## Thu Oct 17 15:04:07 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/TLS2_bin.41.fa -m mmseqs --itype genome -o TLS2_bin.41 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/TLS2_bin.41 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TLS2_k127_1000750_5	886293.Sinac_0531	2.449e-49	190.0	COG3049@1|root,COG3049@2|Bacteria	2|Bacteria	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	AAT,AMPK1_CBM,CBAH
TLS2_k127_1000750_3	448385.sce0132	2.859e-114	377.0	COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria,42NYF@68525|delta/epsilon subdivisions,2WIT2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
TLS2_k127_1000750_0	344747.PM8797T_24341	1.308e-200	639.0	COG1012@1|root,COG1012@2|Bacteria,2J2QD@203682|Planctomycetes	203682|Planctomycetes	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_1000750_1	886293.Sinac_5715	1.074e-172	556.0	COG3356@1|root,COG3356@2|Bacteria,2J2EY@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1000750_9	1123248.KB893314_gene3535	2.057e-05	55.0	COG2350@1|root,COG2350@2|Bacteria,4NNMS@976|Bacteroidetes,1ITUD@117747|Sphingobacteriia	976|Bacteroidetes	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_1000750_2	244582.JQAK01000004_gene123	3.574e-116	389.0	COG2271@1|root,COG2271@2|Bacteria,1MX4V@1224|Proteobacteria,2U6FF@28211|Alphaproteobacteria,47FIT@766|Rickettsiales	766|Rickettsiales	G	Sugar phosphate permease	uhpC	-	-	ko:K02445	-	-	-	-	ko00000,ko02000	2.A.1.4.3	-	-	MFS_1
TLS2_k127_1000750_6	1532557.JL37_08115	1.006e-35	147.0	COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,2VMCM@28216|Betaproteobacteria,3T4CS@506|Alcaligenaceae	28216|Betaproteobacteria	I	Domain of unknown function (DUF1932)	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	DUF1932,NAD_binding_2
TLS2_k127_1000750_4	1205680.CAKO01000029_gene5076	5.505e-87	296.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2U0HR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
TLS2_k127_1000750_7	234267.Acid_3946	9.291e-25	112.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_3
TLS2_k127_1000750_8	1121104.AQXH01000004_gene27	1.076e-10	73.0	COG4447@1|root,COG4447@2|Bacteria,4P16I@976|Bacteroidetes,1IWTV@117747|Sphingobacteriia	976|Bacteroidetes	G	SPTR Glycosyl hydrolase, BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
TLS2_k127_1006167_2	309801.trd_1931	2.579e-212	662.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia	189775|Thermomicrobia	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
TLS2_k127_1006167_0	1382356.JQMP01000004_gene485	5.098e-274	857.0	COG0366@1|root,COG0366@2|Bacteria,2G89J@200795|Chloroflexi,27XYW@189775|Thermomicrobia	189775|Thermomicrobia	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
TLS2_k127_1006167_3	1038859.AXAU01000010_gene1875	1.043e-44	167.0	COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,2U6TZ@28211|Alphaproteobacteria,3JY5R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
TLS2_k127_1006167_1	710687.KI912270_gene5280	5.047e-266	825.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,23324@1762|Mycobacteriaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX_1	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS2_k127_1024709_8	682795.AciX8_2551	2.5e-05	48.0	COG0457@1|root,COG0457@2|Bacteria,3Y46H@57723|Acidobacteria,2JHKM@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1024709_1	1408473.JHXO01000013_gene504	1.697e-189	604.0	COG0554@1|root,COG0554@2|Bacteria,4NFUH@976|Bacteroidetes,2G32Z@200643|Bacteroidia	976|Bacteroidetes	H	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS2_k127_1024709_0	1408473.JHXO01000013_gene505	1.35e-206	651.0	COG2407@1|root,COG2407@2|Bacteria,4NFGS@976|Bacteroidetes,2FMDZ@200643|Bacteroidia	976|Bacteroidetes	G	L-fucose isomerase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Fucose_iso_C
TLS2_k127_1024709_6	1144343.PMI41_02862	7.66e-74	263.0	COG1879@1|root,COG1879@2|Bacteria,1N64T@1224|Proteobacteria,2UD6Y@28211|Alphaproteobacteria,43Q30@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TLS2_k127_1024709_4	1382306.JNIM01000001_gene2809	9.484e-112	372.0	COG3959@1|root,COG3959@2|Bacteria,2GA6J@200795|Chloroflexi	200795|Chloroflexi	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS2_k127_1024709_3	1382306.JNIM01000001_gene2808	8.099e-128	416.0	COG3958@1|root,COG3958@2|Bacteria,2G8E1@200795|Chloroflexi	200795|Chloroflexi	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_1024709_2	632518.Calow_0325	2.298e-188	612.0	COG5512@1|root,COG5512@2|Bacteria,1TR27@1239|Firmicutes,247Z8@186801|Clostridia,42HVD@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF4038)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
TLS2_k127_1024709_7	1122176.KB903532_gene2707	8.397e-31	141.0	COG1409@1|root,COG1409@2|Bacteria,4NGK2@976|Bacteroidetes,1IYA9@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Fn3_assoc,Metallophos,PA14,Pur_ac_phosph_N
TLS2_k127_1024709_5	234267.Acid_2813	8.731e-80	279.0	COG0577@1|root,COG0577@2|Bacteria,3Y6QF@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_1036669_2	289376.THEYE_A0717	1.118e-41	158.0	COG0181@1|root,COG0181@2|Bacteria,3J0GC@40117|Nitrospirae	40117|Nitrospirae	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
TLS2_k127_1036669_0	398767.Glov_0503	8.08e-112	375.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,43SX3@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
TLS2_k127_1036669_1	1167006.UWK_00428	1.733e-47	181.0	COG0755@1|root,COG0755@2|Bacteria,1RCCI@1224|Proteobacteria,42PVM@68525|delta/epsilon subdivisions,2WJ7I@28221|Deltaproteobacteria,2MHT7@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
TLS2_k127_1036669_3	204669.Acid345_3859	2.222e-19	90.0	COG1994@1|root,COG1994@2|Bacteria,3Y58P@57723|Acidobacteria,2JJUI@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
TLS2_k127_1051590_4	1193181.BN10_520057	3.032e-12	71.0	COG1216@1|root,COG1216@2|Bacteria,2GK2D@201174|Actinobacteria,4FHZD@85021|Intrasporangiaceae	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
TLS2_k127_1051590_2	696747.NIES39_M01890	9.34e-36	149.0	COG1216@1|root,COG1216@2|Bacteria,1G1PB@1117|Cyanobacteria,1H7B5@1150|Oscillatoriales	1117|Cyanobacteria	S	glycosyl transferase family 2	wcaA	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_1051590_0	1128421.JAGA01000002_gene1117	1.692e-83	293.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,2NPYM@2323|unclassified Bacteria	2|Bacteria	L	Glycosyltransferase like family 2	gumK	-	2.4.1.264	ko:K07011,ko:K13659	-	-	R09732	RC00005,RC00049	ko00000,ko01000,ko01003	-	GT70	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_1,Glycos_transf_2
TLS2_k127_1051590_1	1041930.Mtc_0609	5.912e-54	202.0	COG1216@1|root,arCOG01383@2157|Archaea,2XW51@28890|Euryarchaeota,2N9HF@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase family group 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
TLS2_k127_1051590_3	1128421.JAGA01000002_gene1116	3.987e-14	80.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_105322_0	1340493.JNIF01000004_gene349	7.401e-224	703.0	COG0056@1|root,COG0056@2|Bacteria,3Y2R6@57723|Acidobacteria	57723|Acidobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
TLS2_k127_105322_2	483219.LILAB_11255	1.007e-24	110.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,42U68@68525|delta/epsilon subdivisions,2WQJS@28221|Deltaproteobacteria,2YVS8@29|Myxococcales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
TLS2_k127_105322_4	1047013.AQSP01000132_gene1699	3.66e-08	63.0	COG0711@1|root,COG0711@2|Bacteria	2|Bacteria	C	ATP synthesis coupled proton transport	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02109,ko:K18682	ko00190,ko00195,ko01100,ko03018,map00190,map00195,map01100,map03018	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000,ko03019	3.A.2.1	-	-	ATP-synt_B
TLS2_k127_105322_5	562970.Btus_3237	1.525e-05	53.0	COG0711@1|root,COG0711@2|Bacteria,1VB85@1239|Firmicutes,4HM64@91061|Bacilli,278GQ@186823|Alicyclobacillaceae	91061|Bacilli	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iYO844.BSU36850	ATP-synt_B
TLS2_k127_105322_1	402777.KB235904_gene4517	6.083e-31	125.0	COG0448@1|root,COG0448@2|Bacteria,1G0IG@1117|Cyanobacteria,1H7C1@1150|Oscillatoriales	1117|Cyanobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.agp,iSbBS512_1146.agp	NTP_transferase
TLS2_k127_1055192_3	686340.Metal_2137	2.332e-51	186.0	COG0454@1|root,COG0456@2|Bacteria,1N29T@1224|Proteobacteria,1S8SC@1236|Gammaproteobacteria,1XFVH@135618|Methylococcales	135618|Methylococcales	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_1055192_0	686340.Metal_2136	1.423e-91	310.0	COG4675@1|root,COG4675@2|Bacteria,1MZY9@1224|Proteobacteria,1S64Y@1236|Gammaproteobacteria,1XFRZ@135618|Methylococcales	1236|Gammaproteobacteria	S	PFAM Phage Tail Collar	-	-	-	-	-	-	-	-	-	-	-	-	Collar
TLS2_k127_1055192_1	686340.Metal_2135	3.1e-84	285.0	COG4675@1|root,COG4675@2|Bacteria,1MZY9@1224|Proteobacteria,1S64Y@1236|Gammaproteobacteria,1XFRZ@135618|Methylococcales	135618|Methylococcales	S	PFAM Phage Tail Collar	-	-	-	-	-	-	-	-	-	-	-	-	Collar
TLS2_k127_1055192_2	686340.Metal_2134	1.266e-83	280.0	COG4675@1|root,COG4675@2|Bacteria,1MZY9@1224|Proteobacteria,1S64Y@1236|Gammaproteobacteria,1XFRZ@135618|Methylococcales	1236|Gammaproteobacteria	S	PFAM Phage Tail Collar	-	-	-	-	-	-	-	-	-	-	-	-	Collar
TLS2_k127_1055192_4	1279009.ADICEAN_02096	3.349e-51	184.0	COG3210@1|root,COG4733@1|root,COG3210@2|Bacteria,COG4733@2|Bacteria,4PPRP@976|Bacteroidetes	976|Bacteroidetes	U	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1065261_1	234267.Acid_5783	1.891e-93	313.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_1065261_0	404380.Gbem_4004	7.151e-129	430.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43U53@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran,OEP
TLS2_k127_1076008_1	1454004.AW11_02489	5.351e-29	121.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,2VTJU@28216|Betaproteobacteria	28216|Betaproteobacteria	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
TLS2_k127_1076008_0	522306.CAP2UW1_1748	7.121e-39	159.0	COG0394@1|root,COG0704@1|root,COG0394@2|Bacteria,COG0704@2|Bacteria	2|Bacteria	P	negative regulation of phosphate transmembrane transport	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	1.20.4.1,3.1.3.48	ko:K01104,ko:K02039,ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	PhoU
TLS2_k127_1076008_2	716928.AJQT01000056_gene587	1.201e-27	125.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2TQSH@28211|Alphaproteobacteria,4BJM1@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_1076008_3	204669.Acid345_0766	2.669e-07	60.0	2E6AH@1|root,330YD@2|Bacteria,3Y8MQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1085335_11	471854.Dfer_5258	1.393e-13	70.0	COG0673@1|root,COG0673@2|Bacteria,4NN43@976|Bacteroidetes,47UBC@768503|Cytophagia	976|Bacteroidetes	Q	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_1085335_0	671143.DAMO_2206	2.29e-279	872.0	COG0488@1|root,COG0488@2|Bacteria,2NNP9@2323|unclassified Bacteria	2|Bacteria	S	ABC transporter	uup	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
TLS2_k127_1085335_4	518766.Rmar_1990	3.137e-125	411.0	COG4257@1|root,COG4257@2|Bacteria	2|Bacteria	V	antibiotic catabolic process	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	DUF5011
TLS2_k127_1085335_5	1121904.ARBP01000013_gene308	8.671e-105	361.0	28HHT@1|root,2Z7TE@2|Bacteria,4NIHS@976|Bacteroidetes,47MAA@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1085335_7	1123248.KB893328_gene937	3.736e-67	240.0	COG1082@1|root,COG1082@2|Bacteria,4NG1K@976|Bacteroidetes,1IQA4@117747|Sphingobacteriia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_1085335_2	313603.FB2170_04535	4.589e-152	492.0	COG3964@1|root,COG3964@2|Bacteria,4NI4W@976|Bacteroidetes,1I06U@117743|Flavobacteriia	976|Bacteroidetes	S	Amidohydrolase family	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
TLS2_k127_1085335_9	1340493.JNIF01000004_gene780	9.552e-54	192.0	COG0251@1|root,COG0251@2|Bacteria,3Y4PU@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS2_k127_1085335_1	234267.Acid_6148	2.211e-168	548.0	COG1921@1|root,COG1921@2|Bacteria,3Y6KN@57723|Acidobacteria	57723|Acidobacteria	E	L-seryl-tRNASec selenium transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1085335_6	1291050.JAGE01000001_gene886	1.026e-74	257.0	2BW4G@1|root,2ZAQH@2|Bacteria,1UZFJ@1239|Firmicutes,24DAB@186801|Clostridia,3WN0Q@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1085335_3	518766.Rmar_2102	1.977e-137	459.0	COG0464@1|root,COG0464@2|Bacteria,4P1Y0@976|Bacteroidetes,1FIZT@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
TLS2_k127_1085335_8	401526.TcarDRAFT_0523	8.845e-54	195.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,4H2GI@909932|Negativicutes	909932|Negativicutes	P	ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_1091858_8	1195246.AGRI_14810	1.254e-09	68.0	COG4726@1|root,COG4726@2|Bacteria,1NK1B@1224|Proteobacteria,1SGXT@1236|Gammaproteobacteria,46C5U@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	PilX N-terminal	-	-	-	ko:K02673	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilX_N
TLS2_k127_1091858_9	187272.Mlg_0860	6.035e-07	62.0	COG4726@1|root,COG4726@2|Bacteria,1NQF4@1224|Proteobacteria	1224|Proteobacteria	NU	Pilus assembly protein PilX	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1091858_3	264732.Moth_0915	1.173e-103	350.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,42F0T@68295|Thermoanaerobacterales	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
TLS2_k127_1091858_5	1047013.AQSP01000057_gene1926	4.827e-64	236.0	COG1253@1|root,COG1253@2|Bacteria,2NP9I@2323|unclassified Bacteria	2|Bacteria	S	Transporter associated domain	gldE	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_1091858_7	240015.ACP_1699	5.633e-24	107.0	COG0319@1|root,COG0319@2|Bacteria,3Y53R@57723|Acidobacteria,2JJPS@204432|Acidobacteriia	204432|Acidobacteriia	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
TLS2_k127_1091858_1	338963.Pcar_1232	2.118e-126	434.0	COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,43SCT@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	7TM-HD extracellular	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
TLS2_k127_1091858_0	234267.Acid_1167	4.723e-186	590.0	COG0304@1|root,COG0304@2|Bacteria,3Y3IS@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS2_k127_1091858_6	227377.CBU_0496	6.876e-26	108.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,1S8X4@1236|Gammaproteobacteria,1JEY0@118969|Legionellales	118969|Legionellales	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS2_k127_1091858_4	392500.Swoo_2042	2.934e-79	273.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,2Q9DM@267890|Shewanellaceae	1236|Gammaproteobacteria	IQ	PFAM short-chain dehydrogenase reductase SDR	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0030497,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iAF1260.b1093,iAPECO1_1312.APECO1_174,iBWG_1329.BWG_0941,iE2348C_1286.E2348C_1185,iEC55989_1330.EC55989_1205,iECABU_c1320.ECABU_c13060,iECDH10B_1368.ECDH10B_1165,iECDH1ME8569_1439.ECDH1ME8569_1028,iECED1_1282.ECED1_1236,iECIAI39_1322.ECIAI39_2068,iECNA114_1301.ECNA114_1150,iECO103_1326.ECO103_1138,iECOK1_1307.ECOK1_1200,iECP_1309.ECP_1085,iECS88_1305.ECS88_1107,iECSE_1348.ECSE_1157,iECSF_1327.ECSF_0992,iECUMN_1333.ECUMN_1268,iECW_1372.ECW_m1201,iEKO11_1354.EKO11_2741,iETEC_1333.ETEC_1158,iEcDH1_1363.EcDH1_2554,iEcE24377_1341.EcE24377A_1214,iEcHS_1320.EcHS_A1215,iEcSMS35_1347.EcSMS35_2034,iEcolC_1368.EcolC_2508,iG2583_1286.G2583_1353,iJN746.PP_1914,iJO1366.b1093,iJR904.b1093,iSBO_1134.SBO_1970,iSFV_1184.SFV_1113,iSF_1195.SF1097,iSFxv_1172.SFxv_1249,iSSON_1240.SSON_1113,iS_1188.S1177,iSbBS512_1146.SbBS512_E2231,iUMN146_1321.UM146_11860,iUMNK88_1353.UMNK88_1363,iUTI89_1310.UTI89_C1218,iWFL_1372.ECW_m1201,iY75_1357.Y75_RS05710	adh_short_C2
TLS2_k127_1091858_2	234267.Acid_2598	2.627e-107	355.0	COG0331@1|root,COG0331@2|Bacteria,3Y2TE@57723|Acidobacteria	57723|Acidobacteria	I	malonyl CoA-acyl carrier protein transacylase	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
TLS2_k127_1101611_1	1340493.JNIF01000003_gene4569	3.812e-105	360.0	COG3356@1|root,COG3356@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
TLS2_k127_1101611_0	1267535.KB906767_gene1681	8e-163	522.0	COG0399@1|root,COG0399@2|Bacteria,3Y7K8@57723|Acidobacteria,2JK8Z@204432|Acidobacteriia	57723|Acidobacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_1111906_0	1047013.AQSP01000140_gene2471	1.085e-127	421.0	COG0206@1|root,COG0206@2|Bacteria,2NNSU@2323|unclassified Bacteria	2|Bacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS2_k127_1111906_1	861299.J421_0797	3.349e-13	79.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	dgkA	-	2.7.1.107,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27	ko:K00901,ko:K01096,ko:K19302	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02029,R02240,R05627	RC00002,RC00017	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_2369	DAGK_prokar,PAP2,PAP2_3
TLS2_k127_1111906_3	426355.Mrad2831_4912	0.0001136	53.0	COG2890@1|root,COG2890@2|Bacteria,1R6XD@1224|Proteobacteria,2U1R8@28211|Alphaproteobacteria,1JRWW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	PFAM methyltransferase small	-	-	-	-	-	-	-	-	-	-	-	-	MTS
TLS2_k127_1113191_0	1047013.AQSP01000110_gene56	4.734e-126	432.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_1113191_1	1540221.JQNI01000001_gene474	6.832e-49	181.0	COG1878@1|root,COG1878@2|Bacteria,1WJZU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation	kynB	GO:0003674,GO:0003824,GO:0004061,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
TLS2_k127_1113191_2	1089547.KB913013_gene977	1.069e-48	177.0	COG4225@1|root,COG4225@2|Bacteria,4NJYK@976|Bacteroidetes,47MFS@768503|Cytophagia	976|Bacteroidetes	S	Glycosyl Hydrolase Family 88	-	-	3.2.1.180	ko:K18581	-	-	R10867	RC00049,RC02427	ko00000,ko01000	-	GH88	-	Glyco_hydro_88
TLS2_k127_1124438_0	330214.NIDE4254	1.386e-115	374.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_1124438_1	1121405.dsmv_1033	5.373e-80	273.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,42QRC@68525|delta/epsilon subdivisions,2WMP7@28221|Deltaproteobacteria,2MHMA@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
TLS2_k127_1127965_2	298386.PBPRA1421	1.095e-33	132.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1NR3M@1224|Proteobacteria,1T1WT@1236|Gammaproteobacteria,1XSS8@135623|Vibrionales	135623|Vibrionales	P	NAD(FAD)-dependent dehydrogenases	cdr	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
TLS2_k127_1127965_3	530564.Psta_3643	1.188e-31	128.0	2C85M@1|root,32UAW@2|Bacteria,2J0CM@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Stress responsive A B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
TLS2_k127_1127965_0	1340493.JNIF01000003_gene4558	2.056e-87	296.0	COG1082@1|root,COG1082@2|Bacteria,3Y3CH@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_1127965_1	926550.CLDAP_29740	3.33e-69	248.0	COG1940@1|root,COG1940@2|Bacteria,2G6I0@200795|Chloroflexi	200795|Chloroflexi	GK	PFAM ROK family protein	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_1127965_4	367299.JOEE01000008_gene524	5.899e-05	51.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,4FFN3@85021|Intrasporangiaceae	201174|Actinobacteria	M	lipid A biosynthesis acyltransferase	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
TLS2_k127_1149308_1	29581.BW37_01876	4.481e-60	219.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2VJ80@28216|Betaproteobacteria,4751W@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Type II secretion system (T2SS), protein F	tadB	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_1149308_0	391038.Bphy_5324	8.175e-166	531.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2VJWJ@28216|Betaproteobacteria,1K2AA@119060|Burkholderiaceae	28216|Betaproteobacteria	U	type II secretion system protein E	cpaF1	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS2_k127_1149308_2	243090.RB5175	1.043e-36	153.0	COG2197@1|root,COG4963@1|root,COG2197@2|Bacteria,COG4963@2|Bacteria,2IYFX@203682|Planctomycetes	203682|Planctomycetes	KTU	Flp pilus assembly protein, ATPase CpaE	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CbiA,Response_reg
TLS2_k127_1158806_1	1408473.JHXO01000010_gene3694	2.15e-06	58.0	2ET0X@1|root,33KJ5@2|Bacteria,4NZM8@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1158806_0	518766.Rmar_1280	2.185e-28	131.0	COG1520@1|root,COG2931@1|root,COG1520@2|Bacteria,COG2931@2|Bacteria,4NKF1@976|Bacteroidetes	976|Bacteroidetes	Q	A domain in the BMP inhibitor chordin and in microbial proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,SusE
TLS2_k127_1159575_1	243231.GSU0094	1.065e-117	396.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
TLS2_k127_1159575_5	1168059.KB899087_gene3133	6.874e-08	60.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3F0VP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_1159575_2	1458427.BAWN01000018_gene1142	5.068e-31	126.0	COG3744@1|root,COG3744@2|Bacteria,1N2T0@1224|Proteobacteria,2VTSR@28216|Betaproteobacteria,4AINI@80864|Comamonadaceae	28216|Betaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_1159575_3	861299.J421_1641	2.748e-17	88.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS2_k127_1159575_0	1123248.KB893381_gene956	8.491e-193	625.0	COG3345@1|root,COG3345@2|Bacteria	2|Bacteria	G	alpha-galactosidase	rafA	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
TLS2_k127_1159575_4	479434.Sthe_1981	3.508e-08	60.0	COG4758@1|root,COG4758@2|Bacteria	2|Bacteria	KT	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
TLS2_k127_116314_0	502025.Hoch_5205	4.41e-154	502.0	COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1MXA1@1224|Proteobacteria,42PXZ@68525|delta/epsilon subdivisions,2X667@28221|Deltaproteobacteria,2Z33M@29|Myxococcales	28221|Deltaproteobacteria	P	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
TLS2_k127_116314_1	517418.Ctha_0981	5.087e-77	280.0	COG4206@1|root,COG4206@2|Bacteria,1FE55@1090|Chlorobi	1090|Chlorobi	M	TonB-dependent receptor plug	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TLS2_k127_116314_2	344747.PM8797T_20783	8.96e-29	123.0	COG1082@1|root,COG1082@2|Bacteria,2IXXX@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase-like TIM barrel	-	-	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_1169207_1	504472.Slin_3008	2.092e-06	49.0	COG2333@1|root,COG2333@2|Bacteria,4NH12@976|Bacteroidetes,47NEU@768503|Cytophagia	976|Bacteroidetes	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_1169207_0	1183438.GKIL_4354	2.026e-103	355.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_1173552_4	1403819.BATR01000041_gene1221	1.319e-21	98.0	COG2333@1|root,COG2333@2|Bacteria	2|Bacteria	N	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_1173552_1	926566.Terro_3906	1.715e-92	313.0	COG1082@1|root,COG1082@2|Bacteria,3Y50A@57723|Acidobacteria,2JMI8@204432|Acidobacteriia	204432|Acidobacteriia	G	Xylose isomerase-like TIM barrel	-	-	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_1173552_3	401053.AciPR4_2554	3.783e-64	230.0	COG1127@1|root,COG1127@2|Bacteria,3Y45H@57723|Acidobacteria,2JHWI@204432|Acidobacteriia	204432|Acidobacteriia	Q	pfam abc	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TLS2_k127_1173552_2	1190603.AJYD01000039_gene2744	2.99e-64	226.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1XT5G@135623|Vibrionales	135623|Vibrionales	E	Histidine biosynthesis bifunctional protein HisIE	hisI	GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.6.1.31	ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
TLS2_k127_1173552_0	370438.PTH_2532	5.129e-104	345.0	COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,260VM@186807|Peptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05755	His_biosynth
TLS2_k127_1173552_5	926562.Oweho_3491	0.0008195	42.0	COG0106@1|root,COG0106@2|Bacteria,4NEEX@976|Bacteroidetes,1HWQ2@117743|Flavobacteriia,2PAV9@246874|Cryomorphaceae	976|Bacteroidetes	E	Histidine biosynthesis protein	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS2_k127_1177141_1	880072.Desac_2826	5.624e-76	267.0	COG3746@1|root,COG3746@2|Bacteria,1RA39@1224|Proteobacteria,42U77@68525|delta/epsilon subdivisions,2WQ4R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Phosphate-selective porin O and P	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
TLS2_k127_1177141_0	118163.Ple7327_1250	5.762e-122	400.0	COG0226@1|root,COG0226@2|Bacteria,1FZZ0@1117|Cyanobacteria,3VIGF@52604|Pleurocapsales	1117|Cyanobacteria	P	TIGRFAM phosphate binding protein	sphX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like,PBP_like_2
TLS2_k127_1177141_2	867845.KI911784_gene174	3.623e-71	247.0	COG0573@1|root,COG0573@2|Bacteria,2G62J@200795|Chloroflexi,375B0@32061|Chloroflexia	32061|Chloroflexia	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS2_k127_1184338_6	649638.Trad_1594	3.89e-07	53.0	COG3861@1|root,COG3861@2|Bacteria	2|Bacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382,Hemerythrin,PRC
TLS2_k127_1184338_0	761193.Runsl_1167	3.288e-151	492.0	COG4948@1|root,COG4948@2|Bacteria,4NE9A@976|Bacteroidetes,47NDY@768503|Cytophagia	976|Bacteroidetes	M	Mandelate racemase / muconate lactonizing enzyme, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_1184338_2	1166018.FAES_1570	4.829e-105	352.0	COG0684@1|root,COG0684@2|Bacteria,4NF3M@976|Bacteroidetes,47JU7@768503|Cytophagia	976|Bacteroidetes	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
TLS2_k127_1184338_4	234267.Acid_4419	1.459e-44	179.0	COG5616@1|root,COG5616@2|Bacteria,3Y9AR@57723|Acidobacteria	57723|Acidobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1184338_1	1132509.C447_11290	1.031e-109	379.0	COG3250@1|root,arCOG07337@2157|Archaea	2157|Archaea	G	COG3250 Beta-galactosidase beta-glucuronidase	-	-	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TLS2_k127_1184338_3	1499967.BAYZ01000184_gene4601	1.116e-72	257.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TLS2_k127_1184338_5	639030.JHVA01000001_gene590	7.611e-28	119.0	COG1629@1|root,COG4771@2|Bacteria,3Y2WI@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_1202411_2	1168034.FH5T_20035	2.781e-61	214.0	COG2502@1|root,COG2502@2|Bacteria,4NFZA@976|Bacteroidetes,2FMP0@200643|Bacteroidia	976|Bacteroidetes	E	aspartate--ammonia ligase	asnA	-	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	-	R00483	RC00010	ko00000,ko00001,ko01000	-	-	-	AsnA
TLS2_k127_1202411_0	517418.Ctha_1656	6.255e-134	428.0	COG0450@1|root,COG0450@2|Bacteria,1FDZ0@1090|Chlorobi	1090|Chlorobi	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
TLS2_k127_1202411_1	926549.KI421517_gene3299	9.456e-105	347.0	COG1874@1|root,COG1874@2|Bacteria,4NQBQ@976|Bacteroidetes,47QIS@768503|Cytophagia	976|Bacteroidetes	G	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
TLS2_k127_1214706_1	234267.Acid_1154	1.463e-86	302.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_1214706_0	1340493.JNIF01000003_gene2645	6.572e-91	335.0	COG2312@1|root,COG2312@2|Bacteria,3Y8PV@57723|Acidobacteria	57723|Acidobacteria	S	Erythromycin esterase	-	-	-	ko:K06880	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Erythro_esteras
TLS2_k127_1214706_2	1183438.GKIL_1583	5.897e-38	166.0	COG1413@1|root,COG4219@1|root,COG1413@2|Bacteria,COG4219@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,PT-HINT,Peptidase_M56,Sulfatase
TLS2_k127_1215047_1	234267.Acid_1064	2.351e-25	118.0	COG4733@1|root,COG4733@2|Bacteria,3Y53H@57723|Acidobacteria	57723|Acidobacteria	S	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1215047_0	1267535.KB906767_gene4424	6.232e-65	224.0	COG1220@1|root,COG1220@2|Bacteria,3Y2K2@57723|Acidobacteria,2JIS7@204432|Acidobacteriia	204432|Acidobacteriia	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
TLS2_k127_121758_2	1123508.JH636446_gene6238	1.921e-46	171.0	28J3W@1|root,2Z900@2|Bacteria,2IZRG@203682|Planctomycetes	203682|Planctomycetes	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
TLS2_k127_121758_5	240015.ACP_2420	2.655e-06	57.0	COG2825@1|root,COG2825@2|Bacteria,3Y4WC@57723|Acidobacteria,2JJHF@204432|Acidobacteriia	204432|Acidobacteriia	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
TLS2_k127_121758_3	1173026.Glo7428_4061	5.79e-35	138.0	COG3602@1|root,COG3602@2|Bacteria,1G83B@1117|Cyanobacteria	1117|Cyanobacteria	L	ACT domain	-	-	3.1.26.4	ko:K03469,ko:K09964	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	ACT_3,ACT_7
TLS2_k127_121758_4	368407.Memar_1051	1.917e-15	81.0	COG3187@1|root,arCOG03952@2157|Archaea,2Y55P@28890|Euryarchaeota,2NBFA@224756|Methanomicrobia	224756|Methanomicrobia	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
TLS2_k127_121758_0	880070.Cycma_3198	3.49e-120	396.0	COG1957@1|root,COG1957@2|Bacteria	2|Bacteria	F	ribosylpyrimidine nucleosidase activity	-	-	-	ko:K01250	-	-	-	-	ko00000,ko01000	-	-	-	IU_nuc_hydro
TLS2_k127_121758_1	1487953.JMKF01000020_gene2252	2.82e-70	251.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_1221083_3	926549.KI421517_gene1829	1.42e-53	193.0	COG2730@1|root,COG2730@2|Bacteria,4NF3J@976|Bacteroidetes,47M4E@768503|Cytophagia	976|Bacteroidetes	G	Putative collagen-binding domain of a collagenase	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038
TLS2_k127_1221083_0	1035308.AQYY01000001_gene2129	3.292e-200	640.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,2629F@186807|Peptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17
TLS2_k127_1221083_4	234267.Acid_1239	9.815e-50	194.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	icfG	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,GAF_2,HAMP,Response_reg,SpoIIE
TLS2_k127_1221083_1	234267.Acid_1848	3.718e-165	529.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_1221083_2	344747.PM8797T_00507	2.803e-115	377.0	COG1413@1|root,COG3119@1|root,COG1413@2|Bacteria,COG3119@2|Bacteria,2IYFZ@203682|Planctomycetes	203682|Planctomycetes	CP	COG3119 Arylsulfatase A	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
TLS2_k127_1223127_0	234267.Acid_5336	1.687e-104	372.0	COG0642@1|root,COG0784@1|root,COG3292@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,3Y3IC@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
TLS2_k127_1223127_3	379066.GAU_3239	5.85e-41	175.0	COG0840@1|root,COG2972@1|root,COG0840@2|Bacteria,COG2972@2|Bacteria,1ZUEF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
TLS2_k127_1223127_1	880073.Calab_1912	2.305e-76	263.0	COG2518@1|root,COG2518@2|Bacteria,2NP7E@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
TLS2_k127_1223127_2	335543.Sfum_2471	7.469e-55	204.0	COG1032@1|root,COG1032@2|Bacteria,1R4XI@1224|Proteobacteria,42NPM@68525|delta/epsilon subdivisions,2WJK2@28221|Deltaproteobacteria,2MQ6Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
TLS2_k127_1226925_1	3988.XP_002540391.1	5.46e-38	157.0	COG4564@1|root,2SYWY@2759|Eukaryota	2759|Eukaryota	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_1226925_0	1267535.KB906767_gene1250	0.0	1102.0	COG0587@1|root,COG0587@2|Bacteria,3Y3YK@57723|Acidobacteria,2JKQG@204432|Acidobacteriia	204432|Acidobacteriia	L	Belongs to the DNA polymerase type-C family. DnaE2 subfamily	-	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS2_k127_1226925_2	1340493.JNIF01000003_gene4542	4.466e-31	126.0	COG0389@1|root,COG0389@2|Bacteria,3Y3EV@57723|Acidobacteria	57723|Acidobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
TLS2_k127_123986_2	118163.Ple7327_0990	6.9e-10	72.0	COG1807@1|root,COG1807@2|Bacteria,1G0W2@1117|Cyanobacteria	1117|Cyanobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_123986_0	1232410.KI421412_gene247	2.306e-127	416.0	COG0535@1|root,COG0535@2|Bacteria,1RADC@1224|Proteobacteria,42RDA@68525|delta/epsilon subdivisions,2WN4I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
TLS2_k127_123986_1	1232410.KI421412_gene282	4.045e-26	108.0	COG1287@1|root,COG1287@2|Bacteria,1R8YG@1224|Proteobacteria,43BIB@68525|delta/epsilon subdivisions,2WMI5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Oligosaccharyl transferase STT3 subunit	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
TLS2_k127_125616_1	398767.Glov_2829	7.475e-135	431.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,43TCM@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TLS2_k127_125616_2	338966.Ppro_1405	3.585e-67	233.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,42TM2@68525|delta/epsilon subdivisions,2WQ0U@28221|Deltaproteobacteria,43UPB@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS2_k127_125616_0	338966.Ppro_1406	1.025e-161	514.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,42MTI@68525|delta/epsilon subdivisions,2WIXW@28221|Deltaproteobacteria,43TH8@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
TLS2_k127_1264414_0	298653.Franean1_5035	3.551e-11	77.0	COG2351@1|root,COG2351@2|Bacteria,2H2SD@201174|Actinobacteria	201174|Actinobacteria	M	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,VRP1
TLS2_k127_1275701_0	1047013.AQSP01000130_gene1875	1.391e-112	370.0	COG0034@1|root,COG0034@2|Bacteria,2NNSY@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
TLS2_k127_1275701_1	1304885.AUEY01000017_gene3712	5.051e-18	90.0	COG1321@1|root,COG1321@2|Bacteria,1RH2Z@1224|Proteobacteria,42U02@68525|delta/epsilon subdivisions,2X6HI@28221|Deltaproteobacteria,2MQ1G@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
TLS2_k127_1275701_2	682795.AciX8_3589	1.699e-06	55.0	COG1629@1|root,COG4771@2|Bacteria,3Y3HY@57723|Acidobacteria,2JIYZ@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_1277666_0	234267.Acid_1455	1.075e-100	350.0	COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,3Y46R@57723|Acidobacteria	57723|Acidobacteria	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PDZ_2,Peptidase_M28
TLS2_k127_1277666_1	234267.Acid_0133	4.24e-44	165.0	COG1607@1|root,COG1607@2|Bacteria	2|Bacteria	I	acyl-coa hydrolase	ykhA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	3.1.2.20	ko:K01073	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
TLS2_k127_1277666_2	234267.Acid_7775	1.829e-29	125.0	COG1595@1|root,COG1595@2|Bacteria,3Y7WY@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_128413_2	883080.HMPREF9697_01910	3.737e-05	50.0	2DEWB@1|root,2ZPI4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_128413_0	644282.Deba_3078	1.317e-126	414.0	COG0500@1|root,COG2226@2|Bacteria,1QYJ7@1224|Proteobacteria,43CSU@68525|delta/epsilon subdivisions	1224|Proteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
TLS2_k127_128413_1	1267534.KB906754_gene2643	7.161e-75	258.0	COG0606@1|root,COG0606@2|Bacteria,3Y3JA@57723|Acidobacteria,2JI3F@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
TLS2_k127_1285705_6	1894.JOER01000002_gene3586	1.293e-06	61.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TLS2_k127_1285705_1	247490.KSU1_B0365	1.836e-133	439.0	COG2204@1|root,COG2204@2|Bacteria,2IXIQ@203682|Planctomycetes	203682|Planctomycetes	T	Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_1285705_4	1408428.JNJP01000045_gene1976	2.762e-34	151.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,2M8UQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_3_2
TLS2_k127_1285705_0	945713.IALB_1137	7.502e-170	550.0	COG1574@1|root,COG1574@2|Bacteria	2|Bacteria	G	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_1285705_2	211165.AJLN01000100_gene4254	4.823e-72	249.0	COG1670@1|root,COG1670@2|Bacteria,1GHZ7@1117|Cyanobacteria,1JJ64@1189|Stigonemataceae	1117|Cyanobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_1285705_5	1329516.JPST01000015_gene779	3.563e-34	140.0	COG2076@1|root,COG2076@2|Bacteria,1VEZX@1239|Firmicutes,4I6KX@91061|Bacilli,27D2S@186824|Thermoactinomycetaceae	91061|Bacilli	P	Small Multidrug Resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Multi_Drug_Res
TLS2_k127_1285705_3	1121396.KB893123_gene1085	7.179e-68	247.0	COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,1NQTI@1224|Proteobacteria,43C0D@68525|delta/epsilon subdivisions,2WIYN@28221|Deltaproteobacteria,2MHY4@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80,3.1.1.61	ko:K00575,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,PAS_10,PAS_4
TLS2_k127_128751_0	240016.ABIZ01000001_gene2673	5.046e-99	346.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,46U7Q@74201|Verrucomicrobia,2ITXJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	NAD synthase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase,NAD_synthase
TLS2_k127_128751_1	1232410.KI421428_gene1074	9.957e-46	170.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,42TV9@68525|delta/epsilon subdivisions,2WNAN@28221|Deltaproteobacteria,43SIE@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_1293745_8	32057.KB217478_gene4507	4.549e-10	63.0	COG2971@1|root,COG2971@2|Bacteria,1G3SA@1117|Cyanobacteria,1HKDJ@1161|Nostocales	1117|Cyanobacteria	G	PFAM BadF BadG BcrA BcrD ATPase family	-	-	2.7.1.59	ko:K00884,ko:K02616	ko00520,ko01100,map00520,map01100	-	R01201	RC00002,RC00017	ko00000,ko00001,ko01000,ko03000	-	-	-	BcrAD_BadFG
TLS2_k127_1293745_2	234267.Acid_4784	2.18e-132	437.0	COG0591@1|root,COG0591@2|Bacteria,3Y419@57723|Acidobacteria	57723|Acidobacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_1293745_6	234267.Acid_7948	3.266e-28	122.0	2E6AH@1|root,330YD@2|Bacteria,3Y8MQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1293745_5	234267.Acid_2426	6.622e-59	212.0	COG5588@1|root,COG5588@2|Bacteria,3Y7RN@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
TLS2_k127_1293745_3	234267.Acid_2421	2.065e-111	371.0	COG1319@1|root,COG1319@2|Bacteria,3Y3NU@57723|Acidobacteria	57723|Acidobacteria	C	PFAM molybdopterin dehydrogenase, FAD-binding	-	-	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_1293745_0	204669.Acid345_0762	1.198e-261	824.0	COG1529@1|root,COG1529@2|Bacteria,3Y2ME@57723|Acidobacteria,2JIZI@204432|Acidobacteriia	204432|Acidobacteriia	C	aldehyde oxidase and xanthine dehydrogenase a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_1293745_4	204669.Acid345_0761	2.247e-59	214.0	COG2080@1|root,COG2080@2|Bacteria,3Y4DP@57723|Acidobacteria,2JJ2F@204432|Acidobacteriia	204432|Acidobacteriia	C	2Fe-2S -binding	-	-	-	ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002	-	-	-	Fer2,Fer2_2,TAT_signal
TLS2_k127_1293745_7	312153.Pnuc_0383	4.222e-24	106.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2VSJ0@28216|Betaproteobacteria,1K7UM@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4,Fer4_4
TLS2_k127_1293745_1	1232410.KI421415_gene3020	2.536e-174	562.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,43THJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
TLS2_k127_129529_0	880073.Calab_1114	2.73e-143	466.0	COG0733@1|root,COG0733@2|Bacteria,2NNP4@2323|unclassified Bacteria	2|Bacteria	S	Sodium:neurotransmitter symporter family	yocR	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
TLS2_k127_129529_1	935948.KE386493_gene2380	2.14e-95	323.0	COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24FCZ@186801|Clostridia,42HY1@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS2_k127_1297789_1	234267.Acid_3246	5.218e-115	377.0	COG0673@1|root,COG0673@2|Bacteria,3Y76D@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_1297789_2	886293.Sinac_1624	2.786e-86	295.0	COG0546@1|root,COG0546@2|Bacteria,2IYT6@203682|Planctomycetes	203682|Planctomycetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS2_k127_1297789_0	452637.Oter_0119	2.727e-156	500.0	COG2730@1|root,COG2730@2|Bacteria,46US1@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
TLS2_k127_1297789_3	1340493.JNIF01000003_gene4258	1.769e-36	157.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_1297789_4	224325.AF_0616	1.579e-24	115.0	COG1807@1|root,arCOG00566@2157|Archaea	2157|Archaea	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_22,PMT_2
TLS2_k127_129954_1	518766.Rmar_0611	5.815e-40	151.0	COG1376@1|root,COG1376@2|Bacteria,4P35B@976|Bacteroidetes	976|Bacteroidetes	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS2_k127_129954_0	289376.THEYE_A1801	2.018e-97	334.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_1304221_1	335543.Sfum_2411	2.637e-91	316.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MR9A@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_1304221_0	479434.Sthe_2480	6.198e-168	550.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
TLS2_k127_1310859_4	1185876.BN8_06021	1.302e-06	55.0	COG5434@1|root,COG5434@2|Bacteria,4NID5@976|Bacteroidetes,47S55@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28
TLS2_k127_1310859_0	1242864.D187_004920	1.428e-239	749.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
TLS2_k127_1310859_3	644282.Deba_1149	4.802e-16	90.0	2BCS0@1|root,303C3@2|Bacteria,1N7SU@1224|Proteobacteria,42WF2@68525|delta/epsilon subdivisions,2WR6I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
TLS2_k127_1310859_2	1123393.KB891317_gene2315	3.12e-41	162.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,1KT59@119069|Hydrogenophilales	119069|Hydrogenophilales	K	Nitrogen regulatory protein P-II	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
TLS2_k127_1310859_1	1125863.JAFN01000001_gene3500	2.635e-43	175.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
TLS2_k127_1311198_0	1304880.JAGB01000002_gene2198	1.51e-53	199.0	COG1874@1|root,COG1874@2|Bacteria,1TT9J@1239|Firmicutes,24CY9@186801|Clostridia	186801|Clostridia	G	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
TLS2_k127_1311198_1	880070.Cycma_1902	1.485e-40	169.0	28MHM@1|root,2ZAUH@2|Bacteria,4NKMG@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1320037_2	1120973.AQXL01000129_gene2446	1.144e-79	273.0	COG1028@1|root,COG1028@2|Bacteria,1TRVE@1239|Firmicutes,4HCFY@91061|Bacilli,27AT7@186823|Alicyclobacillaceae	91061|Bacilli	IQ	KR domain	fabL	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.104	ko:K10780	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R01404,R04430,R04725,R04956,R04959,R04962,R04967,R04970	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_1320037_3	469383.Cwoe_0109	2.448e-22	106.0	COG1802@1|root,COG1802@2|Bacteria,2GMJX@201174|Actinobacteria	201174|Actinobacteria	K	gntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_1320037_1	234267.Acid_5045	3.542e-107	355.0	COG1082@1|root,COG1082@2|Bacteria,3Y61S@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_1320037_0	1123508.JH636445_gene6648	7.1e-162	516.0	COG1680@1|root,COG1680@2|Bacteria,2IWSV@203682|Planctomycetes	203682|Planctomycetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_1330221_0	1122137.AQXF01000003_gene1948	4.022e-122	415.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TRI9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	exporters of the RND superfamily	MA20_16090	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_1330221_1	1162668.LFE_0460	4.435e-48	177.0	COG1403@1|root,COG1403@2|Bacteria,3J0VM@40117|Nitrospirae	40117|Nitrospirae	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
TLS2_k127_134640_2	1192034.CAP_0501	5.823e-20	98.0	COG3386@1|root,COG3386@2|Bacteria,1QYGK@1224|Proteobacteria,437EJ@68525|delta/epsilon subdivisions,2X2KV@28221|Deltaproteobacteria,2Z04K@29|Myxococcales	28221|Deltaproteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_134640_0	1047013.AQSP01000130_gene1860	4.291e-282	878.0	COG0405@1|root,COG0405@2|Bacteria,2NQK8@2323|unclassified Bacteria	2|Bacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_134640_1	1267533.KB906739_gene2717	1.489e-168	544.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid_C,Bgal_small_N,Glyco_hydro_2,Glyco_hydro_28,Glyco_hydro_2_C,Glyco_hydro_2_N,fn3
TLS2_k127_1358436_0	1267535.KB906767_gene1026	1.29e-86	304.0	COG0673@1|root,COG0673@2|Bacteria,3Y6VS@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_1358436_1	1356852.N008_19870	9.968e-05	53.0	COG1629@1|root,COG4771@2|Bacteria,4NEIG@976|Bacteroidetes,47JGS@768503|Cytophagia	976|Bacteroidetes	P	TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug
TLS2_k127_137268_3	742735.HMPREF9467_01451	6.683e-17	83.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,21YG8@1506553|Lachnoclostridium	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TLS2_k127_137268_1	1158338.JNLJ01000005_gene1766	4.759e-48	182.0	COG0134@1|root,COG0134@2|Bacteria,2G3YD@200783|Aquificae	200783|Aquificae	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
TLS2_k127_137268_2	1340493.JNIF01000003_gene4662	2.209e-30	127.0	COG0135@1|root,COG0135@2|Bacteria,3Y50K@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
TLS2_k127_137268_0	1121468.AUBR01000014_gene2228	7.165e-130	420.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia,42EWK@68295|Thermoanaerobacterales	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_1394567_3	1355368.JART01000002_gene2360	6.78e-13	70.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,42M2H@68525|delta/epsilon subdivisions,2YMM9@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_1394567_1	1047013.AQSP01000034_gene1652	7.063e-122	409.0	COG0342@1|root,COG0342@2|Bacteria,2NNNU@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_1394567_2	1499967.BAYZ01000074_gene2162	3.473e-20	93.0	COG1862@1|root,COG1862@2|Bacteria,2NPY3@2323|unclassified Bacteria	2|Bacteria	U	Preprotein translocase, YajC	yajC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TLS2_k127_1394567_0	243231.GSU2619	7.296e-133	433.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,43TNC@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
TLS2_k127_1396232_8	671143.DAMO_3023	3.807e-23	105.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0005575,GO:0005576	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_1396232_11	867903.ThesuDRAFT_00805	7.676e-13	70.0	COG3526@1|root,COG3526@2|Bacteria,1VKFI@1239|Firmicutes,24VMR@186801|Clostridia	186801|Clostridia	O	selT selW selH selenoprotein	-	-	-	ko:K07401	-	-	-	-	ko00000	-	-	-	Rdx
TLS2_k127_1396232_1	518766.Rmar_0638	3.993e-275	854.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1FIMH@1100069|Bacteroidetes Order II. Incertae sedis	2|Bacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_1396232_10	518766.Rmar_0637	6.06e-19	90.0	2FDJV@1|root,345M5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1396232_9	234267.Acid_4150	9.71e-21	95.0	COG0607@1|root,32YCZ@2|Bacteria,3Y5Z1@57723|Acidobacteria	57723|Acidobacteria	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
TLS2_k127_1396232_0	177437.HRM2_47440	0.0	1326.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,2MIUG@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TLS2_k127_1396232_5	671143.DAMO_1932	8.968e-82	287.0	COG0845@1|root,COG0845@2|Bacteria,2NPS3@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
TLS2_k127_1396232_6	234267.Acid_4153	5.184e-52	201.0	COG1538@1|root,COG1538@2|Bacteria,3Y5F3@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS2_k127_1396232_7	452637.Oter_1468	9.99e-34	133.0	COG0640@1|root,COG0640@2|Bacteria,46WX7@74201|Verrucomicrobia	2|Bacteria	K	PFAM regulatory protein ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS2_k127_1396232_2	234267.Acid_0457	4.743e-123	406.0	COG0348@1|root,COG0348@2|Bacteria,3Y3H4@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
TLS2_k127_1396232_3	264732.Moth_0582	1.37e-103	349.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,42F9T@68295|Thermoanaerobacterales	186801|Clostridia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
TLS2_k127_1396232_4	1303518.CCALI_00333	7.807e-92	306.0	COG0481@1|root,COG0481@2|Bacteria	2|Bacteria	M	GTPase activity	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
TLS2_k127_1412927_2	313624.NSP_23150	2.87e-67	236.0	COG0438@1|root,COG0438@2|Bacteria,1G2XD@1117|Cyanobacteria,1HPC2@1161|Nostocales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_1412927_4	1449065.JMLL01000010_gene863	1.815e-32	142.0	28KF0@1|root,2ZA18@2|Bacteria,1R7MD@1224|Proteobacteria,2U08E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1412927_1	717785.HYPMC_3134	9.008e-90	309.0	COG0438@1|root,COG0438@2|Bacteria,1MWEM@1224|Proteobacteria,2U1NW@28211|Alphaproteobacteria,3N8M7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_1412927_3	324925.Ppha_0562	3.733e-64	226.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	wcaF	-	2.3.1.79	ko:K00661,ko:K03818	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
TLS2_k127_1412927_0	1410620.SHLA_22c000650	2.286e-93	314.0	COG0463@1|root,COG0463@2|Bacteria,1RE4C@1224|Proteobacteria,2U3U9@28211|Alphaproteobacteria,4B85C@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family 2	lpsC	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_1431555_3	247490.KSU1_D0810	0.0008582	48.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Arm-DNA-bind_3,Phage_int_SAM_1,Phage_integrase
TLS2_k127_1431555_0	56780.SYN_01126	3.78e-21	108.0	COG3204@1|root,COG3204@2|Bacteria,1QVA9@1224|Proteobacteria	1224|Proteobacteria	L	pilus organization	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1431555_1	1121935.AQXX01000072_gene3	2.916e-20	96.0	COG1572@1|root,COG2304@1|root,COG3209@1|root,COG1572@2|Bacteria,COG2304@2|Bacteria,COG3209@2|Bacteria,1QU09@1224|Proteobacteria,1T39R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat
TLS2_k127_1431555_2	344747.PM8797T_02424	1.251e-09	68.0	COG1404@1|root,COG2931@1|root,COG3209@1|root,COG3210@1|root,COG4932@1|root,COG5276@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	M	domain protein	-	-	3.2.1.4,3.4.21.62,3.4.24.40	ko:K01179,ko:K01342,ko:K01406,ko:K07004,ko:K12287,ko:K14194,ko:K15125,ko:K20276	ko00500,ko01100,ko01503,ko02024,ko05133,ko05150,map00500,map01100,map01503,map02024,map05133,map05150	-	R06200,R11307,R11308	-	ko00000,ko00001,ko00536,ko01000,ko01002,ko02044,ko03110	-	GH5,GH9	-	Calx-beta,Exo_endo_phos,HemolysinCabind,VCBS
TLS2_k127_1433070_1	344747.PM8797T_19081	2.274e-42	158.0	COG0855@1|root,COG0855@2|Bacteria,2IWVK@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
TLS2_k127_1433070_0	794903.OPIT5_18925	7.251e-166	537.0	2DHIW@1|root,2ZZZR@2|Bacteria,46WA6@74201|Verrucomicrobia	794903.OPIT5_18925|-	S	Heparinase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1447681_1	926550.CLDAP_36340	1.369e-99	332.0	COG2605@1|root,COG2605@2|Bacteria,2G5TF@200795|Chloroflexi	200795|Chloroflexi	S	PFAM GHMP kinase	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_1447681_0	926569.ANT_15830	1.822e-112	371.0	COG1087@1|root,COG1087@2|Bacteria,2GA96@200795|Chloroflexi	200795|Chloroflexi	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS2_k127_1447681_2	240015.ACP_0825	2.358e-34	145.0	COG1596@1|root,COG1596@2|Bacteria,3Y7QA@57723|Acidobacteria,2JMWD@204432|Acidobacteriia	204432|Acidobacteriia	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
TLS2_k127_1447681_3	1123070.KB899258_gene1892	3.318e-17	92.0	COG1596@1|root,COG1596@2|Bacteria,46XCW@74201|Verrucomicrobia,2IVGU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Polysaccharide biosynthesis/export protein	-	-	-	-	-	-	-	-	-	-	-	-	Poly_export,SLBB
TLS2_k127_145005_0	1267535.KB906767_gene3320	1.114e-279	876.0	COG4993@1|root,COG4993@2|Bacteria,3Y639@57723|Acidobacteria	57723|Acidobacteria	G	PQQ enzyme repeat	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ
TLS2_k127_145005_1	1192034.CAP_0501	1.129e-37	148.0	COG3386@1|root,COG3386@2|Bacteria,1QYGK@1224|Proteobacteria,437EJ@68525|delta/epsilon subdivisions,2X2KV@28221|Deltaproteobacteria,2Z04K@29|Myxococcales	28221|Deltaproteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1463975_4	1121861.KB899928_gene1449	1.64e-54	202.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JQAD@204441|Rhodospirillales	204441|Rhodospirillales	E	TOBE domain	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
TLS2_k127_1463975_5	247490.KSU1_D0717	4.325e-32	130.0	COG1959@1|root,COG1959@2|Bacteria,2J0DH@203682|Planctomycetes	203682|Planctomycetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TLS2_k127_1463975_0	1128421.JAGA01000001_gene2450	2.333e-120	399.0	COG1613@1|root,COG1613@2|Bacteria,2NQGY@2323|unclassified Bacteria	2|Bacteria	P	Bacterial extracellular solute-binding protein	subI	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	iJN678.sbpA	SBP_bac_11
TLS2_k127_1463975_2	330214.NIDE1622	1.468e-78	272.0	COG0555@1|root,COG0555@2|Bacteria	2|Bacteria	P	ATPase-coupled sulfate transmembrane transporter activity	cysT	-	-	ko:K02018,ko:K02046	ko00920,ko02010,map00920,map02010	M00185,M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.8	-	-	BPD_transp_1
TLS2_k127_1463975_3	316274.Haur_0257	3.658e-78	271.0	COG4208@1|root,COG4208@2|Bacteria	2|Bacteria	P	ATPase-coupled sulfate transmembrane transporter activity	cysW	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02046,ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	iPC815.YPO3013	BPD_transp_1
TLS2_k127_1463975_1	1128421.JAGA01000001_gene2449	1.374e-91	307.0	COG3842@1|root,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran,TOBE_2,TOBE_3
TLS2_k127_1486582_1	1121468.AUBR01000006_gene356	9.39e-65	231.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,42EWY@68295|Thermoanaerobacterales	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
TLS2_k127_1486582_6	903818.KI912269_gene110	6.406e-30	124.0	COG2001@1|root,COG2001@2|Bacteria,3Y4NF@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
TLS2_k127_1486582_3	1278073.MYSTI_07636	1.486e-38	152.0	COG3386@1|root,COG3386@2|Bacteria,1NFEJ@1224|Proteobacteria,43BX0@68525|delta/epsilon subdivisions,2X77S@28221|Deltaproteobacteria,2YVY8@29|Myxococcales	28221|Deltaproteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1486582_7	309799.DICTH_0754	6.073e-10	68.0	2EGFY@1|root,33A7X@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1486582_4	266117.Rxyl_2043	8.749e-38	147.0	COG2154@1|root,COG2154@2|Bacteria,2HPFQ@201174|Actinobacteria,4CQU3@84995|Rubrobacteria	84995|Rubrobacteria	H	Transcriptional coactivator pterin dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
TLS2_k127_1486582_0	1267535.KB906767_gene4766	1.179e-276	865.0	COG1964@1|root,COG1964@2|Bacteria,3Y2WC@57723|Acidobacteria,2JHTH@204432|Acidobacteriia	204432|Acidobacteriia	S	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
TLS2_k127_1486582_2	671143.DAMO_0398	1.307e-44	169.0	COG0316@1|root,COG0694@1|root,COG0316@2|Bacteria,COG0694@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	iscA	-	-	ko:K07400,ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn,Nfu_N,NifU
TLS2_k127_1486582_8	243365.CV_1275	1.39e-09	70.0	COG0834@1|root,COG0834@2|Bacteria,1MVT6@1224|Proteobacteria,2VK4N@28216|Betaproteobacteria,2KTRB@206351|Neisseriales	206351|Neisseriales	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
TLS2_k127_1486582_5	278963.ATWD01000001_gene2597	5.997e-37	148.0	COG1595@1|root,COG1595@2|Bacteria,3Y4IW@57723|Acidobacteria,2JJ89@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_1486582_9	290397.Adeh_0231	1.725e-05	53.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	zf-HC2
TLS2_k127_149005_4	1128421.JAGA01000003_gene2872	1.611e-69	239.0	COG2010@1|root,COG2010@2|Bacteria,2NPSE@2323|unclassified Bacteria	2|Bacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
TLS2_k127_149005_1	1128421.JAGA01000003_gene2871	3.678e-216	679.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	nrfD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
TLS2_k127_149005_0	1128421.JAGA01000003_gene2870	0.0	1147.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hmeA	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molydop_binding
TLS2_k127_149005_3	886293.Sinac_3667	1.351e-86	291.0	COG3880@1|root,COG3880@2|Bacteria,2IYYJ@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
TLS2_k127_149005_6	589865.DaAHT2_2449	6.294e-61	221.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,42N0I@68525|delta/epsilon subdivisions,2WMUX@28221|Deltaproteobacteria,2MJHY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
TLS2_k127_149005_8	1341695.BBOMB_1312	8.517e-16	81.0	COG1254@1|root,COG1254@2|Bacteria,2HZRI@201174|Actinobacteria,4D1EM@85004|Bifidobacteriales	201174|Actinobacteria	C	Acylphosphatase	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
TLS2_k127_149005_5	240015.ACP_2871	7.742e-68	234.0	COG0503@1|root,COG0503@2|Bacteria,3Y30R@57723|Acidobacteria,2JHP2@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
TLS2_k127_149005_10	518766.Rmar_1798	0.0001342	53.0	COG1729@1|root,COG1729@2|Bacteria,4NEM2@976|Bacteroidetes,1FJFK@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_21,TPR_6,TPR_7,TPR_8
TLS2_k127_149005_2	204669.Acid345_4602	1.555e-118	392.0	COG0232@1|root,COG0232@2|Bacteria,3Y2S2@57723|Acidobacteria,2JIHE@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the dGTPase family. Type 2 subfamily	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
TLS2_k127_149005_7	289376.THEYE_A1480	2.023e-29	123.0	COG1399@1|root,COG1399@2|Bacteria,3J0UQ@40117|Nitrospirae	40117|Nitrospirae	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
TLS2_k127_1494106_1	1123277.KB893206_gene3445	5.742e-30	128.0	COG3525@1|root,COG3525@2|Bacteria,4NH5U@976|Bacteroidetes	976|Bacteroidetes	G	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_20b
TLS2_k127_1494106_0	204669.Acid345_0365	3.802e-57	207.0	COG2846@1|root,COG2846@2|Bacteria,3Y4SU@57723|Acidobacteria,2JMU3@204432|Acidobacteriia	204432|Acidobacteriia	D	Domain of Unknown function (DUF542)	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
TLS2_k127_1494106_2	32057.KB217478_gene1538	0.00055	46.0	COG3549@1|root,COG3549@2|Bacteria,1GPIJ@1117|Cyanobacteria,1HPXK@1161|Nostocales	1117|Cyanobacteria	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
TLS2_k127_1498976_0	1267533.KB906741_gene515	9.967e-202	642.0	COG0568@1|root,COG0568@2|Bacteria,3Y2XG@57723|Acidobacteria,2JHX1@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_1498976_2	234267.Acid_0817	7.212e-31	132.0	COG1579@1|root,COG1579@2|Bacteria,3Y509@57723|Acidobacteria	57723|Acidobacteria	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
TLS2_k127_1498976_4	595494.Tola_2509	1.766e-09	68.0	28RCN@1|root,2ZDS1@2|Bacteria,1NGBU@1224|Proteobacteria,1SUS9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1189
TLS2_k127_1498976_1	1267535.KB906767_gene1297	1.046e-41	165.0	COG2304@1|root,COG2304@2|Bacteria,3Y2PC@57723|Acidobacteria,2JI8N@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_1498976_3	525897.Dbac_0762	4.046e-16	78.0	COG0739@1|root,COG0739@2|Bacteria,1NESH@1224|Proteobacteria,42MGB@68525|delta/epsilon subdivisions,2WJ7F@28221|Deltaproteobacteria,2M7ZK@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_1501593_1	1211035.CD30_01975	8.841e-37	147.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,3IXKG@400634|Lysinibacillus	91061|Bacilli	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TLS2_k127_1501593_2	866776.HMPREF9321_0129	1.631e-13	79.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H2BH@909932|Negativicutes	909932|Negativicutes	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_1501593_0	1089553.Tph_c14270	1.51e-59	222.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,42EKD@68295|Thermoanaerobacterales	186801|Clostridia	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
TLS2_k127_1501593_3	1234409.C683_0160	9.289e-10	61.0	COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,4HART@91061|Bacilli,4AZB6@81852|Enterococcaceae	91061|Bacilli	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS06010	Formyl_trans_C,Formyl_trans_N
TLS2_k127_1505339_2	1385935.N836_20050	7.116e-49	186.0	COG1233@1|root,COG1233@2|Bacteria,1GCDS@1117|Cyanobacteria	1117|Cyanobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS2_k127_1505339_1	1123023.JIAI01000032_gene4171	7.379e-99	333.0	COG1233@1|root,COG1233@2|Bacteria,2I9K8@201174|Actinobacteria,4E2C6@85010|Pseudonocardiales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS2_k127_1505339_0	583355.Caka_0527	3.7e-116	385.0	COG1649@1|root,COG1649@2|Bacteria	2|Bacteria	F	PFAM Uncharacterised BCR, COG1649	-	-	3.2.1.11,3.2.1.18,3.2.1.35,4.2.2.23	ko:K01186,ko:K01197,ko:K05988,ko:K11931,ko:K18197	ko00500,ko00511,ko00531,ko00600,ko01100,ko02026,ko04142,map00500,map00511,map00531,map00600,map01100,map02026,map04142	M00076,M00077	R04018,R07824,R07825,R10905,R11309	RC00028,RC00077	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042	-	GH33,GH66,PL11	-	DUF1349,GHL10,Glyco_hydro_20b,Laminin_G_3,NAGidase,fn3
TLS2_k127_151296_5	344747.PM8797T_06747	1.339e-20	92.0	COG1225@1|root,COG1225@2|Bacteria,2IZIQ@203682|Planctomycetes	203682|Planctomycetes	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS2_k127_151296_4	525903.Taci_0155	7.356e-21	107.0	COG1409@1|root,COG1409@2|Bacteria,3TBDZ@508458|Synergistetes	508458|Synergistetes	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS2_k127_151296_0	1150474.JQJI01000005_gene316	1.766e-90	306.0	COG1830@1|root,COG1830@2|Bacteria,2GDV4@200918|Thermotogae	200918|Thermotogae	G	DeoC/LacD family aldolase	-	-	-	-	-	-	-	-	-	-	-	-	DeoC
TLS2_k127_151296_2	1134474.O59_002141	5.461e-64	233.0	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,1RN2K@1236|Gammaproteobacteria,1FFWC@10|Cellvibrio	1236|Gammaproteobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_151296_1	234267.Acid_6968	4.142e-64	226.0	COG5012@1|root,COG5012@2|Bacteria,3Y88D@57723|Acidobacteria	57723|Acidobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
TLS2_k127_151296_3	935948.KE386494_gene961	1.342e-29	123.0	arCOG03330@1|root,2Z82Q@2|Bacteria,1U584@1239|Firmicutes,24B07@186801|Clostridia,42FIS@68295|Thermoanaerobacterales	186801|Clostridia	H	Methanol-cobalamin methyltransferase B subunit	-	-	2.1.1.90	ko:K04480	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00356	R04384,R09098	RC00035,RC01144,RC01145,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	MtaB
TLS2_k127_1514282_3	760192.Halhy_0976	2.249e-28	116.0	COG0346@1|root,COG0346@2|Bacteria,4P4RR@976|Bacteroidetes	976|Bacteroidetes	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_1514282_5	290397.Adeh_2899	1.621e-14	87.0	COG0823@1|root,COG0823@2|Bacteria,1NKG5@1224|Proteobacteria	1224|Proteobacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40
TLS2_k127_1514282_0	1379698.RBG1_1C00001G0607	2.166e-85	304.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
TLS2_k127_1514282_2	344747.PM8797T_12533	1.161e-36	144.0	2DMM9@1|root,32SDB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1514282_1	926560.KE387023_gene1438	5.698e-48	175.0	COG2323@1|root,COG2323@2|Bacteria,1WK27@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
TLS2_k127_1514282_4	319795.Dgeo_1460	5.772e-24	108.0	2C3FA@1|root,32Y72@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1517222_2	204669.Acid345_3343	1.778e-35	143.0	COG1238@1|root,COG1238@2|Bacteria,3Y995@57723|Acidobacteria,2JP5F@204432|Acidobacteriia	204432|Acidobacteriia	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_1517222_1	414684.RC1_3955	2.217e-74	256.0	COG1573@1|root,COG1573@2|Bacteria,1MW8T@1224|Proteobacteria,2TSAR@28211|Alphaproteobacteria,2JSQW@204441|Rhodospirillales	204441|Rhodospirillales	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_1517222_0	794903.OPIT5_11310	1.702e-122	407.0	COG3934@1|root,COG3934@2|Bacteria,46YQT@74201|Verrucomicrobia,3KA0N@414999|Opitutae	414999|Opitutae	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1519958_3	278957.ABEA03000214_gene4241	2.99e-08	62.0	COG2755@1|root,COG2755@2|Bacteria,46XNW@74201|Verrucomicrobia,3K965@414999|Opitutae	414999|Opitutae	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS2_k127_1519958_0	1123242.JH636434_gene5272	8.519e-25	120.0	COG1621@1|root,COG1621@2|Bacteria,2IY26@203682|Planctomycetes	2|Bacteria	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,Dockerin_1,HTH_18,RicinB_lectin_2
TLS2_k127_1519958_1	452637.Oter_2229	1.559e-14	88.0	COG2273@1|root,COG2273@2|Bacteria	2|Bacteria	G	xyloglucan:xyloglucosyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Glyco_hydro_16,Glyco_transf_25,Malectin,Ricin_B_lectin,Trans_reg_C,Trypsin,VCBS
TLS2_k127_1519958_2	1123008.KB905708_gene990	8.533e-12	79.0	COG2273@1|root,COG2273@2|Bacteria,4NTIB@976|Bacteroidetes,2FPHV@200643|Bacteroidia	976|Bacteroidetes	G	Glycosyl hydrolase family 67 N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,Glyco_hydro_67N
TLS2_k127_1520332_0	886293.Sinac_6095	5.506e-228	728.0	COG1073@1|root,COG1073@2|Bacteria,2IYEI@203682|Planctomycetes	203682|Planctomycetes	Q	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS2_k127_1520332_4	204669.Acid345_1477	3.821e-49	187.0	COG0583@1|root,COG0583@2|Bacteria,3Y4EH@57723|Acidobacteria,2JJ60@204432|Acidobacteriia	204432|Acidobacteriia	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_1520332_1	658086.HMPREF0994_07298	3.937e-88	304.0	COG4948@1|root,COG4948@2|Bacteria,1TS0S@1239|Firmicutes,24AE7@186801|Clostridia,27PE0@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.5,4.2.1.6	ko:K01683,ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_1520332_6	1028801.RG1141_PA05340	1.638e-05	55.0	COG3618@1|root,COG3618@2|Bacteria,1P5PT@1224|Proteobacteria,2U3BR@28211|Alphaproteobacteria,4B7I8@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	ko:K07046	ko00051,ko01120,map00051,map01120	-	R10689	RC00537	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
TLS2_k127_1520332_3	1123274.KB899420_gene4011	8.297e-55	204.0	COG0329@1|root,COG0329@2|Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_1520332_5	1307761.L21SP2_2382	6.833e-08	64.0	COG0673@1|root,COG0673@2|Bacteria,2J5CU@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_1520332_2	98439.AJLL01000025_gene203	2.818e-78	276.0	COG2942@1|root,COG2942@2|Bacteria,1G04P@1117|Cyanobacteria	1117|Cyanobacteria	G	PFAM N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)	-	-	5.1.3.8	ko:K01787	ko00520,map00520	-	R01207	RC00290	ko00000,ko00001,ko01000	-	-	-	GlcNAc_2-epim
TLS2_k127_1521380_0	596152.DesU5LDRAFT_0871	2.372e-135	438.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,42MKI@68525|delta/epsilon subdivisions,2WM5H@28221|Deltaproteobacteria,2MEEN@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Domain of unknown function (DUF3459)	treZ-2	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
TLS2_k127_1521380_3	549.BW31_01812	5.131e-21	94.0	COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,1SDHP@1236|Gammaproteobacteria,3W180@53335|Pantoea	1236|Gammaproteobacteria	S	Belongs to the UPF0337 (CsbD) family	yjbJ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	CsbD
TLS2_k127_1521380_2	1183438.GKIL_3693	3e-127	417.0	COG3569@1|root,COG3569@2|Bacteria,1G2R6@1117|Cyanobacteria	1117|Cyanobacteria	L	Eukaryotic DNA topoisomerase I, catalytic core	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
TLS2_k127_1521380_1	402777.KB235903_gene536	5.625e-128	415.0	COG1028@1|root,COG1028@2|Bacteria,1G264@1117|Cyanobacteria,1H9P3@1150|Oscillatoriales	1117|Cyanobacteria	IQ	PFAM short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_1532_3	234267.Acid_7266	1.783e-09	68.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
TLS2_k127_1532_2	1150864.MILUP08_44115	6.159e-20	106.0	COG5563@1|root,COG5563@2|Bacteria,2GRWY@201174|Actinobacteria,4DMB3@85008|Micromonosporales	201174|Actinobacteria	S	FG-GAP repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1532_1	861299.J421_1461	3.362e-40	172.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,HEAT_2,Peptidase_M56,Secretin,TonB_C
TLS2_k127_1532_0	1122621.ATZA01000013_gene3341	3.27e-103	340.0	COG1233@1|root,COG1233@2|Bacteria,4PPPM@976|Bacteroidetes	976|Bacteroidetes	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_1535758_3	643648.Slip_1370	1.731e-26	111.0	COG1067@1|root,COG1067@2|Bacteria,1TQT5@1239|Firmicutes,248NE@186801|Clostridia,42JHB@68298|Syntrophomonadaceae	186801|Clostridia	O	Endopeptidase La	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
TLS2_k127_1535758_0	706587.Desti_3093	2.314e-91	314.0	COG1355@1|root,COG1355@2|Bacteria,1N5H1@1224|Proteobacteria,42TIN@68525|delta/epsilon subdivisions,2WR24@28221|Deltaproteobacteria,2MQK2@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
TLS2_k127_1535758_1	880073.Calab_3265	1.094e-74	252.0	COG0432@1|root,COG0432@2|Bacteria,2NPB7@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TLS2_k127_1535758_2	1519439.JPJG01000066_gene2378	7.304e-38	151.0	COG0009@1|root,COG0237@1|root,COG0009@2|Bacteria,COG0237@2|Bacteria,1TP1I@1239|Firmicutes,248HS@186801|Clostridia,2N716@216572|Oscillospiraceae	186801|Clostridia	HJ	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	sua	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
TLS2_k127_1535758_4	1382306.JNIM01000001_gene3504	5.327e-16	86.0	COG0566@1|root,COG0566@2|Bacteria,2G6MC@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS2_k127_1548725_1	682795.AciX8_4180	2.593e-45	168.0	2C7Y7@1|root,33YEU@2|Bacteria,3Y7RK@57723|Acidobacteria,2JMXF@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	T6SS_VipA
TLS2_k127_1548725_4	682795.AciX8_4181	1.377e-31	130.0	2CCAQ@1|root,2Z8M7@2|Bacteria	2|Bacteria	S	Family of unknown function (DUF5458)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5458
TLS2_k127_1548725_3	278963.ATWD01000001_gene4677	3.327e-37	149.0	2BT90@1|root,32NED@2|Bacteria,3Y6W8@57723|Acidobacteria,2JKW6@204432|Acidobacteriia	204432|Acidobacteriia	S	Family of unknown function (DUF5458)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5458
TLS2_k127_1548725_0	682795.AciX8_4181	3.632e-71	245.0	2CCAQ@1|root,2Z8M7@2|Bacteria	2|Bacteria	S	Family of unknown function (DUF5458)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5458
TLS2_k127_1548725_2	278963.ATWD01000001_gene4678	7.733e-38	147.0	2F4U9@1|root,33XGN@2|Bacteria,3Y7YR@57723|Acidobacteria,2JN2P@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_155432_0	1121904.ARBP01000026_gene679	1.17e-303	949.0	COG3408@1|root,COG3408@2|Bacteria,4NHHR@976|Bacteroidetes,47MK4@768503|Cytophagia	976|Bacteroidetes	G	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
TLS2_k127_155432_1	1049564.TevJSym_al00100	1.573e-52	201.0	COG2202@1|root,COG2203@1|root,COG4585@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,1T1IF@1236|Gammaproteobacteria,1J794@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA_3,LapD_MoxY_N,PAS,PAS_9
TLS2_k127_1557494_1	443143.GM18_4199	2.68e-40	159.0	COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,42NBF@68525|delta/epsilon subdivisions,2WNW9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	PFAM GTP-binding signal recognition particle SRP54 G- domain	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
TLS2_k127_1557494_0	398767.Glov_3286	2.062e-166	526.0	COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,42NB2@68525|delta/epsilon subdivisions,2WIWG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
TLS2_k127_1575172_1	234267.Acid_3489	1.175e-113	386.0	COG0745@1|root,COG0745@2|Bacteria,3Y2I8@57723|Acidobacteria	57723|Acidobacteria	KT	Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	Malectin
TLS2_k127_1575172_2	1499967.BAYZ01000148_gene1748	4.588e-40	168.0	COG1538@1|root,COG1538@2|Bacteria,2NP5D@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
TLS2_k127_1575172_0	690850.Desaf_3621	3.834e-321	1014.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2M7S1@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
TLS2_k127_1576309_0	1358423.N180_17725	4.279e-100	332.0	COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,1INPQ@117747|Sphingobacteriia	976|Bacteroidetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_1576309_3	1198452.Jab_1c20610	5.861e-75	269.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_1576309_1	1121957.ATVL01000007_gene1594	3.862e-98	336.0	COG0577@1|root,COG0577@2|Bacteria,4NI8K@976|Bacteroidetes,47KIT@768503|Cytophagia	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_1576309_2	761193.Runsl_1140	3.877e-90	304.0	COG1136@1|root,COG1136@2|Bacteria,4NFDW@976|Bacteroidetes,47N2Z@768503|Cytophagia	976|Bacteroidetes	V	ATPases associated with a variety of cellular activities	ytrE_3	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1576309_4	1185876.BN8_03101	1e-68	248.0	COG0845@1|root,COG0845@2|Bacteria,4NIJI@976|Bacteroidetes,47KW8@768503|Cytophagia	976|Bacteroidetes	M	TIGRFAM efflux transporter, RND family, MFP subunit	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,OEP
TLS2_k127_1576309_5	305900.GV64_15775	3.661e-18	92.0	COG3184@1|root,COG3184@2|Bacteria,1MZWE@1224|Proteobacteria,1SAZ9@1236|Gammaproteobacteria,1XQAP@135619|Oceanospirillales	135619|Oceanospirillales	S	Uncharacterized protein conserved in bacteria (DUF2059)	-	-	-	ko:K09924	-	-	-	-	ko00000	-	-	-	DUF2059
TLS2_k127_1585923_0	1267533.KB906738_gene2186	1.256e-143	466.0	COG1529@1|root,COG1529@2|Bacteria,3Y3J7@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C2
TLS2_k127_1588079_4	1382359.JIAL01000001_gene924	4.54e-21	100.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	epsE	-	-	ko:K16712	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.66.2.11	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
TLS2_k127_1588079_3	631362.Thi970DRAFT_02059	1.233e-23	107.0	COG2197@1|root,COG4585@1|root,COG2197@2|Bacteria,COG4585@2|Bacteria,1QTU2@1224|Proteobacteria	1224|Proteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,PAS_9,Response_reg
TLS2_k127_1588079_2	1121468.AUBR01000002_gene716	4.153e-86	295.0	COG1397@1|root,COG1397@2|Bacteria,1TQXG@1239|Firmicutes,24C2X@186801|Clostridia,42GV9@68295|Thermoanaerobacterales	186801|Clostridia	O	PFAM ADP-ribosylation Crystallin J1	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
TLS2_k127_1588079_0	986075.CathTA2_2241	4.65e-225	721.0	COG1620@1|root,COG1620@2|Bacteria,1TQNM@1239|Firmicutes,4HAF3@91061|Bacilli	91061|Bacilli	C	L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
TLS2_k127_1588079_1	518766.Rmar_1740	1.542e-87	306.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,1FK20@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_1601739_2	1121451.DESAM_22427	6.943e-83	278.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42MV2@68525|delta/epsilon subdivisions,2WJ7U@28221|Deltaproteobacteria,2M839@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_1601739_0	1340493.JNIF01000003_gene2993	4.868e-226	713.0	COG0442@1|root,COG0442@2|Bacteria,3Y329@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
TLS2_k127_1601739_3	204669.Acid345_1263	2.747e-46	171.0	COG0698@1|root,COG0698@2|Bacteria,3Y50S@57723|Acidobacteria,2JJEK@204432|Acidobacteriia	2|Bacteria	G	Ribose/Galactose Isomerase	rpiB	GO:0003674,GO:0003824,GO:0004751,GO:0005975,GO:0008150,GO:0008152,GO:0009056,GO:0009743,GO:0009758,GO:0009987,GO:0010033,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0042221,GO:0044238,GO:0050896,GO:0051716,GO:0070887,GO:0071310,GO:0071322,GO:0071704,GO:1901575,GO:1901700,GO:1901701	5.3.1.26,5.3.1.34,5.3.1.6	ko:K01808,ko:K01819,ko:K21911	ko00030,ko00051,ko00052,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00052,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R03240,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO3353	DUF3666,LacAB_rpiB
TLS2_k127_1601739_1	639282.DEFDS_0485	6.586e-177	564.0	COG0112@1|root,COG0112@2|Bacteria,2GERI@200930|Deferribacteres	200930|Deferribacteres	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TLS2_k127_1601739_4	240015.ACP_1651	9.727e-33	132.0	COG1199@1|root,COG1199@2|Bacteria,3Y3DN@57723|Acidobacteria,2JHJZ@204432|Acidobacteriia	204432|Acidobacteriia	L	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
TLS2_k127_160847_0	1121904.ARBP01000008_gene3234	1.863e-161	530.0	COG5492@1|root,COG5492@2|Bacteria,4NEAB@976|Bacteroidetes,47TBW@768503|Cytophagia	976|Bacteroidetes	N	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF5060
TLS2_k127_160847_3	243090.RB3767	1.52e-117	388.0	COG0473@1|root,COG0473@2|Bacteria,2IXJZ@203682|Planctomycetes	203682|Planctomycetes	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_160847_6	639030.JHVA01000001_gene1901	1.633e-48	184.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_160847_4	1122179.KB890480_gene3122	3.775e-114	383.0	COG2271@1|root,COG2271@2|Bacteria,4NGCR@976|Bacteroidetes,1IXUR@117747|Sphingobacteriia	976|Bacteroidetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_160847_2	1178825.ALIH01000004_gene2795	6.542e-133	437.0	COG0673@1|root,COG0673@2|Bacteria,4NJEP@976|Bacteroidetes,1I3KI@117743|Flavobacteriia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_160847_5	1232449.BAHV02000008_gene670	5.528e-98	331.0	COG0176@1|root,COG0176@2|Bacteria,1U9RA@1239|Firmicutes,24DCI@186801|Clostridia	186801|Clostridia	H	PFAM Transaldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TLS2_k127_160847_1	525904.Tter_0632	2.034e-154	503.0	COG0699@1|root,COG0699@2|Bacteria,2NQN2@2323|unclassified Bacteria	2|Bacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
TLS2_k127_161036_3	452637.Oter_4517	1.566e-90	312.0	COG0673@1|root,COG0673@2|Bacteria,46UJR@74201|Verrucomicrobia,3K94Y@414999|Opitutae	2|Bacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_161036_6	344747.PM8797T_11996	8.766e-48	181.0	COG0673@1|root,COG2133@1|root,COG0673@2|Bacteria,COG2133@2|Bacteria,2IWZY@203682|Planctomycetes	203682|Planctomycetes	G	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_161036_2	452637.Oter_4517	3.17e-98	339.0	COG0673@1|root,COG0673@2|Bacteria,46UJR@74201|Verrucomicrobia,3K94Y@414999|Opitutae	2|Bacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_161036_4	1123248.KB893328_gene937	2.244e-84	288.0	COG1082@1|root,COG1082@2|Bacteria,4NG1K@976|Bacteroidetes,1IQA4@117747|Sphingobacteriia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_161036_1	1195236.CTER_5009	2.735e-115	384.0	COG2768@1|root,COG2768@2|Bacteria,1TPRV@1239|Firmicutes,247PJ@186801|Clostridia,3WNJU@541000|Ruminococcaceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088,DUF362
TLS2_k127_161036_0	484770.UFO1_4161	3.456e-135	456.0	COG1086@1|root,COG1086@2|Bacteria,1TR3W@1239|Firmicutes,4H1ZX@909932|Negativicutes	909932|Negativicutes	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
TLS2_k127_161036_5	338966.Ppro_3150	1.276e-62	239.0	COG0784@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,43SAI@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
TLS2_k127_1616532_0	234267.Acid_4352	7.997e-102	347.0	COG1215@1|root,COG2227@1|root,COG1215@2|Bacteria,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	ko:K07011,ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2,Methyltransf_23
TLS2_k127_1616532_1	1047013.AQSP01000084_gene761	3.612e-75	262.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
TLS2_k127_1624565_4	644282.Deba_2501	1.114e-59	220.0	COG0845@1|root,COG0845@2|Bacteria,1QZQZ@1224|Proteobacteria,42STU@68525|delta/epsilon subdivisions,2WPYM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
TLS2_k127_1624565_0	485916.Dtox_0939	7.453e-258	814.0	COG2274@1|root,COG2274@2|Bacteria,1V77J@1239|Firmicutes,25E7C@186801|Clostridia,261EJ@186807|Peptococcaceae	186801|Clostridia	V	NHLM bacteriocin system ABC transporter, peptidase ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran,Peptidase_C39
TLS2_k127_1624565_1	767817.Desgi_2846	1.074e-220	717.0	COG2274@1|root,COG2274@2|Bacteria,1TRMR@1239|Firmicutes,248Z2@186801|Clostridia,261E8@186807|Peptococcaceae	186801|Clostridia	P	NHLM bacteriocin system ABC transporter, ATP-binding protein	-	-	-	ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
TLS2_k127_1624565_2	1392502.JNIO01000008_gene1471	1.602e-112	378.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes	1239|Firmicutes	C	Radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
TLS2_k127_1624565_3	378806.STAUR_4152	1.488e-101	356.0	COG1032@1|root,COG1032@2|Bacteria,1NAY8@1224|Proteobacteria,42TR8@68525|delta/epsilon subdivisions,2WQC1@28221|Deltaproteobacteria,2YUBN@29|Myxococcales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
TLS2_k127_1624565_7	1444711.CCJF01000005_gene793	4.647e-05	53.0	COG0454@1|root,COG0456@2|Bacteria,2JGYG@204428|Chlamydiae	204428|Chlamydiae	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1631944_2	1265845.PWEIH_07386	1.92e-30	133.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,4HBRJ@91061|Bacilli,26J3W@186820|Listeriaceae	91061|Bacilli	F	xylulose kinase	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU17610	FGGY_C,FGGY_N
TLS2_k127_1631944_0	1122605.KB893637_gene3223	7.503e-126	409.0	COG0363@1|root,COG0363@2|Bacteria	2|Bacteria	G	glucosamine-6-phosphate deaminase activity	nagB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	3.1.1.31,3.5.99.6	ko:K01057,ko:K02564	ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R00765,R02035	RC00163,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
TLS2_k127_1631944_1	234267.Acid_3126	1.039e-85	306.0	COG1629@1|root,COG4771@2|Bacteria,3Y3KA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_1646867_2	365044.Pnap_2178	1.453e-29	128.0	2A2RR@1|root,30R50@2|Bacteria,1RF6F@1224|Proteobacteria,2VYJ0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Alginate export	-	-	-	ko:K16081	-	-	-	-	ko00000,ko02000	1.B.13.1	-	-	Alginate_exp
TLS2_k127_1646867_0	234267.Acid_7254	1.22e-254	797.0	COG1217@1|root,COG1217@2|Bacteria,3Y33Q@57723|Acidobacteria	57723|Acidobacteria	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_1646867_1	234267.Acid_2359	8.375e-129	424.0	COG0535@1|root,COG0535@2|Bacteria,3Y3QA@57723|Acidobacteria	2|Bacteria	S	Radical SAM domain protein	-	-	-	ko:K15045	ko05164,map05164	-	-	-	ko00000,ko00001	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
TLS2_k127_1651123_2	1121930.AQXG01000001_gene1262	6.084e-81	277.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TLS2_k127_1651123_0	1121930.AQXG01000001_gene1261	0.0	1396.0	COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
TLS2_k127_1651123_1	713587.THITH_08540	1.183e-144	466.0	COG0702@1|root,COG0702@2|Bacteria,1N12V@1224|Proteobacteria,1S93R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
TLS2_k127_1655072_0	671143.DAMO_0301	7.258e-59	221.0	COG0457@1|root,COG4745@1|root,COG0457@2|Bacteria,COG4745@2|Bacteria,2NQJ6@2323|unclassified Bacteria	2|Bacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL,PMT_2,TPR_2,TPR_8
TLS2_k127_1655072_1	444158.MmarC6_0582	6.042e-43	167.0	COG0438@1|root,arCOG01415@2157|Archaea,2XUVW@28890|Euryarchaeota,23R82@183939|Methanococci	183939|Methanococci	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_1667165_3	204669.Acid345_4231	3.329e-85	295.0	COG5009@1|root,COG5009@2|Bacteria,3Y31C@57723|Acidobacteria,2JHJY@204432|Acidobacteriia	204432|Acidobacteriia	M	Penicillin-binding protein 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS2_k127_1667165_4	1267535.KB906767_gene3788	1.255e-44	166.0	COG0782@1|root,COG0782@2|Bacteria,3Y49X@57723|Acidobacteria,2JJ1A@204432|Acidobacteriia	204432|Acidobacteriia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TLS2_k127_1667165_2	671143.DAMO_2690	3.517e-118	397.0	COG1007@1|root,COG1007@2|Bacteria,2NNMY@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_1667165_1	671143.DAMO_2691	5.233e-167	539.0	COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria	2|Bacteria	C	NADH-quinone oxidoreductase, chain M	nuoM-1	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
TLS2_k127_1667165_0	247490.KSU1_D0317	1.58e-201	646.0	COG1009@1|root,COG1009@2|Bacteria,2IX10@203682|Planctomycetes	203682|Planctomycetes	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
TLS2_k127_1679064_0	1267533.KB906734_gene4002	3.456e-99	351.0	COG0577@1|root,COG0577@2|Bacteria	1267533.KB906734_gene4002|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1679064_2	1267535.KB906767_gene2343	1.704e-46	169.0	COG1695@1|root,COG1695@2|Bacteria,3Y4XK@57723|Acidobacteria,2JJR3@204432|Acidobacteriia	2|Bacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_1679064_1	497964.CfE428DRAFT_3855	4.183e-79	273.0	COG0620@1|root,COG0620@2|Bacteria,46W8R@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Cobalamin-independent synthase, Catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
TLS2_k127_1681030_0	324602.Caur_1745	9.219e-116	382.0	COG0451@1|root,COG0451@2|Bacteria,2G6ET@200795|Chloroflexi,375HU@32061|Chloroflexia	32061|Chloroflexia	M	short-chain dehydrogenase reductase SDR	-	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_1681030_2	472759.Nhal_3312	7.134e-84	286.0	COG2227@1|root,COG2227@2|Bacteria,1N7WN@1224|Proteobacteria	1224|Proteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS2_k127_1681030_1	1288826.MSNKSG1_06943	1.978e-94	317.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria,469ZI@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	carbamoyl transferase, NodU family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TLS2_k127_1687409_0	886293.Sinac_6746	1.444e-166	537.0	COG3356@1|root,COG3356@2|Bacteria,2IXB9@203682|Planctomycetes	203682|Planctomycetes	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
TLS2_k127_1687409_1	344747.PM8797T_01669	9.223e-155	494.0	COG0363@1|root,COG0363@2|Bacteria,2IXX0@203682|Planctomycetes	203682|Planctomycetes	G	Glucosamine-6-phosphate isomerase	-	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	-
TLS2_k127_1687409_2	234267.Acid_4908	4.561e-09	58.0	COG0673@1|root,COG0673@2|Bacteria,3Y6XR@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_1689845_1	926549.KI421517_gene1530	1.151e-134	444.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,47JNX@768503|Cytophagia	976|Bacteroidetes	S	PFAM Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_1689845_0	287986.DV20_23835	3.173e-149	485.0	COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria,4E15T@85010|Pseudonocardiales	201174|Actinobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	algD	-	1.1.1.132	ko:K00066	ko00051,ko00520,ko02020,map00051,map00520,map02020	-	R00880	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS2_k127_1689845_2	1380390.JIAT01000009_gene1931	1.112e-36	152.0	COG0438@1|root,COG0438@2|Bacteria,2GVEW@201174|Actinobacteria,4CSE3@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4
TLS2_k127_1703472_1	1267534.KB906758_gene2412	1.189e-78	287.0	COG4775@1|root,COG4775@2|Bacteria,3Y2Q9@57723|Acidobacteria,2JHYD@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM outer membrane protein assembly complex, YaeT protein	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TLS2_k127_1703472_2	1385511.N783_00405	4.012e-55	203.0	COG3861@1|root,COG3861@2|Bacteria,1V5R4@1239|Firmicutes,4HHWG@91061|Bacilli,2YBI4@289201|Pontibacillus	91061|Bacilli	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
TLS2_k127_1703472_0	518766.Rmar_0629	1.728e-234	760.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,4NERT@976|Bacteroidetes,1FJ3R@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	MU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	BSP,Bac_surface_Ag,PD40
TLS2_k127_1703472_3	330214.NIDE1491	2.73e-40	164.0	COG0745@1|root,COG2202@1|root,COG3829@1|root,COG4585@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4585@2|Bacteria,COG5002@2|Bacteria,3J12P@40117|Nitrospirae	40117|Nitrospirae	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA_3,PAS_9
TLS2_k127_1710257_1	234267.Acid_1537	5.083e-88	297.0	COG0124@1|root,COG0124@2|Bacteria,3Y3IY@57723|Acidobacteria	57723|Acidobacteria	J	PFAM tRNA synthetase, class II (G, H, P and S)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TLS2_k127_1710257_0	204669.Acid345_1065	2.311e-154	516.0	COG0744@1|root,COG0744@2|Bacteria,3Y42I@57723|Acidobacteria,2JI7Q@204432|Acidobacteriia	204432|Acidobacteriia	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS2_k127_1726790_0	880073.Calab_1770	1.926e-127	419.0	COG1108@1|root,COG1108@2|Bacteria,2NPBK@2323|unclassified Bacteria	2|Bacteria	P	ABC 3 transport family	mntD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944	-	ko:K11709	ko02010,map02010	M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC-3
TLS2_k127_1726790_3	880073.Calab_1771	4.491e-111	371.0	COG1108@1|root,COG1108@2|Bacteria,2NPC2@2323|unclassified Bacteria	2|Bacteria	U	ABC 3 transport family	mntC	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944	-	ko:K11708	ko02010,map02010	M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC-3,Fe_dep_repr_C
TLS2_k127_1726790_4	880073.Calab_1772	2.589e-108	358.0	COG1121@1|root,COG1121@2|Bacteria,2NPKC@2323|unclassified Bacteria	2|Bacteria	P	ATPases associated with a variety of cellular activities	mntB	-	-	ko:K09817,ko:K11710	ko02010,map02010	M00242,M00319	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	iYO844.BSU30760	ABC_tran
TLS2_k127_1726790_2	479434.Sthe_3156	8.579e-118	386.0	COG0803@1|root,COG0803@2|Bacteria,2G8F6@200795|Chloroflexi,27XHP@189775|Thermomicrobia	200795|Chloroflexi	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K09818,ko:K11707	ko02010,map02010	M00243,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ZnuA
TLS2_k127_1726790_6	479434.Sthe_1384	1.247e-63	227.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,2G6N4@200795|Chloroflexi,27YBV@189775|Thermomicrobia	189775|Thermomicrobia	K	FeoA	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
TLS2_k127_1726790_7	1267535.KB906767_gene3948	5.106e-40	166.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_1726790_1	644282.Deba_2958	1.015e-122	403.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2WJE8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
TLS2_k127_1726790_5	1366050.N234_03715	1.476e-65	231.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2VHK9@28216|Betaproteobacteria,1K30Z@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_1740851_0	330214.NIDE1167	7.139e-203	653.0	COG1201@1|root,COG1201@2|Bacteria	2|Bacteria	L	RNA secondary structure unwinding	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
TLS2_k127_174255_2	443143.GM18_4033	1.4e-175	559.0	COG1729@1|root,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,42TQ9@68525|delta/epsilon subdivisions,2WR3B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
TLS2_k127_174255_0	443143.GM18_4034	3.823e-299	927.0	COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,42Z0Q@68525|delta/epsilon subdivisions,2WU0G@28221|Deltaproteobacteria,43T6R@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_174255_3	443143.GM18_4035	1.378e-70	250.0	2B4XH@1|root,31XQC@2|Bacteria,1RHJF@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_174255_1	443143.GM18_4036	1.168e-242	753.0	COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS2_k127_174480_4	1111479.AXAR01000003_gene1515	1.508e-32	132.0	COG1853@1|root,COG1853@2|Bacteria,1V5M1@1239|Firmicutes,4HJWQ@91061|Bacilli	91061|Bacilli	S	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family	-	-	-	ko:K16048	ko00984,ko01100,map00984,map01100	-	R09819	RC00236	ko00000,ko00001,ko01000	-	-	-	Flavin_Reduct
TLS2_k127_174480_1	1094715.CM001373_gene2215	1.466e-152	495.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1JCP3@118969|Legionellales	118969|Legionellales	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
TLS2_k127_174480_0	572477.Alvin_2625	7.618e-206	648.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,1RQ3D@1236|Gammaproteobacteria,1WWR9@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
TLS2_k127_174480_3	631362.Thi970DRAFT_00749	1.917e-46	171.0	COG4747@1|root,COG4747@2|Bacteria,1RDCG@1224|Proteobacteria,1S26H@1236|Gammaproteobacteria,1WY18@135613|Chromatiales	135613|Chromatiales	S	PFAM Amino acid-binding ACT	-	-	-	-	-	-	-	-	-	-	-	-	ACT
TLS2_k127_174480_2	234267.Acid_0058	2.085e-58	207.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	yhdR	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_1746268_0	234267.Acid_6996	0.0	1504.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,3Y415@57723|Acidobacteria	57723|Acidobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
TLS2_k127_1757948_4	234267.Acid_1401	9.167e-44	165.0	COG2823@1|root,COG2823@2|Bacteria,3Y4KR@57723|Acidobacteria	57723|Acidobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS2_k127_1757948_0	1267535.KB906767_gene3179	7.222e-110	365.0	COG2220@1|root,COG2220@2|Bacteria,3Y2TV@57723|Acidobacteria,2JHT8@204432|Acidobacteriia	204432|Acidobacteriia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_1757948_6	309807.SRU_2822	2.005e-05	54.0	COG2968@1|root,COG2968@2|Bacteria,4P8H6@976|Bacteroidetes,1FJN4@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
TLS2_k127_1757948_5	521045.Kole_1995	8.316e-42	169.0	COG1649@1|root,COG1649@2|Bacteria,2GCSB@200918|Thermotogae	200918|Thermotogae	S	Glycosyl hydrolase-like 10	-	-	-	-	-	-	-	-	-	-	-	-	GHL10
TLS2_k127_1757948_2	1173023.KE650771_gene4801	1.027e-66	239.0	2DBB1@1|root,2Z854@2|Bacteria,1G05N@1117|Cyanobacteria,1JI5N@1189|Stigonemataceae	1117|Cyanobacteria	S	Domain of Unknown Function (DUF1206)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1206
TLS2_k127_1757948_1	1267535.KB906767_gene2183	4.898e-79	278.0	COG2006@1|root,COG2006@2|Bacteria,3Y6M1@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
TLS2_k127_1757948_3	247490.KSU1_B0677	2.095e-45	189.0	COG1520@1|root,COG1520@2|Bacteria,2IYZY@203682|Planctomycetes	203682|Planctomycetes	S	protein kinase related protein	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TLS2_k127_1762325_3	1202532.FF52_01790	1.405e-05	48.0	2DMN1@1|root,32SKS@2|Bacteria,4NRHF@976|Bacteroidetes,1I2P4@117743|Flavobacteriia,2NSYT@237|Flavobacterium	976|Bacteroidetes	G	Carbohydrate-binding family 9	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
TLS2_k127_1762325_1	1340493.JNIF01000004_gene420	3.742e-112	374.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,Peptidase_M9,zf-ribbon_3
TLS2_k127_1762325_0	344747.PM8797T_27250	4.463e-285	891.0	COG3356@1|root,COG4625@1|root,COG3356@2|Bacteria,COG4625@2|Bacteria,2IXDY@203682|Planctomycetes	203682|Planctomycetes	G	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk,Laminin_G_3
TLS2_k127_1762325_2	234267.Acid_4090	9.477e-88	297.0	COG1187@1|root,COG1187@2|Bacteria,3Y6Y9@57723|Acidobacteria	57723|Acidobacteria	J	RNA pseudouridylate synthase	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_1779786_0	1499967.BAYZ01000059_gene4782	5.94e-82	291.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HAMP,HATPase_c,HisKA,PAS,dCache_3
TLS2_k127_1779786_1	429009.Adeg_2010	2.761e-66	233.0	COG0378@1|root,COG0378@2|Bacteria,1TS00@1239|Firmicutes,248T1@186801|Clostridia,42GEU@68295|Thermoanaerobacterales	186801|Clostridia	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
TLS2_k127_1779786_3	563192.HMPREF0179_01508	4.7e-05	50.0	COG0375@1|root,COG0375@2|Bacteria,1PTY5@1224|Proteobacteria,42U07@68525|delta/epsilon subdivisions,2WPIB@28221|Deltaproteobacteria,2MCEE@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
TLS2_k127_1779786_2	338966.Ppro_2783	6.323e-17	81.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42NH3@68525|delta/epsilon subdivisions,2WNT3@28221|Deltaproteobacteria	1224|Proteobacteria	C	Belongs to the complex I 20 kDa subunit family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
TLS2_k127_1796364_1	706587.Desti_3923	2.067e-83	282.0	COG1319@1|root,COG1319@2|Bacteria,1MVJS@1224|Proteobacteria,42RX4@68525|delta/epsilon subdivisions,2WNBJ@28221|Deltaproteobacteria,2MQZF@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_1796364_0	335543.Sfum_2510	0.0	1031.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2MR87@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
TLS2_k127_1805611_0	1177154.Y5S_01973	9.453e-73	250.0	28JTN@1|root,2Z9IV@2|Bacteria,1RCK3@1224|Proteobacteria,1S21G@1236|Gammaproteobacteria,1XPME@135619|Oceanospirillales	135619|Oceanospirillales	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1805611_1	395494.Galf_0376	9.22e-65	234.0	COG1846@1|root,COG1846@2|Bacteria,1RETW@1224|Proteobacteria,2W0K4@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1805611_3	658088.HMPREF0987_01063	2.468e-28	128.0	COG1957@1|root,COG1957@2|Bacteria,1U70Y@1239|Firmicutes,249Q0@186801|Clostridia,27MYN@186928|unclassified Lachnospiraceae	186801|Clostridia	F	Inosine-uridine preferring nucleoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1593,IU_nuc_hydro
TLS2_k127_1805611_2	313628.LNTAR_16613	1.033e-44	168.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
TLS2_k127_1806357_2	1321778.HMPREF1982_00432	8.182e-53	191.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,2683F@186813|unclassified Clostridiales	186801|Clostridia	E	Glutamine synthetase, catalytic domain	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
TLS2_k127_1806357_3	640132.Srot_2063	7.992e-07	60.0	290UJ@1|root,2ZNGJ@2|Bacteria,2I47K@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1806357_0	243233.MCA1022	1.182e-162	516.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1XDN6@135618|Methylococcales	135618|Methylococcales	H	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_1806357_1	886293.Sinac_0957	5.59e-127	417.0	COG0526@1|root,COG1225@1|root,COG0526@2|Bacteria,COG1225@2|Bacteria,2J1ZV@203682|Planctomycetes	203682|Planctomycetes	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_1810844_2	234267.Acid_6981	1.232e-59	214.0	COG0289@1|root,COG0289@2|Bacteria,3Y50R@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the DapB family	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
TLS2_k127_1810844_0	1267535.KB906767_gene2119	1.788e-138	455.0	COG0527@1|root,COG0527@2|Bacteria,3Y34W@57723|Acidobacteria,2JHV2@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT
TLS2_k127_1810844_3	443144.GM21_2626	8.473e-37	143.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42MN8@68525|delta/epsilon subdivisions,2WQKR@28221|Deltaproteobacteria,43UY7@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_1810844_1	247490.KSU1_C0443	2.865e-117	394.0	COG0526@1|root,COG3391@1|root,COG0526@2|Bacteria,COG3391@2|Bacteria,2IXWV@203682|Planctomycetes	203682|Planctomycetes	CO	PFAM NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL,Thioredoxin_8
TLS2_k127_1827423_0	234267.Acid_7690	1.422e-50	195.0	COG3712@1|root,COG3712@2|Bacteria,3Y772@57723|Acidobacteria	57723|Acidobacteria	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
TLS2_k127_1827423_1	73044.JNXP01000008_gene3316	4.936e-16	87.0	COG1595@1|root,COG1595@2|Bacteria,2GN65@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_1827423_2	1121035.AUCH01000002_gene1539	3.248e-06	56.0	COG2982@1|root,COG2982@2|Bacteria,1NBZ0@1224|Proteobacteria,2VPGQ@28216|Betaproteobacteria,2KVEP@206389|Rhodocyclales	206389|Rhodocyclales	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
TLS2_k127_1834324_2	1329516.JPST01000003_gene1026	2.415e-114	377.0	COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,4H9MX@91061|Bacilli,27BA9@186824|Thermoactinomycetaceae	91061|Bacilli	E	Aminomethyltransferase folate-binding domain	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TLS2_k127_1834324_4	66373.JOFQ01000007_gene3299	2.937e-43	162.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
TLS2_k127_1834324_1	671143.DAMO_0706	3.149e-151	490.0	COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
TLS2_k127_1834324_0	1267533.KB906733_gene2852	9.921e-188	604.0	COG1003@1|root,COG1003@2|Bacteria,3Y2UZ@57723|Acidobacteria,2JIAN@204432|Acidobacteriia	204432|Acidobacteriia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
TLS2_k127_1834324_3	439235.Dalk_0656	1.686e-85	307.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,2MHZP@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Signal transducing histidine kinase, homodimeric	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
TLS2_k127_1855096_2	68570.DC74_8032	9.058e-20	105.0	COG1262@1|root,COG1262@2|Bacteria,2GK9Q@201174|Actinobacteria	201174|Actinobacteria	KLT	Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine	-	-	-	ko:K20333	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	FGE-sulfatase
TLS2_k127_1855096_0	590998.Celf_0345	1.785e-57	227.0	COG3507@1|root,COG5297@1|root,COG3507@2|Bacteria,COG5297@2|Bacteria,2I363@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 28 family	yesW	-	-	-	-	-	-	-	-	-	-	-	CBM_2
TLS2_k127_1855096_3	749414.SBI_09188	9.579e-08	63.0	COG5297@1|root,COG5297@2|Bacteria,2GMQN@201174|Actinobacteria	201174|Actinobacteria	G	PFAM glycoside hydrolase, family 9	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_4_9,CelD_N,Glyco_hydro_9,I-set
TLS2_k127_1857533_0	1033743.CAES01000009_gene1899	1.339e-75	261.0	COG1028@1|root,COG1028@2|Bacteria	1033743.CAES01000009_gene1899|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1865371_2	234267.Acid_7874	3.593e-94	315.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_1865371_0	204669.Acid345_1734	6.906e-205	650.0	COG2204@1|root,COG2204@2|Bacteria,3Y2J1@57723|Acidobacteria,2JIIE@204432|Acidobacteriia	57723|Acidobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_1865371_1	926550.CLDAP_28980	3.588e-154	495.0	COG1085@1|root,COG1085@2|Bacteria,2G6K5@200795|Chloroflexi	200795|Chloroflexi	H	TIGRFAM galactose-1-phosphate uridylyltransferase	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
