DNA-specific exonuclease RecJ	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TLS2_k127_5462304_3	240015.ACP_2892	2.38e-120	395.0	COG0031@1|root,COG0031@2|Bacteria,3Y39M@57723|Acidobacteria,2JIQR@204432|Acidobacteriia	204432|Acidobacteriia	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_5462304_8	237368.SCABRO_03617	2.657e-20	95.0	COG1310@1|root,COG1310@2|Bacteria,2J1CP@203682|Planctomycetes	203682|Planctomycetes	S	JAB/MPN domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
TLS2_k127_5462304_6	234267.Acid_0756	5.281e-36	141.0	COG1977@1|root,COG1977@2|Bacteria,3Y546@57723|Acidobacteria	57723|Acidobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS2_k127_5462304_0	234267.Acid_0755	1.164e-196	619.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,3Y3IF@57723|Acidobacteria	57723|Acidobacteria	HP	PFAM UBA THIF-type NAD FAD binding	-	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
TLS2_k127_5463909_0	234267.Acid_7573	2.084e-158	520.0	COG1629@1|root,COG4771@2|Bacteria,3Y6Q2@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_5463909_1	1340493.JNIF01000003_gene3118	1.735e-09	64.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Dioxygenase_C,Plug,TonB_dep_Rec
TLS2_k127_5475387_4	1340493.JNIF01000003_gene4475	1.647e-34	138.0	COG2318@1|root,COG2318@2|Bacteria,3Y8H7@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
TLS2_k127_5475387_2	1267535.KB906767_gene3339	3.237e-101	355.0	COG3279@1|root,COG3279@2|Bacteria,3Y3HR@57723|Acidobacteria,2JIXA@204432|Acidobacteriia	204432|Acidobacteriia	T	Two component transcriptional regulator, LytTR family	-	-	-	ko:K02477,ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
TLS2_k127_5475387_0	1267535.KB906767_gene3340	1.084e-232	726.0	COG1260@1|root,COG1260@2|Bacteria,3Y325@57723|Acidobacteria,2JIPN@204432|Acidobacteriia	204432|Acidobacteriia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
TLS2_k127_5475387_1	1340493.JNIF01000003_gene3308	1.593e-136	441.0	COG0451@1|root,COG0451@2|Bacteria,3Y5IZ@57723|Acidobacteria	57723|Acidobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_5475387_3	661478.OP10G_4632	7.52e-100	337.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
TLS2_k127_5484210_1	234267.Acid_1054	4.768e-106	352.0	COG1397@1|root,COG1397@2|Bacteria,3Y94D@57723|Acidobacteria	57723|Acidobacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
TLS2_k127_5484210_0	1121085.AUCI01000013_gene2625	7.205e-188	602.0	COG3119@1|root,COG3119@2|Bacteria,1V6NF@1239|Firmicutes,4ICAY@91061|Bacilli,1ZF1G@1386|Bacillus	91061|Bacilli	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_5484210_2	1121904.ARBP01000049_gene4415	1.575e-62	220.0	COG3250@1|root,COG3250@2|Bacteria,4NFPC@976|Bacteroidetes,47K4T@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TLS2_k127_5485063_0	395961.Cyan7425_2624	1.228e-105	350.0	COG0491@1|root,COG1141@1|root,COG0491@2|Bacteria,COG1141@2|Bacteria,1G3D1@1117|Cyanobacteria,3KHIR@43988|Cyanothece	1117|Cyanobacteria	C	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13
TLS2_k127_5486239_5	379066.GAU_2956	2.791e-51	184.0	COG0662@1|root,COG0662@2|Bacteria,1ZVA1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_5486239_6	1265503.KB905164_gene1796	1.545e-42	162.0	COG1725@1|root,COG1725@2|Bacteria	2|Bacteria	K	Transcriptional regulator	ytrA	-	-	ko:K07978	-	-	-	-	ko00000,ko03000	-	-	-	GntR
TLS2_k127_5486239_3	253839.SSNG_00536	2.904e-73	252.0	COG0662@1|root,COG0662@2|Bacteria,2IMPE@201174|Actinobacteria	201174|Actinobacteria	G	COG0662 Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_5486239_1	1033743.CAES01000080_gene3874	9.822e-87	289.0	28H95@1|root,2Z7KY@2|Bacteria,1TQTR@1239|Firmicutes,4HB82@91061|Bacilli,26UCG@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF4256)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4256
TLS2_k127_5486239_4	1357279.N018_11255	7.306e-52	198.0	COG0259@1|root,COG0259@2|Bacteria,1NUI4@1224|Proteobacteria,1SNFN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Pfam:Pyridox_oxidase	-	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
TLS2_k127_5486239_2	365046.Rta_09790	7.017e-76	256.0	COG0251@1|root,COG0251@2|Bacteria,1RCX5@1224|Proteobacteria,2VRFR@28216|Betaproteobacteria,4AE10@80864|Comamonadaceae	28216|Betaproteobacteria	J	Endoribonuclease L-PSP	yjgH	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS2_k127_5486239_0	305700.B447_20870	3.939e-182	576.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VIK6@28216|Betaproteobacteria,2KXKI@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the radical SAM superfamily. PqqE family	-	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM,SPASM
TLS2_k127_5493028_1	234267.Acid_0746	2.202e-152	520.0	COG2911@1|root,COG2911@2|Bacteria,3Y3A6@57723|Acidobacteria	57723|Acidobacteria	M	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
TLS2_k127_5493028_2	1340493.JNIF01000003_gene3621	1.073e-29	130.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	nifM	-	2.3.1.39,5.2.1.8	ko:K00645,ko:K01802,ko:K02597,ko:K03769,ko:K03770,ko:K03771	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
TLS2_k127_5493028_0	1267535.KB906767_gene3597	3.062e-226	719.0	COG4775@1|root,COG4775@2|Bacteria,3Y2RF@57723|Acidobacteria,2JHK5@204432|Acidobacteriia	204432|Acidobacteriia	M	surface antigen variable number	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
TLS2_k127_5499359_0	94624.Bpet1409	8.761e-290	905.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2VK01@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Resolvase domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_5499359_2	234267.Acid_1624	6.396e-54	191.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
TLS2_k127_5499359_1	234267.Acid_2459	6.44e-106	354.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
TLS2_k127_5503818_0	1340493.JNIF01000003_gene2160	0.0	1339.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_5503818_1	1340493.JNIF01000004_gene359	1.57e-163	529.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	Z012_03425	-	3.1.6.14	ko:K01137,ko:K01138	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078,M00079	R07808,R07819	-	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4976,Sulfatase
TLS2_k127_5503818_2	234267.Acid_4010	1.934e-30	124.0	COG3534@1|root,COG3534@2|Bacteria	2|Bacteria	G	alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
TLS2_k127_5516964_0	1340493.JNIF01000003_gene2320	2.11e-127	429.0	COG1629@1|root,COG4771@2|Bacteria	1340493.JNIF01000003_gene2320|-	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5516964_1	1267535.KB906767_gene1537	3.827e-112	375.0	COG1414@1|root,COG1879@1|root,COG1414@2|Bacteria,COG1879@2|Bacteria,3Y3RJ@57723|Acidobacteria	57723|Acidobacteria	K	IclR helix-turn-helix domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	HTH_IclR,Peripla_BP_4
TLS2_k127_5516964_2	1267535.KB906767_gene765	1.128e-61	216.0	COG2960@1|root,COG2960@2|Bacteria,3Y7EA@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
TLS2_k127_553429_2	1340493.JNIF01000003_gene4574	7.967e-234	730.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_553429_1	1340493.JNIF01000003_gene4575	0.0	1024.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Laminin_G_3,PSCyt1,PSCyt2,PSD1
TLS2_k127_553429_0	1340493.JNIF01000003_gene3565	0.0	1033.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_5538542_0	314230.DSM3645_20202	2.689e-136	449.0	COG1159@1|root,COG1159@2|Bacteria,2J52F@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF697)	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	DUF697,MMR_HSR1
TLS2_k127_5538542_1	530564.Psta_1396	5.041e-107	360.0	COG0486@1|root,COG3597@1|root,COG0486@2|Bacteria,COG3597@2|Bacteria,2IYZR@203682|Planctomycetes	203682|Planctomycetes	S	Small GTP-binding protein domain protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	DUF697,MMR_HSR1
TLS2_k127_5539183_4	204669.Acid345_3976	1.759e-10	63.0	COG0477@1|root,COG2814@2|Bacteria,3Y47I@57723|Acidobacteria,2JJ64@204432|Acidobacteriia	204432|Acidobacteriia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_5539183_2	1340493.JNIF01000003_gene4734	1.028e-50	183.0	COG0346@1|root,COG0346@2|Bacteria,3Y8F5@57723|Acidobacteria	57723|Acidobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_5539183_3	234267.Acid_7761	8.553e-35	140.0	2FHZ5@1|root,349S3@2|Bacteria,3Y8GI@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5539183_0	234267.Acid_6357	1.672e-81	293.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K21025	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	EAL,GAF_2,GGDEF,HATPase_c,HTH_17,HTH_18,HisKA,PAS,PAS_4,PAS_8,PAS_9,Reg_prop,Response_reg,Y_Y_Y
TLS2_k127_5539183_1	234267.Acid_6358	1.091e-54	204.0	COG0637@1|root,COG0637@2|Bacteria,3Y7V3@57723|Acidobacteria	57723|Acidobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS2_k127_5539183_5	1041139.KB902578_gene5176	2.021e-05	52.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2TV4H@28211|Alphaproteobacteria,4BMHT@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	macA	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_3,HlyD_D23
TLS2_k127_5541005_1	234267.Acid_0607	1.964e-33	130.0	COG3824@1|root,COG3824@2|Bacteria,3Y8W9@57723|Acidobacteria	57723|Acidobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
TLS2_k127_5541005_2	234267.Acid_6366	4.265e-24	112.0	2FHZB@1|root,349S8@2|Bacteria,3Y8KS@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5541005_0	1340493.JNIF01000003_gene2857	1.154e-59	215.0	COG4254@1|root,COG4254@2|Bacteria,3Y90P@57723|Acidobacteria	57723|Acidobacteria	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
TLS2_k127_5542296_1	204669.Acid345_3005	1.716e-17	90.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,3Y5KB@57723|Acidobacteria,2JHVK@204432|Acidobacteriia	204432|Acidobacteriia	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
TLS2_k127_5542296_0	204669.Acid345_3133	2.943e-23	104.0	COG0810@1|root,COG0810@2|Bacteria,3Y4BU@57723|Acidobacteria,2JJ3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
TLS2_k127_5542296_2	1038860.AXAP01000003_gene8380	5.543e-06	51.0	COG0028@1|root,COG0028@2|Bacteria,1MWKP@1224|Proteobacteria,2TQK6@28211|Alphaproteobacteria,3JS18@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	1.2.3.3,1.2.5.1	ko:K00156,ko:K00158	ko00620,ko01100,map00620,map01100	-	R00207,R03145	RC00860,RC02745	ko00000,ko00001,ko01000	-	-	-	Rieske,TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_5546766_0	234267.Acid_0196	1.079e-137	455.0	COG1629@1|root,COG4771@2|Bacteria,3Y3Z6@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_5553991_0	1340493.JNIF01000003_gene1533	1.452e-157	504.0	COG2204@1|root,COG2204@2|Bacteria,3Y3HZ@57723|Acidobacteria	2|Bacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_5553991_2	1340493.JNIF01000003_gene1532	1.54e-137	452.0	COG4191@1|root,COG4191@2|Bacteria,3Y5DB@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_5553991_1	926550.CLDAP_07050	3.204e-149	484.0	COG2239@1|root,COG2239@2|Bacteria,2G6H7@200795|Chloroflexi	200795|Chloroflexi	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
TLS2_k127_5553991_4	234267.Acid_6456	2.344e-22	101.0	COG1993@1|root,COG1993@2|Bacteria	2|Bacteria	T	acr, cog1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
TLS2_k127_5553991_3	1340493.JNIF01000003_gene1529	8.389e-61	212.0	COG3696@1|root,COG3696@2|Bacteria,3Y2U0@57723|Acidobacteria	57723|Acidobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
TLS2_k127_5563113_2	1296416.JACB01000003_gene1012	7.374e-08	62.0	COG3591@1|root,COG3591@2|Bacteria,4NPN5@976|Bacteroidetes,1I73X@117743|Flavobacteriia,2YHYE@290174|Aquimarina	976|Bacteroidetes	E	Trypsin-like serine protease	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin
TLS2_k127_5563113_1	105559.Nwat_0323	2.255e-99	337.0	COG0156@1|root,COG0156@2|Bacteria,1RK31@1224|Proteobacteria	1224|Proteobacteria	H	8-amino-7-oxononanoate synthase activity	-	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_5563113_0	1278073.MYSTI_01851	4.972e-161	517.0	28HPE@1|root,2Z7XE@2|Bacteria,1PV34@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5567822_0	1267535.KB906767_gene4759	0.0	1188.0	COG1629@1|root,COG1629@2|Bacteria,3Y2N1@57723|Acidobacteria,2JIIP@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_5567822_5	1267535.KB906767_gene1426	7.274e-73	254.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
TLS2_k127_5567822_8	1340493.JNIF01000003_gene2666	6.125e-37	147.0	COG3222@1|root,COG3222@2|Bacteria,3Y5T4@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
TLS2_k127_5567822_1	1267535.KB906767_gene3810	2.092e-225	711.0	COG0457@1|root,COG0457@2|Bacteria	1267535.KB906767_gene3810|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5567822_4	335543.Sfum_0447	4.482e-77	278.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS2_k127_5567822_6	756272.Plabr_3616	7.687e-71	252.0	COG0845@1|root,COG0845@2|Bacteria,2IYUX@203682|Planctomycetes	203682|Planctomycetes	M	PFAM secretion protein HlyD	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TLS2_k127_5567822_3	530564.Psta_1006	4.091e-88	298.0	COG1136@1|root,COG1136@2|Bacteria,2IYS3@203682|Planctomycetes	203682|Planctomycetes	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_5567822_2	530564.Psta_1007	2.997e-125	412.0	COG0577@1|root,COG0577@2|Bacteria,2IWXH@203682|Planctomycetes	203682|Planctomycetes	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_5567822_9	588932.JHOF01000018_gene867	5.997e-34	139.0	COG1309@1|root,COG1309@2|Bacteria,1N6R3@1224|Proteobacteria,2U76N@28211|Alphaproteobacteria,2KGJ2@204458|Caulobacterales	204458|Caulobacterales	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TLS2_k127_5567822_7	1340493.JNIF01000004_gene386	2.814e-38	144.0	COG0179@1|root,COG0179@2|Bacteria,3Y30T@57723|Acidobacteria	57723|Acidobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
TLS2_k127_5575554_3	1267535.KB906767_gene3822	1.233e-73	274.0	COG0457@1|root,COG0457@2|Bacteria,3Y4S2@57723|Acidobacteria	57723|Acidobacteria	NU	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_8
TLS2_k127_5575554_0	1267535.KB906767_gene3823	2.593e-295	947.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Dioxygenase_C,TonB_dep_Rec
TLS2_k127_5575554_1	595460.RRSWK_00625	1.077e-161	524.0	COG3119@1|root,COG3119@2|Bacteria,2J1X7@203682|Planctomycetes	203682|Planctomycetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_5575554_6	240015.ACP_0597	3.298e-30	126.0	COG5573@1|root,COG5573@2|Bacteria,3Y5UY@57723|Acidobacteria,2JK50@204432|Acidobacteriia	204432|Acidobacteriia	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_5575554_2	234267.Acid_0509	5.308e-80	273.0	COG0811@1|root,COG0811@2|Bacteria,3Y2T8@57723|Acidobacteria	57723|Acidobacteria	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
TLS2_k127_5575554_5	234267.Acid_0510	1.519e-44	166.0	COG0848@1|root,COG0848@2|Bacteria,3Y4QV@57723|Acidobacteria	57723|Acidobacteria	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS2_k127_5575554_4	1340493.JNIF01000003_gene3053	2.518e-49	185.0	COG0810@1|root,COG0810@2|Bacteria,3Y4WH@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2,TonB_C
TLS2_k127_5575554_7	234267.Acid_0512	1.62e-11	69.0	COG0823@1|root,COG0823@2|Bacteria,3Y2RC@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
TLS2_k127_5586043_0	234267.Acid_0463	1.673e-145	465.0	COG0056@1|root,COG0056@2|Bacteria,3Y2R6@57723|Acidobacteria	57723|Acidobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
TLS2_k127_5586043_1	234267.Acid_0462	9.42e-43	162.0	COG0712@1|root,COG0712@2|Bacteria,3Y4Z4@57723|Acidobacteria	57723|Acidobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
TLS2_k127_5586043_2	234267.Acid_0461	4.097e-23	109.0	COG0711@1|root,COG0711@2|Bacteria,3Y4UJ@57723|Acidobacteria	57723|Acidobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
TLS2_k127_5586043_3	1340493.JNIF01000004_gene346	3.181e-21	99.0	COG0711@1|root,COG0711@2|Bacteria,3Y4WK@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the ATPase B chain family	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
TLS2_k127_5596922_5	1267535.KB906767_gene5328	2.487e-73	257.0	COG0279@1|root,COG0279@2|Bacteria,3Y7D7@57723|Acidobacteria	57723|Acidobacteria	G	SIS domain	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
TLS2_k127_5596922_2	234267.Acid_5174	8.38e-120	396.0	COG1940@1|root,COG1940@2|Bacteria,3Y62I@57723|Acidobacteria	57723|Acidobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_5596922_4	234267.Acid_3554	1.823e-106	355.0	COG2870@1|root,COG2870@2|Bacteria,3Y680@57723|Acidobacteria	57723|Acidobacteria	M	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS2_k127_5596922_1	234267.Acid_3555	1.188e-157	505.0	COG1915@1|root,COG1915@2|Bacteria,3Y7FB@57723|Acidobacteria	57723|Acidobacteria	S	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5596922_3	1340493.JNIF01000003_gene4381	2.605e-110	362.0	COG0546@1|root,COG0546@2|Bacteria,3Y621@57723|Acidobacteria	57723|Acidobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase
TLS2_k127_5596922_6	1123242.JH636435_gene1344	3.473e-56	207.0	COG2423@1|root,COG2423@2|Bacteria,2IXT1@203682|Planctomycetes	203682|Planctomycetes	E	ornithine cyclodeaminase mu-crystallin	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
TLS2_k127_5596922_0	1340493.JNIF01000004_gene270	0.0	1327.0	COG0841@1|root,COG0841@2|Bacteria,3Y6DS@57723|Acidobacteria	57723|Acidobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TLS2_k127_5600113_5	234267.Acid_5065	1.582e-48	185.0	COG1674@1|root,COG1674@2|Bacteria,3Y3CJ@57723|Acidobacteria	57723|Acidobacteria	D	PFAM cell divisionFtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TLS2_k127_5600113_2	1267535.KB906767_gene1054	5.011e-89	301.0	COG1968@1|root,COG1968@2|Bacteria,3Y588@57723|Acidobacteria	57723|Acidobacteria	V	Bacitracin resistance protein BacA	-	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
TLS2_k127_5600113_0	1267535.KB906767_gene1055	1.329e-170	548.0	COG0469@1|root,COG0469@2|Bacteria,3Y36V@57723|Acidobacteria,2JHY5@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
TLS2_k127_5600113_3	234267.Acid_4707	8.954e-89	302.0	COG0697@1|root,COG0697@2|Bacteria,3Y570@57723|Acidobacteria	57723|Acidobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_5600113_1	234267.Acid_4598	3.282e-100	334.0	COG0253@1|root,COG0253@2|Bacteria,3Y4EC@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
TLS2_k127_5600113_4	234267.Acid_4600	8.511e-55	200.0	COG1807@1|root,COG1807@2|Bacteria,3Y3BJ@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_5600517_0	1340493.JNIF01000003_gene2575	0.0	1804.0	COG1629@1|root,COG1629@2|Bacteria,3Y3KT@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_5600517_1	234267.Acid_1901	6.645e-200	629.0	COG0174@1|root,COG0174@2|Bacteria,3Y2P8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Glutamine synthetase, catalytic	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS2_k127_5600517_2	118166.JH976537_gene3358	3.144e-12	78.0	COG2815@1|root,COG2815@2|Bacteria,1GAQE@1117|Cyanobacteria	1117|Cyanobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
TLS2_k127_5608127_1	641524.ADICYQ_0168	1.27e-146	479.0	COG5476@1|root,COG5476@2|Bacteria,4NKYT@976|Bacteroidetes,47XQY@768503|Cytophagia	976|Bacteroidetes	S	MlrC C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
TLS2_k127_5608127_0	880070.Cycma_4442	1.485e-189	599.0	28KEJ@1|root,2Z9QB@2|Bacteria,4P1U9@976|Bacteroidetes,47TF2@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5608127_2	1340493.JNIF01000003_gene4759	9.552e-36	138.0	COG2355@1|root,COG2355@2|Bacteria,3Y3RS@57723|Acidobacteria	57723|Acidobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
TLS2_k127_5616178_5	1178825.ALIH01000004_gene2796	2.12e-32	131.0	COG2271@1|root,COG2271@2|Bacteria,4NGCR@976|Bacteroidetes,1HWZ4@117743|Flavobacteriia	976|Bacteroidetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_5616178_3	1121957.ATVL01000008_gene4538	7.044e-48	182.0	COG2067@1|root,COG2067@2|Bacteria,4NJB3@976|Bacteroidetes,47JGU@768503|Cytophagia	976|Bacteroidetes	I	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
TLS2_k127_5616178_2	234267.Acid_6451	1.587e-58	213.0	COG0563@1|root,COG0563@2|Bacteria,3Y421@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	-	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
TLS2_k127_5616178_0	1382359.JIAL01000001_gene1072	5.85e-226	716.0	COG0659@1|root,COG0659@2|Bacteria,3Y3QP@57723|Acidobacteria,2JJPK@204432|Acidobacteriia	204432|Acidobacteriia	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
TLS2_k127_5616178_4	1382359.JIAL01000001_gene1071	9.625e-41	153.0	COG0640@1|root,COG0640@2|Bacteria,3Y5UV@57723|Acidobacteria,2JNP2@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_5616178_6	234267.Acid_4991	1.212e-22	100.0	2CBGA@1|root,32RQS@2|Bacteria,3Y586@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5616178_1	1340493.JNIF01000003_gene2434	9.439e-63	218.0	COG3696@1|root,COG3696@2|Bacteria,3Y6TG@57723|Acidobacteria	57723|Acidobacteria	P	AcrB/AcrD/AcrF family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
TLS2_k127_5620833_1	1123242.JH636436_gene266	1.151e-10	65.0	COG5492@1|root,COG5492@2|Bacteria,2IX44@203682|Planctomycetes	203682|Planctomycetes	N	PFAM Bacterial Ig-like domain (group 2)	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,PSCyt2,PSD1
TLS2_k127_5620833_0	1303518.CCALI_02509	2.42e-100	345.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_5621378_0	497964.CfE428DRAFT_0179	1.673e-121	406.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TLS2_k127_5660605_3	234267.Acid_6221	4.137e-22	98.0	COG0793@1|root,COG0793@2|Bacteria,3Y3KP@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
TLS2_k127_5660605_1	1267535.KB906767_gene4277	3.294e-67	235.0	COG0789@1|root,COG0789@2|Bacteria,3Y5EZ@57723|Acidobacteria,2JN9T@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_5660605_0	1340493.JNIF01000003_gene3950	3.596e-181	578.0	COG0471@1|root,COG0471@2|Bacteria,3Y6TC@57723|Acidobacteria	57723|Acidobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K03319	-	-	-	-	ko00000	2.A.47	-	-	Na_sulph_symp
TLS2_k127_5660605_2	1280689.AUJC01000010_gene1875	4.838e-35	153.0	28MBK@1|root,2ZAQ1@2|Bacteria,1TSWC@1239|Firmicutes,24FTF@186801|Clostridia,36W4J@31979|Clostridiaceae	186801|Clostridia	M	Arylsulfotransferase Ig-like domain	-	-	2.8.2.22	ko:K01023	-	-	-	-	ko00000,ko01000	-	-	-	Arylsulfotran_N,Arylsulfotrans
TLS2_k127_5660605_4	1340493.JNIF01000003_gene3950	4.773e-07	57.0	COG0471@1|root,COG0471@2|Bacteria,3Y6TC@57723|Acidobacteria	57723|Acidobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K03319	-	-	-	-	ko00000	2.A.47	-	-	Na_sulph_symp
TLS2_k127_5661154_2	1267535.KB906767_gene3397	4.214e-39	147.0	COG1977@1|root,COG1977@2|Bacteria,3Y5J3@57723|Acidobacteria,2JJVU@204432|Acidobacteriia	204432|Acidobacteriia	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5661154_1	1122214.AQWH01000026_gene4856	6.612e-52	187.0	29XQK@1|root,30JGA@2|Bacteria,1NYWY@1224|Proteobacteria,2UT6B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5661154_4	1510531.JQJJ01000014_gene4727	1.782e-35	142.0	COG1846@1|root,COG1846@2|Bacteria,1N6YD@1224|Proteobacteria,2U0SG@28211|Alphaproteobacteria,3JSZ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	MA20_36885	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_5661154_0	1144275.COCOR_00104	1.271e-91	308.0	COG0500@1|root,COG2226@2|Bacteria,1RDQI@1224|Proteobacteria,42SIB@68525|delta/epsilon subdivisions,2WPCP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_5661154_3	234267.Acid_7413	1.276e-36	144.0	2E5J5@1|root,330AF@2|Bacteria,3Y5HZ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
TLS2_k127_5662484_2	861299.J421_4432	3.866e-17	83.0	COG1502@1|root,COG1502@2|Bacteria,1ZTU6@142182|Gemmatimonadetes	2|Bacteria	I	Phospholipase D. Active site motifs.	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
TLS2_k127_5662484_3	335543.Sfum_0932	6.931e-16	85.0	2E5ZM@1|root,330P1@2|Bacteria,1NAS6@1224|Proteobacteria,431GK@68525|delta/epsilon subdivisions,2WWT6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5662484_1	478741.JAFS01000001_gene1082	2.809e-18	87.0	2E5ZM@1|root,330P1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4276
TLS2_k127_5662484_0	478741.JAFS01000001_gene1081	1.95e-153	493.0	COG4637@1|root,COG4637@2|Bacteria	2|Bacteria	L	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21
TLS2_k127_5662484_4	234267.Acid_6834	3.279e-09	61.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_5666994_1	234267.Acid_1018	2.765e-84	281.0	COG0312@1|root,COG0312@2|Bacteria,3Y2TY@57723|Acidobacteria	57723|Acidobacteria	H	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	CoaE,PmbA_TldD
TLS2_k127_5666994_0	234267.Acid_1017	5.402e-131	434.0	COG0312@1|root,COG0312@2|Bacteria,3Y39N@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS2_k127_566819_1	1379698.RBG1_1C00001G1796	1.941e-41	165.0	2EFJT@1|root,339C3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_566819_3	1267535.KB906767_gene2015	4.93e-09	62.0	COG2801@1|root,COG2801@2|Bacteria,3Y821@57723|Acidobacteria	57723|Acidobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
TLS2_k127_566819_0	1214101.BN159_5242	6.488e-75	253.0	COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,2GX6F@201174|Actinobacteria	201174|Actinobacteria	Q	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,Tyrosinase,VCBS
TLS2_k127_5669302_7	234267.Acid_2169	8.736e-53	197.0	2EZ67@1|root,33SC9@2|Bacteria,3Y6G7@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5669302_0	234267.Acid_1498	1.399e-140	458.0	COG1030@1|root,COG1030@2|Bacteria,3Y31N@57723|Acidobacteria	57723|Acidobacteria	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
TLS2_k127_5669302_2	234267.Acid_1499	5.212e-112	367.0	COG0330@1|root,COG0330@2|Bacteria,3Y33E@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_5669302_4	518766.Rmar_2223	1.367e-94	317.0	COG0861@1|root,COG0861@2|Bacteria,4NFFD@976|Bacteroidetes,1FIQZ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Integral membrane protein TerC family	-	-	-	-	-	-	-	-	-	-	-	-	TerC
TLS2_k127_5669302_1	1267535.KB906767_gene3942	1.109e-134	437.0	COG0449@1|root,COG0449@2|Bacteria,3Y6GI@57723|Acidobacteria,2JKK5@204432|Acidobacteriia	204432|Acidobacteriia	M	Glutamine--fructose-6-phosphate aminotransferase isomerizing	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
TLS2_k127_5669302_3	234267.Acid_1600	2.663e-108	369.0	COG1450@1|root,COG1450@2|Bacteria,3Y6Z6@57723|Acidobacteria	57723|Acidobacteria	NU	Bacterial type II and III secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	Secretin
TLS2_k127_5669302_8	1123256.KB907945_gene368	2.447e-46	172.0	2BGHV@1|root,32AG3@2|Bacteria,1NCU1@1224|Proteobacteria,1T0UQ@1236|Gammaproteobacteria,1X8FV@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF3237)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3237
TLS2_k127_5669302_6	234267.Acid_2174	3.284e-70	251.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,Calx-beta,F5_F8_type_C,PA14,RicinB_lectin_2,Ricin_B_lectin,SdrD_B
TLS2_k127_5669302_9	204669.Acid345_4558	4.613e-26	125.0	COG3710@1|root,COG3710@2|Bacteria,3Y7KB@57723|Acidobacteria,2JMW2@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS2_k127_5669302_5	1267535.KB906767_gene5132	1.539e-84	307.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
TLS2_k127_5669302_12	667632.KB890164_gene1690	8.214e-07	53.0	COG5487@1|root,COG5487@2|Bacteria,1NGAH@1224|Proteobacteria,2VVY1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	UPF0391 membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1328
TLS2_k127_5674129_1	1382359.JIAL01000001_gene1598	2.331e-87	297.0	COG0438@1|root,COG0438@2|Bacteria,3Y67M@57723|Acidobacteria,2JKNE@204432|Acidobacteriia	204432|Acidobacteriia	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_5674129_0	234267.Acid_1822	1.72e-177	567.0	COG0531@1|root,COG0531@2|Bacteria,3Y7AX@57723|Acidobacteria	57723|Acidobacteria	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_5674129_2	234267.Acid_0316	2.224e-74	258.0	COG2094@1|root,COG2094@2|Bacteria,3Y5DM@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
TLS2_k127_5674129_4	99598.Cal7507_2858	1.396e-18	91.0	COG5499@1|root,COG5499@2|Bacteria,1G6YN@1117|Cyanobacteria,1HNWU@1161|Nostocales	1117|Cyanobacteria	K	COGs COG5499 transcription regulator containing HTH domain	-	-	-	ko:K18831	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	-
TLS2_k127_5674129_3	234267.Acid_3656	1.517e-30	122.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
TLS2_k127_5683141_1	234267.Acid_7942	8.83e-116	386.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,3Y6NP@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
TLS2_k127_5683141_4	1121921.KB898717_gene3446	5.466e-23	111.0	2DQ02@1|root,33460@2|Bacteria,1RJZN@1224|Proteobacteria	1224|Proteobacteria	S	RepB DNA-primase from phage plasmid	-	-	-	-	-	-	-	-	-	-	-	-	RepB_primase
TLS2_k127_5683141_5	768671.ThimaDRAFT_0503	8.158e-08	60.0	COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria,1SQA0@1236|Gammaproteobacteria,1X16W@135613|Chromatiales	1224|Proteobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5683141_0	1288826.MSNKSG1_03515	1.546e-127	421.0	COG4974@1|root,COG4974@2|Bacteria,1R72R@1224|Proteobacteria,1S8CW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_5683141_3	1041147.AUFB01000032_gene5860	3.636e-95	322.0	COG4974@1|root,COG4974@2|Bacteria,1QVIY@1224|Proteobacteria,2TZDI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_5683141_2	237609.PSAKL28_30590	6.439e-98	331.0	COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,1S4Y0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_5685999_6	1123368.AUIS01000006_gene560	5.631e-76	269.0	COG3861@1|root,COG3861@2|Bacteria,1RJWQ@1224|Proteobacteria,1T0VJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF2382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382
TLS2_k127_5685999_4	497964.CfE428DRAFT_4338	1.025e-182	583.0	COG2960@1|root,COG2960@2|Bacteria,46TXZ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
TLS2_k127_5685999_0	497964.CfE428DRAFT_4339	1.559e-284	898.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Condensation,PP-binding,PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5
TLS2_k127_5685999_1	344747.PM8797T_25446	7.826e-273	852.0	COG0492@1|root,COG0492@2|Bacteria,2J52X@203682|Planctomycetes	203682|Planctomycetes	O	secreted protein-putative xanthan lyase related	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_5685999_5	1396418.BATQ01000066_gene1614	2.836e-149	494.0	COG0492@1|root,COG0492@2|Bacteria,46U2N@74201|Verrucomicrobia,2IWJY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_5685999_2	1340493.JNIF01000003_gene3746	3.788e-267	836.0	COG1053@1|root,COG1053@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_oxidored,FMN_red,GIDA
TLS2_k127_5685999_3	1340493.JNIF01000003_gene4600	1.58e-258	836.0	COG1629@1|root,COG4771@2|Bacteria,3Y66U@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_5685999_7	521674.Plim_3234	0.0001478	53.0	COG0673@1|root,COG0673@2|Bacteria,2IXVF@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_568677_1	582744.Msip34_1757	7.426e-60	210.0	2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,2VQGY@28216|Betaproteobacteria,2KKNU@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Protein of unknown function (DUF4197)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4197
TLS2_k127_568677_2	768671.ThimaDRAFT_0512	2.431e-20	101.0	COG2823@1|root,COG2823@2|Bacteria,1N0SU@1224|Proteobacteria,1S926@1236|Gammaproteobacteria,1WZ45@135613|Chromatiales	135613|Chromatiales	S	periplasmic or secreted lipoprotein	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
TLS2_k127_568677_4	264198.Reut_B3815	2.364e-09	64.0	COG5510@1|root,COG5510@2|Bacteria,1P57A@1224|Proteobacteria	1224|Proteobacteria	S	Entericidin EcnA/B family	-	-	-	-	-	-	-	-	-	-	-	-	Entericidin
TLS2_k127_568677_3	1125863.JAFN01000001_gene3157	8.905e-15	76.0	2EAHN@1|root,334KU@2|Bacteria,1NAT6@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_568677_0	159450.NH14_30620	3.516e-215	676.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VZNG@28216|Betaproteobacteria,1K6IW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	similarity to GP 3192745	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
TLS2_k127_5689150_1	1379270.AUXF01000003_gene3729	1.139e-86	288.0	COG3508@1|root,COG3508@2|Bacteria,1ZTFN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	homogentisate 1,2-dioxygenase	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
TLS2_k127_5689150_0	211165.AJLN01000134_gene5775	7.477e-113	374.0	COG0179@1|root,COG0179@2|Bacteria,1G2C6@1117|Cyanobacteria,1JJVS@1189|Stigonemataceae	1117|Cyanobacteria	Q	Fumarylacetoacetase N-terminal	-	-	3.7.1.2	ko:K01555	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FAA_hydrolase,FAA_hydrolase_N
TLS2_k127_5689150_2	886293.Sinac_3180	2.483e-40	158.0	COG0671@1|root,COG0671@2|Bacteria,2J3BG@203682|Planctomycetes	203682|Planctomycetes	I	phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5689150_3	1300345.LF41_321	1.508e-05	51.0	COG1629@1|root,COG4771@2|Bacteria,1MW4X@1224|Proteobacteria,1RPVY@1236|Gammaproteobacteria,1X48Y@135614|Xanthomonadales	135614|Xanthomonadales	P	Outer membrane receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_5692884_6	1220551.SCHR_04175	1.358e-15	85.0	COG0500@1|root,COG2226@2|Bacteria,1TQEA@1239|Firmicutes,4HAR9@91061|Bacilli,4GWXZ@90964|Staphylococcaceae	91061|Bacilli	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS2_k127_5692884_5	215358.XP_010729294.1	1.243e-16	89.0	COG1028@1|root,KOG1200@2759|Eukaryota,38H67@33154|Opisthokonta,3BE5A@33208|Metazoa,3CU08@33213|Bilateria,48BJ4@7711|Chordata,493GG@7742|Vertebrata,4A1DE@7898|Actinopterygii	33208|Metazoa	Q	Carbonyl reductase	CBR4	GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008753,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016137,GO:0016491,GO:0016614,GO:0016616,GO:0016651,GO:0016655,GO:0016999,GO:0017144,GO:0019748,GO:0019752,GO:0022607,GO:0030638,GO:0030647,GO:0031974,GO:0032787,GO:0032991,GO:0034308,GO:0036094,GO:0042180,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044597,GO:0044598,GO:0046394,GO:0047025,GO:0048037,GO:0048038,GO:0050661,GO:0050662,GO:0051186,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051290,GO:0051291,GO:0055114,GO:0065003,GO:0070013,GO:0070402,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:0097164,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1901615,GO:1901657,GO:1901661,GO:1902494,GO:1902644,GO:1990204	-	ko:K11539	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
TLS2_k127_5692884_2	1267535.KB906767_gene105	2.362e-95	326.0	COG3307@1|root,COG3307@2|Bacteria,3Y67G@57723|Acidobacteria	57723|Acidobacteria	M	O-antigen ligase like membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TLS2_k127_5692884_3	1267535.KB906767_gene106	2.568e-53	192.0	COG2062@1|root,COG2062@2|Bacteria,3Y5YQ@57723|Acidobacteria	57723|Acidobacteria	T	Phosphoglycerate mutase family	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
TLS2_k127_5692884_1	383372.Rcas_3954	9.282e-129	421.0	COG0530@1|root,COG0530@2|Bacteria,2G6GV@200795|Chloroflexi,376V8@32061|Chloroflexia	32061|Chloroflexia	P	PFAM sodium calcium exchanger membrane region	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
TLS2_k127_5692884_4	234267.Acid_2615	8.698e-22	104.0	COG4796@1|root,COG4796@2|Bacteria	2|Bacteria	U	Type ii and iii secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin
TLS2_k127_5692884_0	344747.PM8797T_24981	8.268e-146	473.0	COG3119@1|root,COG3119@2|Bacteria,2IWX1@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
TLS2_k127_5695376_3	1340493.JNIF01000003_gene3584	3.222e-68	243.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS2_k127_5695376_2	1453503.AU05_00230	3.422e-75	256.0	COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,1S1ZX@1236|Gammaproteobacteria,1YDKN@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	G	Belongs to the pseudouridine synthase RsuA family	rluE	-	5.4.99.20,5.4.99.22	ko:K06178,ko:K06181	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
TLS2_k127_5695376_0	1267535.KB906767_gene3320	1.577e-315	984.0	COG4993@1|root,COG4993@2|Bacteria,3Y639@57723|Acidobacteria	57723|Acidobacteria	G	PQQ enzyme repeat	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ
TLS2_k127_5695376_1	1340493.JNIF01000003_gene1725	4.183e-77	267.0	COG0586@1|root,COG0586@2|Bacteria	2|Bacteria	S	FtsZ-dependent cytokinesis	dedA1	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
TLS2_k127_5695376_4	234267.Acid_0053	2.136e-47	181.0	COG0760@1|root,COG0760@2|Bacteria,3Y3BW@57723|Acidobacteria	57723|Acidobacteria	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
TLS2_k127_5703711_0	234267.Acid_1514	1.52e-184	599.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5714000_1	861299.J421_0248	1.991e-55	203.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,1ZUXK@142182|Gemmatimonadetes	2|Bacteria	T	AAA ATPase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Trans_reg_C
TLS2_k127_5714000_0	204669.Acid345_0730	0.0	1789.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,3Y415@57723|Acidobacteria,2JM30@204432|Acidobacteriia	204432|Acidobacteriia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,PFOR_II,POR,POR_N,TPP_enzyme_C
TLS2_k127_5714548_3	861299.J421_4375	2.845e-53	193.0	COG1595@1|root,COG1595@2|Bacteria,1ZTNR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_5714548_2	1121481.AUAS01000006_gene752	9.336e-65	229.0	COG0518@1|root,COG0518@2|Bacteria,4NTGJ@976|Bacteroidetes,47XUV@768503|Cytophagia	976|Bacteroidetes	F	Glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
TLS2_k127_5714548_0	1121481.AUAS01000006_gene751	6.962e-207	655.0	COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,47K4A@768503|Cytophagia	976|Bacteroidetes	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_5714548_1	604331.AUHY01000042_gene2019	1.23e-96	318.0	COG1028@1|root,COG1028@2|Bacteria,1WM8P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_5716200_0	1121123.AUAO01000003_gene2098	3.188e-45	169.0	2A97U@1|root,30YCI@2|Bacteria,1N16R@1224|Proteobacteria,2U8CT@28211|Alphaproteobacteria,2KJ6D@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5718076_2	502025.Hoch_2100	2.361e-34	135.0	COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,1P6RE@1224|Proteobacteria,43A2M@68525|delta/epsilon subdivisions,2X1XW@28221|Deltaproteobacteria,2YX2T@29|Myxococcales	28221|Deltaproteobacteria	I	Acetyl-CoA carboxylase, central region	-	-	-	-	-	-	-	-	-	-	-	-	ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
TLS2_k127_5718076_1	234267.Acid_3076	3.105e-45	175.0	COG2091@1|root,COG2091@2|Bacteria,3Y8HB@57723|Acidobacteria	57723|Acidobacteria	H	4'-phosphopantetheinyl transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_5718076_0	1267533.KB906734_gene3886	1.917e-49	181.0	COG0247@1|root,COG0247@2|Bacteria,3Y3K8@57723|Acidobacteria,2JKGH@204432|Acidobacteriia	204432|Acidobacteriia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
TLS2_k127_5718481_2	1267535.KB906767_gene3160	4.886e-82	276.0	COG1660@1|root,COG1660@2|Bacteria,3Y2HM@57723|Acidobacteria,2JHJM@204432|Acidobacteriia	204432|Acidobacteriia	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
TLS2_k127_5718481_4	1121033.AUCF01000014_gene1350	3.264e-27	117.0	2DN17@1|root,32UV9@2|Bacteria,1N33U@1224|Proteobacteria,2UC5D@28211|Alphaproteobacteria,2JTTN@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5718481_3	671143.DAMO_3017	4.833e-47	181.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	mhpC	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
TLS2_k127_5718481_1	1267535.KB906767_gene3329	1.33e-101	341.0	COG1533@1|root,COG1533@2|Bacteria,3Y2S5@57723|Acidobacteria,2JIC8@204432|Acidobacteriia	204432|Acidobacteriia	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_5718481_0	1267535.KB906767_gene3040	7.428e-119	391.0	COG0624@1|root,COG0624@2|Bacteria,3Y3J0@57723|Acidobacteria,2JI3Y@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase dimerisation domain	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_572611_0	278963.ATWD01000001_gene1577	1.726e-42	158.0	COG1695@1|root,COG1695@2|Bacteria,3Y873@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_5728749_0	1267535.KB906767_gene4837	1.684e-280	890.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_5728749_1	886293.Sinac_7120	2.219e-70	242.0	COG3386@1|root,COG3386@2|Bacteria,2IXCR@203682|Planctomycetes	203682|Planctomycetes	G	SMP-30/Gluconolaconase/LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
TLS2_k127_5739278_1	234267.Acid_2061	5.096e-94	317.0	COG3550@1|root,COG3550@2|Bacteria,3Y4V9@57723|Acidobacteria	57723|Acidobacteria	S	HipA N-terminal domain	-	-	2.7.11.1	ko:K07154	-	-	-	-	ko00000,ko01000,ko01001,ko02048	-	-	-	Couple_hipA,HipA_C
TLS2_k127_5739278_0	1384056.N787_06535	5.771e-155	496.0	COG3673@1|root,COG3673@2|Bacteria,1NFRW@1224|Proteobacteria,1RP20@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized alpha/beta hydrolase domain (DUF2235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2235
TLS2_k127_5739278_2	32057.KB217480_gene8334	5.11e-45	187.0	COG3591@1|root,COG4995@1|root,COG3591@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,Trypsin_2,WD40
TLS2_k127_5741181_1	234267.Acid_6547	1.195e-38	148.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_5741181_0	234267.Acid_6548	1.813e-236	740.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_574539_5	187272.Mlg_0270	3.503e-09	63.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales	135613|Chromatiales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_574539_1	1173026.Glo7428_4012	1.204e-132	432.0	COG3119@1|root,COG3119@2|Bacteria,1G5IZ@1117|Cyanobacteria	1117|Cyanobacteria	P	Arylsulfatase a	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase,Sulfatase_C
TLS2_k127_574539_3	234267.Acid_3958	1.342e-20	93.0	299QU@1|root,2ZWT2@2|Bacteria,3Y915@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_574539_0	1123368.AUIS01000009_gene2439	3.011e-156	524.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Glyco_hydro_77
TLS2_k127_574539_4	234267.Acid_0326	6.026e-14	75.0	COG1551@1|root,COG1551@2|Bacteria	2|Bacteria	T	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
TLS2_k127_574539_2	234267.Acid_0328	5.153e-24	104.0	COG1699@1|root,COG1699@2|Bacteria,3Y8Z8@57723|Acidobacteria	57723|Acidobacteria	S	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum	-	-	-	ko:K13626	-	-	-	-	ko00000,ko02035	-	-	-	FliW
TLS2_k127_5752118_0	1340493.JNIF01000004_gene1148	2.555e-232	729.0	COG0666@1|root,COG0666@2|Bacteria,3Y6UE@57723|Acidobacteria	57723|Acidobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2
TLS2_k127_5752118_1	1267535.KB906767_gene3646	3.728e-23	104.0	COG1961@1|root,COG1961@2|Bacteria,3Y5HT@57723|Acidobacteria,2JK3G@204432|Acidobacteriia	204432|Acidobacteriia	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_7,Resolvase
TLS2_k127_575387_0	234267.Acid_4106	3.863e-194	618.0	COG1807@1|root,COG1807@2|Bacteria,3Y404@57723|Acidobacteria	57723|Acidobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_575387_2	234267.Acid_4244	4.206e-98	331.0	COG0438@1|root,COG0438@2|Bacteria,3Y58K@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_575387_1	234267.Acid_7573	7.007e-104	354.0	COG1629@1|root,COG4771@2|Bacteria,3Y6Q2@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_5763108_0	1322246.BN4_12687	5.099e-132	438.0	COG0763@1|root,COG0763@2|Bacteria	2|Bacteria	M	lipid-A-disaccharide synthase activity	-	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	Capsule_synth
TLS2_k127_5763108_2	1122179.KB890424_gene3620	5.248e-20	103.0	COG1083@1|root,COG3980@1|root,COG1083@2|Bacteria,COG3980@2|Bacteria,4NRQW@976|Bacteroidetes	976|Bacteroidetes	M	Cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_3
TLS2_k127_5763108_1	1121439.dsat_1902	2.831e-44	172.0	COG0329@1|root,COG0329@2|Bacteria,1R4AY@1224|Proteobacteria,42Z2J@68525|delta/epsilon subdivisions,2WU4R@28221|Deltaproteobacteria,2MAXY@213115|Desulfovibrionales	28221|Deltaproteobacteria	EM	Dihydrodipicolinate synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	DHDPS
TLS2_k127_5763108_3	1121441.AUCX01000016_gene2328	8.397e-11	64.0	COG1052@1|root,COG1052@2|Bacteria,1QVZS@1224|Proteobacteria,43A0B@68525|delta/epsilon subdivisions,2X1TR@28221|Deltaproteobacteria,2MC2T@213115|Desulfovibrionales	28221|Deltaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_5765532_0	1192868.CAIU01000025_gene3627	4.054e-104	347.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2TQJJ@28211|Alphaproteobacteria,43HMQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_5765532_3	1267005.KB911260_gene3547	4.292e-60	216.0	COG2304@1|root,COG2304@2|Bacteria,1PBVT@1224|Proteobacteria,2U3NK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_5765532_1	1121033.AUCF01000009_gene1133	1.897e-91	306.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,2JRGA@204441|Rhodospirillales	204441|Rhodospirillales	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS2_k127_5765532_2	1144307.PMI04_03788	1.759e-63	224.0	COG1392@1|root,COG1392@2|Bacteria,1QV5N@1224|Proteobacteria,2TWA9@28211|Alphaproteobacteria,2K1CT@204457|Sphingomonadales	204457|Sphingomonadales	P	Phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	NUDIX,PhoU_div
TLS2_k127_5765532_4	1134912.AJTV01000007_gene1047	2.217e-32	128.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria,36XGF@31993|Methylocystaceae	28211|Alphaproteobacteria	P	Phosphate transporter family	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
TLS2_k127_5786543_2	471854.Dfer_0342	6.84e-63	218.0	COG2333@1|root,COG2333@2|Bacteria,4NH12@976|Bacteroidetes,47NEU@768503|Cytophagia	976|Bacteroidetes	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_5786543_0	1057002.KB905371_gene148	5.734e-194	612.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,4B8QI@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
TLS2_k127_5786543_1	394.NGR_a01870	4.538e-130	421.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,4BCFB@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
TLS2_k127_5786543_3	1379698.RBG1_1C00001G0608	1.999e-35	142.0	COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_16,TPR_2,TPR_8,TolB_N
TLS2_k127_5793488_0	1121937.AUHJ01000003_gene3215	1.264e-37	149.0	2CVK5@1|root,32SXS@2|Bacteria,1N0ZG@1224|Proteobacteria,1S9R3@1236|Gammaproteobacteria,467R6@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5793488_3	68170.KL590560_gene3998	2.286e-07	63.0	COG3386@1|root,COG3386@2|Bacteria,2I414@201174|Actinobacteria	201174|Actinobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5793488_2	555778.Hneap_2253	3.122e-19	98.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1N6EM@1224|Proteobacteria,1RMJ7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the ompA family	plpD	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA,OmpA_membrane,OprF,SmpA_OmlA
