## Sat Nov 16 03:55:10 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin27/TLS_2_bin.16.fa -m mmseqs --itype genome -o TLS_2_bin.16 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/TLS_2_bin.16 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TLS2_k127_1014560_0	401053.AciPR4_1773	0.0	1344.0	COG0178@1|root,COG0178@2|Bacteria,3Y3G9@57723|Acidobacteria,2JI80@204432|Acidobacteriia	204432|Acidobacteriia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_1014560_33	240015.ACP_2898	2.465e-11	74.0	2CUDA@1|root,32SV3@2|Bacteria,3Y5SK@57723|Acidobacteria,2JJYC@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1014560_18	204669.Acid345_0778	7.814e-80	279.0	2CADG@1|root,2Z8QW@2|Bacteria,3Y35X@57723|Acidobacteria,2JHZ3@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1014560_23	1267533.KB906734_gene3988	7.815e-49	194.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,3Y3F8@57723|Acidobacteria,2JKAW@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
TLS2_k127_1014560_30	1267535.KB906767_gene2422	6.688e-21	108.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,GSDH,HYR,He_PIG,Laminin_G_3,Malectin,NPCBM
TLS2_k127_1014560_31	1158292.JPOE01000005_gene904	2.946e-16	93.0	COG2706@1|root,COG3391@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,1RB38@1224|Proteobacteria,2VSAM@28216|Betaproteobacteria,1KNMC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS2_k127_1014560_5	204669.Acid345_0779	1.881e-228	724.0	COG1793@1|root,COG1793@2|Bacteria,3Y2VV@57723|Acidobacteria,2JIJ7@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA ligase D, 3'-phosphoesterase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS2_k127_1014560_22	1297742.A176_02519	4.971e-61	236.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_1014560_4	204669.Acid345_1344	8.97e-255	810.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,3Y8VM@57723|Acidobacteria	2|Bacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
TLS2_k127_1014560_12	204669.Acid345_1345	6.257e-143	512.0	COG1361@1|root,COG1572@1|root,COG3712@1|root,COG1361@2|Bacteria,COG1572@2|Bacteria,COG3712@2|Bacteria	2|Bacteria	PT	iron ion homeostasis	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	DUF11,FecR
TLS2_k127_1014560_24	204669.Acid345_1350	1.609e-47	174.0	COG1051@1|root,COG1051@2|Bacteria,3Y5BM@57723|Acidobacteria,2JJTC@204432|Acidobacteriia	204432|Acidobacteriia	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_1014560_17	204669.Acid345_1349	4.895e-83	280.0	COG0163@1|root,COG0163@2|Bacteria,3Y2S8@57723|Acidobacteria,2JI3S@204432|Acidobacteriia	204432|Acidobacteriia	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
TLS2_k127_1014560_8	204669.Acid345_1348	5.286e-173	559.0	COG3016@1|root,COG3016@2|Bacteria	2|Bacteria	S	Haem-binding uptake, Tiki superfamily, ChaN	phuW	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
TLS2_k127_1014560_21	234267.Acid_1248	2.209e-71	250.0	COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,3Y3N9@57723|Acidobacteria	57723|Acidobacteria	P	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,SNARE_assoc
TLS2_k127_1014560_34	1267535.KB906767_gene561	3.861e-11	64.0	COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,3Y3N9@57723|Acidobacteria,2JHWT@204432|Acidobacteriia	204432|Acidobacteriia	P	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,SNARE_assoc
TLS2_k127_1014560_19	497964.CfE428DRAFT_4347	7.436e-79	266.0	COG2514@1|root,COG2514@2|Bacteria,46SQP@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
TLS2_k127_1014560_6	1267533.KB906736_gene1115	3.999e-198	627.0	COG0015@1|root,COG0015@2|Bacteria,3Y2QW@57723|Acidobacteria,2JIAC@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
TLS2_k127_1014560_15	1294143.H681_07975	1.45e-97	334.0	COG3386@1|root,COG3386@2|Bacteria,1MX7V@1224|Proteobacteria,1RMQK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	gluconolactonase	-	-	-	-	-	-	-	-	-	-	-	-	Str_synth
TLS2_k127_1014560_27	237368.SCABRO_01429	7.782e-36	149.0	COG0265@1|root,COG1716@1|root,COG0265@2|Bacteria,COG1716@2|Bacteria,2J23K@203682|Planctomycetes	203682|Planctomycetes	OT	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Trypsin_2
TLS2_k127_1014560_32	861299.J421_2424	4.926e-15	86.0	2E0D8@1|root,32W02@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1014560_37	234267.Acid_7925	1.359e-05	48.0	COG3832@1|root,COG3832@2|Bacteria,3Y94H@57723|Acidobacteria	57723|Acidobacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1014560_1	1340493.JNIF01000003_gene1805	0.0	1328.0	COG0542@1|root,COG0542@2|Bacteria,3Y35D@57723|Acidobacteria	57723|Acidobacteria	O	Belongs to the ClpA ClpB family	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS2_k127_1014560_14	204669.Acid345_3572	2.301e-98	326.0	COG1136@1|root,COG1136@2|Bacteria,3Y412@57723|Acidobacteria,2JIJG@204432|Acidobacteriia	204432|Acidobacteriia	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
TLS2_k127_1014560_20	1380394.JADL01000005_gene5400	1.116e-76	261.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2TUP5@28211|Alphaproteobacteria,2JQMB@204441|Rhodospirillales	204441|Rhodospirillales	L	COG2818 3-methyladenine DNA glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
TLS2_k127_1014560_9	204669.Acid345_3567	7.808e-165	528.0	COG4591@1|root,COG4591@2|Bacteria,3Y3BU@57723|Acidobacteria,2JIC6@204432|Acidobacteriia	204432|Acidobacteriia	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
TLS2_k127_1014560_25	204669.Acid345_3566	6.442e-38	150.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	2.1.1.100	ko:K00587	ko00900,ko01130,map00900,map01130	-	R04496	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	ICMT,PEMT
TLS2_k127_1014560_2	204669.Acid345_3565	9.523e-261	826.0	COG3209@1|root,COG3209@2|Bacteria,3Y996@57723|Acidobacteria	57723|Acidobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1014560_3	204669.Acid345_3562	1.544e-259	813.0	COG1044@1|root,COG1044@2|Bacteria,3Y2ZS@57723|Acidobacteria,2JIC3@204432|Acidobacteriia	204432|Acidobacteriia	M	SpoIVB peptidase S55	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S55
TLS2_k127_1014560_13	204669.Acid345_3561	2.074e-122	407.0	COG2304@1|root,COG2304@2|Bacteria,3Y3QQ@57723|Acidobacteria,2JHV1@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
TLS2_k127_1014560_16	204669.Acid345_3196	6.766e-90	302.0	COG0428@1|root,COG0428@2|Bacteria,3Y4A7@57723|Acidobacteria,2JJ1K@204432|Acidobacteriia	204432|Acidobacteriia	P	ZIP Zinc transporter	-	-	-	ko:K07238,ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11,2.A.5.5	-	-	Zip
TLS2_k127_1014560_29	880072.Desac_2180	2.982e-33	139.0	COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,42W70@68525|delta/epsilon subdivisions,2WRUT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
TLS2_k127_1014560_10	204669.Acid345_3198	1.211e-163	523.0	COG0012@1|root,COG0012@2|Bacteria,3Y3D9@57723|Acidobacteria,2JIPE@204432|Acidobacteriia	204432|Acidobacteriia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
TLS2_k127_1014560_28	204669.Acid345_3199	9.812e-36	141.0	2ED8Q@1|root,33759@2|Bacteria,3Y5NT@57723|Acidobacteria,2JJWR@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4149)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4149
TLS2_k127_1014560_11	204669.Acid345_3201	7.544e-151	487.0	COG0714@1|root,COG0714@2|Bacteria,3Y4G8@57723|Acidobacteria,2JKTE@204432|Acidobacteriia	204432|Acidobacteriia	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_1014560_36	706587.Desti_4145	9.374e-10	59.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,2MQ6Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS2_k127_1017372_4	204669.Acid345_1287	7.966e-44	164.0	COG0838@1|root,COG0838@2|Bacteria,3Y59B@57723|Acidobacteria,2JNDX@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TLS2_k127_1017372_2	204669.Acid345_3211	1.045e-193	627.0	COG1228@1|root,COG1228@2|Bacteria,3Y32S@57723|Acidobacteria,2JIA1@204432|Acidobacteriia	2|Bacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_1017372_0	204669.Acid345_1286	1.985e-229	720.0	COG1190@1|root,COG1190@2|Bacteria,3Y3N0@57723|Acidobacteria,2JI1W@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
TLS2_k127_1017372_3	1380394.JADL01000002_gene1538	2.323e-113	375.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2TQRX@28211|Alphaproteobacteria,2JPEG@204441|Rhodospirillales	204441|Rhodospirillales	FL	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
TLS2_k127_1017372_1	204669.Acid345_1282	3.649e-196	623.0	COG0076@1|root,COG0076@2|Bacteria,3Y3S7@57723|Acidobacteria,2JJ5R@204432|Acidobacteriia	57723|Acidobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
TLS2_k127_1017372_5	1267535.KB906767_gene9	2.189e-17	91.0	COG0810@1|root,COG0810@2|Bacteria,3Y4BU@57723|Acidobacteria,2JJ3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
TLS2_k127_1019537_71	1298593.TOL_1516	3.357e-33	132.0	COG0589@1|root,COG0589@2|Bacteria,1QCT3@1224|Proteobacteria,1SI82@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_1019537_64	204669.Acid345_4162	1.021e-39	152.0	COG1438@1|root,COG1438@2|Bacteria,3Y551@57723|Acidobacteria,2JJTA@204432|Acidobacteriia	204432|Acidobacteriia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
TLS2_k127_1019537_21	204669.Acid345_4161	1.376e-128	420.0	COG0002@1|root,COG0002@2|Bacteria,3Y450@57723|Acidobacteria,2JHSX@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_1019537_39	240015.ACP_2994	9.679e-89	310.0	COG0548@1|root,COG0548@2|Bacteria,3Y2IF@57723|Acidobacteria,2JIE8@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
TLS2_k127_1019537_31	1382359.JIAL01000001_gene2594	4.346e-107	370.0	COG0078@1|root,COG0078@2|Bacteria,3Y3WW@57723|Acidobacteria,2JHPN@204432|Acidobacteriia	204432|Acidobacteriia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_1019537_8	204669.Acid345_4158	4.603e-199	627.0	COG0137@1|root,COG0137@2|Bacteria,3Y4Y9@57723|Acidobacteria,2JJKA@204432|Acidobacteriia	204432|Acidobacteriia	E	Arginosuccinate synthase	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
TLS2_k127_1019537_13	204669.Acid345_4157	2.837e-161	522.0	COG0165@1|root,COG0165@2|Bacteria,3Y36Y@57723|Acidobacteria,2JHU3@204432|Acidobacteriia	204432|Acidobacteriia	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
TLS2_k127_1019537_60	639030.JHVA01000001_gene60	1.142e-49	186.0	COG1246@1|root,COG1246@2|Bacteria,3Y3WV@57723|Acidobacteria,2JISF@204432|Acidobacteriia	204432|Acidobacteriia	E	Acetyltransferase (GNAT) family	-	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
TLS2_k127_1019537_72	216142.LT40_05770	7.374e-31	135.0	COG0517@1|root,COG2199@1|root,COG2200@1|root,COG0517@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,1RRCA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF
TLS2_k127_1019537_82	1297742.A176_00264	4.463e-14	76.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2Z2X4@29|Myxococcales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	FHA,HTH_8,Response_reg,Sigma54_activat
TLS2_k127_1019537_11	204669.Acid345_3017	8.453e-174	556.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria,2JICQ@204432|Acidobacteriia	57723|Acidobacteria	T	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_1019537_44	1144275.COCOR_03677	1.496e-80	306.0	COG2202@1|root,COG3852@1|root,COG2202@2|Bacteria,COG3852@2|Bacteria,1NWNJ@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,SBP_bac_3
TLS2_k127_1019537_62	1210884.HG799466_gene12816	2.752e-46	194.0	COG2203@1|root,COG3852@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3852@2|Bacteria,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_1019537_68	204669.Acid345_1365	5.796e-36	149.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	2.7.7.65	ko:K13590	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF,dCache_1
TLS2_k127_1019537_23	1449126.JQKL01000014_gene2969	3.399e-118	395.0	COG2031@1|root,COG2031@2|Bacteria,1TPCQ@1239|Firmicutes,247SN@186801|Clostridia,2680H@186813|unclassified Clostridiales	186801|Clostridia	I	Short chain fatty acid transporter	-	-	-	ko:K02106	ko02020,map02020	-	-	-	ko00000,ko00001	2.A.73.1	-	-	SCFA_trans
TLS2_k127_1019537_37	66377.JOBH01000014_gene4575	3.298e-90	327.0	COG1352@1|root,COG1352@2|Bacteria,2HHZ1@201174|Actinobacteria	201174|Actinobacteria	NT	PFAM MCP methyltransferase, CheR-type	cheR	-	2.1.1.80,3.1.1.61	ko:K00575,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheR,CheR_N,PAS,PAS_4,PAS_9
TLS2_k127_1019537_61	1156844.KB891804_gene2242	8.169e-49	189.0	COG2201@1|root,COG2201@2|Bacteria,2GMBC@201174|Actinobacteria	201174|Actinobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest
TLS2_k127_1019537_79	639030.JHVA01000001_gene266	2.478e-23	106.0	COG0784@1|root,COG0784@2|Bacteria,3Y5QS@57723|Acidobacteria,2JJWS@204432|Acidobacteriia	204432|Acidobacteriia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_1019537_58	1267533.KB906734_gene3988	5.902e-58	218.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,3Y3F8@57723|Acidobacteria,2JKAW@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
TLS2_k127_1019537_76	204669.Acid345_2462	2.415e-26	123.0	COG0784@1|root,COG0784@2|Bacteria,3Y5K0@57723|Acidobacteria,2JJYE@204432|Acidobacteriia	204432|Acidobacteriia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_1019537_35	1122179.KB890458_gene744	2.029e-91	323.0	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1IPY5@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_1019537_46	926556.Echvi_1781	6.879e-75	271.0	COG0612@1|root,COG0612@2|Bacteria,4NEPT@976|Bacteroidetes,47M2G@768503|Cytophagia	976|Bacteroidetes	S	Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_1019537_0	1382359.JIAL01000001_gene844	0.0	1120.0	COG0567@1|root,COG0567@2|Bacteria,3Y3EF@57723|Acidobacteria,2JICX@204432|Acidobacteriia	204432|Acidobacteriia	C	2-oxoglutarate dehydrogenase, E1	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,OxoGdeHyase_C,Transket_pyr
TLS2_k127_1019537_10	1382359.JIAL01000001_gene1014	1.088e-188	611.0	COG0038@1|root,COG0038@2|Bacteria,3Y2G4@57723|Acidobacteria,2JIJC@204432|Acidobacteriia	204432|Acidobacteriia	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	Voltage_CLC
TLS2_k127_1019537_67	1267533.KB906735_gene4555	3.163e-36	152.0	COG0457@1|root,COG0457@2|Bacteria,3Y7BQ@57723|Acidobacteria,2JMD5@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
TLS2_k127_1019537_53	204669.Acid345_2077	1.312e-67	232.0	COG0432@1|root,COG0432@2|Bacteria,3Y4R6@57723|Acidobacteria,2JJ9H@204432|Acidobacteriia	204432|Acidobacteriia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TLS2_k127_1019537_2	1382359.JIAL01000001_gene136	1.935e-301	944.0	COG1674@1|root,COG1674@2|Bacteria,3Y3CJ@57723|Acidobacteria,2JHRN@204432|Acidobacteriia	204432|Acidobacteriia	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TLS2_k127_1019537_50	234267.Acid_5064	3.758e-70	246.0	COG1968@1|root,COG1968@2|Bacteria,3Y588@57723|Acidobacteria	57723|Acidobacteria	V	Bacitracin resistance protein BacA	-	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
TLS2_k127_1019537_41	204669.Acid345_2083	3.068e-85	293.0	COG1729@1|root,COG1729@2|Bacteria,3Y4ET@57723|Acidobacteria,2JJ38@204432|Acidobacteriia	204432|Acidobacteriia	S	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1019537_51	404589.Anae109_1343	7.308e-70	259.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria,2YXKT@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_1019537_52	1502852.FG94_02765	3.387e-68	251.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria,476TQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_1019537_25	1382359.JIAL01000001_gene561	7.167e-115	379.0	COG1171@1|root,COG1171@2|Bacteria,3Y2UN@57723|Acidobacteria,2JI1Z@204432|Acidobacteriia	204432|Acidobacteriia	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_1019537_3	204669.Acid345_2092	1.124e-287	898.0	COG0595@1|root,COG0595@2|Bacteria,3Y2NH@57723|Acidobacteria,2JI53@204432|Acidobacteriia	204432|Acidobacteriia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
TLS2_k127_1019537_34	1384054.N790_04135	7.35e-103	351.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1X37F@135614|Xanthomonadales	135614|Xanthomonadales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	gltP	-	-	ko:K03309	-	-	-	-	ko00000	2.A.23	-	-	SDF
TLS2_k127_1019537_24	204669.Acid345_2087	9.705e-118	385.0	COG2171@1|root,COG2171@2|Bacteria,3Y2Z3@57723|Acidobacteria,2JIDV@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the transferase hexapeptide repeat family	-	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep_2,THDPS_N_2
TLS2_k127_1019537_20	204669.Acid345_2493	1.628e-133	436.0	COG0329@1|root,COG0329@2|Bacteria,3Y3V8@57723|Acidobacteria,2JICI@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_1019537_47	204669.Acid345_2492	2.661e-74	259.0	COG0289@1|root,COG0289@2|Bacteria,3Y50R@57723|Acidobacteria,2JJFV@204432|Acidobacteriia	204432|Acidobacteriia	E	Dihydrodipicolinate reductase, C-terminus	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
TLS2_k127_1019537_9	204669.Acid345_2491	4.14e-193	612.0	COG0527@1|root,COG0527@2|Bacteria,3Y34W@57723|Acidobacteria,2JHV2@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT
TLS2_k127_1019537_14	204669.Acid345_2490	8.975e-153	489.0	COG0136@1|root,COG0136@2|Bacteria,3Y346@57723|Acidobacteria,2JHXJ@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the aspartate-semialdehyde dehydrogenase family	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_1019537_33	118173.KB235914_gene497	1.081e-106	355.0	COG1085@1|root,COG1085@2|Bacteria,1G1CA@1117|Cyanobacteria,1H82Z@1150|Oscillatoriales	1117|Cyanobacteria	C	galactose-1-phosphate	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf,HIT
TLS2_k127_1019537_74	204669.Acid345_2488	1.101e-27	120.0	COG0703@1|root,COG0703@2|Bacteria,3Y4R0@57723|Acidobacteria,2JJAZ@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
TLS2_k127_1019537_84	283942.IL1934	0.000672	51.0	COG3595@1|root,COG3595@2|Bacteria,1P19T@1224|Proteobacteria,1RRSR@1236|Gammaproteobacteria,2QG24@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_1019537_28	204669.Acid345_2486	1.028e-111	362.0	COG1595@1|root,COG1595@2|Bacteria,3Y3HD@57723|Acidobacteria,2JHY0@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_1019537_12	935863.AWZR01000001_gene2060	4.369e-172	554.0	COG0477@1|root,COG2814@2|Bacteria,1R5AK@1224|Proteobacteria	1224|Proteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_1019537_16	204669.Acid345_2477	2.237e-146	471.0	COG0476@1|root,COG0476@2|Bacteria,3Y2HZ@57723|Acidobacteria,2JHXP@204432|Acidobacteriia	204432|Acidobacteriia	H	MoeZ MoeB	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
TLS2_k127_1019537_4	204669.Acid345_2476	1.422e-273	875.0	COG0729@1|root,COG4775@1|root,COG0729@2|Bacteria,COG4775@2|Bacteria,3Y2RF@57723|Acidobacteria,2JHK5@204432|Acidobacteriia	204432|Acidobacteriia	M	surface antigen variable number	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
TLS2_k127_1019537_66	204669.Acid345_2475	1.081e-36	150.0	COG0760@1|root,COG0760@2|Bacteria,3Y4KY@57723|Acidobacteria,2JJDJ@204432|Acidobacteriia	204432|Acidobacteriia	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	-	-	-	-	-	-	-	-	-	-	-	-	SurA_N_3
TLS2_k127_1019537_1	204669.Acid345_2474	0.0	1047.0	COG2911@1|root,COG2911@2|Bacteria,3Y3A6@57723|Acidobacteria,2JHS8@204432|Acidobacteriia	204432|Acidobacteriia	M	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
TLS2_k127_1019537_56	204669.Acid345_2473	8.291e-63	238.0	COG2518@1|root,COG2518@2|Bacteria	2|Bacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
TLS2_k127_1019537_32	1267534.KB906754_gene3066	6.016e-107	367.0	COG0382@1|root,COG0382@2|Bacteria,3Y3CW@57723|Acidobacteria,2JIHD@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM UbiA prenyltransferase	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TLS2_k127_1019537_78	234267.Acid_7238	2.005e-25	109.0	COG1278@1|root,COG1278@2|Bacteria,3Y5GC@57723|Acidobacteria	57723|Acidobacteria	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_1019537_7	1382359.JIAL01000001_gene603	5.884e-201	631.0	COG1060@1|root,COG1060@2|Bacteria,3Y331@57723|Acidobacteria,2JKW7@204432|Acidobacteriia	204432|Acidobacteriia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1019537_38	204669.Acid345_0600	3.949e-90	310.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Ribosomal_S30AE,Sigma70_r2,Sigma70_r4_2
TLS2_k127_1019537_30	204669.Acid345_0601	3.209e-109	366.0	COG1503@1|root,COG1503@2|Bacteria,3Y8BP@57723|Acidobacteria,2JN5Y@204432|Acidobacteriia	204432|Acidobacteriia	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1019537_19	204669.Acid345_0602	3.927e-136	446.0	COG1446@1|root,COG1446@2|Bacteria,3Y2Y8@57723|Acidobacteria,2JIW3@204432|Acidobacteriia	204432|Acidobacteriia	E	Asparaginase	-	-	3.5.1.26	ko:K01444	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Asparaginase_2
TLS2_k127_1019537_70	1297742.A176_07321	3.298e-33	141.0	COG4219@1|root,COG4219@2|Bacteria,1P0K4@1224|Proteobacteria	1224|Proteobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1019537_18	1267535.KB906767_gene3449	5.131e-138	450.0	COG1494@1|root,COG1494@2|Bacteria,3Y2XJ@57723|Acidobacteria,2JKWZ@204432|Acidobacteriia	204432|Acidobacteriia	G	Bacterial fructose-1,6-bisphosphatase, glpX-encoded	-	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
TLS2_k127_1019537_6	204669.Acid345_0610	1.605e-217	679.0	COG1960@1|root,COG1960@2|Bacteria,3Y2FM@57723|Acidobacteria,2JIVG@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_1019537_75	1267533.KB906736_gene890	2.303e-26	109.0	2EADF@1|root,334H8@2|Bacteria,3Y5JG@57723|Acidobacteria,2JJZH@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1019537_48	204669.Acid345_2594	8.499e-74	256.0	COG0284@1|root,COG0284@2|Bacteria,3Y2XD@57723|Acidobacteria,2JIQY@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
TLS2_k127_1019537_65	204669.Acid345_2593	2.063e-38	149.0	COG0797@1|root,COG0797@2|Bacteria,3Y5M1@57723|Acidobacteria,2JJX9@204432|Acidobacteriia	204432|Acidobacteriia	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
TLS2_k127_1019537_54	204669.Acid345_2592	1.166e-65	233.0	COG0351@1|root,COG0351@2|Bacteria,3Y4DB@57723|Acidobacteria,2JJ2D@204432|Acidobacteriia	204432|Acidobacteriia	H	Phosphomethylpyrimidine kinase	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
TLS2_k127_1019537_26	204669.Acid345_1278	2.901e-113	379.0	COG0457@1|root,COG0457@2|Bacteria,3Y76R@57723|Acidobacteria,2JMJZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Sel1-like repeats.	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1019537_57	204669.Acid345_1279	5.481e-59	215.0	2F7WV@1|root,340AU@2|Bacteria,3Y8A1@57723|Acidobacteria,2JN8N@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1019537_80	240015.ACP_0220	1.156e-18	90.0	COG1983@1|root,COG1983@2|Bacteria,3Y5HA@57723|Acidobacteria,2JJXD@204432|Acidobacteriia	204432|Acidobacteriia	KT	PspC domain	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC,zinc_ribbon_2
TLS2_k127_1019537_45	204669.Acid345_3365	2.815e-77	267.0	COG0596@1|root,COG0596@2|Bacteria,3Y4YX@57723|Acidobacteria,2JJKK@204432|Acidobacteriia	204432|Acidobacteriia	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_1019537_73	1340493.JNIF01000003_gene4692	4.871e-30	124.0	2E6AT@1|root,330YQ@2|Bacteria,3Y5M7@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1019537_63	204669.Acid345_3615	1.646e-43	182.0	COG0457@1|root,COG0457@2|Bacteria	204669.Acid345_3615|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1019537_15	204669.Acid345_3614	2.605e-151	489.0	COG0128@1|root,COG0128@2|Bacteria,3Y3RH@57723|Acidobacteria,2JI7W@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TLS2_k127_1019537_69	1267533.KB906736_gene1174	7.687e-34	137.0	2FD9D@1|root,345BB@2|Bacteria,3Y8R5@57723|Acidobacteria,2JNGY@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1019537_22	398767.Glov_3570	4.223e-121	403.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_1019537_42	443144.GM21_2025	1.074e-84	289.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P96@68525|delta/epsilon subdivisions,2WMVB@28221|Deltaproteobacteria,43TUK@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1019537_43	243231.GSU0496	7.021e-83	293.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria,43SP7@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
TLS2_k127_1019537_49	330214.NIDE3152	5.997e-71	250.0	COG0725@1|root,COG0725@2|Bacteria,3J18Z@40117|Nitrospirae	40117|Nitrospirae	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
TLS2_k127_1019537_36	330214.NIDE3149	1.107e-90	310.0	COG4149@1|root,COG4149@2|Bacteria	2|Bacteria	P	molybdate abc transporter	modB	-	-	ko:K02018,ko:K15496	ko02010,map02010	M00189,M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.5,3.A.1.8	-	-	BPD_transp_1
TLS2_k127_1019537_40	204669.Acid345_1878	1.654e-88	310.0	COG4148@1|root,COG4148@2|Bacteria,3Y98K@57723|Acidobacteria	57723|Acidobacteria	P	TOBE domain	-	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
TLS2_k127_1019537_5	1340493.JNIF01000004_gene873	3.922e-243	776.0	COG1629@1|root,COG4771@2|Bacteria,3Y36N@57723|Acidobacteria	57723|Acidobacteria	P	PFAM TonB-dependent Receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_1019537_29	682795.AciX8_2679	4.538e-111	375.0	COG0812@1|root,COG0812@2|Bacteria,3Y3AT@57723|Acidobacteria,2JIMJ@204432|Acidobacteriia	204432|Acidobacteriia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
TLS2_k127_1019537_59	1267534.KB906759_gene1665	5.074e-54	194.0	28NYH@1|root,2ZBVN@2|Bacteria,3Y4AN@57723|Acidobacteria,2JJ51@204432|Acidobacteriia	204432|Acidobacteriia	S	Disulphide isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Disulph_isomer
TLS2_k127_1019537_27	204669.Acid345_1882	3.778e-112	374.0	COG3391@1|root,COG3391@2|Bacteria,3Y3R3@57723|Acidobacteria,2JHUC@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS2_k127_1019537_17	1382359.JIAL01000001_gene383	4.269e-146	470.0	COG2876@1|root,COG2876@2|Bacteria,3Y32G@57723|Acidobacteria,2JIXH@204432|Acidobacteriia	204432|Acidobacteriia	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
TLS2_k127_1075624_7	204669.Acid345_3255	1.533e-53	201.0	COG0300@1|root,COG0300@2|Bacteria,3Y5F6@57723|Acidobacteria,2JNN8@204432|Acidobacteriia	204432|Acidobacteriia	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_1075624_8	1267535.KB906767_gene4292	3.484e-43	166.0	COG2802@1|root,COG2802@2|Bacteria,3Y7UX@57723|Acidobacteria	57723|Acidobacteria	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LON_substr_bdg
TLS2_k127_1075624_1	204669.Acid345_3256	7.819e-233	735.0	COG1239@1|root,COG1239@2|Bacteria,3Y3FM@57723|Acidobacteria,2JHY2@204432|Acidobacteriia	204432|Acidobacteriia	H	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Sigma54_activat
TLS2_k127_1075624_2	204669.Acid345_3257	2.036e-218	682.0	COG4867@1|root,COG4867@2|Bacteria,3Y2VU@57723|Acidobacteria,2JHSR@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA_2
TLS2_k127_1075624_9	204669.Acid345_3258	1.312e-32	130.0	COG3369@1|root,COG3369@2|Bacteria,3Y5KG@57723|Acidobacteria,2JJXU@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Iron sulphur-containing domain, CDGSH-type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
TLS2_k127_1075624_0	204669.Acid345_3259	0.0	1026.0	COG3408@1|root,COG3408@2|Bacteria,3Y7DE@57723|Acidobacteria,2JKY9@204432|Acidobacteriia	204432|Acidobacteriia	G	N-terminal domain of (some) glycogen debranching enzymes	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
TLS2_k127_1075624_5	204669.Acid345_3260	1.314e-135	441.0	COG0438@1|root,COG0438@2|Bacteria,3Y6NY@57723|Acidobacteria,2JMG8@204432|Acidobacteriia	204432|Acidobacteriia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_1075624_3	204669.Acid345_3263	1.196e-152	493.0	COG4641@1|root,COG4641@2|Bacteria,3Y2UP@57723|Acidobacteria,2JKI0@204432|Acidobacteriia	204432|Acidobacteriia	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
TLS2_k127_1075624_4	204669.Acid345_3264	3.434e-136	443.0	COG0438@1|root,COG0438@2|Bacteria,3Y4P9@57723|Acidobacteria,2JN0H@204432|Acidobacteriia	204432|Acidobacteriia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4
TLS2_k127_1075624_11	406124.ACPC01000019_gene2810	7.165e-10	60.0	2EFZF@1|root,339RM@2|Bacteria,1VMG6@1239|Firmicutes,4HR8G@91061|Bacilli,1ZK3J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1075624_10	1382359.JIAL01000001_gene2488	2.298e-26	114.0	2E82Q@1|root,332GQ@2|Bacteria,3Y5JA@57723|Acidobacteria,2JK1I@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1075624_6	204669.Acid345_3269	2.962e-66	229.0	COG2204@1|root,COG2204@2|Bacteria,3Y3HZ@57723|Acidobacteria,2JI47@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_1078332_1	477974.Daud_0851	0.0	1467.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,264Z9@186807|Peptococcaceae	186801|Clostridia	G	Alpha-amylase domain	ams	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
TLS2_k127_1078332_0	204669.Acid345_1124	0.0	1529.0	COG0209@1|root,COG0209@2|Bacteria,3Y3Q1@57723|Acidobacteria,2JITI@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
TLS2_k127_1078332_2	1267533.KB906734_gene3815	6.704e-06	49.0	COG0209@1|root,COG0209@2|Bacteria,3Y3Q1@57723|Acidobacteria,2JITI@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
TLS2_k127_1088930_0	204669.Acid345_0008	2.515e-302	941.0	COG0187@1|root,COG0187@2|Bacteria,3Y369@57723|Acidobacteria,2JI1D@204432|Acidobacteriia	204432|Acidobacteriia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS2_k127_1088930_1	1123368.AUIS01000023_gene925	1.313e-74	260.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	antiporter	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
TLS2_k127_1119712_2	204669.Acid345_4761	1.024e-28	117.0	COG0312@1|root,COG0312@2|Bacteria,3Y2TY@57723|Acidobacteria,2JI8B@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS2_k127_1119712_0	204669.Acid345_4762	1.328e-177	572.0	28N30@1|root,2ZB8S@2|Bacteria,3Y2XH@57723|Acidobacteria,2JI3V@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1119712_1	204669.Acid345_0057	9.519e-31	126.0	COG0322@1|root,COG0322@2|Bacteria,3Y3HU@57723|Acidobacteria,2JHSF@204432|Acidobacteriia	204432|Acidobacteriia	L	excinuclease ABC activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1132995_1	204669.Acid345_1751	2.031e-203	640.0	COG1109@1|root,COG1109@2|Bacteria,3Y2Y6@57723|Acidobacteria,2JHZU@204432|Acidobacteriia	204432|Acidobacteriia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_1132995_11	682795.AciX8_2958	2.747e-20	98.0	COG2919@1|root,COG2919@2|Bacteria,3Y8Q1@57723|Acidobacteria,2JNDU@204432|Acidobacteriia	204432|Acidobacteriia	D	Septum formation initiator	-	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
TLS2_k127_1132995_12	204669.Acid345_1753	1.821e-08	61.0	2EQAC@1|root,33HWH@2|Bacteria,3Y5W6@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1132995_8	489825.LYNGBM3L_40900	1.826e-50	186.0	COG0431@1|root,COG0431@2|Bacteria,1G3AZ@1117|Cyanobacteria,1HAU3@1150|Oscillatoriales	1117|Cyanobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS2_k127_1132995_0	1267534.KB906759_gene1947	2.138e-277	874.0	COG1529@1|root,COG1529@2|Bacteria,3Y6BF@57723|Acidobacteria	57723|Acidobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_1132995_7	1267534.KB906759_gene1948	6.734e-58	205.0	COG2080@1|root,COG2080@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	coxS	-	1.2.5.3,1.3.99.16	ko:K03518,ko:K07302	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_1132995_6	926566.Terro_0848	7.388e-74	259.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	-	-	1.17.1.4	ko:K13479	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_1132995_3	448385.sce5876	1.122e-169	546.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,42RF2@68525|delta/epsilon subdivisions,2WP05@28221|Deltaproteobacteria,2YWCM@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	allB	-	3.5.2.5	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02425	RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS2_k127_1132995_2	1254432.SCE1572_35005	1.991e-172	559.0	COG3195@1|root,COG4266@1|root,COG3195@2|Bacteria,COG4266@2|Bacteria,1MXJK@1224|Proteobacteria,42YE0@68525|delta/epsilon subdivisions,2X30N@28221|Deltaproteobacteria,2YTWS@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the allantoicase family	alc	-	3.5.3.4	ko:K01477	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02422	RC00379,RC00712	ko00000,ko00001,ko00002,ko01000	-	-	-	Allantoicase,OHCU_decarbox
TLS2_k127_1132995_10	378806.STAUR_1035	1.562e-31	128.0	COG2351@1|root,COG2351@2|Bacteria,1RH84@1224|Proteobacteria,42W18@68525|delta/epsilon subdivisions,2X9WW@28221|Deltaproteobacteria,2YVN9@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily	-	-	3.5.2.17	ko:K07127	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06601	RC03393	ko00000,ko00001,ko00002,ko01000,ko02000	9.B.35.1.2,9.B.35.2	-	-	Transthyretin
TLS2_k127_1132995_5	448385.sce4023	1.787e-83	286.0	COG3648@1|root,COG3648@2|Bacteria,1PX3F@1224|Proteobacteria	1224|Proteobacteria	Q	Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin	pucL	-	1.7.3.3	ko:K00365	ko00230,ko00232,ko01100,ko01120,map00230,map00232,map01100,map01120	M00546	R02106,R07981	RC02107,RC02551	ko00000,ko00001,ko00002,ko01000	-	-	-	Uricase
TLS2_k127_1132995_4	378806.STAUR_1028	2.389e-156	506.0	COG2301@1|root,COG2301@2|Bacteria,1R7U2@1224|Proteobacteria,437FH@68525|delta/epsilon subdivisions,2X2N4@28221|Deltaproteobacteria,2YTXN@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
TLS2_k127_1132995_9	479434.Sthe_2331	7.519e-44	174.0	KOG2524@1|root,2ZJ84@2|Bacteria,2G826@200795|Chloroflexi,27XIS@189775|Thermomicrobia	189775|Thermomicrobia	S	Potential Queuosine, Q, salvage protein family	-	-	-	-	-	-	-	-	-	-	-	-	Q_salvage
TLS2_k127_1134093_0	204669.Acid345_0041	1.725e-111	366.0	COG1192@1|root,COG1192@2|Bacteria,3Y2Y2@57723|Acidobacteria,2JI26@204432|Acidobacteriia	204432|Acidobacteriia	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS2_k127_1134093_1	861299.J421_4343	1.055e-62	221.0	COG0262@1|root,COG0262@2|Bacteria,1ZU5U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_1134093_2	861299.J421_4344	2.548e-60	215.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
TLS2_k127_1137017_0	204669.Acid345_3781	1.871e-244	767.0	COG1132@1|root,COG1132@2|Bacteria,3Y2Y9@57723|Acidobacteria,2JI79@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
TLS2_k127_1137017_2	204669.Acid345_3780	1.502e-107	355.0	COG1561@1|root,COG1561@2|Bacteria,3Y2HQ@57723|Acidobacteria,2JIXS@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
TLS2_k127_1137017_3	204669.Acid345_3778	1.027e-71	252.0	COG0194@1|root,COG0194@2|Bacteria,3Y2JW@57723|Acidobacteria,2JJ0I@204432|Acidobacteriia	204432|Acidobacteriia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
TLS2_k127_1137017_4	204669.Acid345_3777	5.235e-20	92.0	COG1758@1|root,COG1758@2|Bacteria,3Y5Z6@57723|Acidobacteria,2JK65@204432|Acidobacteriia	204432|Acidobacteriia	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	-	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
TLS2_k127_1137017_1	204669.Acid345_3776	4.084e-140	452.0	COG0452@1|root,COG0452@2|Bacteria,3Y2QJ@57723|Acidobacteria,2JIK5@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TLS2_k127_1140382_1	1382359.JIAL01000001_gene723	5.812e-248	772.0	COG1012@1|root,COG1012@2|Bacteria,3Y37W@57723|Acidobacteria,2JHJP@204432|Acidobacteriia	204432|Acidobacteriia	C	Delta-1-pyrroline-5-carboxylate dehydrogenase	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS2_k127_1140382_6	204669.Acid345_0401	2.503e-58	205.0	COG0745@1|root,COG0745@2|Bacteria	204669.Acid345_0401|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1140382_4	204669.Acid345_0405	5.842e-66	233.0	COG2197@1|root,COG2197@2|Bacteria,3Y4GD@57723|Acidobacteria,2JJ6Q@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_1140382_13	414684.RC1_0497	2.922e-08	62.0	2E4S1@1|root,32ZKH@2|Bacteria,1N9PR@1224|Proteobacteria,2UFAW@28211|Alphaproteobacteria,2JTZW@204441|Rhodospirillales	204441|Rhodospirillales	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
TLS2_k127_1140382_3	330214.NIDE3501	4.899e-124	424.0	COG4907@1|root,COG4907@2|Bacteria	2|Bacteria	P	membrane protein (DUF2207)	yciQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2207
TLS2_k127_1140382_7	330214.NIDE3500	2.69e-58	207.0	COG1704@1|root,COG1704@2|Bacteria	2|Bacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
TLS2_k127_1140382_12	1382305.AZUC01000053_gene2880	1.073e-08	60.0	2EFZF@1|root,339RM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1140382_0	211165.AJLN01000074_gene6344	0.0	1021.0	COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria,1JMTM@1189|Stigonemataceae	1117|Cyanobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_1140382_10	305900.GV64_06985	3.64e-22	101.0	COG3650@1|root,COG3895@1|root,COG3650@2|Bacteria,COG3895@2|Bacteria,1N019@1224|Proteobacteria,1SBAD@1236|Gammaproteobacteria,1XQ93@135619|Oceanospirillales	135619|Oceanospirillales	S	Membrane-bound lysozyme-inhibitor of c-type lysozyme	-	-	-	-	-	-	-	-	-	-	-	-	MliC
TLS2_k127_1140382_11	234267.Acid_5771	4.557e-20	100.0	COG2010@1|root,COG2010@2|Bacteria,3Y5Q0@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS2_k127_1140382_8	1142394.PSMK_26970	8.012e-56	199.0	COG0590@1|root,COG0590@2|Bacteria,2IZBJ@203682|Planctomycetes	203682|Planctomycetes	FJ	COG0590 Cytosine adenosine deaminases	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
TLS2_k127_1140382_2	886293.Sinac_3668	1.678e-135	446.0	COG0534@1|root,COG0534@2|Bacteria,2IX5Q@203682|Planctomycetes	203682|Planctomycetes	V	COG0534 Na -driven multidrug efflux pump	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
TLS2_k127_1140382_5	204669.Acid345_2682	2.345e-60	233.0	COG0515@1|root,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
TLS2_k127_1140382_9	204669.Acid345_0330	2.023e-47	175.0	2DC00@1|root,2ZC4V@2|Bacteria,3Y8QE@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1175356_0	378806.STAUR_4921	8.083e-81	286.0	COG3385@1|root,COG3385@2|Bacteria,1RK5C@1224|Proteobacteria,43CJU@68525|delta/epsilon subdivisions,2X7U7@28221|Deltaproteobacteria,2Z16K@29|Myxococcales	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
TLS2_k127_1194746_5	204669.Acid345_0072	1.835e-49	181.0	COG2199@1|root,COG3706@2|Bacteria,3Y5QC@57723|Acidobacteria,2JNT2@204432|Acidobacteriia	204432|Acidobacteriia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_1194746_1	204669.Acid345_0073	6.636e-110	370.0	COG4105@1|root,COG4105@2|Bacteria,3Y36S@57723|Acidobacteria,2JHVA@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM Outer membrane assembly lipoprotein YfiO	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
TLS2_k127_1194746_6	690597.JH730979_gene29	2.806e-06	58.0	COG3157@1|root,COG3157@2|Bacteria,1RBTU@1224|Proteobacteria,1S39K@1236|Gammaproteobacteria,1YPDG@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	type VI secretion system	-	-	-	ko:K06887,ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
TLS2_k127_1194746_3	204669.Acid345_0074	2e-97	323.0	COG0036@1|root,COG0036@2|Bacteria,3Y3YN@57723|Acidobacteria,2JIFX@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the ribulose-phosphate 3-epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TLS2_k127_1194746_2	204669.Acid345_4733	9.113e-108	356.0	COG4608@1|root,COG4608@2|Bacteria,3Y2TH@57723|Acidobacteria,2JHXB@204432|Acidobacteriia	204432|Acidobacteriia	E	ABC transporter	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran
TLS2_k127_1194746_4	204669.Acid345_0012	1.166e-58	218.0	28JCC@1|root,34374@2|Bacteria,3Y89Q@57723|Acidobacteria,2JNBF@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_1194746_0	1232410.KI421422_gene2032	6.11e-203	653.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,43SYW@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS2_k127_123216_12	204669.Acid345_2626	6.731e-67	231.0	COG0005@1|root,COG0005@2|Bacteria,3Y2MA@57723|Acidobacteria,2JI5Q@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_123216_3	204669.Acid345_2625	1.919e-130	426.0	COG0524@1|root,COG0524@2|Bacteria,3Y3GE@57723|Acidobacteria,2JHP7@204432|Acidobacteriia	204432|Acidobacteriia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS2_k127_123216_5	204669.Acid345_2624	3.208e-113	383.0	COG1807@1|root,COG1807@2|Bacteria,3Y3BJ@57723|Acidobacteria,2JI9B@204432|Acidobacteriia	204432|Acidobacteriia	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_123216_13	204669.Acid345_2623	1.332e-62	223.0	COG1285@1|root,COG1285@2|Bacteria,3Y4TX@57723|Acidobacteria,2JJM0@204432|Acidobacteriia	204432|Acidobacteriia	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
TLS2_k127_123216_7	204669.Acid345_2622	2.349e-88	298.0	COG0253@1|root,COG0253@2|Bacteria,3Y4EC@57723|Acidobacteria,2JI4R@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
TLS2_k127_123216_8	204669.Acid345_2621	8.886e-85	298.0	COG1619@1|root,COG1619@2|Bacteria,3Y3SS@57723|Acidobacteria,2JHRY@204432|Acidobacteriia	204432|Acidobacteriia	V	LD-carboxypeptidase	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
TLS2_k127_123216_0	204669.Acid345_2620	4.686e-200	638.0	COG0773@1|root,COG0773@2|Bacteria,3Y2M2@57723|Acidobacteria,2JIE2@204432|Acidobacteriia	204432|Acidobacteriia	M	Mur ligase middle domain	-	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_123216_10	1382359.JIAL01000001_gene1609	2.417e-74	258.0	COG0204@1|root,COG0204@2|Bacteria,3Y49D@57723|Acidobacteria,2JJ6K@204432|Acidobacteriia	204432|Acidobacteriia	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_123216_18	204669.Acid345_4029	3.147e-45	167.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_3,Response_reg
TLS2_k127_123216_16	1267534.KB906756_gene234	2.892e-47	176.0	29E7I@1|root,3015I@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
TLS2_k127_123216_14	204669.Acid345_1425	5.139e-62	223.0	COG2207@1|root,COG2207@2|Bacteria,3Y4S3@57723|Acidobacteria,2JJNW@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS2_k127_123216_11	204669.Acid345_2399	2.021e-69	256.0	COG0642@1|root,COG2199@1|root,COG4191@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,COG4191@2|Bacteria,3Y3F8@57723|Acidobacteria,2JKAW@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
TLS2_k127_123216_2	204669.Acid345_2893	7.925e-147	476.0	COG0513@1|root,COG0513@2|Bacteria,3Y2M6@57723|Acidobacteria,2JHVB@204432|Acidobacteriia	204432|Acidobacteriia	L	DEAD DEAH box helicase	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
TLS2_k127_123216_21	204669.Acid345_3217	3.9e-25	113.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	MtrB_PioB,OMP_b-brl
TLS2_k127_123216_19	204669.Acid345_1978	1.269e-37	148.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
TLS2_k127_123216_1	204669.Acid345_1975	1.973e-181	587.0	COG2812@1|root,COG2812@2|Bacteria,3Y3C4@57723|Acidobacteria,2JHPD@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
TLS2_k127_123216_20	204669.Acid345_1974	2.242e-30	137.0	COG0718@1|root,COG0718@2|Bacteria,3Y5CB@57723|Acidobacteria,2JJRM@204432|Acidobacteriia	204432|Acidobacteriia	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
TLS2_k127_123216_6	204669.Acid345_1973	3.267e-98	323.0	COG0353@1|root,COG0353@2|Bacteria,3Y31E@57723|Acidobacteria,2JHQM@204432|Acidobacteriia	204432|Acidobacteriia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
TLS2_k127_123216_15	204669.Acid345_1970	6.558e-60	209.0	COG0745@1|root,COG0745@2|Bacteria,3Y4TZ@57723|Acidobacteria,2JJI7@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_123216_23	251229.Chro_2927	7.745e-05	55.0	COG2948@1|root,COG2948@2|Bacteria,1G633@1117|Cyanobacteria,3VJQM@52604|Pleurocapsales	1117|Cyanobacteria	U	multi-organism process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_123216_17	1382359.JIAL01000001_gene377	9.862e-46	175.0	COG2940@1|root,COG2940@2|Bacteria,3Y5G7@57723|Acidobacteria,2JMXZ@204432|Acidobacteriia	204432|Acidobacteriia	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
TLS2_k127_123216_9	204669.Acid345_0969	5.155e-80	282.0	2C89V@1|root,34AEG@2|Bacteria,3Y8IH@57723|Acidobacteria,2JNND@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_123216_4	204669.Acid345_3327	1.401e-128	437.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	HemolysinCabind,Metallophos
TLS2_k127_1255646_3	204669.Acid345_4326	4.331e-77	262.0	COG1235@1|root,COG1235@2|Bacteria,3Y3DW@57723|Acidobacteria,2JI3X@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_1255646_11	56780.SYN_01756	4.871e-05	56.0	COG4726@1|root,COG4726@2|Bacteria,1NK1B@1224|Proteobacteria	1224|Proteobacteria	NU	Pilus assembly protein PilX	-	-	-	ko:K02673	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilX_N
TLS2_k127_1255646_10	335543.Sfum_2553	1.583e-06	59.0	COG4966@1|root,COG4966@2|Bacteria,1Q8WE@1224|Proteobacteria,439J3@68525|delta/epsilon subdivisions,2X4VK@28221|Deltaproteobacteria,2MSHQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
TLS2_k127_1255646_9	177437.HRM2_27690	9.138e-07	59.0	COG4970@1|root,COG4970@2|Bacteria,1Q0DU@1224|Proteobacteria,42W7A@68525|delta/epsilon subdivisions,2WS6U@28221|Deltaproteobacteria,2MKVN@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Type II transport protein GspH	-	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
TLS2_k127_1255646_5	1382359.JIAL01000001_gene1568	9.058e-64	230.0	COG0797@1|root,COG0797@2|Bacteria,3Y4FC@57723|Acidobacteria,2JJ4X@204432|Acidobacteriia	204432|Acidobacteriia	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
TLS2_k127_1255646_6	204669.Acid345_0787	9.333e-50	187.0	COG0537@1|root,COG0537@2|Bacteria,3Y542@57723|Acidobacteria,2JJT8@204432|Acidobacteriia	204432|Acidobacteriia	FG	PFAM Histidine triad (HIT) protein	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
TLS2_k127_1255646_4	204669.Acid345_0785	6.779e-67	235.0	29ITM@1|root,305QZ@2|Bacteria,3Y4F3@57723|Acidobacteria,2JJ2C@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1255646_0	1340493.JNIF01000003_gene1819	0.0	1431.0	COG2911@1|root,COG4775@1|root,COG2911@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K07277,ko:K09800	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	AsmA_2,Bac_surface_Ag,DUF748,POTRA,TamB
TLS2_k127_1255646_1	1267534.KB906755_gene4695	3.366e-252	799.0	COG1629@1|root,COG4771@2|Bacteria,3Y33S@57723|Acidobacteria,2JK9M@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_1257223_9	867845.KI911784_gene2431	1.895e-36	145.0	COG0391@1|root,COG0391@2|Bacteria,2G5S2@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM LPPG domain protein containing protein	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
TLS2_k127_1257223_4	1382356.JQMP01000001_gene1156	1.998e-129	425.0	COG1060@1|root,COG1060@2|Bacteria,2G7YI@200795|Chloroflexi,27YSR@189775|Thermomicrobia	189775|Thermomicrobia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
TLS2_k127_1257223_3	686340.Metal_3938	1.258e-133	435.0	COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,1RMMZ@1236|Gammaproteobacteria,1XG2S@135618|Methylococcales	135618|Methylococcales	IQ	PFAM short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_1257223_12	555079.Toce_0720	1.897e-07	60.0	COG3350@1|root,COG3350@2|Bacteria,1VKZJ@1239|Firmicutes,24VQV@186801|Clostridia,42HIA@68295|Thermoanaerobacterales	186801|Clostridia	S	pfam yhs	-	-	-	-	-	-	-	-	-	-	-	-	YHS
TLS2_k127_1257223_6	204669.Acid345_0812	1.988e-52	193.0	COG5637@1|root,COG5637@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	BON,DUF2892,Polyketide_cyc,Polyketide_cyc2
TLS2_k127_1257223_11	1267533.KB906740_gene171	1.85e-17	90.0	295XS@1|root,2ZT8N@2|Bacteria,3Y8UF@57723|Acidobacteria,2JNQH@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1257223_5	204669.Acid345_0810	7.712e-72	265.0	COG0810@1|root,COG0810@2|Bacteria,3Y8PD@57723|Acidobacteria	57723|Acidobacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
TLS2_k127_1257223_1	1267533.KB906741_gene515	1.002e-272	848.0	COG0568@1|root,COG0568@2|Bacteria,3Y2XG@57723|Acidobacteria,2JHX1@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_1257223_2	204669.Acid345_4297	1.674e-219	698.0	COG0358@1|root,COG0358@2|Bacteria,3Y366@57723|Acidobacteria,2JIHT@204432|Acidobacteriia	204432|Acidobacteriia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_N,zf-CHC2
TLS2_k127_1257223_10	204669.Acid345_1345	9.368e-21	107.0	COG1361@1|root,COG1572@1|root,COG3712@1|root,COG1361@2|Bacteria,COG1572@2|Bacteria,COG3712@2|Bacteria	2|Bacteria	PT	iron ion homeostasis	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	DUF11,FecR
TLS2_k127_1257223_7	1303692.SFUL_150	6.241e-45	173.0	COG4899@1|root,COG4899@2|Bacteria,2IGN5@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2199)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2199
TLS2_k127_1257223_0	204669.Acid345_4299	3e-323	1013.0	COG1193@1|root,COG1193@2|Bacteria,3Y2Z2@57723|Acidobacteria,2JHU4@204432|Acidobacteriia	204432|Acidobacteriia	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
TLS2_k127_1257223_8	204669.Acid345_4300	1.199e-40	154.0	COG0113@1|root,COG0113@2|Bacteria,3Y2VK@57723|Acidobacteria,2JIFQ@204432|Acidobacteriia	204432|Acidobacteriia	H	Delta-aminolevulinic acid dehydratase	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
TLS2_k127_1258826_2	1382359.JIAL01000001_gene2075	2.155e-93	314.0	COG2234@1|root,COG2234@2|Bacteria,3Y53E@57723|Acidobacteria,2JKAS@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_1258826_0	234267.Acid_4321	3.541e-109	377.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_1258826_3	234267.Acid_4320	1.18e-82	282.0	COG0745@1|root,COG0745@2|Bacteria,3Y4D1@57723|Acidobacteria	57723|Acidobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_1258826_1	1047013.AQSP01000125_gene2637	5.618e-103	362.0	COG0823@1|root,COG4946@1|root,COG0823@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Amidohydro_1,PD40,PG_binding_1,Pkinase,TolB_N
TLS2_k127_1258826_4	530564.Psta_3944	2.663e-81	284.0	COG1858@1|root,COG1858@2|Bacteria,2IY7G@203682|Planctomycetes	203682|Planctomycetes	C	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
TLS2_k127_1276565_24	1114970.PSF113_1852	4.097e-05	53.0	2DEJM@1|root,2ZN8P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1276565_11	1121918.ARWE01000001_gene2756	1.349e-72	258.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,42P0U@68525|delta/epsilon subdivisions,2WJC6@28221|Deltaproteobacteria,43T6F@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_1276565_18	443143.GM18_2556	2.098e-31	131.0	COG0586@1|root,COG0586@2|Bacteria,1NBBA@1224|Proteobacteria,42MFR@68525|delta/epsilon subdivisions,2WR9B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_1276565_19	204669.Acid345_4356	1.92e-30	120.0	COG1278@1|root,COG1278@2|Bacteria,3Y57X@57723|Acidobacteria	57723|Acidobacteria	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_1276565_13	483219.LILAB_18780	3.782e-60	214.0	COG3005@1|root,COG3005@2|Bacteria,1N0I4@1224|Proteobacteria,42R1B@68525|delta/epsilon subdivisions,2WSF5@28221|Deltaproteobacteria,2Z0Q9@29|Myxococcales	28221|Deltaproteobacteria	C	cytochrome c nitrite reductase	-	-	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT
TLS2_k127_1276565_0	497964.CfE428DRAFT_1132	4.941e-204	645.0	COG3303@1|root,COG3303@2|Bacteria,46UP1@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552
TLS2_k127_1276565_4	649638.Trad_1499	1.34e-154	503.0	COG1620@1|root,COG1620@2|Bacteria,1WMUR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	COGs COG1620 L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
TLS2_k127_1276565_17	523841.HFX_3023	9.479e-34	141.0	COG1814@1|root,arCOG01096@2157|Archaea,2XWMJ@28890|Euryarchaeota,23V7P@183963|Halobacteria	183963|Halobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
TLS2_k127_1276565_20	1267533.KB906734_gene3899	2.475e-29	130.0	2DXMA@1|root,345IN@2|Bacteria,3Y8DJ@57723|Acidobacteria,2JNF0@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1276565_21	682795.AciX8_1715	1.59e-22	113.0	2EQIM@1|root,33I4N@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
TLS2_k127_1276565_14	1267533.KB906734_gene3897	6.236e-58	226.0	2DS8I@1|root,33F02@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
TLS2_k127_1276565_6	682795.AciX8_1713	7.16e-123	401.0	COG0714@1|root,COG0714@2|Bacteria,3Y4G8@57723|Acidobacteria,2JKTE@204432|Acidobacteriia	204432|Acidobacteriia	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_1276565_8	1267533.KB906734_gene3895	1.851e-115	400.0	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF58
TLS2_k127_1276565_9	1267533.KB906734_gene3892	5.58e-100	335.0	COG1300@1|root,COG1300@2|Bacteria	2|Bacteria	CP	Membrane	-	-	-	ko:K06384	-	-	-	-	ko00000	-	-	-	SpoIIM
TLS2_k127_1276565_16	1267533.KB906734_gene3891	1.492e-48	183.0	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS2_k127_1276565_12	648757.Rvan_3031	8.582e-67	233.0	COG1225@1|root,COG1225@2|Bacteria,1RD2X@1224|Proteobacteria,2U7PM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG0526 Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_1276565_1	309807.SRU_2711	3.899e-189	613.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,4NEW6@976|Bacteroidetes,1FJJN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	CO	Disulphide bond corrector protein DsbC	-	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
TLS2_k127_1276565_23	390989.JOEG01000001_gene4805	1.008e-11	74.0	COG2353@1|root,COG2353@2|Bacteria,2GJUB@201174|Actinobacteria,4D9KN@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the UPF0312 family	yceI	-	-	-	-	-	-	-	-	-	-	-	YceI
TLS2_k127_1276565_15	221288.JH992900_gene319	8.098e-58	204.0	COG4288@1|root,COG4288@2|Bacteria,1G65D@1117|Cyanobacteria,1JKYE@1189|Stigonemataceae	1117|Cyanobacteria	S	Anabaena sensory rhodopsin transducer	-	-	-	-	-	-	-	-	-	-	-	-	ASRT
TLS2_k127_1276565_10	745310.G432_16740	1.374e-98	346.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2TSHC@28211|Alphaproteobacteria,2K0UX@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_1276565_5	234267.Acid_2315	5.906e-154	524.0	COG2120@1|root,COG2120@2|Bacteria,3Y3BV@57723|Acidobacteria	57723|Acidobacteria	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_1276565_2	1379270.AUXF01000002_gene1730	2.971e-177	574.0	COG0591@1|root,COG0591@2|Bacteria,1ZT93@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_1276565_7	204669.Acid345_3144	7.679e-118	400.0	COG1680@1|root,COG1680@2|Bacteria,3Y7DP@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_1276565_3	880073.Calab_2338	2.401e-155	505.0	COG1282@1|root,COG1282@2|Bacteria,2NQMF@2323|unclassified Bacteria	2|Bacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
TLS2_k127_1277620_4	1445613.JALM01000009_gene627	4.693e-10	61.0	2EIN9@1|root,33CDK@2|Bacteria,2GJCX@201174|Actinobacteria,4E1QE@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SBP56
TLS2_k127_1277620_1	1267535.KB906767_gene1522	3.646e-120	392.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS2_k127_1277620_2	204669.Acid345_3039	2.133e-117	404.0	28NTH@1|root,2ZBS4@2|Bacteria,3Y3NN@57723|Acidobacteria,2JIEU@204432|Acidobacteriia	204432|Acidobacteriia	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TLS2_k127_1277620_3	204669.Acid345_1345	9.823e-40	169.0	COG1361@1|root,COG1572@1|root,COG3712@1|root,COG1361@2|Bacteria,COG1572@2|Bacteria,COG3712@2|Bacteria	2|Bacteria	PT	iron ion homeostasis	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	DUF11,FecR
TLS2_k127_1277620_0	1267534.KB906754_gene3448	2.86e-259	825.0	COG0557@1|root,COG0557@2|Bacteria,3Y3TF@57723|Acidobacteria,2JIM3@204432|Acidobacteriia	204432|Acidobacteriia	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
TLS2_k127_1289944_7	204669.Acid345_0557	3.05e-95	317.0	COG1559@1|root,COG1559@2|Bacteria,3Y2RD@57723|Acidobacteria,2JIQ0@204432|Acidobacteriia	204432|Acidobacteriia	M	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
TLS2_k127_1289944_6	204669.Acid345_0558	1.247e-100	338.0	COG2834@1|root,COG2834@2|Bacteria,3Y4A1@57723|Acidobacteria,2JJ5F@204432|Acidobacteriia	204432|Acidobacteriia	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4292
TLS2_k127_1289944_3	204669.Acid345_0559	1.848e-130	427.0	COG4591@1|root,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,LolA_like,MacB_PCD
TLS2_k127_1289944_9	204669.Acid345_0561	2.171e-58	209.0	COG0102@1|root,COG0102@2|Bacteria,3Y4U5@57723|Acidobacteria,2JJGG@204432|Acidobacteriia	204432|Acidobacteriia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
TLS2_k127_1289944_10	204669.Acid345_0562	1.926e-53	190.0	COG0103@1|root,COG0103@2|Bacteria,3Y4IK@57723|Acidobacteria,2JJ7P@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
TLS2_k127_1289944_1	204669.Acid345_0563	3.78e-135	436.0	COG0052@1|root,COG0052@2|Bacteria,3Y3K2@57723|Acidobacteria,2JI0A@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
TLS2_k127_1289944_5	204669.Acid345_0565	1.45e-103	340.0	COG0264@1|root,COG0264@2|Bacteria,3Y3BT@57723|Acidobacteria,2JIX3@204432|Acidobacteriia	204432|Acidobacteriia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
TLS2_k127_1289944_2	1211115.ALIQ01000018_gene2164	1.37e-130	436.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	glucose sorbosone	yliI	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363	1.1.5.2	ko:K00117,ko:K21430	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	GSDH
TLS2_k127_1289944_4	204669.Acid345_0259	3.207e-110	367.0	COG0528@1|root,COG0528@2|Bacteria,3Y2FI@57723|Acidobacteria,2JISS@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS2_k127_1289944_8	204669.Acid345_0261	9.863e-79	267.0	COG0233@1|root,COG0233@2|Bacteria,3Y4AP@57723|Acidobacteria,2JJ0X@204432|Acidobacteriia	204432|Acidobacteriia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
TLS2_k127_1289944_0	204669.Acid345_0248	0.0	1182.0	COG4775@1|root,COG4775@2|Bacteria,3Y2Q9@57723|Acidobacteria,2JHYD@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM outer membrane protein assembly complex, YaeT protein	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TLS2_k127_129372_0	240015.ACP_0459	5.202e-151	482.0	COG0214@1|root,COG0214@2|Bacteria,3Y3ST@57723|Acidobacteria,2JKN5@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the PdxS SNZ family	-	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
TLS2_k127_129372_1	204669.Acid345_1854	1.096e-35	138.0	COG2050@1|root,COG2050@2|Bacteria,3Y57I@57723|Acidobacteria,2JJU4@204432|Acidobacteriia	204432|Acidobacteriia	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_1304093_29	1183438.GKIL_2517	3.15e-84	284.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TLS2_k127_1304093_24	1267535.KB906767_gene632	1.761e-108	366.0	COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria,2JIKD@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1304093_15	452637.Oter_1883	1.194e-179	597.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_1304093_10	1267535.KB906767_gene5449	3.956e-187	613.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_1304093_6	251221.35211765	2.313e-197	646.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_1304093_17	1183438.GKIL_4354	2.036e-173	582.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_1304093_8	234267.Acid_1737	1.576e-193	632.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_1304093_12	1183438.GKIL_4354	1.819e-181	595.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_1304093_4	234267.Acid_3991	6.315e-207	670.0	COG0577@1|root,COG0577@2|Bacteria,3Y44G@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_1304093_9	861299.J421_0282	7.959e-188	615.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_1304093_11	251221.35211765	4.548e-182	598.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_1304093_25	1382359.JIAL01000001_gene2773	4.842e-102	337.0	COG1136@1|root,COG1136@2|Bacteria,3Y2X0@57723|Acidobacteria,2JHYU@204432|Acidobacteriia	204432|Acidobacteriia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_1304093_14	204669.Acid345_1445	5.482e-180	584.0	COG1538@1|root,COG1538@2|Bacteria,3Y2NZ@57723|Acidobacteria,2JI75@204432|Acidobacteriia	204432|Acidobacteriia	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS2_k127_1304093_13	926566.Terro_2393	4.086e-180	574.0	COG2204@1|root,COG2204@2|Bacteria,3Y33M@57723|Acidobacteria,2JHW9@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_1304093_18	234267.Acid_4169	5.381e-150	487.0	COG5000@1|root,COG5000@2|Bacteria,3Y2TD@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
TLS2_k127_1304093_21	204669.Acid345_0817	5.185e-121	414.0	COG0535@1|root,COG0535@2|Bacteria,3Y2KT@57723|Acidobacteria,2JIDX@204432|Acidobacteriia	204432|Acidobacteriia	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
TLS2_k127_1304093_41	204669.Acid345_2960	3.056e-33	134.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS2_k127_1304093_27	204669.Acid345_2959	7.701e-95	318.0	COG0500@1|root,COG2226@2|Bacteria,3Y4HC@57723|Acidobacteria,2JKIK@204432|Acidobacteriia	204432|Acidobacteriia	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
TLS2_k127_1304093_32	1049564.TevJSym_ar00200	2.059e-68	242.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,1RR4R@1236|Gammaproteobacteria,1J613@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane protein, hemolysin III homolog	yqfA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
TLS2_k127_1304093_2	1379270.AUXF01000001_gene2161	7.143e-238	776.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_6,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
TLS2_k127_1304093_35	211165.AJLN01000107_gene5629	6.067e-57	208.0	COG1926@1|root,COG1926@2|Bacteria,1G2IS@1117|Cyanobacteria,1JKQX@1189|Stigonemataceae	1117|Cyanobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
TLS2_k127_1304093_16	204669.Acid345_2712	4.952e-177	569.0	COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria,2JJ6B@204432|Acidobacteriia	57723|Acidobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
TLS2_k127_1304093_7	204669.Acid345_2713	2.804e-195	629.0	COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,3Y6QW@57723|Acidobacteria	57723|Acidobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB
TLS2_k127_1304093_48	1267534.KB906760_gene1234	1.359e-16	84.0	COG2010@1|root,COG2010@2|Bacteria,3Y5MU@57723|Acidobacteria,2JJWK@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS2_k127_1304093_22	671143.DAMO_0822	2.41e-111	377.0	COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
TLS2_k127_1304093_20	1379698.RBG1_1C00001G0780	8.148e-127	419.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petB	-	-	ko:K00410,ko:K00412,ko:K02635,ko:K02637	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	-	-	ko00000,ko00001,ko00002,ko00194,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
TLS2_k127_1304093_38	1379698.RBG1_1C00001G0781	1.244e-44	170.0	COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria	2|Bacteria	C	Rieske [2Fe-2S] domain	petA	-	1.10.2.2,1.10.9.1	ko:K00411,ko:K02636,ko:K03886	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske,UCR_Fe-S_N
TLS2_k127_1304093_47	1382359.JIAL01000001_gene323	1.626e-17	89.0	COG2010@1|root,COG2010@2|Bacteria,3Y5MU@57723|Acidobacteria,2JJWK@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS2_k127_1304093_19	401053.AciPR4_1213	4.009e-140	473.0	28MCK@1|root,2ZAQP@2|Bacteria,3Y41I@57723|Acidobacteria,2JI2I@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1304093_26	204669.Acid345_3828	9.252e-97	326.0	COG3303@1|root,COG3303@2|Bacteria,3Y999@57723|Acidobacteria,2JP5G@204432|Acidobacteriia	204432|Acidobacteriia	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
TLS2_k127_1304093_0	1173028.ANKO01000017_gene231	0.0	1150.0	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria,1H81U@1150|Oscillatoriales	1117|Cyanobacteria	CJ	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
TLS2_k127_1304093_43	1120965.AUBV01000006_gene2374	1.239e-30	127.0	COG1764@1|root,COG1764@2|Bacteria,4P9T2@976|Bacteroidetes,47S0N@768503|Cytophagia	976|Bacteroidetes	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_1304093_49	1267533.KB906735_gene5029	2.317e-06	53.0	2ETYG@1|root,33MFK@2|Bacteria,3Y604@57723|Acidobacteria,2JK68@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1304093_42	204669.Acid345_0071	2.444e-31	135.0	COG0589@1|root,COG0589@2|Bacteria,3Y5Y7@57723|Acidobacteria,2JK6C@204432|Acidobacteriia	204432|Acidobacteriia	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_1304093_23	1415166.NONO_c48570	9.843e-111	372.0	COG4097@1|root,COG4097@2|Bacteria,2H9AX@201174|Actinobacteria,4FVV7@85025|Nocardiaceae	201174|Actinobacteria	P	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_8,Ferric_reduct,NAD_binding_1
TLS2_k127_1304093_30	204669.Acid345_3455	1.165e-80	276.0	COG0664@1|root,COG0664@2|Bacteria,3Y4IX@57723|Acidobacteria,2JJ9U@204432|Acidobacteriia	204432|Acidobacteriia	K	cyclic nucleotide-binding	-	-	-	ko:K01420,ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_1304093_1	483219.LILAB_26095	0.0	1028.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2YUAS@29|Myxococcales	28221|Deltaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS2_k127_1304093_28	1123229.AUBC01000011_gene2484	4.191e-90	314.0	COG1052@1|root,COG1052@2|Bacteria,1MVSS@1224|Proteobacteria,2VFXB@28211|Alphaproteobacteria,3JX4B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_1304093_36	204669.Acid345_2941	4.269e-55	204.0	COG0589@1|root,COG0589@2|Bacteria,3Y5Y7@57723|Acidobacteria,2JK6C@204432|Acidobacteriia	204432|Acidobacteriia	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_1304093_31	204669.Acid345_3455	9.69e-77	263.0	COG0664@1|root,COG0664@2|Bacteria,3Y4IX@57723|Acidobacteria,2JJ9U@204432|Acidobacteriia	204432|Acidobacteriia	K	cyclic nucleotide-binding	-	-	-	ko:K01420,ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_1304093_45	204669.Acid345_1498	1.034e-19	95.0	COG0664@1|root,COG0664@2|Bacteria,3Y4IX@57723|Acidobacteria,2JJ9U@204432|Acidobacteriia	204432|Acidobacteriia	K	cyclic nucleotide-binding	-	-	-	ko:K01420,ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_1304093_33	926560.KE387023_gene2884	2.864e-67	233.0	COG2318@1|root,COG2318@2|Bacteria,1WMM8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_1304093_46	1111730.ATTM01000008_gene714	1.563e-18	89.0	2E3Q4@1|root,32YN3@2|Bacteria,4NVYD@976|Bacteroidetes,1IE48@117743|Flavobacteriia,2NZU2@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1304093_3	204669.Acid345_3662	1.804e-229	715.0	COG0499@1|root,COG0499@2|Bacteria,3Y2J2@57723|Acidobacteria,2JIFV@204432|Acidobacteriia	204432|Acidobacteriia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS2_k127_1304093_5	204669.Acid345_3661	8.661e-204	639.0	COG0192@1|root,COG0192@2|Bacteria,3Y45C@57723|Acidobacteria,2JJ0A@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
TLS2_k127_1304093_34	639030.JHVA01000001_gene3458	5.251e-60	228.0	COG2856@1|root,COG2856@2|Bacteria,3Y3ZJ@57723|Acidobacteria,2JIJ0@204432|Acidobacteriia	204432|Acidobacteriia	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1304093_40	1267534.KB906754_gene3358	9.808e-36	150.0	28QZS@1|root,2ZDEJ@2|Bacteria,3Y4BV@57723|Acidobacteria,2JK72@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1304093_37	530564.Psta_3944	2.297e-52	192.0	COG1858@1|root,COG1858@2|Bacteria,2IY7G@203682|Planctomycetes	203682|Planctomycetes	C	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
TLS2_k127_1321154_1	204669.Acid345_2459	9.59e-206	647.0	COG0403@1|root,COG0403@2|Bacteria,3Y2WZ@57723|Acidobacteria,2JIU3@204432|Acidobacteriia	204432|Acidobacteriia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
TLS2_k127_1321154_0	204669.Acid345_2458	1.447e-267	830.0	COG1003@1|root,COG1003@2|Bacteria,3Y2UZ@57723|Acidobacteria,2JIAN@204432|Acidobacteriia	204432|Acidobacteriia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
TLS2_k127_1321154_3	765420.OSCT_2410	1.783e-51	186.0	COG0614@1|root,COG0614@2|Bacteria,2G9KR@200795|Chloroflexi,377DT@32061|Chloroflexia	32061|Chloroflexia	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
TLS2_k127_1321154_2	1123368.AUIS01000019_gene1214	1.152e-125	409.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,1RNCM@1236|Gammaproteobacteria,2NE5Q@225057|Acidithiobacillales	1236|Gammaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_1325489_2	204669.Acid345_3348	8.052e-85	289.0	COG0030@1|root,COG0030@2|Bacteria,3Y3RQ@57723|Acidobacteria,2JIX1@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TLS2_k127_1325489_0	204669.Acid345_3349	9.846e-244	764.0	COG0297@1|root,COG0297@2|Bacteria,3Y3IH@57723|Acidobacteria,2JHNU@204432|Acidobacteriia	204432|Acidobacteriia	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
TLS2_k127_1325489_1	204669.Acid345_3351	4.714e-191	608.0	COG0531@1|root,COG0531@2|Bacteria,3Y2T1@57723|Acidobacteria,2JI3B@204432|Acidobacteriia	204432|Acidobacteriia	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_1325489_3	278963.ATWD01000002_gene410	2.267e-34	136.0	COG0591@1|root,COG1680@1|root,COG3876@1|root,COG0591@2|Bacteria,COG1680@2|Bacteria,COG3876@2|Bacteria,3Y3MK@57723|Acidobacteria,2JP3A@204432|Acidobacteriia	204432|Acidobacteriia	EV	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343,SSF
TLS2_k127_1326439_0	306281.AJLK01000032_gene1577	1.181e-283	884.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1G1Q1@1117|Cyanobacteria	1117|Cyanobacteria	EU	PFAM Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
TLS2_k127_1326439_1	204669.Acid345_2683	1.262e-116	383.0	COG3103@1|root,COG4991@2|Bacteria,3Y7ER@57723|Acidobacteria,2JM8Z@204432|Acidobacteriia	204432|Acidobacteriia	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1326439_2	1121939.L861_10155	3.288e-54	201.0	COG3963@1|root,COG3963@2|Bacteria,1RATY@1224|Proteobacteria,1S1YM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	methyltransferase	ksgA1	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,RrnaAD
TLS2_k127_1326439_3	1382359.JIAL01000001_gene2750	2.621e-35	146.0	COG1965@1|root,COG1965@2|Bacteria,3Y5BU@57723|Acidobacteria,2JJSI@204432|Acidobacteriia	204432|Acidobacteriia	P	Frataxin-like domain	-	-	-	ko:K06202	-	-	-	-	ko00000	-	-	-	Frataxin_Cyay
TLS2_k127_1326439_4	401053.AciPR4_1484	4.851e-05	50.0	COG2304@1|root,COG2304@2|Bacteria,3Y3QQ@57723|Acidobacteria,2JHV1@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
TLS2_k127_1398203_2	204669.Acid345_3966	2.649e-62	219.0	COG1664@1|root,COG1664@2|Bacteria,3Y49V@57723|Acidobacteria,2JJ4E@204432|Acidobacteriia	204432|Acidobacteriia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS2_k127_1398203_5	234267.Acid_4758	2.709e-06	52.0	2C7DG@1|root,2ZTXV@2|Bacteria,3Y94Z@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1398203_0	204669.Acid345_3967	3.747e-189	606.0	COG0728@1|root,COG0728@2|Bacteria,3Y31G@57723|Acidobacteria,2JI21@204432|Acidobacteriia	204432|Acidobacteriia	S	virulence factor MVIN family protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TLS2_k127_1398203_4	266117.Rxyl_2362	1.262e-26	112.0	COG2128@1|root,COG2128@2|Bacteria,2I829@201174|Actinobacteria,4CTTA@84995|Rubrobacteria	84995|Rubrobacteria	S	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_1398203_6	345341.KUTG_03230	2.815e-05	49.0	COG2128@1|root,COG2128@2|Bacteria,2I829@201174|Actinobacteria,4E36F@85010|Pseudonocardiales	201174|Actinobacteria	S	carboxymuconolactone decarboxylase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	CMD
TLS2_k127_1398203_3	1379698.RBG1_1C00001G0336	1.334e-31	132.0	COG5588@1|root,COG5588@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