TLS2_k127_1883972_1	234267.Acid_6537	3.05e-98	335.0	COG1073@1|root,COG1073@2|Bacteria,3Y6M5@57723|Acidobacteria	57723|Acidobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1883972_0	497964.CfE428DRAFT_5010	6.239e-99	330.0	COG1940@1|root,COG1940@2|Bacteria,46SBQ@74201|Verrucomicrobia	74201|Verrucomicrobia	GK	carbohydrate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1891944_1	1267535.KB906767_gene904	3.101e-68	238.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
TLS2_k127_1891944_0	1340493.JNIF01000003_gene4788	7.993e-98	339.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,3Y6YC@57723|Acidobacteria	57723|Acidobacteria	S	Putative glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
TLS2_k127_1898886_1	909663.KI867150_gene2392	3.583e-71	250.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42QC6@68525|delta/epsilon subdivisions,2WIRV@28221|Deltaproteobacteria,2MR30@213462|Syntrophobacterales	28221|Deltaproteobacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	arnA	-	1.1.1.305,2.1.2.13	ko:K10011,ko:K12449	ko00520,ko01100,ko01503,map00520,map01100,map01503	M00721,M00761	R01384,R01386,R07658,R07660	RC00026,RC00508,RC01575,RC01811,RC01812	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase,Formyl_trans_C,Formyl_trans_N
TLS2_k127_1898886_0	1254432.SCE1572_06760	2.22e-85	293.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
TLS2_k127_1898886_2	1123269.NX02_24205	1.099e-16	92.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS2_k127_1900789_1	1122931.AUAE01000013_gene2068	2.482e-60	216.0	COG3852@1|root,COG3852@2|Bacteria,4PPPV@976|Bacteroidetes,2G17D@200643|Bacteroidia,22ZVH@171551|Porphyromonadaceae	976|Bacteroidetes	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_1900789_0	429009.Adeg_0173	1.239e-123	411.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,42J66@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02481,ko:K07714,ko:K10943	ko02020,ko05111,map02020,map05111	M00500,M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_1900789_4	580340.Tlie_0441	4.914e-08	65.0	COG1277@1|root,COG1277@2|Bacteria,3TC47@508458|Synergistetes	508458|Synergistetes	S	ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS2_k127_1900789_2	1047013.AQSP01000134_gene1374	1.233e-46	187.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992,ko:K16919	ko02010,map02010	M00254,M00584	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4,ABC_transp_aux
TLS2_k127_1900789_3	1235803.C825_05279	2.867e-44	164.0	COG1131@1|root,COG1131@2|Bacteria,4NE3Z@976|Bacteroidetes,2FR55@200643|Bacteroidia,22ZR5@171551|Porphyromonadaceae	976|Bacteroidetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1908468_0	1382359.JIAL01000001_gene611	1.32e-112	372.0	COG0673@1|root,COG0673@2|Bacteria,3Y4KS@57723|Acidobacteria,2JM5G@204432|Acidobacteriia	204432|Acidobacteriia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_1908468_1	330214.NIDE1431	2.504e-103	343.0	COG2321@1|root,COG2321@2|Bacteria	2|Bacteria	S	Putative neutral zinc metallopeptidase	ypfJ	GO:0005575,GO:0005576	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
TLS2_k127_1908468_2	180332.JTGN01000022_gene1511	5.554e-72	256.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,24G9W@186801|Clostridia	186801|Clostridia	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_1910173_0	1340493.JNIF01000004_gene597	1.554e-84	297.0	COG1629@1|root,COG1629@2|Bacteria,3Y6Z5@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_1915191_0	1195246.AGRI_02890	1.339e-49	192.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RN5Z@1236|Gammaproteobacteria,46525@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	permease	VP2476	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_1915191_1	1220534.B655_2035	7.296e-32	139.0	COG0500@1|root,arCOG01773@2157|Archaea,2Y131@28890|Euryarchaeota	28890|Euryarchaeota	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS2_k127_1915191_2	671143.DAMO_3159	4.237e-18	90.0	COG1595@1|root,COG1595@2|Bacteria,2NR5T@2323|unclassified Bacteria	2|Bacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_1918461_6	436114.SYO3AOP1_1554	4.807e-06	51.0	COG0490@1|root,COG0490@2|Bacteria,2G45Z@200783|Aquificae	200783|Aquificae	P	TrkA-C domain protein	-	-	-	ko:K07228	-	-	-	-	ko00000	-	-	-	TrkA_C
TLS2_k127_1918461_0	1123256.KB907934_gene2402	1.928e-192	610.0	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,1RRMM@1236|Gammaproteobacteria,1X2YX@135614|Xanthomonadales	135614|Xanthomonadales	E	phospho-2-dehydro-3-deoxyheptonate aldolase	dhs1	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
TLS2_k127_1918461_5	398512.JQKC01000032_gene4480	3.944e-11	76.0	COG5305@1|root,COG5305@2|Bacteria,1UXXF@1239|Firmicutes,249M9@186801|Clostridia,3WGH7@541000|Ruminococcaceae	186801|Clostridia	P	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1,DUF2141,PMT_2
TLS2_k127_1918461_4	930169.B5T_01562	1.729e-16	91.0	28IX1@1|root,2Z8V3@2|Bacteria,1N0WD@1224|Proteobacteria,1RSH6@1236|Gammaproteobacteria,1XP8A@135619|Oceanospirillales	135619|Oceanospirillales	S	Protein of unknown function (DUF2914)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2914
TLS2_k127_1918461_1	886293.Sinac_0926	1.768e-140	462.0	COG3119@1|root,COG3119@2|Bacteria,2IXG7@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
TLS2_k127_1918461_2	690850.Desaf_0959	4.917e-139	453.0	COG2327@1|root,COG2327@2|Bacteria,1R9R8@1224|Proteobacteria,42U55@68525|delta/epsilon subdivisions,2WQGP@28221|Deltaproteobacteria,2MDZ8@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
TLS2_k127_1918461_3	247490.KSU1_D0482	2.295e-99	331.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_1929208_0	234267.Acid_2655	6.797e-144	470.0	COG3669@1|root,COG3669@2|Bacteria,3Y3XG@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glycoside hydrolase, family 29	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
TLS2_k127_1929208_5	234267.Acid_2981	1.674e-56	217.0	COG3609@1|root,COG3609@2|Bacteria,3Y3J8@57723|Acidobacteria	57723|Acidobacteria	K	addiction module antidote protein, CC2985 family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1929208_4	234267.Acid_0468	3.374e-70	251.0	COG1609@1|root,COG1609@2|Bacteria,3Y44C@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_1929208_1	234267.Acid_7008	3.45e-105	358.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_1929208_3	756272.Plabr_3627	4.953e-93	323.0	COG2133@1|root,COG2133@2|Bacteria,2IZH6@203682|Planctomycetes	203682|Planctomycetes	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
TLS2_k127_1929208_2	762903.Pedsa_3617	7.522e-94	313.0	COG1501@1|root,COG1501@2|Bacteria,4NE1H@976|Bacteroidetes,1IQN2@117747|Sphingobacteriia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
TLS2_k127_1941512_2	472759.Nhal_1379	2.522e-69	238.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1S0BH@1236|Gammaproteobacteria,1X076@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS2_k127_1941512_0	379066.GAU_3239	1.857e-103	361.0	COG0840@1|root,COG2972@1|root,COG0840@2|Bacteria,COG2972@2|Bacteria,1ZUEF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
TLS2_k127_1941512_1	234267.Acid_6465	2.629e-98	355.0	COG1629@1|root,COG4771@2|Bacteria,3Y33S@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_1941512_3	74545.EU96_0960	3.274e-53	196.0	COG0221@1|root,COG0221@2|Bacteria	2|Bacteria	C	inorganic diphosphatase activity	-	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	ParBc_2,Pyrophosphatase
TLS2_k127_1941512_4	118168.MC7420_1937	1.369e-28	121.0	2DMJE@1|root,32RYR@2|Bacteria,1G6SI@1117|Cyanobacteria,1HBXF@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of unknown function (DUF4112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4112
TLS2_k127_1945871_16	903818.KI912269_gene341	1.906e-25	110.0	COG0360@1|root,COG0360@2|Bacteria,3Y50N@57723|Acidobacteria	57723|Acidobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
TLS2_k127_1945871_17	648996.Theam_0301	3.278e-24	104.0	COG0238@1|root,COG0238@2|Bacteria,2G49C@200783|Aquificae	200783|Aquificae	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
TLS2_k127_1945871_15	1382359.JIAL01000001_gene1373	8.841e-37	147.0	COG0359@1|root,COG0359@2|Bacteria,3Y4MD@57723|Acidobacteria,2JJAN@204432|Acidobacteriia	204432|Acidobacteriia	J	binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
TLS2_k127_1945871_3	926561.KB900621_gene2762	7.532e-141	461.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,3WANE@53433|Halanaerobiales	186801|Clostridia	L	Replicative DNA helicase	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
TLS2_k127_1945871_9	330214.NIDE2761	3.302e-68	244.0	COG0787@1|root,COG0787@2|Bacteria,3J0JH@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TLS2_k127_1945871_2	269799.Gmet_3277	3.452e-143	467.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,42MG8@68525|delta/epsilon subdivisions,2WJWP@28221|Deltaproteobacteria,43S0X@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
TLS2_k127_1945871_4	204669.Acid345_0189	1.478e-126	413.0	COG4956@1|root,COG4956@2|Bacteria,3Y2RT@57723|Acidobacteria,2JKNZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Large family of predicted nucleotide-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
TLS2_k127_1945871_14	1307759.JOMJ01000004_gene2909	5.923e-39	154.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,42MJ6@68525|delta/epsilon subdivisions,2WJ67@28221|Deltaproteobacteria,2M8C9@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
TLS2_k127_1945871_11	335541.Swol_2360	1.106e-53	194.0	COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,42JZG@68298|Syntrophomonadaceae	186801|Clostridia	F	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
TLS2_k127_1945871_7	525904.Tter_1219	6.858e-76	263.0	COG0483@1|root,COG0483@2|Bacteria,2NP94@2323|unclassified Bacteria	2|Bacteria	G	Inositol monophosphatase	suhB	GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS2_k127_1945871_20	1201293.AKXQ01000009_gene888	3.407e-07	59.0	COG1986@1|root,COG1986@2|Bacteria,1R60T@1224|Proteobacteria,1RNVT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions	yjjX	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0017144,GO:0034641,GO:0042723,GO:0044237,GO:0044281,GO:0046483,GO:0071704,GO:0072527,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	iECO111_1330.ECO111_5255	NTPase_I-T
TLS2_k127_1945871_1	234267.Acid_6644	4.13e-178	580.0	COG0322@1|root,COG0322@2|Bacteria,3Y2Y7@57723|Acidobacteria	57723|Acidobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
TLS2_k127_1945871_18	293826.Amet_0136	1.763e-14	79.0	COG3583@1|root,COG3584@1|root,COG3583@2|Bacteria,COG3584@2|Bacteria,1TTIK@1239|Firmicutes,24997@186801|Clostridia,36DTZ@31979|Clostridiaceae	186801|Clostridia	S	G5 domain protein	yabE	-	-	-	-	-	-	-	-	-	-	-	3D,DUF348,G5
TLS2_k127_1945871_8	720554.Clocl_1424	5.713e-71	253.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,3WGIE@541000|Ruminococcaceae	186801|Clostridia	GJM	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	2.7.7.13,5.4.2.8	ko:K00966,ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I
TLS2_k127_1945871_12	234267.Acid_6304	4.84e-53	195.0	COG0558@1|root,COG0558@2|Bacteria,3Y520@57723|Acidobacteria	57723|Acidobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_1945871_13	335543.Sfum_1996	1.236e-41	159.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2WN4E@28221|Deltaproteobacteria,2MQCK@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
TLS2_k127_1945871_6	247490.KSU1_D0666	5.274e-77	275.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,2IXKU@203682|Planctomycetes	203682|Planctomycetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroD	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
TLS2_k127_1945871_10	1123288.SOV_4c04550	1.601e-54	203.0	COG0083@1|root,COG0083@2|Bacteria,1TRWS@1239|Firmicutes,4H272@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_1945871_5	575540.Isop_1376	4.22e-99	333.0	COG0476@1|root,COG0476@2|Bacteria,2IWVB@203682|Planctomycetes	203682|Planctomycetes	H	involved in molybdopterin and thiamine biosynthesis family 2	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
TLS2_k127_1945871_19	234267.Acid_6420	2.031e-09	67.0	2A6XZ@1|root,30VSX@2|Bacteria,3Y4RH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1945871_0	1267533.KB906733_gene3096	2.581e-191	609.0	COG1215@1|root,COG1215@2|Bacteria,3Y31I@57723|Acidobacteria,2JIKW@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
TLS2_k127_1946276_0	391165.GbCGDNIH1_2254	2.577e-08	66.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TR39@28211|Alphaproteobacteria,2JQFK@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_1960725_2	204669.Acid345_4630	1.61e-74	263.0	COG0577@1|root,COG0577@2|Bacteria,3Y2IG@57723|Acidobacteria,2JHUY@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_1960725_1	204669.Acid345_3531	1.964e-102	346.0	COG0845@1|root,COG0845@2|Bacteria,3Y2F6@57723|Acidobacteria,2JI56@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
TLS2_k127_1960725_0	1499967.BAYZ01000016_gene6550	6.296e-197	625.0	COG2326@1|root,COG2326@2|Bacteria	2|Bacteria	S	polyphosphate kinase activity	pap	-	-	-	-	-	-	-	-	-	-	-	PPK2
TLS2_k127_1968359_1	1232410.KI421422_gene2076	5.103e-91	315.0	COG0739@1|root,COG0739@2|Bacteria,1NESH@1224|Proteobacteria,42MGB@68525|delta/epsilon subdivisions,2WJ7F@28221|Deltaproteobacteria,43T5C@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_1968359_3	32264.tetur05g03370.1	8.782e-05	48.0	KOG2813@1|root,KOG2813@2759|Eukaryota,38B75@33154|Opisthokonta,3BBXS@33208|Metazoa,3CSG9@33213|Bilateria,41ZDD@6656|Arthropoda	33208|Metazoa	O	Protein SSUH2 homolog	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1968359_2	1392498.JQLH01000001_gene2398	8.753e-28	119.0	COG2010@1|root,COG2010@2|Bacteria,4NSE3@976|Bacteroidetes,1I28K@117743|Flavobacteriia,2PHMW@252356|Maribacter	976|Bacteroidetes	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
TLS2_k127_1968359_0	439235.Dalk_2259	1.085e-142	466.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2MHRQ@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,PAS_9,Sigma54_activat
TLS2_k127_1974154_3	1379698.RBG1_1C00001G1850	5.428e-48	182.0	COG0705@1|root,COG0705@2|Bacteria,2NPSK@2323|unclassified Bacteria	2|Bacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS2_k127_1974154_1	1279009.ADICEAN_01064	1.243e-117	395.0	COG4784@1|root,COG4784@2|Bacteria,4PM59@976|Bacteroidetes,47MK2@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS2_k127_1974154_9	330214.NIDE0406	2.309e-21	98.0	COG1959@1|root,COG1959@2|Bacteria	2|Bacteria	K	2 iron, 2 sulfur cluster binding	iscR	-	2.8.1.7	ko:K04487,ko:K13643	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03000,ko03016,ko03029	-	-	-	Rrf2
TLS2_k127_1974154_7	478741.JAFS01000001_gene1529	1.198e-28	118.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,46SGF@74201|Verrucomicrobia,37G6C@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	HP	ThiF family	thiF	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
TLS2_k127_1974154_8	1232410.KI421421_gene3617	2.709e-25	113.0	COG2068@1|root,COG2068@2|Bacteria,1RAAE@1224|Proteobacteria,42QNZ@68525|delta/epsilon subdivisions,2WMYX@28221|Deltaproteobacteria,43V5W@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	HD,NTP_transf_3
TLS2_k127_1974154_6	204669.Acid345_0482	1.192e-33	133.0	COG0316@1|root,COG0316@2|Bacteria,3Y518@57723|Acidobacteria,2JJGN@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TLS2_k127_1974154_10	397948.Cmaq_0517	1.884e-12	72.0	COG0801@1|root,arCOG07203@2157|Archaea	2157|Archaea	H	Dihydroneopterin aldolase	-	-	-	-	-	-	-	-	-	-	-	-	FolB,HPPK
TLS2_k127_1974154_2	204669.Acid345_3437	7.473e-84	284.0	COG2220@1|root,COG2220@2|Bacteria,3Y4RK@57723|Acidobacteria,2JM7M@204432|Acidobacteriia	204432|Acidobacteriia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
TLS2_k127_1974154_5	338966.Ppro_1749	4.306e-35	143.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,42W4B@68525|delta/epsilon subdivisions,2WP0P@28221|Deltaproteobacteria,43UMI@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_1974154_0	404589.Anae109_1669	4.956e-136	447.0	COG2461@1|root,COG2461@2|Bacteria,1R5J5@1224|Proteobacteria,42QAZ@68525|delta/epsilon subdivisions,2WQTR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
TLS2_k127_1974154_4	290397.Adeh_3190	1.545e-42	162.0	COG4309@1|root,COG4309@2|Bacteria,1P367@1224|Proteobacteria,42TEV@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Uncharacterized conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858,DUF2249
TLS2_k127_1976386_2	935863.AWZR01000005_gene2238	5.205e-28	117.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RT11@1236|Gammaproteobacteria,1XCXH@135614|Xanthomonadales	135614|Xanthomonadales	EU	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_1976386_0	1437448.AZRT01000009_gene1017	1.416e-88	304.0	COG3616@1|root,COG3616@2|Bacteria,1N2SF@1224|Proteobacteria,2VFY5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Alanine racemase	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
TLS2_k127_1976386_1	639030.JHVA01000001_gene590	5.375e-45	179.0	COG1629@1|root,COG4771@2|Bacteria,3Y2WI@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_1979672_3	1125699.HMPREF9194_01694	0.0001619	49.0	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_1979672_0	583355.Caka_0206	1.223e-158	511.0	COG0641@1|root,COG0641@2|Bacteria,46TC0@74201|Verrucomicrobia	74201|Verrucomicrobia	C	radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_1979672_1	518766.Rmar_0423	1.439e-106	353.0	COG3622@1|root,COG3622@2|Bacteria,4NG0V@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the hyi family	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_1979672_2	234267.Acid_3783	1.546e-31	138.0	COG5010@1|root,COG5010@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K13486	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Acetyltransf_6,DUF1570,Response_reg,TPR_16,TPR_19
TLS2_k127_1992388_2	573063.Metin_1337	9.303e-22	98.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,23QNU@183939|Methanococci	183939|Methanococci	C	TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit	porC	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
TLS2_k127_1992388_0	1047013.AQSP01000098_gene2570	4.229e-170	550.0	COG4231@1|root,COG4231@2|Bacteria,2NP25@2323|unclassified Bacteria	2|Bacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179,ko:K08941	-	M00598	-	-	br01601,ko00000,ko00002,ko00194,ko01000	-	-	-	POR_N,TPP_enzyme_C
TLS2_k127_1992388_1	1349822.NSB1T_10975	1.438e-52	197.0	COG1014@1|root,COG1014@2|Bacteria,4NGN3@976|Bacteroidetes,2FP78@200643|Bacteroidia,22X20@171551|Porphyromonadaceae	976|Bacteroidetes	C	Indolepyruvate	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
TLS2_k127_1993591_1	118166.JH976538_gene5065	5.948e-45	183.0	COG2202@1|root,COG2203@1|root,COG4585@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07683	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA_3,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_1993591_0	326427.Cagg_3668	2.276e-54	199.0	COG2197@1|root,COG2197@2|Bacteria,2G6PA@200795|Chloroflexi,377BM@32061|Chloroflexia	32061|Chloroflexia	K	Sigma-70, region 4 type 2	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_1997166_2	755732.Fluta_3006	9.89e-28	118.0	COG2391@1|root,COG2391@2|Bacteria,4NM6E@976|Bacteroidetes,1I190@117743|Flavobacteriia	976|Bacteroidetes	S	YeeE YedE family	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
TLS2_k127_1997166_0	1049564.TevJSym_ab00440	2.644e-191	614.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J8SM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Citrate transporter	sac1	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
TLS2_k127_1997166_1	1396141.BATP01000005_gene6008	2.99e-28	123.0	COG4123@1|root,COG4123@2|Bacteria	2|Bacteria	AJ	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)	-	-	-	-	-	-	-	-	-	-	-	-	MTS
TLS2_k127_2001199_0	903818.KI912269_gene149	1.311e-51	207.0	COG4932@1|root,COG4932@2|Bacteria,3Y8E2@57723|Acidobacteria	57723|Acidobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_2001532_0	204669.Acid345_3014	8.567e-159	531.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y64H@57723|Acidobacteria,2JM5F@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
TLS2_k127_2001532_1	545693.BMQ_1531	1.29e-13	75.0	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,4IS7E@91061|Bacilli,1ZS1S@1386|Bacillus	91061|Bacilli	E	methionine gamma-lyase	megL	-	4.4.1.11	ko:K01761	ko00270,ko00450,map00270,map00450	-	R00654,R04770	RC00196,RC00348,RC01209,RC01210	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
TLS2_k127_2002523_3	1121904.ARBP01000013_gene377	3.965e-06	49.0	COG1082@1|root,COG1082@2|Bacteria,4NPBS@976|Bacteroidetes,47Q6G@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_2002523_0	246194.CHY_0120	8.913e-170	545.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,42EK2@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
TLS2_k127_2002523_2	1089553.Tph_c12520	6.042e-34	136.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,42GI5@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
TLS2_k127_2002523_1	313603.FB2170_04530	1.872e-108	362.0	COG0385@1|root,COG0385@2|Bacteria,4NEIM@976|Bacteroidetes,1HY0F@117743|Flavobacteriia,2PGR5@252356|Maribacter	976|Bacteroidetes	S	Sodium Bile acid symporter family	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
TLS2_k127_2007376_0	243231.GSU1485	4.947e-172	567.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NGS@68525|delta/epsilon subdivisions,2WIWF@28221|Deltaproteobacteria,43TQ3@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
TLS2_k127_2007376_1	1121468.AUBR01000016_gene2303	9.354e-117	391.0	COG1921@1|root,COG1921@2|Bacteria,1TQT8@1239|Firmicutes,2498U@186801|Clostridia,42F61@68295|Thermoanaerobacterales	186801|Clostridia	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1,4.3.1.29	ko:K01042,ko:K17468	ko00030,ko00450,ko00970,ko01120,map00030,map00450,map00970,map01120	-	R08219,R10408	RC00544,RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
TLS2_k127_2007376_3	1410658.JHWI01000007_gene532	6.164e-24	104.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,3VRNH@526524|Erysipelotrichia	526524|Erysipelotrichia	K	Cold-shock DNA-binding domain protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_2007376_2	1121335.Clst_2027	1.938e-59	213.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,3WHMW@541000|Ruminococcaceae	186801|Clostridia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS04230	AICARFT_IMPCHas,MGS
TLS2_k127_2008666_1	330214.NIDE3149	1.134e-54	194.0	COG4149@1|root,COG4149@2|Bacteria	2|Bacteria	P	molybdate abc transporter	modB	-	-	ko:K02018,ko:K15496	ko02010,map02010	M00189,M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.5,3.A.1.8	-	-	BPD_transp_1
TLS2_k127_2008666_0	330214.NIDE3152	4.425e-58	216.0	COG0725@1|root,COG0725@2|Bacteria,3J18Z@40117|Nitrospirae	40117|Nitrospirae	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
TLS2_k127_2014519_2	322710.Avin_12950	0.0001095	50.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the peptidase S1C family	degS	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564	-	ko:K04691,ko:K04772	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_2014519_1	742725.HMPREF9450_00985	2.213e-05	57.0	COG1629@1|root,COG4771@2|Bacteria,4NF66@976|Bacteroidetes,2FKYY@200643|Bacteroidia	976|Bacteroidetes	P	Psort location OuterMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_2014519_0	204669.Acid345_4467	1.056e-60	218.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria,2JIG4@204432|Acidobacteriia	204432|Acidobacteriia	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2020907_3	661478.OP10G_2992	1.403e-15	87.0	COG4537@1|root,COG4537@2|Bacteria	2|Bacteria	U	Required for transformation and DNA binding	comGC	GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944	-	ko:K02245,ko:K02456	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
TLS2_k127_2020907_0	1396141.BATP01000035_gene4106	3.273e-145	505.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,46UAE@74201|Verrucomicrobia,2IV44@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_12,WD40
TLS2_k127_2020907_2	452637.Oter_2422	6.98e-31	124.0	COG1595@1|root,COG1595@2|Bacteria,46VAN@74201|Verrucomicrobia	74201|Verrucomicrobia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_2020907_4	886293.Sinac_4026	2.274e-15	79.0	COG1595@1|root,COG1595@2|Bacteria,2IZ8A@203682|Planctomycetes	203682|Planctomycetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_2020907_1	1123242.JH636435_gene2023	2.17e-38	150.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_2032930_3	861299.J421_6359	4.529e-52	192.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6359|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2032930_1	1499967.BAYZ01000177_gene5729	3.318e-141	452.0	COG0207@1|root,COG0207@2|Bacteria	2|Bacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
TLS2_k127_2032930_0	452637.Oter_0169	1.885e-189	612.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	GH97_C,GH97_N,Glyco_hydro_97
TLS2_k127_2032930_2	251221.35211983	1.475e-118	405.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_2041157_0	1089547.KB913013_gene998	4.499e-120	392.0	COG1520@1|root,COG1520@2|Bacteria,4NK4X@976|Bacteroidetes,47KWI@768503|Cytophagia	976|Bacteroidetes	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2041157_1	42256.RradSPS_0609	1.359e-55	199.0	COG0288@1|root,COG0288@2|Bacteria,2GM1M@201174|Actinobacteria,4CSPT@84995|Rubrobacteria	84995|Rubrobacteria	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS2_k127_2041157_2	1502851.FG93_03317	2.08e-17	89.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TVTA@28211|Alphaproteobacteria,3JUN2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	2.6.1.102,2.6.1.109	ko:K13010,ko:K19715	ko00520,map00520	-	R10460,R11395	RC00006,RC00160,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_2044938_0	1047013.AQSP01000133_gene2141	2.331e-167	536.0	COG2605@1|root,COG2605@2|Bacteria	2|Bacteria	G	GHMP kinase	fkp	-	2.7.1.52	ko:K05305	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R03161	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Fucokinase,GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_2044938_2	398767.Glov_1011	4.316e-105	353.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2WIVS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3198	AA_kinase,PUA
TLS2_k127_2044938_1	1379281.AVAG01000007_gene1209	5.782e-126	417.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,42ME0@68525|delta/epsilon subdivisions,2WJB8@28221|Deltaproteobacteria,2M85F@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_2044938_3	290397.Adeh_2106	9.566e-96	320.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2WM7V@28221|Deltaproteobacteria,2Z1U0@29|Myxococcales	28221|Deltaproteobacteria	P	Dimerisation domain of Zinc Transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TLS2_k127_2048042_5	671143.DAMO_2498	7.035e-16	78.0	COG1180@1|root,COG1180@2|Bacteria,2NP82@2323|unclassified Bacteria	2|Bacteria	O	Radical SAM superfamily	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
TLS2_k127_2048042_3	1267535.KB906767_gene3948	1.471e-61	228.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_2048042_0	1267535.KB906767_gene3947	5.271e-88	298.0	COG4821@1|root,COG4821@2|Bacteria	2|Bacteria	S	SIS domain	-	-	-	-	-	-	-	-	-	-	-	-	SIS_2
TLS2_k127_2048042_4	1267535.KB906767_gene3946	2.401e-42	166.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HTH_24,MarR,ROK
TLS2_k127_2048042_1	1267535.KB906767_gene4827	2.481e-80	277.0	COG0077@1|root,COG0077@2|Bacteria,3Y49H@57723|Acidobacteria,2JJ3X@204432|Acidobacteriia	204432|Acidobacteriia	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
TLS2_k127_2048042_2	247634.GPB2148_1664	5.59e-79	272.0	COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,1RSCG@1236|Gammaproteobacteria,1J4W0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC,Radical_SAM
TLS2_k127_2070659_0	102129.Lepto7375DRAFT_7693	5.303e-62	215.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_2070659_2	314278.NB231_16448	5.34e-26	110.0	2DSUP@1|root,33HGU@2|Bacteria	2|Bacteria	-	-	-	GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2070659_1	314278.NB231_16453	1.216e-32	128.0	COG1848@1|root,COG1848@2|Bacteria,1RK9K@1224|Proteobacteria,1SBYF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_2072831_2	1382359.JIAL01000001_gene380	1.49e-94	315.0	COG0501@1|root,COG0501@2|Bacteria,3Y3EZ@57723|Acidobacteria,2JIIZ@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS2_k127_2072831_8	401526.TcarDRAFT_1252	2.87e-17	89.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4H4K0@909932|Negativicutes	909932|Negativicutes	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS2_k127_2072831_6	1157490.EL26_17245	7.977e-41	161.0	COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,4HII3@91061|Bacilli,279RN@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08510	CoaE
TLS2_k127_2072831_1	573370.DMR_42920	4.47e-115	375.0	COG1216@1|root,COG1216@2|Bacteria,1R50T@1224|Proteobacteria,42P74@68525|delta/epsilon subdivisions,2WK88@28221|Deltaproteobacteria,2MANJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_23
TLS2_k127_2072831_7	234267.Acid_6300	5.237e-40	159.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_25,Methyltransf_31,TehB
TLS2_k127_2072831_4	215803.DB30_4323	1.397e-45	176.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42P5W@68525|delta/epsilon subdivisions,2WMA6@28221|Deltaproteobacteria,2YWSU@29|Myxococcales	28221|Deltaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_2072831_5	1121374.KB891575_gene861	2.883e-41	158.0	COG3193@1|root,COG3193@2|Bacteria,1RB2H@1224|Proteobacteria,1S5K1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein possibly involved in utilization of glycolate and propanediol	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
TLS2_k127_2072831_0	472759.Nhal_2902	9.648e-167	538.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
TLS2_k127_2072831_3	246197.MXAN_6337	1.061e-67	233.0	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,43B0A@68525|delta/epsilon subdivisions,2X6EE@28221|Deltaproteobacteria,2YUMP@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase	leuB2	-	1.1.1.41,1.1.1.85	ko:K00030,ko:K00052	ko00020,ko00290,ko00660,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00660,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00432,M00535	R00709,R00994,R04426,R10052	RC00084,RC00114,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_2077414_0	469383.Cwoe_1088	2.552e-170	544.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4CPID@84995|Rubrobacteria	84995|Rubrobacteria	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS2_k127_2077414_3	756272.Plabr_3368	2.396e-71	250.0	COG0363@1|root,COG0363@2|Bacteria,2IYJ5@203682|Planctomycetes	203682|Planctomycetes	G	6-phosphogluconolactonase glucosamine-6-phosphate isomerase deaminase	-	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso
TLS2_k127_2077414_2	869210.Marky_1160	2.631e-80	278.0	COG0685@1|root,COG0685@2|Bacteria,1WI80@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	5,10-methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS2_k127_2077414_6	938293.CAJU020000016_gene1705	1.374e-27	115.0	COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,24MRS@186801|Clostridia,22HNF@1570339|Peptoniphilaceae	186801|Clostridia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
TLS2_k127_2077414_4	639030.JHVA01000001_gene2413	8.512e-37	139.0	COG0211@1|root,COG0211@2|Bacteria,3Y5D8@57723|Acidobacteria,2JJPG@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
TLS2_k127_2077414_1	429009.Adeg_0185	1.217e-121	399.0	COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,42F3Z@68295|Thermoanaerobacterales	186801|Clostridia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
TLS2_k127_2077414_5	1121423.JONT01000001_gene1942	1.561e-33	139.0	COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,24JFM@186801|Clostridia,261W4@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_2077414_7	204669.Acid345_0022	6.715e-26	111.0	COG0799@1|root,COG0799@2|Bacteria,3Y5SD@57723|Acidobacteria,2JJ9Z@204432|Acidobacteriia	204432|Acidobacteriia	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
TLS2_k127_2079043_1	404589.Anae109_3957	2.198e-97	331.0	COG0312@1|root,COG0312@2|Bacteria,1RBJZ@1224|Proteobacteria,42YBE@68525|delta/epsilon subdivisions,2WUP7@28221|Deltaproteobacteria,2YZ4Y@29|Myxococcales	28221|Deltaproteobacteria	L	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS2_k127_2079043_5	443143.GM18_2685	2.142e-54	195.0	COG4119@1|root,COG4119@2|Bacteria,1RHCE@1224|Proteobacteria,431WB@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_2079043_4	1430331.EP10_18360	3.962e-69	244.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,4HABP@91061|Bacilli,1WE42@129337|Geobacillus	91061|Bacilli	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_2079043_3	595494.Tola_1754	4.742e-85	296.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1RPGK@1236|Gammaproteobacteria,1Y61V@135624|Aeromonadales	135624|Aeromonadales	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TLS2_k127_2079043_0	886293.Sinac_1335	1.174e-99	330.0	COG1413@1|root,COG1413@2|Bacteria,2IYWU@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_2079043_2	913865.DOT_6169	5.33e-89	302.0	COG0697@1|root,COG0697@2|Bacteria,1V1H0@1239|Firmicutes,24BBW@186801|Clostridia	186801|Clostridia	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_2079043_6	1267535.KB906767_gene4959	0.0001088	45.0	COG0859@1|root,COG0859@2|Bacteria,3Y7R7@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
TLS2_k127_2092474_6	269797.Mbar_A1046	4.188e-51	197.0	COG1668@1|root,arCOG01462@2157|Archaea,2XX4X@28890|Euryarchaeota,2NAR7@224756|Methanomicrobia	224756|Methanomicrobia	C	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_2092474_4	269797.Mbar_A1047	6.55e-72	258.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUT0@28890|Euryarchaeota,2NAN6@224756|Methanomicrobia	224756|Methanomicrobia	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_2092474_3	379066.GAU_2128	2.755e-89	315.0	COG0591@1|root,COG0591@2|Bacteria,1ZUAP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Sodium:solute symporter family	-	-	-	ko:K14392	-	-	-	-	ko00000,ko02000	2.A.21.1	-	-	SSF
TLS2_k127_2092474_8	1304883.KI912532_gene206	0.0002864	53.0	COG1073@1|root,COG1073@2|Bacteria,1MY4C@1224|Proteobacteria,2WEH2@28216|Betaproteobacteria,2KUPJ@206389|Rhodocyclales	206389|Rhodocyclales	S	BAAT Acyl-CoA thioester hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TLS2_k127_2092474_2	1340493.JNIF01000004_gene816	5.552e-209	659.0	COG0043@1|root,COG0043@2|Bacteria,3Y3BY@57723|Acidobacteria	57723|Acidobacteria	H	Belongs to the UbiD family	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
TLS2_k127_2092474_1	1121904.ARBP01000001_gene5918	3.092e-213	694.0	COG3250@1|root,COG3250@2|Bacteria,4NGZH@976|Bacteroidetes,47M3M@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
TLS2_k127_2092474_7	459495.SPLC1_S501220	8.775e-05	55.0	COG1413@1|root,COG1413@2|Bacteria,1G511@1117|Cyanobacteria,1HATT@1150|Oscillatoriales	1117|Cyanobacteria	C	HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
TLS2_k127_2092474_0	1123008.KB905699_gene1915	6.259e-219	698.0	COG1164@1|root,COG1164@2|Bacteria,4NFV3@976|Bacteroidetes,2FMG8@200643|Bacteroidia,22XF5@171551|Porphyromonadaceae	976|Bacteroidetes	E	Oligoendopeptidase f	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2092474_5	1123368.AUIS01000009_gene2452	1.3e-57	205.0	COG0739@1|root,COG0739@2|Bacteria,1RK0U@1224|Proteobacteria,1S6P9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Peptidase family M23	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
TLS2_k127_2098169_2	234267.Acid_4908	1.178e-106	353.0	COG0673@1|root,COG0673@2|Bacteria,3Y6XR@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_2098169_3	1267535.KB906767_gene1317	3.385e-96	324.0	COG1082@1|root,COG1082@2|Bacteria,3Y72F@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_2098169_1	1210884.HG799463_gene9569	8.781e-123	411.0	COG3356@1|root,COG3356@2|Bacteria,2IXKA@203682|Planctomycetes	203682|Planctomycetes	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
TLS2_k127_2098169_0	1396418.BATQ01000049_gene423	2.656e-188	602.0	COG3356@1|root,COG3356@2|Bacteria,46UGT@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2098169_4	401053.AciPR4_0496	6.282e-14	75.0	COG0673@1|root,COG0673@2|Bacteria,3Y4KS@57723|Acidobacteria,2JM5G@204432|Acidobacteriia	204432|Acidobacteriia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_209956_2	886293.Sinac_7174	6.682e-28	120.0	COG2716@1|root,COG2716@2|Bacteria	2|Bacteria	E	regulation of RNA biosynthetic process	gcvR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
TLS2_k127_209956_1	278957.ABEA03000193_gene1036	3.201e-86	293.0	COG1028@1|root,COG1028@2|Bacteria,46TD2@74201|Verrucomicrobia,3K7W5@414999|Opitutae	414999|Opitutae	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_209956_0	1267535.KB906767_gene5172	2.744e-145	466.0	COG4225@1|root,COG4225@2|Bacteria,3Y6Y6@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyl Hydrolase Family 88	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
TLS2_k127_2109680_0	56780.SYN_01000	1.847e-67	236.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QSI@68525|delta/epsilon subdivisions,2WMNJ@28221|Deltaproteobacteria,2MQC2@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
TLS2_k127_2109680_1	584708.Apau_2007	5.344e-45	176.0	COG1477@1|root,COG1477@2|Bacteria,3TAWQ@508458|Synergistetes	508458|Synergistetes	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
TLS2_k127_2109680_2	1121904.ARBP01000006_gene4028	8.977e-13	80.0	295NE@1|root,2ZSZT@2|Bacteria,4NPQK@976|Bacteroidetes	976|Bacteroidetes	S	DoxX	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
TLS2_k127_2110358_2	452637.Oter_1254	5.325e-113	373.0	COG0519@1|root,COG0519@2|Bacteria,46SIW@74201|Verrucomicrobia,3K77S@414999|Opitutae	2|Bacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
TLS2_k127_2110358_0	404589.Anae109_3441	6.319e-225	715.0	COG4690@1|root,COG4690@2|Bacteria,1R4YQ@1224|Proteobacteria,42NQZ@68525|delta/epsilon subdivisions,2WMGS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM peptidase U34 dipeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C69
TLS2_k127_2110358_1	452637.Oter_2196	1.424e-140	460.0	COG0673@1|root,COG0673@2|Bacteria,46U95@74201|Verrucomicrobia,3K969@414999|Opitutae	414999|Opitutae	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_2110358_3	1169143.KB911045_gene3325	6.379e-51	196.0	COG2202@1|root,COG4192@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4192@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VM3J@28216|Betaproteobacteria,1KHSA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3,PAS_4,PAS_8,PAS_9
TLS2_k127_2114026_0	1185876.BN8_04332	5.425e-216	700.0	COG2866@1|root,COG2866@2|Bacteria,4NF3D@976|Bacteroidetes,47UEQ@768503|Cytophagia	976|Bacteroidetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS2_k127_2115041_0	204669.Acid345_1488	1.078e-129	445.0	COG2844@1|root,COG2844@2|Bacteria,3Y2FJ@57723|Acidobacteria,2JI19@204432|Acidobacteriia	204432|Acidobacteriia	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	DUF294,GlnD_UR_UTase,HD
TLS2_k127_2115041_1	1121403.AUCV01000027_gene2512	5.573e-38	146.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,42SJJ@68525|delta/epsilon subdivisions,2WP4E@28221|Deltaproteobacteria,2MK8A@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
TLS2_k127_2125017_2	1232410.KI421421_gene3422	4.528e-90	308.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,42MU0@68525|delta/epsilon subdivisions,2WJW5@28221|Deltaproteobacteria,43UU9@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
TLS2_k127_2125017_0	1232410.KI421421_gene3421	0.0	1043.0	2E1I6@1|root,32WW2@2|Bacteria,1NTI4@1224|Proteobacteria,42YDB@68525|delta/epsilon subdivisions,2WTNY@28221|Deltaproteobacteria,43TFS@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MtrB_PioB
TLS2_k127_2125017_1	1232410.KI421421_gene3420	1.114e-140	448.0	COG3303@1|root,COG3303@2|Bacteria,1R0AQ@1224|Proteobacteria,43CT6@68525|delta/epsilon subdivisions,2X80R@28221|Deltaproteobacteria,43VYX@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Cytochrome c3	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
TLS2_k127_2126035_5	234267.Acid_6769	3.331e-14	80.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_2126035_0	383372.Rcas_3813	8.643e-94	324.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	stsA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0043170,GO:0044238,GO:0071704,GO:1901576	2.6.1.109	ko:K19715	-	-	R11395	RC00160	ko00000,ko01000,ko01005	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_2126035_3	702113.PP1Y_Mpl7589	2.161e-41	164.0	COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,2TSVI@28211|Alphaproteobacteria,2K5HP@204457|Sphingomonadales	204457|Sphingomonadales	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_2126035_2	1408424.JHYI01000025_gene1765	3.428e-66	242.0	COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,4HDE3@91061|Bacilli,1ZC4Y@1386|Bacillus	91061|Bacilli	GK	ROK family	xylR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK
TLS2_k127_2126035_1	1033743.CAES01000001_gene1711	2.11e-71	248.0	COG2120@1|root,COG2120@2|Bacteria,1TUFR@1239|Firmicutes,4I855@91061|Bacilli,26YXG@186822|Paenibacillaceae	91061|Bacilli	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_2126035_4	935845.JADQ01000002_gene802	7.355e-23	109.0	COG2017@1|root,COG2017@2|Bacteria,1TQVE@1239|Firmicutes,4HFJM@91061|Bacilli,26U0H@186822|Paenibacillaceae	91061|Bacilli	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	Aldose_epim,DUF4432
TLS2_k127_2137207_2	1128427.KB904821_gene4030	1.584e-68	239.0	COG1615@1|root,COG1615@2|Bacteria,1G05D@1117|Cyanobacteria,1H8E1@1150|Oscillatoriales	1117|Cyanobacteria	S	UPF0182 protein	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
TLS2_k127_2137207_3	1340493.JNIF01000003_gene1658	3.863e-31	124.0	COG0316@1|root,COG0316@2|Bacteria,3Y4ZB@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TLS2_k127_2137207_0	765420.OSCT_2785	2.083e-105	353.0	COG1181@1|root,COG1181@2|Bacteria,2G5RS@200795|Chloroflexi,3750N@32061|Chloroflexia	32061|Chloroflexia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TLS2_k127_2137207_1	1382359.JIAL01000001_gene624	2.053e-97	324.0	COG0010@1|root,COG0010@2|Bacteria,3Y46E@57723|Acidobacteria,2JIPY@204432|Acidobacteriia	204432|Acidobacteriia	E	Arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS2_k127_2137911_0	338966.Ppro_1345	5.748e-204	639.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,42MGN@68525|delta/epsilon subdivisions,2WJET@28221|Deltaproteobacteria,43T0C@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	amino acid-binding ACT domain protein	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
TLS2_k127_2137911_2	338966.Ppro_1346	2.009e-134	434.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,42MH0@68525|delta/epsilon subdivisions,2WRNN@28221|Deltaproteobacteria,43TA8@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
TLS2_k127_2137911_1	338966.Ppro_1347	2.724e-201	634.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,42N01@68525|delta/epsilon subdivisions,2WKJQ@28221|Deltaproteobacteria,43TXZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TLS2_k127_2137911_3	338966.Ppro_1348	6.847e-87	292.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,42STI@68525|delta/epsilon subdivisions,2WP1K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
TLS2_k127_2137911_4	338966.Ppro_1349	9.21e-34	131.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,42MJK@68525|delta/epsilon subdivisions,2WJ8V@28221|Deltaproteobacteria,43SW9@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,UbiA
TLS2_k127_2145923_0	1283300.ATXB01000001_gene774	3.336e-160	530.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RPRP@1236|Gammaproteobacteria,1XDVS@135618|Methylococcales	135618|Methylococcales	C	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS2_k127_2145923_1	649349.Lbys_0650	1.387e-123	411.0	COG2866@1|root,COG2866@2|Bacteria,4NH4I@976|Bacteroidetes,47MEA@768503|Cytophagia	976|Bacteroidetes	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS2_k127_2154262_6	761193.Runsl_4067	3.697e-34	134.0	COG1082@1|root,COG1082@2|Bacteria,4NFS5@976|Bacteroidetes,47NAA@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_2154262_4	1267535.KB906767_gene4993	4.989e-71	243.0	COG0652@1|root,COG0652@2|Bacteria,3Y4CX@57723|Acidobacteria,2JJ67@204432|Acidobacteriia	204432|Acidobacteriia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
TLS2_k127_2154262_5	1121920.AUAU01000026_gene1478	9.322e-41	155.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_2154262_3	1191523.MROS_2095	1.093e-82	286.0	COG0646@1|root,COG0646@2|Bacteria	2|Bacteria	E	methionine synthase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
TLS2_k127_2154262_0	246194.CHY_1224	1.133e-151	501.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,42F3G@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
TLS2_k127_2154262_1	335543.Sfum_2564	5.351e-107	365.0	COG1456@1|root,COG1456@2|Bacteria,1R4RE@1224|Proteobacteria,42M89@68525|delta/epsilon subdivisions,2WJVQ@28221|Deltaproteobacteria,2MR7F@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	CO dehydrogenase acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
TLS2_k127_2154262_2	574087.Acear_1300	8.837e-86	301.0	COG2069@1|root,COG2069@2|Bacteria,1TSSY@1239|Firmicutes,24BVJ@186801|Clostridia	186801|Clostridia	C	CO dehydrogenase acetyl-CoA synthase delta subunit	acsD	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
TLS2_k127_2158552_1	28072.Nos7524_4523	3.503e-10	67.0	COG1876@1|root,COG1876@2|Bacteria,1G4P0@1117|Cyanobacteria,1HIMP@1161|Nostocales	1117|Cyanobacteria	M	peptidase M15B and M15C DD-carboxypeptidase VanY	-	-	-	-	-	-	-	-	-	-	-	-	VanY
TLS2_k127_2158552_0	886293.Sinac_3736	1.123e-17	91.0	COG2165@1|root,COG2165@2|Bacteria,2J1QS@203682|Planctomycetes	203682|Planctomycetes	NU	TIGRFAM prepilin-type N-terminal cleavage methylation domain	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
TLS2_k127_2171237_1	330214.NIDE1059	5.066e-46	179.0	COG0404@1|root,COG0404@2|Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	1.5.99.5,2.1.2.10	ko:K00605,ko:K06980,ko:K22086	ko00260,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200	M00532	R00609,R01221,R02300,R04125	RC00022,RC00069,RC00183,RC00190,RC00557,RC02834	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	GCV_T,GCV_T_C
TLS2_k127_2171237_2	1033738.CAEP01000078_gene2898	8.193e-05	51.0	COG0457@1|root,COG0457@2|Bacteria,1V3U6@1239|Firmicutes,4HFWW@91061|Bacilli,26FJY@186818|Planococcaceae	91061|Bacilli	S	Tetratrico peptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_5,TPR_6,TPR_8
TLS2_k127_2171237_0	8128.ENSONIP00000015586	5.799e-113	373.0	COG0021@1|root,KOG0523@2759|Eukaryota,38B8B@33154|Opisthokonta,3BG4D@33208|Metazoa,3CXK5@33213|Bilateria,484SM@7711|Chordata,48VMD@7742|Vertebrata,49W26@7898|Actinopterygii	33208|Metazoa	G	Transketolase b	TKTL2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031935,GO:0033043,GO:0033044,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0060968,GO:0065007,GO:0080090,GO:1902275,GO:1903506,GO:2000112,GO:2001141	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TLS2_k127_2175152_1	545695.TREAZ_2789	1.23e-08	66.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_2175152_0	762903.Pedsa_1099	5.129e-30	134.0	COG4409@1|root,COG4409@2|Bacteria,4NIWA@976|Bacteroidetes	976|Bacteroidetes	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_2177938_1	1173022.Cri9333_2006	1.118e-48	180.0	COG4122@1|root,COG4122@2|Bacteria,1GBCN@1117|Cyanobacteria,1HEQZ@1150|Oscillatoriales	1117|Cyanobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2177938_0	439235.Dalk_0380	3.247e-91	317.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,42NWZ@68525|delta/epsilon subdivisions,2WJU7@28221|Deltaproteobacteria,2MJ2C@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS2_k127_2179327_0	234267.Acid_1201	5.054e-252	790.0	COG3591@1|root,COG3591@2|Bacteria,3Y2TU@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
TLS2_k127_2179327_1	247490.KSU1_B0488	1.123e-100	335.0	COG0433@1|root,COG0561@1|root,COG0433@2|Bacteria,COG0561@2|Bacteria,2IXQK@203682|Planctomycetes	203682|Planctomycetes	S	Sucrose-6F-phosphate phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF87,Hydrolase_3
TLS2_k127_2179518_1	644968.DFW101_2128	5.519e-107	354.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,42MKI@68525|delta/epsilon subdivisions,2WM5H@28221|Deltaproteobacteria,2MEEN@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Domain of unknown function (DUF3459)	treZ-2	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
TLS2_k127_2179518_0	234267.Acid_0217	1.693e-221	701.0	COG3408@1|root,COG3408@2|Bacteria,3Y6VF@57723|Acidobacteria	57723|Acidobacteria	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
TLS2_k127_2179839_10	573061.Clocel_1169	1.733e-14	76.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,36EH8@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter, ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_2179839_3	639030.JHVA01000001_gene305	2.884e-87	307.0	COG4591@1|root,COG4591@2|Bacteria,3Y3BU@57723|Acidobacteria,2JIC6@204432|Acidobacteriia	204432|Acidobacteriia	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
TLS2_k127_2179839_1	1267533.KB906738_gene2114	1.605e-185	594.0	COG1190@1|root,COG1190@2|Bacteria,3Y3N0@57723|Acidobacteria,2JI1W@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
TLS2_k127_2179839_8	926566.Terro_3751	1.974e-33	134.0	COG0781@1|root,COG0781@2|Bacteria,3Y4Z7@57723|Acidobacteria,2JJFX@204432|Acidobacteriia	204432|Acidobacteriia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
TLS2_k127_2179839_6	436114.SYO3AOP1_1285	2.12e-50	185.0	COG0054@1|root,COG0054@2|Bacteria,2G3YV@200783|Aquificae	200783|Aquificae	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
TLS2_k127_2179839_4	1121918.ARWE01000001_gene3092	5.613e-86	291.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,42QPM@68525|delta/epsilon subdivisions,2WMRG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS2_k127_2179839_9	671143.DAMO_1207	1.927e-32	133.0	COG0558@1|root,COG0558@2|Bacteria,2NRJN@2323|unclassified Bacteria	2|Bacteria	I	CDP-alcohol phosphatidyltransferase	MA20_28295	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_2179839_5	344747.PM8797T_23639	8.854e-70	248.0	COG1477@1|root,COG1477@2|Bacteria,2IY0F@203682|Planctomycetes	203682|Planctomycetes	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
TLS2_k127_2179839_0	2074.JNYD01000019_gene2455	2.777e-229	719.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4DX7A@85010|Pseudonocardiales	201174|Actinobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS2_k127_2179839_2	269799.Gmet_1677	5.95e-176	566.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42N1B@68525|delta/epsilon subdivisions,2WJWS@28221|Deltaproteobacteria,43UDG@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM FAD dependent oxidoreductase	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TLS2_k127_2179839_7	666685.R2APBS1_3313	6.422e-39	164.0	COG3115@1|root,COG3712@1|root,COG3115@2|Bacteria,COG3712@2|Bacteria,1N941@1224|Proteobacteria,1T50J@1236|Gammaproteobacteria,1X4SP@135614|Xanthomonadales	135614|Xanthomonadales	DPT	cell septum assembly	-	-	-	-	-	-	-	-	-	-	-	-	FecR
TLS2_k127_2194709_1	1250278.JQNQ01000001_gene2008	9.16e-40	150.0	28I5V@1|root,2Z891@2|Bacteria,4NF4U@976|Bacteroidetes,1HZRH@117743|Flavobacteriia	976|Bacteroidetes	G	Cellulase N-terminal ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,Glyco_hydro_9
TLS2_k127_2194709_0	1168034.FH5T_07165	6.2e-95	323.0	COG0613@1|root,COG0613@2|Bacteria,4NHZ5@976|Bacteroidetes,2FQW5@200643|Bacteroidia	976|Bacteroidetes	G	Domain of unknown function	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	DUF5001,PHP
TLS2_k127_2194709_2	309807.SRU_0976	7.24e-37	150.0	COG0729@1|root,COG0729@2|Bacteria,4PF0B@976|Bacteroidetes,1FJXS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
TLS2_k127_2212733_0	1123253.AUBD01000002_gene1267	3.613e-50	197.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,1SDNN@1236|Gammaproteobacteria,1X44C@135614|Xanthomonadales	135614|Xanthomonadales	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
TLS2_k127_2212733_2	1267535.KB906767_gene2743	1.224e-10	74.0	COG3409@1|root,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	Glyco_hydro_25,PG_binding_1
TLS2_k127_2212733_1	240015.ACP_0992	5.7e-28	119.0	COG0457@1|root,COG0457@2|Bacteria	240015.ACP_0992|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_22328_1	313628.LNTAR_05609	3.228e-90	302.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_22328_0	479435.Kfla_1921	1.032e-135	456.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,FAD_oxidored,Fer4,NAD_binding_8,Pyr_redox_2
TLS2_k127_22328_2	234267.Acid_3225	1.214e-07	55.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_8,Trans_reg_C
TLS2_k127_223825_2	65093.PCC7418_3763	5.651e-81	283.0	COG1503@1|root,COG1503@2|Bacteria,1GADA@1117|Cyanobacteria	1117|Cyanobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_223825_3	706587.Desti_1071	1.696e-20	97.0	COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria,2MQN7@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM Universal stress protein family	usp-2	-	-	ko:K06149	-	-	-	-	ko00000	-	-	-	Usp
TLS2_k127_223825_1	765952.PUV_02700	1.112e-215	684.0	COG1960@1|root,COG1960@2|Bacteria,2JFR3@204428|Chlamydiae	204428|Chlamydiae	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_223825_0	765952.PUV_02690	5.597e-232	729.0	COG4799@1|root,COG4799@2|Bacteria,2JFTC@204428|Chlamydiae	204428|Chlamydiae	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
TLS2_k127_2257107_0	272134.KB731324_gene2111	2.675e-90	314.0	COG1972@1|root,COG1972@2|Bacteria,1G3CA@1117|Cyanobacteria,1H7FT@1150|Oscillatoriales	1117|Cyanobacteria	F	PFAM Na dependent nucleoside transporter	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Nucleos_tra2_C,Nucleos_tra2_N
TLS2_k127_2257107_1	926550.CLDAP_05300	1.066e-59	209.0	COG1225@1|root,COG1225@2|Bacteria,2G6TX@200795|Chloroflexi	200795|Chloroflexi	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS2_k127_2275997_0	330214.NIDE0751	2.752e-198	625.0	COG0017@1|root,COG0017@2|Bacteria	2|Bacteria	J	Asparaginyl-tRNA synthetase	asnS	GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
TLS2_k127_2275997_2	706587.Desti_1483	9.549e-43	170.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,42TUJ@68525|delta/epsilon subdivisions,2WQ4U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	phosphotransferase related to Ser Thr protein kinases	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
TLS2_k127_2275997_1	1144275.COCOR_06047	3.473e-48	185.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,42SI2@68525|delta/epsilon subdivisions,2WQPV@28221|Deltaproteobacteria,2YVRY@29|Myxococcales	28221|Deltaproteobacteria	JM	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_2275997_3	903818.KI912269_gene350	1.485e-17	86.0	COG1437@1|root,COG1437@2|Bacteria,3Y4V3@57723|Acidobacteria	57723|Acidobacteria	F	CYTH	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
TLS2_k127_2280521_0	404589.Anae109_2392	1.988e-186	635.0	COG0454@1|root,COG1022@1|root,COG0456@2|Bacteria,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
TLS2_k127_2280521_6	234267.Acid_7441	2.099e-40	162.0	COG1216@1|root,COG1216@2|Bacteria,3Y7JI@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
TLS2_k127_2280521_4	1267535.KB906767_gene3847	6.56e-69	249.0	COG1216@1|root,COG1216@2|Bacteria,3Y7CJ@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_2280521_3	318464.IO99_05130	2.235e-89	307.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,36DHM@31979|Clostridiaceae	186801|Clostridia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TLS2_k127_2280521_2	234267.Acid_1486	3.171e-132	431.0	COG0182@1|root,COG0182@2|Bacteria,3Y2TR@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
TLS2_k127_2280521_5	1499967.BAYZ01000010_gene5199	4.82e-50	191.0	COG1091@1|root,COG1091@2|Bacteria,2NPG4@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
TLS2_k127_2280521_1	945713.IALB_2724	1.023e-153	493.0	COG2192@1|root,COG2192@2|Bacteria	2|Bacteria	O	nodulation	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TLS2_k127_2281921_1	1499967.BAYZ01000170_gene5483	1.284e-73	263.0	COG0612@1|root,COG0612@2|Bacteria,2NP5H@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_2281921_3	1121396.KB893092_gene3360	5.213e-27	124.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2WNZS@28221|Deltaproteobacteria,2MJUT@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
TLS2_k127_2281921_0	1267533.KB906736_gene1274	1.179e-76	281.0	COG2208@1|root,COG2770@1|root,COG2208@2|Bacteria,COG2770@2|Bacteria,3Y2P9@57723|Acidobacteria,2JIVP@204432|Acidobacteriia	204432|Acidobacteriia	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
TLS2_k127_2281921_2	555088.DealDRAFT_2219	1.095e-63	229.0	COG1015@1|root,COG1015@2|Bacteria,1UJAM@1239|Firmicutes,25EZP@186801|Clostridia	186801|Clostridia	C	Metalloenzyme superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme
TLS2_k127_2281921_4	1499967.BAYZ01000061_gene5954	1.76e-12	69.0	COG1533@1|root,COG1533@2|Bacteria,2NPZ9@2323|unclassified Bacteria	2|Bacteria	L	DNA photolyase activity	-	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
TLS2_k127_2286803_2	1278073.MYSTI_04042	1.526e-31	135.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
TLS2_k127_2286803_0	344747.PM8797T_26465	4.373e-128	420.0	COG2706@1|root,COG2706@2|Bacteria,2IY02@203682|Planctomycetes	203682|Planctomycetes	G	COG2706 3-carboxymuconate cyclase	-	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactonase
TLS2_k127_2286803_1	234267.Acid_1441	2.157e-78	271.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS2_k127_2303913_6	794903.OPIT5_15555	2.422e-13	74.0	2DHIW@1|root,2ZZZR@2|Bacteria,46WA6@74201|Verrucomicrobia	794903.OPIT5_15555|-	S	Heparinase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2303913_1	1047013.AQSP01000130_gene1863	8.775e-73	263.0	28KQH@1|root,2ZA8A@2|Bacteria	2|Bacteria	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TLS2_k127_2303913_0	344747.PM8797T_29862	5.137e-73	258.0	COG1082@1|root,COG1082@2|Bacteria,2J0ZG@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_2303913_7	765911.Thivi_3373	7.425e-10	68.0	COG0741@1|root,COG0741@2|Bacteria,1RFDI@1224|Proteobacteria,1S52B@1236|Gammaproteobacteria,1WW2X@135613|Chromatiales	135613|Chromatiales	M	Soluble lytic murein transglycosylase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TLS2_k127_2303913_3	1267535.KB906767_gene341	1.997e-49	183.0	28JRZ@1|root,2Z9HI@2|Bacteria,3Y7HD@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
TLS2_k127_2303913_2	234267.Acid_3571	1.422e-64	228.0	COG0558@1|root,COG0558@2|Bacteria,3Y4PW@57723|Acidobacteria	57723|Acidobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
TLS2_k127_2303913_5	234267.Acid_3570	1.62e-18	94.0	COG2246@1|root,COG2246@2|Bacteria,3Y5HC@57723|Acidobacteria	57723|Acidobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
TLS2_k127_2310065_1	1267535.KB906767_gene4699	2.02e-48	176.0	COG4447@1|root,COG4447@2|Bacteria,3Y2MX@57723|Acidobacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
TLS2_k127_2310065_2	1166948.JPZL01000004_gene51	1.837e-27	118.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23,Response_reg
TLS2_k127_2310065_0	640511.BC1002_6472	1.838e-256	834.0	COG0642@1|root,COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJI1@28216|Betaproteobacteria,1JZSA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS,PAS_10,Response_reg
TLS2_k127_2310065_3	1166948.JPZL01000004_gene50	2.709e-19	92.0	COG4585@1|root,COG5002@1|root,COG4585@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HWE_HK,HisKA_3,PAS_4
TLS2_k127_2323571_2	1121033.AUCF01000017_gene3779	1.54e-32	130.0	COG1620@1|root,COG1620@2|Bacteria,1MV13@1224|Proteobacteria,2TQY1@28211|Alphaproteobacteria,2JT22@204441|Rhodospirillales	204441|Rhodospirillales	C	L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
TLS2_k127_2323571_1	518766.Rmar_1735	1.601e-77	269.0	COG1082@1|root,COG1082@2|Bacteria,4NJ3Z@976|Bacteroidetes,1FJUS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_2323571_0	903818.KI912269_gene310	2.901e-159	522.0	COG1032@1|root,COG1032@2|Bacteria,3Y2NI@57723|Acidobacteria	57723|Acidobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
TLS2_k127_232454_1	234267.Acid_0334	2.414e-58	225.0	COG1305@1|root,COG1305@2|Bacteria,3Y5BT@57723|Acidobacteria	57723|Acidobacteria	E	Domain of unknown function (DUF3488)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,DUF4129,Transglut_core
TLS2_k127_232454_2	335543.Sfum_3276	9.72e-31	136.0	COG1721@1|root,COG1721@2|Bacteria,1N8IQ@1224|Proteobacteria,42S2K@68525|delta/epsilon subdivisions,2WNA2@28221|Deltaproteobacteria,2MRVJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_232454_0	204669.Acid345_3201	8.698e-112	370.0	COG0714@1|root,COG0714@2|Bacteria,3Y4G8@57723|Acidobacteria,2JKTE@204432|Acidobacteriia	204432|Acidobacteriia	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_2340441_0	649638.Trad_1499	1.15e-118	392.0	COG1620@1|root,COG1620@2|Bacteria,1WMUR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	COGs COG1620 L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
TLS2_k127_2340441_1	344747.PM8797T_05550	9.195e-118	389.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,2IZS3@203682|Planctomycetes	203682|Planctomycetes	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	-	-	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18
TLS2_k127_2340441_2	452637.Oter_0831	1.221e-38	146.0	COG2366@1|root,COG2366@2|Bacteria	2|Bacteria	D	antibiotic biosynthetic process	acyII	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS2_k127_2346728_1	880070.Cycma_1902	5.318e-33	148.0	28MHM@1|root,2ZAUH@2|Bacteria,4NKMG@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2346728_0	331869.BAL199_09188	4.276e-43	160.0	COG2267@1|root,COG2267@2|Bacteria,1RATF@1224|Proteobacteria,2TTCT@28211|Alphaproteobacteria,4BR40@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	ko:K18092	ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220	-	R05366	RC00752,RC00753	br01602,ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_2348172_0	682795.AciX8_3432	5.581e-192	627.0	COG4932@1|root,COG4932@2|Bacteria,3Y438@57723|Acidobacteria,2JM1R@204432|Acidobacteriia	204432|Acidobacteriia	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_2348172_2	682795.AciX8_2823	1.239e-39	156.0	COG1802@1|root,COG1802@2|Bacteria,3Y7UB@57723|Acidobacteria,2JMZ9@204432|Acidobacteriia	204432|Acidobacteriia	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_2348172_3	458817.Shal_1970	0.0004981	44.0	COG1943@1|root,COG1943@2|Bacteria,1MVUV@1224|Proteobacteria,1RNIV@1236|Gammaproteobacteria,2Q9MT@267890|Shewanellaceae	1236|Gammaproteobacteria	L	COG1943 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2348172_1	204669.Acid345_4194	7.391e-45	179.0	COG0457@1|root,COG3577@1|root,COG0457@2|Bacteria,COG3577@2|Bacteria,3Y5JY@57723|Acidobacteria,2JN39@204432|Acidobacteriia	204432|Acidobacteriia	S	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2355174_1	204669.Acid345_0153	3.661e-100	336.0	COG0439@1|root,COG0439@2|Bacteria,3Y3FH@57723|Acidobacteria,2JKRD@204432|Acidobacteriia	204432|Acidobacteriia	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TLS2_k127_2355174_2	204669.Acid345_0154	2.073e-11	72.0	COG4770@1|root,COG4770@2|Bacteria,3Y5QJ@57723|Acidobacteria,2JN6E@204432|Acidobacteriia	204432|Acidobacteriia	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
TLS2_k127_2355174_0	1379270.AUXF01000001_gene2296	2.575e-128	446.0	COG1196@1|root,COG1196@2|Bacteria,1ZU8V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2361791_0	378806.STAUR_3925	2.416e-207	656.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YWK2@29|Myxococcales	28221|Deltaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
TLS2_k127_2362248_0	1502851.FG93_03317	8.512e-127	420.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TVTA@28211|Alphaproteobacteria,3JUN2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	2.6.1.102,2.6.1.109	ko:K13010,ko:K19715	ko00520,map00520	-	R10460,R11395	RC00006,RC00160,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_2362248_1	861299.J421_4395	3.444e-50	183.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_2362248_3	644283.Micau_4909	5.8e-06	54.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,2GXAS@201174|Actinobacteria,4DDM1@85008|Micromonosporales	201174|Actinobacteria	K	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,HTH_31
TLS2_k127_2362248_2	880073.Calab_0527	3.068e-06	51.0	COG0454@1|root,COG1022@1|root,COG0456@2|Bacteria,COG1022@2|Bacteria	2|Bacteria	I	Amp-dependent synthetase and ligase	fadD	-	2.5.1.16,6.2.1.3	ko:K00797,ko:K01897	ko00061,ko00071,ko00270,ko00330,ko00410,ko00480,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00270,map00330,map00410,map00480,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00034,M00086,M00133	R01280,R01920,R02869,R08359	RC00004,RC00014,RC00021,RC00053	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS2_k127_2362337_0	768710.DesyoDRAFT_1953	5.095e-135	451.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260RG@186807|Peptococcaceae	186801|Clostridia	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
TLS2_k127_2362391_0	1267535.KB906767_gene758	6.545e-164	546.0	COG1530@1|root,COG1530@2|Bacteria,3Y40K@57723|Acidobacteria,2JHQU@204432|Acidobacteriia	204432|Acidobacteriia	J	PFAM RNA-binding protein AU-1 Ribonuclease E G	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
TLS2_k127_2362391_1	289376.THEYE_A2090	3.926e-76	264.0	COG1694@1|root,COG3956@2|Bacteria,3J0Q7@40117|Nitrospirae	40117|Nitrospirae	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	ko:K02499	-	-	-	-	ko00000,ko03036	-	-	-	MazG
TLS2_k127_2364975_3	1183438.GKIL_2517	6.13e-66	229.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TLS2_k127_2364975_1	1267535.KB906767_gene632	9.962e-114	372.0	COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria,2JIKD@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_2364975_2	234267.Acid_6478	6.271e-106	347.0	COG1136@1|root,COG1136@2|Bacteria,3Y2X0@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_2364975_0	234267.Acid_4168	5.893e-203	640.0	COG2204@1|root,COG2204@2|Bacteria,3Y33M@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_2364975_4	234267.Acid_4169	1.26e-56	205.0	COG5000@1|root,COG5000@2|Bacteria,3Y2TD@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
TLS2_k127_2380030_1	204669.Acid345_2357	1.28e-21	100.0	COG2980@1|root,COG2980@2|Bacteria,3Y4V4@57723|Acidobacteria,2JJKB@204432|Acidobacteriia	204432|Acidobacteriia	M	Lipopolysaccharide-assembly	-	-	-	-	-	-	-	-	-	-	-	-	LptE
TLS2_k127_2380030_3	1121091.AUMP01000002_gene1883	1.365e-11	75.0	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,4HBB4@91061|Bacilli	91061|Bacilli	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
TLS2_k127_2380030_2	857293.CAAU_2310	2.422e-18	88.0	COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,24QNX@186801|Clostridia,36KIE@31979|Clostridiaceae	186801|Clostridia	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
TLS2_k127_2380030_0	204669.Acid345_3538	2.712e-107	357.0	COG1702@1|root,COG1702@2|Bacteria,3Y3RM@57723|Acidobacteria,2JI4V@204432|Acidobacteriia	204432|Acidobacteriia	T	PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
TLS2_k127_2380030_4	29540.C481_05455	0.0004217	42.0	COG0010@1|root,arCOG01700@2157|Archaea,2XU8D@28890|Euryarchaeota,23U2W@183963|Halobacteria	183963|Halobacteria	E	Belongs to the arginase family	arg2	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS2_k127_2398143_0	1267535.KB906767_gene265	6.661e-147	481.0	COG0443@1|root,COG0443@2|Bacteria	2|Bacteria	O	unfolded protein binding	hscA	-	-	-	-	-	-	-	-	-	-	-	HSP70,RNase_Zc3h12a
TLS2_k127_2398143_1	1168034.FH5T_09240	6.109e-107	359.0	COG1262@1|root,COG3005@1|root,COG1262@2|Bacteria,COG3005@2|Bacteria,4NEUZ@976|Bacteroidetes,2FQ5J@200643|Bacteroidia	976|Bacteroidetes	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT,FGE-sulfatase
TLS2_k127_240182_2	1499967.BAYZ01000095_gene4057	5.063e-86	296.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlA	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
TLS2_k127_240182_1	1499967.BAYZ01000028_gene1264	1.66e-129	423.0	COG1181@1|root,COG1181@2|Bacteria,2NRF0@2323|unclassified Bacteria	2|Bacteria	M	ATP-grasp domain	ddlA	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
TLS2_k127_240182_0	1121861.KB899916_gene1707	1.165e-184	586.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,2TT31@28211|Alphaproteobacteria,2JPK9@204441|Rhodospirillales	204441|Rhodospirillales	E	lysine 2,3-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_2411859_2	1101192.KB910516_gene1913	2.71e-29	124.0	COG4803@1|root,COG4803@2|Bacteria,1QU69@1224|Proteobacteria,2TW1D@28211|Alphaproteobacteria,1JSPX@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	membrane protein of uknown function UCP014873	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2411859_0	518766.Rmar_1790	1.622e-150	489.0	COG1228@1|root,COG1228@2|Bacteria,4NEV0@976|Bacteroidetes	976|Bacteroidetes	Q	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_2411859_1	1267535.KB906767_gene3595	1.012e-43	172.0	COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria,2JJYF@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS2_k127_2419671_1	1210884.HG799466_gene12640	3.298e-42	168.0	COG1621@1|root,COG1621@2|Bacteria,2IY26@203682|Planctomycetes	203682|Planctomycetes	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2419671_2	1191523.MROS_1682	1.72e-32	131.0	COG2731@1|root,COG2731@2|Bacteria	2|Bacteria	G	single-species biofilm formation	tabA_2	-	-	-	-	-	-	-	-	-	-	-	DUF386
TLS2_k127_2419671_0	1449063.JMLS01000007_gene3403	6.245e-83	285.0	COG3408@1|root,COG3408@2|Bacteria,1U02P@1239|Firmicutes,4I9CQ@91061|Bacilli,271CA@186822|Paenibacillaceae	91061|Bacilli	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2432324_0	404589.Anae109_3510	1.903e-50	186.0	COG3214@1|root,COG3214@2|Bacteria,1R9AI@1224|Proteobacteria	1224|Proteobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS2_k127_2432324_1	1089545.KB913037_gene2797	4.032e-45	176.0	2DBYY@1|root,2ZBYF@2|Bacteria,2HMYF@201174|Actinobacteria,4E4XV@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2432324_2	1307761.L21SP2_0412	1.253e-21	103.0	COG0454@1|root,COG0456@2|Bacteria,2J7A2@203691|Spirochaetes	203691|Spirochaetes	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_2444721_0	1047013.AQSP01000120_gene937	4.613e-194	610.0	COG4030@1|root,COG4030@2|Bacteria	2|Bacteria	M	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
TLS2_k127_2444721_1	1191523.MROS_2231	3.603e-111	368.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
TLS2_k127_2459306_4	1304888.ATWF01000002_gene508	1.328e-19	92.0	COG2332@1|root,COG2332@2|Bacteria,2GFT9@200930|Deferribacteres	200930|Deferribacteres	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
TLS2_k127_2459306_0	926550.CLDAP_40030	1.048e-189	612.0	COG1138@1|root,COG1138@2|Bacteria,2G5SZ@200795|Chloroflexi	200795|Chloroflexi	O	PFAM Cytochrome C assembly protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
TLS2_k127_2459306_5	246194.CHY_1361	1.188e-14	81.0	COG3088@1|root,COG3088@2|Bacteria,1VNV1@1239|Firmicutes,254YU@186801|Clostridia	186801|Clostridia	P	subunit of a heme lyase	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
TLS2_k127_2459306_7	926550.CLDAP_40020	4.446e-05	49.0	2DRD8@1|root,33BA3@2|Bacteria,2G7EV@200795|Chloroflexi	200795|Chloroflexi	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
TLS2_k127_2459306_2	1125863.JAFN01000001_gene3012	5.215e-64	226.0	COG1131@1|root,COG1131@2|Bacteria,1RGM1@1224|Proteobacteria,43ADE@68525|delta/epsilon subdivisions,2X5TA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
TLS2_k127_2459306_3	552811.Dehly_0439	1.638e-44	170.0	COG2386@1|root,COG2386@2|Bacteria,2G6TN@200795|Chloroflexi	200795|Chloroflexi	O	PFAM cytochrome c-type biogenesis protein CcmB	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
TLS2_k127_2459306_1	871963.Desdi_1122	7.029e-74	256.0	COG0755@1|root,COG0755@2|Bacteria,1V4A6@1239|Firmicutes,24IWH@186801|Clostridia,264K0@186807|Peptococcaceae	186801|Clostridia	O	Cytochrome c assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
TLS2_k127_2459306_6	204669.Acid345_0705	5.427e-07	61.0	COG2304@1|root,COG2304@2|Bacteria,3Y2PC@57723|Acidobacteria,2JI8N@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_2471262_1	1125863.JAFN01000001_gene1797	1.207e-44	164.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2WQ6E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
TLS2_k127_2471262_2	1232410.KI421419_gene2480	2.206e-26	113.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WQ7I@28221|Deltaproteobacteria,43UXA@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Hsp20/alpha crystallin family	hspA-1	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS2_k127_2471262_0	768706.Desor_0968	1.109e-136	445.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,25ZZ7@186807|Peptococcaceae	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS2_k127_2471262_3	1121423.JONT01000010_gene1812	2.803e-12	71.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,261QI@186807|Peptococcaceae	186801|Clostridia	C	FeS cluster assembly scaffold protein NifU	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS2_k127_2491152_2	1121396.KB893065_gene1615	1.583e-43	167.0	2CHE3@1|root,31B2D@2|Bacteria,1RM3N@1224|Proteobacteria,42TDP@68525|delta/epsilon subdivisions,2WPWY@28221|Deltaproteobacteria,2MNMG@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2491152_1	880074.BARVI_03030	9.257e-89	317.0	COG1874@1|root,COG1874@2|Bacteria,4PNM8@976|Bacteroidetes,2G105@200643|Bacteroidia,22YWU@171551|Porphyromonadaceae	976|Bacteroidetes	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2491152_0	1122931.AUAE01000007_gene1342	1.341e-198	636.0	COG0457@1|root,COG0457@2|Bacteria,4NKMF@976|Bacteroidetes,2FXC5@200643|Bacteroidia,231HD@171551|Porphyromonadaceae	1122931.AUAE01000007_gene1342|-	S	Domain of unknown function (DUF5107)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2496450_1	1382359.JIAL01000001_gene2411	3.936e-111	366.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria,2JIG9@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_2496450_5	1125863.JAFN01000001_gene267	5.676e-36	145.0	COG0811@1|root,COG0811@2|Bacteria,1NBED@1224|Proteobacteria,42WAH@68525|delta/epsilon subdivisions,2X5KM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	MotA TolQ ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
TLS2_k127_2496450_9	1125863.JAFN01000001_gene268	5.068e-11	69.0	COG0848@1|root,COG0848@2|Bacteria,1NN40@1224|Proteobacteria,42XMQ@68525|delta/epsilon subdivisions	1224|Proteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS2_k127_2496450_7	1125863.JAFN01000001_gene268	2.886e-13	75.0	COG0848@1|root,COG0848@2|Bacteria,1NN40@1224|Proteobacteria,42XMQ@68525|delta/epsilon subdivisions	1224|Proteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS2_k127_2496450_8	130081.XP_005704959.1	8.588e-12	76.0	COG0457@1|root,KOG1124@2759|Eukaryota	2759|Eukaryota	O	cellular component assembly	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_6,TPR_8
TLS2_k127_2496450_0	1519464.HY22_09440	3.632e-169	544.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_2496450_4	313596.RB2501_00586	3.676e-54	202.0	COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,4NFWN@976|Bacteroidetes,1HWTQ@117743|Flavobacteriia	976|Bacteroidetes	O	redox protein regulator of disulfide bond formation	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4,OsmC
TLS2_k127_2496450_3	1123248.KB893326_gene1337	1.206e-77	269.0	COG1940@1|root,COG1940@2|Bacteria,4NJ71@976|Bacteroidetes,1IS5A@117747|Sphingobacteriia	976|Bacteroidetes	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_2496450_2	357808.RoseRS_1608	4.7e-94	319.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_2496450_6	234267.Acid_0793	1.203e-16	82.0	COG1595@1|root,COG1595@2|Bacteria,3Y4HK@57723|Acidobacteria	57723|Acidobacteria	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2502165_1	671143.DAMO_0822	1.653e-109	368.0	COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
TLS2_k127_2502165_0	1379698.RBG1_1C00001G0780	3.671e-148	477.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petB	-	-	ko:K00410,ko:K00412,ko:K02635,ko:K02637	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	-	-	ko00000,ko00001,ko00002,ko00194,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
TLS2_k127_2502165_2	1379698.RBG1_1C00001G0781	4.275e-56	199.0	COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria	2|Bacteria	C	Rieske [2Fe-2S] domain	petA	-	1.10.2.2,1.10.9.1	ko:K00411,ko:K02636,ko:K03886	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske,UCR_Fe-S_N
TLS2_k127_2502165_3	768066.HELO_1620	0.0006046	44.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XIXB@135619|Oceanospirillales	135619|Oceanospirillales	T	With GlrK is part of a two-component signal transduction system regulating glmY	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_2504375_0	404380.Gbem_2236	4.375e-117	394.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WK23@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
TLS2_k127_2504375_1	525904.Tter_2007	2.408e-65	229.0	2CB42@1|root,2Z7Y3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2507627_5	279010.BL01611	2.042e-25	110.0	COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,4HD4A@91061|Bacilli,1ZDWU@1386|Bacillus	91061|Bacilli	T	COG0642 Signal transduction histidine kinase	kinC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K07698	ko02020,map02020	M00485	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_9
TLS2_k127_2507627_2	247490.KSU1_C0605	4.289e-61	220.0	COG0300@1|root,COG0300@2|Bacteria,2IZMH@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
TLS2_k127_2507627_9	1120797.KB908268_gene3449	3.389e-12	79.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,233IU@1762|Mycobacteriaceae	201174|Actinobacteria	K	Member of the two-component regulatory system MprB MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region	mprA	GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009268,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010446,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0023052,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0035556,GO:0043254,GO:0044087,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090034,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K07669,ko:K07672	ko02020,map02020	M00460,M00463	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_2507627_6	933262.AXAM01000005_gene2533	4.109e-21	107.0	COG1639@1|root,COG1639@2|Bacteria,1R8H3@1224|Proteobacteria,42PER@68525|delta/epsilon subdivisions,2X29A@28221|Deltaproteobacteria,2MNF5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TLS2_k127_2507627_4	497964.CfE428DRAFT_5470	2.017e-48	190.0	COG2204@1|root,COG2204@2|Bacteria,46VVS@74201|Verrucomicrobia	74201|Verrucomicrobia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_2507627_3	247490.KSU1_B0680	6.176e-58	217.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	fadL	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
TLS2_k127_2507627_8	118161.KB235922_gene1480	6.691e-15	87.0	COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,3VMER@52604|Pleurocapsales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
TLS2_k127_2507627_7	313624.NSP_39340	3.72e-19	100.0	COG4251@1|root,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,1HM6E@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	aphA	-	2.7.13.3	ko:K11354	ko02020,map02020	M00510	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,HATPase_c,HisKA,PAS_2,PHY
TLS2_k127_2507627_0	1487953.JMKF01000028_gene1253	1.855e-147	492.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H9JN@1150|Oscillatoriales	1117|Cyanobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,FHA,GAF,GGDEF,PAS_3,PAS_9,Response_reg
TLS2_k127_2507627_1	234267.Acid_3288	5.64e-95	312.0	COG3865@1|root,COG3865@2|Bacteria,3Y4UB@57723|Acidobacteria	57723|Acidobacteria	H	3-demethylubiquinone-9 3-methyltransferase	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	3-dmu-9_3-mt
TLS2_k127_2507627_10	865861.AZSU01000004_gene965	9.705e-06	49.0	2BBRW@1|root,325A1@2|Bacteria,1URDA@1239|Firmicutes,24WPQ@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2507627_11	935863.AWZR01000003_gene2769	2.557e-05	46.0	COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,1RPDF@1236|Gammaproteobacteria,1X4EU@135614|Xanthomonadales	135614|Xanthomonadales	G	Aldolase	eda	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
TLS2_k127_250786_6	504472.Slin_1881	2.166e-29	124.0	COG4251@1|root,COG4251@2|Bacteria,4NK2S@976|Bacteroidetes,47MAR@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
TLS2_k127_250786_5	765911.Thivi_0288	6.98e-35	136.0	COG4251@1|root,COG4251@2|Bacteria,1N44A@1224|Proteobacteria,1SECK@1236|Gammaproteobacteria,1X14T@135613|Chromatiales	135613|Chromatiales	T	KaiB	-	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	KaiB
TLS2_k127_250786_4	555779.Dthio_PD0975	9.648e-42	157.0	COG4251@1|root,COG4251@2|Bacteria,1N1KJ@1224|Proteobacteria,42W7E@68525|delta/epsilon subdivisions,2WSCW@28221|Deltaproteobacteria,2MDGI@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	KaiB	-	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	KaiB
TLS2_k127_250786_0	316067.Geob_3570	2.347e-220	700.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,42P4F@68525|delta/epsilon subdivisions,2WJVT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Pfam:KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
TLS2_k127_250786_1	1410620.SHLA_36c000140	2.146e-142	456.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_250786_3	234267.Acid_1799	3.234e-101	336.0	COG0384@1|root,COG0384@2|Bacteria,3Y7JN@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Phenazine biosynthesis PhzC PhzF protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
TLS2_k127_250786_7	1408224.SAMCCGM7_c6064	1.219e-05	52.0	COG2010@1|root,COG2993@1|root,COG2010@2|Bacteria,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2TRGW@28211|Alphaproteobacteria,4BASB@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	cytochrome C oxidase mono-heme subunit FixO	-	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixO
TLS2_k127_250786_2	1173023.KE650771_gene1916	3.366e-132	431.0	COG4221@1|root,COG4221@2|Bacteria,1GQ39@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_2519361_0	1123242.JH636436_gene627	9.114e-199	632.0	COG1621@1|root,COG1621@2|Bacteria,2J209@203682|Planctomycetes	203682|Planctomycetes	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2519361_1	1122605.KB893637_gene3261	7.404e-162	518.0	COG4948@1|root,COG4948@2|Bacteria,4NIIJ@976|Bacteroidetes,1IQE9@117747|Sphingobacteriia	976|Bacteroidetes	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	5.5.1.27	ko:K18983	ko00053,map00053	-	R10847	RC03287	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_2519361_2	1122605.KB893637_gene3262	2.885e-109	364.0	COG0111@1|root,COG0111@2|Bacteria,4NE9J@976|Bacteroidetes	976|Bacteroidetes	EH	PFAM D-isomer specific 2-hydroxyacid dehydrogenase	ghrA	-	1.1.1.79,1.1.1.81	ko:K12972	ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R01388,R01392,R02527	RC00031,RC00042,RC00670	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh_C
TLS2_k127_2523618_2	340099.Teth39_0903	8.007e-46	172.0	COG2185@1|root,COG2185@2|Bacteria,1V3QN@1239|Firmicutes,24HAR@186801|Clostridia,42G8Z@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM cobalamin B12-binding domain protein	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
TLS2_k127_2523618_1	68260.JOAY01000002_gene5233	6.209e-71	253.0	COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria	201174|Actinobacteria	E	LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS2_k127_2523618_0	273068.TTE1217	6.76e-239	751.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,42FIA@68295|Thermoanaerobacterales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS2_k127_2523618_3	349520.PPE_02714	7.554e-27	119.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,4HB60@91061|Bacilli,26QTA@186822|Paenibacillaceae	91061|Bacilli	K	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
TLS2_k127_2533215_0	1499967.BAYZ01000190_gene3842	3.936e-94	316.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	3.4.13.22	ko:K08641,ko:K11206	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	CN_hydrolase,Peptidase_M15
TLS2_k127_2533215_1	472759.Nhal_3295	2.063e-26	126.0	COG1680@1|root,COG1680@2|Bacteria,1NPBV@1224|Proteobacteria,1SQWZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Domain of unknown function (DUF4185)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185
TLS2_k127_2535366_4	518766.Rmar_0721	8.414e-09	68.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2535366_1	234267.Acid_5283	3.037e-109	365.0	COG0436@1|root,COG0436@2|Bacteria,3Y2VQ@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS2_k127_2535366_5	1121938.AUDY01000007_gene2501	2.321e-06	50.0	2DR03@1|root,339MB@2|Bacteria,1VK6Y@1239|Firmicutes,4HR34@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2535366_3	1267533.KB906740_gene277	1.929e-19	100.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797,ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
TLS2_k127_2535366_2	234267.Acid_1209	5.607e-57	205.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_2535366_0	234267.Acid_0024	1.363e-194	641.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_2547322_2	1340493.JNIF01000004_gene290	8.874e-12	66.0	COG2010@1|root,COG4654@1|root,COG2010@2|Bacteria,COG4654@2|Bacteria	2|Bacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PSCyt1,PSCyt2,PSD1
TLS2_k127_2547322_0	1340493.JNIF01000004_gene289	1.625e-205	649.0	COG3119@1|root,COG3119@2|Bacteria,3Y683@57723|Acidobacteria	57723|Acidobacteria	P	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_2547322_1	278963.ATWD01000003_gene34	7.607e-105	360.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_2547729_2	1340493.JNIF01000003_gene4792	2.724e-51	189.0	COG1721@1|root,COG1721@2|Bacteria,3Y5XW@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_2547729_1	1379270.AUXF01000001_gene2299	3.025e-127	415.0	COG0714@1|root,COG0714@2|Bacteria,1ZUSV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_2547729_0	234267.Acid_6436	1.394e-139	468.0	COG0457@1|root,COG0457@2|Bacteria,3Y6C4@57723|Acidobacteria	57723|Acidobacteria	E	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8
TLS2_k127_2548592_3	383381.EH30_08800	3.709e-06	58.0	COG1266@1|root,COG1266@2|Bacteria,1MYYZ@1224|Proteobacteria,2UM8W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_2548592_0	215803.DB30_3742	2.039e-15	91.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,PKD,Peptidase_S8
TLS2_k127_2548592_2	1123261.AXDW01000011_gene504	1.01e-10	75.0	COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,1RMJ7@1236|Gammaproteobacteria,1X9HN@135614|Xanthomonadales	135614|Xanthomonadales	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,OmpA
TLS2_k127_2548592_1	278963.ATWD01000001_gene1501	1.393e-13	74.0	COG3292@1|root,COG4447@1|root,COG3292@2|Bacteria,COG4447@2|Bacteria,3Y3Y6@57723|Acidobacteria,2JI5Y@204432|Acidobacteriia	204432|Acidobacteriia	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
TLS2_k127_2551426_0	292459.STH1757	2.844e-242	771.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
TLS2_k127_2551426_2	1499967.BAYZ01000084_gene3996	8.945e-33	136.0	COG1214@1|root,COG1214@2|Bacteria,2NPK8@2323|unclassified Bacteria	2|Bacteria	O	Glycoprotease family	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TLS2_k127_2551426_3	1403948.Q618_VCMC00003G0069	4.68e-17	89.0	COG0454@1|root,COG0456@2|Bacteria,2IM9R@201174|Actinobacteria,4D5ND@85005|Actinomycetales	201174|Actinobacteria	K	Ribosomal-protein-alanine acetyltransferase	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TLS2_k127_2551426_1	1379270.AUXF01000004_gene2931	1.355e-37	147.0	COG2866@1|root,COG2866@2|Bacteria,1ZUNB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS2_k127_2561469_1	1232410.KI421418_gene2260	1.724e-37	144.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,42NYD@68525|delta/epsilon subdivisions,2WKHT@28221|Deltaproteobacteria,43S9U@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Predicted permease YjgP/YjgQ family	lptF	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TLS2_k127_2561469_0	1232410.KI421418_gene2259	2.045e-130	432.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,42N5X@68525|delta/epsilon subdivisions,2WJ3H@28221|Deltaproteobacteria,43RYS@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Predicted permease YjgP/YjgQ family	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TLS2_k127_256766_0	1121335.Clst_1023	2.232e-143	475.0	COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,3WI3M@541000|Ruminococcaceae	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_256766_2	330214.NIDE3895	8.183e-31	128.0	COG1764@1|root,COG1764@2|Bacteria	2|Bacteria	O	response to oxidative stress	ymaD	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
TLS2_k127_256766_1	639282.DEFDS_1074	1.21e-66	231.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,2GETU@200930|Deferribacteres	200930|Deferribacteres	C	Malic enzyme, NAD binding domain	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
TLS2_k127_2574371_1	631362.Thi970DRAFT_00278	3.951e-07	59.0	COG1396@1|root,COG1396@2|Bacteria,1NHKX@1224|Proteobacteria	1224|Proteobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS2_k127_2574371_2	1415779.JOMH01000001_gene451	4.436e-06	49.0	COG5573@1|root,COG5573@2|Bacteria,1RKIK@1224|Proteobacteria,1SBYM@1236|Gammaproteobacteria,1X8SB@135614|Xanthomonadales	135614|Xanthomonadales	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_2574371_0	234267.Acid_5743	5.16e-84	283.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,3Y6PH@57723|Acidobacteria	57723|Acidobacteria	S	Putative glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like,VWA
TLS2_k127_2586158_0	1123276.KB893266_gene4471	1.557e-160	515.0	COG3458@1|root,COG3458@2|Bacteria,4NGH5@976|Bacteroidetes,47MHG@768503|Cytophagia	976|Bacteroidetes	Q	PFAM Acetyl xylan esterase	axe7A_2	-	-	-	-	-	-	-	-	-	-	-	AXE1
TLS2_k127_2586158_3	1232437.KL661969_gene4964	2.282e-78	269.0	COG3910@1|root,COG3910@2|Bacteria,1MZSY@1224|Proteobacteria,42R25@68525|delta/epsilon subdivisions,2WN2C@28221|Deltaproteobacteria,2MJIF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21,AAA_23
TLS2_k127_2586158_4	1121920.AUAU01000006_gene301	5.293e-51	186.0	2BYAB@1|root,32R2Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2586158_6	485913.Krac_5413	9.689e-07	59.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
TLS2_k127_2586158_1	935567.JAES01000027_gene1298	2.995e-83	288.0	COG1028@1|root,COG1028@2|Bacteria,1MW46@1224|Proteobacteria,1S08S@1236|Gammaproteobacteria,1X5TM@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
TLS2_k127_2586158_5	1125701.HMPREF1221_01616	1.997e-48	192.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2586158_2	344747.PM8797T_18384	2.04e-82	290.0	COG0673@1|root,COG0673@2|Bacteria,2IWRC@203682|Planctomycetes	203682|Planctomycetes	S	COGs COG0673 dehydrogenase and related protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_2588670_1	1267535.KB906767_gene3575	1.4e-116	385.0	COG1915@1|root,COG1915@2|Bacteria,3Y7FB@57723|Acidobacteria	57723|Acidobacteria	S	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2588670_2	1123242.JH636434_gene4775	1.605e-69	249.0	COG2870@1|root,COG2870@2|Bacteria,2IZ16@203682|Planctomycetes	203682|Planctomycetes	M	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS2_k127_2588670_0	861299.J421_0949	1.868e-153	515.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_0949|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2592473_2	1211813.CAPH01000013_gene540	6.633e-39	166.0	COG3533@1|root,COG3533@2|Bacteria,4NFW3@976|Bacteroidetes,2FRKH@200643|Bacteroidia	976|Bacteroidetes	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
TLS2_k127_2592473_1	1210908.HSB1_01110	8.013e-53	195.0	COG0819@1|root,arCOG01128@2157|Archaea,2XTG7@28890|Euryarchaeota,23STS@183963|Halobacteria	183963|Halobacteria	K	transcription activator	tenA	-	3.5.99.2	ko:K03707	ko00730,ko01100,map00730,map01100	-	R02133,R09993	RC00224,RC00652,RC02832	ko00000,ko00001,ko01000,ko03000	-	-	-	TENA_THI-4
TLS2_k127_2592473_0	1121406.JAEX01000002_gene1142	1.682e-88	298.0	COG0500@1|root,COG2226@2|Bacteria,1RDQI@1224|Proteobacteria,42SIB@68525|delta/epsilon subdivisions,2WPCP@28221|Deltaproteobacteria,2ME8A@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_259741_2	1118054.CAGW01000014_gene295	2.927e-13	70.0	COG0451@1|root,COG0451@2|Bacteria,1TPHV@1239|Firmicutes,4HCJR@91061|Bacilli,26SNR@186822|Paenibacillaceae	91061|Bacilli	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_259741_0	344747.PM8797T_09494	1.708e-183	592.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	Z012_09690	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_259741_1	1121957.ATVL01000007_gene2107	1.626e-26	110.0	COG0702@1|root,COG0702@2|Bacteria,4NEJF@976|Bacteroidetes,47MFP@768503|Cytophagia	976|Bacteroidetes	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,Epimerase,NAD_binding_10
TLS2_k127_2606848_1	443143.GM18_4037	1.222e-23	100.0	COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria,43TPS@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
TLS2_k127_2606848_0	443144.GM21_0436	0.0	1698.0	COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,1QW22@1224|Proteobacteria	1224|Proteobacteria	M	Ompa motb domain protein	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS2_k127_2611417_0	1267535.KB906767_gene1670	3.27e-47	182.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_2611417_1	1267535.KB906767_gene1669	9.013e-32	135.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_2611417_3	1288963.ADIS_1776	3.107e-08	66.0	COG4409@1|root,COG4409@2|Bacteria,4NKEW@976|Bacteroidetes,47U77@768503|Cytophagia	976|Bacteroidetes	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_2611417_2	344747.PM8797T_22933	7.293e-28	126.0	COG1621@1|root,COG1621@2|Bacteria,2J36G@203682|Planctomycetes	203682|Planctomycetes	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2623968_2	671143.DAMO_1616	4.442e-118	392.0	COG1034@1|root,COG1034@2|Bacteria	2|Bacteria	C	ATP synthesis coupled electron transport	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
TLS2_k127_2623968_0	936136.ARRT01000006_gene5766	6.019e-151	489.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2U2JT@28211|Alphaproteobacteria,4BB5D@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF2	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
TLS2_k127_2623968_6	1191523.MROS_0156	5.326e-38	150.0	COG1905@1|root,COG1905@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	nuoE	-	1.6.5.3	ko:K00334,ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
TLS2_k127_2623968_1	1144275.COCOR_05310	1.606e-140	460.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2YU4Q@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
TLS2_k127_2623968_5	1131269.AQVV01000018_gene1932	1.221e-58	207.0	COG0852@1|root,COG0852@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3353	Complex1_30kDa
TLS2_k127_2623968_4	404589.Anae109_1291	1.075e-66	234.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2WN9U@28221|Deltaproteobacteria,2YUX6@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3354	Oxidored_q6
TLS2_k127_2623968_7	926569.ANT_08290	1.536e-22	102.0	COG0838@1|root,COG0838@2|Bacteria,2G78Y@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TLS2_k127_2623968_3	1267533.KB906740_gene150	5.812e-102	341.0	COG0320@1|root,COG0320@2|Bacteria,3Y3D4@57723|Acidobacteria,2JI3W@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
TLS2_k127_2623968_8	1190606.AJYG01000178_gene3470	5.035e-09	63.0	COG2128@1|root,COG2128@2|Bacteria,1RBG0@1224|Proteobacteria,1S26Z@1236|Gammaproteobacteria,1XUKD@135623|Vibrionales	135623|Vibrionales	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_2629162_2	1403819.BATR01000092_gene2658	3.519e-94	313.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_2629162_0	234267.Acid_4914	7.554e-135	443.0	COG0531@1|root,COG0531@2|Bacteria,3Y3Z8@57723|Acidobacteria	2|Bacteria	E	amino acid	frlA	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006040,GO:0006082,GO:0006520,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0009056,GO:0009063,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0016054,GO:0019752,GO:0022804,GO:0022857,GO:0030389,GO:0030392,GO:0030393,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046348,GO:0046395,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098656,GO:1901135,GO:1901136,GO:1901281,GO:1901564,GO:1901565,GO:1901575,GO:1902475,GO:1903825,GO:1905039	-	ko:K03294,ko:K19540	-	-	-	-	ko00000,ko02000	2.A.3.2,2.A.3.8.17	-	iAF1260.b3370,iB21_1397.B21_03173,iBWG_1329.BWG_3062,iEC042_1314.EC042_3632,iEC55989_1330.EC55989_3776,iECBD_1354.ECBD_0378,iECB_1328.ECB_03221,iECDH10B_1368.ECDH10B_3546,iECDH1ME8569_1439.ECDH1ME8569_3250,iECD_1391.ECD_03221,iECIAI1_1343.ECIAI1_3509,iECO111_1330.ECO111_4180,iECO26_1355.ECO26_4459,iETEC_1333.ETEC_3621,iEcDH1_1363.EcDH1_0342,iJO1366.b3370,iSSON_1240.SSON_3502,iUMNK88_1353.UMNK88_4136,iY75_1357.Y75_RS20365	AA_permease_2
TLS2_k127_2629162_1	1123278.KB893616_gene3402	4.355e-119	400.0	COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,47T8D@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_2629162_3	641524.ADICYQ_3837	1.299e-27	128.0	28MHM@1|root,2ZAUH@2|Bacteria,4NKMG@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2648833_1	1173025.GEI7407_0339	1.269e-15	85.0	COG0438@1|root,COG0457@1|root,COG0859@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4915,Glyco_transf_9,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
TLS2_k127_2648833_0	234267.Acid_3370	8.309e-20	104.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	yabS	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA,VWA_2
TLS2_k127_2655714_1	1382359.JIAL01000001_gene1041	2.07e-45	172.0	2AZDP@1|root,31RMA@2|Bacteria,3Y4JB@57723|Acidobacteria,2JJ76@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF4230)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4230
TLS2_k127_2655714_0	861299.J421_1078	3.431e-117	387.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	ramA	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS2_k127_2665621_0	383372.Rcas_0372	1.132e-320	998.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi,37711@32061|Chloroflexia	32061|Chloroflexia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
TLS2_k127_2665621_1	502025.Hoch_2991	1.215e-98	330.0	COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,42UN5@68525|delta/epsilon subdivisions,2WQU9@28221|Deltaproteobacteria,2YXHW@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
TLS2_k127_267001_1	926569.ANT_13410	1.171e-30	125.0	COG0477@1|root,COG2814@2|Bacteria,2GBP2@200795|Chloroflexi	200795|Chloroflexi	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_267001_4	1198114.AciX9_1611	0.0005153	50.0	COG3170@1|root,COG3170@2|Bacteria,3Y4RX@57723|Acidobacteria,2JJBK@204432|Acidobacteriia	204432|Acidobacteriia	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_267001_3	292459.STH718	3.461e-10	73.0	COG1404@1|root,COG3291@1|root,COG4412@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG4412@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia	186801|Clostridia	O	Belongs to the peptidase S8 family	-	-	-	ko:K13276,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,Cu_amine_oxidN1,Inhibitor_I9,PPC,Peptidase_S8