TLS2_k127_5793488_1	743836.AYNA01000125_gene1378	4.391e-25	111.0	COG1878@1|root,COG1878@2|Bacteria,1MWWB@1224|Proteobacteria,2TSIG@28211|Alphaproteobacteria,36Z2V@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_5805979_3	234267.Acid_1906	5.823e-79	282.0	COG1074@1|root,COG1074@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	-	-	3.1.11.5,3.6.4.12	ko:K01144,ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF3799,PDDEXK_1,UvrD-helicase,UvrD_C
TLS2_k127_5805979_2	234267.Acid_1905	5.875e-119	415.0	COG3857@1|root,COG3857@2|Bacteria	2|Bacteria	L	exonuclease activity	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
TLS2_k127_5805979_6	234267.Acid_7940	2.559e-35	144.0	COG1595@1|root,COG1595@2|Bacteria,3Y5K8@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_5805979_9	1267535.KB906767_gene4943	3.092e-07	61.0	291QZ@1|root,2ZPB0@2|Bacteria,3Y92F@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5805979_4	1340493.JNIF01000004_gene449	2.988e-77	261.0	COG0663@1|root,COG0663@2|Bacteria,3Y4A5@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
TLS2_k127_5805979_1	234267.Acid_1537	6.445e-189	598.0	COG0124@1|root,COG0124@2|Bacteria,3Y3IY@57723|Acidobacteria	57723|Acidobacteria	J	PFAM tRNA synthetase, class II (G, H, P and S)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TLS2_k127_5805979_0	1267535.KB906767_gene1021	1.052e-296	920.0	COG0173@1|root,COG0173@2|Bacteria,3Y3SP@57723|Acidobacteria,2JIRC@204432|Acidobacteriia	204432|Acidobacteriia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_2,tRNA_anti-codon
TLS2_k127_5805979_8	221359.RS9916_39376	1.526e-09	70.0	COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H438@1129|Synechococcus	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
TLS2_k127_5805979_5	1267535.KB906767_gene3810	6.474e-67	235.0	COG0457@1|root,COG0457@2|Bacteria	1267535.KB906767_gene3810|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5808996_0	1267535.KB906767_gene4125	1.586e-179	573.0	COG4299@1|root,COG4299@2|Bacteria,3Y3Q4@57723|Acidobacteria	57723|Acidobacteria	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5808996_1	575540.Isop_3679	2.024e-134	440.0	COG3119@1|root,COG3119@2|Bacteria,2IYH5@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.4	ko:K01132	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00077,M00079	R07806	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
TLS2_k127_5808996_4	518766.Rmar_1391	6.103e-65	231.0	COG0684@1|root,COG0684@2|Bacteria	2|Bacteria	H	ribonuclease inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
TLS2_k127_5808996_3	1121377.KB906411_gene455	1.253e-117	385.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	yfhM	-	-	ko:K22369	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Abhydrolase_1
TLS2_k127_5808996_5	926569.ANT_25800	4.017e-40	153.0	28KCX@1|root,2Z9ZQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5811439_4	1340493.JNIF01000004_gene762	2.748e-47	174.0	COG1879@1|root,COG1879@2|Bacteria,3Y872@57723|Acidobacteria	57723|Acidobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TLS2_k127_5811439_3	1267535.KB906767_gene4996	6.617e-72	257.0	2EKZZ@1|root,33EPG@2|Bacteria,3Y5U9@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Lipase_GDSL_2
TLS2_k127_5811439_0	234267.Acid_2483	2.167e-205	645.0	COG0172@1|root,COG0172@2|Bacteria,3Y2UD@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TLS2_k127_5811439_1	1356854.N007_09645	9.691e-139	450.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,4H9YE@91061|Bacilli,278TC@186823|Alicyclobacillaceae	91061|Bacilli	C	Citrate synthase, C-terminal domain	citZ	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS2_k127_5811439_2	234267.Acid_3687	1.409e-98	331.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,3Y34Y@57723|Acidobacteria	57723|Acidobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
TLS2_k127_5821381_2	234267.Acid_0980	1.031e-51	193.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,CHAT,LCAT
TLS2_k127_5821381_1	886293.Sinac_5427	2.218e-63	226.0	COG3485@1|root,COG3485@2|Bacteria,2IYK6@203682|Planctomycetes	203682|Planctomycetes	Q	PFAM intradiol ring-cleavage dioxygenase	-	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
TLS2_k127_5821381_0	1123278.KB893574_gene6154	4.842e-73	256.0	COG2173@1|root,COG2173@2|Bacteria	2|Bacteria	M	zinc D-Ala-D-Ala carboxypeptidase activity	-	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15,SH3_3,SH3_4,VanY
TLS2_k127_5825071_0	234267.Acid_1154	9.006e-77	282.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_5825071_1	1267533.KB906740_gene287	8.175e-10	72.0	COG0457@1|root,COG0823@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	DUF4214,SBBP,TPR_19
TLS2_k127_5828199_1	234267.Acid_7533	6.513e-85	285.0	COG3622@1|root,COG3622@2|Bacteria,3Y5NQ@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_5828199_0	234267.Acid_0594	3.619e-134	435.0	COG0823@1|root,COG0823@2|Bacteria,3Y36H@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
TLS2_k127_5828199_2	240016.ABIZ01000001_gene4738	5.813e-25	108.0	COG3182@1|root,COG3182@2|Bacteria,46VJZ@74201|Verrucomicrobia,2IVK9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	PepSY-associated TM region	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_TM
TLS2_k127_5833701_2	1267535.KB906767_gene5078	2.45e-76	263.0	COG3182@1|root,COG3182@2|Bacteria	2|Bacteria	E	Iron-regulated membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_TM
TLS2_k127_5833701_0	234267.Acid_3094	3.633e-103	357.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y59I@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5833701_1	1267535.KB906767_gene3106	8.919e-81	278.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_5839890_0	234267.Acid_7465	2.252e-192	612.0	COG1298@1|root,COG1298@2|Bacteria,3Y3YR@57723|Acidobacteria	57723|Acidobacteria	NU	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
TLS2_k127_5839890_9	234267.Acid_7466	3.935e-52	198.0	COG1419@1|root,COG1419@2|Bacteria,3Y7V1@57723|Acidobacteria	57723|Acidobacteria	N	SRP54-type protein, GTPase domain	-	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
TLS2_k127_5839890_5	1340493.JNIF01000003_gene3261	2.696e-73	254.0	COG1191@1|root,COG1191@2|Bacteria,3Y4Q5@57723|Acidobacteria	57723|Acidobacteria	K	TIGRFAM RNA polymerase sigma factor, FliA WhiG family	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_5839890_3	1340493.JNIF01000003_gene4005	1.201e-84	291.0	COG1868@1|root,COG1868@2|Bacteria,3Y49R@57723|Acidobacteria	57723|Acidobacteria	N	flagellar motor switch protein FliM	-	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
TLS2_k127_5839890_10	1340493.JNIF01000003_gene2692	2.274e-42	160.0	COG2825@1|root,COG2825@2|Bacteria,3Y8ID@57723|Acidobacteria	57723|Acidobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
TLS2_k127_5839890_14	1267535.KB906767_gene3604	2.334e-16	80.0	COG1582@1|root,COG1582@2|Bacteria,3Y5M5@57723|Acidobacteria	57723|Acidobacteria	N	PFAM flagellar FlbD family protein	-	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
TLS2_k127_5839890_4	234267.Acid_0332	6.707e-76	265.0	COG1291@1|root,COG1291@2|Bacteria,3Y2VA@57723|Acidobacteria	57723|Acidobacteria	N	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
TLS2_k127_5839890_6	234267.Acid_0331	1.377e-69	245.0	COG1360@1|root,COG1360@2|Bacteria,3Y4KZ@57723|Acidobacteria	57723|Acidobacteria	N	PFAM OmpA	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
TLS2_k127_5839890_1	234267.Acid_7145	3.161e-113	383.0	COG2204@1|root,COG2204@2|Bacteria,3Y6BK@57723|Acidobacteria	57723|Acidobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
TLS2_k127_5839890_11	234267.Acid_7468	2.863e-42	166.0	COG1886@1|root,COG1886@2|Bacteria,3Y5N4@57723|Acidobacteria	57723|Acidobacteria	NU	Type III flagellar switch regulator (C-ring) FliN C-term	-	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
TLS2_k127_5839890_2	234267.Acid_7143	2.85e-93	324.0	COG1256@1|root,COG1256@2|Bacteria,3Y2GW@57723|Acidobacteria	57723|Acidobacteria	N	TIGRFAM flagellar hook-associated protein FlgK	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TLS2_k127_5839890_8	234267.Acid_7142	5.715e-54	201.0	COG1344@1|root,COG1344@2|Bacteria,3Y4HH@57723|Acidobacteria	57723|Acidobacteria	N	Bacterial flagellin N-terminal helical region	-	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
TLS2_k127_5839890_12	234267.Acid_0337	7.155e-34	134.0	COG1815@1|root,COG1815@2|Bacteria,3Y5BH@57723|Acidobacteria	57723|Acidobacteria	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	-	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
TLS2_k127_5839890_7	234267.Acid_0338	2.704e-55	196.0	COG1558@1|root,COG1558@2|Bacteria,3Y538@57723|Acidobacteria	57723|Acidobacteria	N	flagellar basal-body rod protein FlgC	-	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TLS2_k127_5843702_5	318996.AXAZ01000004_gene6113	2.109e-38	152.0	COG2114@1|root,COG2114@2|Bacteria,1QWKB@1224|Proteobacteria,2TX0H@28211|Alphaproteobacteria,3K6RB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,GerE,Guanylate_cyc,Hydrolase_4
TLS2_k127_5843702_2	1173026.Glo7428_0940	9.302e-120	399.0	COG0654@1|root,COG0654@2|Bacteria,1G27V@1117|Cyanobacteria	1117|Cyanobacteria	CH	Monooxygenase fad-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5843702_8	234267.Acid_1093	1.301e-16	80.0	COG0230@1|root,COG0230@2|Bacteria,3Y5W7@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
TLS2_k127_5843702_7	1267534.KB906758_gene2190	1.129e-17	87.0	COG0594@1|root,COG0594@2|Bacteria,3Y5EK@57723|Acidobacteria,2JJTR@204432|Acidobacteriia	204432|Acidobacteriia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
TLS2_k127_5843702_6	861452.HMPREF9093_00370	1.833e-23	105.0	COG0759@1|root,COG0759@2|Bacteria,37AZG@32066|Fusobacteria	32066|Fusobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
TLS2_k127_5843702_1	234267.Acid_1090	2.658e-163	531.0	COG0706@1|root,COG0706@2|Bacteria,3Y3TD@57723|Acidobacteria	57723|Acidobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
TLS2_k127_5843702_4	1267535.KB906767_gene3478	4.129e-59	211.0	COG1847@1|root,COG1847@2|Bacteria,3Y52C@57723|Acidobacteria,2JJF9@204432|Acidobacteriia	204432|Acidobacteriia	S	R3H domain	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	R3H
TLS2_k127_5843702_0	234267.Acid_1088	6.766e-178	569.0	COG0486@1|root,COG0486@2|Bacteria,3Y3QJ@57723|Acidobacteria	57723|Acidobacteria	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
TLS2_k127_5843702_3	1095769.CAHF01000022_gene253	8.47e-111	371.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_5847609_1	1340493.JNIF01000003_gene4569	9.453e-91	311.0	COG3356@1|root,COG3356@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
TLS2_k127_5847609_0	1267535.KB906767_gene2601	2.966e-111	366.0	COG0265@1|root,COG0265@2|Bacteria,3Y3HE@57723|Acidobacteria,2JHN5@204432|Acidobacteriia	204432|Acidobacteriia	O	peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_5848686_7	273068.TTE0658	1.18e-75	267.0	COG0438@1|root,COG0438@2|Bacteria,1TPS8@1239|Firmicutes,24IX5@186801|Clostridia	186801|Clostridia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_5848686_8	743525.TSC_c02960	2.966e-68	250.0	COG0438@1|root,COG0438@2|Bacteria,1WJN6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_5848686_9	1121935.AQXX01000136_gene4015	4.742e-18	95.0	COG0500@1|root,COG3039@1|root,COG2226@2|Bacteria,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,1XME3@135619|Oceanospirillales	135619|Oceanospirillales	L	COG3039 Transposase and inactivated derivatives IS5 family	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
TLS2_k127_5848686_5	665571.STHERM_c15680	3.099e-93	319.0	COG0438@1|root,COG0438@2|Bacteria,2J8DI@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1
TLS2_k127_5848686_6	604331.AUHY01000039_gene98	9.412e-77	263.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1WIX1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	GM	COGs COG2148 Sugar transferase involved in lipopolysaccharide synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS2_k127_5848686_1	1382359.JIAL01000001_gene2469	1.03e-206	652.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria,2JICQ@204432|Acidobacteriia	204432|Acidobacteriia	T	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_5848686_3	639030.JHVA01000001_gene2859	1.964e-102	346.0	COG4191@1|root,COG4191@2|Bacteria,3Y5DB@57723|Acidobacteria,2JJS0@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_5848686_4	1382359.JIAL01000001_gene2467	2.788e-96	331.0	COG1538@1|root,COG1538@2|Bacteria,3Y66Y@57723|Acidobacteria,2JKJ4@204432|Acidobacteriia	204432|Acidobacteriia	MU	Outer membrane efflux protein	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
TLS2_k127_5848686_2	1340493.JNIF01000003_gene2433	1.173e-103	349.0	COG0845@1|root,COG0845@2|Bacteria,3Y6F8@57723|Acidobacteria	57723|Acidobacteria	M	HlyD family secretion protein	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
TLS2_k127_5848686_0	1340493.JNIF01000003_gene2434	0.0	1325.0	COG3696@1|root,COG3696@2|Bacteria,3Y6TG@57723|Acidobacteria	57723|Acidobacteria	P	AcrB/AcrD/AcrF family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
TLS2_k127_5848927_4	103690.17132648	1.294e-28	119.0	29X8Z@1|root,30IYE@2|Bacteria,1G6D1@1117|Cyanobacteria,1HRJ7@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5848927_0	644966.Tmar_1638	1.905e-187	601.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,3WCWS@538999|Clostridiales incertae sedis	186801|Clostridia	H	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS2_k127_5848927_3	861299.J421_2350	7.303e-35	153.0	COG4249@1|root,COG5492@1|root,COG4249@2|Bacteria,COG5492@2|Bacteria,1ZUYG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5848927_1	1340493.JNIF01000003_gene3456	1.29e-78	283.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_5855841_1	247490.KSU1_C0634	3.056e-73	261.0	COG0628@1|root,COG0628@2|Bacteria,2J2TA@203682|Planctomycetes	203682|Planctomycetes	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_5855841_0	530564.Psta_0408	9.241e-134	436.0	COG3540@1|root,COG3540@2|Bacteria,2IX0A@203682|Planctomycetes	203682|Planctomycetes	P	Alkaline phosphatase	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
TLS2_k127_5860045_0	204669.Acid345_2986	3.971e-107	353.0	COG0580@1|root,COG0580@2|Bacteria,3Y3AE@57723|Acidobacteria,2JIP3@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K02440	-	-	-	-	ko00000,ko02000	1.A.8.1,1.A.8.2	-	-	MIP
TLS2_k127_5860045_1	234267.Acid_5870	8.052e-104	348.0	COG1082@1|root,COG1082@2|Bacteria,3Y7AM@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_5860969_0	234267.Acid_1231	2.247e-233	728.0	COG1069@1|root,COG1069@2|Bacteria,3Y3B6@57723|Acidobacteria	57723|Acidobacteria	C	PFAM carbohydrate kinase	-	-	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100	-	R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
TLS2_k127_5860969_1	595460.RRSWK_02086	1.357e-06	52.0	COG3055@1|root,COG5492@1|root,COG3055@2|Bacteria,COG5492@2|Bacteria,2IYV9@203682|Planctomycetes	203682|Planctomycetes	N	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF5060
TLS2_k127_5867600_1	1340493.JNIF01000004_gene597	2.768e-104	362.0	COG1629@1|root,COG1629@2|Bacteria,3Y6Z5@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_5867600_2	525904.Tter_2776	3.638e-77	284.0	COG2730@1|root,COG3386@1|root,COG5492@1|root,COG2730@2|Bacteria,COG3386@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	3.1.1.15	ko:K13874,ko:K22217	ko00053,ko01100,map00053,map01100	-	R02526	RC00537	ko00000,ko00001,ko01000	-	-	-	SGL
TLS2_k127_5867600_0	1380394.JADL01000022_gene4	8.464e-110	370.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TUKZ@28211|Alphaproteobacteria,2JW26@204441|Rhodospirillales	204441|Rhodospirillales	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
TLS2_k127_5869217_0	234267.Acid_3077	1.09e-249	784.0	COG0304@1|root,COG3321@1|root,COG4221@1|root,COG0304@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,3Y347@57723|Acidobacteria	57723|Acidobacteria	Q	Acyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
TLS2_k127_5878174_1	234267.Acid_0669	6.47e-100	335.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS2_k127_5878174_0	1340493.JNIF01000003_gene2725	5.317e-199	629.0	COG0277@1|root,COG0277@2|Bacteria,3Y6C5@57723|Acidobacteria	57723|Acidobacteria	C	PFAM FAD linked oxidase	-	-	1.1.3.41	ko:K00594	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R07152,R11620	RC00108,RC00133	ko00000,ko00001,ko01000	-	-	-	ALO,FAD_binding_4
TLS2_k127_5878633_0	1340493.JNIF01000003_gene1814	1.5e-323	1001.0	COG3485@1|root,COG3485@2|Bacteria,3Y3FU@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_5879027_0	234267.Acid_6973	0.0	1004.0	COG1966@1|root,COG1966@2|Bacteria,3Y436@57723|Acidobacteria	57723|Acidobacteria	T	5TM C-terminal transporter carbon starvation CstA	-	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
TLS2_k127_5879027_1	234267.Acid_6397	1.397e-138	451.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria	2|Bacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890,ko:K06878	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,RNA_ligase,tRNA_bind
TLS2_k127_5880746_1	1340493.JNIF01000004_gene597	1.366e-93	329.0	COG1629@1|root,COG1629@2|Bacteria,3Y6Z5@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_5880746_0	234267.Acid_5471	4.943e-120	401.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y6C0@57723|Acidobacteria	57723|Acidobacteria	KLTU	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
TLS2_k127_588220_2	794846.AJQU01000192_gene4785	1.509e-07	57.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2TVFI@28211|Alphaproteobacteria,4B7J0@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	DNA invertase Pin	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_588220_0	1267535.KB906767_gene5374	1.177e-292	904.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_588220_1	391626.OAN307_c30640	1.865e-65	226.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TS16@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG1484 DNA replication protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
TLS2_k127_5883044_4	344747.PM8797T_08689	1.515e-19	94.0	COG1028@1|root,COG1028@2|Bacteria,2IZC3@203682|Planctomycetes	203682|Planctomycetes	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_5883044_0	1232410.KI421421_gene3777	2.88e-168	542.0	COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,43SZU@69541|Desulfuromonadales	28221|Deltaproteobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
TLS2_k127_5883044_3	1089550.ATTH01000001_gene2136	1.488e-21	95.0	arCOG04557@1|root,32Y6Q@2|Bacteria,4NYUX@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5883044_2	321327.CYA_1492	2.992e-60	213.0	COG2343@1|root,COG2343@2|Bacteria,1G50P@1117|Cyanobacteria,1H0J9@1129|Synechococcus	1117|Cyanobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
TLS2_k127_5883044_1	1210884.HG799464_gene10536	1.658e-104	347.0	COG1453@1|root,COG1453@2|Bacteria,2IZF3@203682|Planctomycetes	203682|Planctomycetes	S	aldo keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_5887391_0	1267535.KB906767_gene2284	4.825e-82	284.0	COG1994@1|root,COG1994@2|Bacteria,3Y4IT@57723|Acidobacteria,2JMSE@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5887391_2	1340493.JNIF01000003_gene4518	3.173e-45	165.0	COG0776@1|root,COG0776@2|Bacteria,3Y55Y@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the bacterial histone-like protein family	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_5887391_3	234267.Acid_5167	2.928e-42	160.0	COG1853@1|root,COG1853@2|Bacteria	2|Bacteria	S	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	FCD,Flavin_Reduct
TLS2_k127_5887391_1	1121403.AUCV01000013_gene3928	8.12e-61	214.0	COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,42T9C@68525|delta/epsilon subdivisions,2WP3Z@28221|Deltaproteobacteria,2MKTX@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_5890467_3	243231.GSU0034	1.681e-115	383.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,43U2H@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_5890467_4	234267.Acid_0733	1.843e-47	177.0	COG0576@1|root,COG0576@2|Bacteria,3Y54K@57723|Acidobacteria	57723|Acidobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS2_k127_5890467_2	1267535.KB906767_gene3548	8.181e-126	412.0	COG1420@1|root,COG1420@2|Bacteria,3Y2JI@57723|Acidobacteria,2JI0D@204432|Acidobacteriia	204432|Acidobacteriia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
TLS2_k127_5890467_0	234267.Acid_5816	6.279e-292	914.0	COG0339@1|root,COG0339@2|Bacteria,3Y3U9@57723|Acidobacteria	57723|Acidobacteria	E	PFAM peptidase	-	-	3.4.15.5,3.4.24.70	ko:K01284,ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
TLS2_k127_5890467_5	1123368.AUIS01000005_gene413	1.765e-23	111.0	COG3652@1|root,COG3652@2|Bacteria,1N6QU@1224|Proteobacteria,1T0P2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4142
TLS2_k127_5890467_1	1340493.JNIF01000003_gene4275	3.426e-127	420.0	COG1629@1|root,COG4771@2|Bacteria,3Y6PD@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_5893958_0	1267533.KB906738_gene2168	8.665e-109	370.0	COG0534@1|root,COG0534@2|Bacteria,3Y2U1@57723|Acidobacteria,2JIPP@204432|Acidobacteriia	204432|Acidobacteriia	V	efflux protein, MATE family	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
TLS2_k127_5893958_1	589873.EP13_05530	1.302e-05	52.0	COG1629@1|root,COG4771@2|Bacteria,1MW4X@1224|Proteobacteria,1RPVY@1236|Gammaproteobacteria,465N5@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_5895285_4	1340493.JNIF01000003_gene4012	2.043e-53	194.0	COG1407@1|root,COG1407@2|Bacteria	2|Bacteria	S	Calcineurin-like phosphoesterase	MA20_22045	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
TLS2_k127_5895285_0	1340493.JNIF01000003_gene4011	6.42e-308	964.0	COG1201@1|root,COG1201@2|Bacteria,3Y348@57723|Acidobacteria	57723|Acidobacteria	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
TLS2_k127_5895285_1	1340493.JNIF01000003_gene4010	7.406e-189	604.0	COG1793@1|root,COG1793@2|Bacteria,3Y3AP@57723|Acidobacteria	57723|Acidobacteria	L	DNA ligase	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
TLS2_k127_5895285_2	1340493.JNIF01000003_gene4009	6.878e-122	399.0	COG1236@1|root,COG1236@2|Bacteria	2|Bacteria	J	nucleic acid phosphodiester bond hydrolysis	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K07577,ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N,Lactamase_B_2,RMMBL
TLS2_k127_5895285_3	196490.AUEZ01000036_gene6081	6.339e-72	254.0	COG3828@1|root,COG3828@2|Bacteria,1R5XA@1224|Proteobacteria,2U51F@28211|Alphaproteobacteria,3K5VQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	GSDH,ThuA
TLS2_k127_5904510_1	1340493.JNIF01000003_gene1440	1.236e-34	143.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	4.2.2.3	ko:K01729	ko00051,map00051	-	R03706	-	ko00000,ko00001,ko01000	-	-	-	Beta_helix,Chondroitinas_B
TLS2_k127_5904510_3	290397.Adeh_3857	2.963e-13	77.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42M0A@68525|delta/epsilon subdivisions,2X3DN@28221|Deltaproteobacteria,2YZFD@29|Myxococcales	28221|Deltaproteobacteria	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TLS2_k127_5904510_4	426355.Mrad2831_1233	2.069e-06	58.0	29FDW@1|root,2ZXKR@2|Bacteria,1PQE3@1224|Proteobacteria,2V2T4@28211|Alphaproteobacteria,1JYW7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5904510_0	1299327.I546_6183	1.937e-49	180.0	COG1848@1|root,COG1848@2|Bacteria,2IJ89@201174|Actinobacteria,239HU@1762|Mycobacteriaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0005575,GO:0005576	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_590683_1	926566.Terro_3037	1.244e-252	820.0	COG1629@1|root,COG3485@1|root,COG3485@2|Bacteria,COG4771@2|Bacteria,3Y477@57723|Acidobacteria,2JHX2@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_590683_0	1340493.JNIF01000003_gene4529	0.0	1444.0	COG3485@1|root,COG3485@2|Bacteria,3Y3FU@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_590683_2	639030.JHVA01000001_gene1797	5.432e-106	372.0	COG1629@1|root,COG1629@2|Bacteria,3Y39E@57723|Acidobacteria,2JIU9@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_591071_2	1234664.AMRO01000027_gene1420	1.33e-23	102.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,1WF0Q@129337|Geobacillus	91061|Bacilli	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS2_k127_591071_0	234267.Acid_7215	3.802e-201	640.0	COG0624@1|root,COG0624@2|Bacteria,3Y3TZ@57723|Acidobacteria	57723|Acidobacteria	E	peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_591071_1	1340493.JNIF01000004_gene68	1.237e-184	587.0	COG0114@1|root,COG0114@2|Bacteria,3Y9AP@57723|Acidobacteria	57723|Acidobacteria	C	Fumarase C C-terminus	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
TLS2_k127_592681_1	562970.Btus_2748	1.39e-48	190.0	COG4974@1|root,COG4974@2|Bacteria,1U0MD@1239|Firmicutes,4HF94@91061|Bacilli	91061|Bacilli	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
TLS2_k127_592681_0	1472716.KBK24_0123525	2.369e-49	192.0	COG0582@1|root,COG0582@2|Bacteria,1RD9B@1224|Proteobacteria	1224|Proteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_592681_2	391595.RLO149_c010940	2.271e-38	152.0	COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2U0B6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_5930704_8	1121106.JQKB01000032_gene4457	5.811e-09	70.0	COG2340@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2JSXK@204441|Rhodospirillales	204441|Rhodospirillales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,FecR,HemolysinCabind,Laminin_G_3
TLS2_k127_5930704_2	234267.Acid_0554	1.347e-97	359.0	COG1404@1|root,COG1404@2|Bacteria,3Y2EZ@57723|Acidobacteria	57723|Acidobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
TLS2_k127_5930704_4	1166948.JPZL01000001_gene2227	3.347e-51	188.0	COG2323@1|root,COG2323@2|Bacteria,1MW5I@1224|Proteobacteria,1S44G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
TLS2_k127_5930704_5	269799.Gmet_0036	1.002e-46	175.0	28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,42R46@68525|delta/epsilon subdivisions,2WMF2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
TLS2_k127_5930704_3	316067.Geob_1640	2.528e-79	270.0	COG3861@1|root,COG3861@2|Bacteria,1QYWN@1224|Proteobacteria,43E8W@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
TLS2_k127_5930704_9	357808.RoseRS_2469	1.919e-06	58.0	COG1404@1|root,COG1404@2|Bacteria,2G7GP@200795|Chloroflexi,375SG@32061|Chloroflexia	32061|Chloroflexia	O	TIGRFAM LPXTG-motif cell wall anchor domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
TLS2_k127_5930704_6	1267535.KB906767_gene446	6.896e-45	173.0	COG1974@1|root,COG1974@2|Bacteria,3Y813@57723|Acidobacteria	57723|Acidobacteria	KT	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5930704_0	234267.Acid_1229	1.975e-191	608.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_5930704_7	234267.Acid_2578	7.979e-39	149.0	COG2947@1|root,COG2947@2|Bacteria,3Y54W@57723|Acidobacteria	57723|Acidobacteria	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
TLS2_k127_5934742_1	1121920.AUAU01000008_gene1607	1.311e-109	368.0	COG0243@1|root,COG0243@2|Bacteria,3Y2HB@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TLS2_k127_5934742_0	234267.Acid_2929	0.0	1023.0	COG2223@1|root,COG2223@2|Bacteria,3Y4CF@57723|Acidobacteria	57723|Acidobacteria	P	nitrite transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_5934742_2	1185876.BN8_00013	2.721e-59	211.0	COG1735@1|root,COG1735@2|Bacteria,4NJYF@976|Bacteroidetes,47NZQ@768503|Cytophagia	976|Bacteroidetes	S	Phosphotriesterase family	php	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
TLS2_k127_5935771_2	1122182.KB903834_gene5918	0.0002817	44.0	COG1051@1|root,COG1051@2|Bacteria,2IQEA@201174|Actinobacteria,4DE0K@85008|Micromonosporales	201174|Actinobacteria	F	NUDIX domain	mutT2	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS2_k127_5935771_0	1122134.KB893651_gene2046	2.598e-224	718.0	COG1506@1|root,COG1506@2|Bacteria,1P6E1@1224|Proteobacteria,1RPRK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	peptidase	dpp4	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
TLS2_k127_5935771_1	388467.A19Y_2753	2.357e-44	166.0	COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria,1H87F@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_5947175_0	1173024.KI912154_gene1139	4.283e-127	416.0	COG0438@1|root,COG0438@2|Bacteria,1G1X1@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_5947175_1	1173028.ANKO01000030_gene3286	3.113e-93	317.0	COG0673@1|root,COG0673@2|Bacteria,1G18V@1117|Cyanobacteria,1HG44@1150|Oscillatoriales	1117|Cyanobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.1.335,1.1.99.28	ko:K00118,ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_5947175_2	1396418.BATQ01000019_gene4973	1.522e-87	304.0	COG0451@1|root,COG0451@2|Bacteria,46SJG@74201|Verrucomicrobia,2IUH1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,GDP_Man_Dehyd
TLS2_k127_5947175_3	279714.FuraDRAFT_0229	8.733e-12	70.0	COG0438@1|root,COG0438@2|Bacteria,1MYJ6@1224|Proteobacteria,2VRG3@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4
TLS2_k127_5947175_4	1340493.JNIF01000004_gene318	3.521e-10	70.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat
TLS2_k127_5947175_5	573061.Clocel_0562	0.0002909	51.0	COG3209@1|root,COG3227@1|root,COG3209@2|Bacteria,COG3227@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia,36F1J@31979|Clostridiaceae	186801|Clostridia	M	YD repeat (two copies)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,RHS_repeat
TLS2_k127_5950228_3	1121481.AUAS01000001_gene4718	3.665e-115	380.0	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,47K02@768503|Cytophagia	976|Bacteroidetes	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_5950228_5	1267535.KB906767_gene2869	8.244e-43	161.0	COG1765@1|root,COG1765@2|Bacteria,3Y55G@57723|Acidobacteria,2JK2F@204432|Acidobacteriia	204432|Acidobacteriia	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_5950228_0	234267.Acid_1034	1.043e-246	773.0	COG1190@1|root,COG1190@2|Bacteria,3Y3N0@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
TLS2_k127_5950228_2	1267535.KB906767_gene968	5.116e-143	465.0	COG4591@1|root,COG4591@2|Bacteria,3Y3BU@57723|Acidobacteria,2JIC6@204432|Acidobacteriia	204432|Acidobacteriia	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
TLS2_k127_5950228_1	1340493.JNIF01000003_gene3509	7.274e-244	767.0	COG0367@1|root,COG0367@2|Bacteria,3Y6CC@57723|Acidobacteria	57723|Acidobacteria	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
TLS2_k127_5950228_4	234267.Acid_4106	1.544e-50	187.0	COG1807@1|root,COG1807@2|Bacteria,3Y404@57723|Acidobacteria	57723|Acidobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_5956452_2	156889.Mmc1_2624	3.193e-07	53.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,2U24Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
TLS2_k127_5956452_1	502025.Hoch_0991	1.465e-20	96.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,4313Z@68525|delta/epsilon subdivisions,2WX2K@28221|Deltaproteobacteria,2Z2QP@29|Myxococcales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_5956452_0	502025.Hoch_2959	3.018e-59	209.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,4313Z@68525|delta/epsilon subdivisions,2WX2K@28221|Deltaproteobacteria,2Z2QP@29|Myxococcales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_5965491_0	1267535.KB906767_gene2434	1.977e-124	408.0	COG0758@1|root,COG0758@2|Bacteria,3Y42M@57723|Acidobacteria,2JI6N@204432|Acidobacteriia	204432|Acidobacteriia	LU	DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
TLS2_k127_5965491_1	1340493.JNIF01000003_gene3241	1.137e-57	211.0	COG0377@1|root,COG0377@2|Bacteria,3Y475@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TLS2_k127_5971224_0	1267535.KB906767_gene2417	3.653e-69	242.0	COG1484@1|root,COG1484@2|Bacteria,3Y3EK@57723|Acidobacteria,2JI9M@204432|Acidobacteriia	204432|Acidobacteriia	L	IstB-like ATP binding protein	-	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
TLS2_k127_5971224_1	240015.ACP_2133	7.121e-22	98.0	COG4770@1|root,COG4770@2|Bacteria,3Y5TC@57723|Acidobacteria,2JNZR@204432|Acidobacteriia	204432|Acidobacteriia	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
TLS2_k127_5987185_1	234267.Acid_6646	3.207e-55	196.0	COG0641@1|root,COG0641@2|Bacteria,3Y8KB@57723|Acidobacteria	57723|Acidobacteria	C	Radical SAM superfamily	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Radical_SAM,SPASM
TLS2_k127_5987185_0	1123368.AUIS01000024_gene953	2.114e-55	200.0	COG2890@1|root,COG2890@2|Bacteria,1MY5I@1224|Proteobacteria,1T26C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31,PrmA
TLS2_k127_5987185_3	1267535.KB906767_gene9	2.402e-19	95.0	COG0810@1|root,COG0810@2|Bacteria,3Y4BU@57723|Acidobacteria,2JJ3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
TLS2_k127_5987185_2	639030.JHVA01000001_gene2810	2.154e-22	102.0	COG2267@1|root,COG3710@1|root,COG2267@2|Bacteria,COG3710@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Abhydrolase_1,GerE,Trans_reg_C
TLS2_k127_5991119_6	204669.Acid345_0891	9.374e-05	51.0	COG3307@1|root,COG3307@2|Bacteria,3Y3R7@57723|Acidobacteria,2JI8I@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM O-Antigen	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TLS2_k127_5991119_3	629773.AORY01000002_gene1448	1.115e-36	154.0	COG1216@1|root,COG1216@2|Bacteria,1RM37@1224|Proteobacteria	1224|Proteobacteria	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5991119_1	1096930.L284_11700	3.436e-39	159.0	COG1216@1|root,COG1216@2|Bacteria,1N72Z@1224|Proteobacteria,2U5XZ@28211|Alphaproteobacteria,2K5BP@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyltransferase like family 2	-	-	-	ko:K16555	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	-	Glycos_transf_2
TLS2_k127_5991119_5	1121106.JQKB01000036_gene725	2.343e-26	124.0	COG0367@1|root,COG0367@2|Bacteria,1NNHE@1224|Proteobacteria	1224|Proteobacteria	E	asparagine synthase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5991119_2	1317118.ATO8_08391	7.276e-38	147.0	COG0707@1|root,COG0707@2|Bacteria,1RJH9@1224|Proteobacteria,2UCZ1@28211|Alphaproteobacteria,4KNWU@93682|Roseivivax	28211|Alphaproteobacteria	M	Oligosaccharide biosynthesis protein Alg14 like	pssD	-	-	-	-	-	-	-	-	-	-	-	Alg14
TLS2_k127_5991119_4	1396141.BATP01000037_gene3528	4.826e-34	140.0	COG5017@1|root,COG5017@2|Bacteria,46XGH@74201|Verrucomicrobia,2IVUQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
TLS2_k127_5991119_0	1479239.JQMU01000001_gene1993	4.301e-44	166.0	COG0500@1|root,COG2226@2|Bacteria,1RF1C@1224|Proteobacteria,2U86S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_5992685_0	1550091.JROE01000002_gene1131	2.613e-38	160.0	COG2312@1|root,COG2312@2|Bacteria,4NW00@976|Bacteroidetes,1ITY5@117747|Sphingobacteriia	976|Bacteroidetes	S	Erythromycin esterase	-	-	-	ko:K06880	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	CarbopepD_reg_2,Erythro_esteras
TLS2_k127_5992685_1	1280944.HY17_18820	2.673e-10	68.0	2DR6B@1|root,33ACQ@2|Bacteria,1NI4T@1224|Proteobacteria,2UKEW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5992685_2	682795.AciX8_3247	1.698e-06	59.0	COG5616@1|root,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TPR_8,TolB_N,Trans_reg_C
TLS2_k127_6016185_3	234267.Acid_5626	1.928e-24	115.0	COG5549@1|root,COG5549@2|Bacteria	234267.Acid_5626|-	O	protein import	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6016185_1	234267.Acid_6537	1.671e-198	635.0	COG1073@1|root,COG1073@2|Bacteria,3Y6M5@57723|Acidobacteria	57723|Acidobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6016185_0	1267535.KB906767_gene2241	1.352e-210	663.0	COG0621@1|root,COG0621@2|Bacteria,3Y2GT@57723|Acidobacteria,2JIEP@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TLS2_k127_6016185_2	234267.Acid_6705	8.263e-81	274.0	COG1259@1|root,COG1259@2|Bacteria,3Y4QD@57723|Acidobacteria	57723|Acidobacteria	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
TLS2_k127_6018082_3	234267.Acid_3882	1.152e-96	326.0	COG1028@1|root,COG1028@2|Bacteria,3Y3CD@57723|Acidobacteria	57723|Acidobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_6018082_2	1499967.BAYZ01000057_gene4681	8.746e-123	407.0	COG1397@1|root,COG1397@2|Bacteria,2NPWB@2323|unclassified Bacteria	2|Bacteria	O	ADP-ribosylglycohydrolase	draG	-	3.2.2.24	ko:K05521	-	-	-	-	ko00000,ko01000	-	-	-	ADP_ribosyl_GH
TLS2_k127_6018082_0	1267535.KB906767_gene844	1.381e-183	586.0	COG0260@1|root,COG0260@2|Bacteria,3Y33T@57723|Acidobacteria,2JHUM@204432|Acidobacteriia	204432|Acidobacteriia	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS2_k127_6018082_4	1267535.KB906767_gene845	1.482e-56	202.0	COG0691@1|root,COG0691@2|Bacteria,3Y4CC@57723|Acidobacteria,2JJ48@204432|Acidobacteriia	204432|Acidobacteriia	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
TLS2_k127_6018082_1	234267.Acid_1060	1.685e-181	588.0	COG0457@1|root,COG4796@1|root,COG0457@2|Bacteria,COG4796@2|Bacteria,3Y2G2@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the GSP D family	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Cohesin,Secretin,Secretin_N,TPR_8
TLS2_k127_6021965_0	1340493.JNIF01000003_gene4691	6.141e-169	545.0	COG0436@1|root,COG0436@2|Bacteria,3Y2TF@57723|Acidobacteria	57723|Acidobacteria	E	PFAM aminotransferase, class I	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_6021965_1	1267535.KB906767_gene5504	1.463e-114	376.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_6021965_2	234267.Acid_6539	6.051e-67	236.0	COG2930@1|root,COG2930@2|Bacteria,3Y2F0@57723|Acidobacteria	57723|Acidobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
TLS2_k127_6034247_1	1267535.KB906767_gene1910	9.675e-27	115.0	COG4566@1|root,COG4566@2|Bacteria,3Y58V@57723|Acidobacteria,2JJQJ@204432|Acidobacteriia	204432|Acidobacteriia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_6034247_0	204669.Acid345_3712	8.871e-242	766.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y3JK@57723|Acidobacteria,2JIZX@204432|Acidobacteriia	2|Bacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	cckA	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,GAF_3,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,dCache_1
TLS2_k127_6035983_0	713586.KB900536_gene2659	7.561e-55	197.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3
TLS2_k127_6035983_2	1449350.OCH239_09135	7.241e-15	79.0	2DE6P@1|root,2ZKQP@2|Bacteria,1P6Y4@1224|Proteobacteria,2UYER@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6035983_1	570952.ATVH01000014_gene2239	1.883e-40	159.0	COG2442@1|root,COG2442@2|Bacteria,1RIWP@1224|Proteobacteria,2U9YN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433,MerR_1
TLS2_k127_6044716_2	234267.Acid_6875	2.867e-44	168.0	COG3485@1|root,COG3485@2|Bacteria,3Y3FU@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_6044716_0	234267.Acid_6903	1.122e-69	239.0	COG3193@1|root,COG3193@2|Bacteria,3Y4PS@57723|Acidobacteria	57723|Acidobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
TLS2_k127_6044716_1	1121035.AUCH01000022_gene3191	1.526e-49	181.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2VK7T@28216|Betaproteobacteria,2KUKS@206389|Rhodocyclales	206389|Rhodocyclales	IQ	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase
TLS2_k127_6061329_0	471854.Dfer_5020	8.899e-75	257.0	COG4099@1|root,COG4099@2|Bacteria,4NKWC@976|Bacteroidetes,47N5A@768503|Cytophagia	976|Bacteroidetes	S	Phospholipase/Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Peptidase_S9
TLS2_k127_6061329_1	1267535.KB906767_gene4948	9.423e-73	256.0	COG0329@1|root,COG0329@2|Bacteria,3Y7V6@57723|Acidobacteria	57723|Acidobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_6061329_2	234267.Acid_0023	4.018e-36	143.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C,TAT_signal
TLS2_k127_6070659_5	383372.Rcas_2687	3.479e-11	70.0	297H5@1|root,2ZUQE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6070659_0	234267.Acid_6567	0.0	1101.0	COG0826@1|root,COG0826@2|Bacteria,3Y7M5@57723|Acidobacteria	57723|Acidobacteria	O	Collagenase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
TLS2_k127_6070659_4	1461694.ATO9_08475	4.452e-14	81.0	COG0494@1|root,COG0494@2|Bacteria,1MZB8@1224|Proteobacteria,2UDKJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS2_k127_6070659_2	1121015.N789_12835	7.23e-72	253.0	COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,1RYXR@1236|Gammaproteobacteria,1XA88@135614|Xanthomonadales	135614|Xanthomonadales	S	glyoxalase bleomycin resistance protein	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_6070659_1	1173027.Mic7113_4974	1.937e-197	628.0	COG3540@1|root,COG3540@2|Bacteria,1GJ0U@1117|Cyanobacteria,1HGHC@1150|Oscillatoriales	1117|Cyanobacteria	P	Alkaline phosphatase	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD_N
TLS2_k127_6070659_3	1340493.JNIF01000003_gene4059	1.503e-36	149.0	2C730@1|root,33CNG@2|Bacteria,3Y5XE@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6072651_0	365044.Pnap_1203	8.311e-162	535.0	COG4249@1|root,COG4249@2|Bacteria,1QWF7@1224|Proteobacteria,2WHK2@28216|Betaproteobacteria,4AJYX@80864|Comamonadaceae	28216|Betaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,Peptidase_C14
TLS2_k127_6076436_1	314230.DSM3645_10642	3.889e-130	427.0	COG1070@1|root,COG1070@2|Bacteria,2IXYW@203682|Planctomycetes	203682|Planctomycetes	G	COG1070 Sugar (pentulose and hexulose)	-	-	2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
TLS2_k127_6076436_0	518766.Rmar_0690	7.814e-153	497.0	COG1457@1|root,COG1457@2|Bacteria,4NHHC@976|Bacteroidetes	976|Bacteroidetes	F	Belongs to the purine-cytosine permease (2.A.39) family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6106436_0	697281.Mahau_2746	1.056e-178	572.0	COG5520@1|root,COG5520@2|Bacteria	2|Bacteria	M	Belongs to the glycosyl hydrolase 30 family	-	-	3.2.1.136,3.2.1.55,3.2.1.8	ko:K01181,ko:K15921,ko:K15924	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	CBM6,GH43,GH5	-	Beta_helix,Binary_toxB_2,Binary_toxB_3,CBM_6,CW_binding_1,Dockerin_1,Glyco_hydro_10,Glyco_hydro_30,Glyco_hydro_30C,Glyco_hydro_43,Lipase_GDSL_2,RicinB_lectin_2,Ricin_B_lectin
TLS2_k127_6106436_2	742726.HMPREF9448_02737	2.032e-128	427.0	COG1397@1|root,COG1397@2|Bacteria,4NG36@976|Bacteroidetes,2FNB7@200643|Bacteroidia,22X71@171551|Porphyromonadaceae	976|Bacteroidetes	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
TLS2_k127_6106436_1	1267535.KB906767_gene2292	9.626e-138	446.0	COG1132@1|root,COG1132@2|Bacteria,3Y2ZR@57723|Acidobacteria,2JHJA@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter, transmembrane	-	-	-	ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
TLS2_k127_6107142_0	1121403.AUCV01000029_gene2732	5.664e-205	669.0	COG4644@1|root,COG4644@2|Bacteria,1MUIU@1224|Proteobacteria,42YHN@68525|delta/epsilon subdivisions,2WTYP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase Tn3 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_Tn3,DUF4158
TLS2_k127_611499_0	234267.Acid_1224	1.424e-68	251.0	COG5549@1|root,COG5549@2|Bacteria	2|Bacteria	O	protein import	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,Peptidase_M10
TLS2_k127_611499_1	234267.Acid_1406	1.766e-36	149.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02479,ko:K07684,ko:K07685	ko02020,map02020	M00471,M00472	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
TLS2_k127_6126926_4	1267535.KB906767_gene4616	6.061e-34	133.0	COG1923@1|root,COG1923@2|Bacteria,3Y59T@57723|Acidobacteria	57723|Acidobacteria	S	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
TLS2_k127_6126926_0	1267535.KB906767_gene4617	4.883e-152	492.0	COG2262@1|root,COG2262@2|Bacteria,3Y2FK@57723|Acidobacteria,2JI0F@204432|Acidobacteriia	204432|Acidobacteriia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TLS2_k127_6126926_3	234267.Acid_6304	4.318e-74	261.0	COG0558@1|root,COG0558@2|Bacteria,3Y520@57723|Acidobacteria	57723|Acidobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_6126926_1	1303518.CCALI_00300	9.296e-87	301.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	rip3	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K06212,ko:K06402	-	-	-	-	ko00000,ko01000,ko01002,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	CBS,Form_Nir_trans,Peptidase_M50
TLS2_k127_6126926_2	240016.ABIZ01000001_gene1147	1.578e-80	278.0	COG1225@1|root,COG1225@2|Bacteria,46WXF@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA_2
TLS2_k127_6126926_5	234267.Acid_5000	2.139e-09	63.0	COG1680@1|root,COG1680@2|Bacteria,3Y85K@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_6128350_2	234267.Acid_3731	3.885e-10	65.0	2EXAB@1|root,33QKZ@2|Bacteria,3Y6WS@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6128350_0	1340493.JNIF01000003_gene4022	0.0	1043.0	COG0531@1|root,COG0531@2|Bacteria,3Y2RG@57723|Acidobacteria	57723|Acidobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
TLS2_k127_6128350_1	1267535.KB906767_gene108	1.201e-152	492.0	COG0617@1|root,COG0617@2|Bacteria,3Y3B8@57723|Acidobacteria,2JIIS@204432|Acidobacteriia	204432|Acidobacteriia	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
TLS2_k127_6130831_0	903818.KI912268_gene2971	1.476e-55	211.0	COG0457@1|root,COG0457@2|Bacteria	903818.KI912268_gene2971|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6130831_1	1125863.JAFN01000001_gene877	0.0002084	52.0	COG0457@1|root,COG0457@2|Bacteria	1125863.JAFN01000001_gene877|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6132259_1	234267.Acid_5120	2.142e-188	590.0	COG0050@1|root,COG0050@2|Bacteria,3Y2JG@57723|Acidobacteria	57723|Acidobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TLS2_k127_6132259_0	1267535.KB906767_gene2707	0.0	1172.0	COG0480@1|root,COG0480@2|Bacteria,3Y2YX@57723|Acidobacteria,2JIQP@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_6132259_2	1267535.KB906767_gene2708	2.137e-77	261.0	COG0049@1|root,COG0049@2|Bacteria,3Y3FF@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
TLS2_k127_6132259_3	234267.Acid_5123	1.352e-71	243.0	COG0048@1|root,COG0048@2|Bacteria,3Y4JQ@57723|Acidobacteria	57723|Acidobacteria	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
TLS2_k127_6132259_5	63577.G9NQU0	0.0005491	44.0	COG2162@1|root,2S76B@2759|Eukaryota,3A9WT@33154|Opisthokonta,3P7XY@4751|Fungi,3RJH5@4890|Ascomycota,21Q91@147550|Sordariomycetes,3TI1G@5125|Hypocreales,3U0QH@5129|Hypocreaceae	4751|Fungi	H	Belongs to the arylamine N-acetyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_2
TLS2_k127_6132259_4	1235790.C805_02376	6.939e-12	76.0	COG0457@1|root,COG0457@2|Bacteria,1V5Z6@1239|Firmicutes,24GM8@186801|Clostridia,25Y9M@186806|Eubacteriaceae	186801|Clostridia	K	PPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_22,DUF4062,NB-ARC,TPR_10,TPR_12,TPR_7,TPR_8
TLS2_k127_6136261_0	234267.Acid_7155	2.221e-61	215.0	COG2264@1|root,COG2264@2|Bacteria,3Y3UA@57723|Acidobacteria	57723|Acidobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS2_k127_6136261_1	234267.Acid_5387	8.039e-53	206.0	COG3119@1|root,COG3119@2|Bacteria,3Y5BN@57723|Acidobacteria	57723|Acidobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_6136585_1	1403819.BATR01000130_gene4642	2.658e-22	102.0	2EK8J@1|root,33DYX@2|Bacteria,46VTQ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6136585_0	234267.Acid_1640	2.017e-299	935.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS2_k127_6137091_0	1340493.JNIF01000003_gene4575	9.007e-208	676.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Laminin_G_3,PSCyt1,PSCyt2,PSD1