TLS2_k127_1398203_1	1267535.KB906767_gene737	1.113e-74	258.0	COG0225@1|root,COG0225@2|Bacteria,3Y4DM@57723|Acidobacteria,2JJ10@204432|Acidobacteriia	204432|Acidobacteriia	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS2_k127_143481_2	1121920.AUAU01000006_gene330	1.427e-05	48.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y6VR@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_143481_0	204669.Acid345_3936	0.0	1045.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y6VR@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_143481_1	1242864.D187_000036	1.76e-67	238.0	COG2267@1|root,COG2267@2|Bacteria,1R08U@1224|Proteobacteria,42XGE@68525|delta/epsilon subdivisions,2X8N8@28221|Deltaproteobacteria,2Z36G@29|Myxococcales	28221|Deltaproteobacteria	I	Pfam:DUF2305	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_1468567_2	204669.Acid345_0062	2.792e-105	361.0	COG0037@1|root,COG0037@2|Bacteria,3Y2F2@57723|Acidobacteria,2JHX8@204432|Acidobacteriia	204432|Acidobacteriia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS_C
TLS2_k127_1468567_4	204669.Acid345_0063	5.511e-54	197.0	COG0634@1|root,COG0634@2|Bacteria	2|Bacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	GO:0000287,GO:0003674,GO:0003824,GO:0004422,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006166,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032261,GO:0032263,GO:0032264,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043167,GO:0043169,GO:0043173,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS2_k127_1468567_0	204669.Acid345_0064	1.465e-319	987.0	COG0465@1|root,COG0465@2|Bacteria,3Y2UK@57723|Acidobacteria,2JI9D@204432|Acidobacteriia	204432|Acidobacteriia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TLS2_k127_1468567_1	251221.35212217	9.792e-153	498.0	COG0531@1|root,COG0531@2|Bacteria,1G2GM@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_1468567_3	1173026.Glo7428_2591	1.246e-67	240.0	COG2890@1|root,COG2890@2|Bacteria,1G51W@1117|Cyanobacteria	1117|Cyanobacteria	J	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_1468567_5	395963.Bind_0754	7.959e-19	95.0	2DT0H@1|root,33I61@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1503153_0	204669.Acid345_1782	0.0	1049.0	COG0556@1|root,COG0556@2|Bacteria,3Y31K@57723|Acidobacteria,2JHY9@204432|Acidobacteriia	204432|Acidobacteriia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
TLS2_k127_1503153_1	1267535.KB906767_gene656	5.789e-230	722.0	COG1032@1|root,COG1032@2|Bacteria,3Y2FN@57723|Acidobacteria,2JI6W@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_1503153_2	99598.Cal7507_0941	6.703e-118	388.0	COG2303@1|root,COG2303@2|Bacteria,1FZYZ@1117|Cyanobacteria,1HJV8@1161|Nostocales	1117|Cyanobacteria	E	Belongs to the GMC oxidoreductase family	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_1510101_1	1173029.JH980292_gene2497	3.824e-58	218.0	COG0392@1|root,COG0392@2|Bacteria,1GAD9@1117|Cyanobacteria,1HDT1@1150|Oscillatoriales	1117|Cyanobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS2_k127_1510101_0	272134.KB731324_gene4071	4.608e-117	386.0	COG0726@1|root,COG0726@2|Bacteria,1G3JU@1117|Cyanobacteria,1HABD@1150|Oscillatoriales	1117|Cyanobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_1510101_2	118166.JH976537_gene15	9.915e-54	193.0	COG1232@1|root,COG1232@2|Bacteria,1G465@1117|Cyanobacteria,1H9AU@1150|Oscillatoriales	1117|Cyanobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS2_k127_1510564_0	1267535.KB906767_gene4758	1.551e-141	455.0	COG0365@1|root,COG0365@2|Bacteria,3Y39K@57723|Acidobacteria,2JI3Z@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_1510564_2	373994.Riv7116_1490	2.878e-16	83.0	COG4747@1|root,COG4747@2|Bacteria,1GEKW@1117|Cyanobacteria	1117|Cyanobacteria	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1510564_1	525904.Tter_0568	1.06e-46	172.0	COG0247@1|root,COG0247@2|Bacteria,2NNXS@2323|unclassified Bacteria	2|Bacteria	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_17,Fer4_7,Fer4_8
TLS2_k127_1581692_2	234267.Acid_5685	8.884e-14	83.0	COG1143@1|root,COG1143@2|Bacteria,3Y529@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
TLS2_k127_1581692_1	204669.Acid345_1290	6.117e-181	585.0	COG1005@1|root,COG1005@2|Bacteria,3Y3XZ@57723|Acidobacteria,2JMGA@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS2_k127_1581692_0	204669.Acid345_1289	1.196e-209	656.0	COG0649@1|root,COG0649@2|Bacteria,3Y3AB@57723|Acidobacteria,2JKWC@204432|Acidobacteriia	204432|Acidobacteriia	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS2_k127_1608270_5	1382359.JIAL01000001_gene1485	3.717e-09	58.0	2EKUV@1|root,33EIF@2|Bacteria,3Y5VB@57723|Acidobacteria,2JK46@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1608270_0	1267535.KB906767_gene1001	2.501e-229	744.0	COG0210@1|root,COG0210@2|Bacteria,3Y2W8@57723|Acidobacteria,2JIDH@204432|Acidobacteriia	204432|Acidobacteriia	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS2_k127_1608270_2	204669.Acid345_0049	9.412e-50	180.0	COG3536@1|root,COG3536@2|Bacteria,3Y4UI@57723|Acidobacteria,2JJF2@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
TLS2_k127_1608270_3	204669.Acid345_0165	1.539e-29	118.0	COG0227@1|root,COG0227@2|Bacteria,3Y5KC@57723|Acidobacteria,2JJYY@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
TLS2_k127_1608270_4	153721.MYP_861	2.823e-16	86.0	28JUV@1|root,30VEM@2|Bacteria,4NY80@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1608270_1	861299.J421_1756	1.163e-57	207.0	COG0624@1|root,COG0624@2|Bacteria,1ZUA4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_1708663_13	1340493.JNIF01000003_gene1650	2.391e-44	164.0	COG0838@1|root,COG0838@2|Bacteria,3Y5CV@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TLS2_k127_1708663_10	204669.Acid345_1314	3.677e-63	220.0	COG0852@1|root,COG0852@2|Bacteria,3Y4IQ@57723|Acidobacteria,2JJCT@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TLS2_k127_1708663_4	204669.Acid345_1313	4.45e-210	659.0	COG0649@1|root,COG0649@2|Bacteria,3Y3N1@57723|Acidobacteria,2JIDU@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
TLS2_k127_1708663_9	204669.Acid345_1312	2.897e-73	249.0	COG1905@1|root,COG1905@2|Bacteria,3Y4SI@57723|Acidobacteria,2JJDP@204432|Acidobacteriia	204432|Acidobacteriia	C	TIGRFAM NADH-quinone oxidoreductase, E subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
TLS2_k127_1708663_2	204669.Acid345_1311	1.049e-239	745.0	COG1894@1|root,COG1894@2|Bacteria,3Y2NM@57723|Acidobacteria,2JI09@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
TLS2_k127_1708663_0	204669.Acid345_1309	0.0	1165.0	COG3383@1|root,COG3383@2|Bacteria,3Y2T6@57723|Acidobacteria,2JIAG@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_10,Fer4_6,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
TLS2_k127_1708663_6	1382359.JIAL01000001_gene2022	2.372e-130	426.0	COG1005@1|root,COG1005@2|Bacteria,3Y3VS@57723|Acidobacteria,2JHQZ@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS2_k127_1708663_11	204669.Acid345_1307	1.642e-49	195.0	COG0839@1|root,COG0839@2|Bacteria,3Y4I4@57723|Acidobacteria,2JJ8B@204432|Acidobacteriia	204432|Acidobacteriia	C	plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS2_k127_1708663_14	204669.Acid345_1306	1.059e-38	146.0	COG0713@1|root,COG0713@2|Bacteria,3Y4XI@57723|Acidobacteria,2JJIM@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS2_k127_1708663_1	204669.Acid345_1305	1.557e-250	789.0	COG1009@1|root,COG1009@2|Bacteria,3Y2VS@57723|Acidobacteria,2JIG7@204432|Acidobacteriia	204432|Acidobacteriia	CP	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
TLS2_k127_1708663_3	204669.Acid345_1304	7.135e-229	717.0	COG1008@1|root,COG1008@2|Bacteria,3Y312@57723|Acidobacteria,2JITQ@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
TLS2_k127_1708663_5	204669.Acid345_1303	9.697e-172	554.0	COG1007@1|root,COG1007@2|Bacteria,3Y3PV@57723|Acidobacteria,2JIT3@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_1708663_8	1382359.JIAL01000001_gene2484	6.273e-77	271.0	COG1131@1|root,COG1131@2|Bacteria,3Y7J3@57723|Acidobacteria,2JMS8@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1708663_7	1163407.UU7_04737	1.769e-80	278.0	COG1834@1|root,COG1834@2|Bacteria,1MZ9U@1224|Proteobacteria,1RN0M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Amidinotransferase	-	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
TLS2_k127_1708663_12	1210884.HG799472_gene14912	1.88e-45	166.0	COG0607@1|root,COG0607@2|Bacteria,2IZWR@203682|Planctomycetes	203682|Planctomycetes	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_1719114_0	204669.Acid345_2291	3.777e-169	539.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,3Y47M@57723|Acidobacteria,2JKQK@204432|Acidobacteriia	204432|Acidobacteriia	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
TLS2_k127_1719114_3	1122221.JHVI01000014_gene1365	1.34e-34	138.0	COG0454@1|root,COG0456@2|Bacteria,1WK4D@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	FR47-like protein	-	-	2.3.1.82	ko:K18816	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1
TLS2_k127_1719114_1	204669.Acid345_2292	8.743e-121	395.0	COG0437@1|root,COG0437@2|Bacteria,3Y47T@57723|Acidobacteria,2JMIW@204432|Acidobacteriia	204432|Acidobacteriia	C	4Fe-4S dicluster domain	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11
TLS2_k127_1719114_2	204669.Acid345_2293	4.588e-53	199.0	COG3301@1|root,COG3301@2|Bacteria,3Y506@57723|Acidobacteria,2JN1H@204432|Acidobacteriia	204432|Acidobacteriia	P	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
TLS2_k127_1731080_8	204669.Acid345_0232	1.68e-05	47.0	COG0673@1|root,COG0673@2|Bacteria,3Y3ET@57723|Acidobacteria,2JHRR@204432|Acidobacteriia	204432|Acidobacteriia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_1731080_6	204669.Acid345_4555	2.677e-73	259.0	COG0810@1|root,COG0810@2|Bacteria,3Y3T5@57723|Acidobacteria,2JHKT@204432|Acidobacteriia	204432|Acidobacteriia	M	TonB C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_2,TonB_C
TLS2_k127_1731080_4	1380391.JIAS01000011_gene4720	1.132e-103	346.0	COG0596@1|root,COG0596@2|Bacteria,1QU30@1224|Proteobacteria,2TSNY@28211|Alphaproteobacteria,2JRIH@204441|Rhodospirillales	204441|Rhodospirillales	S	Serine aminopeptidase, S33	-	-	3.5.1.101	ko:K18457	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_1731080_7	1173022.Cri9333_4294	2.193e-66	241.0	COG1216@1|root,COG1216@2|Bacteria,1G3T8@1117|Cyanobacteria,1HA4H@1150|Oscillatoriales	1117|Cyanobacteria	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
TLS2_k127_1731080_5	682795.AciX8_1493	4.353e-77	278.0	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TLS2_k127_1731080_9	497964.CfE428DRAFT_4248	3.851e-05	56.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,46UMD@74201|Verrucomicrobia	2|Bacteria	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_10,TPR_11,TPR_16,TPR_2,TPR_8
TLS2_k127_1731080_0	682795.AciX8_1492	1.949e-185	606.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,3Y2V7@57723|Acidobacteria,2JIYH@204432|Acidobacteriia	57723|Acidobacteria	D	G-rich domain on putative tyrosine kinase	-	-	2.7.10.1	ko:K08252,ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,Wzz
TLS2_k127_1731080_2	326427.Cagg_1542	2.287e-135	437.0	COG0451@1|root,COG0451@2|Bacteria,2G7M6@200795|Chloroflexi	200795|Chloroflexi	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
TLS2_k127_1731080_1	926569.ANT_09960	1.188e-178	565.0	COG1089@1|root,COG1089@2|Bacteria,2G5P2@200795|Chloroflexi	200795|Chloroflexi	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_1731080_3	204669.Acid345_3823	2.849e-120	399.0	COG0438@1|root,COG0438@2|Bacteria,3Y5K5@57723|Acidobacteria,2JNE3@204432|Acidobacteriia	204432|Acidobacteriia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_173676_0	234267.Acid_3931	7.657e-250	796.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS2_k127_173676_2	204669.Acid345_1300	2.441e-09	58.0	COG0636@1|root,COG0636@2|Bacteria,3Y5G6@57723|Acidobacteria,2JJZ6@204432|Acidobacteriia	204432|Acidobacteriia	P	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
TLS2_k127_173676_1	1267534.KB906756_gene533	1.682e-21	96.0	COG0356@1|root,COG0356@2|Bacteria,3Y4CM@57723|Acidobacteria,2JJ5W@204432|Acidobacteriia	204432|Acidobacteriia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
TLS2_k127_175814_0	118163.Ple7327_1377	4.91e-90	300.0	COG1208@1|root,COG1208@2|Bacteria,1G00Y@1117|Cyanobacteria,3VIEN@52604|Pleurocapsales	1117|Cyanobacteria	JM	COGs COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon)	-	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
TLS2_k127_175814_2	118163.Ple7327_1371	1.281e-62	231.0	COG2120@1|root,COG2120@2|Bacteria,1G5JP@1117|Cyanobacteria,3VJMI@52604|Pleurocapsales	1117|Cyanobacteria	S	PFAM GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_175814_1	111780.Sta7437_1256	6.996e-84	293.0	COG0438@1|root,COG0438@2|Bacteria,1G3JN@1117|Cyanobacteria,3VM6P@52604|Pleurocapsales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_175814_3	926550.CLDAP_15290	3.432e-19	89.0	COG0451@1|root,COG0451@2|Bacteria,2G7TT@200795|Chloroflexi	200795|Chloroflexi	M	Male sterility protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_1758262_0	204669.Acid345_0770	4.733e-243	769.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_16,TPR_2,TPR_8
TLS2_k127_1758262_12	204669.Acid345_0088	1.166e-22	102.0	COG0328@1|root,COG0328@2|Bacteria,3Y4EY@57723|Acidobacteria,2JJ1U@204432|Acidobacteriia	204432|Acidobacteriia	L	Reverse transcriptase-like	-	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
TLS2_k127_1758262_8	1124780.ANNU01000023_gene3139	1.906e-57	203.0	COG0590@1|root,COG0590@2|Bacteria,4NNMU@976|Bacteroidetes,47PPK@768503|Cytophagia	976|Bacteroidetes	FJ	MafB19-like deaminase	guaD	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	MafB19-deam,dCMP_cyt_deam_1
TLS2_k127_1758262_7	491952.Mar181_1940	4.762e-74	265.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,1RQCM@1236|Gammaproteobacteria,1XITI@135619|Oceanospirillales	135619|Oceanospirillales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_1758262_11	643473.KB235930_gene978	8.191e-31	134.0	COG3221@1|root,COG3221@2|Bacteria,1G2Q9@1117|Cyanobacteria,1HIGE@1161|Nostocales	1117|Cyanobacteria	P	TIGRFAM phosphate phosphite phosphonate ABC transporters, periplasmic binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
TLS2_k127_1758262_10	1307761.L21SP2_1483	7.67e-37	149.0	COG3638@1|root,COG3638@2|Bacteria,2J6UW@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
TLS2_k127_1758262_9	118173.KB235914_gene3766	2.32e-47	182.0	COG3639@1|root,COG3639@2|Bacteria,1G2C0@1117|Cyanobacteria,1HHHB@1150|Oscillatoriales	1117|Cyanobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
TLS2_k127_1758262_13	1267534.KB906754_gene2958	1.248e-16	94.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K07000	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,BAAT_C,DUF676,Hydrolase_4
TLS2_k127_1758262_1	234267.Acid_7659	3.146e-200	634.0	COG0044@1|root,COG0044@2|Bacteria,3Y48H@57723|Acidobacteria	57723|Acidobacteria	F	PFAM amidohydrolase	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
TLS2_k127_1758262_6	485913.Krac_11396	5.517e-122	402.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_1758262_2	234267.Acid_7658	1.767e-193	616.0	COG1953@1|root,COG1953@2|Bacteria,3Y2FU@57723|Acidobacteria	57723|Acidobacteria	FH	PFAM Permease for cytosine purines, uracil, thiamine, allantoin	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
TLS2_k127_1758262_4	1340493.JNIF01000003_gene2936	1.714e-153	499.0	COG1012@1|root,COG1012@2|Bacteria,3Y3V5@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.28	ko:K00141,ko:K22187	ko00040,ko00622,ko00623,ko00627,ko01100,ko01120,ko01220,map00040,map00622,map00623,map00627,map01100,map01120,map01220	M00537,M00538	R01293,R01419,R05289,R05663,R05664,R07667,R11768	RC00075,RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_1758262_3	234267.Acid_7662	7.562e-176	561.0	COG0160@1|root,COG0160@2|Bacteria,3Y4EV@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.55	ko:K00823,ko:K15372	ko00250,ko00410,ko00430,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00430,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R01684	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_1758262_5	1396141.BATP01000059_gene2564	4.168e-146	468.0	COG0388@1|root,COG0388@2|Bacteria,46S7B@74201|Verrucomicrobia,2ITNA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Carbon-nitrogen hydrolase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
TLS2_k127_1768700_1	204669.Acid345_4664	6.548e-150	486.0	COG2234@1|root,COG2234@2|Bacteria,3Y43U@57723|Acidobacteria,2JIUZ@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_1768700_4	204669.Acid345_4665	3.108e-70	247.0	COG0705@1|root,COG0705@2|Bacteria,3Y45U@57723|Acidobacteria,2JIJ4@204432|Acidobacteriia	204432|Acidobacteriia	S	(Rhomboid) family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS2_k127_1768700_5	649638.Trad_2164	8.556e-50	181.0	COG2426@1|root,COG2426@2|Bacteria	2|Bacteria	S	small multidrug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
TLS2_k127_1768700_0	1382359.JIAL01000001_gene815	3.771e-177	569.0	COG0469@1|root,COG0469@2|Bacteria,3Y36V@57723|Acidobacteria,2JHY5@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
TLS2_k127_1768700_2	204669.Acid345_4670	1.685e-92	312.0	COG1295@1|root,COG1295@2|Bacteria,3Y4P8@57723|Acidobacteria,2JJBZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_1768700_7	32049.SYNPCC7002_A0731	2.126e-06	54.0	2E789@1|root,33DKF@2|Bacteria,1GAIS@1117|Cyanobacteria,1H1SK@1129|Synechococcus	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1768700_3	880072.Desac_1135	2.199e-73	265.0	COG0627@1|root,COG0627@2|Bacteria,1QIRQ@1224|Proteobacteria,43CPB@68525|delta/epsilon subdivisions,2X7WP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
TLS2_k127_1768700_6	204669.Acid345_4675	2.944e-36	138.0	COG0086@1|root,COG0086@2|Bacteria,3Y2FZ@57723|Acidobacteria,2JIW0@204432|Acidobacteriia	204432|Acidobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
TLS2_k127_1789413_5	204669.Acid345_0969	8.574e-76	272.0	2C89V@1|root,34AEG@2|Bacteria,3Y8IH@57723|Acidobacteria,2JNND@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1789413_8	204669.Acid345_4181	2.437e-10	73.0	COG3511@1|root,COG3511@2|Bacteria,3Y7AQ@57723|Acidobacteria,2JM7S@204432|Acidobacteriia	204432|Acidobacteriia	M	Phosphoesterase family	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
TLS2_k127_1789413_3	204669.Acid345_1460	6.028e-132	437.0	COG4254@1|root,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,FecR,LysM,fn3
TLS2_k127_1789413_1	204669.Acid345_1461	3.333e-209	654.0	COG1077@1|root,COG1077@2|Bacteria,3Y3VC@57723|Acidobacteria,2JHQ2@204432|Acidobacteriia	204432|Acidobacteriia	D	cell shape determining protein MreB	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TLS2_k127_1789413_4	204669.Acid345_1462	2.506e-87	302.0	COG1792@1|root,COG1792@2|Bacteria,3Y3CK@57723|Acidobacteria,2JIBI@204432|Acidobacteriia	204432|Acidobacteriia	M	Rod shape-determining protein MreC	-	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
TLS2_k127_1789413_6	204669.Acid345_1463	7.225e-55	203.0	2CM1I@1|root,32SDF@2|Bacteria,3Y571@57723|Acidobacteria,2JJRW@204432|Acidobacteriia	204432|Acidobacteriia	S	shape-determining protein MreD	-	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
TLS2_k127_1789413_0	1267533.KB906733_gene3089	1.297e-213	684.0	COG0768@1|root,COG0768@2|Bacteria,3Y3MX@57723|Acidobacteria,2JHRD@204432|Acidobacteriia	204432|Acidobacteriia	M	Penicillin-binding protein, dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
TLS2_k127_1789413_2	204669.Acid345_1466	2.609e-156	500.0	COG0772@1|root,COG0772@2|Bacteria,3Y3DZ@57723|Acidobacteria,2JINX@204432|Acidobacteriia	204432|Acidobacteriia	M	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
TLS2_k127_1789413_7	1382359.JIAL01000001_gene796	6.1e-43	175.0	COG1530@1|root,COG1530@2|Bacteria,3Y40K@57723|Acidobacteria,2JHQU@204432|Acidobacteriia	204432|Acidobacteriia	J	PFAM RNA-binding protein AU-1 Ribonuclease E G	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
TLS2_k127_1815159_8	313612.L8106_05311	1.226e-35	147.0	COG0745@1|root,COG2114@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG5002@2|Bacteria,1GHFQ@1117|Cyanobacteria,1HHU4@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	7TMR-DISM_7TM,Guanylate_cyc,HAMP,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg,dCache_1
TLS2_k127_1815159_4	278963.ATWD01000001_gene2178	3.282e-128	426.0	COG2204@1|root,COG2204@2|Bacteria,3Y41F@57723|Acidobacteria,2JIZR@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_1815159_12	1382359.JIAL01000001_gene985	9.698e-17	95.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria,2JI38@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TLS2_k127_1815159_13	1306174.JODP01000027_gene112	2.138e-09	71.0	COG2199@1|root,COG2202@1|root,COG2203@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	ppsR	-	2.1.1.80,2.7.13.3,2.7.7.65,3.1.1.61	ko:K03406,ko:K10125,ko:K13924,ko:K21084	ko02020,ko02026,ko02030,map02020,map02026,map02030	M00504,M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	GAF,GAF_2,GGDEF,HATPase_c,HTH_8,HisKA,HisKA_3,MASE1,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
TLS2_k127_1815159_2	1382359.JIAL01000001_gene1914	3.167e-162	517.0	COG1088@1|root,COG1088@2|Bacteria,3Y3E7@57723|Acidobacteria,2JIRI@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_1815159_3	240015.ACP_1869	1.307e-132	439.0	COG1209@1|root,COG1209@2|Bacteria,3Y2ZJ@57723|Acidobacteria,2JIYE@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_1815159_7	1173028.ANKO01000018_gene1179	1.323e-71	256.0	COG1898@1|root,COG1898@2|Bacteria,1G0QA@1117|Cyanobacteria,1H6ZK@1150|Oscillatoriales	1117|Cyanobacteria	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	rfbC	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
TLS2_k127_1815159_6	98439.AJLL01000028_gene4270	1.977e-95	320.0	COG1091@1|root,COG1091@2|Bacteria,1G1CP@1117|Cyanobacteria,1JK46@1189|Stigonemataceae	1117|Cyanobacteria	M	RmlD substrate binding domain	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.rfbD	RmlD_sub_bind
TLS2_k127_1815159_10	1382359.JIAL01000001_gene920	2.619e-18	100.0	2E6X5@1|root,331GM@2|Bacteria,3Y5N8@57723|Acidobacteria,2JJY7@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1815159_5	1382359.JIAL01000001_gene2437	4.795e-125	429.0	COG0760@1|root,COG0760@2|Bacteria,3Y3BW@57723|Acidobacteria,2JIP1@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,Rotamase_3,SurA_N_3
TLS2_k127_1815159_1	1267534.KB906756_gene224	2.6e-187	599.0	COG1640@1|root,COG1640@2|Bacteria,3Y392@57723|Acidobacteria,2JI7J@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM glycoside hydrolase family 77	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
TLS2_k127_1815159_0	204669.Acid345_2763	0.0	1163.0	COG3280@1|root,COG3280@2|Bacteria,3Y2QG@57723|Acidobacteria,2JIFT@204432|Acidobacteriia	204432|Acidobacteriia	G	TIGRFAM Malto-oligosyltrehalose synthase	-	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
TLS2_k127_1815159_11	234267.Acid_5579	8.23e-18	91.0	COG5592@1|root,COG5592@2|Bacteria	2|Bacteria	I	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin,Phasin_2
TLS2_k127_1815159_9	234267.Acid_4507	3.919e-27	116.0	COG0366@1|root,COG0366@2|Bacteria,3Y2P1@57723|Acidobacteria	57723|Acidobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
TLS2_k127_1894370_10	330214.NIDE3178	1.348e-19	94.0	COG0464@1|root,COG0464@2|Bacteria	2|Bacteria	O	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA
TLS2_k127_1894370_7	1267533.KB906733_gene3063	8.308e-26	108.0	COG0268@1|root,COG0268@2|Bacteria,3Y5CZ@57723|Acidobacteria,2JJS9@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
TLS2_k127_1894370_3	926566.Terro_0626	2.498e-84	289.0	COG2859@1|root,COG2859@2|Bacteria,3Y6DJ@57723|Acidobacteria,2JKFE@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09797	-	-	-	-	ko00000	-	-	-	SIMPL
TLS2_k127_1894370_0	204669.Acid345_2356	7.22e-185	585.0	COG1466@1|root,COG1466@2|Bacteria,3Y2XE@57723|Acidobacteria,2JI6X@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
TLS2_k127_1894370_6	204669.Acid345_2357	1.276e-49	186.0	COG2980@1|root,COG2980@2|Bacteria,3Y4V4@57723|Acidobacteria,2JJKB@204432|Acidobacteriia	204432|Acidobacteriia	M	Lipopolysaccharide-assembly	-	-	-	-	-	-	-	-	-	-	-	-	LptE
TLS2_k127_1894370_1	204669.Acid345_2358	4.087e-109	366.0	COG0136@1|root,COG0136@2|Bacteria,3Y395@57723|Acidobacteria,2JI31@204432|Acidobacteriia	204432|Acidobacteriia	E	Semialdehyde dehydrogenase	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_1894370_2	204669.Acid345_2359	2.527e-99	333.0	COG1183@1|root,COG1183@2|Bacteria,3Y3I7@57723|Acidobacteria,2JIEG@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_1894370_4	240015.ACP_1018	3.889e-73	252.0	COG0688@1|root,COG0688@2|Bacteria,3Y4AZ@57723|Acidobacteria,2JJ6I@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
TLS2_k127_1894370_8	204669.Acid345_2361	6.394e-25	106.0	2ETRB@1|root,33M8W@2|Bacteria,3Y5ZS@57723|Acidobacteria,2JNW9@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF465)	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
TLS2_k127_1894370_9	204669.Acid345_2362	5.723e-20	103.0	COG0454@1|root,COG0456@2|Bacteria,3Y5KS@57723|Acidobacteria,2JJY0@204432|Acidobacteriia	204432|Acidobacteriia	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TLS2_k127_1894370_5	479434.Sthe_2325	3.692e-72	251.0	COG0451@1|root,COG0451@2|Bacteria,2G9SG@200795|Chloroflexi	200795|Chloroflexi	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_190203_7	518766.Rmar_1802	2.735e-44	183.0	COG1834@1|root,COG1834@2|Bacteria,4PECN@976|Bacteroidetes,1FIVN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
TLS2_k127_190203_5	1242864.D187_006580	3.093e-52	211.0	COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,42RD4@68525|delta/epsilon subdivisions,2WN11@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_190203_2	204669.Acid345_2780	2.519e-126	421.0	COG1820@1|root,COG1820@2|Bacteria,3Y3NQ@57723|Acidobacteria,2JIST@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS2_k127_190203_3	1340493.JNIF01000003_gene2606	1.195e-94	326.0	COG0449@1|root,COG0449@2|Bacteria,3Y2NE@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
TLS2_k127_190203_1	204669.Acid345_3293	3.779e-182	576.0	COG0665@1|root,COG0665@2|Bacteria,3Y5BS@57723|Acidobacteria,2JK99@204432|Acidobacteriia	204432|Acidobacteriia	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303,ko:K21061	ko00260,ko00330,ko01100,map00260,map00330,map01100	-	R00610,R11428	RC00060,RC00135,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
TLS2_k127_190203_11	1178482.BJB45_04235	1.911e-20	104.0	28IX1@1|root,2Z8V3@2|Bacteria,1N0WD@1224|Proteobacteria,1RSH6@1236|Gammaproteobacteria,1XP8A@135619|Oceanospirillales	135619|Oceanospirillales	S	Protein of unknown function (DUF2914)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2914
TLS2_k127_190203_8	204669.Acid345_3129	1.995e-40	149.0	2CE7D@1|root,32RZ9@2|Bacteria,3Y55E@57723|Acidobacteria,2JJQR@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_190203_0	204669.Acid345_3140	3.684e-184	586.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,3Y339@57723|Acidobacteria,2JIM0@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
TLS2_k127_190203_9	204669.Acid345_1320	9.722e-40	149.0	2EEBU@1|root,33864@2|Bacteria,3Y5SH@57723|Acidobacteria,2JK0E@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_190203_6	204669.Acid345_1319	3.694e-47	174.0	COG0789@1|root,COG0789@2|Bacteria,3Y5EZ@57723|Acidobacteria,2JN9T@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_190203_12	204669.Acid345_1317	8.993e-20	90.0	COG2104@1|root,COG2104@2|Bacteria,3Y5XU@57723|Acidobacteria,2JK4P@204432|Acidobacteriia	204432|Acidobacteriia	H	thiamine biosynthesis protein ThiS	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS2_k127_190203_10	983544.Lacal_2171	4.69e-29	124.0	COG3797@1|root,COG3797@2|Bacteria,4NSKS@976|Bacteroidetes,1I70K@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
TLS2_k127_190203_4	278963.ATWD01000001_gene1278	3.01e-67	247.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
TLS2_k127_19435_0	682795.AciX8_1478	1.291e-83	299.0	COG1086@1|root,COG1086@2|Bacteria,3Y3IK@57723|Acidobacteria,2JK0U@204432|Acidobacteriia	204432|Acidobacteriia	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
TLS2_k127_19435_2	1174528.JH992898_gene1126	2.363e-23	103.0	2DRDY@1|root,33BC0@2|Bacteria,1G9R7@1117|Cyanobacteria,1JMI1@1189|Stigonemataceae	1117|Cyanobacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
TLS2_k127_19435_3	1337936.IJ00_06515	1.485e-13	76.0	2DQ7S@1|root,3355J@2|Bacteria,1GA7T@1117|Cyanobacteria,1HPJ8@1161|Nostocales	1117|Cyanobacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core3
TLS2_k127_19435_1	446469.Sked_21530	1.893e-42	166.0	COG1131@1|root,COG1131@2|Bacteria,2GTNE@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_19435_4	272557.APE_2512	0.0005459	51.0	COG0842@1|root,arCOG01465@2157|Archaea,2XQB0@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_1954176_1	204669.Acid345_4514	1.611e-57	209.0	COG2121@1|root,COG2121@2|Bacteria,3Y4VJ@57723|Acidobacteria,2JJE4@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
TLS2_k127_1954176_0	204669.Acid345_4513	5.961e-73	252.0	COG1668@1|root,COG1668@2|Bacteria,3Y2XV@57723|Acidobacteria,2JIQK@204432|Acidobacteriia	204432|Acidobacteriia	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_1972507_0	682795.AciX8_1330	0.0	1693.0	COG0458@1|root,COG0458@2|Bacteria,3Y3GG@57723|Acidobacteria,2JIJZ@204432|Acidobacteriia	204432|Acidobacteriia	F	TIGRFAM carbamoyl-phosphate synthase, large subunit	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS2_k127_1985468_6	1535422.ND16A_1887	6.856e-188	592.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,1RQ1A@1236|Gammaproteobacteria,2Q6Q9@267889|Colwelliaceae	1236|Gammaproteobacteria	M	PFAM membrane bound O-acyl transferase MBOAT family protein	patA	-	-	-	-	-	-	-	-	-	-	-	MBOAT
TLS2_k127_1985468_23	234267.Acid_7877	1.603e-49	183.0	COG1376@1|root,COG1376@2|Bacteria,3Y7TU@57723|Acidobacteria	57723|Acidobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS2_k127_1985468_9	204669.Acid345_1730	1.989e-133	439.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_1985468_24	204669.Acid345_1731	8.028e-46	183.0	2FAIU@1|root,342SV@2|Bacteria,3Y86W@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1985468_22	234267.Acid_7875	1.033e-51	200.0	COG0747@1|root,COG0747@2|Bacteria,3Y86U@57723|Acidobacteria	57723|Acidobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
TLS2_k127_1985468_8	234267.Acid_7874	1.573e-149	499.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_1985468_5	204669.Acid345_1734	4.135e-201	640.0	COG2204@1|root,COG2204@2|Bacteria,3Y2J1@57723|Acidobacteria,2JIIE@204432|Acidobacteriia	57723|Acidobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_1985468_31	395019.Bmul_4949	1.943e-06	49.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VIFS@28216|Betaproteobacteria,1K04V@119060|Burkholderiaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_1985468_10	446470.Snas_2965	1.593e-127	447.0	COG2133@1|root,COG3291@1|root,COG3506@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG3506@2|Bacteria	2|Bacteria	M	Protein of unknown function (DUF1349)	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	DUF1349,GSDH,Ig_3,LGFP,PA14,PKD,fn3
TLS2_k127_1985468_16	521098.Aaci_0272	1.533e-80	292.0	COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,4HB15@91061|Bacilli,27AQE@186823|Alicyclobacillaceae	91061|Bacilli	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS2_k127_1985468_12	414684.RC1_2537	1.486e-119	399.0	COG0438@1|root,COG0438@2|Bacteria,1MVA7@1224|Proteobacteria,2U0DX@28211|Alphaproteobacteria,2JV97@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_1985468_27	1210884.HG799463_gene9897	1.514e-26	121.0	COG0500@1|root,COG2226@2|Bacteria,2J51A@203682|Planctomycetes	203682|Planctomycetes	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS2_k127_1985468_29	443254.Marpi_1245	2.436e-15	89.0	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	ko:K02847	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	TPR_8,Wzy_C
TLS2_k127_1985468_15	1198114.AciX9_0586	1.109e-82	293.0	COG3206@1|root,COG3206@2|Bacteria,3Y2PJ@57723|Acidobacteria,2JHP9@204432|Acidobacteriia	204432|Acidobacteriia	M	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzz
TLS2_k127_1985468_11	682795.AciX8_1720	1.4e-122	426.0	COG3170@1|root,COG3170@2|Bacteria,3Y3SW@57723|Acidobacteria,2JIDZ@204432|Acidobacteriia	204432|Acidobacteriia	NU	Capsule assembly protein Wzi	-	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi
TLS2_k127_1985468_4	204669.Acid345_0888	2.655e-229	748.0	COG1596@1|root,COG1596@2|Bacteria,3Y457@57723|Acidobacteria,2JIBJ@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Polysaccharide export protein	-	-	-	-	-	-	-	-	-	-	-	-	Poly_export,SLBB
TLS2_k127_1985468_26	1267534.KB906755_gene4130	2.29e-37	149.0	COG0250@1|root,COG0250@2|Bacteria	2|Bacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601,ko:K05785	-	-	-	-	ko00000,ko03000,ko03009,ko03021	-	-	-	KOW,NusG
TLS2_k127_1985468_1	204669.Acid345_3426	1.92e-291	906.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,3Y3YD@57723|Acidobacteria,2JIG8@204432|Acidobacteriia	204432|Acidobacteriia	E	homocysteine S-methyltransferase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
TLS2_k127_1985468_17	204669.Acid345_3311	5.413e-74	262.0	COG1596@1|root,COG1596@2|Bacteria,3Y57H@57723|Acidobacteria,2JJNS@204432|Acidobacteriia	57723|Acidobacteria	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
TLS2_k127_1985468_19	1267533.KB906737_gene1516	2.683e-69	245.0	COG1596@1|root,COG1596@2|Bacteria,3Y57H@57723|Acidobacteria,2JJNS@204432|Acidobacteriia	204432|Acidobacteriia	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
TLS2_k127_1985468_7	1382359.JIAL01000001_gene110	2.107e-184	590.0	COG0260@1|root,COG0260@2|Bacteria,3Y33T@57723|Acidobacteria,2JHUM@204432|Acidobacteriia	204432|Acidobacteriia	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS2_k127_1985468_20	204669.Acid345_1996	5.431e-69	237.0	COG0691@1|root,COG0691@2|Bacteria,3Y4CC@57723|Acidobacteria,2JJ48@204432|Acidobacteriia	204432|Acidobacteriia	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
TLS2_k127_1985468_3	204669.Acid345_1997	1.42e-254	807.0	COG0457@1|root,COG4796@1|root,COG0457@2|Bacteria,COG4796@2|Bacteria,3Y2G2@57723|Acidobacteria,2JHZH@204432|Acidobacteriia	204432|Acidobacteriia	U	Belongs to the GSP D family	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Cohesin,Secretin,Secretin_N
TLS2_k127_1985468_13	379066.GAU_2793	2.663e-102	344.0	COG2321@1|root,COG2321@2|Bacteria,1ZSN1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
TLS2_k127_1985468_21	639030.JHVA01000001_gene638	5.68e-65	228.0	COG2165@1|root,COG2165@2|Bacteria,3Y4RJ@57723|Acidobacteria,2JJB4@204432|Acidobacteriia	204432|Acidobacteriia	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
TLS2_k127_1985468_25	1382359.JIAL01000001_gene2214	2.598e-41	157.0	COG2165@1|root,COG2165@2|Bacteria,3Y4ZX@57723|Acidobacteria,2JJN5@204432|Acidobacteriia	204432|Acidobacteriia	U	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
TLS2_k127_1985468_2	204669.Acid345_2032	1.339e-282	881.0	COG0018@1|root,COG0018@2|Bacteria,3Y35R@57723|Acidobacteria,2JIAM@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
TLS2_k127_1985468_0	204669.Acid345_2030	1.976e-321	995.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,3Y2I2@57723|Acidobacteria,2JIC5@204432|Acidobacteriia	204432|Acidobacteriia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
TLS2_k127_1985468_14	204669.Acid345_2029	2.916e-98	327.0	COG0084@1|root,COG0084@2|Bacteria,3Y4DK@57723|Acidobacteria,2JJ1I@204432|Acidobacteriia	204432|Acidobacteriia	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
TLS2_k127_1985468_18	1382359.JIAL01000001_gene117	3.641e-70	241.0	COG1666@1|root,COG1666@2|Bacteria,3Y4I3@57723|Acidobacteria,2JJ8P@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the UPF0234 family	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
TLS2_k127_1985468_28	204669.Acid345_2027	6.82e-22	96.0	COG0142@1|root,COG0142@2|Bacteria,3Y2VJ@57723|Acidobacteria,2JHS0@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_1989014_14	1144275.COCOR_03147	7.066e-05	46.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,4360M@68525|delta/epsilon subdivisions,2X2HZ@28221|Deltaproteobacteria,2Z0WC@29|Myxococcales	28221|Deltaproteobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_1989014_10	1122169.AREN01000054_gene2404	5.622e-33	137.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	ubiE_2	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31
TLS2_k127_1989014_8	1229276.DI53_2016	5.965e-100	339.0	COG0626@1|root,COG0626@2|Bacteria,4NF0Q@976|Bacteroidetes	976|Bacteroidetes	E	cystathionine	-	-	4.4.1.1	ko:K01758	ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230	M00338	R00782,R01001,R02408,R04770,R04930,R09366	RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
TLS2_k127_1989014_4	1121022.ABENE_05270	4.087e-132	431.0	COG1680@1|root,COG1680@2|Bacteria,1NHIY@1224|Proteobacteria,2U0A3@28211|Alphaproteobacteria,2KICB@204458|Caulobacterales	204458|Caulobacterales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_1989014_6	1123278.KB893444_gene1724	5.63e-119	397.0	COG0312@1|root,COG0312@2|Bacteria,4NE1F@976|Bacteroidetes,47MJJ@768503|Cytophagia	976|Bacteroidetes	S	Peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS2_k127_1989014_0	234267.Acid_5973	1.632e-187	601.0	COG0312@1|root,COG0312@2|Bacteria,3Y6TF@57723|Acidobacteria	57723|Acidobacteria	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS2_k127_1989014_7	204669.Acid345_3358	9.859e-102	334.0	COG0377@1|root,COG0377@2|Bacteria,3Y3JS@57723|Acidobacteria,2JM3C@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TLS2_k127_1989014_12	240015.ACP_0722	3.534e-31	126.0	COG2146@1|root,COG2146@2|Bacteria,3Y5NP@57723|Acidobacteria,2JJY6@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM Rieske 2Fe-2S	-	-	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
TLS2_k127_1989014_1	204669.Acid345_2866	8.218e-152	490.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,3Y52R@57723|Acidobacteria	57723|Acidobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1989014_9	204669.Acid345_3328	1.341e-99	330.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	yjcH1	-	3.8.1.2	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	DUF3667,HAD_2
TLS2_k127_1989014_2	204669.Acid345_3656	2.778e-149	483.0	COG3191@1|root,COG3191@2|Bacteria	2|Bacteria	EQ	aminopeptidase activity	dmpA	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
TLS2_k127_1989014_3	204669.Acid345_3445	1.113e-133	430.0	COG2107@1|root,COG2107@2|Bacteria,3Y31U@57723|Acidobacteria,2JIDE@204432|Acidobacteriia	204432|Acidobacteriia	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
TLS2_k127_1989014_11	204669.Acid345_3444	3.31e-32	132.0	COG1268@1|root,COG1268@2|Bacteria,3Y5K4@57723|Acidobacteria,2JJWF@204432|Acidobacteriia	204432|Acidobacteriia	S	BioY family	-	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
TLS2_k127_1989014_5	204669.Acid345_3224	1.7e-120	398.0	COG0006@1|root,COG0006@2|Bacteria,3Y36W@57723|Acidobacteria,2JI54@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the peptidase M24B family	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
TLS2_k127_2013889_2	204669.Acid345_1212	7.143e-20	92.0	COG1250@1|root,COG1250@2|Bacteria,3Y3S5@57723|Acidobacteria,2JI6S@204432|Acidobacteriia	57723|Acidobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_2013889_4	1382359.JIAL01000001_gene1921	7.475e-05	49.0	COG1629@1|root,COG4771@2|Bacteria,3Y7DM@57723|Acidobacteria,2JMEV@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_2013889_0	997346.HMPREF9374_0789	7.93e-144	467.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,27BB2@186824|Thermoactinomycetaceae	91061|Bacilli	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_2013889_1	204669.Acid345_3067	3.555e-47	171.0	COG3118@1|root,COG3118@2|Bacteria,3Y53D@57723|Acidobacteria,2JJHK@204432|Acidobacteriia	204432|Acidobacteriia	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS2_k127_2013889_3	1300345.LF41_1134	7.142e-14	76.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS2_k127_2042677_21	661478.OP10G_3369	1.341e-36	143.0	2E3B3@1|root,32XJU@2|Bacteria	2|Bacteria	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
TLS2_k127_2042677_13	639030.JHVA01000001_gene761	9.608e-83	280.0	COG1321@1|root,COG1321@2|Bacteria,3Y6Q1@57723|Acidobacteria,2JMID@204432|Acidobacteriia	204432|Acidobacteriia	K	FeoA	-	-	-	-	-	-	-	-	-	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
TLS2_k127_2042677_0	682795.AciX8_4469	0.0	1233.0	COG1048@1|root,COG1048@2|Bacteria,3Y34Q@57723|Acidobacteria,2JHMV@204432|Acidobacteriia	204432|Acidobacteriia	C	aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS2_k127_2042677_12	204669.Acid345_4783	5.651e-101	339.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Rhodanese,Thioredoxin_8
TLS2_k127_2042677_16	234267.Acid_7686	1.105e-63	239.0	2F2X8@1|root,33VSU@2|Bacteria,3Y7XB@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2042677_11	234267.Acid_7687	3.162e-127	420.0	COG1131@1|root,COG1131@2|Bacteria,3Y4YH@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_2042677_17	1340493.JNIF01000003_gene1503	4.224e-54	202.0	COG1277@1|root,COG1277@2|Bacteria,3Y839@57723|Acidobacteria	57723|Acidobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_2042677_10	234267.Acid_7689	5.905e-136	445.0	COG1131@1|root,COG1131@2|Bacteria,3Y6U6@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_2042677_1	1267534.KB906759_gene1816	1.372e-177	590.0	COG3712@1|root,COG3712@2|Bacteria,3Y772@57723|Acidobacteria	57723|Acidobacteria	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
TLS2_k127_2042677_20	234267.Acid_7691	4.385e-37	147.0	COG1595@1|root,COG1595@2|Bacteria,3Y8Q7@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2042677_7	414996.IL38_07585	1.983e-153	497.0	COG3211@1|root,COG3211@2|Bacteria,2GJKE@201174|Actinobacteria,409RH@622450|Actinopolysporales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF839)	-	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
TLS2_k127_2042677_9	518766.Rmar_2384	1.056e-141	467.0	COG0591@1|root,COG0591@2|Bacteria,4NEN8@976|Bacteroidetes	976|Bacteroidetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_2042677_15	1267533.KB906734_gene3730	7.076e-65	230.0	2AYX9@1|root,31R2Z@2|Bacteria,3Y4ZH@57723|Acidobacteria,2JJGK@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_2042677_23	1206725.BAFU01000058_gene791	1.973e-09	65.0	COG0375@1|root,COG0375@2|Bacteria,2IMJK@201174|Actinobacteria,4G2AZ@85025|Nocardiaceae	201174|Actinobacteria	S	Hydrogenase/urease nickel incorporation, metallochaperone, hypA	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
TLS2_k127_2042677_6	357808.RoseRS_1722	2.036e-160	522.0	COG0334@1|root,COG0334@2|Bacteria,2G5SR@200795|Chloroflexi,376F1@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS2_k127_2042677_14	392500.Swoo_1375	5.751e-74	263.0	COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,1RSGM@1236|Gammaproteobacteria,2QEHK@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
TLS2_k127_2042677_4	234267.Acid_0850	3.1e-169	549.0	COG0389@1|root,COG0389@2|Bacteria,3Y3NY@57723|Acidobacteria	57723|Acidobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
TLS2_k127_2042677_19	1267535.KB906767_gene1012	1.464e-50	182.0	COG2947@1|root,COG2947@2|Bacteria,3Y54W@57723|Acidobacteria,2JJUK@204432|Acidobacteriia	204432|Acidobacteriia	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
TLS2_k127_2042677_3	204669.Acid345_4630	2.94e-171	551.0	COG0577@1|root,COG0577@2|Bacteria,3Y2IG@57723|Acidobacteria,2JHUY@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_2042677_2	204669.Acid345_4631	1.804e-174	558.0	COG0577@1|root,COG0577@2|Bacteria,3Y3X9@57723|Acidobacteria,2JHKJ@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_2042677_5	204669.Acid345_0539	4.653e-165	541.0	COG1305@1|root,COG1305@2|Bacteria,3Y3A2@57723|Acidobacteria,2JHZ8@204432|Acidobacteriia	204432|Acidobacteriia	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
TLS2_k127_2042677_8	204669.Acid345_0540	1.022e-141	473.0	COG1305@1|root,COG1305@2|Bacteria,3Y2TK@57723|Acidobacteria,2JHX7@204432|Acidobacteriia	204432|Acidobacteriia	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
TLS2_k127_2042677_18	1122939.ATUD01000012_gene3154	8.921e-52	196.0	COG2085@1|root,COG2085@2|Bacteria,2ICZ0@201174|Actinobacteria	201174|Actinobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
TLS2_k127_2042677_22	565033.GACE_2059	3.42e-25	108.0	COG1060@1|root,arCOG00656@2157|Archaea,2XU6S@28890|Euryarchaeota,245QQ@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)	cofH	-	2.5.1.77	ko:K11781	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
TLS2_k127_2053396_0	1128421.JAGA01000004_gene2543	2.139e-209	680.0	COG1197@1|root,COG1197@2|Bacteria,2NNMM@2323|unclassified Bacteria	2|Bacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS2_k127_2093265_6	204669.Acid345_3454	1.483e-69	243.0	COG2930@1|root,COG2930@2|Bacteria,3Y2F0@57723|Acidobacteria,2JIT6@204432|Acidobacteriia	204432|Acidobacteriia	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
TLS2_k127_2093265_9	406124.ACPC01000019_gene2810	1.046e-10	63.0	2EFZF@1|root,339RM@2|Bacteria,1VMG6@1239|Firmicutes,4HR8G@91061|Bacilli,1ZK3J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2093265_3	1267535.KB906767_gene2921	5.156e-83	282.0	COG0664@1|root,COG0664@2|Bacteria,3Y69P@57723|Acidobacteria	57723|Acidobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_2093265_8	1198114.AciX9_1850	1.646e-36	147.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,KAP_NTPase,PAS_4,Response_reg,TIR_2,Trans_reg_C
TLS2_k127_2093265_4	1198114.AciX9_2562	1.2e-80	279.0	COG2204@1|root,COG2204@2|Bacteria,3Y3P6@57723|Acidobacteria,2JIHX@204432|Acidobacteriia	204432|Acidobacteriia	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_2093265_7	316055.RPE_3371	6.633e-46	173.0	COG0664@1|root,COG0664@2|Bacteria,1MV7G@1224|Proteobacteria,2U1I4@28211|Alphaproteobacteria,3JUCQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator, Crp Fnr family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_2093265_5	1198114.AciX9_2543	4.95e-80	274.0	COG0664@1|root,COG0664@2|Bacteria,3Y69I@57723|Acidobacteria,2JKT5@204432|Acidobacteriia	57723|Acidobacteria	K	SMART cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_2093265_0	204669.Acid345_0731	1.52e-116	389.0	COG3511@1|root,COG3511@2|Bacteria,3Y7AQ@57723|Acidobacteria,2JM7S@204432|Acidobacteriia	2|Bacteria	M	Phosphoesterase family	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
TLS2_k127_2093265_1	639030.JHVA01000001_gene1370	8.475e-102	340.0	COG0457@1|root,COG0457@2|Bacteria,3Y6HH@57723|Acidobacteria,2JNZ8@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2093265_2	1267534.KB906754_gene2869	2.48e-87	296.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	VP1287	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	LolA_like
TLS2_k127_2114330_2	234267.Acid_3087	0.000154	49.0	COG1629@1|root,COG1629@2|Bacteria,3Y2ZC@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_2114330_0	204669.Acid345_2288	3.306e-138	450.0	COG0436@1|root,COG0436@2|Bacteria,3Y2VQ@57723|Acidobacteria,2JI77@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS2_k127_2114330_1	240015.ACP_0422	4.128e-27	110.0	COG0491@1|root,COG0491@2|Bacteria,3Y4DN@57723|Acidobacteria,2JJ36@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_2123221_0	469383.Cwoe_3870	2.211e-215	689.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4CS94@84995|Rubrobacteria	201174|Actinobacteria	C	xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3,1.5.99.4	ko:K03520,ko:K19820	ko00760,ko01120,map00760,map01120	M00810	R02860,R07946,R11168	RC00589,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_2123221_4	272557.APE_2225.1	9.205e-25	108.0	COG3427@1|root,arCOG01927@2157|Archaea,2XRD9@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM carbon monoxide dehydrogenase subunit G	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
TLS2_k127_2123221_2	644966.Tmar_1491	4.108e-69	237.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia,3WDUM@538999|Clostridiales incertae sedis	186801|Clostridia	C	COGs COG2080 Aerobic-type carbon monoxide dehydrogenase small subunit CoxS CutS homologs	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_2123221_3	479434.Sthe_2778	1.948e-64	231.0	COG1319@1|root,COG1319@2|Bacteria,2G84Z@200795|Chloroflexi,27Z3G@189775|Thermomicrobia	189775|Thermomicrobia	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_2123221_1	679197.HMPREF9336_00544	1.012e-107	359.0	COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria	201174|Actinobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	fbiC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044464,GO:0044689,GO:0050896,GO:0051186,GO:0051188,GO:0051409,GO:0071944	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
TLS2_k127_2124716_0	1242864.D187_000828	8.982e-187	592.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,43BBS@68525|delta/epsilon subdivisions,2X6QY@28221|Deltaproteobacteria,2YU79@29|Myxococcales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS2_k127_2124716_3	204669.Acid345_4712	1.656e-67	236.0	COG2094@1|root,COG2094@2|Bacteria,3Y5DM@57723|Acidobacteria,2JMBB@204432|Acidobacteriia	204432|Acidobacteriia	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
TLS2_k127_2124716_4	1121920.AUAU01000006_gene301	9.962e-55	198.0	2BYAB@1|root,32R2Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2124716_2	204669.Acid345_4743	3.692e-104	346.0	COG0414@1|root,COG0414@2|Bacteria,3Y40A@57723|Acidobacteria,2JHS1@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
TLS2_k127_2124716_5	204669.Acid345_4744	9.128e-54	199.0	COG1409@1|root,COG1409@2|Bacteria,3Y91N@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS2_k127_2124716_1	204669.Acid345_4746	4.269e-134	434.0	COG0413@1|root,COG0413@2|Bacteria,3Y3GX@57723|Acidobacteria,2JI6Y@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TLS2_k127_2138367_27	1082931.KKY_2008	2.692e-12	75.0	2DQNQ@1|root,337TP@2|Bacteria,1NFYG@1224|Proteobacteria,2UFD8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2138367_7	1382359.JIAL01000001_gene350	4.095e-112	377.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	rip3	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	-	ko:K06212,ko:K06402	-	-	-	-	ko00000,ko01000,ko01002,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	CBS,Form_Nir_trans,Peptidase_M50,Peptidase_M50B
TLS2_k127_2138367_13	204669.Acid345_2162	5.804e-85	310.0	COG1462@1|root,COG1462@2|Bacteria,3Y3KF@57723|Acidobacteria	57723|Acidobacteria	M	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
TLS2_k127_2138367_26	195253.Syn6312_3496	9.499e-13	70.0	2C5EY@1|root,32YQJ@2|Bacteria,1GFQ4@1117|Cyanobacteria,1H3KH@1129|Synechococcus	1117|Cyanobacteria	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
TLS2_k127_2138367_0	1183438.GKIL_0310	1.488e-209	666.0	COG0433@1|root,COG0561@1|root,COG0433@2|Bacteria,COG0561@2|Bacteria,1G3GC@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF87,Hydrolase_3
TLS2_k127_2138367_20	237368.SCABRO_02565	1.508e-60	215.0	COG1238@1|root,COG1238@2|Bacteria,2J05B@203682|Planctomycetes	203682|Planctomycetes	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_2138367_30	523850.TON_0862	8.835e-05	48.0	COG1225@1|root,arCOG00310@2157|Archaea,2XY0E@28890|Euryarchaeota,2440M@183968|Thermococci	183968|Thermococci	O	SCO1/SenC	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_2138367_29	1379270.AUXF01000007_gene972	5.305e-06	53.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03386,ko:K03564,ko:K16922	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_2138367_12	1038859.AXAU01000015_gene932	3.805e-94	327.0	COG2159@1|root,COG2159@2|Bacteria,1Q4XY@1224|Proteobacteria,2U25S@28211|Alphaproteobacteria,3JUPG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_2138367_4	1267534.KB906755_gene4826	2.229e-148	476.0	COG1181@1|root,COG1181@2|Bacteria,3Y6Z0@57723|Acidobacteria,2JKPX@204432|Acidobacteriia	204432|Acidobacteriia	M	ATP-grasp domain	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
TLS2_k127_2138367_2	1267533.KB906738_gene2098	1.102e-155	498.0	COG4307@1|root,COG4307@2|Bacteria,3Y69G@57723|Acidobacteria,2JM0B@204432|Acidobacteriia	204432|Acidobacteriia	S	Putative zinc-binding metallo-peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx
TLS2_k127_2138367_14	1278073.MYSTI_05965	3.196e-79	272.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,42RCM@68525|delta/epsilon subdivisions,2WN89@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	response regulator	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
TLS2_k127_2138367_16	1254432.SCE1572_26545	6.991e-78	276.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,42R4U@68525|delta/epsilon subdivisions,2X799@28221|Deltaproteobacteria,2Z0T8@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
TLS2_k127_2138367_21	1232410.KI421428_gene1003	3.827e-58	220.0	COG2199@1|root,COG2199@2|Bacteria,1R80Z@1224|Proteobacteria,42RXX@68525|delta/epsilon subdivisions,2WNME@28221|Deltaproteobacteria,43TKF@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
TLS2_k127_2138367_18	204669.Acid345_4006	2.029e-70	253.0	COG1879@1|root,COG1879@2|Bacteria,3Y3UK@57723|Acidobacteria,2JHS2@204432|Acidobacteriia	204432|Acidobacteriia	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TLS2_k127_2138367_25	267377.MMP0997	3.786e-15	89.0	COG3794@1|root,arCOG02926@2157|Archaea,2Y7QT@28890|Euryarchaeota,23RRF@183939|Methanococci	183939|Methanococci	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
TLS2_k127_2138367_11	1120980.JQKH01000009_gene1403	3.293e-95	330.0	COG2010@1|root,COG2132@1|root,COG2010@2|Bacteria,COG2132@2|Bacteria,1MV74@1224|Proteobacteria,2VK95@28216|Betaproteobacteria,2KQR4@206351|Neisseriales	206351|Neisseriales	C	Multicopper oxidase	aniA	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_3,Cytochrom_C,Cytochrome_CBB3
TLS2_k127_2138367_17	204669.Acid345_0365	1.431e-73	256.0	COG2846@1|root,COG2846@2|Bacteria,3Y4SU@57723|Acidobacteria,2JMU3@204432|Acidobacteriia	204432|Acidobacteriia	D	Domain of Unknown function (DUF542)	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
TLS2_k127_2138367_15	204669.Acid345_0362	3.822e-79	271.0	COG0664@1|root,COG0664@2|Bacteria,3Y4WU@57723|Acidobacteria,2JMTC@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_2138367_6	1122223.KB890687_gene2492	8.875e-118	391.0	COG2133@1|root,COG2133@2|Bacteria,1WJQY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS2_k127_2138367_1	1121413.JMKT01000009_gene2122	6.813e-189	604.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2WJTI@28221|Deltaproteobacteria,2M9TB@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
TLS2_k127_2138367_5	1380394.JADL01000003_gene4837	2.1e-125	419.0	COG1816@1|root,COG1816@2|Bacteria,1R6Q8@1224|Proteobacteria,2U0BN@28211|Alphaproteobacteria,2JQP7@204441|Rhodospirillales	204441|Rhodospirillales	F	Adenosine/AMP deaminase	add	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
TLS2_k127_2138367_8	278963.ATWD01000001_gene2440	7.501e-111	376.0	COG1538@1|root,COG1538@2|Bacteria,3Y6KZ@57723|Acidobacteria,2JMBT@204432|Acidobacteriia	204432|Acidobacteriia	MU	Outer membrane efflux protein	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
TLS2_k127_2138367_3	1267535.KB906767_gene546	8.53e-151	491.0	COG2132@1|root,COG2132@2|Bacteria,3Y5PP@57723|Acidobacteria,2JK1U@204432|Acidobacteriia	204432|Acidobacteriia	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22348	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
TLS2_k127_2138367_19	1379698.RBG1_1C00001G0290	2.358e-68	260.0	COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria	2|Bacteria	E	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1,PD40,Peptidase_M1
TLS2_k127_2138367_24	204669.Acid345_2010	1.145e-45	173.0	COG3026@1|root,COG3026@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	DUF4412,FtsX,LolA_like,MucB_RseB,MucB_RseB_C,zf-HC2
TLS2_k127_2138367_23	485913.Krac_8761	1.795e-47	181.0	COG3483@1|root,COG3483@2|Bacteria,2G976@200795|Chloroflexi	200795|Chloroflexi	E	Tryptophan 2,3-dioxygenase	-	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
TLS2_k127_2138367_9	204669.Acid345_0970	2.171e-104	353.0	COG1136@1|root,COG1136@2|Bacteria,3Y3JD@57723|Acidobacteria,2JIHH@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_2138367_22	204669.Acid345_0967	2.029e-50	183.0	COG0784@1|root,COG0784@2|Bacteria,3Y4W5@57723|Acidobacteria,2JJGI@204432|Acidobacteriia	204432|Acidobacteriia	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_2138367_10	1267533.KB906733_gene3362	6.156e-102	349.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS2_k127_2154790_2	1267535.KB906767_gene609	4.425e-114	375.0	COG0172@1|root,COG0172@2|Bacteria,3Y2UD@57723|Acidobacteria,2JI0N@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TLS2_k127_2154790_0	204669.Acid345_0390	5.988e-157	511.0	COG1524@1|root,COG1524@2|Bacteria,3Y3M5@57723|Acidobacteria,2JHWD@204432|Acidobacteriia	204432|Acidobacteriia	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_2154790_1	204669.Acid345_0389	3.995e-137	461.0	COG0167@1|root,COG0167@2|Bacteria,3Y2K1@57723|Acidobacteria,2JHXE@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TLS2_k127_2154790_4	671143.DAMO_2589	7.575e-51	188.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Ubie_methyltran
TLS2_k127_2154790_3	204669.Acid345_4325	3.652e-51	185.0	2C1CU@1|root,32WCI@2|Bacteria,3Y553@57723|Acidobacteria,2JJTT@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2154790_5	1198114.AciX9_0908	1.313e-30	122.0	COG1235@1|root,COG1235@2|Bacteria,3Y3DW@57723|Acidobacteria,2JI3X@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_2159068_6	204669.Acid345_4523	1.41e-158	518.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,3Y6D3@57723|Acidobacteria,2JKGW@204432|Acidobacteriia	2|Bacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF,PAS_4,SpoIIE
TLS2_k127_2159068_0	204669.Acid345_4522	0.0	1036.0	COG1200@1|root,COG1200@2|Bacteria,3Y31Z@57723|Acidobacteria,2JHRS@204432|Acidobacteriia	204432|Acidobacteriia	L	ATP-dependent DNA helicase RecG	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
TLS2_k127_2159068_21	1123386.AUIW01000009_gene1813	1.205e-05	56.0	2DGZ3@1|root,2ZXUD@2|Bacteria,1WKRC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS2_k127_2159068_19	1123386.AUIW01000009_gene1812	1.009e-21	100.0	COG1848@1|root,COG1848@2|Bacteria,1WKJ4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2159068_4	204669.Acid345_4521	1.034e-168	542.0	COG1921@1|root,COG1921@2|Bacteria,3Y39V@57723|Acidobacteria,2JKCB@204432|Acidobacteriia	204432|Acidobacteriia	E	Selenocysteine synthase N terminal	-	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
TLS2_k127_2159068_18	240015.ACP_2296	1.963e-31	124.0	COG1278@1|root,COG1278@2|Bacteria,3Y5NU@57723|Acidobacteria,2JJUC@204432|Acidobacteriia	204432|Acidobacteriia	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_2159068_14	204669.Acid345_4518	1.736e-43	162.0	COG0736@1|root,COG0736@2|Bacteria,3Y590@57723|Acidobacteria,2JJPD@204432|Acidobacteriia	204432|Acidobacteriia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_2159068_9	204669.Acid345_4517	4.079e-122	408.0	COG1463@1|root,COG1463@2|Bacteria,3Y3SX@57723|Acidobacteria,2JIP6@204432|Acidobacteriia	204432|Acidobacteriia	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
TLS2_k127_2159068_8	1382359.JIAL01000001_gene1388	2.994e-150	479.0	COG0320@1|root,COG0320@2|Bacteria,3Y3D4@57723|Acidobacteria,2JI3W@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
TLS2_k127_2159068_17	204669.Acid345_4493	6.403e-33	132.0	COG3189@1|root,COG3189@2|Bacteria,3Y88F@57723|Acidobacteria,2JN90@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
TLS2_k127_2159068_1	204669.Acid345_4495	5.71e-208	659.0	COG2027@1|root,COG2027@2|Bacteria,3Y3WF@57723|Acidobacteria,2JIBN@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
TLS2_k127_2159068_11	204669.Acid345_4496	7.881e-92	315.0	COG0294@1|root,COG0294@2|Bacteria,3Y4JJ@57723|Acidobacteria,2JKCZ@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TLS2_k127_2159068_10	215803.DB30_4900	4.445e-106	364.0	COG1680@1|root,COG1680@2|Bacteria,1PEI7@1224|Proteobacteria,43DSW@68525|delta/epsilon subdivisions,2X8V3@28221|Deltaproteobacteria,2Z0DE@29|Myxococcales	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_2159068_13	292459.STH2430	3.201e-62	218.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia	186801|Clostridia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
TLS2_k127_2159068_15	1191523.MROS_1301	2.971e-38	150.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TLS2_k127_2159068_3	204669.Acid345_4501	1.296e-174	557.0	COG1228@1|root,COG1228@2|Bacteria,3Y6Y2@57723|Acidobacteria,2JK82@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2159068_7	204669.Acid345_4500	1.563e-153	501.0	COG1228@1|root,COG1228@2|Bacteria,3Y69U@57723|Acidobacteria,2JMB0@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2159068_16	204669.Acid345_4505	1.433e-35	136.0	COG0236@1|root,COG0236@2|Bacteria,3Y54V@57723|Acidobacteria,2JJPU@204432|Acidobacteriia	204432|Acidobacteriia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS2_k127_2159068_2	204669.Acid345_4506	4.936e-205	647.0	COG0304@1|root,COG0304@2|Bacteria,3Y3IS@57723|Acidobacteria,2JIGI@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS2_k127_2159068_5	204669.Acid345_4600	2.931e-163	527.0	COG0624@1|root,COG0624@2|Bacteria,3Y4G2@57723|Acidobacteria,2JJG2@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_2159068_12	204669.Acid345_0271	1.832e-66	237.0	COG2885@1|root,COG2885@2|Bacteria,3Y4AQ@57723|Acidobacteria,2JJ3G@204432|Acidobacteriia	204432|Acidobacteriia	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS2_k127_2184396_1	204669.Acid345_1410	1.42e-167	535.0	COG2986@1|root,COG2986@2|Bacteria,3Y3YW@57723|Acidobacteria,2JIK6@204432|Acidobacteriia	204432|Acidobacteriia	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
TLS2_k127_2184396_2	1304878.AUGD01000012_gene4154	2.036e-133	449.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TUKZ@28211|Alphaproteobacteria,3JXMK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Amidase	MA20_08765	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS2_k127_2184396_9	204669.Acid345_4558	4.722e-53	202.0	COG3710@1|root,COG3710@2|Bacteria,3Y7KB@57723|Acidobacteria,2JMW2@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS2_k127_2184396_4	204669.Acid345_1412	1.917e-92	306.0	COG2316@1|root,COG2316@2|Bacteria,3Y4GI@57723|Acidobacteria,2JJBG@204432|Acidobacteriia	204432|Acidobacteriia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
TLS2_k127_2184396_6	204669.Acid345_1414	8.311e-68	236.0	COG1396@1|root,COG1396@2|Bacteria,3Y4DV@57723|Acidobacteria,2JJ0U@204432|Acidobacteriia	204432|Acidobacteriia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS2_k127_2184396_5	745411.B3C1_14310	4.7e-73	274.0	COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,1RP7I@1236|Gammaproteobacteria,1J4FA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_2184396_3	204669.Acid345_1417	1.664e-111	366.0	COG0020@1|root,COG0020@2|Bacteria,3Y485@57723|Acidobacteria,2JI0B@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS2_k127_2184396_8	204669.Acid345_1418	2.147e-55	204.0	COG0575@1|root,COG0575@2|Bacteria	2|Bacteria	I	Belongs to the CDS family	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iIT341.HP0215,iLJ478.TM1397	CTP_transf_1
TLS2_k127_2184396_0	204669.Acid345_1419	8.335e-172	547.0	COG0743@1|root,COG0743@2|Bacteria,3Y30J@57723|Acidobacteria,2JI5H@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
TLS2_k127_2184396_7	1382359.JIAL01000001_gene2620	1.248e-63	222.0	COG0750@1|root,COG0750@2|Bacteria,3Y2KN@57723|Acidobacteria,2JI1B@204432|Acidobacteriia	204432|Acidobacteriia	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
TLS2_k127_2250674_5	1382359.JIAL01000001_gene2350	3.967e-105	346.0	COG0752@1|root,COG0752@2|Bacteria,3Y3QC@57723|Acidobacteria,2JI3H@204432|Acidobacteriia	204432|Acidobacteriia	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
TLS2_k127_2250674_1	204669.Acid345_1195	9.3e-246	777.0	COG0751@1|root,COG0751@2|Bacteria,3Y3KN@57723|Acidobacteria,2JIJ2@204432|Acidobacteriia	204432|Acidobacteriia	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
TLS2_k127_2250674_0	204669.Acid345_1196	0.0	1361.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,3Y2P5@57723|Acidobacteria,2JMA3@204432|Acidobacteriia	204432|Acidobacteriia	G	PEP-utilising enzyme, mobile domain	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS2_k127_2250674_2	1242864.D187_003348	2.988e-180	580.0	COG1524@1|root,COG1524@2|Bacteria	2|Bacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,HYR,Laminin_G_3,Phosphodiest
TLS2_k127_2250674_8	204669.Acid345_1203	4.303e-70	244.0	28J2W@1|root,2Z8Z6@2|Bacteria,3Y2KF@57723|Acidobacteria,2JIUG@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2250674_12	1454202.PPBDW_140160___1	0.0003504	43.0	2DT0U@1|root,33I6V@2|Bacteria,1NMHR@1224|Proteobacteria,1SGK7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2250674_11	1267534.KB906755_gene3947	0.0002035	46.0	COG4974@1|root,COG4974@2|Bacteria,3Y5GN@57723|Acidobacteria,2JJXR@204432|Acidobacteriia	204432|Acidobacteriia	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_2250674_4	269799.Gmet_2581	6.761e-110	362.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2WM0M@28221|Deltaproteobacteria,43S51@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	mscS-2	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
TLS2_k127_2250674_6	1068980.ARVW01000001_gene5702	4.537e-105	361.0	COG1228@1|root,COG1228@2|Bacteria,2I98N@201174|Actinobacteria,4E1HT@85010|Pseudonocardiales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
TLS2_k127_2250674_3	278963.ATWD01000001_gene4578	1.158e-136	445.0	COG0205@1|root,COG0205@2|Bacteria,3Y4A9@57723|Acidobacteria,2JK4R@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
TLS2_k127_2250674_7	84531.JMTZ01000010_gene3141	1.541e-74	261.0	2DCFR@1|root,2ZDYQ@2|Bacteria,1RB5X@1224|Proteobacteria,1RN4F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2250674_9	204669.Acid345_2701	1.045e-42	158.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_2290835_6	204669.Acid345_0104	3.723e-05	46.0	COG1610@1|root,COG1610@2|Bacteria,3Y4VF@57723|Acidobacteria,2JJJH@204432|Acidobacteriia	204432|Acidobacteriia	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS2_k127_2290835_4	204669.Acid345_0088	3.487e-47	175.0	COG0328@1|root,COG0328@2|Bacteria,3Y4EY@57723|Acidobacteria,2JJ1U@204432|Acidobacteriia	204432|Acidobacteriia	L	Reverse transcriptase-like	-	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
TLS2_k127_2290835_1	1198114.AciX9_3565	4.154e-90	303.0	COG0639@1|root,COG0639@2|Bacteria,3Y3U2@57723|Acidobacteria,2JIPQ@204432|Acidobacteriia	204432|Acidobacteriia	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
TLS2_k127_2290835_5	990285.RGCCGE502_03247	5.364e-26	116.0	2E31H@1|root,32Y1W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2290835_3	526222.Desal_1538	3.929e-59	220.0	COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,42N45@68525|delta/epsilon subdivisions,2WKUD@28221|Deltaproteobacteria,2M8FS@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
TLS2_k127_2290835_0	204669.Acid345_0091	2.426e-124	407.0	COG0444@1|root,COG0444@2|Bacteria,3Y3X6@57723|Acidobacteria,2JHNV@204432|Acidobacteriia	204432|Acidobacteriia	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_2290835_2	945713.IALB_0545	1.551e-73	257.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_2299153_2	204669.Acid345_1443	3.663e-171	548.0	COG1012@1|root,COG1012@2|Bacteria,3Y6J2@57723|Acidobacteria,2JMD6@204432|Acidobacteriia	204432|Acidobacteriia	C	Aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
TLS2_k127_2299153_6	234267.Acid_7046	8.824e-13	78.0	2FF7H@1|root,3475G@2|Bacteria,3Y8K8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2299153_3	1379698.RBG1_1C00001G0513	2.359e-132	437.0	COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS2_k127_2299153_4	204669.Acid345_1442	1.246e-128	426.0	COG0624@1|root,COG0624@2|Bacteria,3Y2XS@57723|Acidobacteria,2JINN@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase, M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_2299153_0	204669.Acid345_1441	1.205e-212	674.0	COG1574@1|root,COG1574@2|Bacteria,3Y453@57723|Acidobacteria,2JIB6@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_2299153_1	1382359.JIAL01000001_gene2704	9.241e-197	625.0	COG0612@1|root,COG0612@2|Bacteria,3Y3XF@57723|Acidobacteria,2JHR4@204432|Acidobacteriia	204432|Acidobacteriia	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_2299153_5	204669.Acid345_0621	3.642e-61	224.0	COG0612@1|root,COG0612@2|Bacteria,3Y322@57723|Acidobacteria,2JP25@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16_C
TLS2_k127_2336024_0	204669.Acid345_2365	4.137e-124	404.0	COG1703@1|root,COG1703@2|Bacteria,3Y40X@57723|Acidobacteria,2JHW8@204432|Acidobacteriia	204432|Acidobacteriia	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS2_k127_2336024_1	204669.Acid345_2364	3.543e-54	194.0	COG0346@1|root,COG0346@2|Bacteria,3Y5PU@57723|Acidobacteria,2JN0W@204432|Acidobacteriia	204432|Acidobacteriia	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
TLS2_k127_2336024_2	204669.Acid345_2363	9.89e-22	106.0	COG1214@1|root,COG1214@2|Bacteria,3Y5ED@57723|Acidobacteria,2JJSB@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM Peptidase M22, glycoprotease	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
TLS2_k127_2342780_3	204669.Acid345_4734	4.02e-13	69.0	28PH7@1|root,2ZC7R@2|Bacteria,3Y4CI@57723|Acidobacteria,2JJ15@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2342780_1	204669.Acid345_0724	2.305e-114	380.0	COG1215@1|root,COG1215@2|Bacteria,3Y2WN@57723|Acidobacteria,2JHSI@204432|Acidobacteriia	204432|Acidobacteriia	M	Glycosyl transferase family group 2	-	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
TLS2_k127_2342780_0	234267.Acid_0380	5.921e-129	427.0	COG1502@1|root,COG1502@2|Bacteria,3Y2GD@57723|Acidobacteria	57723|Acidobacteria	I	PLD-like domain	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
TLS2_k127_2342780_2	643562.Daes_0336	8.117e-51	185.0	COG3542@1|root,COG3542@2|Bacteria,1RHBE@1224|Proteobacteria,42T2P@68525|delta/epsilon subdivisions,2WPQ3@28221|Deltaproteobacteria,2MBSS@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Cupin superfamily (DUF985)	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
TLS2_k127_2342780_4	1172180.KB911776_gene564	4.283e-08	54.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_2376029_1	204669.Acid345_2470	8.109e-58	202.0	COG0183@1|root,COG0183@2|Bacteria,3Y2U4@57723|Acidobacteria,2JIS1@204432|Acidobacteriia	204432|Acidobacteriia	I	Thiolase, C-terminal domain	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_2376029_0	204669.Acid345_2469	2.513e-226	708.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,3Y2RB@57723|Acidobacteria,2JIRW@204432|Acidobacteriia	204432|Acidobacteriia	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1,ECH_2
TLS2_k127_2377153_1	1123242.JH636435_gene2291	1.215e-77	275.0	COG2327@1|root,COG2327@2|Bacteria	2|Bacteria	S	slime layer polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