TLS2_k127_267001_2	344747.PM8797T_15596	1.491e-30	124.0	2BZBR@1|root,32YH6@2|Bacteria,2J41E@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_267001_0	1499967.BAYZ01000118_gene3300	3.07e-61	226.0	COG1454@1|root,COG1454@2|Bacteria,2NQ5W@2323|unclassified Bacteria	2|Bacteria	C	Iron-containing alcohol dehydrogenase	CT0951	-	1.1.1.1,4.3.3.7	ko:K00001,ko:K01714,ko:K13954	ko00010,ko00071,ko00261,ko00300,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,ko01230,map00010,map00071,map00261,map00300,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220,map01230	M00016,M00525,M00526,M00527	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10147	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	Fe-ADH
TLS2_k127_2673630_1	1121403.AUCV01000053_gene2639	1.054e-112	380.0	COG4656@1|root,COG4656@2|Bacteria,1PJE1@1224|Proteobacteria,42P69@68525|delta/epsilon subdivisions,2WIM9@28221|Deltaproteobacteria,2MI2H@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,Fer4_17,RnfC_N,SLBB
TLS2_k127_2673630_3	493475.GARC_5324	7.274e-44	168.0	COG4577@1|root,COG4577@2|Bacteria,1R55P@1224|Proteobacteria,1RQTK@1236|Gammaproteobacteria,46AAQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	CQ	BMC	pduT	-	-	-	-	-	-	-	-	-	-	-	BMC
TLS2_k127_2673630_2	1121481.AUAS01000001_gene4367	5.185e-89	303.0	COG1082@1|root,COG1082@2|Bacteria,4NJF5@976|Bacteroidetes,47MRZ@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_2673630_0	1267535.KB906767_gene4986	2.143e-144	472.0	COG2382@1|root,COG2382@2|Bacteria,3Y98J@57723|Acidobacteria,2JP52@204432|Acidobacteriia	204432|Acidobacteriia	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	CBM_48,Esterase
TLS2_k127_2673630_4	1121481.AUAS01000008_gene2948	4.737e-26	116.0	COG1983@1|root,COG1983@2|Bacteria,4NR1R@976|Bacteroidetes,47QQE@768503|Cytophagia	976|Bacteroidetes	KT	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
TLS2_k127_2679873_2	485913.Krac_11786	5.77e-84	286.0	COG0249@1|root,COG0249@2|Bacteria,2G8CJ@200795|Chloroflexi	200795|Chloroflexi	L	PFAM DNA mismatch repair protein MutS domain protein	-	-	-	-	-	-	-	-	-	-	-	-	MutS_V
TLS2_k127_2679873_3	886293.Sinac_6000	1.64e-80	280.0	COG0388@1|root,COG0388@2|Bacteria,2IXKW@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
TLS2_k127_2679873_1	926550.CLDAP_06290	2.571e-129	420.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	ytaP	-	-	-	-	-	-	-	-	-	-	-	AXE1,Abhydrolase_7,DLH,Peptidase_S15,Peptidase_S9
TLS2_k127_2679873_4	335543.Sfum_3455	3.221e-60	223.0	COG1624@1|root,COG1624@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria,2MRQC@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	-	-	-	-	-	-	-	-	-	-	DisA_N,YbbR
TLS2_k127_2679873_0	240015.ACP_1615	5.738e-143	468.0	COG0008@1|root,COG0008@2|Bacteria,3Y465@57723|Acidobacteria,2JHZW@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS2_k127_2679873_5	234267.Acid_1035	2.383e-52	191.0	COG0463@1|root,COG0463@2|Bacteria,3Y982@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_26806_0	335543.Sfum_1748	4.487e-46	180.0	COG0593@1|root,COG1943@1|root,COG0593@2|Bacteria,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,42PP3@68525|delta/epsilon subdivisions,2X227@28221|Deltaproteobacteria,2MQQ2@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TLS2_k127_2686837_2	1121904.ARBP01000013_gene377	7.438e-69	241.0	COG1082@1|root,COG1082@2|Bacteria,4NPBS@976|Bacteroidetes,47Q6G@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_2686837_1	667014.Thein_2200	6.599e-82	284.0	COG0603@1|root,COG0603@2|Bacteria,2GHPZ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
TLS2_k127_2686837_0	1340493.JNIF01000003_gene2252	4.039e-140	457.0	COG2942@1|root,COG2942@2|Bacteria	2|Bacteria	G	2-epimerase	-	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
TLS2_k127_2686837_3	760568.Desku_2757	1.273e-44	167.0	COG0778@1|root,COG0778@2|Bacteria,1UB8S@1239|Firmicutes,249SD@186801|Clostridia,26212@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
TLS2_k127_2686837_4	436114.SYO3AOP1_0336	4.539e-07	61.0	COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,2G407@200783|Aquificae	200783|Aquificae	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
TLS2_k127_2692657_4	1121866.AUGK01000002_gene1457	2.811e-10	73.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4CUKV@84998|Coriobacteriia	84998|Coriobacteriia	KLT	Kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_2692657_3	314278.NB231_03465	4.22e-18	98.0	COG2815@1|root,COG2815@2|Bacteria	2|Bacteria	G	serine threonine protein kinase	-	-	2.7.11.1,3.4.16.4	ko:K03587,ko:K08884,ko:K12132	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01001,ko01011,ko03036	-	-	-	PASTA,Transpeptidase
TLS2_k127_2692657_2	246197.MXAN_6362	3.392e-20	104.0	2DR7M@1|root,33AJF@2|Bacteria,1N7KM@1224|Proteobacteria,42X8E@68525|delta/epsilon subdivisions,2WTFZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2692657_1	378806.STAUR_1428	1.071e-54	197.0	COG4385@1|root,COG4385@2|Bacteria,1N0CW@1224|Proteobacteria,42UPU@68525|delta/epsilon subdivisions,2WR0W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Phage tail protein (Tail_P2_I)	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
TLS2_k127_2692657_0	1121405.dsmv_1282	3.266e-55	199.0	COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,42QGQ@68525|delta/epsilon subdivisions,2WIVM@28221|Deltaproteobacteria,2MMI8@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
TLS2_k127_2697600_4	945713.IALB_2157	4.625e-12	66.0	COG1297@1|root,COG1297@2|Bacteria	2|Bacteria	S	iron-nicotianamine transmembrane transporter activity	oliA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085	-	-	-	-	-	-	-	-	-	-	OPT
TLS2_k127_2697600_3	1047013.AQSP01000111_gene1657	2.282e-17	87.0	2E6A2@1|root,3110F@2|Bacteria,2NS25@2323|unclassified Bacteria	2|Bacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
TLS2_k127_2697600_0	1121920.AUAU01000007_gene506	1.585e-188	597.0	COG0477@1|root,COG2814@2|Bacteria,3Y6YQ@57723|Acidobacteria	57723|Acidobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_2697600_1	234267.Acid_7881	9.451e-47	181.0	COG0812@1|root,COG0812@2|Bacteria,3Y3AT@57723|Acidobacteria	57723|Acidobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
TLS2_k127_2697600_2	1122619.KB892368_gene2404	3.791e-19	90.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,3T1BM@506|Alcaligenaceae	28216|Betaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TLS2_k127_2706831_1	404589.Anae109_3171	2.513e-27	116.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,43A75@68525|delta/epsilon subdivisions,2X9W3@28221|Deltaproteobacteria,2Z1PF@29|Myxococcales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
TLS2_k127_2706831_0	1121930.AQXG01000008_gene220	9.125e-48	189.0	COG1680@1|root,COG1680@2|Bacteria,4NEVS@976|Bacteroidetes	976|Bacteroidetes	V	COG1680 Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_2711149_4	1408473.JHXO01000011_gene2970	2.235e-71	252.0	COG0524@1|root,COG0524@2|Bacteria,4NGFK@976|Bacteroidetes,2FN72@200643|Bacteroidia	976|Bacteroidetes	G	Kinase, PfkB family	ydjH_1	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS2_k127_2711149_0	1382359.JIAL01000001_gene1007	4.95e-248	775.0	COG1069@1|root,COG1069@2|Bacteria,3Y3B6@57723|Acidobacteria,2JI84@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM Carbohydrate kinase	-	-	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100	-	R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
TLS2_k127_2711149_1	1267535.KB906767_gene2163	3.73e-230	720.0	COG2407@1|root,COG2407@2|Bacteria,3Y2FH@57723|Acidobacteria,2JI15@204432|Acidobacteriia	204432|Acidobacteriia	G	L-fucose isomerase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Fucose_iso_C
TLS2_k127_2711149_7	1121090.KB894689_gene351	7.027e-29	128.0	COG0346@1|root,COG0346@2|Bacteria,1V5GM@1239|Firmicutes,4HH66@91061|Bacilli,1ZD3V@1386|Bacillus	91061|Bacilli	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
TLS2_k127_2711149_5	755731.Clo1100_0586	4.07e-45	179.0	COG0251@1|root,COG0251@2|Bacteria,1W633@1239|Firmicutes,24VZE@186801|Clostridia	186801|Clostridia	J	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2711149_2	861299.J421_4032	2.322e-130	456.0	COG0457@1|root,COG0457@2|Bacteria	861299.J421_4032|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2711149_8	357808.RoseRS_0813	1.267e-15	84.0	COG3453@1|root,COG3453@2|Bacteria,2GB3Y@200795|Chloroflexi,3778V@32061|Chloroflexia	32061|Chloroflexia	S	Putative phosphatase (DUF442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF442
TLS2_k127_2711149_3	357808.RoseRS_1484	6.477e-120	393.0	COG0604@1|root,COG0604@2|Bacteria,2G6KH@200795|Chloroflexi,3763V@32061|Chloroflexia	32061|Chloroflexia	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_2711149_6	1185876.BN8_03007	7.326e-36	148.0	COG0726@1|root,COG0726@2|Bacteria,4NKYS@976|Bacteroidetes,47NF6@768503|Cytophagia	976|Bacteroidetes	G	PFAM Polysaccharide deacetylase	pgdA	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_2711149_9	1304888.ATWF01000001_gene1123	5.495e-13	71.0	COG2331@1|root,COG2331@2|Bacteria,2GG63@200930|Deferribacteres	200930|Deferribacteres	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TLS2_k127_2718937_1	485913.Krac_11822	6.234e-87	297.0	COG0155@1|root,COG0155@2|Bacteria,2G7ZA@200795|Chloroflexi	200795|Chloroflexi	C	Nitrite and sulphite reductase 4Fe-4S domain	-	-	1.8.7.1	ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
TLS2_k127_2718937_3	635013.TherJR_1133	1.183e-33	138.0	COG1648@1|root,COG1648@2|Bacteria,1VA2E@1239|Firmicutes,24N6M@186801|Clostridia,2625C@186807|Peptococcaceae	186801|Clostridia	H	TIGRFAM siroheme synthase	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M
TLS2_k127_2718937_2	491915.Aflv_0312	1.987e-74	262.0	COG0007@1|root,COG0007@2|Bacteria,1TQNH@1239|Firmicutes,4HBB7@91061|Bacilli,21W4U@150247|Anoxybacillus	91061|Bacilli	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	cobA	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.107	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15610	TP_methylase
TLS2_k127_2718937_0	368407.Memar_0875	0.0	1007.0	COG0753@1|root,arCOG03310@2157|Archaea,2XTIP@28890|Euryarchaeota,2N957@224756|Methanomicrobia	224756|Methanomicrobia	P	Catalase	-	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel,DJ-1_PfpI
TLS2_k127_2719947_0	335543.Sfum_0715	6.045e-103	343.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MR70@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS2_k127_2719947_2	349741.Amuc_1499	4.446e-11	73.0	COG3026@1|root,COG3026@2|Bacteria,46W95@74201|Verrucomicrobia,2IUUR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
TLS2_k127_2719947_1	278957.ABEA03000130_gene1706	3.299e-62	219.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	sigE1	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_2720109_2	749222.Nitsa_1318	1.44e-17	87.0	2EE7S@1|root,3382A@2|Bacteria,1NFK6@1224|Proteobacteria,42XB1@68525|delta/epsilon subdivisions,2YQX5@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2720109_1	278963.ATWD01000002_gene808	3.21e-33	141.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria,2JIRN@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
TLS2_k127_2720109_0	1267535.KB906767_gene1046	3.262e-34	139.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,OmpA,PD40
TLS2_k127_2723685_0	641524.ADICYQ_0052	2.881e-192	609.0	COG3119@1|root,COG3119@2|Bacteria,4NEQ5@976|Bacteroidetes,47N97@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_2723685_1	1169161.KB897733_gene525	3.23e-124	409.0	COG4946@1|root,COG4946@2|Bacteria,2IGV1@201174|Actinobacteria	201174|Actinobacteria	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2725697_0	1340493.JNIF01000003_gene1814	5.381e-93	340.0	COG3485@1|root,COG3485@2|Bacteria,3Y3FU@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_2739219_2	234267.Acid_5753	2.306e-38	151.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_2739219_1	1267535.KB906767_gene3570	2.746e-80	286.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	phoA	-	3.1.3.2	ko:K14379	ko00740,ko01100,ko04142,ko04380,ko05323,map00740,map01100,map04142,map04380,map05323	-	R00548	RC00017	ko00000,ko00001,ko01000	-	-	-	Metallophos
TLS2_k127_2739219_0	1122931.AUAE01000007_gene1342	4.557e-266	855.0	COG0457@1|root,COG0457@2|Bacteria,4NKMF@976|Bacteroidetes,2FXC5@200643|Bacteroidia,231HD@171551|Porphyromonadaceae	1122931.AUAE01000007_gene1342|-	S	Domain of unknown function (DUF5107)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2742199_2	324602.Caur_1458	1.185e-126	417.0	COG0626@1|root,COG0626@2|Bacteria,2G5M2@200795|Chloroflexi,376G2@32061|Chloroflexia	32061|Chloroflexia	E	PFAM Cys Met metabolism pyridoxal-phosphate-dependent	-	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS2_k127_2742199_1	1111479.AXAR01000003_gene1596	1.788e-138	450.0	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,4HAFQ@91061|Bacilli	91061|Bacilli	E	cystathionine	mccB	GO:0000096,GO:0000098,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008284,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0042127,GO:0043418,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0048518,GO:0048522,GO:0050667,GO:0050789,GO:0050794,GO:0065007,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.4.1.1,4.4.1.2,4.4.1.8	ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00609	R00782,R01001,R01283,R01286,R02408,R04941	RC00056,RC00069,RC00348,RC00382,RC00487,RC00488,RC00710,RC01245,RC02303,RC02814	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU27250	Cys_Met_Meta_PP
TLS2_k127_2742199_0	1137269.AZWL01000048_gene4810	0.0	1032.0	COG3250@1|root,COG3250@2|Bacteria,2IF23@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolases family 2	-	-	-	-	-	-	-	-	-	-	-	-	Bgal_small_N,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TLS2_k127_2742199_4	1131269.AQVV01000015_gene2005	1.184e-30	131.0	COG2802@1|root,COG2802@2|Bacteria	2|Bacteria	S	histone H2A-K13 ubiquitination	lonD	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
TLS2_k127_2742199_3	1307759.JOMJ01000004_gene3067	3.084e-41	153.0	COG1449@1|root,COG1449@2|Bacteria,1PUYM@1224|Proteobacteria,42MQP@68525|delta/epsilon subdivisions,2WKP2@28221|Deltaproteobacteria,2M8R3@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
TLS2_k127_2743873_5	1123242.JH636434_gene5487	2.921e-13	81.0	COG1105@1|root,COG1105@2|Bacteria,2J14C@203682|Planctomycetes	203682|Planctomycetes	H	COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB)	-	-	2.7.1.144	ko:K00917	ko00052,ko01100,map00052,map01100	-	R03236	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS2_k127_2743873_2	1123242.JH636434_gene4858	9.183e-121	392.0	COG5426@1|root,COG5426@2|Bacteria,2J31F@203682|Planctomycetes	203682|Planctomycetes	S	Putative glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
TLS2_k127_2743873_1	234267.Acid_6591	4.8e-307	949.0	COG0591@1|root,COG0591@2|Bacteria,3Y4WN@57723|Acidobacteria	57723|Acidobacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_2743873_0	1125863.JAFN01000001_gene1462	0.0	1050.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
TLS2_k127_2743873_3	1122194.AUHU01000003_gene2272	5.932e-17	85.0	28K42@1|root,2Z9T6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
TLS2_k127_2743873_4	344747.PM8797T_27322	3.141e-15	78.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C,TAT_signal
TLS2_k127_2746994_0	234267.Acid_6970	1.194e-169	537.0	COG0596@1|root,COG0596@2|Bacteria,3Y7BD@57723|Acidobacteria	57723|Acidobacteria	S	Serine aminopeptidase, S33	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
TLS2_k127_2746994_1	1173022.Cri9333_3716	1.921e-59	216.0	COG0406@1|root,COG0406@2|Bacteria,1G0NK@1117|Cyanobacteria,1H7MJ@1150|Oscillatoriales	1117|Cyanobacteria	G	phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
TLS2_k127_2750523_0	335543.Sfum_0763	1.055e-180	578.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran,OEP
TLS2_k127_2750523_1	977880.RALTA_A2353	8.827e-24	111.0	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,2VJVW@28216|Betaproteobacteria,1KHU5@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	nolF	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TLS2_k127_2756283_2	1128398.Curi_c24180	3.633e-29	132.0	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia	186801|Clostridia	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_2756283_3	378806.STAUR_4800	1.283e-24	119.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,439X4@68525|delta/epsilon subdivisions,2X3MK@28221|Deltaproteobacteria,2YWIP@29|Myxococcales	28221|Deltaproteobacteria	T	HAMP domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_2756283_0	1499967.BAYZ01000103_gene3741	5.041e-171	554.0	COG1032@1|root,COG1032@2|Bacteria,2NQ35@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
TLS2_k127_2756283_1	945713.IALB_1840	1.305e-50	185.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Cytochrome_C554,DUF11,SLH
TLS2_k127_2756283_4	1340493.JNIF01000004_gene502	1.767e-22	106.0	COG1322@1|root,COG1322@2|Bacteria,3Y3JC@57723|Acidobacteria	57723|Acidobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2774092_1	1384054.N790_09210	1.625e-41	159.0	COG1595@1|root,COG1595@2|Bacteria,1RI1M@1224|Proteobacteria,1S780@1236|Gammaproteobacteria,1X678@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2774092_0	1267535.KB906767_gene5125	2.473e-50	193.0	COG1595@1|root,COG1595@2|Bacteria,3Y7Q6@57723|Acidobacteria	57723|Acidobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2774092_3	997884.HMPREF1068_02810	5.166e-06	48.0	COG1858@1|root,COG1858@2|Bacteria,4NE50@976|Bacteroidetes,2FR90@200643|Bacteroidia,4APJC@815|Bacteroidaceae	976|Bacteroidetes	C	cytochrome C peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
TLS2_k127_2774578_0	204669.Acid345_3770	5.059e-292	912.0	COG1201@1|root,COG1201@2|Bacteria,3Y348@57723|Acidobacteria,2JIVQ@204432|Acidobacteriia	204432|Acidobacteriia	L	dead deah	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
TLS2_k127_2774578_1	671143.DAMO_3170	1.485e-11	65.0	COG0642@1|root,COG2205@2|Bacteria	671143.DAMO_3170|-	T	PhoQ Sensor	-	-	2.7.13.3	ko:K07640	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	-
TLS2_k127_2779790_4	742738.HMPREF9460_00523	0.0007365	43.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,24NIH@186801|Clostridia,269X0@186813|unclassified Clostridiales	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_2779790_2	497964.CfE428DRAFT_0725	1.952e-29	131.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS2_k127_2779790_0	886293.Sinac_5762	2.601e-75	273.0	COG0673@1|root,COG0673@2|Bacteria,2IWRC@203682|Planctomycetes	203682|Planctomycetes	S	COGs COG0673 dehydrogenase and related protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_2779790_3	667014.Thein_1678	1.372e-24	115.0	COG1943@1|root,COG1943@2|Bacteria,2GI5R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
TLS2_k127_2779790_1	1403819.BATR01000018_gene593	6.899e-53	192.0	COG1680@1|root,COG5297@1|root,COG1680@2|Bacteria,COG5297@2|Bacteria,46TK0@74201|Verrucomicrobia,2IVMJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Protein of unknown function (DUF1593)	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1593
TLS2_k127_2783774_2	69042.WH5701_08609	6.01e-80	271.0	COG0507@1|root,COG0507@2|Bacteria,1G1QN@1117|Cyanobacteria,1GYNK@1129|Synechococcus	1117|Cyanobacteria	L	COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
TLS2_k127_2783774_0	1128421.JAGA01000003_gene2944	4.558e-191	609.0	COG1640@1|root,COG1640@2|Bacteria,2NP2W@2323|unclassified Bacteria	2|Bacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	iJN678.malQ	Glyco_hydro_77
TLS2_k127_2783774_1	861299.J421_4396	7.879e-96	322.0	arCOG09511@1|root,2Z9DH@2|Bacteria	2|Bacteria	S	FRG	-	-	-	-	-	-	-	-	-	-	-	-	FRG
TLS2_k127_2783774_4	797209.ZOD2009_16563	4.473e-41	155.0	arCOG00516@1|root,arCOG00516@2157|Archaea,2XXT7@28890|Euryarchaeota,23WEB@183963|Halobacteria	183963|Halobacteria	S	flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_2783774_5	926549.KI421517_gene3213	4.069e-32	130.0	COG2259@1|root,COG2259@2|Bacteria,4PB3J@976|Bacteroidetes,47V4B@768503|Cytophagia	976|Bacteroidetes	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
TLS2_k127_2783774_3	479434.Sthe_2500	1.638e-76	265.0	COG1478@1|root,COG1478@2|Bacteria,2G5TU@200795|Chloroflexi,27XFS@189775|Thermomicrobia	189775|Thermomicrobia	S	F420-0:Gamma-glutamyl ligase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
TLS2_k127_2783774_6	1121106.JQKB01000008_gene1358	7.093e-23	106.0	COG1920@1|root,COG1920@2|Bacteria,1RJPN@1224|Proteobacteria,2UAA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
TLS2_k127_2784114_2	649747.HMPREF0083_02004	1.303e-125	407.0	COG0752@1|root,COG0752@2|Bacteria,1TPW8@1239|Firmicutes,4HBCF@91061|Bacilli,26TCW@186822|Paenibacillaceae	91061|Bacilli	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
TLS2_k127_2784114_1	204669.Acid345_1195	1.599e-161	532.0	COG0751@1|root,COG0751@2|Bacteria,3Y3KN@57723|Acidobacteria,2JIJ2@204432|Acidobacteriia	204432|Acidobacteriia	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
TLS2_k127_2784114_0	1267535.KB906767_gene3340	1.804e-203	642.0	COG1260@1|root,COG1260@2|Bacteria,3Y325@57723|Acidobacteria,2JIPN@204432|Acidobacteriia	204432|Acidobacteriia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
TLS2_k127_2784114_4	234267.Acid_3589	7.438e-110	367.0	COG1044@1|root,COG1044@2|Bacteria,3Y2JC@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
TLS2_k127_2784114_5	697281.Mahau_0221	3.945e-71	252.0	COG0598@1|root,COG0598@2|Bacteria,1TPSV@1239|Firmicutes,24DE3@186801|Clostridia,42F3P@68295|Thermoanaerobacterales	186801|Clostridia	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
TLS2_k127_2784114_3	880072.Desac_2552	6.519e-121	407.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2MQKP@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TLS2_k127_2784114_6	1047013.AQSP01000138_gene1079	4.407e-35	140.0	COG4974@1|root,COG4974@2|Bacteria,2NNN8@2323|unclassified Bacteria	2|Bacteria	L	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_27845_1	234267.Acid_1509	1.348e-71	252.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_27845_0	1340493.JNIF01000003_gene1814	4.801e-125	441.0	COG3485@1|root,COG3485@2|Bacteria,3Y3FU@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_27845_2	880070.Cycma_1902	2.52e-53	215.0	28MHM@1|root,2ZAUH@2|Bacteria,4NKMG@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_27845_3	556261.HMPREF0240_00555	2.706e-27	119.0	COG0407@1|root,COG0407@2|Bacteria,1URPV@1239|Firmicutes,24XIW@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TLS2_k127_2786934_0	1249627.D779_0686	1.41e-20	108.0	COG4625@1|root,COG4625@2|Bacteria	2|Bacteria	T	pathogenesis	yapH	-	-	ko:K12685,ko:K19231	-	-	-	-	ko00000,ko01000,ko02000,ko02044	1.B.12,1.B.12.5.1,1.B.12.5.3	-	-	Autotransporter,PAP2,PATR,Peptidase_S8
TLS2_k127_2790579_0	1121904.ARBP01000008_gene3236	2.138e-31	141.0	COG5512@1|root,COG5512@2|Bacteria,4NHWD@976|Bacteroidetes,47N4B@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
TLS2_k127_2802972_1	1267535.KB906767_gene2753	6.019e-35	139.0	COG2365@1|root,COG2365@2|Bacteria	2|Bacteria	T	protein tyrosine phosphatase activity	iphP	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Y_phosphatase3
TLS2_k127_2802972_0	234267.Acid_4891	2.269e-138	463.0	COG1132@1|root,COG1132@2|Bacteria,3Y6PT@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
TLS2_k127_2815865_0	869213.JCM21142_93371	6.763e-89	305.0	COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,47KQM@768503|Cytophagia	976|Bacteroidetes	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
TLS2_k127_2815865_2	1288963.ADIS_1639	2.575e-53	203.0	28KKU@1|root,2ZA5K@2|Bacteria,4P1X6@976|Bacteroidetes	976|Bacteroidetes	S	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase
TLS2_k127_2815865_1	871968.DESME_15085	9.639e-81	287.0	COG1680@1|root,COG1680@2|Bacteria,1UZZ5@1239|Firmicutes,25BFU@186801|Clostridia	186801|Clostridia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_2815865_3	338966.Ppro_1005	1.573e-11	67.0	COG1403@1|root,COG1403@2|Bacteria,1RAJZ@1224|Proteobacteria	1224|Proteobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_4
TLS2_k127_2830228_1	658659.HMPREF0983_00640	1.781e-41	158.0	COG1971@1|root,COG1971@2|Bacteria,1V4QK@1239|Firmicutes,3VQI6@526524|Erysipelotrichia	526524|Erysipelotrichia	P	Probably functions as a manganese efflux pump	mntP	-	-	-	-	-	-	-	-	-	-	-	Mntp
TLS2_k127_2830228_0	1267533.KB906737_gene1879	1.727e-48	194.0	COG0457@1|root,COG0457@2|Bacteria,3Y74E@57723|Acidobacteria,2JK7F@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
TLS2_k127_2834949_1	452637.Oter_2150	2.616e-75	261.0	COG1995@1|root,COG1995@2|Bacteria,46SNQ@74201|Verrucomicrobia,3K7JT@414999|Opitutae	74201|Verrucomicrobia	C	Belongs to the PdxA family	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
TLS2_k127_2834949_0	366602.Caul_3781	1.892e-128	421.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria,2KHNW@204458|Caulobacterales	204458|Caulobacterales	C	PFAM iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
TLS2_k127_2834949_2	180332.JTGN01000016_gene1024	2.196e-16	87.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TLS2_k127_2836731_0	1047013.AQSP01000133_gene2142	1.481e-146	469.0	COG0451@1|root,COG0451@2|Bacteria,2NPS7@2323|unclassified Bacteria	2|Bacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_2836731_1	1128421.JAGA01000001_gene2450	3.797e-121	398.0	COG1613@1|root,COG1613@2|Bacteria,2NQGY@2323|unclassified Bacteria	2|Bacteria	P	Bacterial extracellular solute-binding protein	subI	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	iJN678.sbpA	SBP_bac_11
TLS2_k127_2840249_1	396595.TK90_0617	9.892e-54	210.0	COG1132@1|root,COG1132@2|Bacteria,1MVJD@1224|Proteobacteria,1RQDM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
TLS2_k127_2840249_0	1453500.AT05_10680	8.693e-181	569.0	COG0451@1|root,COG0451@2|Bacteria,4NEZX@976|Bacteroidetes,1HWT7@117743|Flavobacteriia	976|Bacteroidetes	GM	PFAM NAD dependent epimerase dehydratase family	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_2846337_1	1121012.AUKX01000038_gene3730	4.984e-78	264.0	COG0160@1|root,COG0160@2|Bacteria,4NIHH@976|Bacteroidetes,1IG0C@117743|Flavobacteriia,23ICM@178469|Arenibacter	976|Bacteroidetes	E	Aminotransferase class-III	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_2846337_0	661478.OP10G_3052	1.648e-142	462.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_2850753_0	1121405.dsmv_3003	4.025e-264	823.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	glycosyltransferase 36 associated	-	-	2.4.1.20	ko:K00702,ko:K13688	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000,ko01003	-	GH94,GT36,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
TLS2_k127_2851371_0	234267.Acid_0199	7.134e-84	286.0	COG3836@1|root,COG3836@2|Bacteria	2|Bacteria	G	2-keto-3-deoxy-L-rhamnonate aldolase activity	hpcH	-	2.7.7.38,4.1.2.20,4.1.2.52	ko:K00979,ko:K01630,ko:K02510	ko00053,ko00350,ko00540,ko01100,ko01120,map00053,map00350,map00540,map01100,map01120	M00063	R01645,R01647,R02754,R03277,R03351,R11396	RC00152,RC00307,RC00435,RC00572,RC00574,RC00910,RC03057	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	HpcH_HpaI
TLS2_k127_2851371_1	357808.RoseRS_0010	3.325e-52	207.0	COG0823@1|root,COG0823@2|Bacteria,2G8T5@200795|Chloroflexi,376FH@32061|Chloroflexia	32061|Chloroflexia	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
TLS2_k127_2855117_1	118163.Ple7327_3881	3.326e-183	584.0	COG1215@1|root,COG1215@2|Bacteria,1GCIQ@1117|Cyanobacteria,3VM6Z@52604|Pleurocapsales	1117|Cyanobacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
TLS2_k127_2855117_3	926569.ANT_15820	5.098e-94	334.0	COG0110@1|root,COG0110@2|Bacteria,2G6D2@200795|Chloroflexi	200795|Chloroflexi	S	PFAM transferase hexapeptide repeat containing protein	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
TLS2_k127_2855117_2	926550.CLDAP_36260	9.082e-123	419.0	COG0463@1|root,COG0463@2|Bacteria,2G7KQ@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_2855117_0	926550.CLDAP_36250	7.012e-241	755.0	COG1032@1|root,COG1032@2|Bacteria,2G5SI@200795|Chloroflexi	200795|Chloroflexi	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_2855117_5	1479239.JQMU01000002_gene34	1.916e-10	72.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,2TT1Y@28211|Alphaproteobacteria,2K00D@204457|Sphingomonadales	204457|Sphingomonadales	D	protein involved in exopolysaccharide biosynthesis	-	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
TLS2_k127_2855296_4	1238450.VIBNISOn1_1270004	1.951e-09	62.0	COG2610@1|root,COG2610@2|Bacteria,1MUFG@1224|Proteobacteria,1RNGE@1236|Gammaproteobacteria,1XVND@135623|Vibrionales	135623|Vibrionales	EG	COG2610 H gluconate symporter and related permeases	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
TLS2_k127_2855296_1	234267.Acid_5934	1.826e-163	522.0	COG0697@1|root,2Z7ID@2|Bacteria,3Y46C@57723|Acidobacteria	57723|Acidobacteria	EG	PFAM RhaT l-rhamnose-proton symport 2	-	-	-	ko:K02856	-	-	-	-	ko00000,ko02000	2.A.7.6	-	-	RhaT
TLS2_k127_2855296_0	1047013.AQSP01000142_gene240	3.951e-236	747.0	COG3533@1|root,COG3533@2|Bacteria,2NNW0@2323|unclassified Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	F5_F8_type_C,Glyco_hydro_127
TLS2_k127_2855296_2	1227487.C474_16159	6.927e-103	355.0	arCOG02521@1|root,arCOG02521@2157|Archaea,2XVSU@28890|Euryarchaeota,23UVK@183963|Halobacteria	183963|Halobacteria	S	Glycosyl hydrolases family 28	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28
TLS2_k127_2855296_3	926554.KI912631_gene3582	9.617e-27	115.0	COG2335@1|root,COG2335@2|Bacteria,1WMNY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	COG2335 Secreted and surface protein containing fasciclin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
TLS2_k127_2855332_1	460265.Mnod_2965	2.361e-108	361.0	COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2TUT7@28211|Alphaproteobacteria,1JSXA@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM 2-nitropropane dioxygenase NPD	-	-	1.13.12.16,1.3.1.9	ko:K00459,ko:K02371	ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212	M00083	R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076,RC02541,RC02759	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
TLS2_k127_2855332_2	1121447.JONL01000001_gene1051	1.906e-25	111.0	COG2731@1|root,COG2731@2|Bacteria,1N8IZ@1224|Proteobacteria,42W19@68525|delta/epsilon subdivisions,2WTDM@28221|Deltaproteobacteria,2MD7E@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Domain of unknown function (DUF386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF386
TLS2_k127_2855332_0	1380367.JIBC01000006_gene623	1.902e-173	570.0	COG2304@1|root,COG2304@2|Bacteria,1PBVT@1224|Proteobacteria,2U3NK@28211|Alphaproteobacteria,3ZVJC@60136|Sulfitobacter	28211|Alphaproteobacteria	S	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
TLS2_k127_2857252_3	1231185.BAMP01000005_gene3932	9.769e-11	66.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2TUUZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2857252_2	523791.Kkor_0401	4.025e-18	89.0	COG5660@1|root,COG5660@2|Bacteria,1NCWT@1224|Proteobacteria,1SDFE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_2857252_1	1036674.A28LD_1047	2.044e-36	140.0	COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,1S62I@1236|Gammaproteobacteria,2QGXP@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
TLS2_k127_2857252_0	518766.Rmar_1427	6.748e-167	528.0	COG0365@1|root,COG0365@2|Bacteria,4NEAD@976|Bacteroidetes,1FIMS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_2861598_0	1298863.AUEP01000004_gene2100	1.34e-49	199.0	COG0367@1|root,COG0367@2|Bacteria,2GJIM@201174|Actinobacteria,4DQH7@85009|Propionibacteriales	201174|Actinobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
TLS2_k127_2861598_1	665571.STHERM_c20580	6.64e-07	63.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.78	ko:K19355	ko00051,map00051	-	R01332	RC00467	ko00000,ko00001,ko01000	-	-	-	Cellulase,DUF5060
TLS2_k127_2862414_2	204669.Acid345_4117	2.385e-48	179.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
TLS2_k127_2862414_0	1267535.KB906767_gene3678	5.029e-298	920.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_2863301_2	1347342.BN863_10260	5.665e-07	55.0	COG0657@1|root,COG0657@2|Bacteria,4NJ8D@976|Bacteroidetes,1HZX0@117743|Flavobacteriia	976|Bacteroidetes	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,DLH,Lipase_GDSL_2,Peptidase_S9
TLS2_k127_2863301_1	1267535.KB906767_gene1700	1.661e-12	75.0	COG2706@1|root,COG2706@2|Bacteria	2|Bacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,He_PIG,Lactonase,VCBS
TLS2_k127_2863301_0	686340.Metal_0215	2.075e-117	398.0	2DUCG@1|root,33PYM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2891143_5	1540221.JQNI01000004_gene324	1.766e-48	177.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	rfaF	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TLS2_k127_2891143_1	211165.AJLN01000104_gene6512	2.658e-144	474.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1G2IU@1117|Cyanobacteria,1JHCD@1189|Stigonemataceae	1117|Cyanobacteria	IM	pfkB family carbohydrate kinase	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
TLS2_k127_2891143_4	1183438.GKIL_0946	4.486e-70	250.0	COG0241@1|root,COG0241@2|Bacteria,1G50D@1117|Cyanobacteria	1117|Cyanobacteria	E	Polynucleotide kinase 3 phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_like
TLS2_k127_2891143_3	306281.AJLK01000057_gene4466	5.961e-88	299.0	COG4221@1|root,COG4221@2|Bacteria,1G00V@1117|Cyanobacteria,1JKAG@1189|Stigonemataceae	1117|Cyanobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_2891143_0	221288.JH992901_gene4586	2.599e-215	687.0	COG0279@1|root,COG0438@1|root,COG0279@2|Bacteria,COG0438@2|Bacteria,1G1I9@1117|Cyanobacteria,1JHY0@1189|Stigonemataceae	1117|Cyanobacteria	GM	SIS domain	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Glyco_transf_4,Glycos_transf_1,SIS_2
TLS2_k127_2891143_2	1476583.DEIPH_ctg011orf0137	1.186e-141	458.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	rfaG	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
TLS2_k127_2897182_2	204669.Acid345_1029	4.131e-11	70.0	2DMGW@1|root,32REM@2|Bacteria,3Y4XX@57723|Acidobacteria,2JJER@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-B_box
TLS2_k127_2897182_0	1232410.KI421413_gene478	1.901e-99	335.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,42UYG@68525|delta/epsilon subdivisions,2WR4P@28221|Deltaproteobacteria,43V2Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_2897182_3	1267535.KB906767_gene3216	3.094e-05	54.0	COG2823@1|root,COG2823@2|Bacteria,3Y3MJ@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS2_k127_2897182_1	1192034.CAP_5044	6.765e-61	225.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1N58A@1224|Proteobacteria,43AW0@68525|delta/epsilon subdivisions,2X6A6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_2900416_2	714943.Mucpa_6778	9.887e-73	252.0	COG0591@1|root,COG0591@2|Bacteria,4NEN8@976|Bacteroidetes,1IP0U@117747|Sphingobacteriia	976|Bacteroidetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
TLS2_k127_2900416_1	485917.Phep_0522	4.55e-80	278.0	COG0329@1|root,COG0329@2|Bacteria,4NFIH@976|Bacteroidetes,1IQG0@117747|Sphingobacteriia	976|Bacteroidetes	H	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_2900416_0	1267535.KB906767_gene1814	5.647e-206	676.0	COG1629@1|root,COG4771@2|Bacteria,3Y7GJ@57723|Acidobacteria,2JM2Q@204432|Acidobacteriia	204432|Acidobacteriia	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_2910589_1	234267.Acid_1518	3.327e-80	278.0	COG0673@1|root,COG0673@2|Bacteria,3Y74B@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.335	ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_2910589_0	765420.OSCT_1972	6.04e-104	356.0	COG1506@1|root,COG1506@2|Bacteria,2GAHG@200795|Chloroflexi,377JQ@32061|Chloroflexia	32061|Chloroflexia	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
TLS2_k127_2911975_0	945713.IALB_3112	0.0	1323.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
TLS2_k127_2911975_2	1394178.AWOO02000059_gene591	8.137e-56	208.0	COG2146@1|root,COG2146@2|Bacteria,2I1BQ@201174|Actinobacteria,4EFMN@85012|Streptosporangiales	201174|Actinobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231,Rieske
TLS2_k127_2911975_1	706587.Desti_1267	8.079e-144	464.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2MQAG@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
TLS2_k127_2913239_1	913865.DOT_0063	3.431e-24	104.0	COG3682@1|root,COG3682@2|Bacteria,1V7EY@1239|Firmicutes,24N11@186801|Clostridia,265AW@186807|Peptococcaceae	186801|Clostridia	K	PFAM Penicillinase repressor	blaI	-	-	ko:K02171	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01504,ko03000	-	-	-	Penicillinase_R
TLS2_k127_2913239_0	794903.OPIT5_29480	6.595e-71	269.0	COG0526@1|root,COG2373@1|root,COG4219@1|root,COG0526@2|Bacteria,COG2373@2|Bacteria,COG4219@2|Bacteria,46XN8@74201|Verrucomicrobia,3K9XB@414999|Opitutae	414999|Opitutae	KT	BlaR1 peptidase M56	-	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	Peptidase_M56
TLS2_k127_2914164_3	525897.Dbac_1905	4.704e-31	123.0	COG0640@1|root,COG0640@2|Bacteria,1N19R@1224|Proteobacteria,42TRS@68525|delta/epsilon subdivisions,2WQHU@28221|Deltaproteobacteria,2MC8X@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	SMART regulatory protein ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS2_k127_2914164_0	1499967.BAYZ01000050_gene2840	1.379e-192	611.0	COG0701@1|root,COG0701@2|Bacteria,2NP6A@2323|unclassified Bacteria	2|Bacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
TLS2_k127_2914164_4	1499967.BAYZ01000050_gene2876	4.529e-30	128.0	COG0526@1|root,COG0526@2|Bacteria,2NQ68@2323|unclassified Bacteria	2|Bacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	resA_1	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_2914164_1	319224.Sputcn32_3833	1.904e-63	226.0	COG4232@1|root,COG4232@2|Bacteria,1QJ3E@1224|Proteobacteria,1TH0Z@1236|Gammaproteobacteria,2QDT4@267890|Shewanellaceae	1236|Gammaproteobacteria	CO	PFAM cytochrome c biogenesis protein, transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
TLS2_k127_2914164_5	795359.TOPB45_0890	5.439e-18	92.0	COG0526@1|root,COG0526@2|Bacteria,2GI1G@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	CO	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
TLS2_k127_2914164_2	565045.NOR51B_2328	3.695e-52	192.0	COG1228@1|root,COG1228@2|Bacteria,1MY4V@1224|Proteobacteria,1RZRK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_2921673_1	1379698.RBG1_1C00001G1345	1.479e-91	326.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2NQ3V@2323|unclassified Bacteria	2|Bacteria	KT	COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit	rsbU	-	3.1.3.3,4.6.1.1	ko:K01768,ko:K07315	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	GAF,GAF_2,HATPase_c_2,SSF,SpoIIE
TLS2_k127_2921673_3	583355.Caka_2450	7.152e-08	59.0	28X6Y@1|root,2ZJ59@2|Bacteria,46WIZ@74201|Verrucomicrobia,3K8DC@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2921673_0	357808.RoseRS_2742	1.815e-127	418.0	COG2957@1|root,COG2957@2|Bacteria,2GAHD@200795|Chloroflexi,37657@32061|Chloroflexia	32061|Chloroflexia	E	Belongs to the agmatine deiminase family	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
TLS2_k127_2921673_2	886293.Sinac_3542	8.582e-73	248.0	COG0388@1|root,COG0388@2|Bacteria,2IX91@203682|Planctomycetes	203682|Planctomycetes	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
TLS2_k127_2928029_1	1540221.JQNI01000004_gene439	6.061e-195	615.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_2928029_0	234267.Acid_0349	0.0	1092.0	COG0438@1|root,COG1232@1|root,COG0438@2|Bacteria,COG1232@2|Bacteria	2|Bacteria	H	protoporphyrinogen oxidase activity	tuaH	-	5.4.99.9	ko:K01854,ko:K07011	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,GLF,Glyco_trans_1_4,NAD_binding_8
TLS2_k127_2929341_1	234267.Acid_1509	2.963e-139	458.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2929341_0	767817.Desgi_1992	4.698e-158	519.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,260EY@186807|Peptococcaceae	186801|Clostridia	S	PFAM Uncharacterised protein family UPF0182	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
TLS2_k127_2929632_3	1449350.OCH239_17255	2.413e-15	86.0	COG5635@1|root,COG5635@2|Bacteria,1N7XU@1224|Proteobacteria	1224|Proteobacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4062
TLS2_k127_2929632_1	745776.DGo_CA1980	4.573e-30	130.0	2D62R@1|root,32TKD@2|Bacteria	2|Bacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
TLS2_k127_2929632_0	886293.Sinac_3471	3.638e-40	153.0	COG2194@1|root,COG2194@2|Bacteria,2J38R@203682|Planctomycetes	203682|Planctomycetes	S	sulfuric ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2932791_5	1403819.BATR01000146_gene5012	4.075e-44	168.0	COG0673@1|root,COG0673@2|Bacteria,46UJ9@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_2932791_6	644283.Micau_5001	3.202e-26	111.0	COG3576@1|root,COG3576@2|Bacteria,2IKU6@201174|Actinobacteria	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_2932791_2	266779.Meso_2424	2.642e-141	455.0	COG4294@1|root,COG4294@2|Bacteria,1R4A5@1224|Proteobacteria,2TU71@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	UV-endonuclease UvdE	-	-	-	ko:K13281	-	-	-	-	ko00000,ko01000	-	-	-	UvdE
TLS2_k127_2932791_3	670292.JH26_21400	8.002e-92	313.0	COG0608@1|root,COG0608@2|Bacteria,1NTFD@1224|Proteobacteria,2UPPA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	single-stranded DNA 5'-3' exodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2932791_0	1408473.JHXO01000010_gene3552	5e-324	1008.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMCU@200643|Bacteroidia	976|Bacteroidetes	G	Glycosyl hydrolase family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
TLS2_k127_2932791_1	754027.HMPREF9554_02914	1.146e-203	651.0	COG0205@1|root,COG0205@2|Bacteria,2J60A@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135	2.7.1.90	ko:K00895	ko00010,ko00030,ko00051,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map01100,map01110,map01120,map01130	-	R00764,R02073	RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
TLS2_k127_2932791_4	1429916.X566_21020	6.155e-47	171.0	COG0652@1|root,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
TLS2_k127_2939632_2	1210884.HG799463_gene10215	4.297e-06	57.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_2939632_0	269799.Gmet_2892	1.037e-109	366.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42MCE@68525|delta/epsilon subdivisions,2WIYP@28221|Deltaproteobacteria,43U7K@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
TLS2_k127_2939632_1	1340493.JNIF01000004_gene849	9.883e-19	88.0	COG1975@1|root,COG1975@2|Bacteria,3Y54Y@57723|Acidobacteria	57723|Acidobacteria	O	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS2_k127_2940366_0	518766.Rmar_0076	6.584e-236	743.0	28I5V@1|root,2Z891@2|Bacteria,4NF4U@976|Bacteroidetes	976|Bacteroidetes	G	Glycosyl hydrolase family 9	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,Glyco_hydro_9
TLS2_k127_2951243_3	234267.Acid_0653	1.756e-05	47.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
TLS2_k127_2951243_0	234267.Acid_4705	1.89e-124	406.0	COG0320@1|root,COG0320@2|Bacteria,3Y3D4@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
TLS2_k127_2951243_1	1123242.JH636435_gene2134	8.147e-109	376.0	COG1914@1|root,COG1914@2|Bacteria,2IYEM@203682|Planctomycetes	2|Bacteria	P	H( )-stimulated, divalent metal cation uptake system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2951243_2	234267.Acid_1990	1.124e-56	209.0	COG1629@1|root,COG4771@2|Bacteria,3Y3YH@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_2952581_3	595460.RRSWK_05376	0.0002548	53.0	COG1409@1|root,COG1409@2|Bacteria,2J2E9@203682|Planctomycetes	203682|Planctomycetes	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Metallophos
TLS2_k127_2952581_1	515635.Dtur_0646	8.406e-34	141.0	COG3718@1|root,COG3718@2|Bacteria	2|Bacteria	G	enzyme involved in inositol metabolism	iolB	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
TLS2_k127_2952581_0	1134413.ANNK01000002_gene2941	6.192e-38	154.0	COG1082@1|root,COG1082@2|Bacteria,1TRGF@1239|Firmicutes,4IRV2@91061|Bacilli,1ZE33@1386|Bacillus	91061|Bacilli	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_2952581_2	1288963.ADIS_1786	1.364e-09	62.0	COG3408@1|root,COG3408@2|Bacteria,4NGV6@976|Bacteroidetes,47MN4@768503|Cytophagia	976|Bacteroidetes	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_2954371_3	204669.Acid345_0248	8.887e-23	104.0	COG4775@1|root,COG4775@2|Bacteria,3Y2Q9@57723|Acidobacteria,2JHYD@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM outer membrane protein assembly complex, YaeT protein	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TLS2_k127_2954371_4	404589.Anae109_1121	1.272e-12	76.0	COG2825@1|root,COG2825@2|Bacteria,1MZVJ@1224|Proteobacteria,42VH3@68525|delta/epsilon subdivisions,2WP6K@28221|Deltaproteobacteria,2YVZ7@29|Myxococcales	28221|Deltaproteobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
TLS2_k127_2954371_0	880072.Desac_2717	2.904e-87	299.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2WJJY@28221|Deltaproteobacteria,2MQC0@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
TLS2_k127_2954371_2	574087.Acear_2192	7.177e-52	188.0	COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,24JAW@186801|Clostridia,3WAS4@53433|Halanaerobiales	186801|Clostridia	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
TLS2_k127_2954371_1	1232410.KI421414_gene2841	5.152e-63	222.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2WJVP@28221|Deltaproteobacteria,43RXH@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
TLS2_k127_295744_3	330214.NIDE3149	7.182e-28	114.0	COG4149@1|root,COG4149@2|Bacteria	2|Bacteria	P	molybdate abc transporter	modB	-	-	ko:K02018,ko:K15496	ko02010,map02010	M00189,M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.5,3.A.1.8	-	-	BPD_transp_1
TLS2_k127_295744_0	518766.Rmar_0054	1.43e-95	327.0	COG4148@1|root,COG4148@2|Bacteria	2|Bacteria	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
TLS2_k127_295744_4	344747.PM8797T_05900	2.181e-22	113.0	COG1807@1|root,COG1807@2|Bacteria,2IX04@203682|Planctomycetes	203682|Planctomycetes	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_295744_1	493475.GARC_4567	4.182e-61	221.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,465TH@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
TLS2_k127_295744_5	880073.Calab_1581	4.344e-19	103.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3,HlyD_D23
TLS2_k127_295744_2	1117315.AHCA01000001_gene2404	1.855e-40	172.0	COG0845@1|root,COG0845@2|Bacteria,1R78S@1224|Proteobacteria,1S0GJ@1236|Gammaproteobacteria,2Q00I@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3,HlyD_D23
TLS2_k127_295744_6	1511.CLOST_2550	0.0005927	51.0	COG0845@1|root,COG0845@2|Bacteria,1V996@1239|Firmicutes,24M4Q@186801|Clostridia	186801|Clostridia	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
TLS2_k127_2968844_1	658086.HMPREF0994_06084	8.396e-46	183.0	COG3533@1|root,COG3533@2|Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Alginate_lyase,CBM_35,Glyco_hydro_127,Glyco_hydro_25,Laminin_G_3,Methyltransf_11,Prenyltrans,RHS_repeat,RicinB_lectin_2
TLS2_k127_2968844_0	1121396.KB893123_gene1084	1.853e-49	195.0	COG2197@1|root,COG2202@1|root,COG4585@1|root,COG2197@2|Bacteria,COG2202@2|Bacteria,COG4585@2|Bacteria,1NWNJ@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HATPase_c,HTH_3,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3
TLS2_k127_2968844_2	644283.Micau_6186	5.92e-08	63.0	COG4714@1|root,COG4714@2|Bacteria	2|Bacteria	EGP	membrane-anchored protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
TLS2_k127_3017664_0	1200792.AKYF01000019_gene4490	9.181e-70	245.0	2C7PT@1|root,2ZXN2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3017664_1	500153.JOEK01000008_gene2377	4.839e-06	50.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_3028963_1	1267533.KB906733_gene3119	1.429e-38	160.0	COG0457@1|root,COG0457@2|Bacteria,3Y2IK@57723|Acidobacteria,2JKNM@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8,UnbV_ASPIC,VCBS
TLS2_k127_3028963_0	247490.KSU1_C0542	7.094e-141	456.0	COG1415@1|root,COG1415@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF763)	MA20_26605	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
TLS2_k127_3028963_2	1232437.KL661953_gene2314	1.497e-36	143.0	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,42S1N@68525|delta/epsilon subdivisions,2WNUH@28221|Deltaproteobacteria,2MJVE@213118|Desulfobacterales	28221|Deltaproteobacteria	O	TIGRFAM thioredoxin	trx-3	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
TLS2_k127_3028963_3	1121481.AUAS01000018_gene413	2.511e-07	56.0	COG1487@1|root,COG1487@2|Bacteria,4NSBY@976|Bacteroidetes,47X56@768503|Cytophagia	976|Bacteroidetes	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
TLS2_k127_3033387_2	589865.DaAHT2_0263	7.364e-67	242.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42QM3@68525|delta/epsilon subdivisions,2WKI2@28221|Deltaproteobacteria,2MI4S@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
TLS2_k127_3033387_3	1123325.JHUV01000011_gene1381	2.704e-35	140.0	COG0703@1|root,COG0703@2|Bacteria,2G46N@200783|Aquificae	200783|Aquificae	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
TLS2_k127_3033387_0	234267.Acid_7333	3.137e-118	393.0	COG0128@1|root,COG0128@2|Bacteria,3Y3RH@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TLS2_k127_3033387_1	204669.Acid345_1782	8.939e-88	295.0	COG0556@1|root,COG0556@2|Bacteria,3Y31K@57723|Acidobacteria,2JHY9@204432|Acidobacteriia	204432|Acidobacteriia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
TLS2_k127_3045354_3	1047013.AQSP01000067_gene2200	5.867e-15	80.0	COG3379@1|root,COG3379@2|Bacteria,2NQA7@2323|unclassified Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_3045354_1	1267535.KB906767_gene5001	5.523e-94	338.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,Sulfatase
TLS2_k127_3045354_2	204669.Acid345_2317	1.219e-35	140.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	-	-	2.7.11.1	ko:K04757,ko:K17752	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c,HATPase_c_2,Response_reg,SpoIIE
TLS2_k127_3045354_0	929562.Emtol_1353	6.184e-170	550.0	COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,47KC3@768503|Cytophagia	976|Bacteroidetes	Q	PFAM D-aminoacylase, C-terminal region	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
TLS2_k127_3045828_0	234267.Acid_7380	5.895e-96	344.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y3HX@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,TPR_8
TLS2_k127_3046173_2	886293.Sinac_5815	1.112e-09	67.0	COG1073@1|root,COG1506@1|root,COG1073@2|Bacteria,COG1506@2|Bacteria,2IXK0@203682|Planctomycetes	203682|Planctomycetes	E	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
TLS2_k127_3046173_1	1122132.AQYH01000008_gene2457	1.142e-27	121.0	COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria,4B9S8@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF541)	omp28	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
TLS2_k127_3046173_0	204669.Acid345_4155	5.752e-32	128.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria,2JIZ4@204432|Acidobacteriia	204432|Acidobacteriia	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_3048552_3	1288963.ADIS_3068	1.667e-55	201.0	COG3458@1|root,COG3458@2|Bacteria,4NJMX@976|Bacteroidetes,47TKJ@768503|Cytophagia	976|Bacteroidetes	Q	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
TLS2_k127_3048552_5	1517681.HW45_16765	5.654e-13	78.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,1XSEV@135623|Vibrionales	135623|Vibrionales	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_23
TLS2_k127_3048552_4	1128421.JAGA01000003_gene2880	7.722e-25	111.0	2ASAK@1|root,31HPU@2|Bacteria,2NQ6K@2323|unclassified Bacteria	2|Bacteria	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
TLS2_k127_3048552_2	1128421.JAGA01000003_gene2879	1.153e-72	251.0	COG1845@1|root,COG1845@2|Bacteria,2NPIG@2323|unclassified Bacteria	2|Bacteria	C	cytochrome c oxidase subunit III	coxC	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
TLS2_k127_3048552_0	1123242.JH636434_gene3641	1.302e-272	848.0	COG0843@1|root,COG0843@2|Bacteria,2IXCQ@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS2_k127_3048552_1	234267.Acid_0497	3.685e-118	394.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,3Y2GR@57723|Acidobacteria	57723|Acidobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C,Cytochrome_CBB3
TLS2_k127_3048552_6	204669.Acid345_2997	5.044e-09	58.0	COG1999@1|root,COG1999@2|Bacteria,3Y3XH@57723|Acidobacteria,2JIUU@204432|Acidobacteriia	204432|Acidobacteriia	S	signal sequence binding	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	-
TLS2_k127_306005_2	795359.TOPB45_0572	1.049e-05	50.0	COG1032@1|root,COG1032@2|Bacteria,2GGRT@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_306005_0	1191523.MROS_0843	3.792e-184	587.0	COG1271@1|root,COG1271@2|Bacteria	2|Bacteria	C	aerobic electron transport chain	cydA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	iPC815.YPO1117,iSBO_1134.SBO_2253,iSFxv_1172.SFxv_0621,iS_1188.S0577,iSbBS512_1146.SbBS512_E2337	Cyt_bd_oxida_I
TLS2_k127_306005_1	1191523.MROS_0842	1.559e-112	373.0	COG1294@1|root,COG1294@2|Bacteria	2|Bacteria	C	oxidative phosphorylation	cydB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iPC815.YPO1118,ic_1306.c1120	Cyt_bd_oxida_II
TLS2_k127_3064827_1	443144.GM21_2588	2.072e-85	293.0	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,42PPG@68525|delta/epsilon subdivisions,2WJGF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS2_k127_3064827_0	314345.SPV1_00240	2.238e-99	339.0	COG0438@1|root,COG0438@2|Bacteria,1N0DG@1224|Proteobacteria	1224|Proteobacteria	M	Glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_3064827_2	1132855.KB913035_gene1654	3.502e-69	245.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	1.1.1.412,5.1.3.26	ko:K19997,ko:K22320	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
TLS2_k127_3064827_3	1246626.BleG1_3552	1.168e-54	200.0	COG0463@1|root,COG0463@2|Bacteria,1UIVJ@1239|Firmicutes	1239|Firmicutes	M	group 2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_3064827_4	504472.Slin_4931	4.044e-45	177.0	COG1216@1|root,COG1216@2|Bacteria,4NNIR@976|Bacteroidetes,47S78@768503|Cytophagia	976|Bacteroidetes	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_3070293_0	1288963.ADIS_0344	2.038e-82	290.0	COG3616@1|root,COG3616@2|Bacteria	2|Bacteria	E	Alanine racemase, N-terminal domain	dhaa	-	4.1.2.42,4.1.3.41	ko:K18425,ko:K19967	-	-	-	-	ko00000,ko01000	-	-	-	Ala_racemase_N,D-ser_dehydrat
TLS2_k127_3070293_1	1499967.BAYZ01000048_gene2693	5.805e-82	281.0	COG0488@1|root,COG0488@2|Bacteria	2|Bacteria	L	(ABC) transporter	-	-	-	ko:K15738,ko:K18231	ko02010,map02010	-	-	-	br01600,ko00000,ko00001,ko01504,ko02000	3.A.1.120.6,3.A.1.121.1,3.A.1.121.3	-	-	ABC_tran
TLS2_k127_3080174_2	7370.XP_005187019.1	7.308e-10	70.0	COG0457@1|root,KOG1126@2759|Eukaryota,38DG8@33154|Opisthokonta,3BENB@33208|Metazoa,3CWDT@33213|Bilateria,41TXT@6656|Arthropoda,3SFUT@50557|Insecta,44XXJ@7147|Diptera	33208|Metazoa	D	Anaphase-promoting complex, cyclosome, subunit 3	CDC27	GO:0000003,GO:0000151,GO:0000152,GO:0000209,GO:0000278,GO:0000375,GO:0000377,GO:0000398,GO:0001775,GO:0003002,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005680,GO:0005737,GO:0005813,GO:0005815,GO:0005819,GO:0005829,GO:0005856,GO:0006139,GO:0006396,GO:0006397,GO:0006464,GO:0006508,GO:0006511,GO:0006725,GO:0006807,GO:0006810,GO:0006887,GO:0007049,GO:0007088,GO:0007091,GO:0007275,GO:0007338,GO:0007343,GO:0007346,GO:0007389,GO:0008150,GO:0008152,GO:0008283,GO:0008356,GO:0008380,GO:0009056,GO:0009057,GO:0009566,GO:0009798,GO:0009948,GO:0009949,GO:0009952,GO:0009987,GO:0010467,GO:0010498,GO:0010564,GO:0010965,GO:0015630,GO:0016070,GO:0016071,GO:0016192,GO:0016567,GO:0016740,GO:0017156,GO:0019538,GO:0019787,GO:0019899,GO:0019902,GO:0019903,GO:0019941,GO:0019953,GO:0022402,GO:0022414,GO:0030163,GO:0031145,GO:0031461,GO:0031974,GO:0031981,GO:0032446,GO:0032501,GO:0032502,GO:0032940,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0034641,GO:0036211,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043632,GO:0043900,GO:0043901,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044770,GO:0044772,GO:0044784,GO:0045055,GO:0046483,GO:0046903,GO:0048519,GO:0048856,GO:0050789,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0051603,GO:0051704,GO:0051726,GO:0051783,GO:0051983,GO:0060467,GO:0060468,GO:0060471,GO:0061630,GO:0061659,GO:0065001,GO:0065007,GO:0070013,GO:0070647,GO:0070979,GO:0071704,GO:0080154,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1903047,GO:1905818,GO:1990234,GO:2000241,GO:2000242	-	ko:K03350	ko04110,ko04111,ko04113,ko04114,ko04120,ko04914,ko05166,map04110,map04111,map04113,map04114,map04120,map04914,map05166	M00389	-	-	ko00000,ko00001,ko00002,ko01009,ko03036,ko04121	-	-	-	ANAPC3,TPR_1,TPR_16,TPR_6,TPR_8
TLS2_k127_3080174_0	497964.CfE428DRAFT_2107	1.784e-127	422.0	COG0617@1|root,COG0617@2|Bacteria,46S8B@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Poly A polymerase head domain	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
TLS2_k127_3080174_1	247490.KSU1_B0531	5.166e-46	177.0	COG1262@1|root,COG1262@2|Bacteria,2J3GG@203682|Planctomycetes	203682|Planctomycetes	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TLS2_k127_308697_1	1232410.KI421425_gene1552	0.0	1271.0	COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS2_k127_308697_3	1232410.KI421425_gene1551	1.682e-69	240.0	2B4XH@1|root,32REP@2|Bacteria,1PXEZ@1224|Proteobacteria,4305C@68525|delta/epsilon subdivisions,2WVH5@28221|Deltaproteobacteria,43UUP@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_308697_2	1232410.KI421425_gene1550	6.728e-303	939.0	COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,42Z0Q@68525|delta/epsilon subdivisions,2WU0G@28221|Deltaproteobacteria,43T6R@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_308697_0	1232410.KI421425_gene1549	0.0	1427.0	COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,43CT2@68525|delta/epsilon subdivisions,2X80K@28221|Deltaproteobacteria,43TUA@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
TLS2_k127_308697_4	1232410.KI421425_gene1548	5.219e-42	160.0	COG0457@1|root,COG0457@2|Bacteria,1N1J2@1224|Proteobacteria,42ZHG@68525|delta/epsilon subdivisions,2WV2W@28221|Deltaproteobacteria,43UR6@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_310288_3	1120950.KB892751_gene6747	6.021e-19	89.0	COG3501@1|root,COG3501@2|Bacteria,2GP13@201174|Actinobacteria,4DSJK@85009|Propionibacteriales	201174|Actinobacteria	S	Phage late control gene D protein (GPD)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
TLS2_k127_310288_2	1121405.dsmv_1280	6.351e-36	139.0	2E7P5@1|root,3324R@2|Bacteria,1NEZR@1224|Proteobacteria,42VXG@68525|delta/epsilon subdivisions,2WRNQ@28221|Deltaproteobacteria,2MNUJ@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_310288_1	1121405.dsmv_1281	3.251e-42	160.0	COG3628@1|root,COG3628@2|Bacteria,1NCAC@1224|Proteobacteria,42TW2@68525|delta/epsilon subdivisions,2WQR5@28221|Deltaproteobacteria,2MNY2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Gene 25-like lysozyme	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
TLS2_k127_310288_0	1121405.dsmv_1282	1.14e-288	915.0	COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,42QGQ@68525|delta/epsilon subdivisions,2WIVM@28221|Deltaproteobacteria,2MMI8@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
TLS2_k127_3104449_3	316067.Geob_3795	8.624e-31	128.0	COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_2
TLS2_k127_3104449_4	443144.GM21_3869	8.377e-29	120.0	2E8MZ@1|root,332ZD@2|Bacteria,1P763@1224|Proteobacteria,432M3@68525|delta/epsilon subdivisions,2WXF5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3104449_2	330214.NIDE1491	4.015e-35	153.0	COG0745@1|root,COG2202@1|root,COG3829@1|root,COG4585@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4585@2|Bacteria,COG5002@2|Bacteria,3J12P@40117|Nitrospirae	40117|Nitrospirae	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA_3,PAS_9
TLS2_k127_3104449_1	584708.Apau_2199	2.131e-43	179.0	COG4191@1|root,COG4191@2|Bacteria,3TBCP@508458|Synergistetes	2|Bacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
TLS2_k127_3104449_6	1156844.KB891797_gene5598	5.204e-15	89.0	COG2203@1|root,COG2203@2|Bacteria,2IR77@201174|Actinobacteria	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2
TLS2_k127_3104449_0	187303.BN69_2708	5.529e-62	240.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TWK2@28211|Alphaproteobacteria,3700W@31993|Methylocystaceae	28211|Alphaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
TLS2_k127_3104449_5	1244869.H261_06566	4.19e-19	103.0	COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2TSY5@28211|Alphaproteobacteria,2JU4H@204441|Rhodospirillales	204441|Rhodospirillales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_9,PHY
TLS2_k127_3122216_1	161156.JQKW01000006_gene1298	3.083e-11	65.0	COG1775@1|root,COG1775@2|Bacteria,2GHFW@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
TLS2_k127_3122216_0	1134474.O59_000531	1.015e-13	76.0	2A087@1|root,30NBF@2|Bacteria,1N3MQ@1224|Proteobacteria,1SA7F@1236|Gammaproteobacteria,1FGNP@10|Cellvibrio	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3128962_2	926550.CLDAP_31560	3.212e-106	353.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_3128962_3	1340493.JNIF01000003_gene3599	1.383e-94	316.0	COG3828@1|root,COG3828@2|Bacteria,3Y2VP@57723|Acidobacteria	57723|Acidobacteria	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
TLS2_k127_3128962_4	857087.Metme_0155	7.845e-29	123.0	COG1472@1|root,COG1472@2|Bacteria,1QUPT@1224|Proteobacteria,1T20E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365
TLS2_k127_3128962_1	1128421.JAGA01000003_gene2922	1.259e-108	356.0	COG0479@1|root,COG0479@2|Bacteria,2NPY8@2323|unclassified Bacteria	2|Bacteria	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
TLS2_k127_3128962_0	111780.Sta7437_2571	1.193e-289	897.0	COG1053@1|root,COG1053@2|Bacteria,1G0NV@1117|Cyanobacteria,3VIQ2@52604|Pleurocapsales	1117|Cyanobacteria	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit, Bacillus subtilis subgroup	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_3134902_0	1267535.KB906767_gene3621	1.02e-52	203.0	COG4365@1|root,COG4365@2|Bacteria,3Y4D6@57723|Acidobacteria,2JKER@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the BshC family	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
TLS2_k127_3134902_1	555079.Toce_0773	6.027e-14	73.0	COG1555@1|root,COG1596@1|root,COG1555@2|Bacteria,COG1596@2|Bacteria,1VA3W@1239|Firmicutes,24MQF@186801|Clostridia,42GEY@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM competence protein ComEA helix-hairpin-helix	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
TLS2_k127_3137777_0	649747.HMPREF0083_01272	8.046e-94	324.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,4HDSE@91061|Bacilli,26V76@186822|Paenibacillaceae	91061|Bacilli	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_3144950_0	349741.Amuc_1659	1.173e-19	101.0	COG0582@1|root,COG0582@2|Bacteria,46T2Q@74201|Verrucomicrobia,2IV0J@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_3159816_3	100226.SCO3475	3.684e-27	115.0	COG4948@1|root,COG4948@2|Bacteria,2GT81@201174|Actinobacteria	201174|Actinobacteria	M	mandelate racemase muconate lactonizing	-	-	4.2.1.6,4.2.1.8	ko:K01684,ko:K08323	ko00040,ko00052,ko01100,ko01120,map00040,map00052,map01100,map01120	M00061,M00552	R03033,R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_3159816_1	1134413.ANNK01000002_gene2941	1.505e-42	167.0	COG1082@1|root,COG1082@2|Bacteria,1TRGF@1239|Firmicutes,4IRV2@91061|Bacilli,1ZE33@1386|Bacillus	91061|Bacilli	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_3159816_2	428125.CLOLEP_03779	3.893e-41	163.0	COG2362@1|root,COG2362@2|Bacteria,1TSUZ@1239|Firmicutes,24CY1@186801|Clostridia,3WQZA@541000|Ruminococcaceae	186801|Clostridia	E	D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
TLS2_k127_3159816_4	1123274.KB899416_gene2686	3.712e-25	118.0	COG0407@1|root,COG0407@2|Bacteria,2JAFK@203691|Spirochaetes	203691|Spirochaetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS2_k127_3159816_0	697281.Mahau_2859	2.668e-68	246.0	COG0407@1|root,COG0407@2|Bacteria	697281.Mahau_2859|-	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3159816_5	1248916.ANFY01000006_gene2004	2.521e-17	89.0	COG1802@1|root,COG1802@2|Bacteria,1P2DT@1224|Proteobacteria,2TSI4@28211|Alphaproteobacteria,2K6YI@204457|Sphingomonadales	204457|Sphingomonadales	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_3160627_1	234267.Acid_6169	1.071e-09	61.0	COG0250@1|root,COG0250@2|Bacteria,3Y8J7@57723|Acidobacteria	57723|Acidobacteria	K	Transcription termination factor nusG	-	-	-	-	-	-	-	-	-	-	-	-	NusG
TLS2_k127_3160627_0	1123371.ATXH01000003_gene1895	0.0	1093.0	COG0653@1|root,COG0653@2|Bacteria,2GGR1@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TLS2_k127_3166170_2	1173026.Glo7428_0932	3.153e-49	183.0	COG1216@1|root,COG5309@1|root,COG1216@2|Bacteria,COG5309@2|Bacteria,1G2MT@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
TLS2_k127_3166170_3	886293.Sinac_5475	3.149e-47	187.0	COG1716@1|root,COG1716@2|Bacteria,2J1M1@203682|Planctomycetes	203682|Planctomycetes	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
TLS2_k127_3166170_0	1210884.HG799463_gene10116	4.712e-95	324.0	COG1596@1|root,COG1596@2|Bacteria,2IZFX@203682|Planctomycetes	203682|Planctomycetes	M	Polysaccharide biosynthesis/export protein	-	-	-	-	-	-	-	-	-	-	-	-	Poly_export
TLS2_k127_3166170_1	1210884.HG799463_gene10202	4.919e-60	218.0	COG2204@1|root,COG2204@2|Bacteria,2IXCW@203682|Planctomycetes	203682|Planctomycetes	K	AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
TLS2_k127_317157_1	1303518.CCALI_00632	3.278e-70	244.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_317157_0	1267535.KB906767_gene4405	6.003e-112	391.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_3181770_1	1313301.AUGC01000006_gene146	2.103e-98	328.0	COG1488@1|root,COG1488@2|Bacteria,4NFQK@976|Bacteroidetes	976|Bacteroidetes	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
TLS2_k127_3181770_3	880072.Desac_0411	2.211e-53	200.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2WM7E@28221|Deltaproteobacteria,2MQQF@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	NmrA-like family	hpnA	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
TLS2_k127_3181770_2	1396141.BATP01000023_gene672	4.405e-94	313.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,DUF4241
TLS2_k127_3181770_0	767817.Desgi_0471	1.354e-101	338.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia,260DQ@186807|Peptococcaceae	186801|Clostridia	I	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_3181770_4	1111479.AXAR01000005_gene557	6.964e-08	54.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HBT0@91061|Bacilli,278VM@186823|Alicyclobacillaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS2_k127_3187904_1	234267.Acid_5340	4.925e-31	134.0	COG0577@1|root,COG0577@2|Bacteria,3Y4J3@57723|Acidobacteria	57723|Acidobacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3187904_0	234267.Acid_6574	3.647e-90	303.0	COG1131@1|root,COG1131@2|Bacteria,3Y3U0@57723|Acidobacteria	2|Bacteria	V	PFAM ABC transporter	CcmA5	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3187904_2	382464.ABSI01000011_gene2976	6.66e-31	126.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_3187975_0	656024.FsymDg_2368	8.069e-146	480.0	COG3875@1|root,COG3875@2|Bacteria,2IAM4@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
TLS2_k127_3187975_1	1144275.COCOR_01538	1.301e-75	272.0	COG0204@1|root,COG1022@1|root,COG3320@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,COG3320@2|Bacteria,1MU4D@1224|Proteobacteria,42NHQ@68525|delta/epsilon subdivisions,2WJZ5@28221|Deltaproteobacteria,2YU6Q@29|Myxococcales	28221|Deltaproteobacteria	IQ	Male sterility protein	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,NAD_binding_4,PP-binding,Sterile
TLS2_k127_3191173_2	1248917.ANFX01000032_gene831	9.785e-28	116.0	COG0659@1|root,COG0659@2|Bacteria,1MX8F@1224|Proteobacteria,2U0IJ@28211|Alphaproteobacteria,2K0EC@204457|Sphingomonadales	204457|Sphingomonadales	P	Transporter	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2,Sulfate_transp
TLS2_k127_3191173_3	1048983.EL17_12115	3.313e-22	108.0	COG0589@1|root,COG0589@2|Bacteria,4NER9@976|Bacteroidetes,47PF0@768503|Cytophagia	976|Bacteroidetes	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_3191173_0	211165.AJLN01000141_gene2471	7.669e-143	469.0	COG0520@1|root,COG0520@2|Bacteria,1G0VG@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_3191173_1	1123242.JH636435_gene2584	8.045e-45	164.0	COG1082@1|root,COG1082@2|Bacteria,2IXRD@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase-like TIM barrel	-	-	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_3222834_1	530564.Psta_1537	1.515e-83	286.0	COG0657@1|root,COG0657@2|Bacteria,2IXCK@203682|Planctomycetes	203682|Planctomycetes	I	COG0657 Esterase lipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,EF-hand_5,Peptidase_S9
TLS2_k127_3222834_0	204669.Acid345_2858	1.439e-170	569.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,3Y3GW@57723|Acidobacteria,2JHKK@204432|Acidobacteriia	2|Bacteria	I	Phosphate acyltransferases	fadD	-	2.3.1.51,6.2.1.3	ko:K00655,ko:K01897	ko00061,ko00071,ko00561,ko00564,ko01100,ko01110,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00561,map00564,map01100,map01110,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086,M00089	R01280,R02241,R09381	RC00004,RC00014,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
TLS2_k127_3222834_2	644966.Tmar_1745	3.92e-44	163.0	COG0599@1|root,COG0599@2|Bacteria,1VJJT@1239|Firmicutes	1239|Firmicutes	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_3226041_1	696281.Desru_3653	1.854e-18	95.0	COG2327@1|root,COG2327@2|Bacteria,1TPTI@1239|Firmicutes,248QN@186801|Clostridia,2603G@186807|Peptococcaceae	186801|Clostridia	S	PFAM Polysaccharide pyruvyl transferase	csaB	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,PS_pyruv_trans
TLS2_k127_3226041_0	1469607.KK073768_gene3902	4.521e-75	259.0	COG1216@1|root,COG1216@2|Bacteria,1GQEZ@1117|Cyanobacteria,1HQZG@1161|Nostocales	1117|Cyanobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_2,Glycos_transf_2
TLS2_k127_3241482_0	1380600.AUYN01000009_gene1094	2.264e-136	445.0	COG1820@1|root,COG1820@2|Bacteria,4NJ35@976|Bacteroidetes,1I1UK@117743|Flavobacteriia	976|Bacteroidetes	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS2_k127_3241482_1	483216.BACEGG_01441	3.032e-117	390.0	COG1914@1|root,COG1914@2|Bacteria,4NENE@976|Bacteroidetes,2FUNV@200643|Bacteroidia	976|Bacteroidetes	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
TLS2_k127_3241482_5	1519464.HY22_03125	0.0003976	51.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_21,TPR_6
TLS2_k127_3241482_3	1289135.A966_08089	2.171e-15	87.0	COG1729@1|root,COG4232@1|root,COG1729@2|Bacteria,COG4232@2|Bacteria	2|Bacteria	CO	protein-disulfide reductase activity	-	-	-	ko:K01999,ko:K08309	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko01000,ko01011,ko02000	3.A.1.4	GH23	-	Beta-lactamase,OmpA,SLT,TPR_6,Thioredoxin_7
TLS2_k127_3241482_2	204669.Acid345_0620	4.432e-77	270.0	COG1533@1|root,COG1533@2|Bacteria,3Y2S5@57723|Acidobacteria,2JIC8@204432|Acidobacteriia	204432|Acidobacteriia	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_3241482_4	1131269.AQVV01000002_gene1204	7.293e-10	61.0	COG1200@1|root,COG1200@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
TLS2_k127_3245525_1	203119.Cthe_2586	9.998e-98	327.0	COG2159@1|root,COG2159@2|Bacteria,1TRU0@1239|Firmicutes,248VZ@186801|Clostridia,3WHH4@541000|Ruminococcaceae	186801|Clostridia	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_3245525_4	324602.Caur_3390	1.986e-48	178.0	COG2947@1|root,COG2947@2|Bacteria,2G93S@200795|Chloroflexi,375T3@32061|Chloroflexia	32061|Chloroflexia	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
TLS2_k127_3245525_5	428126.CLOSPI_01287	4.753e-39	155.0	COG4464@1|root,COG4464@2|Bacteria,1TQ1T@1239|Firmicutes,3VR4Y@526524|Erysipelotrichia	526524|Erysipelotrichia	GM	Capsular polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3245525_0	204669.Acid345_4631	3.015e-101	344.0	COG0577@1|root,COG0577@2|Bacteria,3Y3X9@57723|Acidobacteria,2JHKJ@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_3245525_2	204669.Acid345_4630	2.976e-90	312.0	COG0577@1|root,COG0577@2|Bacteria,3Y2IG@57723|Acidobacteria,2JHUY@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_3245525_3	204669.Acid345_3531	2.715e-83	289.0	COG0845@1|root,COG0845@2|Bacteria,3Y2F6@57723|Acidobacteria,2JI56@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
TLS2_k127_325129_1	1121430.JMLG01000023_gene1442	1.264e-90	308.0	COG0471@1|root,COG0471@2|Bacteria,1TSP2@1239|Firmicutes,24DU3@186801|Clostridia,26769@186807|Peptococcaceae	186801|Clostridia	P	Similarity to COG0471 Di- and tricarboxylate transporters(Evalue	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
TLS2_k127_325129_0	1123274.KB899460_gene3986	8.167e-105	353.0	COG2610@1|root,COG2610@2|Bacteria,2J5W9@203691|Spirochaetes	203691|Spirochaetes	EG	Gluconate	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
TLS2_k127_3255551_3	1380390.JIAT01000009_gene840	1.335e-11	64.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria,4CQ49@84995|Rubrobacteria	201174|Actinobacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_3255551_0	1454007.JAUG01000019_gene1150	4.222e-219	696.0	COG1653@1|root,COG1653@2|Bacteria,4NG6U@976|Bacteroidetes,1IV8H@117747|Sphingobacteriia	976|Bacteroidetes	G	Protein of unknown function (DUF1565)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF1565
TLS2_k127_3255551_1	1122917.KB899660_gene1492	3.127e-82	292.0	COG4948@1|root,COG4948@2|Bacteria,1TS0S@1239|Firmicutes,4HC1G@91061|Bacilli,26VB1@186822|Paenibacillaceae	91061|Bacilli	M	mandelate racemase muconate lactonizing	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_3255551_2	530564.Psta_0403	9.227e-14	81.0	COG0412@1|root,COG1073@1|root,COG0412@2|Bacteria,COG1073@2|Bacteria,2IYEI@203682|Planctomycetes	203682|Planctomycetes	Q	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS2_k127_3259289_6	525904.Tter_2228	4.635e-67	235.0	COG2017@1|root,COG2017@2|Bacteria,2NQQX@2323|unclassified Bacteria	2|Bacteria	G	Domain of unknown function (DUF4432)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4432
TLS2_k127_3259289_1	1267535.KB906767_gene3033	4.187e-141	457.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
TLS2_k127_3259289_5	435908.IDSA_11395	9.555e-87	304.0	COG0845@1|root,COG0845@2|Bacteria,1NQDN@1224|Proteobacteria,1RRFE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TLS2_k127_3259289_3	493475.GARC_3473	3.518e-96	320.0	COG1136@1|root,COG1136@2|Bacteria,1NHCD@1224|Proteobacteria,1RNIX@1236|Gammaproteobacteria,464FN@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3259289_2	1128912.GMES_0450	2.763e-108	366.0	COG0577@1|root,COG0577@2|Bacteria,1QSVW@1224|Proteobacteria,1RPBM@1236|Gammaproteobacteria,465M6@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_3259289_7	1129794.C427_2763	2.811e-61	227.0	COG0577@1|root,COG0577@2|Bacteria,1MXFC@1224|Proteobacteria,1RQX0@1236|Gammaproteobacteria,46698@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_3259289_0	448385.sce8837	1.618e-151	492.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YU6E@29|Myxococcales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_3259289_4	1234364.AMSF01000095_gene2542	2.571e-92	319.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1X41T@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	styS	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_8
TLS2_k127_3269824_2	1304880.JAGB01000002_gene2198	2.055e-53	201.0	COG1874@1|root,COG1874@2|Bacteria,1TT9J@1239|Firmicutes,24CY9@186801|Clostridia	186801|Clostridia	G	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
TLS2_k127_3269824_0	1305737.JAFX01000001_gene1812	3.871e-63	248.0	2CHVP@1|root,2Z866@2|Bacteria,4NJWZ@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3269824_1	1033743.CAES01000046_gene265	9.258e-61	222.0	COG0673@1|root,COG0673@2|Bacteria,1UUTP@1239|Firmicutes,4HYQG@91061|Bacilli	91061|Bacilli	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_3270964_1	1148.1653044	7.058e-56	208.0	COG3292@1|root,COG3292@2|Bacteria,1G2WX@1117|Cyanobacteria	1117|Cyanobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	Reg_prop
TLS2_k127_3270964_2	1407650.BAUB01000015_gene2281	1.679e-54	198.0	COG3842@1|root,COG3842@2|Bacteria,1G14G@1117|Cyanobacteria,1GZBE@1129|Synechococcus	1117|Cyanobacteria	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
TLS2_k127_3270964_0	1407650.BAUB01000015_gene2280	2.805e-88	312.0	COG1178@1|root,COG1178@2|Bacteria,1GCQ2@1117|Cyanobacteria	1117|Cyanobacteria	P	ABC-type Fe3 transport system permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	-
TLS2_k127_3284324_4	1038859.AXAU01000002_gene255	1.659e-14	74.0	COG1680@1|root,COG1680@2|Bacteria,1MY4Y@1224|Proteobacteria,2TYCG@28211|Alphaproteobacteria,3JTS9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_3284324_2	1267533.KB906740_gene246	2.111e-24	108.0	COG0789@1|root,COG0789@2|Bacteria,3Y56I@57723|Acidobacteria,2JJNQ@204432|Acidobacteriia	204432|Acidobacteriia	K	Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_3284324_3	1122970.AUHC01000008_gene96	5.324e-15	78.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2UCDG@28211|Alphaproteobacteria,2K62D@204457|Sphingomonadales	204457|Sphingomonadales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_3284324_0	1235279.C772_00434	5.167e-120	399.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4HAJ6@91061|Bacilli,26CXK@186818|Planococcaceae	91061|Bacilli	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
TLS2_k127_3284324_1	760568.Desku_0259	1.819e-52	192.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,2606G@186807|Peptococcaceae	186801|Clostridia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TLS2_k127_329851_2	246197.MXAN_4249	5.518e-95	323.0	COG2823@1|root,COG5637@1|root,COG2823@2|Bacteria,COG5637@2|Bacteria,1RI3F@1224|Proteobacteria,437A8@68525|delta/epsilon subdivisions,2X2EK@28221|Deltaproteobacteria,2YVIY@29|Myxococcales	28221|Deltaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TLS2_k127_329851_8	926566.Terro_2880	7.294e-08	64.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,3Y8DM@57723|Acidobacteria	57723|Acidobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_329851_1	489825.LYNGBM3L_38110	3.151e-95	323.0	COG1216@1|root,COG1216@2|Bacteria,1GQEZ@1117|Cyanobacteria,1HI6Y@1150|Oscillatoriales	1117|Cyanobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_2,Glycos_transf_2,Methyltransf_23
TLS2_k127_329851_4	1337936.IJ00_06620	3.733e-70	250.0	COG0726@1|root,COG0726@2|Bacteria,1G0GG@1117|Cyanobacteria,1HRNI@1161|Nostocales	1117|Cyanobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_329851_3	1173022.Cri9333_2778	2.824e-80	277.0	COG0500@1|root,COG2226@2|Bacteria,1GR91@1117|Cyanobacteria	1117|Cyanobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_329851_7	324602.Caur_1468	4.078e-19	99.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS2_k127_329851_6	357808.RoseRS_2673	9.966e-21	100.0	COG3467@1|root,COG3467@2|Bacteria,2G729@200795|Chloroflexi,377IP@32061|Chloroflexia	32061|Chloroflexia	S	PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
TLS2_k127_329851_5	234267.Acid_5754	3.459e-31	126.0	COG3324@1|root,COG3324@2|Bacteria,3Y8A9@57723|Acidobacteria	57723|Acidobacteria	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_329851_0	344747.PM8797T_18384	6.438e-121	401.0	COG0673@1|root,COG0673@2|Bacteria,2IWRC@203682|Planctomycetes	203682|Planctomycetes	S	COGs COG0673 dehydrogenase and related protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_3305435_1	457412.RSAG_02822	2.078e-41	169.0	COG2159@1|root,COG2159@2|Bacteria,1UZI6@1239|Firmicutes,24EHD@186801|Clostridia,3WKR9@541000|Ruminococcaceae	186801|Clostridia	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_3305435_0	234267.Acid_0387	3.554e-91	312.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
TLS2_k127_3311267_2	640511.BC1002_3779	1.665e-45	167.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VRN8@28216|Betaproteobacteria,1K4S6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_3311267_1	76114.ebA4612	7.645e-79	274.0	COG0697@1|root,COG0697@2|Bacteria,1NEYM@1224|Proteobacteria,2VPAG@28216|Betaproteobacteria,2KW5W@206389|Rhodocyclales	206389|Rhodocyclales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_3311267_0	706587.Desti_4248	7.373e-181	571.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PCA@68525|delta/epsilon subdivisions,2WM39@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_3311267_3	1173026.Glo7428_2958	3.696e-19	92.0	2DM1K@1|root,31BCJ@2|Bacteria,1G6WG@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3328185_2	370438.PTH_2734	5.837e-40	162.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,260S2@186807|Peptococcaceae	186801|Clostridia	GK	pfam rok	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10220	ROK
TLS2_k127_3328185_1	234267.Acid_2237	9.066e-57	205.0	COG0279@1|root,COG0279@2|Bacteria,3Y7D7@57723|Acidobacteria	57723|Acidobacteria	G	SIS domain	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
TLS2_k127_3328185_0	177437.HRM2_09760	5.166e-110	367.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WJM0@28221|Deltaproteobacteria,2MJ63@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13,2.3.3.14	ko:K01649,ko:K02594	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R00271,R01213	RC00004,RC00067,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS2_k127_3328185_3	1267535.KB906767_gene3948	7.41e-12	74.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_3348449_1	760568.Desku_2853	6.006e-240	761.0	COG1449@1|root,COG1449@2|Bacteria,1UVAN@1239|Firmicutes,24B0Y@186801|Clostridia,260ZW@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
TLS2_k127_3348449_0	1304880.JAGB01000003_gene1291	2.163e-276	863.0	COG1274@1|root,COG1274@2|Bacteria,1TQED@1239|Firmicutes,249NP@186801|Clostridia	186801|Clostridia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
TLS2_k127_3348741_8	204669.Acid345_1592	8.932e-08	59.0	COG3063@1|root,COG3063@2|Bacteria,3Y5SX@57723|Acidobacteria	57723|Acidobacteria	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
TLS2_k127_3348741_6	1121920.AUAU01000002_gene2138	9.019e-29	117.0	COG1923@1|root,COG1923@2|Bacteria,3Y5JI@57723|Acidobacteria	57723|Acidobacteria	S	Hfq protein	-	-	-	-	-	-	-	-	-	-	-	-	Hfq
TLS2_k127_3348741_9	7165.AGAP009578-PA	7.165e-06	57.0	COG3177@1|root,KOG3824@2759|Eukaryota,38B91@33154|Opisthokonta,3BDIM@33208|Metazoa,3CV6D@33213|Bilateria,41TM7@6656|Arthropoda,3SGRH@50557|Insecta,44YGC@7147|Diptera,45EEP@7148|Nematocera	33208|Metazoa	S	Adenosine monophosphate-protein transferase FICD homolog	FICD	GO:0000166,GO:0003008,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0006464,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0006950,GO:0006952,GO:0007600,GO:0007601,GO:0007610,GO:0007632,GO:0008081,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009416,GO:0009581,GO:0009582,GO:0009583,GO:0009584,GO:0009605,GO:0009607,GO:0009617,GO:0009628,GO:0009966,GO:0009987,GO:0010646,GO:0012505,GO:0015696,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0017076,GO:0018117,GO:0018175,GO:0019538,GO:0023051,GO:0030176,GO:0030544,GO:0030554,GO:0031072,GO:0031224,GO:0031227,GO:0031967,GO:0031975,GO:0031984,GO:0032501,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034260,GO:0034976,GO:0035639,GO:0036094,GO:0036211,GO:0042175,GO:0042578,GO:0042742,GO:0042802,GO:0042803,GO:0043086,GO:0043087,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044601,GO:0044602,GO:0044603,GO:0045117,GO:0046983,GO:0048519,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0050829,GO:0050877,GO:0050896,GO:0050906,GO:0050908,GO:0050953,GO:0050962,GO:0051087,GO:0051179,GO:0051234,GO:0051336,GO:0051346,GO:0051606,GO:0051608,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0065009,GO:0070566,GO:0070733,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0080134,GO:0080135,GO:0097159,GO:0097367,GO:0098542,GO:0098827,GO:0140096,GO:1900101,GO:1901265,GO:1901363,GO:1901564,GO:1903894,GO:1905897	-	-	-	-	-	-	-	-	-	-	Fic
TLS2_k127_3348741_7	331678.Cphamn1_2098	2.317e-23	107.0	COG5523@1|root,COG5523@2|Bacteria,1FEN5@1090|Chlorobi	1090|Chlorobi	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3348741_1	234267.Acid_1288	2.227e-115	389.0	COG0260@1|root,COG0260@2|Bacteria,3Y33T@57723|Acidobacteria	57723|Acidobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS2_k127_3348741_4	1158601.I585_01229	2.347e-50	184.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,4HGZX@91061|Bacilli,4AZQS@81852|Enterococcaceae	91061|Bacilli	J	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070930,GO:0071704,GO:1901564	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
TLS2_k127_3348741_3	1121346.KB899817_gene3225	1.088e-77	269.0	COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,4HBXF@91061|Bacilli,26SEN@186822|Paenibacillaceae	91061|Bacilli	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
TLS2_k127_3348741_0	324057.Pjdr2_4988	4.341e-142	458.0	COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,4HA3Y@91061|Bacilli,26RIV@186822|Paenibacillaceae	91061|Bacilli	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	spsJ	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_3348741_2	330214.NIDE3016	1.722e-102	338.0	COG1209@1|root,COG1209@2|Bacteria,3J0KX@40117|Nitrospirae	40117|Nitrospirae	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_3348741_5	1121428.DESHY_10111___1	8.555e-31	126.0	COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia,261PX@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_334890_4	926554.KI912670_gene1977	1.012e-70	244.0	COG2268@1|root,COG2268@2|Bacteria	2|Bacteria	T	Band 7 protein	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
TLS2_k127_334890_10	1242864.D187_004177	2.863e-09	65.0	2AS5D@1|root,32BXX@2|Bacteria,1QADV@1224|Proteobacteria,4350N@68525|delta/epsilon subdivisions,2X93Y@28221|Deltaproteobacteria,2Z1S2@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_334890_8	1205908.AKXW01000045_gene3651	1.348e-17	92.0	COG1842@1|root,COG1842@2|Bacteria,1NC7S@1224|Proteobacteria,1RS0G@1236|Gammaproteobacteria,1XUJH@135623|Vibrionales	135623|Vibrionales	KT	COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription	pspA	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
TLS2_k127_334890_2	313628.LNTAR_02502	2.625e-98	331.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	zraR	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
TLS2_k127_334890_9	1121413.JMKT01000009_gene1824	2.022e-16	88.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,42P9R@68525|delta/epsilon subdivisions,2WJAD@28221|Deltaproteobacteria,2MG9B@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_334890_6	65393.PCC7424_4056	9.105e-33	138.0	29Z9K@1|root,30M7T@2|Bacteria,1GM3Q@1117|Cyanobacteria,3KJ43@43988|Cyanothece	1117|Cyanobacteria	S	Protein of unknown function (DUF3592)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3592
TLS2_k127_334890_7	926550.CLDAP_36710	1.313e-30	124.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	arsR	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
TLS2_k127_334890_5	926550.CLDAP_37010	9.024e-68	239.0	COG0500@1|root,COG2226@2|Bacteria,2G6GD@200795|Chloroflexi	200795|Chloroflexi	Q	Methyltransferase type 11	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
TLS2_k127_334890_3	1449063.JMLS01000004_gene2483	2.13e-86	310.0	28M5E@1|root,2ZAJ7@2|Bacteria,1W635@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_334890_12	1239962.C943_04416	7.992e-07	62.0	COG3386@1|root,COG3386@2|Bacteria,4NF4A@976|Bacteroidetes,47JC9@768503|Cytophagia	976|Bacteroidetes	G	PFAM SMP-30 Gluconolaconase	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pectate_lyase_3,SGL
TLS2_k127_334890_1	616991.JPOO01000003_gene1249	4.276e-149	486.0	COG0673@1|root,COG0673@2|Bacteria,4NF96@976|Bacteroidetes,1HZMA@117743|Flavobacteriia,23GJG@178469|Arenibacter	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_334890_0	696281.Desru_0987	1.013e-199	637.0	COG4147@1|root,COG4147@2|Bacteria,1V2SK@1239|Firmicutes,25DGS@186801|Clostridia,264G7@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_334890_11	477974.Daud_1571	1.812e-07	54.0	2C2F3@1|root,33J8S@2|Bacteria,1W120@1239|Firmicutes,254DI@186801|Clostridia,265TH@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3355173_1	234267.Acid_5457	0.0	1217.0	COG0085@1|root,COG0085@2|Bacteria,3Y36G@57723|Acidobacteria	57723|Acidobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
TLS2_k127_3355173_0	671143.DAMO_0533	0.0	1244.0	COG0086@1|root,COG0086@2|Bacteria,2NNPR@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
TLS2_k127_3362057_2	194867.ALBQ01000039_gene3098	3.985e-66	233.0	COG1874@1|root,COG1874@2|Bacteria,1P0Y5@1224|Proteobacteria,2TUD3@28211|Alphaproteobacteria,2K27P@204457|Sphingomonadales	204457|Sphingomonadales	G	Glycosyl hydrolases family 35	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_35,Glyco_hydro_42
TLS2_k127_3362057_3	1266914.ATUK01000010_gene1217	1.194e-55	204.0	COG1943@1|root,COG1943@2|Bacteria,1RBFM@1224|Proteobacteria,1SPM8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
TLS2_k127_3362057_0	886293.Sinac_6626	1.757e-198	628.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K03086,ko:K06867	-	-	-	-	ko00000,ko03021	-	-	-	Ank,Ank_2,Ank_4,Ank_5
TLS2_k127_3362057_1	316067.Geob_2599	2.908e-69	250.0	COG2982@1|root,COG2982@2|Bacteria,1PJZH@1224|Proteobacteria,42XG1@68525|delta/epsilon subdivisions,2WTDH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
TLS2_k127_336731_0	330214.NIDE0889	2.185e-221	698.0	COG1596@1|root,COG1596@2|Bacteria	2|Bacteria	M	polysaccharide export	kpsD	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Caps_synth_GfcC,Poly_export,SLBB
TLS2_k127_3367645_3	246197.MXAN_5109	1.711e-55	208.0	COG0132@1|root,COG0132@2|Bacteria,1MYAE@1224|Proteobacteria	1224|Proteobacteria	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611
TLS2_k127_3367645_2	1236689.MMALV_06140	2.373e-76	268.0	COG0002@1|root,arCOG00495@2157|Archaea,2XTC1@28890|Euryarchaeota	28890|Euryarchaeota	E	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily	argC	-	1.2.1.38	ko:K00145,ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R03443,R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_3367645_1	309807.SRU_2217	1.42e-94	325.0	COG4992@1|root,COG4992@2|Bacteria,4NE0Z@976|Bacteroidetes,1FJWU@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_3367645_4	903818.KI912269_gene306	4.424e-42	166.0	COG0548@1|root,COG0548@2|Bacteria,3Y2IF@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
TLS2_k127_3367645_0	1121468.AUBR01000017_gene2371	3.775e-180	576.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,42EXF@68295|Thermoanaerobacterales	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_3367645_6	1499685.CCFJ01000017_gene1568	1.815e-12	71.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,4HNNA@91061|Bacilli,1ZH54@1386|Bacillus	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
TLS2_k127_3367645_5	235909.GK1267	2.778e-24	106.0	COG0196@1|root,COG0196@2|Bacteria,1TPKS@1239|Firmicutes,4H9KE@91061|Bacilli,1WES7@129337|Geobacillus	91061|Bacilli	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS06310	FAD_syn,Flavokinase
TLS2_k127_3372238_2	234267.Acid_6939	3.194e-55	202.0	COG1629@1|root,COG4771@2|Bacteria,3Y2MF@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_3372238_0	909663.KI867150_gene1869	9.166e-209	664.0	COG0493@1|root,COG0493@2|Bacteria,1NT36@1224|Proteobacteria,42ZEC@68525|delta/epsilon subdivisions	1224|Proteobacteria	E	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
TLS2_k127_3372238_4	909663.KI867150_gene1869	5.083e-33	132.0	COG0493@1|root,COG0493@2|Bacteria,1NT36@1224|Proteobacteria,42ZEC@68525|delta/epsilon subdivisions	1224|Proteobacteria	E	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
TLS2_k127_3372238_1	693661.Arcve_1569	9.334e-102	343.0	COG1941@1|root,arCOG02472@2157|Archaea,2XV6A@28890|Euryarchaeota,24707@183980|Archaeoglobi	183980|Archaeoglobi	C	Coenzyme F420-reducing hydrogenase, gamma subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
TLS2_k127_3372238_3	880073.Calab_3043	1.497e-39	151.0	COG3259@1|root,COG3259@2|Bacteria,2NQGS@2323|unclassified Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
TLS2_k127_3373803_3	575540.Isop_0365	1.258e-83	289.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,2IZ46@203682|Planctomycetes	203682|Planctomycetes	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa
TLS2_k127_3373803_0	575540.Isop_0366	1.887e-160	520.0	COG0651@1|root,COG0651@2|Bacteria,2IYC5@203682|Planctomycetes	203682|Planctomycetes	CP	Proton-conducting membrane transporter	-	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
TLS2_k127_3373803_4	404589.Anae109_3783	3.189e-50	190.0	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,42NDW@68525|delta/epsilon subdivisions,2WMF0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	hydrogenase 4 membrane	ehrC	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q2
TLS2_k127_3373803_2	404589.Anae109_3782	6.189e-91	308.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,42NHI@68525|delta/epsilon subdivisions,2WJ3D@28221|Deltaproteobacteria,2Z0BP@29|Myxococcales	28221|Deltaproteobacteria	C	NADH dehydrogenase	ehrB	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0374,iAF987.Gmet_2600	NADHdh
TLS2_k127_3373803_1	1232410.KI421427_gene1299	3.334e-159	524.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,42NFV@68525|delta/epsilon subdivisions,2WJZ0@28221|Deltaproteobacteria,43T2H@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM NADH Ubiquinone plastoquinone (complex I)	ehrA-2	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
TLS2_k127_3383545_3	1906.SFRA_14330	9.846e-28	126.0	COG5297@1|root,COG5297@2|Bacteria,2GMQN@201174|Actinobacteria	201174|Actinobacteria	G	PFAM glycoside hydrolase, family 9	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CelD_N,Glyco_hydro_9
TLS2_k127_3383545_1	525897.Dbac_2454	1.634e-120	405.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria,2M8CP@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS2_k127_3383545_0	1492738.FEM21_11970	1.458e-185	591.0	COG0477@1|root,COG2814@2|Bacteria,4NE09@976|Bacteroidetes,1HY74@117743|Flavobacteriia,2NTY0@237|Flavobacterium	976|Bacteroidetes	U	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	xylE	-	-	ko:K02100,ko:K03444,ko:K08138	-	-	-	-	ko00000,ko02000	2.A.1.1,2.A.1.1.2,2.A.1.1.3	-	-	Sugar_tr
TLS2_k127_3383545_2	1123242.JH636434_gene4153	6.502e-77	261.0	COG4409@1|root,COG4409@2|Bacteria,2J53Z@203682|Planctomycetes	203682|Planctomycetes	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_3383931_0	595460.RRSWK_05871	1.645e-142	476.0	COG3828@1|root,COG3828@2|Bacteria,2IX0E@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,ThuA
TLS2_k127_3383931_1	981369.JQMJ01000002_gene40	1.145e-45	175.0	COG2273@1|root,COG2273@2|Bacteria	2|Bacteria	G	xyloglucan:xyloglucosyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16,RicinB_lectin_2
TLS2_k127_3383931_2	1267534.KB906758_gene2473	5.628e-31	128.0	COG0265@1|root,COG0265@2|Bacteria,3Y7Q3@57723|Acidobacteria,2JMRR@204432|Acidobacteriia	204432|Acidobacteriia	O	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
TLS2_k127_3383931_3	314278.NB231_16453	2.287e-16	80.0	COG1848@1|root,COG1848@2|Bacteria,1RK9K@1224|Proteobacteria,1SBYF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_338418_4	909663.KI867149_gene3418	3.072e-18	87.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,42NI7@68525|delta/epsilon subdivisions,2WNPX@28221|Deltaproteobacteria,2MQHH@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.21,5.4.99.22	ko:K06178,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_338418_3	768670.Calni_1659	4.656e-46	181.0	COG0307@1|root,COG0307@2|Bacteria,2GFHM@200930|Deferribacteres	200930|Deferribacteres	H	Lumazine binding domain	-	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
TLS2_k127_338418_0	269799.Gmet_1626	1.075e-128	422.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,43U14@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
TLS2_k127_338418_2	204669.Acid345_3561	4.714e-69	246.0	COG2304@1|root,COG2304@2|Bacteria,3Y3QQ@57723|Acidobacteria,2JHV1@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
TLS2_k127_338418_1	431943.CKL_2501	9.441e-80	275.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,36DE3@31979|Clostridiaceae	186801|Clostridia	S	TIGRFAM TIGR00268 family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,NAD_synthase,QueC
TLS2_k127_3385579_2	1232410.KI421421_gene3287	3.37e-22	101.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42MSS@68525|delta/epsilon subdivisions,2WIN2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EQ	Hydantoinaseoxoprolinase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638,Hydant_A_N,Hydantoinase_A
TLS2_k127_3385579_1	768710.DesyoDRAFT_3591	3.601e-55	202.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,2659T@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM methyltransferase cognate corrinoid proteins, Methanosarcina family	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
TLS2_k127_3385579_0	589865.DaAHT2_2487	3.475e-104	355.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,42Q8R@68525|delta/epsilon subdivisions,2WMDK@28221|Deltaproteobacteria,2MJEG@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
TLS2_k127_339114_4	1415780.JPOG01000001_gene158	8.447e-05	54.0	COG2823@1|root,COG2823@2|Bacteria,1N0SU@1224|Proteobacteria,1S926@1236|Gammaproteobacteria,1X95P@135614|Xanthomonadales	135614|Xanthomonadales	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS2_k127_339114_0	1232410.KI421413_gene952	6.161e-293	921.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,4378Y@68525|delta/epsilon subdivisions,2X2C1@28221|Deltaproteobacteria,43UD2@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	ATP dependent DNA ligase C terminal region	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS2_k127_339114_1	1254432.SCE1572_15910	2.323e-74	267.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YV5B@29|Myxococcales	28221|Deltaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
TLS2_k127_339114_3	2325.TKV_c05360	1.327e-23	106.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia,42G5T@68295|Thermoanaerobacterales	186801|Clostridia	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
TLS2_k127_3398542_2	1191523.MROS_1493	1.492e-64	238.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
TLS2_k127_3398542_0	204669.Acid345_0751	1.418e-159	515.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria,2JICQ@204432|Acidobacteriia	204432|Acidobacteriia	T	PFAM Response regulator receiver domain	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_3398542_1	1128421.JAGA01000003_gene3166	1.353e-84	292.0	COG3643@1|root,COG3643@2|Bacteria,2NS5U@2323|unclassified Bacteria	2|Bacteria	E	Formiminotransferase domain, N-terminal subdomain	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K01746,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
TLS2_k127_3398542_4	562970.Btus_2507	1.453e-46	174.0	COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,4HFNY@91061|Bacilli,279PR@186823|Alicyclobacillaceae	91061|Bacilli	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	cspR	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
TLS2_k127_3398542_3	314285.KT71_04350	5.939e-57	209.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1SKMW@1236|Gammaproteobacteria,1J9PK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_3399518_2	428125.CLOLEP_03295	1.702e-55	202.0	COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia,3WG7D@541000|Ruminococcaceae	186801|Clostridia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