TLS2_k127_6137091_2	234267.Acid_0668	9.177e-63	227.0	COG1802@1|root,COG1802@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_6137091_4	1231392.OCGS_1989	6.11e-17	81.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,2TQMP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor	-	-	2.4.1.213	ko:K03692	-	-	-	-	ko00000,ko01000	-	GT20	-	Glyco_transf_20
TLS2_k127_6137091_3	1266908.AQPB01000056_gene2090	9.619e-20	95.0	COG5654@1|root,COG5654@2|Bacteria,1N6P3@1224|Proteobacteria,1S7EU@1236|Gammaproteobacteria,1WZID@135613|Chromatiales	135613|Chromatiales	S	RES	-	-	-	-	-	-	-	-	-	-	-	-	RES
TLS2_k127_6137091_1	756272.Plabr_0954	5.225e-84	285.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	DUF3701,Phage_int_SAM_1,Phage_integrase
TLS2_k127_6137525_12	1340493.JNIF01000003_gene2778	3.974e-24	106.0	COG1295@1|root,COG1295@2|Bacteria,3Y4P8@57723|Acidobacteria	57723|Acidobacteria	S	PFAM ribonuclease	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_6137525_3	234267.Acid_1515	9.14e-170	563.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6137525_2	234267.Acid_1514	1.107e-215	693.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6137525_7	1340493.JNIF01000003_gene2775	5.51e-125	404.0	COG1216@1|root,COG1216@2|Bacteria,3Y9AS@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_6137525_8	1340493.JNIF01000003_gene2774	1.493e-57	207.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_1,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31,TPR_2,TPR_8
TLS2_k127_6137525_6	234267.Acid_1863	3.32e-132	432.0	COG4956@1|root,COG4956@2|Bacteria,3Y2RT@57723|Acidobacteria	57723|Acidobacteria	S	Large family of predicted nucleotide-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
TLS2_k127_6137525_13	234267.Acid_0448	8.784e-19	93.0	COG2318@1|root,COG2318@2|Bacteria,3Y85M@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_6137525_14	1121012.AUKX01000042_gene2497	4.861e-12	68.0	2EAEB@1|root,334HW@2|Bacteria,4NVVS@976|Bacteroidetes,1I529@117743|Flavobacteriia,23HN0@178469|Arenibacter	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6137525_0	1286632.P278_17120	0.0	1148.0	COG0243@1|root,COG0243@2|Bacteria,4NG4N@976|Bacteroidetes,1HXQ0@117743|Flavobacteriia	976|Bacteroidetes	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TLS2_k127_6137525_10	143224.JQMD01000002_gene230	2.725e-47	179.0	28JYU@1|root,2Z9NZ@2|Bacteria,4NKTR@976|Bacteroidetes,1I0RC@117743|Flavobacteriia	976|Bacteroidetes	P	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_C7,Paired_CXXCH_1
TLS2_k127_6137525_5	1178825.ALIH01000002_gene932	8.168e-146	467.0	COG0437@1|root,COG0437@2|Bacteria,4NI8R@976|Bacteroidetes,1I01K@117743|Flavobacteriia	976|Bacteroidetes	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11
TLS2_k127_6137525_4	313603.FB2170_03735	3.049e-167	537.0	COG5557@1|root,COG5557@2|Bacteria,4NG2Z@976|Bacteroidetes,1I0YA@117743|Flavobacteriia	976|Bacteroidetes	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
TLS2_k127_6137525_11	232346.JHQL01000006_gene3105	7.999e-30	121.0	COG0599@1|root,COG0599@2|Bacteria,1N2ZQ@1224|Proteobacteria,1SBZC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_6137525_1	234267.Acid_5065	1.035e-255	799.0	COG1674@1|root,COG1674@2|Bacteria,3Y3CJ@57723|Acidobacteria	57723|Acidobacteria	D	PFAM cell divisionFtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TLS2_k127_6142240_3	1123253.AUBD01000008_gene576	4.419e-78	271.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1RYFT@1236|Gammaproteobacteria,1X97Z@135614|Xanthomonadales	135614|Xanthomonadales	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_6142240_4	1267535.KB906767_gene781	2.536e-67	245.0	COG0457@1|root,COG0457@2|Bacteria,3Y7TN@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6142240_1	234267.Acid_7136	1.164e-158	511.0	COG0743@1|root,COG0743@2|Bacteria,3Y30J@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
TLS2_k127_6142240_0	234267.Acid_7135	5.404e-166	532.0	COG0750@1|root,COG0750@2|Bacteria,3Y2KN@57723|Acidobacteria	57723|Acidobacteria	M	zinc metalloprotease	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
TLS2_k127_6142240_5	1267535.KB906767_gene3788	2.372e-62	221.0	COG0782@1|root,COG0782@2|Bacteria,3Y49X@57723|Acidobacteria,2JJ1A@204432|Acidobacteriia	204432|Acidobacteriia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TLS2_k127_6142240_2	1267535.KB906767_gene3789	1.058e-84	289.0	COG0558@1|root,COG0558@2|Bacteria,3Y427@57723|Acidobacteria,2JID7@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_6142367_1	1340493.JNIF01000004_gene919	1.007e-110	366.0	COG2960@1|root,COG2960@2|Bacteria	2|Bacteria	M	long-chain fatty acid transporting porin activity	-	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	HXXSHH
TLS2_k127_6142367_0	234267.Acid_5827	0.0	1090.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5,zf-C4_Topoisom
TLS2_k127_6142367_2	401053.AciPR4_0804	7.855e-47	170.0	COG1274@1|root,COG1274@2|Bacteria,3Y2IH@57723|Acidobacteria,2JIZH@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
TLS2_k127_6143567_1	1340493.JNIF01000003_gene3853	4.377e-93	310.0	COG0583@1|root,COG0583@2|Bacteria,3Y4EH@57723|Acidobacteria	57723|Acidobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_6143567_0	1267535.KB906767_gene4768	1.627e-159	516.0	2DBP2@1|root,2ZA71@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6143567_2	234267.Acid_0822	1.867e-63	224.0	COG1524@1|root,COG1524@2|Bacteria,3Y4MJ@57723|Acidobacteria	57723|Acidobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_6143577_4	1340493.JNIF01000003_gene2489	7.966e-56	199.0	COG3191@1|root,COG3191@2|Bacteria	2|Bacteria	EQ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
TLS2_k127_6143577_1	234267.Acid_0582	9.628e-109	366.0	COG0767@1|root,COG0767@2|Bacteria,3Y43S@57723|Acidobacteria	57723|Acidobacteria	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
TLS2_k127_6143577_3	234267.Acid_0581	1.974e-93	320.0	COG1127@1|root,COG1127@2|Bacteria,3Y3YI@57723|Acidobacteria	57723|Acidobacteria	Q	PFAM ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TLS2_k127_6143577_0	1267535.KB906767_gene3564	5.707e-112	372.0	COG1463@1|root,COG1463@2|Bacteria,3Y3SX@57723|Acidobacteria,2JIP6@204432|Acidobacteriia	204432|Acidobacteriia	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
TLS2_k127_6143577_2	234267.Acid_0579	3.67e-99	330.0	COG3394@1|root,COG3394@2|Bacteria,3Y441@57723|Acidobacteria	57723|Acidobacteria	G	PFAM YdjC family protein	-	-	-	-	-	-	-	-	-	-	-	-	YdjC
TLS2_k127_614939_2	640513.Entas_1073	1.93e-38	151.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,1RMCH@1236|Gammaproteobacteria,3X3NQ@547|Enterobacter	1236|Gammaproteobacteria	P	ATPases associated with a variety of cellular activities	rbsA_1	-	3.6.3.17	ko:K02056,ko:K10441,ko:K10542,ko:K10545,ko:K10551,ko:K10562,ko:K17204,ko:K17210	ko02010,map02010	M00212,M00214,M00215,M00217,M00220,M00221,M00590,M00592	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.11,3.A.1.2.13,3.A.1.2.16,3.A.1.2.19,3.A.1.2.21,3.A.1.2.3,3.A.1.2.4,3.A.1.2.6,3.A.1.2.9	-	-	ABC_tran
TLS2_k127_614939_3	632518.Calow_0314	1.552e-27	120.0	COG5618@1|root,COG5618@2|Bacteria,1V221@1239|Firmicutes,24G1Q@186801|Clostridia	186801|Clostridia	S	Predicted periplasmic lipoprotein (DUF2291)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2291
TLS2_k127_614939_1	1382306.JNIM01000001_gene2806	2.572e-108	364.0	COG2390@1|root,COG2390@2|Bacteria,2G8CS@200795|Chloroflexi	200795|Chloroflexi	K	Putative sugar-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r4,Sugar-bind
TLS2_k127_614939_0	1382306.JNIM01000001_gene2807	6.319e-134	436.0	COG0554@1|root,COG0554@2|Bacteria,2G5TV@200795|Chloroflexi	2|Bacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK3	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS2_k127_6149916_0	1192034.CAP_9004	6.565e-78	279.0	COG5297@1|root,COG5297@2|Bacteria,1PG5N@1224|Proteobacteria,439EZ@68525|delta/epsilon subdivisions,2X4Q8@28221|Deltaproteobacteria,2YZDX@29|Myxococcales	28221|Deltaproteobacteria	G	CBD_II	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,PSCyt3,PSD2,PSD3,PSD4,PSD5
TLS2_k127_6149916_1	886293.Sinac_7120	4.201e-48	178.0	COG3386@1|root,COG3386@2|Bacteria,2IXCR@203682|Planctomycetes	203682|Planctomycetes	G	SMP-30/Gluconolaconase/LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
TLS2_k127_6157821_0	1267535.KB906767_gene3693	2.131e-166	537.0	COG0248@1|root,COG0248@2|Bacteria,3Y3H5@57723|Acidobacteria,2JIDG@204432|Acidobacteriia	204432|Acidobacteriia	FP	PFAM Ppx GppA phosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
TLS2_k127_6157821_6	1267535.KB906767_gene3692	1.071e-06	58.0	COG5607@1|root,COG5607@2|Bacteria	2|Bacteria	F	PFAM CHAD domain containing protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
TLS2_k127_6157821_7	1380390.JIAT01000001_gene5042	1.47e-05	54.0	COG5607@1|root,COG5607@2|Bacteria,2HP53@201174|Actinobacteria,4CQGX@84995|Rubrobacteria	84995|Rubrobacteria	S	CHAD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
TLS2_k127_6157821_4	1095769.CAHF01000022_gene293	4.58e-41	174.0	COG2602@1|root,COG2602@2|Bacteria,1NWXE@1224|Proteobacteria,2VS75@28216|Betaproteobacteria	28216|Betaproteobacteria	M	beta-lactamase	bla	-	3.5.2.6	ko:K17838,ko:K19211,ko:K21277	ko01501,map01501	-	R06363	RC01499	br01600,ko00000,ko00001,ko01000,ko01504	-	-	-	Transpeptidase
TLS2_k127_6157821_1	234267.Acid_4466	5.534e-69	261.0	COG2367@1|root,COG2367@2|Bacteria,3Y3UF@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
TLS2_k127_6157821_2	234267.Acid_0995	5.134e-62	239.0	COG3391@1|root,COG3391@2|Bacteria,3Y7I2@57723|Acidobacteria	57723|Acidobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6157821_3	1134474.O59_000985	3.78e-54	200.0	COG2503@1|root,COG2503@2|Bacteria,1RB4N@1224|Proteobacteria,1SB1V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Acid phosphatase	lppC	-	-	-	-	-	-	-	-	-	-	-	Acid_phosphat_B
TLS2_k127_6157821_5	234267.Acid_3540	4.422e-32	128.0	29ITM@1|root,305QZ@2|Bacteria,3Y4F3@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6162196_1	1380355.JNIJ01000019_gene4585	1.228e-200	639.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2U1QY@28211|Alphaproteobacteria,3JRK4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TLS2_k127_6162196_0	234267.Acid_7146	1.154e-247	780.0	COG1916@1|root,COG1916@2|Bacteria,3Y6KT@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6162196_2	234267.Acid_7147	2.851e-122	395.0	COG0714@1|root,COG0714@2|Bacteria,3Y6Z3@57723|Acidobacteria	57723|Acidobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
TLS2_k127_6173144_1	234267.Acid_1132	4.801e-53	201.0	COG2972@1|root,COG2972@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
TLS2_k127_6173144_0	234267.Acid_6775	0.0	1456.0	COG1629@1|root,COG4771@2|Bacteria,3Y3KD@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_6173144_2	234267.Acid_2985	6.946e-12	72.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_6174125_0	1340493.JNIF01000003_gene2812	1.57e-214	694.0	COG3459@1|root,COG3459@2|Bacteria,3Y3E9@57723|Acidobacteria	57723|Acidobacteria	G	Putative glucoamylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
TLS2_k127_6185289_1	1219035.NT2_02_01020	6.174e-83	284.0	COG1988@1|root,COG1988@2|Bacteria,1RA9E@1224|Proteobacteria,2U5TK@28211|Alphaproteobacteria,2K3A3@204457|Sphingomonadales	204457|Sphingomonadales	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
TLS2_k127_6185289_3	1123267.JONN01000001_gene906	7.115e-67	240.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria,2K1IB@204457|Sphingomonadales	204457|Sphingomonadales	M	synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS2_k127_6185289_7	861299.J421_0074	1.006e-15	81.0	COG0708@1|root,COG0708@2|Bacteria	2|Bacteria	L	double-stranded DNA 3'-5' exodeoxyribonuclease activity	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
TLS2_k127_6185289_4	1282360.ABAC460_00730	4.186e-38	145.0	COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,2U9M1@28211|Alphaproteobacteria,2KH4T@204458|Caulobacterales	204458|Caulobacterales	S	Putative member of DMT superfamily (DUF486)	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
TLS2_k127_6185289_6	368407.Memar_0392	4.944e-33	136.0	arCOG08007@1|root,arCOG08007@2157|Archaea,2Y5WI@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6185289_0	401053.AciPR4_3043	5.898e-112	374.0	COG2355@1|root,COG2355@2|Bacteria,3Y39A@57723|Acidobacteria,2JI1H@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Peptidase M19, renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
TLS2_k127_6185289_2	1267535.KB906767_gene457	3.161e-82	287.0	COG0457@1|root,COG0457@2|Bacteria,3Y7U6@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6189046_4	234267.Acid_6449	4.523e-21	98.0	COG2510@1|root,COG2510@2|Bacteria,3Y549@57723|Acidobacteria	57723|Acidobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	EamA,TMEM234
TLS2_k127_6189046_3	1340493.JNIF01000003_gene2524	1.185e-23	104.0	COG2510@1|root,COG2510@2|Bacteria	2|Bacteria	EG	membrane	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
TLS2_k127_6189046_0	234267.Acid_7504	1.732e-273	845.0	COG1032@1|root,COG1032@2|Bacteria,3Y2QU@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnJ	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
TLS2_k127_6189046_1	1340493.JNIF01000003_gene2805	1.274e-60	216.0	COG1607@1|root,COG1607@2|Bacteria,3Y53T@57723|Acidobacteria	57723|Acidobacteria	I	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_6189046_6	1267535.KB906767_gene2337	2.435e-05	51.0	295WJ@1|root,2ZT7G@2|Bacteria,3Y8RM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6189046_2	234267.Acid_0135	1.125e-34	137.0	COG0457@1|root,COG0457@2|Bacteria,3Y99M@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6189046_5	234267.Acid_7046	5.568e-20	89.0	2FF7H@1|root,3475G@2|Bacteria,3Y8K8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_619142_12	63737.Npun_F3172	1.08e-11	65.0	COG0300@1|root,COG3321@1|root,COG0300@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1HIST@1161|Nostocales	1117|Cyanobacteria	Q	acyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N_2,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
TLS2_k127_619142_2	497964.CfE428DRAFT_1845	4.746e-105	368.0	COG4585@1|root,COG4585@2|Bacteria,46SGT@74201|Verrucomicrobia	2|Bacteria	T	histidine kinase dimerisation and phosphoacceptor region	-	-	2.7.13.3	ko:K11617	ko02020,map02020	M00481,M00754	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF1080,HAMP,HATPase_c,HisKA_3
TLS2_k127_619142_6	234267.Acid_3730	1.91e-66	239.0	COG2304@1|root,COG2304@2|Bacteria,3Y6RY@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_619142_1	234267.Acid_7054	3.178e-112	370.0	COG0077@1|root,COG0077@2|Bacteria,3Y49H@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
TLS2_k127_619142_4	234267.Acid_7053	7.441e-73	255.0	COG0163@1|root,COG0163@2|Bacteria,3Y2S8@57723|Acidobacteria	57723|Acidobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	-	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
TLS2_k127_619142_3	1340493.JNIF01000003_gene4277	1.453e-78	271.0	COG1396@1|root,COG1396@2|Bacteria,3Y5UK@57723|Acidobacteria	57723|Acidobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_619142_9	1267535.KB906767_gene4829	1.12e-22	109.0	2FHXP@1|root,349QN@2|Bacteria,3Y8M3@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_619142_11	234267.Acid_7051	2.138e-12	76.0	2DEME@1|root,2ZNG1@2|Bacteria,3Y8YM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_619142_10	1267535.KB906767_gene4833	2.464e-20	98.0	290IJ@1|root,2ZN7C@2|Bacteria,3Y95B@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_619142_5	1347342.BN863_18240	2.329e-71	261.0	COG2730@1|root,COG2730@2|Bacteria,4PKHG@976|Bacteroidetes,1I0J9@117743|Flavobacteriia	976|Bacteroidetes	G	Protein of unknown function (DUF4038)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
TLS2_k127_619142_8	658655.HMPREF0988_02475	6.146e-28	126.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1TSRS@1239|Firmicutes,24BXX@186801|Clostridia,27MBR@186928|unclassified Lachnospiraceae	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18,HTH_AraC
TLS2_k127_619142_0	1340493.JNIF01000004_gene88	0.0	1079.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_619142_7	595460.RRSWK_00730	5.179e-56	205.0	COG2730@1|root,COG2730@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_1,Cellulase,Collagen_bind_2,DUF4038,DUF5060
TLS2_k127_61935_2	234267.Acid_5399	1.755e-17	94.0	2E1AY@1|root,32WQW@2|Bacteria,3Y8WG@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_61935_3	234267.Acid_6507	1.101e-09	64.0	COG2834@1|root,COG2834@2|Bacteria,3Y51N@57723|Acidobacteria	57723|Acidobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	LolA,LolA_like
TLS2_k127_6193913_1	319003.Bra1253DRAFT_01223	2.172e-32	132.0	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2TU2C@28211|Alphaproteobacteria,3K0F4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Dioxygenase	-	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,PCDO_beta_N
TLS2_k127_6193913_3	1403819.BATR01000094_gene2920	5.179e-22	100.0	COG0346@1|root,COG0346@2|Bacteria,46XKV@74201|Verrucomicrobia,2IW5M@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_6193913_0	46429.BV95_03551	1.425e-74	259.0	COG0500@1|root,COG0500@2|Bacteria,1QV66@1224|Proteobacteria,2TWBB@28211|Alphaproteobacteria,2KEE1@204457|Sphingomonadales	204457|Sphingomonadales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_6195890_2	756272.Plabr_3328	7.483e-31	130.0	COG5492@1|root,COG5492@2|Bacteria,2IXP9@203682|Planctomycetes	203682|Planctomycetes	N	Protein of unknown function (DUF1549)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt2,PSD1
TLS2_k127_6195890_1	1210884.HG799463_gene10098	7.983e-33	147.0	COG3064@1|root,COG3064@2|Bacteria,2IX90@203682|Planctomycetes	203682|Planctomycetes	M	Bacterial pre-peptidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	PPC
TLS2_k127_6195890_0	234267.Acid_7589	2.572e-86	310.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_7589|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_619842_4	861299.J421_6141	2.34e-24	109.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6141|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_619842_1	1267535.KB906767_gene3864	8.875e-127	421.0	COG2807@1|root,COG2807@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_619842_2	234267.Acid_0442	7.253e-38	144.0	COG2128@1|root,COG2128@2|Bacteria,3Y8AP@57723|Acidobacteria	57723|Acidobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_619842_3	861299.J421_5853	6.582e-36	137.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_619842_0	1267535.KB906767_gene3865	0.0	1118.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_619880_0	1340493.JNIF01000003_gene1351	5.244e-60	216.0	COG1413@1|root,COG1413@2|Bacteria,3Y4Z5@57723|Acidobacteria	57723|Acidobacteria	C	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
TLS2_k127_619880_1	1267533.KB906734_gene4381	8.528e-35	144.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_6200113_3	926560.KE387025_gene4070	1.743e-45	167.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061,ko:K07100	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TLS2_k127_6200113_1	1144275.COCOR_00597	1.143e-75	259.0	COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,439ZV@68525|delta/epsilon subdivisions,2X2Y1@28221|Deltaproteobacteria,2YWXH@29|Myxococcales	28221|Deltaproteobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
TLS2_k127_6200113_2	391624.OIHEL45_16561	7.781e-66	233.0	COG3861@1|root,COG3861@2|Bacteria,1RD6Y@1224|Proteobacteria,2U683@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	PRC
TLS2_k127_6200113_0	1340493.JNIF01000003_gene2499	0.0	1274.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6204408_1	639030.JHVA01000001_gene1901	2.531e-49	188.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_6204408_0	1054213.HMPREF9946_03603	3.252e-99	334.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TSXM@28211|Alphaproteobacteria,2JV66@204441|Rhodospirillales	204441|Rhodospirillales	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Iso_dh
TLS2_k127_6208964_5	106370.Francci3_2450	7.264e-06	52.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4ERC2@85013|Frankiales	201174|Actinobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_11,Methyltransf_12,Methyltransf_25,PP-binding,Thioesterase
TLS2_k127_6208964_2	56110.Oscil6304_3459	3.804e-36	146.0	COG2091@1|root,COG2091@2|Bacteria,1G5GA@1117|Cyanobacteria,1HAPE@1150|Oscillatoriales	1117|Cyanobacteria	H	Belongs to the P-Pant transferase superfamily	hetI	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_6208964_3	278963.ATWD01000001_gene4139	4.63e-36	139.0	COG3093@1|root,COG3093@2|Bacteria,3Y5GT@57723|Acidobacteria,2JJW9@204432|Acidobacteriia	204432|Acidobacteriia	K	addiction module antidote protein, HigA family	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
TLS2_k127_6208964_4	278963.ATWD01000001_gene4140	2.803e-30	123.0	COG3549@1|root,COG3549@2|Bacteria,3Y5SB@57723|Acidobacteria,2JK0A@204432|Acidobacteriia	204432|Acidobacteriia	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
TLS2_k127_6208964_1	1519464.HY22_06795	9.227e-48	179.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_6208964_0	1356852.N008_05325	3.026e-58	213.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,4NK8Q@976|Bacteroidetes,47KVN@768503|Cytophagia	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
TLS2_k127_621081_2	743719.PaelaDRAFT_1372	1.83e-21	99.0	COG3119@1|root,COG3119@2|Bacteria,1V6NF@1239|Firmicutes,4HKTS@91061|Bacilli,26V7Z@186822|Paenibacillaceae	91061|Bacilli	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_621081_0	344747.PM8797T_11189	1.797e-136	446.0	COG5434@1|root,COG5434@2|Bacteria,2IX4E@203682|Planctomycetes	203682|Planctomycetes	M	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,Pectate_lyase_3
TLS2_k127_621081_1	234267.Acid_1934	1.758e-111	378.0	COG1629@1|root,COG4771@2|Bacteria,3Y6GR@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6211867_4	1121904.ARBP01000018_gene2704	7.929e-14	75.0	COG4409@1|root,COG4409@2|Bacteria,4NIJX@976|Bacteroidetes,47MH2@768503|Cytophagia	976|Bacteroidetes	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_6211867_0	234267.Acid_2658	6.199e-158	508.0	COG4409@1|root,COG4692@1|root,COG4409@2|Bacteria,COG4692@2|Bacteria	2|Bacteria	G	BNR repeat-like domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	BNR_2
TLS2_k127_6211867_1	1267535.KB906767_gene32	2.443e-132	438.0	COG0457@1|root,COG0457@2|Bacteria,3Y3WM@57723|Acidobacteria	57723|Acidobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS2_k127_6211867_5	1218084.BBJK01000165_gene7776	7.516e-12	77.0	COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,2VR7H@28216|Betaproteobacteria,1K1TE@119060|Burkholderiaceae	28216|Betaproteobacteria	M	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
TLS2_k127_6211867_2	686340.Metal_2156	2.287e-41	157.0	arCOG06832@1|root,31H39@2|Bacteria,1RJBH@1224|Proteobacteria,1SNXE@1236|Gammaproteobacteria,1XGIS@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6211867_3	935261.JAGL01000051_gene2931	1.809e-26	117.0	arCOG06832@1|root,31H39@2|Bacteria,1RJBH@1224|Proteobacteria,2U9PE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
TLS2_k127_621195_1	1267535.KB906767_gene4085	9.203e-131	424.0	COG1015@1|root,COG1015@2|Bacteria,3Y6GB@57723|Acidobacteria	57723|Acidobacteria	G	Metalloenzyme superfamily	-	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
TLS2_k127_621195_4	1267535.KB906767_gene4086	6.251e-88	305.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF2092,Redoxin
TLS2_k127_621195_5	234267.Acid_5949	5.508e-58	207.0	COG0817@1|root,COG0817@2|Bacteria,3Y5FH@57723|Acidobacteria	57723|Acidobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
TLS2_k127_621195_2	234267.Acid_5948	9.963e-108	354.0	COG0217@1|root,COG0217@2|Bacteria,3Y2UW@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TLS2_k127_621195_3	1156935.QWE_19483	4.362e-90	308.0	COG3386@1|root,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,2TSXG@28211|Alphaproteobacteria,4B993@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	gluconolactonase	-	GO:0003674,GO:0003824,GO:0004341,GO:0016787,GO:0016788,GO:0052689	3.1.1.17	ko:K01053,ko:K14274	ko00030,ko00040,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00040,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02427,R02933,R03751	RC00537,RC00713,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
TLS2_k127_621195_0	886293.Sinac_6485	3.845e-280	878.0	COG0613@1|root,COG0613@2|Bacteria,2IY27@203682|Planctomycetes	203682|Planctomycetes	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_621195_7	448385.sce0716	2.852e-14	78.0	COG0520@1|root,COG0520@2|Bacteria,1R4SM@1224|Proteobacteria	1224|Proteobacteria	M	Class V aminotransferase	-	-	5.1.1.17	ko:K04127	ko00311,ko01100,ko01130,map00311,map01100,map01130	M00673	R04147	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
TLS2_k127_621812_3	234267.Acid_0769	1.374e-159	509.0	COG1111@1|root,COG1205@1|root,COG1111@2|Bacteria,COG1205@2|Bacteria,3Y61D@57723|Acidobacteria	57723|Acidobacteria	L	Domain of unknown function (DUF1998)	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
TLS2_k127_621812_4	1267535.KB906767_gene3257	1.879e-146	471.0	COG0836@1|root,COG0836@2|Bacteria,3Y2W2@57723|Acidobacteria,2JI4D@204432|Acidobacteriia	204432|Acidobacteriia	M	mannose-6-phosphate isomerase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
TLS2_k127_621812_6	1340493.JNIF01000003_gene3710	2.059e-92	310.0	COG0681@1|root,COG0681@2|Bacteria,3Y40D@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS2_k127_621812_5	1340493.JNIF01000003_gene3710	1.026e-111	368.0	COG0681@1|root,COG0681@2|Bacteria,3Y40D@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS2_k127_621812_2	1267535.KB906767_gene4235	6.488e-186	604.0	COG1506@1|root,COG1506@2|Bacteria,3Y6QI@57723|Acidobacteria	57723|Acidobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_621812_1	1340493.JNIF01000003_gene1331	3.505e-218	683.0	COG2873@1|root,COG2873@2|Bacteria,3Y2JU@57723|Acidobacteria	57723|Acidobacteria	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
TLS2_k127_621812_0	234267.Acid_2046	0.0	3081.0	COG0642@1|root,COG0745@1|root,COG1511@1|root,COG2770@1|root,COG3437@1|root,COG0745@2|Bacteria,COG1511@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,COG3437@2|Bacteria,3Y6RW@57723|Acidobacteria	57723|Acidobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg
TLS2_k127_6221446_0	1121438.JNJA01000023_gene373	1.27e-57	209.0	28P7U@1|root,2ZC21@2|Bacteria,1NTJA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6223019_1	1267535.KB906767_gene5471	1.812e-234	731.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,3Y2RE@57723|Acidobacteria,2JHM7@204432|Acidobacteriia	204432|Acidobacteriia	G	Maltogenic Amylase, C-terminal domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
TLS2_k127_6223019_0	1267535.KB906767_gene5055	2.496e-266	837.0	COG0366@1|root,COG0366@2|Bacteria,3Y2ZW@57723|Acidobacteria,2JICY@204432|Acidobacteriia	204432|Acidobacteriia	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
TLS2_k127_6223019_4	1121920.AUAU01000008_gene1654	3.131e-09	64.0	2EMZZ@1|root,33FN5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6223019_2	1267535.KB906767_gene182	1.253e-121	400.0	COG3214@1|root,COG3214@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS2_k127_6223019_3	344747.PM8797T_17407	9.848e-56	197.0	COG0673@1|root,COG0673@2|Bacteria,2IWTD@203682|Planctomycetes	203682|Planctomycetes	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_622767_1	339670.Bamb_0152	5.305e-39	154.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2VH3M@28216|Betaproteobacteria,1K03X@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_5,Glyco_transf_41,TPR_1,TPR_10,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
TLS2_k127_622767_0	234267.Acid_2017	1.196e-182	589.0	COG1506@1|root,COG1506@2|Bacteria,3Y2HK@57723|Acidobacteria	57723|Acidobacteria	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
TLS2_k127_6243903_3	401053.AciPR4_0185	3.869e-06	56.0	COG1629@1|root,COG4771@2|Bacteria,3Y2QR@57723|Acidobacteria,2JKBG@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_6243903_1	706587.Desti_1672	1.753e-46	171.0	COG0432@1|root,COG0432@2|Bacteria,1N5SN@1224|Proteobacteria,42SJC@68525|delta/epsilon subdivisions,2WP9F@28221|Deltaproteobacteria,2MRXI@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TLS2_k127_6243903_0	261292.Nit79A3_1686	1.917e-65	231.0	2EJ79@1|root,33CYD@2|Bacteria,1NNFN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6248294_1	1267535.KB906767_gene871	1.973e-74	253.0	COG1398@1|root,COG1398@2|Bacteria,3Y6GE@57723|Acidobacteria	57723|Acidobacteria	I	Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
TLS2_k127_6248294_0	1340493.JNIF01000003_gene3128	4.18e-100	346.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_6250080_4	234267.Acid_5374	3.095e-100	334.0	COG2201@1|root,COG2201@2|Bacteria,3Y35K@57723|Acidobacteria	57723|Acidobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
TLS2_k127_6250080_12	240015.ACP_0967	1.874e-10	69.0	2CEWK@1|root,33BBP@2|Bacteria,3Y5YV@57723|Acidobacteria,2JNQP@204432|Acidobacteriia	204432|Acidobacteriia	S	Chemotaxis phosphatase CheX	-	-	-	-	-	-	-	-	-	-	-	-	CheX
TLS2_k127_6250080_11	1340493.JNIF01000003_gene2115	2.762e-35	139.0	COG0745@1|root,COG0745@2|Bacteria,3Y53N@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
TLS2_k127_6250080_7	234267.Acid_5371	1.852e-48	179.0	COG1871@1|root,COG1871@2|Bacteria,3Y5E5@57723|Acidobacteria	57723|Acidobacteria	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
TLS2_k127_6250080_5	278963.ATWD01000002_gene329	3.39e-78	270.0	COG1352@1|root,COG1352@2|Bacteria,3Y4GP@57723|Acidobacteria,2JJTD@204432|Acidobacteriia	204432|Acidobacteriia	NT	CheR methyltransferase, all-alpha domain	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
TLS2_k127_6250080_2	452637.Oter_0433	5.81e-140	467.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,46TXM@74201|Verrucomicrobia,3K83U@414999|Opitutae	414999|Opitutae	NT	ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K02487,ko:K03407,ko:K06596	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00507	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
TLS2_k127_6250080_6	234267.Acid_5368	3.149e-52	189.0	COG0835@1|root,COG0835@2|Bacteria,3Y4YS@57723|Acidobacteria	57723|Acidobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
TLS2_k127_6250080_9	234267.Acid_5367	1.435e-38	154.0	COG1406@1|root,COG1406@2|Bacteria	2|Bacteria	N	Chemotaxis phosphatase CheX	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
TLS2_k127_6250080_8	1340493.JNIF01000003_gene3797	1.72e-44	166.0	COG0745@1|root,COG0745@2|Bacteria,3Y55U@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
TLS2_k127_6250080_0	234267.Acid_0343	3.01e-197	631.0	COG1157@1|root,COG1157@2|Bacteria,3Y32E@57723|Acidobacteria	57723|Acidobacteria	NU	TIGRFAM ATPase, FliI YscN family	-	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS2_k127_6250080_10	234267.Acid_0342	1.34e-36	147.0	COG1317@1|root,COG1317@2|Bacteria,3Y5C3@57723|Acidobacteria	57723|Acidobacteria	N	Flagellar assembly protein FliH	-	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
TLS2_k127_6250080_3	234267.Acid_0341	3.106e-115	381.0	COG1536@1|root,COG1536@2|Bacteria,3Y2U7@57723|Acidobacteria	57723|Acidobacteria	N	flagellar motor switch protein FliG	-	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
TLS2_k127_6250080_1	234267.Acid_0340	3.365e-140	464.0	COG1766@1|root,COG1766@2|Bacteria,3Y2HU@57723|Acidobacteria	57723|Acidobacteria	N	The M ring may be actively involved in energy transduction	-	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
TLS2_k127_6250080_13	1200792.AKYF01000011_gene3484	1.039e-09	63.0	COG1677@1|root,COG1677@2|Bacteria,1VEEY@1239|Firmicutes,4HNZW@91061|Bacilli,26ZTW@186822|Paenibacillaceae	91061|Bacilli	N	Flagellar hook-basal body complex protein FliE	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
TLS2_k127_625515_1	1123508.JH636442_gene3989	3.156e-39	160.0	COG1366@1|root,COG2202@1|root,COG3920@1|root,COG1366@2|Bacteria,COG2202@2|Bacteria,COG3920@2|Bacteria,2J004@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2,PAS_4
TLS2_k127_625515_2	858215.Thexy_0441	3.895e-22	109.0	COG4194@1|root,COG4194@2|Bacteria,1UY2R@1239|Firmicutes,24BZZ@186801|Clostridia	186801|Clostridia	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648
TLS2_k127_625515_3	1382304.JNIL01000001_gene1232	5.903e-19	91.0	COG1725@1|root,COG1725@2|Bacteria,1V743@1239|Firmicutes,4HMKR@91061|Bacilli	91061|Bacilli	K	GntR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GntR
TLS2_k127_625515_0	1340493.JNIF01000003_gene4673	4.108e-124	411.0	COG3391@1|root,COG3511@1|root,COG3391@2|Bacteria,COG3511@2|Bacteria,3Y6KG@57723|Acidobacteria	57723|Acidobacteria	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
TLS2_k127_625773_0	1340493.JNIF01000003_gene4600	2.006e-256	831.0	COG1629@1|root,COG4771@2|Bacteria,3Y66U@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_625773_1	1267533.KB906733_gene3179	1.56e-29	124.0	COG1595@1|root,COG1595@2|Bacteria,3Y8VG@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6261993_2	234267.Acid_6692	2.042e-40	158.0	COG4191@1|root,COG4191@2|Bacteria,3Y4SZ@57723|Acidobacteria	57723|Acidobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,dCache_3
TLS2_k127_6261993_1	1267535.KB906767_gene1698	1.278e-64	228.0	COG3794@1|root,COG3794@2|Bacteria,3Y4UD@57723|Acidobacteria,2JJH0@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6261993_0	234267.Acid_6694	8.79e-66	233.0	2E98K@1|root,333GZ@2|Bacteria,3Y55V@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6265796_1	1340493.JNIF01000003_gene4842	1.466e-38	151.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,3Y5S6@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
TLS2_k127_6265796_0	1499967.BAYZ01000061_gene5947	5.5e-42	164.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2NQ8Y@2323|unclassified Bacteria	2|Bacteria	KLT	WD40 repeats	toxC	-	-	ko:K20332	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Pkinase,WD40
TLS2_k127_6276989_4	234267.Acid_0525	3.106e-58	211.0	COG4798@1|root,COG4798@2|Bacteria	2|Bacteria	E	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,FAD_binding_4,Methyltransf_11,Methyltransf_25,Methyltransf_31,SAM_MT
TLS2_k127_6276989_1	1267535.KB906767_gene1154	1.73e-192	608.0	COG0460@1|root,COG0460@2|Bacteria,3Y2VY@57723|Acidobacteria,2JHYQ@204432|Acidobacteriia	204432|Acidobacteriia	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
TLS2_k127_6276989_5	234267.Acid_0533	3.721e-15	81.0	290CR@1|root,2ZN27@2|Bacteria,3Y8Z2@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6276989_2	1035191.HMPREF0185_00318	1.485e-115	384.0	COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,2TTUZ@28211|Alphaproteobacteria,2KFTZ@204458|Caulobacterales	204458|Caulobacterales	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
TLS2_k127_6276989_0	593750.Metfor_1681	3.509e-218	701.0	COG0855@1|root,arCOG04535@2157|Archaea,2XTCF@28890|Euryarchaeota,2N965@224756|Methanomicrobia	224756|Methanomicrobia	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
TLS2_k127_6276989_3	234267.Acid_0872	2.057e-67	252.0	COG1629@1|root,COG4771@2|Bacteria,3Y2QR@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_6279980_2	234267.Acid_0872	1.117e-63	233.0	COG1629@1|root,COG4771@2|Bacteria,3Y2QR@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_6279980_0	1340493.JNIF01000003_gene2517	0.0	1102.0	COG1629@1|root,COG4771@2|Bacteria,3Y3NM@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6279980_1	67356.KL575624_gene2081	1.656e-88	302.0	COG0189@1|root,COG0189@2|Bacteria,2I8TP@201174|Actinobacteria	201174|Actinobacteria	HJ	COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	RimK
TLS2_k127_6288636_0	278963.ATWD01000003_gene34	2.139e-217	711.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_6288636_2	272134.KB731324_gene6669	8.577e-64	224.0	29IJ4@1|root,305GB@2|Bacteria,1G5FB@1117|Cyanobacteria,1HCVP@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF1579)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1579
TLS2_k127_6288636_3	234267.Acid_5527	3.71e-59	207.0	COG2967@1|root,COG2967@2|Bacteria	2|Bacteria	P	mitochondrion morphogenesis	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
TLS2_k127_6288636_1	1458427.BAWN01000018_gene1140	1.967e-148	475.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,2VJ62@28216|Betaproteobacteria,4ACES@80864|Comamonadaceae	28216|Betaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_6295985_4	234267.Acid_7686	7.142e-53	195.0	2F2X8@1|root,33VSU@2|Bacteria,3Y7XB@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6295985_0	234267.Acid_7687	1.68e-128	418.0	COG1131@1|root,COG1131@2|Bacteria,3Y4YH@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6295985_3	234267.Acid_7688	1.447e-81	282.0	COG1277@1|root,COG1277@2|Bacteria,3Y839@57723|Acidobacteria	57723|Acidobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_6295985_1	234267.Acid_7689	1.965e-127	417.0	COG1131@1|root,COG1131@2|Bacteria,3Y6U6@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6295985_2	1267534.KB906759_gene1816	9.698e-110	380.0	COG3712@1|root,COG3712@2|Bacteria,3Y772@57723|Acidobacteria	57723|Acidobacteria	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
TLS2_k127_6296007_1	247490.KSU1_A0055	2.752e-71	249.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	rebM	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_6296007_0	1396141.BATP01000001_gene5350	3.152e-148	480.0	COG0673@1|root,COG0673@2|Bacteria,46S77@74201|Verrucomicrobia,2IU49@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_6296007_3	234267.Acid_6341	1.199e-36	141.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_6296007_2	1267535.KB906767_gene2653	1.466e-67	246.0	COG2912@1|root,COG2912@2|Bacteria,3Y53Z@57723|Acidobacteria,2JMYF@204432|Acidobacteriia	204432|Acidobacteriia	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
TLS2_k127_6313252_5	1340493.JNIF01000003_gene1626	2.524e-12	70.0	COG0577@1|root,COG0577@2|Bacteria,3Y73F@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_6313252_3	234267.Acid_4687	5.815e-40	151.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_6313252_1	909663.KI867150_gene2572	2.804e-61	218.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,42MSW@68525|delta/epsilon subdivisions,2WNY3@28221|Deltaproteobacteria,2MRTF@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Carbonic anhydrase	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS2_k127_6313252_0	234267.Acid_1065	5.507e-179	565.0	COG2876@1|root,COG2876@2|Bacteria,3Y64W@57723|Acidobacteria	57723|Acidobacteria	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
TLS2_k127_6313252_2	234267.Acid_1066	6.766e-57	211.0	28MK6@1|root,33VBX@2|Bacteria,3Y7JM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6313252_4	1267535.KB906767_gene2150	1.799e-19	94.0	COG2335@1|root,COG2335@2|Bacteria	2|Bacteria	M	COG2335, Secreted and surface protein containing fasciclin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	DUF4993,Fasciclin
TLS2_k127_631415_3	1267535.KB906767_gene3220	3.766e-66	241.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_631415_4	926566.Terro_2033	2.006e-36	143.0	COG1695@1|root,COG1695@2|Bacteria,3Y7WH@57723|Acidobacteria,2JP2D@204432|Acidobacteriia	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_631415_2	234267.Acid_3244	1.067e-66	238.0	COG2133@1|root,COG2133@2|Bacteria,3Y7A7@57723|Acidobacteria	57723|Acidobacteria	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_631415_0	1340493.JNIF01000004_gene104	1.02e-115	385.0	COG2768@1|root,COG2768@2|Bacteria,3Y61G@57723|Acidobacteria	57723|Acidobacteria	C	binding domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_631415_1	649638.Trad_1837	1.257e-69	244.0	COG4948@1|root,COG4948@2|Bacteria,1WMNA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Mandelate racemase muconate lactonizing enzyme	ykfB	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_6315355_2	1340493.JNIF01000004_gene17	5.243e-46	172.0	COG1680@1|root,COG1680@2|Bacteria,3Y8A8@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_6315355_0	344747.PM8797T_17112	1.219e-141	473.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6315355_1	1210884.HG799464_gene11116	1.245e-120	403.0	COG2010@1|root,COG2010@2|Bacteria,2J1X8@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_631859_3	204669.Acid345_3266	6.536e-39	146.0	COG0451@1|root,COG0451@2|Bacteria,3Y3Q6@57723|Acidobacteria,2JKMA@204432|Acidobacteriia	204432|Acidobacteriia	GM	Glycosyl hydrolase catalytic core	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_cc
TLS2_k127_631859_0	1121033.AUCF01000021_gene2857	1.817e-115	376.0	COG2227@1|root,COG2227@2|Bacteria,1NN3B@1224|Proteobacteria,2TSKA@28211|Alphaproteobacteria,2JRD4@204441|Rhodospirillales	204441|Rhodospirillales	H	Protein of unknown function (DUF1698)	-	-	-	ko:K15257	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_9
TLS2_k127_631859_1	266779.Meso_2691	1.022e-104	344.0	COG1209@1|root,COG1209@2|Bacteria,1PKBK@1224|Proteobacteria,2TS9M@28211|Alphaproteobacteria,43P0M@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_631859_2	1121106.JQKB01000079_gene2932	2.502e-91	305.0	COG4641@1|root,COG4641@2|Bacteria,1MUW9@1224|Proteobacteria,2TTZM@28211|Alphaproteobacteria,2JPIK@204441|Rhodospirillales	204441|Rhodospirillales	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
TLS2_k127_6319561_0	1403819.BATR01000052_gene1588	6.986e-99	344.0	COG0222@1|root,COG0222@2|Bacteria	2|Bacteria	J	mitochondrial gene expression	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_632590_3	1267535.KB906767_gene2481	1.184e-139	454.0	COG1680@1|root,COG3876@1|root,COG1680@2|Bacteria,COG3876@2|Bacteria,3Y2UC@57723|Acidobacteria,2JIDD@204432|Acidobacteriia	204432|Acidobacteriia	V	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343,SSF
TLS2_k127_632590_1	234267.Acid_4783	2.054e-179	572.0	COG0531@1|root,COG0531@2|Bacteria,3Y2T1@57723|Acidobacteria	57723|Acidobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_632590_0	1340493.JNIF01000003_gene3872	1.835e-213	673.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343,SSF
TLS2_k127_632590_4	1267535.KB906767_gene2477	5.047e-79	280.0	2EM83@1|root,33EX7@2|Bacteria,3Y32M@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_632590_2	1045009.AFXQ01000007_gene2924	2.362e-175	564.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,1W8MR@1268|Micrococcaceae	201174|Actinobacteria	IQ	AMP-binding enzyme	fadD35	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0051087	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_6326378_4	1267535.KB906767_gene697	1.455e-09	62.0	COG4232@1|root,COG4232@2|Bacteria	2|Bacteria	CO	protein-disulfide reductase activity	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
TLS2_k127_6326378_0	234267.Acid_6758	3.808e-152	487.0	COG0416@1|root,COG0416@2|Bacteria,3Y3MM@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
TLS2_k127_6326378_3	234267.Acid_6759	3.383e-28	114.0	COG0333@1|root,COG0333@2|Bacteria,3Y5HY@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
TLS2_k127_6326378_1	234267.Acid_6760	2.799e-53	194.0	COG1399@1|root,COG1399@2|Bacteria,3Y4KJ@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
TLS2_k127_6326378_2	927677.ALVU02000001_gene2460	4.422e-37	143.0	COG1082@1|root,COG1082@2|Bacteria,1G4HG@1117|Cyanobacteria,1H5FH@1142|Synechocystis	1117|Cyanobacteria	G	Xylose isomerase-like TIM barrel	-	-	5.1.3.30,5.1.3.31	ko:K18910	-	-	R10817,R10818	RC03111,RC03283	ko00000,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_633924_2	1267535.KB906767_gene4128	8.456e-134	432.0	2E5U1@1|root,330IC@2|Bacteria	2|Bacteria	S	Sugar-binding cellulase-like	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase-like
TLS2_k127_633924_1	234267.Acid_0426	6.082e-205	649.0	COG3829@1|root,COG3829@2|Bacteria,3Y988@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_9,Sigma54_activat
TLS2_k127_633924_5	234267.Acid_7445	2.819e-61	227.0	COG0589@1|root,COG0589@2|Bacteria,3Y5Y7@57723|Acidobacteria	57723|Acidobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_633924_4	221288.JH992901_gene487	1.249e-82	287.0	COG0778@1|root,COG0778@2|Bacteria,1G5XK@1117|Cyanobacteria,1JKRX@1189|Stigonemataceae	1117|Cyanobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_633924_0	234267.Acid_0167	0.0	1124.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,3Y2Q1@57723|Acidobacteria	57723|Acidobacteria	CJ	Succinyl-CoA ligase like flavodoxin domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
TLS2_k127_633924_3	234267.Acid_4422	9.044e-105	351.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053,ko:K13735	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05100,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220,map05100	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	NHL,SGL,Str_synth
TLS2_k127_633924_6	1125973.JNLC01000012_gene875	6.85e-28	114.0	COG3576@1|root,COG3576@2|Bacteria,1MWG9@1224|Proteobacteria,2TSKK@28211|Alphaproteobacteria,3JRNS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Pyridoxamine 5'-phosphate oxidase	MA20_01375	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
TLS2_k127_634116_2	1121904.ARBP01000009_gene4211	8.185e-12	66.0	COG0308@1|root,COG0308@2|Bacteria,4NFT0@976|Bacteroidetes,47M3W@768503|Cytophagia	976|Bacteroidetes	E	Leukotriene A4 hydrolase, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Leuk-A4-hydro_C,Peptidase_M1
TLS2_k127_634116_0	983545.Glaag_1224	1.532e-54	199.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RSG9@1236|Gammaproteobacteria,464W2@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	aminopeptidase	pepN	-	-	-	-	-	-	-	-	-	-	-	Leuk-A4-hydro_C,Peptidase_M1
TLS2_k127_634116_1	234267.Acid_1382	2.366e-49	188.0	28QZS@1|root,2ZDEJ@2|Bacteria,3Y4BV@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6346932_12	1123242.JH636435_gene1357	1.782e-19	89.0	2DDAB@1|root,2ZHA5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6346932_11	203275.BFO_3146	1.231e-25	119.0	COG1082@1|root,COG2133@1|root,COG1082@2|Bacteria,COG2133@2|Bacteria,4NFKF@976|Bacteroidetes,2FRR2@200643|Bacteroidia,22XIX@171551|Porphyromonadaceae	976|Bacteroidetes	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_6346932_6	927677.ALVU02000001_gene3277	7.452e-64	224.0	COG3871@1|root,COG3871@2|Bacteria,1GBSH@1117|Cyanobacteria	1117|Cyanobacteria	S	Pyridoxamine 5'-phosphate oxidase like	-	-	-	-	-	-	-	-	-	-	-	-	Pyrid_ox_like
TLS2_k127_6346932_8	1340493.JNIF01000003_gene1835	5.946e-56	201.0	COG2128@1|root,COG2128@2|Bacteria,3Y4QA@57723|Acidobacteria	57723|Acidobacteria	P	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	ahpD	-	-	ko:K04756	-	-	-	-	ko00000	-	-	-	CMD