TLS2_k127_2377153_2	1005048.CFU_3349	4.441e-26	121.0	COG0451@1|root,COG0451@2|Bacteria,1MVGI@1224|Proteobacteria,2VQFJ@28216|Betaproteobacteria	28216|Betaproteobacteria	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4
TLS2_k127_2377153_0	404589.Anae109_1212	3.999e-95	340.0	COG0204@1|root,COG1022@1|root,COG3320@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,COG3320@2|Bacteria,1MU4D@1224|Proteobacteria,42NHQ@68525|delta/epsilon subdivisions,2WJZ5@28221|Deltaproteobacteria,2YU6Q@29|Myxococcales	28221|Deltaproteobacteria	IQ	Male sterility protein	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,NAD_binding_4,PP-binding,Sterile
TLS2_k127_2377153_3	1254432.SCE1572_48400	8.46e-14	85.0	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,42TQ7@68525|delta/epsilon subdivisions,2WS2Q@28221|Deltaproteobacteria,2YXIZ@29|Myxococcales	28221|Deltaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
TLS2_k127_2377153_4	761193.Runsl_2757	5.249e-12	72.0	COG4319@1|root,COG4319@2|Bacteria,4NT0G@976|Bacteroidetes,47T3M@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_3
TLS2_k127_2384484_24	204669.Acid345_3770	2.513e-49	178.0	COG1201@1|root,COG1201@2|Bacteria,3Y348@57723|Acidobacteria,2JIVQ@204432|Acidobacteriia	204432|Acidobacteriia	L	dead deah	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
TLS2_k127_2384484_5	926550.CLDAP_07050	9.081e-164	526.0	COG2239@1|root,COG2239@2|Bacteria,2G6H7@200795|Chloroflexi	200795|Chloroflexi	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
TLS2_k127_2384484_16	204669.Acid345_3769	1.306e-75	262.0	COG1778@1|root,COG1778@2|Bacteria,3Y495@57723|Acidobacteria,2JJ33@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
TLS2_k127_2384484_23	204669.Acid345_3768	2.365e-52	195.0	COG0457@1|root,COG0457@2|Bacteria,3Y5A8@57723|Acidobacteria,2JNC1@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
TLS2_k127_2384484_1	204669.Acid345_1065	6.787e-312	978.0	COG0744@1|root,COG0744@2|Bacteria,3Y42I@57723|Acidobacteria,2JI7Q@204432|Acidobacteriia	204432|Acidobacteriia	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS2_k127_2384484_2	204669.Acid345_1063	5.243e-277	861.0	COG0442@1|root,COG0442@2|Bacteria,3Y329@57723|Acidobacteria,2JIBQ@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
TLS2_k127_2384484_9	1382359.JIAL01000001_gene1867	2.683e-125	409.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,3Y4I2@57723|Acidobacteria,2JIKP@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the SIS family. GutQ KpsF subfamily	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
TLS2_k127_2384484_21	1382359.JIAL01000001_gene1039	1.166e-57	217.0	28IJE@1|root,2Z8KB@2|Bacteria,3Y46I@57723|Acidobacteria,2JI72@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2384484_4	1267534.KB906756_gene140	1.96e-221	721.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y2YM@57723|Acidobacteria,2JKAC@204432|Acidobacteriia	204432|Acidobacteriia	K	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_17
TLS2_k127_2384484_11	1382359.JIAL01000001_gene143	1.805e-107	387.0	COG0477@1|root,COG2814@2|Bacteria,3Y47I@57723|Acidobacteria,2JJ64@204432|Acidobacteriia	204432|Acidobacteriia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_2384484_3	1382359.JIAL01000001_gene144	6.201e-275	863.0	COG2234@1|root,COG2234@2|Bacteria,3Y33F@57723|Acidobacteria,2JI7G@204432|Acidobacteriia	204432|Acidobacteriia	S	Transferrin receptor-like dimerisation domain	-	-	3.4.17.21	ko:K01301	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28,TFR_dimer
TLS2_k127_2384484_15	204669.Acid345_2342	1.105e-78	272.0	COG1985@1|root,COG1985@2|Bacteria	2|Bacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	-	-	1.1.1.193	ko:K00082	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R03458	RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	DDE_Tnp_1,DUF772,RibD_C,dCMP_cyt_deam_1
TLS2_k127_2384484_29	204669.Acid345_2343	5.958e-42	175.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,AMP-binding,Acyl_transf_1,DehI,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
TLS2_k127_2384484_17	204669.Acid345_2344	6.742e-69	245.0	2E19M@1|root,2ZCDB@2|Bacteria,3Y4DH@57723|Acidobacteria,2JJ2T@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2384484_13	1382359.JIAL01000001_gene3055	6.515e-103	345.0	COG1044@1|root,COG1044@2|Bacteria,3Y3XX@57723|Acidobacteria,2JHQA@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD2	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
TLS2_k127_2384484_7	204669.Acid345_2346	1.076e-127	419.0	COG1560@1|root,COG1560@2|Bacteria,3Y2RW@57723|Acidobacteria,2JIMS@204432|Acidobacteriia	204432|Acidobacteriia	M	lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
TLS2_k127_2384484_14	204669.Acid345_2347	1.928e-80	276.0	COG2930@1|root,COG2930@2|Bacteria,3Y2F0@57723|Acidobacteria,2JIT6@204432|Acidobacteriia	204432|Acidobacteriia	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
TLS2_k127_2384484_12	204669.Acid345_2348	5.741e-105	347.0	COG2197@1|root,COG2197@2|Bacteria,3Y54P@57723|Acidobacteria,2JJT9@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_2384484_34	401053.AciPR4_3335	3.278e-33	137.0	29C91@1|root,2ZZ7J@2|Bacteria,3Y4QX@57723|Acidobacteria,2JJAG@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2384484_8	290397.Adeh_0237	4.69e-126	449.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,1R5BE@1224|Proteobacteria,4339F@68525|delta/epsilon subdivisions,2WYFR@28221|Deltaproteobacteria,2YTXM@29|Myxococcales	28221|Deltaproteobacteria	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,DUF3858,TPR_16,TPR_19,TPR_8,Transglut_core
TLS2_k127_2384484_41	215803.DB30_1252	5.599e-21	109.0	COG0457@1|root,COG0457@2|Bacteria,1Q2H1@1224|Proteobacteria,4383J@68525|delta/epsilon subdivisions,2X3DM@28221|Deltaproteobacteria,2YVKC@29|Myxococcales	28221|Deltaproteobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,DUF3858,TPR_16,TPR_19
TLS2_k127_2384484_51	457425.XNR_1484	7.258e-05	52.0	28NJ6@1|root,2ZBKE@2|Bacteria,2IGYV@201174|Actinobacteria	201174|Actinobacteria	S	Beta protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_protein
TLS2_k127_2384484_0	204669.Acid345_3506	0.0	1110.0	COG1450@1|root,COG1629@1|root,COG1450@2|Bacteria,COG4771@2|Bacteria,3Y2R1@57723|Acidobacteria,2JIPI@204432|Acidobacteriia	204432|Acidobacteriia	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_2384484_47	204669.Acid345_3327	5.399e-13	74.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	HemolysinCabind,Metallophos
TLS2_k127_2384484_36	204669.Acid345_4658	3.277e-31	128.0	COG3861@1|root,COG3861@2|Bacteria	2|Bacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	puhA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009579,GO:0016020,GO:0034357,GO:0042716,GO:0042717,GO:0044424,GO:0044436,GO:0044444,GO:0044464	-	ko:K13991	ko02020,map02020	-	-	-	ko00000,ko00001,ko00194	-	-	-	DUF2382,PRC,PRCH
TLS2_k127_2384484_32	234267.Acid_1755	2.16e-35	145.0	COG2197@1|root,COG2197@2|Bacteria,3Y2WY@57723|Acidobacteria	57723|Acidobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_2384484_30	1267533.KB906737_gene1518	5.791e-41	158.0	COG0250@1|root,COG0250@2|Bacteria,3Y8J7@57723|Acidobacteria,2JNK2@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcription termination factor nusG	-	-	-	-	-	-	-	-	-	-	-	-	NusG
TLS2_k127_2384484_26	565045.NOR51B_2880	7.694e-48	194.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1J4NA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Type II secretory pathway component ExeA	gspA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1,T2SSB
TLS2_k127_2384484_48	926566.Terro_0204	5.196e-12	79.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria,2JI38@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TLS2_k127_2384484_42	1123070.KB899258_gene1891	1.622e-19	98.0	COG1596@1|root,COG1596@2|Bacteria,46ZHY@74201|Verrucomicrobia,2IUWB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Polysaccharide biosynthesis/export protein	-	-	-	-	-	-	-	-	-	-	-	-	Poly_export,SLBB
TLS2_k127_2384484_27	1267535.KB906767_gene2403	2.069e-45	183.0	COG3206@1|root,COG3206@2|Bacteria,3Y4H3@57723|Acidobacteria,2JJ3W@204432|Acidobacteriia	204432|Acidobacteriia	M	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzz
TLS2_k127_2384484_44	215803.DB30_3193	1.649e-15	86.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,42NB4@68525|delta/epsilon subdivisions,2WK9E@28221|Deltaproteobacteria,2YTU8@29|Myxococcales	28221|Deltaproteobacteria	D	protein involved in exopolysaccharide biosynthesis	wzc2	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
TLS2_k127_2384484_19	477974.Daud_1703	2.591e-60	219.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,24870@186801|Clostridia,266SI@186807|Peptococcaceae	186801|Clostridia	M	Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	-	-	2.7.8.6	ko:K00996	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Bac_transf,CoA_binding_3
TLS2_k127_2384484_50	1245471.PCA10_19790	3.72e-05	56.0	COG2244@1|root,COG2244@2|Bacteria,1NCIA@1224|Proteobacteria,1S599@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
TLS2_k127_2384484_37	526225.Gobs_0360	9.549e-30	133.0	COG3173@1|root,COG3173@2|Bacteria,2H3VQ@201174|Actinobacteria	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_2384484_28	1340493.JNIF01000002_gene1239	7.521e-44	174.0	COG0726@1|root,COG0726@2|Bacteria,3Y5MF@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_2384484_25	1144275.COCOR_02989	3.878e-48	187.0	COG0399@1|root,COG0399@2|Bacteria,1REP8@1224|Proteobacteria,42S4Y@68525|delta/epsilon subdivisions,2WNVT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_2384484_22	886293.Sinac_2473	4.099e-53	208.0	COG5653@1|root,COG5653@2|Bacteria,2J18H@203682|Planctomycetes	203682|Planctomycetes	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
TLS2_k127_2384484_18	1242864.D187_010001	1.125e-66	243.0	COG5653@1|root,COG5653@2|Bacteria,1NCB6@1224|Proteobacteria,430DK@68525|delta/epsilon subdivisions,2WVKU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
TLS2_k127_2384484_35	383372.Rcas_3103	4.152e-33	145.0	COG3307@1|root,COG3307@2|Bacteria,2GB55@200795|Chloroflexi,377AJ@32061|Chloroflexia	32061|Chloroflexia	M	PFAM O-antigen polymerase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TLS2_k127_2384484_6	357808.RoseRS_2371	2.172e-139	454.0	COG0438@1|root,COG0438@2|Bacteria,2G9B8@200795|Chloroflexi,376I5@32061|Chloroflexia	32061|Chloroflexia	H	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_2384484_10	316274.Haur_3583	7.406e-108	362.0	COG1215@1|root,COG1215@2|Bacteria,2GAJA@200795|Chloroflexi,376HJ@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
TLS2_k127_2384484_43	1125863.JAFN01000001_gene3145	1.37e-15	91.0	2DKW5@1|root,30J7Z@2|Bacteria,1N7B9@1224|Proteobacteria,42XV2@68525|delta/epsilon subdivisions,2X6CB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2384484_31	1267534.KB906757_gene911	1.33e-38	164.0	COG3867@1|root,COG4257@1|root,COG3867@2|Bacteria,COG4257@2|Bacteria,3Y9AI@57723|Acidobacteria	57723|Acidobacteria	V	Putative Ig domain	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
TLS2_k127_2384484_33	1194972.MVAC_26522	3.651e-35	147.0	2DKW5@1|root,30J7Z@2|Bacteria,2IMFS@201174|Actinobacteria,2372W@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2384484_49	278963.ATWD01000001_gene4376	2.238e-06	51.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,3Y3F8@57723|Acidobacteria,2JKAW@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
TLS2_k127_2430626_0	204669.Acid345_4736	0.0	1054.0	COG0441@1|root,COG0441@2|Bacteria,3Y2V0@57723|Acidobacteria,2JHV7@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
TLS2_k127_2430626_1	204669.Acid345_2229	1.136e-233	747.0	COG0308@1|root,COG0308@2|Bacteria,3Y7E9@57723|Acidobacteria,2JMED@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
TLS2_k127_244963_1	240015.ACP_0530	6.24e-47	189.0	COG4254@1|root,COG4254@2|Bacteria,3Y58Q@57723|Acidobacteria,2JJSD@204432|Acidobacteriia	204432|Acidobacteriia	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
TLS2_k127_244963_2	639030.JHVA01000001_gene757	1.12e-22	109.0	2E8J4@1|root,332WZ@2|Bacteria,3Y5J7@57723|Acidobacteria,2JJYI@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_244963_0	204669.Acid345_3618	9.254e-60	211.0	COG0817@1|root,COG0817@2|Bacteria,3Y4DS@57723|Acidobacteria,2JJ30@204432|Acidobacteriia	204432|Acidobacteriia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
TLS2_k127_2488571_3	207954.MED92_08981	1.963e-05	56.0	2EMQC@1|root,33FCV@2|Bacteria,1NZUP@1224|Proteobacteria,1SRZ2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2488571_2	204669.Acid345_4277	3.262e-120	405.0	COG0457@1|root,COG0457@2|Bacteria	204669.Acid345_4277|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2488571_1	204669.Acid345_4276	2.838e-216	702.0	COG0308@1|root,COG0308@2|Bacteria,3Y31F@57723|Acidobacteria,2JMCB@204432|Acidobacteriia	204432|Acidobacteriia	M	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
TLS2_k127_2488571_0	1185652.USDA257_c04170	5.21e-274	864.0	COG3408@1|root,COG3408@2|Bacteria,1MUYU@1224|Proteobacteria,2TQK2@28211|Alphaproteobacteria,4B9N1@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Protein involved in amylo-alpha-1,6-glucosidase activity and glycogen biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
TLS2_k127_2488571_4	1440053.JOEI01000032_gene5402	0.0001006	53.0	2B10M@1|root,31TDX@2|Bacteria,2GS84@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2522776_0	1396418.BATQ01000166_gene1865	1.046e-57	207.0	COG4805@1|root,COG4805@2|Bacteria,46XD2@74201|Verrucomicrobia,2IVH8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS2_k127_2522776_1	1382359.JIAL01000001_gene1844	5.206e-47	170.0	COG1225@1|root,COG1225@2|Bacteria,3Y7S8@57723|Acidobacteria,2JN1P@204432|Acidobacteriia	204432|Acidobacteriia	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS2_k127_2522776_3	269084.syc2287_c	4.821e-14	72.0	COG1225@1|root,COG1225@2|Bacteria,1G6AA@1117|Cyanobacteria,1H09N@1129|Synechococcus	1117|Cyanobacteria	O	Bacterioferritin comigratory	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS2_k127_2522776_2	240015.ACP_2289	5.437e-22	109.0	28JPX@1|root,2Z9FV@2|Bacteria,3Y48N@57723|Acidobacteria,2JHSH@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2612647_0	204669.Acid345_3065	4.728e-278	862.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,3Y5CQ@57723|Acidobacteria,2JKVX@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO
TLS2_k127_2612647_10	240015.ACP_1829	5.837e-34	135.0	2DNS7@1|root,32YWC@2|Bacteria,3Y609@57723|Acidobacteria,2JK5C@204432|Acidobacteriia	204432|Acidobacteriia	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
TLS2_k127_2612647_2	204669.Acid345_3700	4.176e-152	486.0	COG2025@1|root,COG2025@2|Bacteria,3Y4SJ@57723|Acidobacteria,2JP3Y@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein FAD-binding domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TLS2_k127_2612647_3	204669.Acid345_3697	3.113e-130	425.0	COG2086@1|root,COG2086@2|Bacteria,3Y2PD@57723|Acidobacteria,2JK7K@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
TLS2_k127_2612647_6	1304885.AUEY01000040_gene1599	3.153e-91	325.0	COG0168@1|root,COG0168@2|Bacteria,1N412@1224|Proteobacteria,42MBI@68525|delta/epsilon subdivisions,2WIZ9@28221|Deltaproteobacteria,2MI8M@213118|Desulfobacterales	28221|Deltaproteobacteria	P	TIGRFAM potassium uptake protein, TrkH family	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS2_k127_2612647_5	1304885.AUEY01000040_gene1599	1.01e-93	328.0	COG0168@1|root,COG0168@2|Bacteria,1N412@1224|Proteobacteria,42MBI@68525|delta/epsilon subdivisions,2WIZ9@28221|Deltaproteobacteria,2MI8M@213118|Desulfobacterales	28221|Deltaproteobacteria	P	TIGRFAM potassium uptake protein, TrkH family	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS2_k127_2612647_8	1232410.KI421420_gene3141	1.585e-51	190.0	COG0569@1|root,COG0569@2|Bacteria,1R7KM@1224|Proteobacteria,42PJH@68525|delta/epsilon subdivisions,2WMZT@28221|Deltaproteobacteria,43SGD@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain	ktrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS2_k127_2612647_9	204669.Acid345_3695	3.948e-40	150.0	2BYAI@1|root,315Y9@2|Bacteria,3Y52S@57723|Acidobacteria,2JJJK@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2612647_11	1267534.KB906760_gene1503	0.0001546	46.0	2EGBS@1|root,33A3K@2|Bacteria,3Y5X9@57723|Acidobacteria,2JK4S@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2612647_7	292415.Tbd_1259	3.628e-54	199.0	COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,2VUZW@28216|Betaproteobacteria,1KSDS@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
TLS2_k127_2612647_4	1121012.AUKX01000022_gene2458	6.355e-98	329.0	COG2159@1|root,COG2159@2|Bacteria,4NJP9@976|Bacteroidetes,1HXKV@117743|Flavobacteriia,23FXD@178469|Arenibacter	976|Bacteroidetes	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_2612647_1	1254432.SCE1572_17235	1.488e-261	826.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TLS2_k127_2640416_4	204669.Acid345_2470	1.157e-59	207.0	COG0183@1|root,COG0183@2|Bacteria,3Y2U4@57723|Acidobacteria,2JIS1@204432|Acidobacteriia	204432|Acidobacteriia	I	Thiolase, C-terminal domain	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_2640416_0	204669.Acid345_2471	2.65e-265	828.0	COG1960@1|root,COG1960@2|Bacteria,3Y2NA@57723|Acidobacteria,2JII2@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_2640416_2	204669.Acid345_3344	7.422e-64	231.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria,2JIK2@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
TLS2_k127_2640416_6	204669.Acid345_1595	1.141e-29	121.0	2CBEB@1|root,32STF@2|Bacteria,3Y5AC@57723|Acidobacteria,2JJNZ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2640416_5	204669.Acid345_1594	5.006e-50	186.0	COG0457@1|root,COG0457@2|Bacteria,3Y4VN@57723|Acidobacteria,2JJG5@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF2911)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2911
TLS2_k127_2640416_3	1250232.JQNJ01000001_gene3838	3.35e-63	221.0	COG2080@1|root,COG2080@2|Bacteria,4NM72@976|Bacteroidetes,1I17D@117743|Flavobacteriia	976|Bacteroidetes	C	Aerobic-type carbon monoxide dehydrogenase small subunit CoxS	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_2640416_1	1519464.HY22_04515	6.68e-115	390.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	iorB	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_2806457_14	204669.Acid345_4604	1.318e-35	145.0	2CK8F@1|root,34A9U@2|Bacteria,3Y8M8@57723|Acidobacteria,2JNFT@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2806457_10	204669.Acid345_4605	1.572e-72	266.0	2BY0I@1|root,33X0D@2|Bacteria,3Y818@57723|Acidobacteria,2JN4U@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2806457_5	204669.Acid345_4606	1.985e-152	493.0	COG5617@1|root,COG5617@2|Bacteria,3Y6ET@57723|Acidobacteria,2JMH1@204432|Acidobacteriia	204432|Acidobacteriia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2806457_2	204669.Acid345_4607	3.449e-243	764.0	COG5617@1|root,COG5617@2|Bacteria,3Y70C@57723|Acidobacteria,2JM19@204432|Acidobacteriia	204432|Acidobacteriia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2806457_0	204669.Acid345_4608	0.0	1560.0	COG0457@1|root,COG3063@1|root,COG0457@2|Bacteria,COG3063@2|Bacteria,3Y7E6@57723|Acidobacteria,2JMHJ@204432|Acidobacteriia	204432|Acidobacteriia	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
TLS2_k127_2806457_3	204669.Acid345_4609	6.858e-195	616.0	COG0438@1|root,COG0438@2|Bacteria,3Y641@57723|Acidobacteria,2JKAR@204432|Acidobacteriia	204432|Acidobacteriia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2806457_18	1048339.KB913029_gene4111	1.41e-05	57.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,4ERX2@85013|Frankiales	201174|Actinobacteria	M	alpha beta alpha domain I	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
TLS2_k127_2806457_12	204669.Acid345_4611	8.542e-48	175.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
TLS2_k127_2806457_7	204669.Acid345_4612	2.14e-129	428.0	COG2244@1|root,COG2244@2|Bacteria,3Y797@57723|Acidobacteria,2JM88@204432|Acidobacteriia	204432|Acidobacteriia	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2806457_9	204669.Acid345_4613	6.658e-81	282.0	295FI@1|root,2ZSTA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2806457_16	204669.Acid345_4614	4.21e-17	89.0	2CK8G@1|root,2ZP4A@2|Bacteria,3Y8Z3@57723|Acidobacteria,2JNVE@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2806457_8	204669.Acid345_4615	7.153e-82	279.0	COG0125@1|root,COG0125@2|Bacteria,3Y7XK@57723|Acidobacteria,2JMWZ@204432|Acidobacteriia	204432|Acidobacteriia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2806457_4	1123234.AUKI01000019_gene550	6.089e-154	507.0	COG0277@1|root,COG0277@2|Bacteria,4NHFC@976|Bacteroidetes,1HYJ4@117743|Flavobacteriia	976|Bacteroidetes	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,DUF805,FAD_binding_4
TLS2_k127_2806457_1	204669.Acid345_0175	0.0	1124.0	COG0317@1|root,COG0317@2|Bacteria,3Y38Q@57723|Acidobacteria,2JIN0@204432|Acidobacteriia	204432|Acidobacteriia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TLS2_k127_2806457_11	1396141.BATP01000047_gene3930	1.835e-48	177.0	COG3476@1|root,COG3476@2|Bacteria,46SXT@74201|Verrucomicrobia,2IVZD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	TspO/MBR family	-	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
TLS2_k127_2806457_17	1382358.JHVN01000014_gene1589	1.272e-11	72.0	COG0330@1|root,COG0330@2|Bacteria,1TR6S@1239|Firmicutes,4HKDW@91061|Bacilli	91061|Bacilli	O	Membrane protease subunits, stomatin prohibitin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_2806457_13	264732.Moth_1495	2.73e-44	164.0	COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,24J8Y@186801|Clostridia,42GJ3@68295|Thermoanaerobacterales	186801|Clostridia	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
TLS2_k127_2806457_6	204669.Acid345_4119	1.434e-149	476.0	COG1235@1|root,COG1235@2|Bacteria	2|Bacteria	P	May be involved in the transport of PQQ or its precursor to the periplasm	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
TLS2_k127_2806457_19	446468.Ndas_5438	0.0007259	45.0	COG3467@1|root,COG3467@2|Bacteria,2IQIK@201174|Actinobacteria,4EK1T@85012|Streptosporangiales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_2811584_49	1242864.D187_007675	7.498e-48	180.0	COG5285@1|root,COG5285@2|Bacteria,1R9W1@1224|Proteobacteria	1224|Proteobacteria	Q	phytanoyl-CoA dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS2_k127_2811584_41	682795.AciX8_1360	2.307e-66	234.0	COG0311@1|root,COG0311@2|Bacteria,3Y4GN@57723|Acidobacteria,2JJ3V@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
TLS2_k127_2811584_36	234267.Acid_5589	5.081e-78	269.0	COG1622@1|root,COG1622@2|Bacteria,3Y4UA@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase subunit II	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
TLS2_k127_2811584_7	1267533.KB906738_gene2145	1.503e-202	646.0	COG0843@1|root,COG0843@2|Bacteria,3Y2NS@57723|Acidobacteria,2JHVG@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS2_k127_2811584_50	204669.Acid345_2023	9.403e-48	180.0	COG1845@1|root,COG1845@2|Bacteria,3Y2KJ@57723|Acidobacteria,2JIED@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
TLS2_k127_2811584_40	234267.Acid_5592	3.638e-67	234.0	COG1845@1|root,COG1845@2|Bacteria,3Y5GJ@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
TLS2_k127_2811584_0	204669.Acid345_2022	0.0	1420.0	COG0178@1|root,COG0178@2|Bacteria,3Y3PA@57723|Acidobacteria,2JISM@204432|Acidobacteriia	204432|Acidobacteriia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_2811584_28	204669.Acid345_2021	1.458e-96	333.0	COG0457@1|root,COG0457@2|Bacteria,3Y3TS@57723|Acidobacteria,2JIJ1@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19
TLS2_k127_2811584_60	204669.Acid345_2019	8.583e-23	106.0	2CKY5@1|root,32WNR@2|Bacteria,3Y5B7@57723|Acidobacteria,2JJTK@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2811584_30	204669.Acid345_2018	1.917e-91	305.0	COG1451@1|root,COG1451@2|Bacteria,3Y2SM@57723|Acidobacteria,2JHKB@204432|Acidobacteriia	204432|Acidobacteriia	S	nucleotide metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2811584_19	204669.Acid345_1862	4.862e-117	390.0	COG0810@1|root,COG0810@2|Bacteria,3Y4BU@57723|Acidobacteria,2JJ3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
TLS2_k127_2811584_1	204669.Acid345_1861	0.0	1306.0	COG0060@1|root,COG0060@2|Bacteria,3Y3JW@57723|Acidobacteria,2JIQ2@204432|Acidobacteriia	204432|Acidobacteriia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
TLS2_k127_2811584_52	204669.Acid345_1860	3.506e-43	167.0	COG0597@1|root,COG0597@2|Bacteria,3Y55H@57723|Acidobacteria,2JJN7@204432|Acidobacteriia	204432|Acidobacteriia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
TLS2_k127_2811584_11	204669.Acid345_2691	4.162e-161	544.0	COG0457@1|root,COG0741@1|root,COG1729@1|root,COG0457@2|Bacteria,COG0741@2|Bacteria,COG1729@2|Bacteria,3Y2UJ@57723|Acidobacteria,2JIUE@204432|Acidobacteriia	204432|Acidobacteriia	M	Transglycosylase SLT domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_16,YfiO
TLS2_k127_2811584_53	204669.Acid345_2692	4.743e-43	172.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2811584_26	204669.Acid345_2693	2.015e-99	327.0	COG1595@1|root,COG1595@2|Bacteria,3Y3BS@57723|Acidobacteria,2JIDF@204432|Acidobacteriia	204432|Acidobacteriia	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2811584_56	204669.Acid345_2694	5.591e-33	129.0	COG5660@1|root,COG5660@2|Bacteria,3Y5KK@57723|Acidobacteria,2JJW4@204432|Acidobacteriia	204432|Acidobacteriia	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_2811584_62	204669.Acid345_2695	2.875e-18	86.0	2C7DG@1|root,2ZTXV@2|Bacteria,3Y94Z@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2811584_16	204669.Acid345_2567	5.761e-137	444.0	COG4783@1|root,COG4783@2|Bacteria,3Y3GF@57723|Acidobacteria,2JI98@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS2_k127_2811584_5	204669.Acid345_2392	2.749e-225	714.0	COG1260@1|root,COG1260@2|Bacteria,3Y325@57723|Acidobacteria,2JIPN@204432|Acidobacteriia	204432|Acidobacteriia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
TLS2_k127_2811584_25	204669.Acid345_2393	7.767e-106	355.0	COG4221@1|root,COG4221@2|Bacteria,3Y51J@57723|Acidobacteria,2JMDR@204432|Acidobacteriia	204432|Acidobacteriia	S	Fungal family of unknown function (DUF1776)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_2811584_24	234267.Acid_0345	3.343e-106	351.0	COG3253@1|root,COG3253@2|Bacteria,3Y39D@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
TLS2_k127_2811584_23	204669.Acid345_1954	4.602e-107	352.0	COG0177@1|root,COG0177@2|Bacteria,3Y3QD@57723|Acidobacteria,2JI6M@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TLS2_k127_2811584_34	204669.Acid345_2562	5.755e-86	292.0	COG1587@1|root,COG1587@2|Bacteria,3Y4W1@57723|Acidobacteria,2JJFE@204432|Acidobacteriia	204432|Acidobacteriia	H	synthase	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
TLS2_k127_2811584_20	204669.Acid345_2563	1.516e-115	381.0	COG0181@1|root,COG0181@2|Bacteria,3Y3RY@57723|Acidobacteria,2JIR3@204432|Acidobacteriia	204432|Acidobacteriia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
TLS2_k127_2811584_10	204669.Acid345_2564	6.401e-172	560.0	COG0373@1|root,COG0373@2|Bacteria,3Y3DQ@57723|Acidobacteria,2JHR3@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
TLS2_k127_2811584_29	204669.Acid345_2565	1.133e-91	316.0	COG4137@1|root,COG4137@2|Bacteria,3Y9FX@57723|Acidobacteria,2JP17@204432|Acidobacteriia	204432|Acidobacteriia	S	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
TLS2_k127_2811584_35	861299.J421_0889	5.664e-82	283.0	COG2367@1|root,COG2367@2|Bacteria	2|Bacteria	V	Beta-lactamase	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
TLS2_k127_2811584_12	204669.Acid345_2696	1.06e-147	475.0	COG1085@1|root,COG1085@2|Bacteria,3Y41K@57723|Acidobacteria	2|Bacteria	C	Galactose-1-phosphate uridyl transferase, N-terminal domain	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_transf
TLS2_k127_2811584_4	1279009.ADICEAN_00512	2.56e-242	765.0	COG0308@1|root,COG0308@2|Bacteria,4NFT0@976|Bacteroidetes,47M3W@768503|Cytophagia	976|Bacteroidetes	E	Leukotriene A4 hydrolase, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Leuk-A4-hydro_C,Peptidase_M1
TLS2_k127_2811584_2	204669.Acid345_2697	0.0	1255.0	COG0249@1|root,COG0249@2|Bacteria,3Y2J5@57723|Acidobacteria,2JHTC@204432|Acidobacteriia	204432|Acidobacteriia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
TLS2_k127_2811584_31	1382359.JIAL01000001_gene190	8.336e-91	312.0	COG1472@1|root,COG1472@2|Bacteria,3Y32Y@57723|Acidobacteria,2JIFE@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
TLS2_k127_2811584_21	1267534.KB906755_gene4333	1.947e-111	372.0	COG2377@1|root,COG2377@2|Bacteria,3Y3CU@57723|Acidobacteria,2JI1E@204432|Acidobacteriia	204432|Acidobacteriia	O	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
TLS2_k127_2811584_8	204669.Acid345_1988	4.89e-200	640.0	COG0747@1|root,COG0747@2|Bacteria,3Y44K@57723|Acidobacteria,2JHM9@204432|Acidobacteriia	204432|Acidobacteriia	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_2811584_22	278963.ATWD01000003_gene175	2.46e-110	363.0	COG1692@1|root,COG1692@2|Bacteria,3Y3YJ@57723|Acidobacteria,2JIAY@204432|Acidobacteriia	204432|Acidobacteriia	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
TLS2_k127_2811584_13	204669.Acid345_2522	4.588e-145	481.0	COG4796@1|root,COG4796@2|Bacteria,3Y37F@57723|Acidobacteria,2JI0Q@204432|Acidobacteriia	204432|Acidobacteriia	U	Belongs to the GSP D family	-	-	-	-	-	-	-	-	-	-	-	-	Secretin
TLS2_k127_2811584_6	240015.ACP_0671	4.895e-204	649.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,3Y3QY@57723|Acidobacteria,2JHPJ@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
TLS2_k127_2811584_38	204669.Acid345_2417	1.068e-69	253.0	2D61V@1|root,32TKB@2|Bacteria,3Y5CF@57723|Acidobacteria,2JNZW@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2811584_54	401053.AciPR4_1940	5.313e-38	158.0	COG1266@1|root,COG1266@2|Bacteria,3Y4ED@57723|Acidobacteria,2JJ3Q@204432|Acidobacteriia	204432|Acidobacteriia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_2811584_47	204669.Acid345_2432	1.709e-50	194.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
TLS2_k127_2811584_15	1123392.AQWL01000002_gene1980	2.623e-139	462.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2VH08@28216|Betaproteobacteria,1KSIB@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
TLS2_k127_2811584_43	234267.Acid_7537	4.542e-63	234.0	COG2717@1|root,COG2717@2|Bacteria,3Y58Y@57723|Acidobacteria	57723|Acidobacteria	C	Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
TLS2_k127_2811584_27	204669.Acid345_2252	8.987e-98	321.0	COG0377@1|root,COG0377@2|Bacteria,3Y475@57723|Acidobacteria,2JHSW@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TLS2_k127_2811584_14	204669.Acid345_2645	2.122e-140	456.0	COG0604@1|root,COG0604@2|Bacteria,3Y3PP@57723|Acidobacteria,2JJ3F@204432|Acidobacteriia	204432|Acidobacteriia	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_2811584_18	204669.Acid345_2647	8.961e-125	406.0	COG1975@1|root,COG1975@2|Bacteria,3Y54Y@57723|Acidobacteria,2JP44@204432|Acidobacteriia	204432|Acidobacteriia	C	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS2_k127_2811584_37	204669.Acid345_2648	1.272e-71	247.0	COG2068@1|root,COG2068@2|Bacteria	2|Bacteria	NU	MobA-Related Protein	nboR	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TLS2_k127_2811584_59	204669.Acid345_2651	6.97e-27	113.0	COG0822@1|root,COG0822@2|Bacteria,3Y4B9@57723|Acidobacteria	57723|Acidobacteria	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS2_k127_2811584_32	1235803.C825_01776	2.156e-87	302.0	COG0535@1|root,COG0535@2|Bacteria,4PA9R@976|Bacteroidetes,2FWDR@200643|Bacteroidia	976|Bacteroidetes	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
TLS2_k127_2811584_33	204669.Acid345_2652	4.849e-86	298.0	COG0614@1|root,COG0614@2|Bacteria,3Y5HR@57723|Acidobacteria,2JKX0@204432|Acidobacteriia	204432|Acidobacteriia	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS2_k127_2811584_45	204669.Acid345_2653	1.089e-53	198.0	COG1956@1|root,COG1956@2|Bacteria,3Y4UF@57723|Acidobacteria,2JJHH@204432|Acidobacteriia	204432|Acidobacteriia	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF_2
TLS2_k127_2811584_51	240015.ACP_2978	2.477e-44	170.0	COG0494@1|root,COG0494@2|Bacteria,3Y55X@57723|Acidobacteria,2JN43@204432|Acidobacteriia	204432|Acidobacteriia	L	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS2_k127_2811584_48	204669.Acid345_2515	2.118e-49	180.0	COG2172@1|root,COG2172@2|Bacteria,3Y4TY@57723|Acidobacteria,2JJGJ@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
TLS2_k127_2811584_46	926566.Terro_2784	5.842e-53	193.0	COG1366@1|root,COG1366@2|Bacteria,3Y4U6@57723|Acidobacteria,2JJH2@204432|Acidobacteriia	204432|Acidobacteriia	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS2_k127_2811584_57	204669.Acid345_1837	5.824e-32	133.0	2ET93@1|root,33KT4@2|Bacteria,3Y5XM@57723|Acidobacteria,2JK3T@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2811584_17	204669.Acid345_1835	1.438e-130	432.0	COG1215@1|root,COG1215@2|Bacteria,3Y2GM@57723|Acidobacteria,2JI7F@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS2_k127_2811584_44	1382359.JIAL01000001_gene517	8.465e-63	218.0	COG0780@1|root,COG0780@2|Bacteria,3Y4ND@57723|Acidobacteria,2JJ9J@204432|Acidobacteriia	204432|Acidobacteriia	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
TLS2_k127_2811584_39	204669.Acid345_1831	3.031e-68	247.0	COG1295@1|root,COG1295@2|Bacteria,3Y3RZ@57723|Acidobacteria,2JIYV@204432|Acidobacteriia	204432|Acidobacteriia	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_2811584_3	240015.ACP_3030	9.377e-265	821.0	COG1032@1|root,COG1032@2|Bacteria,3Y2QU@57723|Acidobacteria,2JI2U@204432|Acidobacteriia	204432|Acidobacteriia	C	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnJ	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
TLS2_k127_2811584_55	204669.Acid345_2320	5.654e-35	138.0	COG2510@1|root,COG2510@2|Bacteria,3Y598@57723|Acidobacteria,2JJMR@204432|Acidobacteriia	204432|Acidobacteriia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_2811584_58	1267533.KB906739_gene2517	1.075e-29	123.0	COG2510@1|root,COG2510@2|Bacteria,3Y549@57723|Acidobacteria,2JJSK@204432|Acidobacteriia	204432|Acidobacteriia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	EamA,TMEM234
TLS2_k127_2811584_9	204669.Acid345_1747	2.377e-177	567.0	COG1233@1|root,COG3349@1|root,COG1233@2|Bacteria,COG3349@2|Bacteria,3Y3PB@57723|Acidobacteria,2JIW6@204432|Acidobacteriia	204432|Acidobacteriia	C	FAD dependent oxidoreductase	-	-	1.3.5.6	ko:K00514	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R04798,R04800,R07511,R09656,R09658	RC01214,RC01959	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS2_k127_2811584_42	204669.Acid345_1746	8.029e-64	224.0	COG1562@1|root,COG1562@2|Bacteria,3Y3YX@57723|Acidobacteria,2JIHF@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM Squalene phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
TLS2_k127_2815475_2	204669.Acid345_0718	1.121e-170	549.0	COG0072@1|root,COG0072@2|Bacteria,3Y353@57723|Acidobacteria,2JIM2@204432|Acidobacteriia	204432|Acidobacteriia	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB
TLS2_k127_2815475_11	1123057.P872_18270	3.328e-58	217.0	COG0079@1|root,COG0079@2|Bacteria,4NEW8@976|Bacteroidetes,47PVQ@768503|Cytophagia	976|Bacteroidetes	E	Aminotransferase class-V	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_2815475_16	204669.Acid345_0719	3.129e-21	97.0	2ESG3@1|root,33K0W@2|Bacteria,3Y5YI@57723|Acidobacteria,2JK4B@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2815475_15	204669.Acid345_0720	1.257e-27	115.0	COG3027@1|root,COG3027@2|Bacteria,3Y5IJ@57723|Acidobacteria,2JJZS@204432|Acidobacteriia	204432|Acidobacteriia	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
TLS2_k127_2815475_9	204669.Acid345_2869	1.199e-93	314.0	COG0682@1|root,COG0682@2|Bacteria,3Y4HT@57723|Acidobacteria,2JJTI@204432|Acidobacteriia	204432|Acidobacteriia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	-	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
TLS2_k127_2815475_14	1037409.BJ6T_87330	2.112e-35	145.0	COG0596@1|root,COG0596@2|Bacteria,1R9VJ@1224|Proteobacteria,2U26I@28211|Alphaproteobacteria,3JQRZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_2815475_7	204669.Acid345_3345	1.011e-106	362.0	COG0564@1|root,COG0564@2|Bacteria,3Y3G8@57723|Acidobacteria,2JHXC@204432|Acidobacteriia	204432|Acidobacteriia	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_2815475_4	204669.Acid345_3344	5.493e-119	394.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria,2JIK2@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
TLS2_k127_2815475_5	204669.Acid345_0705	5.102e-110	366.0	COG2304@1|root,COG2304@2|Bacteria,3Y2PC@57723|Acidobacteria,2JI8N@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_2815475_8	204669.Acid345_0706	4.706e-106	359.0	COG2304@1|root,COG2304@2|Bacteria,3Y2QN@57723|Acidobacteria,2JI49@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2815475_6	204669.Acid345_0708	4.305e-108	352.0	COG1100@1|root,COG1100@2|Bacteria,3Y7CQ@57723|Acidobacteria	57723|Acidobacteria	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
TLS2_k127_2815475_10	1382359.JIAL01000001_gene2363	7.194e-88	308.0	COG4783@1|root,COG4783@2|Bacteria,3Y6B5@57723|Acidobacteria,2JK7Z@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS2_k127_2815475_0	204669.Acid345_0710	1.145e-209	657.0	COG0542@1|root,COG0542@2|Bacteria,3Y463@57723|Acidobacteria,2JMAK@204432|Acidobacteriia	204432|Acidobacteriia	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
TLS2_k127_2815475_3	1382359.JIAL01000001_gene2357	1.134e-141	455.0	COG0115@1|root,COG0115@2|Bacteria,3Y32X@57723|Acidobacteria,2JI58@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS2_k127_2815475_13	1340493.JNIF01000003_gene4475	1.676e-39	153.0	COG2318@1|root,COG2318@2|Bacteria,3Y8H7@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
TLS2_k127_2815475_17	204669.Acid345_3904	2.539e-14	85.0	COG0790@1|root,COG3266@1|root,COG0790@2|Bacteria,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	ko:K02450,ko:K07126,ko:K15539	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	DUF4115,HTH_25,Sel1,TNT
TLS2_k127_2815475_1	204669.Acid345_0704	1.879e-209	656.0	COG2805@1|root,COG2805@2|Bacteria,3Y316@57723|Acidobacteria,2JIT4@204432|Acidobacteriia	204432|Acidobacteriia	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TLS2_k127_2815475_12	1382359.JIAL01000001_gene2988	2.385e-48	179.0	COG2137@1|root,COG2137@2|Bacteria,3Y4WT@57723|Acidobacteria,2JJMB@204432|Acidobacteriia	204432|Acidobacteriia	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
TLS2_k127_2820586_1	118163.Ple7327_1377	1.723e-52	186.0	COG1208@1|root,COG1208@2|Bacteria,1G00Y@1117|Cyanobacteria,3VIEN@52604|Pleurocapsales	1117|Cyanobacteria	JM	COGs COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon)	-	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
TLS2_k127_2820586_0	357808.RoseRS_2385	1.662e-154	496.0	COG0451@1|root,COG0451@2|Bacteria,2GAMV@200795|Chloroflexi,376SP@32061|Chloroflexia	32061|Chloroflexia	M	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_2820586_2	1499967.BAYZ01000104_gene3698	2.04e-41	157.0	COG2227@1|root,COG2227@2|Bacteria,2NQQ9@2323|unclassified Bacteria	2|Bacteria	H	Putative zinc binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
TLS2_k127_2823150_2	485913.Krac_9161	0.0007009	52.0	2E48V@1|root,32Z4P@2|Bacteria,2G7HY@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2823150_1	1122239.AULS01000001_gene1642	3.41e-61	224.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4FN0E@85023|Microbacteriaceae	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
TLS2_k127_2823150_0	383372.Rcas_3724	3.616e-136	440.0	COG0214@1|root,COG0214@2|Bacteria,2G5MW@200795|Chloroflexi,37553@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
TLS2_k127_283672_3	204669.Acid345_0715	1.627e-51	186.0	COG0292@1|root,COG0292@2|Bacteria,3Y4SW@57723|Acidobacteria,2JJJ2@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
TLS2_k127_283672_5	204669.Acid345_0714	5.89e-22	96.0	COG0291@1|root,COG0291@2|Bacteria,3Y5GU@57723|Acidobacteria,2JJX5@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
TLS2_k127_283672_1	204669.Acid345_0713	6.3e-93	306.0	COG0290@1|root,COG0290@2|Bacteria,3Y3VP@57723|Acidobacteria,2JIGK@204432|Acidobacteriia	204432|Acidobacteriia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
TLS2_k127_283672_0	1267535.KB906767_gene1334	1.246e-119	400.0	COG0621@1|root,COG0621@2|Bacteria,3Y41R@57723|Acidobacteria	57723|Acidobacteria	J	Uncharacterized protein family UPF0004	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
TLS2_k127_283672_4	204669.Acid345_1210	4.848e-47	174.0	COG0745@1|root,COG0745@2|Bacteria,3Y4UP@57723|Acidobacteria,2JJIH@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_283672_2	204669.Acid345_1209	4.211e-52	187.0	2DIW1@1|root,32UBV@2|Bacteria,3Y5BC@57723|Acidobacteria,2JJSS@204432|Acidobacteriia	204432|Acidobacteriia	S	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
TLS2_k127_2852036_0	240015.ACP_2188	1.353e-109	361.0	COG0113@1|root,COG0113@2|Bacteria,3Y2VK@57723|Acidobacteria,2JIFQ@204432|Acidobacteriia	204432|Acidobacteriia	H	Delta-aminolevulinic acid dehydratase	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
TLS2_k127_2852036_2	1437425.CSEC_2446	2.824e-52	203.0	COG0596@1|root,COG0596@2|Bacteria,2JGMW@204428|Chlamydiae	204428|Chlamydiae	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2852036_1	633149.Bresu_1062	6.731e-56	205.0	COG0596@1|root,COG0596@2|Bacteria,1QXP7@1224|Proteobacteria,2UBA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_2852036_3	1267533.KB906740_gene105	5.015e-24	107.0	COG1249@1|root,COG1249@2|Bacteria,3Y2M8@57723|Acidobacteria,2JIAI@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_2880819_0	204669.Acid345_4676	0.0	2282.0	COG0085@1|root,COG0085@2|Bacteria,3Y36G@57723|Acidobacteria,2JIQM@204432|Acidobacteriia	204432|Acidobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
TLS2_k127_2880819_5	204669.Acid345_4677	3.464e-52	186.0	COG0222@1|root,COG0222@2|Bacteria,3Y50J@57723|Acidobacteria,2JJHE@204432|Acidobacteriia	204432|Acidobacteriia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
TLS2_k127_2880819_3	204669.Acid345_4678	4.994e-70	241.0	COG0244@1|root,COG0244@2|Bacteria,3Y4N2@57723|Acidobacteria,2JJ81@204432|Acidobacteriia	204432|Acidobacteriia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
TLS2_k127_2880819_1	1382359.JIAL01000001_gene2926	2.736e-116	378.0	COG0081@1|root,COG0081@2|Bacteria,3Y2HX@57723|Acidobacteria,2JITV@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
TLS2_k127_2880819_4	204669.Acid345_4680	6.582e-69	235.0	COG0080@1|root,COG0080@2|Bacteria,3Y4PQ@57723|Acidobacteria,2JJ82@204432|Acidobacteriia	204432|Acidobacteriia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
TLS2_k127_2880819_2	204669.Acid345_4681	4.252e-97	327.0	COG0250@1|root,COG0250@2|Bacteria,3Y3ZR@57723|Acidobacteria,2JHU8@204432|Acidobacteriia	204432|Acidobacteriia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
TLS2_k127_2880819_8	204669.Acid345_4682	4.888e-20	95.0	COG0690@1|root,COG0690@2|Bacteria,3Y5SC@57723|Acidobacteria,2JK2P@204432|Acidobacteriia	204432|Acidobacteriia	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
TLS2_k127_2880819_7	204669.Acid345_4683	1.755e-23	101.0	COG0267@1|root,COG0267@2|Bacteria,3Y5UB@57723|Acidobacteria,2JJXX@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal protein L33	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
TLS2_k127_2880819_6	204669.Acid345_1224	3.499e-32	125.0	COG0050@1|root,COG0050@2|Bacteria,3Y2JG@57723|Acidobacteria,2JKFY@204432|Acidobacteriia	204432|Acidobacteriia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TLS2_k127_2891226_2	204669.Acid345_4221	4.127e-115	383.0	COG0787@1|root,COG0787@2|Bacteria,3Y2U3@57723|Acidobacteria,2JI6I@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TLS2_k127_2891226_1	204669.Acid345_4223	1.336e-187	595.0	COG0305@1|root,COG0305@2|Bacteria,3Y335@57723|Acidobacteria,2JI73@204432|Acidobacteriia	204432|Acidobacteriia	L	Participates in initiation and elongation during chromosome replication	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
TLS2_k127_2891226_0	204669.Acid345_0583	2.253e-268	853.0	COG0457@1|root,COG2199@1|root,COG2203@1|root,COG0457@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	MA20_13010	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF,HATPase_c,HisKA,Lactamase_B_2,PAS_4
TLS2_k127_2891226_3	1121920.AUAU01000009_gene1864	6.972e-48	193.0	COG0457@1|root,COG0457@2|Bacteria,3Y5YE@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2891226_4	266117.Rxyl_2043	4.71e-46	172.0	COG2154@1|root,COG2154@2|Bacteria,2HPFQ@201174|Actinobacteria,4CQU3@84995|Rubrobacteria	84995|Rubrobacteria	H	Transcriptional coactivator pterin dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
TLS2_k127_2891226_5	1254432.SCE1572_00530	1.629e-37	153.0	COG0783@1|root,COG0783@2|Bacteria	2|Bacteria	P	Belongs to the Dps family	-	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
TLS2_k127_2891226_6	204669.Acid345_0330	0.0002217	52.0	2DC00@1|root,2ZC4V@2|Bacteria,3Y8QE@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2900693_7	330214.NIDE1528	2.221e-17	87.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,FHA,Yop-YscD_cpl
TLS2_k127_2900693_2	204669.Acid345_4328	5.145e-139	446.0	COG1250@1|root,COG1250@2|Bacteria,3Y3S5@57723|Acidobacteria,2JI6S@204432|Acidobacteriia	204432|Acidobacteriia	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_2900693_5	502025.Hoch_3876	2.332e-35	157.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42NY2@68525|delta/epsilon subdivisions,2WJKQ@28221|Deltaproteobacteria,2YXDF@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF1566,Pkinase
TLS2_k127_2900693_10	675635.Psed_5846	7.981e-05	57.0	COG4886@1|root,COG4886@2|Bacteria,2HBIA@201174|Actinobacteria	201174|Actinobacteria	S	Leucine-rich repeat (LRR) protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2900693_6	1173028.ANKO01000195_gene5954	1.903e-24	121.0	COG1017@1|root,COG1017@2|Bacteria,1G3MG@1117|Cyanobacteria,1H9R2@1150|Oscillatoriales	1117|Cyanobacteria	C	Belongs to the globin family	-	-	-	-	-	-	-	-	-	-	-	-	Globin
TLS2_k127_2900693_8	102107.XP_008230676.1	1.136e-09	70.0	KOG1565@1|root,KOG1565@2759|Eukaryota,37MB0@33090|Viridiplantae,3GFCB@35493|Streptophyta,4JKX4@91835|fabids	35493|Streptophyta	O	metalloendoproteinase 1-like	-	-	3.4.24.34	ko:K01402,ko:K07999	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PG_binding_1,Peptidase_M10
TLS2_k127_2900693_3	204669.Acid345_0804	5.732e-86	313.0	COG1194@1|root,COG1194@2|Bacteria,3Y50Y@57723|Acidobacteria,2JHYP@204432|Acidobacteriia	204432|Acidobacteriia	L	FES	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TLS2_k127_2900693_4	204669.Acid345_0805	8.746e-36	148.0	COG1225@1|root,COG1225@2|Bacteria,3Y8N3@57723|Acidobacteria	57723|Acidobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_2900693_1	251221.35211871	8.223e-187	597.0	COG3653@1|root,COG3653@2|Bacteria,1G4JB@1117|Cyanobacteria	1117|Cyanobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
TLS2_k127_2900693_0	204669.Acid345_0806	8.031e-202	644.0	COG2234@1|root,COG2234@2|Bacteria,3Y3S9@57723|Acidobacteria,2JIF0@204432|Acidobacteriia	204432|Acidobacteriia	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
TLS2_k127_2900693_9	204669.Acid345_0809	1.332e-07	55.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
TLS2_k127_2905090_1	1147.D082_25660	7.903e-09	70.0	COG2931@1|root,COG3204@1|root,COG3210@1|root,COG5184@1|root,COG2931@2|Bacteria,COG3204@2|Bacteria,COG3210@2|Bacteria,COG5184@2|Bacteria,1G5KY@1117|Cyanobacteria,1H6DE@1142|Synechocystis	1117|Cyanobacteria	QU	Cadherin repeats.	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Calx-beta,HemolysinCabind,VCBS
TLS2_k127_2905090_0	1267533.KB906735_gene4668	5.351e-33	138.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y69R@57723|Acidobacteria,2JKIQ@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
TLS2_k127_2905942_10	471852.Tcur_2642	3.531e-06	54.0	COG1366@1|root,COG1366@2|Bacteria,2GUSK@201174|Actinobacteria	201174|Actinobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
TLS2_k127_2905942_0	518766.Rmar_0629	3.925e-230	747.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,4NERT@976|Bacteroidetes,1FJ3R@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	MU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	BSP,Bac_surface_Ag,PD40
TLS2_k127_2905942_4	240015.ACP_1953	7.717e-93	319.0	COG4301@1|root,COG4301@2|Bacteria,3Y2JF@57723|Acidobacteria,2JIA5@204432|Acidobacteriia	204432|Acidobacteriia	S	Histidine-specific methyltransferase, SAM-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
TLS2_k127_2905942_1	323848.Nmul_A1924	3.082e-155	504.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2VH4V@28216|Betaproteobacteria,37448@32003|Nitrosomonadales	28216|Betaproteobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
TLS2_k127_2905942_8	234267.Acid_5139	1.508e-44	182.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
TLS2_k127_2905942_2	234267.Acid_6484	3.055e-140	462.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	macB_1	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_2905942_5	1267535.KB906767_gene2303	1.319e-66	244.0	COG0845@1|root,COG0845@2|Bacteria,3Y6E7@57723|Acidobacteria	57723|Acidobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2905942_6	1340493.JNIF01000003_gene2327	2.549e-65	245.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23,OEP
TLS2_k127_2905942_7	234267.Acid_6487	5.129e-49	192.0	COG1566@1|root,COG1566@2|Bacteria	2|Bacteria	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K02005,ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
TLS2_k127_2905942_3	234267.Acid_3964	3.877e-109	393.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y7IX@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	HAMP,Pkinase
TLS2_k127_2945213_5	204669.Acid345_4725	9.871e-71	245.0	COG0632@1|root,COG0632@2|Bacteria,3Y4KI@57723|Acidobacteria,2JJCJ@204432|Acidobacteriia	204432|Acidobacteriia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
TLS2_k127_2945213_1	204669.Acid345_4729	1.944e-186	593.0	COG0486@1|root,COG0486@2|Bacteria,3Y3QJ@57723|Acidobacteria,2JHNN@204432|Acidobacteriia	204432|Acidobacteriia	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
TLS2_k127_2945213_6	204669.Acid345_0216	5.449e-54	199.0	COG1847@1|root,COG1847@2|Bacteria,3Y52C@57723|Acidobacteria,2JJF9@204432|Acidobacteriia	204432|Acidobacteriia	S	R3H domain	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	R3H
TLS2_k127_2945213_2	204669.Acid345_0217	5.189e-185	596.0	COG0706@1|root,COG0706@2|Bacteria,3Y3TD@57723|Acidobacteria,2JI2B@204432|Acidobacteriia	204432|Acidobacteriia	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
TLS2_k127_2945213_10	411474.COPEUT_01144	4.339e-19	92.0	COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes,24QN4@186801|Clostridia	186801|Clostridia	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
TLS2_k127_2945213_8	240015.ACP_2120	1.802e-26	115.0	COG0594@1|root,COG0594@2|Bacteria,3Y5EK@57723|Acidobacteria,2JJTR@204432|Acidobacteriia	204432|Acidobacteriia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
TLS2_k127_2945213_11	204669.Acid345_0220	1.968e-17	84.0	COG0230@1|root,COG0230@2|Bacteria,3Y5HB@57723|Acidobacteria,2JJWP@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
TLS2_k127_2945213_0	1198114.AciX9_0001	7.141e-212	668.0	COG0593@1|root,COG0593@2|Bacteria,3Y2HA@57723|Acidobacteria,2JHN7@204432|Acidobacteriia	204432|Acidobacteriia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
TLS2_k127_2945213_3	204669.Acid345_0002	1.694e-175	558.0	COG0592@1|root,COG0592@2|Bacteria,3Y2WE@57723|Acidobacteria,2JI4X@204432|Acidobacteriia	204432|Acidobacteriia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
TLS2_k127_2945213_7	401053.AciPR4_0373	1.828e-27	123.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria,2JIK2@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
TLS2_k127_2945213_4	1317122.ATO12_14985	8.181e-104	349.0	COG1680@1|root,COG1680@2|Bacteria,4NI1Z@976|Bacteroidetes,1HYQF@117743|Flavobacteriia,2YGQ6@290174|Aquimarina	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471,SusF_SusE,TPR_2
TLS2_k127_2950017_12	204669.Acid345_1151	1.858e-19	91.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3NT@57723|Acidobacteria,2JIBK@204432|Acidobacteriia	204432|Acidobacteriia	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
TLS2_k127_2950017_1	204669.Acid345_2341	8.005e-168	545.0	COG0815@1|root,COG0815@2|Bacteria,3Y4FZ@57723|Acidobacteria,2JKVC@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
TLS2_k127_2950017_2	204669.Acid345_2340	5.438e-167	531.0	COG1186@1|root,COG1186@2|Bacteria,3Y2ZM@57723|Acidobacteria,2JIGW@204432|Acidobacteriia	204432|Acidobacteriia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS2_k127_2950017_6	234267.Acid_3868	4.397e-70	245.0	COG0053@1|root,COG0053@2|Bacteria,3Y5VF@57723|Acidobacteria	57723|Acidobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
TLS2_k127_2950017_9	640511.BC1002_4098	1.968e-42	169.0	COG0596@1|root,COG0596@2|Bacteria,1R9VJ@1224|Proteobacteria,2VRIS@28216|Betaproteobacteria,1K0SG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_2950017_4	204669.Acid345_2338	1.586e-86	300.0	2DMMW@1|root,32SIJ@2|Bacteria,3Y8YH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2950017_8	204669.Acid345_2337	2.158e-54	194.0	COG1832@1|root,COG1832@2|Bacteria,3Y566@57723|Acidobacteria,2JJFN@204432|Acidobacteriia	204432|Acidobacteriia	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
TLS2_k127_2950017_11	1123267.JONN01000001_gene1460	1.305e-22	101.0	COG1476@1|root,COG1476@2|Bacteria,1N6SS@1224|Proteobacteria,2UFFG@28211|Alphaproteobacteria,2K6RT@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
TLS2_k127_2950017_13	1247726.MIM_c24760	5.699e-06	56.0	2E3S2@1|root,32YPN@2|Bacteria,1NDK1@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2950017_0	204669.Acid345_2614	3.318e-217	680.0	COG2256@1|root,COG2256@2|Bacteria,3Y3F7@57723|Acidobacteria,2JIAH@204432|Acidobacteriia	204432|Acidobacteriia	L	AAA ATPase	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
TLS2_k127_2950017_3	204669.Acid345_2613	2.644e-92	314.0	COG0566@1|root,COG0566@2|Bacteria,3Y4GM@57723|Acidobacteria,2JJ7T@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS2_k127_2950017_10	880072.Desac_2180	1.647e-30	123.0	COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,42W70@68525|delta/epsilon subdivisions,2WRUT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
TLS2_k127_2950017_5	204669.Acid345_2612	1.789e-77	265.0	COG0009@1|root,COG0009@2|Bacteria,3Y43Z@57723|Acidobacteria,2JI37@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the SUA5 family	-	-	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
TLS2_k127_2950017_7	204669.Acid345_2611	4.805e-58	209.0	COG1434@1|root,COG1434@2|Bacteria,3Y4FT@57723|Acidobacteria,2JJ4K@204432|Acidobacteriia	204432|Acidobacteriia	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
TLS2_k127_2952294_5	457398.HMPREF0326_00364	4.877e-16	81.0	COG1988@1|root,COG1988@2|Bacteria,1RBHW@1224|Proteobacteria,43059@68525|delta/epsilon subdivisions,2WV8K@28221|Deltaproteobacteria,2MBS1@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	YdjM
TLS2_k127_2952294_2	204669.Acid345_0392	2.905e-28	120.0	2E3WJ@1|root,32YTR@2|Bacteria,3Y5IM@57723|Acidobacteria,2JK1J@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2952294_1	204669.Acid345_0393	1.359e-68	244.0	COG2834@1|root,COG2834@2|Bacteria,3Y51N@57723|Acidobacteria,2JJJ7@204432|Acidobacteriia	204432|Acidobacteriia	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	LolA,LolA_like
TLS2_k127_2952294_0	204669.Acid345_0395	1.792e-263	857.0	COG1629@1|root,COG4771@2|Bacteria,3Y2GB@57723|Acidobacteria,2JP02@204432|Acidobacteriia	204432|Acidobacteriia	P	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_2952294_4	1267534.KB906756_gene287	1.415e-16	86.0	COG1012@1|root,COG1012@2|Bacteria,3Y37W@57723|Acidobacteria,2JHJP@204432|Acidobacteriia	204432|Acidobacteriia	C	Delta-1-pyrroline-5-carboxylate dehydrogenase	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS2_k127_2991403_3	204669.Acid345_4628	4.978e-227	727.0	COG3276@1|root,COG3276@2|Bacteria,3Y6R2@57723|Acidobacteria,2JKPY@204432|Acidobacteriia	204432|Acidobacteriia	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,SelB-wing_3
TLS2_k127_2991403_23	1198114.AciX9_0836	3.791e-05	57.0	291D9@1|root,2ZP04@2|Bacteria,3Y8Y7@57723|Acidobacteria,2JNPP@204432|Acidobacteriia	204432|Acidobacteriia	S	Putative prokaryotic signal transducing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
TLS2_k127_2991403_22	1177154.Y5S_03009	3.271e-10	72.0	COG2706@1|root,COG2706@2|Bacteria,1NB7P@1224|Proteobacteria,1SCSF@1236|Gammaproteobacteria,1XQE5@135619|Oceanospirillales	135619|Oceanospirillales	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS2_k127_2991403_0	204669.Acid345_4622	0.0	1105.0	COG0046@1|root,COG0046@2|Bacteria,3Y30N@57723|Acidobacteria,2JHYK@204432|Acidobacteriia	204432|Acidobacteriia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_2991403_1	204669.Acid345_4621	2.083e-244	761.0	COG0034@1|root,COG0034@2|Bacteria,3Y3RG@57723|Acidobacteria,2JHXM@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
TLS2_k127_2991403_17	1089550.ATTH01000001_gene1052	3.564e-43	169.0	COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1FJR9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_2991403_19	1144275.COCOR_00040	1.621e-34	140.0	291YA@1|root,2ZPHV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2991403_11	1173021.ALWA01000012_gene1271	6.425e-100	333.0	COG0491@1|root,COG1141@1|root,COG0491@2|Bacteria,COG1141@2|Bacteria,1G3D1@1117|Cyanobacteria	1117|Cyanobacteria	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13
TLS2_k127_2991403_6	204669.Acid345_0163	3.895e-136	447.0	COG0475@1|root,COG0475@2|Bacteria,3Y5ES@57723|Acidobacteria,2JJSE@204432|Acidobacteriia	204432|Acidobacteriia	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS2_k127_2991403_10	574087.Acear_1816	3.968e-107	364.0	COG0166@1|root,COG0166@2|Bacteria,1TP29@1239|Firmicutes,2487A@186801|Clostridia,3WA5V@53433|Halanaerobiales	186801|Clostridia	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
TLS2_k127_2991403_21	204669.Acid345_0161	7.909e-27	129.0	COG1714@1|root,COG1714@2|Bacteria,3Y5I9@57723|Acidobacteria,2JJVV@204432|Acidobacteriia	204432|Acidobacteriia	S	pfam rdd	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS2_k127_2991403_2	204669.Acid345_0160	5.264e-239	764.0	COG1452@1|root,COG1452@2|Bacteria,3Y37B@57723|Acidobacteria,2JHPP@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Organic solvent tolerance protein	-	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA_C
TLS2_k127_2991403_13	204669.Acid345_0158	7.785e-72	253.0	COG1651@1|root,COG1651@2|Bacteria,3Y2G9@57723|Acidobacteria,2JIKS@204432|Acidobacteriia	204432|Acidobacteriia	O	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
TLS2_k127_2991403_8	204669.Acid345_0157	2.608e-121	399.0	COG0760@1|root,COG0760@2|Bacteria,3Y42Z@57723|Acidobacteria,2JHQ4@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N_3
TLS2_k127_2991403_9	204669.Acid345_2224	5.636e-108	359.0	COG0598@1|root,COG0598@2|Bacteria,3Y4BT@57723|Acidobacteria,2JJ37@204432|Acidobacteriia	204432|Acidobacteriia	P	CorA-like Mg2+ transporter protein	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
TLS2_k127_2991403_14	204669.Acid345_0195	1.357e-57	205.0	2CBQR@1|root,32RTV@2|Bacteria,3Y57Z@57723|Acidobacteria,2JJRD@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2991403_7	1382359.JIAL01000001_gene1428	1.321e-131	427.0	COG0031@1|root,COG0031@2|Bacteria,3Y39M@57723|Acidobacteria,2JIQR@204432|Acidobacteriia	204432|Acidobacteriia	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_2991403_15	1382359.JIAL01000001_gene1429	2.014e-53	193.0	COG1310@1|root,COG1310@2|Bacteria,3Y4PH@57723|Acidobacteria,2JJ8J@204432|Acidobacteriia	204432|Acidobacteriia	S	Mov34 MPN PAD-1	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
TLS2_k127_2991403_20	1267533.KB906734_gene3944	2.813e-33	131.0	COG1977@1|root,COG1977@2|Bacteria,3Y546@57723|Acidobacteria,2JJNC@204432|Acidobacteriia	204432|Acidobacteriia	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS2_k127_2991403_5	1382359.JIAL01000001_gene1431	6.93e-190	600.0	COG0476@1|root,COG0476@2|Bacteria,3Y3IF@57723|Acidobacteria,2JIPC@204432|Acidobacteriia	204432|Acidobacteriia	HP	PFAM UBA THIF-type NAD FAD binding	-	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
TLS2_k127_2991403_18	497964.CfE428DRAFT_3867	2.684e-38	153.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	2.7.7.80,2.8.1.11	ko:K03636,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiS
TLS2_k127_2991403_4	1267534.KB906756_gene86	6.27e-215	679.0	COG4447@1|root,COG4447@2|Bacteria,3Y3TM@57723|Acidobacteria,2JHSZ@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
TLS2_k127_2991403_16	1205680.CAKO01000029_gene5240	3.516e-49	181.0	COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,2UC7A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	RNA signal recognition particle 4.5S RNA	-	-	-	-	-	-	-	-	-	-	-	-	DUF1428
TLS2_k127_2991403_12	204669.Acid345_4734	2.663e-94	314.0	28PH7@1|root,2ZC7R@2|Bacteria,3Y4CI@57723|Acidobacteria,2JJ15@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3010663_5	204669.Acid345_0104	1.528e-46	171.0	COG1610@1|root,COG1610@2|Bacteria,3Y4VF@57723|Acidobacteria,2JJJH@204432|Acidobacteriia	204432|Acidobacteriia	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS2_k127_3010663_1	204669.Acid345_0114	3.958e-155	499.0	COG0075@1|root,COG0075@2|Bacteria,3Y3I6@57723|Acidobacteria,2JIIW@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase, class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_3010663_0	204669.Acid345_0115	4.855e-186	596.0	COG1052@1|root,COG1052@2|Bacteria,3Y2MD@57723|Acidobacteria,2JHYI@204432|Acidobacteriia	204432|Acidobacteriia	E	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
TLS2_k127_3010663_6	314345.SPV1_10541	9.707e-07	61.0	29WVE@1|root,30IH2@2|Bacteria,1NHMG@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3010663_2	204669.Acid345_0116	8.564e-114	378.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,3Y4AH@57723|Acidobacteria,2JJ4R@204432|Acidobacteriia	204432|Acidobacteriia	K	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
TLS2_k127_3010663_4	204669.Acid345_0117	2.563e-50	185.0	COG0742@1|root,COG0742@2|Bacteria,3Y4K0@57723|Acidobacteria,2JJDW@204432|Acidobacteriia	204432|Acidobacteriia	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
TLS2_k127_3042539_7	1267535.KB906767_gene2292	2.087e-137	448.0	COG1132@1|root,COG1132@2|Bacteria,3Y2ZR@57723|Acidobacteria,2JHJA@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter, transmembrane	-	-	-	ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
TLS2_k127_3042539_8	204669.Acid345_2535	5.016e-136	446.0	COG0763@1|root,COG0763@2|Bacteria,3Y34H@57723|Acidobacteria,2JID9@204432|Acidobacteriia	204432|Acidobacteriia	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
TLS2_k127_3042539_2	204669.Acid345_2536	2.826e-250	791.0	COG0308@1|root,COG0457@1|root,COG0308@2|Bacteria,COG0457@2|Bacteria,3Y3C5@57723|Acidobacteria,2JI5M@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1,TPR_11,TPR_16
TLS2_k127_3042539_9	204669.Acid345_2755	1.245e-128	426.0	COG1565@1|root,COG1565@2|Bacteria,3Y583@57723|Acidobacteria,2JNKN@204432|Acidobacteriia	204432|Acidobacteriia	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
TLS2_k127_3042539_19	204669.Acid345_2756	3.887e-38	146.0	2C8EQ@1|root,3497J@2|Bacteria,3Y8QF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3042539_5	204669.Acid345_2757	2.949e-149	484.0	COG0577@1|root,COG0577@2|Bacteria,3Y3X9@57723|Acidobacteria,2JHKJ@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_3042539_6	204669.Acid345_2758	1.989e-147	478.0	COG0577@1|root,COG0577@2|Bacteria,3Y2IG@57723|Acidobacteria,2JHUY@204432|Acidobacteriia	2|Bacteria	V	MacB-like periplasmic core domain	macB_3	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_3042539_20	1499967.BAYZ01000157_gene582	5.279e-14	84.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	GGDEF,HATPase_c,HisKA,cNMP_binding
TLS2_k127_3042539_18	251229.Chro_2175	3.379e-51	196.0	COG0580@1|root,COG0580@2|Bacteria,1G3MJ@1117|Cyanobacteria	2|Bacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	glpF	-	-	ko:K02440,ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.2	-	-	MIP
TLS2_k127_3042539_11	234267.Acid_4318	6.614e-119	401.0	COG3193@1|root,COG3193@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
TLS2_k127_3042539_4	234267.Acid_4316	4.577e-161	532.0	COG3827@1|root,COG3827@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K11891,ko:K16091	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	1.B.14.1.14,3.A.23.1	-	-	Plug,TonB_dep_Rec
TLS2_k127_3042539_0	234267.Acid_4317	0.0	1386.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	LVIVD,SBP56
TLS2_k127_3042539_14	351160.RCIX1128	2.599e-91	312.0	COG1063@1|root,arCOG01459@2157|Archaea,2XT9P@28890|Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway	gdh	GO:0000166,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005515,GO:0005534,GO:0005536,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006012,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019318,GO:0019320,GO:0019388,GO:0019595,GO:0022607,GO:0030246,GO:0033498,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046430,GO:0046872,GO:0046914,GO:0046983,GO:0047910,GO:0047936,GO:0048029,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051262,GO:0051287,GO:0055114,GO:0065003,GO:0070401,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.1.1.140,1.1.1.359,1.1.1.360	ko:K00068,ko:K18124,ko:K18125	ko00030,ko00051,ko00052,ko01100,ko01110,ko01130,ko01200,map00030,map00051,map00052,map01100,map01110,map01130,map01200	-	R01096,R05607,R07147,R08544	RC00066,RC00085	ko00000,ko00001,ko01000	-	-	-	ADH_N,Glu_dehyd_C
TLS2_k127_3042539_17	886293.Sinac_4968	2.774e-54	208.0	COG1716@1|root,COG1716@2|Bacteria,2IZYG@203682|Planctomycetes	203682|Planctomycetes	C	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
TLS2_k127_3042539_16	234267.Acid_4311	2.047e-61	223.0	29W19@1|root,30HJP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3042539_3	575540.Isop_3158	3.874e-191	629.0	COG0664@1|root,COG1142@1|root,COG3383@1|root,COG0664@2|Bacteria,COG1142@2|Bacteria,COG3383@2|Bacteria,2IX98@203682|Planctomycetes	203682|Planctomycetes	CT	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4,cNMP_binding
TLS2_k127_3042539_10	760568.Desku_2308	3.086e-119	404.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,260R6@186807|Peptococcaceae	186801|Clostridia	C	NADH dehydrogenase	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
TLS2_k127_3042539_15	234267.Acid_4315	5.799e-74	265.0	2BF9B@1|root,32926@2|Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
TLS2_k127_3042539_1	502025.Hoch_5404	0.0	1232.0	COG1452@1|root,COG1452@2|Bacteria,1QW3G@1224|Proteobacteria,43CZ5@68525|delta/epsilon subdivisions,2X87D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3042539_13	1121430.JMLG01000002_gene1080	4.646e-102	344.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia,260DQ@186807|Peptococcaceae	186801|Clostridia	I	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_3042539_21	240015.ACP_0912	1.872e-11	67.0	2C8ER@1|root,33N58@2|Bacteria,3Y60H@57723|Acidobacteria,2JK3D@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3042539_12	1150398.JIBJ01000003_gene1714	1.671e-102	344.0	COG0366@1|root,COG0366@2|Bacteria,2GN52@201174|Actinobacteria	201174|Actinobacteria	G	Alpha amylase catalytic	amyA	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
TLS2_k127_3048613_0	1123393.KB891316_gene2018	2.361e-137	441.0	28HGI@1|root,2Z7SC@2|Bacteria,1MWKC@1224|Proteobacteria,2VP5Q@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3048613_1	1038866.KB902800_gene6833	6.324e-56	205.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria,3JU44@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3061295_0	234267.Acid_0959	3.235e-173	554.0	COG0514@1|root,COG0514@2|Bacteria,3Y2KM@57723|Acidobacteria	57723|Acidobacteria	L	RecQ zinc-binding	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RecQ_Zn_bind
TLS2_k127_3062061_15	204669.Acid345_0039	3.222e-73	250.0	COG0491@1|root,COG0491@2|Bacteria,3Y3M4@57723|Acidobacteria,2JI7X@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_3062061_20	1267533.KB906736_gene910	8.089e-51	186.0	COG4762@1|root,COG4762@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF1990)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1990
TLS2_k127_3062061_5	1382359.JIAL01000001_gene1611	3.388e-151	485.0	COG0042@1|root,COG0042@2|Bacteria,3Y3XE@57723|Acidobacteria,2JI1U@204432|Acidobacteriia	204432|Acidobacteriia	J	synthase	-	-	-	-	-	-	-	-	-	-	-	-	Dus
TLS2_k127_3062061_23	240015.ACP_3082	5.533e-33	131.0	COG0254@1|root,COG0254@2|Bacteria,3Y5BI@57723|Acidobacteria,2JP2A@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
TLS2_k127_3062061_3	251221.35211765	8.899e-178	585.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_3062061_22	204669.Acid345_4704	2.2e-35	140.0	COG0776@1|root,COG0776@2|Bacteria,3Y93V@57723|Acidobacteria	57723|Acidobacteria	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_3062061_0	204669.Acid345_4705	0.0	1041.0	COG1449@1|root,COG1449@2|Bacteria,3Y2JJ@57723|Acidobacteria,2JHW6@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
TLS2_k127_3062061_25	1121289.JHVL01000055_gene554	3.656e-11	71.0	COG1714@1|root,COG1714@2|Bacteria,1VIRT@1239|Firmicutes,24TSH@186801|Clostridia,36N4N@31979|Clostridiaceae	186801|Clostridia	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS2_k127_3062061_2	309801.trd_0496	1.065e-191	604.0	COG2513@1|root,COG2513@2|Bacteria,2GAB6@200795|Chloroflexi,27YTJ@189775|Thermomicrobia	189775|Thermomicrobia	G	Phosphoenolpyruvate phosphomutase	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
TLS2_k127_3062061_1	204669.Acid345_4707	1.557e-232	731.0	COG2225@1|root,COG2225@2|Bacteria,3Y4MK@57723|Acidobacteria,2JKQY@204432|Acidobacteriia	204432|Acidobacteriia	C	Malate synthase	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
TLS2_k127_3062061_21	204669.Acid345_0084	5.803e-37	150.0	COG0745@1|root,COG0745@2|Bacteria	204669.Acid345_0084|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3062061_9	204669.Acid345_0085	1.241e-125	408.0	COG0774@1|root,COG0774@2|Bacteria,3Y40I@57723|Acidobacteria,2JI1R@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
TLS2_k127_3062061_19	204669.Acid345_0123	4.358e-54	203.0	2A6XZ@1|root,30VSX@2|Bacteria,3Y4RH@57723|Acidobacteria,2JJCB@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3062061_11	204669.Acid345_0122	6.137e-96	321.0	COG1028@1|root,COG1028@2|Bacteria,3Y3FQ@57723|Acidobacteria,2JHPU@204432|Acidobacteriia	204432|Acidobacteriia	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_3062061_16	639030.JHVA01000001_gene2517	2.598e-64	230.0	COG2071@1|root,COG2071@2|Bacteria,3Y4PA@57723|Acidobacteria,2JJ8I@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