TLS2_k127_3399518_1	1340493.JNIF01000003_gene3709	1.141e-73	255.0	COG0681@1|root,COG0681@2|Bacteria,3Y40D@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS2_k127_3399518_3	439235.Dalk_2504	1.677e-29	128.0	COG0500@1|root,COG2835@1|root,COG2226@2|Bacteria,COG2835@2|Bacteria,1NWX3@1224|Proteobacteria,42URB@68525|delta/epsilon subdivisions,2WQ85@28221|Deltaproteobacteria,2MKYQ@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_3399518_0	1382359.JIAL01000001_gene437	1.735e-96	320.0	COG0556@1|root,COG0556@2|Bacteria,3Y31K@57723|Acidobacteria,2JHY9@204432|Acidobacteriia	204432|Acidobacteriia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
TLS2_k127_3408430_0	656024.FsymDg_2095	6.335e-119	396.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4ESWQ@85013|Frankiales	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_3408430_2	439292.Bsel_0412	2.175e-51	202.0	COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,4HDE3@91061|Bacilli	91061|Bacilli	GK	ROK family	xylR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK
TLS2_k127_3408430_1	234267.Acid_6247	2.367e-71	256.0	COG0673@1|root,COG0673@2|Bacteria,3Y39X@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_3408430_3	1535422.ND16A_1769	6.682e-28	120.0	2DMN1@1|root,32SKS@2|Bacteria,1RCAE@1224|Proteobacteria,1S2KJ@1236|Gammaproteobacteria,2Q7I5@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Carbohydrate family 9 binding domain-like	VY92_09500	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
TLS2_k127_341280_9	1047013.AQSP01000091_gene648	2.665e-29	119.0	COG0020@1|root,COG0020@2|Bacteria,2NP9M@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS2_k127_341280_6	903814.ELI_4001	1.091e-60	219.0	COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia,25US1@186806|Eubacteriaceae	186801|Clostridia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
TLS2_k127_341280_1	880073.Calab_2588	1.033e-100	333.0	COG0217@1|root,COG0217@2|Bacteria,2NNSI@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TLS2_k127_341280_7	394503.Ccel_1346	1.549e-43	164.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,36J15@31979|Clostridiaceae	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
TLS2_k127_341280_5	204669.Acid345_3359	2.469e-68	241.0	COG1355@1|root,COG1355@2|Bacteria,3Y5Z0@57723|Acidobacteria,2JNSZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
TLS2_k127_341280_8	1121405.dsmv_1158	5.904e-37	147.0	COG0652@1|root,COG0652@2|Bacteria,1R4KH@1224|Proteobacteria,42R08@68525|delta/epsilon subdivisions,2WWSG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
TLS2_k127_341280_3	234267.Acid_2976	1.151e-76	267.0	COG0667@1|root,COG0667@2|Bacteria,3Y3TE@57723|Acidobacteria	57723|Acidobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_341280_2	667014.Thein_0868	3.072e-93	315.0	COG1899@1|root,COG1899@2|Bacteria,2GIEP@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_341280_0	1267535.KB906767_gene4338	0.0	1100.0	COG0178@1|root,COG0178@2|Bacteria,3Y3G9@57723|Acidobacteria,2JI80@204432|Acidobacteriia	204432|Acidobacteriia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_341280_4	926550.CLDAP_25590	4.414e-69	257.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	BatA,CARDB,DUF3367,DUF4091,DUF4159
TLS2_k127_3420316_10	1541065.JRFE01000022_gene4107	0.0007364	48.0	COG0569@1|root,COG0569@2|Bacteria,1G0ZA@1117|Cyanobacteria,3VJ0G@52604|Pleurocapsales	1117|Cyanobacteria	P	PFAM TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS2_k127_3420316_2	243231.GSU1203	9.695e-152	494.0	COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,42MWU@68525|delta/epsilon subdivisions,2WKCW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger,TrkA_C
TLS2_k127_3420316_8	880072.Desac_1169	7.397e-49	183.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42SHQ@68525|delta/epsilon subdivisions,2WP9W@28221|Deltaproteobacteria,2MS1C@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Ferric uptake regulator family	-	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_3420316_0	644282.Deba_0799	4.058e-276	855.0	COG0753@1|root,COG0753@2|Bacteria,1MUXZ@1224|Proteobacteria,42MIN@68525|delta/epsilon subdivisions,2WJC5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	serves to protect cells from the toxic effects of hydrogen peroxide	katA	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
TLS2_k127_3420316_5	382464.ABSI01000020_gene317	9.093e-66	235.0	COG1237@1|root,COG1237@2|Bacteria	2|Bacteria	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
TLS2_k127_3420316_7	1042877.GQS_00445	3.712e-50	183.0	COG1720@1|root,arCOG00761@2157|Archaea,2XY3D@28890|Euryarchaeota,2440R@183968|Thermococci	183968|Thermococci	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
TLS2_k127_3420316_9	324925.Ppha_0987	0.0001409	46.0	COG2318@1|root,COG2318@2|Bacteria,1FF75@1090|Chlorobi	1090|Chlorobi	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
TLS2_k127_3420316_1	243090.RB7999	4.163e-153	492.0	COG0329@1|root,COG0329@2|Bacteria,2IXEF@203682|Planctomycetes	203682|Planctomycetes	EM	Belongs to the DapA family	-	-	-	-	-	-	-	-	-	-	-	-	DHDPS
TLS2_k127_3420316_3	861299.J421_5594	1.791e-108	366.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_3420316_6	1288963.ADIS_3437	1.48e-52	196.0	COG0454@1|root,COG0456@2|Bacteria,4NT7Q@976|Bacteroidetes,47VTT@768503|Cytophagia	976|Bacteroidetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
TLS2_k127_3420316_4	234267.Acid_0711	2.165e-98	329.0	COG0451@1|root,COG0451@2|Bacteria,3Y6G4@57723|Acidobacteria	57723|Acidobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_3430792_2	1125863.JAFN01000001_gene1760	8.182e-29	120.0	COG3581@1|root,COG3581@2|Bacteria,1PDHS@1224|Proteobacteria,43DP1@68525|delta/epsilon subdivisions	1224|Proteobacteria	I	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
TLS2_k127_3430792_0	1125863.JAFN01000001_gene1761	1.855e-301	955.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	ATPase BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
TLS2_k127_3430792_1	518766.Rmar_2303	1.309e-195	619.0	COG1904@1|root,COG1904@2|Bacteria,4NFHS@976|Bacteroidetes	976|Bacteroidetes	G	glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
TLS2_k127_3435529_0	1121459.AQXE01000018_gene2080	1.82e-76	269.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42MAP@68525|delta/epsilon subdivisions,2X85M@28221|Deltaproteobacteria,2M8ZC@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
TLS2_k127_3435529_2	641491.DND132_2126	1.154e-08	66.0	COG0589@1|root,COG0589@2|Bacteria,1NUP4@1224|Proteobacteria,435RE@68525|delta/epsilon subdivisions,2X061@28221|Deltaproteobacteria,2MAS3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response to stress	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_3435529_1	1210884.HG799473_gene15023	4.602e-71	255.0	COG0823@1|root,COG1506@1|root,COG2866@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,COG2866@2|Bacteria,2J1EY@203682|Planctomycetes	203682|Planctomycetes	E	Zinc carboxypeptidase	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_M14,Peptidase_S9
TLS2_k127_3476979_0	234267.Acid_3496	1.151e-264	824.0	COG0457@1|root,COG0457@2|Bacteria,3Y3WM@57723|Acidobacteria	57723|Acidobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS2_k127_3477973_9	1157490.EL26_08970	6.586e-05	51.0	2DD6X@1|root,2ZGTW@2|Bacteria,1W4U1@1239|Firmicutes,4I1VV@91061|Bacilli	91061|Bacilli	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
TLS2_k127_3477973_0	639030.JHVA01000001_gene3551	8.105e-140	457.0	COG0621@1|root,COG0621@2|Bacteria,3Y362@57723|Acidobacteria,2JIYW@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
TLS2_k127_3477973_7	1033802.SSPSH_000279	2.877e-12	68.0	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,1SC7M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	GO:0003674,GO:0004857,GO:0005488,GO:0008150,GO:0008270,GO:0008657,GO:0010911,GO:0030234,GO:0032780,GO:0042030,GO:0043086,GO:0043167,GO:0043169,GO:0043462,GO:0044092,GO:0046872,GO:0046914,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0098772,GO:2000371,GO:2000372	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
TLS2_k127_3477973_5	118005.AWNK01000010_gene383	2.895e-25	113.0	COG1267@1|root,COG1267@2|Bacteria	2|Bacteria	I	phosphatidylglycerophosphatase activity	pgpA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0195,iECSP_1301.ECSP_0485,iECUMN_1333.ECUMN_0456,iECs_1301.ECs0471,iG2583_1286.G2583_0529,iPC815.YPO3179,iZ_1308.Z0520	PgpA
TLS2_k127_3477973_1	1267535.KB906767_gene1017	2.883e-95	326.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,3Y466@57723|Acidobacteria,2JHTM@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
TLS2_k127_3477973_3	1499967.BAYZ01000181_gene4488	7.446e-36	143.0	COG1514@1|root,COG1514@2|Bacteria,2NPRT@2323|unclassified Bacteria	2|Bacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
TLS2_k127_3477973_6	1047013.AQSP01000138_gene1048	1.075e-20	94.0	COG2835@1|root,COG2835@2|Bacteria,2NQ60@2323|unclassified Bacteria	2|Bacteria	S	Trm112p-like protein	ycaR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.7.1.130	ko:K00912,ko:K09791	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Trm112p
TLS2_k127_3477973_4	330214.NIDE3023	7.323e-27	123.0	COG0859@1|root,COG0859@2|Bacteria,3J161@40117|Nitrospirae	40117|Nitrospirae	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TLS2_k127_3477973_2	398767.Glov_0977	1.33e-82	285.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria,43TN4@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1,7-bisphosphate	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_0922	CTP_transf_like,PfkB
TLS2_k127_3477973_8	1267533.KB906737_gene1962	1.77e-09	59.0	COG0622@1|root,COG0622@2|Bacteria,3Y51P@57723|Acidobacteria,2JJEG@204432|Acidobacteriia	204432|Acidobacteriia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
TLS2_k127_3489567_0	794903.OPIT5_11855	3.647e-86	308.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Glyco_hydro_2_C,Glycos_transf_2
TLS2_k127_3494786_2	81824.XP_001746840.1	2.769e-34	133.0	COG0133@1|root,COG0159@1|root,KOG1395@2759|Eukaryota,KOG4175@2759|Eukaryota,38GS5@33154|Opisthokonta	33154|Opisthokonta	E	tryptophan synthase	-	-	4.2.1.20	ko:K01694,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,PRAI,Trp_syntA
TLS2_k127_3494786_1	671143.DAMO_1413	2.812e-60	217.0	COG0159@1|root,COG0159@2|Bacteria,2NP9W@2323|unclassified Bacteria	2|Bacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
TLS2_k127_3494786_0	234267.Acid_7885	1.196e-137	446.0	COG2876@1|root,COG2876@2|Bacteria,3Y2SV@57723|Acidobacteria	57723|Acidobacteria	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
TLS2_k127_3494786_3	1167006.UWK_02007	2.078e-11	75.0	28IX5@1|root,2Z8V5@2|Bacteria,1R5YH@1224|Proteobacteria,42NTD@68525|delta/epsilon subdivisions,2WM4I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3505480_0	1408473.JHXO01000008_gene2886	1.165e-207	673.0	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,2FS4M@200643|Bacteroidia	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
TLS2_k127_3505480_1	1403819.BATR01000092_gene2658	7.301e-72	248.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_3509235_1	1173025.GEI7407_0968	2.01e-37	156.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gumK	-	2.4.1.264	ko:K07011,ko:K13659	-	-	R09732	RC00005,RC00049	ko00000,ko01000,ko01003	-	GT70	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_1,Glycos_transf_2
TLS2_k127_3509235_0	324602.Caur_3784	1.081e-63	233.0	COG0438@1|root,COG0438@2|Bacteria,2G7W9@200795|Chloroflexi,3772B@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4
TLS2_k127_3509776_0	443143.GM18_4304	1.707e-20	106.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
TLS2_k127_3509776_2	1237149.C900_00425	4.235e-08	62.0	28X9A@1|root,2ZJ7D@2|Bacteria,4P6SQ@976|Bacteroidetes,47WWT@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3510630_0	99598.Cal7507_5042	3.61e-130	426.0	COG1960@1|root,COG1960@2|Bacteria,1G4K8@1117|Cyanobacteria,1HU4P@1161|Nostocales	1117|Cyanobacteria	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3510630_3	1026882.MAMP_01558	1.258e-11	76.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,460MK@72273|Thiotrichales	72273|Thiotrichales	M	Lipid A biosynthesis	lpxL	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
TLS2_k127_3510630_1	309801.trd_A0899	9.982e-120	398.0	COG1060@1|root,COG1060@2|Bacteria,2GBD4@200795|Chloroflexi,27YV4@189775|Thermomicrobia	189775|Thermomicrobia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
TLS2_k127_3510630_2	525904.Tter_2623	2.377e-26	111.0	COG1060@1|root,COG1060@2|Bacteria,2NP8W@2323|unclassified Bacteria	2|Bacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	fbiC	-	1.21.98.1,2.5.1.77	ko:K11779,ko:K11784	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396	RC01381,RC02329,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC,Radical_SAM
TLS2_k127_3515720_1	1499967.BAYZ01000048_gene2693	1.765e-68	239.0	COG0488@1|root,COG0488@2|Bacteria	2|Bacteria	L	(ABC) transporter	-	-	-	ko:K15738,ko:K18231	ko02010,map02010	-	-	-	br01600,ko00000,ko00001,ko01504,ko02000	3.A.1.120.6,3.A.1.121.1,3.A.1.121.3	-	-	ABC_tran
TLS2_k127_3515720_2	234267.Acid_0448	1.2e-62	221.0	COG2318@1|root,COG2318@2|Bacteria,3Y85M@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_3515720_0	204669.Acid345_3040	7.716e-141	462.0	COG3653@1|root,COG3653@2|Bacteria,3Y3Q2@57723|Acidobacteria,2JJ0K@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
TLS2_k127_3515720_3	204669.Acid345_3459	4.779e-32	131.0	COG0577@1|root,COG0577@2|Bacteria,3Y6B8@57723|Acidobacteria,2JK7N@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_352114_0	1396418.BATQ01000181_gene833	9.9e-151	489.0	COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,46T85@74201|Verrucomicrobia	74201|Verrucomicrobia	OU	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PD40,PDZ_2,Peptidase_M28
TLS2_k127_352114_2	706587.Desti_1801	1.015e-56	206.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,43BI9@68525|delta/epsilon subdivisions,2X6WN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS2_k127_352114_3	1157943.KB892705_gene2918	4.268e-53	194.0	COG5483@1|root,COG5483@2|Bacteria,2IHSH@201174|Actinobacteria,239GM@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
TLS2_k127_352114_1	1173028.ANKO01000017_gene246	3.383e-120	391.0	COG0309@1|root,COG0309@2|Bacteria,1G1Z7@1117|Cyanobacteria,1H82T@1150|Oscillatoriales	1117|Cyanobacteria	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
TLS2_k127_3527025_3	1382356.JQMP01000003_gene1325	4.261e-22	95.0	COG1012@1|root,COG1012@2|Bacteria,2G5JZ@200795|Chloroflexi,27Y57@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the aldehyde dehydrogenase family	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS2_k127_3527025_0	1382359.JIAL01000001_gene754	2.308e-139	453.0	COG0686@1|root,COG0686@2|Bacteria,3Y3Y9@57723|Acidobacteria,2JI1M@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TLS2_k127_3527025_2	1047013.AQSP01000111_gene1686	2.156e-31	133.0	COG0095@1|root,COG0095@2|Bacteria,2NPP1@2323|unclassified Bacteria	2|Bacteria	H	Biotin/lipoate A/B protein ligase family	lipM	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TLS2_k127_3527025_1	1297742.A176_01841	3.542e-66	243.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,42MTI@68525|delta/epsilon subdivisions,2WIXW@28221|Deltaproteobacteria,2YUQ9@29|Myxococcales	28221|Deltaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
TLS2_k127_3528797_3	1340493.JNIF01000003_gene1832	9.16e-40	150.0	COG0620@1|root,COG0620@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
TLS2_k127_3528797_1	234267.Acid_1371	1.055e-154	493.0	COG0451@1|root,COG0451@2|Bacteria,3Y3T4@57723|Acidobacteria	57723|Acidobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_3528797_0	234267.Acid_1372	1.178e-183	581.0	COG0247@1|root,COG0247@2|Bacteria,3Y3K8@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
TLS2_k127_3528797_2	1267535.KB906767_gene1184	2.732e-46	168.0	COG0247@1|root,COG0247@2|Bacteria,3Y3K8@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
TLS2_k127_3539390_2	1227739.Hsw_1554	1.495e-129	421.0	COG0702@1|root,COG0702@2|Bacteria,4NEJF@976|Bacteroidetes,47MFP@768503|Cytophagia	976|Bacteroidetes	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,Epimerase,NAD_binding_10
TLS2_k127_3539390_5	1033734.CAET01000048_gene1636	5.166e-25	108.0	COG3278@1|root,COG3278@2|Bacteria,1VAHS@1239|Firmicutes,4HKKG@91061|Bacilli,1ZID0@1386|Bacillus	91061|Bacilli	O	COG3278 Cbb3-type cytochrome oxidase, subunit 1	-	-	-	-	-	-	-	-	-	-	-	-	COX1
TLS2_k127_3539390_6	926550.CLDAP_18140	0.0004264	51.0	COG3381@1|root,COG3381@2|Bacteria	2|Bacteria	S	protein complex oligomerization	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
TLS2_k127_3539390_4	926550.CLDAP_18150	4.094e-28	125.0	COG2180@1|root,COG2180@2|Bacteria	2|Bacteria	C	chaperone-mediated protein complex assembly	narJ	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057	-	ko:K00373,ko:K17052	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	5.A.3.8	-	iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,ic_1306.c1687	Nitrate_red_del
TLS2_k127_3539390_1	713586.KB900536_gene1341	6.232e-168	537.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,1RNMJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	nitrate reductase beta subunit	-	-	1.7.5.1	ko:K00371,ko:K17051	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	-	Fer4_11
TLS2_k127_3539390_0	1158150.KB906246_gene1915	0.0	1384.0	COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,1T2GI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.5.1,1.8.5.3	ko:K00370,ko:K07306,ko:K17050	ko00910,ko00920,ko01120,ko02020,map00910,map00920,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497,R09501	RC02555,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.3,5.A.3.8	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
TLS2_k127_3539390_3	1125863.JAFN01000001_gene2793	2.7e-58	213.0	COG2010@1|root,COG3258@1|root,COG2010@2|Bacteria,COG3258@2|Bacteria,1RJJ2@1224|Proteobacteria,42SCM@68525|delta/epsilon subdivisions,2WPS4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c	pcmF	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
TLS2_k127_3543065_1	530564.Psta_0198	5.207e-78	271.0	COG0583@1|root,COG0583@2|Bacteria,2IYFV@203682|Planctomycetes	203682|Planctomycetes	K	COG0583 Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_3543065_0	404589.Anae109_0854	0.0	1784.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJBR@28221|Deltaproteobacteria,2YUAD@29|Myxococcales	28221|Deltaproteobacteria	E	Glutamate synthase	gltB1	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TLS2_k127_3544440_2	401053.AciPR4_0941	1.058e-33	149.0	COG2304@1|root,COG2304@2|Bacteria,3Y483@57723|Acidobacteria,2JI1N@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_3544440_1	118163.Ple7327_1772	1.263e-62	228.0	COG1216@1|root,COG1216@2|Bacteria,1G0PG@1117|Cyanobacteria	1117|Cyanobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_3544440_0	65393.PCC7424_4196	5.172e-86	294.0	COG1232@1|root,COG1232@2|Bacteria,1G05M@1117|Cyanobacteria,3KGQ6@43988|Cyanothece	1117|Cyanobacteria	H	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS2_k127_3550944_3	1122221.JHVI01000026_gene1308	0.0005123	43.0	2DNRM@1|root,32YT2@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
TLS2_k127_3550944_0	285535.JOEY01000022_gene693	1.778e-31	136.0	COG5563@1|root,COG5563@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Collagen
TLS2_k127_3550944_1	926566.Terro_3035	4.471e-28	118.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07061	-	-	-	-	ko00000,ko02048	-	-	-	NTP_transf_2
TLS2_k127_3550944_2	616991.JPOO01000001_gene3365	1.691e-07	52.0	COG0385@1|root,COG0385@2|Bacteria,4NEIM@976|Bacteroidetes,1HY0F@117743|Flavobacteriia,23GWH@178469|Arenibacter	2|Bacteria	S	SBF-like CPA transporter family (DUF4137)	-	-	-	ko:K03453,ko:K14347	-	-	-	-	ko00000,ko02000,ko04147	2.A.28,2.A.93.1	-	-	SBF,SBF_like
TLS2_k127_3554283_2	414996.IL38_13600	4.711e-33	136.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,408P4@622450|Actinopolysporales	201174|Actinobacteria	KLT	PASTA	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_3554283_1	401053.AciPR4_3116	8.898e-208	657.0	COG0519@1|root,COG0519@2|Bacteria,3Y3VV@57723|Acidobacteria,2JHRV@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
TLS2_k127_3554283_0	204669.Acid345_2747	0.0	1151.0	COG0587@1|root,COG0587@2|Bacteria,3Y2TS@57723|Acidobacteria,2JIA9@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA-directed DNA polymerase	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
TLS2_k127_3559811_2	596152.DesU5LDRAFT_2105	4.09e-67	244.0	COG1215@1|root,COG1215@2|Bacteria,1N14A@1224|Proteobacteria,42P20@68525|delta/epsilon subdivisions,2WMIC@28221|Deltaproteobacteria,2M9GK@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_3559811_3	479434.Sthe_0904	1.762e-43	171.0	COG0438@1|root,COG0438@2|Bacteria,2G5PS@200795|Chloroflexi,27XVU@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_3559811_1	1242864.D187_009058	1.733e-100	329.0	COG0431@1|root,COG0431@2|Bacteria,1MXQ8@1224|Proteobacteria,433WV@68525|delta/epsilon subdivisions,2X8XD@28221|Deltaproteobacteria,2YXH7@29|Myxococcales	28221|Deltaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS2_k127_3559811_0	234267.Acid_3464	1.237e-201	636.0	COG3669@1|root,COG3669@2|Bacteria,3Y43P@57723|Acidobacteria	2|Bacteria	G	PFAM glycoside hydrolase, family 29	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,TAT_signal
TLS2_k127_3560203_2	278963.ATWD01000002_gene437	0.0002068	51.0	COG2823@1|root,COG2823@2|Bacteria,3Y4FV@57723|Acidobacteria,2JJ5I@204432|Acidobacteriia	204432|Acidobacteriia	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS2_k127_3560203_1	234267.Acid_4507	3.451e-128	427.0	COG0366@1|root,COG0366@2|Bacteria,3Y2P1@57723|Acidobacteria	57723|Acidobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
TLS2_k127_3560203_0	1255043.TVNIR_1782	4.622e-131	423.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,1RSP8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
TLS2_k127_3567009_4	204669.Acid345_2626	1.2e-54	195.0	COG0005@1|root,COG0005@2|Bacteria,3Y2MA@57723|Acidobacteria,2JI5Q@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_3567009_2	338966.Ppro_0432	2.913e-121	397.0	COG0524@1|root,COG0524@2|Bacteria,1Q8Y3@1224|Proteobacteria,42NSV@68525|delta/epsilon subdivisions,2WJWD@28221|Deltaproteobacteria,43S1S@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	PFAM PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_2683	PfkB
TLS2_k127_3567009_6	179408.Osc7112_4339	6.189e-22	110.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_8
TLS2_k127_3567009_3	247490.KSU1_D0154	2.436e-71	251.0	COG1226@1|root,2ZCE6@2|Bacteria	2|Bacteria	P	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2
TLS2_k127_3567009_1	1123073.KB899244_gene261	2.674e-196	652.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X5CT@135614|Xanthomonadales	135614|Xanthomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
TLS2_k127_3567009_0	1121930.AQXG01000001_gene1203	1.137e-301	960.0	COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
TLS2_k127_3567009_5	880073.Calab_1194	1.468e-33	138.0	COG0845@1|root,COG0845@2|Bacteria,2NR7K@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
TLS2_k127_3568711_1	278963.ATWD01000001_gene1577	1.725e-50	181.0	COG1695@1|root,COG1695@2|Bacteria,3Y873@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_3568711_0	1267533.KB906733_gene2950	1.149e-55	207.0	COG0577@1|root,COG0577@2|Bacteria,3Y74R@57723|Acidobacteria,2JM1S@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_3579984_0	234267.Acid_0024	4.027e-143	483.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_3585150_0	234267.Acid_1990	3.457e-310	985.0	COG1629@1|root,COG4771@2|Bacteria,3Y3YH@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_3585150_1	1173025.GEI7407_0339	5.235e-08	63.0	COG0438@1|root,COG0457@1|root,COG0859@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4915,Glyco_transf_9,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
TLS2_k127_3590209_0	1128421.JAGA01000002_gene1758	1.279e-42	171.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria	2|Bacteria	D	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	GATase1_like,VWA,VWA_2,VWA_3
TLS2_k127_3590209_2	383372.Rcas_4187	2.088e-39	151.0	COG1853@1|root,COG1853@2|Bacteria,2G6XG@200795|Chloroflexi,375VA@32061|Chloroflexia	32061|Chloroflexia	S	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TLS2_k127_3590209_3	1232437.KL662010_gene1557	6.576e-29	122.0	COG1853@1|root,COG1853@2|Bacteria,1QNV2@1224|Proteobacteria,42TD3@68525|delta/epsilon subdivisions,2WPRM@28221|Deltaproteobacteria,2MK7Y@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TLS2_k127_3590209_1	1121385.AQXW01000004_gene2733	4.119e-40	165.0	COG0477@1|root,COG2814@2|Bacteria,2GK1K@201174|Actinobacteria,1ZWM6@145357|Dermacoccaceae	201174|Actinobacteria	EGP	MFS/sugar transport protein	blt	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_3614321_2	518766.Rmar_1602	1.118e-16	91.0	COG5012@1|root,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,HTH_3
TLS2_k127_3614321_0	479434.Sthe_2631	5.064e-97	325.0	COG0506@1|root,COG0506@2|Bacteria,2G6B6@200795|Chloroflexi,27XF7@189775|Thermomicrobia	189775|Thermomicrobia	C	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
TLS2_k127_3614321_1	639030.JHVA01000001_gene186	5.968e-45	170.0	COG0624@1|root,COG0624@2|Bacteria,3Y2K0@57723|Acidobacteria,2JIEY@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM peptidase	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_3626349_0	1304885.AUEY01000046_gene4	4.295e-29	123.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2WQA9@28221|Deltaproteobacteria,2MKZ2@213118|Desulfobacterales	28221|Deltaproteobacteria	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_3626349_3	1131269.AQVV01000031_gene291	5.518e-09	64.0	2DTSQ@1|root,33MH7@2|Bacteria	2|Bacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_3626349_1	1297742.A176_04484	1.513e-27	122.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,42TQG@68525|delta/epsilon subdivisions,2WQG8@28221|Deltaproteobacteria,2YW3V@29|Myxococcales	28221|Deltaproteobacteria	S	Smr domain	-	-	-	-	-	-	-	-	-	-	-	-	Smr
TLS2_k127_3626349_2	1340493.JNIF01000003_gene3542	3.173e-09	66.0	2C9TJ@1|root,2ZFZD@2|Bacteria,3Y970@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3630065_0	861299.J421_5621	2.488e-94	319.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_3630065_1	373994.Riv7116_3284	1.37e-83	288.0	COG4223@1|root,COG4223@2|Bacteria	2|Bacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	elrF	-	-	-	-	-	-	-	-	-	-	-	Cutinase,DUF1350,DUF1631
TLS2_k127_3630065_3	68199.JNZO01000018_gene6833	4.642e-18	96.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
TLS2_k127_3630065_2	1131269.AQVV01000009_gene1093	3.526e-46	181.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
TLS2_k127_3634511_1	1267535.KB906767_gene5475	1.699e-64	223.0	COG0005@1|root,COG0005@2|Bacteria,3Y2MA@57723|Acidobacteria,2JI5Q@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_3634511_0	330214.NIDE3119	1.93e-79	275.0	COG0491@1|root,COG0491@2|Bacteria,3J1C9@40117|Nitrospirae	40117|Nitrospirae	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_3634511_2	204669.Acid345_2365	4.645e-61	218.0	COG1703@1|root,COG1703@2|Bacteria,3Y40X@57723|Acidobacteria,2JHW8@204432|Acidobacteriia	204432|Acidobacteriia	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS2_k127_3635800_0	266117.Rxyl_2835	3.238e-52	191.0	COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,4CPVX@84995|Rubrobacteria	84995|Rubrobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS2_k127_3635800_2	671143.DAMO_2813	1.222e-35	141.0	COG1102@1|root,COG1102@2|Bacteria,2NRB0@2323|unclassified Bacteria	2|Bacteria	F	Cytidylate kinase-like family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Cytidylate_kin2,GAF_2,Pribosyltran
TLS2_k127_3635800_1	240015.ACP_1748	2.16e-44	166.0	COG0590@1|root,COG0590@2|Bacteria,3Y4KB@57723|Acidobacteria,2JJC6@204432|Acidobacteriia	204432|Acidobacteriia	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	DUF3175,MafB19-deam
TLS2_k127_365599_4	211165.AJLN01000104_gene6514	5.183e-79	269.0	COG1215@1|root,COG1215@2|Bacteria,1FZXF@1117|Cyanobacteria,1JGTG@1189|Stigonemataceae	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_365599_0	247490.KSU1_D0498	5.976e-256	800.0	COG2192@1|root,COG2192@2|Bacteria,2IYCS@203682|Planctomycetes	203682|Planctomycetes	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TLS2_k127_365599_2	479434.Sthe_3175	2.196e-108	360.0	COG1215@1|root,COG1215@2|Bacteria,2GBB7@200795|Chloroflexi,27YX2@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_365599_6	395961.Cyan7425_0947	5.139e-58	213.0	COG2323@1|root,COG2323@2|Bacteria,1G658@1117|Cyanobacteria,3KIXI@43988|Cyanothece	1117|Cyanobacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
TLS2_k127_365599_1	479434.Sthe_3174	5.059e-148	474.0	COG0535@1|root,COG0535@2|Bacteria,2G75Y@200795|Chloroflexi	200795|Chloroflexi	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
TLS2_k127_365599_3	479434.Sthe_3172	1.612e-105	351.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	2.4.1.268,2.4.1.83	ko:K00721,ko:K07011,ko:K12990,ko:K14597,ko:K21349	ko00510,ko00906,ko01100,ko02024,ko02025,map00510,map00906,map01100,map02024,map02025	-	R01009,R07544,R07546	RC00005,RC00262	ko00000,ko00001,ko01000,ko01003,ko01005	-	GT2,GT81	-	Glycos_transf_2
TLS2_k127_365599_5	313612.L8106_26087	3.47e-67	241.0	28JN3@1|root,2Z9EI@2|Bacteria,1G3ZH@1117|Cyanobacteria,1H6ZA@1150|Oscillatoriales	1117|Cyanobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
TLS2_k127_365599_7	926550.CLDAP_28790	3.233e-45	175.0	COG0477@1|root,COG2814@2|Bacteria,2GBP2@200795|Chloroflexi	200795|Chloroflexi	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_36578_4	1267535.KB906767_gene5245	1.436e-65	239.0	COG1629@1|root,COG4771@2|Bacteria,3Y2R5@57723|Acidobacteria,2JIK7@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_36578_3	234267.Acid_5255	2.45e-70	247.0	2B11W@1|root,31TFA@2|Bacteria,3Y4Z8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_36578_2	234267.Acid_5542	2.049e-72	248.0	COG0221@1|root,COG0221@2|Bacteria,3Y3UZ@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
TLS2_k127_36578_5	1340493.JNIF01000003_gene4475	8.16e-35	140.0	COG2318@1|root,COG2318@2|Bacteria,3Y8H7@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
TLS2_k127_36578_0	234267.Acid_5541	2.569e-78	272.0	COG0030@1|root,COG0030@2|Bacteria,3Y3RQ@57723|Acidobacteria	57723|Acidobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TLS2_k127_36578_7	234267.Acid_5540	1.289e-29	126.0	COG5662@1|root,COG5662@2|Bacteria,3Y4JS@57723|Acidobacteria	57723|Acidobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_36578_1	234267.Acid_5539	6.661e-78	266.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_36578_6	1347087.CBYO010000011_gene1824	5.095e-33	143.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HB7D@91061|Bacilli	91061|Bacilli	O	Belongs to the peptidase S8 family	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	PPC,Peptidase_S8
TLS2_k127_36578_8	234267.Acid_4231	2.29e-12	68.0	COG2332@1|root,COG2332@2|Bacteria,3Y57C@57723|Acidobacteria	57723|Acidobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
TLS2_k127_3665014_3	1265505.ATUG01000001_gene3506	1.338e-64	232.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42NEW@68525|delta/epsilon subdivisions,2WJNJ@28221|Deltaproteobacteria,2MIGM@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM lipopolysaccharide heptosyltransferase II	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TLS2_k127_3665014_5	1125863.JAFN01000001_gene3418	1.455e-60	222.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,42PA2@68525|delta/epsilon subdivisions,2WNJ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
TLS2_k127_3665014_1	398767.Glov_0770	5.817e-88	306.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,42PCH@68525|delta/epsilon subdivisions,2WMQM@28221|Deltaproteobacteria,43TBC@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
TLS2_k127_3665014_4	204669.Acid345_1221	3.561e-63	218.0	COG0048@1|root,COG0048@2|Bacteria,3Y4JQ@57723|Acidobacteria,2JJ7D@204432|Acidobacteriia	204432|Acidobacteriia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
TLS2_k127_3665014_2	644282.Deba_2942	9.667e-67	231.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,42QR7@68525|delta/epsilon subdivisions,2WNFM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
TLS2_k127_3665014_0	243231.GSU2860	1.073e-278	868.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_3699945_3	211165.AJLN01000141_gene2471	5.846e-151	487.0	COG0520@1|root,COG0520@2|Bacteria,1G0VG@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_3699945_1	1267535.KB906767_gene773	6.322e-204	640.0	COG0524@1|root,COG0524@2|Bacteria,3Y3DE@57723|Acidobacteria,2JI9I@204432|Acidobacteriia	204432|Acidobacteriia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS2_k127_3699945_4	1382359.JIAL01000001_gene783	2.793e-41	160.0	COG1595@1|root,COG1595@2|Bacteria,3Y4HK@57723|Acidobacteria,2JJAJ@204432|Acidobacteriia	204432|Acidobacteriia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_3699945_2	1121335.Clst_0783	7.784e-164	525.0	COG0524@1|root,COG0524@2|Bacteria,1TRRY@1239|Firmicutes,248Y3@186801|Clostridia,3WHKM@541000|Ruminococcaceae	186801|Clostridia	G	Kinase, PfkB family	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
TLS2_k127_3699945_0	313628.LNTAR_14462	3.829e-240	755.0	COG3459@1|root,COG3459@2|Bacteria	2|Bacteria	G	carbohydrate binding	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36
TLS2_k127_3703465_1	671143.DAMO_1660	6.15e-38	152.0	COG1612@1|root,COG1612@2|Bacteria,2NQ3D@2323|unclassified Bacteria	2|Bacteria	O	Cytochrome oxidase assembly protein	ctaA	-	-	ko:K02259,ko:K03110	ko00190,ko00860,ko01100,ko01110,ko02020,ko02024,ko03060,ko03070,ko04714,map00190,map00860,map01100,map01110,map02020,map02024,map03060,map03070,map04714	M00154,M00335	R07412	RC00769	ko00000,ko00001,ko00002,ko02044,ko03029	3.A.5.1,3.A.5.2,3.A.5.7,3.D.4.4	-	-	COX15-CtaA
TLS2_k127_3703465_2	477974.Daud_0525	5.05e-28	123.0	COG0546@1|root,COG0546@2|Bacteria,1TPPZ@1239|Firmicutes,24GK6@186801|Clostridia,261XX@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	ppaX	-	3.1.3.18,3.6.1.1	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_3703465_0	880073.Calab_1301	1.759e-96	325.0	COG1242@1|root,COG1242@2|Bacteria,2NQDF@2323|unclassified Bacteria	2|Bacteria	S	Radical_SAM C-terminal domain	yhcC	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
TLS2_k127_3703465_5	497964.CfE428DRAFT_0112	7.83e-09	64.0	COG0775@1|root,COG0775@2|Bacteria,46WRQ@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Phosphorylase superfamily	pfs	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_3703465_4	714961.BFZC1_10927	3.794e-11	73.0	COG4758@1|root,COG4758@2|Bacteria,1V9SU@1239|Firmicutes,4HJWC@91061|Bacilli,3IXDT@400634|Lysinibacillus	91061|Bacilli	S	N-terminal domain of toast_rack, DUF2154	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154,Toast_rack_N
TLS2_k127_3703465_3	1340493.JNIF01000003_gene1692	9.493e-16	91.0	COG3595@1|root,COG3595@2|Bacteria,3Y3K3@57723|Acidobacteria	57723|Acidobacteria	C	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_3705144_1	1047013.AQSP01000074_gene1894	2.251e-64	224.0	COG0201@1|root,COG0201@2|Bacteria,2NNVK@2323|unclassified Bacteria	2|Bacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
TLS2_k127_3705144_3	555079.Toce_0137	1.73e-56	200.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,24HAJ@186801|Clostridia,42G84@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
TLS2_k127_3705144_8	1267534.KB906757_gene803	3.496e-13	72.0	COG1841@1|root,COG1841@2|Bacteria,3Y5I2@57723|Acidobacteria,2JJZB@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
TLS2_k127_3705144_2	335543.Sfum_1572	1.817e-60	214.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,2MRKN@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Belongs to the universal ribosomal protein uS5 family	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
TLS2_k127_3705144_6	234267.Acid_5102	5.326e-39	149.0	COG0256@1|root,COG0256@2|Bacteria,3Y5CH@57723|Acidobacteria	57723|Acidobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
TLS2_k127_3705144_4	204536.SULAZ_1740	5.895e-52	191.0	COG0097@1|root,COG0097@2|Bacteria,2G3Z5@200783|Aquificae	200783|Aquificae	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
TLS2_k127_3705144_5	883077.HMPREF9241_01281	1.208e-40	153.0	COG0096@1|root,COG0096@2|Bacteria,2IHQZ@201174|Actinobacteria,4D5IC@85005|Actinomycetales	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
TLS2_k127_3705144_7	335543.Sfum_1568	7.073e-24	101.0	COG0199@1|root,COG0199@2|Bacteria,1PDMJ@1224|Proteobacteria,42VCE@68525|delta/epsilon subdivisions,2WR7W@28221|Deltaproteobacteria,2MS3E@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
TLS2_k127_3705144_0	66692.ABC0162	2.005e-76	260.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,4HBAX@91061|Bacilli,1ZB6T@1386|Bacillus	91061|Bacilli	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
TLS2_k127_3711190_1	1321781.HMPREF1985_01645	3.393e-48	188.0	COG4632@1|root,COG4632@2|Bacteria,1TQBV@1239|Firmicutes,4H1VN@909932|Negativicutes	909932|Negativicutes	G	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	AMIN,NAGPA
TLS2_k127_3711190_0	1300345.LF41_1080	1.234e-151	494.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria,1XA6G@135614|Xanthomonadales	135614|Xanthomonadales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3714456_2	1223521.BBJX01000005_gene1808	0.0005754	52.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,2VM32@28216|Betaproteobacteria,4AD9Q@80864|Comamonadaceae	28216|Betaproteobacteria	M	TIGRFAM TonB family protein	tonB	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TLS2_k127_3714456_0	1185876.BN8_02234	1.016e-133	435.0	COG0627@1|root,COG0627@2|Bacteria,4NIU8@976|Bacteroidetes,47NUH@768503|Cytophagia	976|Bacteroidetes	E	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
TLS2_k127_3714456_1	479434.Sthe_0641	2.051e-12	69.0	COG1983@1|root,COG1983@2|Bacteria	2|Bacteria	KT	positive regulation of macromolecule biosynthetic process	pspC	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
TLS2_k127_3743935_1	234267.Acid_2734	7.604e-68	246.0	COG1629@1|root,COG4771@2|Bacteria,3Y2WI@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_3743935_0	1123487.KB892835_gene3378	1.37e-92	318.0	COG1055@1|root,COG1055@2|Bacteria,1NEVR@1224|Proteobacteria,2VM0X@28216|Betaproteobacteria,2KZVH@206389|Rhodocyclales	206389|Rhodocyclales	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
TLS2_k127_3744207_2	671143.DAMO_2488	8.493e-46	169.0	COG1459@1|root,COG1459@2|Bacteria,2NP2J@2323|unclassified Bacteria	2|Bacteria	U	Type II secretion system (T2SS), protein F	xpsF	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
TLS2_k127_3744207_0	765912.Thimo_0046	1.179e-49	181.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1WY8U@135613|Chromatiales	135613|Chromatiales	U	general secretion pathway protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
TLS2_k127_3744207_6	1207076.ALAT01000215_gene4137	0.000955	49.0	COG4970@1|root,COG4970@2|Bacteria,1NBWI@1224|Proteobacteria,1S5MN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	general secretion pathway protein	xpsH	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspH,N_methyl
TLS2_k127_3744207_5	1123377.AUIV01000012_gene768	9.651e-08	59.0	COG4967@1|root,COG4967@2|Bacteria,1QWTI@1224|Proteobacteria,1T5EA@1236|Gammaproteobacteria,1XDCG@135614|Xanthomonadales	135614|Xanthomonadales	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02458	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
TLS2_k127_3744207_3	857087.Metme_2799	1.654e-09	68.0	COG4967@1|root,COG4967@2|Bacteria,1QWRS@1224|Proteobacteria	1224|Proteobacteria	U	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
TLS2_k127_3744207_1	933262.AXAM01000042_gene1817	1.183e-46	182.0	COG1555@1|root,COG3156@1|root,COG1555@2|Bacteria,COG3156@2|Bacteria,1PQMW@1224|Proteobacteria,42T9B@68525|delta/epsilon subdivisions,2WPYT@28221|Deltaproteobacteria,2MKAN@213118|Desulfobacterales	28221|Deltaproteobacteria	LU	Type II secretion system (T2SS), protein K	-	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
TLS2_k127_3744207_4	572477.Alvin_3009	1.857e-08	63.0	COG3166@1|root,COG4972@1|root,COG3166@2|Bacteria,COG4972@2|Bacteria,1RJTG@1224|Proteobacteria,1S6RT@1236|Gammaproteobacteria,1WXKF@135613|Chromatiales	135613|Chromatiales	NU	fimbrial assembly	-	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	PilM_2,PilN
TLS2_k127_3749225_0	1340493.JNIF01000003_gene1819	0.0	1063.0	COG2911@1|root,COG4775@1|root,COG2911@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K07277,ko:K09800	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	AsmA_2,Bac_surface_Ag,DUF748,POTRA,TamB
TLS2_k127_3750417_0	234267.Acid_4050	6.215e-28	132.0	COG4099@1|root,COG4099@2|Bacteria	2|Bacteria	F	phospholipase Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Abhydrolase_8,DLH,Esterase,Peptidase_S9
TLS2_k127_3750417_2	1210884.HG799466_gene12369	1.328e-06	62.0	COG0457@1|root,COG2010@1|root,COG2133@1|root,COG0457@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,2IXKV@203682|Planctomycetes	203682|Planctomycetes	C	Membrane-bound dehydrogenase domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
TLS2_k127_3751630_1	331869.BAL199_26806	2.804e-79	280.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2TQWS@28211|Alphaproteobacteria,4BPI9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Homoserine dehydrogenase, NAD binding domain	hom	GO:0003674,GO:0003824,GO:0004412,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
TLS2_k127_3751630_0	1121468.AUBR01000048_gene1658	8.701e-125	412.0	COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia,42FQX@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
TLS2_k127_3751630_2	269799.Gmet_1891	3.246e-62	229.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,42NF0@68525|delta/epsilon subdivisions,2WIJK@28221|Deltaproteobacteria,43U6A@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
TLS2_k127_3755773_1	234267.Acid_0094	3.699e-102	336.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	fadE23	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3755773_2	324602.Caur_2490	2.053e-54	201.0	COG0725@1|root,COG0725@2|Bacteria,2G6J6@200795|Chloroflexi,376NT@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
TLS2_k127_3755773_0	234267.Acid_7484	1.474e-190	597.0	COG0443@1|root,COG0443@2|Bacteria,3Y2XU@57723|Acidobacteria	57723|Acidobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TLS2_k127_3762130_6	1150469.RSPPHO_02781	2.525e-08	55.0	COG2165@1|root,COG2165@2|Bacteria,1PJ5F@1224|Proteobacteria,2VC7I@28211|Alphaproteobacteria,2JY2W@204441|Rhodospirillales	204441|Rhodospirillales	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3762130_5	1265505.ATUG01000001_gene3279	2.982e-10	69.0	2C1RS@1|root,332I6@2|Bacteria,1NFD9@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3762130_1	913865.DOT_2964	8.596e-46	172.0	COG2318@1|root,COG2318@2|Bacteria,1V8MI@1239|Firmicutes	1239|Firmicutes	S	PFAM DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
TLS2_k127_3762130_2	880073.Calab_0992	6.716e-41	163.0	COG2006@1|root,COG2006@2|Bacteria,2NQF7@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
TLS2_k127_3762130_3	1047013.AQSP01000114_gene698	6.632e-32	138.0	2CK1R@1|root,31E53@2|Bacteria,2NR8M@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3762130_0	357808.RoseRS_0589	7.754e-96	327.0	COG2199@1|root,COG3706@2|Bacteria,2G64S@200795|Chloroflexi	200795|Chloroflexi	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9
TLS2_k127_3762130_4	402777.KB235903_gene1780	1.615e-17	96.0	COG3975@1|root,COG3975@2|Bacteria,1G0YP@1117|Cyanobacteria,1H7J1@1150|Oscillatoriales	1117|Cyanobacteria	S	protease with the C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
TLS2_k127_3762820_7	926550.CLDAP_32220	3.454e-25	106.0	COG1070@1|root,COG1070@2|Bacteria,2G61N@200795|Chloroflexi	200795|Chloroflexi	G	carbohydrate kinase FGGY	-	-	2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
TLS2_k127_3762820_1	234267.Acid_1334	1.773e-125	411.0	COG0235@1|root,COG0235@2|Bacteria,3Y66P@57723|Acidobacteria	57723|Acidobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
TLS2_k127_3762820_10	794903.OPIT5_04230	5.511e-15	79.0	COG4576@1|root,COG4576@2|Bacteria,46WMY@74201|Verrucomicrobia,3K8EE@414999|Opitutae	414999|Opitutae	CQ	Ethanolamine utilisation protein EutN/carboxysome	-	-	-	-	-	-	-	-	-	-	-	-	EutN_CcmL
TLS2_k127_3762820_9	1123242.JH636435_gene1239	6.258e-18	87.0	COG4576@1|root,COG4576@2|Bacteria,2J0UQ@203682|Planctomycetes	203682|Planctomycetes	CQ	PFAM Ethanolamine utilization protein EutN carboxysome structural protein Ccml	-	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
TLS2_k127_3762820_0	234267.Acid_1333	7.082e-186	593.0	COG1012@1|root,COG1012@2|Bacteria	2|Bacteria	C	belongs to the aldehyde dehydrogenase family	eutE	GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.87	ko:K04021,ko:K13922	ko00620,ko00640,ko01100,ko01120,map00620,map00640,map01100,map01120	-	R00228,R09097	RC00004,RC00184,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS2_k127_3762820_8	530564.Psta_3283	2.384e-22	100.0	COG4576@1|root,COG4576@2|Bacteria,2J03B@203682|Planctomycetes	203682|Planctomycetes	CQ	PFAM Ethanolamine utilization protein EutN carboxysome structural protein Ccml	-	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
TLS2_k127_3762820_4	234267.Acid_1332	9.118e-34	132.0	COG4577@1|root,COG4577@2|Bacteria	2|Bacteria	CQ	ethanolamine catabolic process	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
TLS2_k127_3762820_2	530564.Psta_3282	3.785e-107	359.0	COG0282@1|root,COG0282@2|Bacteria,2IXZC@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
TLS2_k127_3762820_5	234267.Acid_1331	1.604e-31	125.0	COG4577@1|root,COG4577@2|Bacteria	2|Bacteria	CQ	ethanolamine catabolic process	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
TLS2_k127_3762820_6	575540.Isop_1625	2.948e-31	125.0	COG4577@1|root,COG4577@2|Bacteria,2J02H@203682|Planctomycetes	203682|Planctomycetes	CQ	Carbon dioxide concentrating mechanism carboxysome shell protein	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
TLS2_k127_3762820_3	234267.Acid_1330	2.558e-66	228.0	COG4869@1|root,COG4869@2|Bacteria	2|Bacteria	Q	propanediol catabolic process	-	-	2.3.1.8	ko:K15024	ko00430,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00720,map01100,map01120,map01200	M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,PTAC
TLS2_k127_3763286_3	1123242.JH636434_gene4153	5.474e-66	227.0	COG4409@1|root,COG4409@2|Bacteria,2J53Z@203682|Planctomycetes	203682|Planctomycetes	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_3763286_0	946077.W5A_04973	2.21e-260	826.0	COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,1HXYF@117743|Flavobacteriia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TLS2_k127_3763286_4	1038859.AXAU01000015_gene933	3.2e-34	135.0	2DJKR@1|root,32YT5@2|Bacteria,1NACC@1224|Proteobacteria,2UDCH@28211|Alphaproteobacteria,3K0FK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3763286_2	234267.Acid_5931	7.496e-70	245.0	COG0730@1|root,COG0730@2|Bacteria,3Y4IM@57723|Acidobacteria	57723|Acidobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_3763286_1	1499967.BAYZ01000123_gene2555	3.24e-134	441.0	COG2195@1|root,COG2195@2|Bacteria,2NPYT@2323|unclassified Bacteria	2|Bacteria	E	Cleaves the N-terminal amino acid of tripeptides	pepT	GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0034701,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045148,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M42
TLS2_k127_3772686_3	243159.AFE_2172	2.207e-64	227.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1RRTD@1236|Gammaproteobacteria,2NE3D@225057|Acidithiobacillales	225057|Acidithiobacillales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_3772686_0	743299.Acife_1236	1.703e-167	540.0	COG1306@1|root,COG1306@2|Bacteria,1MWBY@1224|Proteobacteria,1SMIH@1236|Gammaproteobacteria,2NDMU@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
TLS2_k127_3772686_4	1286093.C266_02301	3.902e-47	176.0	COG0726@1|root,COG0726@2|Bacteria,1MWUE@1224|Proteobacteria,2VQN4@28216|Betaproteobacteria,1K725@119060|Burkholderiaceae	28216|Betaproteobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_3772686_5	398767.Glov_3100	3.989e-20	93.0	COG0726@1|root,COG0726@2|Bacteria,1MWUE@1224|Proteobacteria,42QSJ@68525|delta/epsilon subdivisions,2WQ2V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_3772686_6	909663.KI867150_gene325	5.895e-07	58.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MQVC@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS2_k127_3772686_2	1254432.SCE1572_19815	4.187e-139	457.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2WK3H@28221|Deltaproteobacteria,2YZNI@29|Myxococcales	28221|Deltaproteobacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
TLS2_k127_3772686_1	1254432.SCE1572_19820	4.025e-158	503.0	COG4864@1|root,COG4864@2|Bacteria,1MWP0@1224|Proteobacteria,42N9I@68525|delta/epsilon subdivisions,2WK7G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	UPF0365 protein	-	-	-	-	-	-	-	-	-	-	-	-	YdfA_immunity
TLS2_k127_3778160_2	204669.Acid345_3631	4.421e-102	344.0	COG0771@1|root,COG0771@2|Bacteria,3Y2JK@57723|Acidobacteria,2JHQF@204432|Acidobacteriia	204432|Acidobacteriia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_3778160_0	156889.Mmc1_0756	4.694e-114	378.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2TRUG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
TLS2_k127_3778160_3	370438.PTH_1865	8.839e-91	316.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,260TC@186807|Peptococcaceae	186801|Clostridia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_3778160_1	264732.Moth_0838	1.174e-111	372.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,42ETI@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_378885_4	879243.Poras_1722	5.664e-94	310.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,4NE85@976|Bacteroidetes,2FNPE@200643|Bacteroidia,22WPF@171551|Porphyromonadaceae	976|Bacteroidetes	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumB	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
TLS2_k127_378885_2	886293.Sinac_4418	5.142e-128	426.0	COG5434@1|root,COG5434@2|Bacteria,2J4KC@203682|Planctomycetes	203682|Planctomycetes	M	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_378885_5	861299.J421_1452	1.264e-14	80.0	297M3@1|root,2ZUU3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_378885_3	452637.Oter_3044	3.947e-102	344.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,Ig_3,LRR_5
TLS2_k127_378885_1	368408.Tpen_1559	2.906e-142	468.0	COG2407@1|root,arCOG01772@2157|Archaea	2157|Archaea	G	L-fucose isomerase and related	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_378885_0	204669.Acid345_4484	6.82e-290	920.0	COG3250@1|root,COG3250@2|Bacteria,3Y47P@57723|Acidobacteria,2JKBC@204432|Acidobacteriia	204432|Acidobacteriia	G	Beta galactosidase small chain	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TLS2_k127_3803501_1	234267.Acid_6247	6.464e-70	253.0	COG0673@1|root,COG0673@2|Bacteria,3Y39X@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_3803501_2	1150600.ADIARSV_0055	2.346e-15	91.0	28MHM@1|root,2ZAUH@2|Bacteria,4NKMG@976|Bacteroidetes,1IWWX@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3803501_0	1123508.JH636440_gene2300	6.074e-89	296.0	COG1793@1|root,COG1793@2|Bacteria,2IYJZ@203682|Planctomycetes	203682|Planctomycetes	L	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_3807660_0	234267.Acid_7874	5.665e-50	190.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_3807660_1	234267.Acid_7875	1.046e-27	121.0	COG0747@1|root,COG0747@2|Bacteria,3Y86U@57723|Acidobacteria	57723|Acidobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
TLS2_k127_381013_3	1449049.JONW01000008_gene759	4.827e-71	246.0	COG1735@1|root,COG1735@2|Bacteria,1NPYS@1224|Proteobacteria,2U1F9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
TLS2_k127_381013_1	1379698.RBG1_1C00001G0205	9.833e-89	301.0	COG0648@1|root,COG0648@2|Bacteria,2NNN3@2323|unclassified Bacteria	2|Bacteria	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
TLS2_k127_381013_4	1499967.BAYZ01000068_gene1971	4.455e-62	225.0	COG1994@1|root,COG1994@2|Bacteria,2NP89@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
TLS2_k127_381013_5	234267.Acid_5168	3.206e-33	130.0	COG0776@1|root,COG0776@2|Bacteria,3Y4U4@57723|Acidobacteria	57723|Acidobacteria	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_381013_2	926569.ANT_11190	4.48e-75	256.0	COG0717@1|root,COG0717@2|Bacteria,2G7HJ@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
TLS2_k127_381013_0	429009.Adeg_1804	4.928e-315	984.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,42ER6@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
TLS2_k127_3810219_2	1382356.JQMP01000003_gene2156	2.862e-07	63.0	COG3307@1|root,COG3307@2|Bacteria,2G6B1@200795|Chloroflexi,27XFU@189775|Thermomicrobia	189775|Thermomicrobia	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TLS2_k127_3810219_0	398511.BpOF4_06545	1.274e-43	178.0	COG2244@1|root,COG2244@2|Bacteria,1TPSH@1239|Firmicutes,4HAGX@91061|Bacilli,1ZDDM@1386|Bacillus	91061|Bacilli	S	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid	tuaB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03328,ko:K16694,ko:K16695	-	-	-	-	ko00000,ko02000	2.A.66.2,2.A.66.2.6,2.A.66.2.7	-	iYO844.BSU35600	Polysacc_synt_3,Polysacc_synt_C
TLS2_k127_3810219_1	1122917.KB899665_gene4044	4.085e-35	149.0	COG0438@1|root,COG0438@2|Bacteria,1TQN3@1239|Firmicutes,4HCKM@91061|Bacilli,26R4Q@186822|Paenibacillaceae	91061|Bacilli	M	Glycosyl transferase	rfaG1	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_381534_0	1267535.KB906767_gene4837	1.197e-201	654.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_381534_4	314230.DSM3645_26789	4.976e-11	74.0	2DZX2@1|root,32VM6@2|Bacteria,2J2WS@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_381534_2	1267535.KB906767_gene3810	1.171e-150	494.0	COG0457@1|root,COG0457@2|Bacteria	1267535.KB906767_gene3810|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_381534_3	269799.Gmet_2032	1.613e-12	80.0	COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,42P80@68525|delta/epsilon subdivisions,2WMCB@28221|Deltaproteobacteria,43TGI@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
TLS2_k127_381534_1	1047013.AQSP01000067_gene2200	4.166e-193	622.0	COG3379@1|root,COG3379@2|Bacteria,2NQA7@2323|unclassified Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_3826330_0	1122931.AUAE01000030_gene840	3.173e-40	157.0	COG4948@1|root,COG4948@2|Bacteria,4PKP3@976|Bacteroidetes,2FMI4@200643|Bacteroidia,22W6G@171551|Porphyromonadaceae	976|Bacteroidetes	M	Glycosyl-hydrolase 97 C-terminal, oligomerisation	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	GH97_C,GH97_N,Glyco_hydro_97
TLS2_k127_3826330_2	1267535.KB906767_gene2230	1.521e-16	85.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_3826330_1	530564.Psta_4193	1.124e-16	88.0	COG0433@1|root,COG0433@2|Bacteria,2IY71@203682|Planctomycetes	203682|Planctomycetes	L	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87,PDDEXK_1
TLS2_k127_3827156_5	1336233.JAEH01000071_gene1021	0.0001268	53.0	COG1629@1|root,COG4771@2|Bacteria,1MW4X@1224|Proteobacteria,1RPVY@1236|Gammaproteobacteria,2QABV@267890|Shewanellaceae	1236|Gammaproteobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_3827156_4	3218.PP1S65_113V6.1	1.366e-11	74.0	COG0170@1|root,KOG4453@2759|Eukaryota,37QCU@33090|Viridiplantae,3GCR8@35493|Streptophyta	35493|Streptophyta	K	Phytol kinase	-	-	2.7.1.182,2.7.1.216	ko:K15892,ko:K18678	ko00900,ko01130,map00900,map01130	-	R09849,R10659	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	-
TLS2_k127_3827156_0	1047013.AQSP01000138_gene1020	6.973e-150	489.0	COG0008@1|root,COG0008@2|Bacteria,2NNMZ@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS2_k127_3827156_2	1382359.JIAL01000001_gene2653	2.268e-62	224.0	COG0566@1|root,COG0566@2|Bacteria,3Y3XM@57723|Acidobacteria,2JII0@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS2_k127_3827156_1	1125863.JAFN01000001_gene1651	3.499e-108	379.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
TLS2_k127_3827156_3	204669.Acid345_1394	1.276e-52	193.0	COG2204@1|root,COG2204@2|Bacteria,3Y2J1@57723|Acidobacteria,2JIIE@204432|Acidobacteriia	204432|Acidobacteriia	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_3832426_0	1267535.KB906767_gene4837	6.166e-162	536.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_3844265_0	1121904.ARBP01000013_gene402	6.149e-161	513.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
TLS2_k127_3844265_2	118163.Ple7327_2771	0.0001938	48.0	COG2442@1|root,COG2442@2|Bacteria,1G818@1117|Cyanobacteria,3VK8Y@52604|Pleurocapsales	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
TLS2_k127_3844265_1	383372.Rcas_1636	2.351e-10	61.0	COG2442@1|root,COG2442@2|Bacteria	2|Bacteria	K	InterPro IPR007367	-	-	-	-	-	-	-	-	-	-	-	-	DUF433,MerR_1
TLS2_k127_3847455_0	1122971.BAME01000003_gene438	4.826e-209	656.0	COG1501@1|root,COG1501@2|Bacteria,4NE1H@976|Bacteroidetes,2FPZV@200643|Bacteroidia,22ZMJ@171551|Porphyromonadaceae	976|Bacteroidetes	G	Galactose mutarotase-like	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
TLS2_k127_3847455_1	1047013.AQSP01000088_gene1631	7.769e-153	522.0	COG1629@1|root,COG1629@2|Bacteria,2NS4U@2323|unclassified Bacteria	2|Bacteria	P	PFAM TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_3854628_0	344747.PM8797T_11189	1.626e-98	331.0	COG5434@1|root,COG5434@2|Bacteria,2IX4E@203682|Planctomycetes	203682|Planctomycetes	M	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,Pectate_lyase_3
TLS2_k127_3854628_1	314230.DSM3645_07485	3.56e-71	252.0	COG0673@1|root,COG0673@2|Bacteria,2J216@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_3860211_2	469383.Cwoe_1914	1.734e-11	65.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,4CP86@84995|Rubrobacteria	84995|Rubrobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_3860211_0	97139.C824_02719	9.597e-43	169.0	COG1479@1|root,COG1479@2|Bacteria,1VHC8@1239|Firmicutes,24PSV@186801|Clostridia,36W3S@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function DUF262	-	-	-	-	-	-	-	-	-	-	-	-	DUF262
TLS2_k127_3860211_1	1397696.KK211189_gene1755	2.312e-28	127.0	COG2357@1|root,COG2357@2|Bacteria,1TQ2F@1239|Firmicutes,4HIW3@91061|Bacilli	91061|Bacilli	S	Region found in RelA / SpoT proteins	-	-	-	-	-	-	-	-	-	-	-	-	RelA_SpoT
TLS2_k127_3860211_3	1122221.JHVI01000015_gene1674	4.89e-05	46.0	COG0782@1|root,COG0782@2|Bacteria,1WJEV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TLS2_k127_3861890_2	526222.Desal_3703	1.024e-112	381.0	COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,42PCY@68525|delta/epsilon subdivisions,2WJCR@28221|Deltaproteobacteria,2M8HZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	SMART chemotaxis sensory transducer	-	-	-	ko:K03406,ko:K13487	ko02020,ko02025,ko02030,map02020,map02025,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	Cache_3-Cache_2,HAMP,MCPsignal
TLS2_k127_3861890_4	497964.CfE428DRAFT_2821	1.509e-74	276.0	COG0840@1|root,COG0840@2|Bacteria,46UVU@74201|Verrucomicrobia	74201|Verrucomicrobia	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,HAMP,MCPsignal
TLS2_k127_3861890_7	56110.Oscil6304_1340	4.544e-34	140.0	COG0835@1|root,COG0835@2|Bacteria,1G6T8@1117|Cyanobacteria,1HBU2@1150|Oscillatoriales	1117|Cyanobacteria	NT	Chemotaxis signal transduction protein	-	-	-	ko:K13488	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001	-	-	-	CheW
TLS2_k127_3861890_5	886293.Sinac_4833	1.611e-68	249.0	COG0457@1|root,COG1352@1|root,COG0457@2|Bacteria,COG1352@2|Bacteria,2J2YW@203682|Planctomycetes	203682|Planctomycetes	NT	Methyltransferase, chemotaxis proteins	-	-	-	ko:K13486	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	CheR
TLS2_k127_3861890_6	1122604.JONR01000003_gene1377	1.742e-44	171.0	COG0835@1|root,COG0835@2|Bacteria,1RIUD@1224|Proteobacteria,1SBWJ@1236|Gammaproteobacteria,1X91X@135614|Xanthomonadales	135614|Xanthomonadales	NT	Two component signalling adaptor domain	-	-	-	ko:K13489	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001	-	-	-	CheW
TLS2_k127_3861890_0	526222.Desal_3699	6.224e-217	703.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42QI6@68525|delta/epsilon subdivisions,2WKX0@28221|Deltaproteobacteria,2M95J@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Signal transducing histidine kinase, homodimeric domain	frzE	-	2.7.13.3	ko:K03407,ko:K13490	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00509	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
TLS2_k127_3861890_3	489825.LYNGBM3L_43700	6.968e-103	344.0	COG2201@1|root,COG2201@2|Bacteria,1G1EA@1117|Cyanobacteria,1H8DX@1150|Oscillatoriales	1117|Cyanobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412,ko:K13491	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00509	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
TLS2_k127_3861890_1	1121441.AUCX01000016_gene2382	3.471e-148	479.0	COG2199@1|root,COG2208@1|root,COG2208@2|Bacteria,COG3706@2|Bacteria,1N4K5@1224|Proteobacteria,42RTP@68525|delta/epsilon subdivisions,2WN9M@28221|Deltaproteobacteria,2M9XH@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	PAS_8,Response_reg,SpoIIE
TLS2_k127_3861890_8	1120985.AUMI01000017_gene2583	4.889e-23	104.0	COG1366@1|root,COG1366@2|Bacteria,1VZCA@1239|Firmicutes,4H85Q@909932|Negativicutes	909932|Negativicutes	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
TLS2_k127_3882646_0	595460.RRSWK_00888	2.151e-240	765.0	COG1554@1|root,COG1554@2|Bacteria	2|Bacteria	G	hydrolase, family 65, central catalytic	-	-	3.2.1.51	ko:K15923	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	GH95	-	Glyco_hyd_65N_2
TLS2_k127_3882646_1	204669.Acid345_3039	1.574e-121	406.0	28NTH@1|root,2ZBS4@2|Bacteria,3Y3NN@57723|Acidobacteria,2JIEU@204432|Acidobacteriia	204432|Acidobacteriia	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TLS2_k127_3882646_2	1340493.JNIF01000003_gene4460	2.224e-30	131.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
TLS2_k127_3882646_3	247490.KSU1_B0116	1.331e-28	121.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3884747_2	118161.KB235920_gene5956	7.603e-12	71.0	2CKJ7@1|root,2Z81C@2|Bacteria,1G4KB@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3884747_4	768706.Desor_3765	8.227e-07	55.0	2EFXV@1|root,339Q3@2|Bacteria,1VNHT@1239|Firmicutes,254A7@186801|Clostridia,266ED@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM TOMM propeptide domain	-	-	-	-	-	-	-	-	-	-	-	-	NHase_alpha
TLS2_k127_3884747_1	864051.BurJ1DRAFT_3143	4.529e-39	159.0	COG0037@1|root,COG0037@2|Bacteria,1QNGP@1224|Proteobacteria,2VNQP@28216|Betaproteobacteria,1KN1D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	tRNA processing	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3884747_0	402777.KB235903_gene1644	1.18e-42	169.0	2C5KF@1|root,323ZW@2|Bacteria	2|Bacteria	S	UPF0489 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0489
TLS2_k127_3884747_3	358681.BBR47_46630	3.618e-10	68.0	COG0454@1|root,COG0456@2|Bacteria,1VFWC@1239|Firmicutes,4HNUI@91061|Bacilli,270RI@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_3892890_0	479434.Sthe_1518	7.484e-248	776.0	COG0129@1|root,COG0129@2|Bacteria,2G5QW@200795|Chloroflexi,27XQ0@189775|Thermomicrobia	200795|Chloroflexi	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS2_k127_3892890_1	1166948.JPZL01000001_gene2501	1.088e-73	260.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1XH6C@135619|Oceanospirillales	135619|Oceanospirillales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
TLS2_k127_3893416_2	1267535.KB906767_gene3319	3.157e-52	195.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_3893416_0	1340493.JNIF01000004_gene556	3.359e-182	580.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_3893416_1	1340493.JNIF01000004_gene555	1.13e-127	426.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_3895905_1	1392489.JPOL01000002_gene3032	1.653e-40	153.0	COG4124@1|root,COG4124@2|Bacteria,4NIAN@976|Bacteroidetes,1IEF9@117743|Flavobacteriia,2XK23@283735|Leeuwenhoekiella	976|Bacteroidetes	G	Glycosyl hydrolase family 26	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Big_5,CBM_35,Glyco_hydro_26
TLS2_k127_3895905_3	1459636.NTE_00025	5.615e-39	157.0	arCOG07536@1|root,arCOG07536@2157|Archaea,41SZB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1
TLS2_k127_3895905_0	1121930.AQXG01000002_gene2379	4.866e-195	621.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,4NE2Y@976|Bacteroidetes,1IUW3@117747|Sphingobacteriia	976|Bacteroidetes	P	Rhodanese Homology Domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
TLS2_k127_3895905_2	649638.Trad_0801	3.06e-40	151.0	COG2391@1|root,COG2391@2|Bacteria,1WKEK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM YeeE YedE family (DUF395)	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
TLS2_k127_3898764_1	862751.SACTE_0203	2.114e-105	346.0	COG2085@1|root,COG2085@2|Bacteria,2GJF5@201174|Actinobacteria	201174|Actinobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
TLS2_k127_3898764_0	306281.AJLK01000032_gene1577	2.694e-286	891.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1G1Q1@1117|Cyanobacteria	1117|Cyanobacteria	EU	PFAM Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
TLS2_k127_3898764_2	1379698.RBG1_1C00001G1529	1.92e-18	90.0	COG2304@1|root,COG2304@2|Bacteria,2NPUS@2323|unclassified Bacteria	2|Bacteria	S	IgA Peptidase M64	-	-	-	-	-	-	-	-	-	-	-	-	M64_N,Peptidase_M64
TLS2_k127_3899996_0	1282360.ABAC460_01180	0.0	2086.0	COG0745@1|root,COG1511@1|root,COG2199@1|root,COG2770@1|root,COG5002@1|root,COG0745@2|Bacteria,COG1511@2|Bacteria,COG2770@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1R7HC@1224|Proteobacteria,2TX5S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,Hpt,Response_reg
TLS2_k127_3899996_1	1123508.JH636450_gene7211	8.657e-153	512.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,2IXFD@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg
TLS2_k127_3899996_2	1121935.AQXX01000127_gene1130	1.578e-27	118.0	COG4319@1|root,COG4319@2|Bacteria,1N8AM@1224|Proteobacteria	1224|Proteobacteria	S	ketosteroid isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_3901257_0	555079.Toce_1237	3.041e-212	672.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,42EP2@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
TLS2_k127_3901257_3	1267535.KB906767_gene3291	1.068e-14	78.0	COG1550@1|root,COG1550@2|Bacteria,3Y5B8@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
TLS2_k127_3901257_1	204669.Acid345_4214	3.274e-82	284.0	COG0618@1|root,COG0618@2|Bacteria,3Y2GZ@57723|Acidobacteria,2JI0W@204432|Acidobacteriia	204432|Acidobacteriia	S	DHH family	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TLS2_k127_3901257_2	1242864.D187_006283	2.035e-70	252.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,42MU5@68525|delta/epsilon subdivisions,2WKWY@28221|Deltaproteobacteria,2YVB2@29|Myxococcales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C,TruB_C_2,TruB_N
TLS2_k127_3905581_2	234267.Acid_6565	3.46e-153	493.0	COG3386@1|root,COG3386@2|Bacteria,3Y6WN@57723|Acidobacteria	57723|Acidobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3905581_4	1267535.KB906767_gene1481	1.68e-84	288.0	COG1028@1|root,COG1028@2|Bacteria	1267535.KB906767_gene1481|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3905581_0	1340493.JNIF01000003_gene3063	0.0	1507.0	COG0587@1|root,COG0587@2|Bacteria,3Y2TS@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
TLS2_k127_3905581_1	234267.Acid_0453	1.193e-283	882.0	COG1132@1|root,COG1132@2|Bacteria,3Y2ZR@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane	-	-	-	ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
TLS2_k127_3905581_3	234267.Acid_5257	3.6e-151	488.0	COG0793@1|root,COG0793@2|Bacteria,3Y3A7@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Peptidase S41	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
TLS2_k127_3923484_1	1340493.JNIF01000003_gene3109	2.643e-53	188.0	COG2133@1|root,COG2133@2|Bacteria,3Y3YZ@57723|Acidobacteria	57723|Acidobacteria	G	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS2_k127_3923484_2	1191523.MROS_1563	1.393e-20	102.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0019645,GO:0022900,GO:0022904,GO:0044237,GO:0045333,GO:0055114	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7,Multi-haem_cyto
TLS2_k127_3923484_0	234267.Acid_6302	5.702e-80	278.0	COG1216@1|root,COG1216@2|Bacteria,3Y5FE@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_3938500_3	1121396.KB892924_gene631	3.105e-28	117.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria,2MJ0H@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS2_k127_3938500_1	118168.MC7420_5027	1.319e-134	439.0	COG1052@1|root,COG1052@2|Bacteria,1G028@1117|Cyanobacteria,1H7XD@1150|Oscillatoriales	1117|Cyanobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	ddh	-	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_3938500_0	1121413.JMKT01000009_gene2096	4.471e-157	523.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2M9JU@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
TLS2_k127_3938500_2	761193.Runsl_5463	5.352e-40	151.0	2C5VR@1|root,32CJG@2|Bacteria,4NQV8@976|Bacteroidetes,47V0T@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3939879_6	1121396.KB893012_gene4058	1.033e-44	168.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,42QWD@68525|delta/epsilon subdivisions,2WN14@28221|Deltaproteobacteria,2MJKK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	ycbL	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_3939879_5	317619.ANKN01000051_gene695	8.264e-47	177.0	COG1011@1|root,COG1011@2|Bacteria,1G51I@1117|Cyanobacteria	1117|Cyanobacteria	S	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
TLS2_k127_3939879_3	204536.SULAZ_1484	2.619e-104	346.0	COG2107@1|root,COG2107@2|Bacteria,2G4EE@200783|Aquificae	200783|Aquificae	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
TLS2_k127_3939879_2	497964.CfE428DRAFT_0965	5.939e-116	386.0	COG1082@1|root,COG1082@2|Bacteria,46UT7@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_3939879_1	1267535.KB906767_gene4836	3.927e-171	553.0	COG0457@1|root,COG0457@2|Bacteria	1267535.KB906767_gene4836|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3939879_0	880073.Calab_2026	1.811e-260	816.0	COG0696@1|root,COG0696@2|Bacteria,2NP1Y@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050789,GO:0050793,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	iECSE_1348.ECSE_3895,iJN678.yibO,iJN746.PP_5056	Metalloenzyme,Phosphodiest,iPGM_N
TLS2_k127_3939879_4	1232410.KI421418_gene2147	6.138e-52	191.0	COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,42MGH@68525|delta/epsilon subdivisions,2WK72@28221|Deltaproteobacteria,43S83@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon_1	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS2_k127_3950359_0	1191523.MROS_0752	1.003e-53	208.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,Cellulase,Glyco_hydro_2_C,Glycos_transf_2
TLS2_k127_3952811_0	1499967.BAYZ01000065_gene6084	3.231e-140	459.0	COG0006@1|root,COG0006@2|Bacteria,2NQIC@2323|unclassified Bacteria	2|Bacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
TLS2_k127_3952811_1	368407.Memar_0887	2.932e-136	441.0	COG0596@1|root,arCOG01648@2157|Archaea,2XUZM@28890|Euryarchaeota,2NB9P@224756|Methanomicrobia	224756|Methanomicrobia	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_3952811_3	246197.MXAN_2239	2.668e-79	269.0	COG0431@1|root,COG0431@2|Bacteria,1RH7F@1224|Proteobacteria,43B5W@68525|delta/epsilon subdivisions,2X6JG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS2_k127_3952811_2	1479238.JQMZ01000001_gene1771	1.466e-127	422.0	COG1629@1|root,COG4771@2|Bacteria,1R4PY@1224|Proteobacteria,2U3FF@28211|Alphaproteobacteria,43ZA5@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TLS2_k127_3956191_0	1267533.KB906740_gene137	1.866e-39	156.0	29Y1S@1|root,30JUQ@2|Bacteria,3Y90C@57723|Acidobacteria,2JNWN@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3956191_2	1148.1653043	7.705e-06	56.0	COG0810@1|root,COG0810@2|Bacteria,1GDHQ@1117|Cyanobacteria	1117|Cyanobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3958945_2	518766.Rmar_1268	3.071e-84	285.0	COG0150@1|root,COG0150@2|Bacteria,4NE4E@976|Bacteroidetes,1FIPP@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	F	AIR synthase related protein, C-terminal domain	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_3958945_0	1232410.KI421413_gene539	4.756e-170	547.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,43RZA@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Glutamine amidotransferases class-II	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
TLS2_k127_3958945_3	682795.AciX8_4904	2.261e-51	190.0	COG0632@1|root,COG0632@2|Bacteria,3Y4KI@57723|Acidobacteria,2JJCJ@204432|Acidobacteriia	204432|Acidobacteriia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
TLS2_k127_3958945_1	1122134.KB893650_gene1082	8.086e-142	457.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1XIBE@135619|Oceanospirillales	135619|Oceanospirillales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
TLS2_k127_4005737_0	521674.Plim_2402	1.303e-194	621.0	COG0855@1|root,COG0855@2|Bacteria,2IWVK@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
TLS2_k127_4005737_1	530564.Psta_3550	2.362e-160	525.0	COG0248@1|root,COG0248@2|Bacteria,2IYSV@203682|Planctomycetes	203682|Planctomycetes	FP	Ppx GppA phosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
TLS2_k127_4005737_2	1123242.JH636435_gene2842	2.608e-121	399.0	COG1940@1|root,COG1940@2|Bacteria,2IY6I@203682|Planctomycetes	203682|Planctomycetes	GK	PFAM ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_4005737_4	666685.R2APBS1_2929	2.134e-49	182.0	COG2095@1|root,COG2095@2|Bacteria,1N689@1224|Proteobacteria,1RPV0@1236|Gammaproteobacteria,1X4BK@135614|Xanthomonadales	135614|Xanthomonadales	U	UPF0056 membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	MarC
TLS2_k127_4005737_3	477974.Daud_0439	3.342e-118	389.0	COG0697@1|root,COG0697@2|Bacteria,1UZ6C@1239|Firmicutes,24GY3@186801|Clostridia,262MF@186807|Peptococcaceae	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_4005737_6	1121456.ATVA01000014_gene622	2.781e-09	68.0	2EQI1@1|root,33I41@2|Bacteria,1NBQD@1224|Proteobacteria,43130@68525|delta/epsilon subdivisions,2WWVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4878
TLS2_k127_4008006_4	153721.MYP_2166	5.121e-10	64.0	COG3325@1|root,COG3507@1|root,COG3325@2|Bacteria,COG3507@2|Bacteria,4NEVJ@976|Bacteroidetes,47JBZ@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1,CBM_6,Glyco_hydro_43
TLS2_k127_4008006_0	768704.Desmer_4411	6.17e-104	364.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,261ZQ@186807|Peptococcaceae	186801|Clostridia	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1
TLS2_k127_4008006_2	555779.Dthio_PD1783	5.645e-28	118.0	COG1366@1|root,COG1366@2|Bacteria,1N7D9@1224|Proteobacteria,42V1I@68525|delta/epsilon subdivisions,2WRH0@28221|Deltaproteobacteria,2MD3V@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	transporter antisigma-factor antagonist STAS	-	-	-	ko:K04749,ko:K06378	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS2_k127_4008006_3	555779.Dthio_PD1782	3.265e-26	117.0	COG2172@1|root,COG2172@2|Bacteria,1N9RD@1224|Proteobacteria,42V4M@68525|delta/epsilon subdivisions,2WRKJ@28221|Deltaproteobacteria,2MDM6@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
TLS2_k127_4008006_1	485915.Dret_0342	9.33e-35	141.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42PCY@68525|delta/epsilon subdivisions,2WJCR@28221|Deltaproteobacteria,2M8HZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	SMART chemotaxis sensory transducer	-	-	-	ko:K03406,ko:K13487	ko02020,ko02025,ko02030,map02020,map02025,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	Cache_3-Cache_2,HAMP,MCPsignal
TLS2_k127_401161_3	945713.IALB_0453	3.092e-33	132.0	COG0118@1|root,COG0118@2|Bacteria	2|Bacteria	E	glutamine metabolic process	hisH	GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iECED1_1282.ECED1_2372,iPC815.YPO1545,iYL1228.KPN_02479	GATase
TLS2_k127_401161_1	517418.Ctha_1863	1.088e-61	218.0	COG0131@1|root,COG0131@2|Bacteria,1FDUQ@1090|Chlorobi	1090|Chlorobi	E	PFAM imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
TLS2_k127_401161_0	1121930.AQXG01000017_gene3141	2.517e-90	308.0	COG0079@1|root,COG0079@2|Bacteria,4NEDI@976|Bacteroidetes	976|Bacteroidetes	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_401161_2	28532.XP_010535563.1	4.477e-43	160.0	COG0141@1|root,KOG2697@2759|Eukaryota,37Q6A@33090|Viridiplantae,3GEXV@35493|Streptophyta,3HPHW@3699|Brassicales	35493|Streptophyta	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	HDH	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009314,GO:0009411,GO:0009416,GO:0009507,GO:0009532,GO:0009536,GO:0009555,GO:0009570,GO:0009628,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0032501,GO:0032502,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0048229,GO:0048856,GO:0050896,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
TLS2_k127_4031780_0	555088.DealDRAFT_1894	8.584e-20	91.0	COG3030@1|root,COG3030@2|Bacteria,1VF5Y@1239|Firmicutes,24NG5@186801|Clostridia	186801|Clostridia	S	PFAM FxsA cytoplasmic membrane protein	-	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
TLS2_k127_4031798_2	545695.TREAZ_0221	7.549e-13	70.0	COG0191@1|root,COG0191@2|Bacteria,2J9U8@203691|Spirochaetes	203691|Spirochaetes	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
TLS2_k127_4031798_0	1499967.BAYZ01000077_gene870	5.633e-189	611.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_Isome,Fucose_iso_C
TLS2_k127_4031798_3	234267.Acid_1209	0.0003157	46.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_4031798_1	1340493.JNIF01000004_gene222	7.616e-98	331.0	COG0667@1|root,COG0667@2|Bacteria,3Y3TE@57723|Acidobacteria	2|Bacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_4033629_2	42256.RradSPS_3058	9.879e-65	229.0	COG1503@1|root,COG1503@2|Bacteria	2|Bacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4033629_1	1504672.669784303	7.328e-87	297.0	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria	1224|Proteobacteria	S	Ribonuclease, BN	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_4033629_4	1166018.FAES_3901	2.273e-43	166.0	COG0637@1|root,COG0637@2|Bacteria,4NEEH@976|Bacteroidetes,47XKH@768503|Cytophagia	976|Bacteroidetes	S	HAD-hyrolase-like	pgmB	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS2_k127_4033629_5	273068.TTE0206	3.981e-32	137.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,247K8@186801|Clostridia,42F5F@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Periplasmic binding protein LacI transcriptional regulator	rbsB	-	-	ko:K10439,ko:K17202	ko02010,ko02030,map02010,map02030	M00212,M00590	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.11,3.A.1.2.13,3.A.1.2.16,3.A.1.2.19	-	-	Peripla_BP_4
TLS2_k127_4033629_3	1396141.BATP01000016_gene2778	5.164e-50	190.0	COG0642@1|root,COG2203@1|root,COG4191@1|root,COG4585@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K13040	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HATPase_c_2,HisKA,HisKA_2,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_4033629_0	1122221.JHVI01000003_gene310	2.842e-130	423.0	COG0346@1|root,COG0346@2|Bacteria,1WICF@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_4033785_1	1379270.AUXF01000002_gene1168	9.132e-35	141.0	COG1595@1|root,COG1595@2|Bacteria,1ZT2V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4033785_0	671143.DAMO_2253	5.555e-148	487.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2NNKA@2323|unclassified Bacteria	2|Bacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7,3.1.26.4	ko:K02335,ko:K03469	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
TLS2_k127_4041839_0	1120971.AUCA01000005_gene2323	2.31e-21	109.0	COG4485@1|root,COG5617@1|root,COG4485@2|Bacteria,COG5617@2|Bacteria,1VI49@1239|Firmicutes	1239|Firmicutes	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
TLS2_k127_4044574_0	1144310.PMI07_005586	3.235e-142	469.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria,4BCQJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA,TctB
TLS2_k127_4044574_1	443152.MDG893_15295	2.458e-60	223.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
TLS2_k127_4044574_2	1276756.AUEX01000004_gene2544	4.293e-43	160.0	COG0346@1|root,COG0346@2|Bacteria,1N491@1224|Proteobacteria,2W22E@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_4044574_3	1123060.JONP01000002_gene1007	8.489e-25	109.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2TQT8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS2_k127_404694_3	1123257.AUFV01000009_gene2164	7.944e-36	138.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RMW7@1236|Gammaproteobacteria,1X5NF@135614|Xanthomonadales	135614|Xanthomonadales	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_404694_0	234267.Acid_5500	1.661e-80	281.0	COG0652@1|root,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	HemolysinCabind,Pro_isomerase
TLS2_k127_404694_2	1197906.CAJQ02000040_gene1586	2.037e-69	242.0	COG5530@1|root,COG5530@2|Bacteria,1R6P3@1224|Proteobacteria,2TUPW@28211|Alphaproteobacteria,3JX7R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Predicted integral membrane protein (DUF2270)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2270
TLS2_k127_404694_4	204669.Acid345_1409	5.833e-31	127.0	COG0824@1|root,COG0824@2|Bacteria,3Y4WZ@57723|Acidobacteria,2JJIE@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
TLS2_k127_404694_1	1479237.JMLY01000001_gene2360	1.661e-73	260.0	COG0438@1|root,COG0438@2|Bacteria,1RB3J@1224|Proteobacteria,1RW61@1236|Gammaproteobacteria,469JB@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
TLS2_k127_404694_5	314345.SPV1_01112	5.141e-17	86.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria	1224|Proteobacteria	M	Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A)	msbB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
TLS2_k127_4052072_5	1280688.AUJB01000008_gene540	2.832e-10	65.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia,3NHNV@46205|Pseudobutyrivibrio	186801|Clostridia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TLS2_k127_4052072_3	401526.TcarDRAFT_0524	5.807e-43	167.0	COG0600@1|root,COG0600@2|Bacteria,1UYCY@1239|Firmicutes,4H2M9@909932|Negativicutes	909932|Negativicutes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_4052072_2	794903.OPIT5_05790	1.234e-45	185.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2,OmpA
TLS2_k127_4052072_4	1121013.P873_00390	7.631e-13	78.0	COG1842@1|root,COG1842@2|Bacteria,1NNUD@1224|Proteobacteria	1224|Proteobacteria	KT	PspA/IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
TLS2_k127_4052072_1	926550.CLDAP_34490	2.86e-106	352.0	COG1210@1|root,COG1210@2|Bacteria,2G6XV@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Nucleotidyl transferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_4052072_0	497964.CfE428DRAFT_0194	5.776e-215	677.0	COG4284@1|root,COG4284@2|Bacteria,46SCH@74201|Verrucomicrobia	74201|Verrucomicrobia	H	UTP--glucose-1-phosphate uridylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	UDPGP
TLS2_k127_4052414_2	383372.Rcas_2990	7.588e-127	412.0	COG1331@1|root,COG1331@2|Bacteria,2G5R1@200795|Chloroflexi,374S7@32061|Chloroflexia	32061|Chloroflexia	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
TLS2_k127_4052414_0	926569.ANT_11600	3.441e-161	512.0	COG0191@1|root,COG0191@2|Bacteria	2|Bacteria	G	fructose-bisphosphate aldolase activity	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_4960	F_bP_aldolase
TLS2_k127_4052414_1	1499967.BAYZ01000079_gene882	7.739e-148	477.0	COG2021@1|root,COG2021@2|Bacteria,2NNZR@2323|unclassified Bacteria	2|Bacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_4054334_10	243231.GSU0335	0.0003415	46.0	2BF8R@1|root,3291I@2|Bacteria,1QN8M@1224|Proteobacteria,437DE@68525|delta/epsilon subdivisions,2X2JG@28221|Deltaproteobacteria,43VQ3@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ATP synthase I chain	atpI	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_I
TLS2_k127_4054334_9	335543.Sfum_1607	1.864e-08	59.0	COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,42WTD@68525|delta/epsilon subdivisions,2WSRU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	atpZ	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
TLS2_k127_4054334_4	880072.Desac_2104	4.757e-104	357.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WK06@28221|Deltaproteobacteria,2MSIS@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_4054334_1	234267.Acid_5689	9.084e-192	611.0	COG1008@1|root,COG1008@2|Bacteria,3Y3VX@57723|Acidobacteria	57723|Acidobacteria	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_4054334_0	945713.IALB_1869	4.016e-201	647.0	COG1009@1|root,COG1009@2|Bacteria	2|Bacteria	CP	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
TLS2_k127_4054334_7	234267.Acid_5687	5.529e-36	139.0	COG0713@1|root,COG0713@2|Bacteria,3Y54E@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS2_k127_4054334_6	234267.Acid_5686	1.977e-41	158.0	COG0839@1|root,COG0839@2|Bacteria,3Y5QU@57723|Acidobacteria	57723|Acidobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS2_k127_4054334_5	1267535.KB906767_gene2816	5.347e-51	188.0	COG1143@1|root,COG1143@2|Bacteria,3Y529@57723|Acidobacteria,2JNAS@204432|Acidobacteriia	204432|Acidobacteriia	C	4Fe-4S dicluster domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
TLS2_k127_4054334_3	671143.DAMO_2695	1.997e-109	364.0	COG1005@1|root,COG1005@2|Bacteria,2NNTT@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS2_k127_4054334_2	234267.Acid_5684	8.194e-163	521.0	COG0649@1|root,COG0649@2|Bacteria,3Y3AB@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS2_k127_4054334_8	234267.Acid_5683	2.927e-13	70.0	COG0852@1|root,COG0852@2|Bacteria,3Y5E8@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TLS2_k127_4055868_0	1210884.HG799465_gene11827	6.437e-269	846.0	COG0553@1|root,COG0553@2|Bacteria,2IXFX@203682|Planctomycetes	203682|Planctomycetes	L	COG0553 Superfamily II DNA RNA	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
TLS2_k127_4055868_2	1210884.HG799465_gene11826	6.314e-83	283.0	COG4279@1|root,COG4279@2|Bacteria,2IYXU@203682|Planctomycetes	203682|Planctomycetes	S	SWIM zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
TLS2_k127_4055868_1	1173027.Mic7113_1218	4.423e-100	333.0	COG4826@1|root,COG4826@2|Bacteria,1G29E@1117|Cyanobacteria,1H9A9@1150|Oscillatoriales	1117|Cyanobacteria	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
TLS2_k127_40722_2	886293.Sinac_1999	7.166e-49	178.0	COG5609@1|root,COG5609@2|Bacteria,2J0KX@203682|Planctomycetes	203682|Planctomycetes	S	Uncharacterized conserved protein (DUF2294)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2294
TLS2_k127_40722_4	886293.Sinac_0157	1.919e-13	74.0	297JJ@1|root,2ZUSN@2|Bacteria,2J49K@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_40722_5	159087.Daro_2080	6.982e-07	56.0	COG5487@1|root,COG5487@2|Bacteria,1NE9T@1224|Proteobacteria,2WAN1@28216|Betaproteobacteria,2KXJR@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF1328)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1328
TLS2_k127_40722_3	1504672.669784911	9.907e-28	120.0	COG0642@1|root,COG0784@1|root,COG5278@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5278@2|Bacteria,1NRP8@1224|Proteobacteria,2VIZX@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
TLS2_k127_40722_0	886293.Sinac_1993	1.225e-59	210.0	COG5609@1|root,COG5609@2|Bacteria,2J0WE@203682|Planctomycetes	203682|Planctomycetes	S	Uncharacterized conserved protein (DUF2294)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2294
TLS2_k127_40722_1	1123508.JH636439_gene893	1.81e-56	201.0	COG1052@1|root,COG1052@2|Bacteria,2IYVZ@203682|Planctomycetes	203682|Planctomycetes	CH	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_4074446_1	1000565.METUNv1_01605	6.698e-49	186.0	COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VJV5@28216|Betaproteobacteria,2KW7P@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_4074446_2	665571.STHERM_c15490	6.868e-46	173.0	2E8ZQ@1|root,33397@2|Bacteria,2J942@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4074446_0	472759.Nhal_3295	3.682e-63	225.0	COG1680@1|root,COG1680@2|Bacteria,1NPBV@1224|Proteobacteria,1SQWZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Domain of unknown function (DUF4185)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185
TLS2_k127_4082711_2	234267.Acid_1201	2.811e-47	171.0	COG3591@1|root,COG3591@2|Bacteria,3Y2TU@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
TLS2_k127_4082711_0	518766.Rmar_0040	4.607e-104	344.0	COG2126@1|root,COG2126@2|Bacteria,4NEX1@976|Bacteroidetes	976|Bacteroidetes	J	Pfam Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
TLS2_k127_4082711_3	909663.KI867150_gene153	2.212e-12	71.0	COG3937@1|root,COG3937@2|Bacteria,1Q1WC@1224|Proteobacteria,437II@68525|delta/epsilon subdivisions,2WYKH@28221|Deltaproteobacteria,2MQQX@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	granule-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4082711_1	161156.JQKW01000007_gene785	3.115e-93	318.0	COG0661@1|root,COG0661@2|Bacteria	2|Bacteria	I	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
TLS2_k127_4085354_0	1430331.EP10_07930	0.0	1044.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,4HBER@91061|Bacilli,1WEJE@129337|Geobacillus	91061|Bacilli	E	B12 binding domain	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TLS2_k127_4085354_1	246197.MXAN_1970	6.46e-24	104.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,42SU3@68525|delta/epsilon subdivisions,2WP9X@28221|Deltaproteobacteria,2YVJF@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Methyltransf_11
TLS2_k127_4091063_0	211114.JOEF01000025_gene185	1.188e-105	368.0	COG0491@1|root,COG0491@2|Bacteria,2IBAX@201174|Actinobacteria	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_4091063_3	667014.Thein_2049	5.551e-26	120.0	COG1943@1|root,COG1943@2|Bacteria,2GI5R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
TLS2_k127_4091063_2	1123073.KB899244_gene203	9.561e-35	153.0	COG1874@1|root,COG1874@2|Bacteria,1P0Y5@1224|Proteobacteria,1RZHZ@1236|Gammaproteobacteria,1X4DM@135614|Xanthomonadales	135614|Xanthomonadales	G	glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_35,Glyco_hydro_42
TLS2_k127_4091063_1	1444712.BN1013_01623	8.081e-44	163.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
TLS2_k127_4100335_0	243233.MCA1752	2.086e-313	981.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,1RNRY@1236|Gammaproteobacteria,1XFSK@135618|Methylococcales	135618|Methylococcales	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1
TLS2_k127_4100335_1	443143.GM18_4330	8.563e-177	574.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,42MSV@68525|delta/epsilon subdivisions,2WJ6U@28221|Deltaproteobacteria,43URK@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Penicillin-Binding Protein C-terminus Family	pbp2	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
TLS2_k127_4107204_3	1443125.Z962_03785	2.78e-24	108.0	COG0622@1|root,COG0622@2|Bacteria,1VADJ@1239|Firmicutes,25CNG@186801|Clostridia,36WYB@31979|Clostridiaceae	186801|Clostridia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
TLS2_k127_4107204_2	1382359.JIAL01000001_gene123	2.762e-37	152.0	COG1451@1|root,COG1451@2|Bacteria,3Y2SM@57723|Acidobacteria,2JHKB@204432|Acidobacteriia	204432|Acidobacteriia	S	nucleotide metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4107204_1	1123386.AUIW01000002_gene1271	6.068e-54	192.0	COG2185@1|root,COG2185@2|Bacteria,1WJS8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	TIGRFAM methylmalonyl-CoA mutase C-terminal domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
TLS2_k127_4107204_0	880073.Calab_3014	4.035e-218	686.0	COG1884@1|root,COG1884@2|Bacteria,2NNZ9@2323|unclassified Bacteria	2|Bacteria	I	Methylmalonyl-CoA mutase	icmA	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS2_k127_412587_2	1267535.KB906767_gene5000	1.785e-18	97.0	COG5512@1|root,COG5512@2|Bacteria	2|Bacteria	L	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	Collagen_bind_2,DUF4038,DUF5060,DUF721
TLS2_k127_412587_0	1121396.KB893123_gene1084	1.574e-77	289.0	COG2197@1|root,COG2202@1|root,COG4585@1|root,COG2197@2|Bacteria,COG2202@2|Bacteria,COG4585@2|Bacteria,1NWNJ@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HATPase_c,HTH_3,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3
TLS2_k127_412587_1	1121124.JNIX01000013_gene1550	2.957e-27	117.0	2E902@1|root,3339H@2|Bacteria,1N9U6@1224|Proteobacteria,2UFG4@28211|Alphaproteobacteria,2KH8D@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_414381_4	671143.DAMO_1399	2.386e-39	154.0	COG0352@1|root,COG0352@2|Bacteria,2NPCU@2323|unclassified Bacteria	2|Bacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00788,ko:K14153	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TLS2_k127_414381_0	1121920.AUAU01000018_gene1781	4.935e-183	582.0	COG0439@1|root,COG0439@2|Bacteria,3Y2QZ@57723|Acidobacteria	57723|Acidobacteria	I	acetyl-CoA carboxylase, biotin carboxylase	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TLS2_k127_414381_5	1267534.KB906756_gene26	1.181e-33	135.0	COG0511@1|root,COG0511@2|Bacteria,3Y4W8@57723|Acidobacteria,2JJHQ@204432|Acidobacteriia	204432|Acidobacteriia	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
TLS2_k127_414381_3	1178537.BA1_14470	2.655e-66	240.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,4HAT7@91061|Bacilli,1ZB4P@1386|Bacillus	91061|Bacilli	E	COG0006 Xaa-Pro aminopeptidase	yqhT	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
TLS2_k127_414381_2	204669.Acid345_1473	5.927e-77	274.0	COG4796@1|root,COG4796@2|Bacteria,3Y98D@57723|Acidobacteria	57723|Acidobacteria	U	Secretin and TonB N terminus short domain	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,Secretin,Secretin_N
TLS2_k127_414381_6	1047013.AQSP01000124_gene2678	1.104e-21	104.0	COG3167@1|root,COG3167@2|Bacteria,2NPUF@2323|unclassified Bacteria	2|Bacteria	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
TLS2_k127_414381_7	204669.Acid345_1470	3.003e-08	63.0	COG3166@1|root,COG3166@2|Bacteria	2|Bacteria	NU	PFAM Fimbrial assembly family protein	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
TLS2_k127_414381_1	204669.Acid345_1469	3.189e-90	308.0	COG4972@1|root,COG4972@2|Bacteria,3Y804@57723|Acidobacteria	57723|Acidobacteria	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
TLS2_k127_4144544_3	861299.J421_1409	4.388e-09	64.0	2EV6U@1|root,33NMK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4144544_1	861299.J421_1407	6.349e-37	146.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_4144544_0	861299.J421_5594	8.074e-162	518.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4144544_2	246197.MXAN_1970	4.163e-23	103.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,42SU3@68525|delta/epsilon subdivisions,2WP9X@28221|Deltaproteobacteria,2YVJF@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Methyltransf_11
TLS2_k127_4147716_0	1340493.JNIF01000003_gene1819	3.987e-288	928.0	COG2911@1|root,COG4775@1|root,COG2911@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K07277,ko:K09800	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	AsmA_2,Bac_surface_Ag,DUF748,POTRA,TamB
TLS2_k127_4151192_0	909663.KI867150_gene1871	2.929e-130	426.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,42N63@68525|delta/epsilon subdivisions,2WJPA@28221|Deltaproteobacteria,2MQRM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM nickel-dependent hydrogenase, large subunit	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
TLS2_k127_4151192_5	909663.KI867150_gene1087	2.85e-54	208.0	COG2202@1|root,COG2203@1|root,COG4585@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675,ko:K09684	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko03000	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3,MASE1,PAS,PAS_3,PAS_4,PAS_9,Peripla_BP_3,Response_reg,dCache_2
TLS2_k127_4151192_6	572477.Alvin_2605	4.107e-29	132.0	COG0745@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2203@1|root,COG3829@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1RGZF@1224|Proteobacteria,1S6GG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2202 FOG PAS PAC domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_9
TLS2_k127_4151192_4	1094980.Mpsy_2043	8.595e-62	216.0	COG0784@1|root,arCOG02589@2157|Archaea,2XVUK@28890|Euryarchaeota,2N9UE@224756|Methanomicrobia	224756|Methanomicrobia	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_4151192_3	1237149.C900_01498	1.639e-73	269.0	COG4251@1|root,COG5000@1|root,COG4251@2|Bacteria,COG5000@2|Bacteria,4NDUQ@976|Bacteroidetes,47PTN@768503|Cytophagia	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
TLS2_k127_4151192_1	1234664.AMRO01000077_gene3432	4.013e-130	426.0	COG3876@1|root,COG3876@2|Bacteria,1VRMG@1239|Firmicutes,4HA8F@91061|Bacilli,1WFX8@129337|Geobacillus	91061|Bacilli	S	Protein of unknown function (DUF1343)	ybbC	-	-	-	-	-	-	-	-	-	-	-	DUF1343
TLS2_k127_4151192_2	1123508.JH636439_gene921	1.883e-122	404.0	COG2317@1|root,COG2317@2|Bacteria,2IXSU@203682|Planctomycetes	203682|Planctomycetes	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
TLS2_k127_4154885_5	211165.AJLN01000116_gene3079	1.539e-40	160.0	COG1922@1|root,COG1922@2|Bacteria,1GQMW@1117|Cyanobacteria	1117|Cyanobacteria	M	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4154885_6	768710.DesyoDRAFT_1951	0.0005122	52.0	2CJTW@1|root,33NBH@2|Bacteria,1VM99@1239|Firmicutes,24UVS@186801|Clostridia,26684@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4154885_1	1089553.Tph_c09100	1.995e-103	353.0	COG0407@1|root,COG0407@2|Bacteria,1TRJG@1239|Firmicutes,24B34@186801|Clostridia,42G9W@68295|Thermoanaerobacterales	186801|Clostridia	H	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TLS2_k127_4154885_2	1095747.HMPREF1049_0498	4.934e-89	300.0	COG1540@1|root,COG1540@2|Bacteria,379I4@32066|Fusobacteria	32066|Fusobacteria	S	Belongs to the UPF0271 (lamB) family	-	-	-	ko:K07160	-	-	-	-	ko00000	-	-	-	LamB_YcsF
TLS2_k127_4154885_0	867903.ThesuDRAFT_00908	1.382e-148	483.0	COG1914@1|root,COG1914@2|Bacteria,1TP0Q@1239|Firmicutes,2490P@186801|Clostridia	186801|Clostridia	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
TLS2_k127_4154885_3	1410653.JHVC01000003_gene4082	6.303e-80	273.0	COG2049@1|root,COG2049@2|Bacteria,1TTBZ@1239|Firmicutes,24A35@186801|Clostridia,36EWS@31979|Clostridiaceae	186801|Clostridia	E	Allophanate hydrolase subunit 1	kipI	-	-	ko:K06351	-	-	-	-	ko00000	-	-	-	CT_C_D
TLS2_k127_4154885_4	1487921.DP68_04345	2.463e-75	260.0	COG1984@1|root,COG1984@2|Bacteria,1TR6U@1239|Firmicutes,2485K@186801|Clostridia,36E0F@31979|Clostridiaceae	186801|Clostridia	E	Allophanate hydrolase subunit 2	kipA	-	-	ko:K06350	-	-	-	-	ko00000	-	-	-	CT_A_B
TLS2_k127_4169760_3	649638.Trad_0219	4.92e-21	93.0	COG3546@1|root,COG3546@2|Bacteria,1WI7Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Manganese containing catalase	-	-	-	-	-	-	-	-	-	-	-	-	Mn_catalase
TLS2_k127_4169760_0	1123389.ATXJ01000018_gene976	8.793e-42	157.0	COG1993@1|root,COG1993@2|Bacteria,1WKB2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
TLS2_k127_4169760_2	136993.KB900626_gene3896	1.7e-25	111.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2UBUP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TLS2_k127_4169760_4	616991.JPOO01000003_gene1742	0.0001958	47.0	COG3119@1|root,COG3119@2|Bacteria,4NF1X@976|Bacteroidetes,1HYYH@117743|Flavobacteriia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_4169760_1	402777.KB235903_gene647	7.63e-33	130.0	COG2361@1|root,COG2361@2|Bacteria,1G7XA@1117|Cyanobacteria,1HCYZ@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
TLS2_k127_4173855_1	485913.Krac_10029	1.256e-54	193.0	COG0366@1|root,COG0366@2|Bacteria,2G5NW@200795|Chloroflexi	200795|Chloroflexi	G	SMART alpha amylase catalytic sub domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459,Malt_amylase_C
TLS2_k127_4173855_0	880073.Calab_2261	9.941e-124	417.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,2NNZ0@2323|unclassified Bacteria	2|Bacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefC	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