TLS2_k127_6346932_2	234267.Acid_0412	9.348e-92	306.0	COG0450@1|root,COG0450@2|Bacteria,3Y2XI@57723|Acidobacteria	57723|Acidobacteria	O	Redoxin	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
TLS2_k127_6346932_9	1340493.JNIF01000003_gene1837	5.006e-50	181.0	COG0735@1|root,COG0735@2|Bacteria,3Y4W2@57723|Acidobacteria	57723|Acidobacteria	P	Belongs to the Fur family	-	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_6346932_3	234267.Acid_1454	3.018e-88	301.0	COG1651@1|root,COG1651@2|Bacteria,3Y2G9@57723|Acidobacteria	57723|Acidobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DsbC_N,Thioredoxin_4
TLS2_k127_6346932_1	234267.Acid_1455	1.406e-131	437.0	COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,3Y46R@57723|Acidobacteria	57723|Acidobacteria	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PDZ_2,Peptidase_M28
TLS2_k127_6346932_4	1267535.KB906767_gene443	7.663e-86	290.0	COG1738@1|root,COG1738@2|Bacteria,3Y35H@57723|Acidobacteria,2JIRA@204432|Acidobacteriia	204432|Acidobacteriia	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
TLS2_k127_6346932_7	1340493.JNIF01000003_gene3877	1.808e-59	216.0	COG0652@1|root,COG0652@2|Bacteria,3Y30A@57723|Acidobacteria	57723|Acidobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
TLS2_k127_6346932_10	234267.Acid_6496	2.371e-40	157.0	2B707@1|root,3200P@2|Bacteria,3Y4XV@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6346932_0	234267.Acid_6497	3.784e-133	444.0	COG1519@1|root,COG1663@1|root,COG1519@2|Bacteria,COG1663@2|Bacteria,3Y3X5@57723|Acidobacteria	57723|Acidobacteria	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N,LpxK
TLS2_k127_6348578_1	234267.Acid_7677	2.876e-50	188.0	COG1595@1|root,COG1595@2|Bacteria,3Y7UW@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_6348578_0	1303518.CCALI_02789	8.487e-97	331.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_6352863_1	1267535.KB906767_gene3267	2.345e-83	279.0	COG2239@1|root,COG2239@2|Bacteria,3Y7A9@57723|Acidobacteria	57723|Acidobacteria	P	Divalent cation transporter	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE,MgtE_N
TLS2_k127_6352863_0	999419.HMPREF1077_00464	1.346e-189	600.0	COG0673@1|root,COG0673@2|Bacteria,4NH96@976|Bacteroidetes,2G2S5@200643|Bacteroidia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_6352863_2	1232410.KI421412_gene336	1.028e-15	83.0	29SGJ@1|root,2ZKKB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6352863_3	1232410.KI421412_gene337	0.0005817	44.0	2C59E@1|root,2ZDAY@2|Bacteria	2|Bacteria	S	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_6353351_0	234267.Acid_4272	1.063e-59	224.0	COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_6353351_2	314278.NB231_13786	1.274e-07	62.0	2EBAQ@1|root,335BC@2|Bacteria,1RGPY@1224|Proteobacteria,1SDVV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
TLS2_k127_6353351_1	156889.Mmc1_0631	2.24e-39	151.0	COG0784@1|root,COG0784@2|Bacteria,1QVBY@1224|Proteobacteria,2TWVE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
TLS2_k127_6353351_3	983917.RGE_37480	0.0002609	48.0	COG0840@1|root,COG0840@2|Bacteria,1NCMF@1224|Proteobacteria,2VJC0@28216|Betaproteobacteria,1KM2B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NT	chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
TLS2_k127_6361867_0	666681.M301_0483	1.227e-51	199.0	COG4191@1|root,COG4585@1|root,COG4191@2|Bacteria,COG4585@2|Bacteria,1N1PW@1224|Proteobacteria,2VU49@28216|Betaproteobacteria	28216|Betaproteobacteria	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_6361867_1	335543.Sfum_1663	2.518e-21	101.0	COG2197@1|root,COG2197@2|Bacteria,1NDB6@1224|Proteobacteria,4326W@68525|delta/epsilon subdivisions,2X61P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_6361867_2	105559.Nwat_2983	6.122e-21	100.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WX5F@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
TLS2_k127_6371418_3	1267535.KB906767_gene1765	1.135e-18	88.0	COG2887@1|root,COG2887@2|Bacteria	2|Bacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD3	-	-	-	-	-	-	-	-	-	-	-	AAA_19,PDDEXK_1,UvrD-helicase,UvrD_C
TLS2_k127_6371418_0	288000.BBta_1460	4.89e-200	640.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TLS2_k127_6371418_2	234267.Acid_7821	4.608e-38	147.0	COG1555@1|root,COG1555@2|Bacteria,3Y869@57723|Acidobacteria	57723|Acidobacteria	L	Helix-hairpin-helix motif	-	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
TLS2_k127_6371418_1	234267.Acid_7820	4.911e-86	294.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TLS2_k127_63747_2	558173.CDOO_04295	1.5e-15	85.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,22NKJ@1653|Corynebacteriaceae	201174|Actinobacteria	T	Histidine kinase	tcsS5	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS2_k127_63747_0	234267.Acid_7284	2.232e-108	366.0	COG2152@1|root,COG2152@2|Bacteria	2|Bacteria	G	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130,Glyco_hydro_32N,Glyco_hydro_43
TLS2_k127_63747_1	234267.Acid_7283	3.708e-74	252.0	COG0438@1|root,COG0438@2|Bacteria,3Y3CI@57723|Acidobacteria	57723|Acidobacteria	M	glycosyl transferase group 1	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_6377783_5	1267535.KB906767_gene4791	4.66e-30	120.0	COG1413@1|root,COG1413@2|Bacteria,3Y7N7@57723|Acidobacteria	57723|Acidobacteria	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_6377783_1	1267535.KB906767_gene511	1.582e-242	759.0	COG3669@1|root,COG3669@2|Bacteria,3Y3J6@57723|Acidobacteria,2JKNJ@204432|Acidobacteriia	204432|Acidobacteriia	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
TLS2_k127_6377783_2	1340493.JNIF01000003_gene3561	4.824e-175	593.0	COG1629@1|root,COG4771@2|Bacteria,3Y36T@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_6377783_0	1121904.ARBP01000025_gene6118	8.133e-275	864.0	COG1874@1|root,COG1874@2|Bacteria,4NK6M@976|Bacteroidetes,47MV4@768503|Cytophagia	976|Bacteroidetes	G	Beta-galactosidase trimerisation domain	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42M
TLS2_k127_6377783_4	1459636.NTE_01130	8.296e-66	229.0	COG0456@1|root,arCOG00833@2157|Archaea	2157|Archaea	C	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
TLS2_k127_6377783_3	314230.DSM3645_06159	4.104e-74	261.0	COG3119@1|root,COG3119@2|Bacteria,2IXHT@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_6382630_0	29540.C481_11655	4.049e-37	143.0	COG0642@1|root,arCOG06796@1|root,arCOG02358@2157|Archaea,arCOG06192@2157|Archaea,arCOG06796@2157|Archaea,2Y7KE@28890|Euryarchaeota,240TZ@183963|Halobacteria	183963|Halobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_4
TLS2_k127_6382630_3	502025.Hoch_2977	2.133e-05	50.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
TLS2_k127_6382630_2	502025.Hoch_2959	1.842e-09	60.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,4313Z@68525|delta/epsilon subdivisions,2WX2K@28221|Deltaproteobacteria,2Z2QP@29|Myxococcales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_6382630_1	1267535.KB906767_gene2040	1.57e-10	67.0	2CGNP@1|root,32S4A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_639955_2	886293.Sinac_0926	4.623e-48	190.0	COG3119@1|root,COG3119@2|Bacteria,2IXG7@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
TLS2_k127_639955_0	1254432.SCE1572_19820	2.202e-156	499.0	COG4864@1|root,COG4864@2|Bacteria,1MWP0@1224|Proteobacteria,42N9I@68525|delta/epsilon subdivisions,2WK7G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	UPF0365 protein	-	-	-	-	-	-	-	-	-	-	-	-	YdfA_immunity
TLS2_k127_639955_1	1254432.SCE1572_19815	1.236e-129	430.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2WK3H@28221|Deltaproteobacteria,2YZNI@29|Myxococcales	28221|Deltaproteobacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
TLS2_k127_639955_3	1500894.JQNN01000001_gene2426	1.443e-32	141.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VIIX@28216|Betaproteobacteria,473CB@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_6400453_1	1267534.KB906760_gene1581	1.08e-76	274.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8
TLS2_k127_6400453_0	234267.Acid_7276	3.799e-217	691.0	COG0028@1|root,COG0028@2|Bacteria,3Y3GJ@57723|Acidobacteria	2|Bacteria	EH	PFAM Thiamine pyrophosphate	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_6400453_2	517418.Ctha_2038	2.195e-11	70.0	COG2239@1|root,COG2239@2|Bacteria,1FDTZ@1090|Chlorobi	1090|Chlorobi	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
TLS2_k127_6405968_5	935845.JADQ01000032_gene1319	3.5e-19	90.0	COG3256@1|root,COG3256@2|Bacteria,1TSW2@1239|Firmicutes,4HCFR@91061|Bacilli,26WMS@186822|Paenibacillaceae	91061|Bacilli	P	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
TLS2_k127_6405968_2	1382359.JIAL01000001_gene804	6.458e-75	259.0	COG1136@1|root,COG1136@2|Bacteria,3Y3JD@57723|Acidobacteria,2JIHH@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6405968_1	1340493.JNIF01000003_gene4383	2.342e-114	379.0	COG4591@1|root,COG4591@2|Bacteria,3Y3DS@57723|Acidobacteria	57723|Acidobacteria	M	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_6405968_0	234267.Acid_3771	3.958e-156	504.0	COG2010@1|root,COG2010@2|Bacteria,3Y44D@57723|Acidobacteria	57723|Acidobacteria	C	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6405968_3	1340493.JNIF01000003_gene3793	2.913e-55	203.0	COG2010@1|root,COG2010@2|Bacteria,3Y8CD@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6405968_4	1267535.KB906767_gene5086	1.363e-29	119.0	COG4244@1|root,COG4244@2|Bacteria,3Y7HJ@57723|Acidobacteria	57723|Acidobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6407949_1	1267535.KB906767_gene5062	5.637e-24	104.0	COG3668@1|root,COG3668@2|Bacteria	2|Bacteria	D	Plasmid stabilization system	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
TLS2_k127_6407949_0	240015.ACP_3178	6.709e-47	181.0	COG0467@1|root,COG0467@2|Bacteria,3Y2HG@57723|Acidobacteria,2JI5A@204432|Acidobacteriia	204432|Acidobacteriia	T	RepB DNA-primase from phage plasmid	-	-	-	-	-	-	-	-	-	-	-	-	RepB_primase
TLS2_k127_6426303_2	1487953.JMKF01000005_gene594	2.747e-31	128.0	COG1216@1|root,COG1216@2|Bacteria,1G2MT@1117|Cyanobacteria,1H8YG@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
TLS2_k127_6426303_1	794903.OPIT5_15555	1.198e-186	604.0	2DHIW@1|root,2ZZZR@2|Bacteria,46WA6@74201|Verrucomicrobia	794903.OPIT5_15555|-	S	Heparinase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6426303_3	234267.Acid_0095	2.11e-26	112.0	2EMD6@1|root,33F24@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6426303_0	234267.Acid_1388	2.428e-190	606.0	COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	dppX	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
TLS2_k127_6426461_0	1123508.JH636443_gene4982	1.624e-101	336.0	COG0491@1|root,COG0491@2|Bacteria,2IXNH@203682|Planctomycetes	203682|Planctomycetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6426461_1	383372.Rcas_3813	2.204e-71	254.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	stsA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0043170,GO:0044238,GO:0071704,GO:1901576	2.6.1.109	ko:K19715	-	-	R11395	RC00160	ko00000,ko01000,ko01005	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_6430084_2	388051.AUFE01000004_gene894	4.178e-86	288.0	COG0426@1|root,COG0426@2|Bacteria,1MXIE@1224|Proteobacteria,2W9V7@28216|Betaproteobacteria,1K54Q@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_6430084_1	1095769.CAHF01000022_gene305	9.323e-123	398.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2VH8H@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_6430084_3	1166018.FAES_4914	1.775e-50	183.0	COG2318@1|root,COG2318@2|Bacteria,4P4A6@976|Bacteroidetes	976|Bacteroidetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_6430084_0	639030.JHVA01000001_gene1777	4.806e-223	698.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,3Y2IR@57723|Acidobacteria,2JIMR@204432|Acidobacteriia	204432|Acidobacteriia	P	Rhodanese-like domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
TLS2_k127_6431354_0	1267535.KB906767_gene1814	2.835e-190	621.0	COG1629@1|root,COG4771@2|Bacteria,3Y7GJ@57723|Acidobacteria,2JM2Q@204432|Acidobacteriia	204432|Acidobacteriia	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_6431354_3	1210884.HG799468_gene13676	2.55e-08	57.0	COG0673@1|root,COG0673@2|Bacteria,2IXRR@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_6431354_1	344747.PM8797T_18384	1.083e-24	112.0	COG0673@1|root,COG0673@2|Bacteria,2IWRC@203682|Planctomycetes	203682|Planctomycetes	S	COGs COG0673 dehydrogenase and related protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_6431354_2	1220583.GOACH_01_00250	1.453e-15	83.0	COG0599@1|root,COG2084@1|root,COG0599@2|Bacteria,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,4GCIT@85026|Gordoniaceae	201174|Actinobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_6433496_4	1267535.KB906767_gene2464	2.087e-49	178.0	2BQIP@1|root,32JEF@2|Bacteria,3Y6MF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6433496_2	234267.Acid_4108	6.582e-177	571.0	COG1783@1|root,COG1783@2|Bacteria,3Y64R@57723|Acidobacteria	57723|Acidobacteria	S	phage Terminase large subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6433496_8	1123373.ATXI01000010_gene995	8.89e-10	63.0	COG2897@1|root,COG2897@2|Bacteria,2GI56@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_6433496_7	525904.Tter_1818	7.499e-18	94.0	28I4Y@1|root,2Z88D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6433496_6	1267535.KB906767_gene1579	2.176e-30	131.0	COG0457@1|root,COG0457@2|Bacteria	1267535.KB906767_gene1579|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6433496_5	234267.Acid_1212	1.013e-44	176.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	-	-	5.2.1.8	ko:K03769,ko:K03770,ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
TLS2_k127_6433496_1	1267535.KB906767_gene940	6.815e-230	723.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,3Y3QY@57723|Acidobacteria,2JHPJ@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
TLS2_k127_6433496_0	234267.Acid_6602	9.898e-320	999.0	COG3391@1|root,COG3511@1|root,COG3391@2|Bacteria,COG3511@2|Bacteria,3Y2QH@57723|Acidobacteria	57723|Acidobacteria	M	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,Phosphoesterase
TLS2_k127_6433496_3	1267535.KB906767_gene4360	9.949e-56	197.0	COG1449@1|root,COG1449@2|Bacteria,3Y36M@57723|Acidobacteria,2JM7G@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
TLS2_k127_6433626_3	1283300.ATXB01000002_gene2696	4.002e-79	281.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XFKT@135618|Methylococcales	135618|Methylococcales	T	PFAM Chemotaxis methyl-accepting receptor, signalling	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,PAS_3,PAS_8,PAS_9,TarH
TLS2_k127_6433626_2	1340493.JNIF01000003_gene2519	1.049e-88	308.0	COG0457@1|root,COG0457@2|Bacteria,3Y7UM@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
TLS2_k127_6433626_0	1267534.KB906754_gene3673	2.185e-239	770.0	28HBM@1|root,2Z7NK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6433626_4	1408473.JHXO01000013_gene496	1.885e-35	157.0	COG4225@1|root,COG4225@2|Bacteria,4NFWI@976|Bacteroidetes	976|Bacteroidetes	V	Glycosyl Hydrolase Family 88	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6433626_1	278963.ATWD01000001_gene2919	1.674e-129	445.0	COG1629@1|root,COG4771@2|Bacteria,3Y778@57723|Acidobacteria,2JKG8@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6439841_9	234267.Acid_0019	4.68e-09	64.0	2EY4D@1|root,33RD9@2|Bacteria,3Y6DM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6439841_0	234267.Acid_0020	2.328e-186	603.0	COG0457@1|root,COG0457@2|Bacteria,3Y6VN@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6439841_4	1267535.KB906767_gene3422	3.467e-54	199.0	COG3026@1|root,COG3026@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	-	-	-	-	-	-	-	-	-	LolA,LolA_like
TLS2_k127_6439841_7	234267.Acid_4405	3.646e-34	135.0	COG5496@1|root,COG5496@2|Bacteria,3Y96F@57723|Acidobacteria	57723|Acidobacteria	S	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_6439841_3	1267535.KB906767_gene4537	2.712e-60	214.0	COG0328@1|root,COG1057@1|root,COG0328@2|Bacteria,COG1057@2|Bacteria,3Y5D2@57723|Acidobacteria,2JJNT@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_6439841_2	204669.Acid345_1053	3.678e-178	568.0	COG0477@1|root,COG2814@2|Bacteria,3Y34C@57723|Acidobacteria,2JHZ7@204432|Acidobacteriia	204432|Acidobacteriia	EGP	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
TLS2_k127_6439841_8	913865.DOT_5644	1.356e-25	115.0	2ECJ7@1|root,336HA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6439841_5	1122223.KB890687_gene2908	2.138e-53	200.0	COG0412@1|root,COG0412@2|Bacteria,1WM88@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TLS2_k127_6439841_1	1340493.JNIF01000003_gene3635	9.542e-180	569.0	COG2303@1|root,COG2303@2|Bacteria,3Y6FS@57723|Acidobacteria	57723|Acidobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_6451607_5	1294143.H681_09885	8.668e-11	66.0	COG0433@1|root,COG0433@2|Bacteria,1QXYS@1224|Proteobacteria,1SHBS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	KTSC domain	-	-	-	-	-	-	-	-	-	-	-	-	KTSC
TLS2_k127_6451607_2	864069.MicloDRAFT_00070330	9.495e-103	352.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,2UCIY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
TLS2_k127_6451607_0	558169.AGAV01000003_gene2677	1.76e-212	667.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H9NW@91061|Bacilli	91061|Bacilli	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
TLS2_k127_6451607_4	864069.MicloDRAFT_00026920	2.99e-11	68.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
TLS2_k127_6451607_7	266264.Rmet_6564	1.004e-05	51.0	29F37@1|root,3020Z@2|Bacteria,1PIS4@1224|Proteobacteria,2W7BE@28216|Betaproteobacteria,1KE9E@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6451607_1	485916.Dtox_0135	2.481e-121	400.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1UQRR@1239|Firmicutes,24BSD@186801|Clostridia,2645U@186807|Peptococcaceae	186801|Clostridia	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
TLS2_k127_6451607_6	913325.N799_08090	1.456e-07	57.0	COG3240@1|root,COG5571@1|root,COG3240@2|Bacteria,COG5571@2|Bacteria,1MWDI@1224|Proteobacteria,1S2RQ@1236|Gammaproteobacteria,1X3QI@135614|Xanthomonadales	135614|Xanthomonadales	IN	esterase	estA	-	-	ko:K12686	-	-	-	-	ko00000,ko02000,ko02044	1.B.12.8	-	-	Autotransporter,Lipase_GDSL
TLS2_k127_6453315_2	234267.Acid_2225	1.423e-72	249.0	COG2080@1|root,COG2080@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	coxS	-	1.2.5.3,1.3.99.16	ko:K03518,ko:K07302,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_6453315_0	479434.Sthe_1399	4.813e-255	809.0	COG1529@1|root,COG1529@2|Bacteria,2G608@200795|Chloroflexi,27XWN@189775|Thermomicrobia	189775|Thermomicrobia	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_6453315_1	234267.Acid_2227	6.228e-78	273.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_6453315_3	234267.Acid_2228	1.454e-35	146.0	COG3427@1|root,COG3427@2|Bacteria	2|Bacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
TLS2_k127_6463751_0	234267.Acid_1906	8.198e-94	326.0	COG1074@1|root,COG1074@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	-	-	3.1.11.5,3.6.4.12	ko:K01144,ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF3799,PDDEXK_1,UvrD-helicase,UvrD_C
TLS2_k127_6463751_1	234267.Acid_3982	1.806e-38	147.0	COG2084@1|root,COG2084@2|Bacteria,3Y45W@57723|Acidobacteria	57723|Acidobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_6478089_3	1267535.KB906767_gene3994	4.341e-49	178.0	COG0755@1|root,COG0755@2|Bacteria,3Y4FE@57723|Acidobacteria,2JJ1X@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM Cytochrome c assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
TLS2_k127_6478089_0	234267.Acid_3524	1.399e-222	704.0	COG4948@1|root,COG4948@2|Bacteria,3Y403@57723|Acidobacteria	57723|Acidobacteria	M	mandelate racemase muconate lactonizing	-	-	4.2.1.8	ko:K08323	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_6478089_1	1123276.KB893250_gene347	1.388e-140	464.0	COG2133@1|root,COG2133@2|Bacteria,4NDV1@976|Bacteroidetes,47MXD@768503|Cytophagia	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS2_k127_6478089_4	234267.Acid_1037	6.297e-35	138.0	COG1664@1|root,COG1664@2|Bacteria,3Y49V@57723|Acidobacteria	57723|Acidobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS2_k127_6478089_2	1267535.KB906767_gene2652	9.566e-102	332.0	COG0422@1|root,COG0422@2|Bacteria,3Y2TX@57723|Acidobacteria,2JHMC@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
TLS2_k127_6494121_2	909663.KI867149_gene3383	1.171e-06	51.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,42RNC@68525|delta/epsilon subdivisions,2WP7G@28221|Deltaproteobacteria,2MRIV@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Large-conductance mechanosensitive channel, MscL	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
TLS2_k127_6494121_0	234267.Acid_6872	1.421e-294	917.0	2CCP0@1|root,2Z7XN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
TLS2_k127_6494121_1	1267534.KB906755_gene4829	1.578e-103	375.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Dioxygenase_C,TonB_dep_Rec
TLS2_k127_6498856_5	1279009.ADICEAN_02287	7.252e-17	85.0	COG2021@1|root,COG2021@2|Bacteria	2|Bacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_6498856_3	498848.TaqDRAFT_4331	5.102e-22	105.0	COG1404@1|root,COG1404@2|Bacteria,1WJ4U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
TLS2_k127_6498856_0	1267535.KB906767_gene5043	5.35e-174	554.0	COG0542@1|root,COG0542@2|Bacteria,3Y463@57723|Acidobacteria,2JMAK@204432|Acidobacteriia	204432|Acidobacteriia	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
TLS2_k127_6498856_1	1267535.KB906767_gene5044	7.074e-77	264.0	COG4221@1|root,COG4221@2|Bacteria,3Y4DX@57723|Acidobacteria	57723|Acidobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_6498856_2	234267.Acid_3177	1.526e-70	248.0	COG4137@1|root,COG4137@2|Bacteria,3Y9FX@57723|Acidobacteria	57723|Acidobacteria	S	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
TLS2_k127_6498856_4	1121472.AQWN01000003_gene1438	5.969e-20	91.0	COG0373@1|root,COG0373@2|Bacteria,1TQN9@1239|Firmicutes,2496M@186801|Clostridia,2611X@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
TLS2_k127_6507438_0	1340493.JNIF01000003_gene1805	1.888e-234	730.0	COG0542@1|root,COG0542@2|Bacteria,3Y35D@57723|Acidobacteria	57723|Acidobacteria	O	Belongs to the ClpA ClpB family	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS2_k127_6507438_3	234267.Acid_1067	1.497e-142	458.0	COG0329@1|root,COG0329@2|Bacteria,3Y30K@57723|Acidobacteria	57723|Acidobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.1.3.16	ko:K18123	ko00330,ko00630,ko01100,map00330,map00630,map01100	-	R00470,R00471	RC00307,RC00308	ko00000,ko00001,ko01000	-	-	-	DHDPS
TLS2_k127_6507438_12	234267.Acid_0767	4.181e-18	87.0	COG0636@1|root,COG0636@2|Bacteria,3Y59E@57723|Acidobacteria	57723|Acidobacteria	P	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
TLS2_k127_6507438_5	234267.Acid_0766	3.344e-100	331.0	COG0356@1|root,COG0356@2|Bacteria	2|Bacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
TLS2_k127_6507438_14	234267.Acid_0764	5.262e-09	59.0	COG5336@1|root,COG5336@2|Bacteria	2|Bacteria	C	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	atpI	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
TLS2_k127_6507438_7	278963.ATWD01000001_gene3712	1.083e-74	261.0	COG1587@1|root,COG2203@1|root,COG1587@2|Bacteria,COG2203@2|Bacteria,3Y68Z@57723|Acidobacteria,2JK7D@204432|Acidobacteriia	204432|Acidobacteriia	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF,GAF_2,HEM4
TLS2_k127_6507438_8	1210884.HG799462_gene7910	1.529e-59	224.0	COG1520@1|root,COG1520@2|Bacteria,2IYRB@203682|Planctomycetes	2|Bacteria	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_6507438_11	1379698.RBG1_1C00001G0617	7.155e-34	134.0	COG2764@1|root,COG2764@2|Bacteria	2|Bacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_6507438_1	314230.DSM3645_16985	2.022e-185	589.0	COG0477@1|root,COG0477@2|Bacteria,2IWYM@203682|Planctomycetes	203682|Planctomycetes	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_6507438_2	1267535.KB906767_gene552	4.219e-176	589.0	COG1629@1|root,COG4771@2|Bacteria,3Y3Y0@57723|Acidobacteria,2JIYU@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6507438_6	1267535.KB906767_gene3094	3.736e-84	289.0	COG0500@1|root,COG2226@2|Bacteria,3Y44I@57723|Acidobacteria,2JHWJ@204432|Acidobacteriia	204432|Acidobacteriia	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS2_k127_6507438_4	1340493.JNIF01000003_gene2191	2.086e-138	448.0	COG0337@1|root,COG0337@2|Bacteria,3Y2T4@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
TLS2_k127_6507438_10	234267.Acid_7341	7.024e-37	144.0	COG0029@1|root,COG0029@2|Bacteria,3Y39F@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_6507438_9	234267.Acid_7341	6.615e-54	192.0	COG0029@1|root,COG0029@2|Bacteria,3Y39F@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_6521808_2	251221.35211765	7.921e-118	401.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_6521808_1	118168.MC7420_3794	3.292e-220	700.0	COG0296@1|root,COG0296@2|Bacteria,1G0N3@1117|Cyanobacteria,1H6Z3@1150|Oscillatoriales	1117|Cyanobacteria	G	4-alpha-D-((1- 4)-alpha-D-glucano)trehalose trehalohydrolase	treZ	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
TLS2_k127_6521808_0	324602.Caur_1164	6.314e-279	884.0	COG3280@1|root,COG3280@2|Bacteria	2|Bacteria	G	synthase	treY	GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
TLS2_k127_652544_2	234267.Acid_4576	3.911e-43	167.0	COG2010@1|root,COG2010@2|Bacteria,3Y846@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
TLS2_k127_652544_0	234267.Acid_4577	3.891e-212	673.0	COG4993@1|root,COG4993@2|Bacteria,3Y696@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
TLS2_k127_652544_1	1340493.JNIF01000003_gene3842	2.633e-72	249.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PSCyt1,PSCyt2,PSD1
TLS2_k127_6541592_1	1267535.KB906767_gene505	1.242e-142	461.0	COG1793@1|root,COG1793@2|Bacteria,3Y45N@57723|Acidobacteria,2JIH0@204432|Acidobacteriia	204432|Acidobacteriia	L	ATP dependent DNA ligase C terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
TLS2_k127_6541592_2	234267.Acid_5076	1.011e-138	446.0	COG3285@1|root,COG3285@2|Bacteria,3Y74I@57723|Acidobacteria	57723|Acidobacteria	L	dna ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
TLS2_k127_6541592_0	62928.azo0150	1.099e-147	480.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2VK7T@28216|Betaproteobacteria,2KUKS@206389|Rhodocyclales	206389|Rhodocyclales	IQ	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase
TLS2_k127_6547096_3	509635.N824_01560	2.092e-56	220.0	COG0642@1|root,COG2461@1|root,COG3829@1|root,COG2205@2|Bacteria,COG2461@2|Bacteria,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	DUF2249,GAF,GAF_2,HATPase_c,HATPase_c_2,HisKA,HisKA_2,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_6547096_0	1408473.JHXO01000009_gene3444	1.388e-184	586.0	COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,2FPVW@200643|Bacteroidia	976|Bacteroidetes	G	Alpha-L-fucosidase	fucA	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
TLS2_k127_6547096_4	864051.BurJ1DRAFT_3788	1.192e-35	149.0	COG3240@1|root,COG3240@2|Bacteria,1MWDI@1224|Proteobacteria,2VTBY@28216|Betaproteobacteria,1KMED@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	GDSL-like Lipase/Acylhydrolase	-	-	-	ko:K12686	-	-	-	-	ko00000,ko02000,ko02044	1.B.12.8	-	-	Lipase_GDSL,VPEP
TLS2_k127_6547096_5	1172180.KB911786_gene98	1.577e-25	111.0	COG0784@1|root,COG0784@2|Bacteria,2IFH8@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	rcp1	-	-	ko:K02485	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg
TLS2_k127_6547096_2	1385515.N791_10335	3.349e-97	324.0	2C5IF@1|root,2Z9B7@2|Bacteria,1R5AB@1224|Proteobacteria,1S13C@1236|Gammaproteobacteria,1X5C2@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1264)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1264
TLS2_k127_6547096_1	575540.Isop_1158	8.04e-122	394.0	COG1368@1|root,COG1368@2|Bacteria	2|Bacteria	M	sulfuric ester hydrolase activity	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	PMT_2,Sulfatase,Wzy_C
TLS2_k127_6553493_2	1397666.RS24_00079	1.288e-07	54.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,4BT88@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_6553493_0	324057.Pjdr2_4151	1.219e-115	389.0	COG3119@1|root,COG3119@2|Bacteria,1V6NF@1239|Firmicutes,4HKTS@91061|Bacilli,26V7Z@186822|Paenibacillaceae	91061|Bacilli	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_6553493_1	314230.DSM3645_02158	3.909e-75	262.0	COG3119@1|root,COG3119@2|Bacteria,2IXBF@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
TLS2_k127_6554857_3	861360.AARI_04080	1.653e-15	84.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
TLS2_k127_6554857_1	240015.ACP_0708	6.889e-46	171.0	2B4YW@1|root,31XRX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6554857_2	452637.Oter_1887	6.148e-25	112.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_6554857_0	717605.Theco_3672	7.744e-110	367.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4HF4R@91061|Bacilli,27513@186822|Paenibacillaceae	91061|Bacilli	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
TLS2_k127_656296_0	1267535.KB906767_gene5195	1.413e-142	455.0	COG2407@1|root,COG2407@2|Bacteria,3Y63P@57723|Acidobacteria	57723|Acidobacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_656296_2	1267535.KB906767_gene4539	1.414e-50	192.0	COG2823@1|root,COG2823@2|Bacteria,3Y7ZV@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_656296_1	234267.Acid_3431	1.39e-59	212.0	COG0727@1|root,COG0727@2|Bacteria,3Y7XA@57723|Acidobacteria	57723|Acidobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
TLS2_k127_656296_4	234267.Acid_0736	1.443e-17	87.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	pspF	-	-	ko:K03974	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_6574902_0	861299.J421_2157	2.385e-159	526.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,1ZUXK@142182|Gemmatimonadetes	2|Bacteria	T	AAA ATPase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,Trans_reg_C
TLS2_k127_6577475_5	761193.Runsl_1196	1.766e-33	133.0	COG3836@1|root,COG3836@2|Bacteria,4NH2V@976|Bacteroidetes,47JVN@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.20,4.1.2.52,4.1.2.53	ko:K01630,ko:K02510,ko:K12660	ko00051,ko00053,ko00350,ko01120,map00051,map00053,map00350,map01120	-	R01645,R01647,R02261,R02754,R03277	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_6577475_4	1340493.JNIF01000003_gene4294	8.858e-44	163.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_6577475_0	1340493.JNIF01000003_gene4295	5.579e-238	768.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_6577475_3	1157708.KB907457_gene2759	4.097e-56	201.0	COG4430@1|root,COG4430@2|Bacteria,1NEN6@1224|Proteobacteria,2VI9Z@28216|Betaproteobacteria,4ABQ7@80864|Comamonadaceae	28216|Betaproteobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
TLS2_k127_6577475_6	990073.ATHU01000001_gene738	2.898e-24	106.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2YPGD@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
TLS2_k127_6577475_1	1123277.KB893174_gene5952	2.715e-127	423.0	COG3540@1|root,COG3540@2|Bacteria,4PIVI@976|Bacteroidetes,47SNE@768503|Cytophagia	976|Bacteroidetes	P	PhoD-like phosphatase	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
TLS2_k127_6577475_2	756272.Plabr_3011	8.959e-85	289.0	COG1409@1|root,COG1409@2|Bacteria,2IXAB@203682|Planctomycetes	203682|Planctomycetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Metallophos
TLS2_k127_6577475_7	926566.Terro_4035	3.286e-23	106.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6577508_0	234267.Acid_3953	5.42e-250	777.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_6577508_2	1396418.BATQ01000025_gene5256	3.034e-134	442.0	COG1520@1|root,COG1520@2|Bacteria,46UCM@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_6577508_1	204669.Acid345_2910	1.798e-139	454.0	COG2271@1|root,COG2271@2|Bacteria,3Y2VG@57723|Acidobacteria,2JIWZ@204432|Acidobacteriia	204432|Acidobacteriia	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
TLS2_k127_6577508_3	886293.Sinac_0382	3.046e-20	97.0	COG4654@1|root,COG4654@2|Bacteria	2|Bacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PSCyt1,PSCyt2,PSD1
TLS2_k127_6581630_2	240015.ACP_0522	9.951e-47	170.0	COG0667@1|root,COG0667@2|Bacteria,3Y2KB@57723|Acidobacteria,2JJ0N@204432|Acidobacteriia	204432|Acidobacteriia	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_6581630_1	861299.J421_6256	2.692e-59	233.0	COG0515@1|root,COG0515@2|Bacteria,1ZUTN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_8
TLS2_k127_6581630_0	204669.Acid345_4155	1.974e-84	310.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria,2JIZ4@204432|Acidobacteriia	204432|Acidobacteriia	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_6592131_0	1340493.JNIF01000003_gene1761	1.812e-144	471.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TLS2_k127_6592131_1	234267.Acid_2837	3.024e-56	212.0	COG0823@1|root,COG0823@2|Bacteria,3Y89F@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller Repeat	-	-	4.2.2.6	ko:K01730	ko00040,map00040	-	R04382	RC02124,RC02427	ko00000,ko00001,ko01000	-	-	-	PD40
TLS2_k127_6592131_2	65393.PCC7424_3185	1.023e-14	84.0	COG0739@1|root,COG5276@1|root,COG0739@2|Bacteria,COG5276@2|Bacteria,1GQG2@1117|Cyanobacteria,3KKUM@43988|Cyanothece	1117|Cyanobacteria	M	peptidase M10A and M12B matrixin and adamalysin	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Calx-beta
TLS2_k127_6595850_3	1192034.CAP_7606	4.727e-47	173.0	COG0537@1|root,COG0537@2|Bacteria,1PDTP@1224|Proteobacteria,42UAD@68525|delta/epsilon subdivisions,2WQRN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	FG	PFAM Histidine triad (HIT) protein	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
TLS2_k127_6595850_1	398767.Glov_3082	1.409e-89	307.0	COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,42M3Z@68525|delta/epsilon subdivisions,2WJIR@28221|Deltaproteobacteria,43TYS@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
TLS2_k127_6595850_4	1340493.JNIF01000003_gene1455	1.334e-28	127.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	-	-	3.1.3.3,3.1.3.73,5.4.2.12	ko:K02226,ko:K15634,ko:K22305	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00122	R00582,R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TLS2_k127_6595850_5	1121127.JAFA01000037_gene3474	5.187e-27	121.0	COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,2VS93@28216|Betaproteobacteria,1KGVP@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
TLS2_k127_6595850_2	1340493.JNIF01000003_gene4446	2.494e-48	177.0	COG2087@1|root,COG2087@2|Bacteria,3Y746@57723|Acidobacteria	57723|Acidobacteria	H	Cobinamide kinase / cobinamide phosphate guanyltransferase	-	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
TLS2_k127_6595850_0	1340493.JNIF01000003_gene2372	3.624e-94	314.0	COG2271@1|root,COG2271@2|Bacteria,3Y5MH@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_6596320_1	1150864.MILUP08_45906	1.508e-20	100.0	COG0515@1|root,COG0515@2|Bacteria,2HMAN@201174|Actinobacteria,4DHNQ@85008|Micromonosporales	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS2_k127_6596320_0	1340493.JNIF01000003_gene3160	0.0	1049.0	COG1984@1|root,COG1984@2|Bacteria	2|Bacteria	E	allophanate hydrolase subunit 2	kipA	-	6.3.4.6	ko:K01941,ko:K06350	ko00220,ko00791,ko01100,map00220,map00791,map01100	-	R00774	RC00378	ko00000,ko00001,ko01000	-	-	-	CT_A_B,CT_C_D,SLH
TLS2_k127_6596320_2	330214.NIDE0057	4.418e-12	68.0	COG1858@1|root,COG1858@2|Bacteria,3J0GH@40117|Nitrospirae	40117|Nitrospirae	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
TLS2_k127_6596353_2	1340493.JNIF01000003_gene4040	1.549e-31	127.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	rbpA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
TLS2_k127_6596353_0	314230.DSM3645_20627	1.943e-117	394.0	COG1520@1|root,COG1520@2|Bacteria,2IWR8@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_6596353_1	1267535.KB906767_gene5144	6.163e-89	303.0	COG0363@1|root,COG0363@2|Bacteria,3Y51I@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glucosamine galactosamine-6-phosphate isomerase	-	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso
TLS2_k127_6596353_3	234267.Acid_3568	3.046e-05	49.0	COG1682@1|root,COG1682@2|Bacteria	2|Bacteria	GM	macromolecule localization	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
TLS2_k127_6596989_3	1267535.KB906767_gene3843	3.958e-24	107.0	COG1413@1|root,COG1413@2|Bacteria,3Y6AH@57723|Acidobacteria	57723|Acidobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
TLS2_k127_6596989_1	1173028.ANKO01000164_gene2743	2.473e-89	302.0	COG2234@1|root,COG2234@2|Bacteria,1G1QW@1117|Cyanobacteria,1H7N7@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_6596989_0	234267.Acid_3104	2.151e-309	983.0	COG4774@1|root,COG4774@2|Bacteria	2|Bacteria	P	siderophore transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_6596989_2	1476876.JOJO01000008_gene2787	7.446e-89	312.0	COG5434@1|root,COG5434@2|Bacteria,2II7D@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha_L_fucos,CBM_35,F5_F8_type_C,Glyco_hydro_28,Pectate_lyase_3
TLS2_k127_6596989_4	1120973.AQXL01000113_gene762	1.041e-13	78.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,4H9V1@91061|Bacilli	91061|Bacilli	K	Transcriptional	rbsR	-	-	ko:K02529,ko:K03484	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
TLS2_k127_6602244_5	1267535.KB906767_gene2762	1.365e-54	198.0	COG2197@1|root,COG2197@2|Bacteria,3Y8CY@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_6602244_1	1267535.KB906767_gene477	1.387e-179	575.0	COG3119@1|root,COG3119@2|Bacteria,3Y3PF@57723|Acidobacteria,2JIZB@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_6602244_3	234267.Acid_0816	4.426e-94	318.0	COG0697@1|root,COG0697@2|Bacteria,3Y4NT@57723|Acidobacteria	57723|Acidobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_6602244_2	861299.J421_1661	1.327e-157	510.0	COG0534@1|root,COG0534@2|Bacteria,1ZUGI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
TLS2_k127_6602244_0	234267.Acid_1040	8.836e-292	907.0	COG1199@1|root,COG1199@2|Bacteria,3Y3DN@57723|Acidobacteria	57723|Acidobacteria	L	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2
TLS2_k127_6602244_6	1267535.KB906767_gene4079	6.319e-50	184.0	COG0720@1|root,COG0720@2|Bacteria,3Y4HE@57723|Acidobacteria,2JJ9Q@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM 6-pyruvoyl tetrahydropterin	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
TLS2_k127_6602244_4	382464.ABSI01000010_gene3387	5.13e-55	201.0	COG0564@1|root,COG0564@2|Bacteria,46V2B@74201|Verrucomicrobia,2IU67@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	RNA pseudouridylate synthase	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
TLS2_k127_6602244_7	1403819.BATR01000130_gene4642	1.219e-21	100.0	2EK8J@1|root,33DYX@2|Bacteria,46VTQ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6612715_1	234267.Acid_3989	1.974e-142	466.0	COG2006@1|root,COG2006@2|Bacteria,3Y6M1@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
TLS2_k127_6612715_0	1340493.JNIF01000003_gene1719	1.86e-147	481.0	COG1312@1|root,COG1312@2|Bacteria	2|Bacteria	G	mannonate dehydratase activity	uxuA	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
TLS2_k127_6612715_2	498848.TaqDRAFT_4393	5.178e-61	228.0	COG1404@1|root,COG1404@2|Bacteria,1WIDU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	3.4.21.111	ko:K20754	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Inhibitor_I9,Peptidase_S8
TLS2_k127_6620705_2	1123242.JH636435_gene1557	3.162e-74	263.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2IYHP@203682|Planctomycetes	203682|Planctomycetes	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_6620705_3	926560.KE387023_gene2884	3.717e-62	219.0	COG2318@1|root,COG2318@2|Bacteria,1WMM8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_6620705_0	314230.DSM3645_24005	4.023e-93	328.0	COG1520@1|root,COG1520@2|Bacteria,2IYEA@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TLS2_k127_6620705_1	401053.AciPR4_1096	3.131e-92	332.0	COG0823@1|root,COG0823@2|Bacteria,3Y4FU@57723|Acidobacteria,2JJ6C@204432|Acidobacteriia	204432|Acidobacteriia	U	PFAM WD40-like beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40
TLS2_k127_6627588_0	358220.C380_12595	4.055e-178	588.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4AH82@80864|Comamonadaceae	28216|Betaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,Response_reg
TLS2_k127_6627588_3	1121015.N789_06775	3.788e-52	189.0	COG0745@1|root,COG0745@2|Bacteria,1RD6H@1224|Proteobacteria,1S623@1236|Gammaproteobacteria,1X5ZG@135614|Xanthomonadales	135614|Xanthomonadales	KT	two-component system	YH67_17215	-	-	ko:K02485	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg
TLS2_k127_6627588_1	1121013.P873_07315	1.274e-118	407.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1RMUV@1236|Gammaproteobacteria,1XA5I@135614|Xanthomonadales	135614|Xanthomonadales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,PAS_4
TLS2_k127_6627588_4	365046.Rta_16550	4.632e-37	147.0	2E3CB@1|root,32YBM@2|Bacteria,1N6WD@1224|Proteobacteria,2VVST@28216|Betaproteobacteria,4AFTE@80864|Comamonadaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4154)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4154
TLS2_k127_6627588_2	1502852.FG94_02852	1.181e-53	197.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2VH4X@28216|Betaproteobacteria	28216|Betaproteobacteria	P	TonB-dependent receptor	-	-	-	ko:K02014,ko:K16089	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.1,1.B.14.10	-	-	Plug,TonB_dep_Rec
TLS2_k127_6637361_0	935567.JAES01000017_gene2376	4.926e-85	297.0	COG0793@1|root,COG0793@2|Bacteria,1RGID@1224|Proteobacteria,1RYNU@1236|Gammaproteobacteria,1X5PS@135614|Xanthomonadales	135614|Xanthomonadales	M	tail specific protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
TLS2_k127_6637361_4	1040986.ATYO01000021_gene3731	9.793e-19	89.0	COG1396@1|root,COG1396@2|Bacteria,1NGEW@1224|Proteobacteria,2UJFN@28211|Alphaproteobacteria,43M3M@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
TLS2_k127_6637361_1	366602.Caul_1287	2.397e-68	243.0	COG3734@1|root,COG3734@2|Bacteria,1MWGX@1224|Proteobacteria,2TTG8@28211|Alphaproteobacteria,2KGQG@204458|Caulobacterales	204458|Caulobacterales	G	PFAM 2-keto-3-deoxy-galactonokinase	-	-	2.7.1.58	ko:K00883	ko00052,ko01100,map00052,map01100	M00552	R03387	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	DGOK
TLS2_k127_6637361_2	1446473.JHWH01000014_gene2569	1.367e-56	205.0	COG0800@1|root,COG0800@2|Bacteria,1RD0T@1224|Proteobacteria,2U7AQ@28211|Alphaproteobacteria,2PVNW@265|Paracoccus	28211|Alphaproteobacteria	G	Catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate	-	-	4.1.2.21	ko:K01631	ko00052,ko01100,map00052,map01100	M00552	R01064	RC00307,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
TLS2_k127_6642178_0	448385.sce5068	2.521e-77	281.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MX4K@1224|Proteobacteria,42WVW@68525|delta/epsilon subdivisions,2X77J@28221|Deltaproteobacteria,2YUN6@29|Myxococcales	28221|Deltaproteobacteria	P	Outer membrane protein beta-barrel family	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_6642178_2	1340493.JNIF01000003_gene3944	1.875e-12	77.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
TLS2_k127_6642178_1	234267.Acid_6497	1.364e-37	149.0	COG1519@1|root,COG1663@1|root,COG1519@2|Bacteria,COG1663@2|Bacteria,3Y3X5@57723|Acidobacteria	57723|Acidobacteria	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N,LpxK
TLS2_k127_6643161_0	382464.ABSI01000013_gene1532	5.179e-191	638.0	COG3629@1|root,COG3629@2|Bacteria	2|Bacteria	K	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,NACHT,NB-ARC,WD40
TLS2_k127_6643161_1	543526.Htur_1030	5.474e-144	469.0	COG0277@1|root,arCOG00340@2157|Archaea,2Y85H@28890|Euryarchaeota,24157@183963|Halobacteria	183963|Halobacteria	C	COG0277 FAD FMN-containing dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_6655453_0	234267.Acid_5036	1.68e-128	430.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	cya3	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8,Trans_reg_C
TLS2_k127_6659562_2	1340493.JNIF01000003_gene2517	7.228e-136	458.0	COG1629@1|root,COG4771@2|Bacteria,3Y3NM@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6659562_0	1340493.JNIF01000003_gene1440	2.312e-303	942.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	4.2.2.3	ko:K01729	ko00051,map00051	-	R03706	-	ko00000,ko00001,ko01000	-	-	-	Beta_helix,Chondroitinas_B
TLS2_k127_6659562_1	240016.ABIZ01000001_gene3202	7.586e-156	517.0	COG0635@1|root,COG0635@2|Bacteria,46U2R@74201|Verrucomicrobia,2IWKM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_6659562_3	240016.ABIZ01000001_gene2058	4.454e-55	205.0	COG0644@1|root,COG0644@2|Bacteria,46U5W@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
TLS2_k127_6667752_1	1340493.JNIF01000003_gene2630	1.36e-64	227.0	COG1482@1|root,COG1482@2|Bacteria,3Y44Q@57723|Acidobacteria	57723|Acidobacteria	G	Phosphomannose isomerase type I	-	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
TLS2_k127_6667752_0	234267.Acid_7274	5.295e-169	535.0	COG0436@1|root,COG0436@2|Bacteria,3Y2IZ@57723|Acidobacteria	57723|Acidobacteria	E	PFAM aminotransferase, class I	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_6672626_5	179408.Osc7112_4130	4.263e-65	233.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,1G02S@1117|Cyanobacteria,1H8SM@1150|Oscillatoriales	1117|Cyanobacteria	KT	Stage II sporulation protein E	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,SpoIIE
TLS2_k127_6672626_7	886293.Sinac_0763	5.536e-48	179.0	COG2172@1|root,COG2172@2|Bacteria,2J3C4@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K17752	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c
TLS2_k127_6672626_6	204669.Acid345_2415	4.207e-51	186.0	COG1366@1|root,COG1366@2|Bacteria,3Y4YT@57723|Acidobacteria,2JJGC@204432|Acidobacteriia	204432|Acidobacteriia	T	transporter antisigma-factor antagonist STAS	-	-	-	ko:K17762	-	-	-	-	ko00000,ko03021	-	-	-	-
TLS2_k127_6672626_4	1218075.BAYA01000049_gene6763	3.851e-97	327.0	COG1366@1|root,COG1366@2|Bacteria,1MVPW@1224|Proteobacteria,2VNVR@28216|Betaproteobacteria,1K26J@119060|Burkholderiaceae	28216|Betaproteobacteria	T	RsbT co-antagonist protein rsbRD N-terminal domain	rsbRA	-	-	ko:K17763	-	-	-	-	ko00000,ko03021	-	-	-	Protoglobin,RsbRD_N,STAS
TLS2_k127_6672626_1	543728.Vapar_5679	5.157e-170	542.0	COG4948@1|root,COG4948@2|Bacteria,1MVFW@1224|Proteobacteria,2VH6E@28216|Betaproteobacteria,4AA3B@80864|Comamonadaceae	28216|Betaproteobacteria	M	mandelate racemase muconate lactonizing	-	-	4.2.1.81	ko:K22209	-	-	-	-	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_6672626_8	1121946.AUAX01000004_gene892	1.242e-45	172.0	COG0406@1|root,COG0406@2|Bacteria,2IJ7S@201174|Actinobacteria,4DDQU@85008|Micromonosporales	201174|Actinobacteria	G	Histidine phosphatase superfamily (branch 1)	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TLS2_k127_6672626_3	344747.PM8797T_20763	1.141e-113	387.0	COG1331@1|root,COG1331@2|Bacteria,2IXCB@203682|Planctomycetes	203682|Planctomycetes	O	Pectic acid lyase	-	-	-	-	-	-	-	-	-	-	-	-	Pec_lyase