TLS2_k127_3062061_14	204669.Acid345_0120	3.182e-89	302.0	COG0204@1|root,COG0204@2|Bacteria,3Y4EM@57723|Acidobacteria,2JJ6E@204432|Acidobacteriia	204432|Acidobacteriia	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_3062061_6	204669.Acid345_0119	5.877e-147	478.0	COG0285@1|root,COG0285@2|Bacteria,3Y3ZA@57723|Acidobacteria,2JI7I@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM Mur ligase	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
TLS2_k127_3062061_8	204669.Acid345_4701	3.955e-134	432.0	COG0777@1|root,COG0777@2|Bacteria,3Y2U9@57723|Acidobacteria,2JI81@204432|Acidobacteriia	204432|Acidobacteriia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_3062061_13	204669.Acid345_4702	1.915e-94	323.0	COG2109@1|root,COG2109@2|Bacteria,3Y4DE@57723|Acidobacteria,2JJ2Y@204432|Acidobacteriia	204432|Acidobacteriia	H	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
TLS2_k127_3062061_18	204669.Acid345_0277	3.204e-55	202.0	COG4856@1|root,COG4856@2|Bacteria,3Y8QK@57723|Acidobacteria	57723|Acidobacteria	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
TLS2_k127_3062061_10	204669.Acid345_0278	9.893e-103	342.0	COG1624@1|root,COG1624@2|Bacteria,3Y7NU@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	-	-	-	-	-	-	-	-	-	-	DisA_N
TLS2_k127_3062061_4	204669.Acid345_0279	9.682e-174	557.0	COG1570@1|root,COG1570@2|Bacteria,3Y3DP@57723|Acidobacteria,2JIQN@204432|Acidobacteriia	204432|Acidobacteriia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TLS2_k127_3062061_17	1288494.EBAPG3_16310	2.11e-61	220.0	2CAM1@1|root,301FE@2|Bacteria,1RJ36@1224|Proteobacteria,2VR84@28216|Betaproteobacteria,372P3@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase
TLS2_k127_3062061_27	1894.JOER01000056_gene3357	7.272e-09	66.0	COG3832@1|root,COG3832@2|Bacteria,2IFNX@201174|Actinobacteria	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_3062061_12	1210884.HG799464_gene11118	4.81e-95	337.0	COG2520@1|root,COG2520@2|Bacteria,2J4W5@203682|Planctomycetes	203682|Planctomycetes	J	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
TLS2_k127_3062061_26	33898.JRHJ01000039_gene4449	3.71e-11	69.0	COG5485@1|root,COG5485@2|Bacteria,2GJYB@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
TLS2_k127_3062061_7	1407650.BAUB01000004_gene1079	2.566e-140	470.0	COG2804@1|root,COG2804@2|Bacteria,1G03J@1117|Cyanobacteria,1GZBY@1129|Synechococcus	1117|Cyanobacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
TLS2_k127_3074373_2	204669.Acid345_4473	1.999e-15	76.0	COG3872@1|root,COG3872@2|Bacteria,3Y66K@57723|Acidobacteria,2JKRW@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1385)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
TLS2_k127_3074373_0	204669.Acid345_4472	1.5e-179	568.0	COG0216@1|root,COG0216@2|Bacteria,3Y2N9@57723|Acidobacteria,2JHYH@204432|Acidobacteriia	204432|Acidobacteriia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS2_k127_3074373_3	240015.ACP_0488	2.669e-07	60.0	COG0810@1|root,COG0810@2|Bacteria,3Y4BU@57723|Acidobacteria,2JJ3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
TLS2_k127_3074373_1	204669.Acid345_4471	7.817e-55	197.0	COG2890@1|root,COG2890@2|Bacteria,3Y4KU@57723|Acidobacteria,2JJCF@204432|Acidobacteriia	204432|Acidobacteriia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
TLS2_k127_309317_5	1267534.KB906755_gene4343	1.165e-09	68.0	COG2304@1|root,COG2304@2|Bacteria,3Y3QQ@57723|Acidobacteria,2JHV1@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
TLS2_k127_309317_3	204669.Acid345_2686	3.09e-154	493.0	COG0492@1|root,COG0492@2|Bacteria,3Y2NX@57723|Acidobacteria,2JHZ4@204432|Acidobacteriia	204432|Acidobacteriia	C	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_3
TLS2_k127_309317_0	204669.Acid345_2689	4.746e-234	733.0	COG1027@1|root,COG1027@2|Bacteria,3Y3XS@57723|Acidobacteria,2JHYF@204432|Acidobacteriia	204432|Acidobacteriia	E	Fumarase C C-terminus	-	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
TLS2_k127_309317_2	278963.ATWD01000001_gene1646	1.344e-159	511.0	COG0332@1|root,COG0332@2|Bacteria,3Y2Z5@57723|Acidobacteria,2JIAW@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
TLS2_k127_309317_1	204669.Acid345_2146	2.901e-192	623.0	COG1305@1|root,COG1305@2|Bacteria,3Y5BT@57723|Acidobacteria	57723|Acidobacteria	E	Domain of unknown function (DUF3488)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,DUF4129,Transglut_core
TLS2_k127_309317_4	204669.Acid345_1284	2.207e-21	96.0	COG1695@1|root,COG1695@2|Bacteria,3Y5C5@57723|Acidobacteria,2JNCX@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_3105600_0	204669.Acid345_4366	1.045e-84	290.0	COG4373@1|root,COG4373@2|Bacteria,3Y318@57723|Acidobacteria,2JIZZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Mu-like prophage FluMu protein gp28	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6C
TLS2_k127_3105600_3	1408813.AYMG01000046_gene4793	0.0007271	52.0	COG3210@1|root,COG3291@1|root,COG4935@1|root,COG3210@2|Bacteria,COG3291@2|Bacteria,COG4935@2|Bacteria,4NDZC@976|Bacteroidetes,1IRNR@117747|Sphingobacteriia	976|Bacteroidetes	U	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11
TLS2_k127_3105600_4	1132509.C447_01760	0.0007406	53.0	COG3420@1|root,arCOG02519@2157|Archaea,2Y81I@28890|Euryarchaeota,2412P@183963|Halobacteria	183963|Halobacteria	P	Pectate lyase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectate_lyase_3
TLS2_k127_3105600_2	204669.Acid345_4368	1.4e-38	168.0	2EKZZ@1|root,33EPG@2|Bacteria,3Y5U9@57723|Acidobacteria,2JKFN@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Lipase_GDSL_2
TLS2_k127_3105600_1	204669.Acid345_4369	4.54e-61	213.0	COG2453@1|root,COG2453@2|Bacteria	2|Bacteria	T	phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DSPc
TLS2_k127_3146967_0	1047013.AQSP01000105_gene1436	1.277e-88	302.0	COG2421@1|root,COG2421@2|Bacteria,2NR72@2323|unclassified Bacteria	2|Bacteria	C	Acetamidase/Formamidase family	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
TLS2_k127_3146967_1	926566.Terro_1287	1.335e-46	186.0	2DBAV@1|root,2Z84I@2|Bacteria,3Y2PF@57723|Acidobacteria,2JIIF@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3157658_0	682795.AciX8_1501	1.54e-179	570.0	COG0399@1|root,COG0399@2|Bacteria,3Y64F@57723|Acidobacteria,2JP3E@204432|Acidobacteriia	204432|Acidobacteriia	H	Beta-eliminating lyase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_3157658_5	1322246.BN4_12167	3.17e-53	204.0	COG0546@1|root,COG0546@2|Bacteria,1QURP@1224|Proteobacteria	1224|Proteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
TLS2_k127_3157658_1	204669.Acid345_3820	3.906e-116	383.0	COG0151@1|root,COG0151@2|Bacteria	2|Bacteria	F	phosphoribosylamine-glycine ligase activity	-	-	4.3.2.1,6.3.5.5	ko:K01755,ko:K01955	ko00220,ko00240,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00240,map00250,map01100,map01110,map01130,map01230	M00029,M00051,M00844,M00845	R00256,R00575,R01086,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00445,RC00447,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ATP-grasp_3,ATP-grasp_4,ATPgrasp_Ter
TLS2_k127_3157658_4	649638.Trad_1270	4.561e-61	226.0	COG2148@1|root,COG2148@2|Bacteria,1WJRF@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Bacterial sugar transferase	-	-	2.7.8.40	ko:K21303	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	-	-	Bac_transf
TLS2_k127_3157658_2	204669.Acid345_2279	1.775e-63	237.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	HemolysinCabind,Metallophos
TLS2_k127_3157658_3	204669.Acid345_2279	7.152e-62	232.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	HemolysinCabind,Metallophos
TLS2_k127_3162123_0	1382359.JIAL01000001_gene994	4.801e-223	705.0	COG0154@1|root,COG0154@2|Bacteria,3Y3E5@57723|Acidobacteria,2JISE@204432|Acidobacteriia	204432|Acidobacteriia	J	PFAM Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
TLS2_k127_3162123_1	1415756.JQMY01000001_gene3604	4.09e-12	78.0	COG3637@1|root,COG3637@2|Bacteria,1RBBG@1224|Proteobacteria,2U5ED@28211|Alphaproteobacteria,2PE89@252301|Oceanicola	28211|Alphaproteobacteria	M	Outer membrane protein beta-barrel domain	lpxQ	-	-	ko:K12980	-	-	-	-	ko00000,ko01005	-	-	-	OMP_b-brl
TLS2_k127_3162123_2	1267533.KB906733_gene2891	1.8e-05	57.0	COG0860@1|root,COG0860@2|Bacteria,3Y3M0@57723|Acidobacteria,2JI9V@204432|Acidobacteriia	204432|Acidobacteriia	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
TLS2_k127_3202722_2	1267533.KB906734_gene3683	6.925e-39	154.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_3202722_1	204669.Acid345_3321	1.046e-166	541.0	COG3485@1|root,COG3485@2|Bacteria,3Y44E@57723|Acidobacteria,2JIGS@204432|Acidobacteriia	204432|Acidobacteriia	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_3202722_0	1267533.KB906735_gene4507	4.234e-214	681.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria,2JIG4@204432|Acidobacteriia	204432|Acidobacteriia	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3218857_4	1267533.KB906734_gene4266	1.209e-13	74.0	COG0405@1|root,COG0405@2|Bacteria,3Y2N0@57723|Acidobacteria,2JHK2@204432|Acidobacteriia	204432|Acidobacteriia	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_3218857_1	204669.Acid345_4415	8.369e-124	407.0	COG0265@1|root,COG0265@2|Bacteria,3Y3HE@57723|Acidobacteria,2JHN5@204432|Acidobacteriia	204432|Acidobacteriia	O	peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_3218857_2	204669.Acid345_4423	1.029e-61	219.0	COG0237@1|root,COG0237@2|Bacteria,3Y4R2@57723|Acidobacteria,2JJAY@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
TLS2_k127_3218857_0	204669.Acid345_4424	5.705e-138	446.0	COG0190@1|root,COG0190@2|Bacteria,3Y2IN@57723|Acidobacteria,2JIT2@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
TLS2_k127_3218857_6	234267.Acid_2357	1.268e-09	64.0	COG2835@1|root,COG2835@2|Bacteria,3Y8VE@57723|Acidobacteria	57723|Acidobacteria	S	Trm112p-like protein	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
TLS2_k127_3218857_3	240015.ACP_1978	4.522e-14	79.0	2ECNX@1|root,336KP@2|Bacteria,3Y5M6@57723|Acidobacteria,2JJZW@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3218857_5	204669.Acid345_2223	1.167e-11	72.0	COG0629@1|root,COG0629@2|Bacteria,3Y4D2@57723|Acidobacteria,2JJ18@204432|Acidobacteriia	204432|Acidobacteriia	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_3246725_16	234267.Acid_5685	3.859e-30	119.0	COG1143@1|root,COG1143@2|Bacteria,3Y529@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
TLS2_k127_3246725_5	204669.Acid345_1939	8.8e-141	456.0	COG2957@1|root,COG2957@2|Bacteria,3Y2W5@57723|Acidobacteria,2JIKF@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the agmatine deiminase family	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
TLS2_k127_3246725_4	240015.ACP_1745	6.659e-159	505.0	COG0388@1|root,COG0388@2|Bacteria,3Y2T9@57723|Acidobacteria,2JI2H@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
TLS2_k127_3246725_3	204669.Acid345_3440	9.794e-164	526.0	COG0019@1|root,COG0019@2|Bacteria,3Y2W4@57723|Acidobacteria,2JI3I@204432|Acidobacteriia	204432|Acidobacteriia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS2_k127_3246725_1	204669.Acid345_3439	4.327e-225	728.0	COG1956@1|root,COG2203@1|root,COG2208@1|root,COG1956@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y358@57723|Acidobacteria,2JIID@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,SpoIIE
TLS2_k127_3246725_11	204669.Acid345_2634	4.721e-98	330.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	yicL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_3246725_17	240015.ACP_3351	5.142e-20	96.0	COG0695@1|root,COG0695@2|Bacteria,3Y8TH@57723|Acidobacteria,2JNX4@204432|Acidobacteriia	204432|Acidobacteriia	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
TLS2_k127_3246725_6	555779.Dthio_PD1047	4.639e-140	466.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,42M0Z@68525|delta/epsilon subdivisions,2WK36@28221|Deltaproteobacteria,2M8NG@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Bile acid sodium symporter	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
TLS2_k127_3246725_15	204669.Acid345_2244	2.953e-40	155.0	COG1765@1|root,COG1765@2|Bacteria,3Y563@57723|Acidobacteria,2JJUX@204432|Acidobacteriia	204432|Acidobacteriia	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
TLS2_k127_3246725_14	583355.Caka_1297	8.903e-78	275.0	COG0053@1|root,COG0053@2|Bacteria,46SPJ@74201|Verrucomicrobia,3K7YF@414999|Opitutae	414999|Opitutae	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TLS2_k127_3246725_10	204669.Acid345_2248	8.336e-99	333.0	COG0500@1|root,COG2226@2|Bacteria,3Y44I@57723|Acidobacteria,2JHWJ@204432|Acidobacteriia	204432|Acidobacteriia	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS2_k127_3246725_7	204669.Acid345_2249	2.161e-131	428.0	COG0337@1|root,COG0337@2|Bacteria,3Y2T4@57723|Acidobacteria,2JI0C@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
TLS2_k127_3246725_2	204669.Acid345_2250	4.667e-213	675.0	COG0029@1|root,COG0029@2|Bacteria,3Y39F@57723|Acidobacteria,2JHJ5@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_3246725_8	1379698.RBG1_1C00001G0467	4.163e-111	367.0	COG0861@1|root,COG0861@2|Bacteria,2NNXY@2323|unclassified Bacteria	2|Bacteria	P	Integral membrane protein TerC family	terC	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
TLS2_k127_3246725_13	204669.Acid345_2673	3.162e-95	325.0	COG2146@1|root,COG4244@1|root,COG2146@2|Bacteria,COG4244@2|Bacteria,3Y9G1@57723|Acidobacteria,2JNVM@204432|Acidobacteriia	204432|Acidobacteriia	C	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
TLS2_k127_3246725_18	861299.J421_5671	3.253e-19	94.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,T4_deiodinase
TLS2_k127_3246725_21	1267533.KB906734_gene3938	9.104e-13	69.0	COG2331@1|root,COG2331@2|Bacteria	2|Bacteria	P	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TLS2_k127_3246725_12	1382359.JIAL01000001_gene1834	2.298e-95	332.0	COG2234@1|root,COG2234@2|Bacteria,3Y406@57723|Acidobacteria,2JIRZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_3246725_9	204669.Acid345_2680	8.435e-105	346.0	COG0805@1|root,COG0805@2|Bacteria,3Y3UC@57723|Acidobacteria,2JISU@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
TLS2_k127_3246725_19	204669.Acid345_2679	1.286e-15	81.0	COG1826@1|root,COG1826@2|Bacteria,3Y5G2@57723|Acidobacteria,2JJY5@204432|Acidobacteriia	204432|Acidobacteriia	U	mttA/Hcf106 family	-	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS2_k127_3246725_0	204669.Acid345_2676	3.267e-256	801.0	COG0793@1|root,COG0793@2|Bacteria,3Y3KP@57723|Acidobacteria,2JHNE@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
TLS2_k127_3256222_6	643867.Ftrac_2916	1.875e-10	64.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,4PM8I@976|Bacteroidetes,47KK7@768503|Cytophagia	976|Bacteroidetes	QU	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
TLS2_k127_3256222_0	1382359.JIAL01000001_gene438	3.259e-305	947.0	COG1138@1|root,COG1138@2|Bacteria,3Y40N@57723|Acidobacteria,2JHQR@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM Cytochrome c assembly protein	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
TLS2_k127_3256222_4	204669.Acid345_3206	1.292e-36	143.0	COG3088@1|root,COG3088@2|Bacteria,3Y4YV@57723|Acidobacteria,2JJM2@204432|Acidobacteriia	204432|Acidobacteriia	O	subunit of a heme lyase	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
TLS2_k127_3256222_5	1382359.JIAL01000001_gene440	7.996e-17	91.0	2EFR0@1|root,339H2@2|Bacteria,3Y5M9@57723|Acidobacteria,2JJPZ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3256222_2	1382359.JIAL01000001_gene441	9.862e-102	346.0	28K54@1|root,2Z9TW@2|Bacteria,3Y3Z7@57723|Acidobacteria,2JHS9@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3256222_7	1121957.ATVL01000006_gene2761	8.57e-10	65.0	2DQ2S@1|root,334IA@2|Bacteria,4NYGH@976|Bacteroidetes,47X2A@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3256222_1	204669.Acid345_2311	8.546e-114	383.0	2DKFZ@1|root,309D6@2|Bacteria,3Y5NS@57723|Acidobacteria,2JM02@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
TLS2_k127_3256222_3	1267533.KB906737_gene1578	7.624e-70	246.0	COG0501@1|root,COG0501@2|Bacteria,3Y3EZ@57723|Acidobacteria,2JIIZ@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS2_k127_326210_2	1254432.SCE1572_11285	1.419e-142	472.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,42PQI@68525|delta/epsilon subdivisions,2WKZR@28221|Deltaproteobacteria,2YUAG@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh_C,ATP-grasp
TLS2_k127_326210_6	1382359.JIAL01000001_gene1183	3.132e-68	235.0	COG0041@1|root,COG0041@2|Bacteria,3Y4MB@57723|Acidobacteria,2JJ9S@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
TLS2_k127_326210_1	56110.Oscil6304_1573	2.166e-147	481.0	COG2270@1|root,COG2270@2|Bacteria,1G3YB@1117|Cyanobacteria,1HA0N@1150|Oscillatoriales	1117|Cyanobacteria	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
TLS2_k127_326210_4	68570.DC74_387	5.91e-108	372.0	COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria	201174|Actinobacteria	IQ	Peptidase S15	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
TLS2_k127_326210_3	204669.Acid345_3905	9.093e-142	464.0	COG0161@1|root,COG0161@2|Bacteria,3Y99B@57723|Acidobacteria,2JP5I@204432|Acidobacteriia	204432|Acidobacteriia	H	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
TLS2_k127_326210_0	204669.Acid345_2823	1.1e-284	894.0	COG2234@1|root,COG2234@2|Bacteria,3Y33F@57723|Acidobacteria,2JI7G@204432|Acidobacteriia	2|Bacteria	S	Transferrin receptor-like dimerisation domain	-	-	3.4.17.21	ko:K01301	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28,TFR_dimer
TLS2_k127_326210_8	483219.LILAB_15170	3.914e-42	158.0	COG4539@1|root,COG4539@2|Bacteria,1NXWT@1224|Proteobacteria,4384M@68525|delta/epsilon subdivisions,2X9XD@28221|Deltaproteobacteria,2YVQP@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF962)	-	-	-	-	-	-	-	-	-	-	-	-	DUF962
TLS2_k127_326210_9	204669.Acid345_3964	2.064e-35	136.0	COG2924@1|root,COG2924@2|Bacteria,3Y4ZS@57723|Acidobacteria,2JJEE@204432|Acidobacteriia	204432|Acidobacteriia	CO	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
TLS2_k127_326210_10	1265505.ATUG01000002_gene1414	2.721e-35	148.0	COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,42RSB@68525|delta/epsilon subdivisions,2X6V6@28221|Deltaproteobacteria,2MMG6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS2_k127_326210_5	483219.LILAB_01140	5.851e-75	273.0	COG0204@1|root,COG0236@1|root,COG1022@1|root,COG3320@1|root,COG0204@2|Bacteria,COG0236@2|Bacteria,COG1022@2|Bacteria,COG3320@2|Bacteria,1MU4D@1224|Proteobacteria,42NHQ@68525|delta/epsilon subdivisions,2WJZ5@28221|Deltaproteobacteria,2YU6Q@29|Myxococcales	28221|Deltaproteobacteria	IQ	Male sterility protein	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,NAD_binding_4,PP-binding,Sterile
TLS2_k127_326210_7	443143.GM18_0649	1.298e-43	164.0	COG0614@1|root,COG0614@2|Bacteria,1N7EM@1224|Proteobacteria	1224|Proteobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
TLS2_k127_326210_12	1121272.KB903249_gene2071	2.219e-05	50.0	COG0236@1|root,COG0236@2|Bacteria,2GQFI@201174|Actinobacteria,4DF6U@85008|Micromonosporales	201174|Actinobacteria	IQ	Phosphopantetheine attachment site	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS2_k127_326210_11	1356854.N007_12260	1.84e-07	56.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HB73@91061|Bacilli,2788T@186823|Alicyclobacillaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K13767	ko00071,ko00362,ko01100,ko01120,ko01212,map00071,map00362,map01100,map01120,map01212	M00087	R03026,R04170,R04738,R04740,R04744,R04746	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_3334353_24	204669.Acid345_1564	7.268e-38	146.0	COG1573@1|root,COG1573@2|Bacteria,3Y4AT@57723|Acidobacteria,2JJ4U@204432|Acidobacteriia	204432|Acidobacteriia	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_3334353_8	204669.Acid345_1583	3.43e-127	430.0	COG1807@1|root,COG1807@2|Bacteria,3Y2UV@57723|Acidobacteria,2JIS6@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_3334353_27	240015.ACP_3371	8.624e-29	121.0	2E8MJ@1|root,32S5J@2|Bacteria,3Y53W@57723|Acidobacteria,2JNZ2@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF3467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3467
TLS2_k127_3334353_29	204669.Acid345_1582	7.033e-20	95.0	2EEIP@1|root,338CM@2|Bacteria,3Y5Q1@57723|Acidobacteria,2JK0Z@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3334353_20	204669.Acid345_1581	7.908e-60	213.0	COG0316@1|root,COG0316@2|Bacteria,3Y4ZB@57723|Acidobacteria,2JJEX@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the HesB IscA family	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_biosyn
TLS2_k127_3334353_22	1382359.JIAL01000001_gene1453	1.089e-39	159.0	COG2165@1|root,COG2165@2|Bacteria,3Y9CD@57723|Acidobacteria,2JP0S@204432|Acidobacteriia	204432|Acidobacteriia	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3334353_26	204669.Acid345_1579	1.74e-30	128.0	2C8FF@1|root,333TN@2|Bacteria,3Y5GA@57723|Acidobacteria,2JJYB@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3334353_30	1267534.KB906755_gene4779	2.4e-19	96.0	2CEAG@1|root,31NYW@2|Bacteria,3Y52E@57723|Acidobacteria,2JJI1@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
TLS2_k127_3334353_23	204669.Acid345_1577	1.797e-39	157.0	COG4972@1|root,COG4972@2|Bacteria,3Y4X3@57723|Acidobacteria,2JJG9@204432|Acidobacteriia	204432|Acidobacteriia	NU	Pilus assembly protein	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
TLS2_k127_3334353_18	204669.Acid345_1577	2.126e-63	228.0	COG4972@1|root,COG4972@2|Bacteria,3Y4X3@57723|Acidobacteria,2JJG9@204432|Acidobacteriia	204432|Acidobacteriia	NU	Pilus assembly protein	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
TLS2_k127_3334353_1	1382359.JIAL01000001_gene1458	1.869e-265	838.0	COG2804@1|root,COG2804@2|Bacteria,3Y3GB@57723|Acidobacteria,2JHVF@204432|Acidobacteriia	204432|Acidobacteriia	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
TLS2_k127_3334353_6	204669.Acid345_1575	1.057e-136	448.0	COG1459@1|root,COG1459@2|Bacteria,3Y2X8@57723|Acidobacteria,2JHIX@204432|Acidobacteriia	204432|Acidobacteriia	NU	PFAM Type II secretion system F domain	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
TLS2_k127_3334353_19	204669.Acid345_1574	1.77e-61	223.0	COG2834@1|root,COG2834@2|Bacteria,3Y4XE@57723|Acidobacteria,2JJK4@204432|Acidobacteriia	204432|Acidobacteriia	M	outer membrane lipoprotein carrier protein LolA	-	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
TLS2_k127_3334353_13	204669.Acid345_1573	1.863e-89	304.0	COG0457@1|root,COG0457@2|Bacteria	204669.Acid345_1573|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3334353_14	204669.Acid345_1572	2.236e-88	306.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	pilI	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
TLS2_k127_3334353_10	204669.Acid345_1571	2.298e-116	383.0	COG1131@1|root,COG1131@2|Bacteria,3Y7J3@57723|Acidobacteria,2JMS8@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3334353_21	204669.Acid345_1569	6.877e-43	164.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria,2JP4Y@204432|Acidobacteriia	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
TLS2_k127_3334353_3	204669.Acid345_1568	2.123e-192	609.0	COG0612@1|root,COG0612@2|Bacteria,3Y3M9@57723|Acidobacteria,2JHY4@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_3334353_4	204669.Acid345_1567	1.92e-144	467.0	COG0820@1|root,COG0820@2|Bacteria,3Y3HQ@57723|Acidobacteria,2JIT9@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
TLS2_k127_3334353_7	204669.Acid345_1566	5.139e-132	449.0	COG0457@1|root,COG0457@2|Bacteria,3Y6J0@57723|Acidobacteria,2JKHK@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
TLS2_k127_3334353_25	204669.Acid345_2315	6.853e-37	145.0	COG0454@1|root,COG0456@2|Bacteria,3Y5GV@57723|Acidobacteria,2JJZU@204432|Acidobacteriia	204432|Acidobacteriia	K	FR47-like protein	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TLS2_k127_3334353_2	204669.Acid345_2039	5.95e-253	796.0	COG0145@1|root,COG0145@2|Bacteria,3Y6D5@57723|Acidobacteria,2JKXC@204432|Acidobacteriia	204432|Acidobacteriia	EQ	Hydantoinase/oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
TLS2_k127_3334353_33	1121106.JQKB01000057_gene612	3.062e-06	52.0	COG3237@1|root,COG3237@2|Bacteria,1NGW6@1224|Proteobacteria,2UJAV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the UPF0337 (CsbD) family	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
TLS2_k127_3334353_15	204669.Acid345_2043	4.881e-78	274.0	COG0077@1|root,COG0077@2|Bacteria,3Y49H@57723|Acidobacteria,2JJ3X@204432|Acidobacteriia	204432|Acidobacteriia	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
TLS2_k127_3334353_0	204669.Acid345_2051	0.0	1272.0	COG0466@1|root,COG0466@2|Bacteria,3Y2QB@57723|Acidobacteria,2JHMJ@204432|Acidobacteriia	204432|Acidobacteriia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS2_k127_3334353_17	290397.Adeh_1227	1.494e-64	237.0	COG0739@1|root,COG3061@1|root,COG0739@2|Bacteria,COG3061@2|Bacteria,1MVTF@1224|Proteobacteria,42MNF@68525|delta/epsilon subdivisions,2WIYR@28221|Deltaproteobacteria,2YV41@29|Myxococcales	28221|Deltaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_3334353_11	401053.AciPR4_3406	4.714e-102	351.0	COG1231@1|root,COG1231@2|Bacteria,3Y895@57723|Acidobacteria,2JNAN@204432|Acidobacteriia	2|Bacteria	E	Flavin containing amine oxidoreductase	-	-	1.4.3.25,1.4.3.4	ko:K00274,ko:K21639	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS2_k127_3334353_16	1382359.JIAL01000001_gene2419	1.01e-77	270.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,3Y519@57723|Acidobacteria,2JMDU@204432|Acidobacteriia	204432|Acidobacteriia	H	MoaE protein	-	-	2.8.1.12	ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
TLS2_k127_3334353_12	204669.Acid345_2058	7.726e-94	321.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria,2JIRN@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
TLS2_k127_3334353_28	204669.Acid345_2059	1.509e-24	107.0	COG1923@1|root,COG1923@2|Bacteria,3Y5PK@57723|Acidobacteria,2JJYT@204432|Acidobacteriia	204432|Acidobacteriia	S	Hfq protein	-	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
TLS2_k127_3334353_9	204669.Acid345_2060	1.765e-123	400.0	COG0483@1|root,COG0483@2|Bacteria,3Y3GD@57723|Acidobacteria,2JHRB@204432|Acidobacteriia	204432|Acidobacteriia	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS2_k127_3334353_31	234267.Acid_6018	4.414e-15	86.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	ko:K02487,ko:K03832,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02000,ko02022,ko02035	2.C.1.1	-	-	CarbopepD_reg_2,FabA,KAsynt_C_assoc,Ketoacyl-synt_C,TonB_2,TonB_C,ketoacyl-synt
TLS2_k127_3334353_5	13690.CP98_02413	7.765e-143	465.0	COG0520@1|root,COG0520@2|Bacteria,1MXH1@1224|Proteobacteria,2TQUT@28211|Alphaproteobacteria,2K25H@204457|Sphingomonadales	204457|Sphingomonadales	E	Selenocysteine lyase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_3364255_0	234267.Acid_6621	9.507e-66	245.0	COG1596@1|root,COG1596@2|Bacteria	2|Bacteria	M	polysaccharide export	-	-	-	ko:K01991,ko:K16552	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18,1.B.18.1	-	-	NTP_transf_5,Poly_export,SLBB
TLS2_k127_3364255_1	192952.MM_3319	0.0002074	54.0	COG0477@1|root,arCOG00132@2157|Archaea,2XYHV@28890|Euryarchaeota,2NAK2@224756|Methanomicrobia	224756|Methanomicrobia	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_3515553_5	204669.Acid345_4470	6.849e-86	287.0	COG0138@1|root,COG0138@2|Bacteria,3Y2QI@57723|Acidobacteria,2JHSU@204432|Acidobacteriia	204432|Acidobacteriia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
TLS2_k127_3515553_0	204669.Acid345_4603	1.085e-225	721.0	COG0457@1|root,COG0457@2|Bacteria,3Y35N@57723|Acidobacteria,2JHIM@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
TLS2_k127_3515553_1	204669.Acid345_4602	1.525e-158	507.0	COG0232@1|root,COG0232@2|Bacteria,3Y2S2@57723|Acidobacteria,2JIHE@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the dGTPase family. Type 2 subfamily	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
TLS2_k127_3515553_11	204669.Acid345_4524	4.438e-54	212.0	COG0265@1|root,COG0265@2|Bacteria,3Y4AJ@57723|Acidobacteria,2JJ4W@204432|Acidobacteriia	204432|Acidobacteriia	O	PDZ DHR GLGF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2
TLS2_k127_3515553_8	204669.Acid345_4525	5.804e-63	234.0	COG3595@1|root,COG3595@2|Bacteria,3Y8P5@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3515553_6	204669.Acid345_4526	8.209e-83	285.0	COG1413@1|root,COG5662@1|root,COG1413@2|Bacteria,COG5662@2|Bacteria,3Y2TB@57723|Acidobacteria,2JHKS@204432|Acidobacteriia	204432|Acidobacteriia	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,zf-HC2
TLS2_k127_3515553_4	204669.Acid345_4527	1.199e-95	318.0	COG1595@1|root,COG1595@2|Bacteria,3Y4CH@57723|Acidobacteria,2JJ6R@204432|Acidobacteriia	204432|Acidobacteriia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_3515553_10	1382359.JIAL01000001_gene1373	1.882e-57	207.0	COG0359@1|root,COG0359@2|Bacteria,3Y4MD@57723|Acidobacteria,2JJAN@204432|Acidobacteriia	204432|Acidobacteriia	J	binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
TLS2_k127_3515553_12	1267533.KB906734_gene4260	1.388e-42	159.0	COG0238@1|root,COG0238@2|Bacteria,3Y53K@57723|Acidobacteria,2JN1Z@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal protein S18	-	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
TLS2_k127_3515553_13	204669.Acid345_4537	2.175e-41	156.0	COG0360@1|root,COG0360@2|Bacteria,3Y50N@57723|Acidobacteria,2JJHP@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
TLS2_k127_3515553_9	1382359.JIAL01000001_gene1376	7.439e-61	224.0	COG0193@1|root,COG0193@2|Bacteria,3Y48V@57723|Acidobacteria,2JJ31@204432|Acidobacteriia	204432|Acidobacteriia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
TLS2_k127_3515553_7	1382359.JIAL01000001_gene1377	8.755e-81	275.0	COG1825@1|root,COG1825@2|Bacteria,3Y41C@57723|Acidobacteria,2JHW5@204432|Acidobacteriia	204432|Acidobacteriia	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
TLS2_k127_3515553_2	204669.Acid345_4540	5.534e-155	501.0	COG0462@1|root,COG0462@2|Bacteria,3Y3KV@57723|Acidobacteria,2JHTF@204432|Acidobacteriia	204432|Acidobacteriia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
TLS2_k127_3515553_3	204669.Acid345_4541	7.312e-98	329.0	COG1947@1|root,COG1947@2|Bacteria,3Y2QX@57723|Acidobacteria,2JIDT@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_3533973_1	686578.AFFX01000007_gene3452	3.213e-05	56.0	COG5421@1|root,COG5421@2|Bacteria,1QUUP@1224|Proteobacteria,1T21N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	to Shigella flexneri,and Shigella flexneri 2A IS10 orf S0034 or Cp0027 SWALL Q9AFX7 (EMBL AF348706) (407 aa) fasta scores E()	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TLS2_k127_3533973_0	189425.PGRAT_30775	6.488e-25	109.0	COG1680@1|root,COG1680@2|Bacteria,1V4BS@1239|Firmicutes,4HJRT@91061|Bacilli,26R26@186822|Paenibacillaceae	91061|Bacilli	V	Beta-lactamase class C and other penicillin binding proteins	pbpX	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,SLH
TLS2_k127_3534001_5	682795.AciX8_1765	2.09e-11	65.0	COG3209@1|root,COG3209@2|Bacteria,3Y5Q3@57723|Acidobacteria,2JJZC@204432|Acidobacteriia	204432|Acidobacteriia	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
TLS2_k127_3534001_0	234267.Acid_6973	1.527e-285	891.0	COG1966@1|root,COG1966@2|Bacteria,3Y436@57723|Acidobacteria	57723|Acidobacteria	T	5TM C-terminal transporter carbon starvation CstA	-	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
TLS2_k127_3534001_1	1191523.MROS_0402	2.626e-220	696.0	COG2978@1|root,COG2978@2|Bacteria	2|Bacteria	H	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity	ydaH	-	-	ko:K12942	-	-	-	-	ko00000	-	-	-	ABG_transport
TLS2_k127_3534001_2	247490.KSU1_C0674	1.322e-57	209.0	COG0730@1|root,COG0730@2|Bacteria,2IY5M@203682|Planctomycetes	203682|Planctomycetes	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_3534001_4	880073.Calab_1319	4.212e-13	68.0	COG1249@1|root,COG1249@2|Bacteria,2NQMY@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3)	lpdA	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006103,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006520,GO:0006544,GO:0006546,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009071,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015036,GO:0016054,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017144,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019464,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0036211,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045250,GO:0045252,GO:0045254,GO:0046390,GO:0046395,GO:0046483,GO:0046496,GO:0046872,GO:0046914,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0065007,GO:0065008,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0097159,GO:0106077,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAPECO1_1312.APECO1_1869,iEcolC_1368.EcolC_3543,iPC815.YPO3417,iSFV_1184.SFV_0107,iUMN146_1321.UM146_23385	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
TLS2_k127_3535344_1	1382359.JIAL01000001_gene2811	9.642e-84	289.0	COG1496@1|root,COG1496@2|Bacteria,3Y3J1@57723|Acidobacteria,2JHKU@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
TLS2_k127_3535344_4	639030.JHVA01000001_gene291	8.881e-07	55.0	COG2199@1|root,COG3706@2|Bacteria,3Y4YP@57723|Acidobacteria,2JJE2@204432|Acidobacteriia	204432|Acidobacteriia	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3535344_2	643562.Daes_2568	7.914e-20	98.0	COG0730@1|root,COG0730@2|Bacteria,1RBHH@1224|Proteobacteria,42R9E@68525|delta/epsilon subdivisions,2WNRJ@28221|Deltaproteobacteria,2MAXH@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_3535344_0	251221.35212389	8.931e-85	285.0	COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria	1117|Cyanobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
TLS2_k127_3575490_1	1382359.JIAL01000001_gene938	2.962e-74	276.0	COG0438@1|root,COG0438@2|Bacteria,3Y6T4@57723|Acidobacteria,2JMK3@204432|Acidobacteriia	204432|Acidobacteriia	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glycos_transf_1
TLS2_k127_3575490_0	1267533.KB906735_gene4473	9.924e-133	449.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3580585_1	1382359.JIAL01000001_gene2272	3.128e-97	327.0	COG1028@1|root,COG1028@2|Bacteria,3Y3YM@57723|Acidobacteria,2JI6U@204432|Acidobacteriia	204432|Acidobacteriia	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_3580585_4	204669.Acid345_0267	1.464e-50	182.0	COG1396@1|root,COG1396@2|Bacteria,3Y52W@57723|Acidobacteria,2JJE1@204432|Acidobacteriia	204432|Acidobacteriia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS2_k127_3580585_2	204669.Acid345_0268	2.859e-84	284.0	COG2197@1|root,COG2197@2|Bacteria,3Y2WY@57723|Acidobacteria,2JIR0@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_3580585_3	204669.Acid345_0269	1.958e-68	239.0	2ENGH@1|root,33G40@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3580585_5	1279009.ADICEAN_03620	2.192e-21	102.0	COG3485@1|root,COG3485@2|Bacteria,4NEZ1@976|Bacteroidetes,47QHP@768503|Cytophagia	976|Bacteroidetes	Q	Dioxygenase	-	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
TLS2_k127_3580585_0	204669.Acid345_4470	6.858e-153	492.0	COG0138@1|root,COG0138@2|Bacteria,3Y2QI@57723|Acidobacteria,2JHSU@204432|Acidobacteriia	204432|Acidobacteriia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
TLS2_k127_3582219_0	1382359.JIAL01000001_gene135	1.543e-242	760.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,3Y3NX@57723|Acidobacteria,2JKIA@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
TLS2_k127_3584313_3	1121123.AUAO01000001_gene1445	5.529e-33	132.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,2KFH3@204458|Caulobacterales	204458|Caulobacterales	K	phosphate regulon transcriptional regulatory protein PhoB	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_3584313_4	1123386.AUIW01000015_gene554	2.211e-13	79.0	COG0484@1|root,COG0484@2|Bacteria,1WI37@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_3584313_1	292459.STH2398	9.217e-70	254.0	COG0745@1|root,COG2202@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1VRP7@1239|Firmicutes,24YHW@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS_9,Response_reg
TLS2_k127_3584313_2	292459.STH2399	3.217e-38	147.0	COG0745@1|root,COG0745@2|Bacteria,1VHJ1@1239|Firmicutes,24QWF@186801|Clostridia	186801|Clostridia	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_3584313_0	292459.STH2398	9.62e-82	302.0	COG0745@1|root,COG2202@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1VRP7@1239|Firmicutes,24YHW@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS_9,Response_reg
TLS2_k127_3584313_6	504472.Slin_5224	0.0009216	50.0	2A3W2@1|root,30SE9@2|Bacteria	2|Bacteria	L	PD-(D/E)XK endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_5
TLS2_k127_3584313_5	1115632.JAFW01000001_gene4196	9.465e-07	58.0	COG2931@1|root,COG2931@2|Bacteria,2I945@201174|Actinobacteria	201174|Actinobacteria	Q	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_4_9,F5_F8_type_C,Laminin_G_3
TLS2_k127_3612050_2	379066.GAU_3641	1.585e-38	151.0	2CHCP@1|root,32S5R@2|Bacteria,1ZV1V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS2_k127_3612050_0	1191523.MROS_0754	7.511e-245	780.0	COG1361@1|root,COG1472@1|root,COG1361@2|Bacteria,COG1472@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 3 family	bglX2	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Beta_helix,CUB,Calx-beta,DUF11,Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14,SdrD_B
TLS2_k127_3612050_1	204669.Acid345_0532	2.53e-129	430.0	COG1629@1|root,COG4771@2|Bacteria,3Y2MF@57723|Acidobacteria,2JHJU@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_3648663_1	927677.ALVU02000001_gene4671	6.769e-12	79.0	COG1462@1|root,COG1462@2|Bacteria,1G43J@1117|Cyanobacteria,1H5ZU@1142|Synechocystis	1117|Cyanobacteria	M	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
TLS2_k127_3648663_0	1122137.AQXF01000003_gene2417	2e-118	397.0	COG2234@1|root,COG2234@2|Bacteria,1NVWC@1224|Proteobacteria	1224|Proteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_3713819_2	204669.Acid345_0626	1.518e-161	519.0	COG4992@1|root,COG4992@2|Bacteria,3Y36P@57723|Acidobacteria,2JISH@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class-III	-	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_3713819_4	1267534.KB906755_gene4162	6.059e-65	232.0	COG2267@1|root,COG2267@2|Bacteria,3Y4Q6@57723|Acidobacteria,2JJ7I@204432|Acidobacteriia	204432|Acidobacteriia	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_3713819_10	521096.Tpau_1917	9.194e-07	55.0	2E4Q9@1|root,32ZIV@2|Bacteria,2II59@201174|Actinobacteria	201174|Actinobacteria	S	Putative transmembrane protein (PGPGW)	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
TLS2_k127_3713819_0	204669.Acid345_0630	1.341e-172	556.0	COG1721@1|root,COG1721@2|Bacteria,3Y5V9@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_3713819_9	338963.Pcar_2627	2.464e-07	62.0	2EHUK@1|root,33BK8@2|Bacteria,1Q1PA@1224|Proteobacteria,437D9@68525|delta/epsilon subdivisions,2X2JB@28221|Deltaproteobacteria,43VPA@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3713819_6	204669.Acid345_0631	1.498e-37	151.0	COG2905@1|root,COG2905@2|Bacteria,3Y5NG@57723|Acidobacteria,2JN0N@204432|Acidobacteriia	204432|Acidobacteriia	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_3713819_8	760568.Desku_2012	3.767e-09	59.0	COG0695@1|root,COG0695@2|Bacteria,1VI6J@1239|Firmicutes,24QNT@186801|Clostridia,26396@186807|Peptococcaceae	186801|Clostridia	O	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
TLS2_k127_3713819_1	234267.Acid_1055	7.065e-171	550.0	COG0277@1|root,COG0277@2|Bacteria,3Y68N@57723|Acidobacteria	57723|Acidobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_3713819_5	479434.Sthe_0986	3.386e-54	217.0	COG0277@1|root,COG0277@2|Bacteria,2G6FW@200795|Chloroflexi,27XX4@189775|Thermomicrobia	189775|Thermomicrobia	C	FAD linked oxidases, C-terminal domain	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_3713819_3	1267535.KB906767_gene470	3.607e-99	332.0	COG0247@1|root,COG0247@2|Bacteria,3Y6NT@57723|Acidobacteria	57723|Acidobacteria	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
TLS2_k127_3758495_1	204669.Acid345_0192	6.416e-100	336.0	COG0604@1|root,COG0604@2|Bacteria,3Y4X4@57723|Acidobacteria,2JJDX@204432|Acidobacteriia	204432|Acidobacteriia	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_3758495_0	204669.Acid345_0035	1.887e-105	350.0	COG0313@1|root,COG0313@2|Bacteria,3Y32N@57723|Acidobacteria,2JIGR@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
TLS2_k127_3758495_2	1267534.KB906760_gene1554	4.44e-34	134.0	2DD3Z@1|root,2ZGDH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3758495_3	204669.Acid345_0034	2.184e-22	100.0	COG2331@1|root,COG2331@2|Bacteria,3Y5KN@57723|Acidobacteria,2JJW0@204432|Acidobacteriia	204432|Acidobacteriia	S	Regulatory protein, FmdB	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TLS2_k127_3758495_5	861299.J421_1046	3.635e-06	50.0	2EIK5@1|root,33CBF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_376132_0	204669.Acid345_0784	6.002e-253	814.0	COG1629@1|root,COG4771@2|Bacteria,3Y33S@57723|Acidobacteria,2JK9M@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_376132_1	204669.Acid345_4432	7.223e-196	629.0	COG2203@1|root,COG2206@1|root,COG3437@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3437@2|Bacteria,3Y61X@57723|Acidobacteria	57723|Acidobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD_5
TLS2_k127_379336_3	204669.Acid345_3765	1.654e-84	291.0	COG2197@1|root,COG2197@2|Bacteria,3Y40U@57723|Acidobacteria,2JHRE@204432|Acidobacteriia	204432|Acidobacteriia	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_379336_4	1267534.KB906756_gene384	4.727e-21	96.0	2E21T@1|root,32X9H@2|Bacteria,3Y5D6@57723|Acidobacteria,2JJQA@204432|Acidobacteriia	204432|Acidobacteriia	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
TLS2_k127_379336_2	204669.Acid345_3766	1.849e-161	534.0	COG0312@1|root,COG0312@2|Bacteria,3Y7SM@57723|Acidobacteria	57723|Acidobacteria	L	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
TLS2_k127_379336_1	204669.Acid345_3767	9.309e-251	782.0	COG0312@1|root,COG0312@2|Bacteria,3Y6TF@57723|Acidobacteria	57723|Acidobacteria	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS2_k127_379336_5	204669.Acid345_3019	1.017e-19	100.0	COG0745@1|root,COG0745@2|Bacteria	204669.Acid345_3019|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_379336_0	204669.Acid345_3770	0.0	1865.0	COG1201@1|root,COG1201@2|Bacteria,3Y348@57723|Acidobacteria,2JIVQ@204432|Acidobacteriia	204432|Acidobacteriia	L	dead deah	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
TLS2_k127_3797811_11	401053.AciPR4_3532	1.293e-07	63.0	COG2304@1|root,COG2304@2|Bacteria,3Y3DR@57723|Acidobacteria,2JHJT@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM VWFA-related Acidobacterial domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3797811_8	926566.Terro_1287	8.364e-40	167.0	2DBAV@1|root,2Z84I@2|Bacteria,3Y2PF@57723|Acidobacteria,2JIIF@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3797811_6	1198114.AciX9_1258	1.486e-52	208.0	2DBAV@1|root,2Z84I@2|Bacteria,3Y2PF@57723|Acidobacteria,2JIIF@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3797811_3	1382359.JIAL01000001_gene24	5.129e-101	340.0	COG0009@1|root,COG0009@2|Bacteria,3Y3VW@57723|Acidobacteria,2JHTT@204432|Acidobacteriia	204432|Acidobacteriia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
TLS2_k127_3797811_4	234267.Acid_3198	6.52e-80	272.0	COG1435@1|root,COG1435@2|Bacteria,3Y4XG@57723|Acidobacteria	57723|Acidobacteria	F	PFAM Thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
TLS2_k127_3797811_1	644966.Tmar_0252	1.525e-135	443.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,25CRT@186801|Clostridia	186801|Clostridia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
TLS2_k127_3797811_10	867845.KI911784_gene3184	5.041e-21	106.0	COG0425@1|root,COG0425@2|Bacteria,2G7DF@200795|Chloroflexi,377DX@32061|Chloroflexia	32061|Chloroflexia	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
TLS2_k127_3797811_5	926550.CLDAP_30490	3.76e-63	222.0	COG2210@1|root,COG2210@2|Bacteria,2G77F@200795|Chloroflexi	200795|Chloroflexi	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
TLS2_k127_3797811_9	671143.DAMO_1259	6.948e-38	150.0	COG1309@1|root,COG1309@2|Bacteria,2NQ8G@2323|unclassified Bacteria	2|Bacteria	K	Bacterial regulatory proteins, tetR family	MA20_16815	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_3797811_2	269799.Gmet_1651	1.616e-107	362.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,42NJG@68525|delta/epsilon subdivisions,2WJ8R@28221|Deltaproteobacteria,43US6@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TLS2_k127_3797811_0	243231.GSU1611	0.0	1294.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43T46@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K07788,ko:K07789,ko:K18138	ko01501,ko01503,ko02020,map01501,map01503,map02020	M00647,M00648,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
TLS2_k127_3804557_15	536232.CLM_3847	1.296e-12	74.0	COG1716@1|root,COG1716@2|Bacteria,1VF0E@1239|Firmicutes,24P12@186801|Clostridia,36KT8@31979|Clostridiaceae	186801|Clostridia	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
TLS2_k127_3804557_6	204669.Acid345_4330	1.775e-87	306.0	COG0631@1|root,COG0631@2|Bacteria,3Y4SV@57723|Acidobacteria,2JJFU@204432|Acidobacteriia	204432|Acidobacteriia	T	Protein phosphatase 2C	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
TLS2_k127_3804557_2	398767.Glov_1587	3.401e-227	732.0	COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase
TLS2_k127_3804557_7	204669.Acid345_4331	8.015e-46	170.0	COG0355@1|root,COG0355@2|Bacteria,3Y515@57723|Acidobacteria,2JJJV@204432|Acidobacteriia	204432|Acidobacteriia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
TLS2_k127_3804557_0	204669.Acid345_4332	2.618e-269	833.0	COG0055@1|root,COG0055@2|Bacteria,3Y2PU@57723|Acidobacteria,2JIDM@204432|Acidobacteriia	204432|Acidobacteriia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS2_k127_3804557_5	204669.Acid345_4333	2.097e-138	449.0	COG0224@1|root,COG0224@2|Bacteria,3Y3MN@57723|Acidobacteria,2JHVH@204432|Acidobacteriia	204432|Acidobacteriia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
TLS2_k127_3804557_1	204669.Acid345_4334	2.709e-267	830.0	COG0056@1|root,COG0056@2|Bacteria,3Y2R6@57723|Acidobacteria,2JIEV@204432|Acidobacteriia	204432|Acidobacteriia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
TLS2_k127_3804557_9	204669.Acid345_4335	1.604e-41	162.0	COG0712@1|root,COG0712@2|Bacteria,3Y4Z4@57723|Acidobacteria,2JJM8@204432|Acidobacteriia	204432|Acidobacteriia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
TLS2_k127_3804557_11	278963.ATWD01000001_gene4262	1.59e-30	130.0	COG0711@1|root,COG0711@2|Bacteria,3Y4UJ@57723|Acidobacteria,2JJIS@204432|Acidobacteriia	204432|Acidobacteriia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
TLS2_k127_3804557_10	204669.Acid345_4337	7.918e-37	145.0	COG0711@1|root,COG0711@2|Bacteria,3Y4WK@57723|Acidobacteria,2JJH3@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the ATPase B chain family	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
TLS2_k127_3804557_3	204669.Acid345_4340	1.783e-165	533.0	COG2262@1|root,COG2262@2|Bacteria,3Y2FK@57723|Acidobacteria,2JI0F@204432|Acidobacteriia	204432|Acidobacteriia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TLS2_k127_3804557_12	204669.Acid345_4341	6.818e-27	125.0	COG1923@1|root,COG1923@2|Bacteria,3Y59T@57723|Acidobacteria,2JJSQ@204432|Acidobacteriia	204432|Acidobacteriia	S	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
TLS2_k127_3804557_8	204669.Acid345_4342	1.165e-44	172.0	COG3748@1|root,COG3748@2|Bacteria	2|Bacteria	S	Urate oxidase N-terminal	MA20_17625	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
TLS2_k127_3804557_14	1210884.HG799464_gene10802	1.002e-15	87.0	COG1547@1|root,COG1547@2|Bacteria,2J0XW@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF309)	-	-	-	ko:K09763	-	-	-	-	ko00000	-	-	-	DUF309
TLS2_k127_3804557_4	204669.Acid345_4343	9.784e-141	460.0	COG0399@1|root,COG0399@2|Bacteria,3Y2G1@57723|Acidobacteria,2JI3T@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_3804557_13	204669.Acid345_4347	7.193e-18	83.0	arCOG12677@1|root,2ZCT8@2|Bacteria,3Y95Y@57723|Acidobacteria,2JNVX@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3807192_13	204669.Acid345_2469	1.886e-36	141.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,3Y2RB@57723|Acidobacteria,2JIRW@204432|Acidobacteriia	204432|Acidobacteriia	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1,ECH_2
TLS2_k127_3807192_11	204669.Acid345_2468	5.643e-44	166.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS2_k127_3807192_5	204669.Acid345_2467	2.418e-111	367.0	COG1752@1|root,COG1752@2|Bacteria,3Y4B2@57723|Acidobacteria,2JJ4V@204432|Acidobacteriia	57723|Acidobacteria	M	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS2_k127_3807192_2	1499967.BAYZ01000028_gene1366	3.226e-157	514.0	COG3653@1|root,COG3653@2|Bacteria,2NNQ0@2323|unclassified Bacteria	2|Bacteria	Q	Amidohydrolase family	dan	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
TLS2_k127_3807192_16	479434.Sthe_0334	8.485e-23	107.0	COG1956@1|root,COG1956@2|Bacteria,2GA0T@200795|Chloroflexi,27YG6@189775|Thermomicrobia	189775|Thermomicrobia	T	GAF domain	-	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF_2
TLS2_k127_3807192_8	644966.Tmar_1967	5.997e-103	342.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,3WCW3@538999|Clostridiales incertae sedis	186801|Clostridia	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS2_k127_3807192_6	234267.Acid_2452	4.163e-111	367.0	COG3958@1|root,COG3958@2|Bacteria,3Y7P5@57723|Acidobacteria	57723|Acidobacteria	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_3807192_0	1382359.JIAL01000001_gene1040	7.07e-301	931.0	COG0504@1|root,COG0504@2|Bacteria,3Y2MH@57723|Acidobacteria,2JID4@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
TLS2_k127_3807192_12	640511.BC1002_1497	1.004e-37	145.0	COG2350@1|root,COG2350@2|Bacteria,1MZ8Y@1224|Proteobacteria,2W38Q@28216|Betaproteobacteria,1K9C8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
TLS2_k127_3807192_10	234267.Acid_0448	7.496e-53	193.0	COG2318@1|root,COG2318@2|Bacteria,3Y85M@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_3807192_7	1122927.KB895414_gene5126	7.566e-106	359.0	COG0604@1|root,COG0604@2|Bacteria,1TQ0M@1239|Firmicutes,4HA8M@91061|Bacilli,26QXS@186822|Paenibacillaceae	91061|Bacilli	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
TLS2_k127_3807192_9	1123073.KB899241_gene2873	5.438e-62	224.0	arCOG07533@1|root,2ZF5I@2|Bacteria,1RB8D@1224|Proteobacteria,1SBRH@1236|Gammaproteobacteria,1X79G@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
TLS2_k127_3807192_4	204669.Acid345_3669	2.363e-111	366.0	COG2877@1|root,COG2877@2|Bacteria,3Y2WF@57723|Acidobacteria,2JI7M@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM DAHP synthetase I	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
TLS2_k127_3807192_1	204669.Acid345_3659	2.804e-179	568.0	COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,3Y40V@57723|Acidobacteria,2JI0P@204432|Acidobacteriia	204432|Acidobacteriia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF
TLS2_k127_3807192_17	234267.Acid_6303	1.402e-21	105.0	COG1426@1|root,COG1426@2|Bacteria,3Y5KP@57723|Acidobacteria	57723|Acidobacteria	S	Helix-turn-helix domain	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
TLS2_k127_3807192_3	1267533.KB906734_gene3683	5.079e-123	406.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_3821508_0	234267.Acid_4385	0.0	1039.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,PA14
TLS2_k127_3821508_4	234267.Acid_4384	2.855e-69	243.0	COG3794@1|root,COG3794@2|Bacteria,3Y4A0@57723|Acidobacteria	57723|Acidobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_3821508_6	518766.Rmar_1786	1.036e-52	199.0	COG1612@1|root,COG1612@2|Bacteria,4PEIM@976|Bacteroidetes,1FJ6F@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	Cytochrome oxidase assembly protein	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
TLS2_k127_3821508_2	204669.Acid345_2218	4.568e-104	362.0	COG0109@1|root,COG0109@2|Bacteria,3Y3VI@57723|Acidobacteria,2JIRB@204432|Acidobacteriia	204432|Acidobacteriia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
TLS2_k127_3821508_1	204669.Acid345_2220	2.431e-130	439.0	COG1131@1|root,COG1131@2|Bacteria,3Y3I9@57723|Acidobacteria,2JIPJ@204432|Acidobacteriia	204432|Acidobacteriia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3821508_3	204669.Acid345_2221	5.989e-84	294.0	COG0842@1|root,COG0842@2|Bacteria,3Y2S4@57723|Acidobacteria,2JISC@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_3821508_7	204669.Acid345_2222	7.592e-36	152.0	COG2322@1|root,COG2322@2|Bacteria,3Y4U9@57723|Acidobacteria,2JJKU@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF420)	-	-	-	ko:K08976	-	-	-	-	ko00000	-	-	-	DUF420
TLS2_k127_3821508_5	234267.Acid_5454	1.559e-60	218.0	COG0511@1|root,COG1413@1|root,COG0511@2|Bacteria,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	pcmV	-	2.3.1.12	ko:K00627,ko:K02160,ko:K07402	ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00307,M00376	R00209,R00742,R02569	RC00004,RC00040,RC00367,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,MDMPI_C,MDMPI_N,XdhC_C,XdhC_CoxI
TLS2_k127_3841339_19	204669.Acid345_1420	1.007e-41	156.0	COG0750@1|root,COG0750@2|Bacteria,3Y2KN@57723|Acidobacteria,2JI1B@204432|Acidobacteriia	204432|Acidobacteriia	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
TLS2_k127_3841339_7	204669.Acid345_1423	3.63e-153	496.0	COG0821@1|root,COG0821@2|Bacteria,3Y2GU@57723|Acidobacteria,2JHND@204432|Acidobacteriia	204432|Acidobacteriia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TLS2_k127_3841339_17	204669.Acid345_1423	1.934e-43	160.0	COG0821@1|root,COG0821@2|Bacteria,3Y2GU@57723|Acidobacteria,2JHND@204432|Acidobacteriia	204432|Acidobacteriia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TLS2_k127_3841339_14	215803.DB30_2099	1.443e-77	270.0	COG1801@1|root,COG1801@2|Bacteria,1N4QE@1224|Proteobacteria,42PDW@68525|delta/epsilon subdivisions,2WK6H@28221|Deltaproteobacteria,2YVUI@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS2_k127_3841339_22	204669.Acid345_1407	4.361e-34	147.0	COG2340@1|root,COG2340@2|Bacteria,3Y4KF@57723|Acidobacteria,2JJCG@204432|Acidobacteriia	204432|Acidobacteriia	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
TLS2_k127_3841339_11	247490.KSU1_C0355	2.309e-131	439.0	COG1322@1|root,COG1322@2|Bacteria,2J2TY@203682|Planctomycetes	203682|Planctomycetes	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
TLS2_k127_3841339_1	204669.Acid345_3840	4.331e-257	831.0	COG1470@1|root,COG1629@1|root,COG1470@2|Bacteria,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K13735,ko:K20276	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001	-	-	-	ASH,CarboxypepD_reg,DUF11,FlgD_ig,HYR,Laminin_G_3,Plug,TonB_dep_Rec
TLS2_k127_3841339_9	204669.Acid345_1395	1.886e-137	442.0	COG1173@1|root,COG1173@2|Bacteria,3Y45P@57723|Acidobacteria,2JIKH@204432|Acidobacteriia	204432|Acidobacteriia	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_3841339_8	204669.Acid345_3533	1.283e-145	466.0	COG0601@1|root,COG0601@2|Bacteria,3Y437@57723|Acidobacteria,2JHY6@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_3841339_5	204669.Acid345_3532	1.295e-167	542.0	COG1253@1|root,COG1253@2|Bacteria,3Y2KE@57723|Acidobacteria,2JHJ4@204432|Acidobacteriia	204432|Acidobacteriia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_3841339_15	696747.NIES39_Q00740	2.981e-76	258.0	COG2345@1|root,COG2345@2|Bacteria,1G44B@1117|Cyanobacteria,1HAJI@1150|Oscillatoriales	1117|Cyanobacteria	K	Transcriptional regulator	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_3841339_13	1198114.AciX9_0549	2.391e-83	301.0	COG2202@1|root,COG2461@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2461@2|Bacteria,COG4191@2|Bacteria,3Y6VM@57723|Acidobacteria,2JKH6@204432|Acidobacteriia	204432|Acidobacteriia	T	PAS PAC sensor signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
TLS2_k127_3841339_6	204669.Acid345_3531	2.359e-160	515.0	COG0845@1|root,COG0845@2|Bacteria,3Y2F6@57723|Acidobacteria,2JI56@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
TLS2_k127_3841339_16	204669.Acid345_3530	2.488e-59	218.0	COG3595@1|root,COG3595@2|Bacteria,3Y4HG@57723|Acidobacteria,2JJ7G@204432|Acidobacteriia	204432|Acidobacteriia	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_3841339_12	204669.Acid345_3529	5.696e-102	338.0	COG1912@1|root,COG1912@2|Bacteria,3Y50E@57723|Acidobacteria,2JMWN@204432|Acidobacteriia	204432|Acidobacteriia	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
TLS2_k127_3841339_23	204669.Acid345_3528	2.623e-29	118.0	2EKYQ@1|root,33EN7@2|Bacteria,3Y5T5@57723|Acidobacteria,2JK2W@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3841339_24	1198452.Jab_2c23300	4.947e-21	100.0	2E902@1|root,3339H@2|Bacteria,1N9U6@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3841339_18	1346791.M529_17320	3.131e-43	161.0	COG0346@1|root,COG0346@2|Bacteria,1RF1Z@1224|Proteobacteria,2U7I9@28211|Alphaproteobacteria,2K6PI@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_3841339_20	926560.KE387027_gene420	1.27e-40	164.0	COG1733@1|root,COG1733@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS2_k127_3841339_21	204669.Acid345_3527	6.406e-40	151.0	COG0457@1|root,COG0457@2|Bacteria	204669.Acid345_3527|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3841339_10	330214.NIDE0779	1.074e-132	437.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_3841339_4	204669.Acid345_1389	4.366e-188	604.0	COG3852@1|root,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_8
TLS2_k127_3841339_3	204669.Acid345_1390	9.958e-190	599.0	COG1459@1|root,COG1459@2|Bacteria,3Y2X8@57723|Acidobacteria,2JHIX@204432|Acidobacteriia	2|Bacteria	NU	PFAM Type II secretion system F domain	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
TLS2_k127_3841339_2	204669.Acid345_1391	9.1e-195	612.0	COG2805@1|root,COG2805@2|Bacteria,3Y316@57723|Acidobacteria,2JIT4@204432|Acidobacteriia	204432|Acidobacteriia	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TLS2_k127_3841339_0	204669.Acid345_1392	5.763e-303	942.0	COG2804@1|root,COG2804@2|Bacteria,3Y3GB@57723|Acidobacteria,2JHVF@204432|Acidobacteriia	2|Bacteria	NU	PFAM Type II secretion system protein E	pilB	-	-	ko:K02454,ko:K02504,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
TLS2_k127_3854835_6	234267.Acid_4660	2.859e-42	161.0	COG0250@1|root,COG0250@2|Bacteria,3Y83Z@57723|Acidobacteria	57723|Acidobacteria	K	Transcription termination factor nusG	-	-	-	-	-	-	-	-	-	-	-	-	NusG
TLS2_k127_3854835_2	335543.Sfum_0975	9.714e-103	347.0	COG2148@1|root,COG2199@1|root,COG2148@2|Bacteria,COG3706@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria,2MRYR@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Undecaprenyl-phosphate galactose phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS2_k127_3854835_1	1267534.KB906755_gene4124	5.07e-160	511.0	COG0673@1|root,COG0673@2|Bacteria,3Y486@57723|Acidobacteria,2JHJI@204432|Acidobacteriia	204432|Acidobacteriia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_3854835_5	1116472.MGMO_57c00340	8.418e-73	261.0	COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,1RRUD@1236|Gammaproteobacteria,1XFCW@135618|Methylococcales	135618|Methylococcales	S	Glycosyl transferase	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3
TLS2_k127_3854835_4	1267534.KB906755_gene4123	6.634e-73	249.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	wbpD	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
TLS2_k127_3854835_0	1267534.KB906755_gene4122	3.106e-162	520.0	COG0399@1|root,COG0399@2|Bacteria,3Y3PT@57723|Acidobacteria,2JHVI@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.98	ko:K13017	ko00520,map00520	-	R10141	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_3854835_3	1116472.MGMO_57c00300	6.391e-74	261.0	COG1035@1|root,COG1035@2|Bacteria,1R45V@1224|Proteobacteria,1RSF5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1035 Coenzyme F420-reducing hydrogenase, beta subunit	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	FrhB_FdhB_C,FrhB_FdhB_N
TLS2_k127_3878901_1	204669.Acid345_4656	1.218e-46	186.0	COG0272@1|root,COG0272@2|Bacteria,3Y2UR@57723|Acidobacteria,2JHN1@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
TLS2_k127_3878901_4	682795.AciX8_1781	6.066e-35	150.0	COG1597@1|root,COG1597@2|Bacteria,3Y5Q9@57723|Acidobacteria,2JJN4@204432|Acidobacteriia	204432|Acidobacteriia	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS2_k127_3878901_0	204669.Acid345_4651	6.334e-88	304.0	COG1988@1|root,COG1988@2|Bacteria,3Y305@57723|Acidobacteria,2JHQ5@204432|Acidobacteriia	204432|Acidobacteriia	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
TLS2_k127_3878901_5	240015.ACP_2229	2.602e-25	117.0	2CBKC@1|root,32RTJ@2|Bacteria,3Y4V8@57723|Acidobacteria,2JJES@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3878901_3	204669.Acid345_4653	3.186e-45	171.0	COG1238@1|root,COG1238@2|Bacteria,3Y52F@57723|Acidobacteria,2JJK2@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_3878901_2	639030.JHVA01000001_gene1811	1.085e-45	170.0	COG0521@1|root,COG0521@2|Bacteria,3Y504@57723|Acidobacteria,2JJI8@204432|Acidobacteriia	204432|Acidobacteriia	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
TLS2_k127_3886999_2	204669.Acid345_3068	8.392e-206	647.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4A2@57723|Acidobacteria,2JJ6J@204432|Acidobacteriia	204432|Acidobacteriia	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
TLS2_k127_3886999_9	204669.Acid345_0674	1.273e-28	123.0	2CGTB@1|root,343WT@2|Bacteria,3Y8D9@57723|Acidobacteria,2JNEN@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3886999_1	1267533.KB906735_gene5062	2.967e-242	758.0	COG1866@1|root,COG1866@2|Bacteria,3Y3U4@57723|Acidobacteria,2JKFR@204432|Acidobacteriia	204432|Acidobacteriia	C	Phosphoenolpyruvate carboxykinase	-	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
TLS2_k127_3886999_8	1267534.KB906757_gene789	8.855e-45	165.0	29UYB@1|root,30GB5@2|Bacteria,3Y4SK@57723|Acidobacteria,2JJC8@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3886999_0	671143.DAMO_1073	0.0	1082.0	COG0542@1|root,COG0542@2|Bacteria,2NNNE@2323|unclassified Bacteria	2|Bacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03694,ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS2_k127_3886999_7	1382359.JIAL01000001_gene893	3.288e-58	205.0	COG0071@1|root,COG0071@2|Bacteria,3Y4TM@57723|Acidobacteria,2JJFI@204432|Acidobacteriia	204432|Acidobacteriia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS2_k127_3886999_3	1280952.HJA_09824	1.409e-179	574.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,43W7I@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_3886999_4	204669.Acid345_4768	4.149e-142	462.0	COG1092@1|root,COG1092@2|Bacteria,3Y2PV@57723|Acidobacteria,2JICM@204432|Acidobacteriia	204432|Acidobacteriia	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TLS2_k127_3886999_11	391038.Bphy_0639	5.767e-09	68.0	COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2VJNV@28216|Betaproteobacteria,1K0WR@119060|Burkholderiaceae	28216|Betaproteobacteria	M	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
TLS2_k127_3886999_6	204669.Acid345_4769	2.953e-59	214.0	COG1579@1|root,COG1579@2|Bacteria,3Y509@57723|Acidobacteria,2JK0Q@204432|Acidobacteriia	204432|Acidobacteriia	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
TLS2_k127_3886999_5	204669.Acid345_0039	1.18e-79	271.0	COG0491@1|root,COG0491@2|Bacteria,3Y3M4@57723|Acidobacteria,2JI7X@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_3968706_12	697284.ERIC2_c16660	1.581e-05	48.0	COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,4H9T0@91061|Bacilli,26S18@186822|Paenibacillaceae	91061|Bacilli	S	2-nitropropane dioxygenase	npd	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
TLS2_k127_3968706_10	204669.Acid345_3132	7.061e-56	201.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_3968706_9	204669.Acid345_3133	1.019e-82	290.0	COG0810@1|root,COG0810@2|Bacteria,3Y4BU@57723|Acidobacteria,2JJ3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
TLS2_k127_3968706_4	706587.Desti_0542	3.991e-165	554.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42NNC@68525|delta/epsilon subdivisions,2WKQW@28221|Deltaproteobacteria,2MQ7A@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
TLS2_k127_3968706_11	204669.Acid345_1862	8.563e-44	184.0	COG0810@1|root,COG0810@2|Bacteria,3Y4BU@57723|Acidobacteria,2JJ3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
TLS2_k127_3968706_1	204669.Acid345_2369	1.123e-207	652.0	COG1960@1|root,COG1960@2|Bacteria,3Y3T6@57723|Acidobacteria,2JIV6@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3968706_6	204669.Acid345_1903	9.686e-111	365.0	COG2084@1|root,COG2084@2|Bacteria,3Y45W@57723|Acidobacteria,2JP20@204432|Acidobacteriia	204432|Acidobacteriia	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_3968706_7	204669.Acid345_1044	8.856e-107	354.0	COG2220@1|root,COG2220@2|Bacteria,3Y2TV@57723|Acidobacteria,2JHT8@204432|Acidobacteriia	204432|Acidobacteriia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_3968706_3	204669.Acid345_1043	4.622e-173	554.0	COG2379@1|root,COG2379@2|Bacteria,3Y2XC@57723|Acidobacteria,2JID2@204432|Acidobacteriia	204432|Acidobacteriia	G	MOFRL family	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
TLS2_k127_3968706_8	204669.Acid345_1042	9.044e-87	291.0	COG2945@1|root,COG2945@2|Bacteria,3Y35I@57723|Acidobacteria,2JIVZ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4
TLS2_k127_3968706_5	204669.Acid345_1040	2.083e-140	452.0	COG0624@1|root,COG0624@2|Bacteria,3Y2K0@57723|Acidobacteria,2JIEY@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM peptidase	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_3968706_0	204669.Acid345_2384	8.185e-289	904.0	COG1331@1|root,COG1331@2|Bacteria,3Y3AA@57723|Acidobacteria,2JISJ@204432|Acidobacteriia	204432|Acidobacteriia	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
TLS2_k127_3968706_2	234267.Acid_7927	4.97e-174	555.0	COG0365@1|root,COG0365@2|Bacteria,3Y39K@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_396974_2	278963.ATWD01000001_gene2176	2.291e-120	397.0	COG0451@1|root,COG0451@2|Bacteria,3Y3ZG@57723|Acidobacteria,2JHT7@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS2_k127_396974_4	1396418.BATQ01000141_gene3400	6.266e-106	359.0	COG0381@1|root,COG0381@2|Bacteria,46V5D@74201|Verrucomicrobia	74201|Verrucomicrobia	M	UDP-N-acetylglucosamine 2-epimerase	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
TLS2_k127_396974_3	272134.KB731324_gene4079	2.779e-108	367.0	COG1215@1|root,COG1215@2|Bacteria,1G3TI@1117|Cyanobacteria,1HAHR@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_396974_0	272134.KB731324_gene4078	1.671e-170	544.0	COG0399@1|root,COG0399@2|Bacteria,1G3H0@1117|Cyanobacteria,1H8TM@1150|Oscillatoriales	1117|Cyanobacteria	M	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_396974_1	272134.KB731324_gene4077	4.272e-135	447.0	COG0673@1|root,COG0673@2|Bacteria,1G0M6@1117|Cyanobacteria,1HA0M@1150|Oscillatoriales	1117|Cyanobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_396974_5	118166.JH976537_gene14	8.188e-88	298.0	COG0110@1|root,COG0110@2|Bacteria,1G65X@1117|Cyanobacteria,1H84W@1150|Oscillatoriales	1117|Cyanobacteria	S	Hexapeptide repeat of succinyl-transferase	-	-	2.3.1.201	ko:K13018	ko00520,map00520	-	R10100	RC00004,RC00166	ko00000,ko00001,ko01000,ko01005	-	-	-	Hexapep
TLS2_k127_396974_6	1411123.JQNH01000001_gene2444	3.677e-19	97.0	COG4106@1|root,COG4106@2|Bacteria,1R08A@1224|Proteobacteria,2TYN4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_3990289_4	240015.ACP_2194	1.883e-10	72.0	COG3595@1|root,COG3595@2|Bacteria,3Y5AF@57723|Acidobacteria,2JNIJ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3990289_1	204669.Acid345_1430	5.491e-52	192.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	fadB	GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K01782,ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c26730,iETEC_1333.ETEC_2476,iEcE24377_1341.EcE24377A_2637,iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200,ic_1306.c2886	3HCDH,3HCDH_N,ECH_1
TLS2_k127_3990289_2	204669.Acid345_1494	3.538e-37	161.0	COG0810@1|root,COG2203@1|root,COG0810@2|Bacteria,COG2203@2|Bacteria	2|Bacteria	T	Gaf domain	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,EAL,GAF,GAF_2,GGDEF,HATPase_c,HisKA,Hpt,Response_reg,TonB_C
TLS2_k127_3990289_0	204669.Acid345_1428	3.063e-298	923.0	COG4799@1|root,COG4799@2|Bacteria,3Y3DC@57723|Acidobacteria,2JIP2@204432|Acidobacteriia	204432|Acidobacteriia	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
TLS2_k127_3990289_3	204669.Acid345_1427	2.018e-18	85.0	COG0119@1|root,COG0119@2|Bacteria,3Y2NJ@57723|Acidobacteria,2JI67@204432|Acidobacteriia	204432|Acidobacteriia	E	HMGL-like	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS2_k127_4034065_10	234267.Acid_4386	7.547e-123	396.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
TLS2_k127_4034065_6	234267.Acid_4387	1.737e-149	477.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
TLS2_k127_4034065_19	234267.Acid_4388	1.04e-64	235.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	-	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
TLS2_k127_4034065_14	1191523.MROS_0607	4.986e-88	302.0	COG0276@1|root,COG0276@2|Bacteria	2|Bacteria	H	ferrochelatase activity	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009314,GO:0009416,GO:0009628,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0050896,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1540,iECS88_1305.ECS88_0472,iEcE24377_1341.EcE24377A_0515	Ferrochelatase
TLS2_k127_4034065_28	1183438.GKIL_1265	3.851e-08	60.0	2A3W2@1|root,30SE9@2|Bacteria,1GDAU@1117|Cyanobacteria	1117|Cyanobacteria	L	PD-(D/E)XK endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_5
TLS2_k127_4034065_26	1384056.N787_09975	3.308e-42	160.0	2CHCP@1|root,32S5R@2|Bacteria,1MZ97@1224|Proteobacteria,1S8M3@1236|Gammaproteobacteria,1XAU1@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS2_k127_4034065_4	204669.Acid345_4042	6.264e-168	534.0	COG0473@1|root,COG0473@2|Bacteria,3Y2VW@57723|Acidobacteria,2JIUD@204432|Acidobacteriia	204432|Acidobacteriia	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_4034065_16	204669.Acid345_4041	1.181e-79	269.0	COG1327@1|root,COG1327@2|Bacteria,3Y4GA@57723|Acidobacteria,2JJC7@204432|Acidobacteriia	204432|Acidobacteriia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
TLS2_k127_4034065_20	682795.AciX8_1433	1.55e-64	231.0	COG3394@1|root,COG3394@2|Bacteria,3Y441@57723|Acidobacteria,2JI4E@204432|Acidobacteriia	204432|Acidobacteriia	G	YdjC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YdjC