TLS2_k127_4185097_1	671143.DAMO_0098	4.888e-36	143.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TLS2_k127_4185097_0	373903.Hore_20660	1.494e-107	361.0	COG0153@1|root,COG0153@2|Bacteria,1TPD0@1239|Firmicutes,247U8@186801|Clostridia,3WADG@53433|Halanaerobiales	186801|Clostridia	F	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
TLS2_k127_4185097_2	537972.ABQU01000064_gene1477	1.016e-11	68.0	COG0535@1|root,COG0535@2|Bacteria,1PFFI@1224|Proteobacteria,42XH4@68525|delta/epsilon subdivisions,2YR06@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Radical_SAM,SPASM
TLS2_k127_4196986_0	861299.J421_1620	1.018e-123	402.0	COG3669@1|root,COG3669@2|Bacteria,1ZURK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
TLS2_k127_4196986_1	935557.ATYB01000009_gene809	4.182e-21	102.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,2TYK0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	PAS_3
TLS2_k127_4196986_2	401053.AciPR4_0213	1.643e-13	76.0	COG0745@1|root,COG3942@1|root,COG0745@2|Bacteria,COG3942@2|Bacteria,3Y9C0@57723|Acidobacteria,2JP0M@204432|Acidobacteriia	204432|Acidobacteriia	T	CHAP domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4200145_1	641524.ADICYQ_5367	6.291e-222	699.0	COG2730@1|root,COG2730@2|Bacteria,4NJM9@976|Bacteroidetes	976|Bacteroidetes	G	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
TLS2_k127_4200145_2	1267535.KB906767_gene2720	5.022e-84	299.0	COG0673@1|root,COG0673@2|Bacteria,3Y66I@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_4200145_3	204669.Acid345_4547	7.044e-08	56.0	COG2318@1|root,COG2318@2|Bacteria,3Y5FN@57723|Acidobacteria,2JJTU@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
TLS2_k127_4200145_0	1267535.KB906767_gene5338	1.372e-242	768.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.2.1.23,3.2.1.81	ko:K01190,ko:K01219,ko:K12308	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Cellulase,Glyco_hydro_42,Glyco_hydro_42M
TLS2_k127_4200686_2	880070.Cycma_1902	4.16e-20	97.0	28MHM@1|root,2ZAUH@2|Bacteria,4NKMG@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4200686_0	1500257.JQNM01000001_gene3364	6.153e-122	404.0	COG0520@1|root,COG0520@2|Bacteria,1MXH1@1224|Proteobacteria,2TQUT@28211|Alphaproteobacteria,4BD1H@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_4200686_3	1335760.ASTG01000005_gene1113	7.147e-17	93.0	COG0584@1|root,COG0584@2|Bacteria,1MVWZ@1224|Proteobacteria,2TV4M@28211|Alphaproteobacteria,2K0H8@204457|Sphingomonadales	204457|Sphingomonadales	C	glycerophosphoryl diester phosphodiesterase	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS2_k127_4200686_1	243090.RB4127	8.494e-47	184.0	COG3568@1|root,COG3568@2|Bacteria,2IZ9W@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_42081_0	671143.DAMO_0194	2.474e-111	381.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2NNNP@2323|unclassified Bacteria	2|Bacteria	D	CobQ CobB MinD ParA nucleotide binding domain	ywqD	-	2.7.10.1	ko:K08252,ko:K13661,ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
TLS2_k127_42081_1	1047013.AQSP01000112_gene389	6.217e-49	190.0	COG1596@1|root,COG1596@2|Bacteria,2NPNM@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide export protein	-	-	-	ko:K01991,ko:K20988	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
TLS2_k127_42081_3	156889.Mmc1_2403	3.454e-30	135.0	COG3307@1|root,COG3307@2|Bacteria,1N225@1224|Proteobacteria	1224|Proteobacteria	M	COG3307 Lipid A core - O-antigen ligase and related enzymes	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	Wzy_C
TLS2_k127_42081_6	234267.Acid_5472	3.723e-05	56.0	COG0457@1|root,COG0457@2|Bacteria,3Y3RA@57723|Acidobacteria	57723|Acidobacteria	M	SMART Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
TLS2_k127_42081_5	562970.Btus_3291	2.959e-25	110.0	COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,4HFP8@91061|Bacilli,27A41@186823|Alicyclobacillaceae	91061|Bacilli	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
TLS2_k127_42081_4	204669.Acid345_4135	1.003e-28	118.0	COG1734@1|root,COG1734@2|Bacteria,3Y5PJ@57723|Acidobacteria,2JK2N@204432|Acidobacteriia	204432|Acidobacteriia	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
TLS2_k127_42081_2	555079.Toce_1601	5.056e-35	143.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,42FNR@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM Phosphoribosyltransferase	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
TLS2_k127_4212040_0	234267.Acid_2445	1.449e-118	392.0	COG2234@1|root,COG2234@2|Bacteria,3Y3KE@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
TLS2_k127_4212040_6	1210884.HG799462_gene8125	5.866e-06	54.0	2EH81@1|root,33AZW@2|Bacteria,2J1J2@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4212040_1	880071.Fleli_3574	1.641e-114	389.0	COG2192@1|root,COG2192@2|Bacteria,4NEV9@976|Bacteroidetes,47JR5@768503|Cytophagia	976|Bacteroidetes	O	PFAM Carbamoyltransferase	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TLS2_k127_4212040_4	861299.J421_2552	6.738e-39	153.0	COG0546@1|root,COG0546@2|Bacteria,1ZTK9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
TLS2_k127_4212040_3	65093.PCC7418_2230	9.71e-59	207.0	COG0229@1|root,COG0229@2|Bacteria,1G5S6@1117|Cyanobacteria	1117|Cyanobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
TLS2_k127_4212040_2	326427.Cagg_3457	2.162e-83	285.0	COG3622@1|root,COG3622@2|Bacteria	2|Bacteria	G	hydroxypyruvate isomerase activity	hyi	-	5.3.1.22,5.3.1.35	ko:K01816,ko:K22131	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_4212040_5	1235788.C802_00425	3.718e-16	87.0	COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,2FR1C@200643|Bacteroidia	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_4225797_3	667014.Thein_2063	6.594e-25	110.0	COG4191@1|root,COG4191@2|Bacteria,2GIGP@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_4225797_1	429009.Adeg_0173	5.359e-108	367.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,42J66@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02481,ko:K07714,ko:K10943	ko02020,ko05111,map02020,map05111	M00500,M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_4225797_0	204669.Acid345_1684	8.271e-158	520.0	COG0457@1|root,COG0457@2|Bacteria,3Y2M9@57723|Acidobacteria,2JMD8@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS2_k127_4225797_2	1206720.BAFQ01000296_gene6613	3.494e-84	286.0	COG1801@1|root,COG1801@2|Bacteria,2GMSP@201174|Actinobacteria,4FYDM@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS2_k127_4234671_1	1185876.BN8_04692	2.904e-10	67.0	COG0535@1|root,COG0535@2|Bacteria,4NGWY@976|Bacteroidetes,47K59@768503|Cytophagia	976|Bacteroidetes	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
TLS2_k127_4234671_0	565033.GACE_0916	2.889e-57	215.0	COG1032@1|root,arCOG01356@2157|Archaea,2XU04@28890|Euryarchaeota,245XG@183980|Archaeoglobi	183980|Archaeoglobi	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
TLS2_k127_4238061_4	401053.AciPR4_0941	2.112e-11	71.0	COG2304@1|root,COG2304@2|Bacteria,3Y483@57723|Acidobacteria,2JI1N@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_4238061_1	269799.Gmet_2747	3.076e-64	226.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,42RIC@68525|delta/epsilon subdivisions,2X25I@28221|Deltaproteobacteria,43SXX@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TLS2_k127_4238061_2	290397.Adeh_2564	4.438e-45	169.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,42T2H@68525|delta/epsilon subdivisions,2WRSP@28221|Deltaproteobacteria,2Z31G@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
TLS2_k127_4238061_0	1131269.AQVV01000018_gene1931	1.623e-106	356.0	COG1005@1|root,COG1005@2|Bacteria	2|Bacteria	C	quinone binding	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS2_k127_4238061_3	246194.CHY_0733	3.324e-18	87.0	COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia,42J1I@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	-	-	1.17.1.10,1.6.5.3	ko:K00336,ko:K05299	ko00190,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00134,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
TLS2_k127_4243125_3	760117.JN27_10000	0.0003809	48.0	COG2234@1|root,COG2234@2|Bacteria,1NE83@1224|Proteobacteria,2W7E0@28216|Betaproteobacteria,476C6@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Peptidase family M28	pgcp	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_4243125_0	1408473.JHXO01000001_gene1962	1.679e-135	437.0	COG0667@1|root,COG0667@2|Bacteria,4PPAM@976|Bacteroidetes,2G14T@200643|Bacteroidia	976|Bacteroidetes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_4243125_2	665571.STHERM_c22460	1.401e-67	239.0	COG1136@1|root,COG1136@2|Bacteria,2J5PI@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4243125_1	1131269.AQVV01000009_gene1116	3.506e-85	302.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	lolE-2	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_4243538_1	1033732.CAHI01000030_gene1328	8.398e-10	70.0	28HII@1|root,2Z7TZ@2|Bacteria,4NHR6@976|Bacteroidetes,2FR8B@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4243538_0	661478.OP10G_0821	2.232e-59	211.0	COG3669@1|root,COG3669@2|Bacteria	2|Bacteria	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Fucosidase_C
TLS2_k127_4246910_2	1267535.KB906767_gene3450	1.297e-94	327.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_4246910_0	1219084.AP014508_gene413	5.208e-169	538.0	COG4030@1|root,COG4030@2|Bacteria,2GE3D@200918|Thermotogae	200918|Thermotogae	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
TLS2_k127_4246910_1	204669.Acid345_2574	2.334e-164	547.0	COG1629@1|root,COG4771@2|Bacteria,3Y477@57723|Acidobacteria,2JHX2@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_4246910_3	204669.Acid345_2573	2.774e-19	104.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_4250494_0	1122927.KB895413_gene2084	1.299e-49	200.0	2CHVP@1|root,32DAZ@2|Bacteria,1U06B@1239|Firmicutes,4I9GX@91061|Bacilli,271IJ@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4264143_0	1396141.BATP01000001_gene5350	5.004e-145	471.0	COG0673@1|root,COG0673@2|Bacteria,46S77@74201|Verrucomicrobia,2IU49@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_4264143_1	1122182.KB903839_gene1105	1.224e-18	98.0	COG3595@1|root,COG3595@2|Bacteria,2GJZC@201174|Actinobacteria,4DE6C@85008|Micromonosporales	201174|Actinobacteria	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_4264143_2	204669.Acid345_4526	1.269e-18	94.0	COG1413@1|root,COG5662@1|root,COG1413@2|Bacteria,COG5662@2|Bacteria,3Y2TB@57723|Acidobacteria,2JHKS@204432|Acidobacteriia	204432|Acidobacteriia	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,zf-HC2
TLS2_k127_4267268_0	382464.ABSI01000012_gene1990	7.059e-61	215.0	COG2755@1|root,COG2755@2|Bacteria,46V6J@74201|Verrucomicrobia,2IVPY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_4267268_1	266265.Bxe_B0897	1.686e-05	57.0	COG0810@1|root,COG0810@2|Bacteria,1PED5@1224|Proteobacteria,2W6CX@28216|Betaproteobacteria,1K9CG@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TLS2_k127_4269488_0	1267535.KB906767_gene2100	5.683e-98	335.0	COG0577@1|root,COG0577@2|Bacteria,3Y6QF@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_4272116_4	1197906.CAJQ02000047_gene4077	4.233e-35	136.0	COG2329@1|root,COG2329@2|Bacteria,1N2ZS@1224|Proteobacteria,2UEPY@28211|Alphaproteobacteria,3K08M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4272116_2	483219.LILAB_27660	1.536e-86	289.0	COG0110@1|root,COG0110@2|Bacteria,1RA2T@1224|Proteobacteria,42Z2R@68525|delta/epsilon subdivisions,2WUGF@28221|Deltaproteobacteria,2Z37Y@29|Myxococcales	28221|Deltaproteobacteria	S	Maltose acetyltransferase	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Mac
TLS2_k127_4272116_1	926549.KI421517_gene1771	3.203e-103	346.0	COG2207@1|root,COG2207@2|Bacteria,4NKCH@976|Bacteroidetes,47R08@768503|Cytophagia	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS2_k127_4272116_0	595460.RRSWK_04460	3.83e-109	359.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS2_k127_4272116_3	1267535.KB906767_gene5245	2.31e-75	273.0	COG1629@1|root,COG4771@2|Bacteria,3Y2R5@57723|Acidobacteria,2JIK7@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_4274660_3	448385.sce2753	6.163e-06	58.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,1MWVZ@1224|Proteobacteria,438G1@68525|delta/epsilon subdivisions,2X3QZ@28221|Deltaproteobacteria,2YWVV@29|Myxococcales	28221|Deltaproteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,PEGA,Pkinase,TPR_12
TLS2_k127_4274660_1	1123269.NX02_27645	1.278e-56	211.0	COG2267@1|root,COG3629@1|root,COG2267@2|Bacteria,COG3629@2|Bacteria,1QU9N@1224|Proteobacteria,2TW44@28211|Alphaproteobacteria,2K7FJ@204457|Sphingomonadales	204457|Sphingomonadales	IT	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_4274660_2	113395.AXAI01000006_gene1571	1.594e-08	62.0	COG3631@1|root,COG3631@2|Bacteria,1NGQ1@1224|Proteobacteria,2UJGV@28211|Alphaproteobacteria,3K232@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
TLS2_k127_4274660_0	1382306.JNIM01000001_gene2755	4.073e-79	274.0	COG1335@1|root,COG1335@2|Bacteria,2G8KH@200795|Chloroflexi	200795|Chloroflexi	Q	isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4276743_2	1150474.JQJI01000004_gene436	4.667e-50	183.0	COG1087@1|root,COG1087@2|Bacteria,2GCQI@200918|Thermotogae	200918|Thermotogae	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS2_k127_4276743_4	1227453.C444_12182	1.726e-27	124.0	COG0392@1|root,arCOG00899@2157|Archaea,2Y788@28890|Euryarchaeota,240HY@183963|Halobacteria	183963|Halobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS2_k127_4276743_3	926569.ANT_30190	8.393e-28	117.0	COG5319@1|root,COG5319@2|Bacteria,2GA9G@200795|Chloroflexi	200795|Chloroflexi	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TLS2_k127_4276743_1	926550.CLDAP_10380	1.734e-103	349.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.349	ko:K12994	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_4276743_0	316274.Haur_0234	1.335e-111	371.0	COG0438@1|root,COG0438@2|Bacteria,2G7TE@200795|Chloroflexi,3750Z@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	2.4.1.348	ko:K12995	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_4276748_6	1125863.JAFN01000001_gene2410	5.769e-06	48.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
TLS2_k127_4276748_3	316067.Geob_0472	1.643e-32	129.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42VAT@68525|delta/epsilon subdivisions,2WRE5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS2_k127_4276748_4	1267535.KB906767_gene4286	2.905e-28	120.0	COG0839@1|root,COG0839@2|Bacteria,3Y4I4@57723|Acidobacteria,2JJ8B@204432|Acidobacteriia	204432|Acidobacteriia	C	plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS2_k127_4276748_5	264203.ZMO0738	3.698e-13	73.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria,2K0MM@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
TLS2_k127_4276748_0	316067.Geob_1587	3.643e-118	385.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,42MNC@68525|delta/epsilon subdivisions,2WIUI@28221|Deltaproteobacteria,43TNT@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
TLS2_k127_4276748_1	375286.mma_3363	2.287e-97	330.0	COG0337@1|root,COG0703@1|root,COG0337@2|Bacteria,COG0703@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,4725Y@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
TLS2_k127_4276748_2	751945.Theos_1987	3.095e-40	154.0	COG0500@1|root,COG2226@2|Bacteria,1WIUM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS2_k127_4291223_2	1163617.SCD_n01858	1.918e-48	177.0	COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,2VTC8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
TLS2_k127_4291223_0	243231.GSU0371	3.631e-301	946.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,43T5A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Protein of unknown function (DUF3417)	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
TLS2_k127_4291223_1	867903.ThesuDRAFT_01180	3.441e-60	211.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia	186801|Clostridia	C	aconitate hydratase	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS2_k127_4294956_1	357808.RoseRS_2391	1.32e-37	148.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K20444	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Acyltransferase,MMPL,Methyltransf_13,Methyltransf_14,Methyltransf_23,Methyltransf_31
TLS2_k127_4294956_0	383372.Rcas_3093	7.417e-130	421.0	COG0451@1|root,COG0451@2|Bacteria,2GAMV@200795|Chloroflexi,376SP@32061|Chloroflexia	32061|Chloroflexia	M	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_4295357_2	1183438.GKIL_2517	7.823e-65	233.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TLS2_k127_4295357_0	187272.Mlg_1097	4.252e-212	681.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WW1G@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TLS2_k127_4295357_1	760192.Halhy_3247	1.484e-156	511.0	COG1680@1|root,COG1680@2|Bacteria,4NFUI@976|Bacteroidetes,1INWP@117747|Sphingobacteriia	976|Bacteroidetes	V	COGs COG1680 Beta-lactamase class C and other penicillin binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
TLS2_k127_4295357_4	880073.Calab_0673	1.018e-53	199.0	COG1262@1|root,COG1262@2|Bacteria,2NR84@2323|unclassified Bacteria	2|Bacteria	S	Sulfatase-modifying factor enzyme 1	gldK	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TLS2_k127_4295357_3	452637.Oter_3715	4.869e-60	214.0	COG3132@1|root,COG3132@2|Bacteria,46VIH@74201|Verrucomicrobia,3K85I@414999|Opitutae	414999|Opitutae	S	Belongs to the UPF0502 family	-	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
TLS2_k127_429763_2	439481.Aboo_0529	1.855e-24	104.0	COG2723@1|root,arCOG05412@2157|Archaea,2XV86@28890|Euryarchaeota	28890|Euryarchaeota	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
TLS2_k127_429763_0	697282.Mettu_3896	3.087e-88	316.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1XDVZ@135618|Methylococcales	135618|Methylococcales	F	PFAM Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
TLS2_k127_429763_4	313612.L8106_02152	2.31e-07	63.0	COG2755@1|root,COG2755@2|Bacteria,1G2XP@1117|Cyanobacteria,1H81W@1150|Oscillatoriales	1117|Cyanobacteria	E	SGNH hydrolase-like domain, acetyltransferase AlgX	-	-	-	-	-	-	-	-	-	-	-	-	ALGX
TLS2_k127_429763_3	448385.sce1109	7.236e-08	65.0	COG2244@1|root,COG2244@2|Bacteria,1QT9H@1224|Proteobacteria,439PF@68525|delta/epsilon subdivisions,2X50Z@28221|Deltaproteobacteria,2YZYN@29|Myxococcales	28221|Deltaproteobacteria	S	polysaccharide biosynthetic process	-	-	-	ko:K06409	-	-	-	-	ko00000,ko02000	2.A.66.2.14	-	-	Polysacc_synt
TLS2_k127_429763_1	1173028.ANKO01000030_gene3281	3.631e-59	223.0	COG3379@1|root,COG3379@2|Bacteria,1G44K@1117|Cyanobacteria,1HD9A@1150|Oscillatoriales	1117|Cyanobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_4302709_1	1211813.CAPH01000006_gene1416	3.538e-18	98.0	28MHM@1|root,2ZAUH@2|Bacteria,4NKMG@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4302709_0	411470.RUMGNA_03031	1.074e-104	352.0	COG0006@1|root,COG0006@2|Bacteria,1VS27@1239|Firmicutes,24A4K@186801|Clostridia	186801|Clostridia	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
TLS2_k127_4302709_2	1288963.ADIS_4374	3.532e-09	70.0	28MHM@1|root,2ZAUH@2|Bacteria,4NKMG@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4309_2	502025.Hoch_3922	1.057e-84	290.0	COG1295@1|root,COG1295@2|Bacteria,1R9UY@1224|Proteobacteria,42V9E@68525|delta/epsilon subdivisions,2WRIJ@28221|Deltaproteobacteria,2Z0W1@29|Myxococcales	28221|Deltaproteobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_4309_0	880073.Calab_2195	7.296e-171	551.0	COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
TLS2_k127_4309_1	880073.Calab_2196	9.716e-90	309.0	COG1271@1|root,COG1271@2|Bacteria	2|Bacteria	C	aerobic electron transport chain	-	-	1.10.3.14	ko:K00425,ko:K08738	ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00153,M00595	R10151,R11325	RC00061,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3,3.D.4.6	-	-	Cyt_bd_oxida_I
TLS2_k127_4309_3	1226994.AMZB01000137_gene5451	9.168e-58	205.0	COG1247@1|root,COG1247@2|Bacteria,1QU4K@1224|Proteobacteria,1T2Q1@1236|Gammaproteobacteria,1YKZV@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_4312600_2	525904.Tter_2007	1.352e-48	180.0	2CB42@1|root,2Z7Y3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4312600_0	1353531.AZNX01000006_gene5401	3.786e-139	454.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2TSJV@28211|Alphaproteobacteria,4B9X3@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the RuBisCO large chain family	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
TLS2_k127_4312600_1	1121904.ARBP01000013_gene375	1.065e-115	388.0	COG3395@1|root,COG3395@2|Bacteria,4NFF9@976|Bacteroidetes,47N65@768503|Cytophagia	976|Bacteroidetes	S	Putative nucleotide-binding of sugar-metabolising enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DUF1357_C,DUF1537
TLS2_k127_4312600_3	1232437.KL662075_gene1670	5.424e-18	84.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,42M44@68525|delta/epsilon subdivisions,2WJFW@28221|Deltaproteobacteria,2MIFH@213118|Desulfobacterales	28221|Deltaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS2_k127_4315560_4	1267534.KB906755_gene4691	1.504e-12	68.0	COG0745@1|root,COG0745@2|Bacteria,3Y4D1@57723|Acidobacteria	57723|Acidobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_4315560_1	204669.Acid345_4155	2.89e-25	117.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria,2JIZ4@204432|Acidobacteriia	204432|Acidobacteriia	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_4315560_3	1047013.AQSP01000089_gene1181	1.162e-13	81.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	cyaJ	-	4.6.1.1	ko:K01768,ko:K02483	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	Guanylate_cyc,HTH_18,TPR_16,TPR_19,TPR_2,TPR_8
TLS2_k127_4315560_6	1382356.JQMP01000003_gene2474	5.418e-06	57.0	COG0653@1|root,COG0653@2|Bacteria,2G603@200795|Chloroflexi,27XJU@189775|Thermomicrobia	189775|Thermomicrobia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TLS2_k127_4315560_2	880072.Desac_1019	4.679e-15	83.0	COG4083@1|root,COG4083@2|Bacteria,1RI8D@1224|Proteobacteria,42XUT@68525|delta/epsilon subdivisions,2WSNT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
TLS2_k127_4315560_0	452637.Oter_2210	2.084e-176	567.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.5.1.23	ko:K12349	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00099	R01494	RC00064,RC00328	ko00000,ko00001,ko00002,ko01000	-	-	-	Ceramidase_alk,Ceramidse_alk_C
TLS2_k127_4315560_7	485915.Dret_0440	2.656e-05	46.0	COG0489@1|root,COG1433@1|root,COG0489@2|Bacteria,COG1433@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2WIPG@28221|Deltaproteobacteria,2M7XI@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	Nitro_FeMo-Co,ParA
TLS2_k127_4316493_3	886293.Sinac_3762	7.329e-32	129.0	COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,2IZ1I@203682|Planctomycetes	203682|Planctomycetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,PAS_4
TLS2_k127_4316493_1	1267534.KB906754_gene3421	1.091e-102	346.0	COG0535@1|root,COG0535@2|Bacteria,3Y3TY@57723|Acidobacteria,2JHZQ@204432|Acidobacteriia	204432|Acidobacteriia	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
TLS2_k127_4316493_0	243231.GSU0470	5.661e-129	426.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43UCF@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_4316493_2	573.JG24_26925	3.639e-34	139.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RSI4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Member of the two-component regulatory system ZraS ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium	zraS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010288,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071284,GO:0071294,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,sCache_3_2
TLS2_k127_4319649_1	1267535.KB906767_gene5044	1.663e-80	274.0	COG4221@1|root,COG4221@2|Bacteria,3Y4DX@57723|Acidobacteria	57723|Acidobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_4319649_0	234267.Acid_2707	8.35e-183	580.0	COG0542@1|root,COG0542@2|Bacteria,3Y463@57723|Acidobacteria	57723|Acidobacteria	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
TLS2_k127_4319649_2	243090.RB3251	7.981e-54	198.0	COG2199@1|root,COG5001@1|root,COG3706@2|Bacteria,COG5001@2|Bacteria,2IY4F@203682|Planctomycetes	203682|Planctomycetes	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,PAS_9,Response_reg
TLS2_k127_4324348_1	1122176.KB903556_gene4071	3.192e-52	196.0	COG0535@1|root,COG0535@2|Bacteria,4NGWY@976|Bacteroidetes,1IWI9@117747|Sphingobacteriia	976|Bacteroidetes	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
TLS2_k127_4324348_0	340099.Teth39_0231	6.578e-245	786.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
TLS2_k127_4324348_2	1278073.MYSTI_03754	6.486e-05	53.0	COG0642@1|root,COG2205@2|Bacteria,1QX6V@1224|Proteobacteria,42YJF@68525|delta/epsilon subdivisions,2WUEZ@28221|Deltaproteobacteria,2YUQC@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
TLS2_k127_4333878_3	1385511.N783_00430	2.022e-13	72.0	28H7K@1|root,2Z7JT@2|Bacteria,1UPH1@1239|Firmicutes,4HE88@91061|Bacilli	91061|Bacilli	P	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system	kdgT	-	-	ko:K02526	-	-	-	-	ko00000,ko02000	2.A.10.1	-	-	KdgT
TLS2_k127_4333878_1	234267.Acid_5007	5.395e-45	167.0	COG2764@1|root,COG2764@2|Bacteria	2|Bacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_4333878_0	869210.Marky_1931	2.632e-205	647.0	COG0277@1|root,COG0277@2|Bacteria,1WKVA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_4333878_2	1121939.L861_22705	1.198e-22	99.0	2CZ4M@1|root,32T5I@2|Bacteria,1N344@1224|Proteobacteria,1SRM5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_433819_1	278957.ABEA03000186_gene1557	2.488e-75	256.0	COG0306@1|root,COG0306@2|Bacteria,46SDP@74201|Verrucomicrobia,3K7HD@414999|Opitutae	414999|Opitutae	P	phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
TLS2_k127_433819_0	1408473.JHXO01000004_gene181	4.723e-151	487.0	COG4299@1|root,COG4299@2|Bacteria,4NH8T@976|Bacteroidetes	976|Bacteroidetes	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF5009
TLS2_k127_433819_2	268407.PWYN_27255	2.955e-11	71.0	COG3881@1|root,COG3881@2|Bacteria,1VEG9@1239|Firmicutes,4HPBU@91061|Bacilli,26TVI@186822|Paenibacillaceae	91061|Bacilli	S	Photosystem reaction center subunit H	yrrD	-	-	-	-	-	-	-	-	-	-	-	PRC
TLS2_k127_4344327_2	1267535.KB906767_gene5183	9.743e-26	111.0	COG0802@1|root,COG0802@2|Bacteria,3Y4WF@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Uncharacterised protein family UPF0079, ATPase	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
TLS2_k127_4344327_0	671143.DAMO_1556	2.567e-120	406.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2NNR2@2323|unclassified Bacteria	2|Bacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
TLS2_k127_4344327_1	234267.Acid_3254	8.32e-53	192.0	COG4783@1|root,COG4783@2|Bacteria,3Y3GF@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase M48 Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS2_k127_4366033_2	682795.AciX8_2823	3.893e-22	100.0	COG1802@1|root,COG1802@2|Bacteria,3Y7UB@57723|Acidobacteria,2JMZ9@204432|Acidobacteriia	204432|Acidobacteriia	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_4366033_0	1382306.JNIM01000001_gene620	2.291e-174	559.0	COG1012@1|root,COG1012@2|Bacteria	2|Bacteria	C	belongs to the aldehyde dehydrogenase family	yneI	GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0032787,GO:0034641,GO:0042133,GO:0042135,GO:0042402,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097164,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.2.1.16,1.2.1.20,1.2.1.24,1.2.1.79	ko:K00135,ko:K08324	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	iECUMN_1333.ECUMN_1793	Aldedh
TLS2_k127_4366033_1	1128421.JAGA01000001_gene2449	1.612e-135	452.0	COG3842@1|root,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran,TOBE_2,TOBE_3
TLS2_k127_4366033_3	1382359.JIAL01000001_gene1846	7.995e-20	99.0	COG0457@1|root,COG0457@2|Bacteria,3Y5A8@57723|Acidobacteria,2JNC1@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
TLS2_k127_4376800_4	926569.ANT_20320	1.648e-64	228.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS2_k127_4376800_0	926550.CLDAP_27890	1.83e-118	392.0	COG0438@1|root,COG0438@2|Bacteria,2G7W9@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4
TLS2_k127_4376800_2	926550.CLDAP_27900	2.857e-115	386.0	COG0438@1|root,COG0438@2|Bacteria,2G60E@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
TLS2_k127_4376800_1	926569.ANT_20350	5.191e-118	395.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_4376800_3	926550.CLDAP_36360	2.451e-88	306.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2G67F@200795|Chloroflexi	200795|Chloroflexi	M	PFAM sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS2_k127_4387483_0	234267.Acid_3565	1.288e-132	451.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	ko:K13735,ko:K20276	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001	-	-	-	ASH,CarboxypepD_reg,DUF11,FlgD_ig,HYR,Laminin_G_3,Plug,TonB_dep_Rec
TLS2_k127_4392637_1	909663.KI867150_gene2186	7.564e-20	96.0	COG1413@1|root,COG1413@2|Bacteria,1PX86@1224|Proteobacteria,431NW@68525|delta/epsilon subdivisions,2WWZV@28221|Deltaproteobacteria,2MSH9@213462|Syntrophobacterales	2|Bacteria	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT,HEAT_2,HEAT_PBS
TLS2_k127_4392637_0	1121904.ARBP01000021_gene3618	3.027e-92	311.0	COG0684@1|root,COG0684@2|Bacteria,4NF3M@976|Bacteroidetes,47W9V@768503|Cytophagia	976|Bacteroidetes	H	Pfam:Methyltransf_6	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
TLS2_k127_4392637_2	1267535.KB906767_gene1112	1.177e-10	62.0	COG0492@1|root,COG0492@2|Bacteria,3Y2W6@57723|Acidobacteria,2JIIK@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_4395995_1	1382359.JIAL01000001_gene74	1.561e-85	298.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Dioxygenase_C
TLS2_k127_4395995_2	234267.Acid_0031	2.162e-61	219.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CBM_6,FGE-sulfatase,Metallophos,NACHT,NPCBM,Pkinase
TLS2_k127_4395995_4	234267.Acid_0032	4.148e-25	112.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	petC	-	1.10.9.1	ko:K02636	ko00195,ko01100,map00195,map01100	M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
TLS2_k127_4395995_0	1121904.ARBP01000011_gene1574	1.495e-119	405.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CHU_C,PKD,fn3
TLS2_k127_4395995_3	1121904.ARBP01000003_gene6151	3.336e-43	178.0	28KJN@1|root,2ZA4P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4417872_0	1267535.KB906767_gene3945	5.386e-203	655.0	COG1874@1|root,COG1874@2|Bacteria,3Y2WD@57723|Acidobacteria,2JIC9@204432|Acidobacteriia	204432|Acidobacteriia	G	Beta-galactosidase trimerisation domain	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
TLS2_k127_4417872_1	105425.BBPL01000045_gene3219	1.942e-175	559.0	COG1032@1|root,COG1032@2|Bacteria,2GZU1@201174|Actinobacteria,2NI0T@228398|Streptacidiphilus	201174|Actinobacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4417872_2	204669.Acid345_0708	1.07e-69	241.0	COG1100@1|root,COG1100@2|Bacteria,3Y7CQ@57723|Acidobacteria	57723|Acidobacteria	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
TLS2_k127_4417872_3	1121920.AUAU01000008_gene1553	3.687e-14	78.0	COG2018@1|root,COG2018@2|Bacteria	2|Bacteria	K	Roadblock/LC7 domain	mglB	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
TLS2_k127_4417872_4	2423.NA23_0205210	0.000368	49.0	COG0457@1|root,COG0457@2|Bacteria	2423.NA23_0205210|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4418764_5	373903.Hore_20320	6.546e-20	95.0	COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,24864@186801|Clostridia,3WAEH@53433|Halanaerobiales	186801|Clostridia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
TLS2_k127_4418764_3	1122605.KB893637_gene3225	1.822e-31	132.0	COG1070@1|root,COG1070@2|Bacteria,4NFBG@976|Bacteroidetes,1IPCF@117747|Sphingobacteriia	976|Bacteroidetes	G	Belongs to the FGGY kinase family	-	-	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	-	R01737	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
TLS2_k127_4418764_0	1122605.KB893637_gene3224	1.633e-112	379.0	COG3356@1|root,COG3356@2|Bacteria,4NJPV@976|Bacteroidetes,1IX82@117747|Sphingobacteriia	976|Bacteroidetes	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
TLS2_k127_4418764_1	1122605.KB893637_gene3222	6.395e-111	371.0	COG1820@1|root,COG1820@2|Bacteria,4NJ35@976|Bacteroidetes,1IPWP@117747|Sphingobacteriia	976|Bacteroidetes	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS2_k127_4418764_4	867903.ThesuDRAFT_00857	1.825e-30	130.0	COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,25C4D@186801|Clostridia,3WDKQ@538999|Clostridiales incertae sedis	186801|Clostridia	K	PFAM Bacterial regulatory proteins, deoR family	-	-	-	ko:K02081,ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
TLS2_k127_4418764_2	1122605.KB893637_gene3221	1.13e-100	339.0	COG0160@1|root,COG0160@2|Bacteria,4NIHH@976|Bacteroidetes,1IWIQ@117747|Sphingobacteriia	976|Bacteroidetes	E	COGs COG0160 4-aminobutyrate aminotransferase and related aminotransferase	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_4422810_0	335543.Sfum_4007	5.234e-137	461.0	COG1572@1|root,COG1572@2|Bacteria,1N1AP@1224|Proteobacteria	1224|Proteobacteria	S	Peptidase family C25	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25
TLS2_k127_4422810_1	335543.Sfum_4009	2.601e-56	205.0	COG0535@1|root,COG0535@2|Bacteria,1MYFX@1224|Proteobacteria,42SB0@68525|delta/epsilon subdivisions,2WPF4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
TLS2_k127_4426850_1	452637.Oter_0018	1.059e-31	131.0	COG0479@1|root,COG0479@2|Bacteria	2|Bacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
TLS2_k127_4426850_0	1123368.AUIS01000006_gene569	1.289e-118	400.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,Cytochrome_CBB3,GSDH,PSCyt3,PSD3,PSD4,PSD5,SGL
TLS2_k127_4432952_0	1122605.KB893637_gene3246	7.824e-33	143.0	COG4409@1|root,COG4409@2|Bacteria,4P66K@976|Bacteroidetes,1IZ75@117747|Sphingobacteriia	976|Bacteroidetes	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_4432952_1	344747.PM8797T_22903	6.792e-19	97.0	COG1621@1|root,COG1621@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 32 family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,HTH_18
TLS2_k127_4455799_3	1429851.X548_08420	9.764e-05	46.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RSDZ@1236|Gammaproteobacteria,1X3Y5@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_4455799_0	1379698.RBG1_1C00001G0696	4.435e-114	381.0	COG1301@1|root,COG1301@2|Bacteria,2NP6X@2323|unclassified Bacteria	2|Bacteria	U	Sodium:dicarboxylate symporter family	gltP	-	-	ko:K03309	-	-	-	-	ko00000	2.A.23	-	-	SDF
TLS2_k127_4455799_2	96561.Dole_2867	1.424e-21	104.0	2EJPK@1|root,33DEE@2|Bacteria,1NF1Y@1224|Proteobacteria,42VT1@68525|delta/epsilon subdivisions,2WS2W@28221|Deltaproteobacteria,2MPD5@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4455799_1	1476583.DEIPH_ctg011orf0130	1.7e-65	226.0	COG0463@1|root,COG0463@2|Bacteria,1WNDK@1297|Deinococcus-Thermus	2|Bacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_4456092_2	338966.Ppro_2405	2.977e-27	112.0	COG1722@1|root,COG1722@2|Bacteria,1Q1MM@1224|Proteobacteria,42X37@68525|delta/epsilon subdivisions,2WSNI@28221|Deltaproteobacteria,43VHI@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
TLS2_k127_4456092_1	338966.Ppro_2404	7.12e-151	481.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,42NPN@68525|delta/epsilon subdivisions,2WIY4@28221|Deltaproteobacteria,43UK9@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Polyprenyl synthetase	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00795,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_4456092_0	338966.Ppro_2403	3.426e-291	901.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria,43UFS@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
TLS2_k127_445728_0	289376.THEYE_A0955	7.299e-141	459.0	COG3876@1|root,COG3876@2|Bacteria	2|Bacteria	G	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
TLS2_k127_445728_1	204669.Acid345_3342	4.254e-54	199.0	COG1427@1|root,COG1427@2|Bacteria,3Y3PU@57723|Acidobacteria,2JIWB@204432|Acidobacteriia	204432|Acidobacteriia	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
TLS2_k127_4463752_3	880073.Calab_0806	4.511e-130	422.0	COG1351@1|root,COG1351@2|Bacteria,2NPQ2@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
TLS2_k127_4463752_4	153721.MYP_1907	9.245e-129	419.0	COG0823@1|root,COG0823@2|Bacteria,4NG4S@976|Bacteroidetes,47KMG@768503|Cytophagia	976|Bacteroidetes	U	WD40-like Beta Propeller Repeat	tolB3	-	-	-	-	-	-	-	-	-	-	-	PD40
TLS2_k127_4463752_7	1340493.JNIF01000004_gene762	3.219e-79	276.0	COG1879@1|root,COG1879@2|Bacteria,3Y872@57723|Acidobacteria	57723|Acidobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TLS2_k127_4463752_0	546414.Deide_12150	2.139e-180	574.0	COG0821@1|root,COG0821@2|Bacteria,1WJ94@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TLS2_k127_4463752_6	118166.JH976537_gene2622	3.579e-102	342.0	COG1131@1|root,COG1131@2|Bacteria,1G11U@1117|Cyanobacteria,1H8ET@1150|Oscillatoriales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4463752_8	880073.Calab_2471	2.236e-58	213.0	COG1277@1|root,COG1277@2|Bacteria,2NPGK@2323|unclassified Bacteria	2|Bacteria	S	ABC-2 family transporter protein	yxlG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
TLS2_k127_4463752_5	880073.Calab_2472	7.331e-108	369.0	COG3225@1|root,COG3225@2|Bacteria,2NNVN@2323|unclassified Bacteria	2|Bacteria	N	ABC-type uncharacterized transport system	gldG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC_transp_aux
TLS2_k127_4463752_9	111780.Sta7437_0467	9.335e-12	77.0	COG3170@1|root,COG3170@2|Bacteria,1G6DU@1117|Cyanobacteria,3VJYM@52604|Pleurocapsales	1117|Cyanobacteria	NU	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
TLS2_k127_4463752_2	1382359.JIAL01000001_gene86	8.347e-131	428.0	COG0438@1|root,COG0438@2|Bacteria,3Y3CI@57723|Acidobacteria,2JKK7@204432|Acidobacteriia	204432|Acidobacteriia	M	glycosyl transferase group 1	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_4463752_1	1121904.ARBP01000013_gene402	7.055e-170	543.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
TLS2_k127_4477549_0	1340493.JNIF01000003_gene3565	1.522e-271	853.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_4484291_0	1121904.ARBP01000013_gene373	4.468e-170	544.0	COG2730@1|root,COG2730@2|Bacteria,4P1NI@976|Bacteroidetes,47TT8@768503|Cytophagia	976|Bacteroidetes	G	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038,DUF5060
TLS2_k127_4484291_1	861299.J421_5620	7.121e-16	82.0	28J3W@1|root,2Z900@2|Bacteria	2|Bacteria	S	NIPSNAP family containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
TLS2_k127_4485445_1	1380391.JIAS01000012_gene4526	2.762e-116	381.0	COG4948@1|root,COG4948@2|Bacteria,1R63G@1224|Proteobacteria,2TT3A@28211|Alphaproteobacteria,2JW8D@204441|Rhodospirillales	204441|Rhodospirillales	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_4485445_0	926550.CLDAP_34570	4.018e-158	507.0	COG0673@1|root,COG0673@2|Bacteria,2G7YW@200795|Chloroflexi	200795|Chloroflexi	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4485445_2	575540.Isop_0756	7.163e-97	323.0	COG0274@1|root,COG0274@2|Bacteria,2IWY0@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS2_k127_4485445_3	243231.GSU1614	1.636e-17	88.0	COG1832@1|root,COG1832@2|Bacteria,1NJW8@1224|Proteobacteria,42WY1@68525|delta/epsilon subdivisions,2X9YF@28221|Deltaproteobacteria,43V09@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2
TLS2_k127_448881_0	234267.Acid_2214	1.838e-61	232.0	COG0577@1|root,COG0577@2|Bacteria,3Y6B8@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_4490028_0	1267535.KB906767_gene1369	8.382e-116	391.0	COG2982@1|root,COG2982@2|Bacteria,3Y2ZX@57723|Acidobacteria,2JIF6@204432|Acidobacteriia	204432|Acidobacteriia	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
TLS2_k127_4490028_1	1267535.KB906767_gene4699	6.145e-12	67.0	COG4447@1|root,COG4447@2|Bacteria,3Y2MX@57723|Acidobacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
TLS2_k127_4500652_1	290397.Adeh_0234	9.299e-93	325.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,42Q14@68525|delta/epsilon subdivisions,2WJ8C@28221|Deltaproteobacteria,2YX9F@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
TLS2_k127_4500652_0	926550.CLDAP_13620	6.455e-94	314.0	COG1063@1|root,COG1063@2|Bacteria,2G7MF@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Alcohol dehydrogenase GroES domain protein	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
TLS2_k127_4502861_1	472759.Nhal_0320	4.455e-28	116.0	COG2337@1|root,COG2337@2|Bacteria,1N0JV@1224|Proteobacteria,1S75C@1236|Gammaproteobacteria,1X1JV@135613|Chromatiales	135613|Chromatiales	L	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
TLS2_k127_4502861_0	756272.Plabr_0954	3.997e-82	286.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	DUF3701,Phage_int_SAM_1,Phage_integrase
TLS2_k127_4502861_2	272134.KB731324_gene3210	2.201e-26	112.0	COG3744@1|root,COG3744@2|Bacteria,1G89C@1117|Cyanobacteria,1HCPH@1150|Oscillatoriales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_4502861_3	743718.Isova_0324	2.488e-11	66.0	COG4118@1|root,COG4118@2|Bacteria,2HRVW@201174|Actinobacteria,4F5X5@85017|Promicromonosporaceae	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS2_k127_4505788_2	379066.GAU_0644	2.898e-126	428.0	COG5009@1|root,COG5009@2|Bacteria,1ZT3R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS2_k127_4505788_1	1121011.AUCB01000042_gene786	2.712e-157	507.0	COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,1IG0A@117743|Flavobacteriia,23IC9@178469|Arenibacter	976|Bacteroidetes	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,F5_F8_type_C
TLS2_k127_4505788_4	1121091.AUMP01000020_gene3709	7.475e-05	49.0	COG2120@1|root,COG2120@2|Bacteria,1UYPV@1239|Firmicutes,4HCT3@91061|Bacilli	91061|Bacilli	M	NPCBM-associated, NEW3 domain of alpha-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc,PIG-L
TLS2_k127_4505788_0	748247.AZKH_2015	3.478e-189	602.0	COG1858@1|root,COG1858@2|Bacteria,1N4E1@1224|Proteobacteria,2VVJQ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
TLS2_k127_4505788_3	1150469.RSPPHO_02592	1.029e-33	146.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,2JQFN@204441|Rhodospirillales	204441|Rhodospirillales	M	penicillin-binding protein 1A	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
TLS2_k127_4506214_1	483219.LILAB_02805	2.326e-112	372.0	COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,42NRH@68525|delta/epsilon subdivisions,2WNIB@28221|Deltaproteobacteria,2YV7G@29|Myxococcales	28221|Deltaproteobacteria	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
TLS2_k127_4506214_2	1121428.DESHY_60239___1	1.669e-85	288.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,24HDS@186801|Clostridia,260SB@186807|Peptococcaceae	186801|Clostridia	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
TLS2_k127_4506214_8	1267533.KB906740_gene277	1.139e-06	57.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797,ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
TLS2_k127_4506214_9	679937.Bcop_0132	0.0006584	46.0	COG0457@1|root,COG0457@2|Bacteria,4NMG2@976|Bacteroidetes,2FP23@200643|Bacteroidia,4AMJ7@815|Bacteroidaceae	976|Bacteroidetes	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_8
TLS2_k127_4506214_3	1280390.CBQR020000164_gene4381	2.989e-59	219.0	COG1680@1|root,COG1680@2|Bacteria,1TR9E@1239|Firmicutes,4HER8@91061|Bacilli,26S99@186822|Paenibacillaceae	91061|Bacilli	V	Beta-lactamase class C and other penicillin binding	M1-750	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_4506214_7	1267535.KB906767_gene2388	2.308e-08	63.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
TLS2_k127_4506214_4	278963.ATWD01000002_gene215	8.485e-53	209.0	COG3275@1|root,COG3275@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	lytS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K02478,ko:K07704	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	iECW_1372.ECW_m2327,iWFL_1372.ECW_m2327	5TM-5TMR_LYT,ECF_trnsprt,GAF_3,HATPase_c,His_kinase
TLS2_k127_4506214_5	452637.Oter_1527	7.856e-43	166.0	COG3279@1|root,COG3279@2|Bacteria,46X3T@74201|Verrucomicrobia,3K9Q8@414999|Opitutae	414999|Opitutae	K	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
TLS2_k127_4506214_0	1267534.KB906755_gene4142	4.706e-189	619.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_4506214_6	631362.Thi970DRAFT_03056	1.131e-35	138.0	COG0613@1|root,COG1196@1|root,COG0613@2|Bacteria,COG1196@2|Bacteria,1PRIC@1224|Proteobacteria,1RZ3J@1236|Gammaproteobacteria,1WZ3S@135613|Chromatiales	135613|Chromatiales	D	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23
TLS2_k127_45093_0	314230.DSM3645_13885	7.732e-162	518.0	COG4946@1|root,COG4946@2|Bacteria,2IY4Z@203682|Planctomycetes	203682|Planctomycetes	M	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_45093_2	1121422.AUMW01000024_gene240	1.346e-29	126.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,262RV@186807|Peptococcaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_45093_1	742726.HMPREF9448_01035	6.617e-56	207.0	COG1874@1|root,COG1874@2|Bacteria,4PNM8@976|Bacteroidetes,2G105@200643|Bacteroidia,22YWU@171551|Porphyromonadaceae	976|Bacteroidetes	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_451675_0	926550.CLDAP_18760	9.839e-113	369.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,2G7JD@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
TLS2_k127_451675_2	452863.Achl_1710	1.609e-09	68.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	rhaR_1	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
TLS2_k127_451675_1	537013.CLOSTMETH_03274	6.922e-15	82.0	COG2169@1|root,COG2169@2|Bacteria,1UINQ@1239|Firmicutes,24D3G@186801|Clostridia	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
TLS2_k127_4517142_1	1267534.KB906756_gene683	4.916e-114	380.0	COG1222@1|root,COG1222@2|Bacteria	2|Bacteria	O	protein catabolic process	-	-	-	ko:K03420,ko:K13525,ko:K17681	ko03050,ko04141,ko05134,map03050,map04141,map05134	M00343,M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko03029,ko03051,ko04131,ko04147	3.A.16.1	-	-	AAA
TLS2_k127_4517142_3	675814.VIC_000067	8.717e-07	57.0	COG3678@1|root,COG3678@2|Bacteria,1RBDH@1224|Proteobacteria,1S2DT@1236|Gammaproteobacteria,1XWIC@135623|Vibrionales	135623|Vibrionales	NPTU	COG3678 P pilus assembly Cpx signaling pathway, periplasmic inhibitor zinc-resistance associated protein	cpxP	-	-	ko:K06006	-	-	-	-	ko00000,ko03110	-	-	-	LTXXQ
TLS2_k127_4517142_0	479434.Sthe_2324	6.049e-117	385.0	COG0407@1|root,COG0407@2|Bacteria,2G5NU@200795|Chloroflexi,27XWH@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS2_k127_4517142_2	479434.Sthe_2326	1.558e-86	297.0	COG0276@1|root,COG0276@2|Bacteria,2G6A2@200795|Chloroflexi,27XJN@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
TLS2_k127_4525817_3	1382359.JIAL01000001_gene1086	7.262e-18	85.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria,2JI1J@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
TLS2_k127_4525817_2	234267.Acid_6219	1.535e-47	183.0	COG2304@1|root,COG2304@2|Bacteria,3Y483@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_4525817_0	1047013.AQSP01000123_gene1522	5.237e-121	416.0	COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
TLS2_k127_4525817_1	234267.Acid_7764	1.801e-119	395.0	COG0673@1|root,COG0673@2|Bacteria,3Y4BF@57723|Acidobacteria	57723|Acidobacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_4525817_4	913865.DOT_4468	1.213e-05	51.0	2EGD6@1|root,33A4Z@2|Bacteria,1VJDX@1239|Firmicutes,24X3W@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
TLS2_k127_4528035_5	944480.ATUV01000002_gene24	9.225e-19	92.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,42NAR@68525|delta/epsilon subdivisions,2WQB1@28221|Deltaproteobacteria,2M6PV@213113|Desulfurellales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3353	Complex1_30kDa
TLS2_k127_4528035_3	1121920.AUAU01000016_gene1317	4.386e-71	244.0	COG0377@1|root,COG0377@2|Bacteria,3Y3JS@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TLS2_k127_4528035_4	671143.DAMO_2700	1.048e-37	145.0	COG0838@1|root,COG0838@2|Bacteria,2NPTW@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TLS2_k127_4528035_1	269799.Gmet_1431	3.861e-153	488.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42MI8@68525|delta/epsilon subdivisions,2WJDT@28221|Deltaproteobacteria,43SIZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM NAD-dependent epimerase dehydratase	uxs	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_4528035_2	1255043.TVNIR_3850	4.933e-111	367.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1WWNR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2,5.1.3.5	ko:K01784,ko:K12448	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01473,R02984	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS2_k127_4528035_0	682795.AciX8_2085	2.222e-193	615.0	COG0556@1|root,COG0556@2|Bacteria,3Y31K@57723|Acidobacteria,2JHY9@204432|Acidobacteriia	204432|Acidobacteriia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
TLS2_k127_4540705_1	880073.Calab_0920	3.216e-76	262.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_4540705_0	1536774.H70357_01380	1.824e-288	898.0	COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,4HBC7@91061|Bacilli,26SDU@186822|Paenibacillaceae	91061|Bacilli	G	Alpha-mannosidase	-	-	3.2.1.170,3.2.1.24	ko:K01191,ko:K15524	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
TLS2_k127_4549083_0	667014.Thein_1123	2.147e-107	358.0	COG0019@1|root,COG0019@2|Bacteria,2GHHY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS2_k127_4549083_4	1123388.AQWU01000043_gene386	7.319e-06	55.0	COG1470@1|root,COG3895@1|root,COG1470@2|Bacteria,COG3895@2|Bacteria,1WIA5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,PEGA
TLS2_k127_4549083_3	926562.Oweho_0154	1.068e-16	89.0	COG0671@1|root,COG0671@2|Bacteria,4NF6Z@976|Bacteroidetes,1HWVZ@117743|Flavobacteriia	976|Bacteroidetes	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS2_k127_4549083_1	1278073.MYSTI_01380	3.69e-45	177.0	COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,42QIS@68525|delta/epsilon subdivisions,2WMK0@28221|Deltaproteobacteria,2YV96@29|Myxococcales	28221|Deltaproteobacteria	K	WYL domain	-	-	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	HTH_11,WYL
TLS2_k127_4549083_2	1144275.COCOR_01249	1.846e-25	112.0	COG2378@1|root,COG2378@2|Bacteria,1QAGU@1224|Proteobacteria,434D3@68525|delta/epsilon subdivisions,2WYQ2@28221|Deltaproteobacteria,2Z0CG@29|Myxococcales	28221|Deltaproteobacteria	K	WYL domain	-	-	-	ko:K13572	-	-	-	-	ko00000,ko03051	-	-	-	WYL
TLS2_k127_4561993_3	234267.Acid_6884	8.339e-06	52.0	COG1310@1|root,COG1310@2|Bacteria	2|Bacteria	S	proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
TLS2_k127_4561993_4	1163407.UU7_12149	2.137e-05	56.0	COG1714@1|root,COG1714@2|Bacteria,1N1XF@1224|Proteobacteria,1SDY3@1236|Gammaproteobacteria,1X5Z4@135614|Xanthomonadales	135614|Xanthomonadales	NU	membrane protein domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,RDD
TLS2_k127_4561993_1	1408473.JHXO01000015_gene1893	1.689e-61	224.0	COG2013@1|root,COG2013@2|Bacteria	2|Bacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
TLS2_k127_4561993_2	1340493.JNIF01000003_gene3800	3.069e-07	60.0	COG2823@1|root,COG2823@2|Bacteria	2|Bacteria	S	hyperosmotic response	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS2_k127_4561993_0	1407650.BAUB01000015_gene2279	1.511e-85	291.0	COG1840@1|root,COG1840@2|Bacteria,1G33G@1117|Cyanobacteria	1117|Cyanobacteria	P	2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
TLS2_k127_4568951_8	1525715.IX54_10610	5.591e-06	57.0	COG0454@1|root,COG0456@2|Bacteria,1QUS0@1224|Proteobacteria,2TXDS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_4568951_2	1303518.CCALI_01925	3.884e-75	263.0	COG0179@1|root,COG0179@2|Bacteria	2|Bacteria	Q	Fumarylacetoacetate (FAA) hydrolase	-	-	5.3.3.10	ko:K01826	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R04379,R04482	RC01141,RC01162	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF2437,FAA_hydrolase
TLS2_k127_4568951_1	204669.Acid345_0549	8.001e-88	311.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,3Y38S@57723|Acidobacteria,2JHZB@204432|Acidobacteriia	204432|Acidobacteriia	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
TLS2_k127_4568951_0	204669.Acid345_2676	3.538e-125	419.0	COG0793@1|root,COG0793@2|Bacteria,3Y3KP@57723|Acidobacteria,2JHNE@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
TLS2_k127_4568951_7	1047013.AQSP01000099_gene1496	5.877e-16	80.0	COG1826@1|root,COG1826@2|Bacteria,2NQ3N@2323|unclassified Bacteria	2|Bacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116,ko:K03117,ko:K03646	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	2.A.64,2.C.1.2	-	-	MttA_Hcf106
TLS2_k127_4568951_3	204669.Acid345_2680	5.496e-66	239.0	COG0805@1|root,COG0805@2|Bacteria,3Y3UC@57723|Acidobacteria,2JISU@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
TLS2_k127_4568951_5	443143.GM18_3783	3.067e-30	133.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,42RVN@68525|delta/epsilon subdivisions,2WNJW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
TLS2_k127_4568951_6	1278073.MYSTI_00489	1.421e-25	118.0	COG0760@1|root,COG0760@2|Bacteria,1RKBZ@1224|Proteobacteria,42SAP@68525|delta/epsilon subdivisions,2WPWG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	peptidyl-prolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,SurA_N_3
TLS2_k127_4568951_4	234267.Acid_7421	3.25e-34	137.0	COG1197@1|root,COG1197@2|Bacteria,3Y3IE@57723|Acidobacteria	57723|Acidobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS2_k127_4578464_0	1340493.JNIF01000004_gene234	7.132e-187	609.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_4578464_1	1340493.JNIF01000003_gene3011	1.271e-25	114.0	COG1629@1|root,COG4771@2|Bacteria,3Y3KA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_457931_13	1120965.AUBV01000004_gene952	7.745e-14	74.0	COG3970@1|root,COG3970@2|Bacteria,4NGTH@976|Bacteroidetes,47MQU@768503|Cytophagia	976|Bacteroidetes	S	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	4.2.1.141	ko:K14259	ko00040,map00040	-	R09186	RC00429	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
TLS2_k127_457931_0	1382304.JNIL01000001_gene1413	4.398e-286	892.0	COG0129@1|root,COG0129@2|Bacteria,1U56J@1239|Firmicutes,4HD31@91061|Bacilli	91061|Bacilli	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82	ko:K22396	ko00040,map00040	-	R02429	RC00543	ko00000,ko00001,ko01000	-	-	-	ILVD_EDD
TLS2_k127_457931_2	521045.Kole_1769	3.952e-161	519.0	COG2610@1|root,COG2610@2|Bacteria,2GCMX@200918|Thermotogae	200918|Thermotogae	EG	PFAM Gluconate transporter	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
TLS2_k127_457931_6	1408473.JHXO01000014_gene4034	9.604e-107	353.0	COG0697@1|root,COG0697@2|Bacteria,4NHBC@976|Bacteroidetes,2FS9M@200643|Bacteroidia	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_457931_7	234267.Acid_5660	3.983e-83	293.0	COG0285@1|root,COG0285@2|Bacteria,3Y3ZA@57723|Acidobacteria	57723|Acidobacteria	H	Mur ligase, middle domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
TLS2_k127_457931_4	204669.Acid345_4701	7.066e-112	367.0	COG0777@1|root,COG0777@2|Bacteria,3Y2U9@57723|Acidobacteria,2JI81@204432|Acidobacteriia	204432|Acidobacteriia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_457931_14	945713.IALB_0804	5.803e-12	77.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP
TLS2_k127_457931_5	243231.GSU1767	2.059e-111	374.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,42MSB@68525|delta/epsilon subdivisions,2WJI6@28221|Deltaproteobacteria,43TW2@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TLS2_k127_457931_12	204669.Acid345_3427	1.003e-15	80.0	COG1722@1|root,COG1722@2|Bacteria,3Y5H0@57723|Acidobacteria,2JK24@204432|Acidobacteriia	204432|Acidobacteriia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
TLS2_k127_457931_9	1449126.JQKL01000010_gene459	3.282e-53	192.0	COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,248DE@186801|Clostridia,267X1@186813|unclassified Clostridiales	186801|Clostridia	H	Polyprenyl synthetase	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_457931_11	321332.CYB_1859	7.559e-34	134.0	COG0142@1|root,COG0142@2|Bacteria,1G1H4@1117|Cyanobacteria,1GZHB@1129|Synechococcus	1117|Cyanobacteria	H	Belongs to the FPP GGPP synthase family	crtE	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_457931_1	1121468.AUBR01000002_gene654	5.306e-222	706.0	COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,42EPX@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
TLS2_k127_457931_8	1125863.JAFN01000001_gene3505	7.438e-69	241.0	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,42R2J@68525|delta/epsilon subdivisions,2WIJ6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Ribosomal RNA methyltransferase RrmJ FtsJ	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
TLS2_k127_457931_3	289376.THEYE_A0114	1.23e-149	481.0	COG0473@1|root,COG0473@2|Bacteria,3J0JQ@40117|Nitrospirae	40117|Nitrospirae	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_457931_10	1121904.ARBP01000012_gene1301	3.996e-49	181.0	2DBK2@1|root,2Z9Q1@2|Bacteria,4NET4@976|Bacteroidetes,47MUQ@768503|Cytophagia	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4601033_0	1266914.ATUK01000006_gene33	1.208e-173	556.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
TLS2_k127_4601033_1	1173023.KE650771_gene1781	2.107e-168	541.0	COG2312@1|root,COG2312@2|Bacteria,1GA2Z@1117|Cyanobacteria	1117|Cyanobacteria	S	Erythromycin esterase	-	-	-	-	-	-	-	-	-	-	-	-	Erythro_esteras
TLS2_k127_4601033_4	765420.OSCT_0403	4.442e-118	392.0	COG0530@1|root,COG0530@2|Bacteria,2G6GV@200795|Chloroflexi,376V8@32061|Chloroflexia	32061|Chloroflexia	P	PFAM sodium calcium exchanger membrane region	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
TLS2_k127_4601033_3	1047013.AQSP01000125_gene2615	1.369e-147	481.0	COG2252@1|root,COG2252@2|Bacteria,2NNZ2@2323|unclassified Bacteria	2|Bacteria	S	Permease family	pbuG	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006863,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015205,GO:0015207,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015851,GO:0015853,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904823	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	iECH74115_1262.ECH74115_5145,iECOK1_1307.ECOK1_4117,iECSP_1301.ECSP_4762,iECUMN_1333.ECUMN_4191,iECs_1301.ECs4651,iG2583_1286.G2583_4505,iJO1366.b3714,iUTI89_1310.UTI89_C4220,iY75_1357.Y75_RS18500,iYO844.BSU06370,iZ_1308.Z5209	Xan_ur_permease
TLS2_k127_4601033_2	386456.JQKN01000001_gene2001	1.376e-149	483.0	COG1167@1|root,arCOG00492@2157|Archaea,2XVD6@28890|Euryarchaeota	28890|Euryarchaeota	E	PFAM Aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
TLS2_k127_460459_3	1191523.MROS_1419	5.267e-34	138.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_460459_0	234267.Acid_3614	1.605e-125	412.0	COG1060@1|root,COG1060@2|Bacteria,3Y2IA@57723|Acidobacteria	57723|Acidobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
TLS2_k127_460459_2	743721.Psesu_1933	8.597e-41	156.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,1S68H@1236|Gammaproteobacteria,1X6DF@135614|Xanthomonadales	135614|Xanthomonadales	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
TLS2_k127_460459_1	234267.Acid_2212	9.343e-118	387.0	COG2304@1|root,COG2304@2|Bacteria,3Y33Z@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase M64 N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	M64_N,Peptidase_M64
TLS2_k127_4606528_0	1144275.COCOR_05137	1.917e-321	1007.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2YUBZ@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA1	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
TLS2_k127_4606528_1	279714.FuraDRAFT_2812	3.704e-07	53.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,2VWDY@28216|Betaproteobacteria,2KRZB@206351|Neisseriales	206351|Neisseriales	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
TLS2_k127_4616037_2	1040986.ATYO01000011_gene5560	1.58e-38	156.0	COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,2TW5I@28211|Alphaproteobacteria,43R9W@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Periplasmic binding protein-like domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TLS2_k127_4616037_0	1174528.JH992893_gene5997	1.176e-82	286.0	COG2017@1|root,COG2017@2|Bacteria,1GGS7@1117|Cyanobacteria	1117|Cyanobacteria	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4616037_1	373903.Hore_04570	3.726e-68	244.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,3WAG1@53433|Halanaerobiales	186801|Clostridia	K	Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
TLS2_k127_4619664_0	234267.Acid_0392	1.387e-189	606.0	COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria	57723|Acidobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_4619664_1	945713.IALB_2157	7.507e-113	370.0	COG1297@1|root,COG1297@2|Bacteria	2|Bacteria	S	iron-nicotianamine transmembrane transporter activity	oliA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085	-	-	-	-	-	-	-	-	-	-	OPT
TLS2_k127_4630990_2	429009.Adeg_0541	6.042e-47	180.0	COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,42F4K@68295|Thermoanaerobacterales	186801|Clostridia	J	phenylalanyl-tRNA synthetase (beta subunit)	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
TLS2_k127_4630990_4	926566.Terro_0665	1.318e-14	77.0	COG3027@1|root,COG3027@2|Bacteria,3Y5IJ@57723|Acidobacteria,2JJZS@204432|Acidobacteriia	204432|Acidobacteriia	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
TLS2_k127_4630990_0	646529.Desaci_3210	1.557e-166	539.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,25ZZN@186807|Peptococcaceae	186801|Clostridia	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
TLS2_k127_4630990_1	1121430.JMLG01000001_gene2103	5.19e-92	313.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,24967@186801|Clostridia,2604A@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM metallophosphoesterase, MG_246 BB_0505 family	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
TLS2_k127_4630990_3	1379698.RBG1_1C00001G0659	3.137e-23	101.0	COG0178@1|root,COG0178@2|Bacteria,2NNT3@2323|unclassified Bacteria	2|Bacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_4639124_0	686340.Metal_2232	2.55e-119	427.0	COG0419@1|root,COG0419@2|Bacteria,1MVTQ@1224|Proteobacteria,1RQFM@1236|Gammaproteobacteria,1XGAI@135618|Methylococcales	135618|Methylococcales	L	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23,SbcCD_C
TLS2_k127_4639124_1	246197.MXAN_0958	1.575e-85	299.0	COG0420@1|root,COG0420@2|Bacteria,1MVV6@1224|Proteobacteria,42PFX@68525|delta/epsilon subdivisions,2WJS3@28221|Deltaproteobacteria,2YXB6@29|Myxococcales	28221|Deltaproteobacteria	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
TLS2_k127_4643070_1	1267535.KB906767_gene1893	0.0002844	47.0	2FF7H@1|root,3475G@2|Bacteria,3Y8K8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4643070_0	573413.Spirs_0986	1.963e-84	309.0	COG0840@1|root,COG1879@1|root,COG0840@2|Bacteria,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K03406,ko:K10439	ko02010,ko02020,ko02030,map02010,map02020,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000,ko02035	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	MCPsignal,Peripla_BP_4
TLS2_k127_4649396_1	682795.AciX8_3149	7.717e-08	57.0	COG1629@1|root,COG4771@2|Bacteria,3Y3Z6@57723|Acidobacteria,2JIQG@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_4649396_0	1123376.AUIU01000012_gene1512	0.0	1546.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,3J0TJ@40117|Nitrospirae	40117|Nitrospirae	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
TLS2_k127_4656814_1	861299.J421_5839	4.697e-20	104.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
TLS2_k127_4656814_0	1267535.KB906767_gene1645	3.248e-59	222.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_4657111_0	234267.Acid_6269	4.64e-169	557.0	COG0577@1|root,COG0577@2|Bacteria,3Y6MX@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_4667589_4	1267535.KB906767_gene3834	1.82e-20	98.0	COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_4667589_3	1499967.BAYZ01000195_gene3106	4.973e-133	442.0	COG1807@1|root,COG1807@2|Bacteria,2NPZC@2323|unclassified Bacteria	2|Bacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	MA20_19960	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_4667589_0	1382359.JIAL01000001_gene1409	3.189e-164	533.0	COG0457@1|root,COG0457@2|Bacteria,3Y3VT@57723|Acidobacteria,2JKYK@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS2_k127_4667589_1	204669.Acid345_0824	1.358e-157	518.0	COG0457@1|root,COG0457@2|Bacteria,3Y3VT@57723|Acidobacteria,2JKYK@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS2_k127_4667589_2	1382359.JIAL01000001_gene1409	2.282e-155	509.0	COG0457@1|root,COG0457@2|Bacteria,3Y3VT@57723|Acidobacteria,2JKYK@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS2_k127_4670144_10	1273538.G159_02760	4.705e-08	55.0	COG1984@1|root,COG1984@2|Bacteria,1TR6U@1239|Firmicutes,4HACC@91061|Bacilli,26D7N@186818|Planococcaceae	91061|Bacilli	E	Allophanate hydrolase subunit 2	kipA	-	-	ko:K06350	-	-	-	-	ko00000	-	-	-	CT_A_B
TLS2_k127_4670144_4	1173024.KI912148_gene4882	1.031e-160	519.0	COG2133@1|root,COG2133@2|Bacteria,1G2QD@1117|Cyanobacteria	1117|Cyanobacteria	G	PFAM Glucose Sorbosone dehydrogenase	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	GSDH
TLS2_k127_4670144_0	323848.Nmul_A2285	6.63e-304	944.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,371QW@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
TLS2_k127_4670144_7	1408428.JNJP01000125_gene2351	3.834e-51	192.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,42U06@68525|delta/epsilon subdivisions,2WP2C@28221|Deltaproteobacteria,2M7QN@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_4670144_3	518766.Rmar_2786	3.461e-189	601.0	COG2239@1|root,COG2239@2|Bacteria,4NGGN@976|Bacteroidetes,1FJBY@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	MgtE intracellular N domain	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
TLS2_k127_4670144_5	1121920.AUAU01000016_gene1288	3.884e-134	434.0	COG1013@1|root,COG1013@2|Bacteria,3Y514@57723|Acidobacteria	57723|Acidobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
TLS2_k127_4670144_2	1121920.AUAU01000016_gene1289	7.797e-248	778.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N,Transketolase_C
TLS2_k127_4670144_6	266117.Rxyl_1054	2.411e-61	222.0	COG0400@1|root,COG0400@2|Bacteria,2INMY@201174|Actinobacteria,4CTAJ@84995|Rubrobacteria	84995|Rubrobacteria	S	Dienelactone hydrolase family	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	DLH
TLS2_k127_4670144_1	1191523.MROS_0031	4.352e-291	904.0	COG4146@1|root,COG4146@2|Bacteria	2|Bacteria	S	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
TLS2_k127_468239_5	1123508.JH636445_gene6664	1.14e-11	72.0	COG0526@1|root,COG0526@2|Bacteria,2IZ08@203682|Planctomycetes	203682|Planctomycetes	CO	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_468239_6	1229780.BN381_180008	7.054e-11	75.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_468239_4	1163409.UUA_08551	3.52e-19	96.0	COG0500@1|root,COG2226@2|Bacteria,1R7IA@1224|Proteobacteria,1SIK7@1236|Gammaproteobacteria,1X5T5@135614|Xanthomonadales	135614|Xanthomonadales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_468239_3	1144275.COCOR_03035	2.343e-22	106.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
TLS2_k127_468239_1	448385.sce9148	2.237e-95	324.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,42PGW@68525|delta/epsilon subdivisions,2WMMZ@28221|Deltaproteobacteria,2YUHA@29|Myxococcales	28221|Deltaproteobacteria	C	NAD(P)H quinone oxidoreductase, PIG3 family	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_468239_0	518766.Rmar_2557	3.717e-143	468.0	COG2265@1|root,COG2265@2|Bacteria,4NFP1@976|Bacteroidetes,1FJUI@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	tRNA (Uracil-5-)-methyltransferase	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
TLS2_k127_468239_2	1123242.JH636435_gene1645	2.675e-40	156.0	COG2333@1|root,COG2333@2|Bacteria,2IZ4W@203682|Planctomycetes	203682|Planctomycetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_4684202_0	335543.Sfum_2437	7.382e-182	580.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2MRHY@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
TLS2_k127_4684202_2	525257.HMPREF0204_13611	4.035e-13	77.0	COG0845@1|root,COG0845@2|Bacteria,4NT55@976|Bacteroidetes,1IIHJ@117743|Flavobacteriia,3ZQBG@59732|Chryseobacterium	976|Bacteroidetes	M	Protein of unknown function (DUF3347)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3347
TLS2_k127_4699988_1	1408473.JHXO01000014_gene4069	2.722e-46	169.0	COG0657@1|root,COG2382@1|root,COG0657@2|Bacteria,COG2382@2|Bacteria,4NH62@976|Bacteroidetes,2FQH7@200643|Bacteroidia	976|Bacteroidetes	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
TLS2_k127_4699988_0	1232410.KI421428_gene1184	6.671e-148	490.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,43S4X@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
TLS2_k127_470821_0	1123242.JH636434_gene4741	1.92e-98	336.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_470821_1	1303518.CCALI_00287	6.641e-60	219.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS2_k127_470821_2	344747.PM8797T_22933	7.221e-34	146.0	COG1621@1|root,COG1621@2|Bacteria,2J36G@203682|Planctomycetes	203682|Planctomycetes	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4714795_3	1033743.CAES01000009_gene1927	1.028e-21	98.0	COG1649@1|root,COG1649@2|Bacteria,1UNKI@1239|Firmicutes,4IUH8@91061|Bacilli,277KZ@186822|Paenibacillaceae	91061|Bacilli	S	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6
TLS2_k127_4714795_1	1121904.ARBP01000019_gene2784	1.316e-106	357.0	COG3525@1|root,COG3525@2|Bacteria,4NGV2@976|Bacteroidetes,47TJT@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolase family 20, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_20
TLS2_k127_4714795_0	1267535.KB906767_gene1681	3.928e-134	441.0	COG0399@1|root,COG0399@2|Bacteria,3Y7K8@57723|Acidobacteria,2JK8Z@204432|Acidobacteriia	57723|Acidobacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_4714795_2	927658.AJUM01000037_gene2158	4.897e-36	138.0	COG0059@1|root,COG0059@2|Bacteria,4NFYV@976|Bacteroidetes,2FN0U@200643|Bacteroidia,3XJ20@558415|Marinilabiliaceae	976|Bacteroidetes	EH	Acetohydroxy acid isomeroreductase, catalytic domain	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
TLS2_k127_4715446_3	56107.Cylst_2368	2.453e-32	145.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG2461@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2461@2|Bacteria,1G09B@1117|Cyanobacteria,1HIE5@1161|Nostocales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_4715446_2	631362.Thi970DRAFT_02059	3.339e-72	268.0	COG2197@1|root,COG4585@1|root,COG2197@2|Bacteria,COG4585@2|Bacteria,1QTU2@1224|Proteobacteria	1224|Proteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,PAS_9,Response_reg
TLS2_k127_4715446_1	1123008.KB905692_gene286	3.58e-179	571.0	COG0477@1|root,COG2814@2|Bacteria,4NE09@976|Bacteroidetes,2FRW6@200643|Bacteroidia	976|Bacteroidetes	U	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	xylE	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
TLS2_k127_4715446_0	1250232.JQNJ01000001_gene3426	1.178e-221	701.0	arCOG07336@1|root,2Z8ST@2|Bacteria,4NIV5@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4716473_3	85643.Tmz1t_3286	9.935e-45	170.0	COG2834@1|root,COG2834@2|Bacteria,1RE9C@1224|Proteobacteria,2VPGB@28216|Betaproteobacteria,2KVYY@206389|Rhodocyclales	206389|Rhodocyclales	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
TLS2_k127_4716473_6	290317.Cpha266_1096	2.669e-26	122.0	28IZT@1|root,2Z8X3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4716473_1	278963.ATWD01000002_gene215	7.315e-54	212.0	COG3275@1|root,COG3275@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	lytS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K02478,ko:K07704	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	iECW_1372.ECW_m2327,iWFL_1372.ECW_m2327	5TM-5TMR_LYT,ECF_trnsprt,GAF_3,HATPase_c,His_kinase
TLS2_k127_4716473_5	1122134.KB893650_gene239	8.468e-29	129.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,1XJVK@135619|Oceanospirillales	135619|Oceanospirillales	K	Response regulator of the LytR AlgR family	algR	-	-	ko:K02477,ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
TLS2_k127_4716473_0	234267.Acid_6601	6.438e-55	206.0	COG0265@1|root,COG2203@1|root,COG2208@1|root,COG0265@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4A2@57723|Acidobacteria	57723|Acidobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_3,RibD_C,SpoIIE
TLS2_k127_4716473_2	1267534.KB906759_gene1765	8.109e-46	176.0	COG3279@1|root,COG3279@2|Bacteria,3Y7UE@57723|Acidobacteria,2JP1S@204432|Acidobacteriia	204432|Acidobacteriia	KT	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
TLS2_k127_4716473_7	1038860.AXAP01000083_gene431	0.0008148	52.0	COG0457@1|root,COG0457@2|Bacteria,1R8QI@1224|Proteobacteria,2U3CP@28211|Alphaproteobacteria,3JUFE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
TLS2_k127_4716473_4	1454004.AW11_01914	8.207e-31	126.0	COG1765@1|root,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2VU1M@28216|Betaproteobacteria,1KQXZ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	OsmC-like protein	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
TLS2_k127_4719911_0	1121904.ARBP01000013_gene349	1.67e-165	530.0	COG4948@1|root,COG4948@2|Bacteria,4NKNN@976|Bacteroidetes,47JKW@768503|Cytophagia	976|Bacteroidetes	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_4719911_5	234267.Acid_5068	6.713e-12	75.0	2FHPT@1|root,349HD@2|Bacteria,3Y8EI@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4719911_3	344747.PM8797T_30856	1.729e-119	395.0	COG0412@1|root,COG0412@2|Bacteria,2IYJ7@203682|Planctomycetes	203682|Planctomycetes	Q	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4719911_1	1121011.AUCB01000002_gene485	6.192e-129	421.0	COG3828@1|root,COG3828@2|Bacteria,4NJK6@976|Bacteroidetes,1I11T@117743|Flavobacteriia,23GTH@178469|Arenibacter	976|Bacteroidetes	S	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
TLS2_k127_4719911_4	521674.Plim_3510	3.397e-77	276.0	COG0673@1|root,COG0673@2|Bacteria,2IXRR@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4732526_1	56780.SYN_01757	3.416e-07	60.0	COG4966@1|root,COG4966@2|Bacteria,1Q8WE@1224|Proteobacteria,439J3@68525|delta/epsilon subdivisions,2X4VK@28221|Deltaproteobacteria,2MSHQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
TLS2_k127_4732526_2	945550.VISI1226_02165	0.000488	48.0	COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,1SCES@1236|Gammaproteobacteria,1XYET@135623|Vibrionales	135623|Vibrionales	NU	Belongs to the N-Me-Phe pilin family	pilA	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin
TLS2_k127_4732526_0	316067.Geob_2945	2.802e-45	172.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,42TZY@68525|delta/epsilon subdivisions,2WRWF@28221|Deltaproteobacteria,43UKD@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, crp family	fnr-2	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_4735486_0	1123023.JIAI01000004_gene7857	2.55e-54	212.0	2EXXE@1|root,33R6H@2|Bacteria,2H1T6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4735486_1	1123023.JIAI01000004_gene7958	0.0005626	51.0	2EXXE@1|root,33R6H@2|Bacteria,2H1T6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4737560_0	204669.Acid345_4231	8.164e-90	307.0	COG5009@1|root,COG5009@2|Bacteria,3Y31C@57723|Acidobacteria,2JHJY@204432|Acidobacteriia	204432|Acidobacteriia	M	Penicillin-binding protein 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS2_k127_4737560_1	1382359.JIAL01000001_gene116	3.117e-25	109.0	COG0142@1|root,COG0142@2|Bacteria,3Y2VJ@57723|Acidobacteria,2JHS0@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_4763933_2	452637.Oter_2179	1.335e-78	265.0	COG2303@1|root,COG2303@2|Bacteria,46V33@74201|Verrucomicrobia	74201|Verrucomicrobia	E	GMC oxidoreductase	betA	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_4763933_1	452637.Oter_2180	1.402e-98	336.0	2EZW8@1|root,33T0M@2|Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
TLS2_k127_4763933_3	880073.Calab_3690	2.462e-12	69.0	COG3360@1|root,COG3360@2|Bacteria	2|Bacteria	P	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
TLS2_k127_4763933_0	1191523.MROS_0619	6.962e-237	748.0	COG1022@1|root,COG1022@2|Bacteria	2|Bacteria	I	Amp-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS2_k127_4763933_4	123214.PERMA_0293	7.374e-08	62.0	COG1074@1|root,COG1074@2|Bacteria,2G4KP@200783|Aquificae	200783|Aquificae	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS2_k127_4766673_4	1215092.PA6_002_00780	2.68e-18	90.0	COG5563@1|root,COG5563@2|Bacteria,1R9G5@1224|Proteobacteria	1224|Proteobacteria	M	HAF family	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
TLS2_k127_4766673_1	755178.Cyan10605_3514	3.885e-41	154.0	COG4679@1|root,COG4679@2|Bacteria,1G6SB@1117|Cyanobacteria	1117|Cyanobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
TLS2_k127_4766673_2	671143.DAMO_0428	9.418e-36	140.0	COG1476@1|root,COG1476@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31
TLS2_k127_4766673_3	543728.Vapar_2294	1.721e-32	129.0	2DMB2@1|root,32UGJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Calci_bind_CcbP
TLS2_k127_4770289_0	1047013.AQSP01000120_gene936	0.0	1158.0	COG4354@1|root,COG4354@2|Bacteria,2NQ9B@2323|unclassified Bacteria	2|Bacteria	G	beta-glucosidase 2, glycosyl-hydrolase family 116 N-term	-	-	-	-	-	-	-	-	-	-	-	-	DUF608,Glyco_hydr_116N
TLS2_k127_4770289_1	1499967.BAYZ01000123_gene2555	1.886e-82	279.0	COG2195@1|root,COG2195@2|Bacteria,2NPYT@2323|unclassified Bacteria	2|Bacteria	E	Cleaves the N-terminal amino acid of tripeptides	pepT	GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0034701,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045148,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M42
TLS2_k127_4778829_1	761193.Runsl_5566	1.586e-75	261.0	COG1619@1|root,COG1619@2|Bacteria,4NF5Q@976|Bacteroidetes,47KS4@768503|Cytophagia	976|Bacteroidetes	V	peptidase U61 LD-carboxypeptidase A	ldcA	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
TLS2_k127_4778829_0	1121920.AUAU01000018_gene1826	4.83e-140	459.0	COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria	57723|Acidobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
TLS2_k127_4778829_2	1218075.BAYA01000012_gene3564	5.263e-07	59.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,1K0VI@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Peptidase M48	yggG_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
TLS2_k127_4802453_6	525904.Tter_0501	0.0001546	46.0	COG1475@1|root,COG1475@2|Bacteria,2NP7S@2323|unclassified Bacteria	2|Bacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
TLS2_k127_4802453_0	639030.JHVA01000001_gene2324	5.522e-105	356.0	COG0486@1|root,COG0486@2|Bacteria,3Y3QJ@57723|Acidobacteria,2JHNN@204432|Acidobacteriia	204432|Acidobacteriia	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
TLS2_k127_4802453_3	867845.KI911784_gene2746	3.06e-23	104.0	COG1847@1|root,COG1847@2|Bacteria,2G6XH@200795|Chloroflexi,375F5@32061|Chloroflexia	32061|Chloroflexia	S	PFAM single-stranded nucleic acid binding R3H domain protein	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
TLS2_k127_4802453_1	204669.Acid345_0217	1.405e-69	257.0	COG0706@1|root,COG0706@2|Bacteria,3Y3TD@57723|Acidobacteria,2JI2B@204432|Acidobacteriia	204432|Acidobacteriia	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
TLS2_k127_4802453_2	321327.CYA_2594	2.83e-29	118.0	COG0759@1|root,COG0759@2|Bacteria,1G90B@1117|Cyanobacteria,1H14U@1129|Synechococcus	1117|Cyanobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
TLS2_k127_4802453_4	637390.AFOH01000102_gene205	1.624e-15	80.0	COG0594@1|root,COG0594@2|Bacteria,1NGQJ@1224|Proteobacteria,1T8KZ@1236|Gammaproteobacteria,2ND3B@225057|Acidithiobacillales	225057|Acidithiobacillales	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
TLS2_k127_4802453_5	1178540.BA70_08645	4.408e-07	51.0	COG0230@1|root,COG0230@2|Bacteria,1VK90@1239|Firmicutes,4HR2Z@91061|Bacilli,1ZJ74@1386|Bacillus	91061|Bacilli	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
TLS2_k127_4812631_0	639030.JHVA01000001_gene2855	7.813e-58	207.0	COG3191@1|root,COG3191@2|Bacteria	2|Bacteria	EQ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
TLS2_k127_4812631_3	240015.ACP_1604	3.651e-15	87.0	2DBU8@1|root,2ZB4S@2|Bacteria,3Y31B@57723|Acidobacteria,2JIT7@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
TLS2_k127_4812631_2	240015.ACP_1605	1.519e-28	122.0	COG2020@1|root,COG2020@2|Bacteria,3Y4P4@57723|Acidobacteria,2JJBQ@204432|Acidobacteriia	204432|Acidobacteriia	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TLS2_k127_4812631_1	574087.Acear_2169	1.43e-40	160.0	COG0859@1|root,COG0859@2|Bacteria,1TRN2@1239|Firmicutes,24W0F@186801|Clostridia,3WB26@53433|Halanaerobiales	186801|Clostridia	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02841,ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TLS2_k127_481833_1	1337936.IJ00_13055	8.266e-19	88.0	COG4634@1|root,COG4634@2|Bacteria,1G79I@1117|Cyanobacteria,1HPPU@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mut7-C
TLS2_k127_481833_0	706587.Desti_5304	1.867e-126	411.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_4820460_3	552811.Dehly_0239	7.627e-30	123.0	COG1331@1|root,COG1331@2|Bacteria,2G5R1@200795|Chloroflexi	200795|Chloroflexi	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
TLS2_k127_4820460_2	420246.GTNG_2593	1.143e-47	177.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,4HCP6@91061|Bacilli,1WF41@129337|Geobacillus	91061|Bacilli	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
TLS2_k127_4820460_0	643648.Slip_2050	2.652e-86	295.0	COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,42JMQ@68298|Syntrophomonadaceae	186801|Clostridia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	Ham1p_like,RNase_PH,RNase_PH_C
TLS2_k127_4820460_5	243231.GSU2922	1.527e-07	60.0	COG5401@1|root,COG5401@2|Bacteria,1NA0G@1224|Proteobacteria,42V1V@68525|delta/epsilon subdivisions,2WRCV@28221|Deltaproteobacteria,43V6T@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
TLS2_k127_4820460_4	82654.Pse7367_2099	2.21e-18	99.0	COG0860@1|root,COG0860@2|Bacteria,1G008@1117|Cyanobacteria,1H876@1150|Oscillatoriales	1117|Cyanobacteria	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
TLS2_k127_4820460_1	234267.Acid_1153	1.941e-83	286.0	COG0774@1|root,COG0774@2|Bacteria,3Y40I@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
TLS2_k127_4823728_2	1122931.AUAE01000007_gene1342	1.976e-76	275.0	COG0457@1|root,COG0457@2|Bacteria,4NKMF@976|Bacteroidetes,2FXC5@200643|Bacteroidia,231HD@171551|Porphyromonadaceae	1122931.AUAE01000007_gene1342|-	S	Domain of unknown function (DUF5107)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4823728_1	316067.Geob_1699	9.502e-102	336.0	COG1143@1|root,COG3260@1|root,COG1143@2|Bacteria,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42NH3@68525|delta/epsilon subdivisions,2WJX8@28221|Deltaproteobacteria,43T9P@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7,Oxidored_q6
TLS2_k127_4823728_0	338966.Ppro_0340	5.837e-103	340.0	COG3261@1|root,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,42NJH@68525|delta/epsilon subdivisions,2WJ6J@28221|Deltaproteobacteria,43SVB@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	ehrL	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa
TLS2_k127_4834458_0	309807.SRU_0977	4.588e-90	317.0	2AB2F@1|root,310G6@2|Bacteria,4PEZP@976|Bacteroidetes,1FJWS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4834458_2	1340493.JNIF01000003_gene1818	7.904e-14	79.0	COG0457@1|root,COG0457@2|Bacteria	1340493.JNIF01000003_gene1818|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4834458_1	1382359.JIAL01000001_gene2312	1.699e-26	127.0	COG2911@1|root,COG2911@2|Bacteria,3Y3A6@57723|Acidobacteria,2JHS8@204432|Acidobacteriia	204432|Acidobacteriia	M	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
TLS2_k127_4847423_3	234267.Acid_5737	1.838e-30	128.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4847423_4	646529.Desaci_1130	1.712e-15	89.0	COG5662@1|root,COG5662@2|Bacteria,1U13D@1239|Firmicutes,24AF3@186801|Clostridia,262HU@186807|Peptococcaceae	186801|Clostridia	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	DUF2275,DUF4367,zf-HC2
TLS2_k127_4847423_1	526227.Mesil_0789	7.424e-101	338.0	COG1131@1|root,COG1131@2|Bacteria,1WJ0H@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4847423_2	383372.Rcas_3764	2.631e-66	235.0	COG1277@1|root,COG1277@2|Bacteria,2G79P@200795|Chloroflexi	200795|Chloroflexi	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
TLS2_k127_4847423_0	5786.XP_003285755.1	1.05e-236	764.0	COG0334@1|root,KOG2250@2759|Eukaryota,3X8HF@554915|Amoebozoa	554915|Amoebozoa	E	Glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH,ELFV_dehydrog
TLS2_k127_4868709_4	1499967.BAYZ01000095_gene4055	5.13e-34	132.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.82	ko:K18815	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
TLS2_k127_4868709_5	234267.Acid_3490	2.76e-29	136.0	2DBAV@1|root,2Z84I@2|Bacteria,3Y9AH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4868709_8	402880.MmarC5_0406	1.727e-05	54.0	COG0456@1|root,arCOG00833@2157|Archaea,2XYEG@28890|Euryarchaeota,23R5N@183939|Methanococci	183939|Methanococci	K	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TLS2_k127_4868709_7	378806.STAUR_5061	1.595e-13	83.0	2A7N3@1|root,30WK3@2|Bacteria,1NERD@1224|Proteobacteria,42P7M@68525|delta/epsilon subdivisions,2WJTH@28221|Deltaproteobacteria,2YWBS@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4868709_2	1121405.dsmv_2218	3.144e-167	543.0	COG1960@1|root,COG1960@2|Bacteria,1NU73@1224|Proteobacteria,42Z96@68525|delta/epsilon subdivisions,2WTTK@28221|Deltaproteobacteria,2MN2J@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_4868709_3	1487953.JMKF01000022_gene2498	3.85e-80	271.0	COG2818@1|root,COG2818@2|Bacteria,1G5Y1@1117|Cyanobacteria	1117|Cyanobacteria	L	Methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
TLS2_k127_4868709_0	335543.Sfum_0389	2.169e-223	702.0	COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,42MB6@68525|delta/epsilon subdivisions,2WJMI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Acetyl-CoA hydrolase transferase	ato-2	-	3.1.2.1	ko:K01067	ko00620,map00620	-	R00227	RC00004,RC00012	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1125	AcetylCoA_hyd_C,AcetylCoA_hydro
TLS2_k127_4868709_1	575540.Isop_1585	7.68e-193	612.0	COG1883@1|root,COG1883@2|Bacteria,2IYPW@203682|Planctomycetes	203682|Planctomycetes	C	Na+-transporting oxaloacetate decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
TLS2_k127_4868709_6	1521187.JPIM01000031_gene1999	1.212e-23	104.0	COG0511@1|root,COG0511@2|Bacteria	2|Bacteria	I	ligase activity, forming carbon-carbon bonds	oadA	-	2.3.1.12,6.4.1.1,6.4.1.7	ko:K00627,ko:K01960,ko:K20140	ko00010,ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map01230	M00173,M00307,M00620	R00209,R00344,R02569	RC00004,RC00040,RC00367,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_5346	Biotin_lipoyl,HMGL-like,PYC_OADA
TLS2_k127_4870880_2	266117.Rxyl_2544	1.028e-111	365.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,2GKN1@201174|Actinobacteria,4CRR1@84995|Rubrobacteria	84995|Rubrobacteria	C	CoA-binding	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
TLS2_k127_4870880_0	329726.AM1_5447	2.764e-169	549.0	COG0464@1|root,COG0464@2|Bacteria,1G2M7@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
TLS2_k127_4870880_8	204669.Acid345_0034	2.505e-23	102.0	COG2331@1|root,COG2331@2|Bacteria,3Y5KN@57723|Acidobacteria,2JJW0@204432|Acidobacteriia	204432|Acidobacteriia	S	Regulatory protein, FmdB	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TLS2_k127_4870880_1	589865.DaAHT2_1347	9.377e-140	456.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2WJ7H@28221|Deltaproteobacteria,2MIPF@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC,GARS_A,GARS_C,GARS_N
TLS2_k127_4870880_5	1380391.JIAS01000015_gene104	2.092e-49	181.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2U58D@28211|Alphaproteobacteria,2JRTF@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
TLS2_k127_4870880_6	293826.Amet_2867	4.306e-35	143.0	COG1496@1|root,COG1496@2|Bacteria,1TS34@1239|Firmicutes,248TD@186801|Clostridia,36I6A@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
TLS2_k127_4870880_7	247490.KSU1_C1583	2.951e-32	129.0	COG0736@1|root,COG0736@2|Bacteria,2IZSD@203682|Planctomycetes	203682|Planctomycetes	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_4870880_3	204669.Acid345_1211	4.644e-101	344.0	COG0621@1|root,COG0621@2|Bacteria,3Y41R@57723|Acidobacteria,2JKPA@204432|Acidobacteriia	204432|Acidobacteriia	J	Uncharacterized protein family UPF0004	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
TLS2_k127_4870880_4	105559.Nwat_0767	7.029e-94	319.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1WWD4@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
TLS2_k127_4870880_9	1240350.AMZE01000050_gene892	7.633e-15	81.0	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,1S2TG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I	yycJ	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_4872563_0	1198114.AciX9_2321	3.035e-133	444.0	COG2010@1|root,COG2010@2|Bacteria,3Y6T1@57723|Acidobacteria,2JM3M@204432|Acidobacteriia	204432|Acidobacteriia	C	Protein of unknown function (DUF1553)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
TLS2_k127_4872563_1	234267.Acid_4060	1.104e-114	377.0	COG4102@1|root,COG4102@2|Bacteria,3Y6RN@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_4872747_3	525897.Dbac_0380	3.317e-26	109.0	COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42P55@68525|delta/epsilon subdivisions,2WKYQ@28221|Deltaproteobacteria,2MARP@213115|Desulfovibrionales	28221|Deltaproteobacteria	EH	TIGRFAM para-aminobenzoate synthase, subunit I	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4,Chorismate_bind
TLS2_k127_4872747_1	452637.Oter_3045	8.484e-277	868.0	COG0457@1|root,COG0457@2|Bacteria	452637.Oter_3045|-	S	peptidyl-tyrosine sulfation	-	-	3.4.14.4	ko:K01277	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	-
TLS2_k127_4872747_0	694427.Palpr_0579	0.0	1159.0	COG3250@1|root,COG3250@2|Bacteria,4NKZX@976|Bacteroidetes,2FNTC@200643|Bacteroidia,22ZRF@171551|Porphyromonadaceae	976|Bacteroidetes	G	Concanavalin A-like lectin/glucanases superfamily	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Laminin_G_3
TLS2_k127_4872747_2	1392498.JQLH01000001_gene3349	1.329e-74	257.0	COG0388@1|root,COG0388@2|Bacteria,4PE65@976|Bacteroidetes,1IENF@117743|Flavobacteriia,2PIBH@252356|Maribacter	976|Bacteroidetes	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS2_k127_4872779_2	765914.ThisiDRAFT_2684	8.161e-38	148.0	COG1959@1|root,COG1959@2|Bacteria	2|Bacteria	K	2 iron, 2 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TLS2_k127_4872779_1	1125863.JAFN01000001_gene2796	4.64e-174	566.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42PJ7@68525|delta/epsilon subdivisions,2WMEM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
TLS2_k127_4872779_3	1125863.JAFN01000001_gene2795	3.659e-34	138.0	COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42VKD@68525|delta/epsilon subdivisions,2WRHY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Rieske 2Fe-2S domain	pcmE	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
TLS2_k127_4872779_0	1125863.JAFN01000001_gene2794	1.691e-212	671.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WMNX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Cytochrome b b6 domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
TLS2_k127_4872779_4	671143.DAMO_0769	1.862e-26	122.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	pcmF	-	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C,Cytochrome_CBB3
TLS2_k127_4875645_4	1267535.KB906767_gene1489	7.539e-80	293.0	COG1452@1|root,COG1452@2|Bacteria,3Y37B@57723|Acidobacteria,2JHPP@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Organic solvent tolerance protein	-	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA_C
TLS2_k127_4875645_6	1382356.JQMP01000003_gene1502	7.217e-37	149.0	COG0801@1|root,COG0801@2|Bacteria,2G6YT@200795|Chloroflexi,27YCY@189775|Thermomicrobia	189775|Thermomicrobia	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	-	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
TLS2_k127_4875645_0	1185876.BN8_02272	2.087e-255	801.0	COG4225@1|root,COG4225@2|Bacteria,4NF1N@976|Bacteroidetes,47K76@768503|Cytophagia	976|Bacteroidetes	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4962,Hepar_II_III
TLS2_k127_4875645_2	240016.ABIZ01000001_gene1588	1.173e-106	362.0	COG0673@1|root,COG0673@2|Bacteria,46TM9@74201|Verrucomicrobia,2ITZ3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_4875645_5	1047013.AQSP01000028_gene2077	2.476e-55	203.0	COG0681@1|root,COG0681@2|Bacteria,2NPIA@2323|unclassified Bacteria	2|Bacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS2_k127_4875645_1	880073.Calab_1318	1.903e-149	485.0	COG0508@1|root,COG0508@2|Bacteria,2NP69@2323|unclassified Bacteria	2|Bacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	aceF	GO:0003674,GO:0003824,GO:0004742,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016407,GO:0016417,GO:0016418,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030523,GO:0031405,GO:0031406,GO:0032787,GO:0032991,GO:0033293,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1902494,GO:1990204	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iETEC_1333.ETEC_0111,iSSON_1240.SSON_0123,iYL1228.KPN_00119	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_4875645_3	1191523.MROS_0859	4.112e-104	343.0	COG2609@1|root,COG2609@2|Bacteria	2|Bacteria	C	pyruvate dehydrogenase (acetyl-transferring) activity	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS2_k127_4887686_1	234267.Acid_7590	5.37e-173	570.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_7590|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4887686_4	485917.Phep_3108	1.427e-13	82.0	COG4225@1|root,COG4225@2|Bacteria,4NH7G@976|Bacteroidetes,1IRFG@117747|Sphingobacteriia	976|Bacteroidetes	S	Glycosyl Hydrolase Family 88	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
TLS2_k127_4887686_2	1340493.JNIF01000003_gene4018	2.098e-74	268.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_7,DLH
TLS2_k127_4887686_0	234267.Acid_1183	1.017e-203	653.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,3Y6RM@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Pyrrolo-quinoline quinone	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
TLS2_k127_4887686_3	1340493.JNIF01000003_gene3494	4.988e-45	180.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	3.1.1.102	ko:K06978,ko:K21105	-	-	R11541	RC00020,RC00041	ko00000,ko01000	-	-	-	AXE1,Big_5,LTD,Peptidase_S9,Tannase
TLS2_k127_4888635_0	335543.Sfum_3516	1.679e-197	620.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2MQTV@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C
TLS2_k127_4888635_1	267608.RSc1476	3.519e-66	231.0	COG0744@1|root,COG0768@1|root,COG0744@2|Bacteria,COG0768@2|Bacteria,1NRPB@1224|Proteobacteria,2VJ7F@28216|Betaproteobacteria,1JZUT@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
TLS2_k127_4893809_2	204669.Acid345_0391	1.459e-91	304.0	COG0172@1|root,COG0172@2|Bacteria,3Y2UD@57723|Acidobacteria,2JI0N@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TLS2_k127_4893809_5	756499.Desde_1508	2.493e-08	65.0	COG1725@1|root,COG1725@2|Bacteria,1V743@1239|Firmicutes,24J7Q@186801|Clostridia,2633U@186807|Peptococcaceae	186801|Clostridia	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
TLS2_k127_4893809_3	1128421.JAGA01000002_gene26	3.536e-64	232.0	COG1816@1|root,COG1816@2|Bacteria,2NR0J@2323|unclassified Bacteria	2|Bacteria	F	Adenosine/AMP deaminase	add	GO:0000034,GO:0003674,GO:0003824,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.4.2,3.5.4.4,3.5.4.40	ko:K01488,ko:K18286,ko:K21053	ko00130,ko00230,ko01100,ko01110,ko05340,map00130,map00230,map01100,map01110,map05340	-	R01244,R01560,R02556,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
TLS2_k127_4893809_0	595460.RRSWK_03299	2.902e-166	539.0	COG1282@1|root,COG1282@2|Bacteria,2IYIA@203682|Planctomycetes	203682|Planctomycetes	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
TLS2_k127_4893809_4	1123279.ATUS01000003_gene402	6.093e-30	126.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,1S9UK@1236|Gammaproteobacteria,1J6H9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG3288 NAD NADP transhydrogenase alpha subunit	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
TLS2_k127_4893809_1	1121403.AUCV01000007_gene1231	3.114e-131	428.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,42NHC@68525|delta/epsilon subdivisions,2WJQJ@28221|Deltaproteobacteria,2MJKV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Alanine dehydrogenase/PNT, C-terminal domain	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
TLS2_k127_4893809_6	1121405.dsmv_1387	0.0001025	49.0	COG0477@1|root,COG0477@2|Bacteria,1MWUR@1224|Proteobacteria,43BPW@68525|delta/epsilon subdivisions,2X714@28221|Deltaproteobacteria,2MPJ0@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4904061_2	1304880.JAGB01000002_gene1891	2.458e-30	123.0	COG2730@1|root,COG2730@2|Bacteria,1TQS6@1239|Firmicutes,24A54@186801|Clostridia	186801|Clostridia	G	Protein of unknown function (DUF4038)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038
TLS2_k127_4904061_1	666684.AfiDRAFT_3090	1.858e-57	224.0	COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2TSY5@28211|Alphaproteobacteria,3JWP1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA_3,PAS_4,PAS_9,PHY,Response_reg
TLS2_k127_4904061_0	1183438.GKIL_4354	1.807e-97	339.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_4906460_1	1121957.ATVL01000008_gene4646	2.485e-30	136.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,4NK8Q@976|Bacteroidetes,47KVN@768503|Cytophagia	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
TLS2_k127_4906460_0	1185876.BN8_02874	7.442e-39	155.0	28IQI@1|root,2Z8Q7@2|Bacteria,4NKRK@976|Bacteroidetes,47W0I@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4906460_2	1459636.NTE_02393	0.0005655	50.0	arCOG03439@1|root,arCOG03439@2157|Archaea	2157|Archaea	L	PFAM periplasmic copper-binding	-	-	3.4.23.42	ko:K01385	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CARDB,CUB,Peptidase_C25,Polysacc_deac_1,Propeptide_C25
TLS2_k127_4906486_3	324602.Caur_3100	1.774e-52	191.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_4906486_2	1267535.KB906767_gene780	4.235e-61	216.0	COG0231@1|root,COG0231@2|Bacteria,3Y373@57723|Acidobacteria,2JIEA@204432|Acidobacteriia	204432|Acidobacteriia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	-	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TLS2_k127_4906486_0	204669.Acid345_3065	1.702e-186	597.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,3Y5CQ@57723|Acidobacteria,2JKVX@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO
TLS2_k127_4906486_1	324602.Caur_3136	2.354e-122	409.0	COG0477@1|root,COG0477@2|Bacteria,2G5J9@200795|Chloroflexi,377YG@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4907057_3	1267535.KB906767_gene1842	1.846e-23	104.0	COG1033@1|root,COG1033@2|Bacteria	2|Bacteria	S	growth of symbiont in host cell	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_4907057_1	1123368.AUIS01000004_gene113	1.857e-75	264.0	COG1108@1|root,COG1108@2|Bacteria,1RGT1@1224|Proteobacteria,1RZRB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	pfam abc-3	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
TLS2_k127_4907057_2	1123368.AUIS01000004_gene112	2.488e-55	199.0	COG0488@1|root,COG0488@2|Bacteria,1RJA9@1224|Proteobacteria,1T0HU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_4907057_0	1123368.AUIS01000004_gene111	1.068e-114	376.0	COG0803@1|root,COG0803@2|Bacteria,1PQEX@1224|Proteobacteria,1RYA2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	periplasmic solute binding protein	znuA	-	-	ko:K02077	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