TLS2_k127_6672626_2	1267535.KB906767_gene3133	6.55e-150	514.0	COG1629@1|root,COG4771@2|Bacteria,3Y2R5@57723|Acidobacteria,2JIK7@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6672626_0	1267535.KB906767_gene5488	0.0	1087.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,3Y2JQ@57723|Acidobacteria,2JHR5@204432|Acidobacteriia	204432|Acidobacteriia	E	GXGXG motif	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TLS2_k127_6673780_8	1340493.JNIF01000003_gene2770	9.189e-42	156.0	COG0527@1|root,COG0527@2|Bacteria,3Y34W@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT
TLS2_k127_6673780_4	234267.Acid_6981	6.425e-100	333.0	COG0289@1|root,COG0289@2|Bacteria,3Y50R@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the DapB family	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
TLS2_k127_6673780_6	768670.Calni_1811	1.853e-83	287.0	COG0329@1|root,COG0329@2|Bacteria,2GF1R@200930|Deferribacteres	200930|Deferribacteres	H	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_6673780_1	1267535.KB906767_gene2122	8.555e-125	407.0	COG2171@1|root,COG2171@2|Bacteria,3Y2Z3@57723|Acidobacteria,2JIDV@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the transferase hexapeptide repeat family	-	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep_2,THDPS_N_2
TLS2_k127_6673780_2	234267.Acid_7123	6.032e-119	392.0	COG0438@1|root,COG0438@2|Bacteria,3Y867@57723|Acidobacteria	57723|Acidobacteria	H	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_6673780_0	234267.Acid_7122	9.199e-144	475.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_7122|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6673780_5	234267.Acid_7120	4.677e-95	320.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
TLS2_k127_6673780_3	234267.Acid_7119	4.843e-111	368.0	COG1216@1|root,COG1216@2|Bacteria,3Y7YU@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6673780_7	234267.Acid_0593	2.754e-74	256.0	28JXN@1|root,30T38@2|Bacteria,3Y61P@57723|Acidobacteria	57723|Acidobacteria	S	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
TLS2_k127_6681507_3	401053.AciPR4_0809	2.637e-10	63.0	COG3182@1|root,COG3182@2|Bacteria,3Y2R7@57723|Acidobacteria,2JIBB@204432|Acidobacteriia	204432|Acidobacteriia	S	PepSY-associated TM region	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_TM
TLS2_k127_6681507_0	1267535.KB906767_gene5221	0.0	1304.0	COG1352@1|root,COG2201@1|root,COG4585@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	cheB	-	2.1.1.80,3.1.1.61,3.5.1.44	ko:K03412,ko:K03413,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,HisKA_3,PAS,PAS_10,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
TLS2_k127_6681507_1	1173028.ANKO01000159_gene5200	9.545e-76	264.0	COG2201@1|root,COG2201@2|Bacteria,1G3H5@1117|Cyanobacteria,1HAH2@1150|Oscillatoriales	1117|Cyanobacteria	NT	CheB methylesterase	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest
TLS2_k127_6681507_2	234267.Acid_2867	3.879e-48	183.0	2EIAS@1|root,33C26@2|Bacteria,3Y5X7@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6691043_6	1340493.JNIF01000003_gene2576	9.054e-08	64.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	DUF11,VCBS
TLS2_k127_6691043_5	234267.Acid_0847	1.109e-12	73.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,Kelch_4
TLS2_k127_6691043_2	1267535.KB906767_gene1604	1.04e-52	190.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
TLS2_k127_6691043_3	1267533.KB906733_gene3362	7.794e-21	106.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS2_k127_6691043_4	278963.ATWD01000001_gene2770	3.321e-16	91.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria,2JIZ4@204432|Acidobacteriia	204432|Acidobacteriia	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_6691043_1	926554.KI912671_gene275	2.164e-114	381.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta
TLS2_k127_6691043_0	1340493.JNIF01000004_gene779	4.954e-147	475.0	COG1921@1|root,COG1921@2|Bacteria,3Y2SF@57723|Acidobacteria	57723|Acidobacteria	E	L-seryl-tRNASec selenium transferase activity	-	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,SelA
TLS2_k127_6693489_2	396588.Tgr7_3277	1.551e-11	68.0	COG3166@1|root,COG3166@2|Bacteria,1PM32@1224|Proteobacteria,1TKD8@1236|Gammaproteobacteria,1X1ZM@135613|Chromatiales	135613|Chromatiales	NU	PFAM Fimbrial assembly family protein	-	-	-	-	-	-	-	-	-	-	-	-	PilN
TLS2_k127_6693489_0	1382359.JIAL01000001_gene1745	9.183e-131	454.0	COG0612@1|root,COG0612@2|Bacteria,3Y2UB@57723|Acidobacteria,2JITC@204432|Acidobacteriia	204432|Acidobacteriia	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_6693489_1	204669.Acid345_0604	2.574e-61	220.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y3HX@57723|Acidobacteria,2JHJ9@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,TPR_8
TLS2_k127_671899_4	518766.Rmar_1256	2.268e-62	224.0	COG0053@1|root,COG0053@2|Bacteria,4NEID@976|Bacteroidetes,1FJ56@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TLS2_k127_671899_2	234267.Acid_4725	6.2e-122	398.0	COG0709@1|root,COG0709@2|Bacteria,3Y6V3@57723|Acidobacteria	57723|Acidobacteria	E	AIR synthase related protein, C-terminal domain	-	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
TLS2_k127_671899_3	1267535.KB906767_gene1125	1.241e-80	276.0	COG0284@1|root,COG0284@2|Bacteria,3Y2XD@57723|Acidobacteria,2JIQY@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
TLS2_k127_671899_0	616991.JPOO01000003_gene1738	8.594e-183	593.0	COG2730@1|root,COG2730@2|Bacteria,4NF3J@976|Bacteroidetes,1I1P4@117743|Flavobacteriia	976|Bacteroidetes	G	Protein of unknown function (DUF4038)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038
TLS2_k127_671899_1	1340493.JNIF01000003_gene4439	6.988e-144	476.0	COG1492@1|root,COG1492@2|Bacteria,3Y64K@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
TLS2_k127_671899_5	290315.Clim_1068	4.443e-08	58.0	COG1270@1|root,COG1270@2|Bacteria,1FE2K@1090|Chlorobi	1090|Chlorobi	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
TLS2_k127_6719128_0	743721.Psesu_1282	2.975e-132	436.0	COG1629@1|root,COG4771@2|Bacteria,1PSM0@1224|Proteobacteria,1T0NW@1236|Gammaproteobacteria,1X3X1@135614|Xanthomonadales	135614|Xanthomonadales	P	Outer membrane receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_6719128_4	285535.JOEY01000035_gene3715	1.271e-05	48.0	COG0477@1|root,COG0477@2|Bacteria,2H6BY@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_6719128_2	95619.PM1_0220195	2.737e-57	201.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,1S6Y1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator	VL23_01195	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_6719128_3	318161.Sden_1604	2.336e-43	160.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,1S61Z@1236|Gammaproteobacteria,2QC5B@267890|Shewanellaceae	1236|Gammaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_6719128_1	349124.Hhal_0432	1.829e-64	227.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1WW51@135613|Chromatiales	135613|Chromatiales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
TLS2_k127_6721182_2	1340493.JNIF01000004_gene211	7.114e-52	188.0	COG0795@1|root,COG0795@2|Bacteria,3Y2F9@57723|Acidobacteria	57723|Acidobacteria	S	Permease, YjgP YjgQ	-	-	-	-	-	-	-	-	-	-	-	-	YjgP_YjgQ
TLS2_k127_6721182_1	234267.Acid_5820	5.005e-161	526.0	COG0312@1|root,COG0312@2|Bacteria,3Y686@57723|Acidobacteria	57723|Acidobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
TLS2_k127_6721182_0	234267.Acid_5819	2.731e-210	668.0	COG0312@1|root,COG0312@2|Bacteria,3Y3MT@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
TLS2_k127_6721182_3	1267535.KB906767_gene959	1.9e-49	184.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02479,ko:K07684,ko:K07685	ko02020,map02020	M00471,M00472	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
TLS2_k127_6721182_4	1380386.JIAW01000032_gene3449	8.021e-08	59.0	COG4857@1|root,COG4857@2|Bacteria,2INGW@201174|Actinobacteria,23E0V@1762|Mycobacteriaceae	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	2.7.1.100	ko:K00899	ko00270,ko01100,map00270,map01100	M00034	R04143	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
TLS2_k127_6726451_2	379066.GAU_2122	9.252e-88	297.0	COG3508@1|root,COG3508@2|Bacteria,1ZTFN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	homogentisate 1,2-dioxygenase	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
TLS2_k127_6726451_1	1121930.AQXG01000008_gene184	2.003e-135	441.0	COG3185@1|root,COG3185@2|Bacteria,4NFI7@976|Bacteroidetes,1IPBI@117747|Sphingobacteriia	976|Bacteroidetes	E	4-hydroxyphenylpyruvate dioxygenase	hppD	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
TLS2_k127_6726451_0	518766.Rmar_1427	1.32e-222	706.0	COG0365@1|root,COG0365@2|Bacteria,4NEAD@976|Bacteroidetes,1FIMS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_6726451_3	1340493.JNIF01000003_gene3863	2.672e-61	221.0	COG2197@1|root,COG2197@2|Bacteria,3Y59X@57723|Acidobacteria	57723|Acidobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_6726451_4	1340493.JNIF01000003_gene3862	3.181e-61	217.0	COG4191@1|root,COG4191@2|Bacteria,3Y499@57723|Acidobacteria	57723|Acidobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_8
TLS2_k127_6726722_1	1267535.KB906767_gene985	6.072e-30	121.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	GO:0003674,GO:0003824,GO:0004747,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019303,GO:0019321,GO:0019323,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.15,2.7.1.4	ko:K00847,ko:K00852	ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100	-	R00760,R00867,R01051,R02750,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iE2348C_1286.E2348C_4062,iEcDH1_1363.EcDH1_4215	PfkB
TLS2_k127_6726722_0	1267535.KB906767_gene4159	3.773e-74	255.0	COG2952@1|root,COG2952@2|Bacteria,3Y55F@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF507)	-	-	-	ko:K09804	-	-	-	-	ko00000	-	-	-	DUF507
TLS2_k127_6726722_2	1124780.ANNU01000069_gene1092	1.676e-21	102.0	2E3Q4@1|root,32YN3@2|Bacteria,4NVYD@976|Bacteroidetes,47RSR@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6739584_1	1267535.KB906767_gene3334	1.314e-317	991.0	COG1449@1|root,COG1449@2|Bacteria,3Y2JJ@57723|Acidobacteria,2JHW6@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
TLS2_k127_6739584_3	234267.Acid_5530	9.998e-143	464.0	COG0475@1|root,COG0475@2|Bacteria,3Y5D3@57723|Acidobacteria	57723|Acidobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS2_k127_6739584_8	225849.swp_3691	4.072e-23	110.0	COG4271@1|root,COG4271@2|Bacteria,1R4Z7@1224|Proteobacteria,1SAF8@1236|Gammaproteobacteria,2QC4F@267890|Shewanellaceae	1236|Gammaproteobacteria	K	Predicted nucleotide-binding protein containing TIR-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR-like,cNMP_binding
TLS2_k127_6739584_5	926566.Terro_0014	5.362e-68	238.0	2AYX9@1|root,31R2Z@2|Bacteria,3Y4ZH@57723|Acidobacteria,2JJGK@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_6739584_6	1267535.KB906767_gene5106	1.371e-60	211.0	COG1695@1|root,COG1695@2|Bacteria,3Y7YK@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_6739584_0	1267535.KB906767_gene5107	0.0	1096.0	COG0577@1|root,COG0577@2|Bacteria,3Y76A@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_6739584_2	1267535.KB906767_gene1540	3.715e-215	707.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6739584_4	1123242.JH636434_gene5158	1.95e-115	382.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2
TLS2_k127_6739584_7	1163409.UUA_08346	2.948e-29	129.0	COG0823@1|root,COG0823@2|Bacteria,1MWYK@1224|Proteobacteria,1RXYW@1236|Gammaproteobacteria,1XD03@135614|Xanthomonadales	135614|Xanthomonadales	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
TLS2_k127_6762739_2	234267.Acid_3353	6.033e-54	192.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,3Y2I2@57723|Acidobacteria	57723|Acidobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
TLS2_k127_6762739_1	1340493.JNIF01000003_gene3781	2.912e-82	284.0	COG0084@1|root,COG0084@2|Bacteria,3Y4DK@57723|Acidobacteria	57723|Acidobacteria	L	Hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
TLS2_k127_6762739_0	1267535.KB906767_gene5353	3.531e-134	434.0	COG0142@1|root,COG0142@2|Bacteria,3Y2VJ@57723|Acidobacteria,2JHS0@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_6773386_2	234267.Acid_6854	4.966e-221	723.0	COG1629@1|root,COG4771@2|Bacteria,3Y477@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_6773386_0	1340493.JNIF01000003_gene1534	1.305e-289	900.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	BNR,BNR_2,CBM_2,RicinB_lectin_2
TLS2_k127_6773386_3	743719.PaelaDRAFT_1372	9.825e-91	320.0	COG3119@1|root,COG3119@2|Bacteria,1V6NF@1239|Firmicutes,4HKTS@91061|Bacilli,26V7Z@186822|Paenibacillaceae	91061|Bacilli	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_6773386_1	204669.Acid345_0326	1.172e-229	722.0	COG2160@1|root,COG2160@2|Bacteria,3Y3QU@57723|Acidobacteria,2JIU4@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the conversion of L-arabinose to L-ribulose	araA	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Iso_C,Arabinose_Isome
TLS2_k127_6773386_4	234267.Acid_3282	8.854e-51	185.0	COG1082@1|root,COG1082@2|Bacteria,3Y688@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_6789889_0	521674.Plim_0518	7.193e-188	596.0	COG4102@1|root,COG4102@2|Bacteria,2J4YY@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_6789889_1	521674.Plim_0517	2.721e-126	411.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PSCyt1,PSCyt2,PSD1
TLS2_k127_6790195_3	1340493.JNIF01000003_gene2272	1.937e-40	151.0	COG4555@1|root,COG4555@2|Bacteria,3Y9E2@57723|Acidobacteria	57723|Acidobacteria	CP	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_6790195_1	1340493.JNIF01000003_gene2271	4.152e-56	211.0	COG1668@1|root,COG1668@2|Bacteria,3Y8H3@57723|Acidobacteria	57723|Acidobacteria	CP	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
TLS2_k127_6790195_0	234267.Acid_1760	2.002e-63	234.0	COG0566@1|root,COG0566@2|Bacteria,3Y4WG@57723|Acidobacteria	57723|Acidobacteria	J	SpoU rRNA Methylase family	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
TLS2_k127_6790195_2	1267535.KB906767_gene2147	1.385e-54	203.0	COG1503@1|root,COG1503@2|Bacteria,3Y81Y@57723|Acidobacteria,2JND0@204432|Acidobacteriia	204432|Acidobacteriia	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6794857_5	1267535.KB906767_gene5099	1.265e-31	134.0	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_6794857_4	472759.Nhal_2424	6.662e-32	128.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S8RQ@1236|Gammaproteobacteria,1WZ4Z@135613|Chromatiales	135613|Chromatiales	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TLS2_k127_6794857_1	1331060.RLDS_11615	8.444e-43	160.0	COG1993@1|root,COG1993@2|Bacteria,1N0EM@1224|Proteobacteria,2U9WX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
TLS2_k127_6794857_0	357808.RoseRS_3832	1.341e-106	353.0	COG1131@1|root,COG1131@2|Bacteria,2G6HN@200795|Chloroflexi,3768T@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K01990,ko:K16907	ko02010,map02010	M00224,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6794857_3	357808.RoseRS_3831	6.074e-37	149.0	COG1668@1|root,COG1668@2|Bacteria,2GBSB@200795|Chloroflexi,376EX@32061|Chloroflexia	32061|Chloroflexia	CP	transmembrane transport	-	-	-	ko:K16906	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_6794857_2	383372.Rcas_0972	1.582e-40	160.0	COG0474@1|root,COG0474@2|Bacteria,2GAPR@200795|Chloroflexi,376Z7@32061|Chloroflexia	32061|Chloroflexia	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	-	-	-	ko:K16905	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_6804929_3	1245471.PCA10_03010	1.862e-108	357.0	COG0031@1|root,COG0517@1|root,COG0031@2|Bacteria,COG0517@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1YFIF@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
TLS2_k127_6804929_1	1183438.GKIL_3015	1.124e-182	577.0	COG0626@1|root,COG0626@2|Bacteria,1G43Q@1117|Cyanobacteria	1117|Cyanobacteria	E	cystathionine	metB	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
TLS2_k127_6804929_8	1500304.JQKY01000003_gene339	1.532e-38	149.0	COG1595@1|root,COG1595@2|Bacteria,1MXVA@1224|Proteobacteria,2TV85@28211|Alphaproteobacteria,4BAXG@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigJ	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6804929_4	1382359.JIAL01000001_gene2918	3.562e-69	240.0	COG2128@1|root,COG2128@2|Bacteria,3Y4TK@57723|Acidobacteria,2JJJ6@204432|Acidobacteriia	204432|Acidobacteriia	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_6804929_2	234267.Acid_5876	8.276e-153	488.0	COG0667@1|root,COG0667@2|Bacteria,3Y3KW@57723|Acidobacteria	57723|Acidobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_6804929_5	1267535.KB906767_gene3861	5.906e-62	221.0	COG4103@1|root,COG4103@2|Bacteria	2|Bacteria	T	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
TLS2_k127_6804929_10	1267535.KB906767_gene194	1.919e-27	115.0	COG2975@1|root,COG2975@2|Bacteria	2|Bacteria	S	iron-sulfur cluster assembly	iscX	GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772	-	-	-	-	-	-	-	-	-	-	Fe-S_assembly
TLS2_k127_6804929_0	1267535.KB906767_gene195	5.018e-279	869.0	COG0443@1|root,COG0443@2|Bacteria,3Y2F8@57723|Acidobacteria,2JIVF@204432|Acidobacteriia	204432|Acidobacteriia	O	heat shock protein 70	-	-	-	ko:K04043,ko:K04044	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33,1.A.33.1	-	-	HSP70
TLS2_k127_6804929_6	1267535.KB906767_gene196	7.467e-49	182.0	COG1076@1|root,COG1076@2|Bacteria,3Y4MR@57723|Acidobacteria,2JJBF@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM heat shock protein DnaJ	-	-	-	ko:K04082	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,HSCB_C
TLS2_k127_6804929_7	1267535.KB906767_gene197	6.706e-46	168.0	COG0316@1|root,COG0316@2|Bacteria,3Y518@57723|Acidobacteria,2JJGN@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TLS2_k127_6804929_9	1267535.KB906767_gene198	9.852e-37	139.0	COG0822@1|root,COG0822@2|Bacteria,3Y4B9@57723|Acidobacteria,2JJ45@204432|Acidobacteriia	204432|Acidobacteriia	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS2_k127_6810165_2	234267.Acid_2277	5.946e-88	297.0	COG1136@1|root,COG1136@2|Bacteria,3Y412@57723|Acidobacteria	57723|Acidobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
TLS2_k127_6810165_0	1122605.KB893625_gene1625	3.021e-126	421.0	COG3119@1|root,COG3119@2|Bacteria,4NE7S@976|Bacteroidetes	976|Bacteroidetes	P	COG COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase
TLS2_k127_6810165_1	234267.Acid_6854	1.126e-92	317.0	COG1629@1|root,COG4771@2|Bacteria,3Y477@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_6816509_0	497964.CfE428DRAFT_5426	4.459e-90	318.0	COG1680@1|root,COG1680@2|Bacteria,46WGY@74201|Verrucomicrobia	74201|Verrucomicrobia	V	COG1680 Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6816509_1	56780.SYN_01126	1.326e-30	139.0	COG3204@1|root,COG3204@2|Bacteria,1QVA9@1224|Proteobacteria	1224|Proteobacteria	L	pilus organization	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6820740_0	234267.Acid_2598	2.528e-140	451.0	COG0331@1|root,COG0331@2|Bacteria,3Y2TE@57723|Acidobacteria	57723|Acidobacteria	I	malonyl CoA-acyl carrier protein transacylase	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
TLS2_k127_6820740_2	234267.Acid_1082	8.209e-64	224.0	COG0424@1|root,COG0424@2|Bacteria,3Y4ZU@57723|Acidobacteria	57723|Acidobacteria	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
TLS2_k127_6820740_1	204669.Acid345_2850	3.131e-72	257.0	COG0392@1|root,COG0392@2|Bacteria,3Y78T@57723|Acidobacteria	57723|Acidobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS2_k127_682469_1	251221.35210593	2.135e-82	297.0	COG0642@1|root,COG0784@1|root,COG2203@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg,dCache_1
TLS2_k127_682469_0	1267535.KB906767_gene339	1.633e-147	471.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS2_k127_6830211_3	234267.Acid_4010	6.214e-159	510.0	COG3534@1|root,COG3534@2|Bacteria	2|Bacteria	G	alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
TLS2_k127_6830211_4	521674.Plim_0121	3.855e-133	437.0	2A5IZ@1|root,30U97@2|Bacteria,2J2QZ@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6830211_2	1267535.KB906767_gene5278	7.135e-179	578.0	COG0508@1|root,COG0508@2|Bacteria,3Y3CV@57723|Acidobacteria,2JHPY@204432|Acidobacteriia	204432|Acidobacteriia	C	e3 binding domain	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_6830211_7	1449126.JQKL01000058_gene2233	6.017e-58	209.0	COG0321@1|root,COG0321@2|Bacteria,1V44P@1239|Firmicutes,24GE9@186801|Clostridia	186801|Clostridia	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TLS2_k127_6830211_1	1267535.KB906767_gene5276	5.471e-232	724.0	COG1249@1|root,COG1249@2|Bacteria,3Y2M8@57723|Acidobacteria,2JIAI@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_6830211_5	357808.RoseRS_0952	1.741e-124	409.0	COG2605@1|root,COG2605@2|Bacteria	2|Bacteria	G	GHMP kinase	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_6830211_0	1340493.JNIF01000004_gene294	1.178e-288	898.0	COG0591@1|root,COG0591@2|Bacteria,3Y4WN@57723|Acidobacteria	57723|Acidobacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_6830211_6	234267.Acid_5494	1.556e-95	320.0	COG3622@1|root,COG3622@2|Bacteria,3Y6XP@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_6830211_8	543632.JOJL01000010_gene7164	1.063e-13	74.0	COG3959@1|root,COG3959@2|Bacteria,2GJ6M@201174|Actinobacteria,4DDKR@85008|Micromonosporales	201174|Actinobacteria	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS2_k127_6838472_0	1340493.JNIF01000004_gene232	2.117e-202	644.0	COG0405@1|root,COG0405@2|Bacteria,3Y2N0@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Gamma-glutamyltranspeptidase	-	-	-	-	-	-	-	-	-	-	-	-	G_glu_transpept
TLS2_k127_6838472_1	1185876.BN8_03291	3.791e-59	211.0	COG2162@1|root,COG2162@2|Bacteria,4NPEY@976|Bacteroidetes,47QTB@768503|Cytophagia	976|Bacteroidetes	Q	Belongs to the arylamine N-acetyltransferase family	nat	-	2.3.1.118	ko:K00675	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_2
TLS2_k127_6841947_0	234267.Acid_1371	5.554e-120	389.0	COG0451@1|root,COG0451@2|Bacteria,3Y3T4@57723|Acidobacteria	57723|Acidobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_6841947_1	1340493.JNIF01000003_gene4320	3.93e-84	286.0	COG1321@1|root,COG1321@2|Bacteria,3Y5SN@57723|Acidobacteria	57723|Acidobacteria	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
TLS2_k127_6851924_7	1123508.JH636442_gene4191	3.635e-62	216.0	COG3591@1|root,COG3591@2|Bacteria,2IXPD@203682|Planctomycetes	203682|Planctomycetes	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
TLS2_k127_6851924_4	661478.OP10G_0669	6.364e-104	344.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_6851924_6	661478.OP10G_0668	2.255e-65	231.0	COG4914@1|root,COG4914@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204,NTP_transf_5
TLS2_k127_6851924_5	1123368.AUIS01000004_gene277	1.962e-87	300.0	2EZQR@1|root,33SVP@2|Bacteria,1NQXS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6851924_3	290397.Adeh_1016	2.642e-106	367.0	COG0438@1|root,COG5653@1|root,COG0438@2|Bacteria,COG5653@2|Bacteria,1MWSZ@1224|Proteobacteria,4309V@68525|delta/epsilon subdivisions,2WVBY@28221|Deltaproteobacteria,2YZHG@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_6851924_8	414684.RC1_0774	3.185e-51	190.0	COG2120@1|root,COG2120@2|Bacteria,1RJX0@1224|Proteobacteria,2UA4M@28211|Alphaproteobacteria,2JXQF@204441|Rhodospirillales	204441|Rhodospirillales	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_6851924_0	1267535.KB906767_gene448	1.321e-290	899.0	COG0595@1|root,COG0595@2|Bacteria,3Y2NH@57723|Acidobacteria,2JI53@204432|Acidobacteriia	204432|Acidobacteriia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
TLS2_k127_6851924_1	1340493.JNIF01000003_gene1340	2.301e-148	481.0	COG0277@1|root,COG0277@2|Bacteria,3Y766@57723|Acidobacteria	57723|Acidobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_6851924_2	290397.Adeh_4305	1.708e-115	387.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2WJ3T@28221|Deltaproteobacteria,2YZCY@29|Myxococcales	28221|Deltaproteobacteria	C	UDP binding domain	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS2_k127_6851924_9	290512.Paes_1105	6.413e-12	76.0	COG0457@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3903@2|Bacteria,1FD7Y@1090|Chlorobi	1090|Chlorobi	K	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,TIR_2,TPR_12,TPR_7
TLS2_k127_6859760_1	483219.LILAB_14420	4.844e-07	61.0	COG3391@1|root,COG3533@1|root,COG3391@2|Bacteria,COG3533@2|Bacteria,1Q2JN@1224|Proteobacteria,4386H@68525|delta/epsilon subdivisions,2X9ZH@28221|Deltaproteobacteria,2YVZH@29|Myxococcales	28221|Deltaproteobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Stig1
TLS2_k127_6859760_0	1340493.JNIF01000003_gene1425	1.227e-07	62.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4375,HEAT_2
TLS2_k127_6866234_2	234267.Acid_7865	3.11e-71	252.0	COG4585@1|root,COG4585@2|Bacteria,3Y59R@57723|Acidobacteria	2|Bacteria	T	PFAM ATP-binding region, ATPase domain protein domain protein	-	-	2.7.13.3	ko:K07683	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF_2,HATPase_c,HisKA_3,PAS,PAS_4,PAS_9,Pkinase
TLS2_k127_6866234_0	234267.Acid_7866	1.487e-78	273.0	COG2197@1|root,COG2197@2|Bacteria,3Y6T2@57723|Acidobacteria	57723|Acidobacteria	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_6866234_1	1267535.KB906767_gene3904	3.071e-75	258.0	COG0634@1|root,COG0634@2|Bacteria,3Y2FD@57723|Acidobacteria,2JJ7Z@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS2_k127_6866234_4	1267535.KB906767_gene3549	4.272e-45	168.0	COG0799@1|root,COG0799@2|Bacteria,3Y5SD@57723|Acidobacteria	57723|Acidobacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
TLS2_k127_6866943_0	1267535.KB906767_gene1569	1.951e-225	721.0	COG2234@1|root,COG2234@2|Bacteria,3Y435@57723|Acidobacteria	57723|Acidobacteria	S	Transferrin receptor-like dimerisation domain	-	-	3.4.17.21	ko:K01301	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28,TFR_dimer
TLS2_k127_6866943_1	234267.Acid_6757	9.437e-223	705.0	COG0526@1|root,COG4232@1|root,COG0526@2|Bacteria,COG4232@2|Bacteria,3Y2KW@57723|Acidobacteria	57723|Acidobacteria	CO	Thioredoxin-like	-	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
TLS2_k127_6870276_0	204669.Acid345_3767	8.837e-169	540.0	COG0312@1|root,COG0312@2|Bacteria,3Y6TF@57723|Acidobacteria	57723|Acidobacteria	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS2_k127_6870276_2	234267.Acid_7348	1.785e-35	137.0	COG4031@1|root,COG4031@2|Bacteria,3Y8JK@57723|Acidobacteria	57723|Acidobacteria	S	Predicted metal-binding protein (DUF2103)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2103
TLS2_k127_6870276_1	1340493.JNIF01000003_gene3620	1.591e-135	442.0	COG2911@1|root,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	AsmA_2,DUF748,TamB
TLS2_k127_6873876_2	450851.PHZ_c1594	6.324e-72	246.0	COG1878@1|root,COG1878@2|Bacteria,1R8IH@1224|Proteobacteria,2U9RH@28211|Alphaproteobacteria,2KIQF@204458|Caulobacterales	204458|Caulobacterales	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_6873876_1	344747.PM8797T_08574	3.851e-99	342.0	COG4225@1|root,COG4225@2|Bacteria,2IZFK@203682|Planctomycetes	203682|Planctomycetes	S	unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
TLS2_k127_6873876_0	1340493.JNIF01000003_gene4600	7.854e-157	509.0	COG1629@1|root,COG4771@2|Bacteria,3Y66U@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6873876_4	2074.JNYD01000002_gene5788	6.383e-15	88.0	COG5012@1|root,COG5012@2|Bacteria,2IEGQ@201174|Actinobacteria	201174|Actinobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
TLS2_k127_6873962_0	234267.Acid_0769	5.101e-197	622.0	COG1111@1|root,COG1205@1|root,COG1111@2|Bacteria,COG1205@2|Bacteria,3Y61D@57723|Acidobacteria	57723|Acidobacteria	L	Domain of unknown function (DUF1998)	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
TLS2_k127_6873962_1	234267.Acid_1535	1.879e-161	519.0	COG0739@1|root,COG0739@2|Bacteria,3Y3GS@57723|Acidobacteria	57723|Acidobacteria	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_6879979_3	395961.Cyan7425_0692	7.382e-69	243.0	COG0500@1|root,COG2226@2|Bacteria,1G0WT@1117|Cyanobacteria	1117|Cyanobacteria	Q	PFAM O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
TLS2_k127_6879979_1	927677.ALVU02000001_gene1997	1.809e-87	301.0	COG0500@1|root,COG2226@2|Bacteria,1G0WT@1117|Cyanobacteria	1117|Cyanobacteria	Q	PFAM O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
TLS2_k127_6879979_0	1267534.KB906754_gene3169	1.356e-131	445.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria	2|Bacteria	K	Transcriptional regulator	aglU	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase,Trans_reg_C,WD40
TLS2_k127_6879979_4	656024.FsymDg_1983	1.866e-05	48.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	vapC	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
TLS2_k127_6879979_2	697282.Mettu_2223	9.796e-83	281.0	28NKC@1|root,2ZBM7@2|Bacteria,1MWMY@1224|Proteobacteria,1S4WY@1236|Gammaproteobacteria,1XGAR@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6881411_0	313612.L8106_29995	5.79e-25	119.0	29WXV@1|root,30IK0@2|Bacteria,1G9AN@1117|Cyanobacteria	1117|Cyanobacteria	S	TniQ	-	-	-	-	-	-	-	-	-	-	-	-	TniQ
TLS2_k127_6881411_1	1278309.KB907100_gene2284	1.344e-24	111.0	COG2842@1|root,COG2842@2|Bacteria,1R9BD@1224|Proteobacteria,1SCZF@1236|Gammaproteobacteria,1XMSQ@135619|Oceanospirillales	135619|Oceanospirillales	S	Bacterial TniB protein	-	-	-	-	-	-	-	-	-	-	-	-	TniB
TLS2_k127_6889243_1	1127673.GLIP_1996	3.382e-158	514.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtB	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
TLS2_k127_6889243_7	1123377.AUIV01000002_gene1095	2.842e-41	168.0	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,1RN0S@1236|Gammaproteobacteria,1X433@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
TLS2_k127_6889243_5	1267535.KB906767_gene1564	3.361e-110	364.0	COG1560@1|root,COG1560@2|Bacteria,3Y2RW@57723|Acidobacteria,2JIMS@204432|Acidobacteriia	204432|Acidobacteriia	M	lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
TLS2_k127_6889243_0	1267535.KB906767_gene1561	9.07e-179	565.0	COG0482@1|root,COG0482@2|Bacteria,3Y2JX@57723|Acidobacteria,2JHKV@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TLS2_k127_6889243_3	1267535.KB906767_gene1560	4.057e-120	399.0	COG1104@1|root,COG1104@2|Bacteria,3Y389@57723|Acidobacteria,2JIPA@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM aminotransferase class V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS2_k127_6889243_6	234267.Acid_0601	4.356e-103	342.0	COG1912@1|root,COG1912@2|Bacteria,3Y50E@57723|Acidobacteria	57723|Acidobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
TLS2_k127_6889243_2	452637.Oter_1814	3.411e-122	425.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_6889243_8	234267.Acid_0689	2.151e-32	136.0	COG3093@1|root,COG3093@2|Bacteria,3Y5MG@57723|Acidobacteria	2|Bacteria	K	TIGRFAM Addiction module antidote protein, HigA	vapL	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3,HTH_31
TLS2_k127_6889243_4	1123278.KB893616_gene3402	7.323e-115	384.0	COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,47T8D@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_6889624_3	1089551.KE386572_gene2886	1.102e-22	102.0	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2U5HG@28211|Alphaproteobacteria,4BQ7M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
TLS2_k127_6889624_0	234267.Acid_1738	2.068e-187	597.0	COG2373@1|root,COG2373@2|Bacteria,3Y6DW@57723|Acidobacteria	57723|Acidobacteria	S	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase
TLS2_k127_6889624_1	926566.Terro_0847	5.974e-62	218.0	COG1403@1|root,COG1403@2|Bacteria,3Y500@57723|Acidobacteria,2JJK7@204432|Acidobacteriia	204432|Acidobacteriia	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH
TLS2_k127_6889624_2	234267.Acid_7842	3.584e-58	208.0	COG1273@1|root,COG1273@2|Bacteria,3Y4E7@57723|Acidobacteria	57723|Acidobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	-	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
TLS2_k127_6891721_2	1048983.EL17_22435	1.795e-17	92.0	COG1082@1|root,COG2152@1|root,COG1082@2|Bacteria,COG2152@2|Bacteria,4NGDZ@976|Bacteroidetes,47KUI@768503|Cytophagia	976|Bacteroidetes	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_6891721_1	595460.RRSWK_04700	5.261e-100	342.0	COG0673@1|root,COG0673@2|Bacteria,2IXRR@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_6891721_0	1178825.ALIH01000004_gene2795	2.025e-120	396.0	COG0673@1|root,COG0673@2|Bacteria,4NJEP@976|Bacteroidetes,1I3KI@117743|Flavobacteriia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_6895251_0	290317.Cpha266_1664	5.566e-142	462.0	COG3464@1|root,COG3464@2|Bacteria,1FESP@1090|Chlorobi	1090|Chlorobi	L	PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
TLS2_k127_69_2	483219.LILAB_10280	7.689e-55	203.0	COG0006@1|root,COG0006@2|Bacteria,1MVHD@1224|Proteobacteria	1224|Proteobacteria	E	Xaa-Pro aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
TLS2_k127_69_0	297246.lpp2312	2.057e-120	398.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,1RPD0@1236|Gammaproteobacteria,1JDB3@118969|Legionellales	118969|Legionellales	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_69_3	1117958.PE143B_0104010	4.866e-14	77.0	2EC13@1|root,3360B@2|Bacteria,1NG6Q@1224|Proteobacteria,1SEDP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_69_1	323261.Noc_0627	5.563e-103	344.0	COG0582@1|root,COG0582@2|Bacteria,1MXUB@1224|Proteobacteria,1RPVR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Integrase_1,Phage_int_SAM_2
TLS2_k127_6906376_0	426117.M446_3958	9.997e-41	162.0	COG3861@1|root,COG3861@2|Bacteria,1QVGH@1224|Proteobacteria,2TWFI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6906376_1	1123368.AUIS01000006_gene561	4.798e-17	87.0	COG3861@1|root,COG3861@2|Bacteria,1NHME@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF2382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382
TLS2_k127_6906376_2	366394.Smed_5281	1.959e-16	81.0	COG0702@1|root,COG0702@2|Bacteria,1N8V3@1224|Proteobacteria,2TYI8@28211|Alphaproteobacteria,4BD9R@82115|Rhizobiaceae	28211|Alphaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
TLS2_k127_6906376_3	1297569.MESS2_1150004	4.617e-16	83.0	COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2TRAK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator	MA20_42410	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_6907309_1	1267534.KB906756_gene98	1.135e-216	690.0	COG0308@1|root,COG0457@1|root,COG0308@2|Bacteria,COG0457@2|Bacteria,3Y6C4@57723|Acidobacteria	57723|Acidobacteria	E	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8
TLS2_k127_6907309_4	926566.Terro_0570	1.318e-89	304.0	COG4249@1|root,COG4249@2|Bacteria,3Y6DQ@57723|Acidobacteria,2JMKY@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6907309_0	234267.Acid_6438	4.316e-260	821.0	COG1572@1|root,COG2304@1|root,COG5426@1|root,COG1572@2|Bacteria,COG2304@2|Bacteria,COG5426@2|Bacteria,3Y6YC@57723|Acidobacteria	57723|Acidobacteria	S	Putative glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
TLS2_k127_6907309_3	1340493.JNIF01000003_gene4787	3.37e-110	362.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y62R@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
TLS2_k127_6907309_5	1340493.JNIF01000003_gene3560	7.305e-53	203.0	COG0657@1|root,COG0657@2|Bacteria,3Y88B@57723|Acidobacteria	57723|Acidobacteria	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS2_k127_6907309_2	234267.Acid_2700	1.79e-113	370.0	COG1028@1|root,COG1028@2|Bacteria,3Y6NJ@57723|Acidobacteria	57723|Acidobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_6907309_6	1227484.C471_15997	5.698e-11	71.0	COG1651@1|root,arCOG02868@2157|Archaea,2XWXT@28890|Euryarchaeota,23V6J@183963|Halobacteria	183963|Halobacteria	O	COG1651 Protein-disulfide isomerase	bdbD	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
TLS2_k127_6909909_1	1382359.JIAL01000001_gene1553	1.631e-63	222.0	COG0499@1|root,COG0499@2|Bacteria,3Y2J2@57723|Acidobacteria,2JIFV@204432|Acidobacteriia	204432|Acidobacteriia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS2_k127_6909909_0	234267.Acid_2025	8.029e-148	481.0	COG0544@1|root,COG0544@2|Bacteria,3Y45D@57723|Acidobacteria	57723|Acidobacteria	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
TLS2_k127_6909909_3	489825.LYNGBM3L_67310	2.376e-11	66.0	COG1598@1|root,COG1598@2|Bacteria,1G9Q6@1117|Cyanobacteria,1HG3X@1150|Oscillatoriales	1117|Cyanobacteria	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
TLS2_k127_6909909_2	1173028.ANKO01000127_gene4158	1.122e-13	73.0	COG1724@1|root,COG1724@2|Bacteria,1G9GU@1117|Cyanobacteria,1HDUJ@1150|Oscillatoriales	1117|Cyanobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
TLS2_k127_6910448_0	1340493.JNIF01000003_gene3527	3.749e-303	940.0	COG0441@1|root,COG0441@2|Bacteria,3Y2V0@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
TLS2_k127_6910448_8	234267.Acid_4520	1.384e-47	177.0	COG1335@1|root,COG1335@2|Bacteria,3Y7ZP@57723|Acidobacteria	57723|Acidobacteria	Q	Isochorismatase family	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
TLS2_k127_6910448_1	1267535.KB906767_gene2961	2.599e-155	503.0	COG1488@1|root,COG1488@2|Bacteria,3Y6U3@57723|Acidobacteria	57723|Acidobacteria	H	Nicotinate phosphoribosyltransferase (NAPRTase) family	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
TLS2_k127_6910448_6	234267.Acid_4518	1.423e-125	416.0	2ANCT@1|root,31DBC@2|Bacteria,3Y69A@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
TLS2_k127_6910448_3	234267.Acid_4517	4.747e-146	475.0	COG3225@1|root,COG3225@2|Bacteria,3Y6WR@57723|Acidobacteria	57723|Acidobacteria	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
TLS2_k127_6910448_7	1382359.JIAL01000001_gene1268	3.045e-98	329.0	COG1277@1|root,COG1277@2|Bacteria,3Y6D0@57723|Acidobacteria	57723|Acidobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS2_k127_6910448_2	234267.Acid_4515	4.93e-150	480.0	COG1131@1|root,COG1131@2|Bacteria,3Y6FZ@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6910448_5	1267535.KB906767_gene4946	1.837e-139	451.0	COG0167@1|root,COG0167@2|Bacteria,3Y2K1@57723|Acidobacteria,2JHXE@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TLS2_k127_6910448_4	1267535.KB906767_gene4947	1.175e-142	461.0	COG0076@1|root,COG0076@2|Bacteria,3Y2SW@57723|Acidobacteria,2JMFG@204432|Acidobacteriia	204432|Acidobacteriia	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS2_k127_6913087_0	1123278.KB893565_gene3538	4.212e-207	676.0	COG2866@1|root,COG2866@2|Bacteria,4NF3D@976|Bacteroidetes,47UEQ@768503|Cytophagia	976|Bacteroidetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS2_k127_6913087_2	1267535.KB906767_gene5096	2.316e-147	473.0	COG0388@1|root,COG0388@2|Bacteria,3Y2T9@57723|Acidobacteria,2JI2H@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
TLS2_k127_6913087_1	1267535.KB906767_gene5095	2.112e-153	492.0	COG2957@1|root,COG2957@2|Bacteria,3Y2W5@57723|Acidobacteria,2JIKF@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the agmatine deiminase family	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
TLS2_k127_6918824_0	509191.AEDB02000049_gene4422	1.46e-114	397.0	COG0457@1|root,COG0457@2|Bacteria,1UKT7@1239|Firmicutes,25G32@186801|Clostridia	186801|Clostridia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6918824_1	234267.Acid_6548	0.0003959	49.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_6919923_2	234267.Acid_1304	9.579e-44	168.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,3Y3SU@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_6919923_0	1122621.ATZA01000011_gene357	2.716e-174	561.0	COG0492@1|root,COG0492@2|Bacteria,4PKM3@976|Bacteroidetes	976|Bacteroidetes	O	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_6919923_1	1340493.JNIF01000004_gene463	2.011e-131	426.0	COG1995@1|root,COG1995@2|Bacteria,3Y37Q@57723|Acidobacteria	57723|Acidobacteria	H	Pyridoxal phosphate biosynthetic protein PdxA	-	-	1.1.1.408,1.1.1.409	ko:K22024	-	-	-	-	ko00000,ko01000	-	-	-	PdxA
TLS2_k127_6924925_0	340099.Teth39_0432	3.329e-146	476.0	COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,42FA0@68295|Thermoanaerobacterales	186801|Clostridia	E	amino acid carrier protein	agcS	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
TLS2_k127_6924925_1	1121035.AUCH01000002_gene1569	7.517e-76	265.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria,2KUNX@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,Response_reg
TLS2_k127_6926658_0	107636.JQNK01000007_gene4528	9.627e-164	533.0	COG0642@1|root,COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TWP9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	2.1.1.80,3.1.1.61	ko:K00575,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,GerE,HATPase_c,HisKA,PAS_10,Response_reg
TLS2_k127_6926658_1	933262.AXAM01000002_gene504	6.172e-71	259.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria,2MI6A@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
TLS2_k127_6926658_2	234267.Acid_1962	9.737e-23	100.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
TLS2_k127_6935600_0	234267.Acid_5361	7.156e-90	305.0	COG3910@1|root,COG3910@2|Bacteria	2|Bacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,AAA_21,AAA_23
TLS2_k127_6935600_1	502025.Hoch_0149	8.183e-35	139.0	COG1186@1|root,COG1186@2|Bacteria,1ND5C@1224|Proteobacteria,430VS@68525|delta/epsilon subdivisions,2WW3U@28221|Deltaproteobacteria,2Z2GT@29|Myxococcales	28221|Deltaproteobacteria	J	PFAM Class I peptide chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
TLS2_k127_6943821_0	234267.Acid_5624	1.03e-140	456.0	COG0589@1|root,COG1914@1|root,COG0589@2|Bacteria,COG1914@2|Bacteria,3Y2X1@57723|Acidobacteria	57723|Acidobacteria	P	PFAM natural resistance-associated macrophage protein	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp,Usp
TLS2_k127_6943821_1	1340493.JNIF01000004_gene178	3.867e-96	333.0	COG5549@1|root,COG5549@2|Bacteria	2|Bacteria	O	protein import	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10,Reprolysin_3
TLS2_k127_6945342_4	1184609.KILIM_092_00110	5.577e-17	83.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_6945342_1	595460.RRSWK_01232	1.11e-23	103.0	COG1321@1|root,COG1321@2|Bacteria	2|Bacteria	K	iron dependent repressor	ideR	-	3.4.21.88	ko:K01356,ko:K03709	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03000,ko03400	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA,LexA_DNA_bind
TLS2_k127_6945342_0	240015.ACP_0134	5.793e-28	117.0	COG1487@1|root,COG1487@2|Bacteria,3Y5X8@57723|Acidobacteria,2JK5Q@204432|Acidobacteriia	204432|Acidobacteriia	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
TLS2_k127_6945342_2	240015.ACP_0135	6.039e-23	104.0	COG4456@1|root,COG4456@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K18829	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
TLS2_k127_6945342_3	398578.Daci_0772	8.403e-23	108.0	COG3055@1|root,COG3055@2|Bacteria,1R00B@1224|Proteobacteria,2WC1K@28216|Betaproteobacteria,4AIQG@80864|Comamonadaceae	28216|Betaproteobacteria	S	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6949523_0	1340493.JNIF01000003_gene2650	6.458e-152	505.0	COG1629@1|root,COG4771@2|Bacteria,3Y980@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6949523_11	234267.Acid_5463	7.078e-30	133.0	COG2318@1|root,COG2318@2|Bacteria,3Y7GV@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_6949523_4	1340493.JNIF01000003_gene4393	5.648e-80	281.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_6949523_10	1267533.KB906735_gene5002	1.957e-30	124.0	COG1225@1|root,COG1225@2|Bacteria,3Y8D4@57723|Acidobacteria,2JNH4@204432|Acidobacteriia	204432|Acidobacteriia	O	Iodothyronine deiodinase	-	-	-	-	-	-	-	-	-	-	-	-	T4_deiodinase
TLS2_k127_6949523_13	204669.Acid345_1676	2.849e-20	97.0	2FJ4P@1|root,34AUY@2|Bacteria,3Y8PT@57723|Acidobacteria,2JNJ3@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6949523_5	234267.Acid_1717	8.997e-80	271.0	COG0688@1|root,COG0688@2|Bacteria,3Y4AZ@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
TLS2_k127_6949523_3	1340493.JNIF01000003_gene2300	2.725e-104	348.0	COG1183@1|root,COG1183@2|Bacteria,3Y3I7@57723|Acidobacteria	57723|Acidobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_6949523_6	234267.Acid_1719	1.877e-78	277.0	COG0136@1|root,COG0136@2|Bacteria,3Y395@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Semialdehyde dehydrogenase	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_6949523_7	1340493.JNIF01000003_gene2302	2.594e-48	179.0	COG2980@1|root,COG2980@2|Bacteria,3Y4V4@57723|Acidobacteria	57723|Acidobacteria	M	Lipopolysaccharide-assembly	-	-	-	-	-	-	-	-	-	-	-	-	LptE
TLS2_k127_6949523_2	1267535.KB906767_gene3610	4.691e-120	396.0	COG1466@1|root,COG1466@2|Bacteria,3Y2XE@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
TLS2_k127_6949523_12	234267.Acid_1723	1.114e-21	96.0	COG0268@1|root,COG0268@2|Bacteria,3Y5CZ@57723|Acidobacteria	57723|Acidobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
TLS2_k127_6949523_1	497964.CfE428DRAFT_4945	2.163e-121	405.0	COG1541@1|root,COG1541@2|Bacteria,46SVW@74201|Verrucomicrobia	74201|Verrucomicrobia	H	AMP-binding enzyme C-terminal domain	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
TLS2_k127_6949523_8	497964.CfE428DRAFT_4947	3.41e-43	162.0	COG0824@1|root,COG0824@2|Bacteria,46VXK@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
TLS2_k127_6949523_9	497964.CfE428DRAFT_5041	9.164e-37	142.0	COG0644@1|root,COG0644@2|Bacteria,46U5W@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
TLS2_k127_6956440_1	861299.J421_1301	2.461e-166	533.0	COG0151@1|root,COG0151@2|Bacteria	2|Bacteria	F	phosphoribosylamine-glycine ligase activity	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
TLS2_k127_6956440_0	1267535.KB906767_gene2631	7.597e-279	860.0	COG0174@1|root,COG0174@2|Bacteria,3Y2P8@57723|Acidobacteria,2JHXX@204432|Acidobacteriia	204432|Acidobacteriia	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS2_k127_6956440_3	1267535.KB906767_gene2482	4.218e-29	120.0	COG2154@1|root,COG2154@2|Bacteria,3Y8RH@57723|Acidobacteria	57723|Acidobacteria	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
TLS2_k127_6956440_2	234267.Acid_3631	3.841e-148	479.0	COG1680@1|root,COG3876@1|root,COG1680@2|Bacteria,COG3876@2|Bacteria,3Y2UC@57723|Acidobacteria	57723|Acidobacteria	V	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343,SSF
TLS2_k127_69758_3	1463825.JNXC01000022_gene532	1.536e-29	124.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