TLS2_k127_4034065_3	204669.Acid345_4031	1.766e-178	566.0	COG0438@1|root,COG0438@2|Bacteria,3Y3CI@57723|Acidobacteria,2JKK7@204432|Acidobacteriia	204432|Acidobacteriia	M	glycosyl transferase group 1	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_4034065_7	1267533.KB906737_gene1542	1.494e-140	459.0	COG2972@1|root,COG2972@2|Bacteria,3Y3NH@57723|Acidobacteria,2JHT4@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	5TM-5TMR_LYT,HATPase_c,His_kinase
TLS2_k127_4034065_11	204669.Acid345_4033	1.804e-119	397.0	COG0013@1|root,COG0013@2|Bacteria,3Y4AR@57723|Acidobacteria,2JJ1S@204432|Acidobacteriia	204432|Acidobacteriia	J	Threonyl and Alanyl tRNA synthetase second additional domain	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
TLS2_k127_4034065_5	204669.Acid345_4034	5.054e-156	501.0	COG0498@1|root,COG0498@2|Bacteria,3Y2GX@57723|Acidobacteria,2JHWS@204432|Acidobacteriia	204432|Acidobacteriia	E	TIGRFAM Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_4034065_18	1267534.KB906759_gene1657	9.135e-69	241.0	COG4700@1|root,COG4700@2|Bacteria,3Y7KZ@57723|Acidobacteria,2JMTS@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4034065_17	1382359.JIAL01000001_gene2626	1.845e-73	261.0	COG0628@1|root,COG0628@2|Bacteria,3Y40R@57723|Acidobacteria,2JIX8@204432|Acidobacteriia	204432|Acidobacteriia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_4034065_1	1267534.KB906756_gene22	1.76e-193	626.0	COG0531@1|root,COG0531@2|Bacteria,3Y3SZ@57723|Acidobacteria,2JI7T@204432|Acidobacteriia	204432|Acidobacteriia	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_4034065_13	204669.Acid345_4036	5.145e-97	327.0	COG0561@1|root,COG0561@2|Bacteria,3Y4J5@57723|Acidobacteria,2JJB7@204432|Acidobacteriia	204432|Acidobacteriia	S	HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
TLS2_k127_4034065_25	204669.Acid345_4037	1.187e-51	192.0	COG0741@1|root,COG0741@2|Bacteria,3Y4SM@57723|Acidobacteria,2JJJQ@204432|Acidobacteriia	204432|Acidobacteriia	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TLS2_k127_4034065_21	204669.Acid345_4038	3.224e-64	234.0	COG0392@1|root,COG0392@2|Bacteria,3Y3SG@57723|Acidobacteria,2JIIX@204432|Acidobacteriia	204432|Acidobacteriia	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS2_k127_4034065_12	204669.Acid345_1934	5.269e-114	373.0	COG0784@1|root,COG0784@2|Bacteria,3Y3G5@57723|Acidobacteria,2JI32@204432|Acidobacteriia	204432|Acidobacteriia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_4,Response_reg
TLS2_k127_4034065_9	278963.ATWD01000002_gene397	1.649e-132	432.0	COG1044@1|root,COG1044@2|Bacteria,3Y2JC@57723|Acidobacteria,2JI2Y@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
TLS2_k127_4034065_22	204669.Acid345_1936	1.717e-59	212.0	2C62N@1|root,32TCB@2|Bacteria,3Y55K@57723|Acidobacteria,2JP1N@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4034065_2	204669.Acid345_1937	2.035e-187	602.0	COG0617@1|root,COG0617@2|Bacteria,3Y3U6@57723|Acidobacteria,2JIF4@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the tRNA nucleotidyltransferase poly(A) polymerase family	-	-	-	-	-	-	-	-	-	-	-	-	PolyA_pol
TLS2_k127_4034065_27	1137271.AZUM01000003_gene3368	9.611e-32	136.0	COG0500@1|root,COG2226@2|Bacteria,2GJUF@201174|Actinobacteria,4E3Z1@85010|Pseudonocardiales	201174|Actinobacteria	Q	Mycolic acid cyclopropane synthetase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016741,GO:0022607,GO:0032259,GO:0042546,GO:0044085,GO:0044464,GO:0071554,GO:0071766,GO:0071770,GO:0071840,GO:0071944	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_4034065_24	1144275.COCOR_06243	2.504e-52	198.0	COG3000@1|root,COG3000@2|Bacteria,1NBCT@1224|Proteobacteria	1224|Proteobacteria	I	B domain of TMEM189, localisation domain	carF	-	-	ko:K20656	-	-	-	-	ko00000,ko04131	-	-	-	TMEM189_B_dmain
TLS2_k127_4034065_0	204669.Acid345_2747	0.0	1614.0	COG0587@1|root,COG0587@2|Bacteria,3Y2TS@57723|Acidobacteria,2JIA9@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA-directed DNA polymerase	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
TLS2_k127_4034065_8	204669.Acid345_2746	3.568e-140	454.0	COG0825@1|root,COG0825@2|Bacteria,3Y34D@57723|Acidobacteria,2JHNW@204432|Acidobacteriia	204432|Acidobacteriia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
TLS2_k127_4034065_23	234267.Acid_4440	3.111e-57	207.0	COG1073@1|root,COG1073@2|Bacteria,3Y91X@57723|Acidobacteria	57723|Acidobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4034065_15	886293.Sinac_7584	4.643e-87	299.0	COG0715@1|root,COG0715@2|Bacteria,2IX2Y@203682|Planctomycetes	203682|Planctomycetes	P	Protein of unknown function (DUF3500)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3500
TLS2_k127_4139861_7	204669.Acid345_0556	3.746e-44	164.0	COG0816@1|root,COG0816@2|Bacteria,3Y59A@57723|Acidobacteria,2JP2U@204432|Acidobacteriia	204432|Acidobacteriia	J	Likely ribonuclease with RNase H fold.	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
TLS2_k127_4139861_4	204669.Acid345_0553	4.961e-77	261.0	COG1329@1|root,COG1329@2|Bacteria,3Y4ZG@57723|Acidobacteria,2JMXA@204432|Acidobacteriia	204432|Acidobacteriia	K	CarD-like/TRCF domain	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
TLS2_k127_4139861_5	1382359.JIAL01000001_gene880	7.613e-73	249.0	COG0782@1|root,COG0782@2|Bacteria,3Y49X@57723|Acidobacteria,2JJ1A@204432|Acidobacteriia	204432|Acidobacteriia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TLS2_k127_4139861_3	1382359.JIAL01000001_gene879	6.645e-87	295.0	COG0558@1|root,COG0558@2|Bacteria,3Y427@57723|Acidobacteria,2JID7@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_4139861_2	1382359.JIAL01000001_gene1401	1.059e-122	411.0	COG1446@1|root,COG1446@2|Bacteria,3Y2YJ@57723|Acidobacteria,2JIZ2@204432|Acidobacteriia	204432|Acidobacteriia	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
TLS2_k127_4139861_0	401053.AciPR4_0212	4.19e-221	732.0	COG1629@1|root,COG4771@2|Bacteria,3Y77Y@57723|Acidobacteria,2JKVG@204432|Acidobacteriia	204432|Acidobacteriia	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_4139861_1	204669.Acid345_0549	1.864e-219	698.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,3Y38S@57723|Acidobacteria,2JHZB@204432|Acidobacteriia	204432|Acidobacteriia	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
TLS2_k127_4139861_8	204669.Acid345_4375	8.06e-21	95.0	2EB4K@1|root,33CHY@2|Bacteria,3Y5VG@57723|Acidobacteria,2JK6F@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4139861_6	204669.Acid345_4372	2.268e-62	224.0	COG2932@1|root,COG2932@2|Bacteria,3Y4TJ@57723|Acidobacteria,2JJFQ@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_26
TLS2_k127_4154424_0	1236501.BAJU01000023_gene2177	4.616e-61	212.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TQWP@28211|Alphaproteobacteria,2JRCE@204441|Rhodospirillales	204441|Rhodospirillales	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_4154424_1	1244869.H261_05609	3.071e-09	65.0	COG1961@1|root,COG1961@2|Bacteria,1RA63@1224|Proteobacteria,2UE33@28211|Alphaproteobacteria,2JXM1@204441|Rhodospirillales	204441|Rhodospirillales	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4185555_0	204669.Acid345_4548	2.72e-199	631.0	COG0001@1|root,COG0001@2|Bacteria,3Y3GA@57723|Acidobacteria,2JINJ@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_4185555_1	204669.Acid345_4749	5.462e-59	212.0	COG0726@1|root,COG0726@2|Bacteria,3Y4FK@57723|Acidobacteria,2JJ5K@204432|Acidobacteriia	204432|Acidobacteriia	G	polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
TLS2_k127_4185555_2	204669.Acid345_4748	6.835e-40	153.0	COG1428@1|root,COG1428@2|Bacteria,3Y759@57723|Acidobacteria,2JMB9@204432|Acidobacteriia	204432|Acidobacteriia	F	Deoxynucleoside kinase	-	-	-	-	-	-	-	-	-	-	-	-	dNK
TLS2_k127_4205526_8	1198114.AciX9_0640	2.727e-10	63.0	COG0154@1|root,COG0154@2|Bacteria,3Y3E5@57723|Acidobacteria,2JISE@204432|Acidobacteriia	204432|Acidobacteriia	J	PFAM Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
TLS2_k127_4205526_1	204669.Acid345_2300	1.394e-162	541.0	COG5316@1|root,COG5316@2|Bacteria,3Y46P@57723|Acidobacteria,2JMJ4@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
TLS2_k127_4205526_0	204669.Acid345_4697	1.015e-286	887.0	COG4799@1|root,COG4799@2|Bacteria,3Y3SM@57723|Acidobacteria,2JIBH@204432|Acidobacteriia	204432|Acidobacteriia	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_4205526_3	204669.Acid345_4694	1.254e-99	337.0	COG0611@1|root,COG0611@2|Bacteria,3Y30U@57723|Acidobacteria,2JHT0@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_4205526_2	204669.Acid345_4692	1.64e-108	359.0	COG0739@1|root,COG0739@2|Bacteria,3Y3N4@57723|Acidobacteria,2JHPR@204432|Acidobacteriia	204432|Acidobacteriia	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_4205526_10	204669.Acid345_3558	9.455e-06	53.0	COG3668@1|root,COG3668@2|Bacteria	2|Bacteria	D	Plasmid stabilization system	spsF	-	-	ko:K19092	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
TLS2_k127_4205526_4	204669.Acid345_4686	5.056e-52	197.0	28MK6@1|root,2ZAWH@2|Bacteria,3Y30X@57723|Acidobacteria,2JITA@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4205526_5	204669.Acid345_4685	4.696e-24	108.0	COG0801@1|root,COG0801@2|Bacteria,3Y5HK@57723|Acidobacteria,2JJYV@204432|Acidobacteriia	204432|Acidobacteriia	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4205526_6	234267.Acid_5120	1.933e-20	90.0	COG0050@1|root,COG0050@2|Bacteria,3Y2JG@57723|Acidobacteria	57723|Acidobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TLS2_k127_4228465_5	1121920.AUAU01000027_gene1480	2.264e-73	268.0	COG0457@1|root,COG0457@2|Bacteria	1121920.AUAU01000027_gene1480|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4228465_4	56780.SYN_00856	2.035e-117	393.0	COG1215@1|root,COG1215@2|Bacteria,1MXG7@1224|Proteobacteria,42MRD@68525|delta/epsilon subdivisions,2X5MW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
TLS2_k127_4228465_6	684949.ATTJ01000001_gene697	0.0001444	55.0	COG1413@1|root,COG1413@2|Bacteria,1WIXV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
TLS2_k127_4228465_3	247639.MGP2080_11863	5.068e-122	405.0	COG1680@1|root,COG1680@2|Bacteria,1NHIY@1224|Proteobacteria,1S719@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_4228465_1	204669.Acid345_1532	2.694e-179	572.0	COG0160@1|root,COG0160@2|Bacteria,3Y4EV@57723|Acidobacteria,2JKID@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
TLS2_k127_4228465_0	221288.JH992901_gene2720	8.153e-203	644.0	COG1012@1|root,COG1012@2|Bacteria,1G09W@1117|Cyanobacteria,1JHZW@1189|Stigonemataceae	1117|Cyanobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_4228465_2	1121422.AUMW01000012_gene2929	3.449e-139	457.0	COG0833@1|root,COG0833@2|Bacteria,1UHPU@1239|Firmicutes,25E64@186801|Clostridia	186801|Clostridia	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
TLS2_k127_4252806_2	1158294.JOMI01000003_gene2714	0.0004547	51.0	COG3678@1|root,COG3678@2|Bacteria,4NYJD@976|Bacteroidetes,2FX34@200643|Bacteroidia	976|Bacteroidetes	NPTU	ATP-independent chaperone mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4252806_0	204669.Acid345_1454	4e-323	997.0	COG1884@1|root,COG1884@2|Bacteria,3Y2PQ@57723|Acidobacteria,2JHJN@204432|Acidobacteriia	204432|Acidobacteriia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS2_k127_4252806_1	1382359.JIAL01000001_gene2751	1.128e-49	180.0	COG0463@1|root,COG0463@2|Bacteria,3Y34G@57723|Acidobacteria,2JIGQ@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_4276188_3	204669.Acid345_3782	2.212e-110	364.0	COG1660@1|root,COG1660@2|Bacteria,3Y2HM@57723|Acidobacteria,2JHJM@204432|Acidobacteriia	204432|Acidobacteriia	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
TLS2_k127_4276188_6	1267533.KB906740_gene119	9.996e-12	70.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
TLS2_k127_4276188_4	247490.KSU1_D0154	2.942e-71	252.0	COG1226@1|root,2ZCE6@2|Bacteria	2|Bacteria	P	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2
TLS2_k127_4276188_5	204669.Acid345_1670	9.682e-67	234.0	COG1544@1|root,COG1544@2|Bacteria,3Y533@57723|Acidobacteria,2JJE9@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal subunit interface protein	-	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
TLS2_k127_4276188_1	240015.ACP_0621	6.161e-184	593.0	COG1508@1|root,COG1508@2|Bacteria,3Y2M0@57723|Acidobacteria,2JIY6@204432|Acidobacteriia	204432|Acidobacteriia	K	RNA polymerase sigma-54 factor	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
TLS2_k127_4276188_2	204669.Acid345_1661	1.915e-132	424.0	COG1137@1|root,COG1137@2|Bacteria,3Y2MC@57723|Acidobacteria,2JHPV@204432|Acidobacteriia	204432|Acidobacteriia	S	ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_4276188_0	204669.Acid345_1660	1.149e-192	625.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC,OstA
TLS2_k127_4281791_1	204669.Acid345_2290	1.044e-74	254.0	COG3383@1|root,COG3383@2|Bacteria	2|Bacteria	C	formate dehydrogenase (NAD+) activity	-	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS03470	Fer2_4,Fer4,Fer4_21,Fer4_7
TLS2_k127_4281791_0	204669.Acid345_2291	9.895e-230	720.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,3Y47M@57723|Acidobacteria,2JKQK@204432|Acidobacteriia	204432|Acidobacteriia	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
TLS2_k127_4298710_0	627192.SLG_18220	7.177e-55	213.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2TTTV@28211|Alphaproteobacteria,2K296@204457|Sphingomonadales	204457|Sphingomonadales	E	alpha/beta hydrolase fold	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_4338985_0	1123073.KB899241_gene2664	3.552e-112	373.0	2BSEF@1|root,32MGE@2|Bacteria,1N9VN@1224|Proteobacteria,1SG8G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4338985_1	1535422.ND16A_1887	3.371e-97	325.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,1RQ1A@1236|Gammaproteobacteria,2Q6Q9@267889|Colwelliaceae	1236|Gammaproteobacteria	M	PFAM membrane bound O-acyl transferase MBOAT family protein	patA	-	-	-	-	-	-	-	-	-	-	-	MBOAT
TLS2_k127_4365221_7	639030.JHVA01000001_gene1825	3.444e-25	105.0	2C987@1|root,331JK@2|Bacteria,3Y5R0@57723|Acidobacteria,2JK28@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4365221_9	66692.ABC0726	5.087e-09	64.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UI6B@1239|Firmicutes,4ISFD@91061|Bacilli,1ZHJV@1386|Bacillus	91061|Bacilli	T	cheY-homologous receiver domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
TLS2_k127_4365221_1	204669.Acid345_1335	3.765e-154	512.0	COG0840@1|root,COG2208@1|root,COG0840@2|Bacteria,COG2208@2|Bacteria,3Y2P9@57723|Acidobacteria,2JIVP@204432|Acidobacteriia	204432|Acidobacteriia	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
TLS2_k127_4365221_2	204669.Acid345_1181	1.412e-88	298.0	COG2930@1|root,COG2930@2|Bacteria,3Y4GG@57723|Acidobacteria,2JKH3@204432|Acidobacteriia	204432|Acidobacteriia	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
TLS2_k127_4365221_5	1198114.AciX9_1850	4.355e-34	142.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,KAP_NTPase,PAS_4,Response_reg,TIR_2,Trans_reg_C
TLS2_k127_4365221_0	518766.Rmar_1790	4.43e-157	509.0	COG1228@1|root,COG1228@2|Bacteria,4NEV0@976|Bacteroidetes	976|Bacteroidetes	Q	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_4365221_6	1174528.JH992898_gene5232	8.904e-34	152.0	2E8PN@1|root,3330T@2|Bacteria,1GFR6@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4365221_8	1348657.M622_01565	6.242e-16	93.0	2BUI5@1|root,32PUE@2|Bacteria,1RHFT@1224|Proteobacteria,2VT0W@28216|Betaproteobacteria,2KZHV@206389|Rhodocyclales	206389|Rhodocyclales	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4365221_4	522306.CAP2UW1_2220	1.853e-74	285.0	2BVDD@1|root,32QTC@2|Bacteria,1NR8F@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
TLS2_k127_4365221_10	1122194.AUHU01000002_gene2690	4.875e-08	67.0	COG0810@1|root,COG3266@1|root,COG3291@1|root,COG0810@2|Bacteria,COG3266@2|Bacteria,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1T46G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	REJ
TLS2_k127_4365221_3	1267534.KB906755_gene4695	1.45e-75	263.0	COG1629@1|root,COG4771@2|Bacteria,3Y33S@57723|Acidobacteria,2JK9M@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_439375_17	204669.Acid345_3862	0.0006358	51.0	COG1386@1|root,COG1386@2|Bacteria,3Y3E0@57723|Acidobacteria,2JHVE@204432|Acidobacteriia	204432|Acidobacteriia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
TLS2_k127_439375_3	204669.Acid345_3861	1.864e-107	355.0	COG1354@1|root,COG1354@2|Bacteria,3Y458@57723|Acidobacteria,2JIGP@204432|Acidobacteriia	204432|Acidobacteriia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
TLS2_k127_439375_0	204669.Acid345_3860	6.509e-157	513.0	COG0180@1|root,COG0180@2|Bacteria,3Y2VN@57723|Acidobacteria,2JHXI@204432|Acidobacteriia	204432|Acidobacteriia	J	aminoacyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS2_k127_439375_12	204669.Acid345_3859	2.083e-54	198.0	COG1994@1|root,COG1994@2|Bacteria,3Y58P@57723|Acidobacteria,2JJUI@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
TLS2_k127_439375_5	682795.AciX8_2533	4.496e-101	337.0	COG0110@1|root,COG0110@2|Bacteria,3Y5D1@57723|Acidobacteria,2JJP0@204432|Acidobacteriia	204432|Acidobacteriia	S	maltose O-acetyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_439375_1	204669.Acid345_3857	3.187e-154	518.0	COG2982@1|root,COG2982@2|Bacteria,3Y3Z4@57723|Acidobacteria,2JIBU@204432|Acidobacteriia	204432|Acidobacteriia	M	AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
TLS2_k127_439375_6	204669.Acid345_3856	9.684e-91	305.0	COG0681@1|root,COG0681@2|Bacteria,3Y40D@57723|Acidobacteria,2JHWM@204432|Acidobacteriia	204432|Acidobacteriia	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS2_k127_439375_9	204669.Acid345_3855	3.591e-63	226.0	COG0681@1|root,COG0681@2|Bacteria,3Y4RW@57723|Acidobacteria,2JJ8A@204432|Acidobacteriia	204432|Acidobacteriia	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS2_k127_439375_8	204669.Acid345_3854	1.413e-69	250.0	COG0571@1|root,COG0571@2|Bacteria,3Y4M2@57723|Acidobacteria,2JJ95@204432|Acidobacteriia	204432|Acidobacteriia	K	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
TLS2_k127_439375_13	204669.Acid345_3853	6.435e-49	186.0	COG0457@1|root,COG0457@2|Bacteria,3Y5WJ@57723|Acidobacteria,2JNSM@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_439375_2	204669.Acid345_3852	1.307e-115	390.0	COG0457@1|root,COG0457@2|Bacteria,3Y2IP@57723|Acidobacteria,2JHII@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
TLS2_k127_439375_10	204669.Acid345_3851	2.342e-60	220.0	COG5662@1|root,COG5662@2|Bacteria,3Y4JS@57723|Acidobacteria,2JJ7U@204432|Acidobacteriia	204432|Acidobacteriia	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_439375_7	204669.Acid345_3850	1.55e-83	285.0	COG1595@1|root,COG1595@2|Bacteria,3Y4IW@57723|Acidobacteria,2JJ89@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_439375_15	204669.Acid345_3849	6.018e-27	117.0	291MF@1|root,2ZP7P@2|Bacteria,3Y8T0@57723|Acidobacteria,2JNVR@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_439375_4	204669.Acid345_3848	2.719e-104	353.0	COG3511@1|root,COG3511@2|Bacteria,3Y5AE@57723|Acidobacteria,2JJUM@204432|Acidobacteriia	204432|Acidobacteriia	M	Phosphoesterase family	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
TLS2_k127_439375_11	204669.Acid345_0366	1.119e-54	201.0	COG0845@1|root,COG0845@2|Bacteria,3Y2FV@57723|Acidobacteria,2JHN2@204432|Acidobacteriia	204432|Acidobacteriia	M	MFP subunit	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
TLS2_k127_4416109_2	204669.Acid345_2793	5.165e-154	497.0	COG0436@1|root,COG0436@2|Bacteria,3Y2TF@57723|Acidobacteria,2JHQX@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Aminotransferase, class I	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_4416109_9	278963.ATWD01000001_gene2439	3.763e-52	191.0	COG2010@1|root,COG2010@2|Bacteria,3Y650@57723|Acidobacteria,2JKDC@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_CBB3,Paired_CXXCH_1
TLS2_k127_4416109_13	1156937.MFUM_940020	6.512e-09	61.0	28T88@1|root,2ZFGX@2|Bacteria,46Z1A@74201|Verrucomicrobia,37H1B@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4416109_5	234267.Acid_5386	8.804e-137	449.0	COG2264@1|root,COG2264@2|Bacteria,3Y3UA@57723|Acidobacteria	57723|Acidobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS2_k127_4416109_10	234267.Acid_5387	2.905e-45	184.0	COG3119@1|root,COG3119@2|Bacteria,3Y5BN@57723|Acidobacteria	57723|Acidobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_4416109_1	357804.Ping_3708	4.697e-159	520.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,2QJ8J@267894|Psychromonadaceae	1236|Gammaproteobacteria	V	MacB-like periplasmic core domain	VP1997	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_4416109_4	1485544.JQKP01000002_gene1415	5.574e-138	462.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2VIIH@28216|Betaproteobacteria,44V5Z@713636|Nitrosomonadales	28216|Betaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_4416109_8	1485544.JQKP01000002_gene1414	2.475e-92	309.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VJBY@28216|Betaproteobacteria,44VNJ@713636|Nitrosomonadales	28216|Betaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4416109_6	472759.Nhal_3354	3.803e-122	404.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1WXMI@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3,HlyD_D23
TLS2_k127_4416109_0	204669.Acid345_0770	2.962e-255	809.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_16,TPR_2,TPR_8
TLS2_k127_4416109_12	671143.DAMO_2063	2.137e-22	103.0	COG3824@1|root,COG3824@2|Bacteria,2NPZF@2323|unclassified Bacteria	2|Bacteria	S	Zincin-like metallopeptidase	MA20_43655	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Zincin_1
TLS2_k127_4416109_11	479434.Sthe_2391	1.085e-40	158.0	COG3467@1|root,COG3467@2|Bacteria,2G94U@200795|Chloroflexi	200795|Chloroflexi	S	PFAM pyridoxamine 5'-phosphate oxidase-related	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_4416109_3	204669.Acid345_0693	3.119e-152	488.0	COG0407@1|root,COG0407@2|Bacteria,3Y44R@57723|Acidobacteria,2JHPI@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS2_k127_4416109_7	204669.Acid345_0694	2.24e-107	359.0	COG0276@1|root,COG0276@2|Bacteria,3Y3B0@57723|Acidobacteria,2JHKQ@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
TLS2_k127_4438086_3	240015.ACP_2346	4.062e-61	213.0	COG0173@1|root,COG0173@2|Bacteria,3Y3SP@57723|Acidobacteria,2JIRC@204432|Acidobacteriia	204432|Acidobacteriia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_2,tRNA_anti-codon
TLS2_k127_4438086_4	926569.ANT_07230	1.878e-34	137.0	COG4577@1|root,COG4577@2|Bacteria	2|Bacteria	CQ	ethanolamine catabolic process	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
TLS2_k127_4438086_1	234267.Acid_0382	1.033e-153	507.0	COG1012@1|root,COG1012@2|Bacteria,3Y3MS@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde dehydrogenase family	-	-	1.1.1.1,1.2.1.10,1.2.1.81	ko:K04072,ko:K15515	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh,Fe-ADH
TLS2_k127_4438086_2	204669.Acid345_4173	2.058e-64	224.0	2CK48@1|root,32SBJ@2|Bacteria,3Y5FB@57723|Acidobacteria,2JJMQ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4438086_0	204669.Acid345_4172	1.184e-215	685.0	COG0608@1|root,COG0608@2|Bacteria,3Y3HI@57723|Acidobacteria,2JICS@204432|Acidobacteriia	204432|Acidobacteriia	L	single-stranded-DNA-specific exonuclease RecJ	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TLS2_k127_4438086_5	1158762.KB898040_gene1408	1.911e-33	137.0	COG1714@1|root,COG1714@2|Bacteria,1N1XF@1224|Proteobacteria,1SDY3@1236|Gammaproteobacteria,1WZR8@135613|Chromatiales	135613|Chromatiales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD,zinc_ribbon_2
TLS2_k127_4438086_6	1123504.JQKD01000002_gene3652	4.98e-09	65.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	pcbD	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_4448678_39	204669.Acid345_4277	3.717e-09	58.0	COG0457@1|root,COG0457@2|Bacteria	204669.Acid345_4277|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4448678_28	204669.Acid345_4278	2.709e-55	205.0	COG2208@1|root,COG2208@2|Bacteria,3Y85S@57723|Acidobacteria,2JN9Q@204432|Acidobacteriia	204432|Acidobacteriia	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
TLS2_k127_4448678_2	760117.JN27_01595	8.931e-203	647.0	COG0457@1|root,COG0457@2|Bacteria,1Q3YA@1224|Proteobacteria,2WBF8@28216|Betaproteobacteria,475PG@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Peptidase family M49	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M49
TLS2_k127_4448678_19	204669.Acid345_4225	7.778e-102	346.0	COG0760@1|root,COG0760@2|Bacteria,3Y3V9@57723|Acidobacteria,2JICA@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
TLS2_k127_4448678_36	1123073.KB899242_gene1520	2.217e-26	115.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	4.4.1.3,5.3.3.19	ko:K16953,ko:K19547	ko00920,ko01130,map00920,map01130	M00787	R02574	RC00747,RC00748	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Arg_Hydrox,Cupin_1,Cupin_2
TLS2_k127_4448678_34	204669.Acid345_3069	1.963e-31	124.0	COG0162@1|root,COG0162@2|Bacteria,3Y2NC@57723|Acidobacteria,2JHYA@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TLS2_k127_4448678_33	1382359.JIAL01000001_gene1530	3.63e-32	132.0	COG0162@1|root,COG0162@2|Bacteria,3Y2NC@57723|Acidobacteria,2JHYA@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TLS2_k127_4448678_17	1267534.KB906756_gene350	1.981e-111	388.0	COG0457@1|root,COG3710@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,3Y2YM@57723|Acidobacteria,2JKAC@204432|Acidobacteriia	204432|Acidobacteriia	K	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8,Trans_reg_C
TLS2_k127_4448678_10	204669.Acid345_4294	1.975e-150	482.0	COG3481@1|root,COG3481@2|Bacteria,3Y38F@57723|Acidobacteria,2JITD@204432|Acidobacteriia	204432|Acidobacteriia	S	Nucleic acid binding	-	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
TLS2_k127_4448678_40	298654.FraEuI1c_2042	1.922e-05	55.0	COG3682@1|root,COG3682@2|Bacteria,2IN7H@201174|Actinobacteria	201174|Actinobacteria	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
TLS2_k127_4448678_29	204669.Acid345_4293	4.375e-46	181.0	COG2823@1|root,COG2823@2|Bacteria,3Y99E@57723|Acidobacteria,2JP08@204432|Acidobacteriia	204432|Acidobacteriia	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4448678_23	1487953.JMKF01000077_gene4068	4.222e-76	262.0	COG1011@1|root,COG1011@2|Bacteria,1G4JI@1117|Cyanobacteria,1H8VT@1150|Oscillatoriales	1117|Cyanobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_4448678_24	204669.Acid345_4291	5.037e-73	256.0	COG2204@1|root,COG2204@2|Bacteria,3Y3P6@57723|Acidobacteria,2JIHX@204432|Acidobacteriia	204432|Acidobacteriia	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_4448678_15	204669.Acid345_4290	4.955e-123	398.0	COG2197@1|root,COG2197@2|Bacteria,3Y669@57723|Acidobacteria,2JP3W@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_4448678_8	204669.Acid345_4289	1.581e-163	531.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,3Y59R@57723|Acidobacteria,2JNHF@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_4448678_5	204669.Acid345_4288	7.232e-185	589.0	COG0082@1|root,COG0082@2|Bacteria,3Y2Z8@57723|Acidobacteria,2JINW@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
TLS2_k127_4448678_22	204669.Acid345_4287	3.283e-78	264.0	COG0242@1|root,COG0242@2|Bacteria,3Y4HY@57723|Acidobacteria,2JJ9D@204432|Acidobacteriia	204432|Acidobacteriia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TLS2_k127_4448678_14	204669.Acid345_4228	1.563e-127	414.0	COG0223@1|root,COG0223@2|Bacteria,3Y32C@57723|Acidobacteria,2JHUK@204432|Acidobacteriia	204432|Acidobacteriia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TLS2_k127_4448678_12	204669.Acid345_4229	1.974e-142	466.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,3Y2NW@57723|Acidobacteria,2JHNM@204432|Acidobacteriia	204432|Acidobacteriia	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
TLS2_k127_4448678_27	204669.Acid345_4230	6.799e-58	210.0	COG2815@1|root,COG2815@2|Bacteria,3Y4UG@57723|Acidobacteria,2JJF0@204432|Acidobacteriia	204432|Acidobacteriia	S	PASTA domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA
TLS2_k127_4448678_30	1267535.KB906767_gene1065	2.045e-44	166.0	COG1970@1|root,COG1970@2|Bacteria,3Y58F@57723|Acidobacteria,2JJRP@204432|Acidobacteriia	204432|Acidobacteriia	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
TLS2_k127_4448678_0	204669.Acid345_4231	1.765e-287	904.0	COG5009@1|root,COG5009@2|Bacteria,3Y31C@57723|Acidobacteria,2JHJY@204432|Acidobacteriia	204432|Acidobacteriia	M	Penicillin-binding protein 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS2_k127_4448678_9	204669.Acid345_4232	3.795e-154	498.0	COG0793@1|root,COG0793@2|Bacteria,3Y3A7@57723|Acidobacteria,2JHJK@204432|Acidobacteriia	204432|Acidobacteriia	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
TLS2_k127_4448678_35	1195246.AGRI_04461	1.831e-27	129.0	COG2199@1|root,COG3706@2|Bacteria,1NECV@1224|Proteobacteria,1S1ZR@1236|Gammaproteobacteria,46766@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG2199 FOG GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,GGDEF,HAMP
TLS2_k127_4448678_31	1379698.RBG1_1C00001G0253	2.009e-41	173.0	COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
TLS2_k127_4448678_3	96561.Dole_1094	3.64e-192	617.0	COG0471@1|root,COG0490@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2MMR4@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
TLS2_k127_4448678_20	204669.Acid345_0573	7.734e-98	325.0	COG1212@1|root,COG1212@2|Bacteria,3Y4GZ@57723|Acidobacteria,2JHK0@204432|Acidobacteriia	204432|Acidobacteriia	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
TLS2_k127_4448678_37	861299.J421_5899	5.924e-20	104.0	COG0457@1|root,COG0823@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K03641,ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001,ko02000	2.C.1.2	-	-	DUF4214,Pkinase,SBBP,TPR_16,TPR_19,TPR_2,TPR_8
TLS2_k127_4448678_13	204669.Acid345_0572	1.231e-138	451.0	COG0501@1|root,COG0501@2|Bacteria,3Y2PP@57723|Acidobacteria,2JI24@204432|Acidobacteriia	2|Bacteria	O	Peptidase M48	agmM	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
TLS2_k127_4448678_4	204669.Acid345_0571	1.468e-187	597.0	COG1109@1|root,COG1109@2|Bacteria,3Y2F7@57723|Acidobacteria,2JHIV@204432|Acidobacteriia	204432|Acidobacteriia	G	alpha beta alpha domain I	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_4448678_11	204669.Acid345_0570	1.998e-148	477.0	COG0836@1|root,COG0836@2|Bacteria,3Y2W2@57723|Acidobacteria,2JI4D@204432|Acidobacteriia	204432|Acidobacteriia	M	mannose-6-phosphate isomerase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
TLS2_k127_4448678_16	204669.Acid345_0569	1.47e-114	382.0	COG1482@1|root,COG1482@2|Bacteria,3Y44Q@57723|Acidobacteria,2JIZ8@204432|Acidobacteriia	204432|Acidobacteriia	G	Phosphomannose isomerase type I	-	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
TLS2_k127_4448678_7	204669.Acid345_0568	3.375e-176	571.0	COG0436@1|root,COG0436@2|Bacteria,3Y2IZ@57723|Acidobacteria,2JHUI@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Aminotransferase, class I	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_4448678_25	204669.Acid345_0567	7.791e-69	237.0	COG0669@1|root,COG0669@2|Bacteria,3Y4B6@57723|Acidobacteria,2JJ6A@204432|Acidobacteriia	204432|Acidobacteriia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_4448678_26	745411.B3C1_00465	2.899e-60	229.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1J8B4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	COG1404 Subtilisin-like serine proteases	-	-	-	-	-	-	-	-	-	-	-	-	PA,PKD,Peptidase_S8
TLS2_k127_4448678_6	240015.ACP_3307	2.001e-181	573.0	COG0468@1|root,COG0468@2|Bacteria,3Y3Y1@57723|Acidobacteria,2JHU1@204432|Acidobacteriia	204432|Acidobacteriia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TLS2_k127_4448678_38	491916.RHECIAT_CH0000919	4.388e-15	89.0	COG2161@1|root,COG2161@2|Bacteria,1NBSZ@1224|Proteobacteria,2UH86@28211|Alphaproteobacteria,4BG1P@82115|Rhizobiaceae	28211|Alphaproteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS2_k127_4448678_32	1040989.AWZU01000010_gene4207	1.481e-39	151.0	COG1487@1|root,COG1487@2|Bacteria,1RIB5@1224|Proteobacteria,2VGZ3@28211|Alphaproteobacteria,3JZA4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
TLS2_k127_4448678_1	204669.Acid345_4490	4.036e-211	668.0	COG1351@1|root,COG1351@2|Bacteria,3Y3AY@57723|Acidobacteria,2JHXW@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
TLS2_k127_4448678_21	204669.Acid345_4491	1.452e-87	308.0	COG3361@1|root,COG3361@2|Bacteria,3Y4D9@57723|Acidobacteria,2JJ5H@204432|Acidobacteriia	204432|Acidobacteriia	S	Uncharacterized conserved protein (COG2071)	-	-	-	ko:K09166	-	-	-	-	ko00000	-	-	-	DUF2071
TLS2_k127_4448678_18	518766.Rmar_0400	1.733e-104	365.0	COG1524@1|root,COG1524@2|Bacteria,4NFFG@976|Bacteroidetes,1FJY0@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phosphodiest
TLS2_k127_4471210_5	234267.Acid_7393	1.405e-19	91.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
TLS2_k127_4471210_2	1382359.JIAL01000001_gene1488	7.975e-114	381.0	COG1816@1|root,COG1816@2|Bacteria,3Y2R0@57723|Acidobacteria,2JINF@204432|Acidobacteriia	204432|Acidobacteriia	F	Adenosine/AMP deaminase	-	-	3.5.4.4,3.5.4.40	ko:K01488,ko:K18286	ko00130,ko00230,ko01100,ko01110,ko05340,map00130,map00230,map01100,map01110,map05340	-	R01560,R02556,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
TLS2_k127_4471210_1	266117.Rxyl_2944	2.765e-153	497.0	COG0644@1|root,COG0644@2|Bacteria,2GJDF@201174|Actinobacteria,4CQKV@84995|Rubrobacteria	84995|Rubrobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS2_k127_4471210_3	196367.JNFG01000199_gene3755	1.241e-112	373.0	COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,2VJ1S@28216|Betaproteobacteria,1K1WG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_4471210_4	639030.JHVA01000001_gene2647	4.326e-42	165.0	2BRBT@1|root,32KAC@2|Bacteria,3Y4U0@57723|Acidobacteria,2JJJP@204432|Acidobacteriia	204432|Acidobacteriia	S	Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
TLS2_k127_4471210_0	1382359.JIAL01000001_gene908	0.0	1243.0	COG0188@1|root,COG0188@2|Bacteria,3Y2G5@57723|Acidobacteria,2JIR8@204432|Acidobacteriia	204432|Acidobacteriia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS2_k127_4474312_23	1122997.AUDD01000005_gene1824	8.278e-11	70.0	COG0008@1|root,COG0008@2|Bacteria,2H1TZ@201174|Actinobacteria	201174|Actinobacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
TLS2_k127_4474312_6	240015.ACP_1615	3.866e-169	548.0	COG0008@1|root,COG0008@2|Bacteria,3Y465@57723|Acidobacteria,2JHZW@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS2_k127_4474312_0	204669.Acid345_0185	0.0	1077.0	COG2199@1|root,COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3706@2|Bacteria,3Y40V@57723|Acidobacteria,2JI0P@204432|Acidobacteriia	2|Bacteria	T	diguanylate cyclase	-	-	-	ko:K02030,ko:K06950,ko:K16923	-	M00236,M00582	-	-	ko00000,ko00002,ko02000	3.A.1.28,3.A.1.3	-	-	GGDEF,HD,HD_5,HisKA_3,Reg_prop,Y_Y_Y
TLS2_k127_4474312_1	639030.JHVA01000001_gene1313	2.66e-219	704.0	COG2866@1|root,COG2866@2|Bacteria,3Y3P5@57723|Acidobacteria,2JHWK@204432|Acidobacteriia	204432|Acidobacteriia	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS2_k127_4474312_15	240015.ACP_1616	1.509e-62	220.0	COG0245@1|root,COG0245@2|Bacteria,3Y3WG@57723|Acidobacteria,2JIXW@204432|Acidobacteriia	204432|Acidobacteriia	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
TLS2_k127_4474312_13	204669.Acid345_0188	2.954e-85	290.0	COG1211@1|root,COG1211@2|Bacteria,3Y3VR@57723|Acidobacteria,2JI25@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
TLS2_k127_4474312_8	204669.Acid345_0189	1.187e-163	521.0	COG4956@1|root,COG4956@2|Bacteria,3Y2RT@57723|Acidobacteria,2JKNZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Large family of predicted nucleotide-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
TLS2_k127_4474312_18	204669.Acid345_0154	2.85e-49	182.0	COG4770@1|root,COG4770@2|Bacteria,3Y5QJ@57723|Acidobacteria,2JN6E@204432|Acidobacteriia	204432|Acidobacteriia	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
TLS2_k127_4474312_2	204669.Acid345_0153	1.032e-213	674.0	COG0439@1|root,COG0439@2|Bacteria,3Y3FH@57723|Acidobacteria,2JKRD@204432|Acidobacteriia	204432|Acidobacteriia	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TLS2_k127_4474312_14	204669.Acid345_0152	3.294e-83	284.0	COG0457@1|root,COG0457@2|Bacteria,3Y3N5@57723|Acidobacteria,2JISD@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
TLS2_k127_4474312_19	204669.Acid345_0151	9.536e-33	133.0	COG0848@1|root,COG0848@2|Bacteria,3Y5AP@57723|Acidobacteria,2JJQV@204432|Acidobacteriia	204432|Acidobacteriia	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS2_k127_4474312_17	204669.Acid345_0151	4.199e-51	184.0	COG0848@1|root,COG0848@2|Bacteria,3Y5AP@57723|Acidobacteria,2JJQV@204432|Acidobacteriia	204432|Acidobacteriia	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS2_k127_4474312_16	204669.Acid345_0150	7.058e-53	192.0	COG0848@1|root,COG0848@2|Bacteria,3Y4TE@57723|Acidobacteria,2JJKY@204432|Acidobacteriia	204432|Acidobacteriia	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS2_k127_4474312_11	204669.Acid345_0149	5.583e-103	340.0	COG0811@1|root,COG0811@2|Bacteria,3Y2M4@57723|Acidobacteria,2JI9T@204432|Acidobacteriia	204432|Acidobacteriia	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
TLS2_k127_4474312_12	204669.Acid345_0148	4.223e-96	320.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria,2JI38@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TLS2_k127_4474312_9	204669.Acid345_0147	3.939e-121	401.0	COG0341@1|root,COG0341@2|Bacteria,3Y2ZT@57723|Acidobacteria,2JHZF@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_4474312_5	204669.Acid345_0146	4.678e-194	619.0	COG0342@1|root,COG0342@2|Bacteria,3Y37S@57723|Acidobacteria,2JHJC@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_4474312_21	204669.Acid345_0145	6.676e-24	104.0	COG1862@1|root,COG1862@2|Bacteria,3Y5GK@57723|Acidobacteria,2JJW1@204432|Acidobacteriia	204432|Acidobacteriia	U	Preprotein translocase, YajC	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TLS2_k127_4474312_7	204669.Acid345_0144	4.021e-164	525.0	COG0343@1|root,COG0343@2|Bacteria,3Y3CP@57723|Acidobacteria,2JISV@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
TLS2_k127_4474312_22	1380394.JADL01000013_gene701	1.089e-15	85.0	COG5496@1|root,COG5496@2|Bacteria,1RKFT@1224|Proteobacteria,2U5DE@28211|Alphaproteobacteria,2JUSB@204441|Rhodospirillales	204441|Rhodospirillales	S	Thioesterase	-	-	3.1.2.29	ko:K18700	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
TLS2_k127_4474312_20	204669.Acid345_0097	1.747e-25	112.0	2DNWY@1|root,32UJU@2|Bacteria,3Y584@57723|Acidobacteria,2JJRR@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF2393)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2393
TLS2_k127_4474312_24	1382359.JIAL01000001_gene506	1.344e-10	72.0	2DNWY@1|root,32UJU@2|Bacteria,3Y584@57723|Acidobacteria,2JJRR@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF2393)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2393
TLS2_k127_4474312_10	1173026.Glo7428_3832	5.695e-113	383.0	COG2199@1|root,COG2202@1|root,COG2203@1|root,COG3829@1|root,COG5278@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,COG3829@2|Bacteria,COG5278@2|Bacteria,1FZWU@1117|Cyanobacteria	1117|Cyanobacteria	T	Diguanylate cyclase with PAS PAC and GAF sensors	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF,GAF_2,GAF_3,GGDEF,PAS,PAS_3,PAS_4,PAS_9
TLS2_k127_4474312_3	204669.Acid345_4760	2.111e-203	643.0	COG0312@1|root,COG0312@2|Bacteria,3Y39N@57723|Acidobacteria,2JIHC@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS2_k127_4474312_4	682795.AciX8_4617	1.671e-202	638.0	COG0312@1|root,COG0312@2|Bacteria,3Y2TY@57723|Acidobacteria,2JI8B@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS2_k127_4479330_3	204669.Acid345_2204	9.698e-10	59.0	COG0705@1|root,COG0705@2|Bacteria,3Y5A9@57723|Acidobacteria,2JNBE@204432|Acidobacteriia	204432|Acidobacteriia	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS2_k127_4479330_0	204669.Acid345_2208	1.325e-83	293.0	COG0302@1|root,COG0302@2|Bacteria,3Y2SP@57723|Acidobacteria,2JIR1@204432|Acidobacteriia	204432|Acidobacteriia	H	TIGRFAM GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
TLS2_k127_4479330_1	204669.Acid345_2212	9.742e-49	181.0	COG0526@1|root,COG0526@2|Bacteria,3Y4UN@57723|Acidobacteria,2JJGM@204432|Acidobacteriia	204432|Acidobacteriia	CO	PFAM Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_4479330_2	1121949.AQXT01000002_gene2872	5.832e-13	68.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,43WH9@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	COG2217 Cation transport ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
TLS2_k127_4484267_1	204669.Acid345_0060	5.435e-95	317.0	COG1484@1|root,COG1484@2|Bacteria,3Y3EK@57723|Acidobacteria,2JI9M@204432|Acidobacteriia	204432|Acidobacteriia	L	IstB-like ATP binding protein	-	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
TLS2_k127_4484267_2	1382356.JQMP01000003_gene1502	5.774e-43	163.0	COG0801@1|root,COG0801@2|Bacteria,2G6YT@200795|Chloroflexi,27YCY@189775|Thermomicrobia	189775|Thermomicrobia	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	-	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
TLS2_k127_4484267_3	204669.Acid345_0082	9.356e-35	147.0	COG0776@1|root,COG0776@2|Bacteria,3Y5E1@57723|Acidobacteria,2JJN0@204432|Acidobacteriia	204432|Acidobacteriia	L	Bacterial DNA-binding protein	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_4484267_4	234267.Acid_5364	1.262e-32	135.0	2EGFY@1|root,30MEN@2|Bacteria,3Y7VF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4484267_0	204669.Acid345_1826	3.112e-151	491.0	COG1228@1|root,COG1228@2|Bacteria,3Y47R@57723|Acidobacteria,2JMEC@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_4534851_0	795359.TOPB45_1499	1.447e-91	317.0	COG1004@1|root,COG1004@2|Bacteria,2GGQN@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS2_k127_4546343_2	234267.Acid_0498	6.652e-191	607.0	COG0843@1|root,COG0843@2|Bacteria,3Y2X6@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS2_k127_4546343_3	204669.Acid345_2996	2.005e-130	430.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,3Y2GR@57723|Acidobacteria,2JHRF@204432|Acidobacteriia	204432|Acidobacteriia	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
TLS2_k127_4546343_6	234267.Acid_0496	3.932e-88	299.0	COG1999@1|root,COG1999@2|Bacteria,3Y3XH@57723|Acidobacteria	57723|Acidobacteria	S	signal sequence binding	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
TLS2_k127_4546343_12	1340493.JNIF01000004_gene147	7.134e-16	85.0	2EJZ3@1|root,33DPP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4546343_4	1128421.JAGA01000003_gene2874	5.725e-120	401.0	COG4531@1|root,COG4531@2|Bacteria,2NP5Y@2323|unclassified Bacteria	2|Bacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	actF	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4546343_8	204669.Acid345_3000	1.915e-63	226.0	COG2010@1|root,COG2010@2|Bacteria,3Y2MN@57723|Acidobacteria,2JI6T@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS2_k127_4546343_7	1128421.JAGA01000003_gene2872	2.373e-74	254.0	COG2010@1|root,COG2010@2|Bacteria,2NPSE@2323|unclassified Bacteria	2|Bacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
TLS2_k127_4546343_1	1128421.JAGA01000003_gene2871	4.479e-230	719.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	nrfD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
TLS2_k127_4546343_0	234267.Acid_0490	0.0	1136.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molydop_binding
TLS2_k127_4546343_5	204669.Acid345_3004	1.615e-92	308.0	COG3880@1|root,COG3880@2|Bacteria,3Y2KG@57723|Acidobacteria,2JHTD@204432|Acidobacteriia	204432|Acidobacteriia	S	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
TLS2_k127_4546343_11	204669.Acid345_4141	6.718e-30	126.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	ppdA	-	-	ko:K02650,ko:K02679,ko:K10926,ko:K12285	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl
TLS2_k127_4546343_9	1279009.ADICEAN_00589	1.406e-46	177.0	28IPG@1|root,2Z8PF@2|Bacteria,4NWTP@976|Bacteroidetes,47S9I@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4546343_10	204669.Acid345_0148	6.248e-40	162.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria,2JI38@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TLS2_k127_4583097_4	204669.Acid345_0196	9.689e-71	252.0	COG4733@1|root,COG4733@2|Bacteria,3Y53H@57723|Acidobacteria,2JJMD@204432|Acidobacteriia	204432|Acidobacteriia	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4583097_1	204669.Acid345_0177	3.079e-93	314.0	COG0179@1|root,COG0179@2|Bacteria,3Y30T@57723|Acidobacteria,2JJ0G@204432|Acidobacteriia	204432|Acidobacteriia	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
TLS2_k127_4583097_2	945713.IALB_0646	3.112e-89	308.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135	2.2.1.2,5.3.1.9	ko:K00616,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TLS2_k127_4583097_7	204669.Acid345_0179	1.365e-32	131.0	2EN0M@1|root,337VJ@2|Bacteria,3Y5R9@57723|Acidobacteria,2JNZF@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4583097_8	1487953.JMKF01000059_gene4922	9.311e-32	130.0	2BYVD@1|root,33GV2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4583097_3	204669.Acid345_0180	2.082e-82	282.0	COG0785@1|root,COG0785@2|Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein	ccdA	-	1.8.4.11,1.8.4.12	ko:K06196,ko:K12267	-	-	-	-	ko00000,ko01000,ko02000	5.A.1.2	-	-	AhpC-TSA,DsbD
TLS2_k127_4583097_5	204669.Acid345_0181	5.146e-40	161.0	COG0526@1|root,COG0526@2|Bacteria,3Y4K8@57723|Acidobacteria,2JJAP@204432|Acidobacteriia	204432|Acidobacteriia	CO	Glutathione peroxidase	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
TLS2_k127_4583097_6	204669.Acid345_0182	2.831e-37	149.0	COG4232@1|root,COG4232@2|Bacteria,3Y5QG@57723|Acidobacteria,2JK1Z@204432|Acidobacteriia	204432|Acidobacteriia	CO	Disulphide bond corrector protein DsbC	-	-	-	-	-	-	-	-	-	-	-	-	DsbC
TLS2_k127_4583097_0	204669.Acid345_0099	7.673e-109	356.0	COG0709@1|root,COG0709@2|Bacteria,3Y6V3@57723|Acidobacteria,2JM9D@204432|Acidobacteriia	204432|Acidobacteriia	E	AIR synthase related protein, C-terminal domain	-	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
TLS2_k127_4593436_1	661478.OP10G_0441	3.69e-89	309.0	COG4932@1|root,COG5276@1|root,COG4932@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,DUF3494,LVIVD
TLS2_k127_4593436_0	1382359.JIAL01000001_gene1038	1.896e-154	493.0	COG2896@1|root,COG2896@2|Bacteria,3Y30D@57723|Acidobacteria,2JIKJ@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_14,Mob_synth_C,Radical_SAM
TLS2_k127_4611441_1	1267535.KB906767_gene1107	3.576e-43	164.0	COG0629@1|root,COG0629@2|Bacteria,3Y4D2@57723|Acidobacteria,2JJ18@204432|Acidobacteriia	204432|Acidobacteriia	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_4611441_0	1340493.JNIF01000003_gene2100	8.297e-114	381.0	2EXCM@1|root,33QP8@2|Bacteria,3Y730@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4611441_2	1267535.KB906767_gene777	4.251e-32	131.0	COG2242@1|root,COG2242@2|Bacteria,3Y88R@57723|Acidobacteria	57723|Acidobacteria	H	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4615357_4	204669.Acid345_3825	8.71e-20	102.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	-	2.1.1.45,2.7.4.9	ko:K00560,ko:K00943	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02094,R02098,R02101	RC00002,RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
TLS2_k127_4615357_3	1185876.BN8_00552	1.363e-23	115.0	COG0438@1|root,COG0438@2|Bacteria,4NW2Q@976|Bacteroidetes,47VS6@768503|Cytophagia	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
TLS2_k127_4615357_1	204669.Acid345_3826	8.081e-97	331.0	COG0438@1|root,COG0438@2|Bacteria,3Y867@57723|Acidobacteria	57723|Acidobacteria	H	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_4615357_5	1123274.KB899425_gene2719	3.835e-08	65.0	COG0558@1|root,COG0558@2|Bacteria,2J8HW@203691|Spirochaetes	203691|Spirochaetes	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
TLS2_k127_4615357_2	589924.Ferp_2388	1.154e-32	138.0	COG0500@1|root,arCOG04347@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Methyltransf_11
TLS2_k127_462676_0	204669.Acid345_1714	5.368e-122	404.0	COG1207@1|root,COG1207@2|Bacteria,3Y3SI@57723|Acidobacteria,2JIVK@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
TLS2_k127_462676_1	204669.Acid345_2188	3.462e-121	406.0	COG0391@1|root,COG0391@2|Bacteria,3Y3ZE@57723|Acidobacteria,2JITK@204432|Acidobacteriia	204432|Acidobacteriia	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
TLS2_k127_462676_4	204669.Acid345_2189	3.55e-62	226.0	COG0457@1|root,COG0457@2|Bacteria,3Y4XQ@57723|Acidobacteria,2JJFK@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
TLS2_k127_462676_6	401053.AciPR4_1335	7.643e-44	167.0	2AAGQ@1|root,30ZTQ@2|Bacteria,3Y4IN@57723|Acidobacteria,2JJDR@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function with PCYCGC motif	-	-	-	-	-	-	-	-	-	-	-	-	PCYCGC
TLS2_k127_462676_3	204669.Acid345_2191	1.813e-68	237.0	COG0681@1|root,COG0681@2|Bacteria,3Y49Z@57723|Acidobacteria,2JJ4I@204432|Acidobacteriia	204432|Acidobacteriia	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
TLS2_k127_462676_7	234267.Acid_4721	1.853e-30	124.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
TLS2_k127_462676_8	1340493.JNIF01000003_gene4714	6.231e-28	128.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_462676_2	1297742.A176_01806	3.884e-117	387.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_462676_5	1382359.JIAL01000001_gene2523	9.433e-55	193.0	COG0505@1|root,COG0505@2|Bacteria,3Y31Y@57723|Acidobacteria,2JIB8@204432|Acidobacteriia	204432|Acidobacteriia	F	TIGRFAM Carbamoyl-phosphate synthase, small subunit	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
TLS2_k127_4634955_6	1120973.AQXL01000130_gene1193	8.165e-80	295.0	COG1404@1|root,COG1404@2|Bacteria,1UZRQ@1239|Firmicutes,4HEVW@91061|Bacilli	91061|Bacilli	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8,SLH
TLS2_k127_4634955_11	234267.Acid_2810	2.547e-20	98.0	COG2128@1|root,COG2128@2|Bacteria,3Y8IA@57723|Acidobacteria	57723|Acidobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_4634955_8	1121920.AUAU01000004_gene660	6.346e-56	200.0	COG0454@1|root,COG0456@2|Bacteria,3Y4T4@57723|Acidobacteria	57723|Acidobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_4634955_4	1267534.KB906754_gene3350	5.302e-106	362.0	COG0457@1|root,COG0457@2|Bacteria,3Y46H@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4634955_1	204669.Acid345_4629	3.379e-215	676.0	COG1206@1|root,COG1206@2|Bacteria,3Y2KD@57723|Acidobacteria,2JIGU@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
TLS2_k127_4634955_2	204669.Acid345_4633	3.146e-194	617.0	COG1160@1|root,COG1160@2|Bacteria,3Y3AC@57723|Acidobacteria,2JIAS@204432|Acidobacteriia	204432|Acidobacteriia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
TLS2_k127_4634955_0	1267534.KB906757_gene852	7.943e-259	813.0	COG1199@1|root,COG1199@2|Bacteria,3Y3DN@57723|Acidobacteria,2JHJZ@204432|Acidobacteriia	204432|Acidobacteriia	L	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
TLS2_k127_4634955_9	401053.AciPR4_3574	5.044e-53	191.0	COG0720@1|root,COG0720@2|Bacteria,3Y4HE@57723|Acidobacteria,2JJ9Q@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM 6-pyruvoyl tetrahydropterin	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
TLS2_k127_4634955_10	1340493.JNIF01000003_gene3076	5.635e-52	199.0	COG0457@1|root,COG0457@2|Bacteria,3Y3BD@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TPR_11,TPR_16,TPR_2,TPR_8
TLS2_k127_4634955_3	204669.Acid345_4646	4.774e-120	400.0	COG0303@1|root,COG0303@2|Bacteria,3Y3F0@57723|Acidobacteria,2JICE@204432|Acidobacteriia	204432|Acidobacteriia	H	TIGRFAM molybdenum cofactor synthesis	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS2_k127_4634955_7	204669.Acid345_4647	7.106e-59	208.0	COG0315@1|root,COG0315@2|Bacteria,3Y4IY@57723|Acidobacteria,2JJ7K@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
TLS2_k127_4634955_5	204669.Acid345_4648	2.06e-96	321.0	COG0745@1|root,COG0745@2|Bacteria,3Y8XM@57723|Acidobacteria	57723|Acidobacteria	T	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,Response_reg
TLS2_k127_4662676_1	204669.Acid345_1784	1.908e-12	81.0	COG0546@1|root,COG0546@2|Bacteria,3Y4RC@57723|Acidobacteria,2JJAE@204432|Acidobacteriia	204432|Acidobacteriia	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_4662676_0	1382359.JIAL01000001_gene1956	0.0	1124.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,3Y34Y@57723|Acidobacteria,2JHQ9@204432|Acidobacteriia	204432|Acidobacteriia	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
TLS2_k127_4670154_2	204669.Acid345_0099	7.886e-25	105.0	COG0709@1|root,COG0709@2|Bacteria,3Y6V3@57723|Acidobacteria,2JM9D@204432|Acidobacteriia	204432|Acidobacteriia	E	AIR synthase related protein, C-terminal domain	-	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
TLS2_k127_4670154_3	204669.Acid345_4477	8.371e-09	68.0	COG2823@1|root,COG2823@2|Bacteria	2|Bacteria	S	hyperosmotic response	osmY_1	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON,CBS
TLS2_k127_4670154_0	204669.Acid345_4476	7.739e-116	380.0	COG1230@1|root,COG1230@2|Bacteria,3Y32W@57723|Acidobacteria,2JIVH@204432|Acidobacteriia	204432|Acidobacteriia	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
TLS2_k127_4670154_1	204669.Acid345_4473	7.329e-32	129.0	COG3872@1|root,COG3872@2|Bacteria,3Y66K@57723|Acidobacteria,2JKRW@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1385)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
TLS2_k127_4680315_4	204669.Acid345_0232	1.356e-57	208.0	COG0673@1|root,COG0673@2|Bacteria,3Y3ET@57723|Acidobacteria,2JHRR@204432|Acidobacteriia	204432|Acidobacteriia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_4680315_7	270374.MELB17_13562	2.477e-26	110.0	COG3549@1|root,COG3549@2|Bacteria,1PU0J@1224|Proteobacteria,1SF9Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	RelE-like toxin of type II toxin-antitoxin system HigB	higB	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
TLS2_k127_4680315_8	270374.MELB17_13557	2.495e-24	105.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,1SCYV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	TIGRFAM Addiction module antidote protein, HigA	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
TLS2_k127_4680315_6	1279009.ADICEAN_02760	4.722e-41	161.0	COG2318@1|root,COG2318@2|Bacteria,4NRAP@976|Bacteroidetes,47NZT@768503|Cytophagia	976|Bacteroidetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_4680315_1	234267.Acid_4051	4.037e-156	504.0	COG0624@1|root,COG0624@2|Bacteria,3Y3F2@57723|Acidobacteria	2|Bacteria	E	TIGRFAM amidase, hydantoinase carbamoylase	amaB	-	3.5.1.116,3.5.1.6,3.5.1.87,3.5.3.9	ko:K02083,ko:K06016,ko:K18151	ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120	M00046	R00469,R00905,R02423,R04666	RC00064,RC00096,RC00153,RC02798,RC02805	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_4680315_2	204669.Acid345_4554	1.016e-115	381.0	COG3494@1|root,COG3494@2|Bacteria,3Y3KI@57723|Acidobacteria,2JIMV@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
TLS2_k127_4680315_5	1128421.JAGA01000002_gene1329	7.314e-44	171.0	COG0642@1|root,COG2203@1|root,COG3852@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3852@2|Bacteria,2NQNP@2323|unclassified Bacteria	2|Bacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF,HATPase_c,HisKA,HisKA_7TM,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_4680315_0	204669.Acid345_3982	7.4e-167	537.0	COG1228@1|root,COG1228@2|Bacteria,3Y47R@57723|Acidobacteria,2JP2Q@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_4680315_9	204669.Acid345_2599	5.347e-20	96.0	COG0239@1|root,COG0239@2|Bacteria,3Y54A@57723|Acidobacteria,2JJPV@204432|Acidobacteriia	204432|Acidobacteriia	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TLS2_k127_4680315_3	204669.Acid345_0695	4.513e-115	383.0	COG1232@1|root,COG1232@2|Bacteria,3Y2X5@57723|Acidobacteria,2JI03@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS2_k127_4709_1	1242864.D187_000364	0.0	1024.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YTUI@29|Myxococcales	28221|Deltaproteobacteria	P	copper-translocating P-type ATPase	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
TLS2_k127_4709_11	204669.Acid345_2215	5.606e-19	88.0	2E4YK@1|root,32ZSE@2|Bacteria,3Y5GF@57723|Acidobacteria,2JK1P@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4709_12	1300345.LF41_1439	1.002e-15	87.0	2E5BX@1|root,3303Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4709_4	420324.KI912071_gene8168	1.331e-91	310.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_4709_8	204669.Acid345_2737	3.533e-59	213.0	COG0127@1|root,COG0127@2|Bacteria,3Y4WS@57723|Acidobacteria,2JJJJ@204432|Acidobacteriia	204432|Acidobacteriia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
TLS2_k127_4709_9	204669.Acid345_2569	6.53e-49	184.0	298YX@1|root,2ZW2P@2|Bacteria	2|Bacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4709_6	204669.Acid345_2570	3.536e-75	261.0	COG2009@1|root,COG2009@2|Bacteria,3Y4C4@57723|Acidobacteria,2JJ65@204432|Acidobacteriia	204432|Acidobacteriia	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS2_k127_4709_0	204669.Acid345_2571	0.0	1030.0	COG1053@1|root,COG1053@2|Bacteria,3Y2MQ@57723|Acidobacteria,2JIC4@204432|Acidobacteriia	204432|Acidobacteriia	C	Succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_4709_3	204669.Acid345_2572	1.031e-125	405.0	COG0479@1|root,COG0479@2|Bacteria,3Y39I@57723|Acidobacteria,2JHZS@204432|Acidobacteriia	204432|Acidobacteriia	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_8
TLS2_k127_4709_2	1278073.MYSTI_07176	5.904e-150	486.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,42NXB@68525|delta/epsilon subdivisions,2WMBF@28221|Deltaproteobacteria,2YW82@29|Myxococcales	28221|Deltaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
TLS2_k127_4709_7	1382359.JIAL01000001_gene2336	1.663e-68	241.0	COG0652@1|root,COG0652@2|Bacteria,3Y30A@57723|Acidobacteria,2JJ02@204432|Acidobacteriia	204432|Acidobacteriia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
TLS2_k127_4709_5	1267533.KB906736_gene1099	2.041e-89	297.0	COG0652@1|root,COG0652@2|Bacteria,3Y4CX@57723|Acidobacteria,2JJ67@204432|Acidobacteriia	204432|Acidobacteriia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
TLS2_k127_4709_10	1449346.JQMO01000003_gene3285	1.057e-25	112.0	2E5G8@1|root,3307X@2|Bacteria,2INVV@201174|Actinobacteria	201174|Actinobacteria	S	Immunity protein 53	-	-	-	-	-	-	-	-	-	-	-	-	Imm53
TLS2_k127_4709_13	204669.Acid345_1951	7.062e-12	65.0	COG0039@1|root,COG0039@2|Bacteria,3Y2PG@57723|Acidobacteria,2JII1@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
TLS2_k127_4735301_12	1382359.JIAL01000001_gene2439	6.346e-56	200.0	COG0452@1|root,COG0452@2|Bacteria,3Y2QJ@57723|Acidobacteria,2JIK5@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TLS2_k127_4735301_9	1382359.JIAL01000001_gene2440	1.164e-81	278.0	COG1573@1|root,COG1573@2|Bacteria,3Y43G@57723|Acidobacteria,2JJ46@204432|Acidobacteriia	204432|Acidobacteriia	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_4735301_13	1267534.KB906756_gene712	1.447e-54	211.0	2A3BS@1|root,30RTX@2|Bacteria,3Y943@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4735301_0	1267534.KB906754_gene3025	2.508e-297	933.0	COG1198@1|root,COG1198@2|Bacteria,3Y2NY@57723|Acidobacteria,2JI1K@204432|Acidobacteriia	204432|Acidobacteriia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
TLS2_k127_4735301_7	204669.Acid345_1182	4.167e-94	319.0	COG1994@1|root,COG1994@2|Bacteria,3Y4IT@57723|Acidobacteria,2JMSE@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4735301_17	204669.Acid345_1185	5.685e-46	166.0	COG0776@1|root,COG0776@2|Bacteria,3Y4U4@57723|Acidobacteria,2JP27@204432|Acidobacteriia	204432|Acidobacteriia	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_4735301_5	1267534.KB906754_gene3023	5.499e-107	352.0	COG0717@1|root,COG0717@2|Bacteria,3Y42N@57723|Acidobacteria,2JIA0@204432|Acidobacteriia	204432|Acidobacteriia	F	dUTPase	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
TLS2_k127_4735301_18	204669.Acid345_1188	8.194e-45	168.0	COG1923@1|root,COG1923@2|Bacteria,3Y5JI@57723|Acidobacteria,2JNEQ@204432|Acidobacteriia	204432|Acidobacteriia	S	Hfq protein	-	-	-	-	-	-	-	-	-	-	-	-	Hfq
TLS2_k127_4735301_2	204669.Acid345_1189	2.247e-140	458.0	COG2812@1|root,COG2812@2|Bacteria,3Y3C1@57723|Acidobacteria,2JI0U@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
TLS2_k127_4735301_10	204669.Acid345_3227	3.141e-72	255.0	COG0125@1|root,COG0125@2|Bacteria,3Y562@57723|Acidobacteria,2JHJE@204432|Acidobacteriia	204432|Acidobacteriia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
TLS2_k127_4735301_25	1267535.KB906767_gene110	1.102e-10	65.0	2DF3Q@1|root,2ZQCR@2|Bacteria,3Y8YJ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4735301_16	1123508.JH636452_gene7003	1.838e-48	182.0	COG0251@1|root,COG0251@2|Bacteria,2J0VA@203682|Planctomycetes	203682|Planctomycetes	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS2_k127_4735301_24	65393.PCC7424_1534	2.171e-11	71.0	2AVTU@1|root,31MME@2|Bacteria,1G9HZ@1117|Cyanobacteria,3KI0Y@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4735301_8	204669.Acid345_2880	3.262e-84	286.0	COG2120@1|root,COG2120@2|Bacteria,3Y4KA@57723|Acidobacteria,2JJDA@204432|Acidobacteriia	204432|Acidobacteriia	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K22135	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_4735301_6	204669.Acid345_2878	5.78e-102	337.0	COG0164@1|root,COG0164@2|Bacteria,3Y49K@57723|Acidobacteria,2JJ4J@204432|Acidobacteriia	204432|Acidobacteriia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
TLS2_k127_4735301_14	204669.Acid345_2876	3.805e-50	181.0	COG0335@1|root,COG0335@2|Bacteria,3Y4P6@57723|Acidobacteria,2JJ9V@204432|Acidobacteriia	204432|Acidobacteriia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
TLS2_k127_4735301_4	204669.Acid345_2875	6.285e-111	365.0	COG0336@1|root,COG0336@2|Bacteria,3Y3CS@57723|Acidobacteria,2JHUJ@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
TLS2_k127_4735301_15	204669.Acid345_2874	1.5e-48	183.0	COG0806@1|root,COG0806@2|Bacteria,3Y51G@57723|Acidobacteria,2JJGA@204432|Acidobacteriia	204432|Acidobacteriia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
TLS2_k127_4735301_23	1267535.KB906767_gene3056	1.027e-20	94.0	COG1837@1|root,COG1837@2|Bacteria,3Y5N5@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the UPF0109 family	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
TLS2_k127_4735301_20	1382359.JIAL01000001_gene1644	1.775e-32	128.0	COG0228@1|root,COG0228@2|Bacteria,3Y56G@57723|Acidobacteria,2JJQF@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TLS2_k127_4735301_11	1382359.JIAL01000001_gene864	1.357e-58	211.0	COG1225@1|root,COG1225@2|Bacteria,3Y42Q@57723|Acidobacteria,2JHRZ@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_4735301_1	204669.Acid345_3035	9.836e-230	720.0	COG0541@1|root,COG0541@2|Bacteria,3Y3AU@57723|Acidobacteria,2JHSM@204432|Acidobacteriia	204432|Acidobacteriia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TLS2_k127_4735301_3	204669.Acid345_3902	8.05e-133	431.0	COG0123@1|root,COG0123@2|Bacteria,3Y46F@57723|Acidobacteria,2JMK7@204432|Acidobacteriia	204432|Acidobacteriia	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TLS2_k127_4735301_19	204669.Acid345_0975	1.391e-33	131.0	COG0789@1|root,COG0789@2|Bacteria,3Y4KX@57723|Acidobacteria,2JJA1@204432|Acidobacteriia	204432|Acidobacteriia	K	MerR HTH family regulatory protein	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
TLS2_k127_4810643_2	1382359.JIAL01000001_gene1061	7.941e-125	407.0	COG1297@1|root,COG1297@2|Bacteria,3Y40W@57723|Acidobacteria,2JI44@204432|Acidobacteriia	204432|Acidobacteriia	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
TLS2_k127_4810643_12	1267533.KB906741_gene443	9.573e-56	210.0	COG1040@1|root,COG1040@2|Bacteria,3Y4SY@57723|Acidobacteria,2JJM7@204432|Acidobacteriia	204432|Acidobacteriia	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
TLS2_k127_4810643_8	204669.Acid345_4201	7.098e-92	307.0	COG1403@1|root,COG1403@2|Bacteria,3Y3PW@57723|Acidobacteria,2JI65@204432|Acidobacteriia	204432|Acidobacteriia	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
TLS2_k127_4810643_7	204669.Acid345_4197	8.303e-97	326.0	28M4B@1|root,2ZAI9@2|Bacteria,3Y3NA@57723|Acidobacteria,2JI3J@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4810643_16	204669.Acid345_4183	7.736e-36	136.0	COG1278@1|root,COG1278@2|Bacteria,3Y5GC@57723|Acidobacteria,2JK23@204432|Acidobacteriia	204432|Acidobacteriia	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_4810643_6	234267.Acid_3576	3.503e-98	333.0	COG1600@1|root,COG1600@2|Bacteria,3Y3TQ@57723|Acidobacteria	57723|Acidobacteria	C	Domain of unknown function (DUF1730)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
TLS2_k127_4810643_15	204669.Acid345_4175	5.935e-37	145.0	COG2952@1|root,COG2952@2|Bacteria,3Y55F@57723|Acidobacteria,2JJNJ@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF507)	-	-	-	ko:K09804	-	-	-	-	ko00000	-	-	-	DUF507
TLS2_k127_4810643_0	204669.Acid345_3219	2.164e-283	884.0	COG0323@1|root,COG0323@2|Bacteria,3Y2T3@57723|Acidobacteria,2JI29@204432|Acidobacteriia	204432|Acidobacteriia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
TLS2_k127_4810643_5	204669.Acid345_3220	1.213e-106	353.0	2EB73@1|root,3357Q@2|Bacteria,3Y85B@57723|Acidobacteria,2JNCN@204432|Acidobacteriia	204432|Acidobacteriia	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS2_k127_4810643_10	204669.Acid345_3221	3.189e-85	294.0	COG0283@1|root,COG0283@2|Bacteria,3Y4MV@57723|Acidobacteria,2JJ7N@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
TLS2_k127_4810643_4	204669.Acid345_0731	4.203e-115	386.0	COG3511@1|root,COG3511@2|Bacteria,3Y7AQ@57723|Acidobacteria,2JM7S@204432|Acidobacteriia	2|Bacteria	M	Phosphoesterase family	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
TLS2_k127_4810643_9	204669.Acid345_1031	1.848e-89	312.0	COG3595@1|root,COG3595@2|Bacteria,3Y3K3@57723|Acidobacteria,2JHKF@204432|Acidobacteriia	204432|Acidobacteriia	C	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_4810643_13	204669.Acid345_1029	4.475e-48	183.0	2DMGW@1|root,32REM@2|Bacteria,3Y4XX@57723|Acidobacteria,2JJER@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-B_box
TLS2_k127_4810643_14	204669.Acid345_1028	6.373e-46	175.0	COG5662@1|root,COG5662@2|Bacteria,3Y4S0@57723|Acidobacteria,2JJBH@204432|Acidobacteriia	204432|Acidobacteriia	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_4810643_11	204669.Acid345_1027	4.948e-77	264.0	COG1595@1|root,COG1595@2|Bacteria,3Y4HK@57723|Acidobacteria,2JJAJ@204432|Acidobacteriia	204432|Acidobacteriia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4810643_1	1267533.KB906733_gene2833	3.166e-207	650.0	COG0448@1|root,COG0448@2|Bacteria,3Y35M@57723|Acidobacteria,2JIZF@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_4810643_17	1340493.JNIF01000003_gene2471	4.44e-19	93.0	2EE2F@1|root,337X5@2|Bacteria,3Y5GQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4829639_0	204669.Acid345_3233	2.068e-263	820.0	COG0606@1|root,COG0606@2|Bacteria,3Y3JA@57723|Acidobacteria,2JI3F@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
TLS2_k127_4833994_5	204669.Acid345_1945	6.76e-124	403.0	COG0583@1|root,COG0583@2|Bacteria,3Y4EH@57723|Acidobacteria,2JJ60@204432|Acidobacteriia	204432|Acidobacteriia	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_4833994_11	204669.Acid345_1944	2.982e-89	314.0	COG1945@1|root,COG1945@2|Bacteria,3Y3KR@57723|Acidobacteria,2JIBD@204432|Acidobacteriia	204432|Acidobacteriia	S	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC)	-	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
TLS2_k127_4833994_18	204669.Acid345_0148	1.393e-09	69.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria,2JI38@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TLS2_k127_4833994_2	204669.Acid345_3443	2.308e-214	679.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria,2JIRH@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_4833994_8	204669.Acid345_1046	1.265e-97	330.0	COG0061@1|root,COG0061@2|Bacteria,3Y3E6@57723|Acidobacteria,2JIH5@204432|Acidobacteriia	204432|Acidobacteriia	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
TLS2_k127_4833994_9	204669.Acid345_1045	5.804e-97	324.0	COG1189@1|root,COG1189@2|Bacteria,3Y3HM@57723|Acidobacteria,2JIEB@204432|Acidobacteriia	204432|Acidobacteriia	J	FtsJ-like methyltransferase	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
TLS2_k127_4833994_17	211114.JOEF01000002_gene4138	3.344e-13	72.0	COG0695@1|root,COG0695@2|Bacteria,2IR0P@201174|Actinobacteria,4E5DS@85010|Pseudonocardiales	201174|Actinobacteria	O	PFAM Glutaredoxin-like domain (DUF836)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF836
TLS2_k127_4833994_3	204669.Acid345_0667	3.663e-212	671.0	COG0318@1|root,COG0318@2|Bacteria,3Y65U@57723|Acidobacteria,2JN2C@204432|Acidobacteriia	204432|Acidobacteriia	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_4833994_12	472759.Nhal_1835	2.849e-67	244.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1S79G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport,GAF
TLS2_k127_4833994_14	1173025.GEI7407_3519	7.846e-53	199.0	COG1131@1|root,COG1131@2|Bacteria,1G1P6@1117|Cyanobacteria,1H7BN@1150|Oscillatoriales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4833994_19	765952.PUV_07070	7.173e-08	63.0	COG0842@1|root,COG0842@2|Bacteria,2JGI3@204428|Chlamydiae	204428|Chlamydiae	U	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_4833994_16	204669.Acid345_1103	4.116e-21	97.0	2E23W@1|root,32XB6@2|Bacteria,3Y5B9@57723|Acidobacteria,2JJRH@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_4833994_1	215803.DB30_7421	6.132e-252	796.0	COG1164@1|root,COG1164@2|Bacteria,1Q3C4@1224|Proteobacteria,4393F@68525|delta/epsilon subdivisions,2X49B@28221|Deltaproteobacteria,2YYJ7@29|Myxococcales	28221|Deltaproteobacteria	E	Oligoendopeptidase f	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4833994_6	204669.Acid345_2940	4.921e-117	396.0	COG2234@1|root,COG2234@2|Bacteria,3Y3SC@57723|Acidobacteria,2JIVJ@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_4833994_10	1340493.JNIF01000004_gene937	1.75e-90	312.0	COG4783@1|root,COG4783@2|Bacteria,3Y3GF@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase M48 Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS2_k127_4833994_15	1382359.JIAL01000001_gene1679	1.589e-42	159.0	COG0234@1|root,COG0234@2|Bacteria,3Y4VQ@57723|Acidobacteria,2JJEF@204432|Acidobacteriia	204432|Acidobacteriia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TLS2_k127_4833994_0	204669.Acid345_1097	4.947e-301	929.0	COG0459@1|root,COG0459@2|Bacteria,3Y37I@57723|Acidobacteria,2JIV1@204432|Acidobacteriia	204432|Acidobacteriia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS2_k127_4833994_4	378806.STAUR_1260	1.485e-159	525.0	COG3410@1|root,COG3410@2|Bacteria,1PRQ3@1224|Proteobacteria,42Y83@68525|delta/epsilon subdivisions,2WTIQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Uncharacterized conserved protein (DUF2075)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2075