TLS2_k127_4908224_1	1232410.KI421421_gene3311	2.27e-25	106.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2WN60@28221|Deltaproteobacteria,43UE3@69541|Desulfuromonadales	28221|Deltaproteobacteria	FP	metal-dependent phosphohydrolase, HD sub domain	gppA-2	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
TLS2_k127_4908224_0	349521.HCH_04427	1.33e-119	391.0	2DP71@1|root,330U0@2|Bacteria,1R5A0@1224|Proteobacteria,1RS7S@1236|Gammaproteobacteria,1XM3N@135619|Oceanospirillales	135619|Oceanospirillales	S	Protein of unknown function (DUF2971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2971
TLS2_k127_4908224_3	1265505.ATUG01000001_gene4409	4.446e-11	75.0	COG0607@1|root,COG0607@2|Bacteria,1P5S7@1224|Proteobacteria,432U2@68525|delta/epsilon subdivisions,2WXWU@28221|Deltaproteobacteria,2MPCG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4909052_0	204669.Acid345_0175	7.604e-244	770.0	COG0317@1|root,COG0317@2|Bacteria,3Y38Q@57723|Acidobacteria,2JIN0@204432|Acidobacteriia	204432|Acidobacteriia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TLS2_k127_4909052_9	401053.AciPR4_0433	4.959e-27	111.0	COG0227@1|root,COG0227@2|Bacteria,3Y5KC@57723|Acidobacteria,2JJYY@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
TLS2_k127_4909052_2	1452718.JBOY01000142_gene1502	1.015e-132	435.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed	atoB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_4909052_4	1120973.AQXL01000132_gene2248	7.324e-103	342.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,4HA59@91061|Bacilli,279C1@186823|Alicyclobacillaceae	91061|Bacilli	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	mmgB	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_4909052_1	880073.Calab_1189	1.112e-152	490.0	COG0468@1|root,COG0468@2|Bacteria,2NNYW@2323|unclassified Bacteria	2|Bacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046483,GO:0050896,GO:0051704,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TLS2_k127_4909052_7	485916.Dtox_2416	1.741e-62	226.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,260YT@186807|Peptococcaceae	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_4909052_6	234267.Acid_7871	5.947e-83	297.0	COG0616@1|root,COG0616@2|Bacteria,3Y3M1@57723|Acidobacteria	57723|Acidobacteria	OU	PFAM peptidase S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TLS2_k127_4909052_5	1341151.ASZU01000020_gene1048	5.734e-98	329.0	COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,4H9MA@91061|Bacilli,27AY1@186824|Thermoactinomycetaceae	91061|Bacilli	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	glxR	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_4909052_8	1128421.JAGA01000001_gene2006	1.153e-41	157.0	COG2363@1|root,COG2363@2|Bacteria,2NRMS@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF423)	ywdK	-	-	-	-	-	-	-	-	-	-	-	DUF423
TLS2_k127_4909052_10	1536774.H70357_30710	2.243e-06	56.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,4HDSE@91061|Bacilli,26V76@186822|Paenibacillaceae	91061|Bacilli	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_4909052_3	926569.ANT_14230	1.77e-113	369.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2G5W2@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS2_k127_4910595_3	1405.DJ92_1418	6.775e-45	166.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,4H9KA@91061|Bacilli,1ZC0R@1386|Bacillus	91061|Bacilli	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_4910595_4	224324.aq_702	1.487e-38	148.0	COG0789@1|root,COG0789@2|Bacteria,2G4AP@200783|Aquificae	200783|Aquificae	K	helix_turn_helix, mercury resistance	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
TLS2_k127_4910595_5	1382359.JIAL01000001_gene1778	2.593e-16	87.0	COG1238@1|root,COG1238@2|Bacteria,3Y52F@57723|Acidobacteria,2JJK2@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_4910595_6	1382359.JIAL01000001_gene883	7.389e-13	80.0	COG2834@1|root,COG2834@2|Bacteria,3Y4A1@57723|Acidobacteria,2JJ5F@204432|Acidobacteriia	204432|Acidobacteriia	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4292
TLS2_k127_4910595_1	204669.Acid345_0559	6.426e-72	256.0	COG4591@1|root,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,LolA_like,MacB_PCD
TLS2_k127_4910595_0	240015.ACP_2560	2.921e-74	257.0	COG1136@1|root,COG1136@2|Bacteria,3Y3JD@57723|Acidobacteria,2JIHH@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4910595_7	35841.BT1A1_1076	1.146e-10	70.0	COG2834@1|root,COG2834@2|Bacteria,1TR96@1239|Firmicutes,4HEBB@91061|Bacilli,1ZDX6@1386|Bacillus	91061|Bacilli	M	COG2834 Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092,LolA_like,MucB_RseB
TLS2_k127_4910595_2	1267535.KB906767_gene3789	6.659e-56	202.0	COG0558@1|root,COG0558@2|Bacteria,3Y427@57723|Acidobacteria,2JID7@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_4911436_1	1267535.KB906767_gene230	3.798e-83	287.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	AXE1,Peptidase_S9
TLS2_k127_4911436_2	76114.ebA362	2.34e-64	239.0	COG3540@1|root,COG3540@2|Bacteria,1NE6K@1224|Proteobacteria,2WBDQ@28216|Betaproteobacteria,2KY4F@206389|Rhodocyclales	206389|Rhodocyclales	P	PhoD-like phosphatase	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD
TLS2_k127_4911436_3	1121123.AUAO01000001_gene966	8.562e-20	90.0	COG3360@1|root,COG3360@2|Bacteria,1N6YT@1224|Proteobacteria,2UFPQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
TLS2_k127_4911436_0	443143.GM18_2405	0.0	1186.0	COG0296@1|root,COG0296@2|Bacteria,1R5YG@1224|Proteobacteria,42S89@68525|delta/epsilon subdivisions,2WNNP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Alpha amylase, C-terminal all-beta domain	-	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TLS2_k127_491469_0	1403819.BATR01000020_gene706	3.235e-91	313.0	COG0527@1|root,COG0527@2|Bacteria,46SIS@74201|Verrucomicrobia,2ITJM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Amino acid kinase family	-	-	-	-	-	-	-	-	-	-	-	-	AA_kinase
TLS2_k127_491469_1	1128427.KB904821_gene174	4.914e-67	237.0	COG0705@1|root,COG0705@2|Bacteria,1G5IY@1117|Cyanobacteria,1HF1W@1150|Oscillatoriales	1117|Cyanobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS2_k127_491469_2	926569.ANT_15900	3.839e-25	117.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS2_k127_491741_0	1267535.KB906767_gene4711	8.349e-73	255.0	COG4932@1|root,COG4932@2|Bacteria,3Y6EM@57723|Acidobacteria,2JKUS@204432|Acidobacteriia	204432|Acidobacteriia	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_491741_1	1267535.KB906767_gene2855	1.022e-65	236.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,OmpA,Plug,RHS_repeat,TonB_dep_Rec
TLS2_k127_491741_3	1267535.KB906767_gene2855	6.34e-17	82.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,OmpA,Plug,RHS_repeat,TonB_dep_Rec
TLS2_k127_491741_2	1267535.KB906767_gene1082	4.216e-18	87.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,OmpA,Plug,RHS_repeat,TonB_dep_Rec
TLS2_k127_4917880_0	1121904.ARBP01000003_gene6496	7.792e-244	774.0	COG0308@1|root,COG0308@2|Bacteria,4NGTZ@976|Bacteroidetes,47MWS@768503|Cytophagia	976|Bacteroidetes	E	Peptidase family M1 domain	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
TLS2_k127_4917880_1	452637.Oter_1909	1.846e-37	149.0	COG3595@1|root,COG3595@2|Bacteria,46W0J@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_4919368_4	404589.Anae109_4241	7.327e-82	280.0	COG1765@1|root,COG1765@2|Bacteria,1RBJN@1224|Proteobacteria,43AKT@68525|delta/epsilon subdivisions,2X60V@28221|Deltaproteobacteria,2Z23B@29|Myxococcales	28221|Deltaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_4919368_0	404589.Anae109_4240	5.828e-168	537.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,437TD@68525|delta/epsilon subdivisions,2WT6I@28221|Deltaproteobacteria,2YX1E@29|Myxococcales	28221|Deltaproteobacteria	C	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS2_k127_4919368_1	404589.Anae109_4239	1.295e-131	430.0	COG0654@1|root,COG0654@2|Bacteria,1R03K@1224|Proteobacteria,43CQQ@68525|delta/epsilon subdivisions,2X7Y6@28221|Deltaproteobacteria,2Z1K0@29|Myxococcales	28221|Deltaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS2_k127_4919368_3	555779.Dthio_PD0621	1.555e-86	304.0	COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,430WE@68525|delta/epsilon subdivisions,2WVBQ@28221|Deltaproteobacteria,2M8Y3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3,PAS_9
TLS2_k127_4919368_5	118168.MC7420_4864	1.868e-47	178.0	COG1776@1|root,COG1776@2|Bacteria,1G5NU@1117|Cyanobacteria,1HB75@1150|Oscillatoriales	1117|Cyanobacteria	NT	Chemotaxis protein CheC, inhibitor of MCP methylation	-	-	-	ko:K03410	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheC
TLS2_k127_4919368_6	679926.Mpet_1207	8.425e-30	123.0	COG0784@1|root,arCOG02391@2157|Archaea	2157|Archaea	T	response regulator, receiver	cheY	-	-	ko:K02658,ko:K03413	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
TLS2_k127_4919368_2	1191523.MROS_0114	5.35e-99	336.0	COG2273@1|root,COG2273@2|Bacteria	2|Bacteria	G	xyloglucan:xyloglucosyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,CBM_6,F5_F8_type_C,Glyco_hydro_16,SLH
TLS2_k127_4952738_1	1123504.JQKD01000012_gene1238	4.913e-44	164.0	COG1848@1|root,COG1848@2|Bacteria,1RK9K@1224|Proteobacteria	1224|Proteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_4952738_3	649638.Trad_1394	7.981e-12	68.0	COG3905@1|root,COG3905@2|Bacteria	2|Bacteria	K	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source	vapB43	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0071944	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	RHH_1
TLS2_k127_4952738_0	742725.HMPREF9450_01036	9.722e-132	439.0	COG1874@1|root,COG1874@2|Bacteria,4PC2I@976|Bacteroidetes,2FZW2@200643|Bacteroidia	976|Bacteroidetes	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_42
TLS2_k127_4952738_2	243090.RB2092	1.119e-16	80.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_4993383_3	204669.Acid345_0362	4.72e-30	124.0	COG0664@1|root,COG0664@2|Bacteria,3Y4WU@57723|Acidobacteria,2JMTC@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_4993383_1	198094.BA_1875	7.685e-113	379.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,4HAY2@91061|Bacilli,1ZBK3@1386|Bacillus	91061|Bacilli	C	Fe-S oxidoreductases	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
TLS2_k127_4993383_0	404589.Anae109_2250	2.036e-153	507.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42PVA@68525|delta/epsilon subdivisions,2WJ10@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB-1	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
TLS2_k127_4993383_4	1173029.JH980292_gene2478	1.479e-05	50.0	COG1918@1|root,COG1918@2|Bacteria,1G9QG@1117|Cyanobacteria	1117|Cyanobacteria	P	FeoA	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
TLS2_k127_4993383_2	439292.Bsel_1309	2.177e-40	162.0	COG1138@1|root,COG1138@2|Bacteria,1UH6S@1239|Firmicutes,4HF5S@91061|Bacilli	91061|Bacilli	O	Cytochrome c	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
TLS2_k127_4995261_2	269799.Gmet_0856	3.364e-05	50.0	COG0457@1|root,COG0457@2|Bacteria,1N0Q1@1224|Proteobacteria,42TBT@68525|delta/epsilon subdivisions,2WPII@28221|Deltaproteobacteria,43V2H@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
TLS2_k127_4995261_0	479434.Sthe_0642	4.031e-125	410.0	COG0489@1|root,COG0489@2|Bacteria,2G60P@200795|Chloroflexi,27XJW@189775|Thermomicrobia	189775|Thermomicrobia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
TLS2_k127_4995261_1	671143.DAMO_1612	3.765e-101	336.0	COG0492@1|root,COG0492@2|Bacteria,2NNS7@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9,4.3.1.9	ko:K00384,ko:K03671,ko:K22345	ko00030,ko00450,ko04621,ko05418,map00030,map00450,map04621,map05418	-	R01544,R02016,R03596,R09372	RC00013,RC00544,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913,iPC815.YPO1374	Pyr_redox_2
TLS2_k127_5007061_3	159450.NH14_00535	8.147e-17	81.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2VQ3A@28216|Betaproteobacteria,1K7JP@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS2_k127_5007061_2	1303518.CCALI_00604	3.524e-37	142.0	COG2151@1|root,COG2151@2|Bacteria	2|Bacteria	L	metal-sulfur cluster biosynthetic enzyme	paaD	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
TLS2_k127_5007061_0	518766.Rmar_0598	2.58e-206	658.0	COG0449@1|root,COG0449@2|Bacteria,4NE8Q@976|Bacteroidetes,1FIV2@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
TLS2_k127_5007061_1	555079.Toce_2266	3.543e-48	185.0	COG1597@1|root,COG1597@2|Bacteria,1TQJH@1239|Firmicutes,24BHT@186801|Clostridia	186801|Clostridia	I	lipid kinase, YegS Rv2252 BmrU family	ytlR	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS2_k127_5007061_4	3656.XP_008442196.1	1.647e-11	65.0	COG3320@1|root,KOG1221@2759|Eukaryota,37IRY@33090|Viridiplantae,3G9S1@35493|Streptophyta,4JKJH@91835|fabids	35493|Streptophyta	I	Catalyzes the reduction of fatty acyl-CoA to fatty alcohols	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009555,GO:0009653,GO:0009698,GO:0009699,GO:0009987,GO:0010208,GO:0010345,GO:0010584,GO:0010927,GO:0016043,GO:0016491,GO:0016620,GO:0016627,GO:0016628,GO:0016903,GO:0019438,GO:0019637,GO:0019693,GO:0019748,GO:0022607,GO:0030198,GO:0032501,GO:0032502,GO:0032989,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035336,GO:0035337,GO:0035383,GO:0043062,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044424,GO:0044464,GO:0044550,GO:0045229,GO:0046483,GO:0048229,GO:0048646,GO:0048856,GO:0048869,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071840,GO:0072521,GO:0080019,GO:0085029,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901568,GO:1901576	1.2.1.84	ko:K13356	ko00073,ko04146,ko04212,map00073,map04146,map04212	-	R09470	RC00004	ko00000,ko00001,ko01000	-	-	-	NAD_binding_4,Sterile
TLS2_k127_5008252_1	1267535.KB906767_gene2296	4.258e-91	314.0	COG4585@1|root,COG4585@2|Bacteria,3Y59R@57723|Acidobacteria	2|Bacteria	T	PFAM ATP-binding region, ATPase domain protein domain protein	-	-	2.7.13.3	ko:K07683	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF_2,HATPase_c,HisKA_3,PAS,PAS_9,Pkinase
TLS2_k127_5008252_2	234267.Acid_1603	2.268e-85	288.0	COG2197@1|root,COG2197@2|Bacteria,3Y6T2@57723|Acidobacteria	57723|Acidobacteria	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_5008252_0	869210.Marky_1927	3.192e-149	482.0	COG0076@1|root,COG0076@2|Bacteria,1WKXN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	COG0076 Glutamate decarboxylase and related PLP-dependent	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS2_k127_5010009_7	1123008.KB905694_gene1719	1.037e-12	72.0	COG0500@1|root,COG2226@2|Bacteria,4NEUC@976|Bacteroidetes,2FPEJ@200643|Bacteroidia,22YY7@171551|Porphyromonadaceae	976|Bacteroidetes	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	arsM	-	2.1.1.137,2.1.1.79	ko:K00574,ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_31
TLS2_k127_5010009_1	247490.KSU1_C1712	2.054e-122	410.0	2DBP2@1|root,2ZA71@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5010009_2	411476.BACOVA_02061	4.023e-100	340.0	COG3858@1|root,COG3858@2|Bacteria	2|Bacteria	S	chitin binding	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,Glyco_hydro_18
TLS2_k127_5010009_4	452637.Oter_3915	7.063e-54	199.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31,TPMT
TLS2_k127_5010009_3	1227739.Hsw_0453	1.378e-93	325.0	COG0531@1|root,COG0531@2|Bacteria,4NH7J@976|Bacteroidetes,47NNC@768503|Cytophagia	976|Bacteroidetes	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_5010009_5	335543.Sfum_1748	5.345e-52	198.0	COG0593@1|root,COG1943@1|root,COG0593@2|Bacteria,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,42PP3@68525|delta/epsilon subdivisions,2X227@28221|Deltaproteobacteria,2MQQ2@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TLS2_k127_5010009_6	518766.Rmar_0655	2.583e-42	159.0	COG1371@1|root,COG1371@2|Bacteria	2|Bacteria	J	PFAM Archease protein family (DUF101 UPF0211)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
TLS2_k127_5010009_0	247490.KSU1_C0336	1.963e-178	573.0	COG1690@1|root,COG1690@2|Bacteria,2IWY4@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
TLS2_k127_5041359_6	1329516.JPST01000056_gene869	3.429e-21	98.0	COG1310@1|root,COG1310@2|Bacteria,1V6TY@1239|Firmicutes,4HNFX@91061|Bacilli,27D2U@186824|Thermoactinomycetaceae	91061|Bacilli	S	JAB/MPN domain	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
TLS2_k127_5041359_0	1120973.AQXL01000131_gene2136	2.892e-158	527.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,4H9WW@91061|Bacilli,27835@186823|Alicyclobacillaceae	91061|Bacilli	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
TLS2_k127_5041359_3	1297742.A176_00137	2.028e-67	237.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WMXB@28221|Deltaproteobacteria,2YUZZ@29|Myxococcales	28221|Deltaproteobacteria	L	Uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_5041359_2	1009370.ALO_13749	3.796e-83	287.0	COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,4H1WW@909932|Negativicutes	909932|Negativicutes	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
TLS2_k127_5041359_1	204669.Acid345_3776	6.314e-117	389.0	COG0452@1|root,COG0452@2|Bacteria,3Y2QJ@57723|Acidobacteria,2JIK5@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TLS2_k127_5041359_7	1267533.KB906739_gene2624	8.878e-06	51.0	COG1758@1|root,COG1758@2|Bacteria,3Y5Z6@57723|Acidobacteria,2JK65@204432|Acidobacteriia	204432|Acidobacteriia	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	-	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
TLS2_k127_5041359_4	868864.Dester_0178	1.511e-52	194.0	COG0194@1|root,COG0194@2|Bacteria,2G3ZQ@200783|Aquificae	200783|Aquificae	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
TLS2_k127_5041359_5	290397.Adeh_2607	3.386e-36	145.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,42RFR@68525|delta/epsilon subdivisions,2WJYK@28221|Deltaproteobacteria,2YVIN@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1732)	yicC	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
TLS2_k127_5043143_6	517417.Cpar_0491	1.206e-92	312.0	COG1145@1|root,COG1145@2|Bacteria,1FEGQ@1090|Chlorobi	1090|Chlorobi	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
TLS2_k127_5043143_1	452637.Oter_2972	8.762e-229	718.0	COG3669@1|root,COG3669@2|Bacteria,46Y1K@74201|Verrucomicrobia,3K8SP@414999|Opitutae	414999|Opitutae	G	PFAM glycoside hydrolase family 29	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
TLS2_k127_5043143_0	1267535.KB906767_gene4766	5.519e-291	910.0	COG1964@1|root,COG1964@2|Bacteria,3Y2WC@57723|Acidobacteria,2JHTH@204432|Acidobacteriia	204432|Acidobacteriia	S	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
TLS2_k127_5043143_5	204669.Acid345_2766	1.929e-134	436.0	COG0535@1|root,COG0535@2|Bacteria,3Y3QA@57723|Acidobacteria,2JIAZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
TLS2_k127_5043143_3	1267535.KB906767_gene5225	8.298e-201	635.0	COG0673@1|root,COG0673@2|Bacteria,3Y7B1@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_5043143_2	756272.Plabr_3138	3.912e-201	633.0	COG4806@1|root,COG4806@2|Bacteria,2IXTQ@203682|Planctomycetes	203682|Planctomycetes	G	L-rhamnose isomerase	rhaA	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008740,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019324,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575	5.3.1.14	ko:K01813	ko00051,ko01120,map00051,map01120	-	R02437	RC00434	ko00000,ko00001,ko01000	-	-	-	RhaA
TLS2_k127_5043143_4	314230.DSM3645_24165	1.32e-172	556.0	COG0591@1|root,COG0591@2|Bacteria,2IWSN@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
TLS2_k127_5049758_0	1150600.ADIARSV_0055	4.359e-242	771.0	28MHM@1|root,2ZAUH@2|Bacteria,4NKMG@976|Bacteroidetes,1IWWX@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5049758_2	5062.CADAORAP00008563	1.052e-10	72.0	COG0329@1|root,2RTV6@2759|Eukaryota,39K33@33154|Opisthokonta,3P1G4@4751|Fungi,3QP1X@4890|Ascomycota,20MIQ@147545|Eurotiomycetes	4751|Fungi	H	Belongs to the DapA family	-	-	-	-	-	-	-	-	-	-	-	-	DHDPS
TLS2_k127_5053134_1	1122604.JONR01000025_gene4602	2.94e-100	350.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS2_k127_5053134_0	926554.KI912671_gene275	8.562e-117	388.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta
TLS2_k127_5058650_0	234267.Acid_7007	4.569e-167	537.0	COG1649@1|root,COG1649@2|Bacteria	2|Bacteria	F	PFAM Uncharacterised BCR, COG1649	-	-	-	-	-	-	-	-	-	-	-	-	GHL10,GHL6,Glyco_hydro_42M,Polysacc_deac_1
TLS2_k127_5059563_9	234267.Acid_7690	1.242e-53	204.0	COG3712@1|root,COG3712@2|Bacteria,3Y772@57723|Acidobacteria	57723|Acidobacteria	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
TLS2_k127_5059563_3	234267.Acid_7689	1.463e-129	422.0	COG1131@1|root,COG1131@2|Bacteria,3Y6U6@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_5059563_11	33876.JNXY01000006_gene934	4.534e-09	67.0	COG1277@1|root,COG1277@2|Bacteria,2GKKP@201174|Actinobacteria,4D8U0@85008|Micromonosporales	201174|Actinobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS2_k127_5059563_4	234267.Acid_7687	2.704e-124	405.0	COG1131@1|root,COG1131@2|Bacteria,3Y4YH@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_5059563_7	234267.Acid_7686	1.398e-67	240.0	2F2X8@1|root,33VSU@2|Bacteria,3Y7XB@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5059563_12	1499967.BAYZ01000036_gene2434	9.858e-09	63.0	COG2260@1|root,COG2260@2|Bacteria	2|Bacteria	J	snoRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
TLS2_k127_5059563_1	1307759.JOMJ01000003_gene894	1.897e-177	569.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,2MA96@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Glycosyl transferase, family 20	otsAB	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,S6PP,Trehalose_PPase
TLS2_k127_5059563_5	644282.Deba_2007	2.032e-118	391.0	COG2013@1|root,COG2013@2|Bacteria,1NBBE@1224|Proteobacteria,42N2E@68525|delta/epsilon subdivisions,2WJFV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24,DUF4339
TLS2_k127_5059563_0	1499967.BAYZ01000013_gene6451	1.94e-247	775.0	COG0033@1|root,COG0033@2|Bacteria,2NS5G@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	pgm	GO:0000271,GO:0003674,GO:0003824,GO:0004614,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005996,GO:0006006,GO:0006012,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0016868,GO:0019318,GO:0019320,GO:0019388,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0055114,GO:0071704,GO:1901575,GO:1901576	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1376,iECED1_1282.ECED1_0670,iECNA114_1301.ECNA114_0627,iECOK1_1307.ECOK1_0699,iECP_1309.ECP_0709,iECS88_1305.ECS88_0725,iJN678.pgm,iLF82_1304.LF82_1632,iNRG857_1313.NRG857_03110,iUMN146_1321.UM146_14115,iYL1228.KPN_00711	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_5059563_8	1122917.KB899673_gene718	2.228e-56	205.0	COG2120@1|root,COG2120@2|Bacteria,1TUFR@1239|Firmicutes,4I855@91061|Bacilli,26YXG@186822|Paenibacillaceae	91061|Bacilli	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_5059563_6	1123277.KB893174_gene6070	1.764e-85	295.0	COG0329@1|root,COG0329@2|Bacteria,4NI1I@976|Bacteroidetes,47NMJ@768503|Cytophagia	976|Bacteroidetes	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_5059563_2	234267.Acid_2258	7.026e-150	480.0	COG0329@1|root,COG0329@2|Bacteria,3Y8K6@57723|Acidobacteria	57723|Acidobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_5059563_10	234267.Acid_2257	4.076e-11	68.0	COG4577@1|root,COG4577@2|Bacteria	2|Bacteria	CQ	ethanolamine catabolic process	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
TLS2_k127_5081169_0	1047013.AQSP01000126_gene2741	1.201e-150	483.0	COG0339@1|root,COG0339@2|Bacteria,2NP9Q@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M3	prlC	-	3.4.15.5,3.4.24.70	ko:K01284,ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
TLS2_k127_5081169_1	1124780.ANNU01000049_gene2188	4.418e-117	386.0	COG0339@1|root,COG0339@2|Bacteria,4NFYA@976|Bacteroidetes,47KDS@768503|Cytophagia	976|Bacteroidetes	E	PFAM Peptidase family M3	-	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
TLS2_k127_5087926_0	671143.DAMO_1189	4.527e-89	301.0	COG1137@1|root,COG1137@2|Bacteria,2NNRT@2323|unclassified Bacteria	2|Bacteria	S	lipopolysaccharide transport protein B ATP-binding component of ABC superfamily	lptB	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K01990,ko:K06861	ko02010,map02010	M00254,M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1,3.A.1	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_5087926_1	1121918.ARWE01000001_gene1887	1.836e-43	168.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,43RYZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Sigma-54 factor, Activator interacting domain (AID)	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
TLS2_k127_5095774_1	293826.Amet_2884	2.195e-14	77.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,36DF8@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_5095774_0	204669.Acid345_3635	7.351e-126	428.0	COG0768@1|root,COG0768@2|Bacteria,3Y2XX@57723|Acidobacteria,2JHPS@204432|Acidobacteriia	204432|Acidobacteriia	M	Penicillin-binding protein, dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
TLS2_k127_5095774_2	204669.Acid345_3636	1.289e-05	53.0	COG2919@1|root,COG2919@2|Bacteria,3Y4JZ@57723|Acidobacteria,2JJBJ@204432|Acidobacteriia	204432|Acidobacteriia	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	-	-	-	-	-	-	-	-	-	-	-	-	DivIC,FtsL
TLS2_k127_5099088_1	330214.NIDE3508	2.178e-58	211.0	28N6F@1|root,2ZBBB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5099088_0	344747.PM8797T_07207	1.624e-203	640.0	COG0433@1|root,COG0433@2|Bacteria,2IY71@203682|Planctomycetes	203682|Planctomycetes	L	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87,PDDEXK_1
TLS2_k127_5106913_0	1267535.KB906767_gene1169	4.62e-206	651.0	COG1502@1|root,COG1502@2|Bacteria,3Y2GD@57723|Acidobacteria	57723|Acidobacteria	I	PLD-like domain	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
TLS2_k127_5106913_2	635013.TherJR_2929	1.281e-131	437.0	COG0591@1|root,COG0591@2|Bacteria,1TPVE@1239|Firmicutes,248NQ@186801|Clostridia,260ZM@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307,ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21,2.A.21.2	-	-	SSF
TLS2_k127_5106913_4	118163.Ple7327_4086	2.182e-24	105.0	COG3695@1|root,COG3695@2|Bacteria,1G82G@1117|Cyanobacteria,3VKCI@52604|Pleurocapsales	1117|Cyanobacteria	L	PFAM 6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
TLS2_k127_5106913_3	639030.JHVA01000001_gene3050	5.771e-88	303.0	COG1879@1|root,COG1879@2|Bacteria,3Y3RJ@57723|Acidobacteria,2JK89@204432|Acidobacteriia	2|Bacteria	K	IclR helix-turn-helix domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	HTH_IclR,LacI,Peripla_BP_4
TLS2_k127_5106913_1	234267.Acid_2974	4.238e-173	574.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_5110149_0	1340493.JNIF01000003_gene1819	1.077e-80	302.0	COG2911@1|root,COG4775@1|root,COG2911@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K07277,ko:K09800	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	AsmA_2,Bac_surface_Ag,DUF748,POTRA,TamB
TLS2_k127_5110652_1	1237149.C900_04893	4.224e-56	213.0	COG2989@1|root,COG2989@2|Bacteria,4NH3J@976|Bacteroidetes,47MU1@768503|Cytophagia	976|Bacteroidetes	T	L,D-transpeptidase catalytic domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
TLS2_k127_5110652_0	234267.Acid_5076	1.905e-75	257.0	COG3285@1|root,COG3285@2|Bacteria,3Y74I@57723|Acidobacteria	57723|Acidobacteria	L	dna ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
TLS2_k127_5118709_0	330214.NIDE1289	2.288e-238	756.0	COG0058@1|root,COG0058@2|Bacteria,3J0W1@40117|Nitrospirae	40117|Nitrospirae	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
TLS2_k127_5118709_2	886293.Sinac_4982	3.962e-94	317.0	COG1131@1|root,COG1131@2|Bacteria,2IXQV@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_5118709_1	886293.Sinac_4981	4.871e-173	561.0	COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,2IXSG@203682|Planctomycetes	203682|Planctomycetes	N	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_5,ABC_transp_aux
TLS2_k127_5125469_2	794903.OPIT5_07055	1.136e-79	269.0	COG1940@1|root,COG1940@2|Bacteria,46SBQ@74201|Verrucomicrobia	74201|Verrucomicrobia	GK	carbohydrate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5125469_0	234267.Acid_0805	3.359e-120	392.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_5125469_1	215803.DB30_0441	2.896e-94	319.0	COG1063@1|root,COG1063@2|Bacteria,1NXSN@1224|Proteobacteria,438FZ@68525|delta/epsilon subdivisions,2X3QX@28221|Deltaproteobacteria,2YWVR@29|Myxococcales	28221|Deltaproteobacteria	E	Glucose dehydrogenase C-terminus	gcd	-	-	-	-	-	-	-	-	-	-	-	ADH_N,Glu_dehyd_C
TLS2_k127_5140743_2	1168289.AJKI01000022_gene1912	5.601e-36	151.0	COG1387@1|root,COG1387@2|Bacteria,4NMBC@976|Bacteroidetes,2FNU7@200643|Bacteroidia	976|Bacteroidetes	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_5140743_3	661478.OP10G_2205	2.712e-15	90.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179,ko:K13276	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH5,GH9	-	Cellulase,F5_F8_type_C,FIVAR
TLS2_k127_5140743_0	1396418.BATQ01000141_gene3408	1.383e-91	325.0	COG1680@1|root,COG1680@2|Bacteria,46T7M@74201|Verrucomicrobia,2IWEF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_5140743_1	1297569.MESS2_1000038	1.374e-46	178.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,43PQD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Ubie_methyltran
TLS2_k127_5146337_0	1382359.JIAL01000001_gene136	5.072e-175	561.0	COG1674@1|root,COG1674@2|Bacteria,3Y3CJ@57723|Acidobacteria,2JHRN@204432|Acidobacteriia	204432|Acidobacteriia	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TLS2_k127_5146337_1	234267.Acid_6217	1.713e-37	149.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
TLS2_k127_5146426_0	1267535.KB906767_gene3934	1.225e-107	376.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,3Y79C@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
TLS2_k127_5147370_1	761193.Runsl_2422	7.295e-139	448.0	2DBK2@1|root,2Z9Q1@2|Bacteria,4NET4@976|Bacteroidetes,47MUQ@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5147370_0	1499967.BAYZ01000172_gene5770	9.725e-197	630.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS2_k127_5147370_2	1499967.BAYZ01000076_gene780	2.054e-84	286.0	COG0191@1|root,COG0191@2|Bacteria	2|Bacteria	G	fructose-bisphosphate aldolase activity	-	-	4.1.2.13,4.1.2.40	ko:K01624,ko:K08302	ko00010,ko00030,ko00051,ko00052,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01069,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
TLS2_k127_5149571_1	1123400.KB904769_gene2782	1.961e-43	177.0	COG4191@1|root,COG4191@2|Bacteria,1R969@1224|Proteobacteria	1224|Proteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_8
TLS2_k127_5149571_0	1123242.JH636434_gene5289	1.248e-175	563.0	COG0673@1|root,COG0673@2|Bacteria,2IX34@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_5150431_0	1434325.AZQN01000002_gene1123	3.05e-204	653.0	COG1053@1|root,COG1053@2|Bacteria,4NG03@976|Bacteroidetes,47TC7@768503|Cytophagia	976|Bacteroidetes	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_5150431_1	1259795.ARJK01000002_gene197	1.136e-28	119.0	COG0745@1|root,COG0745@2|Bacteria,1UP7E@1239|Firmicutes,25H7U@186801|Clostridia	186801|Clostridia	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_5150431_2	1031288.AXAA01000001_gene2392	6.751e-20	97.0	COG1776@1|root,COG1776@2|Bacteria,1UNKB@1239|Firmicutes,247MX@186801|Clostridia,36H30@31979|Clostridiaceae	186801|Clostridia	NT	chemotaxis protein	cheC	-	-	ko:K03410	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheC
TLS2_k127_5155087_0	926569.ANT_15980	3.342e-70	250.0	28T1C@1|root,2ZFAN@2|Bacteria,2G9NB@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5155087_1	926569.ANT_15970	2.385e-42	158.0	COG0782@1|root,COG0782@2|Bacteria,2G6U9@200795|Chloroflexi	200795|Chloroflexi	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TLS2_k127_517935_2	382464.ABSI01000014_gene1462	3.006e-55	209.0	COG3934@1|root,COG3934@2|Bacteria,46Z5X@74201|Verrucomicrobia,2IWQJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_517935_1	861299.J421_6088	5.135e-134	451.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_517935_0	1265505.ATUG01000002_gene1648	4.096e-166	531.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2MI40@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_5185974_0	1232410.KI421418_gene2147	3.972e-286	889.0	COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,42MGH@68525|delta/epsilon subdivisions,2WK72@28221|Deltaproteobacteria,43S83@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon_1	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS2_k127_5185974_2	234267.Acid_3335	1.706e-56	202.0	COG2764@1|root,COG2764@2|Bacteria,3Y4WV@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_5185974_1	886293.Sinac_3494	3.955e-97	331.0	COG0500@1|root,COG4742@1|root,COG2226@2|Bacteria,COG4742@2|Bacteria,2IXEP@203682|Planctomycetes	203682|Planctomycetes	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
TLS2_k127_5185974_3	264732.Moth_2006	8.401e-48	177.0	COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,24AHV@186801|Clostridia	186801|Clostridia	O	XanTHIne and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS2_k127_5195843_0	584708.Apau_0555	4.833e-49	189.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	2.3.1.128,2.3.1.82	ko:K00663,ko:K03790	-	-	-	-	ko00000,ko01000,ko01504,ko03009	-	-	-	Acetyltransf_3
TLS2_k127_5195843_1	1395513.P343_15280	1.446e-47	184.0	COG1247@1|root,COG1247@2|Bacteria,1V6X5@1239|Firmicutes,4HGYP@91061|Bacilli,26NZ3@186821|Sporolactobacillaceae	91061|Bacilli	M	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
TLS2_k127_5195843_2	1146883.BLASA_1309	1.265e-31	128.0	2E4PM@1|root,32P93@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5195843_3	639030.JHVA01000001_gene3678	1.542e-27	129.0	COG4447@1|root,COG4447@2|Bacteria,3Y2MX@57723|Acidobacteria	57723|Acidobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5199994_0	1121904.ARBP01000013_gene407	1.093e-132	443.0	COG4409@1|root,COG5276@1|root,COG4409@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	3.2.1.18,3.2.1.4	ko:K01179,ko:K01186	ko00500,ko00511,ko00600,ko01100,ko04142,map00500,map00511,map00600,map01100,map04142	-	R04018,R06200,R11307,R11308	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33,GH5,GH9	-	BNR_2,BNR_3,CelD_N,Dockerin_1,Glyco_hydro_9,Laminin_G_3,TSP_3
TLS2_k127_5199994_1	452637.Oter_3156	1.578e-05	52.0	COG0577@1|root,COG0577@2|Bacteria,46UW2@74201|Verrucomicrobia	74201|Verrucomicrobia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_5212775_2	1408473.JHXO01000013_gene531	1.245e-38	152.0	COG0175@1|root,COG0175@2|Bacteria,4NGVI@976|Bacteroidetes,2FPGR@200643|Bacteroidia	976|Bacteroidetes	EH	Reduction of activated sulfate into sulfite	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TLS2_k127_5212775_0	452637.Oter_1839	9.222e-269	840.0	COG5492@1|root,COG5492@2|Bacteria,46UXF@74201|Verrucomicrobia,3K8Z6@414999|Opitutae	414999|Opitutae	N	Putative collagen-binding domain of a collagenase	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF5060
TLS2_k127_5212775_1	575540.Isop_0606	1.753e-40	159.0	COG1413@1|root,COG1413@2|Bacteria,2J0ZX@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_5213613_0	1123023.JIAI01000002_gene4757	1.421e-208	685.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4E0K4@85010|Pseudonocardiales	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349,ko:K17641	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
TLS2_k127_5213613_1	1123248.KB893359_gene2154	2.331e-91	336.0	COG0726@1|root,COG0726@2|Bacteria,4NJK7@976|Bacteroidetes	976|Bacteroidetes	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_5213613_3	1173026.Glo7428_2145	2.757e-23	106.0	COG2730@1|root,COG2730@2|Bacteria,1G7EB@1117|Cyanobacteria	1117|Cyanobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase
TLS2_k127_5213613_2	1191523.MROS_0856	1.536e-59	213.0	COG2606@1|root,COG2606@2|Bacteria	2|Bacteria	S	Cys-tRNA(Pro) hydrolase activity	-	-	-	ko:K03976,ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
TLS2_k127_5213613_4	298653.Franean1_4075	5.587e-13	76.0	COG4454@1|root,COG4454@2|Bacteria,2GS6Z@201174|Actinobacteria,4EWRZ@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
TLS2_k127_5214170_0	926569.ANT_11030	2.851e-246	774.0	COG1449@1|root,COG4945@1|root,COG1449@2|Bacteria,COG4945@2|Bacteria	2|Bacteria	G	C-terminal binding-module, SLH-like, of glucodextranase	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,Glucodextran_C,Glyco_hydro_57
TLS2_k127_5218074_1	1304880.JAGB01000002_gene2198	1.31e-165	549.0	COG1874@1|root,COG1874@2|Bacteria,1TT9J@1239|Firmicutes,24CY9@186801|Clostridia	186801|Clostridia	G	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
TLS2_k127_5218074_3	641524.ADICYQ_3837	5.863e-17	96.0	28MHM@1|root,2ZAUH@2|Bacteria,4NKMG@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5218074_2	443143.GM18_0528	1.388e-41	162.0	COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,42SID@68525|delta/epsilon subdivisions,2WQ86@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	transcriptional regulator	nikR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
TLS2_k127_5218074_0	903818.KI912268_gene1643	2.795e-213	682.0	COG4206@1|root,COG4206@2|Bacteria	2|Bacteria	H	cobalamin-transporting ATPase activity	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TLS2_k127_522157_1	1297865.APJD01000005_gene3779	2.517e-81	278.0	COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,1PS9M@1224|Proteobacteria,2V4GN@28211|Alphaproteobacteria,3JWNE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,GFO_IDH_MocA
TLS2_k127_522157_3	1123371.ATXH01000042_gene799	0.0006991	51.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_522157_0	289376.THEYE_A1789	1.837e-81	284.0	COG2723@1|root,COG2723@2|Bacteria	2|Bacteria	G	beta-glucosidase activity	bglB	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
TLS2_k127_5225226_0	204669.Acid345_1388	1.28e-96	327.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria,2JIG9@204432|Acidobacteriia	57723|Acidobacteria	T	response regulator, receiver	-	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_5225226_1	204669.Acid345_1389	7.599e-77	278.0	COG3852@1|root,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_8
TLS2_k127_5225226_2	204669.Acid345_1390	2.456e-53	192.0	COG1459@1|root,COG1459@2|Bacteria,3Y2X8@57723|Acidobacteria,2JHIX@204432|Acidobacteriia	2|Bacteria	NU	PFAM Type II secretion system F domain	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
TLS2_k127_5228623_6	903818.KI912269_gene100	8.856e-81	276.0	COG0160@1|root,COG0160@2|Bacteria,3Y3P2@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_5228623_2	1267535.KB906767_gene4734	6.78e-155	502.0	COG0215@1|root,COG0215@2|Bacteria,3Y2PW@57723|Acidobacteria,2JHIQ@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
TLS2_k127_5228623_7	484770.UFO1_0157	1.154e-53	208.0	COG1807@1|root,COG1807@2|Bacteria,1UY16@1239|Firmicutes,4H35V@909932|Negativicutes	909932|Negativicutes	M	dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_5228623_0	1267535.KB906767_gene2727	1.341e-245	769.0	COG0459@1|root,COG0459@2|Bacteria,3Y37I@57723|Acidobacteria,2JIV1@204432|Acidobacteriia	204432|Acidobacteriia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS2_k127_5228623_8	1382359.JIAL01000001_gene1679	1.889e-37	144.0	COG0234@1|root,COG0234@2|Bacteria,3Y4VQ@57723|Acidobacteria,2JJEF@204432|Acidobacteriia	204432|Acidobacteriia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TLS2_k127_5228623_3	1123371.ATXH01000013_gene1529	1.051e-118	390.0	COG0152@1|root,COG0152@2|Bacteria,2GH07@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
TLS2_k127_5228623_10	933262.AXAM01000125_gene3208	7.464e-10	67.0	COG1286@1|root,COG1286@2|Bacteria,1RJE1@1224|Proteobacteria,42SCW@68525|delta/epsilon subdivisions,2WPNX@28221|Deltaproteobacteria,2MKBI@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
TLS2_k127_5228623_11	1267533.KB906736_gene991	7.443e-08	57.0	COG3829@1|root,COG3829@2|Bacteria,3Y5JE@57723|Acidobacteria,2JJZ2@204432|Acidobacteriia	204432|Acidobacteriia	KT	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8
TLS2_k127_5228623_1	1340493.JNIF01000003_gene3012	7.777e-160	547.0	COG1196@1|root,COG1196@2|Bacteria,3Y2W1@57723|Acidobacteria	57723|Acidobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
TLS2_k127_5228623_9	767029.HMPREF9154_1014	1.588e-10	72.0	COG1073@1|root,COG1073@2|Bacteria,2I9HJ@201174|Actinobacteria,4DSUU@85009|Propionibacteriales	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071944,GO:0075136	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
TLS2_k127_5228623_4	234267.Acid_0264	2.118e-112	385.0	COG1044@1|root,COG1044@2|Bacteria,3Y4K5@57723|Acidobacteria	57723|Acidobacteria	M	SpoIVB peptidase S55	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S55
TLS2_k127_5228623_5	1047013.AQSP01000140_gene2528	3.889e-83	299.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114,DUF4347,DUF5122,LRR_5
TLS2_k127_5234307_4	1267535.KB906767_gene806	7.073e-64	229.0	COG1629@1|root,COG4771@2|Bacteria	1267535.KB906767_gene806|-	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5234307_0	1267535.KB906767_gene337	2.659e-163	536.0	COG4289@1|root,COG4289@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2264)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2264
TLS2_k127_5234307_3	234267.Acid_2678	3.66e-118	393.0	COG1940@1|root,COG1940@2|Bacteria,3Y3B2@57723|Acidobacteria	57723|Acidobacteria	GK	PFAM ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
TLS2_k127_5234307_1	742727.HMPREF9447_02705	1.915e-129	426.0	COG3507@1|root,COG3507@2|Bacteria,4P1IB@976|Bacteroidetes,2FQ19@200643|Bacteroidia,4AQAG@815|Bacteroidaceae	976|Bacteroidetes	G	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Glyco_hydro_43
TLS2_k127_5254255_1	1232410.KI421422_gene2032	1.902e-192	614.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,43SYW@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS2_k127_5254255_0	671143.DAMO_2945	3.655e-309	967.0	COG0188@1|root,COG0188@2|Bacteria,2NNNR@2323|unclassified Bacteria	2|Bacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS2_k127_5254255_2	316067.Geob_0131	6.702e-05	53.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,42TV7@68525|delta/epsilon subdivisions,2WRW0@28221|Deltaproteobacteria,43TY1@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6,YkuD
TLS2_k127_5258027_2	404589.Anae109_2629	2.168e-38	154.0	COG2244@1|root,COG2244@2|Bacteria,1RBRH@1224|Proteobacteria,42RDE@68525|delta/epsilon subdivisions,2WN1G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
TLS2_k127_5258027_0	1125973.JNLC01000010_gene1945	5.658e-95	326.0	COG0438@1|root,COG0438@2|Bacteria,1R46I@1224|Proteobacteria,2U2VZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
TLS2_k127_5258027_1	313624.NSP_23150	3.097e-44	168.0	COG0438@1|root,COG0438@2|Bacteria,1G2XD@1117|Cyanobacteria,1HPC2@1161|Nostocales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_5259921_5	1049564.TevJSym_av00480	1.852e-96	325.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria,1J5K9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031668,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
TLS2_k127_5259921_7	398512.JQKC01000014_gene1636	6.233e-27	117.0	COG1520@1|root,COG2730@1|root,COG3266@1|root,COG1520@2|Bacteria,COG2730@2|Bacteria,COG3266@2|Bacteria,1VUWZ@1239|Firmicutes,250CK@186801|Clostridia,3WP8G@541000|Ruminococcaceae	186801|Clostridia	E	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
TLS2_k127_5259921_1	1499967.BAYZ01000019_gene6275	3.376e-127	418.0	COG1472@1|root,COG1472@2|Bacteria,2NNZB@2323|unclassified Bacteria	2|Bacteria	G	Glycoside hydrolase family 3 domain protein	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
TLS2_k127_5259921_0	1499967.BAYZ01000182_gene4451	6.447e-144	469.0	COG1109@1|root,COG1109@2|Bacteria,2NNM3@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	glmM	-	5.4.2.10,5.4.2.2,5.4.2.8	ko:K01840,ko:K03431,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R02060,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_5259921_3	1499967.BAYZ01000182_gene4451	2.892e-106	361.0	COG1109@1|root,COG1109@2|Bacteria,2NNM3@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	glmM	-	5.4.2.10,5.4.2.2,5.4.2.8	ko:K01840,ko:K03431,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R02060,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_5259921_2	661478.OP10G_0988	2.228e-123	410.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	mdsC	-	2.7.1.162,2.7.1.39	ko:K02204,ko:K13059	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771,R08962	RC00002,RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
TLS2_k127_5259921_4	756067.MicvaDRAFT_2615	7.461e-103	343.0	COG1234@1|root,COG1234@2|Bacteria,1G16X@1117|Cyanobacteria,1H9GB@1150|Oscillatoriales	1117|Cyanobacteria	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
TLS2_k127_5259921_6	595460.RRSWK_06305	3.547e-41	156.0	COG3963@1|root,COG3963@2|Bacteria,2IZWV@203682|Planctomycetes	203682|Planctomycetes	I	Methyltransferase domain	-	-	2.1.1.344	ko:K22309	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_25
TLS2_k127_5265201_2	1279009.ADICEAN_00035	1.276e-10	67.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,Malectin
TLS2_k127_5265201_0	1120950.KB892756_gene6656	2.954e-139	452.0	COG1312@1|root,COG1312@2|Bacteria,2H319@201174|Actinobacteria,4DS9M@85009|Propionibacteriales	201174|Actinobacteria	G	Catalyzes the dehydration of D-mannonate	uxuA	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
TLS2_k127_5265201_1	1458357.BG58_16195	1.621e-49	182.0	COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,2VQUA@28216|Betaproteobacteria,1K6XY@119060|Burkholderiaceae	28216|Betaproteobacteria	KT	SMART metal-dependent phosphohydrolase, HD region	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	HD_4
TLS2_k127_5269086_2	234267.Acid_6247	1.521e-78	277.0	COG0673@1|root,COG0673@2|Bacteria,3Y39X@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_5269086_1	1005048.CFU_1088	1.237e-93	323.0	COG0644@1|root,COG0644@2|Bacteria,1PQI2@1224|Proteobacteria,2VUCT@28216|Betaproteobacteria	28216|Betaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS2_k127_5269086_0	1278073.MYSTI_01766	1.452e-114	393.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_5271180_7	1122927.KB895417_gene2960	2.957e-40	153.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	DUF4091,Peptidase_C25,Peptidase_M43
TLS2_k127_5271180_2	661478.OP10G_1321	9.846e-146	487.0	COG3525@1|root,COG3525@2|Bacteria	2|Bacteria	G	beta-N-acetylhexosaminidase activity	nahA	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	CHB_HEX_C_1,Glyco_hydro_20,Glyco_hydro_20b
TLS2_k127_5271180_6	1267535.KB906767_gene5149	4.598e-42	159.0	COG1652@1|root,COG1652@2|Bacteria,3Y84E@57723|Acidobacteria	57723|Acidobacteria	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
TLS2_k127_5271180_4	1379270.AUXF01000001_gene2605	1.051e-102	347.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5271180_3	452637.Oter_2993	4.333e-139	456.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K03292,ko:K16248	-	-	-	-	ko00000,ko02000	2.A.2	-	-	MFS_2,MFS_3
TLS2_k127_5271180_0	316274.Haur_0891	1.481e-162	516.0	COG2152@1|root,COG2152@2|Bacteria,2G6ZE@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycosidase PH1107-related	-	-	2.4.1.319,2.4.1.320,2.4.1.339,2.4.1.340	ko:K18785,ko:K20885	-	-	R10811,R10829,R11397,R11398	RC00049,RC02748	ko00000,ko01000	-	GH130	-	Glyco_hydro_130
TLS2_k127_5271180_1	1195236.CTER_3551	2.96e-146	471.0	COG2152@1|root,COG2152@2|Bacteria,1TYI2@1239|Firmicutes,25DIW@186801|Clostridia	186801|Clostridia	G	PFAM glycosidase, PH1107-related	-	-	2.4.1.339,2.4.1.340	ko:K20885	-	-	R11397,R11398	RC00049,RC02748	ko00000,ko01000	-	GH130	-	Glyco_hydro_130
TLS2_k127_5271180_5	682795.AciX8_3247	1.708e-50	188.0	COG5616@1|root,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TPR_8,TolB_N,Trans_reg_C
TLS2_k127_5273074_1	1267535.KB906767_gene3883	2.937e-113	370.0	COG2060@1|root,COG2060@2|Bacteria,3Y2YP@57723|Acidobacteria,2JIFM@204432|Acidobacteriia	204432|Acidobacteriia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
TLS2_k127_5273074_0	1267535.KB906767_gene3882	0.0	1033.0	COG2216@1|root,COG2216@2|Bacteria,3Y302@57723|Acidobacteria,2JHQI@204432|Acidobacteriia	204432|Acidobacteriia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
TLS2_k127_5273074_2	1267535.KB906767_gene3881	2.849e-58	208.0	COG2156@1|root,COG2156@2|Bacteria,3Y49M@57723|Acidobacteria,2JJ0W@204432|Acidobacteriia	204432|Acidobacteriia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
TLS2_k127_5273074_3	1267535.KB906767_gene3886	4.119e-38	148.0	COG0642@1|root,COG2205@2|Bacteria,3Y33Y@57723|Acidobacteria,2JHWF@204432|Acidobacteriia	1267535.KB906767_gene3886|-	T	Osmosensitive K channel His kinase sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5274660_1	1123242.JH636435_gene3013	1.471e-84	291.0	COG0673@1|root,COG0673@2|Bacteria,2IYHX@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_5274660_0	525904.Tter_0451	1.071e-99	337.0	COG0300@1|root,COG0300@2|Bacteria,2NQSH@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_527510_1	1173026.Glo7428_3987	4.371e-119	394.0	COG0859@1|root,COG0859@2|Bacteria,1G3CU@1117|Cyanobacteria	1117|Cyanobacteria	M	glycosyl transferase, family 9	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
TLS2_k127_527510_0	926549.KI421517_gene1530	2.113e-150	488.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,47JNX@768503|Cytophagia	976|Bacteroidetes	S	PFAM Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_527510_2	395961.Cyan7425_1902	5.313e-70	246.0	COG1028@1|root,COG1028@2|Bacteria,1G2UM@1117|Cyanobacteria	1117|Cyanobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_527510_3	234267.Acid_4033	2.897e-07	61.0	COG2304@1|root,COG2304@2|Bacteria,3Y3DR@57723|Acidobacteria	57723|Acidobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5277832_3	1340493.JNIF01000003_gene2715	1.409e-67	241.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	salY	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_5277832_1	671143.DAMO_3054	2.5e-111	370.0	COG5621@1|root,COG5621@2|Bacteria,2NPFN@2323|unclassified Bacteria	2|Bacteria	S	Lipocalin-like domain	attH	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
TLS2_k127_5277832_0	1304885.AUEY01000003_gene476	4.155e-170	555.0	COG1032@1|root,COG1032@2|Bacteria,1RJ9Z@1224|Proteobacteria,42TDD@68525|delta/epsilon subdivisions,2WPHS@28221|Deltaproteobacteria,2MK5Y@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	Radical_SAM
TLS2_k127_5277832_2	391625.PPSIR1_22466	1.195e-93	317.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,433Y1@68525|delta/epsilon subdivisions,2X41I@28221|Deltaproteobacteria,2YXYJ@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_5291572_3	234267.Acid_7680	3.694e-33	132.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_5291572_2	105559.Nwat_2930	9.498e-54	192.0	COG0614@1|root,COG0614@2|Bacteria,1N7EM@1224|Proteobacteria,1S6E7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
TLS2_k127_5291572_1	1121377.KB906402_gene3188	2.957e-56	211.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_5291572_0	1340493.JNIF01000003_gene1814	1.232e-118	422.0	COG3485@1|root,COG3485@2|Bacteria,3Y3FU@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_5293821_1	247490.KSU1_B0488	4.176e-117	391.0	COG0433@1|root,COG0561@1|root,COG0433@2|Bacteria,COG0561@2|Bacteria,2IXQK@203682|Planctomycetes	203682|Planctomycetes	S	Sucrose-6F-phosphate phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF87,Hydrolase_3
TLS2_k127_5293821_0	240016.ABIZ01000001_gene608	7.2e-135	445.0	COG0673@1|root,COG0673@2|Bacteria,46U95@74201|Verrucomicrobia,2IVCR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_53145_2	1232437.KL661965_gene3232	1.697e-09	61.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2WIXI@28221|Deltaproteobacteria,2MHW6@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
TLS2_k127_53145_0	1286106.MPL1_06869	4.214e-40	154.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,460YH@72273|Thiotrichales	72273|Thiotrichales	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
TLS2_k127_53145_1	1038859.AXAU01000023_gene828	5.198e-11	75.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2TRMX@28211|Alphaproteobacteria,3JSBY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Peptidase M16 inactive domain	MA20_05660	-	-	ko:K07263,ko:K07623	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_5317349_4	234267.Acid_6573	2.971e-21	103.0	COG0577@1|root,COG0577@2|Bacteria,3Y4J3@57723|Acidobacteria	57723|Acidobacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5317349_0	1031288.AXAA01000007_gene844	1.464e-145	477.0	COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,248DZ@186801|Clostridia,36EVZ@31979|Clostridiaceae	186801|Clostridia	T	carbon starvation protein CstA	cstA	-	-	-	-	-	-	-	-	-	-	-	CstA,CstA_5TM
TLS2_k127_5317349_5	926550.CLDAP_30620	6.702e-19	97.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I9,Peptidase_S8,TIG
TLS2_k127_5317349_1	1123054.KB907703_gene1342	3.643e-114	382.0	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,1RRGY@1236|Gammaproteobacteria,1WVVW@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
TLS2_k127_5317349_3	1379270.AUXF01000001_gene2135	1.931e-25	113.0	COG3871@1|root,COG3871@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	ydaG	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Putative_PNPOx,Pyrid_ox_like
TLS2_k127_5317349_2	234267.Acid_3246	1.587e-69	244.0	COG0673@1|root,COG0673@2|Bacteria,3Y76D@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_5340091_1	180332.JTGN01000003_gene2001	1.61e-120	396.0	COG0407@1|root,COG0407@2|Bacteria,1V5JE@1239|Firmicutes,24E5A@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TLS2_k127_5340091_0	1121012.AUKX01000016_gene3001	6.944e-175	561.0	COG0673@1|root,COG0673@2|Bacteria,4NGTW@976|Bacteroidetes,1I164@117743|Flavobacteriia,23IAD@178469|Arenibacter	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_5347458_4	204669.Acid345_2755	5.836e-18	88.0	COG1565@1|root,COG1565@2|Bacteria,3Y583@57723|Acidobacteria,2JNKN@204432|Acidobacteriia	204432|Acidobacteriia	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
TLS2_k127_5347458_5	944479.JQLX01000013_gene1384	1.93e-13	72.0	COG3071@1|root,COG3071@2|Bacteria,1N6Y8@1224|Proteobacteria,42WU5@68525|delta/epsilon subdivisions,2WSUR@28221|Deltaproteobacteria,2M7H0@213113|Desulfurellales	28221|Deltaproteobacteria	H	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
TLS2_k127_5347458_3	335543.Sfum_0500	1.945e-108	357.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,42RIR@68525|delta/epsilon subdivisions,2WP3R@28221|Deltaproteobacteria,2MSCP@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
TLS2_k127_5347458_1	1267534.KB906754_gene3139	1.517e-127	413.0	COG0074@1|root,COG0074@2|Bacteria,3Y3UX@57723|Acidobacteria,2JHSN@204432|Acidobacteriia	204432|Acidobacteriia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
TLS2_k127_5347458_0	1232410.KI421426_gene1411	1.562e-141	458.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2WJTS@28221|Deltaproteobacteria,43T89@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2261	ATP-grasp_2,Ligase_CoA
TLS2_k127_5347458_2	880072.Desac_2029	5.581e-114	377.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria,2MQW6@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	yfdZ	-	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_5347612_0	1123368.AUIS01000009_gene2498	5.085e-152	490.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,2NC80@225057|Acidithiobacillales	225057|Acidithiobacillales	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_5347612_1	56107.Cylst_6209	2.959e-44	168.0	COG2345@1|root,COG2345@2|Bacteria,1G44B@1117|Cyanobacteria,1HNC2@1161|Nostocales	1117|Cyanobacteria	K	Transcriptional regulator	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_5348626_0	1449063.JMLS01000017_gene685	1.149e-171	548.0	COG1082@1|root,COG1082@2|Bacteria,1UFEU@1239|Firmicutes	1239|Firmicutes	G	Glycosyl-hydrolase 97 C-terminal, oligomerisation	-	-	-	-	-	-	-	-	-	-	-	-	GH97_C,GH97_N,Glyco_hydro_97
TLS2_k127_5348626_2	234267.Acid_1358	3.212e-64	232.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	GntR,LacI,Peripla_BP_3
TLS2_k127_5348626_1	1382359.JIAL01000001_gene74	1.181e-73	258.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Dioxygenase_C
TLS2_k127_53505_0	240015.ACP_3297	8.434e-117	385.0	COG0138@1|root,COG0138@2|Bacteria,3Y2QI@57723|Acidobacteria,2JHSU@204432|Acidobacteriia	204432|Acidobacteriia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
TLS2_k127_53505_1	1089553.Tph_c26590	6.122e-83	282.0	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,42FD2@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
TLS2_k127_53505_3	1382359.JIAL01000001_gene2570	2.864e-19	96.0	COG3468@1|root,COG3468@2|Bacteria,3Y4NE@57723|Acidobacteria,2JJBC@204432|Acidobacteriia	204432|Acidobacteriia	MU	outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_53505_2	234267.Acid_6424	9.963e-60	234.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,3Y3VQ@57723|Acidobacteria	57723|Acidobacteria	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
TLS2_k127_5368136_2	234267.Acid_1509	1.749e-117	396.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5368136_4	716544.wcw_1070	1.149e-13	75.0	COG5548@1|root,COG5548@2|Bacteria,2JGI0@204428|Chlamydiae	204428|Chlamydiae	S	Transmembrane proteins 14C	-	-	-	-	-	-	-	-	-	-	-	-	Tmemb_14
TLS2_k127_5368136_0	515635.Dtur_0786	2.608e-169	548.0	COG1847@1|root,COG3854@1|root,COG1847@2|Bacteria,COG3854@2|Bacteria	2|Bacteria	S	ATPases associated with a variety of cellular activities	ycf45	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_30,R3H
TLS2_k127_5368136_3	1089544.KB912942_gene6136	4.317e-26	111.0	COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria,4E4P1@85010|Pseudonocardiales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
TLS2_k127_5368136_1	926549.KI421517_gene1362	1.367e-125	416.0	COG0471@1|root,COG0471@2|Bacteria,4NF52@976|Bacteroidetes,47NEH@768503|Cytophagia	976|Bacteroidetes	P	COGs COG0471 Di- and tricarboxylate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
TLS2_k127_5369072_0	443144.GM21_3706	1.29e-201	654.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	glycosyltransferase 36 associated	-	-	2.4.1.20	ko:K00702,ko:K13688	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000,ko01003	-	GH94,GT36,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
TLS2_k127_5384858_2	671143.DAMO_1044	1.132e-108	359.0	COG0761@1|root,COG0761@2|Bacteria,2NP7K@2323|unclassified Bacteria	2|Bacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4,2.7.4.25	ko:K00945,ko:K02945,ko:K03527	ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010	M00052,M00096,M00178	R00158,R00512,R01665,R05884,R08210	RC00002,RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	iIT341.HP0400,iLJ478.TM1444	LYTB,S1
TLS2_k127_5384858_3	562970.Btus_2407	1.573e-71	248.0	COG0247@1|root,COG0247@2|Bacteria,1TPFC@1239|Firmicutes,4HAKC@91061|Bacilli,27953@186823|Alicyclobacillaceae	91061|Bacilli	C	Cysteine-rich domain	lutA	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
TLS2_k127_5384858_1	234267.Acid_5762	8.788e-134	441.0	COG1139@1|root,COG1139@2|Bacteria,3Y3R8@57723|Acidobacteria	57723|Acidobacteria	C	cluster binding protein	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
TLS2_k127_5384858_4	696369.KI912183_gene1694	1.018e-11	75.0	COG1556@1|root,COG1556@2|Bacteria,1VATZ@1239|Firmicutes,24P3S@186801|Clostridia,262FK@186807|Peptococcaceae	186801|Clostridia	C	PFAM Uncharacterised ACR, YkgG family COG1556	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
TLS2_k127_5384858_0	204669.Acid345_1684	1.23e-211	668.0	COG0457@1|root,COG0457@2|Bacteria,3Y2M9@57723|Acidobacteria,2JMD8@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS2_k127_5395684_0	1267535.KB906767_gene97	2.071e-240	760.0	COG0466@1|root,COG0466@2|Bacteria,3Y2QB@57723|Acidobacteria,2JHMJ@204432|Acidobacteriia	204432|Acidobacteriia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS2_k127_5395684_3	105559.Nwat_1693	2.522e-27	115.0	COG0071@1|root,COG0071@2|Bacteria,1NPJI@1224|Proteobacteria,1SRY5@1236|Gammaproteobacteria,1X21C@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS2_k127_5395684_1	543632.JOJL01000001_gene7682	2.447e-103	342.0	COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria,4DJDN@85008|Micromonosporales	201174|Actinobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
TLS2_k127_5395684_2	886293.Sinac_2104	1.538e-44	168.0	COG1680@1|root,COG1680@2|Bacteria,2IWSV@203682|Planctomycetes	203682|Planctomycetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_5400232_1	1303518.CCALI_02202	2.397e-40	165.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_5400232_2	861299.J421_5669	0.0001502	50.0	COG5615@1|root,COG5615@2|Bacteria	2|Bacteria	L	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CopD
TLS2_k127_5400232_0	1089551.KE386572_gene4426	1.734e-54	208.0	COG3379@1|root,COG3379@2|Bacteria,1NBJ6@1224|Proteobacteria,2U12I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_5401422_3	435591.BDI_0261	5.413e-06	55.0	COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,4NFGR@976|Bacteroidetes,2FMDB@200643|Bacteroidia,22VVG@171551|Porphyromonadaceae	976|Bacteroidetes	E	homoserine dehydrogenase	thrA	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
TLS2_k127_5401422_1	485916.Dtox_2307	7.935e-43	166.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,261GN@186807|Peptococcaceae	186801|Clostridia	T	PFAM Protein phosphatase 2C	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
TLS2_k127_5401422_2	880073.Calab_3205	1.265e-31	130.0	2CA4A@1|root,32RQK@2|Bacteria,2NPW6@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF4416)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4416
TLS2_k127_5401422_0	1128421.JAGA01000002_gene1815	6.911e-177	570.0	COG0272@1|root,COG0272@2|Bacteria,2NNSW@2323|unclassified Bacteria	2|Bacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
TLS2_k127_5404581_0	379066.GAU_0008	2.589e-117	384.0	COG0515@1|root,COG0515@2|Bacteria,1ZT9E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_5404581_1	861299.J421_1146	2.606e-100	337.0	COG0642@1|root,COG2205@2|Bacteria	861299.J421_1146|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5404581_3	861299.J421_1145	6.133e-60	212.0	COG0461@1|root,COG0461@2|Bacteria,1ZTMR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
TLS2_k127_5404581_2	861299.J421_1142	1.904e-81	282.0	COG2207@1|root,COG2207@2|Bacteria,1ZTPX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS2_k127_5406156_1	1504823.CCMM01000008_gene964	1.114e-189	601.0	COG0148@1|root,COG0148@2|Bacteria,2NNKW@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TLS2_k127_5406156_2	1184609.KILIM_069_00290	4.238e-07	58.0	COG1366@1|root,COG1366@2|Bacteria,2HPDK@201174|Actinobacteria,4F787@85018|Dermatophilaceae	201174|Actinobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS
TLS2_k127_5406156_0	1519464.HY22_06785	4.575e-203	647.0	COG3808@1|root,COG3808@2|Bacteria,1FD6P@1090|Chlorobi	1090|Chlorobi	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS2_k127_5413898_0	1382359.JIAL01000001_gene3021	3.477e-159	514.0	COG5520@1|root,COG5520@2|Bacteria,3Y3UR@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the glycosyl hydrolase 30 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_30,Glyco_hydro_30C
TLS2_k127_5413898_1	1267535.KB906767_gene1411	5.809e-74	263.0	COG1506@1|root,COG1506@2|Bacteria,3Y357@57723|Acidobacteria,2JIKY@204432|Acidobacteriia	204432|Acidobacteriia	E	Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
TLS2_k127_5422165_13	518766.Rmar_1528	5.846e-22	100.0	2BXG3@1|root,2Z82R@2|Bacteria,4NI3Z@976|Bacteroidetes	976|Bacteroidetes	S	tagaturonate epimerase	-	-	5.1.2.7	ko:K21619	ko00040,ko01100,map00040,map01100	-	R11624	-	ko00000,ko00001,ko01000	-	-	-	UxaE
TLS2_k127_5422165_7	1379698.RBG1_1C00001G1666	7.706e-92	309.0	COG1136@1|root,COG1136@2|Bacteria,2NPA8@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_5422165_10	234267.Acid_1656	2.279e-83	290.0	COG0845@1|root,COG0845@2|Bacteria,3Y50Z@57723|Acidobacteria	57723|Acidobacteria	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TLS2_k127_5422165_5	1340493.JNIF01000003_gene2503	3.792e-96	328.0	COG0577@1|root,COG0577@2|Bacteria,3Y4C7@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_5422165_8	1267535.KB906767_gene3517	4.915e-86	298.0	COG0577@1|root,COG0577@2|Bacteria,3Y4MY@57723|Acidobacteria,2JMXU@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_5422165_1	1124780.ANNU01000071_gene1021	1.328e-170	548.0	COG2271@1|root,COG2271@2|Bacteria,4NE7R@976|Bacteroidetes,47JBJ@768503|Cytophagia	976|Bacteroidetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1,Sugar_tr
TLS2_k127_5422165_3	96561.Dole_2374	6.211e-135	436.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria,2MJ7T@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
TLS2_k127_5422165_0	498761.HM1_1471	1.116e-183	582.0	COG0538@1|root,COG0538@2|Bacteria,1UHPE@1239|Firmicutes,25F02@186801|Clostridia	186801|Clostridia	C	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_5422165_9	479434.Sthe_1638	6.695e-84	297.0	COG0624@1|root,COG0624@2|Bacteria,2G60R@200795|Chloroflexi,27Y02@189775|Thermomicrobia	189775|Thermomicrobia	E	peptidase dimerisation domain protein	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_5422165_12	370438.PTH_1800	3.323e-51	192.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,260JZ@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
TLS2_k127_5422165_11	1232410.KI421417_gene2703	2.079e-67	239.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,42RV7@68525|delta/epsilon subdivisions,2WNZT@28221|Deltaproteobacteria,43RZE@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Kinase/pyrophosphorylase	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
TLS2_k127_5422165_2	404589.Anae109_0166	2.108e-165	533.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,2YUC2@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	algC	-	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_5422165_6	760568.Desku_3301	7.667e-93	317.0	COG2222@1|root,COG2222@2|Bacteria,1TRBS@1239|Firmicutes,24A9W@186801|Clostridia,25ZZA@186807|Peptococcaceae	186801|Clostridia	G	Sugar isomerase (SIS)	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
TLS2_k127_5422165_4	1121930.AQXG01000005_gene639	2.083e-97	329.0	COG0836@1|root,COG0836@2|Bacteria,4NE1Y@976|Bacteroidetes	976|Bacteroidetes	M	mannose-1-phosphate guanylyltransferase	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_5422165_14	1379270.AUXF01000001_gene2785	8.305e-07	59.0	COG0612@1|root,COG0612@2|Bacteria,1ZSU0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_5428476_0	240015.ACP_0847	2.03e-115	378.0	COG2008@1|root,COG2008@2|Bacteria,3Y472@57723|Acidobacteria,2JIUS@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_5428476_4	234267.Acid_5311	4.381e-51	192.0	28M4B@1|root,2ZAI9@2|Bacteria,3Y3NA@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5428476_2	1232410.KI421422_gene2079	1.066e-55	203.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,42PPW@68525|delta/epsilon subdivisions,2WM1S@28221|Deltaproteobacteria,43S4Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	RadC-like JAB domain	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
TLS2_k127_5428476_1	401053.AciPR4_1016	5.647e-61	225.0	COG0524@1|root,COG0524@2|Bacteria,3Y659@57723|Acidobacteria,2JKSQ@204432|Acidobacteriia	204432|Acidobacteriia	G	pfkB family carbohydrate kinase	-	-	2.7.1.184	ko:K18478	-	-	R10970	RC00002,RC00017	ko00000,ko01000	-	-	-	PfkB
TLS2_k127_5428476_3	243231.GSU2626	2.409e-52	192.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,42M7K@68525|delta/epsilon subdivisions,2WKKM@28221|Deltaproteobacteria,43S79@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,Methyltransf_25
TLS2_k127_5433128_1	335543.Sfum_2654	3.789e-125	415.0	COG4452@1|root,COG4452@2|Bacteria,1MVVR@1224|Proteobacteria,42Q2E@68525|delta/epsilon subdivisions,2WK17@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Inner membrane protein CreD	-	-	-	ko:K06143	-	-	-	-	ko00000	-	-	-	CreD
TLS2_k127_5433128_0	234267.Acid_6969	2.591e-171	547.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TLS2_k127_5439831_2	1235793.C809_03930	4.516e-05	53.0	28Q1F@1|root,2ZCJT@2|Bacteria,1VI7R@1239|Firmicutes,24D4W@186801|Clostridia,27M4D@186928|unclassified Lachnospiraceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5439831_1	234267.Acid_4212	1.795e-20	102.0	2EQPS@1|root,33I9Q@2|Bacteria,3Y8WF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5439831_0	1195236.CTER_0372	1.69e-101	339.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia	186801|Clostridia	G	family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
TLS2_k127_544641_2	909663.KI867150_gene1480	2.089e-14	76.0	COG1578@1|root,COG1578@2|Bacteria,1RI11@1224|Proteobacteria,42RA1@68525|delta/epsilon subdivisions,2WMCD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
TLS2_k127_544641_3	1169161.KB897715_gene5467	2.042e-06	53.0	COG1028@1|root,COG1028@2|Bacteria,2IB1P@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_544641_1	700598.Niako_2668	8.486e-38	149.0	COG2318@1|root,COG2318@2|Bacteria,4NNW4@976|Bacteroidetes,1IT5S@117747|Sphingobacteriia	976|Bacteroidetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_544641_0	247490.KSU1_A0008	6.66e-44	177.0	COG4447@1|root,COG5492@1|root,COG4447@2|Bacteria,COG5492@2|Bacteria,2J3BX@203682|Planctomycetes	203682|Planctomycetes	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5453471_0	56107.Cylst_3960	1.079e-130	431.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HR5M@1161|Nostocales	1117|Cyanobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
TLS2_k127_5453471_2	880073.Calab_2556	4.853e-30	121.0	COG3251@1|root,COG3251@2|Bacteria,2NRE2@2323|unclassified Bacteria	2|Bacteria	S	MbtH-like protein	-	-	-	ko:K05375,ko:K09190	ko00261,ko01130,map00261,map01130	M00736	R10880	RC00064,RC00141,RC03296,RC03297,RC03298	ko00000,ko00001,ko00002	-	-	-	MbtH,YqcI_YcgG
TLS2_k127_5453471_1	1173027.Mic7113_1740	2.326e-100	332.0	COG3208@1|root,COG3208@2|Bacteria,1G16V@1117|Cyanobacteria,1H9TC@1150|Oscillatoriales	1117|Cyanobacteria	Q	thioesterase involved in non-ribosomal peptide biosynthesis	-	-	3.1.2.21	ko:K01071	ko00061,ko01100,map00061,map01100	-	R04014,R08157,R08158	RC00014,RC00039	ko00000,ko00001,ko01000,ko01004	-	-	-	Thioesterase
TLS2_k127_5453471_3	478741.JAFS01000001_gene1167	1.03e-12	73.0	COG3216@1|root,COG3216@2|Bacteria,46W8A@74201|Verrucomicrobia,37GQY@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Uncharacterized protein conserved in bacteria (DUF2062)	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
TLS2_k127_5456988_0	443144.GM21_3648	5.45e-219	693.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	glycosyltransferase 36 associated	-	-	2.4.1.20	ko:K00702,ko:K13688	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000,ko01003	-	GH94,GT36,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
TLS2_k127_5456988_7	1382359.JIAL01000001_gene2821	9.858e-21	104.0	COG2304@1|root,COG2304@2|Bacteria,3Y6RY@57723|Acidobacteria,2JMNT@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
TLS2_k127_5456988_4	1111069.TCCBUS3UF1_3770	3.349e-51	184.0	COG1764@1|root,COG1764@2|Bacteria,1WJVD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	redox protein regulator of disulfide bond formation	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
TLS2_k127_5456988_1	316274.Haur_2602	5.952e-119	400.0	COG0469@1|root,COG0469@2|Bacteria,2G5YE@200795|Chloroflexi,375C1@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
TLS2_k127_5456988_8	1340493.JNIF01000003_gene2006	3.617e-09	63.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	frzZ	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_5456988_5	94624.Bpet2867	6.325e-46	168.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,3T44K@506|Alcaligenaceae	28216|Betaproteobacteria	K	at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA)	glnB	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
TLS2_k127_5456988_6	1499967.BAYZ01000080_gene913	9.641e-24	111.0	2ER9F@1|root,33IV2@2|Bacteria,2NRV9@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5456988_2	1121405.dsmv_1425	2.919e-100	338.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,42MND@68525|delta/epsilon subdivisions,2WJC3@28221|Deltaproteobacteria,2MIG5@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Bacterial transferase hexapeptide (six repeats)	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
TLS2_k127_5456988_3	204669.Acid345_1131	3.048e-61	217.0	COG1960@1|root,COG1960@2|Bacteria,3Y32R@57723|Acidobacteria,2JIRM@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1,1.3.99.12	ko:K00248,ko:K09478	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_5465762_0	1191523.MROS_2623	3.762e-116	378.0	COG4124@1|root,COG4124@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 26 family	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Glyco_hydro_26
TLS2_k127_5465762_1	485917.Phep_0757	1.948e-91	308.0	COG0477@1|root,COG2814@2|Bacteria,4NE09@976|Bacteroidetes,1IP67@117747|Sphingobacteriia	976|Bacteroidetes	EGP	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	xylE	-	-	ko:K02100,ko:K03444,ko:K08138	-	-	-	-	ko00000,ko02000	2.A.1.1,2.A.1.1.2,2.A.1.1.3	-	-	Sugar_tr
TLS2_k127_5473846_0	1122605.KB893625_gene1683	1.886e-177	570.0	COG1501@1|root,COG1501@2|Bacteria,4PKHN@976|Bacteroidetes,1IP35@117747|Sphingobacteriia	976|Bacteroidetes	G	He_PIG associated, NEW1 domain of bacterial glycohydrolase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	He_PIG,He_PIG_assoc,Melibiase_2,NPCBM
TLS2_k127_5473846_1	909663.KI867150_gene2720	2.349e-102	351.0	COG0535@1|root,COG0535@2|Bacteria,1Q6NI@1224|Proteobacteria,433FI@68525|delta/epsilon subdivisions,2WXJT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_5477451_2	1122931.AUAE01000005_gene3334	1.391e-15	81.0	COG3104@1|root,COG3104@2|Bacteria,4NIIT@976|Bacteroidetes,2FR16@200643|Bacteroidia,22ZM5@171551|Porphyromonadaceae	976|Bacteroidetes	E	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_5477451_0	118168.MC7420_356	6.556e-289	903.0	COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria,1H87F@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_5477451_1	1125863.JAFN01000001_gene1760	5.873e-106	355.0	COG3581@1|root,COG3581@2|Bacteria,1PDHS@1224|Proteobacteria,43DP1@68525|delta/epsilon subdivisions	1224|Proteobacteria	I	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
TLS2_k127_5479247_5	1038858.AXBA01000011_gene1437	4.275e-25	108.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TTXX@28211|Alphaproteobacteria,3F1W5@335928|Xanthobacteraceae	28211|Alphaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	gltI	-	-	ko:K02030,ko:K10001	ko02010,ko02020,map02010,map02020	M00230,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
TLS2_k127_5479247_2	243233.MCA1291	1.186e-62	219.0	COG4803@1|root,COG4803@2|Bacteria,1RAJ2@1224|Proteobacteria,1SC6R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
TLS2_k127_5479247_4	671143.DAMO_0159	3.375e-26	114.0	2DMP9@1|root,32SV1@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3015
TLS2_k127_5479247_0	261292.Nit79A3_1335	4.529e-150	497.0	28J7E@1|root,2Z92U@2|Bacteria,1NAE1@1224|Proteobacteria,2W2SK@28216|Betaproteobacteria,372NV@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
TLS2_k127_5479247_1	1452718.JBOY01000055_gene1742	2.835e-66	237.0	COG1073@1|root,COG1073@2|Bacteria,1RFAF@1224|Proteobacteria,1S2YT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG1073 Hydrolases of the alpha beta superfamily	yfhR	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
TLS2_k127_5479247_3	1038858.AXBA01000014_gene2295	4.744e-41	153.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2TU1S@28211|Alphaproteobacteria,3F0MX@335928|Xanthobacteraceae	28211|Alphaproteobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
TLS2_k127_5489005_4	929712.KI912613_gene3939	0.0007833	48.0	COG4733@1|root,COG4733@2|Bacteria,2H7XN@201174|Actinobacteria,4CTMH@84995|Rubrobacteria	201174|Actinobacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5489005_0	1033802.SSPSH_002618	8.606e-42	169.0	COG0438@1|root,COG0438@2|Bacteria,1N1RZ@1224|Proteobacteria	1224|Proteobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
TLS2_k127_5489005_2	1187848.AJYQ01000109_gene452	2.042e-32	135.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,1XUKY@135623|Vibrionales	135623|Vibrionales	G	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress	gph	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_5489005_1	1449050.JNLE01000003_gene2465	5.806e-33	130.0	COG0425@1|root,COG0425@2|Bacteria,1V6BY@1239|Firmicutes,24JW8@186801|Clostridia	186801|Clostridia	O	Belongs to the sulfur carrier protein TusA family	yedF	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE,TusA
TLS2_k127_5489005_3	221288.JH992900_gene316	9.393e-13	77.0	COG1914@1|root,COG1914@2|Bacteria,1G4SX@1117|Cyanobacteria,1JHMK@1189|Stigonemataceae	1117|Cyanobacteria	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
TLS2_k127_5496358_0	1144275.COCOR_04693	1.014e-112	372.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,42NF8@68525|delta/epsilon subdivisions,2WKBA@28221|Deltaproteobacteria,2YXV4@29|Myxococcales	28221|Deltaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
TLS2_k127_5496358_3	1382359.JIAL01000001_gene911	3.777e-33	136.0	COG0742@1|root,COG0742@2|Bacteria,3Y4K0@57723|Acidobacteria,2JJDW@204432|Acidobacteriia	204432|Acidobacteriia	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
TLS2_k127_5496358_4	292564.Cyagr_2728	7.349e-10	73.0	COG3210@1|root,COG4995@1|root,COG3210@2|Bacteria,COG4995@2|Bacteria,1G08N@1117|Cyanobacteria,22TM9@167375|Cyanobium	1117|Cyanobacteria	U	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,PATR
TLS2_k127_5496358_5	1249997.JHZW01000002_gene790	3.268e-08	63.0	COG5662@1|root,COG5662@2|Bacteria,4PKIB@976|Bacteroidetes,1IJ9Y@117743|Flavobacteriia	976|Bacteroidetes	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5496358_6	644548.SCNU_13218	2.742e-05	54.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4GD2P@85026|Gordoniaceae	201174|Actinobacteria	K	Sigma-70, region 4	sigM	GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_5496358_1	234267.Acid_7275	1.461e-61	217.0	COG0669@1|root,COG0669@2|Bacteria,3Y4B6@57723|Acidobacteria	57723|Acidobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_5496358_2	411154.GFO_3167	1.894e-56	213.0	COG0739@1|root,COG0739@2|Bacteria,4NECF@976|Bacteroidetes,1HY2X@117743|Flavobacteriia	976|Bacteroidetes	M	peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_5500492_4	1303518.CCALI_02063	3.901e-25	107.0	COG0294@1|root,COG0294@2|Bacteria	2|Bacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK,Pterin_bind
TLS2_k127_5500492_2	123214.PERMA_1676	2.575e-65	232.0	COG1624@1|root,COG1624@2|Bacteria,2G3ZW@200783|Aquificae	200783|Aquificae	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
TLS2_k127_5500492_5	525897.Dbac_0256	8.068e-17	89.0	COG4856@1|root,COG4856@2|Bacteria,1REEU@1224|Proteobacteria,42RY2@68525|delta/epsilon subdivisions,2WNZH@28221|Deltaproteobacteria,2MC38@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM YbbR family protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
TLS2_k127_5500492_1	1267534.KB906759_gene1844	3.63e-126	418.0	COG1109@1|root,COG1109@2|Bacteria,3Y36F@57723|Acidobacteria,2JHU9@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_5500492_3	1125863.JAFN01000001_gene3040	2.153e-54	195.0	COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,42SGQ@68525|delta/epsilon subdivisions,2WPTP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	rfaE	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
TLS2_k127_5500492_0	1232410.KI421420_gene3182	4.453e-176	581.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,43SCA@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	TRCF	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS2_k127_5505505_1	926692.AZYG01000051_gene1851	1.188e-34	151.0	COG1668@1|root,COG1668@2|Bacteria,1W74I@1239|Firmicutes,25MB4@186801|Clostridia,3WC5H@53433|Halanaerobiales	186801|Clostridia	CP	ABC-2 family transporter protein	-	-	-	ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.115	-	-	ABC2_membrane_2
TLS2_k127_5505505_0	382464.ABSI01000020_gene339	8.35e-80	273.0	COG4555@1|root,COG4555@2|Bacteria	2|Bacteria	CP	ABC transporter	natA	-	3.6.3.7	ko:K01990,ko:K09697	ko02010,ko02020,map02010,map02020	M00253,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.115	-	iYO844.BSU02750	ABC_tran
TLS2_k127_5505505_2	1142394.PSMK_20110	1.047e-22	109.0	COG1266@1|root,COG1668@1|root,COG1266@2|Bacteria,COG1668@2|Bacteria,2IXUG@203682|Planctomycetes	203682|Planctomycetes	CP	COG1668 ABC-type Na efflux pump, permease component	-	-	-	ko:K01992,ko:K09696	ko02010,ko02020,map02010,map02020	M00253,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.115	-	-	ABC2_membrane_2,Abi
TLS2_k127_550645_3	1047013.AQSP01000077_gene2270	3.371e-40	156.0	COG1484@1|root,COG1484@2|Bacteria,2NQ23@2323|unclassified Bacteria	2|Bacteria	L	IstB-like ATP binding protein	dnaC	-	3.4.21.53	ko:K02315,ko:K04076	-	-	-	-	ko00000,ko01000,ko01002,ko03032	-	-	-	AAA,IstB_IS21,Lon_C
TLS2_k127_550645_2	1121104.AQXH01000002_gene784	4.641e-52	189.0	COG2096@1|root,COG2096@2|Bacteria,4NFHQ@976|Bacteroidetes,1IRY6@117747|Sphingobacteriia	976|Bacteroidetes	S	Cobalamin adenosyltransferase	yvqK	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
TLS2_k127_550645_0	497964.CfE428DRAFT_2423	1.343e-71	251.0	COG3253@1|root,COG3253@2|Bacteria,46SQD@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Chlorite dismutase	ywfI	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
TLS2_k127_550645_1	926569.ANT_11110	1.24e-57	202.0	COG1082@1|root,COG1082@2|Bacteria,2G5V7@200795|Chloroflexi	200795|Chloroflexi	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS2_k127_5521010_1	1267535.KB906767_gene3226	5.951e-25	112.0	COG1595@1|root,COG1595@2|Bacteria,3Y3BS@57723|Acidobacteria,2JIDF@204432|Acidobacteriia	204432|Acidobacteriia	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_5521010_3	1089455.MOPEL_060_00280	4.884e-08	64.0	COG1216@1|root,COG1216@2|Bacteria,2GKTW@201174|Actinobacteria,4F7PU@85018|Dermatophilaceae	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
TLS2_k127_5521010_2	340177.Cag_1867	7.454e-22	107.0	COG1216@1|root,COG1216@2|Bacteria,1FEN2@1090|Chlorobi	1090|Chlorobi	M	PFAM glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS2_k127_5521010_0	658088.HMPREF0987_01566	2.834e-37	150.0	COG1216@1|root,COG1216@2|Bacteria,1TSTE@1239|Firmicutes,249WH@186801|Clostridia,27J9X@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Glycosyltransferase like family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
TLS2_k127_5521436_1	338966.Ppro_3117	1.177e-76	269.0	COG0318@1|root,COG0318@2|Bacteria,1R5I6@1224|Proteobacteria,42MKC@68525|delta/epsilon subdivisions,2WK3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.1.3.1	ko:K22319	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding
TLS2_k127_5521436_0	1565129.JSFF01000004_gene3061	3.93e-98	329.0	COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,1RZNC@1236|Gammaproteobacteria,2Q9Z7@267890|Shewanellaceae	1236|Gammaproteobacteria	S	PFAM alpha beta hydrolase fold	dhaA	-	3.8.1.5	ko:K01563,ko:K22318	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_5521436_2	509635.N824_11700	1.758e-17	88.0	COG4251@1|root,COG4251@2|Bacteria,4NGXA@976|Bacteroidetes,1IT3D@117747|Sphingobacteriia	976|Bacteroidetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS_3,PAS_9
TLS2_k127_554793_0	1123278.KB893400_gene4065	2.448e-83	284.0	COG1082@1|root,COG1082@2|Bacteria,4NKFY@976|Bacteroidetes,47N9K@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_554793_1	1267535.KB906767_gene1344	8.492e-65	249.0	COG0265@1|root,COG2203@1|root,COG2208@1|root,COG0265@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4A2@57723|Acidobacteria,2JJ6J@204432|Acidobacteriia	204432|Acidobacteriia	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_3,SpoIIE
TLS2_k127_5551699_0	596151.DesfrDRAFT_0295	1.687e-86	297.0	COG2267@1|root,COG2267@2|Bacteria,1QW7I@1224|Proteobacteria,42R6T@68525|delta/epsilon subdivisions,2WMU7@28221|Deltaproteobacteria,2MEJZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	TAP-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_5551699_1	767817.Desgi_1017	7.526e-57	204.0	COG1309@1|root,COG1309@2|Bacteria,1V63U@1239|Firmicutes,24REM@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_5551699_2	331678.Cphamn1_0232	5.007e-46	171.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	vapC	GO:0001666,GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0036293,GO:0040008,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0070482,GO:0071704,GO:0075136,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_5551699_6	331678.Cphamn1_0231	3.57e-17	82.0	COG5450@1|root,COG5450@2|Bacteria	2|Bacteria	K	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
TLS2_k127_5551699_8	1267535.KB906767_gene420	5.384e-05	48.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_5551699_3	410358.Mlab_1184	8.693e-42	168.0	COG1266@1|root,arCOG02768@2157|Archaea,2XZ3X@28890|Euryarchaeota,2NAUF@224756|Methanomicrobia	224756|Methanomicrobia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_5551699_4	1267535.KB906767_gene4385	6.594e-33	131.0	2CK96@1|root,3346F@2|Bacteria,3Y5N2@57723|Acidobacteria,2JJZD@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5551699_7	640511.BC1002_1606	3.595e-10	63.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2WA2T@28216|Betaproteobacteria,1KAHM@119060|Burkholderiaceae	28216|Betaproteobacteria	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
TLS2_k127_5551699_5	926549.KI421517_gene3299	4.962e-25	122.0	COG1874@1|root,COG1874@2|Bacteria,4NQBQ@976|Bacteroidetes,47QIS@768503|Cytophagia	976|Bacteroidetes	G	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
TLS2_k127_555628_0	862908.BMS_1335	5.531e-25	114.0	COG0847@1|root,COG0847@2|Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
TLS2_k127_5560326_0	1267535.KB906767_gene4114	3.049e-166	531.0	COG2159@1|root,COG2159@2|Bacteria,3Y2HY@57723|Acidobacteria,2JI2D@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_5560326_2	251229.Chro_1072	4.739e-29	120.0	2BG65@1|root,32A2Y@2|Bacteria,1G6VZ@1117|Cyanobacteria,3VJZ3@52604|Pleurocapsales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5560326_1	1267535.KB906767_gene5008	1.61e-134	448.0	COG4447@1|root,COG4447@2|Bacteria,3Y2MX@57723|Acidobacteria,2JMA6@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5574590_0	234267.Acid_7026	1.191e-131	449.0	COG1629@1|root,COG3485@1|root,COG3485@2|Bacteria,COG4771@2|Bacteria,3Y7F9@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5574590_3	1173028.ANKO01000030_gene3280	1.405e-87	308.0	COG2244@1|root,COG2244@2|Bacteria,1GCMK@1117|Cyanobacteria	1117|Cyanobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
TLS2_k127_5574590_1	1499967.BAYZ01000045_gene2666	8.156e-110	373.0	COG0077@1|root,COG0077@2|Bacteria,2NR2C@2323|unclassified Bacteria	2|Bacteria	E	Prephenate dehydratase	pheA	GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	2.5.1.54,4.2.1.51,5.4.99.5	ko:K03856,ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022,M00024,M00025	R00691,R01373,R01715,R01826	RC00360,RC00435,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_2667	CM_2,PDT
TLS2_k127_5574590_2	518766.Rmar_0331	1.579e-94	324.0	COG2355@1|root,COG2355@2|Bacteria,4NEBG@976|Bacteroidetes,1FJUG@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
TLS2_k127_5574590_4	485913.Krac_11786	1.043e-61	228.0	COG0249@1|root,COG0249@2|Bacteria,2G8CJ@200795|Chloroflexi	200795|Chloroflexi	L	PFAM DNA mismatch repair protein MutS domain protein	-	-	-	-	-	-	-	-	-	-	-	-	MutS_V
TLS2_k127_5575763_1	530564.Psta_0312	9.418e-166	532.0	COG1505@1|root,COG1505@2|Bacteria,2IXRJ@203682|Planctomycetes	203682|Planctomycetes	E	Prolyl oligopeptidase	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_5575763_0	1403819.BATR01000191_gene6501	5.314e-227	717.0	COG3119@1|root,COG3119@2|Bacteria,46S9C@74201|Verrucomicrobia,2ITNC@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
TLS2_k127_5578918_2	204669.Acid345_1420	6.547e-40	153.0	COG0750@1|root,COG0750@2|Bacteria,3Y2KN@57723|Acidobacteria,2JI1B@204432|Acidobacteriia	204432|Acidobacteriia	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
TLS2_k127_5578918_0	1123371.ATXH01000001_gene1316	8.793e-122	406.0	COG0743@1|root,COG0743@2|Bacteria,2GHA5@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
TLS2_k127_5578918_3	663321.REG_1291	1.607e-33	140.0	COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,1T63B@1236|Gammaproteobacteria,282PQ@191675|unclassified Enterobacteriaceae	1236|Gammaproteobacteria	M	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TLS2_k127_5578918_1	1267535.KB906767_gene2288	3.206e-54	195.0	COG0020@1|root,COG0020@2|Bacteria,3Y485@57723|Acidobacteria,2JI0B@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS2_k127_5585890_0	1232410.KI421421_gene3885	1.112e-314	977.0	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,43CSP@68525|delta/epsilon subdivisions,2X80C@28221|Deltaproteobacteria,43UBZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	EXOIII	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
TLS2_k127_5585890_1	1232410.KI421421_gene3886	2.123e-62	216.0	COG0745@1|root,COG0745@2|Bacteria,1RHCU@1224|Proteobacteria,42T0G@68525|delta/epsilon subdivisions,2WPJM@28221|Deltaproteobacteria,43V0H@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_5587745_0	1111069.TCCBUS3UF1_4090	1.413e-178	570.0	COG0427@1|root,COG0427@2|Bacteria,1WJIT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Acetyl-CoA hydrolase/transferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
TLS2_k127_5587745_1	945713.IALB_2183	1.122e-85	297.0	COG0686@1|root,COG0686@2|Bacteria	2|Bacteria	E	alanine dehydrogenase activity	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TLS2_k127_5587745_2	316067.Geob_3081	2.12e-60	218.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria,43TK2@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
TLS2_k127_5591285_0	204669.Acid345_4603	6.945e-65	245.0	COG0457@1|root,COG0457@2|Bacteria,3Y35N@57723|Acidobacteria,2JHIM@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
TLS2_k127_5591285_1	1158150.KB906241_gene1122	9.272e-39	150.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1WX6F@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_5609982_0	1150398.JIBJ01000003_gene1628	3.654e-55	198.0	COG4319@1|root,COG4319@2|Bacteria,2IHRK@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_3
TLS2_k127_5609982_1	381666.H16_B1457	1.856e-46	177.0	COG0346@1|root,COG0346@2|Bacteria,1RABQ@1224|Proteobacteria,2VS4J@28216|Betaproteobacteria,1K82W@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_5609982_2	1032480.MLP_18560	1.742e-15	80.0	COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria,4DRQK@85009|Propionibacteriales	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
TLS2_k127_5620369_0	1267535.KB906767_gene4699	4.028e-133	446.0	COG4447@1|root,COG4447@2|Bacteria,3Y2MX@57723|Acidobacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
TLS2_k127_5620369_3	1123277.KB893173_gene1725	5.78e-49	194.0	COG0793@1|root,COG0793@2|Bacteria,4NFEN@976|Bacteroidetes,47PTG@768503|Cytophagia	976|Bacteroidetes	M	PFAM Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41,Tricorn_C1
TLS2_k127_5620369_2	234267.Acid_6615	1.778e-54	203.0	28KX8@1|root,2ZAD8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5620369_4	1122917.KB899682_gene3824	1.071e-09	61.0	COG3653@1|root,COG3653@2|Bacteria,1TSGD@1239|Firmicutes,4HBQ4@91061|Bacilli,26VUM@186822|Paenibacillaceae	91061|Bacilli	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
TLS2_k127_5620369_1	1232410.KI421424_gene1840	4.497e-84	284.0	COG0500@1|root,COG2226@2|Bacteria,1R5UA@1224|Proteobacteria,42P7B@68525|delta/epsilon subdivisions,2WJSN@28221|Deltaproteobacteria,43SXN@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_32
TLS2_k127_5635182_0	1123322.KB904656_gene685	3.475e-99	348.0	2DBT1@1|root,2ZAV2@2|Bacteria,2H4J7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5636645_2	1267533.KB906740_gene322	1.374e-81	285.0	COG0673@1|root,COG0673@2|Bacteria,3Y4KS@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_5636645_0	234267.Acid_5431	6.754e-235	771.0	COG1629@1|root,COG4771@2|Bacteria,3Y2GB@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_5636645_1	1501230.ET33_15510	1.14e-102	344.0	COG1162@1|root,COG1162@2|Bacteria,1TP8Q@1239|Firmicutes,4H9PJ@91061|Bacilli,26R2G@186822|Paenibacillaceae	91061|Bacilli	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA_2	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
TLS2_k127_5636645_3	221288.JH992901_gene5375	1.803e-15	89.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gumK	-	2.4.1.264	ko:K13659	-	-	R09732	RC00005,RC00049	ko00000,ko01000,ko01003	-	GT70	-	Glyco_trans_1_4,Glycos_transf_1,Glycos_transf_2
TLS2_k127_5646927_0	316067.Geob_2097	3.552e-122	401.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,43UEF@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TLS2_k127_5646927_1	338966.Ppro_3016	3.541e-91	302.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42QNS@68525|delta/epsilon subdivisions,2WMSN@28221|Deltaproteobacteria,43SYM@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
TLS2_k127_5648307_0	525904.Tter_0222	1.996e-139	453.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2NPE1@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M50	rip3	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K06212,ko:K06402	-	-	-	-	ko00000,ko01000,ko01002,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	CBS,Form_Nir_trans,Peptidase_M50
TLS2_k127_5648307_1	926556.Echvi_1482	8.155e-09	67.0	COG4775@1|root,COG4775@2|Bacteria,4NICB@976|Bacteroidetes,47PNV@768503|Cytophagia	976|Bacteroidetes	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
TLS2_k127_5650684_0	204669.Acid345_4634	1.352e-132	439.0	COG1199@1|root,COG1199@2|Bacteria,3Y3DN@57723|Acidobacteria,2JHJZ@204432|Acidobacteriia	204432|Acidobacteriia	L	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
TLS2_k127_5650684_1	1340493.JNIF01000003_gene3076	4.804e-39	159.0	COG0457@1|root,COG0457@2|Bacteria,3Y3BD@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TPR_11,TPR_16,TPR_2,TPR_8
TLS2_k127_5650684_2	641524.ADICYQ_5444	0.0002986	49.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS2_k127_5663979_2	272123.Anacy_4912	6.462e-10	68.0	COG0438@1|root,COG0438@2|Bacteria,1GCW5@1117|Cyanobacteria	1117|Cyanobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
TLS2_k127_5663979_3	1297617.JPJD01000004_gene2781	8.863e-06	59.0	COG3307@1|root,COG3307@2|Bacteria,1TQGY@1239|Firmicutes,24AB7@186801|Clostridia,268HE@186813|unclassified Clostridiales	186801|Clostridia	M	O-Antigen ligase	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	Wzy_C
TLS2_k127_5663979_1	671143.DAMO_0251	2.199e-47	179.0	COG1682@1|root,COG1682@2|Bacteria,2NQ2H@2323|unclassified Bacteria	2|Bacteria	U	ABC-2 type transporter	wzm	-	-	ko:K01992,ko:K09690,ko:K09691,ko:K09692	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC2_membrane
TLS2_k127_5663979_0	1283300.ATXB01000001_gene2336	2.684e-92	315.0	COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,1RN2T@1236|Gammaproteobacteria,1XF3R@135618|Methylococcales	135618|Methylococcales	GM	Wzt C-terminal domain	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
TLS2_k127_5666315_0	1340493.JNIF01000003_gene4593	4.65e-112	380.0	COG2199@1|root,COG2203@1|root,COG3437@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,3Y9F7@57723|Acidobacteria	57723|Acidobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
TLS2_k127_5666315_1	1499967.BAYZ01000093_gene4029	2.325e-77	267.0	COG1216@1|root,COG1216@2|Bacteria,2NP6P@2323|unclassified Bacteria	2|Bacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_5667299_1	176946.XP_007424811.1	2.502e-09	64.0	KOG2649@1|root,KOG2649@2759|Eukaryota,38DE0@33154|Opisthokonta,3B9RU@33208|Metazoa,3CSI8@33213|Bilateria,4899Q@7711|Chordata,49576@7742|Vertebrata	33208|Metazoa	S	insulin processing	CPN1	GO:0002673,GO:0002682,GO:0002697,GO:0002920,GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0004185,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008236,GO:0008237,GO:0008238,GO:0009056,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0010467,GO:0010468,GO:0010815,GO:0010817,GO:0012505,GO:0014070,GO:0016020,GO:0016485,GO:0016486,GO:0016787,GO:0017144,GO:0017171,GO:0019222,GO:0019538,GO:0030070,GO:0030141,GO:0030162,GO:0030449,GO:0031347,GO:0031410,GO:0031960,GO:0031982,GO:0032101,GO:0033993,GO:0034641,GO:0036477,GO:0042221,GO:0042445,GO:0042737,GO:0043025,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044297,GO:0044421,GO:0044424,GO:0044425,GO:0044444,GO:0044456,GO:0044459,GO:0044464,GO:0045202,GO:0048545,GO:0048583,GO:0050727,GO:0050776,GO:0050789,GO:0050896,GO:0051171,GO:0051246,GO:0051384,GO:0051604,GO:0060255,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070613,GO:0071704,GO:0071944,GO:0080090,GO:0080134,GO:0097060,GO:0097458,GO:0097708,GO:0098590,GO:0099503,GO:0140096,GO:1901142,GO:1901564,GO:1901565,GO:1901575,GO:1903317,GO:2000257	3.4.17.22,3.4.17.3	ko:K01292,ko:K07752,ko:K13022	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CarboxypepD_reg,Peptidase_M14
TLS2_k127_5667299_0	1267535.KB906767_gene4711	4.46e-319	1013.0	COG4932@1|root,COG4932@2|Bacteria,3Y6EM@57723|Acidobacteria,2JKUS@204432|Acidobacteriia	204432|Acidobacteriia	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_5669005_10	246197.MXAN_4636	7.406e-12	69.0	COG1664@1|root,COG1664@2|Bacteria,1RHS7@1224|Proteobacteria,433TD@68525|delta/epsilon subdivisions,2X9WK@28221|Deltaproteobacteria,2YVM0@29|Myxococcales	28221|Deltaproteobacteria	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS2_k127_5669005_0	234267.Acid_2148	1.637e-165	533.0	COG0612@1|root,COG0612@2|Bacteria,3Y77X@57723|Acidobacteria	57723|Acidobacteria	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_5669005_3	234267.Acid_2149	3.436e-110	372.0	COG0612@1|root,COG0612@2|Bacteria,3Y79G@57723|Acidobacteria	57723|Acidobacteria	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_5669005_1	518766.Rmar_0538	5.752e-137	442.0	COG2041@1|root,COG2041@2|Bacteria,4NK0M@976|Bacteroidetes	976|Bacteroidetes	S	Oxidoreductase molybdopterin binding domain	-	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
TLS2_k127_5669005_7	768671.ThimaDRAFT_1696	1.381e-61	218.0	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,1RS9K@1236|Gammaproteobacteria,1WYDE@135613|Chromatiales	135613|Chromatiales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
TLS2_k127_5669005_6	1232410.KI421417_gene2753	4.213e-63	230.0	COG1877@1|root,COG1877@2|Bacteria,1PF7W@1224|Proteobacteria,42QT9@68525|delta/epsilon subdivisions,2WNR9@28221|Deltaproteobacteria,43UM2@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
TLS2_k127_5669005_8	234267.Acid_4815	2.167e-29	122.0	COG3682@1|root,COG3682@2|Bacteria,3Y8BB@57723|Acidobacteria	57723|Acidobacteria	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
TLS2_k127_5669005_9	879212.DespoDRAFT_03504	7.338e-23	113.0	COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,42RUN@68525|delta/epsilon subdivisions,2WMXF@28221|Deltaproteobacteria,2MJMS@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HATPase_c,HisKA_3
TLS2_k127_5669005_5	335543.Sfum_2837	2.936e-66	246.0	COG4191@1|root,COG4251@1|root,COG4191@2|Bacteria,COG4251@2|Bacteria,1RCM9@1224|Proteobacteria,42QA2@68525|delta/epsilon subdivisions,2X7QC@28221|Deltaproteobacteria,2MQRX@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE3,PAS_9
TLS2_k127_5669005_4	335543.Sfum_1863	3.065e-101	335.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2WK5J@28221|Deltaproteobacteria,2MQ5V@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TLS2_k127_5669005_2	1101195.Meth11DRAFT_2557	2.106e-134	433.0	COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,2VIXE@28216|Betaproteobacteria,2KM5N@206350|Nitrosomonadales	206350|Nitrosomonadales	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,Formyl_trans_N