TLS2_k127_69758_2	1218084.BBJK01000165_gene7778	1.419e-31	131.0	COG0454@1|root,COG0456@2|Bacteria,1N8A4@1224|Proteobacteria,2VWFS@28216|Betaproteobacteria,1K3VD@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_69758_0	278963.ATWD01000001_gene3037	3.573e-83	291.0	COG4188@1|root,COG4188@2|Bacteria,3Y4JH@57723|Acidobacteria,2JJ88@204432|Acidobacteriia	204432|Acidobacteriia	S	Platelet-activating factor acetylhydrolase, isoform II	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_69758_1	595537.Varpa_2208	8.282e-63	219.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2VQ5D@28216|Betaproteobacteria,4ADG2@80864|Comamonadaceae	28216|Betaproteobacteria	J	endoribonuclease L-PSP	tdcF2	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
TLS2_k127_69758_4	926549.KI421517_gene821	1.398e-22	100.0	COG0384@1|root,COG0384@2|Bacteria,4NMWV@976|Bacteroidetes,47PEQ@768503|Cytophagia	976|Bacteroidetes	S	phenazine biosynthesis protein PhzF family	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
TLS2_k127_6980510_3	56107.Cylst_1983	5.534e-18	86.0	COG3668@1|root,COG3668@2|Bacteria,1G8WD@1117|Cyanobacteria,1HNXJ@1161|Nostocales	1117|Cyanobacteria	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
TLS2_k127_6980510_1	977880.pRALTA_0112	9.168e-51	182.0	COG5652@1|root,COG5652@2|Bacteria,1RDK4@1224|Proteobacteria,2VSI8@28216|Betaproteobacteria,1KB4F@119060|Burkholderiaceae	28216|Betaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6980510_0	631362.Thi970DRAFT_03403	1.485e-52	188.0	COG4190@1|root,COG4190@2|Bacteria,1RDM2@1224|Proteobacteria,1SA4D@1236|Gammaproteobacteria,1X1AD@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6980510_2	1255043.TVNIR_2332	2.115e-33	130.0	2C5EY@1|root,32YQJ@2|Bacteria,1N8K7@1224|Proteobacteria,1SDU6@1236|Gammaproteobacteria,1X19C@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
TLS2_k127_698477_5	1267535.KB906767_gene3460	8.941e-60	210.0	COG1721@1|root,COG1721@2|Bacteria,3Y6DV@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_698477_2	1267535.KB906767_gene3461	4.176e-152	486.0	COG0714@1|root,COG0714@2|Bacteria,3Y4G8@57723|Acidobacteria	57723|Acidobacteria	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_698477_8	765420.OSCT_0136	1.535e-16	93.0	COG4924@1|root,COG4924@2|Bacteria,2GAPK@200795|Chloroflexi,376YN@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function C-terminus (DUF2399)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2220
TLS2_k127_698477_4	1121430.JMLG01000002_gene1100	2.608e-140	488.0	COG4913@1|root,COG4913@2|Bacteria,1TPVZ@1239|Firmicutes,2491E@186801|Clostridia,2630X@186807|Peptococcaceae	186801|Clostridia	S	DNA replication and repair protein RecF	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SMC_hinge,SbcCD_C
TLS2_k127_698477_9	1089553.Tph_c04410	6.949e-16	85.0	2A92C@1|root,30Y6D@2|Bacteria,1V59Y@1239|Firmicutes	1239|Firmicutes	S	Domain of unknown function (DUF4194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4194
TLS2_k127_698477_6	760568.Desku_0319	1.623e-31	140.0	28JJB@1|root,2Z9CE@2|Bacteria,1U6BP@1239|Firmicutes,24B0T@186801|Clostridia,261SW@186807|Peptococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_698477_3	240015.ACP_0319	1.816e-149	478.0	COG0667@1|root,COG0667@2|Bacteria,3Y35T@57723|Acidobacteria,2JK73@204432|Acidobacteriia	204432|Acidobacteriia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_698477_7	1089550.ATTH01000001_gene2203	3.582e-22	109.0	COG3746@1|root,COG3746@2|Bacteria,4PEW5@976|Bacteroidetes,1FJQE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Phosphate-selective porin O and P	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
TLS2_k127_698477_1	1340493.JNIF01000003_gene3755	2.341e-186	595.0	COG2960@1|root,COG2960@2|Bacteria	2|Bacteria	M	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
TLS2_k127_698477_0	1340493.JNIF01000003_gene3756	1.553e-220	700.0	COG0551@1|root,COG2010@1|root,COG0551@2|Bacteria,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5
TLS2_k127_698477_11	394221.Mmar10_0843	1.204e-06	59.0	COG2940@1|root,COG2940@2|Bacteria,1N3VM@1224|Proteobacteria,2UDY0@28211|Alphaproteobacteria,43YPC@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
TLS2_k127_6989904_5	178901.AmDm5_1977	3.583e-06	49.0	COG0739@1|root,COG0739@2|Bacteria,1N6IQ@1224|Proteobacteria,2UNKJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_6989904_3	1207058.L53_07505	4.103e-78	268.0	arCOG07533@1|root,3167U@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
TLS2_k127_6989904_1	1207058.L53_07510	2.385e-98	327.0	COG1309@1|root,COG1309@2|Bacteria,1PJ6Q@1224|Proteobacteria,2V9MT@28211|Alphaproteobacteria,440JY@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_6989904_2	1265503.KB905165_gene1138	2.434e-81	286.0	COG1680@1|root,COG1680@2|Bacteria,1RGG3@1224|Proteobacteria,1S05K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_6989904_4	266265.Bxe_C0542	2.714e-66	234.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,2VH1V@28216|Betaproteobacteria,1K3TN@119060|Burkholderiaceae	28216|Betaproteobacteria	K	CRP FNR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_6989904_0	1123073.KB899241_gene2409	4.091e-113	372.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,1RP0B@1236|Gammaproteobacteria,1X5M5@135614|Xanthomonadales	135614|Xanthomonadales	T	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_6990145_6	926560.KE387027_gene263	5.77e-84	286.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	ko:K22135	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_6990145_10	1123284.KB899042_gene1350	1.053e-11	73.0	COG3409@1|root,COG3584@1|root,COG3409@2|Bacteria,COG3584@2|Bacteria,1TTIK@1239|Firmicutes,4HC79@91061|Bacilli,26P6V@186821|Sporolactobacillaceae	91061|Bacilli	M	3D domain	yabE	-	-	ko:K02424	ko02010,map02010	M00234	-	-	ko00000,ko00001,ko00002,ko02000,ko02035	3.A.1.3.10,3.A.1.3.14	-	-	3D,SH3_3
TLS2_k127_6990145_4	234267.Acid_0692	7.88e-137	441.0	COG0714@1|root,COG0714@2|Bacteria,3Y4G8@57723|Acidobacteria	57723|Acidobacteria	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_6990145_2	234267.Acid_0691	3.334e-163	520.0	COG0012@1|root,COG0012@2|Bacteria,3Y3D9@57723|Acidobacteria	57723|Acidobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
TLS2_k127_6990145_3	234267.Acid_1502	3.629e-142	469.0	COG0815@1|root,COG0815@2|Bacteria,3Y4FZ@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
TLS2_k127_6990145_5	234267.Acid_1501	7.581e-132	426.0	COG0320@1|root,COG0320@2|Bacteria,3Y6DY@57723|Acidobacteria	57723|Acidobacteria	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
TLS2_k127_6990145_9	1340493.JNIF01000003_gene4333	5.335e-23	106.0	COG3087@1|root,COG3087@2|Bacteria,3Y4WI@57723|Acidobacteria	57723|Acidobacteria	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
TLS2_k127_6990145_8	1303518.CCALI_00007	4.697e-26	111.0	COG3011@1|root,COG3011@2|Bacteria	2|Bacteria	CH	Protein conserved in bacteria	yuxK	-	-	-	-	-	-	-	-	-	-	-	DUF393
TLS2_k127_6990145_1	925409.KI911562_gene1525	1.679e-168	545.0	COG1232@1|root,COG1232@2|Bacteria,4NJNP@976|Bacteroidetes	976|Bacteroidetes	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS2_k127_6990145_7	102232.GLO73106DRAFT_00011930	6.07e-80	283.0	COG1216@1|root,COG1216@2|Bacteria,1G0PG@1117|Cyanobacteria	1117|Cyanobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_6990145_0	234267.Acid_2208	4.453e-227	714.0	COG1239@1|root,COG1239@2|Bacteria,3Y3FM@57723|Acidobacteria	57723|Acidobacteria	H	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Sigma54_activat
TLS2_k127_6990145_11	234267.Acid_2209	1.375e-10	61.0	COG4867@1|root,COG4867@2|Bacteria,3Y2VU@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA_2
TLS2_k127_6992533_2	566466.NOR53_1067	1.244e-07	54.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1S13F@1236|Gammaproteobacteria,1JB3R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16,TPR_8
TLS2_k127_6992533_1	1453501.JELR01000001_gene3236	2.47e-13	82.0	2C612@1|root,32RGH@2|Bacteria,1RGYZ@1224|Proteobacteria,1S8MM@1236|Gammaproteobacteria,46BBZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6992533_0	522306.CAP2UW1_2634	8.577e-22	100.0	COG5608@1|root,COG5608@2|Bacteria,1N6YX@1224|Proteobacteria,2WFZ1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	SMART Water Stress and Hypersensitive response	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
TLS2_k127_7007910_0	1403819.BATR01000052_gene1599	2.243e-121	403.0	COG3119@1|root,COG3119@2|Bacteria,46ZIZ@74201|Verrucomicrobia,2IV4W@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_7007910_1	1340493.JNIF01000003_gene2575	6.716e-100	338.0	COG1629@1|root,COG1629@2|Bacteria,3Y3KT@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_7008613_0	266779.Meso_2421	8.736e-232	733.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2VF2F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TLS2_k127_7008613_1	366394.Smed_6272	1.378e-117	386.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U2G6@28211|Alphaproteobacteria,4BFQW@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_7008613_3	397945.Aave_1292	8.724e-39	150.0	COG0071@1|root,COG0071@2|Bacteria,1N1RF@1224|Proteobacteria,2VT18@28216|Betaproteobacteria,4AEGT@80864|Comamonadaceae	28216|Betaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS2_k127_7008613_2	1123229.AUBC01000011_gene2295	4.032e-71	253.0	COG3284@1|root,COG3920@1|root,COG3284@2|Bacteria,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2TX95@28211|Alphaproteobacteria,3K6TG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS_3,PAS_4,PAS_9
TLS2_k127_7008613_4	1057002.KB905370_gene3505	4.646e-34	134.0	COG0596@1|root,COG0596@2|Bacteria,1Q47F@1224|Proteobacteria,2U3WB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_7008613_5	318586.Pden_0106	5.384e-30	120.0	COG1961@1|root,COG1961@2|Bacteria,1MV0C@1224|Proteobacteria,2TTJT@28211|Alphaproteobacteria,2PU7A@265|Paracoccus	28211|Alphaproteobacteria	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_7035539_5	1267535.KB906767_gene4668	2.933e-90	303.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	GlcNAc,Glycos_transf_2
TLS2_k127_7035539_4	234267.Acid_7548	7.119e-106	353.0	COG1453@1|root,COG1453@2|Bacteria,3Y6QH@57723|Acidobacteria	57723|Acidobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_7035539_0	1340493.JNIF01000004_gene889	1.246e-240	755.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_7035539_1	1340493.JNIF01000004_gene890	8.722e-235	746.0	COG2010@1|root,COG3695@1|root,COG2010@2|Bacteria,COG3695@2|Bacteria,3Y5FU@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Methylated-DNA- protein -cysteine S-methyltransferase, DNA binding	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
TLS2_k127_7035539_6	234267.Acid_4604	7.037e-32	144.0	COG1470@1|root,COG3291@1|root,COG1470@2|Bacteria,COG3291@2|Bacteria,3Y97Z@57723|Acidobacteria	57723|Acidobacteria	G	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
TLS2_k127_7035539_3	1340493.JNIF01000003_gene4382	1.586e-127	422.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_7035539_7	234267.Acid_4458	5.019e-22	104.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,Copper-bind,Cytochrom_C,Cytochrome_CBB3,DUF1573,Laminin_G_3,ThuA
TLS2_k127_7035539_2	1340493.JNIF01000004_gene854	4.912e-222	702.0	COG1629@1|root,COG4771@2|Bacteria,3Y6CE@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_7059793_1	196490.AUEZ01000026_gene1773	1.52e-71	252.0	COG0860@1|root,COG0860@2|Bacteria,1RJBG@1224|Proteobacteria,2TVMH@28211|Alphaproteobacteria,3JR6M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
TLS2_k127_7059793_0	1038859.AXAU01000030_gene6762	9.456e-221	693.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,3JVHX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
TLS2_k127_706074_5	1267534.KB906757_gene1040	1.947e-42	160.0	COG1680@1|root,COG1680@2|Bacteria,3Y889@57723|Acidobacteria,2JNBM@204432|Acidobacteriia	204432|Acidobacteriia	V	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_706074_1	234267.Acid_2130	4.021e-91	309.0	COG0657@1|root,COG0657@2|Bacteria,3Y4WR@57723|Acidobacteria	57723|Acidobacteria	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
TLS2_k127_706074_2	1123278.KB893511_gene1444	3.573e-83	279.0	COG0693@1|root,COG0693@2|Bacteria,4NQI1@976|Bacteroidetes,47NR0@768503|Cytophagia	976|Bacteroidetes	S	TIGRFAM intracellular protease, PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
TLS2_k127_706074_3	1210884.HG799467_gene13369	3.997e-57	211.0	COG2374@1|root,COG2374@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Big_3_5,LTD
TLS2_k127_706074_4	1267535.KB906767_gene5279	8.84e-45	173.0	2ADW4@1|root,313N4@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF4230)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4230
TLS2_k127_706074_0	234267.Acid_0453	4.503e-128	415.0	COG1132@1|root,COG1132@2|Bacteria,3Y2ZR@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane	-	-	-	ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
TLS2_k127_7066839_5	1340493.JNIF01000003_gene2101	9.603e-19	87.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	CMAS,MTS,Methyltransf_23,Methyltransf_25,Methyltransf_31
TLS2_k127_7066839_0	234267.Acid_4808	6.794e-156	497.0	COG0524@1|root,COG0524@2|Bacteria,3Y659@57723|Acidobacteria	57723|Acidobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.184	ko:K18478	-	-	R10970	RC00002,RC00017	ko00000,ko01000	-	-	-	PfkB
TLS2_k127_7066839_2	234267.Acid_4807	1.077e-92	308.0	COG0705@1|root,COG0705@2|Bacteria,3Y5A9@57723|Acidobacteria	57723|Acidobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS2_k127_7066839_3	1267535.KB906767_gene1497	8.717e-85	287.0	COG2120@1|root,COG2120@2|Bacteria,3Y3NP@57723|Acidobacteria,2JIEH@204432|Acidobacteriia	204432|Acidobacteriia	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_7066839_4	1123075.AUDP01000024_gene1090	9.093e-65	238.0	COG2159@1|root,COG2159@2|Bacteria,1UZI6@1239|Firmicutes,24EHD@186801|Clostridia,3WKR9@541000|Ruminococcaceae	186801|Clostridia	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_7066839_6	1123075.AUDP01000024_gene1090	1.828e-06	51.0	COG2159@1|root,COG2159@2|Bacteria,1UZI6@1239|Firmicutes,24EHD@186801|Clostridia,3WKR9@541000|Ruminococcaceae	186801|Clostridia	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_7066839_1	1479239.JQMU01000001_gene2550	1.06e-144	471.0	COG0659@1|root,COG0659@2|Bacteria,1MX8F@1224|Proteobacteria,2U0IJ@28211|Alphaproteobacteria,2K0EC@204457|Sphingomonadales	204457|Sphingomonadales	P	Transporter	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2,Sulfate_transp
TLS2_k127_7067890_0	251221.35214774	3.134e-70	255.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,TIG,VCBS
TLS2_k127_7075929_7	255470.cbdbA232	6.341e-20	98.0	COG2314@1|root,COG2314@2|Bacteria,2GAV8@200795|Chloroflexi,34DEZ@301297|Dehalococcoidia	301297|Dehalococcoidia	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2,zinc_ribbon_2
TLS2_k127_7075929_5	440512.C211_08744	5.318e-44	170.0	COG3727@1|root,COG3727@2|Bacteria,1RH1C@1224|Proteobacteria	1224|Proteobacteria	L	May nick specific sequences that contain T G mispairs resulting from m5C-deamination	vsr	-	-	ko:K07458	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF559,Vsr
TLS2_k127_7075929_8	1267535.KB906767_gene2205	1.512e-11	67.0	2ETRB@1|root,33M8W@2|Bacteria,3Y5ZS@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF465)	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
TLS2_k127_7075929_3	1340493.JNIF01000003_gene4631	1.572e-87	295.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_7075929_2	1340493.JNIF01000004_gene437	1.25e-92	310.0	COG0101@1|root,COG0101@2|Bacteria,3Y833@57723|Acidobacteria	57723|Acidobacteria	J	tRNA pseudouridine synthase	-	-	-	-	-	-	-	-	-	-	-	-	PseudoU_synth_1
TLS2_k127_7075929_6	404380.Gbem_3121	8.448e-43	160.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,42TZA@68525|delta/epsilon subdivisions,2WRHK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
TLS2_k127_7075929_1	234267.Acid_6491	3.23e-100	334.0	COG1187@1|root,COG1187@2|Bacteria,3Y3CQ@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_7075929_4	234267.Acid_6490	8.719e-83	284.0	COG1386@1|root,COG1386@2|Bacteria,3Y3E0@57723|Acidobacteria	57723|Acidobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
TLS2_k127_7075929_0	1267535.KB906767_gene5273	6.411e-101	335.0	COG1354@1|root,COG1354@2|Bacteria,3Y458@57723|Acidobacteria,2JIGP@204432|Acidobacteriia	204432|Acidobacteriia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
TLS2_k127_7078155_0	1267535.KB906767_gene2381	1.051e-96	329.0	COG1082@1|root,COG1082@2|Bacteria,3Y7VE@57723|Acidobacteria,2JN0J@204432|Acidobacteriia	204432|Acidobacteriia	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7078155_2	383372.Rcas_2754	1.949e-72	257.0	COG1940@1|root,COG1940@2|Bacteria,2G6I0@200795|Chloroflexi,375NG@32061|Chloroflexia	32061|Chloroflexia	GK	PFAM ROK family protein	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_7078155_1	575540.Isop_0756	2.169e-89	298.0	COG0274@1|root,COG0274@2|Bacteria,2IWY0@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS2_k127_7079554_0	234267.Acid_5783	1.199e-301	935.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_7079554_5	1408254.T458_23015	5.855e-20	104.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,4HB1C@91061|Bacilli,26QDY@186822|Paenibacillaceae	91061|Bacilli	K	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	yisV	-	-	ko:K18907	-	M00700,M00702	-	-	ko00000,ko00002,ko01504,ko03000	-	-	-	Aminotran_1_2,GntR
TLS2_k127_7079554_2	1219045.BV98_003146	9.819e-174	564.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,2K30V@204457|Sphingomonadales	204457|Sphingomonadales	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
TLS2_k127_7079554_3	1121904.ARBP01000019_gene2784	1.199e-100	341.0	COG3525@1|root,COG3525@2|Bacteria,4NGV2@976|Bacteroidetes,47TJT@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolase family 20, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_20
TLS2_k127_7079554_1	234267.Acid_3165	7.549e-188	604.0	COG2812@1|root,COG2812@2|Bacteria,3Y3C4@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
TLS2_k127_7079554_4	1267535.KB906767_gene4256	1.9e-38	145.0	COG0718@1|root,COG0718@2|Bacteria,3Y5CB@57723|Acidobacteria	57723|Acidobacteria	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
TLS2_k127_7081303_4	234267.Acid_3246	2.522e-134	432.0	COG0673@1|root,COG0673@2|Bacteria,3Y76D@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_7081303_1	861299.J421_6259	1.368e-227	724.0	COG0366@1|root,COG0366@2|Bacteria,1ZUGN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Cyclomaltodextrinase, N-terminal	-	-	3.2.1.135	ko:K21575	-	-	-	-	ko00000,ko01000	-	GH13	-	Alpha-amylase,Cyc-maltodext_N
TLS2_k127_7081303_13	1449357.JQLK01000001_gene1693	1.69e-13	74.0	2DSVR@1|root,33HKS@2|Bacteria,1WKIU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,RHH_3,RHH_4
TLS2_k127_7081303_12	477974.Daud_0415	2.553e-34	139.0	COG2402@1|root,COG2402@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_7081303_6	530564.Psta_2160	5.326e-93	314.0	COG1335@1|root,COG3391@1|root,COG3828@1|root,COG1335@2|Bacteria,COG3391@2|Bacteria,COG3828@2|Bacteria,2IX7K@203682|Planctomycetes	203682|Planctomycetes	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase,ThuA
TLS2_k127_7081303_7	234267.Acid_7665	1.543e-81	294.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_2,PSCyt2,PSD1
TLS2_k127_7081303_10	234267.Acid_7666	8.3e-54	208.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_7081303_11	330214.NIDE4175	8.384e-54	200.0	COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TLS2_k127_7081303_5	1340493.JNIF01000003_gene4597	1.245e-127	415.0	COG0329@1|root,COG0329@2|Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_7081303_3	1340493.JNIF01000003_gene4598	7.273e-138	453.0	COG2271@1|root,COG2271@2|Bacteria,3Y6U9@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_7081303_9	1340493.JNIF01000003_gene4599	3.86e-58	209.0	COG1802@1|root,COG1802@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_7081303_8	1123023.JIAI01000003_gene2551	1.013e-68	248.0	COG4948@1|root,COG4948@2|Bacteria,2H17U@201174|Actinobacteria,4E9ZY@85010|Pseudonocardiales	201174|Actinobacteria	M	Enolase C-terminal domain-like	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_7081303_2	1267535.KB906767_gene806	8.052e-156	507.0	COG1629@1|root,COG4771@2|Bacteria	1267535.KB906767_gene806|-	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7081303_0	1267535.KB906767_gene806	2.482e-231	733.0	COG1629@1|root,COG4771@2|Bacteria	1267535.KB906767_gene806|-	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7081303_14	234267.Acid_6102	5.458e-05	49.0	COG4974@1|root,COG4974@2|Bacteria,3Y68K@57723|Acidobacteria	57723|Acidobacteria	L	phage integrase domain protein SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
TLS2_k127_7110265_0	234267.Acid_3353	5.359e-243	760.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,3Y2I2@57723|Acidobacteria	57723|Acidobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
TLS2_k127_7110265_1	1267535.KB906767_gene5356	1.219e-149	481.0	COG1641@1|root,COG1641@2|Bacteria,3Y42R@57723|Acidobacteria,2JI6G@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function DUF111	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
TLS2_k127_7122302_1	1340493.JNIF01000003_gene4811	1.479e-118	390.0	COG0760@1|root,COG0760@2|Bacteria,3Y42Z@57723|Acidobacteria	57723|Acidobacteria	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N_3
TLS2_k127_7122302_3	1267535.KB906767_gene2266	7.755e-46	177.0	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_7122302_2	1267535.KB906767_gene2485	1.26e-102	343.0	COG0506@1|root,COG0506@2|Bacteria,3Y2G8@57723|Acidobacteria,2JHRI@204432|Acidobacteriia	204432|Acidobacteriia	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
TLS2_k127_7122302_0	234267.Acid_2834	9.122e-181	576.0	COG1236@1|root,COG1236@2|Bacteria,3Y6U0@57723|Acidobacteria	57723|Acidobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
TLS2_k127_7122302_4	1340493.JNIF01000004_gene73	5.027e-45	176.0	COG3712@1|root,COG3712@2|Bacteria,3Y5MB@57723|Acidobacteria	57723|Acidobacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	FecR
TLS2_k127_7122302_5	309801.trd_A0832	6.463e-09	58.0	COG2331@1|root,COG2331@2|Bacteria,2G7IB@200795|Chloroflexi	200795|Chloroflexi	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TLS2_k127_7123062_8	1340493.JNIF01000004_gene205	3.016e-55	205.0	COG0510@1|root,COG0510@2|Bacteria	2|Bacteria	M	ethanolamine kinase activity	strN	-	2.7.1.72,2.7.1.89	ko:K04343,ko:K07251,ko:K18844	ko00730,ko01100,map00730,map01100	M00766	R02134,R02225	RC00002,RC00017,RC00078	br01600,ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	APH,Choline_kinase
TLS2_k127_7123062_3	1449357.JQLK01000001_gene621	1.076e-126	419.0	COG0148@1|root,COG0148@2|Bacteria,1WIST@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TLS2_k127_7123062_7	234267.Acid_7192	1.318e-65	228.0	COG2940@1|root,COG2940@2|Bacteria,3Y7R1@57723|Acidobacteria	57723|Acidobacteria	S	SET domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
TLS2_k127_7123062_0	1340493.JNIF01000004_gene87	2.16e-159	507.0	COG0039@1|root,COG0039@2|Bacteria,3Y2PG@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
TLS2_k127_7123062_1	1210884.HG799462_gene9086	4.224e-133	452.0	COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_7123062_9	1192034.CAP_7774	2.393e-35	156.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase,cNMP_binding
TLS2_k127_7123062_2	404380.Gbem_3181	5.104e-127	430.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,43TPU@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,HAMP,HATPase_c,HisKA,Hpt,Response_reg
TLS2_k127_7123062_11	671143.DAMO_1265	1.623e-19	98.0	2E3CB@1|root,32YBM@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4154)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4154
TLS2_k127_7123062_5	671143.DAMO_1264	2.296e-114	392.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TLS2_k127_7123062_10	383372.Rcas_0816	2.543e-24	107.0	COG1917@1|root,COG1917@2|Bacteria,2G7C7@200795|Chloroflexi,377HW@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Cupin 2 conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7123062_4	1173024.KI912148_gene3638	1.685e-118	395.0	COG0668@1|root,COG0668@2|Bacteria,1GJ68@1117|Cyanobacteria,1JKW0@1189|Stigonemataceae	1117|Cyanobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
TLS2_k127_7123062_6	1340493.JNIF01000003_gene4604	6.605e-110	366.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	DUF3500
TLS2_k127_712507_2	234267.Acid_3183	2.951e-85	294.0	COG2316@1|root,COG2316@2|Bacteria,3Y4GI@57723|Acidobacteria	57723|Acidobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
TLS2_k127_712507_4	5465.ENH81027	8.729e-08	63.0	COG0457@1|root,KOG1126@2759|Eukaryota,38DG8@33154|Opisthokonta,3NW4C@4751|Fungi,3QK37@4890|Ascomycota,213C1@147550|Sordariomycetes,1EUG3@1028384|Glomerellales	4751|Fungi	D	Anaphase-promoting complex, cyclosome, subunit 3	CDC27	GO:0000070,GO:0000151,GO:0000152,GO:0000278,GO:0000280,GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005680,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006996,GO:0007049,GO:0007050,GO:0007059,GO:0007088,GO:0007346,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009896,GO:0009987,GO:0010498,GO:0010564,GO:0010638,GO:0010965,GO:0016043,GO:0016567,GO:0019538,GO:0019941,GO:0022402,GO:0030071,GO:0030163,GO:0031145,GO:0031331,GO:0031461,GO:0031974,GO:0031981,GO:0032270,GO:0032436,GO:0032446,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0034399,GO:0036211,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045732,GO:0045786,GO:0045787,GO:0045840,GO:0045842,GO:0045862,GO:0045930,GO:0045931,GO:0048285,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051247,GO:0051276,GO:0051603,GO:0051726,GO:0051781,GO:0051783,GO:0051785,GO:0051983,GO:0051984,GO:0062033,GO:0065007,GO:0070013,GO:0070647,GO:0071704,GO:0071840,GO:0071849,GO:0071850,GO:0071851,GO:0090068,GO:0097159,GO:0098813,GO:0140014,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901800,GO:1901970,GO:1901987,GO:1901989,GO:1901990,GO:1901992,GO:1902099,GO:1902101,GO:1902494,GO:1903047,GO:1903052,GO:1903364,GO:1905818,GO:1905820,GO:1990234,GO:2001252	-	ko:K03350	ko04110,ko04111,ko04113,ko04114,ko04120,ko04914,ko05166,map04110,map04111,map04113,map04114,map04120,map04914,map05166	M00389	-	-	ko00000,ko00001,ko00002,ko01009,ko03036,ko04121	-	-	-	ANAPC3,TPR_1,TPR_16,TPR_19,TPR_2,TPR_8
TLS2_k127_712507_1	234267.Acid_1589	6.815e-191	609.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_1589|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_712507_3	1267533.KB906743_gene818	2.353e-38	146.0	COG4274@1|root,COG4274@2|Bacteria	2|Bacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
TLS2_k127_712507_0	1340493.JNIF01000003_gene2517	0.0	1388.0	COG1629@1|root,COG4771@2|Bacteria,3Y3NM@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_7125328_1	1340493.JNIF01000003_gene4121	3.693e-148	475.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7125328_2	1238182.C882_1358	2.744e-38	150.0	COG0745@1|root,COG0745@2|Bacteria,1RD6H@1224|Proteobacteria,2U7MF@28211|Alphaproteobacteria,2JSI8@204441|Rhodospirillales	204441|Rhodospirillales	T	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_7125328_0	204669.Acid345_4515	3.184e-236	750.0	COG3590@1|root,COG3590@2|Bacteria,3Y31X@57723|Acidobacteria,2JIDI@204432|Acidobacteriia	204432|Acidobacteriia	O	peptidase	-	-	3.4.24.71	ko:K01415,ko:K07386	-	-	-	-	ko00000,ko01000,ko01002,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
TLS2_k127_7127868_1	366649.XFF4834R_chr10890	5.386e-08	58.0	COG1403@1|root,COG1403@2|Bacteria,1P5JC@1224|Proteobacteria	1224|Proteobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7127868_0	1385517.N800_01630	4.612e-242	773.0	COG1479@1|root,COG1479@2|Bacteria,1PM9H@1224|Proteobacteria,1TBRN@1236|Gammaproteobacteria,1XAQ3@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4268)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4268
TLS2_k127_7135417_1	234267.Acid_6148	6.472e-169	544.0	COG1921@1|root,COG1921@2|Bacteria,3Y6KN@57723|Acidobacteria	57723|Acidobacteria	E	L-seryl-tRNASec selenium transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7135417_4	314278.NB231_03220	2.025e-93	318.0	COG3021@1|root,COG3021@2|Bacteria,1MWFK@1224|Proteobacteria,1RPPZ@1236|Gammaproteobacteria,1X0D4@135613|Chromatiales	135613|Chromatiales	V	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_7135417_2	330214.NIDE1666	4.223e-121	403.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gpgS	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
TLS2_k127_7135417_7	1267535.KB906767_gene2295	5.702e-59	214.0	COG3769@1|root,COG3769@2|Bacteria	2|Bacteria	S	mannosylglycerate metabolic process	mpgP	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897	2.4.1.217,3.1.3.70	ko:K05947,ko:K07026	ko00051,map00051	-	R05768,R05790	RC00005,RC00017,RC00397,RC02748	ko00000,ko00001,ko01000,ko01003	-	-	-	Hydrolase_3
TLS2_k127_7135417_3	1267535.KB906767_gene2296	1.518e-120	403.0	COG4585@1|root,COG4585@2|Bacteria,3Y59R@57723|Acidobacteria	2|Bacteria	T	PFAM ATP-binding region, ATPase domain protein domain protein	-	-	2.7.13.3	ko:K07683	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF_2,HATPase_c,HisKA_3,PAS,PAS_9,Pkinase
TLS2_k127_7135417_5	1267535.KB906767_gene2297	2.101e-91	305.0	COG2197@1|root,COG2197@2|Bacteria,3Y6T2@57723|Acidobacteria,2JMQ5@204432|Acidobacteriia	204432|Acidobacteriia	T	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_7135417_8	1120934.KB894408_gene4684	4.294e-08	59.0	COG2261@1|root,COG2261@2|Bacteria,2GQR5@201174|Actinobacteria,4E75F@85010|Pseudonocardiales	201174|Actinobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS2_k127_7135417_0	1340493.JNIF01000003_gene4764	1.498e-285	890.0	arCOG10801@1|root,2Z9IC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7135417_6	1340493.JNIF01000003_gene3568	1.512e-77	267.0	COG3618@1|root,COG3618@2|Bacteria	2|Bacteria	H	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_713577_1	234267.Acid_1623	1.019e-27	119.0	COG2801@1|root,COG2801@2|Bacteria,3Y821@57723|Acidobacteria	57723|Acidobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
TLS2_k127_713577_0	94624.Bpet1409	9.386e-306	954.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2VK01@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Resolvase domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_713577_2	94624.Bpet1408	8.443e-18	84.0	COG3415@1|root,COG3415@2|Bacteria,1RKUV@1224|Proteobacteria,2WFVI@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29
TLS2_k127_7151421_1	1267535.KB906767_gene3543	2.967e-164	525.0	COG1459@1|root,COG1459@2|Bacteria,3Y2X8@57723|Acidobacteria,2JHIX@204432|Acidobacteriia	204432|Acidobacteriia	NU	PFAM Type II secretion system F domain	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
TLS2_k127_7151421_4	234267.Acid_7355	1.681e-47	173.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
TLS2_k127_7151421_2	1340493.JNIF01000003_gene1459	9.937e-105	355.0	COG1566@1|root,COG1566@2|Bacteria	2|Bacteria	V	PFAM secretion protein HlyD family protein	lprD	-	-	ko:K02005,ko:K02022	-	-	-	-	ko00000	-	-	-	HlyD_3
TLS2_k127_7151421_0	234267.Acid_2984	1.039e-191	606.0	COG4948@1|root,COG4948@2|Bacteria,3Y6CG@57723|Acidobacteria	2|Bacteria	M	PFAM Mandelate racemase muconate lactonizing enzyme, N-terminal domain protein	dgoD	GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034192,GO:0034194,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0071704,GO:0072329,GO:1901575	4.1.2.21,4.2.1.6	ko:K01631,ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R01064,R03033	RC00307,RC00435,RC00543	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b4478,iB21_1397.B21_03519,iBWG_1329.BWG_3382,iEC042_1314.EC042_4048,iEC55989_1330.EC55989_4161,iECBD_1354.ECBD_0011,iECB_1328.ECB_03575,iECDH10B_1368.ECDH10B_3878,iECDH1ME8569_1439.ECDH1ME8569_3579,iECD_1391.ECD_03575,iECIAI1_1343.ECIAI1_3870,iECO103_1326.ECO103_4466,iECO111_1330.ECO111_4519,iECSE_1348.ECSE_3978,iECUMN_1333.ECUMN_4223,iECW_1372.ECW_m3991,iEKO11_1354.EKO11_0011,iETEC_1333.ETEC_3982,iEcDH1_1363.EcDH1_0011,iEcE24377_1341.EcE24377A_4201,iEcSMS35_1347.EcSMS35_4057,iEcolC_1368.EcolC_0011,iJO1366.b4478,iWFL_1372.ECW_m3991,iY75_1357.Y75_RS18645	MR_MLE_C,MR_MLE_N
TLS2_k127_7151421_3	234267.Acid_2985	3.417e-60	216.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_7151595_2	471854.Dfer_2051	5.424e-142	464.0	COG3119@1|root,COG3119@2|Bacteria,4NFGI@976|Bacteroidetes,47ND1@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_7151595_7	234267.Acid_2537	1.008e-49	186.0	COG1595@1|root,COG1595@2|Bacteria,3Y5RY@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_7151595_5	234267.Acid_7894	1.078e-86	301.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
TLS2_k127_7151595_1	1340493.JNIF01000004_gene389	7.858e-168	557.0	COG1020@1|root,COG3882@1|root,COG1020@2|Bacteria,COG3882@2|Bacteria	2|Bacteria	Q	phosphopantetheine binding	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Condensation,Methyltransf_21,NAD_binding_4,PP-binding
TLS2_k127_7151595_3	234267.Acid_4715	3.839e-132	432.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	ko:K16703	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_7151595_0	234267.Acid_4714	1.899e-187	610.0	COG0438@1|root,COG3208@1|root,COG0438@2|Bacteria,COG3208@2|Bacteria,3Y55B@57723|Acidobacteria	57723|Acidobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Thioesterase
TLS2_k127_7151595_4	1340493.JNIF01000004_gene683	3.186e-105	357.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_7151595_6	234267.Acid_2039	1.126e-50	191.0	COG3176@1|root,COG3176@2|Bacteria,3Y95C@57723|Acidobacteria	57723|Acidobacteria	S	hemolysin	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_715391_3	1267535.KB906767_gene3386	1.06e-08	61.0	COG0673@1|root,COG0673@2|Bacteria,3Y39X@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_715391_5	234267.Acid_2313	2.226e-08	58.0	2EVWN@1|root,33PAB@2|Bacteria,3Y5UR@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_715391_1	580332.Slit_1318	2.409e-23	108.0	arCOG08935@1|root,32Z08@2|Bacteria,1R3HB@1224|Proteobacteria,2VYJZ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_715391_0	290397.Adeh_2142	9.459e-70	244.0	COG0252@1|root,COG0252@2|Bacteria,1RHAW@1224|Proteobacteria,42SNH@68525|delta/epsilon subdivisions,2WPQC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EJ	PFAM Asparaginase	aspG	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
TLS2_k127_715391_4	1183438.GKIL_2619	1.2e-08	60.0	2EMTX@1|root,33FG9@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07746	-	-	-	-	ko00000,ko02048	-	-	-	-
TLS2_k127_715391_2	1267534.KB906754_gene3531	8.128e-20	96.0	COG0627@1|root,COG0627@2|Bacteria,3Y63W@57723|Acidobacteria,2JMD1@204432|Acidobacteriia	204432|Acidobacteriia	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
TLS2_k127_7154648_1	234267.Acid_1304	6.443e-30	123.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,3Y3SU@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_7154648_0	1267535.KB906767_gene4229	7.8e-204	653.0	COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,3Y3X4@57723|Acidobacteria,2JING@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,HisKA_7TM,PAS,PAS_4
TLS2_k127_7165251_6	234267.Acid_3789	1.396e-30	126.0	COG2971@1|root,COG2971@2|Bacteria,3Y2J3@57723|Acidobacteria	57723|Acidobacteria	G	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
TLS2_k127_7165251_3	1267535.KB906767_gene976	7.398e-102	338.0	COG0177@1|root,COG0177@2|Bacteria,3Y3QD@57723|Acidobacteria,2JI6M@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TLS2_k127_7165251_2	234267.Acid_3783	2.171e-112	379.0	COG5010@1|root,COG5010@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K13486	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Acetyltransf_6,DUF1570,Response_reg,TPR_16,TPR_19
TLS2_k127_7165251_5	234267.Acid_5474	1.26e-38	153.0	COG4276@1|root,COG4276@2|Bacteria,3Y57N@57723|Acidobacteria	57723|Acidobacteria	S	Pfam Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_7165251_1	234267.Acid_6289	7.867e-238	746.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501,Sulfatase
TLS2_k127_7165251_0	1340493.JNIF01000003_gene1965	0.0	1128.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PSCyt1,PSCyt2,PSD1
TLS2_k127_7165251_4	1267535.KB906767_gene4476	1.21e-75	258.0	COG1082@1|root,COG1082@2|Bacteria,3Y69B@57723|Acidobacteria,2JM08@204432|Acidobacteriia	204432|Acidobacteriia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_7169648_3	1267535.KB906767_gene98	8.974e-54	197.0	COG0265@1|root,COG0265@2|Bacteria,3Y2WB@57723|Acidobacteria,2JI8Y@204432|Acidobacteriia	204432|Acidobacteriia	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_7169648_4	105559.Nwat_1693	1.222e-21	105.0	COG0071@1|root,COG0071@2|Bacteria,1NPJI@1224|Proteobacteria,1SRY5@1236|Gammaproteobacteria,1X21C@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS2_k127_7169648_0	1267535.KB906767_gene97	0.0	1056.0	COG0466@1|root,COG0466@2|Bacteria,3Y2QB@57723|Acidobacteria,2JHMJ@204432|Acidobacteriia	204432|Acidobacteriia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS2_k127_7169648_1	1340493.JNIF01000003_gene1663	3.744e-185	603.0	28MCK@1|root,2ZAQP@2|Bacteria,3Y41I@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7169648_2	234267.Acid_6726	1.1e-121	399.0	COG3005@1|root,COG3005@2|Bacteria,3Y4BJ@57723|Acidobacteria	57723|Acidobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
TLS2_k127_7174390_1	344747.PM8797T_13183	4.864e-179	584.0	COG2010@1|root,COG2010@2|Bacteria,2IYIY@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PSCyt1,PSCyt2,PSD1
TLS2_k127_7174390_0	344747.PM8797T_13188	4.32e-208	662.0	COG3119@1|root,COG3119@2|Bacteria,2IXXZ@203682|Planctomycetes	203682|Planctomycetes	P	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_7174390_2	509635.N824_00675	2.164e-66	243.0	COG4948@1|root,COG4948@2|Bacteria,4NIIJ@976|Bacteroidetes,1IUSW@117747|Sphingobacteriia	976|Bacteroidetes	M	Mandelate racemase muconate lactonizing enzyme, N-terminal domain	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_7174390_3	1382359.JIAL01000001_gene1751	1.333e-32	131.0	COG4319@1|root,COG4319@2|Bacteria,3Y5BE@57723|Acidobacteria,2JJS4@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_3
TLS2_k127_7180509_0	1267534.KB906754_gene2899	2.128e-49	181.0	COG0154@1|root,COG0154@2|Bacteria,3Y41H@57723|Acidobacteria,2JKKU@204432|Acidobacteriia	204432|Acidobacteriia	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS2_k127_7180509_1	745014.OMB55_00023870	3.823e-27	119.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_7182652_6	1097668.BYI23_E000110	2.601e-16	81.0	COG1917@1|root,COG1917@2|Bacteria,1RGZB@1224|Proteobacteria,2VSYK@28216|Betaproteobacteria,1K7T6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_7182652_5	1502851.FG93_01319	2.01e-16	79.0	COG1917@1|root,COG1917@2|Bacteria,1RGZB@1224|Proteobacteria,2U8ED@28211|Alphaproteobacteria,3JZ4I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_7182652_3	864069.MicloDRAFT_00014000	1.347e-48	177.0	COG1917@1|root,COG1917@2|Bacteria,1RH8X@1224|Proteobacteria,2U7MT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_7182652_0	404589.Anae109_1050	2.718e-175	554.0	COG0604@1|root,COG0604@2|Bacteria,1PFUG@1224|Proteobacteria,43DPN@68525|delta/epsilon subdivisions,2X9UD@28221|Deltaproteobacteria,2Z058@29|Myxococcales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
TLS2_k127_7182652_2	1449350.OCH239_11100	3.097e-83	277.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U5Q0@28211|Alphaproteobacteria,4KMHN@93682|Roseivivax	28211|Alphaproteobacteria	O	This stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
TLS2_k127_7182652_1	491916.RHECIAT_PC0000206	1.03e-92	308.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,4B9SN@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS2_k127_7182652_4	1459636.NTE_03091	1.559e-24	104.0	COG0431@1|root,arCOG04624@2157|Archaea,41T7Y@651137|Thaumarchaeota	651137|Thaumarchaeota	S	NADPH-dependent FMN reductase	-	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
TLS2_k127_718610_3	644283.Micau_4753	3.97e-06	49.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,4DCDB@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
TLS2_k127_718610_2	572477.Alvin_2459	2.629e-09	63.0	COG2010@1|root,COG2010@2|Bacteria,1N97E@1224|Proteobacteria,1SCE9@1236|Gammaproteobacteria,1WZFR@135613|Chromatiales	135613|Chromatiales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C
TLS2_k127_718610_0	42256.RradSPS_0959	1.711e-153	497.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4CPHW@84995|Rubrobacteria	201174|Actinobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TLS2_k127_718610_1	330214.NIDE3350	1.516e-47	175.0	COG2010@1|root,COG2010@2|Bacteria,3J17C@40117|Nitrospirae	2|Bacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	CopD,Cytochrome_CBB3
TLS2_k127_7199024_1	234267.Acid_0024	7.252e-154	518.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_7199024_3	234267.Acid_7492	4.598e-83	299.0	28P7U@1|root,2ZC21@2|Bacteria,3Y7PG@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7199024_8	1173023.KE650771_gene4106	1.318e-05	55.0	2AKF7@1|root,31B6Q@2|Bacteria,1G5KA@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7199024_2	278963.ATWD01000001_gene2573	1.858e-133	432.0	COG1262@1|root,COG1262@2|Bacteria,3Y4J6@57723|Acidobacteria,2JM73@204432|Acidobacteriia	204432|Acidobacteriia	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TLS2_k127_7199024_4	1267535.KB906767_gene720	1.136e-73	258.0	COG0760@1|root,COG0760@2|Bacteria,3Y8EB@57723|Acidobacteria,2JNN9@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM PPIC-type	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
TLS2_k127_7199024_6	66874.JOFS01000022_gene5716	1.604e-24	108.0	COG0784@1|root,COG0784@2|Bacteria,2IFH8@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	rcp1	-	-	ko:K02485	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg
TLS2_k127_7199024_7	1150600.ADIARSV_2228	2.951e-07	60.0	2A7Q4@1|root,30WNS@2|Bacteria,4PA1Z@976|Bacteroidetes,1ITZ9@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7199024_0	240015.ACP_2303	5.946e-219	690.0	COG1233@1|root,COG1233@2|Bacteria,3Y3I8@57723|Acidobacteria,2JI78@204432|Acidobacteriia	204432|Acidobacteriia	C	TIGRFAM phytoene desaturase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
TLS2_k127_7199024_5	1238182.C882_1170	7.553e-67	238.0	COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,2TR9T@28211|Alphaproteobacteria,2JVAH@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_7206154_0	926550.CLDAP_26240	5.452e-146	468.0	COG3962@1|root,COG3962@2|Bacteria,2G68S@200795|Chloroflexi	200795|Chloroflexi	E	Thiamine pyrophosphate enzyme, central domain	-	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_7206154_1	234267.Acid_1480	5.467e-124	402.0	COG3718@1|root,COG3718@2|Bacteria	2|Bacteria	G	enzyme involved in inositol metabolism	iolB	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
TLS2_k127_7206154_2	234267.Acid_1479	2.842e-101	338.0	COG1609@1|root,COG1609@2|Bacteria,3Y6K5@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K05499	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_7207943_0	1267535.KB906767_gene478	1.232e-181	589.0	COG1629@1|root,COG4771@2|Bacteria,3Y6Q2@57723|Acidobacteria,2JM5C@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_7207943_2	272624.lpg1089	2.512e-66	232.0	COG0500@1|root,COG2226@2|Bacteria,1RAAZ@1224|Proteobacteria,1S4TB@1236|Gammaproteobacteria,1JCDG@118969|Legionellales	118969|Legionellales	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_7207943_3	587753.EY04_12600	1.836e-34	134.0	2C82G@1|root,32RK9@2|Bacteria,1MZV5@1224|Proteobacteria,1SAWR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
TLS2_k127_7207943_1	195250.CM001776_gene4005	2.329e-134	443.0	COG0457@1|root,COG0457@2|Bacteria,1G31A@1117|Cyanobacteria	1117|Cyanobacteria	S	tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8
TLS2_k127_7215529_6	861299.J421_2225	3.266e-11	66.0	COG3119@1|root,COG3119@2|Bacteria,1ZUN9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_7215529_3	1122194.AUHU01000007_gene92	3.654e-88	300.0	COG3507@1|root,COG3507@2|Bacteria,1R10E@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
TLS2_k127_7215529_2	1340493.JNIF01000004_gene675	2.467e-109	359.0	COG0005@1|root,COG0005@2|Bacteria,3Y2MB@57723|Acidobacteria	57723|Acidobacteria	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	-	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_7215529_4	1336245.JAGO01000017_gene1152	2.943e-35	143.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,1RMRX@1236|Gammaproteobacteria,1XQ4F@135619|Oceanospirillales	135619|Oceanospirillales	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
TLS2_k127_7215529_0	234267.Acid_5235	2.291e-178	571.0	COG0402@1|root,COG0402@2|Bacteria,3Y64N@57723|Acidobacteria	57723|Acidobacteria	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS2_k127_7215529_5	1267535.KB906767_gene4332	1.807e-29	124.0	COG0494@1|root,COG0494@2|Bacteria,3Y4IG@57723|Acidobacteria	57723|Acidobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_7215529_1	1340493.JNIF01000003_gene2930	6.745e-110	368.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
TLS2_k127_7216204_4	1267535.KB906767_gene2162	1.198e-82	277.0	COG1069@1|root,COG1069@2|Bacteria,3Y3B6@57723|Acidobacteria,2JI84@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM Carbohydrate kinase	-	-	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100	-	R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
TLS2_k127_7216204_3	1267535.KB906767_gene2161	2.924e-92	313.0	COG0235@1|root,COG0235@2|Bacteria,3Y3W2@57723|Acidobacteria,2JHR0@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM Class II aldolase	-	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
TLS2_k127_7216204_1	880073.Calab_0031	6.807e-139	454.0	COG2017@1|root,COG2017@2|Bacteria,2NQA5@2323|unclassified Bacteria	2|Bacteria	G	Converts alpha-aldose to the beta-anomer	mro	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
TLS2_k127_7216204_5	745718.JADT01000021_gene2658	2.663e-64	226.0	COG2133@1|root,COG3291@1|root,COG5492@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG5492@2|Bacteria,4NEAB@976|Bacteroidetes,1HZEP@117743|Flavobacteriia	976|Bacteroidetes	N	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,Collagen_bind_2,DUF5060
TLS2_k127_7216204_0	234267.Acid_2816	6.644e-144	476.0	COG2273@1|root,COG3693@1|root,COG2273@2|Bacteria,COG3693@2|Bacteria,3Y4BI@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glycoside hydrolase, family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
TLS2_k127_7216204_2	616991.JPOO01000003_gene29	2.35e-112	374.0	2DDE1@1|root,2ZHNZ@2|Bacteria,4NNSM@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
TLS2_k127_7216204_6	357808.RoseRS_2678	4.511e-39	152.0	COG0622@1|root,COG0622@2|Bacteria,2G7DJ@200795|Chloroflexi	200795|Chloroflexi	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
TLS2_k127_7216204_7	234267.Acid_5285	3.481e-18	92.0	COG1216@1|root,COG1216@2|Bacteria,3Y5FE@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