TLS2_k127_4833994_13	290397.Adeh_3744	2.925e-60	217.0	COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,42RKY@68525|delta/epsilon subdivisions,2WNSM@28221|Deltaproteobacteria,2YXUH@29|Myxococcales	28221|Deltaproteobacteria	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_4833994_7	204669.Acid345_1074	2.458e-112	371.0	COG0111@1|root,COG0111@2|Bacteria,3Y3VD@57723|Acidobacteria,2JHVT@204432|Acidobacteriia	204432|Acidobacteriia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh_C
TLS2_k127_4868350_1	706587.Desti_0932	1.816e-148	490.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42MAP@68525|delta/epsilon subdivisions,2WIYI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Sodium sulphate symporter	sdcS	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
TLS2_k127_4868350_0	234267.Acid_0380	6.869e-151	490.0	COG1502@1|root,COG1502@2|Bacteria,3Y2GD@57723|Acidobacteria	57723|Acidobacteria	I	PLD-like domain	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
TLS2_k127_4868350_2	204669.Acid345_0496	3.594e-90	304.0	COG3568@1|root,COG3568@2|Bacteria,3Y4HM@57723|Acidobacteria,2JKST@204432|Acidobacteriia	204432|Acidobacteriia	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_4868350_3	1128421.JAGA01000001_gene2348	2.174e-78	274.0	COG1478@1|root,COG1478@2|Bacteria,2NQRM@2323|unclassified Bacteria	2|Bacteria	S	F420-0:Gamma-glutamyl ligase	fbiB	GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase,Nitroreductase
TLS2_k127_4868350_4	1121106.JQKB01000008_gene1358	7.483e-31	130.0	COG1920@1|root,COG1920@2|Bacteria,1RJPN@1224|Proteobacteria,2UAA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
TLS2_k127_4868350_5	765420.OSCT_1607	1.174e-16	83.0	COG0391@1|root,COG0391@2|Bacteria,2G5S2@200795|Chloroflexi,376XW@32061|Chloroflexia	32061|Chloroflexia	S	TIGRFAM LPPG domain	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
TLS2_k127_4876844_1	204669.Acid345_4714	4.136e-15	79.0	28JPX@1|root,2Z9FV@2|Bacteria,3Y48N@57723|Acidobacteria,2JHSH@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4876844_0	204669.Acid345_0353	3.225e-100	341.0	COG0491@1|root,COG0491@2|Bacteria,3Y54H@57723|Acidobacteria,2JM9F@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_4886599_10	234267.Acid_6939	2.279e-136	461.0	COG1629@1|root,COG4771@2|Bacteria,3Y2MF@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_4886599_8	204669.Acid345_0531	1.899e-159	515.0	COG5368@1|root,COG5368@2|Bacteria,3Y2MM@57723|Acidobacteria,2JI52@204432|Acidobacteriia	204432|Acidobacteriia	S	Putative glucoamylase	-	-	-	-	-	-	-	-	-	-	-	-	Glycoamylase
TLS2_k127_4886599_12	316274.Haur_4048	5.002e-106	355.0	COG0673@1|root,COG0673@2|Bacteria,2G6PI@200795|Chloroflexi,377TM@32061|Chloroflexia	32061|Chloroflexia	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4886599_5	1185876.BN8_04111	8.284e-195	623.0	COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,47KNU@768503|Cytophagia	976|Bacteroidetes	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
TLS2_k127_4886599_26	1051646.VITU9109_14061	5.149e-23	115.0	COG0265@1|root,COG3291@1|root,COG0265@2|Bacteria,COG3291@2|Bacteria,1R6VW@1224|Proteobacteria,1SNEA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4886599_9	326297.Sama_3313	7.559e-159	526.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,2Q8YZ@267890|Shewanellaceae	1236|Gammaproteobacteria	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	PA,PKD,Peptidase_S8
TLS2_k127_4886599_27	204669.Acid345_1592	2.689e-14	82.0	COG3063@1|root,COG3063@2|Bacteria,3Y5SX@57723|Acidobacteria	57723|Acidobacteria	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
TLS2_k127_4886599_25	204669.Acid345_2462	3.743e-34	136.0	COG0784@1|root,COG0784@2|Bacteria,3Y5K0@57723|Acidobacteria,2JJYE@204432|Acidobacteriia	204432|Acidobacteriia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_4886599_3	204669.Acid345_3840	8.168e-232	757.0	COG1470@1|root,COG1629@1|root,COG1470@2|Bacteria,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K13735,ko:K20276	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001	-	-	-	ASH,CarboxypepD_reg,DUF11,FlgD_ig,HYR,Laminin_G_3,Plug,TonB_dep_Rec
TLS2_k127_4886599_13	1382359.JIAL01000001_gene1871	2.54e-98	359.0	COG1629@1|root,COG4771@2|Bacteria,3Y3P9@57723|Acidobacteria,2JHUB@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_4886599_7	1128421.JAGA01000003_gene2861	1.583e-161	530.0	COG3387@1|root,COG3387@2|Bacteria,2NQPX@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
TLS2_k127_4886599_17	1382359.JIAL01000001_gene1146	1.966e-69	254.0	2DCQR@1|root,2ZEZD@2|Bacteria,3Y8W1@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
TLS2_k127_4886599_22	204669.Acid345_4315	1.91e-38	151.0	COG0251@1|root,COG0251@2|Bacteria,3Y57T@57723|Acidobacteria,2JJQ3@204432|Acidobacteriia	204432|Acidobacteriia	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS2_k127_4886599_23	639030.JHVA01000001_gene474	3.098e-38	144.0	COG0184@1|root,COG0184@2|Bacteria,3Y55T@57723|Acidobacteria,2JJMX@204432|Acidobacteriia	204432|Acidobacteriia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
TLS2_k127_4886599_0	204669.Acid345_1995	0.0	1090.0	COG1185@1|root,COG1185@2|Bacteria,3Y2UG@57723|Acidobacteria,2JI5F@204432|Acidobacteriia	204432|Acidobacteriia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TLS2_k127_4886599_19	264732.Moth_0371	6.569e-53	196.0	COG0730@1|root,COG0730@2|Bacteria,1TPMA@1239|Firmicutes,249II@186801|Clostridia,42FVW@68295|Thermoanaerobacterales	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_4886599_4	204669.Acid345_2108	6.323e-206	676.0	COG0766@1|root,COG0766@2|Bacteria,3Y2IC@57723|Acidobacteria,2JI7D@204432|Acidobacteriia	204432|Acidobacteriia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TLS2_k127_4886599_14	1267533.KB906739_gene2550	2.165e-94	321.0	COG2103@1|root,COG2103@2|Bacteria,3Y3K7@57723|Acidobacteria,2JHUS@204432|Acidobacteriia	204432|Acidobacteriia	G	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	-	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS,SIS_2
TLS2_k127_4886599_11	204669.Acid345_2616	3.71e-122	402.0	COG1680@1|root,COG1680@2|Bacteria,3Y3GQ@57723|Acidobacteria,2JII4@204432|Acidobacteriia	204432|Acidobacteriia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_4886599_2	204669.Acid345_2615	3.411e-289	908.0	COG1680@1|root,COG3876@1|root,COG1680@2|Bacteria,COG3876@2|Bacteria,3Y2UC@57723|Acidobacteria,2JIDD@204432|Acidobacteriia	204432|Acidobacteriia	V	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343,SSF
TLS2_k127_4886599_15	278963.ATWD01000001_gene1442	1.041e-88	302.0	COG2367@1|root,COG2367@2|Bacteria,3Y3UF@57723|Acidobacteria,2JIU8@204432|Acidobacteriia	204432|Acidobacteriia	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
TLS2_k127_4886599_18	204669.Acid345_2334	8.045e-64	227.0	COG2948@1|root,COG2948@2|Bacteria,3Y81Q@57723|Acidobacteria,2JN9S@204432|Acidobacteriia	204432|Acidobacteriia	U	multi-organism process	-	-	-	ko:K03195	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbI
TLS2_k127_4886599_20	204669.Acid345_2333	1.182e-51	194.0	COG2968@1|root,COG2968@2|Bacteria	2|Bacteria	S	cellular response to heat	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
TLS2_k127_4886599_6	204669.Acid345_2498	2.542e-183	580.0	COG3437@1|root,COG3437@2|Bacteria,3Y2TI@57723|Acidobacteria,2JHKC@204432|Acidobacteriia	204432|Acidobacteriia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,Response_reg
TLS2_k127_4886599_1	204669.Acid345_2497	3.046e-298	952.0	COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482,ko:K03557	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02022,ko03000,ko03036,ko03400	-	-	-	GAF,GAF_2,HATPase_c,HTH_8,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,RsbRD_N
TLS2_k127_4886599_21	204669.Acid345_2496	2.49e-49	181.0	COG1595@1|root,COG1595@2|Bacteria,3Y5P6@57723|Acidobacteria,2JK1E@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r4_2
TLS2_k127_4886599_16	1198114.AciX9_2148	1.269e-75	257.0	COG1207@1|root,COG1207@2|Bacteria,3Y3SI@57723|Acidobacteria,2JIVK@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
TLS2_k127_4910468_5	1382359.JIAL01000001_gene1783	5.647e-156	496.0	COG1063@1|root,COG1063@2|Bacteria,3Y3KU@57723|Acidobacteria,2JIQ4@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_4910468_1	234267.Acid_5783	5.49e-279	872.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_4910468_2	204669.Acid345_3919	3.014e-232	722.0	COG0156@1|root,COG0156@2|Bacteria,3Y3J2@57723|Acidobacteria,2JI0H@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_4910468_17	563192.HMPREF0179_01871	4.03e-23	104.0	2DBJQ@1|root,32TXM@2|Bacteria,1NYZU@1224|Proteobacteria,430QH@68525|delta/epsilon subdivisions,2WW08@28221|Deltaproteobacteria,2MCPA@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_excise
TLS2_k127_4910468_4	204669.Acid345_4149	9.09e-168	543.0	COG0044@1|root,COG0044@2|Bacteria,3Y34R@57723|Acidobacteria,2JIA3@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS2_k127_4910468_9	204669.Acid345_4569	1.356e-104	347.0	COG0540@1|root,COG0540@2|Bacteria,3Y3KK@57723|Acidobacteria,2JIUN@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_4910468_10	240015.ACP_2011	1.325e-81	278.0	COG2065@1|root,COG2065@2|Bacteria,3Y2S1@57723|Acidobacteria,2JHTI@204432|Acidobacteriia	204432|Acidobacteriia	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
TLS2_k127_4910468_18	204669.Acid345_4567	8.151e-16	86.0	2EJVM@1|root,33DKB@2|Bacteria,3Y5SU@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4910468_15	204669.Acid345_4565	9.528e-32	134.0	2C0SZ@1|root,32R7J@2|Bacteria,3Y4ZA@57723|Acidobacteria,2JJII@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4910468_6	204669.Acid345_4559	6.157e-131	425.0	COG0324@1|root,COG0324@2|Bacteria,3Y3CE@57723|Acidobacteria,2JICH@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
TLS2_k127_4910468_8	204669.Acid345_0235	1.129e-110	373.0	COG1043@1|root,COG1043@2|Bacteria,3Y33C@57723|Acidobacteria,2JI06@204432|Acidobacteriia	204432|Acidobacteriia	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
TLS2_k127_4910468_12	278963.ATWD01000001_gene3861	9.477e-62	234.0	COG0764@1|root,COG0764@2|Bacteria,3Y4CG@57723|Acidobacteria,2JJ97@204432|Acidobacteriia	204432|Acidobacteriia	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
TLS2_k127_4910468_7	204669.Acid345_0237	1.636e-120	408.0	COG0624@1|root,COG0624@2|Bacteria,3Y3J0@57723|Acidobacteria,2JI3Y@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase dimerisation domain	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_4910468_19	457570.Nther_1225	1.519e-13	71.0	COG1826@1|root,COG1826@2|Bacteria,1VFP2@1239|Firmicutes,24V8A@186801|Clostridia	186801|Clostridia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS2_k127_4910468_11	204669.Acid345_0240	7.593e-63	222.0	COG0424@1|root,COG0424@2|Bacteria,3Y4ZU@57723|Acidobacteria,2JJH8@204432|Acidobacteriia	204432|Acidobacteriia	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
TLS2_k127_4910468_3	204669.Acid345_0241	5.181e-219	703.0	COG0296@1|root,COG0296@2|Bacteria,3Y33J@57723|Acidobacteria,2JHJV@204432|Acidobacteriia	204432|Acidobacteriia	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	-	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
TLS2_k127_4910468_16	278963.ATWD01000001_gene1396	1.531e-28	121.0	2EETD@1|root,338KX@2|Bacteria,3Y5HI@57723|Acidobacteria,2JN5V@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4910468_14	1340493.JNIF01000003_gene2348	2.016e-33	138.0	COG3620@1|root,COG3620@2|Bacteria,3Y8HY@57723|Acidobacteria	57723|Acidobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS2_k127_4910468_0	1382359.JIAL01000001_gene807	0.0	1005.0	COG0481@1|root,COG0481@2|Bacteria,3Y3EX@57723|Acidobacteria,2JI4G@204432|Acidobacteriia	204432|Acidobacteriia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
TLS2_k127_4910468_13	204669.Acid345_0247	2.624e-35	147.0	COG2825@1|root,COG2825@2|Bacteria,3Y56P@57723|Acidobacteria,2JP1P@204432|Acidobacteriia	204432|Acidobacteriia	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
TLS2_k127_4910468_20	1227349.C170_21585	0.0009165	42.0	2E9KM@1|root,333TD@2|Bacteria,1VW4V@1239|Firmicutes,4HWQP@91061|Bacilli	91061|Bacilli	S	Immunity protein 26	-	-	-	-	-	-	-	-	-	-	-	-	Imm26
TLS2_k127_4973643_12	204669.Acid345_1326	1.509e-65	228.0	COG0648@1|root,COG0648@2|Bacteria,3Y35C@57723|Acidobacteria,2JI8X@204432|Acidobacteriia	204432|Acidobacteriia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
TLS2_k127_4973643_0	204669.Acid345_1328	0.0	1265.0	COG0495@1|root,COG0495@2|Bacteria,3Y37K@57723|Acidobacteria,2JIGF@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
TLS2_k127_4973643_1	204669.Acid345_1793	2.007e-259	806.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,3Y3VV@57723|Acidobacteria,2JHRV@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
TLS2_k127_4973643_18	1163407.UU7_03912	1.855e-23	108.0	2EJ52@1|root,33CW9@2|Bacteria,1PD05@1224|Proteobacteria,1SY6A@1236|Gammaproteobacteria,1X79D@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4973643_3	1267535.KB906767_gene2589	5.455e-188	608.0	COG0405@1|root,COG0405@2|Bacteria,3Y2I7@57723|Acidobacteria,2JKP3@204432|Acidobacteriia	204432|Acidobacteriia	M	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_4973643_15	1122223.KB890696_gene368	6.671e-37	142.0	COG4274@1|root,COG4274@2|Bacteria	2|Bacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
TLS2_k127_4973643_4	1382359.JIAL01000001_gene2834	1.858e-157	502.0	COG3684@1|root,COG3684@2|Bacteria,3Y33H@57723|Acidobacteria,2JIH2@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase	-	-	4.1.2.40	ko:K01635	ko00052,ko01100,ko02024,map00052,map01100,map02024	-	R01069	RC00438,RC00439	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS2_k127_4973643_11	661478.OP10G_2718	3.642e-94	317.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	AXE1,DLH
TLS2_k127_4973643_8	204669.Acid345_1616	2.737e-113	372.0	COG0689@1|root,COG0689@2|Bacteria,3Y2FP@57723|Acidobacteria,2JHM3@204432|Acidobacteriia	204432|Acidobacteriia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
TLS2_k127_4973643_14	204669.Acid345_2508	2.383e-37	150.0	COG5401@1|root,COG5401@2|Bacteria,3Y52P@57723|Acidobacteria,2JJF6@204432|Acidobacteriia	204432|Acidobacteriia	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
TLS2_k127_4973643_10	204669.Acid345_2507	1.315e-94	330.0	COG0860@1|root,COG0860@2|Bacteria,3Y4TT@57723|Acidobacteria,2JJID@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
TLS2_k127_4973643_5	1382359.JIAL01000001_gene1582	2.066e-134	443.0	COG4198@1|root,COG4198@2|Bacteria,3Y2H9@57723|Acidobacteria,2JIN5@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Uncharacterised conserved protein UCP033563	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
TLS2_k127_4973643_6	204669.Acid345_2506	4.177e-133	435.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria,2JI1J@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
TLS2_k127_4973643_9	204669.Acid345_2505	1.445e-105	354.0	COG2304@1|root,COG2304@2|Bacteria,3Y483@57723|Acidobacteria,2JI1N@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_4973643_7	240015.ACP_1007	1.533e-123	405.0	COG0031@1|root,COG0031@2|Bacteria,3Y39Y@57723|Acidobacteria,2JJ08@204432|Acidobacteriia	204432|Acidobacteriia	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_4973643_2	204669.Acid345_2499	2.713e-195	614.0	COG0626@1|root,COG0626@2|Bacteria,3Y2K5@57723|Acidobacteria,2JHVD@204432|Acidobacteriia	204432|Acidobacteriia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48,4.4.1.1,4.4.1.2,4.4.1.8	ko:K01739,ko:K01758,ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338,M00609	R00782,R00999,R01001,R01283,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00487,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02814,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
TLS2_k127_4973643_16	378806.STAUR_7979	8.135e-34	139.0	2E2RY@1|root,32XUA@2|Bacteria,1N9C1@1224|Proteobacteria,42XP0@68525|delta/epsilon subdivisions,2WT7T@28221|Deltaproteobacteria,2YVJE@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1579)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1579
TLS2_k127_4973643_19	469383.Cwoe_0217	8.179e-20	101.0	COG3832@1|root,COG3832@2|Bacteria,2HQ66@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_4973643_13	469383.Cwoe_0328	4.798e-50	186.0	COG0640@1|root,COG0640@2|Bacteria,2GJT9@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_4973643_17	404589.Anae109_1180	1.052e-26	112.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,42VE1@68525|delta/epsilon subdivisions,2WR7D@28221|Deltaproteobacteria,2Z0IS@29|Myxococcales	28221|Deltaproteobacteria	P	CutA1 divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
TLS2_k127_4973643_20	204669.Acid345_1751	5.593e-07	55.0	COG1109@1|root,COG1109@2|Bacteria,3Y2Y6@57723|Acidobacteria,2JHZU@204432|Acidobacteriia	204432|Acidobacteriia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_4989502_1	204669.Acid345_2204	4.41e-79	285.0	COG0705@1|root,COG0705@2|Bacteria,3Y5A9@57723|Acidobacteria,2JNBE@204432|Acidobacteriia	204432|Acidobacteriia	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS2_k127_4989502_0	204669.Acid345_2203	1.573e-106	355.0	COG0130@1|root,COG0130@2|Bacteria,3Y3PG@57723|Acidobacteria,2JIGA@204432|Acidobacteriia	204432|Acidobacteriia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
TLS2_k127_4989502_2	1282876.BAOK01000001_gene3434	3.459e-42	160.0	COG1917@1|root,COG1917@2|Bacteria,1RB86@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Cupin 2 conserved barrel domain protein	-	-	1.13.11.41	ko:K05913	ko00363,ko01120,map00363,map01120	-	R01305	RC00415,RC01565	ko00000,ko00001,ko01000	-	-	-	Cupin_7
TLS2_k127_4989502_3	1340493.JNIF01000004_gene259	2.928e-24	113.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_498997_2	1382359.JIAL01000001_gene2751	1.588e-44	169.0	COG0463@1|root,COG0463@2|Bacteria,3Y34G@57723|Acidobacteria,2JIGQ@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_498997_3	243231.GSU1945	1.556e-08	67.0	COG3209@1|root,COG3291@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,1Q4PP@1224|Proteobacteria,42YRG@68525|delta/epsilon subdivisions,2WUJR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3
TLS2_k127_498997_4	1089550.ATTH01000002_gene18	0.0001203	54.0	COG1470@1|root,COG4733@1|root,COG1470@2|Bacteria,COG4733@2|Bacteria,4PHV3@976|Bacteroidetes,1FK10@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_498997_1	163908.KB235896_gene1656	1.806e-102	338.0	COG0605@1|root,COG0605@2|Bacteria,1G0VH@1117|Cyanobacteria,1HK5Z@1161|Nostocales	1117|Cyanobacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
TLS2_k127_498997_0	204669.Acid345_1445	6.36e-171	562.0	COG1538@1|root,COG1538@2|Bacteria,3Y2NZ@57723|Acidobacteria,2JI75@204432|Acidobacteriia	204432|Acidobacteriia	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS2_k127_4993533_2	204669.Acid345_2976	1.384e-24	105.0	COG0704@1|root,COG0704@2|Bacteria	2|Bacteria	P	negative regulation of phosphate transmembrane transport	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TLS2_k127_4993533_1	401053.AciPR4_2690	6.051e-53	190.0	COG0394@1|root,COG0394@2|Bacteria	2|Bacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	arsC	-	1.20.4.1,2.8.4.2,3.1.3.48	ko:K01104,ko:K03325,ko:K03741,ko:K03892,ko:K18701	-	-	-	-	ko00000,ko01000,ko02000,ko03000	2.A.59	-	-	LMWPc
TLS2_k127_4993533_0	204669.Acid345_2975	1.399e-121	397.0	COG0226@1|root,COG0226@2|Bacteria,3Y399@57723|Acidobacteria,2JIVU@204432|Acidobacteriia	204432|Acidobacteriia	P	Belongs to the PstS family	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
TLS2_k127_5028431_2	1123242.JH636435_gene2291	1.908e-20	94.0	COG2327@1|root,COG2327@2|Bacteria	2|Bacteria	S	slime layer polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
TLS2_k127_5028431_0	1458275.AZ34_11410	9.965e-69	256.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,4ACW9@80864|Comamonadaceae	28216|Betaproteobacteria	I	AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS2_k127_5028431_1	1123388.AQWU01000021_gene1824	1.099e-30	132.0	COG1024@1|root,COG1024@2|Bacteria,1WIJM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS2_k127_504999_0	204669.Acid345_1337	4.69e-155	494.0	COG0492@1|root,COG0492@2|Bacteria,3Y2W6@57723|Acidobacteria,2JIIK@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_504999_1	886293.Sinac_3963	1.619e-154	516.0	COG2234@1|root,COG2234@2|Bacteria,2IWTP@203682|Planctomycetes	2|Bacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
TLS2_k127_504999_2	204669.Acid345_1338	1.637e-123	403.0	COG0506@1|root,COG0506@2|Bacteria,3Y2G8@57723|Acidobacteria,2JHRI@204432|Acidobacteriia	204432|Acidobacteriia	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
TLS2_k127_504999_3	204669.Acid345_1339	1.721e-91	311.0	COG2912@1|root,COG2912@2|Bacteria,3Y53Z@57723|Acidobacteria,2JMYF@204432|Acidobacteriia	204432|Acidobacteriia	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
TLS2_k127_504999_6	1267534.KB906754_gene2554	1.775e-19	98.0	2DZHS@1|root,32VB2@2|Bacteria,3Y54X@57723|Acidobacteria,2JJRJ@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF3106)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3106
TLS2_k127_504999_7	204669.Acid345_1341	1.989e-14	83.0	COG5660@1|root,COG5660@2|Bacteria,3Y556@57723|Acidobacteria,2JJU3@204432|Acidobacteriia	204432|Acidobacteriia	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_504999_4	1382359.JIAL01000001_gene194	1.383e-77	268.0	COG1595@1|root,COG1595@2|Bacteria,3Y2V2@57723|Acidobacteria,2JIXY@204432|Acidobacteriia	204432|Acidobacteriia	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_5069857_2	633149.Bresu_3131	9.634e-13	76.0	COG2234@1|root,COG2234@2|Bacteria,1RM41@1224|Proteobacteria,2UPKK@28211|Alphaproteobacteria,2KI98@204458|Caulobacterales	204458|Caulobacterales	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_5069857_1	1267534.KB906754_gene3242	6.644e-13	80.0	COG2706@1|root,COG2706@2|Bacteria,3Y76Q@57723|Acidobacteria,2JMA2@204432|Acidobacteriia	204432|Acidobacteriia	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS2_k127_5069857_0	269799.Gmet_1640	4.586e-122	402.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42Q5V@68525|delta/epsilon subdivisions,2WJA1@28221|Deltaproteobacteria,43TVR@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfk-1	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
TLS2_k127_5078288_1	204669.Acid345_1951	5.749e-170	537.0	COG0039@1|root,COG0039@2|Bacteria,3Y2PG@57723|Acidobacteria,2JII1@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
TLS2_k127_5078288_0	204669.Acid345_1950	9.036e-247	768.0	COG0538@1|root,COG0538@2|Bacteria,3Y2WW@57723|Acidobacteria,2JHTU@204432|Acidobacteriia	204432|Acidobacteriia	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_5078288_3	234267.Acid_0069	6.291e-133	459.0	COG1391@1|root,COG1391@2|Bacteria,3Y72J@57723|Acidobacteria	57723|Acidobacteria	H	Glutamate-ammonia ligase adenylyltransferase	-	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
TLS2_k127_5078288_2	368407.Memar_0908	1.76e-161	522.0	COG3263@1|root,arCOG01962@2157|Archaea,2Y0GT@28890|Euryarchaeota,2NB19@224756|Methanomicrobia	224756|Methanomicrobia	P	Sodium/hydrogen exchanger family	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger,TrkA_C
TLS2_k127_5078288_4	861299.J421_1312	1.909e-29	124.0	COG2318@1|root,COG2318@2|Bacteria,1ZV4R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_5121216_2	1123269.NX02_24565	3.396e-06	49.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TX5K@28211|Alphaproteobacteria,2K51N@204457|Sphingomonadales	204457|Sphingomonadales	T	Diguanylate cyclase, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3,Response_reg
TLS2_k127_5121216_0	204669.Acid345_4512	4.532e-131	425.0	COG4152@1|root,COG4152@2|Bacteria,3Y2NV@57723|Acidobacteria,2JHVX@204432|Acidobacteriia	204432|Acidobacteriia	S	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_5121216_1	278963.ATWD01000001_gene2021	6.32e-24	113.0	COG1668@1|root,COG1668@2|Bacteria,3Y2XV@57723|Acidobacteria,2JIQK@204432|Acidobacteriia	204432|Acidobacteriia	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_5144113_1	234267.Acid_0321	9.58e-42	154.0	COG4577@1|root,COG4577@2|Bacteria	2|Bacteria	CQ	ethanolamine catabolic process	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
TLS2_k127_5144113_3	234267.Acid_0322	1.731e-26	111.0	COG4576@1|root,COG4576@2|Bacteria	2|Bacteria	CQ	ethanolamine utilization protein EutN carboxysome structural protein Ccml	-	-	-	ko:K04028,ko:K08697	-	-	-	-	ko00000	-	-	-	EutN_CcmL
TLS2_k127_5144113_4	246194.CHY_0688	9.718e-17	83.0	COG4576@1|root,COG4576@2|Bacteria,1VEI4@1239|Firmicutes,24QJA@186801|Clostridia,42HKJ@68295|Thermoanaerobacterales	186801|Clostridia	CQ	Ethanolamine utilisation protein EutN/carboxysome	ccmL	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
TLS2_k127_5144113_2	234267.Acid_0324	5.569e-30	121.0	COG4576@1|root,COG4576@2|Bacteria	2|Bacteria	CQ	ethanolamine utilization protein EutN carboxysome structural protein Ccml	eutN	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
TLS2_k127_5144113_0	204669.Acid345_4483	1.885e-184	591.0	COG4206@1|root,COG4206@2|Bacteria,3Y42S@57723|Acidobacteria,2JHUU@204432|Acidobacteriia	204432|Acidobacteriia	H	TonB-dependent Receptor Plug Domain	-	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_5144447_31	1341151.ASZU01000015_gene2104	1.18e-14	81.0	COG0346@1|root,COG0346@2|Bacteria,1V6K2@1239|Firmicutes,4HJ55@91061|Bacilli,27CW5@186824|Thermoactinomycetaceae	91061|Bacilli	E	Glyoxalase-like domain	cadI	GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
TLS2_k127_5144447_30	204669.Acid345_2532	6.671e-27	113.0	COG0640@1|root,COG0640@2|Bacteria,3Y93C@57723|Acidobacteria,2JNRW@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_5144447_28	204669.Acid345_2531	5.104e-37	152.0	COG3147@1|root,COG3147@2|Bacteria,3Y98V@57723|Acidobacteria,2JP5C@204432|Acidobacteriia	204432|Acidobacteriia	S	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
TLS2_k127_5144447_17	1267533.KB906733_gene3469	6.241e-110	364.0	COG0330@1|root,COG0330@2|Bacteria,3Y33E@57723|Acidobacteria,2JHPX@204432|Acidobacteriia	204432|Acidobacteriia	O	SMART band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_5144447_14	204669.Acid345_2529	1.728e-130	433.0	COG1030@1|root,COG1030@2|Bacteria,3Y31N@57723|Acidobacteria,2JHS7@204432|Acidobacteriia	204432|Acidobacteriia	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
TLS2_k127_5144447_18	204669.Acid345_2528	1.45e-100	341.0	COG0457@1|root,COG3118@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria,3Y2VC@57723|Acidobacteria,2JHR2@204432|Acidobacteriia	204432|Acidobacteriia	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
TLS2_k127_5144447_12	204669.Acid345_2318	9.263e-140	491.0	COG1404@1|root,COG4409@1|root,COG1404@2|Bacteria,COG4409@2|Bacteria,3Y2GG@57723|Acidobacteria,2JI5J@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	ASH,DUF1573
TLS2_k127_5144447_23	682795.AciX8_3970	4.537e-58	216.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,3Y2H6@57723|Acidobacteria,2JIGC@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,Response_reg
TLS2_k127_5144447_4	1183438.GKIL_2224	2.31e-247	777.0	COG1164@1|root,COG1164@2|Bacteria	2|Bacteria	E	metalloendopeptidase activity	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2,Peptidase_M3
TLS2_k127_5144447_15	1198114.AciX9_2754	1.14e-122	400.0	COG0583@1|root,COG0583@2|Bacteria,3Y31P@57723|Acidobacteria,2JIC0@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_5144447_9	1382359.JIAL01000001_gene641	1.988e-153	502.0	COG0119@1|root,COG0119@2|Bacteria,3Y2WT@57723|Acidobacteria,2JI0S@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS2_k127_5144447_13	1267533.KB906733_gene3345	2.57e-134	449.0	COG0473@1|root,COG0473@2|Bacteria,3Y38Z@57723|Acidobacteria,2JHJJ@204432|Acidobacteriia	204432|Acidobacteriia	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_5144447_5	1303518.CCALI_02739	2.03e-226	719.0	COG0065@1|root,COG0065@2|Bacteria	2|Bacteria	E	3-isopropylmalate dehydratase activity	leuC	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531,iSB619.SA_RS10700	Aconitase
TLS2_k127_5144447_19	1303518.CCALI_02738	2.321e-81	278.0	COG0066@1|root,COG0066@2|Bacteria	2|Bacteria	E	3-isopropylmalate dehydratase activity	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
TLS2_k127_5144447_24	197221.22294938	2.104e-55	205.0	COG0229@1|root,COG0229@2|Bacteria,1G5S6@1117|Cyanobacteria	1117|Cyanobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
TLS2_k127_5144447_33	1347086.CCBA010000012_gene2030	4.639e-06	51.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5144447_16	1267534.KB906754_gene3142	2.177e-111	371.0	COG1363@1|root,COG1363@2|Bacteria,3Y2Y3@57723|Acidobacteria,2JKCI@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
TLS2_k127_5144447_7	1356852.N008_09330	1.201e-202	642.0	COG0612@1|root,COG0612@2|Bacteria,4NE0K@976|Bacteroidetes,47TKT@768503|Cytophagia	976|Bacteroidetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_5144447_10	861299.J421_0763	6.513e-150	488.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_5144447_11	204669.Acid345_1965	2.792e-144	471.0	2EX4M@1|root,33QFM@2|Bacteria,3Y6X0@57723|Acidobacteria,2JM6I@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5144447_2	204669.Acid345_1967	3.905e-253	812.0	COG0043@1|root,COG0043@2|Bacteria,3Y3BY@57723|Acidobacteria,2JHTW@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the UbiD family	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
TLS2_k127_5144447_8	518766.Rmar_1466	9.714e-158	509.0	COG1304@1|root,COG1304@2|Bacteria,4NEBK@976|Bacteroidetes	976|Bacteroidetes	C	Dehydrogenase	lldD	-	1.1.2.3,1.13.12.4	ko:K00101,ko:K00467	ko00620,ko01100,map00620,map01100	-	R00196,R00319	RC00044,RC01312	ko00000,ko00001,ko01000	-	-	-	FMN_dh
TLS2_k127_5144447_22	204669.Acid345_1715	4.145e-60	222.0	2C730@1|root,31C19@2|Bacteria,3Y52Y@57723|Acidobacteria,2JJFD@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5144447_25	204669.Acid345_1716	1.198e-51	190.0	COG1664@1|root,COG1664@2|Bacteria,3Y49V@57723|Acidobacteria,2JJ4E@204432|Acidobacteriia	57723|Acidobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS2_k127_5144447_21	204669.Acid345_1717	3.153e-70	245.0	COG0500@1|root,COG0500@2|Bacteria,3Y4Q0@57723|Acidobacteria,2JJCW@204432|Acidobacteriia	204432|Acidobacteriia	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS2_k127_5144447_20	204669.Acid345_1512	5.249e-81	284.0	COG0644@1|root,COG0644@2|Bacteria,3Y5HW@57723|Acidobacteria,2JK2B@204432|Acidobacteriia	204432|Acidobacteriia	C	Glucose inhibited division protein A	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5144447_27	1267533.KB906736_gene1269	7.461e-39	158.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
TLS2_k127_5144447_1	204669.Acid345_1514	4.649e-255	798.0	COG1132@1|root,COG1132@2|Bacteria,3Y32T@57723|Acidobacteria,2JIBZ@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter, transmembrane	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
TLS2_k127_5144447_0	204669.Acid345_1515	4.616e-272	859.0	COG0795@1|root,COG0795@2|Bacteria,3Y2F9@57723|Acidobacteria,2JI5V@204432|Acidobacteriia	204432|Acidobacteriia	S	Permease, YjgP YjgQ	-	-	-	-	-	-	-	-	-	-	-	-	YjgP_YjgQ
TLS2_k127_5144447_29	639030.JHVA01000001_gene249	1.737e-30	129.0	2A87I@1|root,30X8J@2|Bacteria,3Y4II@57723|Acidobacteria,2JJBN@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TrbI
TLS2_k127_5144447_32	1121121.KB894308_gene199	5.269e-12	70.0	COG1225@1|root,COG1225@2|Bacteria,1VP1K@1239|Firmicutes,4HRU3@91061|Bacilli,272P5@186822|Paenibacillaceae	91061|Bacilli	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_5144447_35	47763.JNZA01000034_gene2320	0.0006817	46.0	COG1225@1|root,COG1225@2|Bacteria,2H4Y3@201174|Actinobacteria	201174|Actinobacteria	O	Alkyl hydroperoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_5144447_6	204669.Acid345_1070	2.132e-213	674.0	COG0148@1|root,COG0148@2|Bacteria,3Y2IT@57723|Acidobacteria,2JI6Q@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TLS2_k127_5144447_3	204669.Acid345_1073	1.799e-250	782.0	COG0696@1|root,COG0696@2|Bacteria,3Y2YH@57723|Acidobacteria,2JIZ0@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
TLS2_k127_5144447_34	204669.Acid345_1074	3.364e-05	46.0	COG0111@1|root,COG0111@2|Bacteria,3Y3VD@57723|Acidobacteria,2JHVT@204432|Acidobacteriia	204432|Acidobacteriia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh_C
TLS2_k127_5163086_3	572477.Alvin_1965	9.317e-101	339.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1WWNR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2,5.1.3.5	ko:K01784,ko:K12448	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01473,R02984	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS2_k127_5163086_1	204669.Acid345_0770	9.019e-238	756.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_16,TPR_2,TPR_8
TLS2_k127_5163086_2	323261.Noc_0987	7.713e-179	593.0	COG3857@1|root,COG3857@2|Bacteria,1QUQD@1224|Proteobacteria,1T20Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
TLS2_k127_5163086_0	472759.Nhal_2969	5.36e-271	876.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1WWH2@135613|Chromatiales	135613|Chromatiales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS2_k127_5163086_6	204669.Acid345_3996	2.138e-26	115.0	2CDNF@1|root,2ZTQP@2|Bacteria,3Y955@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5163086_5	204669.Acid345_3995	9.947e-51	189.0	COG0558@1|root,COG0558@2|Bacteria,3Y4S5@57723|Acidobacteria,2JJ9R@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_5163086_4	204669.Acid345_3992	8.342e-54	192.0	COG0215@1|root,COG0215@2|Bacteria,3Y2PW@57723|Acidobacteria,2JHIQ@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
TLS2_k127_520716_18	204669.Acid345_3068	4.59e-26	116.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4A2@57723|Acidobacteria,2JJ6J@204432|Acidobacteriia	204432|Acidobacteriia	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
TLS2_k127_520716_9	240015.ACP_2871	4.243e-83	278.0	COG0503@1|root,COG0503@2|Bacteria,3Y30R@57723|Acidobacteria,2JHP2@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
TLS2_k127_520716_20	1382359.JIAL01000001_gene1998	1.869e-19	96.0	COG1254@1|root,COG1254@2|Bacteria,3Y55N@57723|Acidobacteria,2JJSV@204432|Acidobacteriia	204432|Acidobacteriia	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
TLS2_k127_520716_7	1382359.JIAL01000001_gene1200	3.017e-94	315.0	COG0231@1|root,COG0231@2|Bacteria,3Y373@57723|Acidobacteria,2JIEA@204432|Acidobacteriia	204432|Acidobacteriia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	-	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TLS2_k127_520716_17	350688.Clos_2010	3.365e-32	137.0	COG2905@1|root,COG2905@2|Bacteria,1VW3X@1239|Firmicutes,24MYP@186801|Clostridia,36IUV@31979|Clostridiaceae	186801|Clostridia	T	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_520716_13	204669.Acid345_0024	1.46e-45	168.0	COG1576@1|root,COG1576@2|Bacteria,3Y54B@57723|Acidobacteria,2JJN1@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
TLS2_k127_520716_4	682795.AciX8_1037	1.223e-156	507.0	COG1109@1|root,COG1109@2|Bacteria,3Y36F@57723|Acidobacteria,2JHU9@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_520716_14	204669.Acid345_2268	5.426e-43	165.0	COG5395@1|root,COG5395@2|Bacteria,3Y9FU@57723|Acidobacteria,2JP81@204432|Acidobacteriia	204432|Acidobacteriia	S	Predicted membrane protein (DUF2306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2306
TLS2_k127_520716_16	240015.ACP_0992	3.455e-37	148.0	COG0457@1|root,COG0457@2|Bacteria	240015.ACP_0992|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_520716_10	1121022.ABENE_20090	1.636e-73	271.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2U5VQ@28211|Alphaproteobacteria,2KH46@204458|Caulobacterales	204458|Caulobacterales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
TLS2_k127_520716_0	240015.ACP_1738	0.0	1073.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,3Y3X3@57723|Acidobacteria,2JHXN@204432|Acidobacteriia	204432|Acidobacteriia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
TLS2_k127_520716_21	1123322.KB904636_gene2789	1.3e-14	86.0	COG2706@1|root,COG3291@1|root,COG2706@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	wcoG	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF5122,Dabb,Lactonase,Laminin_G_3,PKD
TLS2_k127_520716_1	204669.Acid345_4134	1.39e-228	717.0	COG2204@1|root,COG2204@2|Bacteria,3Y41F@57723|Acidobacteria,2JIZR@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_520716_12	1337936.IJ00_04875	1.133e-50	201.0	COG0515@1|root,COG0642@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1GJ58@1117|Cyanobacteria,1HQI4@1161|Nostocales	2|Bacteria	T	Serine Threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GGDEF,Guanylate_cyc,HATPase_c,HisKA,HisKA_3,PAS_3,PAS_9,Pkinase,Response_reg
TLS2_k127_520716_19	338963.Pcar_2017	1.417e-22	113.0	COG0745@1|root,COG0745@2|Bacteria,1NWVW@1224|Proteobacteria,4304G@68525|delta/epsilon subdivisions,2WVAS@28221|Deltaproteobacteria,43UYY@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_520716_6	204669.Acid345_4132	5.117e-103	344.0	2CK1D@1|root,2ZAG7@2|Bacteria,3Y2W9@57723|Acidobacteria,2JHKD@204432|Acidobacteriia	204432|Acidobacteriia	S	Gas vesicle	-	-	-	-	-	-	-	-	-	-	-	-	GvpL_GvpF
TLS2_k127_520716_5	204669.Acid345_4131	1.385e-152	491.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,3Y6D3@57723|Acidobacteria,2JKGW@204432|Acidobacteriia	204432|Acidobacteriia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
TLS2_k127_520716_3	204669.Acid345_4110	5.323e-208	659.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,3Y2Y4@57723|Acidobacteria,2JI8D@204432|Acidobacteriia	204432|Acidobacteriia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroD	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
TLS2_k127_520716_11	204669.Acid345_4113	2.138e-69	241.0	COG0558@1|root,COG0558@2|Bacteria,3Y3CA@57723|Acidobacteria,2JI9A@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_520716_2	1267533.KB906735_gene5046	3.942e-226	706.0	COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria,2JI4Q@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS2_k127_520716_24	113395.AXAI01000006_gene1824	5.633e-07	57.0	COG3576@1|root,COG3576@2|Bacteria,1P363@1224|Proteobacteria	1224|Proteobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_5239350_0	204669.Acid345_4392	4.918e-309	972.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y333@57723|Acidobacteria	57723|Acidobacteria	KLTU	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
TLS2_k127_5239350_3	204669.Acid345_1894	6.731e-25	111.0	COG1278@1|root,COG1278@2|Bacteria,3Y57X@57723|Acidobacteria,2JP2M@204432|Acidobacteriia	204432|Acidobacteriia	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_5239350_2	448385.sce2804	2.029e-74	266.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TLS2_k127_5239350_1	1254432.SCE1572_17235	1.302e-308	967.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TLS2_k127_5289046_3	204669.Acid345_1194	3.101e-107	349.0	COG0752@1|root,COG0752@2|Bacteria,3Y3QC@57723|Acidobacteria,2JI3H@204432|Acidobacteriia	204432|Acidobacteriia	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
TLS2_k127_5289046_2	204669.Acid345_1193	2.547e-112	367.0	COG1381@1|root,COG1381@2|Bacteria,3Y4AX@57723|Acidobacteria,2JJ0T@204432|Acidobacteriia	204432|Acidobacteriia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
TLS2_k127_5289046_5	234267.Acid_1042	1.08e-49	177.0	COG1146@1|root,COG1146@2|Bacteria,3Y59N@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4
TLS2_k127_5289046_1	1121920.AUAU01000023_gene2395	6.412e-240	758.0	COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria	2|Bacteria	E	3-isopropylmalate dehydratase activity	leuD	-	4.2.1.3,4.2.1.33,4.2.1.35	ko:K01681,ko:K01703,ko:K01704,ko:K17749	ko00020,ko00290,ko00400,ko00630,ko00660,ko00720,ko00966,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00400,map00630,map00660,map00720,map00966,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00432,M00535,M00740	R01324,R01325,R01900,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170,R10501	RC00497,RC00498,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS2_k127_5289046_0	204669.Acid345_3229	3.381e-257	795.0	COG1158@1|root,COG1158@2|Bacteria,3Y2V3@57723|Acidobacteria,2JHRC@204432|Acidobacteriia	204432|Acidobacteriia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
TLS2_k127_5289046_4	204669.Acid345_1776	1.591e-94	337.0	COG2203@1|root,COG3829@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,RsbRD_N
TLS2_k127_5289046_6	1122137.AQXF01000003_gene2417	8.654e-48	182.0	COG2234@1|root,COG2234@2|Bacteria,1NVWC@1224|Proteobacteria	1224|Proteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_5321288_13	1260251.SPISAL_04840	1.151e-10	65.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1X01A@135613|Chromatiales	135613|Chromatiales	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_5321288_12	204669.Acid345_3988	4.671e-16	80.0	2E328@1|root,32Y2G@2|Bacteria,3Y5U5@57723|Acidobacteria,2JK3Y@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5321288_9	1121948.AUAC01000002_gene1626	2.761e-27	122.0	COG4783@1|root,COG4783@2|Bacteria	2|Bacteria	L	chaperone-mediated protein folding	-	-	-	ko:K11935	ko02026,map02026	-	-	-	ko00000,ko00001	-	-	-	DUF560,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
TLS2_k127_5321288_2	1278073.MYSTI_02808	1.364e-120	397.0	COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria	1224|Proteobacteria	S	major pilin protein fima	MA20_16755	-	-	-	-	-	-	-	-	-	-	-	DUF1028
TLS2_k127_5321288_14	383381.EH30_07505	1.271e-09	66.0	2EP6T@1|root,33GTJ@2|Bacteria,1NIHR@1224|Proteobacteria,2UJX6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4019
TLS2_k127_5321288_0	204669.Acid345_2632	6.917e-148	481.0	COG0477@1|root,COG2814@2|Bacteria,3Y3ZZ@57723|Acidobacteria,2JKTQ@204432|Acidobacteriia	204432|Acidobacteriia	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_5321288_3	204669.Acid345_2631	4.986e-118	387.0	COG0196@1|root,COG0196@2|Bacteria,3Y34N@57723|Acidobacteria,2JIGD@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the ribF family	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
TLS2_k127_5321288_4	204669.Acid345_2630	4.388e-113	370.0	COG1235@1|root,COG1235@2|Bacteria,3Y40S@57723|Acidobacteria,2JIH7@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
TLS2_k127_5321288_10	1267534.KB906759_gene2009	3.473e-26	122.0	29CGV@1|root,2ZZF9@2|Bacteria,3Y4JX@57723|Acidobacteria,2JJ9Y@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
TLS2_k127_5321288_5	204669.Acid345_2628	2.337e-105	355.0	COG0404@1|root,COG0404@2|Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	1.5.99.5,2.1.2.10	ko:K00605,ko:K06980,ko:K22086	ko00260,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200	M00532	R00609,R01221,R02300,R04125	RC00022,RC00069,RC00183,RC00190,RC00557,RC02834	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	GCV_T,GCV_T_C
TLS2_k127_5321288_1	1254432.SCE1572_47425	7.66e-130	424.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2YZ2Q@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_5321288_6	204669.Acid345_2627	9.152e-98	336.0	COG2856@1|root,COG2856@2|Bacteria,3Y3ZJ@57723|Acidobacteria,2JIJ0@204432|Acidobacteriia	204432|Acidobacteriia	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5321288_11	1173028.ANKO01000078_gene3871	8.455e-26	122.0	COG0500@1|root,COG2226@2|Bacteria,1G0W5@1117|Cyanobacteria,1H8EK@1150|Oscillatoriales	1117|Cyanobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
TLS2_k127_5321288_8	1041139.KB902646_gene3375	2.264e-42	159.0	2EBN3@1|root,335NA@2|Bacteria,1PS1W@1224|Proteobacteria,2V490@28211|Alphaproteobacteria,4BFSU@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_5321288_7	639030.JHVA01000001_gene3459	8.515e-78	263.0	COG0005@1|root,COG0005@2|Bacteria,3Y2MA@57723|Acidobacteria,2JI5Q@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_5363336_12	1267534.KB906759_gene1849	1.705e-40	159.0	COG1729@1|root,COG1729@2|Bacteria,3Y4ME@57723|Acidobacteria,2JJA9@204432|Acidobacteriia	204432|Acidobacteriia	S	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
TLS2_k127_5363336_6	3218.PP1S46_300V6.1	1.236e-96	329.0	COG0667@1|root,2S0PI@2759|Eukaryota,37UGN@33090|Viridiplantae,3GP0T@35493|Streptophyta	35493|Streptophyta	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_5363336_13	204669.Acid345_1569	3.212e-34	140.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria,2JP4Y@204432|Acidobacteriia	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
TLS2_k127_5363336_9	204669.Acid345_4143	3.584e-58	208.0	COG1399@1|root,COG1399@2|Bacteria,3Y4KJ@57723|Acidobacteria,2JJ8Y@204432|Acidobacteriia	204432|Acidobacteriia	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
TLS2_k127_5363336_15	204669.Acid345_4144	2.381e-29	117.0	COG0333@1|root,COG0333@2|Bacteria,3Y5HY@57723|Acidobacteria,2JJZ9@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal L32p protein family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
TLS2_k127_5363336_3	204669.Acid345_4145	2.679e-135	438.0	COG0416@1|root,COG0416@2|Bacteria,3Y3MM@57723|Acidobacteria,2JHTJ@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
TLS2_k127_5363336_4	204669.Acid345_4573	8.372e-129	420.0	COG0331@1|root,COG0331@2|Bacteria,3Y2TE@57723|Acidobacteria,2JI6J@204432|Acidobacteriia	204432|Acidobacteriia	I	malonyl CoA-acyl carrier protein transacylase	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
TLS2_k127_5363336_14	204669.Acid345_4574	4.73e-33	140.0	2B50C@1|root,31XTG@2|Bacteria,3Y4VH@57723|Acidobacteria,2JJMH@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5363336_0	204669.Acid345_4592	1.024e-176	571.0	COG1181@1|root,COG1181@2|Bacteria,3Y3HW@57723|Acidobacteria,2JI4N@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TLS2_k127_5363336_7	526227.Mesil_1816	4.862e-79	279.0	COG1404@1|root,COG1404@2|Bacteria,1WIDU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	3.4.21.111	ko:K20754	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Inhibitor_I9,Peptidase_S8
TLS2_k127_5363336_11	745411.B3C1_07691	1.099e-43	168.0	COG1917@1|root,COG1917@2|Bacteria,1MZF9@1224|Proteobacteria,1T0GF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1
TLS2_k127_5363336_1	671143.DAMO_1541	1.975e-160	516.0	COG1215@1|root,COG1215@2|Bacteria,2NNSB@2323|unclassified Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gpgS	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
TLS2_k127_5363336_2	671143.DAMO_1539	1.748e-158	512.0	COG0463@1|root,COG0463@2|Bacteria,2NQD9@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase family 2	-	-	2.4.1.268	ko:K21349	-	-	-	-	ko00000,ko01000	-	GT81	-	Glycos_transf_2
TLS2_k127_5363336_16	671143.DAMO_1538	1.584e-22	106.0	COG0668@1|root,COG0668@2|Bacteria,2NQ6B@2323|unclassified Bacteria	2|Bacteria	M	transmembrane transport	cmpX	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
TLS2_k127_5363336_8	671143.DAMO_1540	3.608e-77	277.0	COG3769@1|root,COG3769@2|Bacteria,2NR7G@2323|unclassified Bacteria	2|Bacteria	S	haloacid dehalogenase-like hydrolase	mpgP	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897	2.4.1.217,3.1.3.70	ko:K05947,ko:K07026	ko00051,map00051	-	R05768,R05790	RC00005,RC00017,RC00397,RC02748	ko00000,ko00001,ko01000,ko01003	-	-	-	Hydrolase_3
TLS2_k127_5363336_5	1142394.PSMK_05030	7.047e-104	351.0	COG0388@1|root,COG0388@2|Bacteria,2IXDC@203682|Planctomycetes	203682|Planctomycetes	K	COG0454 Histone acetyltransferase HPA2 and related	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
TLS2_k127_5363336_10	1142394.PSMK_05040	1.266e-49	186.0	COG0388@1|root,COG0388@2|Bacteria,2IXDC@203682|Planctomycetes	203682|Planctomycetes	K	COG0454 Histone acetyltransferase HPA2 and related	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_5411812_1	1121456.ATVA01000014_gene650	5.393e-48	176.0	COG3542@1|root,COG3542@2|Bacteria,1RHBE@1224|Proteobacteria,42T2P@68525|delta/epsilon subdivisions,2WPQ3@28221|Deltaproteobacteria,2MBSS@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Cupin superfamily (DUF985)	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
TLS2_k127_5411812_0	208439.AJAP_32485	9.982e-75	261.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4E1YY@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_5460023_6	504472.Slin_5224	7.656e-07	60.0	2A3W2@1|root,30SE9@2|Bacteria	2|Bacteria	L	PD-(D/E)XK endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_5
TLS2_k127_5460023_1	204669.Acid345_1452	6.497e-48	185.0	2DTV5@1|root,33MT0@2|Bacteria,3Y5UW@57723|Acidobacteria,2JNBS@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5460023_2	1121935.AQXX01000127_gene1130	3.087e-34	135.0	COG4319@1|root,COG4319@2|Bacteria,1N8AM@1224|Proteobacteria	1224|Proteobacteria	S	ketosteroid isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_5460023_5	926566.Terro_2880	4.493e-14	79.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,3Y8DM@57723|Acidobacteria	57723|Acidobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5460023_3	204669.Acid345_3901	1.401e-23	111.0	2CIPV@1|root,2ZADD@2|Bacteria,3Y3BA@57723|Acidobacteria,2JIUI@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5460023_0	204669.Acid345_0303	3.523e-53	193.0	COG1764@1|root,COG1764@2|Bacteria,3Y4TU@57723|Acidobacteria,2JJIC@204432|Acidobacteriia	204432|Acidobacteriia	O	peroxiredoxin, OsmC subfamily	-	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
TLS2_k127_5460023_4	204669.Acid345_0306	8.908e-19	92.0	2EBY8@1|root,335XJ@2|Bacteria,3Y5JK@57723|Acidobacteria,2JJW2@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5475667_1	204669.Acid345_4549	4.116e-122	396.0	COG1197@1|root,COG1197@2|Bacteria,3Y3IE@57723|Acidobacteria,2JIHQ@204432|Acidobacteriia	204432|Acidobacteriia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS2_k127_5475667_0	204669.Acid345_4550	1.008e-143	461.0	COG1210@1|root,COG1210@2|Bacteria,3Y39W@57723|Acidobacteria,2JHXA@204432|Acidobacteriia	204432|Acidobacteriia	M	UTP-glucose-1-phosphate uridylyltransferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_5475667_2	204669.Acid345_0231	2.148e-54	194.0	COG0151@1|root,COG0151@2|Bacteria,3Y47C@57723|Acidobacteria,2JIFR@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
TLS2_k127_5492006_3	204669.Acid345_0678	6.164e-89	309.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	yagE	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
TLS2_k127_5492006_1	234267.Acid_0925	4.672e-221	696.0	COG4147@1|root,COG4147@2|Bacteria	2|Bacteria	S	glycolate transport	ywcA	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	iAF987.Gmet_0739	SSF
TLS2_k127_5492006_5	234267.Acid_0924	4.233e-34	134.0	COG3162@1|root,COG3162@2|Bacteria	2|Bacteria	S	Protein of unknown function, DUF485	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
TLS2_k127_5492006_2	234267.Acid_5675	2.037e-150	490.0	COG0535@1|root,COG0535@2|Bacteria,3Y3QA@57723|Acidobacteria	57723|Acidobacteria	S	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
TLS2_k127_5492006_0	1382359.JIAL01000001_gene12	0.0	1261.0	COG1964@1|root,COG1964@2|Bacteria,3Y2WC@57723|Acidobacteria,2JHTH@204432|Acidobacteriia	204432|Acidobacteriia	S	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
TLS2_k127_5492006_4	234267.Acid_3571	1.38e-72	252.0	COG0558@1|root,COG0558@2|Bacteria,3Y4PW@57723|Acidobacteria	57723|Acidobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
TLS2_k127_5492006_6	234267.Acid_3570	1.753e-18	94.0	COG2246@1|root,COG2246@2|Bacteria,3Y5HC@57723|Acidobacteria	57723|Acidobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
TLS2_k127_551138_6	926550.CLDAP_28990	1.389e-101	343.0	COG0464@1|root,COG0464@2|Bacteria,2G87K@200795|Chloroflexi	200795|Chloroflexi	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
TLS2_k127_551138_2	204669.Acid345_3538	1.06e-165	526.0	COG1702@1|root,COG1702@2|Bacteria,3Y3RM@57723|Acidobacteria,2JI4V@204432|Acidobacteriia	204432|Acidobacteriia	T	PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
TLS2_k127_551138_11	204669.Acid345_3537	1.015e-30	128.0	COG0319@1|root,COG0319@2|Bacteria,3Y53R@57723|Acidobacteria,2JJPS@204432|Acidobacteriia	204432|Acidobacteriia	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
TLS2_k127_551138_3	204669.Acid345_3536	3.852e-138	452.0	COG1253@1|root,COG1253@2|Bacteria,3Y3MC@57723|Acidobacteria,2JIF9@204432|Acidobacteriia	204432|Acidobacteriia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_551138_5	204669.Acid345_3535	7.456e-122	398.0	COG1159@1|root,COG1159@2|Bacteria,3Y2GE@57723|Acidobacteria,2JIIA@204432|Acidobacteriia	204432|Acidobacteriia	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
TLS2_k127_551138_7	234267.Acid_7801	7.026e-47	175.0	COG4430@1|root,COG4430@2|Bacteria,3Y5HF@57723|Acidobacteria	57723|Acidobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
TLS2_k127_551138_4	234267.Acid_5337	3.545e-136	452.0	COG1520@1|root,COG1520@2|Bacteria,3Y613@57723|Acidobacteria	57723|Acidobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_551138_12	926569.ANT_13160	2.553e-08	65.0	COG1664@1|root,COG1664@2|Bacteria,2G7EZ@200795|Chloroflexi	200795|Chloroflexi	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS2_k127_551138_1	204669.Acid345_1394	1.08e-232	727.0	COG2204@1|root,COG2204@2|Bacteria,3Y2J1@57723|Acidobacteria,2JIIE@204432|Acidobacteriia	204432|Acidobacteriia	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_551138_0	204669.Acid345_1393	7.994e-280	880.0	COG5000@1|root,COG5000@2|Bacteria,3Y32D@57723|Acidobacteria,2JIN2@204432|Acidobacteriia	204432|Acidobacteriia	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
TLS2_k127_551138_9	1121451.DESAM_21635	7.219e-37	148.0	2C82G@1|root,32RK9@2|Bacteria,1MZV5@1224|Proteobacteria,42U4W@68525|delta/epsilon subdivisions,2WQ9S@28221|Deltaproteobacteria,2MCV4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
TLS2_k127_551138_8	1463885.KL578443_gene1531	2.385e-42	158.0	2E4PM@1|root,32ZI9@2|Bacteria,2IMT3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_551138_10	247490.KSU1_C0054	1.147e-32	132.0	COG2231@1|root,COG2231@2|Bacteria,2IZ9A@203682|Planctomycetes	203682|Planctomycetes	L	endonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
TLS2_k127_5526790_1	290317.Cpha266_1646	9.087e-33	129.0	COG2963@1|root,COG2963@2|Bacteria,1FFI3@1090|Chlorobi	1090|Chlorobi	L	PFAM transposase IS3 IS911 family protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
TLS2_k127_5526790_0	338963.Pcar_1381	1.832e-136	444.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,42MM6@68525|delta/epsilon subdivisions,2WJ53@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve
TLS2_k127_5632397_0	204669.Acid345_0231	1.689e-151	484.0	COG0151@1|root,COG0151@2|Bacteria,3Y47C@57723|Acidobacteria,2JIFR@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
TLS2_k127_5632397_1	1267535.KB906767_gene2307	4.161e-133	460.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	asmA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475	-	ko:K07289,ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA,AsmA_2
TLS2_k127_5632397_3	204669.Acid345_4135	2.321e-38	148.0	COG1734@1|root,COG1734@2|Bacteria,3Y5PJ@57723|Acidobacteria,2JK2N@204432|Acidobacteriia	204432|Acidobacteriia	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
TLS2_k127_5632397_2	585506.HMPREF0877_0802	9.232e-99	334.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,4H9PT@91061|Bacilli,4AWW2@81850|Leuconostocaceae	91061|Bacilli	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
TLS2_k127_5632397_4	234267.Acid_0320	5.626e-08	54.0	COG0235@1|root,COG0235@2|Bacteria,3Y4E0@57723|Acidobacteria	57723|Acidobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
TLS2_k127_5652667_0	204669.Acid345_2716	1.961e-43	177.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_5652667_1	861299.J421_5899	5.247e-14	85.0	COG0457@1|root,COG0823@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K03641,ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001,ko02000	2.C.1.2	-	-	DUF4214,Pkinase,SBBP,TPR_16,TPR_19,TPR_2,TPR_8
TLS2_k127_5652667_2	204669.Acid345_1205	1.709e-10	61.0	COG0124@1|root,COG0124@2|Bacteria,3Y3IY@57723|Acidobacteria,2JIRJ@204432|Acidobacteriia	204432|Acidobacteriia	J	synthetase, class II (G H P	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TLS2_k127_5676788_0	204669.Acid345_4304	7.003e-211	662.0	COG1249@1|root,COG1249@2|Bacteria,3Y2M8@57723|Acidobacteria,2JIAI@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_5676788_3	105420.BBPO01000045_gene1075	3.915e-57	205.0	COG0262@1|root,COG0262@2|Bacteria,2GKX0@201174|Actinobacteria,2NJUF@228398|Streptacidiphilus	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_5676788_2	1382359.JIAL01000001_gene1187	1.2e-85	291.0	COG0321@1|root,COG0321@2|Bacteria,3Y448@57723|Acidobacteria,2JIHP@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TLS2_k127_5676788_1	1267533.KB906740_gene330	3.757e-147	479.0	COG1071@1|root,COG1071@2|Bacteria,3Y4M3@57723|Acidobacteria	57723|Acidobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS2_k127_5750133_7	204669.Acid345_3992	2.391e-134	434.0	COG0215@1|root,COG0215@2|Bacteria,3Y2PW@57723|Acidobacteria,2JHIQ@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
TLS2_k127_5750133_9	204669.Acid345_3994	7.237e-85	293.0	COG0697@1|root,COG0697@2|Bacteria,3Y4NT@57723|Acidobacteria,2JJ8M@204432|Acidobacteriia	204432|Acidobacteriia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_5750133_1	204669.Acid345_3989	1.665e-218	687.0	COG0160@1|root,COG0160@2|Bacteria,3Y3P2@57723|Acidobacteria,2JIZJ@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class-III	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_5750133_15	1227488.C477_08463	2.44e-41	162.0	COG3217@1|root,arCOG04766@2157|Archaea,2Y7HS@28890|Euryarchaeota,241HM@183963|Halobacteria	183963|Halobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
TLS2_k127_5750133_3	1242864.D187_000828	3.424e-191	615.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,43BBS@68525|delta/epsilon subdivisions,2X6QY@28221|Deltaproteobacteria,2YU79@29|Myxococcales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS2_k127_5750133_16	204669.Acid345_3985	2.297e-39	154.0	COG0792@1|root,COG0792@2|Bacteria,3Y56J@57723|Acidobacteria,2JJU6@204432|Acidobacteriia	204432|Acidobacteriia	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
TLS2_k127_5750133_5	204669.Acid345_0343	1.915e-187	589.0	COG1085@1|root,COG1085@2|Bacteria,3Y41K@57723|Acidobacteria,2JMKJ@204432|Acidobacteriia	204432|Acidobacteriia	C	Domain of unknown function (DUF4921)	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C
TLS2_k127_5750133_20	279714.FuraDRAFT_0630	4.202e-09	59.0	2EFZF@1|root,339RM@2|Bacteria,1NH6S@1224|Proteobacteria,2VYEK@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5750133_17	204669.Acid345_0478	1.599e-26	110.0	COG2975@1|root,COG2975@2|Bacteria,3Y5I4@57723|Acidobacteria,2JJZY@204432|Acidobacteriia	204432|Acidobacteriia	S	FeS assembly protein IscX	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_assembly
TLS2_k127_5750133_12	204669.Acid345_0479	1.382e-56	200.0	COG0633@1|root,COG0633@2|Bacteria,3Y4T7@57723|Acidobacteria,2JJFT@204432|Acidobacteriia	204432|Acidobacteriia	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
TLS2_k127_5750133_0	204669.Acid345_0480	4.882e-303	940.0	COG0443@1|root,COG0443@2|Bacteria,3Y2F8@57723|Acidobacteria,2JIVF@204432|Acidobacteriia	204432|Acidobacteriia	O	heat shock protein 70	-	-	-	ko:K04043,ko:K04044	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33,1.A.33.1	-	-	HSP70
TLS2_k127_5750133_10	204669.Acid345_0481	1.065e-82	282.0	COG1076@1|root,COG1076@2|Bacteria,3Y4MR@57723|Acidobacteria,2JJBF@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM heat shock protein DnaJ	-	-	-	ko:K04082	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,HSCB_C
TLS2_k127_5750133_14	204669.Acid345_0482	2.432e-51	184.0	COG0316@1|root,COG0316@2|Bacteria,3Y518@57723|Acidobacteria,2JJGN@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TLS2_k127_5750133_11	926566.Terro_4158	1.471e-73	250.0	COG0822@1|root,COG0822@2|Bacteria,3Y4B9@57723|Acidobacteria,2JJ45@204432|Acidobacteriia	204432|Acidobacteriia	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS2_k127_5750133_2	204669.Acid345_0484	1.9e-215	674.0	COG1104@1|root,COG1104@2|Bacteria,3Y3CG@57723|Acidobacteria,2JI55@204432|Acidobacteriia	204432|Acidobacteriia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS2_k127_5750133_13	204669.Acid345_0485	1.256e-54	195.0	COG1959@1|root,COG1959@2|Bacteria,3Y4X0@57723|Acidobacteria,2JJEV@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TLS2_k127_5750133_8	204669.Acid345_0486	4.241e-114	381.0	COG1198@1|root,COG1198@2|Bacteria	2|Bacteria	L	DNA replication, synthesis of RNA primer	-	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DZR,zf-ribbon_3,zinc_ribbon_2
TLS2_k127_5750133_19	639030.JHVA01000001_gene3204	2.199e-10	63.0	2FKK0@1|root,34C6Z@2|Bacteria,3Y8U4@57723|Acidobacteria,2JNXC@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5750133_18	204669.Acid345_0488	6.566e-24	107.0	COG0745@1|root,COG0745@2|Bacteria	204669.Acid345_0488|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5750133_6	204669.Acid345_0494	1.306e-151	488.0	COG0533@1|root,COG0533@2|Bacteria,3Y2PN@57723|Acidobacteria,2JHJ0@204432|Acidobacteriia	204432|Acidobacteriia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TLS2_k127_5750133_4	204669.Acid345_0497	1.053e-187	596.0	COG0617@1|root,COG0617@2|Bacteria,3Y3B8@57723|Acidobacteria,2JIIS@204432|Acidobacteriia	204432|Acidobacteriia	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
TLS2_k127_5750722_5	485913.Krac_1224	1.967e-107	364.0	COG1680@1|root,COG1680@2|Bacteria,2G6QM@200795|Chloroflexi	2|Bacteria	V	COGs COG1680 Beta-lactamase class C and other penicillin binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_5750722_13	204669.Acid345_0498	1.648e-21	101.0	COG5512@1|root,COG5512@2|Bacteria	2|Bacteria	L	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
TLS2_k127_5750722_11	204669.Acid345_0499	3.617e-28	122.0	COG0721@1|root,COG0721@2|Bacteria,3Y5QA@57723|Acidobacteria,2JNA0@204432|Acidobacteriia	204432|Acidobacteriia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
TLS2_k127_5750722_1	204669.Acid345_0501	3.172e-232	726.0	COG0154@1|root,COG0154@2|Bacteria,3Y2PE@57723|Acidobacteria,2JIE0@204432|Acidobacteriia	204432|Acidobacteriia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_5750722_10	1382359.JIAL01000001_gene1399	1.23e-37	152.0	2A9EB@1|root,30YJQ@2|Bacteria,3Y4PM@57723|Acidobacteria,2JJ9K@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5750722_3	204669.Acid345_0504	5.851e-149	477.0	COG3437@1|root,COG3437@2|Bacteria,3Y6BB@57723|Acidobacteria,2JKVT@204432|Acidobacteriia	204432|Acidobacteriia	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD_5,Response_reg
TLS2_k127_5750722_6	204669.Acid345_0505	4.236e-98	330.0	COG0463@1|root,COG0463@2|Bacteria,3Y982@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_5750722_9	1356852.N008_20540	4.709e-38	150.0	2DTU1@1|root,33MMF@2|Bacteria,4NWD8@976|Bacteroidetes,47SX0@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5750722_0	204669.Acid345_1048	0.0	1002.0	COG2987@1|root,COG2987@2|Bacteria,3Y2VD@57723|Acidobacteria,2JK4Z@204432|Acidobacteriia	204432|Acidobacteriia	E	Urocanase Rossmann-like domain	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
TLS2_k127_5750722_4	204669.Acid345_1049	2.165e-145	472.0	COG1228@1|root,COG1228@2|Bacteria,3Y3BK@57723|Acidobacteria,2JKVY@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS2_k127_5750722_2	204669.Acid345_2833	3.841e-209	661.0	COG0677@1|root,COG0677@2|Bacteria,3Y30B@57723|Acidobacteria,2JIIN@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.136	ko:K13015	ko00520,map00520	-	R00421	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS2_k127_5750722_12	1167006.UWK_01778	9.536e-26	121.0	COG1493@1|root,COG1493@2|Bacteria,1NN8Y@1224|Proteobacteria,43324@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5750722_8	395961.Cyan7425_1024	1.172e-45	180.0	COG4076@1|root,COG4076@2|Bacteria,1G4RK@1117|Cyanobacteria	1117|Cyanobacteria	J	PRMT5 arginine-N-methyltransferase	-	-	2.1.1.319	ko:K11434	ko04068,ko04922,map04068,map04922	-	R11216,R11217,R11219	RC00003,RC02120,RC03388,RC03390	ko00000,ko00001,ko01000,ko03036	-	-	-	PRMT5_C,PrmA
TLS2_k127_5750722_7	1167006.UWK_01777	1.521e-89	319.0	COG0367@1|root,COG0367@2|Bacteria,1R77U@1224|Proteobacteria,4305Y@68525|delta/epsilon subdivisions,2WVE7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
TLS2_k127_5799302_11	861299.J421_4298	2.018e-32	134.0	COG2132@1|root,COG2132@2|Bacteria,1ZUD9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22348	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
TLS2_k127_5799302_9	861299.J421_0475	6.283e-60	229.0	COG1595@1|root,COG1595@2|Bacteria,1ZUZ9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_5799302_0	861299.J421_0476	7.196e-287	910.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZTK4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
TLS2_k127_5799302_6	909663.KI867150_gene2720	3.895e-85	299.0	COG0535@1|root,COG0535@2|Bacteria,1Q6NI@1224|Proteobacteria,433FI@68525|delta/epsilon subdivisions,2WXJT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_5799302_1	321327.CYA_2657	4.367e-174	549.0	COG1899@1|root,COG1899@2|Bacteria,1GCEV@1117|Cyanobacteria,1H3XV@1129|Synechococcus	1117|Cyanobacteria	O	Hypusine is a modified amino acid found in eukarya and archaea, but as yet	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
TLS2_k127_5799302_8	234267.Acid_0954	2.455e-65	239.0	COG1408@1|root,COG1408@2|Bacteria,3Y5PS@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
TLS2_k127_5799302_12	240015.ACP_1768	1.65e-23	103.0	COG1605@1|root,COG1605@2|Bacteria,3Y53J@57723|Acidobacteria,2JJUZ@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Chorismate mutase, type II	-	-	-	-	-	-	-	-	-	-	-	-	CM_2
TLS2_k127_5799302_2	240015.ACP_1767	4.811e-163	518.0	COG2876@1|root,COG2876@2|Bacteria,3Y2SV@57723|Acidobacteria,2JHNF@204432|Acidobacteriia	204432|Acidobacteriia	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
TLS2_k127_5799302_7	204669.Acid345_1162	9.376e-82	280.0	COG0287@1|root,COG0287@2|Bacteria,3Y4CK@57723|Acidobacteria,2JJ49@204432|Acidobacteriia	204432|Acidobacteriia	E	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
TLS2_k127_5799302_5	204669.Acid345_1163	1.6e-111	363.0	COG1788@1|root,COG1788@2|Bacteria,3Y3R1@57723|Acidobacteria,2JISA@204432|Acidobacteriia	204432|Acidobacteriia	I	Coenzyme A transferase	-	-	2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS2_k127_5799302_4	204669.Acid345_1164	2.642e-118	383.0	COG2057@1|root,COG2057@2|Bacteria,3Y3EC@57723|Acidobacteria,2JIV4@204432|Acidobacteriia	204432|Acidobacteriia	I	Coenzyme A transferase	-	-	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS2_k127_5799302_14	316067.Geob_0343	1.38e-19	98.0	2E32S@1|root,32Y2Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5799302_13	290397.Adeh_2802	5.206e-20	93.0	2EK70@1|root,33DXD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5799302_3	204669.Acid345_1175	8.563e-157	500.0	COG0182@1|root,COG0182@2|Bacteria,3Y2TR@57723|Acidobacteria,2JHZX@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
TLS2_k127_5868676_3	868131.MSWAN_0569	2.046e-36	145.0	COG0119@1|root,arCOG02092@2157|Archaea,2XV8D@28890|Euryarchaeota,23PFQ@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	aksA	-	2.3.3.14	ko:K10977	ko00300,ko00620,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00620,map00680,map01100,map01120,map01130,map01210,map01230	M00608	R00271,R08213,R08331,R08332	RC00004,RC00067,RC02149,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS2_k127_5868676_1	1380390.JIAT01000012_gene3239	1.86e-107	357.0	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria,4CRDW@84995|Rubrobacteria	84995|Rubrobacteria	Q	Domain of unknown function (DUF2437)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
TLS2_k127_5868676_0	204669.Acid345_2526	7.264e-145	473.0	COG1252@1|root,COG1252@2|Bacteria,3Y308@57723|Acidobacteria,2JI43@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_5868676_2	1340493.JNIF01000003_gene1854	1.292e-85	300.0	2AHFT@1|root,317T3@2|Bacteria,3Y8T4@57723|Acidobacteria	1340493.JNIF01000003_gene1854|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5868676_4	1267533.KB906734_gene4265	2.945e-10	62.0	COG1947@1|root,COG1947@2|Bacteria,3Y2QX@57723|Acidobacteria,2JIDT@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_5870032_4	234267.Acid_2471	1.409e-23	117.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	234267.Acid_2471|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
TLS2_k127_5870032_1	204669.Acid345_1206	1.435e-81	274.0	COG0663@1|root,COG0663@2|Bacteria,3Y4A5@57723|Acidobacteria,2JJ1R@204432|Acidobacteriia	204432|Acidobacteriia	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
TLS2_k127_5870032_3	278963.ATWD01000001_gene1278	3.687e-61	222.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
TLS2_k127_5870032_2	1267535.KB906767_gene3275	3.278e-65	250.0	COG0457@1|root,COG0457@2|Bacteria,3Y7UM@57723|Acidobacteria,2JNRM@204432|Acidobacteriia	204432|Acidobacteriia	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5870032_0	234267.Acid_3963	5.427e-102	362.0	COG1629@1|root,COG4771@2|Bacteria,3Y2HF@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_5870032_5	204669.Acid345_1501	9.24e-05	48.0	COG1629@1|root,COG4771@2|Bacteria,3Y3W1@57723|Acidobacteria,2JIP5@204432|Acidobacteriia	204432|Acidobacteriia	P	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_5928878_2	234267.Acid_3885	9.072e-55	194.0	COG1245@1|root,COG1245@2|Bacteria	2|Bacteria	C	4Fe-4S binding domain	rnfB	-	1.8.99.2	ko:K00395,ko:K02572,ko:K03616	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FeS,Fer4,Fer4_4,Fer4_7
TLS2_k127_5928878_0	234267.Acid_0922	0.0	1776.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,3Y7VB@57723|Acidobacteria	57723|Acidobacteria	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
TLS2_k127_5928878_1	234267.Acid_0921	2.498e-273	852.0	COG3581@1|root,COG3581@2|Bacteria	2|Bacteria	I	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5928878_3	204669.Acid345_2178	3.276e-45	186.0	2E93F@1|root,333CD@2|Bacteria,3Y98Q@57723|Acidobacteria,2JP57@204432|Acidobacteriia	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5928878_5	204669.Acid345_2180	7.479e-31	140.0	2E93F@1|root,333CD@2|Bacteria,3Y98Q@57723|Acidobacteria,2JP57@204432|Acidobacteriia	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5928878_6	234267.Acid_5255	2.278e-20	92.0	2B11W@1|root,31TFA@2|Bacteria,3Y4Z8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5937776_14	204669.Acid345_3868	6.897e-65	227.0	COG0104@1|root,COG0104@2|Bacteria,3Y2Z9@57723|Acidobacteria,2JIIV@204432|Acidobacteriia	204432|Acidobacteriia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
TLS2_k127_5937776_8	401053.AciPR4_3426	1.468e-102	340.0	COG0266@1|root,COG0266@2|Bacteria,3Y39U@57723|Acidobacteria,2JI11@204432|Acidobacteriia	204432|Acidobacteriia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_5937776_6	204669.Acid345_3865	1.374e-126	413.0	COG1940@1|root,COG1940@2|Bacteria,3Y4DD@57723|Acidobacteria,2JJ4T@204432|Acidobacteriia	204432|Acidobacteriia	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_5937776_4	204669.Acid345_3864	4.281e-128	419.0	COG0079@1|root,COG0079@2|Bacteria,3Y4H9@57723|Acidobacteria,2JMT4@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class-V	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_5937776_9	1382359.JIAL01000001_gene2959	7.291e-96	321.0	COG1187@1|root,COG1187@2|Bacteria,3Y3CQ@57723|Acidobacteria,2JHMG@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_5937776_15	204669.Acid345_3873	7.562e-65	228.0	COG0105@1|root,COG0105@2|Bacteria,3Y4MW@57723|Acidobacteria,2JJD4@204432|Acidobacteriia	204432|Acidobacteriia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