TLS2_k127_5669098_0	452637.Oter_1368	3.326e-88	320.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_5669098_1	1265505.ATUG01000001_gene4139	8.227e-07	55.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,42Q8R@68525|delta/epsilon subdivisions,2WMDK@28221|Deltaproteobacteria,2MJEG@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
TLS2_k127_5677294_1	1128421.JAGA01000002_gene1496	2.34e-153	495.0	COG3875@1|root,COG3875@2|Bacteria	2|Bacteria	S	lactate racemase activity	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
TLS2_k127_5677294_3	1168059.KB899087_gene1387	1.177e-65	233.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TTVF@28211|Alphaproteobacteria,3EZC2@335928|Xanthobacteraceae	28211|Alphaproteobacteria	IQ	KR domain	MA20_35845	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
TLS2_k127_5677294_2	443143.GM18_1345	3.844e-77	269.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2WMQ4@28221|Deltaproteobacteria,43SF7@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Inositol monophosphatase family	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS2_k127_5677294_0	1121335.Clst_2416	7.519e-247	769.0	COG0362@1|root,COG0362@2|Bacteria,1TP4I@1239|Firmicutes,248YA@186801|Clostridia	186801|Clostridia	H	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
TLS2_k127_5684894_1	401053.AciPR4_3485	1.507e-09	63.0	COG0250@1|root,COG0250@2|Bacteria,3Y3I1@57723|Acidobacteria,2JHYX@204432|Acidobacteriia	204432|Acidobacteriia	K	Participates in transcription elongation, termination and antitermination	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5684894_0	1340493.JNIF01000003_gene3519	1.094e-152	501.0	COG1629@1|root,COG4771@2|Bacteria,3Y3HA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_5687088_1	1267535.KB906767_gene1493	1.208e-14	80.0	COG1595@1|root,COG1595@2|Bacteria,3Y7WY@57723|Acidobacteria,2JN22@204432|Acidobacteriia	204432|Acidobacteriia	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_5687088_2	1122179.KB890423_gene2314	6.151e-12	79.0	COG0793@1|root,COG0793@2|Bacteria,4NEFX@976|Bacteroidetes,1IY6Q@117747|Sphingobacteriia	976|Bacteroidetes	M	Peptidase family S41	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S41,Tricorn_C1
TLS2_k127_5687088_0	1161902.HMPREF0378_0819	1.499e-20	107.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,3WCHD@538999|Clostridiales incertae sedis	186801|Clostridia	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
TLS2_k127_5696167_4	240015.ACP_1890	6.155e-12	70.0	2DMGW@1|root,32REM@2|Bacteria,3Y4XX@57723|Acidobacteria,2JJER@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-B_box
TLS2_k127_5696167_5	1267535.KB906767_gene1042	4.794e-05	53.0	COG5662@1|root,COG5662@2|Bacteria,3Y4S0@57723|Acidobacteria	57723|Acidobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_5696167_2	1267535.KB906767_gene1043	1.72e-44	169.0	COG1595@1|root,COG1595@2|Bacteria,3Y4HK@57723|Acidobacteria,2JJAJ@204432|Acidobacteriia	204432|Acidobacteriia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_5696167_1	204669.Acid345_4041	3.072e-52	188.0	COG1327@1|root,COG1327@2|Bacteria,3Y4GA@57723|Acidobacteria,2JJC7@204432|Acidobacteriia	204432|Acidobacteriia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
TLS2_k127_5696167_0	316067.Geob_0904	1.138e-262	832.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,43T3K@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-3	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS2_k127_5696167_3	479434.Sthe_0905	2.762e-14	75.0	COG0611@1|root,COG0611@2|Bacteria,2G6SH@200795|Chloroflexi,27XMF@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_5712126_2	234267.Acid_1240	4.227e-26	114.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Dioxygenase_C,Plug,TonB_dep_Rec
TLS2_k127_5712126_4	1047013.AQSP01000112_gene371	3.837e-06	53.0	COG2091@1|root,COG2091@2|Bacteria,2NQ9X@2323|unclassified Bacteria	2|Bacteria	H	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
TLS2_k127_5712126_0	700598.Niako_4842	1.089e-91	312.0	COG1388@1|root,COG1388@2|Bacteria,4NISJ@976|Bacteroidetes	976|Bacteroidetes	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
TLS2_k127_5712126_1	338969.Rfer_3144	1.521e-63	224.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_5712126_3	338969.Rfer_3145	7.023e-19	90.0	COG0599@1|root,COG0599@2|Bacteria,1P85X@1224|Proteobacteria,2W5YK@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
TLS2_k127_5735716_1	330214.NIDE0812	1.723e-93	308.0	COG0413@1|root,COG0413@2|Bacteria,3J0GX@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TLS2_k127_5735716_3	330214.NIDE0813	1.731e-42	161.0	COG1547@1|root,COG1547@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF309)	-	-	-	ko:K09763	-	-	-	-	ko00000	-	-	-	DUF309
TLS2_k127_5735716_0	330214.NIDE0814	1.167e-95	321.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	apaH	GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	iECIAI39_1322.ECIAI39_0052,iEcSMS35_1347.EcSMS35_0053,iJN746.PP_0399,iSDY_1059.SDY_0074	Metallophos
TLS2_k127_5735716_2	330214.NIDE0820	3.523e-64	223.0	COG0780@1|root,COG0780@2|Bacteria,3J0R4@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
TLS2_k127_575729_1	1515613.HQ37_03465	8.128e-91	307.0	COG0796@1|root,COG0796@2|Bacteria,4NG1C@976|Bacteroidetes,2FKYW@200643|Bacteroidia,22WDQ@171551|Porphyromonadaceae	976|Bacteroidetes	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
TLS2_k127_575729_0	1267535.KB906767_gene1344	2.096e-105	376.0	COG0265@1|root,COG2203@1|root,COG2208@1|root,COG0265@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4A2@57723|Acidobacteria,2JJ6J@204432|Acidobacteriia	204432|Acidobacteriia	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_3,SpoIIE
TLS2_k127_575729_2	396588.Tgr7_1731	2.091e-08	59.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1SYV1@1236|Gammaproteobacteria,1X2IS@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
TLS2_k127_5775063_2	1267535.KB906767_gene2307	2.489e-31	129.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	asmA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475	-	ko:K07289,ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA,AsmA_2
TLS2_k127_5775063_0	452637.Oter_3657	1.91e-72	259.0	COG2207@1|root,COG2207@2|Bacteria,46YE0@74201|Verrucomicrobia,3K9DW@414999|Opitutae	414999|Opitutae	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS2_k127_5775063_1	439235.Dalk_4371	3.344e-51	189.0	COG3640@1|root,COG3640@2|Bacteria,1RB02@1224|Proteobacteria,42NBP@68525|delta/epsilon subdivisions,2WKS7@28221|Deltaproteobacteria,2MJA2@213118|Desulfobacterales	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
TLS2_k127_5780289_0	234267.Acid_5526	1.135e-151	493.0	COG1032@1|root,COG1032@2|Bacteria,3Y2NI@57723|Acidobacteria	57723|Acidobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
TLS2_k127_5780289_1	504472.Slin_5006	6.281e-123	407.0	COG1554@1|root,COG1554@2|Bacteria,4NEWW@976|Bacteroidetes,47JFT@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolase family 65, N-terminal domain	-	-	3.2.1.51	ko:K15923	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	GH95	-	Glyco_hyd_65N_2
TLS2_k127_578859_4	1237149.C900_00061	2.714e-08	59.0	COG0308@1|root,COG0308@2|Bacteria,4NGTZ@976|Bacteroidetes,47MWS@768503|Cytophagia	976|Bacteroidetes	E	Peptidase family M1 domain	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
TLS2_k127_578859_1	344747.PM8797T_25411	1.495e-137	443.0	COG3622@1|root,COG3622@2|Bacteria,2IYNY@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_578859_2	1519464.HY22_13270	8.529e-71	250.0	COG4222@1|root,COG4222@2|Bacteria	2|Bacteria	S	Esterase-like activity of phytase	MA20_03555	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,Phytase-like
TLS2_k127_578859_0	404589.Anae109_0036	1.238e-245	768.0	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,42N9T@68525|delta/epsilon subdivisions,2WIMI@28221|Deltaproteobacteria,2Z24K@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
TLS2_k127_578859_3	1267534.KB906756_gene681	4.715e-41	158.0	COG2208@1|root,COG3437@1|root,COG2208@2|Bacteria,COG3437@2|Bacteria,3Y56X@57723|Acidobacteria,2JM0P@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,SpoIIE
TLS2_k127_5789094_0	880073.Calab_1142	7.506e-179	567.0	COG1350@1|root,COG1350@2|Bacteria,2NNY3@2323|unclassified Bacteria	2|Bacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_5789094_1	1380391.JIAS01000013_gene3723	2.695e-47	175.0	COG3542@1|root,COG3542@2|Bacteria,1RHBE@1224|Proteobacteria,2U962@28211|Alphaproteobacteria,2JSSJ@204441|Rhodospirillales	204441|Rhodospirillales	S	Cupin superfamily (DUF985)	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
TLS2_k127_5789094_2	1306174.JODP01000001_gene4956	1.303e-15	87.0	COG1188@1|root,COG1188@2|Bacteria,2IQ6F@201174|Actinobacteria	201174|Actinobacteria	J	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit S4 paralog	hslR	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
TLS2_k127_579739_3	1278073.MYSTI_06523	8.856e-30	124.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2YUVF@29|Myxococcales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TLS2_k127_579739_2	234267.Acid_1992	9.13e-54	207.0	COG1680@1|root,COG1680@2|Bacteria,3Y8A8@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_579739_0	234267.Acid_7648	3.541e-267	844.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	GHL6
TLS2_k127_579739_1	1121405.dsmv_0019	1.075e-180	574.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria,2MI6F@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM aminotransferase class I and II	yfdZ	-	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_5805090_1	667632.KB890164_gene1639	5.651e-45	166.0	COG0391@1|root,COG0391@2|Bacteria,1NK78@1224|Proteobacteria,2VMUY@28216|Betaproteobacteria,1K5SP@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Uncharacterised protein family UPF0052	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
TLS2_k127_5805090_4	579137.Metvu_0906	8.696e-31	130.0	COG2085@1|root,arCOG00457@2157|Archaea,2XUD2@28890|Euryarchaeota,23QAN@183939|Methanococci	183939|Methanococci	C	PFAM NADP oxidoreductase coenzyme F420-dependent	-	GO:0000041,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006826,GO:0008150,GO:0008152,GO:0008823,GO:0015677,GO:0015682,GO:0016020,GO:0016021,GO:0016491,GO:0016722,GO:0016723,GO:0030001,GO:0031224,GO:0031226,GO:0033216,GO:0034220,GO:0034755,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0052851,GO:0055085,GO:0055114,GO:0071944,GO:0072512,GO:0097286,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098706,GO:0098711,GO:0098739,GO:0099587	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
TLS2_k127_5805090_5	1408424.JHYI01000040_gene2372	3.84e-19	102.0	28HMX@1|root,2Z7WB@2|Bacteria,1TPJG@1239|Firmicutes,4HBRI@91061|Bacilli,1ZCDH@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5805090_0	1089547.KB913013_gene2904	3.934e-68	240.0	COG1131@1|root,COG1131@2|Bacteria,4NJ0D@976|Bacteroidetes,47K40@768503|Cytophagia	976|Bacteroidetes	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_5805090_8	1499967.BAYZ01000041_gene2397	3.894e-05	55.0	COG0457@1|root,COG0457@2|Bacteria,2NRIR@2323|unclassified Bacteria	2|Bacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_2,TPR_8
TLS2_k127_5805090_6	497964.CfE428DRAFT_1080	1.111e-18	98.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,46UMD@74201|Verrucomicrobia	2|Bacteria	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_10,TPR_11,TPR_16,TPR_2,TPR_8
TLS2_k127_5805090_3	768671.ThimaDRAFT_2447	2.415e-38	156.0	COG0715@1|root,COG0715@2|Bacteria,1REGQ@1224|Proteobacteria,1S58R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport systems periplasmic	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TLS2_k127_5805090_2	1304883.KI912532_gene2867	1.772e-40	168.0	COG4585@1|root,COG4585@2|Bacteria,1RGET@1224|Proteobacteria,2VPRS@28216|Betaproteobacteria,2KZ4H@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_5805090_7	234267.Acid_2206	1.592e-17	88.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y358@57723|Acidobacteria	57723|Acidobacteria	T	SMART protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,SpoIIE
TLS2_k127_5807684_1	1434325.AZQN01000008_gene2918	6.825e-85	289.0	COG1409@1|root,COG1409@2|Bacteria,4NN8T@976|Bacteroidetes,47PD0@768503|Cytophagia	976|Bacteroidetes	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS2_k127_5807684_0	471852.Tcur_2962	7.687e-154	499.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4EI99@85012|Streptosporangiales	201174|Actinobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_580846_0	204669.Acid345_3357	1.145e-122	421.0	COG4191@1|root,COG4191@2|Bacteria,3Y3X4@57723|Acidobacteria,2JING@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,HisKA_7TM,PAS,PAS_4
TLS2_k127_580846_1	234267.Acid_1510	9.576e-06	56.0	COG3485@1|root,COG3485@2|Bacteria,3Y44E@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_5810021_1	589865.DaAHT2_1309	4.278e-23	115.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,2MIBK@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TLS2_k127_5810021_0	204669.Acid345_2474	3.227e-67	248.0	COG2911@1|root,COG2911@2|Bacteria,3Y3A6@57723|Acidobacteria,2JHS8@204432|Acidobacteriia	204432|Acidobacteriia	M	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
TLS2_k127_5820318_1	290397.Adeh_2142	3.493e-71	244.0	COG0252@1|root,COG0252@2|Bacteria,1RHAW@1224|Proteobacteria,42SNH@68525|delta/epsilon subdivisions,2WPQC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EJ	PFAM Asparaginase	aspG	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
TLS2_k127_5820318_0	716544.wcw_0742	4.142e-73	256.0	COG1090@1|root,COG1090@2|Bacteria,2JFV6@204428|Chlamydiae	204428|Chlamydiae	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
TLS2_k127_5820318_2	234267.Acid_4046	2.609e-58	214.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_4046|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5820318_3	1121439.dsat_1696	7.872e-19	89.0	COG0500@1|root,COG0500@2|Bacteria,1QW86@1224|Proteobacteria,42N1Q@68525|delta/epsilon subdivisions,2WJJS@28221|Deltaproteobacteria,2MA1B@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	O-methyltransferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
TLS2_k127_5833328_0	13035.Dacsa_1337	1.989e-147	474.0	COG2421@1|root,COG2421@2|Bacteria,1G2PU@1117|Cyanobacteria	1117|Cyanobacteria	C	PFAM Acetamidase Formamidase family	-	-	3.5.1.49	ko:K01455	ko00460,ko00630,ko00910,ko01200,map00460,map00630,map00910,map01200	-	R00524	RC02432,RC02810	ko00000,ko00001,ko01000	-	-	-	FmdA_AmdA
TLS2_k127_5833328_2	243231.GSU3304	1.272e-10	74.0	28NE8@1|root,2ZBGT@2|Bacteria,1R39S@1224|Proteobacteria,43DJS@68525|delta/epsilon subdivisions,2X8R1@28221|Deltaproteobacteria,43U5K@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5833328_1	1336208.JADY01000012_gene2979	2.013e-21	96.0	COG0747@1|root,COG0747@2|Bacteria,1MWBH@1224|Proteobacteria,2TTF4@28211|Alphaproteobacteria,2JV79@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_5835001_2	1120746.CCNL01000017_gene2842	8.2e-63	220.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
TLS2_k127_5835001_1	1267535.KB906767_gene1717	1.843e-66	239.0	COG0697@1|root,2Z7ID@2|Bacteria,3Y8N8@57723|Acidobacteria,2JNIX@204432|Acidobacteriia	1267535.KB906767_gene1717|-	EG	L-rhamnose-proton symport protein (RhaT)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5835001_0	880070.Cycma_1902	1.539e-190	625.0	28MHM@1|root,2ZAUH@2|Bacteria,4NKMG@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_584341_7	1288494.EBAPG3_18120	9.949e-38	144.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VQWS@28216|Betaproteobacteria,371ZC@32003|Nitrosomonadales	28216|Betaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_584341_0	1237149.C900_01898	2.481e-227	720.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,47MV2@768503|Cytophagia	976|Bacteroidetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_584341_2	935845.JADQ01000050_gene3902	1.375e-133	437.0	COG2942@1|root,COG2942@2|Bacteria,1TQMG@1239|Firmicutes,4HE7U@91061|Bacilli,26T2B@186822|Paenibacillaceae	91061|Bacilli	G	Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man)	rnbP	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
TLS2_k127_584341_1	1191523.MROS_0507	3.221e-190	603.0	COG2152@1|root,COG2152@2|Bacteria	2|Bacteria	G	transferase activity, transferring glycosyl groups	unk1	-	2.4.1.281	ko:K16212	-	-	R09943	RC00049	ko00000,ko01000	-	-	-	Glyco_hydro_130
TLS2_k127_584341_6	1340493.JNIF01000003_gene1293	5.312e-42	172.0	COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4DC@57723|Acidobacteria	57723|Acidobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF_3,SpoIIE
TLS2_k127_584341_3	105422.BBPM01000078_gene66	9.268e-88	315.0	COG2730@1|root,COG3291@1|root,COG3420@1|root,COG2730@2|Bacteria,COG3291@2|Bacteria,COG3420@2|Bacteria,2I41P@201174|Actinobacteria,2NNHT@228398|Streptacidiphilus	201174|Actinobacteria	G	Carbohydrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_4_9
TLS2_k127_584341_8	1713.JOFV01000021_gene1274	3.21e-24	111.0	2F7Q9@1|root,3404M@2|Bacteria,2GRK9@201174|Actinobacteria,4F2V6@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1579)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1579
TLS2_k127_584341_5	448385.sce3974	2.689e-55	201.0	COG3506@1|root,COG3506@2|Bacteria	2|Bacteria	M	Protein of unknown function (DUF1349)	yjl217W	-	-	ko:K09702	-	-	-	-	ko00000	-	-	-	DUF1349
TLS2_k127_584341_4	518766.Rmar_1740	1.366e-80	282.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,1FK20@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_5845295_0	671143.DAMO_0568	4.076e-228	727.0	COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria	2|Bacteria	J	elongation factor G	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_5845295_1	1382359.JIAL01000001_gene1834	1.139e-59	220.0	COG2234@1|root,COG2234@2|Bacteria,3Y406@57723|Acidobacteria,2JIRZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_5845295_2	335543.Sfum_1584	0.0002231	46.0	28I4Y@1|root,2Z88D@2|Bacteria,1R95V@1224|Proteobacteria,42RX3@68525|delta/epsilon subdivisions,2WMGE@28221|Deltaproteobacteria,2MQFS@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5849841_8	76114.ebA2553	2.29e-05	48.0	2CCV8@1|root,2Z7KX@2|Bacteria,1MY2J@1224|Proteobacteria,2VQKP@28216|Betaproteobacteria,2KY0X@206389|Rhodocyclales	206389|Rhodocyclales	S	EcsC protein family	-	-	-	-	-	-	-	-	-	-	-	-	EcsC
TLS2_k127_5849841_1	484770.UFO1_1518	9.982e-120	398.0	COG3424@1|root,COG3424@2|Bacteria,1TPUK@1239|Firmicutes,4H3UR@909932|Negativicutes	909932|Negativicutes	Q	PFAM chalcone and stilbene synthase domain protein	-	-	-	ko:K16167	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
TLS2_k127_5849841_5	1122222.AXWR01000049_gene1614	6.372e-46	173.0	COG1755@1|root,COG1755@2|Bacteria,1WMPA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Isoprenylcysteine carboxyl methyltransferase	-	-	-	ko:K16168	-	-	-	-	ko00000,ko01008	-	-	-	ICMT
TLS2_k127_5849841_7	1267535.KB906767_gene4740	2.416e-26	119.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria,2JI38@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TLS2_k127_5849841_4	405948.SACE_3761	1.444e-49	184.0	COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria,4E709@85010|Pseudonocardiales	201174|Actinobacteria	H	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_5849841_2	234267.Acid_7548	2.411e-91	309.0	COG1453@1|root,COG1453@2|Bacteria,3Y6QH@57723|Acidobacteria	57723|Acidobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_5849841_3	1121403.AUCV01000039_gene4374	3.506e-73	256.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42R4A@68525|delta/epsilon subdivisions,2WM9Z@28221|Deltaproteobacteria,2MJDE@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM Silent information regulator protein Sir2	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
TLS2_k127_5849841_6	498848.TaqDRAFT_5350	3.26e-30	130.0	COG2120@1|root,COG2120@2|Bacteria,1WIWN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	GlcNAc-PI de-N-acetylase	lmbE	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_5849841_0	1267535.KB906767_gene4918	1.545e-188	598.0	COG1233@1|root,COG1233@2|Bacteria,3Y9B4@57723|Acidobacteria	57723|Acidobacteria	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TLS2_k127_5866583_2	396588.Tgr7_0917	5.002e-06	50.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1S7G4@1236|Gammaproteobacteria,1WYM8@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TLS2_k127_5866583_1	479434.Sthe_3221	4.215e-09	63.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_5866583_0	1245471.PCA10_37690	4.675e-18	91.0	COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1SASQ@1236|Gammaproteobacteria,1YCT8@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_5884324_2	234267.Acid_7512	1.71e-34	139.0	COG1538@1|root,COG1538@2|Bacteria,3Y54R@57723|Acidobacteria	57723|Acidobacteria	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS2_k127_5884324_1	404589.Anae109_4263	1.324e-106	360.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2YZUC@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	DUF3347,HlyD_D23
TLS2_k127_5884324_0	335543.Sfum_2246	2.424e-241	760.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2MRHY@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
TLS2_k127_5889268_0	1267535.KB906767_gene232	1.772e-203	640.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4832,DUF4874,Glyco_hydro_42
TLS2_k127_5889268_2	243231.GSU2794	6.666e-55	196.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,42RNC@68525|delta/epsilon subdivisions,2WP7G@28221|Deltaproteobacteria,43V0M@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
TLS2_k127_5889268_1	1340493.JNIF01000003_gene1364	3.765e-110	366.0	COG3137@1|root,COG3137@2|Bacteria,3Y380@57723|Acidobacteria	57723|Acidobacteria	M	Protein of unknown function, DUF481	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
TLS2_k127_5889497_4	338966.Ppro_2783	2.8e-69	235.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42NH3@68525|delta/epsilon subdivisions,2WNT3@28221|Deltaproteobacteria	1224|Proteobacteria	C	Belongs to the complex I 20 kDa subunit family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
TLS2_k127_5889497_3	338966.Ppro_2784	6.675e-75	254.0	COG1143@1|root,COG1143@2|Bacteria,1R9YT@1224|Proteobacteria,42P0W@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	hyfH	-	-	ko:K12143,ko:K15831	-	-	-	-	ko00000	-	-	iAPECO1_1312.APECO1_3805,iECABU_c1320.ECABU_c29910,iECED1_1282.ECED1_3171,iECOK1_1307.ECOK1_3094,iUMN146_1321.UM146_02980,iUTI89_1310.UTI89_C3083,ic_1306.c3280	Fer4,Fer4_7
TLS2_k127_5889497_1	338966.Ppro_2785	3.039e-110	364.0	COG0650@1|root,COG0650@2|Bacteria,1QUK1@1224|Proteobacteria,42PHN@68525|delta/epsilon subdivisions,2WKPJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM respiratory-chain NADH dehydrogenase, subunit 1	-	-	-	ko:K14087	-	-	-	-	ko00000	-	-	-	NADHdh
TLS2_k127_5889497_0	338966.Ppro_2786	1.218e-245	769.0	COG0852@1|root,COG3261@1|root,COG0852@2|Bacteria,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,43DST@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	PFAM NADH-ubiquinone oxidoreductase, chain 49kDa	hycE	GO:0003674,GO:0005488,GO:0016151,GO:0043167,GO:0043169,GO:0046872,GO:0046914	1.6.5.3	ko:K00333,ko:K12142,ko:K15830	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iECED1_1282.ECED1_3172,iEcE24377_1341.EcE24377A_2769,iYL1228.KPN_03058	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
TLS2_k127_5889497_2	338966.Ppro_2787	2.26e-101	340.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,42NFV@68525|delta/epsilon subdivisions,2WJZ0@28221|Deltaproteobacteria,43T2H@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
TLS2_k127_5892569_0	234267.Acid_0024	5.537e-108	374.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_5892569_1	234267.Acid_7677	3.507e-54	197.0	COG1595@1|root,COG1595@2|Bacteria,3Y7UW@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
TLS2_k127_5892569_3	1267534.KB906756_gene349	8.157e-19	98.0	COG3577@1|root,COG3577@2|Bacteria	2|Bacteria	S	aspartic-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
TLS2_k127_5892569_4	1050202.KB913024_gene3300	1.487e-06	57.0	COG5479@1|root,COG5479@2|Bacteria,2I4CS@201174|Actinobacteria,408ND@622450|Actinopolysporales	201174|Actinobacteria	M	LGFP repeat	-	-	-	-	-	-	-	-	-	-	-	-	AbfB,LGFP
TLS2_k127_5892569_2	472759.Nhal_3478	1.465e-31	124.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,1S83W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	addiction module antidote protein, HigA family	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
TLS2_k127_5900136_0	29581.BW37_00870	1.172e-232	732.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1MX41@1224|Proteobacteria,2WBDI@28216|Betaproteobacteria,475K6@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
TLS2_k127_5900136_2	882.DVU_2579	7.315e-18	93.0	COG0457@1|root,COG0457@2|Bacteria,1N0Q1@1224|Proteobacteria,42TBT@68525|delta/epsilon subdivisions,2WQ96@28221|Deltaproteobacteria,2MCPE@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	SMART Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
TLS2_k127_5900136_3	335543.Sfum_0052	3.375e-05	50.0	COG3350@1|root,COG3350@2|Bacteria,1Q2BB@1224|Proteobacteria,437XS@68525|delta/epsilon subdivisions,2X37Q@28221|Deltaproteobacteria,2MSBF@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5900136_1	316067.Geob_3461	1.204e-74	260.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,42MP8@68525|delta/epsilon subdivisions,2WKMR@28221|Deltaproteobacteria,43SZE@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
TLS2_k127_5905994_0	243231.GSU2278	4.98e-123	404.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,42MKD@68525|delta/epsilon subdivisions,2WIZP@28221|Deltaproteobacteria,43U2J@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS2_k127_5905994_3	404380.Gbem_1001	2.599e-73	266.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria,43TVN@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
TLS2_k127_5905994_1	1047013.AQSP01000128_gene429	5.39e-96	321.0	COG0330@1|root,COG0330@2|Bacteria,2NNUC@2323|unclassified Bacteria	2|Bacteria	O	prohibitin homologues	hflC	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_5905994_2	234267.Acid_1498	1.77e-76	267.0	COG1030@1|root,COG1030@2|Bacteria,3Y31N@57723|Acidobacteria	57723|Acidobacteria	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
TLS2_k127_5906629_3	653733.Selin_2503	1.501e-34	136.0	COG1694@1|root,COG1694@2|Bacteria	2|Bacteria	FG	Mazg nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
TLS2_k127_5906629_1	933262.AXAM01000027_gene2085	1.451e-87	304.0	COG2378@1|root,COG2378@2|Bacteria,1RBK8@1224|Proteobacteria,42R5D@68525|delta/epsilon subdivisions,2WN2E@28221|Deltaproteobacteria,2MJRI@213118|Desulfobacterales	28221|Deltaproteobacteria	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
TLS2_k127_5906629_0	349124.Hhal_0421	8.089e-103	353.0	COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,1T3FR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function(DUF2779)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2779
TLS2_k127_5906629_4	368407.Memar_0896	7.638e-21	104.0	COG4912@1|root,arCOG05122@2157|Archaea,2XWYV@28890|Euryarchaeota,2N9IE@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
TLS2_k127_5906629_2	404589.Anae109_4101	2.113e-63	222.0	COG2227@1|root,COG2227@2|Bacteria,1RIMR@1224|Proteobacteria,43CQM@68525|delta/epsilon subdivisions,2X7Y3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5906629_5	237368.SCABRO_03627	1.721e-11	68.0	COG3836@1|root,COG3836@2|Bacteria,2IX9H@203682|Planctomycetes	203682|Planctomycetes	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_5913296_5	264732.Moth_1340	6.414e-76	263.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,42EK5@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TLS2_k127_5913296_4	1123070.KB899268_gene2422	1.928e-79	270.0	COG0512@1|root,COG0512@2|Bacteria,46SN1@74201|Verrucomicrobia,2IU46@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EH	Peptidase C26	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS2_k127_5913296_2	518766.Rmar_1042	1.69e-129	429.0	COG0147@1|root,COG0147@2|Bacteria,4NFQ5@976|Bacteroidetes,1FIRE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS2_k127_5913296_1	1267535.KB906767_gene3177	1.833e-226	706.0	COG1158@1|root,COG1158@2|Bacteria,3Y2V3@57723|Acidobacteria,2JHRC@204432|Acidobacteriia	204432|Acidobacteriia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
TLS2_k127_5913296_0	234267.Acid_2027	5.602e-318	993.0	COG0466@1|root,COG0466@2|Bacteria,3Y3DI@57723|Acidobacteria	57723|Acidobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS2_k127_5913296_3	1121335.Clst_2384	5.044e-126	409.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,3WGYG@541000|Ruminococcaceae	186801|Clostridia	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
TLS2_k127_5915102_1	671143.DAMO_2824	7.287e-80	277.0	COG1600@1|root,COG1600@2|Bacteria,2NNWV@2323|unclassified Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
TLS2_k127_5915102_2	592015.HMPREF1705_01343	7.1e-13	80.0	COG1503@1|root,COG1503@2|Bacteria,3TBB9@508458|Synergistetes	508458|Synergistetes	J	translation release factor activity	-	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	-
TLS2_k127_5915102_0	247490.KSU1_B0097	2.384e-110	364.0	COG0448@1|root,COG0448@2|Bacteria,2IWRQ@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the bacterial plant glucose-1-phosphate adenylyltransferase family	-	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
TLS2_k127_5915939_7	1379698.RBG1_1C00001G1798	3.274e-35	139.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5915939_2	234267.Acid_0388	2.617e-118	390.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
TLS2_k127_5915939_0	234267.Acid_0387	1.746e-140	456.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
TLS2_k127_5915939_5	1321815.HMPREF9193_01317	2.219e-63	229.0	COG0524@1|root,COG0524@2|Bacteria,2JA7F@203691|Spirochaetes	203691|Spirochaetes	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS2_k127_5915939_8	641524.ADICYQ_1349	4.091e-35	144.0	COG3509@1|root,COG3509@2|Bacteria	2|Bacteria	Q	xylan catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
TLS2_k127_5915939_4	204669.Acid345_3908	2.802e-65	234.0	COG1349@1|root,COG1349@2|Bacteria,3Y3E1@57723|Acidobacteria,2JHXF@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator, DeoR	-	-	-	ko:K02081	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
TLS2_k127_5915939_6	1267533.KB906737_gene1888	4.804e-63	231.0	COG2222@1|root,COG2222@2|Bacteria,3Y3W8@57723|Acidobacteria,2JHQD@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM Sugar isomerase (SIS)	-	-	-	ko:K02082	-	-	-	-	ko00000,ko01000	-	-	-	SIS
TLS2_k127_5915939_1	1254432.SCE1572_31930	2.908e-128	451.0	COG0515@1|root,COG3903@1|root,COG0515@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,4389V@68525|delta/epsilon subdivisions,2X3J8@28221|Deltaproteobacteria,2YWAY@29|Myxococcales	28221|Deltaproteobacteria	KLT	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS2_k127_5915939_9	1449063.JMLS01000027_gene57	0.0001766	51.0	COG0666@1|root,COG0666@2|Bacteria,1V657@1239|Firmicutes,4HIDE@91061|Bacilli,26WY6@186822|Paenibacillaceae	91061|Bacilli	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4,Ank_5
TLS2_k127_5922424_3	517418.Ctha_0918	1.785e-81	274.0	COG0573@1|root,COG0573@2|Bacteria,1FE1M@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstC	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS2_k127_5922424_0	517418.Ctha_0919	2.392e-129	419.0	COG0581@1|root,COG0581@2|Bacteria,1FE3G@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS2_k127_5922424_2	517418.Ctha_0920	4.999e-107	354.0	COG1117@1|root,COG1117@2|Bacteria	2|Bacteria	P	ATPase-coupled phosphate ion transmembrane transporter activity	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TLS2_k127_5922424_1	517418.Ctha_0921	6.231e-116	380.0	COG1117@1|root,COG1117@2|Bacteria,1FEHB@1090|Chlorobi	1090|Chlorobi	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TLS2_k127_5922424_4	1120966.AUBU01000005_gene3626	4.533e-08	55.0	295NE@1|root,2ZSZT@2|Bacteria,4NPQK@976|Bacteroidetes	976|Bacteroidetes	S	DoxX	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
TLS2_k127_5926964_10	575540.Isop_3456	3.586e-43	161.0	COG0720@1|root,COG0720@2|Bacteria,2J000@203682|Planctomycetes	203682|Planctomycetes	H	COG0720 6-pyruvoyl-tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
TLS2_k127_5926964_9	671143.DAMO_0882	7.97e-45	173.0	COG1028@1|root,COG1028@2|Bacteria,2NQVU@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
TLS2_k127_5926964_4	635013.TherJR_2349	6.372e-124	408.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,249AM@186801|Clostridia,2607Y@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA2	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
TLS2_k127_5926964_11	234267.Acid_2283	2.698e-29	127.0	COG0526@1|root,COG0526@2|Bacteria,3Y4MM@57723|Acidobacteria	57723|Acidobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_5926964_3	1340493.JNIF01000003_gene1935	2.543e-134	441.0	COG0498@1|root,COG0498@2|Bacteria,3Y3G4@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_5926964_1	204669.Acid345_3256	4.999e-186	593.0	COG1239@1|root,COG1239@2|Bacteria,3Y3FM@57723|Acidobacteria,2JHY2@204432|Acidobacteriia	204432|Acidobacteriia	H	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Sigma54_activat
TLS2_k127_5926964_2	1382359.JIAL01000001_gene2487	4.944e-153	494.0	COG4867@1|root,COG4867@2|Bacteria,3Y2VU@57723|Acidobacteria,2JHSR@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA_2
TLS2_k127_5926964_6	667014.Thein_0900	1.186e-77	271.0	COG0568@1|root,COG0568@2|Bacteria,2GH6K@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_5926964_5	555088.DealDRAFT_2956	2.548e-105	351.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,42JIY@68298|Syntrophomonadaceae	186801|Clostridia	F	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
TLS2_k127_5926964_8	1265505.ATUG01000003_gene66	1.053e-45	181.0	COG0477@1|root,COG2814@2|Bacteria,1QUTR@1224|Proteobacteria,42RH5@68525|delta/epsilon subdivisions,2X73Z@28221|Deltaproteobacteria,2MHZ3@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
TLS2_k127_5926964_7	1191523.MROS_1806	3.228e-67	237.0	COG1028@1|root,COG1028@2|Bacteria	1191523.MROS_1806|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	-
TLS2_k127_5926964_0	926550.CLDAP_36590	8.733e-223	710.0	COG2217@1|root,COG2217@2|Bacteria,2G65K@200795|Chloroflexi	200795|Chloroflexi	P	Heavy-metal-associated domain	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS2_k127_5933615_0	929562.Emtol_0864	1.114e-181	580.0	COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes,47JKY@768503|Cytophagia	976|Bacteroidetes	P	C-terminal region of aryl-sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
TLS2_k127_5933615_1	880070.Cycma_1902	6.285e-51	207.0	28MHM@1|root,2ZAUH@2|Bacteria,4NKMG@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5933615_2	1047013.AQSP01000135_gene1560	4.096e-46	182.0	COG2006@1|root,COG2006@2|Bacteria,2NPBD@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,TAT_signal
TLS2_k127_5937803_4	1282360.ABAC460_10470	6.451e-20	89.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,2KFVB@204458|Caulobacterales	204458|Caulobacterales	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_5937803_2	886293.Sinac_4789	5.866e-63	222.0	COG0386@1|root,COG0386@2|Bacteria,2IZ7Z@203682|Planctomycetes	203682|Planctomycetes	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
TLS2_k127_5937803_1	690850.Desaf_2384	5.019e-65	235.0	COG4914@1|root,COG4914@2|Bacteria,1QX3W@1224|Proteobacteria,43BWC@68525|delta/epsilon subdivisions,2X774@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204,NTP_transf_5
TLS2_k127_5937803_0	690850.Desaf_2383	1.364e-79	272.0	COG2129@1|root,COG2129@2|Bacteria,1MVNK@1224|Proteobacteria,43077@68525|delta/epsilon subdivisions,2WVAJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS2_k127_5937803_3	443143.GM18_1319	1.373e-47	186.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	glycosyltransferase 36 associated	-	-	2.4.1.20	ko:K00702,ko:K13688	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000,ko01003	-	GH94,GT36,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
TLS2_k127_5945903_2	661478.OP10G_0223	7.554e-14	79.0	COG3829@1|root,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HWE_HK,HisKA,PAS,PAS_4,PAS_9
TLS2_k127_5945903_0	269799.Gmet_3218	1.159e-27	118.0	COG0745@1|root,COG0745@2|Bacteria,1RD6H@1224|Proteobacteria,42S64@68525|delta/epsilon subdivisions,2WNPP@28221|Deltaproteobacteria,43UZ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_5945903_1	661478.OP10G_4409	1.185e-17	87.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
TLS2_k127_5950012_0	330214.NIDE0494	2.911e-80	274.0	COG1573@1|root,COG1573@2|Bacteria	2|Bacteria	L	deaminated base DNA N-glycosylase activity	udgB	GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4130,UDG
TLS2_k127_5952348_1	1121904.ARBP01000040_gene530	2.668e-49	189.0	COG3119@1|root,COG3119@2|Bacteria,4NGX1@976|Bacteroidetes,47K2H@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_5952348_0	1267535.KB906767_gene1815	1.711e-55	208.0	COG1262@1|root,COG4409@1|root,COG1262@2|Bacteria,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,FGE-sulfatase
TLS2_k127_5955707_2	96561.Dole_0983	5.85e-05	47.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42S1J@68525|delta/epsilon subdivisions,2WP2S@28221|Deltaproteobacteria,2MJG9@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_5955707_0	330214.NIDE0254	4.659e-115	383.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS2_k127_5955707_1	234267.Acid_0090	5.632e-19	100.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	msrA	-	1.1.98.6,1.8.1.9,1.8.4.11,1.8.4.12	ko:K00384,ko:K12057,ko:K12267,ko:K21636	ko00230,ko00240,ko00450,ko01100,map00230,map00240,map00450,map01100	M00053	R02016,R03596,R09372,R11633,R11634,R11635,R11636	RC00013,RC00613,RC02518,RC02873	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.7.11.1	-	-	AhpC-TSA,PMSR,Pyr_redox_2,SelR,Thioredoxin,Thioredoxin_3,Thioredoxin_7,TraF
TLS2_k127_5961962_2	1499967.BAYZ01000095_gene4126	2.252e-82	276.0	COG2192@1|root,COG2192@2|Bacteria,2NNRR@2323|unclassified Bacteria	2|Bacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TLS2_k127_5961962_0	945713.IALB_2724	3.838e-94	312.0	COG2192@1|root,COG2192@2|Bacteria	2|Bacteria	O	nodulation	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TLS2_k127_5961962_3	118161.KB235922_gene1041	4.49e-15	80.0	2DP8V@1|root,33122@2|Bacteria,1G83J@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5961962_4	1131269.AQVV01000005_gene355	1.284e-12	71.0	2EGPU@1|root,33AFZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5961962_1	589865.DaAHT2_1777	1.589e-85	292.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria,2MMKC@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS2_k127_5961962_5	1267535.KB906767_gene2207	0.0002758	45.0	COG1596@1|root,COG1596@2|Bacteria,3Y57H@57723|Acidobacteria,2JJNS@204432|Acidobacteriia	204432|Acidobacteriia	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
TLS2_k127_597852_7	278963.ATWD01000001_gene3611	3.435e-29	117.0	COG0254@1|root,COG0254@2|Bacteria,3Y5J8@57723|Acidobacteria,2JJQ4@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
TLS2_k127_597852_0	234267.Acid_6670	6.761e-143	461.0	COG0216@1|root,COG0216@2|Bacteria,3Y2N9@57723|Acidobacteria	57723|Acidobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS2_k127_597852_3	240015.ACP_2650	4.12e-55	204.0	COG2890@1|root,COG2890@2|Bacteria,3Y4KU@57723|Acidobacteria,2JJCF@204432|Acidobacteriia	204432|Acidobacteriia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
TLS2_k127_597852_6	278963.ATWD01000001_gene3851	2.179e-36	143.0	COG0537@1|root,COG0537@2|Bacteria,3Y542@57723|Acidobacteria,2JJT8@204432|Acidobacteriia	204432|Acidobacteriia	FG	PFAM Histidine triad (HIT) protein	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
TLS2_k127_597852_2	204669.Acid345_2208	1.418e-71	246.0	COG0302@1|root,COG0302@2|Bacteria,3Y2SP@57723|Acidobacteria,2JIR1@204432|Acidobacteriia	204432|Acidobacteriia	H	TIGRFAM GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
TLS2_k127_597852_9	1382359.JIAL01000001_gene1086	1.121e-09	71.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria,2JI1J@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
TLS2_k127_597852_5	240015.ACP_1740	7.773e-42	162.0	COG2121@1|root,COG2121@2|Bacteria,3Y4VJ@57723|Acidobacteria,2JJE4@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
TLS2_k127_597852_4	1201290.M902_2114	2.215e-44	171.0	COG0287@1|root,COG0287@2|Bacteria,1QA4K@1224|Proteobacteria,42V3B@68525|delta/epsilon subdivisions,2WRIN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K00210	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,PDH
TLS2_k127_597852_8	1340493.JNIF01000003_gene1946	2.22e-28	123.0	COG2006@1|root,COG2006@2|Bacteria,3Y7N1@57723|Acidobacteria	57723|Acidobacteria	S	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
TLS2_k127_597852_1	246197.MXAN_2574	3.052e-72	252.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,42REG@68525|delta/epsilon subdivisions,2WNK2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DUF208,RNase_HII
TLS2_k127_5991301_17	234267.Acid_0393	1.5e-42	160.0	COG1913@1|root,COG1913@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
TLS2_k127_5991301_0	234267.Acid_0394	7.819e-214	672.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02481,ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_5991301_8	234267.Acid_0398	6.285e-77	267.0	COG0509@1|root,COG0509@2|Bacteria	2|Bacteria	E	glycine decarboxylation via glycine cleavage system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H,Response_reg
TLS2_k127_5991301_1	234267.Acid_0399	3.821e-195	616.0	COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria	2|Bacteria	C	Polysulphide reductase, NrfD	qrcD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
TLS2_k127_5991301_6	177437.HRM2_18950	1.177e-95	319.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2MI6N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	qrcC	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
TLS2_k127_5991301_11	335543.Sfum_0610	2.617e-70	264.0	COG0243@1|root,COG0243@2|Bacteria,1R4RR@1224|Proteobacteria,42PA5@68525|delta/epsilon subdivisions,2WM0K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	qrcB	-	-	ko:K08357	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10150	RC03109	ko00000,ko00001,ko02000	5.A.3.10	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TLS2_k127_5991301_13	234267.Acid_0402	5.679e-63	221.0	COG3474@1|root,COG3474@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrom_CIII,Cytochrome_C7,GSDH
TLS2_k127_5991301_14	234267.Acid_0403	8.488e-62	224.0	COG0509@1|root,COG0509@2|Bacteria	2|Bacteria	E	glycine decarboxylation via glycine cleavage system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H,Response_reg
TLS2_k127_5991301_9	1047013.AQSP01000139_gene2339	2.223e-73	254.0	COG2836@1|root,COG2836@2|Bacteria	2|Bacteria	K	Biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
TLS2_k127_5991301_2	1382306.JNIM01000001_gene1966	1.205e-188	601.0	COG0076@1|root,COG0076@2|Bacteria,2G7N6@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28,4.1.2.27	ko:K01593,ko:K01634	ko00350,ko00360,ko00380,ko00600,ko00901,ko00950,ko00965,ko01100,ko01110,ko04071,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00600,map00901,map00950,map00965,map01100,map01110,map04071,map04726,map04728,map05030,map05031,map05034	M00037,M00042,M00100	R00685,R00699,R00736,R02080,R02464,R02701,R04909,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS2_k127_5991301_15	926550.CLDAP_09840	1.42e-53	193.0	COG0633@1|root,COG0633@2|Bacteria	2|Bacteria	C	Ferredoxin	fdx5	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
TLS2_k127_5991301_12	118168.MC7420_7794	5.618e-64	231.0	COG0469@1|root,COG0469@2|Bacteria,1G1KV@1117|Cyanobacteria	2|Bacteria	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK
TLS2_k127_5991301_19	1047013.AQSP01000138_gene1046	7.649e-34	145.0	COG3307@1|root,COG3307@2|Bacteria,2NQ25@2323|unclassified Bacteria	2|Bacteria	M	O-Antigen ligase	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	Wzy_C
TLS2_k127_5991301_3	530564.Psta_2420	2.062e-160	518.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_5991301_18	595460.RRSWK_06263	9.171e-40	169.0	COG1413@1|root,COG1413@2|Bacteria,2IZE1@203682|Planctomycetes	203682|Planctomycetes	C	E-Z type HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
TLS2_k127_5991301_16	1403819.BATR01000114_gene3948	8.068e-52	196.0	COG1477@1|root,COG1477@2|Bacteria,46VJI@74201|Verrucomicrobia,2IW89@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	ApbE family	-	-	-	-	-	-	-	-	-	-	-	-	ApbE
TLS2_k127_5991301_10	452637.Oter_3514	2.719e-73	253.0	2F286@1|root,33V6C@2|Bacteria,46V8R@74201|Verrucomicrobia,3K9H5@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5991301_7	1396418.BATQ01000117_gene4548	5.053e-85	301.0	COG4745@1|root,COG4745@2|Bacteria,46T45@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_5991301_24	465541.ATCJ01000005_gene7119	0.0004509	46.0	2BFRC@1|root,329K5@2|Bacteria,2GRGJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5991301_22	1278073.MYSTI_03857	8.566e-11	67.0	COG3409@1|root,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
TLS2_k127_5991301_21	1173028.ANKO01000018_gene1170	1.042e-15	89.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria	2|Bacteria	O	protein N-acetylglucosaminyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
TLS2_k127_5991301_20	335543.Sfum_0084	1.284e-27	117.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42UQP@68525|delta/epsilon subdivisions,2WQKU@28221|Deltaproteobacteria,2MS96@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
TLS2_k127_5991301_4	1476583.DEIPH_ctg020orf0011	1.485e-115	383.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	rfaF	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TLS2_k127_5991301_5	479434.Sthe_3171	1.337e-96	328.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	rfaF	-	-	ko:K02843,ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TLS2_k127_5995538_3	1279019.ARQK01000049_gene30	2.179e-36	145.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria	1224|Proteobacteria	T	Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_1238	Peptidase_M48
TLS2_k127_5995538_5	96561.Dole_2317	4.21e-13	70.0	2EFZF@1|root,339RM@2|Bacteria,1NH6S@1224|Proteobacteria,42WYZ@68525|delta/epsilon subdivisions,2WT48@28221|Deltaproteobacteria,2MPCB@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5995538_0	1254432.SCE1572_51025	6.866e-74	263.0	COG0438@1|root,COG0438@2|Bacteria,1Q3IF@1224|Proteobacteria,43794@68525|delta/epsilon subdivisions,2WTY0@28221|Deltaproteobacteria,2YWM7@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_5995538_2	926560.KE387023_gene2470	6.01e-45	172.0	COG3685@1|root,COG3685@2|Bacteria,1WKD4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Domain of unknown function (DUF892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF892
TLS2_k127_5995538_1	1121033.AUCF01000005_gene5299	1.323e-57	201.0	COG3408@1|root,COG3408@2|Bacteria,1MW01@1224|Proteobacteria,2U38G@28211|Alphaproteobacteria,2JRNY@204441|Rhodospirillales	204441|Rhodospirillales	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
TLS2_k127_5996316_0	1128421.JAGA01000003_gene3230	8.333e-237	750.0	COG0567@1|root,COG0567@2|Bacteria,2NQJV@2323|unclassified Bacteria	2|Bacteria	C	Dehydrogenase E1 component	sucA	GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
TLS2_k127_5996316_2	1128421.JAGA01000003_gene3230	1.312e-72	251.0	COG0567@1|root,COG0567@2|Bacteria,2NQJV@2323|unclassified Bacteria	2|Bacteria	C	Dehydrogenase E1 component	sucA	GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
TLS2_k127_5996316_1	1051632.TPY_1624	4.291e-118	393.0	COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,247Q5@186801|Clostridia	186801|Clostridia	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12,2.3.1.168,2.3.1.61	ko:K00627,ko:K00658,ko:K09699	ko00010,ko00020,ko00280,ko00310,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00310,map00620,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00036,M00307	R00209,R02569,R02570,R02571,R02662,R03174,R04097,R08549,R10998	RC00004,RC02727,RC02742,RC02833,RC02857,RC02870	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,CMD,E3_binding
TLS2_k127_5996316_3	945713.IALB_3055	1.219e-54	205.0	COG1376@1|root,COG1376@2|Bacteria	2|Bacteria	D	ErfK ybiS ycfS ynhG family protein	enhA_1	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,YkuD
TLS2_k127_5996316_4	1429916.X566_21020	3.947e-18	87.0	COG0652@1|root,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
TLS2_k127_6017740_0	1267535.KB906767_gene4834	2.472e-145	467.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4832,Glyco_hydro_14,Glyco_hydro_42,Glyco_hydro_42M
TLS2_k127_6017740_2	697281.Mahau_2080	1.132e-20	104.0	COG0407@1|root,COG0407@2|Bacteria,1V7NA@1239|Firmicutes,24MGR@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TLS2_k127_6017740_1	1499967.BAYZ01000184_gene4601	1.075e-20	104.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TLS2_k127_6027319_0	382464.ABSI01000017_gene54	3.861e-237	748.0	COG3250@1|root,COG3250@2|Bacteria,46TYC@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Glycosyl hydrolases family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_N
TLS2_k127_6032618_2	234267.Acid_4205	2.775e-85	297.0	COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria	57723|Acidobacteria	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
TLS2_k127_6032618_1	204669.Acid345_2603	5.074e-144	475.0	COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria,2JP3M@204432|Acidobacteriia	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_6032618_0	234267.Acid_4207	5.99e-173	553.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria	57723|Acidobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_6032618_3	204669.Acid345_2605	3.371e-42	161.0	COG1913@1|root,COG1913@2|Bacteria,3Y880@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M54	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
TLS2_k127_6038755_2	234267.Acid_7897	1.224e-37	146.0	COG3303@1|root,COG3303@2|Bacteria,3Y84F@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6038755_1	621372.ACIH01000001_gene490	7.784e-89	311.0	COG1232@1|root,COG1232@2|Bacteria,1TQ6W@1239|Firmicutes,4HAUG@91061|Bacilli,26RYF@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemY	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS09325	Amino_oxidase
TLS2_k127_6038755_0	552811.Dehly_0435	1.819e-116	386.0	COG1138@1|root,COG1138@2|Bacteria,2G5SZ@200795|Chloroflexi	200795|Chloroflexi	O	PFAM Cytochrome C assembly protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
TLS2_k127_6048611_2	314265.R2601_09370	2.046e-18	87.0	COG2010@1|root,COG2010@2|Bacteria,1NAGW@1224|Proteobacteria,2UCCK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG2010 Cytochrome c, mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
TLS2_k127_6048611_0	671143.DAMO_1046	1.529e-33	138.0	COG4747@1|root,COG4747@2|Bacteria,2NR4R@2323|unclassified Bacteria	2|Bacteria	S	ACT domain protein	hom	-	1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19	ko:K00003,ko:K00058,ko:K01754,ko:K04767	ko00260,ko00270,ko00290,ko00300,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00017,M00018,M00020,M00570	R00220,R00996,R01513,R01773,R01775	RC00031,RC00087,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3
TLS2_k127_6048611_1	869210.Marky_1921	4.632e-27	117.0	COG0517@1|root,COG5485@1|root,COG0517@2|Bacteria,COG5485@2|Bacteria,1WK3F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_6048611_4	591159.ACEZ01000226_gene1209	2.611e-10	73.0	2DUW5@1|root,33SNU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6048611_5	349966.DJ58_1745	9.088e-09	59.0	COG0582@1|root,COG4644@1|root,COG0582@2|Bacteria,COG4644@2|Bacteria,1MUIU@1224|Proteobacteria,1RPZZ@1236|Gammaproteobacteria,41FXH@629|Yersinia	1236|Gammaproteobacteria	L	Domain of unknown function (DUF4158)	tnpA	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_Tn3,DUF4158
TLS2_k127_6057850_3	1210884.HG799464_gene10641	2.749e-34	143.0	COG1413@1|root,COG2010@1|root,COG2133@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,2IXPU@203682|Planctomycetes	203682|Planctomycetes	C	heme-binding domain, Pirellula Verrucomicrobium type	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,HEAT_2
TLS2_k127_6057850_5	288000.BBta_4719	7.591e-08	57.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,3JVP4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_6057850_1	1232410.KI421426_gene1450	3.564e-103	346.0	COG3021@1|root,COG3021@2|Bacteria,1MWFK@1224|Proteobacteria,42QIQ@68525|delta/epsilon subdivisions,2WM7F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_6057850_0	180332.JTGN01000009_gene4254	8.048e-147	472.0	COG2115@1|root,COG2115@2|Bacteria,1TQW2@1239|Firmicutes,24869@186801|Clostridia	186801|Clostridia	G	Belongs to the xylose isomerase family	xylA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS08960	AP_endonuc_2
TLS2_k127_6057850_4	240016.ABIZ01000001_gene2706	5.673e-26	114.0	COG0526@1|root,COG0526@2|Bacteria,46TGF@74201|Verrucomicrobia,2IW4P@203494|Verrucomicrobiae	203494|Verrucomicrobiae	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_6057850_2	1047013.AQSP01000142_gene209	6.188e-79	278.0	COG1629@1|root,COG4771@2|Bacteria,2NR02@2323|unclassified Bacteria	2|Bacteria	P	TonB dependent receptor	-	-	-	ko:K16089	-	-	-	-	ko00000,ko02000	1.B.14.1,1.B.14.10	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
TLS2_k127_6060707_2	1267535.KB906767_gene4699	1.519e-54	193.0	COG4447@1|root,COG4447@2|Bacteria,3Y2MX@57723|Acidobacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
TLS2_k127_6060707_1	313628.LNTAR_01300	9.899e-79	275.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
TLS2_k127_6060707_3	1185876.BN8_03498	4.456e-46	171.0	COG0251@1|root,COG0251@2|Bacteria,4NR3V@976|Bacteroidetes,47QRJ@768503|Cytophagia	976|Bacteroidetes	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
TLS2_k127_6060707_0	1042377.AFPJ01000028_gene2288	1.937e-173	556.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria,466AY@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_7
TLS2_k127_6064147_2	1268240.ATFI01000008_gene2165	3.068e-72	247.0	COG1908@1|root,COG1908@2|Bacteria,4P2UN@976|Bacteroidetes,2FRM5@200643|Bacteroidia,4AQ39@815|Bacteroidaceae	976|Bacteroidetes	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
TLS2_k127_6064147_0	1268240.ATFI01000008_gene2164	0.0	1086.0	COG1148@1|root,COG1148@2|Bacteria,4NI95@976|Bacteroidetes,2FRRV@200643|Bacteroidia,4ANZK@815|Bacteroidaceae	976|Bacteroidetes	C	Glucose inhibited division protein A	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Fer4,Fer4_7,HI0933_like,Pyr_redox_2
TLS2_k127_6064147_1	903818.KI912268_gene2572	4.817e-99	331.0	COG2048@1|root,COG2048@2|Bacteria	2|Bacteria	C	Heterodisulfide reductase, subunit B	hdrB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer4_17,Fer4_9
TLS2_k127_6064147_4	903818.KI912268_gene2571	3.788e-54	198.0	COG1150@1|root,COG1150@2|Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hdrC	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389,ko:K03390,ko:K16887,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3424	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8,Fer4_9
TLS2_k127_6064147_3	56780.SYN_00535	5.695e-56	201.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42R4C@68525|delta/epsilon subdivisions,2WKG9@28221|Deltaproteobacteria,2MS0Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
TLS2_k127_6064147_5	382464.ABSI01000011_gene2923	9.709e-54	197.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	ant1	-	2.7.7.47	ko:K00984,ko:K19279	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	DUF4111,NTP_transf_2,UPF0158
TLS2_k127_6064147_6	1231241.Mc24_06663	2.308e-17	87.0	COG1512@1|root,COG1512@2|Bacteria,2GDT8@200918|Thermotogae	200918|Thermotogae	S	Methanol dehydrogenase	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
TLS2_k127_6065525_0	1499967.BAYZ01000196_gene3073	6.839e-132	434.0	COG2379@1|root,COG2379@2|Bacteria,2NNQP@2323|unclassified Bacteria	2|Bacteria	G	MOFRL family	ttuD	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
TLS2_k127_6065525_1	266117.Rxyl_1977	1.597e-55	205.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2GMJZ@201174|Actinobacteria,4CU1Q@84995|Rubrobacteria	84995|Rubrobacteria	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107,4.2.1.75	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
TLS2_k127_6065525_2	1485544.JQKP01000002_gene1609	4.44e-12	68.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2VHT4@28216|Betaproteobacteria,44V8C@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
TLS2_k127_6066258_2	452637.Oter_3063	3.338e-106	349.0	COG3408@1|root,COG3408@2|Bacteria,46U0C@74201|Verrucomicrobia,3K76I@414999|Opitutae	414999|Opitutae	G	Alpha-L-rhamnosidase N-terminal domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
TLS2_k127_6066258_1	1183438.GKIL_4354	2.973e-118	409.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_6066258_0	234267.Acid_2606	6.283e-251	784.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	celD	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0016052,GO:0016787,GO:0016798,GO:0033946,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0052736,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Calycin_like,CelD_N,DUF1080,Glyco_hydro_9,PCMD
TLS2_k127_6066258_3	1191523.MROS_2623	2.359e-21	95.0	COG4124@1|root,COG4124@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 26 family	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Glyco_hydro_26
TLS2_k127_6069208_1	1869.MB27_27405	7.971e-11	75.0	COG0388@1|root,COG0388@2|Bacteria,2GKRJ@201174|Actinobacteria,4D96X@85008|Micromonosporales	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
TLS2_k127_6069208_0	344747.PM8797T_06380	4.286e-28	131.0	COG0388@1|root,COG0388@2|Bacteria,2IXSE@203682|Planctomycetes	203682|Planctomycetes	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS2_k127_6076755_3	247490.KSU1_C0085	1.654e-59	208.0	COG0225@1|root,COG0225@2|Bacteria,2IZ67@203682|Planctomycetes	203682|Planctomycetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS2_k127_6076755_0	761193.Runsl_4236	5.195e-131	434.0	COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,47K7H@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_6076755_1	370438.PTH_0615	2.176e-104	346.0	COG0846@1|root,COG0846@2|Bacteria,1TQB7@1239|Firmicutes	1239|Firmicutes	K	COG COG0846 NAD-dependent protein deacetylases, SIR2 family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6076755_2	761193.Runsl_2560	1.962e-87	300.0	COG3828@1|root,COG3828@2|Bacteria,4PNCT@976|Bacteroidetes,47NTF@768503|Cytophagia	976|Bacteroidetes	S	Methane oxygenase PmoA	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
TLS2_k127_6076755_5	545694.TREPR_3798	3.572e-49	185.0	COG0145@1|root,COG0145@2|Bacteria,2JAMB@203691|Spirochaetes	203691|Spirochaetes	EQ	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
TLS2_k127_6076755_4	1415780.JPOG01000001_gene2500	9.833e-57	209.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R9SN@1224|Proteobacteria,1SFN0@1236|Gammaproteobacteria,1X7VP@135614|Xanthomonadales	135614|Xanthomonadales	K	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2,MerR_1
TLS2_k127_6076755_6	1219375.CM002139_gene2869	3.502e-14	72.0	COG2155@1|root,COG2155@2|Bacteria,1N77I@1224|Proteobacteria,1SHMF@1236|Gammaproteobacteria,1XB8D@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF378)	-	-	-	ko:K09779	-	-	-	-	ko00000	-	-	-	DUF378
TLS2_k127_607700_1	228410.NE0823	1.326e-33	131.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2VKEE@28216|Betaproteobacteria,372CG@32003|Nitrosomonadales	28216|Betaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14
TLS2_k127_607700_4	768671.ThimaDRAFT_1313	3.347e-26	112.0	COG1487@1|root,COG1487@2|Bacteria,1RHQJ@1224|Proteobacteria,1TKC4@1236|Gammaproteobacteria,1X1S9@135613|Chromatiales	135613|Chromatiales	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_607700_5	330214.NIDE0652	1.221e-09	63.0	2EC1X@1|root,33GB5@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K21495	-	-	-	-	ko00000,ko02048	-	-	-	-
TLS2_k127_607700_2	1266909.AUAG01000018_gene311	9.302e-29	128.0	2E58T@1|root,33017@2|Bacteria,1NFNZ@1224|Proteobacteria,1SSK5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterised protein family (UPF0158)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0158
TLS2_k127_607700_0	1121374.KB891589_gene55	6.017e-107	354.0	COG3410@1|root,COG3410@2|Bacteria,1PRQ3@1224|Proteobacteria,1RR13@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized conserved protein (DUF2075)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2075
TLS2_k127_6078779_2	742821.HMPREF9464_01168	4.561e-32	133.0	COG2186@1|root,COG2186@2|Bacteria,1PK6X@1224|Proteobacteria,2W8G8@28216|Betaproteobacteria,4PQNN@995019|Sutterellaceae	28216|Betaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_6078779_0	471854.Dfer_1896	7.428e-104	344.0	COG3836@1|root,COG3836@2|Bacteria,4NKKD@976|Bacteroidetes,47TAP@768503|Cytophagia	976|Bacteroidetes	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_6078779_4	1033743.CAES01000009_gene1902	3.032e-12	71.0	COG0673@1|root,COG0673@2|Bacteria,1VYE1@1239|Firmicutes,4HXAY@91061|Bacilli	91061|Bacilli	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_6078779_1	1123242.JH636435_gene2817	8.516e-70	256.0	COG0591@1|root,COG0591@2|Bacteria,2J2U0@203682|Planctomycetes	203682|Planctomycetes	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_6078883_2	1123242.JH636435_gene769	3.941e-11	67.0	2DBNR@1|root,2ZA54@2|Bacteria,2IYX9@203682|Planctomycetes	203682|Planctomycetes	S	Methane oxygenase PmoA	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
TLS2_k127_6078883_1	886293.Sinac_0920	1.268e-98	339.0	COG0673@1|root,COG0673@2|Bacteria,2IWZW@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_6078883_0	861299.J421_5653	2.784e-118	393.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_6085779_0	468059.AUHA01000002_gene1259	2.011e-146	473.0	COG2936@1|root,COG2936@2|Bacteria,4NFFB@976|Bacteroidetes,1IPID@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
TLS2_k127_6085779_2	589865.DaAHT2_2624	3.87e-55	201.0	COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,43B7V@68525|delta/epsilon subdivisions,2X6MA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Lipocalin / cytosolic fatty-acid binding protein family	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
TLS2_k127_6085779_1	1120746.CCNL01000005_gene108	1.532e-136	447.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2NPG9@2323|unclassified Bacteria	2|Bacteria	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	cdr	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
TLS2_k127_6086315_0	1173028.ANKO01000017_gene231	4.7e-322	997.0	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria,1H81U@1150|Oscillatoriales	1117|Cyanobacteria	CJ	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
TLS2_k127_6086315_1	251229.Chro_4403	1.127e-286	899.0	COG0068@1|root,COG0068@2|Bacteria,1G063@1117|Cyanobacteria,3VI6E@52604|Pleurocapsales	1117|Cyanobacteria	O	PFAM HypF finger	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
TLS2_k127_6086315_3	497965.Cyan7822_0631	1.23e-23	106.0	COG0298@1|root,COG0298@2|Bacteria,1G9FZ@1117|Cyanobacteria,3KIER@43988|Cyanothece	1117|Cyanobacteria	O	PFAM hydrogenase expression formation protein (HUPF HYPC)	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
TLS2_k127_6086315_2	518766.Rmar_2595	1.374e-173	553.0	COG0409@1|root,COG0409@2|Bacteria,4NIM8@976|Bacteroidetes	976|Bacteroidetes	O	TIGRFAM hydrogenase expression formation protein HypD	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
TLS2_k127_6086315_4	686340.Metal_1167	2.608e-19	91.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,1XDNY@135618|Methylococcales	135618|Methylococcales	O	hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
TLS2_k127_6087303_0	794903.OPIT5_10570	2.512e-106	355.0	COG3250@1|root,COG3250@2|Bacteria,46YAN@74201|Verrucomicrobia,3K989@414999|Opitutae	414999|Opitutae	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6087303_1	1408473.JHXO01000012_gene421	1.148e-87	296.0	COG2133@1|root,COG2133@2|Bacteria,4PMXZ@976|Bacteroidetes,2G0K9@200643|Bacteroidia	976|Bacteroidetes	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_6093190_1	266117.Rxyl_0426	2.403e-143	466.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4CRYD@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_6093190_0	509635.N824_19540	4.504e-179	572.0	COG1233@1|root,COG1233@2|Bacteria,4NF31@976|Bacteroidetes,1IR8I@117747|Sphingobacteriia	976|Bacteroidetes	Q	COG1233 Phytoene dehydrogenase and related	pys	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS2_k127_6105506_1	1128421.JAGA01000002_gene1321	1.394e-81	282.0	COG1597@1|root,COG1597@2|Bacteria,2NR9K@2323|unclassified Bacteria	2|Bacteria	I	Diacylglycerol kinase catalytic domain (presumed)	dagK	GO:0003674,GO:0003824,GO:0004143,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
TLS2_k127_6105506_2	926566.Terro_3759	1.541e-35	150.0	COG0673@1|root,COG0673@2|Bacteria,3Y3V4@57723|Acidobacteria,2JI4A@204432|Acidobacteriia	204432|Acidobacteriia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_6105506_0	314230.DSM3645_22174	3.965e-141	460.0	COG2081@1|root,COG2081@2|Bacteria,2IWW4@203682|Planctomycetes	203682|Planctomycetes	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
TLS2_k127_6105506_3	1123274.KB899411_gene3184	4.157e-21	95.0	COG0451@1|root,COG0451@2|Bacteria,2J5DY@203691|Spirochaetes	203691|Spirochaetes	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_6118698_0	518766.Rmar_1529	1.138e-68	245.0	COG2094@1|root,COG2094@2|Bacteria,4NP22@976|Bacteroidetes,1FJ9P@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	Belongs to the DNA glycosylase MPG family	mpg	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
TLS2_k127_6118698_1	861299.J421_5616	5.313e-63	225.0	28J3W@1|root,2Z900@2|Bacteria	2|Bacteria	S	NIPSNAP family containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
TLS2_k127_6118698_2	1267535.KB906767_gene3861	3.068e-55	198.0	COG4103@1|root,COG4103@2|Bacteria	2|Bacteria	T	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
TLS2_k127_6118698_3	204669.Acid345_0913	1.436e-06	56.0	COG2304@1|root,COG2304@2|Bacteria,3Y98A@57723|Acidobacteria,2JP4V@204432|Acidobacteriia	204432|Acidobacteriia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_612114_1	926566.Terro_3763	8.989e-45	171.0	COG0252@1|root,COG0252@2|Bacteria,3Y8TG@57723|Acidobacteria	57723|Acidobacteria	EJ	Asparaginase	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
TLS2_k127_612114_0	716928.AJQT01000049_gene1915	1.112e-111	366.0	COG3546@1|root,COG3546@2|Bacteria,1MUHB@1224|Proteobacteria,2TUU8@28211|Alphaproteobacteria,4BD7C@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Catalase	katN	-	-	ko:K07217	-	-	-	-	ko00000	-	-	-	DUF892,Mn_catalase
TLS2_k127_6127299_0	204669.Acid345_0920	3.739e-210	664.0	COG0457@1|root,COG0457@2|Bacteria,3Y3HT@57723|Acidobacteria,2JHSD@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS2_k127_6127299_6	316067.Geob_1175	7.371e-35	143.0	COG0484@1|root,COG0484@2|Bacteria,1N40E@1224|Proteobacteria,42UFJ@68525|delta/epsilon subdivisions,2WQAY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6127299_3	1192034.CAP_6081	3.184e-120	397.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42NW8@68525|delta/epsilon subdivisions,2WJY1@28221|Deltaproteobacteria,2YV62@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase E1 component	bkdA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS2_k127_6127299_1	404589.Anae109_1994	3.526e-153	489.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42N06@68525|delta/epsilon subdivisions,2WK5N@28221|Deltaproteobacteria,2YTX4@29|Myxococcales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	bkdB	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K00167	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_6127299_4	378806.STAUR_4668	2.37e-112	375.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,42MYB@68525|delta/epsilon subdivisions,2WIUY@28221|Deltaproteobacteria,2YU5E@29|Myxococcales	28221|Deltaproteobacteria	C	acetyltransferase component of pyruvate dehydrogenase complex	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_6127299_5	743721.Psesu_2392	4.25e-43	167.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1X36H@135614|Xanthomonadales	135614|Xanthomonadales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
TLS2_k127_6127299_7	521719.ATXQ01000001_gene626	2.617e-33	140.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1YF19@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	Methylates ribosomal protein L11	prmA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006480,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018011,GO:0018012,GO:0018022,GO:0018023,GO:0018193,GO:0018194,GO:0018205,GO:0019538,GO:0031365,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
TLS2_k127_6127299_2	234267.Acid_0734	4.638e-132	431.0	COG0484@1|root,COG0484@2|Bacteria,3Y33I@57723|Acidobacteria	57723|Acidobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_6127299_8	748449.Halha_1899	1.567e-16	81.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,3WAT6@53433|Halanaerobiales	186801|Clostridia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS2_k127_612935_0	338963.Pcar_2345	1.087e-109	361.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,43TKB@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_612935_1	1144275.COCOR_03386	2.617e-83	286.0	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,42Q4U@68525|delta/epsilon subdivisions,2WJ08@28221|Deltaproteobacteria,2YV00@29|Myxococcales	28221|Deltaproteobacteria	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_612935_3	378806.STAUR_6189	5.185e-37	141.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,42TPZ@68525|delta/epsilon subdivisions,2WQ0P@28221|Deltaproteobacteria,2YVRR@29|Myxococcales	28221|Deltaproteobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
TLS2_k127_612935_2	1267533.KB906739_gene2555	1.177e-60	213.0	COG1185@1|root,COG1185@2|Bacteria,3Y2UG@57723|Acidobacteria,2JI5F@204432|Acidobacteriia	204432|Acidobacteriia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TLS2_k127_6166422_2	1382359.JIAL01000001_gene1357	2.239e-140	453.0	COG1220@1|root,COG1220@2|Bacteria,3Y2K2@57723|Acidobacteria,2JIS7@204432|Acidobacteriia	204432|Acidobacteriia	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
TLS2_k127_6166422_4	1047013.AQSP01000121_gene2717	3.41e-69	240.0	COG5405@1|root,COG5405@2|Bacteria,2NP72@2323|unclassified Bacteria	2|Bacteria	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
TLS2_k127_6166422_1	717231.Flexsi_1169	4.551e-156	508.0	COG0029@1|root,COG0029@2|Bacteria,2GF9T@200930|Deferribacteres	200930|Deferribacteres	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_6166422_3	429009.Adeg_0107	7.155e-127	417.0	COG0498@1|root,COG0498@2|Bacteria,1TP25@1239|Firmicutes,25B08@186801|Clostridia	186801|Clostridia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_6166422_0	1407650.BAUB01000003_gene965	9.085e-176	577.0	COG2304@1|root,COG2304@2|Bacteria,1G3PE@1117|Cyanobacteria,1H2SF@1129|Synechococcus	1117|Cyanobacteria	S	Domain of unknown function (DUF3520)	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
TLS2_k127_6171443_0	671143.DAMO_2372	4.307e-82	282.0	COG0778@1|root,COG0778@2|Bacteria,2NPP2@2323|unclassified Bacteria	2|Bacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_6171443_2	479432.Sros_3771	7.64e-10	66.0	2BNAB@1|root,32GXX@2|Bacteria,2HF1P@201174|Actinobacteria,4EPYI@85012|Streptosporangiales	201174|Actinobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_6171443_1	903818.KI912268_gene3047	1.122e-50	184.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TLS2_k127_6171443_3	931627.MycrhDRAFT_1833	2.301e-05	53.0	COG1807@1|root,COG1807@2|Bacteria,2GNPY@201174|Actinobacteria	201174|Actinobacteria	M	capsule polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6180938_2	926550.CLDAP_32200	2.453e-62	224.0	COG0246@1|root,COG0246@2|Bacteria	2|Bacteria	G	mannitol metabolic process	-	-	1.1.1.17	ko:K00009	ko00051,map00051	-	R02703	RC00085	ko00000,ko00001,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
TLS2_k127_6180938_3	446468.Ndas_4221	3.055e-32	141.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4EI71@85012|Streptosporangiales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_6180938_1	1089550.ATTH01000001_gene269	2.635e-88	305.0	COG0508@1|root,COG0508@2|Bacteria,4NFB9@976|Bacteroidetes,1FIKE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_6180938_0	479434.Sthe_0229	4.517e-106	357.0	COG0022@1|root,COG0022@2|Bacteria,2G60F@200795|Chloroflexi,27Y12@189775|Thermomicrobia	200795|Chloroflexi	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_6190078_6	398767.Glov_1269	9.817e-06	54.0	COG3170@1|root,COG3170@2|Bacteria,1NHGQ@1224|Proteobacteria,42X64@68525|delta/epsilon subdivisions,2WSMQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	DUF2275,zf-HC2
TLS2_k127_6190078_1	1304880.JAGB01000002_gene2153	3.344e-32	134.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6190078_2	1304875.JAFZ01000001_gene717	4.362e-22	106.0	COG0760@1|root,COG0760@2|Bacteria,3TAT4@508458|Synergistetes	508458|Synergistetes	M	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase
TLS2_k127_6190078_4	443144.GM21_3457	7.112e-18	96.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,43T3R@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM peptidase S1 and S6, chymotrypsin Hap	degQ	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_6190078_0	1379270.AUXF01000006_gene164	5.481e-57	211.0	COG1974@1|root,COG1974@2|Bacteria,1ZSSM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
TLS2_k127_6190078_5	204669.Acid345_4724	2.782e-13	72.0	2EA3B@1|root,3348D@2|Bacteria,3Y5J1@57723|Acidobacteria,2JJZE@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6190078_3	335543.Sfum_2470	1.536e-21	96.0	COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,42SMU@68525|delta/epsilon subdivisions,2WP4P@28221|Deltaproteobacteria,2MRVA@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
TLS2_k127_6194874_6	639030.JHVA01000001_gene104	7.975e-61	220.0	COG3828@1|root,COG3828@2|Bacteria,3Y61V@57723|Acidobacteria	57723|Acidobacteria	S	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
TLS2_k127_6194874_0	1230476.C207_05261	5.148e-174	563.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2TU0C@28211|Alphaproteobacteria,3JRI4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K03319,ko:K09477,ko:K11106,ko:K14445	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.47,2.A.47.1,2.A.47.3.2,2.A.47.3.3	-	-	Na_sulph_symp
TLS2_k127_6194874_3	1054213.HMPREF9946_02772	3.311e-132	433.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TSBB@28211|Alphaproteobacteria,2JR9S@204441|Rhodospirillales	204441|Rhodospirillales	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.83,1.1.1.93,4.1.1.73	ko:K07246	ko00630,ko00650,map00630,map00650	-	R00215,R01751,R02545,R06180	RC00084,RC00105,RC00594	ko00000,ko00001,ko01000	-	-	-	Iso_dh
TLS2_k127_6194874_8	861299.J421_1542	3.797e-21	95.0	2A0AF@1|root,2ZQ9W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6194874_5	876044.IMCC3088_679	1.409e-98	329.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,1J4EY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Serine acetyltransferase	cysE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009314,GO:0009333,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
TLS2_k127_6194874_4	1267533.KB906737_gene2024	8.497e-110	363.0	COG0604@1|root,COG0604@2|Bacteria	2|Bacteria	C	NADPH:quinone reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
TLS2_k127_6194874_7	211165.AJLN01000104_gene6534	8.328e-56	205.0	COG2890@1|root,COG2890@2|Bacteria,1G51W@1117|Cyanobacteria,1JJCS@1189|Stigonemataceae	1117|Cyanobacteria	J	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_6194874_2	215803.DB30_3749	3.27e-142	467.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,42NR8@68525|delta/epsilon subdivisions,2WM9T@28221|Deltaproteobacteria,2YXV5@29|Myxococcales	28221|Deltaproteobacteria	M	Peptidase dimerisation domain	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_6194874_1	903818.KI912268_gene1954	1.15e-159	509.0	COG4581@1|root,COG4581@2|Bacteria	2|Bacteria	L	dead DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DUF3516,Helicase_C
TLS2_k127_6207505_0	1173023.KE650771_gene2604	4.034e-282	876.0	COG0028@1|root,COG0028@2|Bacteria,1G0KQ@1117|Cyanobacteria,1JJ9X@1189|Stigonemataceae	1117|Cyanobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_6210514_2	583355.Caka_0473	2.253e-70	245.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Calx-beta,DUF1080,F5_F8_type_C,PA14
TLS2_k127_6210514_3	861299.J421_3860	5.741e-62	217.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1572
TLS2_k127_6210514_1	1123368.AUIS01000013_gene853	3.49e-92	312.0	COG2084@1|root,COG2084@2|Bacteria,1P0X0@1224|Proteobacteria,1RPXF@1236|Gammaproteobacteria,2NCJ9@225057|Acidithiobacillales	225057|Acidithiobacillales	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_6210514_6	1173028.ANKO01000174_gene2675	1.248e-17	83.0	2EMYS@1|root,33FKY@2|Bacteria,1GF1P@1117|Cyanobacteria,1HGNZ@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF2795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2795
TLS2_k127_6210514_5	234267.Acid_2543	7.567e-18	95.0	COG1503@1|root,COG1503@2|Bacteria,3Y6P2@57723|Acidobacteria	57723|Acidobacteria	J	eRF1 domain 3	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach,eRF1_3
TLS2_k127_6210514_4	667014.Thein_0475	1.737e-24	115.0	COG1943@1|root,COG1943@2|Bacteria,2GI5R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
TLS2_k127_6210514_7	762903.Pedsa_1811	1.567e-15	84.0	COG3119@1|root,COG3119@2|Bacteria,4NP9D@976|Bacteroidetes	976|Bacteroidetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_6210514_0	203119.Cthe_2590	2.214e-135	443.0	COG3693@1|root,COG3693@2|Bacteria,1UHTC@1239|Firmicutes,248KD@186801|Clostridia,3WH8I@541000|Ruminococcaceae	186801|Clostridia	G	hydrolase family 10	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	CBM9_1,CBM_4_9,Glyco_hydro_10,SLH
TLS2_k127_6211916_2	1121085.AUCI01000001_gene3663	0.0005704	48.0	COG4818@1|root,COG4818@2|Bacteria,1VBIZ@1239|Firmicutes,4HKBZ@91061|Bacilli,1ZJCH@1386|Bacillus	91061|Bacilli	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
TLS2_k127_6211916_1	1341151.ASZU01000006_gene2908	1.676e-82	284.0	COG2103@1|root,COG2103@2|Bacteria,1TPSF@1239|Firmicutes,4HBWP@91061|Bacilli,27BJ1@186824|Thermoactinomycetaceae	91061|Bacilli	G	SIS domain	murQ	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS,SIS_2
TLS2_k127_6211916_0	204669.Acid345_1478	1.419e-105	353.0	COG0345@1|root,COG0345@2|Bacteria,3Y41B@57723|Acidobacteria,2JITZ@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
TLS2_k127_6215503_1	411477.PARMER_00170	2.141e-173	554.0	COG1554@1|root,COG1554@2|Bacteria,4NEWW@976|Bacteroidetes,2FMF9@200643|Bacteroidia,22W4V@171551|Porphyromonadaceae	976|Bacteroidetes	G	Glycosyl hydrolase family 65, N-terminal domain	-	-	3.2.1.51	ko:K15923	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	GH95	-	Glyco_hyd_65N_2
TLS2_k127_6215503_0	234267.Acid_3742	8.552e-280	881.0	COG3408@1|root,COG3408@2|Bacteria,3Y7ET@57723|Acidobacteria	57723|Acidobacteria	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_N
TLS2_k127_6215503_2	926550.CLDAP_19640	9.341e-59	209.0	COG1806@1|root,COG1806@2|Bacteria,2G8E0@200795|Chloroflexi	200795|Chloroflexi	S	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
TLS2_k127_6215879_3	1288963.ADIS_2076	1.533e-117	381.0	COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,47NH0@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_6215879_7	1232410.KI421417_gene2707	2.63e-48	181.0	COG2032@1|root,COG2032@2|Bacteria,1N26J@1224|Proteobacteria,43B8H@68525|delta/epsilon subdivisions,2X6MV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
TLS2_k127_6215879_5	929562.Emtol_0789	2.666e-91	309.0	COG0524@1|root,COG0524@2|Bacteria,4NENQ@976|Bacteroidetes,47MN5@768503|Cytophagia	976|Bacteroidetes	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS2_k127_6215879_1	649349.Lbys_0373	2.063e-135	438.0	COG4975@1|root,COG4975@2|Bacteria,4NF22@976|Bacteroidetes,47JEJ@768503|Cytophagia	976|Bacteroidetes	G	Sugar transport protein	glcU	-	-	ko:K05340	-	-	-	-	ko00000,ko02000	2.A.7.5	-	-	Ureide_permease
TLS2_k127_6215879_2	742726.HMPREF9448_02737	1.842e-127	425.0	COG1397@1|root,COG1397@2|Bacteria,4NG36@976|Bacteroidetes,2FNB7@200643|Bacteroidia,22X71@171551|Porphyromonadaceae	976|Bacteroidetes	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
TLS2_k127_6215879_0	247490.KSU1_C1633	2.112e-295	934.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,2IY2M@203682|Planctomycetes	203682|Planctomycetes	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TLS2_k127_6215879_4	204669.Acid345_2220	9.232e-101	337.0	COG1131@1|root,COG1131@2|Bacteria,3Y3I9@57723|Acidobacteria,2JIPJ@204432|Acidobacteriia	204432|Acidobacteriia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6215879_6	1267535.KB906767_gene1277	2.279e-74	260.0	COG0109@1|root,COG0109@2|Bacteria,3Y3VI@57723|Acidobacteria,2JIRB@204432|Acidobacteriia	204432|Acidobacteriia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
TLS2_k127_6240638_2	1128421.JAGA01000003_gene2875	2.017e-15	83.0	2EJZ3@1|root,33DPP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6240638_0	1128421.JAGA01000003_gene2874	1.264e-127	419.0	COG4531@1|root,COG4531@2|Bacteria,2NP5Y@2323|unclassified Bacteria	2|Bacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	actF	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6240638_1	204669.Acid345_3000	6.002e-50	181.0	COG2010@1|root,COG2010@2|Bacteria,3Y2MN@57723|Acidobacteria,2JI6T@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS2_k127_6242007_0	1340493.JNIF01000003_gene1861	1.537e-95	331.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,TonB_dep_Rec
TLS2_k127_6250790_3	945713.IALB_0449	7.771e-51	185.0	COG0040@1|root,COG0040@2|Bacteria	2|Bacteria	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	iECSF_1327.ECSF_1909	HisG,HisG_C
TLS2_k127_6250790_5	246194.CHY_1082	1.263e-23	104.0	COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,24MX9@186801|Clostridia,42GKT@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM TrpR like protein, YerC YecD	-	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
TLS2_k127_6250790_2	240015.ACP_0329	3.339e-136	441.0	COG1013@1|root,COG1013@2|Bacteria,3Y3NE@57723|Acidobacteria,2JIEM@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
TLS2_k127_6250790_0	1382359.JIAL01000001_gene135	3.868e-256	803.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,3Y3NX@57723|Acidobacteria,2JKIA@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
TLS2_k127_6250790_1	1382306.JNIM01000001_gene1354	1.635e-206	655.0	COG1012@1|root,COG1012@2|Bacteria,2G61H@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS2_k127_6250790_4	1117314.PCIT_02425	1.04e-35	145.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,2PZFP@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.200	ko:K02533,ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
TLS2_k127_6256503_3	880073.Calab_2036	2.082e-30	121.0	COG0493@1|root,COG0493@2|Bacteria,2NNXN@2323|unclassified Bacteria	2|Bacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2
TLS2_k127_6256503_1	330214.NIDE0204	2.653e-106	353.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,3J13F@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
TLS2_k127_6256503_2	868595.Desca_0381	1.339e-54	198.0	COG2606@1|root,COG2606@2|Bacteria	2|Bacteria	S	Cys-tRNA(Pro) hydrolase activity	ybaK	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0043906,GO:0043907,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
TLS2_k127_6256503_0	156889.Mmc1_1605	1.166e-198	641.0	COG3347@1|root,COG4221@1|root,COG3347@2|Bacteria,COG4221@2|Bacteria,1QVWU@1224|Proteobacteria,2TWVU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
TLS2_k127_6256503_4	1408322.JHYK01000017_gene1709	1.181e-21	99.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,27M6K@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TLS2_k127_6257002_2	1121124.JNIX01000004_gene123	1.105e-82	289.0	COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,2TTHW@28211|Alphaproteobacteria,2KK5S@204458|Caulobacterales	204458|Caulobacterales	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_6257002_3	234267.Acid_0669	2.326e-52	197.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS2_k127_6257002_4	1267535.KB906767_gene4919	9.592e-16	89.0	COG0745@1|root,COG0745@2|Bacteria,3Y67W@57723|Acidobacteria	57723|Acidobacteria	KT	RESPONSE REGULATOR receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6257002_5	439235.Dalk_3004	2.549e-14	78.0	COG2608@1|root,COG2608@2|Bacteria,1PUDD@1224|Proteobacteria,42XJ7@68525|delta/epsilon subdivisions,2WSKI@28221|Deltaproteobacteria,2MP4U@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Heavy-metal-associated domain	-	-	-	-	-	-	-	-	-	-	-	-	HMA
TLS2_k127_6257002_0	1121396.KB893012_gene4012	4.182e-272	860.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2MHN2@213118|Desulfobacterales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS2_k127_6257002_1	880073.Calab_3483	3.644e-106	351.0	COG3033@1|root,COG3033@2|Bacteria,2NNZV@2323|unclassified Bacteria	2|Bacteria	E	Beta-eliminating lyase	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_6273221_1	1122194.AUHU01000007_gene312	9.355e-28	112.0	28I5V@1|root,2Z891@2|Bacteria,1R3WS@1224|Proteobacteria,1RY0Y@1236|Gammaproteobacteria,465R4@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Cellulase N-terminal ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,Glyco_hydro_9
TLS2_k127_6273221_0	143224.JQMD01000002_gene257	2.961e-177	571.0	COG0673@1|root,COG0673@2|Bacteria,4NH96@976|Bacteroidetes,1I886@117743|Flavobacteriia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_6273221_2	1500890.JQNL01000001_gene3735	2.402e-09	68.0	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,1RMAD@1236|Gammaproteobacteria,1X4IS@135614|Xanthomonadales	135614|Xanthomonadales	V	COG1566 Multidrug resistance efflux pump	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_D23
TLS2_k127_6275795_0	742766.HMPREF9455_02491	4.155e-118	406.0	COG3250@1|root,COG3250@2|Bacteria,4NGNR@976|Bacteroidetes,2FPKM@200643|Bacteroidia,22ZS7@171551|Porphyromonadaceae	976|Bacteroidetes	G	Glycosyl hydrolases family 2, TIM barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TLS2_k127_6285830_0	1366046.HIMB11_00618	3.024e-102	346.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,3ZGXC@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	E	Methionine synthase II (cobalamin-independent)	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
TLS2_k127_6285830_1	1384057.CD33_13430	3.401e-18	97.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HF06@91061|Bacilli	91061|Bacilli	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_6304573_1	234267.Acid_6484	7.832e-72	250.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	macB_1	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_6304573_0	1123270.ATUR01000002_gene2330	4.823e-142	468.0	COG1649@1|root,COG1649@2|Bacteria,1NP4V@1224|Proteobacteria,2UDGK@28211|Alphaproteobacteria,2K1N8@204457|Sphingomonadales	204457|Sphingomonadales	S	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6
TLS2_k127_6314696_0	1499967.BAYZ01000159_gene477	2.623e-133	436.0	COG3214@1|root,COG3214@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	ycaQ	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
TLS2_k127_6314696_1	344747.PM8797T_03489	1.075e-99	338.0	COG0535@1|root,COG0535@2|Bacteria,2IXC0@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Radical_SAM
TLS2_k127_6314696_2	706587.Desti_3284	1.188e-60	218.0	COG0398@1|root,COG0398@2|Bacteria,1MVF3@1224|Proteobacteria,42R7A@68525|delta/epsilon subdivisions,2WN7K@28221|Deltaproteobacteria,2MQQS@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_6321319_0	204669.Acid345_0248	2.801e-28	123.0	COG4775@1|root,COG4775@2|Bacteria,3Y2Q9@57723|Acidobacteria,2JHYD@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM outer membrane protein assembly complex, YaeT protein	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TLS2_k127_6321319_1	1392488.JHZY01000002_gene739	4.421e-08	66.0	COG1305@1|root,COG1305@2|Bacteria,4NHV0@976|Bacteroidetes,1I7DH@117743|Flavobacteriia	976|Bacteroidetes	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
TLS2_k127_6331258_2	452637.Oter_3040	7.329e-79	273.0	COG2819@1|root,COG2819@2|Bacteria,46W78@74201|Verrucomicrobia,3K9WA@414999|Opitutae	74201|Verrucomicrobia	S	Putative esterase	-	-	-	ko:K07017	-	-	-	-	ko00000	-	-	-	Esterase
TLS2_k127_6331258_3	1267535.KB906767_gene1408	2.637e-69	246.0	COG0457@1|root,COG0457@2|Bacteria,3Y6HH@57723|Acidobacteria,2JNZ8@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6331258_0	1158294.JOMI01000004_gene3543	2.075e-115	380.0	COG3386@1|root,COG3386@2|Bacteria,4NF4A@976|Bacteroidetes,2FSDK@200643|Bacteroidia	976|Bacteroidetes	G	SMP-30 Gluconolaconase LRE-like	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pectate_lyase_3,SGL
TLS2_k127_6331258_1	1121396.KB893123_gene1084	7.391e-87	310.0	COG2197@1|root,COG2202@1|root,COG4585@1|root,COG2197@2|Bacteria,COG2202@2|Bacteria,COG4585@2|Bacteria,1NWNJ@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HATPase_c,HTH_3,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3
TLS2_k127_6340766_1	391937.NA2_01904	7.698e-13	78.0	COG3356@1|root,COG3356@2|Bacteria,1R4RH@1224|Proteobacteria,2U1KB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
TLS2_k127_6340766_0	234267.Acid_1509	2.541e-123	415.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6356227_1	926550.CLDAP_28000	8.235e-189	599.0	COG0626@1|root,COG0626@2|Bacteria,2G7Q6@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Cys Met metabolism pyridoxal-phosphate-dependent	-	-	4.4.1.11	ko:K01761	ko00270,ko00450,map00270,map00450	-	R00654,R04770	RC00196,RC00348,RC01209,RC01210	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
TLS2_k127_6356227_0	1487953.JMKF01000078_gene4104	1.183e-193	629.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7TU@1150|Oscillatoriales	1117|Cyanobacteria	T	COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,FHA,GAF,GGDEF,PAS,PAS_3,PAS_8,Response_reg
TLS2_k127_6366903_1	204669.Acid345_1455	3.112e-90	324.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
TLS2_k127_6366903_0	204669.Acid345_1052	9.678e-104	366.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
TLS2_k127_637095_0	1226322.HMPREF1545_01278	1.732e-60	222.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia,2N75P@216572|Oscillospiraceae	186801|Clostridia	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
TLS2_k127_637095_1	1267535.KB906767_gene4539	1.3e-06	58.0	COG2823@1|root,COG2823@2|Bacteria,3Y7ZV@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_637835_1	1396418.BATQ01000060_gene2064	1.755e-37	153.0	COG1621@1|root,COG4409@1|root,COG1621@2|Bacteria,COG4409@2|Bacteria,46U32@74201|Verrucomicrobia	74201|Verrucomicrobia	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
TLS2_k127_637835_0	1123242.JH636434_gene4951	1.336e-47	190.0	COG1621@1|root,COG1621@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 32 family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,Dockerin_1,HTH_18,RicinB_lectin_2
TLS2_k127_637835_2	1267535.KB906767_gene5144	1.025e-05	51.0	COG0363@1|root,COG0363@2|Bacteria,3Y51I@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glucosamine galactosamine-6-phosphate isomerase	-	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso
TLS2_k127_6425390_1	1382359.JIAL01000001_gene986	2.592e-77	267.0	COG0341@1|root,COG0341@2|Bacteria,3Y2ZT@57723|Acidobacteria,2JHZF@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_6425390_2	234267.Acid_1280	1.132e-53	198.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TLS2_k127_6425390_0	204669.Acid345_0149	2.878e-86	291.0	COG0811@1|root,COG0811@2|Bacteria,3Y2M4@57723|Acidobacteria,2JI9T@204432|Acidobacteriia	204432|Acidobacteriia	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
TLS2_k127_6425390_5	204669.Acid345_0150	1.804e-26	113.0	COG0848@1|root,COG0848@2|Bacteria,3Y4TE@57723|Acidobacteria,2JJKY@204432|Acidobacteriia	204432|Acidobacteriia	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS2_k127_6425390_4	1340493.JNIF01000003_gene1846	2.053e-31	128.0	COG0848@1|root,COG0848@2|Bacteria,3Y5AP@57723|Acidobacteria	57723|Acidobacteria	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS2_k127_6425390_3	1267533.KB906734_gene4317	3.452e-39	155.0	COG0457@1|root,COG0457@2|Bacteria,3Y3N5@57723|Acidobacteria,2JISD@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
TLS2_k127_6427954_1	234267.Acid_6704	4.457e-69	246.0	COG0621@1|root,COG0621@2|Bacteria,3Y2GT@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TLS2_k127_6427954_0	1499967.BAYZ01000178_gene4647	8.583e-70	247.0	COG0497@1|root,COG0497@2|Bacteria,2NNUS@2323|unclassified Bacteria	2|Bacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0000724,GO:0000725,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009295,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K03631,ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_23,SMC_N
TLS2_k127_6428142_4	429009.Adeg_1395	1.027e-22	104.0	COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,24HGQ@186801|Clostridia,42GDW@68295|Thermoanaerobacterales	186801|Clostridia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
TLS2_k127_6428142_1	1123371.ATXH01000003_gene1979	4.172e-168	537.0	COG0137@1|root,COG0137@2|Bacteria,2GGZY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
TLS2_k127_6428142_2	556268.OFAG_02000	6.529e-125	416.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,472JW@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
TLS2_k127_6428142_3	1047013.AQSP01000119_gene1309	1.814e-88	305.0	COG0078@1|root,COG0078@2|Bacteria,2NNWN@2323|unclassified Bacteria	2|Bacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_6428142_0	304371.MCP_1463	4.702e-169	539.0	COG0192@1|root,arCOG07444@2157|Archaea	2157|Archaea	H	S-adenosylmethionine synthetase, C-terminal domain	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
TLS2_k127_6432407_3	204669.Acid345_1596	4.671e-25	108.0	COG0218@1|root,COG0218@2|Bacteria,3Y4H6@57723|Acidobacteria,2JJC1@204432|Acidobacteriia	204432|Acidobacteriia	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
TLS2_k127_6432407_2	1340493.JNIF01000003_gene3800	3.123e-41	160.0	COG2823@1|root,COG2823@2|Bacteria	2|Bacteria	S	hyperosmotic response	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS2_k127_6432407_0	344747.PM8797T_07452	5.878e-64	228.0	COG2133@1|root,COG2133@2|Bacteria,2J537@203682|Planctomycetes	203682|Planctomycetes	G	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,ThuA
TLS2_k127_6432407_1	642492.Clole_0893	1.678e-51	196.0	COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia	186801|Clostridia	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
TLS2_k127_6432407_4	1121904.ARBP01000006_gene4028	2.659e-23	114.0	295NE@1|root,2ZSZT@2|Bacteria,4NPQK@976|Bacteroidetes	976|Bacteroidetes	S	DoxX	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
TLS2_k127_6434514_1	330214.NIDE4374	2.299e-46	171.0	COG1091@1|root,COG1091@2|Bacteria	2|Bacteria	M	dTDP-4-dehydrorhamnose reductase activity	rmlD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
TLS2_k127_6434514_0	330214.NIDE4377	9.972e-311	955.0	COG0488@1|root,COG0488@2|Bacteria,3J0WR@40117|Nitrospirae	40117|Nitrospirae	S	ABC transporter	-	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
TLS2_k127_6440060_1	1219035.NT2_02_02740	1.284e-40	152.0	COG1629@1|root,COG4771@2|Bacteria,1R4PY@1224|Proteobacteria,2U3FF@28211|Alphaproteobacteria,2K1WN@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
TLS2_k127_6440060_4	278963.ATWD01000001_gene2242	1.881e-08	57.0	2CDQT@1|root,342BP@2|Bacteria,3Y8AY@57723|Acidobacteria,2JNNG@204432|Acidobacteriia	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6440060_2	211165.AJLN01000149_gene6671	3.966e-31	128.0	COG1846@1|root,COG1846@2|Bacteria,1G8MU@1117|Cyanobacteria,1JM1T@1189|Stigonemataceae	1117|Cyanobacteria	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	MarR
TLS2_k127_6440060_3	266117.Rxyl_2706	5.509e-27	119.0	COG4319@1|root,COG4319@2|Bacteria,2HRVA@201174|Actinobacteria,4CTYP@84995|Rubrobacteria	84995|Rubrobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_6440060_0	926550.CLDAP_37020	2.832e-109	359.0	COG2746@1|root,COG2746@2|Bacteria,2G6YM@200795|Chloroflexi	200795|Chloroflexi	V	Aminoglycoside 3-N-acetyltransferase	-	-	2.3.1.81	ko:K00662	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Antibiotic_NAT
TLS2_k127_644458_1	1408473.JHXO01000009_gene3488	6.274e-90	302.0	COG0667@1|root,COG0667@2|Bacteria,4P42C@976|Bacteroidetes	976|Bacteroidetes	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_644458_0	240016.ABIZ01000001_gene2082	4.632e-178	572.0	COG1012@1|root,COG1012@2|Bacteria,46SIA@74201|Verrucomicrobia,2IU6F@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_644458_2	639030.JHVA01000001_gene3216	1.414e-78	267.0	COG3970@1|root,COG3970@2|Bacteria,3Y6J7@57723|Acidobacteria,2JKPG@204432|Acidobacteriia	204432|Acidobacteriia	S	Fumarylacetoacetate (FAA) hydrolase family	-	-	4.2.1.141	ko:K14259	ko00040,map00040	-	R09186	RC00429	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
TLS2_k127_6455447_1	709986.Deima_2332	8.96e-84	292.0	COG2268@1|root,COG2268@2|Bacteria	2|Bacteria	T	Band 7 protein	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
TLS2_k127_6455447_0	118168.MC7420_3554	2.548e-122	402.0	COG0464@1|root,COG0464@2|Bacteria,1G68X@1117|Cyanobacteria,1HBS8@1150|Oscillatoriales	1117|Cyanobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
TLS2_k127_6455447_2	1120973.AQXL01000116_gene310	4.847e-46	174.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,4HIMK@91061|Bacilli,278G7@186823|Alicyclobacillaceae	91061|Bacilli	D	Maf-like protein	maf	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0022402,GO:0022607,GO:0030428,GO:0032506,GO:0044085,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0090529,GO:1902410,GO:1903047	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
TLS2_k127_6455447_3	1348657.M622_08520	7.821e-37	141.0	COG0440@1|root,COG0440@2|Bacteria,1N065@1224|Proteobacteria,2VV2S@28216|Betaproteobacteria,2KWWN@206389|Rhodocyclales	206389|Rhodocyclales	E	Acetolactate synthase small	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5
TLS2_k127_6455447_4	882.DVU_0360	9.948e-21	92.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42MV2@68525|delta/epsilon subdivisions,2WJ7U@28221|Deltaproteobacteria,2M839@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_646656_1	886293.Sinac_6963	3.979e-50	184.0	COG3119@1|root,COG3119@2|Bacteria,2IXBI@203682|Planctomycetes	203682|Planctomycetes	P	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_646656_2	926560.KE387023_gene1920	2.576e-45	188.0	COG2374@1|root,COG2374@2|Bacteria,1WM95@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	U	PFAM Endonuclease Exonuclease phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Exo_endo_phos,LTD
TLS2_k127_646656_0	1340493.JNIF01000003_gene4476	7.439e-56	221.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	ko:K07004,ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	ASH,CHU_C,DUF11,SGL
TLS2_k127_646656_5	1550073.JROH01000045_gene2971	6.458e-05	56.0	COG3568@1|root,COG3568@2|Bacteria,1QVCK@1224|Proteobacteria,2TXEF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_646656_3	671143.DAMO_1338	1.523e-17	89.0	COG1662@1|root,COG1662@2|Bacteria	2|Bacteria	L	PFAM IS1 transposase	-	-	-	ko:K07480	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1,DDE_Tnp_IS240
TLS2_k127_646656_4	1267535.KB906767_gene399	8.884e-10	59.0	COG0533@1|root,COG0533@2|Bacteria,3Y2PN@57723|Acidobacteria,2JHJ0@204432|Acidobacteriia	204432|Acidobacteriia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TLS2_k127_6468845_1	1191523.MROS_0115	9.156e-128	423.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K03292,ko:K16248	-	-	-	-	ko00000,ko02000	2.A.2	-	-	MFS_2,MFS_3