TLS2_k127_7226861_0	1379270.AUXF01000003_gene3454	8.198e-99	336.0	COG1629@1|root,COG4771@2|Bacteria,1ZT9M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
TLS2_k127_7226861_1	861299.J421_6084	3.239e-70	257.0	28P8D@1|root,33QB6@2|Bacteria,1ZSQK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	SusD family	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD_RagB
TLS2_k127_7226861_2	1394178.AWOO02000031_gene4788	9.429e-07	53.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS2_k127_7230019_0	1123242.JH636436_gene3	1.945e-108	365.0	COG5433@1|root,COG5433@2|Bacteria,2IWUI@203682|Planctomycetes	203682|Planctomycetes	L	COG5433 Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
TLS2_k127_7233996_0	1340493.JNIF01000003_gene3565	5.158e-157	522.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_7258681_2	1267535.KB906767_gene3665	1.974e-17	86.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	5.3.99.11	ko:K06606	ko00562,ko01120,map00562,map01120	-	R09952	RC01513	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2,AP_endonuc_2_N,VCBS
TLS2_k127_7258681_1	1121472.AQWN01000008_gene2037	1.043e-100	336.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2607I@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS2_k127_7258681_0	1121904.ARBP01000011_gene1569	1.5e-137	443.0	COG3958@1|root,COG3958@2|Bacteria,4NEI8@976|Bacteroidetes,47JQN@768503|Cytophagia	976|Bacteroidetes	G	PFAM Transketolase, C-terminal domain	tktC	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_7258681_3	639030.JHVA01000001_gene1798	4.346e-05	52.0	COG3942@1|root,COG3942@2|Bacteria	2|Bacteria	S	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_3_5,CHAP,CW_binding_1,Flg_new,GBS_Bsp-like,Glucosaminidase,Glyco_hydro_25,RicinB_lectin_2
TLS2_k127_7260853_5	234267.Acid_2441	3.436e-21	102.0	COG2020@1|root,COG2020@2|Bacteria,3Y8EC@57723|Acidobacteria	57723|Acidobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TLS2_k127_7260853_0	234267.Acid_2416	2.476e-170	546.0	COG4287@1|root,COG4287@2|Bacteria	2|Bacteria	S	PhoPQ-activated pathogenicity-related protein	pqaA	-	-	-	-	-	-	-	-	-	-	-	PhoPQ_related
TLS2_k127_7260853_3	234267.Acid_7365	2.84e-28	124.0	2EQJB@1|root,33I5C@2|Bacteria,3Y5WN@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7260853_1	1340493.JNIF01000003_gene2363	1.771e-154	498.0	COG2855@1|root,COG2855@2|Bacteria,3Y5BA@57723|Acidobacteria	57723|Acidobacteria	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
TLS2_k127_7260853_2	1415754.JQMK01000002_gene3377	1.285e-56	203.0	COG0745@1|root,COG2909@1|root,COG0745@2|Bacteria,COG2909@2|Bacteria,1N5KV@1224|Proteobacteria,1SMMI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KT	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Trans_reg_C
TLS2_k127_7260853_6	1380394.JADL01000008_gene3605	1.2e-08	60.0	28JZQ@1|root,2Z9PN@2|Bacteria,1N2WN@1224|Proteobacteria,2U0QD@28211|Alphaproteobacteria,2JVCX@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7260853_7	1340493.JNIF01000003_gene4344	7.901e-05	46.0	28JZQ@1|root,2Z9PN@2|Bacteria,3Y4UW@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7272482_1	1267535.KB906767_gene4426	1.059e-89	310.0	COG4974@1|root,COG4974@2|Bacteria,3Y2VX@57723|Acidobacteria,2JHNZ@204432|Acidobacteriia	204432|Acidobacteriia	L	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_7272482_0	1267535.KB906767_gene4427	3.262e-181	574.0	COG1206@1|root,COG1206@2|Bacteria,3Y2KD@57723|Acidobacteria,2JIGU@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
TLS2_k127_7273345_5	234267.Acid_0193	1.172e-51	187.0	COG4409@1|root,COG4409@2|Bacteria,3Y7HZ@57723|Acidobacteria	57723|Acidobacteria	G	BNR repeat-like domain	-	-	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2
TLS2_k127_7273345_3	234267.Acid_6254	2.999e-62	215.0	COG4898@1|root,COG4898@2|Bacteria,3Y842@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterized protein conserved in bacteria (DUF2200)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2200
TLS2_k127_7273345_7	234267.Acid_1509	3.179e-06	53.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7273345_6	234267.Acid_1509	3.384e-34	145.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7273345_2	1267534.KB906754_gene3701	3.56e-92	318.0	COG0671@1|root,COG0671@2|Bacteria,3Y8DY@57723|Acidobacteria	2|Bacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,PAP2
TLS2_k127_7273345_0	62928.azo3706	4.697e-181	571.0	COG0500@1|root,COG0500@2|Bacteria,1N3PV@1224|Proteobacteria,2VK53@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_7273345_1	1323663.AROI01000002_gene1024	5.891e-162	517.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1RP9W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
TLS2_k127_7273345_4	1340493.JNIF01000003_gene3150	1.229e-52	195.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_7277303_0	234267.Acid_6935	0.0	1324.0	COG3459@1|root,COG3459@2|Bacteria,3Y3E9@57723|Acidobacteria	57723|Acidobacteria	G	Putative glucoamylase	-	-	-	-	-	-	-	-	-	-	-	-	Glycoamylase
TLS2_k127_7277303_1	1123277.KB893180_gene2411	1.063e-244	766.0	COG3664@1|root,COG3664@2|Bacteria,4NHQ0@976|Bacteroidetes,47N7Z@768503|Cytophagia	976|Bacteroidetes	G	PFAM glycoside hydrolase family 39	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_39
TLS2_k127_7291933_6	1279009.ADICEAN_02886	3.472e-110	365.0	COG4221@1|root,COG4221@2|Bacteria,4NFX8@976|Bacteroidetes,47NCT@768503|Cytophagia	976|Bacteroidetes	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_7291933_2	344747.PM8797T_10564	2.783e-178	563.0	COG1063@1|root,COG1063@2|Bacteria,2IX2U@203682|Planctomycetes	203682|Planctomycetes	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_7291933_8	861299.J421_6319	2.757e-31	136.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Condensation,Glycos_transf_1,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31,PP-binding,TPR_1,TPR_16,TPR_8
TLS2_k127_7291933_5	251221.35211045	1.149e-120	391.0	COG2746@1|root,COG2746@2|Bacteria,1G8Z6@1117|Cyanobacteria	1117|Cyanobacteria	V	Aminoglycoside 3-N-acetyltransferase	-	-	2.3.1.81	ko:K00662	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Antibiotic_NAT
TLS2_k127_7291933_4	1340493.JNIF01000003_gene1883	9.822e-137	445.0	COG1304@1|root,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	-	-	1.1.3.15,1.1.3.46	ko:K00104,ko:K16422	ko00261,ko00630,ko01055,ko01100,ko01110,ko01120,ko01130,map00261,map00630,map01055,map01100,map01110,map01120,map01130	-	R00475,R06633	RC00042,RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
TLS2_k127_7291933_0	292415.Tbd_1072	0.0	1010.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VS7B@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2
TLS2_k127_7291933_3	1267535.KB906767_gene628	2.087e-175	561.0	COG5000@1|root,COG5000@2|Bacteria,3Y2TD@57723|Acidobacteria,2JHXU@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
TLS2_k127_7291933_1	1267535.KB906767_gene629	1.698e-218	685.0	COG2204@1|root,COG2204@2|Bacteria,3Y33M@57723|Acidobacteria,2JHW9@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_7291933_7	518766.Rmar_2853	2.511e-58	222.0	COG0210@1|root,COG0841@1|root,COG0210@2|Bacteria,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7297961_2	1267535.KB906767_gene3137	6.912e-175	572.0	COG4206@1|root,COG4206@2|Bacteria	2|Bacteria	H	cobalamin-transporting ATPase activity	btuB	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
TLS2_k127_7297961_27	234267.Acid_1547	2.122e-28	121.0	COG0745@1|root,COG0745@2|Bacteria	234267.Acid_1547|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7297961_13	313612.L8106_11247	3.269e-84	298.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,1HH3F@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9
TLS2_k127_7297961_19	1215114.BBIU01000009_gene1514	3.817e-62	218.0	COG0745@1|root,COG0745@2|Bacteria,1RD6H@1224|Proteobacteria,1S623@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_7297961_1	648885.KB316282_gene311	1.041e-255	809.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2TWHG@28211|Alphaproteobacteria,1JSRP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Phytochrome central region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF,HATPase_c,HisKA,PAS_2,PHY,Response_reg
TLS2_k127_7297961_25	1504672.669785508	1.617e-31	131.0	COG3230@1|root,COG3230@2|Bacteria,1N9VG@1224|Proteobacteria,2VVRM@28216|Betaproteobacteria,4AFXK@80864|Comamonadaceae	28216|Betaproteobacteria	P	Heme oxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Heme_oxygenase
TLS2_k127_7297961_3	886293.Sinac_0925	1.374e-143	471.0	COG3119@1|root,COG3119@2|Bacteria,2IXPB@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
TLS2_k127_7297961_28	661478.OP10G_4489	1.441e-22	106.0	2A52F@1|root,30TQU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7297961_26	204669.Acid345_4313	2.16e-30	123.0	COG3795@1|root,COG3795@2|Bacteria,3Y5P2@57723|Acidobacteria,2JNPR@204432|Acidobacteriia	204432|Acidobacteriia	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_7297961_5	204669.Acid345_4314	9.866e-132	439.0	COG4941@1|root,COG4941@2|Bacteria,3Y42G@57723|Acidobacteria,2JM1K@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
TLS2_k127_7297961_14	518766.Rmar_2790	1.528e-83	297.0	COG2303@1|root,COG2303@2|Bacteria,4NEHP@976|Bacteroidetes,1FKEH@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N
TLS2_k127_7297961_29	1192034.CAP_8773	8.021e-20	96.0	COG2262@1|root,COG3173@1|root,COG2262@2|Bacteria,COG3173@2|Bacteria,1MUA0@1224|Proteobacteria,42MK8@68525|delta/epsilon subdivisions,2WMI7@28221|Deltaproteobacteria,2YY33@29|Myxococcales	28221|Deltaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	-	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TLS2_k127_7297961_21	1444309.JAQG01000157_gene3226	3.316e-45	169.0	COG3173@1|root,COG3173@2|Bacteria,1TPYB@1239|Firmicutes,4HBYQ@91061|Bacilli,26SXV@186822|Paenibacillaceae	91061|Bacilli	S	Phosphotransferase enzyme family	ycbJ	-	-	ko:K06979	-	M00760	-	-	br01600,ko00000,ko00002,ko01504	-	-	-	APH
TLS2_k127_7297961_11	1255043.TVNIR_3529	5.719e-88	299.0	2FFXP@1|root,347UK@2|Bacteria,1P1PS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7297961_4	234267.Acid_2370	8.6e-137	445.0	COG0687@1|root,COG0687@2|Bacteria,3Y5JD@57723|Acidobacteria	57723|Acidobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
TLS2_k127_7297961_9	1340493.JNIF01000003_gene2567	6.251e-95	317.0	COG1177@1|root,COG1177@2|Bacteria,3Y57S@57723|Acidobacteria	57723|Acidobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS2_k127_7297961_7	234267.Acid_2368	8.241e-107	353.0	COG1176@1|root,COG1176@2|Bacteria,3Y531@57723|Acidobacteria	57723|Acidobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS2_k127_7297961_12	1229172.JQFA01000002_gene3752	2.57e-86	295.0	COG3842@1|root,COG3842@2|Bacteria,1G1HQ@1117|Cyanobacteria,1H7K4@1150|Oscillatoriales	1117|Cyanobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
TLS2_k127_7297961_20	1519464.HY22_01470	2.342e-51	195.0	COG0590@1|root,COG0590@2|Bacteria,1FF9Z@1090|Chlorobi	1090|Chlorobi	FJ	MafB19-like deaminase	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
TLS2_k127_7297961_17	1267535.KB906767_gene750	7.751e-69	241.0	COG0503@1|root,COG0503@2|Bacteria,3Y30R@57723|Acidobacteria,2JHP2@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
TLS2_k127_7297961_16	1267535.KB906767_gene749	1.052e-77	274.0	COG1947@1|root,COG1947@2|Bacteria,3Y55D@57723|Acidobacteria,2JP3B@204432|Acidobacteriia	204432|Acidobacteriia	I	GHMP kinases C terminal	-	-	-	-	-	-	-	-	-	-	-	-	GHMP_kinases_C
TLS2_k127_7297961_15	234267.Acid_1442	4.872e-83	293.0	COG0642@1|root,COG2205@2|Bacteria	234267.Acid_1442|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7297961_23	234267.Acid_6222	1.269e-40	157.0	COG0781@1|root,COG0781@2|Bacteria,3Y4Z7@57723|Acidobacteria	57723|Acidobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
TLS2_k127_7297961_18	234267.Acid_6223	6.723e-68	237.0	COG0054@1|root,COG0054@2|Bacteria,3Y3RR@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
TLS2_k127_7297961_8	234267.Acid_6224	3.168e-96	321.0	COG1024@1|root,COG1024@2|Bacteria,3Y47B@57723|Acidobacteria	57723|Acidobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS2_k127_7297961_0	1267535.KB906767_gene3806	0.0	1039.0	COG0481@1|root,COG0481@2|Bacteria,3Y3EX@57723|Acidobacteria,2JI4G@204432|Acidobacteriia	204432|Acidobacteriia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
TLS2_k127_7297961_22	204669.Acid345_0118	4.983e-44	166.0	2CK1C@1|root,32SJA@2|Bacteria,3Y543@57723|Acidobacteria,2JJTF@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7297961_10	717605.Theco_0542	6.808e-93	324.0	COG1312@1|root,COG1312@2|Bacteria,1TP5F@1239|Firmicutes,4H9UR@91061|Bacilli,26TTG@186822|Paenibacillaceae	91061|Bacilli	G	D-mannonate dehydratase (UxuA)	-	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
TLS2_k127_7297961_24	204669.Acid345_1671	1.531e-37	147.0	COG2318@1|root,COG2318@2|Bacteria,3Y4U3@57723|Acidobacteria,2JJEH@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_7297961_6	1121904.ARBP01000029_gene2184	1.069e-119	404.0	COG4654@1|root,COG4654@2|Bacteria	2|Bacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PSCyt1,PSCyt2,PSD1
TLS2_k127_7311139_1	234267.Acid_5700	8.226e-191	610.0	COG1022@1|root,COG1022@2|Bacteria	2|Bacteria	I	Amp-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,Acetyltransf_1
TLS2_k127_7311139_0	234267.Acid_5726	5.861e-273	848.0	COG2303@1|root,COG2303@2|Bacteria,3Y781@57723|Acidobacteria	57723|Acidobacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C
TLS2_k127_7311139_2	234267.Acid_5703	1.177e-135	449.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_5703|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7311839_5	234267.Acid_2402	4.103e-17	81.0	COG5002@1|root,COG5002@2|Bacteria,3Y99C@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_7311839_4	234267.Acid_2403	9.183e-93	313.0	COG0745@1|root,COG0745@2|Bacteria,3Y4FA@57723|Acidobacteria	57723|Acidobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_7311839_1	314230.DSM3645_14945	1.883e-162	519.0	COG0673@1|root,COG0673@2|Bacteria,2IXUF@203682|Planctomycetes	2|Bacteria	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_7311839_3	344747.PM8797T_21863	8.628e-103	347.0	COG3540@1|root,COG3540@2|Bacteria,2J2PG@203682|Planctomycetes	203682|Planctomycetes	P	alkaline phosphatase D	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	PhoD,PhoD_N
TLS2_k127_7311839_6	595460.RRSWK_03617	4.166e-07	57.0	COG3540@1|root,COG3540@2|Bacteria,2J1QH@203682|Planctomycetes	203682|Planctomycetes	P	PhoD-like phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PhoD
TLS2_k127_7311839_0	639030.JHVA01000001_gene1886	1.753e-268	863.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_7311839_7	1040986.ATYO01000001_gene2032	1.324e-05	50.0	COG2940@1|root,COG2940@2|Bacteria,1NG0H@1224|Proteobacteria,2UGDU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
TLS2_k127_7311839_2	1267535.KB906767_gene4106	1.277e-146	477.0	COG3118@1|root,COG3118@2|Bacteria,3Y99P@57723|Acidobacteria	57723|Acidobacteria	O	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS2_k127_7313426_1	189753.AXAS01000037_gene7858	4.37e-142	459.0	COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,2UEEB@28211|Alphaproteobacteria,3K063@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
TLS2_k127_7313426_0	234267.Acid_1198	7.064e-217	686.0	COG1321@1|root,COG1321@2|Bacteria	2|Bacteria	K	iron dependent repressor	nagC	-	-	ko:K02003,ko:K02565,ko:K15545	-	M00258	-	-	ko00000,ko00002,ko02000,ko03000	3.A.1	-	-	HTH_IclR,MarR,ROK
TLS2_k127_7313426_2	1340493.JNIF01000003_gene2532	1.096e-31	127.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_7316134_3	1340493.JNIF01000003_gene3205	3.193e-23	98.0	COG0050@1|root,COG0050@2|Bacteria,3Y2JG@57723|Acidobacteria	57723|Acidobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TLS2_k127_7316134_4	234267.Acid_6323	2.262e-20	90.0	COG0267@1|root,COG0267@2|Bacteria,3Y5UB@57723|Acidobacteria	57723|Acidobacteria	J	structural constituent of ribosome	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
TLS2_k127_7316134_5	1340493.JNIF01000003_gene3826	8.76e-17	83.0	COG0690@1|root,COG0690@2|Bacteria,3Y5R4@57723|Acidobacteria	57723|Acidobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
TLS2_k127_7316134_1	1267535.KB906767_gene4464	1.143e-91	307.0	COG0250@1|root,COG0250@2|Bacteria,3Y3ZR@57723|Acidobacteria,2JHU8@204432|Acidobacteriia	204432|Acidobacteriia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
TLS2_k127_7316134_2	1267535.KB906767_gene4465	1.496e-75	254.0	COG0080@1|root,COG0080@2|Bacteria,3Y7H1@57723|Acidobacteria	57723|Acidobacteria	J	Ribosomal protein L11/L12	-	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
TLS2_k127_7316134_7	1502851.FG93_04275	3.75e-08	64.0	COG0500@1|root,COG2226@2|Bacteria,1PE78@1224|Proteobacteria,2V82K@28211|Alphaproteobacteria,3K5JW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_7316134_0	234267.Acid_6473	1.305e-201	643.0	COG1109@1|root,COG1109@2|Bacteria	2|Bacteria	G	phosphoglucosamine mutase activity	algC	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_7316134_6	1340493.JNIF01000004_gene1009	1.495e-16	81.0	COG0391@1|root,COG0391@2|Bacteria,3Y3ZE@57723|Acidobacteria	57723|Acidobacteria	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
TLS2_k127_7325087_1	338966.Ppro_3583	3.801e-65	231.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WPKC@28221|Deltaproteobacteria,43UBP@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
TLS2_k127_7325087_0	204669.Acid345_2092	9.35e-201	639.0	COG0595@1|root,COG0595@2|Bacteria,3Y2NH@57723|Acidobacteria,2JI53@204432|Acidobacteriia	204432|Acidobacteriia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
TLS2_k127_7337614_6	234267.Acid_7429	6.359e-30	121.0	2F82T@1|root,340G8@2|Bacteria,3Y8B9@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7337614_7	215803.DB30_8035	1.387e-11	75.0	COG4932@1|root,COG4932@2|Bacteria,1NXIX@1224|Proteobacteria,430KM@68525|delta/epsilon subdivisions,2WVSB@28221|Deltaproteobacteria,2YYGY@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_7337614_4	156889.Mmc1_0444	7.045e-39	159.0	COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria	1224|Proteobacteria	O	DSBA oxidoreductase	MA20_20720	-	-	-	-	-	-	-	-	-	-	-	DSBA,Thioredoxin_4
TLS2_k127_7337614_3	1121377.KB906418_gene3787	4.26e-51	193.0	COG5640@1|root,COG5640@2|Bacteria,1WN2M@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Trypsin-like serine protease	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin
TLS2_k127_7337614_0	234267.Acid_3331	3.974e-163	524.0	COG0673@1|root,COG0673@2|Bacteria,3Y2KV@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_7337614_1	497964.CfE428DRAFT_3855	1.484e-153	492.0	COG0620@1|root,COG0620@2|Bacteria,46W8R@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Cobalamin-independent synthase, Catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
TLS2_k127_7337614_2	234267.Acid_3333	3.747e-148	482.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	4.2.2.6	ko:K01730	ko00040,map00040	-	R04382	RC02124,RC02427	ko00000,ko00001,ko01000	-	-	-	OmpA,PD40,PI-PLC-X,Pectate_lyase22,TIR_2
TLS2_k127_7337614_5	234267.Acid_0988	9.575e-32	127.0	COG3571@1|root,COG3571@2|Bacteria,3Y7N8@57723|Acidobacteria	57723|Acidobacteria	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	Abhydrolase_5,Abhydrolase_6
TLS2_k127_7337640_2	204669.Acid345_4420	2.699e-21	100.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_7337640_0	1541065.JRFE01000019_gene3218	3.913e-22	108.0	2FFI5@1|root,347FM@2|Bacteria,1GFIA@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7337640_1	118173.KB235914_gene2257	2.104e-21	96.0	COG3668@1|root,COG3668@2|Bacteria,1G8P7@1117|Cyanobacteria,1HC8S@1150|Oscillatoriales	1117|Cyanobacteria	S	Addiction module toxin, RelE StbE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
TLS2_k127_7340704_0	1267535.KB906767_gene1184	2.424e-135	436.0	COG0247@1|root,COG0247@2|Bacteria,3Y3K8@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
TLS2_k127_7340704_1	1267535.KB906767_gene3218	4.369e-113	370.0	COG0468@1|root,COG0468@2|Bacteria,3Y3Y1@57723|Acidobacteria,2JHU1@204432|Acidobacteriia	57723|Acidobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	-	-	-	-	-	-	-	-	-	-	-	-	RecA
TLS2_k127_7347265_10	234267.Acid_1479	2.345e-17	85.0	COG1609@1|root,COG1609@2|Bacteria,3Y6K5@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K05499	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_7347265_4	639030.JHVA01000001_gene112	2.597e-152	490.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TLS2_k127_7347265_0	234267.Acid_1478	0.0	1253.0	COG1629@1|root,COG1629@2|Bacteria,3Y99Y@57723|Acidobacteria	57723|Acidobacteria	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_7347265_7	1267535.KB906767_gene38	1.165e-55	200.0	COG1695@1|root,COG1695@2|Bacteria,3Y4XK@57723|Acidobacteria,2JJR3@204432|Acidobacteriia	2|Bacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_7347265_1	1267535.KB906767_gene39	1.04e-311	976.0	COG0577@1|root,COG0577@2|Bacteria,3Y47F@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_7347265_3	497964.CfE428DRAFT_6403	1.376e-248	772.0	COG2960@1|root,COG2960@2|Bacteria,46UNH@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
TLS2_k127_7347265_2	240016.ABIZ01000001_gene180	6.286e-269	844.0	COG0551@1|root,COG2010@1|root,COG0551@2|Bacteria,COG2010@2|Bacteria,46TGC@74201|Verrucomicrobia	74201|Verrucomicrobia	CL	Protein of unknown function (DUF1587)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5
TLS2_k127_7347265_8	1267534.KB906755_gene4735	4.908e-46	170.0	COG2764@1|root,COG2764@2|Bacteria	2|Bacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_7347265_11	3067.XP_002946260.1	0.000255	47.0	KOG0274@1|root,KOG0274@2759|Eukaryota,37ZGC@33090|Viridiplantae,34JVT@3041|Chlorophyta	3041|Chlorophyta	S	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	WD40
TLS2_k127_7347265_6	234267.Acid_6616	9.792e-59	214.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7347265_5	682795.AciX8_0910	1.371e-64	234.0	COG1493@1|root,COG1493@2|Bacteria,3Y4YI@57723|Acidobacteria,2JK5E@204432|Acidobacteriia	204432|Acidobacteriia	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7347265_9	234267.Acid_6621	2.524e-26	115.0	COG1596@1|root,COG1596@2|Bacteria	2|Bacteria	M	polysaccharide export	-	-	-	ko:K01991,ko:K16552	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18,1.B.18.1	-	-	NTP_transf_5,Poly_export,SLBB
TLS2_k127_7349312_3	234267.Acid_6621	1.655e-38	164.0	COG1596@1|root,COG1596@2|Bacteria	2|Bacteria	M	polysaccharide export	-	-	-	ko:K01991,ko:K16552	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18,1.B.18.1	-	-	NTP_transf_5,Poly_export,SLBB
TLS2_k127_7349312_4	304371.MCP_2648	3.167e-07	63.0	COG0477@1|root,arCOG00132@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_7349312_1	234267.Acid_6620	3.001e-77	272.0	COG0438@1|root,COG0438@2|Bacteria,3Y4F9@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_7349312_0	234267.Acid_6619	5.129e-133	439.0	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	ko:K02847,ko:K13009	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	PglL_A,Wzy_C,Wzy_C_2
TLS2_k127_7349312_2	234267.Acid_6618	6.857e-57	213.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	GNVR,Wzz
TLS2_k127_7350533_2	234267.Acid_3978	7.599e-66	229.0	COG2271@1|root,COG2271@2|Bacteria,3Y638@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_7350533_1	234267.Acid_1104	4.127e-94	319.0	COG1250@1|root,COG1250@2|Bacteria,3Y3S5@57723|Acidobacteria	57723|Acidobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_7350533_0	1340493.JNIF01000003_gene4275	3.284e-213	678.0	COG1629@1|root,COG4771@2|Bacteria,3Y6PD@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_7355890_0	1340493.JNIF01000003_gene2166	4.836e-284	897.0	COG1629@1|root,COG4771@2|Bacteria,3Y36T@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_7359602_2	1267535.KB906767_gene601	2.213e-114	380.0	COG1472@1|root,COG1472@2|Bacteria,3Y6UR@57723|Acidobacteria	57723|Acidobacteria	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
TLS2_k127_7359602_3	234267.Acid_3917	4.425e-108	353.0	COG2220@1|root,COG2220@2|Bacteria,3Y4RK@57723|Acidobacteria	57723|Acidobacteria	S	hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
TLS2_k127_7359602_6	1267535.KB906767_gene5446	6.187e-23	103.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	1.20.4.3	ko:K03676,ko:K18917	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Glutaredoxin
TLS2_k127_7359602_7	1382359.JIAL01000001_gene378	7.846e-10	66.0	2EQAC@1|root,33HWH@2|Bacteria,3Y5W6@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7359602_5	234267.Acid_0917	3.619e-30	119.0	COG1278@1|root,COG1278@2|Bacteria,3Y5NU@57723|Acidobacteria	57723|Acidobacteria	K	PFAM Cold-shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_7359602_1	1267535.KB906767_gene1457	0.0	1236.0	COG0188@1|root,COG0188@2|Bacteria,3Y2G5@57723|Acidobacteria,2JIR8@204432|Acidobacteriia	204432|Acidobacteriia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS2_k127_7359602_0	234267.Acid_4427	0.0	1270.0	COG1196@1|root,COG1196@2|Bacteria,3Y2W1@57723|Acidobacteria	57723|Acidobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
TLS2_k127_7359602_4	1163617.SCD_n02090	3.573e-90	309.0	COG3409@1|root,COG3409@2|Bacteria,1R7JY@1224|Proteobacteria,2VY5B@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7364734_2	5145.XP_001907707.1	2.422e-67	239.0	KOG0271@1|root,KOG0272@1|root,KOG0271@2759|Eukaryota,KOG0272@2759|Eukaryota,3AFR9@33154|Opisthokonta,3Q43U@4751|Fungi,3RM8R@4890|Ascomycota,21RIB@147550|Sordariomycetes,3UF1P@5139|Sordariales	4751|Fungi	A	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	HET,NACHT,WD40
TLS2_k127_7364734_3	1282361.ABAC402_17875	3.323e-54	201.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_4,Ank_5
TLS2_k127_7364734_1	1116369.KB890024_gene3237	1.358e-89	312.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2VF1X@28211|Alphaproteobacteria,43NU8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K18988	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Beta-lactamase,DUF3471
TLS2_k127_7364734_0	1340493.JNIF01000003_gene1695	3.945e-188	595.0	2CEN7@1|root,2Z9XA@2|Bacteria,3Y7AS@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7366055_1	234267.Acid_7109	4.778e-193	616.0	COG3669@1|root,COG3669@2|Bacteria,3Y6KY@57723|Acidobacteria	57723|Acidobacteria	G	Alpha-L-fucosidase C-terminal domain	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
TLS2_k127_7366055_2	1168034.FH5T_15595	7.999e-72	258.0	COG3356@1|root,COG3356@2|Bacteria,4NU9C@976|Bacteroidetes,2FRG0@200643|Bacteroidia	976|Bacteroidetes	S	PFAM Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
TLS2_k127_7366055_0	1237149.C900_05550	1.223e-256	812.0	COG1506@1|root,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,47KF8@768503|Cytophagia	976|Bacteroidetes	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
TLS2_k127_7366055_3	641524.ADICYQ_0168	6.394e-25	106.0	COG5476@1|root,COG5476@2|Bacteria,4NKYT@976|Bacteroidetes,47XQY@768503|Cytophagia	976|Bacteroidetes	S	MlrC C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
TLS2_k127_7367994_1	886293.Sinac_7009	1.37e-31	127.0	COG2010@1|root,COG2010@2|Bacteria,2IY6K@203682|Planctomycetes	203682|Planctomycetes	C	Protein of unknown function (DUF1549)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_7367994_0	1340493.JNIF01000003_gene3115	1.124e-242	758.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_7367994_2	194439.CT0820	0.0007619	44.0	COG5304@1|root,COG5304@2|Bacteria,1FFA4@1090|Chlorobi	1090|Chlorobi	S	CopG antitoxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	CopG_antitoxin
TLS2_k127_7371716_1	234267.Acid_7180	1.506e-200	640.0	COG1331@1|root,COG1331@2|Bacteria,3Y3AA@57723|Acidobacteria	57723|Acidobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
TLS2_k127_7371716_7	234267.Acid_7179	1.856e-67	235.0	COG2077@1|root,COG2077@2|Bacteria,3Y5DK@57723|Acidobacteria	57723|Acidobacteria	O	Redoxin	-	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
TLS2_k127_7371716_0	234267.Acid_3545	1.177e-226	712.0	COG3653@1|root,COG3653@2|Bacteria,3Y3Q2@57723|Acidobacteria	57723|Acidobacteria	Q	D-aminoacylase domain protein	-	-	3.5.1.81,3.5.2.3	ko:K01465,ko:K06015	ko00240,ko01100,map00240,map01100	M00051	R01993,R02192	RC00064,RC00328,RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
TLS2_k127_7371716_4	1267535.KB906767_gene1747	1.219e-129	420.0	COG0777@1|root,COG0777@2|Bacteria,3Y2U9@57723|Acidobacteria,2JI81@204432|Acidobacteriia	204432|Acidobacteriia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_7371716_5	234267.Acid_2381	1.009e-90	312.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.303	ko:K20421	ko01059,ko01130,map01059,map01130	M00830	R10963	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Dimerisation2,Methyltransf_2,Methyltransf_25
TLS2_k127_7371716_3	1123242.JH636435_gene1109	2.425e-153	491.0	COG3386@1|root,COG3386@2|Bacteria,2IXZT@203682|Planctomycetes	203682|Planctomycetes	G	gluconolactonase	-	-	-	-	-	-	-	-	-	-	-	-	SGL
TLS2_k127_7371716_6	1230476.C207_03775	4.023e-86	286.0	COG3832@1|root,COG3832@2|Bacteria,1MZXG@1224|Proteobacteria,2UBQP@28211|Alphaproteobacteria,3JQZP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_7371716_10	762376.AXYL_04223	3.581e-19	93.0	COG3832@1|root,COG3832@2|Bacteria,1RI3S@1224|Proteobacteria,2VVCX@28216|Betaproteobacteria,3T844@506|Alcaligenaceae	28216|Betaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_7371716_9	887062.HGR_07616	1.689e-27	116.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2VU68@28216|Betaproteobacteria,4AF78@80864|Comamonadaceae	28216|Betaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS2_k127_7371716_8	608538.HTH_0056	4.873e-33	132.0	COG2346@1|root,COG2346@2|Bacteria,2G5AF@200783|Aquificae	200783|Aquificae	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
TLS2_k127_7371716_2	502025.Hoch_6445	1.753e-158	507.0	COG3488@1|root,COG3488@2|Bacteria	2|Bacteria	C	Di-haem oxidoreductase, putative peroxidase	-	-	3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH30	-	DHOR
TLS2_k127_7371901_2	118173.KB235914_gene1175	3.143e-69	251.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,1HH3F@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
TLS2_k127_7371901_0	1267535.KB906767_gene5487	2.11e-103	344.0	COG0583@1|root,COG0583@2|Bacteria,3Y74M@57723|Acidobacteria	57723|Acidobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_7371901_7	1267535.KB906767_gene2145	0.0001227	51.0	2CK2Y@1|root,32SBF@2|Bacteria,3Y5PZ@57723|Acidobacteria,2JNJR@204432|Acidobacteriia	204432|Acidobacteriia	S	Photosynthetic reaction centre cytochrome C subunit	-	-	-	-	-	-	-	-	-	-	-	-	CytoC_RC
TLS2_k127_7371901_4	234267.Acid_2812	2.463e-36	141.0	COG0822@1|root,COG0822@2|Bacteria,3Y4B9@57723|Acidobacteria	57723|Acidobacteria	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS2_k127_7371901_3	1267535.KB906767_gene424	1.479e-47	177.0	COG0494@1|root,COG0494@2|Bacteria,3Y55X@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS2_k127_7371901_1	1430440.MGMSRv2_1357	1.32e-102	355.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2JUYE@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Response_reg
TLS2_k127_7371901_6	693986.MOC_2599	1.9e-24	105.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2TSGV@28211|Alphaproteobacteria,1JT90@119045|Methylobacteriaceae	28211|Alphaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
TLS2_k127_7382470_2	344747.PM8797T_14594	7.98e-141	462.0	COG3119@1|root,COG3119@2|Bacteria,2IYRK@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_7382470_1	234267.Acid_7200	6.044e-153	497.0	COG0820@1|root,COG0820@2|Bacteria,3Y3HQ@57723|Acidobacteria	57723|Acidobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
TLS2_k127_7382470_0	1267535.KB906767_gene3778	1.121e-198	640.0	COG2010@1|root,COG2010@2|Bacteria,3Y6T1@57723|Acidobacteria,2JM3M@204432|Acidobacteriia	204432|Acidobacteriia	C	Protein of unknown function (DUF1553)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_7383668_1	335541.Swol_1082	7.443e-103	344.0	COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,2481R@186801|Clostridia,42KI4@68298|Syntrophomonadaceae	186801|Clostridia	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
TLS2_k127_7383668_0	204669.Acid345_3483	4.807e-112	374.0	COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,3Y46R@57723|Acidobacteria,2JICT@204432|Acidobacteriia	204432|Acidobacteriia	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
TLS2_k127_738382_1	1146883.BLASA_1735	3.301e-54	204.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS2_k127_738382_0	1123248.KB893381_gene971	3.32e-102	347.0	COG0673@1|root,COG0673@2|Bacteria,4P1NH@976|Bacteroidetes	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_738382_2	1340493.JNIF01000003_gene2233	9.638e-41	154.0	COG2080@1|root,COG2080@2|Bacteria,3Y5EJ@57723|Acidobacteria	57723|Acidobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_7390459_5	1267535.KB906767_gene3789	4.781e-05	50.0	COG0558@1|root,COG0558@2|Bacteria,3Y427@57723|Acidobacteria,2JID7@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_7390459_4	1121904.ARBP01000003_gene6151	6.671e-66	253.0	28KJN@1|root,2ZA4P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7390459_2	111780.Sta7437_0576	1.808e-86	316.0	COG3507@1|root,COG3507@2|Bacteria,1GQES@1117|Cyanobacteria	1117|Cyanobacteria	G	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1349
TLS2_k127_7390459_0	1123322.KB904656_gene685	4.098e-98	342.0	2DBT1@1|root,2ZAV2@2|Bacteria,2H4J7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7390459_1	1267535.KB906767_gene1185	2.03e-91	310.0	COG1082@1|root,COG1082@2|Bacteria,3Y7BC@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_7390459_3	1267535.KB906767_gene5280	5.845e-67	233.0	COG1329@1|root,COG1329@2|Bacteria,3Y4ZG@57723|Acidobacteria,2JMXA@204432|Acidobacteriia	204432|Acidobacteriia	K	CarD-like/TRCF domain	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
TLS2_k127_7390489_1	234267.Acid_1285	2.436e-87	293.0	COG0317@1|root,COG0317@2|Bacteria,3Y38Q@57723|Acidobacteria	57723|Acidobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TLS2_k127_7390489_5	1340493.JNIF01000003_gene1842	1.205e-40	153.0	COG3536@1|root,COG3536@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF971)	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	DUF971
TLS2_k127_7390489_4	1267535.KB906767_gene4776	3.697e-79	272.0	COG2197@1|root,COG2197@2|Bacteria,3Y6T2@57723|Acidobacteria,2JMQ5@204432|Acidobacteriia	204432|Acidobacteriia	T	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_7390489_2	1267535.KB906767_gene2296	3.218e-84	296.0	COG4585@1|root,COG4585@2|Bacteria,3Y59R@57723|Acidobacteria	2|Bacteria	T	PFAM ATP-binding region, ATPase domain protein domain protein	-	-	2.7.13.3	ko:K07683	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF_2,HATPase_c,HisKA_3,PAS,PAS_9,Pkinase
TLS2_k127_7390489_0	234267.Acid_7569	8.881e-100	340.0	COG0845@1|root,COG0845@2|Bacteria,3Y2XB@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TLS2_k127_7390489_3	497964.CfE428DRAFT_0384	6.126e-83	278.0	COG0841@1|root,COG0841@2|Bacteria,46S7J@74201|Verrucomicrobia	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TLS2_k127_7395457_3	234267.Acid_0488	9.263e-62	218.0	COG1446@1|root,COG1446@2|Bacteria,3Y2Y8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM peptidase T2 asparaginase 2	-	-	3.5.1.26	ko:K01444	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Asparaginase_2
TLS2_k127_7395457_1	1267535.KB906767_gene5472	4.648e-200	628.0	COG1960@1|root,COG1960@2|Bacteria,3Y3T6@57723|Acidobacteria,2JIV6@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_7395457_2	234267.Acid_6234	3.738e-116	388.0	COG1682@1|root,COG1682@2|Bacteria,3Y8HI@57723|Acidobacteria	57723|Acidobacteria	GM	ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
TLS2_k127_7395457_0	234267.Acid_6233	6.303e-291	905.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.294,2.7.1.181	ko:K18827	-	-	R10657,R10658	RC00002,RC00003,RC00078,RC03220	ko00000,ko01000,ko01005	-	-	-	Glyco_trans_1_4,Glycos_transf_1,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25
TLS2_k127_7395457_5	1340493.JNIF01000003_gene2968	5.059e-40	151.0	COG0438@1|root,COG0438@2|Bacteria,3Y58K@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_7396563_4	1340493.JNIF01000003_gene1464	1.188e-51	186.0	COG1024@1|root,COG1024@2|Bacteria,3Y3SE@57723|Acidobacteria	57723|Acidobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_7396563_6	1267535.KB906767_gene3952	4.485e-42	158.0	2CIU6@1|root,32S8H@2|Bacteria,3Y8IT@57723|Acidobacteria,2JNTU@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7396563_1	1267535.KB906767_gene3953	2.316e-217	681.0	COG3185@1|root,COG3185@2|Bacteria,3Y2XN@57723|Acidobacteria,2JMM4@204432|Acidobacteriia	204432|Acidobacteriia	E	Acyclic terpene utilisation family protein AtuA	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
TLS2_k127_7396563_2	1267535.KB906767_gene4493	1.89e-122	406.0	COG0477@1|root,COG2814@2|Bacteria,3Y4T2@57723|Acidobacteria,2JKF4@204432|Acidobacteriia	204432|Acidobacteriia	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_7396563_5	234267.Acid_0397	8.132e-48	175.0	COG1832@1|root,COG1832@2|Bacteria	2|Bacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
TLS2_k127_7396563_3	234267.Acid_7567	1.093e-97	334.0	COG1538@1|root,COG1538@2|Bacteria,3Y3JU@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
TLS2_k127_7396563_0	1267535.KB906767_gene4770	0.0	1103.0	COG0841@1|root,COG0841@2|Bacteria,3Y2RX@57723|Acidobacteria,2JIU0@204432|Acidobacteriia	204432|Acidobacteriia	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TLS2_k127_7396690_1	530564.Psta_0329	2.932e-126	417.0	COG0205@1|root,COG0205@2|Bacteria,2IX8A@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfk	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K00895	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
TLS2_k127_7396690_6	859657.RPSI07_2290	4.529e-12	77.0	COG3631@1|root,COG3631@2|Bacteria,1NBTW@1224|Proteobacteria,2WE9Y@28216|Betaproteobacteria,1KFUS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
TLS2_k127_7396690_0	1267535.KB906767_gene5191	2.472e-149	482.0	COG0577@1|root,COG0577@2|Bacteria,3Y3ZQ@57723|Acidobacteria,2JHMD@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_7396690_3	1267535.KB906767_gene5190	2.391e-76	265.0	COG0457@1|root,COG0457@2|Bacteria,3Y4RD@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
TLS2_k127_7396690_2	1340493.JNIF01000003_gene3076	3.416e-117	390.0	COG0457@1|root,COG0457@2|Bacteria,3Y3BD@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TPR_11,TPR_16,TPR_2,TPR_8
TLS2_k127_7396690_5	234267.Acid_6403	7.45e-14	76.0	COG3350@1|root,COG3350@2|Bacteria,3Y90F@57723|Acidobacteria	57723|Acidobacteria	S	monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7396690_4	643562.Daes_2948	2.064e-25	109.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,2MA96@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Glycosyl transferase, family 20	otsAB	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,S6PP,Trehalose_PPase
TLS2_k127_7402381_3	765911.Thivi_1478	2.366e-05	51.0	COG2336@1|root,COG2336@2|Bacteria,1N7UD@1224|Proteobacteria,1T4ID@1236|Gammaproteobacteria,1WZMG@135613|Chromatiales	135613|Chromatiales	T	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7402381_0	234267.Acid_6059	2.064e-253	789.0	COG4584@1|root,COG4584@2|Bacteria,3Y630@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_7402381_1	234267.Acid_7619	9.125e-128	411.0	COG1484@1|root,COG1484@2|Bacteria,3Y7G6@57723|Acidobacteria	2|Bacteria	L	PFAM IstB domain protein ATP-binding protein	istB3	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21,IstB_IS21_ATP
TLS2_k127_7402381_2	1121106.JQKB01000046_gene3097	1.711e-11	73.0	2E3GJ@1|root,32YFB@2|Bacteria,1R7HZ@1224|Proteobacteria,2U315@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7403082_2	1047013.AQSP01000073_gene1092	6.781e-13	78.0	COG1305@1|root,COG3391@1|root,COG1305@2|Bacteria,COG3391@2|Bacteria,2NQ2D@2323|unclassified Bacteria	2|Bacteria	E	Transglutaminase/protease-like homologues	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Transglut_core
TLS2_k127_7403082_1	1340493.JNIF01000003_gene1813	1.746e-96	333.0	COG3119@1|root,COG3119@2|Bacteria,3Y3PF@57723|Acidobacteria	57723|Acidobacteria	P	PFAM Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_7403082_0	1340493.JNIF01000003_gene2614	1.321e-106	353.0	COG2197@1|root,COG2197@2|Bacteria,3Y669@57723|Acidobacteria	57723|Acidobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_7403082_3	136993.KB900626_gene3360	1.362e-05	51.0	COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2TSY5@28211|Alphaproteobacteria,36YRQ@31993|Methylocystaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA_3,LapD_MoxY_N
TLS2_k127_7421698_1	1144319.PMI16_04662	4.14e-12	76.0	COG0457@1|root,COG0457@2|Bacteria,1PBR1@1224|Proteobacteria	1224|Proteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
TLS2_k127_7421698_0	1267534.KB906757_gene1062	3.68e-82	305.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	1267534.KB906757_gene1062|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7427055_0	1340493.JNIF01000003_gene4600	4.163e-137	447.0	COG1629@1|root,COG4771@2|Bacteria,3Y66U@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_7427055_3	234267.Acid_3128	1.549e-42	172.0	COG3942@1|root,COG3942@2|Bacteria	2|Bacteria	S	pathogenesis	gsp	-	3.5.1.78,6.3.1.8	ko:K01460	ko00480,ko01100,map00480,map01100	-	R01917,R01918	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	Big_2,CHAP,GBS_Bsp-like,GSP_synth
TLS2_k127_7427055_2	1278073.MYSTI_07405	1.402e-110	364.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42ZGK@68525|delta/epsilon subdivisions,2WUTG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_7427055_1	1297742.A176_01177	3.467e-112	368.0	COG1682@1|root,COG1682@2|Bacteria,1QXTH@1224|Proteobacteria,42XN1@68525|delta/epsilon subdivisions,2WSPR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_7427055_4	234267.Acid_0374	2.212e-16	84.0	COG4113@1|root,COG4113@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_7427055_5	1299327.I546_5558	8.339e-06	49.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,23B0M@1762|Mycobacteriaceae	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
TLS2_k127_744661_3	234267.Acid_3982	2.431e-107	351.0	COG2084@1|root,COG2084@2|Bacteria,3Y45W@57723|Acidobacteria	57723|Acidobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_744661_4	234267.Acid_0021	1.09e-54	212.0	COG2202@1|root,COG3290@1|root,COG4251@1|root,COG5002@1|root,COG5278@1|root,COG2202@2|Bacteria,COG3290@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,COG5278@2|Bacteria,3Y99J@57723|Acidobacteria	57723|Acidobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS_4,PAS_9
TLS2_k127_744661_0	234267.Acid_1309	4.046e-206	644.0	COG1060@1|root,COG1060@2|Bacteria,3Y331@57723|Acidobacteria	57723|Acidobacteria	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
TLS2_k127_744661_1	234267.Acid_1310	1.003e-123	403.0	COG0382@1|root,COG0382@2|Bacteria,3Y3CW@57723|Acidobacteria	57723|Acidobacteria	H	PFAM UbiA prenyltransferase	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TLS2_k127_744661_5	1340493.JNIF01000003_gene3503	2.325e-35	140.0	COG1430@1|root,COG1430@2|Bacteria,3Y958@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterized ACR, COG1430	-	-	-	-	-	-	-	-	-	-	-	-	DUF192
TLS2_k127_744661_2	234267.Acid_7127	1.106e-117	389.0	COG1691@1|root,COG1691@2|Bacteria,3Y3BX@57723|Acidobacteria	57723|Acidobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
TLS2_k127_744661_6	572544.Ilyop_0217	9.498e-27	116.0	COG1396@1|root,COG3837@1|root,COG1396@2|Bacteria,COG3837@2|Bacteria,378CF@32066|Fusobacteria	32066|Fusobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
TLS2_k127_7447637_6	435590.BVU_0176	1.561e-55	219.0	COG3401@1|root,COG3401@2|Bacteria,4NFM5@976|Bacteroidetes,2FPSM@200643|Bacteroidia,4ANKU@815|Bacteroidaceae	976|Bacteroidetes	S	candidate rhamnogalacturonan lyase, polysaccharide lyase family 11 protein K01238	-	-	4.2.2.23	ko:K18197	-	-	-	-	ko00000,ko01000	-	PL11	-	-
TLS2_k127_7447637_7	1500894.JQNN01000001_gene887	1.497e-29	137.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,2VPHG@28216|Betaproteobacteria,473WQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	prkC1	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Pkinase,SHOCT
TLS2_k127_7447637_2	1267535.KB906767_gene1157	5.641e-139	447.0	COG0540@1|root,COG0540@2|Bacteria,3Y3KK@57723|Acidobacteria,2JIUN@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_7447637_1	1267535.KB906767_gene1158	8.88e-194	614.0	COG0044@1|root,COG0044@2|Bacteria,3Y34R@57723|Acidobacteria,2JIA3@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS2_k127_7447637_0	234267.Acid_6445	0.0	1056.0	COG1615@1|root,COG1615@2|Bacteria,3Y6XA@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
TLS2_k127_7447637_3	1123278.KB893609_gene4498	1.661e-97	332.0	COG0300@1|root,COG0300@2|Bacteria,4NGDI@976|Bacteroidetes,47JNW@768503|Cytophagia	976|Bacteroidetes	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_7447637_8	671143.DAMO_1089	6.339e-08	61.0	2C5EY@1|root,32YQJ@2|Bacteria,2NREI@2323|unclassified Bacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
TLS2_k127_7447637_5	1340493.JNIF01000003_gene1413	5.276e-81	273.0	COG0693@1|root,COG0693@2|Bacteria	2|Bacteria	S	protein deglycation	pfpI	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
TLS2_k127_7447637_4	1340493.JNIF01000003_gene1412	3.899e-82	277.0	COG1131@1|root,COG1131@2|Bacteria,3Y4CW@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_7460280_2	1267535.KB906767_gene3468	2.016e-207	662.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,3Y2RB@57723|Acidobacteria,2JIRW@204432|Acidobacteriia	204432|Acidobacteriia	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1,ECH_2
TLS2_k127_7460280_1	234267.Acid_6540	9.979e-253	787.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_7460280_0	1340493.JNIF01000003_gene3032	0.0	1146.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_7460280_3	1267535.KB906767_gene808	2.587e-127	420.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_7460280_4	886293.Sinac_1008	1.892e-113	383.0	COG0673@1|root,COG0673@2|Bacteria,2IX39@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_7460280_5	1267535.KB906767_gene1291	1.942e-65	234.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	4.2.1.118,4.2.1.44	ko:K03335,ko:K15652	ko00400,ko00562,ko01100,ko01110,ko01120,ko01130,map00400,map00562,map01100,map01110,map01120,map01130	-	R01627,R02782,R05659	RC00568,RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_7468694_1	234267.Acid_1041	5.042e-30	121.0	COG0720@1|root,COG0720@2|Bacteria,3Y4HE@57723|Acidobacteria	57723|Acidobacteria	H	PFAM 6-pyruvoyl tetrahydropterin	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