TLS2_k127_5937776_3	204669.Acid345_3874	1.298e-141	454.0	COG0074@1|root,COG0074@2|Bacteria,3Y3UX@57723|Acidobacteria,2JHSN@204432|Acidobacteriia	204432|Acidobacteriia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
TLS2_k127_5937776_2	204669.Acid345_3875	3.687e-186	591.0	COG0045@1|root,COG0045@2|Bacteria,3Y36X@57723|Acidobacteria,2JHR1@204432|Acidobacteriia	204432|Acidobacteriia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
TLS2_k127_5937776_13	1003200.AXXA_24430	4.192e-67	234.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2VTAV@28216|Betaproteobacteria,3T3PW@506|Alcaligenaceae	28216|Betaproteobacteria	J	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_5937776_12	1382359.JIAL01000001_gene2653	1.444e-77	266.0	COG0566@1|root,COG0566@2|Bacteria,3Y3XM@57723|Acidobacteria,2JII0@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS2_k127_5937776_17	1379698.RBG1_1C00001G0055	5.813e-42	167.0	COG0671@1|root,COG0671@2|Bacteria,2NRVZ@2323|unclassified Bacteria	2|Bacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
TLS2_k127_5937776_7	445335.CBN_3246	4.183e-120	397.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,36DVG@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the thiolase family	thlA2	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_5937776_16	926566.Terro_3967	4.36e-48	179.0	COG1595@1|root,COG1595@2|Bacteria,3Y45G@57723|Acidobacteria,2JIQI@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_5937776_18	401053.AciPR4_3548	6.453e-33	134.0	COG1040@1|root,COG1040@2|Bacteria,3Y5KW@57723|Acidobacteria,2JMCD@204432|Acidobacteriia	204432|Acidobacteriia	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	DZR,PLDc_N
TLS2_k127_5937776_5	204669.Acid345_1001	1.897e-127	411.0	COG3279@1|root,COG3279@2|Bacteria,3Y3HR@57723|Acidobacteria,2JIXA@204432|Acidobacteriia	204432|Acidobacteriia	T	Two component transcriptional regulator, LytTR family	-	-	-	ko:K02477,ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
TLS2_k127_5937776_19	204669.Acid345_0998	7.038e-32	126.0	COG1828@1|root,COG1828@2|Bacteria,3Y5NE@57723|Acidobacteria,2JJWM@204432|Acidobacteriia	204432|Acidobacteriia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
TLS2_k127_5937776_1	204669.Acid345_0997	7.195e-317	979.0	COG0449@1|root,COG0449@2|Bacteria,3Y2NE@57723|Acidobacteria,2JI69@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
TLS2_k127_5937776_11	1382359.JIAL01000001_gene1001	1.234e-79	272.0	COG1018@1|root,COG1018@2|Bacteria,3Y4SB@57723|Acidobacteria,2JJAW@204432|Acidobacteriia	204432|Acidobacteriia	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
TLS2_k127_5937776_0	240015.ACP_0797	0.0	1034.0	COG0443@1|root,COG0443@2|Bacteria,3Y2XU@57723|Acidobacteria,2JHT1@204432|Acidobacteriia	204432|Acidobacteriia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TLS2_k127_5937776_20	1042377.AFPJ01000034_gene2339	1.186e-28	121.0	2CD3D@1|root,32RWZ@2|Bacteria,1N61G@1224|Proteobacteria,1SB8Q@1236|Gammaproteobacteria,46BJ4@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_5937776_10	278963.ATWD01000001_gene4238	2.94e-84	285.0	COG0484@1|root,COG0484@2|Bacteria,3Y2XW@57723|Acidobacteria,2JHWV@204432|Acidobacteriia	204432|Acidobacteriia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_5937903_7	204669.Acid345_3920	1.256e-15	78.0	COG1063@1|root,COG1063@2|Bacteria,3Y3KU@57723|Acidobacteria,2JIQ4@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_5937903_5	204669.Acid345_1805	4.402e-31	124.0	COG2151@1|root,COG2151@2|Bacteria,3Y5G8@57723|Acidobacteria,2JP2G@204432|Acidobacteriia	204432|Acidobacteriia	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
TLS2_k127_5937903_8	909613.UO65_0574	1.886e-11	75.0	COG3794@1|root,COG3794@2|Bacteria,2IR44@201174|Actinobacteria	201174|Actinobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5937903_3	1242864.D187_000932	4.604e-84	297.0	COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria	1224|Proteobacteria	G	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS2_k127_5937903_4	204669.Acid345_3922	3.001e-44	164.0	COG0789@1|root,COG0789@2|Bacteria,3Y56I@57723|Acidobacteria,2JJNQ@204432|Acidobacteriia	204432|Acidobacteriia	K	Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_5937903_12	261292.Nit79A3_2343	4.963e-05	54.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	Laminin_G_3,PKD,TIG,TPP_enzyme_M,fn3
TLS2_k127_5937903_1	1267535.KB906767_gene2893	1.331e-122	409.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07712,ko:K07713	ko02020,map02020	M00497,M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_5937903_10	278963.ATWD01000001_gene2589	1.617e-05	50.0	COG0789@1|root,COG0789@2|Bacteria,3Y56I@57723|Acidobacteria,2JJNQ@204432|Acidobacteriia	204432|Acidobacteriia	K	Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_5937903_9	204669.Acid345_3922	1.266e-08	61.0	COG0789@1|root,COG0789@2|Bacteria,3Y56I@57723|Acidobacteria,2JJNQ@204432|Acidobacteriia	204432|Acidobacteriia	K	Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_5937903_2	1267533.KB906737_gene1831	4.98e-112	394.0	COG3485@1|root,COG3511@1|root,COG3485@2|Bacteria,COG3511@2|Bacteria,3Y7AQ@57723|Acidobacteria,2JM7S@204432|Acidobacteriia	204432|Acidobacteriia	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
TLS2_k127_5937903_0	204669.Acid345_3921	2.771e-242	759.0	COG0146@1|root,COG0146@2|Bacteria,3Y6W2@57723|Acidobacteria,2JKCE@204432|Acidobacteriia	204432|Acidobacteriia	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
TLS2_k127_5937903_11	1111732.AZOD01000033_gene741	4.89e-05	46.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,1S8WZ@1236|Gammaproteobacteria,1X7HF@135614|Xanthomonadales	135614|Xanthomonadales	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
TLS2_k127_5937903_6	882082.SaccyDRAFT_2844	2.663e-22	101.0	COG2764@1|root,COG2764@2|Bacteria,2IFK2@201174|Actinobacteria,4ECD8@85010|Pseudonocardiales	201174|Actinobacteria	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_5941265_0	204669.Acid345_2701	1.704e-164	529.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_5941265_1	204669.Acid345_1791	1.042e-128	423.0	COG1748@1|root,COG1748@2|Bacteria,3Y84N@57723|Acidobacteria	57723|Acidobacteria	E	Saccharopine dehydrogenase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
TLS2_k127_5941265_3	861299.J421_0827	1.269e-15	83.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	catD	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
TLS2_k127_5941265_2	204669.Acid345_2272	4.579e-81	282.0	COG2010@1|root,COG2010@2|Bacteria,3Y5ZT@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
TLS2_k127_5941265_5	8083.ENSXMAP00000019965	0.0004828	44.0	KOG2287@1|root,KOG2287@2759|Eukaryota,39R1Q@33154|Opisthokonta,3BGFS@33208|Metazoa,3D2PA@33213|Bilateria,48BAF@7711|Chordata,497M5@7742|Vertebrata,49Z0V@7898|Actinopterygii	33208|Metazoa	G	UDP-Gal betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4	B3GALT4	GO:0000139,GO:0001573,GO:0001574,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006688,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008499,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030148,GO:0031090,GO:0031984,GO:0034641,GO:0035250,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0046467,GO:0046513,GO:0048531,GO:0071704,GO:0098588,GO:0098791,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509	2.4.1.206,2.4.1.62	ko:K00715,ko:K03766	ko00601,ko00604,ko01100,map00601,map00604,map01100	M00070,M00071	R05941,R05948,R05953,R05956,R05971	-	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT31	-	Galactosyl_T
TLS2_k127_5941265_4	1267534.KB906755_gene4189	3.888e-14	72.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,3Y34Y@57723|Acidobacteria,2JHQ9@204432|Acidobacteriia	204432|Acidobacteriia	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
TLS2_k127_5986478_3	1267533.KB906735_gene4549	1.67e-139	476.0	COG0515@1|root,COG0515@2|Bacteria,3Y3HX@57723|Acidobacteria,2JHJ9@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,TPR_8
TLS2_k127_5986478_0	1382359.JIAL01000001_gene912	4.339e-215	683.0	COG0591@1|root,COG0591@2|Bacteria,3Y4WN@57723|Acidobacteria,2JJVD@204432|Acidobacteriia	204432|Acidobacteriia	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_5986478_8	886293.Sinac_5029	1.234e-101	339.0	COG1878@1|root,COG1878@2|Bacteria,2IZXG@203682|Planctomycetes	203682|Planctomycetes	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_5986478_11	234267.Acid_1857	2.318e-39	153.0	COG0735@1|root,COG0735@2|Bacteria,3Y5IN@57723|Acidobacteria	57723|Acidobacteria	P	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_5986478_1	190650.CC_0139	2.466e-185	606.0	COG4772@1|root,COG4772@2|Bacteria,1MWDG@1224|Proteobacteria,2U4AH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG4772 Outer membrane receptor for Fe3 -dicitrate	-	-	-	ko:K16091	-	-	-	-	ko00000,ko02000	1.B.14.1.14	-	-	Plug,TonB_dep_Rec
TLS2_k127_5986478_4	240015.ACP_2716	6.831e-138	457.0	COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y45M@57723|Acidobacteria,2JIBX@204432|Acidobacteriia	204432|Acidobacteriia	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF_2,SpoIIE
TLS2_k127_5986478_5	1403819.BATR01000146_gene4994	2.066e-126	421.0	COG1473@1|root,COG1473@2|Bacteria,46V61@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_5986478_9	204669.Acid345_2971	2e-97	323.0	COG0704@1|root,COG0704@2|Bacteria,3Y4DI@57723|Acidobacteria,2JJ5M@204432|Acidobacteriia	204432|Acidobacteriia	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TLS2_k127_5986478_6	204669.Acid345_2972	7.451e-124	400.0	COG1117@1|root,COG1117@2|Bacteria,3Y35A@57723|Acidobacteria,2JI8F@204432|Acidobacteriia	204432|Acidobacteriia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TLS2_k127_5986478_7	204669.Acid345_2973	1.879e-118	388.0	COG0581@1|root,COG0581@2|Bacteria,3Y3JF@57723|Acidobacteria,2JHVP@204432|Acidobacteriia	204432|Acidobacteriia	P	Phosphate transport system permease protein PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS2_k127_5986478_2	204669.Acid345_2974	1.401e-146	471.0	COG0573@1|root,COG0573@2|Bacteria,3Y42Y@57723|Acidobacteria,2JIJN@204432|Acidobacteriia	204432|Acidobacteriia	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS2_k127_5986478_10	204669.Acid345_0831	1.738e-74	268.0	COG3746@1|root,COG3746@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Porin_5
TLS2_k127_5986478_12	204669.Acid345_2975	5.38e-21	94.0	COG0226@1|root,COG0226@2|Bacteria,3Y399@57723|Acidobacteria,2JIVU@204432|Acidobacteriia	204432|Acidobacteriia	P	Belongs to the PstS family	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
TLS2_k127_6040751_5	891968.Anamo_1244	1.758e-112	369.0	COG0428@1|root,COG0428@2|Bacteria,3T9UW@508458|Synergistetes	508458|Synergistetes	P	PFAM zinc iron permease	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
TLS2_k127_6040751_14	1295642.H839_01966	1.4e-21	102.0	COG0517@1|root,COG0517@2|Bacteria,1V9ZB@1239|Firmicutes,4HHZP@91061|Bacilli,1WGA6@129337|Geobacillus	91061|Bacilli	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_6040751_12	401053.AciPR4_3838	6.802e-32	131.0	COG3477@1|root,COG3477@2|Bacteria,3Y8IX@57723|Acidobacteria,2JNGH@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1440
TLS2_k127_6040751_15	330214.NIDE1855	5.799e-15	78.0	COG2331@1|root,COG2331@2|Bacteria	2|Bacteria	P	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TLS2_k127_6040751_4	204669.Acid345_1010	5.799e-113	373.0	COG0429@1|root,COG0429@2|Bacteria,3Y3MP@57723|Acidobacteria,2JI5X@204432|Acidobacteriia	204432|Acidobacteriia	S	Serine aminopeptidase, S33	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
TLS2_k127_6040751_13	204669.Acid345_1011	1.742e-29	124.0	2C5N9@1|root,32RFX@2|Bacteria,3Y4SQ@57723|Acidobacteria,2JJEZ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6040751_0	204669.Acid345_1131	3.037e-202	642.0	COG1960@1|root,COG1960@2|Bacteria,3Y32R@57723|Acidobacteria,2JIRM@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1,1.3.99.12	ko:K00248,ko:K09478	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_6040751_3	204669.Acid345_3556	5.557e-118	389.0	COG0457@1|root,COG0457@2|Bacteria,3Y3EM@57723|Acidobacteria,2JIDA@204432|Acidobacteriia	204432|Acidobacteriia	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TPR_11,TPR_16,TPR_2,TPR_8
TLS2_k127_6040751_8	204669.Acid345_1152	7.128e-77	270.0	29QWH@1|root,30BWY@2|Bacteria,3Y4SG@57723|Acidobacteria,2JJDK@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6040751_1	1382359.JIAL01000001_gene480	3.299e-186	603.0	COG0860@1|root,COG0860@2|Bacteria,3Y3M0@57723|Acidobacteria,2JI9V@204432|Acidobacteriia	204432|Acidobacteriia	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
TLS2_k127_6040751_9	204669.Acid345_1154	2.008e-65	236.0	COG0741@1|root,COG0741@2|Bacteria,3Y84I@57723|Acidobacteria,2JNI1@204432|Acidobacteriia	204432|Acidobacteriia	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TLS2_k127_6040751_6	243231.GSU2357	6.75e-107	358.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,43C4Y@68525|delta/epsilon subdivisions,2X7FA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
TLS2_k127_6040751_10	1267533.KB906736_gene960	7.559e-54	194.0	2A52F@1|root,30N7U@2|Bacteria,3Y80I@57723|Acidobacteria,2JN1S@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6040751_16	1121904.ARBP01000005_gene4857	0.000148	51.0	2CIAQ@1|root,2ZXJG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6040751_11	1250232.JQNJ01000001_gene269	6.077e-36	140.0	COG0662@1|root,COG0662@2|Bacteria,4NTZN@976|Bacteroidetes	976|Bacteroidetes	G	ARD/ARD' family	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_6040751_2	204669.Acid345_3983	3.634e-186	590.0	COG0013@1|root,COG0013@2|Bacteria,3Y359@57723|Acidobacteria,2JIIR@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS2_k127_6050103_2	665942.HMPREF1022_00590	3.226e-09	62.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P8Q@68525|delta/epsilon subdivisions,2WK2B@28221|Deltaproteobacteria,2MABU@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K11384	ko02020,map02020	M00505	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_6050103_3	1088721.NSU_4396	2.754e-06	57.0	2DPIB@1|root,3326Z@2|Bacteria,1NHPZ@1224|Proteobacteria,2UTAH@28211|Alphaproteobacteria,2KAT0@204457|Sphingomonadales	204457|Sphingomonadales	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
TLS2_k127_6050103_0	639030.JHVA01000001_gene3241	1.919e-113	394.0	COG0457@1|root,COG0457@2|Bacteria,3Y6J0@57723|Acidobacteria,2JKHK@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
TLS2_k127_6050103_1	639030.JHVA01000001_gene3260	5.608e-103	345.0	COG2204@1|root,COG2204@2|Bacteria,3Y4B7@57723|Acidobacteria,2JJ5G@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Sigma54_activat
TLS2_k127_6090452_6	204669.Acid345_4220	4.793e-107	352.0	COG1073@1|root,COG1073@2|Bacteria,3Y99D@57723|Acidobacteria,2JP5P@204432|Acidobacteriia	204432|Acidobacteriia	S	Abhydrolase domain containing 18	-	-	-	-	-	-	-	-	-	-	-	-	DUF2048
TLS2_k127_6090452_5	204669.Acid345_1262	9.039e-119	387.0	COG1024@1|root,COG1024@2|Bacteria,3Y47B@57723|Acidobacteria,2JIRS@204432|Acidobacteriia	57723|Acidobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.100,4.2.1.17	ko:K01715,ko:K07537	ko00362,ko00650,ko01100,ko01120,ko01200,ko01220,map00362,map00650,map01100,map01120,map01200,map01220	M00541	R03026,R05597	RC00831,RC03168	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_6090452_2	204669.Acid345_0722	9.892e-162	519.0	COG0577@1|root,COG0577@2|Bacteria,3Y3XI@57723|Acidobacteria,2JI94@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_6090452_4	204669.Acid345_0721	2.772e-154	498.0	COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria,2JI8C@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_6090452_7	401053.AciPR4_4055	1.848e-89	311.0	COG1215@1|root,COG1215@2|Bacteria,3Y2JE@57723|Acidobacteria,2JINZ@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM hopanoid biosynthesis associated glycosyl transferase protein HpnI	-	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
TLS2_k127_6090452_8	204669.Acid345_1263	4.887e-50	184.0	COG0698@1|root,COG0698@2|Bacteria,3Y50S@57723|Acidobacteria,2JJEK@204432|Acidobacteriia	2|Bacteria	G	Ribose/Galactose Isomerase	rpiB	GO:0003674,GO:0003824,GO:0004751,GO:0005975,GO:0008150,GO:0008152,GO:0009056,GO:0009743,GO:0009758,GO:0009987,GO:0010033,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0042221,GO:0044238,GO:0050896,GO:0051716,GO:0070887,GO:0071310,GO:0071322,GO:0071704,GO:1901575,GO:1901700,GO:1901701	5.3.1.26,5.3.1.34,5.3.1.6	ko:K01808,ko:K01819,ko:K21911	ko00030,ko00051,ko00052,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00052,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R03240,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO3353	DUF3666,LacAB_rpiB
TLS2_k127_6090452_9	234267.Acid_7924	2.158e-44	169.0	2BMF1@1|root,32FZM@2|Bacteria,3Y8ZK@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6090452_0	204669.Acid345_1264	1.397e-216	679.0	COG0112@1|root,COG0112@2|Bacteria,3Y2JB@57723|Acidobacteria,2JI87@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TLS2_k127_6090452_1	479434.Sthe_2480	3.748e-165	552.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
TLS2_k127_6090452_3	204669.Acid345_1265	1.158e-155	501.0	COG0438@1|root,COG0438@2|Bacteria,3Y58K@57723|Acidobacteria,2JJTZ@204432|Acidobacteriia	204432|Acidobacteriia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_6111034_34	1341151.ASZU01000015_gene2104	5.827e-39	151.0	COG0346@1|root,COG0346@2|Bacteria,1V6K2@1239|Firmicutes,4HJ55@91061|Bacilli,27CW5@186824|Thermoactinomycetaceae	91061|Bacilli	E	Glyoxalase-like domain	cadI	GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
TLS2_k127_6111034_24	204669.Acid345_2131	4.883e-82	286.0	28M52@1|root,2ZAIX@2|Bacteria,3Y2MW@57723|Acidobacteria,2JIXK@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6111034_5	204669.Acid345_2130	8.111e-226	709.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,3Y3HP@57723|Acidobacteria,2JIP9@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Formiminotransferase domain	-	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_N
TLS2_k127_6111034_41	1382359.JIAL01000001_gene2822	2.828e-31	136.0	2DBI6@1|root,2Z9EP@2|Bacteria,3Y376@57723|Acidobacteria,2JIZQ@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Lipid A	-	-	-	-	-	-	-	-	-	-	-	-	PagL
TLS2_k127_6111034_17	204669.Acid345_2125	6.079e-120	389.0	COG0217@1|root,COG0217@2|Bacteria,3Y2UW@57723|Acidobacteria,2JIJW@204432|Acidobacteriia	204432|Acidobacteriia	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TLS2_k127_6111034_38	204669.Acid345_2234	7.763e-35	147.0	COG0628@1|root,COG0628@2|Bacteria,3Y4Y1@57723|Acidobacteria,2JJJY@204432|Acidobacteriia	204432|Acidobacteriia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_6111034_15	240015.ACP_0725	5.732e-121	391.0	COG0047@1|root,COG0047@2|Bacteria,3Y2YN@57723|Acidobacteria,2JIBA@204432|Acidobacteriia	204432|Acidobacteriia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
TLS2_k127_6111034_49	204669.Acid345_3555	3.947e-25	114.0	COG2823@1|root,COG2823@2|Bacteria,3Y8WE@57723|Acidobacteria	57723|Acidobacteria	S	BON domain	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
TLS2_k127_6111034_9	204669.Acid345_2236	1.104e-180	571.0	COG1052@1|root,COG1052@2|Bacteria,3Y8C1@57723|Acidobacteria,2JNCS@204432|Acidobacteriia	204432|Acidobacteriia	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_6111034_7	204669.Acid345_2243	2.252e-190	604.0	COG0436@1|root,COG0436@2|Bacteria,3Y3DG@57723|Acidobacteria,2JMAM@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS2_k127_6111034_2	1382359.JIAL01000001_gene121	1.6e-261	824.0	COG1770@1|root,COG1770@2|Bacteria,3Y3PK@57723|Acidobacteria,2JIWT@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM peptidase S9A prolyl oligopeptidase domain protein beta-propeller	-	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_6111034_11	518766.Rmar_0074	4.153e-169	563.0	COG2866@1|root,COG2866@2|Bacteria,4NEJA@976|Bacteroidetes,1FIRV@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Secreted protein containing N-terminal Zinc-dependent carboxypeptidase related domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Peptidase_M14
TLS2_k127_6111034_20	234267.Acid_6386	3.322e-108	365.0	COG2159@1|root,COG2159@2|Bacteria,3Y2PY@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_6111034_39	1461580.CCAS010000029_gene2747	2.049e-34	141.0	COG0642@1|root,COG2205@2|Bacteria,1UEIC@1239|Firmicutes,4HDD8@91061|Bacilli,1ZAQA@1386|Bacillus	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,MHYT,PAS_4,Response_reg
TLS2_k127_6111034_30	234267.Acid_3487	4.604e-47	177.0	COG0526@1|root,COG0526@2|Bacteria,3Y5DD@57723|Acidobacteria	57723|Acidobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_6111034_58	1382359.JIAL01000001_gene1962	0.000154	49.0	COG0669@1|root,COG0669@2|Bacteria,3Y4B6@57723|Acidobacteria,2JJ6A@204432|Acidobacteriia	204432|Acidobacteriia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_6111034_21	526227.Mesil_0745	8.785e-92	316.0	COG0010@1|root,COG0010@2|Bacteria,1WIEY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the arginase family	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS2_k127_6111034_47	639030.JHVA01000001_gene2452	7.466e-29	123.0	COG1633@1|root,COG1633@2|Bacteria,3Y5HE@57723|Acidobacteria,2JK0C@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF2383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2383
TLS2_k127_6111034_13	204669.Acid345_1889	2.787e-157	501.0	COG2404@1|root,COG2404@2|Bacteria,3Y98M@57723|Acidobacteria,2JP53@204432|Acidobacteriia	204432|Acidobacteriia	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6111034_51	1198114.AciX9_0745	6.339e-24	106.0	COG4818@1|root,COG4818@2|Bacteria,3Y5MZ@57723|Acidobacteria,2JK19@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870,zinc_ribbon_2
TLS2_k127_6111034_3	204669.Acid345_3370	4.362e-259	823.0	COG2366@1|root,COG2366@2|Bacteria,3Y2PX@57723|Acidobacteria,2JHKH@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS2_k127_6111034_37	1382359.JIAL01000001_gene527	6.123e-35	148.0	28KXA@1|root,2ZADA@2|Bacteria,3Y3TW@57723|Acidobacteria,2JIVI@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6111034_46	204669.Acid345_3427	1.202e-29	121.0	COG1722@1|root,COG1722@2|Bacteria,3Y5H0@57723|Acidobacteria,2JK24@204432|Acidobacteriia	204432|Acidobacteriia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
TLS2_k127_6111034_16	204669.Acid345_3432	7.696e-121	399.0	COG0142@1|root,COG0142@2|Bacteria,3Y2HS@57723|Acidobacteria,2JIPK@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_6111034_19	204669.Acid345_3433	7.333e-109	356.0	COG2120@1|root,COG2120@2|Bacteria,3Y3NP@57723|Acidobacteria,2JIEH@204432|Acidobacteriia	204432|Acidobacteriia	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_6111034_27	1340493.JNIF01000004_gene110	1.001e-65	240.0	COG3137@1|root,COG3137@2|Bacteria	2|Bacteria	-	-	ydiY	-	-	ko:K07283	-	-	-	-	ko00000	-	-	-	DUF3078,DUF481
TLS2_k127_6111034_53	443143.GM18_2812	2.683e-21	101.0	2DXYI@1|root,34771@2|Bacteria,1P0DZ@1224|Proteobacteria,431TH@68525|delta/epsilon subdivisions,2WX2S@28221|Deltaproteobacteria,43VCH@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6111034_22	204669.Acid345_2148	1.399e-85	288.0	COG0807@1|root,COG0807@2|Bacteria,3Y2I4@57723|Acidobacteria,2JHSG@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
TLS2_k127_6111034_28	204669.Acid345_2147	8.791e-62	233.0	COG5495@1|root,COG5495@2|Bacteria,3Y57G@57723|Acidobacteria,2JJRB@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF2520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
TLS2_k127_6111034_29	1198114.AciX9_2649	3.85e-51	190.0	COG0494@1|root,COG0494@2|Bacteria,3Y4N9@57723|Acidobacteria,2JJ9X@204432|Acidobacteriia	204432|Acidobacteriia	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TLS2_k127_6111034_44	204669.Acid345_1523	7.229e-30	122.0	COG1278@1|root,COG1278@2|Bacteria,3Y57P@57723|Acidobacteria,2JJS8@204432|Acidobacteriia	204432|Acidobacteriia	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_6111034_1	204669.Acid345_2389	1.61e-263	826.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,3Y2SH@57723|Acidobacteria,2JHUE@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
TLS2_k127_6111034_40	204669.Acid345_2390	2.49e-31	134.0	2EEJ5@1|root,338D5@2|Bacteria,3Y5K7@57723|Acidobacteria,2JJX2@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6111034_45	621372.ACIH01000057_gene1188	1.094e-29	127.0	COG3764@1|root,COG3764@2|Bacteria,1V1RS@1239|Firmicutes,4HFWK@91061|Bacilli,26WRH@186822|Paenibacillaceae	91061|Bacilli	M	Sortase family	yhcS	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
TLS2_k127_6111034_56	298386.PBPRB1175	1.063e-13	74.0	2981C@1|root,2ZV7E@2|Bacteria,1QKN9@1224|Proteobacteria,1TISS@1236|Gammaproteobacteria,1XZKC@135623|Vibrionales	135623|Vibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6111034_33	670292.JH26_16595	5.275e-39	157.0	COG2230@1|root,COG2230@2|Bacteria,1R1FZ@1224|Proteobacteria,2TZ1A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	CMAS
TLS2_k127_6111034_35	1379698.RBG1_1C00001G0336	7.613e-36	145.0	COG5588@1|root,COG5588@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
TLS2_k127_6111034_6	1382359.JIAL01000001_gene2221	3.758e-220	707.0	COG0624@1|root,COG0624@2|Bacteria,3Y3TZ@57723|Acidobacteria,2JIUW@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_6111034_54	1037409.BJ6T_27460	1.577e-20	105.0	COG3801@1|root,COG3801@2|Bacteria,1REJV@1224|Proteobacteria,2U8BB@28211|Alphaproteobacteria,3JYZ9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
TLS2_k127_6111034_0	204669.Acid345_2638	0.0	1479.0	COG1196@1|root,COG1196@2|Bacteria,3Y2W1@57723|Acidobacteria,2JHJF@204432|Acidobacteriia	204432|Acidobacteriia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
TLS2_k127_6111034_14	1382359.JIAL01000001_gene2033	2.624e-134	434.0	COG0152@1|root,COG0152@2|Bacteria,3Y2KX@57723|Acidobacteria,2JIG6@204432|Acidobacteriia	204432|Acidobacteriia	F	SAICAR synthetase	purC	-	6.3.2.6,6.3.4.13	ko:K01923,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
TLS2_k127_6111034_31	204669.Acid345_2259	1.514e-46	174.0	COG1286@1|root,COG1286@2|Bacteria,3Y59W@57723|Acidobacteria,2JJP3@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Colicin V production	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
TLS2_k127_6111034_36	204669.Acid345_2260	4.559e-35	136.0	COG2204@1|root,COG2204@2|Bacteria,3Y98S@57723|Acidobacteria,2JP05@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8
TLS2_k127_6111034_32	1382359.JIAL01000001_gene2512	7.773e-44	177.0	COG2304@1|root,COG2304@2|Bacteria,3Y98T@57723|Acidobacteria,2JP5A@204432|Acidobacteriia	204432|Acidobacteriia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6111034_25	204669.Acid345_2262	5.126e-82	281.0	COG4221@1|root,COG4221@2|Bacteria,3Y4DX@57723|Acidobacteria,2JJ3I@204432|Acidobacteriia	204432|Acidobacteriia	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_6111034_52	240015.ACP_1069	4.804e-22	100.0	COG4980@1|root,COG4980@2|Bacteria,3Y5IA@57723|Acidobacteria,2JK01@204432|Acidobacteriia	204432|Acidobacteriia	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
TLS2_k127_6111034_43	204669.Acid345_2265	1.761e-30	127.0	2EFJQ@1|root,339C1@2|Bacteria,3Y5HX@57723|Acidobacteria,2JK17@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6111034_8	204669.Acid345_2270	2.108e-187	590.0	COG0482@1|root,COG0482@2|Bacteria,3Y2JX@57723|Acidobacteria,2JHKV@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TLS2_k127_6111034_12	204669.Acid345_2275	5.116e-167	532.0	COG1104@1|root,COG1104@2|Bacteria,3Y389@57723|Acidobacteria,2JIPA@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM aminotransferase class V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS2_k127_6111034_10	204669.Acid345_2276	1.076e-179	570.0	COG0372@1|root,COG0372@2|Bacteria,3Y32J@57723|Acidobacteria,2JII8@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS2_k127_6111034_23	861299.J421_5582	3.649e-85	291.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	bamU	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_6111034_48	655815.ZPR_1397	5.849e-28	124.0	COG2318@1|root,COG2318@2|Bacteria,4NNW4@976|Bacteroidetes,1I28C@117743|Flavobacteriia	976|Bacteroidetes	J	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_6111034_26	316057.RPD_1523	7.922e-73	258.0	COG1319@1|root,COG1319@2|Bacteria,1MVJS@1224|Proteobacteria,2TRAR@28211|Alphaproteobacteria,3JR53@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	MA20_09760	-	1.17.1.4,1.3.7.9	ko:K04109,ko:K11178	ko00230,ko00362,ko00627,ko01100,ko01120,ko01220,map00230,map00362,map00627,map01100,map01120,map01220	M00546	R01768,R02103,R05316	RC00143,RC00490	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_6111034_4	76114.ebA3603	7.878e-229	736.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,2KVZ2@206389|Rhodocyclales	206389|Rhodocyclales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	hcrA	-	1.3.7.9	ko:K04108	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_6111034_50	1122611.KB903941_gene2228	9.194e-25	106.0	COG2080@1|root,COG2080@2|Bacteria,2GMYH@201174|Actinobacteria,4EIUI@85012|Streptosporangiales	201174|Actinobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_6137431_1	1382359.JIAL01000001_gene462	0.0002443	51.0	28QZS@1|root,2ZDEJ@2|Bacteria,3Y4BV@57723|Acidobacteria,2JK72@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6137431_0	1382359.JIAL01000001_gene1831	5.075e-190	600.0	COG0379@1|root,COG0379@2|Bacteria,3Y328@57723|Acidobacteria,2JHY8@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
TLS2_k127_61445_5	204669.Acid345_2027	5.073e-137	441.0	COG0142@1|root,COG0142@2|Bacteria,3Y2VJ@57723|Acidobacteria,2JHS0@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_61445_13	204669.Acid345_2026	8.95e-59	209.0	COG1437@1|root,COG1437@2|Bacteria,3Y4V3@57723|Acidobacteria,2JJIG@204432|Acidobacteriia	204432|Acidobacteriia	F	CYTH	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
TLS2_k127_61445_6	234267.Acid_5939	5.182e-132	443.0	COG1807@1|root,COG1807@2|Bacteria,3Y383@57723|Acidobacteria	57723|Acidobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_61445_0	204669.Acid345_2855	0.0	1439.0	COG0653@1|root,COG0653@2|Bacteria,3Y34P@57723|Acidobacteria,2JHSP@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TLS2_k127_61445_15	204669.Acid345_2857	7.55e-45	170.0	COG3685@1|root,COG3685@2|Bacteria	2|Bacteria	S	cellular response to DNA damage stimulus	yciE	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	-	-	-	-	-	-	-	-	-	DUF892
TLS2_k127_61445_1	204669.Acid345_2858	0.0	1071.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,3Y3GW@57723|Acidobacteria,2JHKK@204432|Acidobacteriia	2|Bacteria	I	Phosphate acyltransferases	fadD	-	2.3.1.51,6.2.1.3	ko:K00655,ko:K01897	ko00061,ko00071,ko00561,ko00564,ko01100,ko01110,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00561,map00564,map01100,map01110,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086,M00089	R01280,R02241,R09381	RC00004,RC00014,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
TLS2_k127_61445_7	204669.Acid345_2860	5.28e-128	423.0	COG4974@1|root,COG4974@2|Bacteria,3Y2VX@57723|Acidobacteria,2JHNZ@204432|Acidobacteriia	204432|Acidobacteriia	L	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_61445_8	204669.Acid345_2861	1.095e-117	390.0	COG4974@1|root,COG4974@2|Bacteria,3Y3D0@57723|Acidobacteria,2JI2Q@204432|Acidobacteriia	204432|Acidobacteriia	L	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_61445_4	204669.Acid345_2863	7.895e-148	480.0	COG3285@1|root,COG3285@2|Bacteria,3Y637@57723|Acidobacteria,2JM9H@204432|Acidobacteriia	204432|Acidobacteriia	L	dna ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
TLS2_k127_61445_11	204669.Acid345_2864	3.796e-85	289.0	COG4914@1|root,COG4914@2|Bacteria,3Y7K0@57723|Acidobacteria,2JMQS@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_61445_9	204669.Acid345_2865	1.919e-104	343.0	COG2129@1|root,COG2129@2|Bacteria,3Y7PZ@57723|Acidobacteria,2JMV9@204432|Acidobacteriia	204432|Acidobacteriia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS2_k127_61445_10	204669.Acid345_1436	4.106e-94	326.0	COG0697@1|root,COG0697@2|Bacteria,3Y3CN@57723|Acidobacteria,2JHTE@204432|Acidobacteriia	204432|Acidobacteriia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_61445_14	166318.Syn8016DRAFT_1755	3.062e-47	182.0	COG3509@1|root,COG3509@2|Bacteria,1G723@1117|Cyanobacteria,1H3GV@1129|Synechococcus	1117|Cyanobacteria	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase_phd
TLS2_k127_61445_2	204669.Acid345_1435	1.676e-187	599.0	COG0265@1|root,COG0265@2|Bacteria,3Y2SD@57723|Acidobacteria,2JI16@204432|Acidobacteriia	204432|Acidobacteriia	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_61445_16	1382359.JIAL01000001_gene2063	9.769e-22	101.0	COG3409@1|root,COG3409@2|Bacteria,3Y5JQ@57723|Acidobacteria,2JJWV@204432|Acidobacteriia	204432|Acidobacteriia	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
TLS2_k127_61445_12	204669.Acid345_1275	3.523e-78	272.0	COG4464@1|root,COG4464@2|Bacteria,3Y4AS@57723|Acidobacteria,2JJ14@204432|Acidobacteriia	204432|Acidobacteriia	GM	protein tyrosine phosphatase activity	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
TLS2_k127_61445_3	682795.AciX8_3666	3.998e-183	578.0	COG0686@1|root,COG0686@2|Bacteria,3Y3Y9@57723|Acidobacteria,2JI1M@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TLS2_k127_6223966_0	204669.Acid345_0809	3.727e-257	812.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
TLS2_k127_6223966_1	234267.Acid_2875	4.084e-127	418.0	COG3844@1|root,COG3844@2|Bacteria,3Y984@57723|Acidobacteria	57723|Acidobacteria	F	Aminotransferase class-V	-	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
TLS2_k127_6223966_3	234267.Acid_3652	1.987e-17	94.0	COG1450@1|root,COG1450@2|Bacteria,3Y5BQ@57723|Acidobacteria	57723|Acidobacteria	NU	Type ii and iii secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6223966_2	204669.Acid345_0587	1.042e-34	139.0	COG1595@1|root,COG1595@2|Bacteria,3Y4E2@57723|Acidobacteria,2JJ2K@204432|Acidobacteriia	204432|Acidobacteriia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6360117_4	449447.MAE_61980	3.581e-13	74.0	COG1282@1|root,COG1282@2|Bacteria,1G2AX@1117|Cyanobacteria	1117|Cyanobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
TLS2_k127_6360117_3	864702.OsccyDRAFT_0322	2.931e-28	119.0	COG3288@1|root,COG3288@2|Bacteria,1G711@1117|Cyanobacteria,1HBSJ@1150|Oscillatoriales	1117|Cyanobacteria	C	NAD NADP transhydrogenase alpha subunit	pntA-2	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
TLS2_k127_6360117_1	861299.J421_0516	2.577e-133	436.0	COG3288@1|root,COG3288@2|Bacteria,1ZUJQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Alanine dehydrogenase/PNT, N-terminal domain	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TLS2_k127_6360117_0	251221.35210936	1.324e-148	507.0	COG1574@1|root,COG1574@2|Bacteria,1G40U@1117|Cyanobacteria	1117|Cyanobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_6360117_2	903814.ELI_4456	5.736e-40	163.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia,25UZ4@186806|Eubacteriaceae	186801|Clostridia	E	ABC transporter, substrate-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_6394052_0	1192034.CAP_4725	1.483e-66	252.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2X5YN@28221|Deltaproteobacteria,2YUEJ@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12
TLS2_k127_6394052_3	518766.Rmar_0987	0.0001875	53.0	COG0745@1|root,COG0745@2|Bacteria,4NIQC@976|Bacteroidetes,1FK2H@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_6394052_2	555779.Dthio_PD0364	2.176e-07	64.0	COG0457@1|root,COG0457@2|Bacteria,1N336@1224|Proteobacteria,42UTQ@68525|delta/epsilon subdivisions,2WQW8@28221|Deltaproteobacteria,2MCP0@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	SMART Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
TLS2_k127_6394052_1	243231.GSU1456	3.733e-57	216.0	COG0457@1|root,COG0457@2|Bacteria,1NU49@1224|Proteobacteria,42YQH@68525|delta/epsilon subdivisions,2WU55@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_643650_5	1267534.KB906754_gene3304	2.516e-48	177.0	COG0509@1|root,COG0509@2|Bacteria,3Y51Z@57723|Acidobacteria,2JJI2@204432|Acidobacteriia	204432|Acidobacteriia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
TLS2_k127_643650_1	204669.Acid345_2461	2.639e-169	539.0	COG0404@1|root,COG0404@2|Bacteria,3Y3IU@57723|Acidobacteria,2JI8G@204432|Acidobacteriia	204432|Acidobacteriia	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TLS2_k127_643650_6	204669.Acid345_2462	7.638e-34	133.0	COG0784@1|root,COG0784@2|Bacteria,3Y5K0@57723|Acidobacteria,2JJYE@204432|Acidobacteriia	204432|Acidobacteriia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_643650_4	290397.Adeh_1286	1.832e-57	214.0	COG0454@1|root,COG0456@2|Bacteria,1RD40@1224|Proteobacteria,43EF3@68525|delta/epsilon subdivisions,2X0ID@28221|Deltaproteobacteria,2Z1N2@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_643650_3	861299.J421_2228	2.27e-79	275.0	COG0702@1|root,COG0702@2|Bacteria,1ZV6Y@142182|Gemmatimonadetes	142182|Gemmatimonadetes	GM	NmrA-like family	-	-	1.6.5.2	ko:K19267	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
TLS2_k127_643650_7	331869.BAL199_23749	3.04e-31	126.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2U745@28211|Alphaproteobacteria,4BQAE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Response regulator receiver domain	divK	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
TLS2_k127_643650_2	247490.KSU1_C0316	4.907e-107	382.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,2J515@203682|Planctomycetes	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_3,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg
TLS2_k127_643650_0	204669.Acid345_1023	1.599e-236	749.0	COG1884@1|root,COG1884@2|Bacteria,3Y2QA@57723|Acidobacteria,2JKR7@204432|Acidobacteriia	204432|Acidobacteriia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS2_k127_6533229_11	518766.Rmar_2417	2.379e-41	155.0	COG3191@1|root,COG3191@2|Bacteria,4NGDT@976|Bacteroidetes,1FJRD@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
TLS2_k127_6533229_8	1340493.JNIF01000003_gene4460	3.44e-58	214.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
TLS2_k127_6533229_6	1379698.RBG1_1C00001G0370	1.715e-105	362.0	COG0616@1|root,COG0616@2|Bacteria,2NNKU@2323|unclassified Bacteria	2|Bacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TLS2_k127_6533229_1	118163.Ple7327_0161	8.34e-254	791.0	COG1012@1|root,COG1012@2|Bacteria,1G1BD@1117|Cyanobacteria,3VIAJ@52604|Pleurocapsales	1117|Cyanobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.39,1.2.1.79,1.2.1.8	ko:K00130,ko:K00135,ko:K00146,ko:K22187	ko00040,ko00250,ko00260,ko00310,ko00350,ko00360,ko00643,ko00650,ko00760,ko01100,ko01120,map00040,map00250,map00260,map00310,map00350,map00360,map00643,map00650,map00760,map01100,map01120	M00027,M00555	R00713,R00714,R02401,R02536,R02565,R02566,R11768	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_6533229_2	204669.Acid345_4380	4.68e-229	737.0	COG0457@1|root,COG2956@1|root,COG0457@2|Bacteria,COG2956@2|Bacteria,3Y89N@57723|Acidobacteria	57723|Acidobacteria	G	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
TLS2_k127_6533229_16	204669.Acid345_4379	7.86e-21	102.0	2DTVW@1|root,33MW2@2|Bacteria,3Y606@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6533229_13	204669.Acid345_2683	1.459e-37	159.0	COG3103@1|root,COG4991@2|Bacteria,3Y7ER@57723|Acidobacteria,2JM8Z@204432|Acidobacteriia	204432|Acidobacteriia	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6533229_4	1267534.KB906761_gene1214	4.975e-117	387.0	COG1611@1|root,COG1611@2|Bacteria,3Y2MR@57723|Acidobacteria,2JHUP@204432|Acidobacteriia	204432|Acidobacteriia	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TLS2_k127_6533229_0	204669.Acid345_2395	1.929e-282	885.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_16,TPR_2,TPR_8
TLS2_k127_6533229_10	714943.Mucpa_6984	3.135e-44	164.0	2C5VR@1|root,32CJG@2|Bacteria,4NQV8@976|Bacteroidetes,1ITMX@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6533229_9	204669.Acid345_4410	1.848e-52	192.0	COG0352@1|root,COG0352@2|Bacteria,3Y53Y@57723|Acidobacteria,2JJTS@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM thiamine monophosphate synthase	-	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TLS2_k127_6533229_15	351160.RCIX849	2.736e-22	102.0	COG4430@1|root,arCOG10241@2157|Archaea	351160.RCIX849|-	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6533229_5	1125973.JNLC01000001_gene141	1.036e-109	369.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2U0UY@28211|Alphaproteobacteria,3K361@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
TLS2_k127_6533229_14	204669.Acid345_4413	1.331e-24	107.0	COG1950@1|root,COG1950@2|Bacteria,3Y5FT@57723|Acidobacteria,2JJY4@204432|Acidobacteriia	204432|Acidobacteriia	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
TLS2_k127_6533229_3	861299.J421_1738	1.079e-126	420.0	COG0665@1|root,COG0665@2|Bacteria,1ZSZG@142182|Gemmatimonadetes	2|Bacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS2_k127_6533229_7	926550.CLDAP_13780	2.614e-92	318.0	COG2311@1|root,COG2311@2|Bacteria,2G8B7@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF418)	-	-	-	ko:K07148	-	-	-	-	ko00000	-	-	-	DUF418
TLS2_k127_6533229_17	1449353.JQMQ01000004_gene6491	1.849e-18	90.0	COG3467@1|root,COG3467@2|Bacteria,2I2V6@201174|Actinobacteria,2NIY9@228398|Streptacidiphilus	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
TLS2_k127_6533229_12	1382359.JIAL01000001_gene2615	6.655e-38	146.0	28JI8@1|root,2Z9BM@2|Bacteria,3Y535@57723|Acidobacteria,2JKHE@204432|Acidobacteriia	204432|Acidobacteriia	S	S1/P1 Nuclease	-	-	-	-	-	-	-	-	-	-	-	-	S1-P1_nuclease
TLS2_k127_6540656_0	1340493.JNIF01000003_gene3613	2.351e-162	538.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	ko:K02014,ko:K11031	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000,ko02042	1.B.14	-	-	Alginate_lyase2,CBM_6,CarbopepD_reg_2,F5_F8_type_C,Plug,Thiol_cytolys_C,Thiol_cytolysin,TonB_dep_Rec
TLS2_k127_6540656_2	189753.AXAS01000013_gene5867	2.808e-112	372.0	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,2TRQ1@28211|Alphaproteobacteria,3JSJF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
TLS2_k127_6540656_3	661478.OP10G_4211	3.182e-90	309.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS2_k127_6540656_6	926554.KI912680_gene783	3.453e-29	121.0	COG3603@1|root,COG3603@2|Bacteria,1WN1I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	COGs COG3603 conserved	-	-	-	ko:K09707	-	-	-	-	ko00000	-	-	-	ACT_7
TLS2_k127_6540656_8	768671.ThimaDRAFT_2369	9.042e-10	70.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1WWDN@135613|Chromatiales	135613|Chromatiales	S	PFAM Peptidoglycan-binding lysin domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
TLS2_k127_6540656_7	383372.Rcas_0886	9.905e-16	84.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_8,Response_reg
TLS2_k127_6540656_5	204669.Acid345_1365	8.318e-33	138.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	2.7.7.65	ko:K13590	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF,dCache_1
TLS2_k127_6540656_4	1396418.BATQ01000170_gene2658	3.172e-79	281.0	COG0745@1|root,COG1235@1|root,COG0745@2|Bacteria,COG1235@2|Bacteria,46UKB@74201|Verrucomicrobia,2IVU2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KT	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Response_reg
TLS2_k127_6540656_1	1125863.JAFN01000001_gene2904	3.885e-134	450.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	PFAM Type II secretion system protein E	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N,cNMP_binding
TLS2_k127_6550792_15	366649.XFF4834R_chr42170	4.189e-12	71.0	COG2931@1|root,COG3468@1|root,COG4625@1|root,COG2931@2|Bacteria,COG3468@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,1T45Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Domains in Na-Ca exchangers and integrin-beta4	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
TLS2_k127_6550792_14	1382359.JIAL01000001_gene1054	2.011e-13	83.0	2DBA2@1|root,2Z80Q@2|Bacteria,3Y2GC@57723|Acidobacteria,2JI5K@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TIG
TLS2_k127_6550792_1	204669.Acid345_2609	6.121e-235	747.0	COG3653@1|root,COG3653@2|Bacteria,3Y3Q2@57723|Acidobacteria,2JJ0K@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
TLS2_k127_6550792_10	240015.ACP_0983	2.464e-32	136.0	COG1836@1|root,COG1836@2|Bacteria,3Y537@57723|Acidobacteria,2JJM4@204432|Acidobacteriia	204432|Acidobacteriia	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
TLS2_k127_6550792_6	189753.AXAS01000021_gene1830	2.856e-41	170.0	COG3391@1|root,COG4625@1|root,COG3391@2|Bacteria,COG4625@2|Bacteria,1MU92@1224|Proteobacteria,2TSB7@28211|Alphaproteobacteria,3JUBZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Autotransporter beta-domain	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,PATR
TLS2_k127_6550792_0	204669.Acid345_1776	6.932e-301	957.0	COG2203@1|root,COG3829@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,RsbRD_N
TLS2_k127_6550792_8	204669.Acid345_1777	1.839e-38	151.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF,HATPase_c,HisKA,MASE1,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
TLS2_k127_6550792_2	204669.Acid345_1778	2.65e-199	632.0	COG2204@1|root,COG2204@2|Bacteria,3Y3HZ@57723|Acidobacteria,2JI47@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_6550792_9	204669.Acid345_1781	9.129e-33	137.0	COG0642@1|root,COG2205@2|Bacteria	204669.Acid345_1781|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6550792_5	756067.MicvaDRAFT_3990	2.46e-51	208.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1G26V@1117|Cyanobacteria,1H78U@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
TLS2_k127_6550792_11	316058.RPB_1250	1.154e-20	101.0	COG2197@1|root,COG2199@1|root,COG2197@2|Bacteria,COG3706@2|Bacteria,1MVNV@1224|Proteobacteria,2TTK7@28211|Alphaproteobacteria,3JVF1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	MA20_23080	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_6550792_4	1242864.D187_001731	9.142e-54	196.0	COG3428@1|root,COG3428@2|Bacteria	2|Bacteria	S	Bacterial PH domain	ydbT	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
TLS2_k127_6550792_7	1242864.D187_001730	2.256e-40	159.0	COG3428@1|root,COG3428@2|Bacteria	2|Bacteria	S	Bacterial PH domain	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	SHOCT,bPH_2
TLS2_k127_6550792_3	1408473.JHXO01000004_gene191	9.087e-56	199.0	COG2606@1|root,COG2606@2|Bacteria,4P3TW@976|Bacteroidetes,2FXVH@200643|Bacteroidia	976|Bacteroidetes	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
TLS2_k127_657069_10	1205753.A989_19553	4.516e-05	48.0	COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,1RNFM@1236|Gammaproteobacteria,1X3AP@135614|Xanthomonadales	135614|Xanthomonadales	S	Oxygen tolerance	-	-	-	-	-	-	-	-	-	-	-	-	BatD
TLS2_k127_657069_0	204669.Acid345_0596	7.845e-209	666.0	COG0497@1|root,COG0497@2|Bacteria,3Y2J4@57723|Acidobacteria,2JI9C@204432|Acidobacteriia	204432|Acidobacteriia	L	May be involved in recombinational repair of damaged DNA	-	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
TLS2_k127_657069_6	204669.Acid345_0595	3.471e-78	271.0	COG0811@1|root,COG0811@2|Bacteria,3Y2T8@57723|Acidobacteria,2JIN7@204432|Acidobacteriia	204432|Acidobacteriia	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
TLS2_k127_657069_8	204669.Acid345_0594	3.611e-52	191.0	COG0848@1|root,COG0848@2|Bacteria,3Y4QV@57723|Acidobacteria,2JJ9P@204432|Acidobacteriia	204432|Acidobacteriia	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS2_k127_657069_7	204669.Acid345_0593	1.082e-53	203.0	COG0810@1|root,COG0810@2|Bacteria,3Y4WH@57723|Acidobacteria,2JJSC@204432|Acidobacteriia	204432|Acidobacteriia	M	TonB C terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2
TLS2_k127_657069_1	204669.Acid345_0592	1.218e-184	589.0	COG0823@1|root,COG0823@2|Bacteria,3Y2RC@57723|Acidobacteria,2JIV3@204432|Acidobacteriia	204432|Acidobacteriia	U	WD40-like Beta Propeller	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
TLS2_k127_657069_5	204669.Acid345_0591	3.081e-82	280.0	COG2885@1|root,COG2885@2|Bacteria,3Y3ZY@57723|Acidobacteria,2JI9Y@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
TLS2_k127_657069_4	204669.Acid345_0590	1.843e-84	293.0	COG1729@1|root,COG1729@2|Bacteria,3Y3H6@57723|Acidobacteria,2JIES@204432|Acidobacteriia	204432|Acidobacteriia	S	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
TLS2_k127_657069_2	1267534.KB906754_gene3783	6.251e-173	549.0	COG1013@1|root,COG1013@2|Bacteria,3Y3NE@57723|Acidobacteria,2JIEM@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
TLS2_k127_657069_3	1267534.KB906754_gene3784	1.137e-114	372.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,3Y3NX@57723|Acidobacteria,2JKIA@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
TLS2_k127_6601852_1	861299.J421_5946	4.755e-317	1003.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1ZUMT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	QU	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
TLS2_k127_6601852_3	204669.Acid345_3209	3.089e-28	123.0	COG0745@1|root,COG0745@2|Bacteria,3Y4Z1@57723|Acidobacteria,2JJGX@204432|Acidobacteriia	204432|Acidobacteriia	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_6601852_4	378806.STAUR_2790	7.937e-07	54.0	2EFSR@1|root,339IR@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
TLS2_k127_6601852_0	926566.Terro_1684	0.0	1176.0	COG0587@1|root,COG0587@2|Bacteria,3Y3YK@57723|Acidobacteria,2JKQG@204432|Acidobacteriia	204432|Acidobacteriia	L	Belongs to the DNA polymerase type-C family. DnaE2 subfamily	-	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS2_k127_6601852_2	278963.ATWD01000001_gene2282	6.012e-38	154.0	COG0389@1|root,COG0389@2|Bacteria,3Y3EV@57723|Acidobacteria,2JIUC@204432|Acidobacteriia	204432|Acidobacteriia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	-	-	-	-	-	-	-	-	-	-	IMS
TLS2_k127_6611319_0	204669.Acid345_0080	2.292e-67	237.0	COG0445@1|root,COG0445@2|Bacteria,3Y3E4@57723|Acidobacteria,2JHP3@204432|Acidobacteriia	204432|Acidobacteriia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
TLS2_k127_6611319_3	240015.ACP_1840	6.017e-40	156.0	28K5J@1|root,2Z9U5@2|Bacteria,3Y2Y5@57723|Acidobacteria,2JHZR@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6611319_2	204669.Acid345_0042	2.69e-47	179.0	COG0357@1|root,COG0357@2|Bacteria,3Y4W7@57723|Acidobacteria,2JJG7@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
TLS2_k127_6611319_1	1166018.FAES_3793	8.211e-52	197.0	COG2318@1|root,COG2318@2|Bacteria,4NN7V@976|Bacteroidetes,47QXV@768503|Cytophagia	976|Bacteroidetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
TLS2_k127_6618054_17	204669.Acid345_0136	2.667e-42	157.0	COG1521@1|root,COG1521@2|Bacteria,3Y398@57723|Acidobacteria,2JI76@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
TLS2_k127_6618054_10	204669.Acid345_0137	1.838e-68	248.0	COG3468@1|root,COG3468@2|Bacteria,3Y4NE@57723|Acidobacteria,2JJBC@204432|Acidobacteriia	204432|Acidobacteriia	MU	outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6618054_4	204669.Acid345_0138	4.314e-141	461.0	COG2265@1|root,COG2265@2|Bacteria,3Y3SF@57723|Acidobacteria,2JI9H@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
TLS2_k127_6618054_0	204669.Acid345_0140	1.276e-201	658.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,3Y3VQ@57723|Acidobacteria,2JI41@204432|Acidobacteriia	204432|Acidobacteriia	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
TLS2_k127_6618054_22	1382359.JIAL01000001_gene2676	4.05e-26	112.0	2EA3B@1|root,3348D@2|Bacteria,3Y5J1@57723|Acidobacteria,2JJZE@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6618054_12	204669.Acid345_4722	3.516e-61	220.0	COG2020@1|root,COG2020@2|Bacteria,3Y4P4@57723|Acidobacteria,2JJJZ@204432|Acidobacteriia	204432|Acidobacteriia	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TLS2_k127_6618054_6	204669.Acid345_4721	4.187e-95	323.0	COG0859@1|root,COG0859@2|Bacteria,3Y3EJ@57723|Acidobacteria,2JIYJ@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM glycosyl transferase family 9	-	-	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TLS2_k127_6618054_15	1144275.COCOR_02686	1.878e-44	175.0	COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,42SGQ@68525|delta/epsilon subdivisions,2WPTP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	rfaE	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
TLS2_k127_6618054_11	1047013.AQSP01000111_gene1672	8.279e-68	254.0	COG2870@1|root,COG2870@2|Bacteria,2NNUT@2323|unclassified Bacteria	2|Bacteria	M	pfkB family carbohydrate kinase	rfaE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
TLS2_k127_6618054_9	204669.Acid345_4719	5.225e-86	306.0	COG1663@1|root,COG1663@2|Bacteria,3Y5FQ@57723|Acidobacteria,2JJ24@204432|Acidobacteriia	204432|Acidobacteriia	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
TLS2_k127_6618054_3	204669.Acid345_4718	6.688e-144	468.0	COG1519@1|root,COG1519@2|Bacteria,3Y3X5@57723|Acidobacteria,2JI61@204432|Acidobacteriia	204432|Acidobacteriia	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
TLS2_k127_6618054_19	204669.Acid345_4717	1.162e-36	147.0	2B707@1|root,3200P@2|Bacteria,3Y4XV@57723|Acidobacteria,2JJG8@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6618054_1	644282.Deba_0849	1.307e-170	556.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
TLS2_k127_6618054_24	1408473.JHXO01000005_gene1607	9.805e-20	98.0	28RK7@1|root,2ZDZ1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6618054_14	204669.Acid345_4105	6.447e-47	171.0	COG0776@1|root,COG0776@2|Bacteria,3Y56V@57723|Acidobacteria,2JJMF@204432|Acidobacteriia	204432|Acidobacteriia	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_6618054_26	1470591.BW41_02916	4.79e-06	55.0	COG2717@1|root,COG2717@2|Bacteria,1R4CY@1224|Proteobacteria,2U37R@28211|Alphaproteobacteria,2K8AU@204457|Sphingomonadales	204457|Sphingomonadales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6618054_21	251221.35213956	5.988e-31	132.0	COG4798@1|root,COG4798@2|Bacteria,1GQ94@1117|Cyanobacteria	1117|Cyanobacteria	S	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
TLS2_k127_6618054_20	1382359.JIAL01000001_gene1403	3.38e-35	143.0	COG0261@1|root,COG0261@2|Bacteria,3Y561@57723|Acidobacteria,2JJSM@204432|Acidobacteriia	204432|Acidobacteriia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
TLS2_k127_6618054_18	1267533.KB906741_gene415	3.66e-41	153.0	COG0211@1|root,COG0211@2|Bacteria,3Y5D8@57723|Acidobacteria,2JJPG@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
TLS2_k127_6618054_2	1382359.JIAL01000001_gene654	8.815e-166	527.0	COG0536@1|root,COG0536@2|Bacteria,3Y2J7@57723|Acidobacteria,2JI5G@204432|Acidobacteriia	204432|Acidobacteriia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
TLS2_k127_6618054_13	204669.Acid345_0021	5.113e-57	209.0	COG1057@1|root,COG1057@2|Bacteria,3Y5D2@57723|Acidobacteria,2JJNT@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_6618054_16	204669.Acid345_0022	4.883e-44	166.0	COG0799@1|root,COG0799@2|Bacteria,3Y5SD@57723|Acidobacteria,2JJ9Z@204432|Acidobacteriia	204432|Acidobacteriia	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
TLS2_k127_6618054_5	204669.Acid345_0023	4.998e-119	396.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria,2JICQ@204432|Acidobacteriia	57723|Acidobacteria	T	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
TLS2_k127_6618054_8	204669.Acid345_3085	1.323e-86	295.0	COG0810@1|root,COG0810@2|Bacteria,3Y4BU@57723|Acidobacteria,2JJ3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
TLS2_k127_6618054_23	1382359.JIAL01000001_gene2177	4.069e-25	119.0	298E3@1|root,2ZVJA@2|Bacteria,3Y4NI@57723|Acidobacteria,2JJAV@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6618054_7	861299.J421_1756	5.143e-94	320.0	COG0624@1|root,COG0624@2|Bacteria,1ZUA4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_6634842_0	204669.Acid345_2542	7.775e-170	541.0	COG0126@1|root,COG0126@2|Bacteria,3Y2T7@57723|Acidobacteria,2JI0Z@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
TLS2_k127_6634842_1	1382359.JIAL01000001_gene207	1.549e-162	517.0	COG0057@1|root,COG0057@2|Bacteria,3Y2QC@57723|Acidobacteria,2JI8H@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TLS2_k127_6634842_2	1267534.KB906756_gene304	1.837e-67	245.0	COG4639@1|root,COG4639@2|Bacteria,3Y3YS@57723|Acidobacteria,2JI4H@204432|Acidobacteriia	204432|Acidobacteriia	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
TLS2_k127_6648595_20	1168065.DOK_09024	7.974e-10	59.0	COG3011@1|root,COG3011@2|Bacteria,1N0YV@1224|Proteobacteria,1TAMZ@1236|Gammaproteobacteria,1JBCM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
TLS2_k127_6648595_17	240015.ACP_1095	4.744e-60	211.0	COG2001@1|root,COG2001@2|Bacteria,3Y4NF@57723|Acidobacteria,2JJA0@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
TLS2_k127_6648595_12	204669.Acid345_3638	3.059e-115	379.0	COG0275@1|root,COG0275@2|Bacteria,3Y31S@57723|Acidobacteria,2JHM1@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
TLS2_k127_6648595_18	204669.Acid345_3636	1.661e-36	143.0	COG2919@1|root,COG2919@2|Bacteria,3Y4JZ@57723|Acidobacteria,2JJBJ@204432|Acidobacteriia	204432|Acidobacteriia	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	-	-	-	-	-	-	-	-	-	-	-	-	DivIC,FtsL
TLS2_k127_6648595_0	204669.Acid345_3635	3.683e-229	731.0	COG0768@1|root,COG0768@2|Bacteria,3Y2XX@57723|Acidobacteria,2JHPS@204432|Acidobacteriia	204432|Acidobacteriia	M	Penicillin-binding protein, dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
TLS2_k127_6648595_1	204669.Acid345_3634	9.105e-206	651.0	COG0769@1|root,COG0769@2|Bacteria,3Y38W@57723|Acidobacteria,2JJ0C@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_6648595_5	204669.Acid345_3633	1.906e-180	580.0	COG0770@1|root,COG0770@2|Bacteria,3Y3I2@57723|Acidobacteria,2JHW4@204432|Acidobacteriia	204432|Acidobacteriia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_6648595_4	204669.Acid345_3632	1.582e-185	586.0	COG0472@1|root,COG0472@2|Bacteria,3Y2ZH@57723|Acidobacteria,2JIGX@204432|Acidobacteriia	204432|Acidobacteriia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
TLS2_k127_6648595_3	204669.Acid345_3631	8.036e-187	595.0	COG0771@1|root,COG0771@2|Bacteria,3Y2JK@57723|Acidobacteria,2JHQF@204432|Acidobacteriia	204432|Acidobacteriia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_6648595_8	204669.Acid345_3630	9.199e-142	461.0	COG0772@1|root,COG0772@2|Bacteria,3Y330@57723|Acidobacteria,2JHW0@204432|Acidobacteriia	204432|Acidobacteriia	D	Belongs to the SEDS family	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
TLS2_k127_6648595_9	204669.Acid345_3629	1.733e-132	432.0	COG0707@1|root,COG0707@2|Bacteria,3Y48B@57723|Acidobacteria,2JIYA@204432|Acidobacteriia	204432|Acidobacteriia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
TLS2_k127_6648595_19	1123399.AQVE01000001_gene736	1.368e-29	128.0	2DQHJ@1|root,336X1@2|Bacteria,1QYDU@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6648595_2	204669.Acid345_3628	6.393e-201	635.0	COG0773@1|root,COG0773@2|Bacteria,3Y304@57723|Acidobacteria,2JIHZ@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_6648595_15	234267.Acid_5560	1.315e-74	264.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC5,TPR_15,TPR_16,TPR_4,TPR_8
TLS2_k127_6648595_14	204669.Acid345_3453	5.279e-101	339.0	COG1589@1|root,COG1589@2|Bacteria,3Y3BQ@57723|Acidobacteria,2JIZS@204432|Acidobacteriia	204432|Acidobacteriia	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
TLS2_k127_6648595_11	1382359.JIAL01000001_gene555	9.395e-130	430.0	COG0849@1|root,COG0849@2|Bacteria,3Y432@57723|Acidobacteria,2JI1Q@204432|Acidobacteriia	204432|Acidobacteriia	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
TLS2_k127_6648595_6	204669.Acid345_3451	1.44e-179	571.0	COG0206@1|root,COG0206@2|Bacteria,3Y2WG@57723|Acidobacteria,2JHRJ@204432|Acidobacteriia	204432|Acidobacteriia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS2_k127_6648595_10	204669.Acid345_3450	4.825e-130	426.0	COG0768@1|root,COG0768@2|Bacteria,3Y3EP@57723|Acidobacteria,2JI45@204432|Acidobacteriia	204432|Acidobacteriia	M	penicillin-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Transpeptidase
TLS2_k127_6648595_16	1267534.KB906754_gene3390	1.744e-63	243.0	COG2202@1|root,COG3829@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,3Y6VM@57723|Acidobacteria,2JKH6@204432|Acidobacteriia	204432|Acidobacteriia	T	PAS PAC sensor signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
TLS2_k127_6648595_13	204669.Acid345_3324	5.955e-110	372.0	COG1136@1|root,COG1136@2|Bacteria,3Y30Q@57723|Acidobacteria,2JI7R@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6648595_7	204669.Acid345_3323	1.232e-151	493.0	COG0845@1|root,COG0845@2|Bacteria,3Y2XR@57723|Acidobacteria,2JHTV@204432|Acidobacteriia	204432|Acidobacteriia	M	Efflux transporter, RND family, MFP subunit	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
TLS2_k127_6691687_21	1123023.JIAI01000002_gene4958	2.059e-36	145.0	COG1335@1|root,COG1335@2|Bacteria,2I284@201174|Actinobacteria,4E42Y@85010|Pseudonocardiales	201174|Actinobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS2_k127_6691687_10	1123024.AUII01000001_gene3122	6.587e-97	338.0	COG1574@1|root,COG1574@2|Bacteria,2IA0K@201174|Actinobacteria	201174|Actinobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_6691687_9	1408428.JNJP01000081_gene1801	3.995e-105	358.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42NQT@68525|delta/epsilon subdivisions,2WJKD@28221|Deltaproteobacteria,2MHEP@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
TLS2_k127_6691687_15	1157635.KB892013_gene2160	3.114e-66	245.0	COG1402@1|root,COG1402@2|Bacteria,2IK6F@201174|Actinobacteria	201174|Actinobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
TLS2_k127_6691687_20	1111069.TCCBUS3UF1_13090	2.789e-37	155.0	COG0599@1|root,COG0599@2|Bacteria,1WK2N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_6691687_23	1220589.CD32_10685	8.344e-12	67.0	COG1942@1|root,COG1942@2|Bacteria,1VJK6@1239|Firmicutes,4HPKD@91061|Bacilli,3IYX8@400634|Lysinibacillus	91061|Bacilli	G	Belongs to the 4-oxalocrotonate tautomerase family	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
TLS2_k127_6691687_19	1345697.M493_17910	3.433e-47	190.0	COG3971@1|root,COG3971@2|Bacteria,1UYC8@1239|Firmicutes,4HB58@91061|Bacilli,1WGAI@129337|Geobacillus	91061|Bacilli	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	4.1.1.77	ko:K01617	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R02602,R05374	RC00751,RC02672	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
TLS2_k127_6691687_6	1034347.CAHJ01000012_gene2355	4.109e-133	432.0	COG0119@1|root,COG0119@2|Bacteria,1TS0A@1239|Firmicutes,4HAXZ@91061|Bacilli,1ZARP@1386|Bacillus	91061|Bacilli	E	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds	dmpG	-	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	DmpG_comm,HMGL-like
TLS2_k127_6691687_7	1234664.AMRO01000077_gene3348	7.592e-110	363.0	COG4569@1|root,COG4569@2|Bacteria,1TQJS@1239|Firmicutes,4HCRZ@91061|Bacilli,1WG8K@129337|Geobacillus	91061|Bacilli	Q	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds	mhpF	-	1.2.1.10	ko:K04073	ko00360,ko00362,ko00620,ko00621,ko00622,ko00650,ko01100,ko01120,ko01220,map00360,map00362,map00620,map00621,map00622,map00650,map01100,map01120,map01220	M00545,M00569	R00228,R01172	RC00004,RC00184,RC01195	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	AcetDehyd-dimer,Semialdhyde_dh
TLS2_k127_6691687_14	1123024.AUII01000005_gene2417	5.272e-67	249.0	COG3971@1|root,COG3971@2|Bacteria,2GPBI@201174|Actinobacteria,4DZKH@85010|Pseudonocardiales	201174|Actinobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	4.2.1.80	ko:K02554	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R02601,R04781	RC00750,RC01213	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
TLS2_k127_6691687_16	340099.Teth39_1975	5.618e-64	231.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,42G3H@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulator IclR	-	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
TLS2_k127_6691687_0	1267535.KB906767_gene942	5.825e-193	642.0	COG1629@1|root,COG4771@2|Bacteria,3Y2ZK@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_6691687_1	1038860.AXAP01000146_gene3834	5.105e-185	597.0	COG0252@1|root,COG0252@2|Bacteria,1R4S1@1224|Proteobacteria	1224|Proteobacteria	EJ	Asparaginase	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase
TLS2_k127_6691687_2	333138.LQ50_18175	6.257e-177	567.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,1ZAY9@1386|Bacillus	91061|Bacilli	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.32,1.2.1.85	ko:K10217	ko00362,ko00380,ko00622,ko01100,ko01120,ko01220,map00362,map00380,map00622,map01100,map01120,map01220	M00038,M00569	R02762,R03889,R05353	RC00218,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_6691687_22	1231391.AMZF01000014_gene2400	4.503e-26	111.0	2EPW1@1|root,33HGJ@2|Bacteria,1P260@1224|Proteobacteria	1224|Proteobacteria	S	Aromatic-ring-opening dioxygenase LigAB, LigA subunit	-	-	-	-	-	-	-	-	-	-	-	-	LigA
TLS2_k127_6691687_18	1157635.KB892013_gene2150	7.507e-59	214.0	COG1335@1|root,COG1335@2|Bacteria	2|Bacteria	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	-	-	3.5.1.110,3.5.1.19	ko:K08281,ko:K09020	ko00240,ko00760,ko01100,map00240,map00760,map01100	-	R01268,R09947,R09980	RC00100,RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
TLS2_k127_6691687_11	1231391.AMZF01000014_gene2399	6.672e-86	292.0	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VTUV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	1.13.11.8	ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigB
TLS2_k127_6691687_12	1267533.KB906734_gene3706	9.693e-78	268.0	COG1028@1|root,COG1028@2|Bacteria,3Y4CZ@57723|Acidobacteria,2JMNQ@204432|Acidobacteriia	204432|Acidobacteriia	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_6691687_3	204669.Acid345_1531	5.625e-175	561.0	COG1012@1|root,COG1012@2|Bacteria,3Y3Z0@57723|Acidobacteria,2JI2S@204432|Acidobacteriia	204432|Acidobacteriia	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_6691687_8	479434.Sthe_1513	1.925e-105	365.0	COG1574@1|root,COG1574@2|Bacteria,2G5YJ@200795|Chloroflexi,27YYI@189775|Thermomicrobia	189775|Thermomicrobia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_6691687_4	566466.NOR53_670	1.004e-156	512.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1J7SK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_6691687_13	1122222.AXWR01000040_gene649	1.972e-70	256.0	COG3191@1|root,COG3191@2|Bacteria,1WJKZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EQ	PFAM peptidase S58 DmpA	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
TLS2_k127_6691687_17	204669.Acid345_1539	2.157e-63	226.0	COG0789@1|root,COG1396@1|root,COG1917@1|root,COG0789@2|Bacteria,COG1396@2|Bacteria,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	Cupin_2,HTH_3,HTH_31,MerR_1
TLS2_k127_6691687_5	234267.Acid_7606	8.585e-139	482.0	COG1629@1|root,COG4771@2|Bacteria,3Y3YV@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6723089_14	204669.Acid345_3224	4.392e-14	76.0	COG0006@1|root,COG0006@2|Bacteria,3Y36W@57723|Acidobacteria,2JI54@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the peptidase M24B family	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
TLS2_k127_6723089_2	204669.Acid345_2904	8.466e-256	797.0	COG1215@1|root,COG1215@2|Bacteria,3Y31I@57723|Acidobacteria,2JIKW@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
TLS2_k127_6723089_4	204669.Acid345_2881	9.233e-193	604.0	COG1060@1|root,COG1060@2|Bacteria,3Y2IA@57723|Acidobacteria,2JIBR@204432|Acidobacteriia	204432|Acidobacteriia	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
TLS2_k127_6723089_12	1449076.JOOE01000001_gene2608	1.125e-24	111.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	ble	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_6723089_15	582899.Hden_1897	7.855e-07	53.0	2EUJ6@1|root,331Z2@2|Bacteria,1NBW9@1224|Proteobacteria,2UFCT@28211|Alphaproteobacteria,3N9BU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6723089_9	338966.Ppro_3257	7.515e-54	211.0	COG1808@1|root,COG1808@2|Bacteria,1NMS3@1224|Proteobacteria,42PXT@68525|delta/epsilon subdivisions,2WR2Y@28221|Deltaproteobacteria,43T2J@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
TLS2_k127_6723089_13	401053.AciPR4_3126	1.465e-23	108.0	COG0586@1|root,COG0586@2|Bacteria,3Y4JN@57723|Acidobacteria,2JJ9B@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_6723089_8	204669.Acid345_3342	1.59e-81	279.0	COG1427@1|root,COG1427@2|Bacteria,3Y3PU@57723|Acidobacteria,2JIWB@204432|Acidobacteriia	204432|Acidobacteriia	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
TLS2_k127_6723089_5	204669.Acid345_3341	3.172e-152	491.0	COG0322@1|root,COG0758@1|root,COG0322@2|Bacteria,COG0758@2|Bacteria,3Y42M@57723|Acidobacteria,2JI6N@204432|Acidobacteriia	204432|Acidobacteriia	LU	DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
TLS2_k127_6723089_11	489825.LYNGBM3L_21480	4.574e-33	133.0	2DNS7@1|root,32YWC@2|Bacteria,1G8QD@1117|Cyanobacteria,1HGCH@1150|Oscillatoriales	1117|Cyanobacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
TLS2_k127_6723089_1	204669.Acid345_3340	0.0	1282.0	COG0550@1|root,COG0550@2|Bacteria,3Y343@57723|Acidobacteria,2JHPW@204432|Acidobacteriia	204432|Acidobacteriia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
TLS2_k127_6723089_7	1382359.JIAL01000001_gene2413	1.121e-106	356.0	COG1127@1|root,COG1127@2|Bacteria,3Y3YI@57723|Acidobacteria,2JIF1@204432|Acidobacteriia	204432|Acidobacteriia	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TLS2_k127_6723089_6	204669.Acid345_2890	3.329e-110	365.0	COG0767@1|root,COG0767@2|Bacteria,3Y43S@57723|Acidobacteria,2JI8E@204432|Acidobacteriia	204432|Acidobacteriia	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
TLS2_k127_6723089_3	240015.ACP_0180	2.382e-213	671.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria,2JIG9@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_6723089_0	204669.Acid345_3357	0.0	1283.0	COG4191@1|root,COG4191@2|Bacteria,3Y3X4@57723|Acidobacteria,2JING@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,HisKA_7TM,PAS,PAS_4
TLS2_k127_6723089_10	1131730.BAVI_02154	2.667e-40	158.0	2E9KM@1|root,333TD@2|Bacteria,1VW4V@1239|Firmicutes,4HWQP@91061|Bacilli,1ZGRR@1386|Bacillus	91061|Bacilli	S	Immunity protein 26	-	-	-	-	-	-	-	-	-	-	-	-	Imm26
TLS2_k127_6723089_16	682795.AciX8_0207	2.178e-06	49.0	COG4775@1|root,COG4775@2|Bacteria,3Y2Q9@57723|Acidobacteria,2JHYD@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM outer membrane protein assembly complex, YaeT protein	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TLS2_k127_672830_7	234267.Acid_1757	7.279e-32	134.0	COG0789@1|root,COG0789@2|Bacteria,3Y5XK@57723|Acidobacteria	57723|Acidobacteria	K	MerR, DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind
TLS2_k127_672830_6	204669.Acid345_0986	3.341e-35	140.0	COG3245@1|root,COG3245@2|Bacteria,3Y5B1@57723|Acidobacteria,2JN9F@204432|Acidobacteriia	204432|Acidobacteriia	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_672830_4	204669.Acid345_2302	1.077e-66	252.0	COG0755@1|root,COG0755@2|Bacteria,3Y4FE@57723|Acidobacteria,2JJ1X@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM Cytochrome c assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
TLS2_k127_672830_2	204669.Acid345_2303	1.432e-90	304.0	COG2386@1|root,COG2386@2|Bacteria,3Y3G1@57723|Acidobacteria,2JIEJ@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM Cytochrome c-type biogenesis protein CcmB	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
TLS2_k127_672830_3	204669.Acid345_2304	1.688e-68	242.0	COG1131@1|root,COG1131@2|Bacteria,3Y4M9@57723|Acidobacteria,2JJD2@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_672830_5	1267534.KB906755_gene4550	6.018e-41	156.0	COG2332@1|root,COG2332@2|Bacteria,3Y57C@57723|Acidobacteria,2JJR8@204432|Acidobacteriia	204432|Acidobacteriia	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
TLS2_k127_672830_8	1121920.AUAU01000004_gene904	1.324e-11	78.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,MFS_1,TLC,cNMP_binding
TLS2_k127_672830_1	204669.Acid345_2307	1.919e-270	841.0	COG0422@1|root,COG0422@2|Bacteria,3Y2TX@57723|Acidobacteria,2JHMC@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
TLS2_k127_672830_0	1382359.JIAL01000001_gene2098	1.919e-284	895.0	COG0531@1|root,COG0531@2|Bacteria,3Y2RG@57723|Acidobacteria,2JHMH@204432|Acidobacteriia	204432|Acidobacteriia	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
TLS2_k127_6757211_0	204669.Acid345_2976	1.262e-27	121.0	COG0704@1|root,COG0704@2|Bacteria	2|Bacteria	P	negative regulation of phosphate transmembrane transport	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TLS2_k127_6757211_1	28377.ENSACAP00000007709	1.292e-14	83.0	COG0666@1|root,KOG4177@2759|Eukaryota,38EUY@33154|Opisthokonta,3BAA9@33208|Metazoa,3CRYK@33213|Bilateria,487T5@7711|Chordata,48VVI@7742|Vertebrata	33208|Metazoa	M	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	TNKS2	GO:0000209,GO:0000228,GO:0000242,GO:0000723,GO:0000781,GO:0000784,GO:0003674,GO:0003824,GO:0003950,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005694,GO:0005737,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0006139,GO:0006259,GO:0006464,GO:0006471,GO:0006725,GO:0006807,GO:0006996,GO:0008104,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009966,GO:0009967,GO:0009987,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010638,GO:0010639,GO:0010646,GO:0010647,GO:0012505,GO:0015630,GO:0016043,GO:0016567,GO:0016740,GO:0016757,GO:0016763,GO:0019219,GO:0019222,GO:0019538,GO:0019899,GO:0023051,GO:0023056,GO:0030111,GO:0030162,GO:0030177,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031331,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032200,GO:0032204,GO:0032205,GO:0032206,GO:0032210,GO:0032212,GO:0032268,GO:0032270,GO:0032446,GO:0032501,GO:0032502,GO:0033036,GO:0033043,GO:0033044,GO:0033365,GO:0034502,GO:0034613,GO:0034641,GO:0035264,GO:0036211,GO:0040007,GO:0040008,GO:0040014,GO:0042176,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043412,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044450,GO:0044454,GO:0044464,GO:0045732,GO:0045862,GO:0045934,GO:0045935,GO:0046483,GO:0048471,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048589,GO:0048638,GO:0050789,GO:0050793,GO:0050794,GO:0051052,GO:0051053,GO:0051054,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051179,GO:0051239,GO:0051246,GO:0051247,GO:0051276,GO:0051641,GO:0060249,GO:0060255,GO:0060828,GO:0065007,GO:0065008,GO:0070013,GO:0070198,GO:0070212,GO:0070213,GO:0070647,GO:0070727,GO:0071704,GO:0071840,GO:0080090,GO:0090263,GO:0090304,GO:0090364,GO:0097110,GO:0098687,GO:1901360,GO:1901564,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1904353,GO:1904355,GO:1904356,GO:1904357,GO:1904358,GO:2000058,GO:2000060,GO:2000112,GO:2000278,GO:2000573,GO:2001251,GO:2001252	2.4.2.30	ko:K10799	-	-	-	-	ko00000,ko01000,ko03032,ko03036	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,PARP,SAM_2
TLS2_k127_6757211_2	1382359.JIAL01000001_gene2326	1.536e-07	53.0	COG5002@1|root,COG5002@2|Bacteria,3Y3AX@57723|Acidobacteria,2JI3A@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_7
TLS2_k127_6767649_3	204669.Acid345_4564	9.871e-105	352.0	COG1472@1|root,COG1472@2|Bacteria,3Y6UR@57723|Acidobacteria,2JM9X@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
TLS2_k127_6767649_6	243231.GSU0568	7.696e-16	82.0	2AFDJ@1|root,315DD@2|Bacteria,1PVF9@1224|Proteobacteria,436DH@68525|delta/epsilon subdivisions,2XA0V@28221|Deltaproteobacteria,43VKE@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6767649_2	1198114.AciX9_1936	6.402e-159	529.0	COG2091@1|root,COG2091@2|Bacteria,3Y46J@57723|Acidobacteria,2JHWP@204432|Acidobacteriia	204432|Acidobacteriia	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6767649_1	204669.Acid345_4544	3.112e-175	555.0	COG2255@1|root,COG2255@2|Bacteria,3Y2RP@57723|Acidobacteria,2JIMW@204432|Acidobacteriia	204432|Acidobacteriia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
TLS2_k127_6767649_5	930169.B5T_03379	1.031e-18	90.0	COG1734@1|root,COG1734@2|Bacteria,1N7D8@1224|Proteobacteria,1SCG1@1236|Gammaproteobacteria,1XM1K@135619|Oceanospirillales	135619|Oceanospirillales	T	COG1734 DnaK suppressor protein	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
TLS2_k127_6767649_0	555088.DealDRAFT_2165	4.681e-215	689.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia,42JHA@68298|Syntrophomonadaceae	186801|Clostridia	J	elongation factor Tu domain 2 protein	fusA2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_6767649_4	932678.THERU_02135	5.207e-40	156.0	COG2346@1|root,COG2346@2|Bacteria,2G5AF@200783|Aquificae	200783|Aquificae	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
TLS2_k127_6767649_7	204669.Acid345_4117	5.46e-06	48.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
TLS2_k127_6799790_12	1382359.JIAL01000001_gene870	7.07e-10	74.0	COG3055@1|root,COG3055@2|Bacteria,3Y93M@57723|Acidobacteria	2|Bacteria	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF5060,PPC,Peptidase_S8,Reprolysin_5,VPEP
TLS2_k127_6799790_10	357808.RoseRS_1250	1.047e-18	103.0	COG3391@1|root,COG4935@1|root,COG3391@2|Bacteria,COG4935@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	DUF11,P_proprotein,VCBS
TLS2_k127_6799790_4	1123368.AUIS01000011_gene1139	5.991e-134	480.0	COG1404@1|root,COG1404@2|Bacteria,1R90Q@1224|Proteobacteria,1S01H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
TLS2_k127_6799790_0	1382359.JIAL01000001_gene1105	1.26e-176	561.0	COG0183@1|root,COG0183@2|Bacteria,3Y3SQ@57723|Acidobacteria,2JHU2@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_6799790_5	204669.Acid345_3241	4.99e-77	265.0	COG1385@1|root,COG1385@2|Bacteria,3Y3XJ@57723|Acidobacteria,2JI6A@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
TLS2_k127_6799790_1	926566.Terro_2690	2.189e-138	449.0	COG0484@1|root,COG0484@2|Bacteria,3Y33I@57723|Acidobacteria,2JIBF@204432|Acidobacteriia	204432|Acidobacteriia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_6799790_7	204669.Acid345_3243	9.271e-41	170.0	COG0576@1|root,COG0576@2|Bacteria,3Y54K@57723|Acidobacteria,2JJMY@204432|Acidobacteriia	204432|Acidobacteriia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS2_k127_6799790_3	204669.Acid345_3244	2.661e-136	443.0	COG1420@1|root,COG1420@2|Bacteria,3Y2JI@57723|Acidobacteria,2JI0D@204432|Acidobacteriia	204432|Acidobacteriia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
TLS2_k127_6799790_2	204669.Acid345_3248	8.705e-137	440.0	COG0489@1|root,COG0489@2|Bacteria,3Y38H@57723|Acidobacteria,2JIAF@204432|Acidobacteriia	204432|Acidobacteriia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
TLS2_k127_6799790_6	204669.Acid345_3253	1.501e-64	230.0	COG1607@1|root,COG1607@2|Bacteria,3Y53T@57723|Acidobacteria,2JMAX@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_6799790_11	234267.Acid_0134	2.041e-14	78.0	295WJ@1|root,2ZT7G@2|Bacteria,3Y8RM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6799790_9	1267533.KB906733_gene3307	1.232e-31	128.0	COG4783@1|root,COG4783@2|Bacteria,3Y5FY@57723|Acidobacteria,2JJX1@204432|Acidobacteriia	204432|Acidobacteriia	S	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	TPR_17,TPR_19
TLS2_k127_6799790_8	204669.Acid345_3255	3.726e-40	154.0	COG0300@1|root,COG0300@2|Bacteria,3Y5F6@57723|Acidobacteria,2JNN8@204432|Acidobacteriia	204432|Acidobacteriia	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_680315_8	1382359.JIAL01000001_gene938	5.207e-37	144.0	COG0438@1|root,COG0438@2|Bacteria,3Y6T4@57723|Acidobacteria,2JMK3@204432|Acidobacteriia	204432|Acidobacteriia	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glycos_transf_1
TLS2_k127_680315_7	313612.L8106_06329	1.351e-47	179.0	COG0110@1|root,COG0110@2|Bacteria,1G7DM@1117|Cyanobacteria	1117|Cyanobacteria	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
TLS2_k127_680315_6	543632.JOJL01000004_gene4289	6.347e-55	203.0	COG1216@1|root,COG1216@2|Bacteria,2GP1N@201174|Actinobacteria,4DGFM@85008|Micromonosporales	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_transf_7C,Glycos_transf_2
TLS2_k127_680315_4	35754.JNYJ01000029_gene9454	1.83e-79	285.0	COG2244@1|root,COG2244@2|Bacteria,2H55P@201174|Actinobacteria,4D9TZ@85008|Micromonosporales	201174|Actinobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3,Polysacc_synt_C
TLS2_k127_680315_5	1174528.JH992898_gene1149	2.467e-70	264.0	COG5610@1|root,COG5610@2|Bacteria,1GBHW@1117|Cyanobacteria,1JK95@1189|Stigonemataceae	1117|Cyanobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_680315_2	639030.JHVA01000001_gene3760	4.256e-136	444.0	COG0579@1|root,COG0579@2|Bacteria,3Y6NN@57723|Acidobacteria	57723|Acidobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K15736	-	-	-	-	ko00000,ko01000	-	-	-	DAO
TLS2_k127_680315_3	118163.Ple7327_1360	6.116e-120	403.0	COG2227@1|root,COG2227@2|Bacteria,1G2VI@1117|Cyanobacteria,3VMCM@52604|Pleurocapsales	1117|Cyanobacteria	H	C-methyltransferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
TLS2_k127_680315_1	1487953.JMKF01000047_gene2121	2.662e-137	452.0	COG2227@1|root,COG2227@2|Bacteria,1G1XD@1117|Cyanobacteria,1HA3C@1150|Oscillatoriales	1117|Cyanobacteria	H	C-methyltransferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_14,Methyltransf_23
TLS2_k127_680315_0	1499967.BAYZ01000104_gene3698	1.727e-144	464.0	COG2227@1|root,COG2227@2|Bacteria,2NQQ9@2323|unclassified Bacteria	2|Bacteria	H	Putative zinc binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
TLS2_k127_6901665_7	671143.DAMO_1275	8.889e-14	72.0	COG0471@1|root,COG0471@2|Bacteria,2NPNA@2323|unclassified Bacteria	2|Bacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K03319,ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47,2.A.47.1	-	-	Na_sulph_symp
TLS2_k127_6901665_0	1123508.JH636446_gene6264	2.877e-282	895.0	COG0823@1|root,COG1262@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1262@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	dap2	-	2.7.11.1,3.4.19.1	ko:K01303,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001,ko01002	-	-	-	DUF1566,FGE-sulfatase,PD40,Peptidase_S9
TLS2_k127_6901665_5	1267534.KB906755_gene3955	1.11e-56	209.0	2BZS5@1|root,2Z9YI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6901665_8	926566.Terro_3076	2.139e-07	57.0	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	copZ	-	-	ko:K07213,ko:K08364	ko04978,map04978	-	-	-	ko00000,ko00001,ko02000	1.A.72.1	-	-	HMA
TLS2_k127_6901665_6	1173028.ANKO01000015_gene4600	1.862e-35	140.0	COG0295@1|root,COG0295@2|Bacteria,1GAJC@1117|Cyanobacteria	1117|Cyanobacteria	F	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
TLS2_k127_6901665_2	886293.Sinac_1427	1.92e-143	468.0	COG0213@1|root,COG0213@2|Bacteria,2IY57@203682|Planctomycetes	203682|Planctomycetes	F	PFAM Glycosyl transferase, family	-	-	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
TLS2_k127_6901665_3	204669.Acid345_3056	2.801e-135	445.0	COG1972@1|root,COG1972@2|Bacteria,3Y2KI@57723|Acidobacteria,2JIKE@204432|Acidobacteriia	204432|Acidobacteriia	F	PFAM Na dependent nucleoside transporter	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
TLS2_k127_6901665_4	204669.Acid345_3055	1.075e-97	328.0	COG0005@1|root,COG0005@2|Bacteria,3Y2MB@57723|Acidobacteria,2JHYE@204432|Acidobacteriia	204432|Acidobacteriia	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	-	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_6901665_1	1267533.KB906740_gene367	8.336e-231	750.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_6925291_1	204669.Acid345_1875	2.535e-80	273.0	COG1259@1|root,COG1259@2|Bacteria,3Y4QD@57723|Acidobacteria,2JJ7J@204432|Acidobacteriia	204432|Acidobacteriia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
TLS2_k127_6925291_0	1382359.JIAL01000001_gene2143	8.835e-228	714.0	COG0621@1|root,COG0621@2|Bacteria,3Y2GT@57723|Acidobacteria,2JIEP@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TLS2_k127_6925291_3	204669.Acid345_1854	1.814e-25	108.0	COG2050@1|root,COG2050@2|Bacteria,3Y57I@57723|Acidobacteria,2JJU4@204432|Acidobacteriia	204432|Acidobacteriia	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_6954274_3	1116472.MGMO_57c00340	1.79e-81	278.0	COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,1RRUD@1236|Gammaproteobacteria,1XFCW@135618|Methylococcales	135618|Methylococcales	S	Glycosyl transferase	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3
TLS2_k127_6954274_0	1382359.JIAL01000001_gene934	2.621e-260	815.0	COG0367@1|root,COG0367@2|Bacteria,3Y75N@57723|Acidobacteria	57723|Acidobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
TLS2_k127_6954274_2	1382359.JIAL01000001_gene933	3.88e-96	325.0	COG1215@1|root,COG1215@2|Bacteria,3Y7RU@57723|Acidobacteria,2JMZ6@204432|Acidobacteriia	204432|Acidobacteriia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_6954274_4	1382359.JIAL01000001_gene932	1.49e-62	231.0	COG0726@1|root,COG0726@2|Bacteria,3Y88K@57723|Acidobacteria,2JNAZ@204432|Acidobacteriia	204432|Acidobacteriia	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_6954274_1	765912.Thimo_3072	4.295e-107	357.0	COG1035@1|root,COG1035@2|Bacteria,1R45V@1224|Proteobacteria,1RSF5@1236|Gammaproteobacteria,1X1N9@135613|Chromatiales	135613|Chromatiales	C	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	FrhB_FdhB_C,FrhB_FdhB_N
TLS2_k127_6998910_1	204669.Acid345_2197	4.211e-08	54.0	COG0458@1|root,COG0458@2|Bacteria,3Y3GG@57723|Acidobacteria,2JIJZ@204432|Acidobacteriia	204432|Acidobacteriia	F	TIGRFAM carbamoyl-phosphate synthase, large subunit	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS2_k127_6998910_0	240015.ACP_0686	1.412e-157	501.0	COG0505@1|root,COG0505@2|Bacteria,3Y31Y@57723|Acidobacteria,2JIB8@204432|Acidobacteriia	204432|Acidobacteriia	F	TIGRFAM Carbamoyl-phosphate synthase, small subunit	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
TLS2_k127_7038643_2	204669.Acid345_0770	3.734e-167	536.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_16,TPR_2,TPR_8
TLS2_k127_7038643_11	204669.Acid345_4754	1.203e-58	211.0	COG1651@1|root,COG1651@2|Bacteria,3Y4S8@57723|Acidobacteria,2JJCA@204432|Acidobacteriia	204432|Acidobacteriia	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
TLS2_k127_7038643_31	1123388.AQWU01000073_gene1152	9.943e-11	68.0	COG0745@1|root,COG0745@2|Bacteria,1WK4G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_7038643_32	396014.BF93_13495	3.701e-10	70.0	COG1309@1|root,COG1309@2|Bacteria,2IDT5@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
TLS2_k127_7038643_24	1185876.BN8_01719	4.471e-23	105.0	COG4319@1|root,COG4319@2|Bacteria,4NSA0@976|Bacteroidetes,47RMW@768503|Cytophagia	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_7038643_19	204669.Acid345_4781	1.315e-29	121.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
TLS2_k127_7038643_34	1322246.BN4_12337	2.494e-06	52.0	COG1225@1|root,COG1225@2|Bacteria,1N9JS@1224|Proteobacteria,42R82@68525|delta/epsilon subdivisions,2WMVA@28221|Deltaproteobacteria,2MBM6@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
TLS2_k127_7038643_7	1123024.AUII01000015_gene3676	1.571e-86	294.0	COG2406@1|root,COG2406@2|Bacteria	2|Bacteria	S	Ferritin, Dps family protein	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TLS2_k127_7038643_21	1123024.AUII01000015_gene3675	2.181e-29	121.0	COG1018@1|root,COG1018@2|Bacteria	2|Bacteria	C	nitric oxide dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Fer2
TLS2_k127_7038643_20	365528.KB891203_gene3445	1.732e-29	123.0	COG0735@1|root,COG0735@2|Bacteria	2|Bacteria	P	belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_7038643_18	204669.Acid345_1970	1.414e-32	132.0	COG0745@1|root,COG0745@2|Bacteria,3Y4TZ@57723|Acidobacteria,2JJI7@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_7038643_4	204669.Acid345_3519	8.231e-92	332.0	COG2202@1|root,COG2203@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y6VM@57723|Acidobacteria,2JKH6@204432|Acidobacteriia	204432|Acidobacteriia	T	PAS PAC sensor signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
TLS2_k127_7038643_27	1380390.JIAT01000010_gene3701	1.964e-17	82.0	COG0467@1|root,COG0467@2|Bacteria,2I5SG@201174|Actinobacteria	201174|Actinobacteria	T	MEDS: MEthanogen/methylotroph, DcmR Sensory domain	-	-	-	-	-	-	-	-	-	-	-	-	MEDS
TLS2_k127_7038643_12	1380390.JIAT01000010_gene3701	2.588e-56	202.0	COG0467@1|root,COG0467@2|Bacteria,2I5SG@201174|Actinobacteria	201174|Actinobacteria	T	MEDS: MEthanogen/methylotroph, DcmR Sensory domain	-	-	-	-	-	-	-	-	-	-	-	-	MEDS
TLS2_k127_7038643_22	743722.Sph21_2661	6.298e-28	123.0	COG4122@1|root,COG4122@2|Bacteria,4PBU0@976|Bacteroidetes,1IZHJ@117747|Sphingobacteriia	976|Bacteroidetes	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
TLS2_k127_7038643_1	204669.Acid345_2410	2.487e-187	604.0	COG0003@1|root,COG0003@2|Bacteria,3Y60Y@57723|Acidobacteria,2JNWS@204432|Acidobacteriia	204432|Acidobacteriia	P	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
TLS2_k127_7038643_25	1380390.JIAT01000015_gene5872	7.11e-21	102.0	2DM5J@1|root,31T6B@2|Bacteria,2GMP8@201174|Actinobacteria	201174|Actinobacteria	S	Gas vesicle	gvpL2	-	-	-	-	-	-	-	-	-	-	-	GvpL_GvpF
TLS2_k127_7038643_15	204669.Acid345_2406	3.024e-35	147.0	arCOG06390@1|root,330IR@2|Bacteria	2|Bacteria	S	Gas vesicle protein K	gvpK	-	-	-	-	-	-	-	-	-	-	-	Gas_vesicle,GvpK
TLS2_k127_7038643_17	204669.Acid345_2405	6.937e-33	130.0	2E5BC@1|root,3303G@2|Bacteria	2|Bacteria	S	Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth	gvpJ	-	-	-	-	-	-	-	-	-	-	-	Gas_vesicle
TLS2_k127_7038643_14	204669.Acid345_2404	8.94e-36	138.0	arCOG03092@1|root,32YMQ@2|Bacteria	2|Bacteria	S	Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure	gvpA	-	-	-	-	-	-	-	-	-	-	-	Gas_vesicle
TLS2_k127_7038643_0	204669.Acid345_2403	1.078e-230	734.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,3Y2RK@57723|Acidobacteria,2JHY1@204432|Acidobacteriia	204432|Acidobacteriia	T	CHASE3 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS
TLS2_k127_7038643_23	204669.Acid345_2402	1.795e-23	108.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	vsrB	-	2.7.13.3	ko:K10819,ko:K20975	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_7,Response_reg
TLS2_k127_7038643_3	204669.Acid345_2401	1.379e-117	385.0	COG0154@1|root,COG0154@2|Bacteria	2|Bacteria	J	amidase activity	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase,GvpL_GvpF
TLS2_k127_7038643_28	1125973.JNLC01000018_gene2333	2.731e-15	81.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2U9GW@28211|Alphaproteobacteria,3JZJK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TLS2_k127_7038643_8	1244869.H261_10452	3.441e-74	265.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2TSQB@28211|Alphaproteobacteria,2JU12@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_7038643_10	1123023.JIAI01000015_gene3354	9.233e-71	249.0	COG4221@1|root,COG4221@2|Bacteria,2I3PD@201174|Actinobacteria,4EE16@85010|Pseudonocardiales	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_7038643_5	85643.Tmz1t_2951	2.702e-87	302.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,2VV78@28216|Betaproteobacteria,2KXPH@206389|Rhodocyclales	206389|Rhodocyclales	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
TLS2_k127_7038643_6	316057.RPD_1537	3.159e-87	304.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,2U31W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	benzoyl-CoA reductase	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
TLS2_k127_7038643_9	398767.Glov_2399	1.469e-71	256.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,43V8M@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	yjiL	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
TLS2_k127_7038643_13	997350.HMPREF9129_0354	9.812e-53	197.0	COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,22GK6@1570339|Peptoniphilaceae	186801|Clostridia	I	cog cog1924	fldI	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
TLS2_k127_7038643_35	671143.DAMO_0766	0.0005208	49.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	pcmB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9	ko:K03388,ko:K12527	ko00450,ko00680,ko01100,ko01120,ko01200,map00450,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R07229,R11928,R11931,R11943,R11944	RC00011,RC02420	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,FlpD,Pyr_redox_2,Pyr_redox_3
TLS2_k127_7038643_33	713586.KB900536_gene1339	7.264e-07	58.0	COG2180@1|root,COG2180@2|Bacteria	2|Bacteria	C	chaperone-mediated protein complex assembly	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh,Nitrate_red_del
TLS2_k127_705436_1	204669.Acid345_1212	2.013e-145	466.0	COG1250@1|root,COG1250@2|Bacteria,3Y3S5@57723|Acidobacteria,2JI6S@204432|Acidobacteriia	57723|Acidobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_705436_8	1250005.PHEL85_3192	6.469e-22	102.0	COG2827@1|root,COG2827@2|Bacteria,4NUYX@976|Bacteroidetes,1I4M9@117743|Flavobacteriia	976|Bacteroidetes	L	GIY-YIG catalytic domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
TLS2_k127_705436_2	204669.Acid345_1213	4.132e-106	350.0	COG1024@1|root,COG1024@2|Bacteria,3Y47B@57723|Acidobacteria,2JIRS@204432|Acidobacteriia	204432|Acidobacteriia	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS2_k127_705436_3	240015.ACP_2328	7.739e-88	299.0	COG0054@1|root,COG0054@2|Bacteria,3Y3RR@57723|Acidobacteria,2JIYX@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
TLS2_k127_705436_6	204669.Acid345_1215	1.156e-56	201.0	COG0781@1|root,COG0781@2|Bacteria,3Y4Z7@57723|Acidobacteria,2JJFX@204432|Acidobacteriia	204432|Acidobacteriia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
TLS2_k127_705436_7	926566.Terro_3750	5.864e-36	156.0	COG3391@1|root,COG3391@2|Bacteria,3Y3JN@57723|Acidobacteria,2JHMY@204432|Acidobacteriia	204432|Acidobacteriia	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_705436_5	639030.JHVA01000001_gene1559	1.788e-71	242.0	COG0048@1|root,COG0048@2|Bacteria,3Y4JQ@57723|Acidobacteria,2JJ7D@204432|Acidobacteriia	204432|Acidobacteriia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
TLS2_k127_705436_4	1382359.JIAL01000001_gene1692	8.485e-84	279.0	COG0049@1|root,COG0049@2|Bacteria,3Y37A@57723|Acidobacteria,2JHRA@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
TLS2_k127_705436_0	204669.Acid345_1223	0.0	1155.0	COG0480@1|root,COG0480@2|Bacteria,3Y2YX@57723|Acidobacteria,2JIQP@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_705436_9	234267.Acid_5120	4.738e-20	89.0	COG0050@1|root,COG0050@2|Bacteria,3Y2JG@57723|Acidobacteria	57723|Acidobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TLS2_k127_7093839_44	204669.Acid345_1224	3.499e-32	125.0	COG0050@1|root,COG0050@2|Bacteria,3Y2JG@57723|Acidobacteria,2JKFY@204432|Acidobacteriia	204432|Acidobacteriia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TLS2_k127_7093839_28	204669.Acid345_1225	1.745e-59	207.0	COG0051@1|root,COG0051@2|Bacteria,3Y4V5@57723|Acidobacteria,2JJAS@204432|Acidobacteriia	204432|Acidobacteriia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
TLS2_k127_7093839_14	1382359.JIAL01000001_gene1696	5.51e-113	368.0	COG0087@1|root,COG0087@2|Bacteria,3Y2H7@57723|Acidobacteria,2JI91@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
TLS2_k127_7093839_16	204669.Acid345_1227	1.476e-99	328.0	COG0088@1|root,COG0088@2|Bacteria,3Y2PM@57723|Acidobacteria,2JIZE@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
TLS2_k127_7093839_34	204669.Acid345_1228	1.858e-43	163.0	COG0089@1|root,COG0089@2|Bacteria,3Y58W@57723|Acidobacteria,2JJR2@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
TLS2_k127_7093839_7	204669.Acid345_1229	2.534e-161	510.0	COG0090@1|root,COG0090@2|Bacteria,3Y3DH@57723|Acidobacteria,2JI2K@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
TLS2_k127_7093839_33	204669.Acid345_1230	1.172e-48	175.0	COG0185@1|root,COG0185@2|Bacteria,3Y560@57723|Acidobacteria,2JJMI@204432|Acidobacteriia	204432|Acidobacteriia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
TLS2_k127_7093839_32	1382359.JIAL01000001_gene1701	3.482e-50	187.0	COG0091@1|root,COG0091@2|Bacteria,3Y4KH@57723|Acidobacteria,2JJ8K@204432|Acidobacteriia	204432|Acidobacteriia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
TLS2_k127_7093839_10	204669.Acid345_1232	6.717e-129	413.0	COG0092@1|root,COG0092@2|Bacteria,3Y3ZN@57723|Acidobacteria,2JIRU@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
TLS2_k127_7093839_21	204669.Acid345_1233	1.205e-79	267.0	COG0197@1|root,COG0197@2|Bacteria,3Y4EG@57723|Acidobacteria,2JJ2G@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
TLS2_k127_7093839_49	1267533.KB906735_gene5122	2.646e-14	78.0	COG0255@1|root,COG0255@2|Bacteria,3Y5KD@57723|Acidobacteria,2JK2D@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
TLS2_k127_7093839_46	204669.Acid345_1235	2.796e-27	118.0	COG0186@1|root,COG0186@2|Bacteria,3Y5I3@57723|Acidobacteria,2JJZQ@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
TLS2_k127_7093839_27	1382359.JIAL01000001_gene1706	3.019e-61	216.0	COG0093@1|root,COG0093@2|Bacteria,3Y4N0@57723|Acidobacteria,2JJ86@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
TLS2_k127_7093839_41	240015.ACP_1440	1.43e-37	143.0	COG0198@1|root,COG0198@2|Bacteria,3Y56T@57723|Acidobacteria,2JJQ2@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
TLS2_k127_7093839_18	204669.Acid345_1238	2.137e-89	297.0	COG0094@1|root,COG0094@2|Bacteria,3Y3PS@57723|Acidobacteria,2JHV4@204432|Acidobacteriia	204432|Acidobacteriia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
TLS2_k127_7093839_43	204669.Acid345_1239	3.499e-32	125.0	COG0199@1|root,COG0199@2|Bacteria,3Y5HM@57723|Acidobacteria,2JK0J@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
TLS2_k127_7093839_25	240015.ACP_1437	8.714e-65	223.0	COG0096@1|root,COG0096@2|Bacteria,3Y4IE@57723|Acidobacteria,2JJ74@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
TLS2_k127_7093839_20	204669.Acid345_1241	1.046e-83	280.0	COG0097@1|root,COG0097@2|Bacteria,3Y496@57723|Acidobacteria,2JJ4H@204432|Acidobacteriia	204432|Acidobacteriia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
TLS2_k127_7093839_35	1267533.KB906735_gene5114	3.164e-42	164.0	COG0256@1|root,COG0256@2|Bacteria,3Y5CH@57723|Acidobacteria,2JMXD@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast	-	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
TLS2_k127_7093839_19	240015.ACP_1434	5.38e-86	287.0	COG0098@1|root,COG0098@2|Bacteria,3Y2FE@57723|Acidobacteria,2JHKR@204432|Acidobacteriia	204432|Acidobacteriia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
TLS2_k127_7093839_47	1267534.KB906757_gene803	1.07e-20	94.0	COG1841@1|root,COG1841@2|Bacteria,3Y5I2@57723|Acidobacteria,2JJZB@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
TLS2_k127_7093839_29	204669.Acid345_1245	1.401e-58	211.0	COG0200@1|root,COG0200@2|Bacteria,3Y4JC@57723|Acidobacteria,2JJ94@204432|Acidobacteriia	204432|Acidobacteriia	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
TLS2_k127_7093839_2	204669.Acid345_1246	1.459e-221	694.0	COG0201@1|root,COG0201@2|Bacteria,3Y38D@57723|Acidobacteria,2JISZ@204432|Acidobacteriia	204432|Acidobacteriia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
TLS2_k127_7093839_24	240015.ACP_1430	2.185e-65	232.0	COG0563@1|root,COG0563@2|Bacteria,3Y421@57723|Acidobacteria,2JI14@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
TLS2_k127_7093839_13	204669.Acid345_1248	1.966e-120	390.0	COG0024@1|root,COG0024@2|Bacteria,3Y2HJ@57723|Acidobacteria,2JI6Z@204432|Acidobacteriia	204432|Acidobacteriia	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS2_k127_7093839_39	204669.Acid345_1249	1.646e-38	144.0	COG0361@1|root,COG0361@2|Bacteria,3Y55Z@57723|Acidobacteria,2JJUQ@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
TLS2_k127_7093839_48	1198114.AciX9_2931	7.308e-16	77.0	COG0257@1|root,COG0257@2|Bacteria,3Y5X6@57723|Acidobacteria,2JK4W@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
TLS2_k127_7093839_30	1382359.JIAL01000001_gene1719	4.768e-56	198.0	COG0099@1|root,COG0099@2|Bacteria,3Y4KC@57723|Acidobacteria,2JJAF@204432|Acidobacteriia	204432|Acidobacteriia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
TLS2_k127_7093839_26	1267533.KB906735_gene5105	9.016e-63	218.0	COG0100@1|root,COG0100@2|Bacteria,3Y4BS@57723|Acidobacteria,2JJ4Q@204432|Acidobacteriia	204432|Acidobacteriia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
TLS2_k127_7093839_36	234267.Acid_3108	3.248e-41	156.0	COG0346@1|root,COG0346@2|Bacteria,3Y5V6@57723|Acidobacteria	57723|Acidobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7093839_17	204669.Acid345_1254	1.033e-96	325.0	COG0522@1|root,COG0522@2|Bacteria,3Y2I1@57723|Acidobacteria,2JHR6@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
TLS2_k127_7093839_3	204669.Acid345_1255	6.674e-185	584.0	COG0202@1|root,COG0202@2|Bacteria,3Y3HK@57723|Acidobacteria,2JHZ6@204432|Acidobacteriia	204432|Acidobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
TLS2_k127_7093839_23	204669.Acid345_1256	1.816e-66	230.0	COG0203@1|root,COG0203@2|Bacteria,3Y4JF@57723|Acidobacteria,2JJ8Q@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
TLS2_k127_7093839_52	926566.Terro_3691	1.839e-08	62.0	COG5652@1|root,COG5652@2|Bacteria,3Y82N@57723|Acidobacteria,2JND5@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM VanZ	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
TLS2_k127_7093839_1	204669.Acid345_1260	1.475e-255	795.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,3Y2I9@57723|Acidobacteria,2JHNT@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TLS2_k127_7093839_31	204669.Acid345_4219	2.732e-54	197.0	COG0779@1|root,COG0779@2|Bacteria,3Y528@57723|Acidobacteria,2JJHJ@204432|Acidobacteriia	204432|Acidobacteriia	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
TLS2_k127_7093839_4	278963.ATWD01000001_gene1785	7.55e-181	580.0	COG0195@1|root,COG0195@2|Bacteria,3Y379@57723|Acidobacteria,2JIAX@204432|Acidobacteriia	204432|Acidobacteriia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
TLS2_k127_7093839_0	204669.Acid345_4217	0.0	1108.0	COG0532@1|root,COG0532@2|Bacteria,3Y3UG@57723|Acidobacteria,2JHXH@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
TLS2_k127_7093839_38	204669.Acid345_4216	4.796e-39	147.0	COG1550@1|root,COG1550@2|Bacteria,3Y5B8@57723|Acidobacteria,2JJUV@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
TLS2_k127_7093839_45	204669.Acid345_4215	5.272e-32	128.0	COG0858@1|root,COG0858@2|Bacteria,3Y4X8@57723|Acidobacteria,2JJIQ@204432|Acidobacteriia	204432|Acidobacteriia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
TLS2_k127_7093839_9	204669.Acid345_4214	1.938e-131	426.0	COG0618@1|root,COG0618@2|Bacteria,3Y2GZ@57723|Acidobacteria,2JI0W@204432|Acidobacteriia	204432|Acidobacteriia	S	DHH family	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TLS2_k127_7093839_11	1382359.JIAL01000001_gene1470	6.42e-128	441.0	COG1807@1|root,COG1807@2|Bacteria,3Y2K3@57723|Acidobacteria,2JHZC@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_7093839_42	525909.Afer_0062	2.054e-32	133.0	29AIP@1|root,2ZXIQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7093839_12	204669.Acid345_4211	1.895e-124	408.0	COG0454@1|root,COG0456@2|Bacteria,3Y3VJ@57723|Acidobacteria,2JHZ9@204432|Acidobacteriia	204432|Acidobacteriia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_7093839_50	1267533.KB906741_gene609	8.893e-12	74.0	2EMVM@1|root,33FHV@2|Bacteria,3Y5YS@57723|Acidobacteria,2JK39@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7093839_37	204669.Acid345_4209	3.776e-40	158.0	2B6R1@1|root,31ZPU@2|Bacteria,3Y4VP@57723|Acidobacteria,2JJGV@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7093839_6	204669.Acid345_4208	2.085e-164	531.0	COG0006@1|root,COG0006@2|Bacteria,3Y3I4@57723|Acidobacteria,2JIWQ@204432|Acidobacteriia	204432|Acidobacteriia	E	Metallopeptidase family M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS2_k127_7093839_40	204669.Acid345_4207	2.069e-38	152.0	COG4912@1|root,COG4912@2|Bacteria,3Y5U2@57723|Acidobacteria,2JNWU@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
TLS2_k127_7093839_15	479434.Sthe_1950	3.423e-106	388.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2G5Q5@200795|Chloroflexi,27Y10@189775|Thermomicrobia	200795|Chloroflexi	EU	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_7093839_5	204669.Acid345_4206	1.58e-165	536.0	COG0591@1|root,COG0591@2|Bacteria,3Y34J@57723|Acidobacteria,2JIBW@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307,ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21,2.A.21.2	-	-	SSF
TLS2_k127_7093839_51	1266908.AQPB01000029_gene2110	1.685e-11	72.0	COG1872@1|root,COG1872@2|Bacteria,1QKJ0@1224|Proteobacteria,1SDPY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DUF167	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
TLS2_k127_7093839_22	204669.Acid345_4204	2.654e-78	269.0	COG0325@1|root,COG0325@2|Bacteria,3Y4CY@57723|Acidobacteria,2JJ6G@204432|Acidobacteriia	204432|Acidobacteriia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
TLS2_k127_7093839_8	1382359.JIAL01000001_gene1061	7.782e-138	450.0	COG1297@1|root,COG1297@2|Bacteria,3Y40W@57723|Acidobacteria,2JI44@204432|Acidobacteriia	204432|Acidobacteriia	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
TLS2_k127_7269517_0	204669.Acid345_0132	0.0	1311.0	COG0525@1|root,COG0525@2|Bacteria,3Y2JY@57723|Acidobacteria,2JIBS@204432|Acidobacteriia	204432|Acidobacteriia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TLS2_k127_7269517_1	204669.Acid345_0133	3.352e-136	439.0	COG0157@1|root,COG0157@2|Bacteria,3Y2H5@57723|Acidobacteria,2JHQE@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the NadC ModD family	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
TLS2_k127_7269517_2	1173028.ANKO01000094_gene2612	7.689e-27	124.0	COG0666@1|root,COG0666@2|Bacteria,1G0E1@1117|Cyanobacteria,1HH7I@1150|Oscillatoriales	1117|Cyanobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
TLS2_k127_729613_6	472759.Nhal_2902	3.772e-94	316.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
TLS2_k127_729613_5	323261.Noc_1255	9.932e-133	439.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales	135613|Chromatiales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_729613_0	472759.Nhal_2900	0.0	1386.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales	135613|Chromatiales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS2_k127_729613_10	1267534.KB906758_gene2411	2.081e-15	78.0	2A08K@1|root,30NBV@2|Bacteria,3Y8T2@57723|Acidobacteria,2JNUB@204432|Acidobacteriia	204432|Acidobacteriia	S	Cysteine-rich CPXCG	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_CPXG
TLS2_k127_729613_7	204669.Acid345_2827	2.469e-91	306.0	COG1136@1|root,COG1136@2|Bacteria,3Y30Q@57723|Acidobacteria,2JI7R@204432|Acidobacteriia	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_729613_4	204669.Acid345_2826	8.956e-143	480.0	COG4591@1|root,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	-	-	-	ko:K02004,ko:K09808	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.125	-	-	FtsX,MacB_PCD
TLS2_k127_729613_8	204669.Acid345_2825	8.044e-86	296.0	COG0627@1|root,COG0627@2|Bacteria,3Y8UN@57723|Acidobacteria	57723|Acidobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
TLS2_k127_729613_3	1382359.JIAL01000001_gene2531	1.231e-194	629.0	COG2304@1|root,COG2304@2|Bacteria,3Y3DR@57723|Acidobacteria,2JHJT@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM VWFA-related Acidobacterial domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_729613_2	1267533.KB906735_gene4950	9.319e-209	690.0	COG5266@1|root,COG5266@2|Bacteria,3Y9F3@57723|Acidobacteria,2JP7I@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_729613_9	278963.ATWD01000001_gene1884	4.364e-26	121.0	2BZIX@1|root,32R56@2|Bacteria,3Y512@57723|Acidobacteria,2JJJC@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_729613_1	247490.KSU1_C1305	3.29e-307	951.0	COG0296@1|root,COG0296@2|Bacteria,2IXS1@203682|Planctomycetes	203682|Planctomycetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TLS2_k127_7307733_0	926560.KE387027_gene549	3.224e-103	344.0	COG3329@1|root,COG3329@2|Bacteria,1WJER@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Na+-dependent bicarbonate transporter superfamily	-	-	-	ko:K07086	-	-	-	-	ko00000	-	-	-	Sbt_1
TLS2_k127_7307733_2	861299.J421_2424	7.966e-34	148.0	2E0D8@1|root,32W02@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7307733_1	518766.Rmar_1357	1.094e-66	246.0	COG1680@1|root,COG1680@2|Bacteria,4NJ0F@976|Bacteroidetes	976|Bacteroidetes	V	Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_7364173_1	204669.Acid345_4366	1.869e-75	260.0	COG4373@1|root,COG4373@2|Bacteria,3Y318@57723|Acidobacteria,2JIZZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Mu-like prophage FluMu protein gp28	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6C
TLS2_k127_7364173_0	204669.Acid345_1198	2.157e-110	363.0	28JM9@1|root,2Z9DT@2|Bacteria,3Y2S6@57723|Acidobacteria,2JIQX@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7364173_3	240015.ACP_2367	5.582e-66	234.0	28IHN@1|root,2Z8IV@2|Bacteria,3Y3Y5@57723|Acidobacteria,2JIXQ@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF3037)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3037
TLS2_k127_7364173_2	204669.Acid345_4363	4.107e-72	250.0	COG4695@1|root,COG4695@2|Bacteria,3Y37R@57723|Acidobacteria,2JHNQ@204432|Acidobacteriia	204432|Acidobacteriia	S	Phage portal protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_portal
TLS2_k127_7411713_1	204669.Acid345_2772	5.728e-207	662.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,3Y9G2@57723|Acidobacteria,2JNWD@204432|Acidobacteriia	204432|Acidobacteriia	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS2_k127_7411713_2	1121405.dsmv_0002	2.175e-114	379.0	COG2890@1|root,COG2890@2|Bacteria,1QTUH@1224|Proteobacteria	1224|Proteobacteria	J	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_7411713_0	234267.Acid_0067	1.02e-254	792.0	COG0174@1|root,COG0174@2|Bacteria	2|Bacteria	E	glutamine synthetase	glnA	GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS2_k127_7411713_3	1458275.AZ34_04995	2.286e-41	158.0	COG4270@1|root,COG4270@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DoxX,DoxX_2
TLS2_k127_7428001_30	204669.Acid345_1284	5.302e-18	87.0	COG1695@1|root,COG1695@2|Bacteria,3Y5C5@57723|Acidobacteria,2JNCX@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_7428001_18	203275.BFO_1928	5.31e-52	199.0	2ES9V@1|root,33JUK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7428001_2	278963.ATWD01000001_gene1650	3.539e-212	670.0	COG0621@1|root,COG0621@2|Bacteria,3Y362@57723|Acidobacteria,2JIYW@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
TLS2_k127_7428001_28	1198114.AciX9_1038	6.82e-22	96.0	COG3024@1|root,COG3024@2|Bacteria,3Y5P1@57723|Acidobacteria,2JK03@204432|Acidobacteriia	204432|Acidobacteriia	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	-	-	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
TLS2_k127_7428001_24	204669.Acid345_2142	4.694e-39	152.0	COG1267@1|root,COG1267@2|Bacteria,3Y4T1@57723|Acidobacteria,2JJH6@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM Phosphatidylglycerophosphatase A	-	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
TLS2_k127_7428001_5	204669.Acid345_2141	4.426e-154	493.0	COG2133@1|root,COG2133@2|Bacteria,3Y98P@57723|Acidobacteria,2JP56@204432|Acidobacteriia	204432|Acidobacteriia	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7428001_4	204669.Acid345_2140	1.376e-162	521.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,3Y466@57723|Acidobacteria,2JHTM@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
TLS2_k127_7428001_21	204669.Acid345_2139	8.557e-41	157.0	COG1514@1|root,COG1514@2|Bacteria,3Y5S7@57723|Acidobacteria,2JNFQ@204432|Acidobacteriia	204432|Acidobacteriia	J	2'-5' RNA ligase superfamily	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
TLS2_k127_7428001_17	240015.ACP_3410	1.261e-52	192.0	COG0344@1|root,COG0344@2|Bacteria,3Y51D@57723|Acidobacteria,2JJFC@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
TLS2_k127_7428001_10	1267533.KB906735_gene4815	8.815e-115	385.0	COG0240@1|root,COG0240@2|Bacteria,3Y3ZH@57723|Acidobacteria,2JINS@204432|Acidobacteriia	204432|Acidobacteriia	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
TLS2_k127_7428001_1	204669.Acid345_3335	2.236e-239	754.0	COG2206@1|root,COG5000@1|root,COG2206@2|Bacteria,COG5000@2|Bacteria,3Y7I5@57723|Acidobacteria,2JMTE@204432|Acidobacteriia	204432|Acidobacteriia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
TLS2_k127_7428001_7	204669.Acid345_3336	3.083e-135	438.0	COG0552@1|root,COG0552@2|Bacteria,3Y3JQ@57723|Acidobacteria,2JIXJ@204432|Acidobacteriia	204432|Acidobacteriia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
TLS2_k127_7428001_6	204669.Acid345_3337	2.289e-153	494.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,3Y2WU@57723|Acidobacteria,2JHYV@204432|Acidobacteriia	204432|Acidobacteriia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	-	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
TLS2_k127_7428001_15	1382359.JIAL01000001_gene2787	6.287e-64	225.0	COG0307@1|root,COG0307@2|Bacteria,3Y4EE@57723|Acidobacteria,2JJ11@204432|Acidobacteriia	204432|Acidobacteriia	H	riboflavin synthase, alpha subunit	-	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
TLS2_k127_7428001_11	1382359.JIAL01000001_gene2223	9.63e-113	376.0	COG1127@1|root,COG1127@2|Bacteria,3Y45H@57723|Acidobacteria,2JHWI@204432|Acidobacteriia	204432|Acidobacteriia	Q	pfam abc	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TLS2_k127_7428001_23	204669.Acid345_2887	3.776e-39	160.0	COG0746@1|root,COG0746@2|Bacteria,3Y5GH@57723|Acidobacteria,2JJWH@204432|Acidobacteriia	204432|Acidobacteriia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TLS2_k127_7428001_14	156889.Mmc1_0977	1.222e-64	233.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	3-beta hydroxysteroid dehydrogenase	MA20_24380	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind
TLS2_k127_7428001_16	1382359.JIAL01000001_gene454	3.879e-56	209.0	COG2823@1|root,COG2823@2|Bacteria,3Y3MJ@57723|Acidobacteria,2JIN1@204432|Acidobacteriia	204432|Acidobacteriia	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS2_k127_7428001_20	204669.Acid345_0614	3.814e-46	171.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,TPR_16,TPR_8
TLS2_k127_7428001_12	204669.Acid345_1591	2.095e-79	276.0	COG1989@1|root,COG1989@2|Bacteria,3Y4VX@57723|Acidobacteria,2JNZH@204432|Acidobacteriia	204432|Acidobacteriia	NOU	Bacterial Peptidase A24 N-terminal domain	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
TLS2_k127_7428001_9	204669.Acid345_1590	5.573e-120	400.0	COG4191@1|root,COG4191@2|Bacteria,3Y3X4@57723|Acidobacteria,2JING@204432|Acidobacteriia	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02668,ko:K07708	ko02020,map02020	M00497,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg,RsbRD_N
TLS2_k127_7428001_3	204669.Acid345_1588	8.017e-207	651.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria,2JKV3@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_7428001_33	582515.KR51_00012890	0.0001124	53.0	COG1413@1|root,COG1413@2|Bacteria,1G1RC@1117|Cyanobacteria	1117|Cyanobacteria	C	PBS lyase HEAT-like repeat	mpeU	-	-	ko:K05384	ko00196,ko01100,map00196,map01100	-	-	-	ko00000,ko00001,ko00194	-	-	-	HEAT_2,HEAT_PBS
TLS2_k127_7428001_32	395965.Msil_2585	2.137e-11	75.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	nirB	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
TLS2_k127_7428001_27	204669.Acid345_1586	3.387e-23	106.0	2F7F1@1|root,33ZVU@2|Bacteria,3Y85X@57723|Acidobacteria,2JN8D@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1569)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1569,DinB_2
TLS2_k127_7428001_22	204669.Acid345_1585	1.022e-39	158.0	28ZWN@1|root,2ZMM4@2|Bacteria,3Y8RZ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7428001_29	204669.Acid345_1592	8.184e-21	101.0	COG3063@1|root,COG3063@2|Bacteria,3Y5SX@57723|Acidobacteria	57723|Acidobacteria	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
TLS2_k127_7428001_13	204669.Acid345_3118	1.265e-66	235.0	COG2885@1|root,COG2885@2|Bacteria,3Y425@57723|Acidobacteria,2JHR8@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS2_k127_7428001_0	204669.Acid345_3117	4.56e-288	896.0	COG0322@1|root,COG0322@2|Bacteria,3Y2Y7@57723|Acidobacteria,2JI6E@204432|Acidobacteriia	204432|Acidobacteriia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_5,UVR,UvrC_HhH_N
TLS2_k127_7428001_19	204669.Acid345_2351	5.834e-52	197.0	2DE9Y@1|root,2ZM4N@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7428001_25	1382359.JIAL01000001_gene1743	1.262e-33	150.0	COG2971@1|root,COG2971@2|Bacteria,3Y2J3@57723|Acidobacteria,2JIGZ@204432|Acidobacteriia	204432|Acidobacteriia	G	BadF/BadG/BcrA/BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
TLS2_k127_7428001_8	204669.Acid345_3352	1.038e-127	429.0	COG0591@1|root,COG0591@2|Bacteria,3Y419@57723|Acidobacteria,2JM46@204432|Acidobacteriia	204432|Acidobacteriia	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_7438620_10	1198114.AciX9_3409	1.206e-07	56.0	arCOG13401@1|root,33MMV@2|Bacteria,3Y5TE@57723|Acidobacteria,2JNR5@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
TLS2_k127_7438620_8	204669.Acid345_4662	1.443e-19	93.0	2EJEF@1|root,33D5F@2|Bacteria,3Y5WQ@57723|Acidobacteria,2JNZ9@204432|Acidobacteriia	204432|Acidobacteriia	S	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_7438620_9	1177154.Y5S_02998	3.28e-09	64.0	COG1585@1|root,COG1585@2|Bacteria,1NA4H@1224|Proteobacteria,1SCWS@1236|Gammaproteobacteria,1XM9J@135619|Oceanospirillales	135619|Oceanospirillales	OU	COG1585 Membrane protein implicated in regulation of membrane protease activity	-	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
TLS2_k127_7438620_2	404589.Anae109_0935	7.954e-140	455.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WKYT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
TLS2_k127_7438620_0	204669.Acid345_4661	2.19e-283	884.0	COG0539@1|root,COG0539@2|Bacteria,3Y3DA@57723|Acidobacteria,2JHS3@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal protein S1	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
TLS2_k127_7438620_4	204669.Acid345_4660	8.576e-70	240.0	COG0537@1|root,COG0537@2|Bacteria,3Y4CN@57723|Acidobacteria,2JJ4P@204432|Acidobacteriia	204432|Acidobacteriia	FG	PFAM Histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
TLS2_k127_7438620_5	204669.Acid345_4658	1.481e-43	167.0	COG3861@1|root,COG3861@2|Bacteria	2|Bacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	puhA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009579,GO:0016020,GO:0034357,GO:0042716,GO:0042717,GO:0044424,GO:0044436,GO:0044444,GO:0044464	-	ko:K13991	ko02020,map02020	-	-	-	ko00000,ko00001,ko00194	-	-	-	DUF2382,PRC,PRCH
TLS2_k127_7438620_1	204669.Acid345_3069	2.693e-173	552.0	COG0162@1|root,COG0162@2|Bacteria,3Y2NC@57723|Acidobacteria,2JHYA@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TLS2_k127_7438620_3	204669.Acid345_3012	2.56e-81	276.0	COG0299@1|root,COG0299@2|Bacteria,3Y49G@57723|Acidobacteria,2JJ2U@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
TLS2_k127_7438620_6	204669.Acid345_1062	1.253e-33	133.0	COG3695@1|root,COG3695@2|Bacteria,3Y5FU@57723|Acidobacteria,2JK0H@204432|Acidobacteriia	204432|Acidobacteriia	L	PFAM Methylated-DNA- protein -cysteine S-methyltransferase DNA binding	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
TLS2_k127_750418_1	1125863.JAFN01000001_gene746	4.36e-43	167.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Y98@68525|delta/epsilon subdivisions,2WTXU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_750418_0	1382359.JIAL01000001_gene945	1.805e-57	206.0	COG1596@1|root,COG1596@2|Bacteria,3Y51C@57723|Acidobacteria,2JJMM@204432|Acidobacteriia	204432|Acidobacteriia	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
TLS2_k127_750418_2	1382359.JIAL01000001_gene944	3.23e-12	76.0	2EF70@1|root,33901@2|Bacteria,3Y5Q5@57723|Acidobacteria,2JJZV@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_758554_2	204669.Acid345_1739	4.316e-161	512.0	COG0761@1|root,COG0761@2|Bacteria,3Y40M@57723|Acidobacteria,2JIXC@204432|Acidobacteriia	204432|Acidobacteriia	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
TLS2_k127_758554_0	240015.ACP_3329	4.557e-313	969.0	COG1657@1|root,COG1657@2|Bacteria,3Y37N@57723|Acidobacteria,2JIJP@204432|Acidobacteriia	204432|Acidobacteriia	I	Squalene-hopene cyclase C-terminal domain	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
TLS2_k127_758554_3	886293.Sinac_2970	2.145e-158	505.0	COG0535@1|root,COG0535@2|Bacteria,2IWZK@203682|Planctomycetes	203682|Planctomycetes	S	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_12,Fer4_14,Radical_SAM
TLS2_k127_758554_5	204669.Acid345_1741	7.84e-142	456.0	COG0451@1|root,COG0451@2|Bacteria,3Y41S@57723|Acidobacteria,2JIV2@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM hopanoid-associated sugar epimerase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
TLS2_k127_758554_8	883080.HMPREF9697_01296	2.04e-07	62.0	COG0775@1|root,COG0775@2|Bacteria,1PETT@1224|Proteobacteria,2TTTB@28211|Alphaproteobacteria,3JRPM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Phosphorylase superfamily	MA20_16045	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_758554_4	204669.Acid345_1743	4.235e-156	500.0	COG1063@1|root,COG1063@2|Bacteria,3Y2H8@57723|Acidobacteria,2JIHW@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_758554_1	204669.Acid345_1744	1.698e-177	565.0	COG1063@1|root,COG1063@2|Bacteria,3Y30Y@57723|Acidobacteria,2JIRR@204432|Acidobacteriia	204432|Acidobacteriia	E	Zinc-binding dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_758554_6	204669.Acid345_1745	1.925e-131	426.0	COG1562@1|root,COG1562@2|Bacteria,3Y3ZV@57723|Acidobacteria,2JIMK@204432|Acidobacteriia	204432|Acidobacteriia	I	Squalene/phytoene synthase	-	-	-	-	-	-	-	-	-	-	-	-	SQS_PSY
TLS2_k127_758554_7	1382359.JIAL01000001_gene373	5.085e-21	96.0	COG1562@1|root,COG1562@2|Bacteria,3Y3YX@57723|Acidobacteria,2JIHF@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM Squalene phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
TLS2_k127_771255_1	204669.Acid345_0621	8.201e-163	529.0	COG0612@1|root,COG0612@2|Bacteria,3Y322@57723|Acidobacteria,2JP25@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16_C
TLS2_k127_771255_4	452637.Oter_0776	0.0001296	54.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2202@1|root,COG3829@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,46Z7I@74201|Verrucomicrobia	74201|Verrucomicrobia	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_4,Response_reg
TLS2_k127_771255_2	204669.Acid345_0620	3.992e-131	426.0	COG1533@1|root,COG1533@2|Bacteria,3Y2S5@57723|Acidobacteria,2JIC8@204432|Acidobacteriia	204432|Acidobacteriia	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_771255_3	383372.Rcas_3791	6.035e-118	392.0	COG4638@1|root,COG4638@2|Bacteria,2G720@200795|Chloroflexi,377BT@32061|Chloroflexia	32061|Chloroflexia	P	PFAM Rieske 2Fe-2S domain protein	-	-	1.14.15.7	ko:K00479,ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
TLS2_k127_771255_0	204669.Acid345_1459	6.029e-252	784.0	COG1012@1|root,COG1012@2|Bacteria,3Y3V5@57723|Acidobacteria,2JIX2@204432|Acidobacteriia	204432|Acidobacteriia	C	Aldehyde dehydrogenase family	-	-	1.2.1.28	ko:K00141,ko:K22187	ko00040,ko00622,ko00623,ko00627,ko01100,ko01120,ko01220,map00040,map00622,map00623,map00627,map01100,map01120,map01220	M00537,M00538	R01293,R01419,R05289,R05663,R05664,R07667,R11768	RC00075,RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_789775_2	204669.Acid345_1410	1.065e-66	233.0	COG2986@1|root,COG2986@2|Bacteria,3Y3YW@57723|Acidobacteria,2JIK6@204432|Acidobacteriia	204432|Acidobacteriia	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
TLS2_k127_789775_3	204669.Acid345_1409	6.881e-48	184.0	COG0824@1|root,COG0824@2|Bacteria,3Y4WZ@57723|Acidobacteria,2JJIE@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
TLS2_k127_789775_1	204669.Acid345_1426	6.47e-95	317.0	COG1024@1|root,COG1024@2|Bacteria,3Y3SE@57723|Acidobacteria,2JIII@204432|Acidobacteriia	204432|Acidobacteriia	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_789775_0	204669.Acid345_1427	2.924e-119	389.0	COG0119@1|root,COG0119@2|Bacteria,3Y2NJ@57723|Acidobacteria,2JI67@204432|Acidobacteriia	204432|Acidobacteriia	E	HMGL-like	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS2_k127_823154_0	251221.35211153	2.704e-218	694.0	COG4805@1|root,COG4805@2|Bacteria,1GC38@1117|Cyanobacteria	1117|Cyanobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS2_k127_823154_1	204669.Acid345_2365	4.353e-09	59.0	COG1703@1|root,COG1703@2|Bacteria,3Y40X@57723|Acidobacteria,2JHW8@204432|Acidobacteriia	204432|Acidobacteriia	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS2_k127_832702_10	243231.GSU3239	2.861e-134	439.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,43TM0@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	TIGRFAM ribonuclease, Rne Rng family	cafA	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
TLS2_k127_832702_26	1333523.L593_08855	1.558e-34	147.0	arCOG12705@1|root,arCOG12705@2157|Archaea,2Y5BC@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_832702_22	234267.Acid_5358	2.388e-48	177.0	COG2318@1|root,COG2318@2|Bacteria,3Y5DP@57723|Acidobacteria	57723|Acidobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_832702_15	1453500.AT05_04525	8.67e-115	386.0	COG0471@1|root,COG0471@2|Bacteria,4NFDK@976|Bacteroidetes,1HX3U@117743|Flavobacteriia	976|Bacteroidetes	P	COG0471 Di- and tricarboxylate	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
TLS2_k127_832702_27	204669.Acid345_1468	4.052e-34	134.0	COG3311@1|root,COG3311@2|Bacteria,3Y5MJ@57723|Acidobacteria,2JJZN@204432|Acidobacteriia	204432|Acidobacteriia	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
TLS2_k127_832702_7	204669.Acid345_1469	6.581e-163	518.0	COG4972@1|root,COG4972@2|Bacteria,3Y804@57723|Acidobacteria	57723|Acidobacteria	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
TLS2_k127_832702_25	204669.Acid345_1470	7.001e-41	157.0	COG3166@1|root,COG3166@2|Bacteria	2|Bacteria	NU	PFAM Fimbrial assembly family protein	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
TLS2_k127_832702_21	204669.Acid345_1471	1.858e-55	201.0	COG3167@1|root,COG3167@2|Bacteria	2|Bacteria	NU	carbon utilization	mshJ	-	-	ko:K02664,ko:K02665,ko:K12280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO,T2SSM,T2SSM_b
TLS2_k127_832702_1	204669.Acid345_1473	3.361e-225	725.0	COG4796@1|root,COG4796@2|Bacteria,3Y98D@57723|Acidobacteria	57723|Acidobacteria	U	Secretin and TonB N terminus short domain	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,Secretin,Secretin_N
TLS2_k127_832702_14	1267534.KB906756_gene27	2.83e-116	387.0	COG0006@1|root,COG0006@2|Bacteria,3Y3IN@57723|Acidobacteria,2JI8R@204432|Acidobacteriia	204432|Acidobacteriia	E	Creatinase/Prolidase N-terminal domain	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
TLS2_k127_832702_23	204669.Acid345_3288	1.329e-46	175.0	COG0511@1|root,COG0511@2|Bacteria,3Y4W8@57723|Acidobacteria,2JJHQ@204432|Acidobacteriia	204432|Acidobacteriia	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
TLS2_k127_832702_0	204669.Acid345_3287	7.846e-237	739.0	COG0439@1|root,COG0439@2|Bacteria,3Y2QZ@57723|Acidobacteria,2JIFS@204432|Acidobacteriia	204432|Acidobacteriia	I	acetyl-CoA carboxylase, biotin carboxylase	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TLS2_k127_832702_20	204669.Acid345_3286	9.469e-62	219.0	COG0352@1|root,COG0352@2|Bacteria,3Y4Y5@57723|Acidobacteria,2JJM3@204432|Acidobacteriia	204432|Acidobacteriia	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TLS2_k127_832702_4	204669.Acid345_3285	3.749e-196	623.0	COG0531@1|root,COG0531@2|Bacteria,3Y3QM@57723|Acidobacteria,2JIFD@204432|Acidobacteriia	204432|Acidobacteriia	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_832702_12	518766.Rmar_2112	1.821e-129	428.0	COG0733@1|root,COG0733@2|Bacteria,4NGQ5@976|Bacteroidetes,1FJPU@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
TLS2_k127_832702_13	340099.Teth39_0432	2.544e-120	402.0	COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,42FA0@68295|Thermoanaerobacterales	186801|Clostridia	E	amino acid carrier protein	agcS	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
TLS2_k127_832702_6	204669.Acid345_3282	2.931e-165	537.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,3Y3XN@57723|Acidobacteria,2JIPF@204432|Acidobacteriia	204432|Acidobacteriia	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
TLS2_k127_832702_24	1267533.KB906733_gene3391	1.505e-41	158.0	COG0802@1|root,COG0802@2|Bacteria,3Y4WF@57723|Acidobacteria,2JMZQ@204432|Acidobacteriia	204432|Acidobacteriia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
TLS2_k127_832702_16	1267533.KB906733_gene3392	3.819e-113	385.0	COG0623@1|root,COG0623@2|Bacteria,3Y3EN@57723|Acidobacteria,2JHZZ@204432|Acidobacteriia	204432|Acidobacteriia	I	Enoyl- acyl-carrier-protein reductase NADH	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_832702_18	204669.Acid345_3277	1.031e-93	312.0	COG4122@1|root,COG4122@2|Bacteria,3Y43N@57723|Acidobacteria,2JI23@204432|Acidobacteriia	204432|Acidobacteriia	S	Cephalosporin hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
TLS2_k127_832702_28	880072.Desac_2180	5.233e-32	130.0	COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,42W70@68525|delta/epsilon subdivisions,2WRUT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
TLS2_k127_832702_9	1121920.AUAU01000031_gene1411	5.796e-137	447.0	COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	-	-	-	-	-	-	-	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS2_k127_832702_11	1288494.EBAPG3_31440	2.012e-131	437.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2VKEE@28216|Betaproteobacteria,371XI@32003|Nitrosomonadales	28216|Betaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_832702_30	204669.Acid345_3276	2.875e-11	71.0	2EEQA@1|root,338HZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_832702_3	204669.Acid345_3275	4.1e-214	682.0	COG5000@1|root,COG5000@2|Bacteria,3Y32Z@57723|Acidobacteria,2JP5E@204432|Acidobacteriia	204432|Acidobacteriia	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_832702_2	204669.Acid345_3274	2.221e-222	701.0	COG2204@1|root,COG2204@2|Bacteria,3Y3HH@57723|Acidobacteria,2JI5D@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_832702_31	1267534.KB906759_gene1864	1.495e-09	69.0	2EK74@1|root,33DXH@2|Bacteria,3Y5VZ@57723|Acidobacteria,2JK2Y@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_832702_17	204669.Acid345_3272	5.458e-104	357.0	COG2885@1|root,COG2885@2|Bacteria,3Y310@57723|Acidobacteria,2JI18@204432|Acidobacteriia	204432|Acidobacteriia	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS2_k127_832702_5	204669.Acid345_3271	1.299e-191	620.0	COG3292@1|root,COG4447@1|root,COG3292@2|Bacteria,COG4447@2|Bacteria,3Y3Y6@57723|Acidobacteria,2JI5Y@204432|Acidobacteriia	204432|Acidobacteriia	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
TLS2_k127_832702_19	861299.J421_5728	9.859e-67	245.0	COG4191@1|root,COG4936@1|root,COG4191@2|Bacteria,COG4936@2|Bacteria,1ZUC5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
TLS2_k127_832702_8	204669.Acid345_3269	6.351e-148	473.0	COG2204@1|root,COG2204@2|Bacteria,3Y3HZ@57723|Acidobacteria,2JI47@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_872474_2	1379270.AUXF01000001_gene2742	1.045e-48	181.0	COG2866@1|root,COG2866@2|Bacteria,1ZSMP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS2_k127_872474_1	1267535.KB906767_gene3254	6.584e-83	283.0	COG1801@1|root,COG1801@2|Bacteria,3Y2F1@57723|Acidobacteria,2JHKY@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS2_k127_872474_0	234267.Acid_7842	1.387e-106	352.0	COG1273@1|root,COG1273@2|Bacteria,3Y4E7@57723|Acidobacteria	57723|Acidobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	-	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
TLS2_k127_931245_1	1411123.JQNH01000001_gene2444	1.413e-20	101.0	COG4106@1|root,COG4106@2|Bacteria,1R08A@1224|Proteobacteria,2TYN4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_931245_0	1173029.JH980292_gene2487	4.027e-167	537.0	COG1232@1|root,COG1232@2|Bacteria,1G465@1117|Cyanobacteria,1H9AU@1150|Oscillatoriales	1117|Cyanobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS2_k127_9398_4	1335757.SPICUR_06740	3.537e-06	50.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_9398_1	204669.Acid345_0775	1.405e-31	135.0	COG1266@1|root,COG1266@2|Bacteria,3Y54S@57723|Acidobacteria,2JJN3@204432|Acidobacteriia	204432|Acidobacteriia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_9398_0	204669.Acid345_1176	1.603e-65	231.0	COG0461@1|root,COG0461@2|Bacteria,3Y4ID@57723|Acidobacteria,2JJDT@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
TLS2_k127_9398_2	56107.Cylst_3291	1.203e-17	90.0	2BP8K@1|root,30XWS@2|Bacteria,1GK76@1117|Cyanobacteria,1HTDZ@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_9398_3	204669.Acid345_1175	6.405e-11	64.0	COG0182@1|root,COG0182@2|Bacteria,3Y2TR@57723|Acidobacteria,2JHZX@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
TLS2_k127_950085_0	861299.J421_1360	6.778e-42	162.0	COG2132@1|root,COG2132@2|Bacteria,1ZUD9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22348	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
TLS2_k127_950085_1	204669.Acid345_0450	3.719e-07	60.0	COG4934@1|root,COG4934@2|Bacteria,3Y37M@57723|Acidobacteria	57723|Acidobacteria	O	peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Peptidase_S8,Pro-kuma_activ
TLS2_k127_952765_15	204669.Acid345_2976	8.694e-19	91.0	COG0704@1|root,COG0704@2|Bacteria	2|Bacteria	P	negative regulation of phosphate transmembrane transport	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TLS2_k127_952765_3	204669.Acid345_2989	9.77e-168	546.0	COG5002@1|root,COG5002@2|Bacteria,3Y3AX@57723|Acidobacteria,2JI3A@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_7
TLS2_k127_952765_5	204669.Acid345_2990	4.561e-106	349.0	COG0745@1|root,COG0745@2|Bacteria,3Y38C@57723|Acidobacteria,2JIPX@204432|Acidobacteriia	204432|Acidobacteriia	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483,ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_952765_11	1128421.JAGA01000003_gene2889	4.484e-31	131.0	COG1320@1|root,COG1320@2|Bacteria,2NRQF@2323|unclassified Bacteria	2|Bacteria	P	Na+/H+ antiporter subunit	mrpG	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
TLS2_k127_952765_14	396588.Tgr7_2523	1.901e-19	91.0	COG2212@1|root,COG2212@2|Bacteria,1N7BC@1224|Proteobacteria	1224|Proteobacteria	P	Multisubunit Na H antiporter, MnhF subunit	mnhF	-	-	ko:K05563,ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
TLS2_k127_952765_7	1128421.JAGA01000003_gene2887	3.16e-56	204.0	COG1863@1|root,COG1863@2|Bacteria	2|Bacteria	P	multisubunit Na H antiporter MnhE subunit	mrpE	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
TLS2_k127_952765_2	1128421.JAGA01000003_gene2886	5.38e-202	640.0	COG0651@1|root,COG0651@2|Bacteria,2NS4P@2323|unclassified Bacteria	2|Bacteria	CP	Proton-conducting membrane transporter	mrpD	GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600	-	ko:K05568,ko:K12141	-	-	-	-	ko00000,ko01000,ko02000	2.A.63.1,2.A.63.2	-	iSB619.SA_RS04615	Proton_antipo_M
TLS2_k127_952765_8	237368.SCABRO_02532	5.314e-39	148.0	COG1006@1|root,COG1006@2|Bacteria,2J0V2@203682|Planctomycetes	203682|Planctomycetes	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
TLS2_k127_952765_9	519989.ECTPHS_09939	1.889e-37	158.0	COG2111@1|root,COG2111@2|Bacteria,1REGG@1224|Proteobacteria,1S6WN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Na H antiporter, MnhB	mnhB	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MnhB
TLS2_k127_952765_0	1128421.JAGA01000003_gene2883	6.462e-240	764.0	COG1009@1|root,COG1009@2|Bacteria	2|Bacteria	CP	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit	mrpA	GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600	-	ko:K05559,ko:K05565	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
TLS2_k127_952765_12	886293.Sinac_6575	3.357e-29	126.0	COG5266@1|root,COG5266@2|Bacteria	2|Bacteria	P	PFAM Nickel transport complex, NikM subunit, transmembrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF4198
TLS2_k127_952765_10	1267533.KB906736_gene1023	9.293e-36	141.0	COG1695@1|root,COG1695@2|Bacteria,3Y7W2@57723|Acidobacteria,2JN2W@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_952765_4	234267.Acid_1737	1.09e-140	484.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_952765_13	1128421.JAGA01000003_gene2880	6.2e-20	93.0	2ASAK@1|root,31HPU@2|Bacteria,2NQ6K@2323|unclassified Bacteria	2|Bacteria	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
TLS2_k127_952765_6	204669.Acid345_2994	5.168e-70	246.0	COG1845@1|root,COG1845@2|Bacteria,3Y414@57723|Acidobacteria,2JI50@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
TLS2_k127_952765_1	234267.Acid_0498	5.983e-218	681.0	COG0843@1|root,COG0843@2|Bacteria,3Y2X6@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS2_k127_965056_1	1089550.ATTH01000001_gene1807	2.802e-45	172.0	COG1215@1|root,COG1215@2|Bacteria,4NF6C@976|Bacteroidetes,1FK1E@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_965056_0	1052684.PPM_3216	1.46e-222	714.0	COG0236@1|root,COG2227@1|root,COG3321@1|root,COG4221@1|root,COG0236@2|Bacteria,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	pksL	-	-	ko:K13613,ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
TLS2_k127_965693_1	1267533.KB906740_gene331	2.954e-148	475.0	COG0022@1|root,COG0022@2|Bacteria,3Y34Y@57723|Acidobacteria,2JHQ9@204432|Acidobacteriia	2|Bacteria	C	Dehydrogenase E1 component	bfmBA	-	1.2.4.4	ko:K00167,ko:K11381,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
TLS2_k127_965693_4	2055.JNXA01000003_gene4565	1.443e-08	63.0	COG3467@1|root,COG3467@2|Bacteria,2IFJS@201174|Actinobacteria,4GA5V@85026|Gordoniaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_965693_0	204669.Acid345_4350	1.404e-153	498.0	COG0508@1|root,COG0508@2|Bacteria,3Y3CV@57723|Acidobacteria,2JHPY@204432|Acidobacteriia	204432|Acidobacteriia	C	e3 binding domain	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_965693_2	204669.Acid345_4352	7.745e-32	126.0	2FGSV@1|root,348N7@2|Bacteria,3Y8KA@57723|Acidobacteria,2JNDA@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_965693_3	1089549.AZUQ01000001_gene2759	9.874e-15	79.0	COG1705@1|root,COG1705@2|Bacteria,2I9NY@201174|Actinobacteria,4EYVP@85014|Glycomycetales	201174|Actinobacteria	NU	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	acm2	-	-	ko:K02395	-	-	-	-	ko00000,ko02035	-	-	-	Glucosaminidase,LGFP,SH3_3
TLS2_k127_980530_13	234267.Acid_5685	2.066e-17	82.0	COG1143@1|root,COG1143@2|Bacteria,3Y529@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
TLS2_k127_980530_10	240015.ACP_1748	9.608e-53	191.0	COG0590@1|root,COG0590@2|Bacteria,3Y4KB@57723|Acidobacteria,2JJC6@204432|Acidobacteriia	204432|Acidobacteriia	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	DUF3175,MafB19-deam
TLS2_k127_980530_8	234267.Acid_5262	1.569e-96	325.0	COG2318@1|root,COG2318@2|Bacteria,3Y7AE@57723|Acidobacteria	57723|Acidobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS2_k127_980530_1	1237149.C900_02054	6.508e-304	953.0	COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes,47YDB@768503|Cytophagia	976|Bacteroidetes	O	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
TLS2_k127_980530_0	240015.ACP_3337	0.0	1677.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3Y37Y@57723|Acidobacteria,2JI9E@204432|Acidobacteriia	204432|Acidobacteriia	E	Vitamin B12 dependent methionine synthase activation	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TLS2_k127_980530_9	204669.Acid345_1845	4.659e-82	276.0	COG1143@1|root,COG1143@2|Bacteria,3Y371@57723|Acidobacteria,2JHYZ@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
TLS2_k127_980530_3	204669.Acid345_2187	1.115e-167	534.0	COG4948@1|root,COG4948@2|Bacteria,3Y2QQ@57723|Acidobacteria,2JITG@204432|Acidobacteriia	204432|Acidobacteriia	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_980530_7	204669.Acid345_2186	6.641e-106	351.0	COG3375@1|root,COG3375@2|Bacteria,3Y41E@57723|Acidobacteria,2JI86@204432|Acidobacteriia	204432|Acidobacteriia	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_980530_6	204669.Acid345_2185	2.182e-109	361.0	COG1694@1|root,COG3956@2|Bacteria,3Y46M@57723|Acidobacteria,2JIEQ@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM MazG family protein	-	-	3.6.1.66,3.6.1.9	ko:K02428,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R01855,R02100,R02720,R03004,R03036,R03531,R11323	RC00002	ko00000,ko00001,ko01000	-	-	-	MazG
TLS2_k127_980530_5	204669.Acid345_3694	9.773e-114	386.0	COG0578@1|root,COG0578@2|Bacteria	2|Bacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	-	-	1.1.5.3,3.1.21.3	ko:K00111,ko:K01153	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000,ko02048	-	-	-	DAO,DAO_C,DUF4145,EcoEI_R_C,FAD_oxidored,HSDR_N,Helicase_C,ResIII
TLS2_k127_980530_11	204669.Acid345_2183	1.007e-46	176.0	COG0584@1|root,COG0584@2|Bacteria	2|Bacteria	C	glycerophosphodiester phosphodiesterase activity	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS2_k127_980530_12	1382359.JIAL01000001_gene2857	2.147e-33	131.0	2CBGA@1|root,32RQS@2|Bacteria,3Y586@57723|Acidobacteria,2JJU2@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_980530_4	204669.Acid345_2181	5.531e-145	477.0	COG4365@1|root,COG4365@2|Bacteria,3Y4D6@57723|Acidobacteria,2JKER@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the BshC family	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
TLS2_k127_980530_2	234267.Acid_5969	1.657e-185	591.0	COG0076@1|root,COG0076@2|Bacteria,3Y365@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
TLS2_k127_99504_0	460265.Mnod_1525	5.608e-114	379.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3
## 2793 queries scanned
## Total time (seconds): 156.47116017341614
## Rate: 17.85 q/s