TLS2_k127_7468694_0	391615.ABSJ01000037_gene836	5.87e-207	663.0	COG4644@1|root,COG4644@2|Bacteria,1MUIU@1224|Proteobacteria,1RPZZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_Tn3,DUF4158
TLS2_k127_7471326_0	234267.Acid_6153	0.0	1050.0	COG1629@1|root,COG4771@2|Bacteria,3Y9B2@57723|Acidobacteria	57723|Acidobacteria	M	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_7471326_1	234267.Acid_5013	1.406e-88	294.0	COG2192@1|root,COG2192@2|Bacteria,3Y6AX@57723|Acidobacteria	57723|Acidobacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TLS2_k127_749132_0	309807.SRU_2724	8.448e-37	155.0	COG1073@1|root,COG1073@2|Bacteria,4NFRN@976|Bacteroidetes,1FJSE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	BAAT_C,Hydrolase_4
TLS2_k127_750060_0	1267535.KB906767_gene1889	0.0	1393.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,3Y2P5@57723|Acidobacteria,2JMA3@204432|Acidobacteriia	204432|Acidobacteriia	G	PEP-utilising enzyme, mobile domain	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS2_k127_750060_1	1340493.JNIF01000003_gene3552	5.63e-228	725.0	COG0751@1|root,COG0751@2|Bacteria,3Y3KN@57723|Acidobacteria	57723|Acidobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
TLS2_k127_750060_2	234267.Acid_7206	1.78e-153	488.0	COG0752@1|root,COG0752@2|Bacteria,3Y3QC@57723|Acidobacteria	57723|Acidobacteria	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
TLS2_k127_750060_3	1267535.KB906767_gene1892	3.255e-65	229.0	COG1381@1|root,COG1381@2|Bacteria,3Y4AX@57723|Acidobacteria,2JJ0T@204432|Acidobacteriia	204432|Acidobacteriia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
TLS2_k127_750060_4	1163398.AJJP01000169_gene1153	5.25e-51	199.0	COG4928@1|root,COG4928@2|Bacteria	2|Bacteria	G	KAP family P-loop domain	-	-	-	-	-	-	-	-	-	-	-	-	KAP_NTPase
TLS2_k127_753318_5	234267.Acid_6424	3.814e-68	240.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,3Y3VQ@57723|Acidobacteria	57723|Acidobacteria	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
TLS2_k127_753318_4	1267535.KB906767_gene4335	2.907e-83	284.0	2F1JK@1|root,33UK0@2|Bacteria,3Y7KY@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_753318_3	1415779.JOMH01000001_gene2653	1.292e-98	329.0	COG0614@1|root,COG0614@2|Bacteria,1PK1A@1224|Proteobacteria,1RRDK@1236|Gammaproteobacteria,1X3UZ@135614|Xanthomonadales	135614|Xanthomonadales	P	ABC transporter substrate-binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS2_k127_753318_2	1038859.AXAU01000016_gene6869	1.496e-108	371.0	COG0654@1|root,COG0654@2|Bacteria,1QWT3@1224|Proteobacteria,2U2GE@28211|Alphaproteobacteria,3JZXS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS2_k127_753318_6	234267.Acid_4942	1.602e-56	203.0	COG0352@1|root,COG0352@2|Bacteria,3Y4Y5@57723|Acidobacteria	57723|Acidobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TLS2_k127_753318_1	234267.Acid_4943	3.862e-192	610.0	COG0531@1|root,COG0531@2|Bacteria,3Y3QM@57723|Acidobacteria	57723|Acidobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_753318_0	1267535.KB906767_gene2140	8.693e-205	648.0	COG0531@1|root,COG0531@2|Bacteria,3Y3SZ@57723|Acidobacteria,2JI7T@204432|Acidobacteriia	204432|Acidobacteriia	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_753318_7	1173026.Glo7428_3606	4.548e-35	151.0	COG5563@1|root,COG5563@2|Bacteria,1GASM@1117|Cyanobacteria	1117|Cyanobacteria	S	Extracellular repeat protein, HAF family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3466
TLS2_k127_753318_8	28532.XP_010520862.1	3.954e-09	62.0	COG0471@1|root,2QQ8W@2759|Eukaryota,37P5Y@33090|Viridiplantae,3GAVS@35493|Streptophyta,3HMZP@3699|Brassicales	35493|Streptophyta	P	Dicarboxylate transporter 2.1	-	GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005313,GO:0005326,GO:0005342,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006541,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0009064,GO:0009507,GO:0009526,GO:0009534,GO:0009536,GO:0009579,GO:0009605,GO:0009607,GO:0009624,GO:0009941,GO:0009987,GO:0015075,GO:0015131,GO:0015140,GO:0015171,GO:0015172,GO:0015179,GO:0015238,GO:0015318,GO:0015556,GO:0015711,GO:0015729,GO:0015740,GO:0015743,GO:0015800,GO:0015807,GO:0015813,GO:0015849,GO:0015893,GO:0016020,GO:0019676,GO:0019740,GO:0019752,GO:0022857,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0034220,GO:0042221,GO:0042493,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0051704,GO:0051707,GO:0055085,GO:0071423,GO:0071702,GO:0071704,GO:0071705,GO:0098656,GO:1901564,GO:1901605,GO:1902356,GO:1902475,GO:1903825,GO:1905039	-	ko:K03319	-	-	-	-	ko00000	2.A.47	-	-	Na_sulph_symp
TLS2_k127_753318_9	1340493.JNIF01000003_gene3950	2.514e-07	55.0	COG0471@1|root,COG0471@2|Bacteria,3Y6TC@57723|Acidobacteria	57723|Acidobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K03319	-	-	-	-	ko00000	2.A.47	-	-	Na_sulph_symp
TLS2_k127_758807_2	1116472.MGMO_8c00260	1.587e-10	63.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1S0QX@1236|Gammaproteobacteria,1XGCX@135618|Methylococcales	135618|Methylococcales	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_758807_3	1313265.JNIE01000002_gene1055	1.036e-05	54.0	COG2204@1|root,COG2204@2|Bacteria,2G3HZ@200783|Aquificae	200783|Aquificae	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_758807_0	1340493.JNIF01000004_gene1015	2.488e-179	579.0	COG4805@1|root,COG4805@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS2_k127_758807_1	1340493.JNIF01000003_gene4723	6.577e-63	220.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	3.1.6.1,3.1.6.8	ko:K01130,ko:K01134	ko00140,ko00600,ko04142,map00140,map00600,map04142	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF4976,Sulfatase
TLS2_k127_762121_2	1340493.JNIF01000003_gene2023	8.947e-133	441.0	COG1450@1|root,COG1450@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	gspD	-	-	ko:K02453,ko:K03219	ko03070,ko05111,map03070,map05111	M00331,M00332,M00542	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15,3.A.6.1,3.A.6.3	-	-	Secretin,Secretin_N
TLS2_k127_762121_3	234267.Acid_7785	1.095e-112	380.0	COG4972@1|root,COG4972@2|Bacteria	2|Bacteria	NU	Pilus assembly protein	-	-	-	ko:K02461,ko:K02662	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15	-	-	PilM_2,PilN,T2SSL
TLS2_k127_762121_4	234267.Acid_7784	1.24e-70	251.0	COG3156@1|root,COG3156@2|Bacteria	2|Bacteria	U	protein secretion	-	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
TLS2_k127_762121_9	234267.Acid_7782	2.849e-33	138.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	CP_1053	-	-	ko:K02456,ko:K02458,ko:K02459,ko:K10927	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
TLS2_k127_762121_7	234267.Acid_7780	4.964e-52	190.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	gspG	-	-	ko:K02246,ko:K02456,ko:K02458	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
TLS2_k127_762121_0	234267.Acid_7779	2.507e-169	540.0	COG1459@1|root,COG1459@2|Bacteria,3Y48Z@57723|Acidobacteria	57723|Acidobacteria	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
TLS2_k127_762121_1	566466.NOR53_250	1.334e-146	482.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1J57U@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	secretory pathway	xpsE	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
TLS2_k127_762121_6	234267.Acid_7775	3.003e-58	205.0	COG1595@1|root,COG1595@2|Bacteria,3Y7WY@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_76441_1	977880.RALTA_A2677	6.783e-06	49.0	COG2350@1|root,COG2350@2|Bacteria,1NHP3@1224|Proteobacteria,2VWVS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
TLS2_k127_76441_0	1007104.SUS17_366	1.672e-182	590.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSUQ@28211|Alphaproteobacteria,2K0GU@204457|Sphingomonadales	204457|Sphingomonadales	O	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS2_k127_765231_2	234267.Acid_1442	1.651e-16	91.0	COG0642@1|root,COG2205@2|Bacteria	234267.Acid_1442|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_765231_0	452637.Oter_0756	1.689e-122	404.0	COG1835@1|root,COG1835@2|Bacteria,46VHV@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS2_k127_765231_1	1123242.JH636434_gene3868	2.67e-80	285.0	COG1520@1|root,COG1520@2|Bacteria,2IYRB@203682|Planctomycetes	1123242.JH636434_gene3868|-	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_770313_0	1340493.JNIF01000003_gene1952	0.0	1259.0	COG0841@1|root,COG0841@2|Bacteria,3Y6DS@57723|Acidobacteria	57723|Acidobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran,OEP
TLS2_k127_770313_3	1340493.JNIF01000003_gene1953	1.239e-99	342.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TLS2_k127_770313_6	234267.Acid_0413	7.115e-49	181.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	MA20_16815	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
TLS2_k127_770313_5	365046.Rta_14990	6.752e-83	297.0	28P7U@1|root,2ZC21@2|Bacteria,1NTJA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_770313_1	1340493.JNIF01000003_gene2245	6.526e-173	553.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS2_k127_770313_4	234267.Acid_2633	5.974e-85	292.0	COG1957@1|root,COG1957@2|Bacteria,3Y6U8@57723|Acidobacteria	57723|Acidobacteria	F	Inosine-uridine preferring nucleoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	IU_nuc_hydro
TLS2_k127_770313_7	1118153.MOY_13059	0.0009869	44.0	COG1715@1|root,COG1715@2|Bacteria,1Q2VY@1224|Proteobacteria,1RYEE@1236|Gammaproteobacteria,1XKZD@135619|Oceanospirillales	135619|Oceanospirillales	V	restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_N,Mrr_cat
TLS2_k127_770313_2	639030.JHVA01000001_gene1877	4.495e-168	558.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_771718_0	234267.Acid_0139	2.493e-212	696.0	COG3485@1|root,COG3485@2|Bacteria	234267.Acid_0139|-	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_771718_1	234267.Acid_0138	6.108e-57	218.0	COG3806@1|root,COG3806@2|Bacteria,3Y5HQ@57723|Acidobacteria	57723|Acidobacteria	T	Anti-sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_772524_1	234267.Acid_1203	4.184e-88	311.0	COG1732@1|root,COG1732@2|Bacteria,3Y3Z9@57723|Acidobacteria	57723|Acidobacteria	M	ABC-type glycine betaine transport system	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
TLS2_k127_772524_2	234267.Acid_1204	3.21e-77	265.0	COG1174@1|root,COG1174@2|Bacteria	2|Bacteria	P	glycine betaine transport	-	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
TLS2_k127_772524_0	1165094.RINTHH_14950	6.027e-89	302.0	COG1125@1|root,COG1125@2|Bacteria,1G21Q@1117|Cyanobacteria,1HIQ3@1161|Nostocales	1117|Cyanobacteria	E	ABC-type proline glycine betaine transport	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
TLS2_k127_772524_3	945713.IALB_0988	1.412e-56	199.0	COG2978@1|root,COG2978@2|Bacteria	2|Bacteria	H	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity	ydaH	-	-	ko:K12942	-	-	-	-	ko00000	-	-	-	ABG_transport
TLS2_k127_775261_1	1173024.KI912149_gene6039	1.053e-32	128.0	COG3514@1|root,COG3514@2|Bacteria,1G7ND@1117|Cyanobacteria	1117|Cyanobacteria	S	SPTR CopG domain protein DNA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BrnA_antitoxin
TLS2_k127_775261_0	1121272.KB903249_gene2239	3.91e-100	336.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4DB8J@85008|Micromonosporales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
TLS2_k127_775261_2	861299.J421_2273	1.168e-21	97.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_78602_0	502025.Hoch_2978	5.062e-135	446.0	28N8D@1|root,2ZBCT@2|Bacteria,1R0N1@1224|Proteobacteria,43CYK@68525|delta/epsilon subdivisions,2X86R@28221|Deltaproteobacteria,2Z04G@29|Myxococcales	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_78602_2	177437.HRM2_05840	9.985e-93	313.0	29CPA@1|root,2ZZMJ@2|Bacteria,1QWMK@1224|Proteobacteria,43BCF@68525|delta/epsilon subdivisions,2X6RE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
TLS2_k127_78602_1	1144664.F973_02865	1.263e-121	394.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,3NJEF@468|Moraxellaceae	1236|Gammaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
TLS2_k127_791959_1	401526.TcarDRAFT_1449	4.818e-63	229.0	COG1099@1|root,COG1099@2|Bacteria,1V5KM@1239|Firmicutes,4H4YQ@909932|Negativicutes	909932|Negativicutes	S	with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_791959_0	234267.Acid_3870	4.717e-117	380.0	COG0673@1|root,COG0673@2|Bacteria,3Y6Q3@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_793810_1	1121374.KB891575_gene1106	2.815e-05	49.0	COG2304@1|root,COG2304@2|Bacteria,1RIXD@1224|Proteobacteria,1S6EY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
TLS2_k127_793810_0	1267535.KB906767_gene4787	0.0	1318.0	COG0209@1|root,COG0209@2|Bacteria,3Y3Q1@57723|Acidobacteria,2JITI@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
TLS2_k127_801872_0	1340493.JNIF01000004_gene614	9.754e-217	679.0	COG0673@1|root,COG0673@2|Bacteria,3Y3V4@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_801872_1	234267.Acid_2691	1.356e-172	550.0	COG0673@1|root,COG0673@2|Bacteria,3Y3V4@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_801872_2	234267.Acid_1558	4.735e-91	306.0	COG1063@1|root,COG1063@2|Bacteria,3Y7C5@57723|Acidobacteria	57723|Acidobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
TLS2_k127_806324_2	1210908.HSB1_36260	0.0001508	50.0	COG0589@1|root,arCOG02053@2157|Archaea,2XXRS@28890|Euryarchaeota,23W7D@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_806324_3	1296416.JACB01000001_gene3358	0.0007844	42.0	COG0589@1|root,COG0589@2|Bacteria,4NJ0H@976|Bacteroidetes,1I0HV@117743|Flavobacteriia,2YKRI@290174|Aquimarina	976|Bacteroidetes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_806324_1	243231.GSU0260	5.002e-06	50.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	ko:K06149	-	-	-	-	ko00000	-	-	-	Usp
TLS2_k127_806324_0	926560.KE387023_gene3681	1.651e-255	803.0	COG0474@1|root,COG0474@2|Bacteria,1WICW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.6,3.6.3.8	ko:K01535,ko:K01537	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.2,3.A.3.3	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS2_k127_807356_16	1340493.JNIF01000003_gene3227	3.471e-18	87.0	COG0201@1|root,COG0201@2|Bacteria,3Y38D@57723|Acidobacteria	57723|Acidobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
TLS2_k127_807356_7	1267535.KB906767_gene2686	1.891e-55	197.0	COG0200@1|root,COG0200@2|Bacteria,3Y4JC@57723|Acidobacteria,2JJ94@204432|Acidobacteriia	204432|Acidobacteriia	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
TLS2_k127_807356_15	1267535.KB906767_gene2687	1.29e-18	94.0	COG1841@1|root,COG1841@2|Bacteria,3Y5I2@57723|Acidobacteria	57723|Acidobacteria	J	Ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
TLS2_k127_807356_3	1267535.KB906767_gene2688	3.292e-80	269.0	COG0098@1|root,COG0098@2|Bacteria,3Y2FE@57723|Acidobacteria,2JHKR@204432|Acidobacteriia	204432|Acidobacteriia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
TLS2_k127_807356_10	234267.Acid_5102	2.251e-47	172.0	COG0256@1|root,COG0256@2|Bacteria,3Y5CH@57723|Acidobacteria	57723|Acidobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
TLS2_k127_807356_2	1340493.JNIF01000003_gene3222	2.637e-87	291.0	COG0097@1|root,COG0097@2|Bacteria,3Y496@57723|Acidobacteria	57723|Acidobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
TLS2_k127_807356_6	234267.Acid_5104	1.031e-61	216.0	COG0096@1|root,COG0096@2|Bacteria,3Y4IE@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
TLS2_k127_807356_14	234267.Acid_5105	3.986e-22	97.0	COG0199@1|root,COG0199@2|Bacteria,3Y5HM@57723|Acidobacteria	57723|Acidobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
TLS2_k127_807356_1	1267535.KB906767_gene2692	9.878e-89	295.0	COG0094@1|root,COG0094@2|Bacteria,3Y3PS@57723|Acidobacteria,2JHV4@204432|Acidobacteriia	204432|Acidobacteriia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
TLS2_k127_807356_12	1340493.JNIF01000003_gene3218	6.075e-41	153.0	COG0198@1|root,COG0198@2|Bacteria,3Y56T@57723|Acidobacteria	57723|Acidobacteria	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
TLS2_k127_807356_5	1267535.KB906767_gene2694	2.214e-63	224.0	COG0093@1|root,COG0093@2|Bacteria,3Y4N0@57723|Acidobacteria,2JJ86@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
TLS2_k127_807356_13	1267535.KB906767_gene2695	1.001e-34	136.0	COG0186@1|root,COG0186@2|Bacteria,3Y5I3@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
TLS2_k127_807356_17	1340493.JNIF01000003_gene3215	1.564e-14	85.0	COG0255@1|root,COG0255@2|Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
TLS2_k127_807356_4	682795.AciX8_0580	3.224e-70	239.0	COG0197@1|root,COG0197@2|Bacteria,3Y4EG@57723|Acidobacteria,2JJ2G@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
TLS2_k127_807356_0	234267.Acid_5112	1.703e-133	432.0	COG0092@1|root,COG0092@2|Bacteria,3Y3ZN@57723|Acidobacteria	57723|Acidobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
TLS2_k127_807356_8	234267.Acid_5113	1.997e-51	187.0	COG0091@1|root,COG0091@2|Bacteria,3Y4KH@57723|Acidobacteria	57723|Acidobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
TLS2_k127_807356_11	1340493.JNIF01000003_gene3211	4.581e-43	158.0	COG0185@1|root,COG0185@2|Bacteria,3Y560@57723|Acidobacteria	57723|Acidobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
TLS2_k127_807356_9	1267535.KB906767_gene2701	2.155e-51	182.0	COG0090@1|root,COG0090@2|Bacteria,3Y3DH@57723|Acidobacteria,2JI2K@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
TLS2_k127_811486_12	996637.SGM_0083	4.411e-29	118.0	COG0346@1|root,COG0346@2|Bacteria,2IKTR@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_811486_8	1267534.KB906758_gene2365	2.475e-66	231.0	2DKVG@1|root,30GRY@2|Bacteria,3Y4H8@57723|Acidobacteria,2JJAT@204432|Acidobacteriia	204432|Acidobacteriia	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
TLS2_k127_811486_6	204669.Acid345_4589	3.461e-75	258.0	COG2353@1|root,COG2353@2|Bacteria,3Y4PV@57723|Acidobacteria,2JMQH@204432|Acidobacteriia	204432|Acidobacteriia	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
TLS2_k127_811486_1	1267533.KB906733_gene3183	1.845e-153	494.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
TLS2_k127_811486_14	1121405.dsmv_3744	5.449e-05	52.0	2FIEC@1|root,34A6J@2|Bacteria,1NZYM@1224|Proteobacteria,431P9@68525|delta/epsilon subdivisions,2WWA8@28221|Deltaproteobacteria,2MNXJ@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_811486_2	234267.Acid_0648	1.682e-107	361.0	COG1475@1|root,COG1475@2|Bacteria,3Y7ZH@57723|Acidobacteria	57723|Acidobacteria	K	ParB-like nuclease domain	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
TLS2_k127_811486_3	234267.Acid_0647	1.792e-91	311.0	COG4584@1|root,COG4584@2|Bacteria,3Y6WU@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_811486_11	522306.CAP2UW1_1455	2.236e-29	130.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VJJ7@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_811486_5	234267.Acid_0646	4.36e-82	275.0	COG1484@1|root,COG1484@2|Bacteria,3Y6NW@57723|Acidobacteria	57723|Acidobacteria	L	Bacterial dnaA  protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
TLS2_k127_811486_7	1255043.TVNIR_0913	4.121e-70	254.0	COG4974@1|root,COG4974@2|Bacteria,1QUHS@1224|Proteobacteria,1S2C4@1236|Gammaproteobacteria,1X0IU@135613|Chromatiales	135613|Chromatiales	L	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_811486_4	1117958.PE143B_0100130	6.595e-83	290.0	COG0582@1|root,COG0582@2|Bacteria,1NX90@1224|Proteobacteria,1SDT1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_811486_0	234267.Acid_6799	1.21e-181	572.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_811486_9	234267.Acid_0646	3.901e-37	140.0	COG1484@1|root,COG1484@2|Bacteria,3Y6NW@57723|Acidobacteria	57723|Acidobacteria	L	Bacterial dnaA  protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
TLS2_k127_811486_13	1340493.JNIF01000003_gene4842	6.158e-17	86.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,3Y5S6@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
TLS2_k127_815268_1	765910.MARPU_11415	3.405e-68	237.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,1RPYF@1236|Gammaproteobacteria,1WX5H@135613|Chromatiales	135613|Chromatiales	P	pfam abc-3	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
TLS2_k127_815268_2	1260251.SPISAL_07090	1.843e-20	93.0	COG2835@1|root,COG2835@2|Bacteria,1P6IM@1224|Proteobacteria,1SV7D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
TLS2_k127_815268_0	760192.Halhy_2525	4.149e-111	363.0	COG0388@1|root,COG0388@2|Bacteria,4NEAQ@976|Bacteroidetes,1IPV0@117747|Sphingobacteriia	976|Bacteroidetes	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	ramA_2	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
TLS2_k127_830463_3	313612.L8106_11567	3.003e-49	184.0	COG2303@1|root,COG2303@2|Bacteria,1G31H@1117|Cyanobacteria,1HH93@1150|Oscillatoriales	1117|Cyanobacteria	E	Gmc oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GIDA,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
TLS2_k127_830463_1	234267.Acid_3293	9.541e-81	275.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	yjoA	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
TLS2_k127_830463_4	234267.Acid_4822	2.295e-34	143.0	COG0741@1|root,COG0741@2|Bacteria	2|Bacteria	M	lytic transglycosylase activity	ltg	-	-	-	-	-	-	-	-	-	-	-	SLT
TLS2_k127_830463_6	1211114.ALIP01000120_gene1016	9.037e-13	73.0	COG1516@1|root,COG1516@2|Bacteria,1MZ3G@1224|Proteobacteria,1S8TQ@1236|Gammaproteobacteria,1X6ZI@135614|Xanthomonadales	135614|Xanthomonadales	N	flagellar protein FliS	fliS	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
TLS2_k127_830463_5	234267.Acid_7449	1.601e-13	78.0	COG3951@1|root,COG3951@2|Bacteria,3Y8ZC@57723|Acidobacteria	57723|Acidobacteria	MNO	Rod binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Rod-binding
TLS2_k127_830463_0	234267.Acid_7450	2.96e-139	456.0	COG1706@1|root,COG1706@2|Bacteria,3Y2UQ@57723|Acidobacteria	57723|Acidobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
TLS2_k127_830463_2	234267.Acid_7451	1.717e-54	199.0	COG2063@1|root,COG2063@2|Bacteria,3Y3D6@57723|Acidobacteria	57723|Acidobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	-	-	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
TLS2_k127_830463_7	234267.Acid_7452	1.003e-05	51.0	COG1261@1|root,COG1261@2|Bacteria,3Y8G9@57723|Acidobacteria	57723|Acidobacteria	NO	Chaperone for flagella basal body P-ring formation	-	-	-	ko:K02386	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	ChapFlgA
TLS2_k127_833153_3	234267.Acid_7932	8.348e-31	124.0	COG0613@1|root,COG0613@2|Bacteria,3Y5C1@57723|Acidobacteria	57723|Acidobacteria	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
TLS2_k127_833153_1	1267535.KB906767_gene2144	6.731e-74	262.0	COG0354@1|root,COG0354@2|Bacteria,3Y2PI@57723|Acidobacteria,2JJ3H@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
TLS2_k127_833153_0	234267.Acid_7929	5.607e-97	320.0	COG0491@1|root,COG0491@2|Bacteria,3Y4DN@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_833153_4	1218173.BALCAV_0215385	1.056e-15	81.0	COG2223@1|root,COG2223@2|Bacteria,1TRS9@1239|Firmicutes,4HCY1@91061|Bacilli,1ZBQH@1386|Bacillus	91061|Bacilli	P	COG2223 Nitrate nitrite transporter	nasA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	iYO844.BSU03330	MFS_1
TLS2_k127_833153_2	1906.SFRA_02415	1.694e-72	260.0	COG1404@1|root,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,P_proprotein,Peptidase_S8
TLS2_k127_833153_6	1449080.JQMV01000003_gene504	1.146e-06	57.0	2DR9X@1|root,33AUW@2|Bacteria,1WJ2Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PrcB C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PrcB_C
TLS2_k127_833153_5	234267.Acid_5498	1.256e-14	75.0	COG2363@1|root,COG2363@2|Bacteria,3Y82H@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF423)	-	-	-	-	-	-	-	-	-	-	-	-	DUF423
TLS2_k127_834507_1	1385519.N801_16220	6.677e-39	155.0	COG1266@1|root,COG1266@2|Bacteria,2IAIM@201174|Actinobacteria	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS2_k127_834507_3	309807.SRU_2815	4.147e-09	63.0	COG2336@1|root,COG2336@2|Bacteria	2|Bacteria	T	PFAM SpoVT AbrB	-	-	-	ko:K07172,ko:K18842	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
TLS2_k127_834507_2	278963.ATWD01000001_gene2995	6.97e-27	113.0	COG3654@1|root,COG3654@2|Bacteria,3Y5NN@57723|Acidobacteria,2JJXW@204432|Acidobacteriia	204432|Acidobacteriia	S	Fic/DOC family	-	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
TLS2_k127_834507_0	82654.Pse7367_1434	1.266e-103	349.0	COG0640@1|root,COG3177@1|root,COG0640@2|Bacteria,COG3177@2|Bacteria,1G3Q5@1117|Cyanobacteria,1H88N@1150|Oscillatoriales	1117|Cyanobacteria	K	filamentation induced by cAMP protein Fic	-	-	-	-	-	-	-	-	-	-	-	-	DUF4172,Fic,Fic_N
TLS2_k127_837743_6	99598.Cal7507_3732	6.561e-30	119.0	COG1652@1|root,COG1652@2|Bacteria	2|Bacteria	S	positive regulation of growth rate	ygaU	GO:0003674,GO:0005488,GO:0008150,GO:0010035,GO:0010038,GO:0030955,GO:0031420,GO:0035864,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896	-	-	-	-	-	-	-	-	-	-	BON,LysM
TLS2_k127_837743_2	1121403.AUCV01000028_gene2420	4.394e-144	466.0	COG3500@1|root,COG3500@2|Bacteria,1Q2U5@1224|Proteobacteria,42UA7@68525|delta/epsilon subdivisions,2WQM0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Late control gene D protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
TLS2_k127_837743_4	670292.JH26_09715	1.721e-81	274.0	COG3501@1|root,COG3501@2|Bacteria,1R540@1224|Proteobacteria,2U1BE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_837743_5	1117108.PAALTS15_18198	7.294e-42	156.0	2CE1N@1|root,32RYY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_837743_7	114615.BRADO4378	3.9e-25	113.0	COG3628@1|root,COG3628@2|Bacteria,1N039@1224|Proteobacteria,2UF36@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Gene 25-like lysozyme	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
TLS2_k127_837743_0	102129.Lepto7375DRAFT_2529	6.584e-256	814.0	COG3299@1|root,COG3299@2|Bacteria,1G3VV@1117|Cyanobacteria,1H9UA@1150|Oscillatoriales	1117|Cyanobacteria	S	protein, phage tail-like region	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
TLS2_k127_837743_1	1122599.AUGR01000019_gene3063	2.087e-189	643.0	COG2375@1|root,COG2375@2|Bacteria,1QWF4@1224|Proteobacteria,1T59S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
TLS2_k127_837743_3	330214.NIDE2237	1.513e-100	349.0	COG3292@1|root,COG3292@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,Tail_P2_I
TLS2_k127_84616_2	1340493.JNIF01000003_gene4033	1.487e-88	297.0	COG0577@1|root,COG0577@2|Bacteria,3Y3XI@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_84616_1	234267.Acid_5982	7.572e-144	468.0	COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_84616_0	1267535.KB906767_gene3187	3.397e-296	937.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,CarbopepD_reg_2,Plug
TLS2_k127_860775_1	1340493.JNIF01000004_gene1030	2.107e-175	563.0	COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_7,Molydop_binding
TLS2_k127_860775_0	1340493.JNIF01000004_gene1031	1.403e-226	713.0	COG5557@1|root,COG5557@2|Bacteria,3Y3NS@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
TLS2_k127_860775_4	1340493.JNIF01000004_gene1032	1.032e-62	225.0	COG2010@1|root,COG2010@2|Bacteria,3Y3HF@57723|Acidobacteria	57723|Acidobacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,DUF3341
TLS2_k127_860775_3	1267535.KB906767_gene1097	8.414e-74	254.0	COG2010@1|root,COG2010@2|Bacteria,3Y2MN@57723|Acidobacteria,2JI6T@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS2_k127_860775_2	1340493.JNIF01000004_gene1034	7.264e-145	473.0	COG4531@1|root,COG4531@2|Bacteria,3Y2X7@57723|Acidobacteria	57723|Acidobacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_860775_5	1267535.KB906767_gene1095	8.657e-16	86.0	2EJZ3@1|root,33DPP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_861045_0	1340493.JNIF01000003_gene3565	4.358e-245	781.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_861045_1	1089553.Tph_c09100	8.577e-93	321.0	COG0407@1|root,COG0407@2|Bacteria,1TRJG@1239|Firmicutes,24B34@186801|Clostridia,42G9W@68295|Thermoanaerobacterales	186801|Clostridia	H	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TLS2_k127_872332_4	234267.Acid_4765	1.603e-06	56.0	COG3801@1|root,COG3801@2|Bacteria,3Y5K2@57723|Acidobacteria	57723|Acidobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
TLS2_k127_872332_3	502025.Hoch_0991	6.14e-12	72.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,4313Z@68525|delta/epsilon subdivisions,2WX2K@28221|Deltaproteobacteria,2Z2QP@29|Myxococcales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_872332_0	1340493.JNIF01000003_gene3746	5.994e-95	331.0	COG1053@1|root,COG1053@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_oxidored,FMN_red,GIDA
TLS2_k127_872332_2	1121346.KB899826_gene420	3.375e-41	166.0	COG1609@1|root,COG1609@2|Bacteria,1TP9Q@1239|Firmicutes,4HARD@91061|Bacilli,26RWZ@186822|Paenibacillaceae	91061|Bacilli	K	GntR family transcriptional regulator	araR	-	-	ko:K02103	-	-	-	-	ko00000,ko03000	-	-	-	GntR,Peripla_BP_3
TLS2_k127_872332_1	1340493.JNIF01000003_gene2166	3.364e-94	330.0	COG1629@1|root,COG4771@2|Bacteria,3Y36T@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_876844_2	1267535.KB906767_gene684	2.949e-64	232.0	COG0477@1|root,COG0477@2|Bacteria,3Y777@57723|Acidobacteria	57723|Acidobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_876844_1	234267.Acid_2609	1.621e-73	264.0	2A5Y1@1|root,30UQ2@2|Bacteria,3Y7MH@57723|Acidobacteria	57723|Acidobacteria	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
TLS2_k127_876844_3	314230.DSM3645_23436	2.388e-31	139.0	COG4785@1|root,COG4785@2|Bacteria,2IZYN@203682|Planctomycetes	203682|Planctomycetes	S	May be involved in cell division	-	-	-	ko:K05803	-	-	-	-	ko00000	-	-	-	TPR_16
TLS2_k127_876844_0	1210884.HG799472_gene14911	2.506e-90	308.0	COG1520@1|root,COG1520@2|Bacteria,2IWXJ@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_897895_1	575540.Isop_3370	4.938e-104	342.0	COG3386@1|root,COG3386@2|Bacteria,2J2MK@203682|Planctomycetes	203682|Planctomycetes	G	BNR repeat-containing family member	-	-	-	-	-	-	-	-	-	-	-	-	BNR_4
TLS2_k127_897895_0	1267535.KB906767_gene4711	5.471e-308	977.0	COG4932@1|root,COG4932@2|Bacteria,3Y6EM@57723|Acidobacteria,2JKUS@204432|Acidobacteriia	204432|Acidobacteriia	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_897895_3	1267535.KB906767_gene4919	1.24e-60	226.0	COG0745@1|root,COG0745@2|Bacteria,3Y67W@57723|Acidobacteria	57723|Acidobacteria	KT	RESPONSE REGULATOR receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_897895_2	234267.Acid_2502	4.744e-73	254.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_897895_4	1267535.KB906767_gene3462	1.87e-54	198.0	COG1437@1|root,COG1437@2|Bacteria,3Y4V3@57723|Acidobacteria	57723|Acidobacteria	F	CYTH	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
TLS2_k127_897895_5	234267.Acid_5771	4.603e-30	124.0	COG2010@1|root,COG2010@2|Bacteria,3Y5Q0@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS2_k127_897895_7	1340493.JNIF01000003_gene4387	9.973e-20	88.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_911599_5	1267535.KB906767_gene4423	8.748e-49	184.0	COG4733@1|root,COG4733@2|Bacteria,3Y53H@57723|Acidobacteria	57723|Acidobacteria	S	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_911599_3	234267.Acid_6425	9.428e-147	470.0	COG2896@1|root,COG2896@2|Bacteria,3Y30D@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
TLS2_k127_911599_2	234267.Acid_6426	5.229e-160	512.0	COG0379@1|root,COG0379@2|Bacteria,3Y328@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
TLS2_k127_911599_7	234267.Acid_4604	1.44e-08	68.0	COG1470@1|root,COG3291@1|root,COG1470@2|Bacteria,COG3291@2|Bacteria,3Y97Z@57723|Acidobacteria	57723|Acidobacteria	G	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
TLS2_k127_911599_4	1210884.HG799469_gene14163	5.752e-116	387.0	COG0666@1|root,COG1520@1|root,COG0666@2|Bacteria,COG1520@2|Bacteria,2J2A4@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TLS2_k127_911599_0	234267.Acid_0432	1.172e-178	572.0	COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria	57723|Acidobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
TLS2_k127_911599_1	234267.Acid_0431	1.739e-176	569.0	COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,3Y6QW@57723|Acidobacteria	57723|Acidobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB
TLS2_k127_926506_9	1340493.JNIF01000004_gene775	1.078e-19	102.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
TLS2_k127_926506_8	1267535.KB906767_gene1491	1.766e-33	133.0	COG2127@1|root,COG2127@2|Bacteria,3Y85A@57723|Acidobacteria	57723|Acidobacteria	S	ATP-dependent Clp protease adaptor protein ClpS	-	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
TLS2_k127_926506_2	1267535.KB906767_gene1317	1.171e-98	329.0	COG1082@1|root,COG1082@2|Bacteria,3Y72F@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_926506_1	234267.Acid_4908	1.468e-100	338.0	COG0673@1|root,COG0673@2|Bacteria,3Y6XR@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_926506_3	1267535.KB906767_gene427	3.687e-81	275.0	2F161@1|root,33U75@2|Bacteria,3Y7M8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_926506_4	1000565.METUNv1_02939	1.371e-76	284.0	COG1629@1|root,COG4771@2|Bacteria,1QTS8@1224|Proteobacteria,2WGGE@28216|Betaproteobacteria	28216|Betaproteobacteria	P	receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TLS2_k127_926506_7	671143.DAMO_1603	3.818e-34	138.0	COG0432@1|root,COG0432@2|Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TLS2_k127_926506_5	234267.Acid_1194	6.069e-40	152.0	COG4911@1|root,COG4911@2|Bacteria,3Y4VB@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
TLS2_k127_926506_0	234267.Acid_2490	7.25e-116	388.0	COG1680@1|root,COG1680@2|Bacteria,3Y3WB@57723|Acidobacteria	57723|Acidobacteria	V	PFAM Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
TLS2_k127_927289_6	234267.Acid_0525	1.521e-18	89.0	COG4798@1|root,COG4798@2|Bacteria	2|Bacteria	E	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,FAD_binding_4,Methyltransf_11,Methyltransf_25,Methyltransf_31,SAM_MT
TLS2_k127_927289_1	497964.CfE428DRAFT_4366	6.308e-159	511.0	COG1520@1|root,COG1520@2|Bacteria,46TRS@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TLS2_k127_927289_2	1123393.KB891316_gene2018	6.668e-143	458.0	28HGI@1|root,2Z7SC@2|Bacteria,1MWKC@1224|Proteobacteria,2VP5Q@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_927289_4	1340493.JNIF01000003_gene4628	4.382e-100	331.0	COG0225@1|root,COG0225@2|Bacteria,3Y33X@57723|Acidobacteria	57723|Acidobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS2_k127_927289_3	1123242.JH636434_gene3868	3.98e-102	348.0	COG1520@1|root,COG1520@2|Bacteria,2IYRB@203682|Planctomycetes	1123242.JH636434_gene3868|-	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_927289_0	234267.Acid_1464	1.557e-170	538.0	2C1EG@1|root,2Z7MZ@2|Bacteria,3Y5JH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_927289_5	269482.Bcep1808_5214	1.427e-33	132.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria,1K3VG@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG2	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
TLS2_k127_927532_0	234267.Acid_4250	2.978e-149	482.0	COG0644@1|root,COG0644@2|Bacteria,3Y5JJ@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Pyr_redox_2
TLS2_k127_927532_2	1173026.Glo7428_3883	1.643e-55	214.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	DICT,DUF3365,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_927532_1	1123508.JH636442_gene3989	2.664e-74	273.0	COG1366@1|root,COG2202@1|root,COG3920@1|root,COG1366@2|Bacteria,COG2202@2|Bacteria,COG3920@2|Bacteria,2J004@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2,PAS_4
TLS2_k127_930922_13	234267.Acid_5658	1.607e-45	183.0	COG0457@1|root,COG0457@2|Bacteria,3Y5YE@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_930922_11	1340493.JNIF01000003_gene2570	5.204e-57	207.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K07000	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,BAAT_C,DUF676,Hydrolase_4
TLS2_k127_930922_7	1340493.JNIF01000003_gene3336	2.822e-81	282.0	COG3595@1|root,COG3595@2|Bacteria,3Y5MS@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_930922_0	234267.Acid_5645	0.0	1756.0	COG1038@1|root,COG1038@2|Bacteria,3Y6UX@57723|Acidobacteria	57723|Acidobacteria	C	Conserved carboxylase domain	-	-	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
TLS2_k127_930922_9	1349767.GJA_3764	1.904e-61	223.0	COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,2VZ36@28216|Betaproteobacteria,472UX@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS2_k127_930922_8	1502852.FG94_04662	3.019e-69	244.0	COG1409@1|root,COG1409@2|Bacteria,1MW6B@1224|Proteobacteria,2VHKF@28216|Betaproteobacteria,472IV@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	Calcineurin-like phosphoesterase superfamily domain	cpdA	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS2_k127_930922_2	234267.Acid_6369	5.301e-222	697.0	COG3033@1|root,COG3033@2|Bacteria,3Y3QK@57723|Acidobacteria	57723|Acidobacteria	E	Beta-eliminating lyase	-	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_930922_14	710686.Mycsm_06161	1.709e-44	176.0	COG0451@1|root,COG0451@2|Bacteria,2I2SW@201174|Actinobacteria,23FFJ@1762|Mycobacteriaceae	201174|Actinobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_930922_16	215803.DB30_2118	7.959e-19	95.0	COG1595@1|root,COG1595@2|Bacteria,1MXVA@1224|Proteobacteria,42ZUS@68525|delta/epsilon subdivisions,2WVEB@28221|Deltaproteobacteria,2YZB9@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_930922_15	1211114.ALIP01000052_gene33	1.284e-31	135.0	COG1595@1|root,COG1595@2|Bacteria,1MXVA@1224|Proteobacteria,1S2J2@1236|Gammaproteobacteria,1X5VZ@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_930922_12	357808.RoseRS_3478	2.828e-51	193.0	COG2267@1|root,COG2267@2|Bacteria,2GBMR@200795|Chloroflexi	200795|Chloroflexi	I	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_930922_5	234267.Acid_2976	7.786e-110	366.0	COG0667@1|root,COG0667@2|Bacteria,3Y3TE@57723|Acidobacteria	57723|Acidobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_930922_10	234267.Acid_7300	1.152e-59	211.0	COG0432@1|root,COG0432@2|Bacteria,3Y4YD@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TLS2_k127_930922_1	1267535.KB906767_gene2550	7.247e-320	995.0	COG0449@1|root,COG0449@2|Bacteria,3Y2NE@57723|Acidobacteria,2JI69@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
TLS2_k127_930922_4	278957.ABEA03000126_gene3727	1.181e-136	450.0	COG3669@1|root,COG3669@2|Bacteria,46X2G@74201|Verrucomicrobia,3K9UQ@414999|Opitutae	414999|Opitutae	G	SMART glycoside hydrolase family 29 (alpha-L- fucosidase)	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
TLS2_k127_930922_3	1195236.CTER_0372	6.236e-175	560.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia	186801|Clostridia	G	family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
TLS2_k127_930922_6	234267.Acid_0029	1.667e-106	362.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria	2|Bacteria	L	Belongs to the helicase family. UvrD subfamily	addB	-	3.6.4.12,5.99.1.2	ko:K03169,ko:K16899	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	PDDEXK_1
TLS2_k127_935507_0	1267535.KB906767_gene3021	7.748e-112	376.0	COG4585@1|root,COG4585@2|Bacteria,3Y3UD@57723|Acidobacteria,2JKVP@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_935507_1	1267535.KB906767_gene3022	1.133e-76	263.0	COG2197@1|root,COG2197@2|Bacteria,3Y4RA@57723|Acidobacteria,2JMRJ@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_935507_2	204669.Acid345_1690	1.266e-56	201.0	COG0457@1|root,COG0457@2|Bacteria,3Y3MH@57723|Acidobacteria	57723|Acidobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS2_k127_93578_0	1340493.JNIF01000003_gene4361	6.363e-215	677.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
TLS2_k127_93578_3	234267.Acid_2976	9.332e-83	286.0	COG0667@1|root,COG0667@2|Bacteria,3Y3TE@57723|Acidobacteria	57723|Acidobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_93578_2	1500301.JQMF01000008_gene1056	4.017e-88	306.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2TRS9@28211|Alphaproteobacteria,4BBEI@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	mandelate racemase muconate lactonizing	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_93578_1	1267535.KB906767_gene1757	1.318e-135	456.0	COG1538@1|root,COG1538@2|Bacteria,3Y2R2@57723|Acidobacteria,2JIWN@204432|Acidobacteriia	204432|Acidobacteriia	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS2_k127_93578_4	289376.THEYE_A0922	4.964e-25	113.0	COG0845@1|root,COG0845@2|Bacteria,3J11U@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	-
TLS2_k127_957423_3	234267.Acid_1388	5.088e-21	97.0	COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	dppX	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
TLS2_k127_957423_0	471854.Dfer_0342	1.238e-111	373.0	COG2333@1|root,COG2333@2|Bacteria,4NH12@976|Bacteroidetes,47NEU@768503|Cytophagia	976|Bacteroidetes	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_957423_1	234267.Acid_6082	1.606e-59	209.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	rapK	GO:0003674,GO:0003824,GO:0016787,GO:0016801,GO:0016803	3.3.2.13,4.1.3.40,4.1.3.45	ko:K18239,ko:K18240	ko00130,ko00400,ko01100,ko01110,map00130,map00400,map01100,map01110	M00117	R01302,R10583,R10597	RC00350,RC00491,RC02148,RC03212	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribonuc_L-PSP
TLS2_k127_957423_4	459495.SPLC1_S082950	0.0009013	48.0	COG1724@1|root,COG1724@2|Bacteria,1G9XY@1117|Cyanobacteria,1HGG1@1150|Oscillatoriales	1117|Cyanobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
TLS2_k127_957423_2	378806.STAUR_7977	1.677e-47	176.0	COG4637@1|root,COG4637@2|Bacteria,1PFJA@1224|Proteobacteria,4325S@68525|delta/epsilon subdivisions,2WX6S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_958537_6	1040989.AWZU01000040_gene5983	2.196e-59	209.0	COG3193@1|root,COG3193@2|Bacteria,1RB2H@1224|Proteobacteria,2U7XA@28211|Alphaproteobacteria,3K67S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
TLS2_k127_958537_8	1145276.T479_01825	3.572e-35	148.0	COG2032@1|root,COG2032@2|Bacteria,1V3HM@1239|Firmicutes,4HHM6@91061|Bacilli,3J04V@400634|Lysinibacillus	91061|Bacilli	P	Superoxide dismutase	sodC	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
TLS2_k127_958537_9	1026882.MAMP_01710	1.297e-34	147.0	COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,1RQZK@1236|Gammaproteobacteria,460F7@72273|Thiotrichales	72273|Thiotrichales	S	PQQ-dependent catabolism-associated beta-propeller protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
TLS2_k127_958537_2	1267535.KB906767_gene4135	3.057e-133	437.0	COG3336@1|root,COG3474@1|root,COG3336@2|Bacteria,COG3474@2|Bacteria,3Y6N7@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	-	-	-	-	-	-	-	-	-	Caa3_CtaG
TLS2_k127_958537_5	265072.Mfla_1447	3.841e-66	231.0	COG1845@1|root,COG1845@2|Bacteria,1RG95@1224|Proteobacteria,2VS0Y@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c oxidase subunit III	-	-	-	-	-	-	-	-	-	-	-	-	COX3
TLS2_k127_958537_1	1123229.AUBC01000012_gene2722	6.516e-267	835.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,3JRC2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS2_k127_958537_4	265072.Mfla_1449	1.041e-94	320.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VQ5E@28216|Betaproteobacteria,2KP6C@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Cytochrome C oxidase subunit II, periplasmic domain	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,Cytochrom_C
TLS2_k127_958537_7	234267.Acid_6910	5.269e-41	157.0	COG2010@1|root,COG2010@2|Bacteria,3Y7WV@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3
TLS2_k127_958537_3	765698.Mesci_6201	2.82e-96	323.0	COG0834@1|root,COG0834@2|Bacteria,1MWWZ@1224|Proteobacteria,2TU2F@28211|Alphaproteobacteria,43JJK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	ET	PFAM extracellular solute-binding protein, family 3	-	-	-	ko:K16254	ko00680,ko01120,map00680,map01120	-	-	-	ko00000,ko00001	-	-	-	SBP_bac_3
TLS2_k127_958537_0	265072.Mfla_1451	1.428e-278	870.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria,2KKUA@206350|Nitrosomonadales	206350|Nitrosomonadales	G	TIGRFAM PQQ-dependent dehydrogenase, methanol ethanol family	-	-	-	-	-	-	-	-	-	-	-	-	PQQ
TLS2_k127_958537_10	1267535.KB906767_gene1211	4.725e-19	93.0	2ANB8@1|root,31D9I@2|Bacteria,3Y8WC@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_965741_0	290397.Adeh_1023	1.907e-155	496.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,42M0Z@68525|delta/epsilon subdivisions,2WK36@28221|Deltaproteobacteria,2Z0TJ@29|Myxococcales	28221|Deltaproteobacteria	P	arsenical-resistance protein	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
TLS2_k127_965741_3	1254432.SCE1572_04635	2.95e-40	151.0	COG0640@1|root,COG0640@2|Bacteria,1N7I7@1224|Proteobacteria,42VTU@68525|delta/epsilon subdivisions,2WRGJ@28221|Deltaproteobacteria,2YVHK@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
TLS2_k127_965741_1	395019.Bmul_5668	3.978e-117	387.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,2VK65@28216|Betaproteobacteria,1K4KH@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Arsenite-activated ATPase (ArsA)	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase,CbiA
TLS2_k127_965741_2	1367847.JCM7686_3123	9.834e-42	154.0	COG1082@1|root,COG1082@2|Bacteria,1MVSJ@1224|Proteobacteria,2TV5J@28211|Alphaproteobacteria,2PUJD@265|Paracoccus	28211|Alphaproteobacteria	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS2_k127_98460_1	234267.Acid_0512	1.727e-62	216.0	COG0823@1|root,COG0823@2|Bacteria,3Y2RC@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
TLS2_k127_98460_0	234267.Acid_0513	4.522e-90	304.0	COG2885@1|root,COG2885@2|Bacteria,3Y3ZY@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
TLS2_k127_98460_2	234267.Acid_0514	1.761e-50	190.0	COG1729@1|root,COG1729@2|Bacteria,3Y3H6@57723|Acidobacteria	57723|Acidobacteria	S	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
TLS2_k127_98460_3	247633.GP2143_13056	0.0007058	43.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_988651_1	234267.Acid_4795	4.005e-37	149.0	COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_988651_0	1382356.JQMP01000004_gene486	1.527e-240	754.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia	189775|Thermomicrobia	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
TLS2_k127_997119_1	344747.PM8797T_11434	1.299e-24	108.0	COG3436@1|root,COG3436@2|Bacteria,2J11P@203682|Planctomycetes	203682|Planctomycetes	L	PFAM IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
TLS2_k127_997119_0	314230.DSM3645_28397	1.033e-149	481.0	COG5433@1|root,COG5433@2|Bacteria,2IWUI@203682|Planctomycetes	203682|Planctomycetes	L	COG5433 Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
TLS2_k127_997119_3	448385.sce1833	0.000108	48.0	COG1662@1|root,COG1662@2|Bacteria,1MV8R@1224|Proteobacteria	1224|Proteobacteria	L	PFAM IS1 transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1
## 6502 queries scanned
## Total time (seconds): 114.52985548973083
## Rate: 56.77 q/s