TLS2_k127_6468845_0	1250005.PHEL85_0156	5.041e-196	621.0	COG2723@1|root,COG2723@2|Bacteria,4NEE2@976|Bacteroidetes,1HZG7@117743|Flavobacteriia	976|Bacteroidetes	G	Glycosyl hydrolase family 1	blgA	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
TLS2_k127_6478434_1	671143.DAMO_2963	1.173e-47	176.0	COG0224@1|root,COG0224@2|Bacteria,2NP76@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iLJ478.TM1611,iSSON_1240.SSON_3886,iYL1228.KPN_04138	ATP-synt
TLS2_k127_6478434_0	986075.CathTA2_2807	3.551e-232	730.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,4HAT6@91061|Bacilli	91061|Bacilli	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	iSB619.SA_RS10965	ATP-synt_ab,ATP-synt_ab_N
TLS2_k127_6478434_2	204669.Acid345_4331	2.84e-30	124.0	COG0355@1|root,COG0355@2|Bacteria,3Y515@57723|Acidobacteria,2JJJV@204432|Acidobacteriia	204432|Acidobacteriia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
TLS2_k127_6478434_3	797114.C475_07941	1.651e-11	66.0	COG0642@1|root,COG2203@1|root,COG3413@1|root,arCOG02278@2157|Archaea,arCOG02369@2157|Archaea,arCOG06192@2157|Archaea,2XW05@28890|Euryarchaeota,2410T@183963|Halobacteria	183963|Halobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	BAT,GAF_2,HTH_10,Response_reg
TLS2_k127_6480952_6	1128421.JAGA01000001_gene2075	2.935e-32	128.0	COG0205@1|root,COG0205@2|Bacteria,2NNY2@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfk-3	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
TLS2_k127_6480952_1	395961.Cyan7425_4232	1.79e-101	341.0	COG1611@1|root,COG1611@2|Bacteria,1G0JD@1117|Cyanobacteria,3KHGZ@43988|Cyanothece	1117|Cyanobacteria	S	PFAM conserved	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TLS2_k127_6480952_3	760568.Desku_2735	7.393e-77	269.0	COG1163@1|root,COG1163@2|Bacteria,1TSAP@1239|Firmicutes,24EEW@186801|Clostridia,260UT@186807|Peptococcaceae	186801|Clostridia	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
TLS2_k127_6480952_0	595460.RRSWK_04532	7.706e-196	616.0	COG0673@1|root,COG0673@2|Bacteria,2IXPT@203682|Planctomycetes	203682|Planctomycetes	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_6480952_4	573370.DMR_05470	4.365e-71	256.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1PFBF@1224|Proteobacteria,42RAR@68525|delta/epsilon subdivisions,2WN52@28221|Deltaproteobacteria,2M9X4@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,GAF_2,SpoIIE
TLS2_k127_6480952_2	945713.IALB_0353	5.388e-91	306.0	COG0101@1|root,COG0101@2|Bacteria	2|Bacteria	J	tRNA pseudouridine synthase activity	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
TLS2_k127_6480952_8	357808.RoseRS_1103	8.85e-12	77.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.243	ko:K16215	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
TLS2_k127_6480952_9	1120953.AUBH01000006_gene2578	9.366e-07	51.0	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,1S64W@1236|Gammaproteobacteria,467Z7@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	COG0526 Thiol-disulfide isomerase and thioredoxins	trxC	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
TLS2_k127_6480952_5	1168065.DOK_01329	1.238e-61	231.0	COG4872@1|root,COG4872@2|Bacteria,1NAIX@1224|Proteobacteria,1S1XV@1236|Gammaproteobacteria,1J9Q3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
TLS2_k127_6480952_7	1168065.DOK_01334	1.714e-30	130.0	COG4929@1|root,COG4929@2|Bacteria,1NURJ@1224|Proteobacteria,1T0ZP@1236|Gammaproteobacteria,1JAM3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	GDYXXLXY protein	-	-	-	-	-	-	-	-	-	-	-	-	GDYXXLXY
TLS2_k127_6512501_0	1340493.JNIF01000003_gene1928	8.542e-218	719.0	COG1629@1|root,COG1629@2|Bacteria,3Y2FQ@57723|Acidobacteria	57723|Acidobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_6512501_1	1128421.JAGA01000001_gene2098	3.387e-196	619.0	COG1063@1|root,COG1063@2|Bacteria,2NP68@2323|unclassified Bacteria	2|Bacteria	E	Zinc-binding dehydrogenase	fdh	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
TLS2_k127_6512501_2	1095769.CAHF01000005_gene1476	6.903e-91	310.0	COG5637@1|root,COG5637@2|Bacteria,1RHZP@1224|Proteobacteria,2WC63@28216|Betaproteobacteria,4771S@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TLS2_k127_6512501_5	1382359.JIAL01000001_gene1389	6.856e-10	66.0	COG0457@1|root,COG0457@2|Bacteria,3Y67U@57723|Acidobacteria	57723|Acidobacteria	O	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS2_k127_6512501_4	1121428.DESHY_20165___1	1.41e-10	71.0	28NT3@1|root,2ZBRV@2|Bacteria,1V1C2@1239|Firmicutes,257E3@186801|Clostridia	186801|Clostridia	S	YwiC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YwiC
TLS2_k127_6512501_3	1183438.GKIL_4354	1.143e-86	298.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_6526825_0	338966.Ppro_0968	2.572e-164	523.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,43TFC@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TLS2_k127_6526825_1	338966.Ppro_0967	7.855e-44	161.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,42TPZ@68525|delta/epsilon subdivisions,2WQ0P@28221|Deltaproteobacteria,43V8I@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
TLS2_k127_6535348_0	204669.Acid345_4155	1.298e-110	382.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria,2JIZ4@204432|Acidobacteriia	204432|Acidobacteriia	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS2_k127_6535348_1	391603.FBALC1_08893	1.055e-39	166.0	2ECHH@1|root,336FR@2|Bacteria,4P1IG@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6543129_1	234267.Acid_2734	1.914e-128	436.0	COG1629@1|root,COG4771@2|Bacteria,3Y2WI@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
TLS2_k127_6543129_3	1349822.NSB1T_04840	2.034e-53	196.0	COG0564@1|root,COG0564@2|Bacteria,4NHCT@976|Bacteroidetes,2FNNK@200643|Bacteroidia,22W6X@171551|Porphyromonadaceae	976|Bacteroidetes	J	Belongs to the pseudouridine synthase RluA family	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_6543129_5	522373.Smlt4170	8.229e-31	138.0	COG3428@1|root,COG3428@2|Bacteria,1R51P@1224|Proteobacteria,1RNVC@1236|Gammaproteobacteria,1XD0K@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial PH domain	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
TLS2_k127_6543129_6	935863.AWZR01000002_gene1104	4.511e-21	101.0	COG3402@1|root,COG3402@2|Bacteria,1N5YG@1224|Proteobacteria,1S52F@1236|Gammaproteobacteria,1X7JX@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial PH domain	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
TLS2_k127_6543129_2	404589.Anae109_0232	3.446e-128	425.0	2DDTE@1|root,2ZJ6F@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6543129_0	1121904.ARBP01000025_gene6118	4.363e-279	877.0	COG1874@1|root,COG1874@2|Bacteria,4NK6M@976|Bacteroidetes,47MV4@768503|Cytophagia	976|Bacteroidetes	G	Beta-galactosidase trimerisation domain	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42M
TLS2_k127_6543129_4	1121382.JQKG01000013_gene453	1.788e-38	148.0	COG3011@1|root,COG3011@2|Bacteria,1WMPZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
TLS2_k127_6543129_7	1340493.JNIF01000003_gene2543	0.0004679	46.0	COG1409@1|root,COG1409@2|Bacteria,3Y6AF@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS2_k127_655018_1	1379698.RBG1_1C00001G0520	2.799e-33	136.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	rsbU	-	3.1.3.3,4.6.1.1	ko:K01768,ko:K07315	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	CHASE2,GAF,GAF_2,HATPase_c_2,SpoIIE
TLS2_k127_655018_2	483219.LILAB_23325	2.627e-13	79.0	2BR3U@1|root,32K1T@2|Bacteria,1Q2KE@1224|Proteobacteria,433U9@68525|delta/epsilon subdivisions,2X3H0@28221|Deltaproteobacteria,2YW23@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_655018_0	1380394.JADL01000003_gene4748	4.667e-56	199.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2U99Y@28211|Alphaproteobacteria,2JSN1@204441|Rhodospirillales	204441|Rhodospirillales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
TLS2_k127_6554896_1	1121904.ARBP01000003_gene6571	1.702e-70	250.0	COG1820@1|root,COG1820@2|Bacteria,4NJ35@976|Bacteroidetes,47KJ5@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS2_k127_6554896_2	1295642.H839_09998	1.125e-40	162.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,4HCSI@91061|Bacilli,1WFPU@129337|Geobacillus	91061|Bacilli	K	helix_turn_helix isocitrate lyase regulation	kipR	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
TLS2_k127_6554896_0	234267.Acid_1509	1.202e-85	299.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6558496_3	1121904.ARBP01000011_gene1523	3.767e-09	59.0	COG4124@1|root,COG4124@2|Bacteria,4NIAN@976|Bacteroidetes,47MJ7@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolase family 26	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Big_5,CBM_35,Glyco_hydro_26
TLS2_k127_6558496_0	1121104.AQXH01000008_gene2418	1.806e-142	461.0	COG2159@1|root,COG2159@2|Bacteria,4NG9U@976|Bacteroidetes,1IWYY@117747|Sphingobacteriia	976|Bacteroidetes	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_6558496_2	251221.35210997	5.404e-108	359.0	COG1131@1|root,COG1131@2|Bacteria,1G0BQ@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_6558496_1	251221.35210998	3.63e-109	375.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6558496_4	7739.XP_002611711.1	1.414e-08	59.0	COG3119@1|root,KOG3867@2759|Eukaryota,38CRA@33154|Opisthokonta,3BGPB@33208|Metazoa,3CTVU@33213|Bilateria,48564@7711|Chordata	33208|Metazoa	P	iduronate-2-sulfatase activity	IDS	GO:0000323,GO:0003674,GO:0003824,GO:0004423,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005773,GO:0005775,GO:0006022,GO:0006026,GO:0006027,GO:0006029,GO:0006082,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008484,GO:0009056,GO:0009057,GO:0009100,GO:0009987,GO:0016787,GO:0016788,GO:0019538,GO:0030203,GO:0030204,GO:0030207,GO:0031974,GO:0043170,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044273,GO:0044281,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0050654,GO:0070013,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903510	3.1.6.13	ko:K01136	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00076,M00078	R07812,R07821	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
TLS2_k127_6559092_1	518766.Rmar_1740	8.548e-71	247.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,1FK20@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_6559092_2	1267535.KB906767_gene3675	1.22e-67	247.0	COG2222@1|root,COG2222@2|Bacteria	2|Bacteria	M	isomerase activity	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
TLS2_k127_6559092_0	1267535.KB906767_gene3674	6.436e-186	587.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	MA20_02630	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_6559092_3	1192034.CAP_6235	5.861e-50	205.0	COG0664@1|root,COG1413@1|root,COG3202@1|root,COG0664@2|Bacteria,COG1413@2|Bacteria,COG3202@2|Bacteria,1N61M@1224|Proteobacteria,42Y1U@68525|delta/epsilon subdivisions,2WNPK@28221|Deltaproteobacteria,2Z01S@29|Myxococcales	28221|Deltaproteobacteria	CT	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,TLC,cNMP_binding
TLS2_k127_6563468_1	472759.Nhal_3295	4.107e-98	337.0	COG1680@1|root,COG1680@2|Bacteria,1NPBV@1224|Proteobacteria,1SQWZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Domain of unknown function (DUF4185)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185
TLS2_k127_6563468_2	378806.STAUR_6990	3.788e-36	158.0	COG4412@1|root,COG4412@2|Bacteria,1R3SG@1224|Proteobacteria,42SZZ@68525|delta/epsilon subdivisions,2WPD0@28221|Deltaproteobacteria,2YUKS@29|Myxococcales	28221|Deltaproteobacteria	E	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M36,REJ
TLS2_k127_6563468_3	55952.BU52_16130	8.02e-08	66.0	COG4733@1|root,COG4733@2|Bacteria,2HCWC@201174|Actinobacteria	201174|Actinobacteria	Q	PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	Malectin,PA14
TLS2_k127_6563468_0	649638.Trad_0219	6.381e-109	356.0	COG3546@1|root,COG3546@2|Bacteria,1WI7Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Manganese containing catalase	-	-	-	-	-	-	-	-	-	-	-	-	Mn_catalase
TLS2_k127_6566299_1	1122962.AULH01000008_gene2169	1.078e-60	216.0	COG4154@1|root,COG4154@2|Bacteria,1RJ03@1224|Proteobacteria,2U9P9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the RbsD FucU family	fucU	GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0005996,GO:0006004,GO:0008150,GO:0008152,GO:0016853,GO:0016854,GO:0016857,GO:0019318,GO:0030246,GO:0036094,GO:0042806,GO:0044238,GO:0044281,GO:0048029,GO:0071704	5.1.3.29	ko:K02431	-	-	R10764	RC00563	ko00000,ko01000	-	-	-	RbsD_FucU
TLS2_k127_6566299_2	240015.ACP_0501	3.81e-41	161.0	COG2885@1|root,COG2885@2|Bacteria,3Y3ZY@57723|Acidobacteria,2JI9Y@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
TLS2_k127_6566299_0	880073.Calab_3116	1.403e-72	250.0	COG0693@1|root,COG0693@2|Bacteria,2NPFP@2323|unclassified Bacteria	2|Bacteria	S	DJ-1/PfpI family	pfpI	-	3.5.1.124	ko:K03152,ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
TLS2_k127_6566299_3	1227266.HMPREF1551_01653	1.368e-08	58.0	COG4122@1|root,COG4122@2|Bacteria,4NH42@976|Bacteroidetes,1HYQJ@117743|Flavobacteriia,1EQX4@1016|Capnocytophaga	976|Bacteroidetes	S	O-methyltransferase	mdmC	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
TLS2_k127_6573153_1	671143.DAMO_2381	1.096e-118	396.0	COG0719@1|root,COG0719@2|Bacteria,2NPGC@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufD	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840	-	ko:K07033,ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
TLS2_k127_6573153_2	472759.Nhal_0689	1.859e-118	385.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1WWC1@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM FeS assembly ATPase SufC	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
TLS2_k127_6573153_0	1382359.JIAL01000001_gene678	5.674e-265	820.0	COG0719@1|root,COG0719@2|Bacteria,3Y2IX@57723|Acidobacteria	57723|Acidobacteria	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TLS2_k127_6573153_4	472759.Nhal_0687	2.818e-36	144.0	COG1959@1|root,COG1959@2|Bacteria,1N0E2@1224|Proteobacteria,1S915@1236|Gammaproteobacteria,1X1A7@135613|Chromatiales	135613|Chromatiales	K	transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TLS2_k127_6573153_6	1111730.ATTM01000008_gene714	5.605e-24	104.0	2E3Q4@1|root,32YN3@2|Bacteria,4NVYD@976|Bacteroidetes,1IE48@117743|Flavobacteriia,2NZU2@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6573153_5	1340493.JNIF01000003_gene4251	2.583e-33	143.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	FHA,VWA,VWA_2
TLS2_k127_6573153_3	1379698.RBG1_1C00001G0370	1.738e-90	316.0	COG0616@1|root,COG0616@2|Bacteria,2NNKU@2323|unclassified Bacteria	2|Bacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TLS2_k127_6580493_1	472759.Nhal_1562	4.297e-10	70.0	COG0265@1|root,COG0265@2|Bacteria,1R6VW@1224|Proteobacteria,1SNEA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6580493_0	1118060.CAGZ01000032_gene1306	1.978e-64	230.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4CVC4@84998|Coriobacteriia	84998|Coriobacteriia	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_6589236_0	1242864.D187_003480	0.0	1033.0	COG1429@1|root,COG1429@2|Bacteria,1QX7D@1224|Proteobacteria,43C0E@68525|delta/epsilon subdivisions,2X7B3@28221|Deltaproteobacteria,2Z3EW@29|Myxococcales	28221|Deltaproteobacteria	H	Glycosyl hydrolase family 63 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
TLS2_k127_6589236_3	404589.Anae109_1555	4.361e-24	103.0	COG5660@1|root,COG5660@2|Bacteria,1NH4R@1224|Proteobacteria	1224|Proteobacteria	S	Transmembrane anti-sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_6589236_1	1382306.JNIM01000001_gene1690	1.762e-172	556.0	COG1249@1|root,COG1249@2|Bacteria,2G5VW@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	merA	-	1.16.1.1	ko:K00520	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_6589236_2	543728.Vapar_1657	9.957e-33	130.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,2VIKV@28216|Betaproteobacteria,4AESP@80864|Comamonadaceae	28216|Betaproteobacteria	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
TLS2_k127_6593930_4	1123242.JH636434_gene5340	1.572e-15	85.0	COG1413@1|root,COG1413@2|Bacteria,2IZE1@203682|Planctomycetes	203682|Planctomycetes	C	E-Z type HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
TLS2_k127_6593930_3	697281.Mahau_1193	1.206e-89	306.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,42FY5@68295|Thermoanaerobacterales	186801|Clostridia	K	Periplasmic binding protein LacI transcriptional regulator	-	-	5.1.1.1	ko:K01775,ko:K02529,ko:K05499	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_6593930_2	1089551.KE386572_gene299	3.083e-117	384.0	28TQ4@1|root,2ZFXE@2|Bacteria	2|Bacteria	S	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_6593930_0	575540.Isop_0569	7.763e-198	624.0	COG0673@1|root,COG0673@2|Bacteria,2IWTD@203682|Planctomycetes	203682|Planctomycetes	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_6593930_1	1434325.AZQN01000015_gene1376	7.757e-178	564.0	COG1482@1|root,COG1482@2|Bacteria,4NGGP@976|Bacteroidetes,47NZ6@768503|Cytophagia	976|Bacteroidetes	G	cell wall glycoprotein biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_659453_1	706434.HMPREF9429_01439	1.336e-37	147.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,4H2CM@909932|Negativicutes	909932|Negativicutes	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_N,zf-CHC2
TLS2_k127_659453_0	234267.Acid_7718	8.935e-118	407.0	COG1193@1|root,COG1193@2|Bacteria,3Y2Z2@57723|Acidobacteria	57723|Acidobacteria	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
TLS2_k127_659742_1	661478.OP10G_0097	1.916e-122	407.0	COG1252@1|root,COG1252@2|Bacteria	2|Bacteria	C	NADH dehydrogenase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_659742_2	525904.Tter_1202	4.447e-96	324.0	COG2896@1|root,COG2896@2|Bacteria,2NP5R@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0030312,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22,4.6.1.17	ko:K03639,ko:K20967	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394,R11372	RC03420,RC03425	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
TLS2_k127_659742_0	1382359.JIAL01000001_gene1831	6.527e-151	488.0	COG0379@1|root,COG0379@2|Bacteria,3Y328@57723|Acidobacteria,2JHY8@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
TLS2_k127_659742_6	926550.CLDAP_02300	2.879e-35	154.0	COG5617@1|root,COG5617@2|Bacteria,2G8CQ@200795|Chloroflexi	200795|Chloroflexi	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_659742_7	204669.Acid345_2361	1.625e-06	53.0	2ETRB@1|root,33M8W@2|Bacteria,3Y5ZS@57723|Acidobacteria,2JNW9@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF465)	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
TLS2_k127_659742_5	1121451.DESAM_21920	1.555e-45	173.0	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,42QDS@68525|delta/epsilon subdivisions,2WMQ3@28221|Deltaproteobacteria,2M7ZF@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
TLS2_k127_659742_4	637390.AFOH01000132_gene1862	6.43e-51	191.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,2NBXP@225057|Acidithiobacillales	225057|Acidithiobacillales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_659742_3	1232410.KI421418_gene2173	9.002e-56	202.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,43S0N@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Divalent cation transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
TLS2_k127_6606973_1	671143.DAMO_2996	7.005e-68	244.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
TLS2_k127_6606973_0	1254432.SCE1572_51570	8.717e-92	311.0	COG3568@1|root,COG3568@2|Bacteria,1PPNP@1224|Proteobacteria,42QW2@68525|delta/epsilon subdivisions,2WMRN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_6606973_2	1499967.BAYZ01000118_gene3301	1.202e-37	144.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	lsrG	-	5.3.1.32	ko:K11530	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	ABM
TLS2_k127_663547_5	240016.ABIZ01000001_gene5355	4.663e-32	136.0	COG0438@1|root,COG0438@2|Bacteria,46X9P@74201|Verrucomicrobia,2IV4I@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_663547_3	158190.SpiGrapes_2249	4.27e-45	180.0	COG0438@1|root,COG0438@2|Bacteria,2JAVP@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_663547_0	1229172.JQFA01000004_gene1731	1.345e-74	267.0	COG1134@1|root,COG1134@2|Bacteria,1G28R@1117|Cyanobacteria,1H8CS@1150|Oscillatoriales	1117|Cyanobacteria	GM	ABC-type polysaccharide polyol phosphate transport system ATPase component	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
TLS2_k127_663547_2	304371.MCP_1936	1.557e-53	198.0	COG1682@1|root,arCOG04339@2157|Archaea,2Y2VQ@28890|Euryarchaeota,2NA8H@224756|Methanomicrobia	224756|Methanomicrobia	P	ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
TLS2_k127_663547_4	1487953.JMKF01000007_gene5859	4.059e-39	159.0	COG1215@1|root,COG1215@2|Bacteria,1G8C4@1117|Cyanobacteria,1HHUN@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_663678_0	641524.ADICYQ_3837	3.721e-200	638.0	28MHM@1|root,2ZAUH@2|Bacteria,4NKMG@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_663678_4	868131.MSWAN_0335	0.0001702	53.0	COG3543@1|root,arCOG04456@2157|Archaea,2Y0PQ@28890|Euryarchaeota,23PTG@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF1284)	-	-	-	ko:K09706	-	-	-	-	ko00000	-	-	-	DUF1284
TLS2_k127_663678_2	926550.CLDAP_24220	9.989e-140	452.0	28JDC@1|root,2Z97R@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4432)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4432
TLS2_k127_663678_3	216595.PFLU_2996	2.295e-14	84.0	COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,1S69E@1236|Gammaproteobacteria,1YPM1@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	EG	Solute carrier family 35	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_663678_1	469383.Cwoe_5111	1.074e-142	467.0	COG0402@1|root,COG0402@2|Bacteria,2I9BJ@201174|Actinobacteria	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS2_k127_6648762_0	635013.TherJR_2071	2.767e-128	423.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,2602N@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS2_k127_6648762_1	330214.NIDE0964	2.358e-52	208.0	COG0642@1|root,COG2205@2|Bacteria	330214.NIDE0964|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6653838_0	518766.Rmar_0089	1.727e-104	350.0	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1FIP6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_6653838_1	1347342.BN863_12330	1.476e-88	303.0	COG0667@1|root,COG0667@2|Bacteria,4NF06@976|Bacteroidetes,1HZ2C@117743|Flavobacteriia	976|Bacteroidetes	C	Aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_6655872_2	1267535.KB906767_gene4686	7.356e-36	145.0	COG1305@1|root,COG1305@2|Bacteria,3Y3A2@57723|Acidobacteria	57723|Acidobacteria	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
TLS2_k127_6655872_1	1267535.KB906767_gene4685	1.636e-140	471.0	COG1305@1|root,COG1305@2|Bacteria,3Y2TK@57723|Acidobacteria,2JHX7@204432|Acidobacteriia	204432|Acidobacteriia	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
TLS2_k127_6655872_0	1168034.FH5T_19355	2.546e-145	480.0	COG1387@1|root,COG1387@2|Bacteria,4NMBC@976|Bacteroidetes,2FNU7@200643|Bacteroidia	976|Bacteroidetes	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_6667654_2	568816.Acin_1032	2.294e-46	174.0	COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,4H2TJ@909932|Negativicutes	909932|Negativicutes	S	PSP1 C-terminal domain protein	yaaT	-	-	-	-	-	-	-	-	-	-	-	PSP1
TLS2_k127_6667654_3	1499967.BAYZ01000056_gene4877	3.329e-42	168.0	COG2812@1|root,COG2812@2|Bacteria,2NPH0@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase III, delta subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
TLS2_k127_6667654_1	1121440.AUMA01000006_gene1505	4.225e-53	194.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,42RK3@68525|delta/epsilon subdivisions,2WNES@28221|Deltaproteobacteria,2M82V@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
TLS2_k127_6667654_0	868864.Dester_0534	5.39e-61	217.0	COG0325@1|root,COG0325@2|Bacteria,2G3XD@200783|Aquificae	200783|Aquificae	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
TLS2_k127_6667654_4	269799.Gmet_1164	2.242e-07	56.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,42VE5@68525|delta/epsilon subdivisions,2WR8T@28221|Deltaproteobacteria,43VHW@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	DUF167	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
TLS2_k127_6667656_1	1047013.AQSP01000095_gene2314	3.033e-83	282.0	COG0001@1|root,COG0001@2|Bacteria,2NNV5@2323|unclassified Bacteria	2|Bacteria	H	PFAM aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,NMO
TLS2_k127_6667656_2	234267.Acid_2025	2.958e-71	257.0	COG0544@1|root,COG0544@2|Bacteria,3Y45D@57723|Acidobacteria	57723|Acidobacteria	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
TLS2_k127_6667656_0	240015.ACP_3433	4.262e-100	328.0	COG0740@1|root,COG0740@2|Bacteria,3Y2SY@57723|Acidobacteria,2JHPB@204432|Acidobacteriia	204432|Acidobacteriia	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TLS2_k127_6667656_3	405948.SACE_1362	7.303e-39	149.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,4DYXZ@85010|Pseudonocardiales	201174|Actinobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
TLS2_k127_6672045_0	1191523.MROS_1588	2.128e-171	549.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	fucP	-	-	ko:K02429	-	-	-	-	ko00000,ko02000	2.A.1.7	-	-	MFS_1
TLS2_k127_6676537_1	880073.Calab_3285	4.4e-125	414.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
TLS2_k127_6676537_2	1267535.KB906767_gene1124	7.901e-05	46.0	COG0577@1|root,COG0577@2|Bacteria,3Y6YF@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_6676537_0	251221.35211765	6.552e-139	467.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_6681773_2	1499967.BAYZ01000017_gene6227	9.155e-94	327.0	COG4191@1|root,COG4191@2|Bacteria,2NP7Y@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HAMP,HATPase_c,HisKA
TLS2_k127_6681773_0	880073.Calab_0859	1.381e-115	390.0	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07714,ko:K19641	ko02020,map02020	M00500,M00772	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_6681773_3	861299.J421_0129	1.637e-73	263.0	COG1835@1|root,COG1835@2|Bacteria	2|Bacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS2_k127_6681773_4	330084.JNYZ01000013_gene5828	4.454e-30	126.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4DXS2@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigM	GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6681773_1	1340493.JNIF01000003_gene4548	6.964e-100	336.0	COG0482@1|root,COG0482@2|Bacteria,3Y2JX@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TLS2_k127_6684760_1	234267.Acid_0921	5.332e-241	758.0	COG3581@1|root,COG3581@2|Bacteria	2|Bacteria	I	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6684760_0	234267.Acid_0922	0.0	1592.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,3Y7VB@57723|Acidobacteria	57723|Acidobacteria	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
TLS2_k127_6684760_3	330214.NIDE1377	2.373e-08	60.0	COG1391@1|root,COG1391@2|Bacteria	2|Bacteria	H	[glutamate-ammonia-ligase] adenylyltransferase activity	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
TLS2_k127_6694939_3	91464.S7335_2692	3.298e-99	333.0	COG0438@1|root,COG0438@2|Bacteria,1GC4Q@1117|Cyanobacteria	1117|Cyanobacteria	H	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
TLS2_k127_6694939_7	489825.LYNGBM3L_05860	2.515e-72	256.0	COG4424@1|root,COG4424@2|Bacteria,1G29K@1117|Cyanobacteria,1HAQB@1150|Oscillatoriales	1117|Cyanobacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
TLS2_k127_6694939_4	1170562.Cal6303_2148	8.011e-96	327.0	COG0438@1|root,COG0438@2|Bacteria,1G2T9@1117|Cyanobacteria	1117|Cyanobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_6694939_6	1123226.KB899287_gene3636	5.368e-82	288.0	COG0438@1|root,COG0438@2|Bacteria,1TY3X@1239|Firmicutes,4I773@91061|Bacilli,26W57@186822|Paenibacillaceae	91061|Bacilli	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
TLS2_k127_6694939_2	880073.Calab_0443	6.903e-129	426.0	COG1115@1|root,COG1115@2|Bacteria,2NPBF@2323|unclassified Bacteria	2|Bacteria	U	Sodium:alanine symporter family	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
TLS2_k127_6694939_5	682795.AciX8_1155	8.297e-93	324.0	COG0745@1|root,COG0745@2|Bacteria,3Y2I8@57723|Acidobacteria,2JMD7@204432|Acidobacteriia	204432|Acidobacteriia	KT	Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	Malectin
TLS2_k127_6694939_0	1267535.KB906767_gene2230	0.0	1099.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_6694939_1	497964.CfE428DRAFT_0194	2.852e-266	832.0	COG4284@1|root,COG4284@2|Bacteria,46SCH@74201|Verrucomicrobia	74201|Verrucomicrobia	H	UTP--glucose-1-phosphate uridylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	UDPGP
TLS2_k127_6697793_0	518766.Rmar_2049	2.03e-264	840.0	COG1506@1|root,COG2706@1|root,COG1506@2|Bacteria,COG2706@2|Bacteria,4PIC9@976|Bacteroidetes,1FKAR@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6697793_1	639030.JHVA01000001_gene2812	1.45e-98	327.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU,PEMT
TLS2_k127_6714_5	313595.P700755_002631	6.787e-20	89.0	COG0332@1|root,COG0332@2|Bacteria,4NFIN@976|Bacteroidetes,1HY4I@117743|Flavobacteriia,4C3D5@83612|Psychroflexus	976|Bacteroidetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
TLS2_k127_6714_7	204669.Acid345_2265	7.909e-11	69.0	2EFJQ@1|root,339C1@2|Bacteria,3Y5HX@57723|Acidobacteria,2JK17@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6714_6	1340493.JNIF01000003_gene1428	3.634e-11	68.0	COG4980@1|root,COG4980@2|Bacteria,3Y5IA@57723|Acidobacteria	57723|Acidobacteria	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
TLS2_k127_6714_1	525904.Tter_0647	5.848e-80	274.0	COG0351@1|root,COG0351@2|Bacteria,2NP3M@2323|unclassified Bacteria	2|Bacteria	H	Phosphomethylpyrimidine kinase	thiD	GO:0008150,GO:0040007	2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7,4.1.99.17	ko:K00868,ko:K00941,ko:K03147,ko:K21219	ko00730,ko00750,ko01100,map00730,map00750,map01100	M00127	R00174,R01909,R02493,R03223,R03471,R03472,R04509,R10712	RC00002,RC00017,RC00224,RC03251,RC03252,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS03115	Phos_pyr_kin
TLS2_k127_6714_4	1188252.AJYK01000005_gene2998	7.54e-50	191.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RN5Z@1236|Gammaproteobacteria,1XT37@135623|Vibrionales	135623|Vibrionales	S	permease	VP2476	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_6714_2	1123242.JH636435_gene3106	1.183e-77	266.0	COG0177@1|root,COG0177@2|Bacteria,2IYYT@203682|Planctomycetes	203682|Planctomycetes	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
TLS2_k127_6714_3	373903.Hore_16050	5.958e-75	263.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,3WB29@53433|Halanaerobiales	186801|Clostridia	GK	TIGRFAM ROK family protein	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10220	ROK
TLS2_k127_6714_0	2423.NA23_0202400	1.634e-97	327.0	COG0297@1|root,COG0297@2|Bacteria,2GC9U@200918|Thermotogae	200918|Thermotogae	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	iLJ478.TM0895	Glyco_transf_5,Glycos_transf_1
TLS2_k127_6723690_1	401053.AciPR4_0767	7.509e-53	192.0	COG1187@1|root,COG1187@2|Bacteria,3Y3CQ@57723|Acidobacteria,2JHMG@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_6723690_3	234267.Acid_6490	1.909e-45	174.0	COG1386@1|root,COG1386@2|Bacteria,3Y3E0@57723|Acidobacteria	57723|Acidobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
TLS2_k127_6723690_2	289376.THEYE_A0360	3.479e-51	189.0	COG1354@1|root,COG1354@2|Bacteria,3J13J@40117|Nitrospirae	40117|Nitrospirae	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
TLS2_k127_6723690_0	1304875.JAFZ01000001_gene1674	6.623e-128	418.0	COG0180@1|root,COG0180@2|Bacteria,3TACD@508458|Synergistetes	508458|Synergistetes	J	TIGRFAM tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS2_k127_6723690_4	870187.Thini_0535	3.893e-22	100.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,460HE@72273|Thiotrichales	72273|Thiotrichales	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
TLS2_k127_6730438_4	748449.Halha_2093	1.178e-34	134.0	COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,24JBJ@186801|Clostridia,3WARJ@53433|Halanaerobiales	186801|Clostridia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
TLS2_k127_6730438_7	880073.Calab_3706	3.525e-15	77.0	COG0291@1|root,COG0291@2|Bacteria,2NQ3J@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
TLS2_k127_6730438_2	868595.Desca_1052	1.526e-56	203.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,260V8@186807|Peptococcaceae	186801|Clostridia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
TLS2_k127_6730438_0	1499967.BAYZ01000003_gene5878	9.61e-221	701.0	COG0441@1|root,COG0441@2|Bacteria,2NNMT@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
TLS2_k127_6730438_5	485918.Cpin_0888	5.795e-27	113.0	COG0776@1|root,COG0776@2|Bacteria,4NSK6@976|Bacteroidetes,1IYVW@117747|Sphingobacteriia	976|Bacteroidetes	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_6730438_1	204669.Acid345_4232	1.467e-71	261.0	COG0793@1|root,COG0793@2|Bacteria,3Y3A7@57723|Acidobacteria,2JHJK@204432|Acidobacteriia	204432|Acidobacteriia	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
TLS2_k127_6730438_6	1410612.JNKO01000002_gene2462	4.699e-19	91.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,2PSD9@265975|Oribacterium	186801|Clostridia	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
TLS2_k127_6730438_3	1267534.KB906758_gene2295	3.375e-50	189.0	COG1559@1|root,COG1559@2|Bacteria,3Y2RD@57723|Acidobacteria,2JIQ0@204432|Acidobacteriia	204432|Acidobacteriia	M	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
TLS2_k127_673387_4	929712.KI912613_gene3930	5.789e-70	250.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4CPCY@84995|Rubrobacteria	84995|Rubrobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TLS2_k127_673387_2	234267.Acid_2167	4.559e-104	352.0	COG0477@1|root,COG2814@2|Bacteria,3Y47I@57723|Acidobacteria	57723|Acidobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_673387_1	1121920.AUAU01000037_gene2735	2.011e-194	619.0	COG0119@1|root,COG0119@2|Bacteria,3Y2WT@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS2_k127_673387_0	1303518.CCALI_02739	1.611e-232	727.0	COG0065@1|root,COG0065@2|Bacteria	2|Bacteria	E	3-isopropylmalate dehydratase activity	leuC	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531,iSB619.SA_RS10700	Aconitase
TLS2_k127_673387_3	1120973.AQXL01000133_gene1794	4.505e-92	305.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,4HFTY@91061|Bacilli,27907@186823|Alicyclobacillaceae	91061|Bacilli	E	Aconitase C-terminal domain	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
TLS2_k127_6741750_1	886293.Sinac_7309	1.088e-08	68.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
TLS2_k127_6741750_0	880073.Calab_0920	3.415e-158	511.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_6744941_1	1047013.AQSP01000067_gene2201	6.942e-74	257.0	COG3379@1|root,COG3379@2|Bacteria,2NQIG@2323|unclassified Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_6744941_8	1047013.AQSP01000067_gene2202	4.961e-19	87.0	2EQW9@1|root,33IG2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6744941_5	1047013.AQSP01000067_gene2203	3.554e-38	154.0	2DZX2@1|root,32VM6@2|Bacteria,2NRAT@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6744941_3	1499967.BAYZ01000008_gene5415	3.019e-55	199.0	COG3551@1|root,COG3551@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_trans_1_4,Glycos_transf_2,TPR_19
TLS2_k127_6744941_0	247490.KSU1_D0867	1.909e-104	360.0	COG2203@1|root,COG3829@1|root,COG4251@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,2J2DQ@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,dCache_1
TLS2_k127_6744941_2	1242864.D187_002317	2.752e-60	211.0	COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,42VIG@68525|delta/epsilon subdivisions,2WS98@28221|Deltaproteobacteria,2YV93@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_6744941_6	118173.KB235914_gene1177	7.141e-32	139.0	COG2203@1|root,COG5000@1|root,COG2203@2|Bacteria,COG5000@2|Bacteria,1GPZW@1117|Cyanobacteria,1HHT6@1150|Oscillatoriales	1117|Cyanobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_6744941_4	1396141.BATP01000016_gene2778	1.197e-47	186.0	COG0642@1|root,COG2203@1|root,COG4191@1|root,COG4585@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K13040	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HATPase_c_2,HisKA,HisKA_2,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_6744941_7	1502851.FG93_01290	4.441e-29	119.0	COG4274@1|root,COG4274@2|Bacteria,1N29P@1224|Proteobacteria,2UA3M@28211|Alphaproteobacteria,3K0TJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
TLS2_k127_6744941_9	742723.HMPREF9477_01753	2.332e-09	61.0	COG5434@1|root,COG5434@2|Bacteria,1UI0G@1239|Firmicutes,25B1F@186801|Clostridia	186801|Clostridia	M	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,F5_F8_type_C,FIVAR
TLS2_k127_6745743_1	262724.TT_C0657	1.25e-11	68.0	COG1846@1|root,COG1846@2|Bacteria,1WJ5A@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6745743_0	266117.Rxyl_1917	1.028e-60	226.0	COG0358@1|root,COG1846@1|root,COG0358@2|Bacteria,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	2.1.1.303	ko:K02316,ko:K04096,ko:K20421	ko01059,ko01130,ko03030,map01059,map01130,map03030	M00830	R10963	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_processg_A,DnaB_C,Methyltransf_2,Toprim_2,Toprim_3,zf-CHC2
TLS2_k127_6745743_2	66874.JOFS01000008_gene2416	0.0009642	46.0	COG3311@1|root,COG3311@2|Bacteria	2|Bacteria	K	DNA excision	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
TLS2_k127_6755227_1	1047013.AQSP01000125_gene2632	1.367e-176	568.0	COG0591@1|root,COG0591@2|Bacteria,2NR0M@2323|unclassified Bacteria	2|Bacteria	E	Sodium:solute symporter family	yidK	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_6755227_0	926549.KI421517_gene2980	5.664e-253	804.0	COG2120@1|root,COG2120@2|Bacteria,4NE9K@976|Bacteroidetes,47KXK@768503|Cytophagia	976|Bacteroidetes	G	PFAM GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_6755227_3	1123487.KB892864_gene2089	6.911e-57	213.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2VIZR@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	1.5.1.21	ko:K13609	ko00310,ko00960,ko01100,map00310,map00960,map01100	-	R02203	RC00135	ko00000,ko00001,ko01000	-	-	-	Ldh_2
TLS2_k127_6755227_4	5911.EAR82286	1.663e-11	75.0	COG3914@1|root,KOG4308@1|root,KOG4308@2759|Eukaryota,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
TLS2_k127_6755227_2	696281.Desru_2540	7.222e-59	215.0	COG2267@1|root,COG2267@2|Bacteria,1V03N@1239|Firmicutes,25AKV@186801|Clostridia,2653R@186807|Peptococcaceae	186801|Clostridia	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6762743_1	335543.Sfum_0520	1.465e-90	304.0	COG1878@1|root,COG1878@2|Bacteria,1P8U5@1224|Proteobacteria,42SY1@68525|delta/epsilon subdivisions,2WPQ7@28221|Deltaproteobacteria,2MSBX@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Putative cyclase	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
TLS2_k127_6762743_2	1131730.BAVI_16857	1.069e-79	283.0	COG2159@1|root,COG2159@2|Bacteria,1UZI6@1239|Firmicutes	1239|Firmicutes	G	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_6762743_0	344747.PM8797T_05420	2.874e-255	795.0	COG3391@1|root,COG3391@2|Bacteria,2IY6R@203682|Planctomycetes	203682|Planctomycetes	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6764263_1	592029.DDD_1505	2.529e-36	160.0	COG1413@1|root,COG3202@1|root,COG1413@2|Bacteria,COG3202@2|Bacteria,4NIB2@976|Bacteroidetes,1HWNK@117743|Flavobacteriia,3HK2B@363408|Nonlabens	976|Bacteroidetes	C	TLC ATP/ADP transporter	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	TLC,cNMP_binding
TLS2_k127_6764263_0	706587.Desti_1267	1.89e-38	149.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2MQAG@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
TLS2_k127_676588_0	693661.Arcve_1538	1.396e-269	847.0	COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,245PG@183980|Archaeoglobi	183980|Archaeoglobi	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS2_k127_676588_1	338966.Ppro_0501	3.451e-121	404.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,42N3K@68525|delta/epsilon subdivisions,2WIMV@28221|Deltaproteobacteria,43SUA@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
TLS2_k127_676588_2	1356854.N007_01190	6.092e-95	321.0	COG0391@1|root,COG0391@2|Bacteria,1TPNV@1239|Firmicutes,4HA0Z@91061|Bacilli,2782E@186823|Alicyclobacillaceae	91061|Bacilli	S	Required for morphogenesis under gluconeogenic growth conditions	yvcK	-	-	-	-	-	-	-	-	-	-	-	UPF0052
TLS2_k127_6769805_1	583355.Caka_0705	2.979e-165	528.0	COG0673@1|root,COG0673@2|Bacteria,46U95@74201|Verrucomicrobia,3K969@414999|Opitutae	414999|Opitutae	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_6769805_0	1267535.KB906767_gene1639	5.673e-173	586.0	COG4775@1|root,COG4775@2|Bacteria,3Y9FK@57723|Acidobacteria	57723|Acidobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6769805_2	324057.Pjdr2_2995	2.644e-104	358.0	COG3250@1|root,COG3250@2|Bacteria,1TRMX@1239|Firmicutes,4IPVC@91061|Bacilli,2764N@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TLS2_k127_6772959_0	1121920.AUAU01000026_gene1443	8.861e-158	524.0	COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molydop_binding
TLS2_k127_6789357_2	290397.Adeh_2766	1.653e-25	106.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS2_k127_6789357_0	880073.Calab_1578	7.239e-207	659.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	MdlB	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_6789357_1	204669.Acid345_1514	1.012e-180	584.0	COG1132@1|root,COG1132@2|Bacteria,3Y32T@57723|Acidobacteria,2JIBZ@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter, transmembrane	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
TLS2_k127_6789357_3	1236542.BALM01000004_gene2455	6.493e-18	83.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,2QAJJ@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901564	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
TLS2_k127_6789669_0	589924.Ferp_2541	3.618e-62	222.0	COG0330@1|root,arCOG01915@2157|Archaea,2XTA2@28890|Euryarchaeota,2462J@183980|Archaeoglobi	183980|Archaeoglobi	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_6817969_2	591001.Acfer_1516	1.007e-26	110.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,4H4RQ@909932|Negativicutes	909932|Negativicutes	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
TLS2_k127_6817969_0	1047013.AQSP01000133_gene2117	1.079e-141	464.0	COG1757@1|root,COG1757@2|Bacteria,2NPD8@2323|unclassified Bacteria	2|Bacteria	C	Na+/H+ antiporter family	mleN	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
TLS2_k127_6817969_3	667014.Thein_0881	4.747e-08	65.0	COG0760@1|root,COG0760@2|Bacteria,2GHR3@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
TLS2_k127_6817969_1	1267535.KB906767_gene3597	9.056e-36	151.0	COG4775@1|root,COG4775@2|Bacteria,3Y2RF@57723|Acidobacteria,2JHK5@204432|Acidobacteriia	204432|Acidobacteriia	M	surface antigen variable number	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
TLS2_k127_6825476_4	240015.ACP_3129	7.759e-54	196.0	COG0223@1|root,COG0223@2|Bacteria,3Y32C@57723|Acidobacteria,2JHUK@204432|Acidobacteriia	204432|Acidobacteriia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TLS2_k127_6825476_3	1382359.JIAL01000001_gene476	1.652e-58	210.0	COG0242@1|root,COG0242@2|Bacteria,3Y4HY@57723|Acidobacteria,2JJ9D@204432|Acidobacteriia	204432|Acidobacteriia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TLS2_k127_6825476_0	234267.Acid_2745	5.608e-131	428.0	COG0082@1|root,COG0082@2|Bacteria,3Y2Z8@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
TLS2_k127_6825476_1	240015.ACP_0179	3.65e-84	287.0	COG0767@1|root,COG0767@2|Bacteria,3Y43S@57723|Acidobacteria,2JI8E@204432|Acidobacteriia	204432|Acidobacteriia	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
TLS2_k127_6825476_2	204669.Acid345_2891	6.024e-68	242.0	COG1127@1|root,COG1127@2|Bacteria,3Y3YI@57723|Acidobacteria,2JIF1@204432|Acidobacteriia	204432|Acidobacteriia	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TLS2_k127_6825476_5	240015.ACP_2954	4.525e-08	64.0	COG1463@1|root,COG1463@2|Bacteria,3Y3SX@57723|Acidobacteria,2JIP6@204432|Acidobacteriia	204432|Acidobacteriia	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
TLS2_k127_6828696_3	378806.STAUR_4816	1.316e-19	98.0	COG0745@1|root,COG0745@2|Bacteria,1N1N5@1224|Proteobacteria,42UP1@68525|delta/epsilon subdivisions,2WQAF@28221|Deltaproteobacteria,2YVKX@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_6828696_0	667014.Thein_0907	0.0	1023.0	COG0525@1|root,COG0525@2|Bacteria,2GGVS@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TLS2_k127_6828696_2	269799.Gmet_1988	3.698e-77	267.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,42MY7@68525|delta/epsilon subdivisions,2WJH7@28221|Deltaproteobacteria,43T21@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1988	QRPTase_C,QRPTase_N
TLS2_k127_6828696_1	234267.Acid_4221	4.002e-98	330.0	COG0552@1|root,COG0552@2|Bacteria,3Y3JQ@57723|Acidobacteria	57723|Acidobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
TLS2_k127_6834360_0	1396141.BATP01000042_gene1907	1.749e-45	171.0	COG3391@1|root,COG3391@2|Bacteria,46WEM@74201|Verrucomicrobia	74201|Verrucomicrobia	S	56kDa selenium binding protein (SBP56)	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
TLS2_k127_6834716_0	671143.DAMO_1946	1.731e-121	416.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PKD,SBBP
TLS2_k127_6834716_1	1110697.NCAST_26_00780	0.0003982	46.0	2B5NQ@1|root,31YI3@2|Bacteria,2GPRB@201174|Actinobacteria,4G0KR@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4188)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4188
TLS2_k127_6845303_2	338966.Ppro_3252	1.517e-60	220.0	COG0745@1|root,COG0745@2|Bacteria,1NVRN@1224|Proteobacteria,4309X@68525|delta/epsilon subdivisions,2WV75@28221|Deltaproteobacteria,43V34@69541|Desulfuromonadales	28221|Deltaproteobacteria	KT	RESPONSE REGULATOR receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6845303_1	243231.GSU1342	6.498e-87	296.0	COG0583@1|root,COG0583@2|Bacteria,1MXRP@1224|Proteobacteria,4302B@68525|delta/epsilon subdivisions,2WV7E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_6845303_0	243231.GSU1343	6.927e-116	376.0	COG1335@1|root,COG1335@2|Bacteria,1MU5N@1224|Proteobacteria,42Q9J@68525|delta/epsilon subdivisions,2WKMC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS2_k127_6896048_1	483219.LILAB_29895	7.829e-49	181.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TLS2_k127_6896048_0	204669.Acid345_0064	1.464e-179	570.0	COG0465@1|root,COG0465@2|Bacteria,3Y2UK@57723|Acidobacteria,2JI9D@204432|Acidobacteriia	204432|Acidobacteriia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TLS2_k127_6907287_3	1131269.AQVV01000032_gene310	2.763e-08	65.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	ko:K20306	-	-	-	-	ko00000,ko04131	-	-	-	Lipase_GDSL,Lipase_GDSL_2
TLS2_k127_6907287_1	870187.Thini_3469	8.995e-100	336.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
TLS2_k127_6907287_2	945713.IALB_2722	2.824e-15	77.0	2EGPU@1|root,33AFZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6907287_0	234267.Acid_0384	7.116e-135	448.0	COG0608@1|root,COG0608@2|Bacteria,3Y3HI@57723|Acidobacteria	57723|Acidobacteria	L	single-stranded-DNA-specific exonuclease RecJ	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TLS2_k127_6910047_0	1340493.JNIF01000003_gene3565	2.655e-79	296.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6932799_4	234267.Acid_5990	3.932e-111	368.0	COG1131@1|root,COG1131@2|Bacteria,3Y3VU@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6932799_2	234267.Acid_5991	6.712e-135	439.0	COG0842@1|root,COG0842@2|Bacteria,3Y4H7@57723|Acidobacteria	57723|Acidobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_6932799_0	234267.Acid_5992	1.42e-147	478.0	COG0842@1|root,COG0842@2|Bacteria,3Y73W@57723|Acidobacteria	57723|Acidobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_6932799_1	521674.Plim_2636	1.453e-144	477.0	COG3250@1|root,COG3250@2|Bacteria,2J54D@203682|Planctomycetes	203682|Planctomycetes	G	Pfam:DUF303	-	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	SASA
TLS2_k127_6932799_3	1237149.C900_03836	4.04e-126	420.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	putP_2	-	-	ko:K03307,ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21,2.A.21.2	-	-	SSF
TLS2_k127_6932799_5	1173024.KI912149_gene5641	6.019e-88	295.0	COG1225@1|root,COG1225@2|Bacteria,1G0JC@1117|Cyanobacteria,1JHTI@1189|Stigonemataceae	1117|Cyanobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_6932799_6	1408473.JHXO01000009_gene3488	1.229e-76	264.0	COG0667@1|root,COG0667@2|Bacteria,4P42C@976|Bacteroidetes	976|Bacteroidetes	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_6941560_3	240015.ACP_3278	1.744e-05	53.0	COG1629@1|root,COG1629@2|Bacteria,3Y66W@57723|Acidobacteria,2JKRP@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_6941560_2	102125.Xen7305DRAFT_00012030	4.029e-13	82.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,3VJQ2@52604|Pleurocapsales	1117|Cyanobacteria	O	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2,TPR_1,TPR_11,TPR_14,TPR_16,TPR_2,TPR_6,TPR_8
TLS2_k127_6941560_4	571166.KI421509_gene3338	3.114e-05	56.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	COG0457 FOG TPR repeat	MA20_42300	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
TLS2_k127_6941560_0	234267.Acid_7590	2.802e-160	524.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_7590|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6941560_1	530564.Psta_4263	2.995e-38	161.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	psrP1	-	-	-	-	-	-	-	-	-	-	-	CBM_6,CHU_C,GSDH,Malectin
TLS2_k127_6941560_5	1340493.JNIF01000004_gene110	0.0004217	42.0	COG3137@1|root,COG3137@2|Bacteria	2|Bacteria	-	-	ydiY	-	-	ko:K07283	-	-	-	-	ko00000	-	-	-	DUF3078,DUF481
TLS2_k127_6956608_2	999419.HMPREF1077_01288	1.509e-09	59.0	COG3534@1|root,COG3534@2|Bacteria,4NECK@976|Bacteroidetes,2FNNB@200643|Bacteroidia,22WR1@171551|Porphyromonadaceae	976|Bacteroidetes	G	Alpha-L-arabinofuranosidase C-terminus	abf2	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
TLS2_k127_6956608_1	1089553.Tph_c06350	2.303e-15	85.0	COG1740@1|root,COG1740@2|Bacteria,1TZZD@1239|Firmicutes,2489B@186801|Clostridia,42FSN@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM hydrogenase (NiFe) small subunit (hydA)	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
TLS2_k127_6956608_0	278957.ABEA03000041_gene2046	7.094e-74	258.0	COG3250@1|root,COG3250@2|Bacteria,46YAN@74201|Verrucomicrobia,3K989@414999|Opitutae	414999|Opitutae	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6962635_0	595460.RRSWK_04160	6.598e-19	89.0	COG0500@1|root,COG2226@2|Bacteria,2IYWE@203682|Planctomycetes	203682|Planctomycetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS2_k127_6976788_3	234267.Acid_2701	1.254e-16	89.0	COG2823@1|root,COG2823@2|Bacteria,3Y3MJ@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS2_k127_6976788_2	1340493.JNIF01000003_gene1452	2.885e-29	125.0	COG2948@1|root,COG2948@2|Bacteria,3Y81Q@57723|Acidobacteria	57723|Acidobacteria	U	multi-organism process	-	-	-	ko:K03195	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbI
TLS2_k127_6976788_0	1121033.AUCF01000001_gene1957	5.711e-140	462.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2TR0F@28211|Alphaproteobacteria,2JPYH@204441|Rhodospirillales	204441|Rhodospirillales	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
TLS2_k127_6976788_1	648996.Theam_0227	7.376e-107	358.0	COG0075@1|root,COG0075@2|Bacteria,2G3RP@200783|Aquificae	200783|Aquificae	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_6983800_2	1123354.AUDR01000013_gene604	2.407e-12	74.0	COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,2VTYZ@28216|Betaproteobacteria,1KRUM@119069|Hydrogenophilales	119069|Hydrogenophilales	S	RecX family	-	-	-	-	-	-	-	-	-	-	-	-	RecX
TLS2_k127_6983800_0	204669.Acid345_0704	2.815e-129	423.0	COG2805@1|root,COG2805@2|Bacteria,3Y316@57723|Acidobacteria,2JIT4@204432|Acidobacteriia	204432|Acidobacteriia	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TLS2_k127_6983800_1	1267535.KB906767_gene248	1.316e-108	356.0	COG0115@1|root,COG0115@2|Bacteria,3Y32X@57723|Acidobacteria,2JI58@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS2_k127_6992268_3	926550.CLDAP_25010	1.074e-150	484.0	COG0365@1|root,COG0365@2|Bacteria,2G830@200795|Chloroflexi	200795|Chloroflexi	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_6992268_4	1128421.JAGA01000002_gene634	3.213e-138	449.0	COG3185@1|root,COG3185@2|Bacteria	2|Bacteria	E	4-Hydroxyphenylpyruvate dioxygenase	hpd	GO:0003674,GO:0003824,GO:0003868,GO:0006082,GO:0006520,GO:0006570,GO:0006572,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0051213,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.27,1.13.11.46	ko:K00457,ko:K16421	ko00130,ko00261,ko00350,ko00360,ko01055,ko01100,ko01130,map00130,map00261,map00350,map00360,map01055,map01100,map01130	M00044	R01372,R02521,R06632	RC00505,RC00738,RC01471	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
TLS2_k127_6992268_1	1128421.JAGA01000002_gene632	1.76e-175	561.0	COG3508@1|root,COG3508@2|Bacteria,2NPWM@2323|unclassified Bacteria	2|Bacteria	Q	homogentisate 1,2-dioxygenase	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
TLS2_k127_6992268_5	1089550.ATTH01000001_gene1856	7.108e-63	232.0	COG0124@1|root,COG0124@2|Bacteria,4PEY8@976|Bacteroidetes,1FJUN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	histidyl-tRNA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6992268_0	1118054.CAGW01000053_gene1386	6.231e-179	570.0	COG0179@1|root,COG0179@2|Bacteria,1VRIW@1239|Firmicutes,4HUFK@91061|Bacilli,26U89@186822|Paenibacillaceae	91061|Bacilli	Q	Fumarylacetoacetase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase,FAA_hydrolase_N
TLS2_k127_6992268_9	204669.Acid345_3577	5.35e-19	97.0	29UCR@1|root,30FP6@2|Bacteria,3Y4J8@57723|Acidobacteria,2JMRB@204432|Acidobacteriia	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6992268_8	1304885.AUEY01000037_gene2189	1.367e-27	124.0	COG3829@1|root,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	3.1.3.3	ko:K07315,ko:K17763	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GGDEF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,STAS
TLS2_k127_6992268_6	545695.TREAZ_2314	4.61e-55	205.0	COG0637@1|root,COG0637@2|Bacteria,2J814@203691|Spirochaetes	203691|Spirochaetes	F	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	HAD_2,dCMP_cyt_deam_1
TLS2_k127_6992268_10	518766.Rmar_0344	8.851e-15	89.0	COG3292@1|root,COG3292@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
TLS2_k127_6992268_2	518766.Rmar_0343	4.082e-154	527.0	COG0840@1|root,COG3292@1|root,COG0840@2|Bacteria,COG3292@2|Bacteria,4NK8Q@976|Bacteroidetes	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GerE,HATPase_c,Reg_prop,SpoIIE,Y_Y_Y
TLS2_k127_6992268_7	909663.KI867151_gene3159	1.418e-40	174.0	COG2202@1|root,COG4191@1|root,COG4585@1|root,COG5001@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4585@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	2.7.7.65	ko:K21084	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000	-	-	-	CHASE,GAF,GAF_2,GGDEF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,SBP_bac_3,dCache_1
TLS2_k127_6993915_0	1047013.AQSP01000133_gene2141	2.356e-169	552.0	COG2605@1|root,COG2605@2|Bacteria	2|Bacteria	G	GHMP kinase	fkp	-	2.7.1.52	ko:K05305	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R03161	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Fucokinase,GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_6993915_1	143224.JQMD01000002_gene3708	1.02e-29	125.0	COG1082@1|root,COG1082@2|Bacteria,4NIWS@976|Bacteroidetes,1I5YW@117743|Flavobacteriia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS2_k127_6994455_6	1071679.BG57_06865	0.0003561	48.0	COG4627@1|root,COG4627@2|Bacteria,1N56P@1224|Proteobacteria,2VV7A@28216|Betaproteobacteria,1KHC7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
TLS2_k127_6994455_5	1192034.CAP_0777	2.293e-30	132.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.81	ko:K01219	-	-	-	-	ko00000,ko01000	-	-	-	Cellulase,Dockerin_1,Glyco_hydro_2_C
TLS2_k127_6994455_0	204669.Acid345_3907	5.334e-127	421.0	COG3667@1|root,COG3667@2|Bacteria,3Y3FP@57723|Acidobacteria,2JITP@204432|Acidobacteriia	204432|Acidobacteriia	P	copper resistance	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6994455_3	247490.KSU1_D0035	8.63e-54	198.0	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_6994455_1	1232410.KI421414_gene2918	1.49e-70	255.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,42N2B@68525|delta/epsilon subdivisions,2WJS9@28221|Deltaproteobacteria,43SK4@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
TLS2_k127_6994455_4	240016.ABIZ01000001_gene732	1.395e-39	158.0	COG1387@1|root,COG1387@2|Bacteria,46SMB@74201|Verrucomicrobia,2IU6X@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	PHP domain	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
TLS2_k127_6994455_2	234267.Acid_0540	3.406e-68	241.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
TLS2_k127_6998620_0	313612.L8106_02152	2.481e-121	400.0	COG2755@1|root,COG2755@2|Bacteria,1G2XP@1117|Cyanobacteria,1H81W@1150|Oscillatoriales	1117|Cyanobacteria	E	SGNH hydrolase-like domain, acetyltransferase AlgX	-	-	-	-	-	-	-	-	-	-	-	-	ALGX
TLS2_k127_6998620_1	351160.RCIX322	6.84e-63	228.0	COG0428@1|root,arCOG00576@2157|Archaea,2XX28@28890|Euryarchaeota,2NAV5@224756|Methanomicrobia	224756|Methanomicrobia	P	divalent heavy-metal cations transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	-
TLS2_k127_6998620_2	1304275.C41B8_11810	8.645e-24	104.0	COG1670@1|root,COG1670@2|Bacteria,1MVG4@1224|Proteobacteria,1RQPX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins	rimJ	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS2_k127_6999221_2	868595.Desca_0020	1.479e-55	200.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,260VV@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TLS2_k127_6999221_1	234267.Acid_1043	5.796e-112	370.0	COG1210@1|root,COG1210@2|Bacteria,3Y39W@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Nucleotidyl transferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_6999221_0	1396418.BATQ01000181_gene833	4.767e-185	592.0	COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,46T85@74201|Verrucomicrobia	74201|Verrucomicrobia	OU	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PD40,PDZ_2,Peptidase_M28
TLS2_k127_700471_1	471853.Bcav_3800	4.725e-08	64.0	COG1680@1|root,COG2207@1|root,COG1680@2|Bacteria,COG2207@2|Bacteria,2HXSV@201174|Actinobacteria	201174|Actinobacteria	KV	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185
TLS2_k127_700471_0	1380391.JIAS01000005_gene2396	4.709e-129	432.0	COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,2U2CB@28211|Alphaproteobacteria,2JXAQ@204441|Rhodospirillales	204441|Rhodospirillales	G	Glycosyl hydrolases family 2, sugar binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glyco_hydro_2_N
TLS2_k127_7005206_0	118173.KB235910_gene4601	9.063e-194	614.0	COG0017@1|root,COG0017@2|Bacteria,1G015@1117|Cyanobacteria,1H7PZ@1150|Oscillatoriales	1117|Cyanobacteria	J	PFAM tRNA synthetases class II (D, K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
TLS2_k127_7005206_1	234267.Acid_2806	2.668e-106	349.0	COG1082@1|root,COG1082@2|Bacteria,3Y4EN@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_7013142_2	240015.ACP_0977	1.695e-62	218.0	COG2256@1|root,COG2256@2|Bacteria,3Y3F7@57723|Acidobacteria,2JIAH@204432|Acidobacteriia	204432|Acidobacteriia	L	AAA ATPase	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
TLS2_k127_7013142_1	309807.SRU_1748	1.35e-72	265.0	COG2027@1|root,COG2027@2|Bacteria,4NGIQ@976|Bacteroidetes,1FIVK@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	D-Ala-D-Ala carboxypeptidase 3 (S13) family	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
TLS2_k127_7013142_0	344747.PM8797T_07534	3.145e-150	480.0	COG1073@1|root,COG1073@2|Bacteria,2IWT8@203682|Planctomycetes	203682|Planctomycetes	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_701452_0	1121413.JMKT01000017_gene426	0.0	1099.0	COG1615@1|root,COG1615@2|Bacteria,1MZ5A@1224|Proteobacteria,42M4M@68525|delta/epsilon subdivisions,2WIPI@28221|Deltaproteobacteria,2MEAF@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
TLS2_k127_701452_3	1166948.JPZL01000004_gene50	3.892e-38	164.0	COG4585@1|root,COG5002@1|root,COG4585@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HWE_HK,HisKA_3,PAS_4
TLS2_k127_701452_1	1128421.JAGA01000003_gene3260	9.47e-41	172.0	COG5001@1|root,COG5001@2|Bacteria,2NP1A@2323|unclassified Bacteria	2|Bacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	CheB_methylest,CheR,CheR_N,EAL,GGDEF,PAS,PAS_10,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_701452_4	760192.Halhy_5492	7.853e-09	67.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,Beta-lactamase
TLS2_k127_701452_2	1047013.AQSP01000130_gene1862	8.534e-39	150.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2NNS9@2323|unclassified Bacteria	2|Bacteria	EU	peptidase S9 prolyl oligopeptidase active site	ptpA_1	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008239,GO:0009056,GO:0009987,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042597,GO:0042802,GO:0042803,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044464,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_7015876_4	411459.RUMOBE_02663	6.868e-07	51.0	COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,3XZ8H@572511|Blautia	186801|Clostridia	H	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
TLS2_k127_7015876_3	1340493.JNIF01000003_gene2471	2.22e-12	70.0	2EE2F@1|root,337X5@2|Bacteria,3Y5GQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7015876_2	3218.PP1S568_5V6.1	1.122e-17	93.0	28N8S@1|root,2QUU3@2759|Eukaryota,37PDV@33090|Viridiplantae,3GEI2@35493|Streptophyta	35493|Streptophyta	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_7015876_0	1267535.KB906767_gene3077	6.915e-107	351.0	COG1136@1|root,COG1136@2|Bacteria,3Y30Q@57723|Acidobacteria,2JI7R@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_7015876_1	204669.Acid345_3323	1.015e-87	307.0	COG0845@1|root,COG0845@2|Bacteria,3Y2XR@57723|Acidobacteria,2JHTV@204432|Acidobacteriia	204432|Acidobacteriia	M	Efflux transporter, RND family, MFP subunit	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
TLS2_k127_7023612_1	41431.PCC8801_0111	3.138e-35	146.0	COG1807@1|root,COG1807@2|Bacteria,1GBC1@1117|Cyanobacteria	1117|Cyanobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7023612_0	1267535.KB906767_gene5108	2.226e-103	352.0	COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria,2JITF@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TLS2_k127_7033582_1	517418.Ctha_0793	4.311e-58	205.0	COG0381@1|root,COG0381@2|Bacteria,1FDZG@1090|Chlorobi	1090|Chlorobi	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
TLS2_k127_7033582_0	526222.Desal_3470	1.072e-115	396.0	COG5360@1|root,COG5360@2|Bacteria,1MZ5X@1224|Proteobacteria,42PG1@68525|delta/epsilon subdivisions,2WP6V@28221|Deltaproteobacteria,2MAC3@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Heparinase II/III N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III,Hepar_II_III_N
TLS2_k127_7033582_2	172088.AUGA01000026_gene335	3.572e-27	117.0	COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,1PS9M@1224|Proteobacteria,2V4GN@28211|Alphaproteobacteria,3JWNE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,GFO_IDH_MocA
TLS2_k127_705429_2	234267.Acid_4250	4.992e-41	164.0	COG0644@1|root,COG0644@2|Bacteria,3Y5JJ@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Pyr_redox_2
TLS2_k127_705429_1	1267535.KB906767_gene1016	1.388e-77	270.0	COG3391@1|root,COG3391@2|Bacteria,3Y99Z@57723|Acidobacteria,2JP6W@204432|Acidobacteriia	204432|Acidobacteriia	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_705429_0	1089550.ATTH01000001_gene1728	3.251e-160	524.0	COG0178@1|root,COG0178@2|Bacteria,4NEHM@976|Bacteroidetes,1FJ58@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA1	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_21,ABC_tran
TLS2_k127_7054670_1	880073.Calab_3149	2.529e-105	355.0	COG0301@1|root,COG0301@2|Bacteria,2NPBT@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307	THUMP,ThiI
TLS2_k127_7054670_3	1121413.JMKT01000010_gene878	1.298e-19	98.0	COG3656@1|root,COG3656@2|Bacteria	2|Bacteria	N	Periplasmic Protein	-	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	DUF2271,FLgD_tudor,FlgD,FlgD_ig,PKD
TLS2_k127_7054670_2	43989.cce_4327	5.283e-35	146.0	COG0667@1|root,COG0667@2|Bacteria,1G2DX@1117|Cyanobacteria,3KGHU@43988|Cyanothece	1117|Cyanobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_7054670_0	522772.Dacet_2287	7.804e-152	490.0	COG0162@1|root,COG0162@2|Bacteria,2GENZ@200930|Deferribacteres	200930|Deferribacteres	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TLS2_k127_7070497_5	204669.Acid345_2940	6.397e-34	132.0	COG2234@1|root,COG2234@2|Bacteria,3Y3SC@57723|Acidobacteria,2JIVJ@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_7070497_2	1128427.KB904821_gene2717	4.895e-117	387.0	28KU8@1|root,2ZCM9@2|Bacteria,1G5AX@1117|Cyanobacteria,1HAQ7@1150|Oscillatoriales	1117|Cyanobacteria	S	STELLO glycosyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	STELLO
TLS2_k127_7070497_0	1288963.ADIS_0251	7.459e-146	470.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_7070497_3	1283300.ATXB01000002_gene3078	2.811e-59	224.0	COG2202@1|root,COG2208@1|root,COG3290@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2208@2|Bacteria,COG3290@2|Bacteria,COG3829@2|Bacteria,1RGZF@1224|Proteobacteria,1S6GG@1236|Gammaproteobacteria,1XDM4@135618|Methylococcales	135618|Methylococcales	KT	PFAM Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	PAS_9,SpoIIE
TLS2_k127_7070497_1	926550.CLDAP_40360	1.105e-144	471.0	COG0399@1|root,COG0399@2|Bacteria,2G7J4@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_7070497_4	1128427.KB904821_gene2716	2.756e-43	164.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
TLS2_k127_7088440_4	1121381.JNIV01000193_gene2718	9.53e-09	60.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7088440_1	595460.RRSWK_05984	3.981e-32	130.0	COG3344@1|root,COG3344@2|Bacteria,2J0GH@203682|Planctomycetes	203682|Planctomycetes	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
TLS2_k127_7088440_0	234267.Acid_2016	8.839e-77	260.0	COG3344@1|root,COG3344@2|Bacteria,3Y46K@57723|Acidobacteria	57723|Acidobacteria	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1,RVT_N
TLS2_k127_7088440_3	270374.MELB17_09248	4.851e-12	66.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,466QE@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG3344 Retron-type reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
TLS2_k127_7088440_2	244582.JQAK01000002_gene550	1.857e-18	86.0	COG1961@1|root,COG1961@2|Bacteria,1RBKN@1224|Proteobacteria,2U6XS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_7,Resolvase
TLS2_k127_709613_10	880073.Calab_3483	1.585e-47	173.0	COG3033@1|root,COG3033@2|Bacteria,2NNZV@2323|unclassified Bacteria	2|Bacteria	E	Beta-eliminating lyase	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_709613_6	518766.Rmar_1596	2.839e-92	312.0	COG0010@1|root,COG0010@2|Bacteria,4NEFA@976|Bacteroidetes	976|Bacteroidetes	E	Belongs to the arginase family	hutG	-	3.5.3.7,3.5.3.8	ko:K01479,ko:K12255	ko00330,ko00340,ko01100,map00330,map00340,map01100	M00045	R01990,R02285	RC00024,RC00221,RC00329,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS2_k127_709613_4	518766.Rmar_1595	2.075e-147	478.0	COG1228@1|root,COG1228@2|Bacteria,4NE6C@976|Bacteroidetes	976|Bacteroidetes	Q	Belongs to the metallo-dependent hydrolases superfamily. HutI family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
TLS2_k127_709613_1	518766.Rmar_1594	7.328e-225	707.0	COG2986@1|root,COG2986@2|Bacteria,4NE0D@976|Bacteroidetes,1FJTU@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
TLS2_k127_709613_0	518766.Rmar_1593	3.549e-229	715.0	COG2987@1|root,COG2987@2|Bacteria,4NF2P@976|Bacteroidetes	976|Bacteroidetes	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
TLS2_k127_709613_12	1460640.JCM19046_2095	8.354e-47	170.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,4H9NH@91061|Bacilli,1ZCMM@1386|Bacillus	91061|Bacilli	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
TLS2_k127_709613_2	867903.ThesuDRAFT_01213	8.461e-201	634.0	COG0114@1|root,COG0114@2|Bacteria,1UHPH@1239|Firmicutes,25F3I@186801|Clostridia,3WCCI@538999|Clostridiales incertae sedis	186801|Clostridia	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
TLS2_k127_709613_7	861299.J421_0843	1.066e-79	278.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	pqqC	-	1.3.3.11	ko:K06137,ko:K06138	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,PqqD,Radical_SAM,SPASM,TENA_THI-4
TLS2_k127_709613_8	1267535.KB906767_gene5044	9.645e-68	237.0	COG4221@1|root,COG4221@2|Bacteria,3Y4DX@57723|Acidobacteria	57723|Acidobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_709613_3	251221.35211608	1.462e-157	504.0	COG1899@1|root,COG1899@2|Bacteria,1G448@1117|Cyanobacteria	1117|Cyanobacteria	O	Belongs to the deoxyhypusine synthase family	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
TLS2_k127_709613_5	656519.Halsa_1987	5.621e-97	332.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia	186801|Clostridia	S	Conserved protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
TLS2_k127_709613_11	1301098.PKB_1035	2.592e-47	179.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	2.1.1.200	ko:K02533,ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
TLS2_k127_709613_9	648996.Theam_0678	3.322e-66	234.0	COG0436@1|root,COG0436@2|Bacteria,2G3VY@200783|Aquificae	200783|Aquificae	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_7100375_1	1173025.GEI7407_0046	1.921e-77	262.0	COG1839@1|root,COG1839@2|Bacteria,1G575@1117|Cyanobacteria,1HAQX@1150|Oscillatoriales	1117|Cyanobacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
TLS2_k127_7100375_3	204669.Acid345_3527	6.585e-15	78.0	COG0457@1|root,COG0457@2|Bacteria	204669.Acid345_3527|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7100375_2	517418.Ctha_1581	1.551e-56	214.0	COG0612@1|root,COG0612@2|Bacteria,1FEWA@1090|Chlorobi	1090|Chlorobi	S	Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_7100375_0	1191523.MROS_1246	2.965e-89	309.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_7106222_1	1382359.JIAL01000001_gene1957	3.812e-56	201.0	COG3808@1|root,COG3808@2|Bacteria,3Y34E@57723|Acidobacteria,2JJHT@204432|Acidobacteriia	204432|Acidobacteriia	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS2_k127_7106222_0	985255.APHJ01000026_gene2294	5.584e-143	469.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,1HXRM@117743|Flavobacteriia,2P7GH@244698|Gillisia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C,TAT_signal
TLS2_k127_7106222_2	1047013.AQSP01000139_gene2325	2.869e-44	171.0	COG3595@1|root,COG3595@2|Bacteria,2NQ1F@2323|unclassified Bacteria	2|Bacteria	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_7111952_2	1121918.ARWE01000001_gene3081	6.677e-95	319.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria,43V7G@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1,1.2.7.7	ko:K00170,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
TLS2_k127_7111952_1	1121918.ARWE01000001_gene3080	1.822e-107	361.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,43TT3@69541|Desulfuromonadales	68525|delta/epsilon subdivisions	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
TLS2_k127_7111952_0	1121918.ARWE01000001_gene3079	8.433e-137	457.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42P5P@68525|delta/epsilon subdivisions,2WITN@28221|Deltaproteobacteria,43TQJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	HI0933-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_9,Pyr_redox_2
TLS2_k127_7113713_2	1144275.COCOR_00422	3.456e-59	209.0	COG3871@1|root,COG3871@2|Bacteria,1RF7K@1224|Proteobacteria,431CF@68525|delta/epsilon subdivisions,2WX0W@28221|Deltaproteobacteria,2Z189@29|Myxococcales	28221|Deltaproteobacteria	S	Pyridoxamine 5'-phosphate oxidase like	-	-	-	-	-	-	-	-	-	-	-	-	Pyrid_ox_like
TLS2_k127_7113713_1	234267.Acid_1586	2.595e-82	278.0	COG2129@1|root,COG2129@2|Bacteria	2|Bacteria	L	metallophosphoesterase	-	-	-	ko:K07096,ko:K07496	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2,Metallophos_3
TLS2_k127_7113713_0	1267535.KB906767_gene4419	2.647e-92	308.0	COG1186@1|root,COG1186@2|Bacteria,3Y2ZM@57723|Acidobacteria,2JIGW@204432|Acidobacteriia	204432|Acidobacteriia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS2_k127_7113740_0	404589.Anae109_1212	3.213e-101	356.0	COG0204@1|root,COG1022@1|root,COG3320@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,COG3320@2|Bacteria,1MU4D@1224|Proteobacteria,42NHQ@68525|delta/epsilon subdivisions,2WJZ5@28221|Deltaproteobacteria,2YU6Q@29|Myxococcales	28221|Deltaproteobacteria	IQ	Male sterility protein	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,NAD_binding_4,PP-binding,Sterile
TLS2_k127_7122384_0	682795.AciX8_3257	1.875e-93	342.0	COG3485@1|root,COG3485@2|Bacteria,3Y3R9@57723|Acidobacteria,2JHNH@204432|Acidobacteriia	204432|Acidobacteriia	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_7124731_1	1173264.KI913950_gene4519	7.561e-83	287.0	COG2936@1|root,COG2936@2|Bacteria,1G1U8@1117|Cyanobacteria,1H7W3@1150|Oscillatoriales	1117|Cyanobacteria	S	Hydrolase CocE NonD family	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
TLS2_k127_7124731_4	1122605.KB893629_gene4178	4.986e-07	53.0	COG3250@1|root,COG3250@2|Bacteria,4NFE8@976|Bacteroidetes,1IUZ7@117747|Sphingobacteriia	976|Bacteroidetes	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
TLS2_k127_7124731_2	1121943.KB899999_gene1293	2.724e-47	181.0	COG1011@1|root,COG1011@2|Bacteria,1QSY2@1224|Proteobacteria,1RWK3@1236|Gammaproteobacteria,1XM90@135619|Oceanospirillales	135619|Oceanospirillales	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	3.1.3.10	ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_7124731_0	1307759.JOMJ01000003_gene1044	6.116e-120	403.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria,2M8CP@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS2_k127_7124731_3	1118054.CAGW01000074_gene870	3.714e-15	80.0	COG5002@1|root,COG5002@2|Bacteria,1TS5K@1239|Firmicutes,4H9Y1@91061|Bacilli,277BU@186822|Paenibacillaceae	91061|Bacilli	T	His Kinase A (phosphoacceptor) domain	ciaH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K14982	ko02020,ko02024,map02020,map02024	M00521	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
TLS2_k127_7124731_5	682795.AciX8_3967	2.366e-05	51.0	COG0745@1|root,COG0745@2|Bacteria,3Y4R4@57723|Acidobacteria,2JJBD@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_7130107_8	1430440.MGMSRv2_2310	0.0001576	49.0	COG4818@1|root,COG4818@2|Bacteria	2|Bacteria	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7130107_6	512565.AMIS_63870	1.304e-08	59.0	COG0759@1|root,COG0759@2|Bacteria	2|Bacteria	M	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
TLS2_k127_7130107_5	635013.TherJR_2805	5.69e-34	148.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1TQIK@1239|Firmicutes,249Y6@186801|Clostridia,267E8@186807|Peptococcaceae	186801|Clostridia	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF
TLS2_k127_7130107_3	693444.D782_1360	1.791e-65	228.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,2835N@191675|unclassified Enterobacteriaceae	1236|Gammaproteobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2311,iAPECO1_1312.APECO1_4253,iB21_1397.B21_02196,iBWG_1329.BWG_2085,iE2348C_1286.E2348C_2451,iEC55989_1330.EC55989_2555,iECBD_1354.ECBD_1348,iECB_1328.ECB_02236,iECDH10B_1368.ECDH10B_2473,iECDH1ME8569_1439.ECDH1ME8569_2249,iECD_1391.ECD_02236,iECED1_1282.ECED1_2775,iECH74115_1262.ECH74115_3451,iECIAI39_1322.ECIAI39_2460,iECNA114_1301.ECNA114_2401,iECO103_1326.ECO103_2775,iECOK1_1307.ECOK1_2544,iECP_1309.ECP_2350,iECS88_1305.ECS88_2458,iECSE_1348.ECSE_2620,iECSF_1327.ECSF_2187,iECSP_1301.ECSP_3186,iECs_1301.ECs3195,iETEC_1333.ETEC_2447,iEcDH1_1363.EcDH1_1345,iEcE24377_1341.EcE24377A_2605,iEcHS_1320.EcHS_A2462,iEcSMS35_1347.EcSMS35_2467,iG2583_1286.G2583_2848,iJO1366.b2311,iJR904.b2311,iLF82_1304.LF82_2354,iNRG857_1313.NRG857_11705,iSDY_1059.SDY_2510,iUMN146_1321.UM146_05255,iUMNK88_1353.UMNK88_2862,iUTI89_1310.UTI89_C2595,iY75_1357.Y75_RS12120,iZ_1308.Z3573	Flavoprotein
TLS2_k127_7130107_4	552811.Dehly_0476	9.043e-57	207.0	COG0428@1|root,COG0428@2|Bacteria,2G671@200795|Chloroflexi	200795|Chloroflexi	P	ZIP Zinc transporter	-	-	-	ko:K07238,ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11,2.A.5.5	-	-	Zip
TLS2_k127_7130107_0	471854.Dfer_0267	3.009e-150	483.0	COG0673@1|root,COG0673@2|Bacteria,4NIH0@976|Bacteroidetes,47JXQ@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_7130107_1	717605.Theco_2601	1.001e-135	443.0	COG0524@1|root,COG0524@2|Bacteria,1TT7Y@1239|Firmicutes,4HC0B@91061|Bacilli,26U8T@186822|Paenibacillaceae	91061|Bacilli	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS2_k127_7130107_2	697281.Mahau_2725	1.471e-88	304.0	COG0407@1|root,COG0407@2|Bacteria,1TR8Q@1239|Firmicutes,24B2U@186801|Clostridia,42IQ4@68295|Thermoanaerobacterales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	2.1.1.246,4.1.1.37	ko:K01599,ko:K14080	ko00680,ko00860,ko01100,ko01110,ko01120,ko01200,map00680,map00860,map01100,map01110,map01120,map01200	M00121,M00356	R03197,R04972,R09098,R10000	RC00035,RC00872,RC01144,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS2_k127_7130107_7	911104.AEKT01000028_gene1559	3.943e-05	55.0	COG0457@1|root,COG0457@2|Bacteria,1VFGR@1239|Firmicutes,4HNQ2@91061|Bacilli	91061|Bacilli	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
TLS2_k127_7130182_3	649638.Trad_0884	2.472e-35	138.0	COG1873@1|root,COG1873@2|Bacteria	2|Bacteria	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
TLS2_k127_7130182_1	211110.gbs0894	1.404e-118	406.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4HBVV@91061|Bacilli	91061|Bacilli	S	abc transporter atp-binding protein	ydiF	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
TLS2_k127_7130182_0	234267.Acid_6511	2.185e-144	477.0	COG2234@1|root,COG2234@2|Bacteria,3Y3S9@57723|Acidobacteria	57723|Acidobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
TLS2_k127_7130182_2	313624.NSP_14580	6.776e-85	298.0	COG0277@1|root,COG0277@2|Bacteria,1G6C2@1117|Cyanobacteria,1HIC7@1161|Nostocales	1117|Cyanobacteria	C	FAD binding domain	-	-	1.1.3.8,1.5.99.12	ko:K00103,ko:K00279	ko00053,ko00908,ko01100,map00053,map00908,map01100	M00129	R00647,R03184,R05708,R10053	RC00121,RC00195,RC00346,RC00869,RC01455	ko00000,ko00001,ko00002,ko01000	-	-	-	ALO,Cytokin-bind,FAD_binding_4
TLS2_k127_7130182_4	497964.CfE428DRAFT_1693	1.862e-34	144.0	COG0859@1|root,COG0859@2|Bacteria,46SZK@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
TLS2_k127_7130410_0	1047013.AQSP01000139_gene2342	2.261e-199	632.0	COG1529@1|root,COG1529@2|Bacteria,2NPHP@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_7130410_1	670292.JH26_17745	4.092e-42	158.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2U9M7@28211|Alphaproteobacteria,1JUJ6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Class I peptide chain release factor	MA20_05665	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
TLS2_k127_7130410_2	1047013.AQSP01000144_gene895	1.096e-34	136.0	COG2242@1|root,COG2242@2|Bacteria	2|Bacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
TLS2_k127_7135393_7	323261.Noc_0914	2.303e-49	183.0	COG0500@1|root,COG2226@2|Bacteria,1MVIS@1224|Proteobacteria,1S5K2@1236|Gammaproteobacteria,1X0P5@135613|Chromatiales	135613|Chromatiales	Q	Methyltransferase type 11	-	-	2.1.1.17,2.1.1.71	ko:K00570	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00091	R01320,R02056,R03424	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
TLS2_k127_7135393_5	1121423.JONT01000010_gene1742	3.816e-63	223.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,261JF@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS2_k127_7135393_4	562970.Btus_2586	5.06e-73	250.0	COG2316@1|root,COG2316@2|Bacteria,1TSF7@1239|Firmicutes,4HTP0@91061|Bacilli,279M4@186823|Alicyclobacillaceae	91061|Bacilli	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
TLS2_k127_7135393_0	309801.trd_0711	4.883e-313	970.0	COG0365@1|root,COG0365@2|Bacteria,2G5KE@200795|Chloroflexi,27XEK@189775|Thermomicrobia	189775|Thermomicrobia	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_7135393_3	1120973.AQXL01000125_gene3179	8.082e-136	444.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,4HDCE@91061|Bacilli	91061|Bacilli	S	Domain of unknown function (DUF2088)	larA	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
TLS2_k127_7135393_1	240015.ACP_0176	4.501e-169	539.0	COG1960@1|root,COG1960@2|Bacteria,3Y2FM@57723|Acidobacteria,2JIVG@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_7135393_8	44689.DDB0190849	2.948e-29	129.0	COG0237@1|root,2STE9@2759|Eukaryota,3XC8Z@554915|Amoebozoa	554915|Amoebozoa	H	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
TLS2_k127_7135393_6	313628.LNTAR_01145	1.676e-53	201.0	COG2131@1|root,COG2131@2|Bacteria	2|Bacteria	F	dCMP deaminase activity	dcdA	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
TLS2_k127_7135393_2	240015.ACP_2461	1.022e-163	526.0	COG0015@1|root,COG0015@2|Bacteria,3Y2QW@57723|Acidobacteria,2JIAC@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
TLS2_k127_7135393_9	204669.Acid345_4326	6.148e-24	103.0	COG1235@1|root,COG1235@2|Bacteria,3Y3DW@57723|Acidobacteria,2JI3X@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_7137565_3	1123508.JH636440_gene2300	3.743e-13	73.0	COG1793@1|root,COG1793@2|Bacteria,2IYJZ@203682|Planctomycetes	203682|Planctomycetes	L	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_7137565_0	1254432.SCE1572_39135	5.377e-81	276.0	COG1794@1|root,COG1794@2|Bacteria,1PRP1@1224|Proteobacteria,43DME@68525|delta/epsilon subdivisions,2WZYC@28221|Deltaproteobacteria,2Z2CP@29|Myxococcales	28221|Deltaproteobacteria	M	Asp/Glu/Hydantoin racemase	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
TLS2_k127_7137565_2	344747.PM8797T_30449	8.522e-44	173.0	294P7@1|root,2ZS2I@2|Bacteria,2J4KK@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7137565_1	234267.Acid_3611	1.35e-71	251.0	COG1734@1|root,COG2208@1|root,COG1734@2|Bacteria,COG2208@2|Bacteria,3Y4RV@57723|Acidobacteria	57723|Acidobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
TLS2_k127_714491_1	1121920.AUAU01000002_gene2033	4.579e-107	356.0	COG0013@1|root,COG0013@2|Bacteria,3Y4AR@57723|Acidobacteria	57723|Acidobacteria	J	Threonyl and Alanyl tRNA synthetase second additional domain	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS2_k127_714491_2	448385.sce2438	4.995e-101	339.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,42UHT@68525|delta/epsilon subdivisions,2WR0M@28221|Deltaproteobacteria,2YUP9@29|Myxococcales	28221|Deltaproteobacteria	C	oxidase, subunit	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
TLS2_k127_714491_0	886293.Sinac_4610	2.802e-161	518.0	COG1271@1|root,COG1271@2|Bacteria,2IXYC@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome bd-type quinol oxidase subunit 1	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
TLS2_k127_714491_3	338966.Ppro_1435	1.145e-24	111.0	COG0727@1|root,COG0727@2|Bacteria,1N3UP@1224|Proteobacteria,42U10@68525|delta/epsilon subdivisions,2WQ8S@28221|Deltaproteobacteria,43V2K@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
TLS2_k127_7145689_0	1267535.KB906767_gene99	0.0	1295.0	COG0542@1|root,COG0542@2|Bacteria,3Y2X9@57723|Acidobacteria,2JIAE@204432|Acidobacteriia	204432|Acidobacteriia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS2_k127_7145689_1	644282.Deba_0407	2.794e-08	56.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS2_k127_7146353_1	177437.HRM2_39500	2.811e-73	254.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42NG2@68525|delta/epsilon subdivisions,2WK33@28221|Deltaproteobacteria,2MPZS@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Bacterial dnaA  protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
TLS2_k127_7146353_0	485915.Dret_1175	2.138e-153	501.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42SM4@68525|delta/epsilon subdivisions,2WPVD@28221|Deltaproteobacteria,2MGHY@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_7148084_1	1123242.JH636435_gene1232	3.975e-45	170.0	COG1349@1|root,COG1349@2|Bacteria,2IYW0@203682|Planctomycetes	203682|Planctomycetes	K	COG1349 Transcriptional regulators of sugar metabolism	-	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
TLS2_k127_7148084_0	886293.Sinac_0541	7.673e-88	301.0	COG0546@1|root,COG0546@2|Bacteria,2IZVE@203682|Planctomycetes	203682|Planctomycetes	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_7148084_3	765912.Thimo_0840	3.88e-31	125.0	COG1342@1|root,COG1433@1|root,COG1342@2|Bacteria,COG1433@2|Bacteria,1N80T@1224|Proteobacteria,1S9DC@1236|Gammaproteobacteria,1WZ10@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0251 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF134
TLS2_k127_7148084_2	1121918.ARWE01000001_gene2087	6.364e-35	137.0	COG1433@1|root,COG1433@2|Bacteria,1N56C@1224|Proteobacteria,42TK7@68525|delta/epsilon subdivisions,2WQ0G@28221|Deltaproteobacteria,43VPF@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
TLS2_k127_71574_1	65093.PCC7418_1265	1.956e-96	318.0	COG0493@1|root,COG0493@2|Bacteria,1G0SD@1117|Cyanobacteria	1117|Cyanobacteria	C	TIGRFAM glutamate synthases, NADH NADPH, small subunit	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iJN678.gltD	Fer4_20,Pyr_redox_2
TLS2_k127_71574_2	479434.Sthe_3173	1.175e-77	267.0	COG4976@1|root,COG4976@2|Bacteria	2|Bacteria	O	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,Glycos_transf_1,Glycos_transf_2,Methyltransf_23,Methyltransf_25
TLS2_k127_71574_3	56780.SYN_00759	5.003e-30	124.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,42SH8@68525|delta/epsilon subdivisions,2WQ3S@28221|Deltaproteobacteria,2MQNY@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS2_k127_71574_0	1408473.JHXO01000001_gene2487	1.135e-151	493.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,2FQ0Q@200643|Bacteroidia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_7158227_2	234267.Acid_5546	1.513e-26	111.0	COG1024@1|root,COG1250@1|root,COG3033@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,COG3033@2|Bacteria,3Y2RB@57723|Acidobacteria	57723|Acidobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
TLS2_k127_7158227_0	234267.Acid_5547	3.417e-92	317.0	COG0392@1|root,COG0392@2|Bacteria,3Y7S6@57723|Acidobacteria	57723|Acidobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
TLS2_k127_7158227_1	234267.Acid_5591	3.062e-54	198.0	COG1845@1|root,COG1845@2|Bacteria,3Y2KJ@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
TLS2_k127_7174543_2	767817.Desgi_3212	2.65e-16	83.0	COG4826@1|root,COG4826@2|Bacteria,1UYKX@1239|Firmicutes,24B76@186801|Clostridia,260NR@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Dockerin_1,Serpin
TLS2_k127_7174543_1	1121377.KB906418_gene3787	6.128e-60	217.0	COG5640@1|root,COG5640@2|Bacteria,1WN2M@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Trypsin-like serine protease	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin
TLS2_k127_7174543_0	497964.CfE428DRAFT_6514	2.999e-86	294.0	COG1408@1|root,COG1408@2|Bacteria	2|Bacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
TLS2_k127_7174698_0	880072.Desac_2440	1.052e-229	724.0	COG0574@1|root,COG0574@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2MR7X@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
TLS2_k127_7174698_1	1047013.AQSP01000131_gene1819	4.883e-96	333.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,DUF4625,NPCBM_assoc,PEGA
TLS2_k127_7174698_2	1235803.C825_05279	2.482e-45	168.0	COG1131@1|root,COG1131@2|Bacteria,4NE3Z@976|Bacteroidetes,2FR55@200643|Bacteroidia,22ZR5@171551|Porphyromonadaceae	976|Bacteroidetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_7177619_1	886293.Sinac_5200	5.078e-85	292.0	2DBQG@1|root,2ZADX@2|Bacteria,2IZGN@203682|Planctomycetes	203682|Planctomycetes	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_7177619_0	335543.Sfum_1073	1.605e-140	452.0	COG4868@1|root,COG4868@2|Bacteria,1NN03@1224|Proteobacteria,42P46@68525|delta/epsilon subdivisions,2WKVV@28221|Deltaproteobacteria,2MR6J@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1846)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1846
TLS2_k127_7186383_2	1123240.ATVO01000008_gene2480	1.983e-10	63.0	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1MV1V@1224|Proteobacteria,2VEVE@28211|Alphaproteobacteria,2K2KU@204457|Sphingomonadales	204457|Sphingomonadales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,Guanylate_cyc,PAS_4
TLS2_k127_7186383_1	502025.Hoch_4790	9.539e-118	397.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2YYCB@29|Myxococcales	28221|Deltaproteobacteria	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_7186383_0	1499967.BAYZ01000097_gene4380	6.088e-280	882.0	COG0550@1|root,COG0550@2|Bacteria,2NNS8@2323|unclassified Bacteria	2|Bacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
TLS2_k127_7190509_2	525373.HMPREF0766_13313	3.026e-08	59.0	COG0457@1|root,COG3049@1|root,COG0457@2|Bacteria,COG3049@2|Bacteria,4NIRM@976|Bacteroidetes,1J18T@117747|Sphingobacteriia	976|Bacteroidetes	M	Glycogen recognition site of AMP-activated protein kinase	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	AAT,AMPK1_CBM,CBAH
TLS2_k127_7190509_0	497964.CfE428DRAFT_3322	1.645e-80	284.0	COG0715@1|root,COG0715@2|Bacteria,46U6U@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Protein of unknown function (DUF3500)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3500
TLS2_k127_7190509_1	335543.Sfum_1483	3.47e-49	179.0	COG0484@1|root,COG0484@2|Bacteria,1RHHJ@1224|Proteobacteria,42SMN@68525|delta/epsilon subdivisions,2WPJN@28221|Deltaproteobacteria,2MRYE@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
TLS2_k127_719203_0	661478.OP10G_0108	6.67e-85	301.0	COG0323@1|root,COG0323@2|Bacteria	2|Bacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
TLS2_k127_7195554_1	740709.A10D4_06231	1.338e-29	125.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,1SA4Q@1236|Gammaproteobacteria,2QG31@267893|Idiomarinaceae	1236|Gammaproteobacteria	L	NUDIX domain	nudL	GO:0003674,GO:0003824,GO:0016787,GO:0016817,GO:0016818	-	-	-	-	-	-	-	-	-	-	DUF1289,NUDIX
TLS2_k127_7195554_3	886379.AEWI01000030_gene305	2.217e-09	63.0	COG4770@1|root,COG4770@2|Bacteria,4NWQ0@976|Bacteroidetes,2FUXX@200643|Bacteroidia,3XKCE@558415|Marinilabiliaceae	976|Bacteroidetes	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
TLS2_k127_7195554_0	385682.AFSL01000009_gene2505	5.452e-216	683.0	COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,2FPY6@200643|Bacteroidia,3XJAQ@558415|Marinilabiliaceae	976|Bacteroidetes	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
TLS2_k127_7195554_2	204669.Acid345_0818	1.642e-29	132.0	COG2091@1|root,COG2091@2|Bacteria,3Y46J@57723|Acidobacteria,2JHWP@204432|Acidobacteriia	204432|Acidobacteriia	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7207203_2	1122222.AXWR01000001_gene1848	1.321e-59	214.0	COG0155@1|root,COG0155@2|Bacteria,1WIU8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Nitrite and sulphite reductase 4Fe-4S	-	-	1.7.7.1,1.8.1.2,1.8.7.1	ko:K00366,ko:K00381,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00858,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
TLS2_k127_7207203_0	1195236.CTER_3122	1.66e-201	645.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1TQXK@1239|Firmicutes,25EK3@186801|Clostridia,3WISI@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysC	-	2.7.1.25,2.7.7.4	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D3
TLS2_k127_7207203_1	720554.Clocl_3418	6.202e-146	471.0	COG0175@1|root,COG0175@2|Bacteria,1U1VN@1239|Firmicutes,248Y9@186801|Clostridia,3WJJK@541000|Ruminococcaceae	186801|Clostridia	EH	PFAM Phosphoadenosine phosphosulfate reductase	cysD	-	1.8.4.10,1.8.4.8,2.7.7.4	ko:K00390,ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R02021,R04929	RC00007,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TLS2_k127_7207203_3	709991.Odosp_1215	7.983e-43	159.0	COG0175@1|root,COG0175@2|Bacteria,4NGVI@976|Bacteroidetes,2FPGR@200643|Bacteroidia,2301I@171551|Porphyromonadaceae	976|Bacteroidetes	C	Reduction of activated sulfate into sulfite	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TLS2_k127_7229993_0	1121904.ARBP01000037_gene2055	1.333e-183	585.0	COG2407@1|root,COG2407@2|Bacteria,4NF0C@976|Bacteroidetes,47JET@768503|Cytophagia	976|Bacteroidetes	G	Catalyzes the conversion of L-arabinose to L-ribulose	-	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Isome,Fucose_iso_C
TLS2_k127_7229993_1	639030.JHVA01000001_gene3704	8.667e-117	391.0	COG2271@1|root,COG2271@2|Bacteria,3Y2VG@57723|Acidobacteria,2JIWZ@204432|Acidobacteriia	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
TLS2_k127_7229993_2	1340493.JNIF01000003_gene3565	5.546e-63	229.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_7242858_1	234267.Acid_3989	1.833e-53	199.0	COG2006@1|root,COG2006@2|Bacteria,3Y6M1@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
TLS2_k127_7242858_0	525904.Tter_2267	2.786e-170	545.0	COG4948@1|root,COG4948@2|Bacteria,2NQCI@2323|unclassified Bacteria	2|Bacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	rspA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0008927,GO:0009056,GO:0016052,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044238,GO:0046872,GO:0047929,GO:0071704,GO:1901575	4.2.1.8	ko:K08323	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_7242858_2	204669.Acid345_3020	3.434e-44	169.0	COG2834@1|root,COG2834@2|Bacteria,3Y7NW@57723|Acidobacteria	57723|Acidobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7254359_1	1131814.JAFO01000001_gene466	1.424e-88	301.0	COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria,1NTJT@1224|Proteobacteria,2U3YQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7254359_3	903818.KI912268_gene1409	3.372e-38	155.0	COG2010@1|root,COG2010@2|Bacteria,3Y5X3@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,FixO
TLS2_k127_7254359_0	945713.IALB_1391	5.441e-94	322.0	COG4531@1|root,COG4531@2|Bacteria	2|Bacteria	P	zinc ion transport	actF	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7254359_2	1191523.MROS_0042	3.924e-74	260.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	actE	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,DUF3341
TLS2_k127_7254866_1	1000565.METUNv1_02473	6.514e-06	53.0	COG1714@1|root,COG1714@2|Bacteria,1REEC@1224|Proteobacteria,2VRE0@28216|Betaproteobacteria,2KWXJ@206389|Rhodocyclales	206389|Rhodocyclales	S	membrane protein domain	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS2_k127_7254866_0	1382359.JIAL01000001_gene613	1.106e-75	273.0	COG3292@1|root,COG4447@1|root,COG3292@2|Bacteria,COG4447@2|Bacteria,3Y3Y6@57723|Acidobacteria,2JI5Y@204432|Acidobacteriia	204432|Acidobacteriia	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
TLS2_k127_726184_4	1219077.VAZ01S_029_00110	4.682e-12	76.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1XUE7@135623|Vibrionales	135623|Vibrionales	D	COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TLS2_k127_726184_0	1267535.KB906767_gene448	1.188e-160	523.0	COG0595@1|root,COG0595@2|Bacteria,3Y2NH@57723|Acidobacteria,2JI53@204432|Acidobacteriia	204432|Acidobacteriia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
TLS2_k127_726184_2	398767.Glov_2313	4.994e-50	188.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,42QAC@68525|delta/epsilon subdivisions,2WN8H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TLS2_k127_726184_3	1000565.METUNv1_02525	8.686e-37	141.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2VSHX@28216|Betaproteobacteria,2KWAV@206389|Rhodocyclales	206389|Rhodocyclales	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS2_k127_726184_1	926692.AZYG01000047_gene2658	1.854e-101	338.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,3WAAB@53433|Halanaerobiales	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
TLS2_k127_7285999_3	1121428.DESHY_50085___1	1.77e-50	190.0	COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia,261JW@186807|Peptococcaceae	186801|Clostridia	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_7285999_1	575540.Isop_3575	3.06e-167	539.0	COG0531@1|root,COG0531@2|Bacteria,2IXT5@203682|Planctomycetes	203682|Planctomycetes	E	PFAM Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_7285999_0	1121468.AUBR01000017_gene2367	1.401e-180	589.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,42EUR@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM UvrD REP helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS2_k127_7285999_4	1391647.AVSV01000014_gene442	2.047e-07	62.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,36DTS@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
TLS2_k127_7285999_2	1499967.BAYZ01000061_gene5954	1.407e-71	252.0	COG1533@1|root,COG1533@2|Bacteria,2NPZ9@2323|unclassified Bacteria	2|Bacteria	L	DNA photolyase activity	-	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
TLS2_k127_7292197_5	1150600.ADIARSV_2993	3.118e-09	68.0	2CDBG@1|root,343FF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7292197_1	234267.Acid_7166	3.665e-37	147.0	COG2353@1|root,COG2353@2|Bacteria	2|Bacteria	O	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
TLS2_k127_7292197_0	1267533.KB906733_gene3541	9.538e-62	223.0	COG0457@1|root,COG0457@2|Bacteria,3Y4KP@57723|Acidobacteria,2JMF3@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7292197_3	240015.ACP_0351	5.534e-30	121.0	2C4KB@1|root,32YM4@2|Bacteria,3Y5RS@57723|Acidobacteria,2JK1H@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7292197_4	153948.NAL212_0962	5.045e-23	110.0	COG2304@1|root,COG2304@2|Bacteria,1PE8B@1224|Proteobacteria,2WC99@28216|Betaproteobacteria,374H0@32003|Nitrosomonadales	28216|Betaproteobacteria	S	C-type lectin (CTL) or carbohydrate-recognition domain (CRD)	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
TLS2_k127_729260_2	1536774.H70357_16450	1.301e-06	51.0	COG1643@1|root,COG1643@2|Bacteria,1TPET@1239|Firmicutes,4HE8W@91061|Bacilli,26U7B@186822|Paenibacillaceae	91061|Bacilli	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
TLS2_k127_729260_3	4792.ETI53056	3.019e-05	55.0	COG0405@1|root,KOG2410@2759|Eukaryota,3QDFY@4776|Peronosporales	4776|Peronosporales	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_729260_0	1499967.BAYZ01000018_gene6342	3.025e-44	172.0	COG3506@1|root,COG3506@2|Bacteria	2|Bacteria	M	Protein of unknown function (DUF1349)	yjl217W	-	-	ko:K09702	-	-	-	-	ko00000	-	-	-	DUF1349
TLS2_k127_729260_1	1232453.BAIF02000054_gene1170	1.425e-24	114.0	COG2017@1|root,COG2017@2|Bacteria,1VGHI@1239|Firmicutes	1239|Firmicutes	G	galactose mutarotase	yoxA	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
TLS2_k127_7301767_2	661478.OP10G_2023	1.107e-16	86.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K07506	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,Chrome_Resist,HTH_18
TLS2_k127_7301767_1	251221.35213116	4.531e-99	337.0	COG0793@1|root,COG0793@2|Bacteria,1G58N@1117|Cyanobacteria	1117|Cyanobacteria	M	N-terminal domain of Peptidase_S41 in eukaryotic IRBP	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41,Peptidase_S41_N
TLS2_k127_7301767_0	215803.DB30_4900	1.163e-119	400.0	COG1680@1|root,COG1680@2|Bacteria,1PEI7@1224|Proteobacteria,43DSW@68525|delta/epsilon subdivisions,2X8V3@28221|Deltaproteobacteria,2Z0DE@29|Myxococcales	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_7315093_0	765952.PUV_02650	8.398e-158	509.0	COG3185@1|root,COG3185@2|Bacteria,2JFPQ@204428|Chlamydiae	204428|Chlamydiae	E	Pfam:DUF1446	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
TLS2_k127_7315093_3	765952.PUV_02640	2.864e-27	115.0	2CIU6@1|root,32S8H@2|Bacteria,2JGEN@204428|Chlamydiae	204428|Chlamydiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7315093_1	765952.PUV_02630	1.79e-58	212.0	COG1024@1|root,COG1024@2|Bacteria,2JGC4@204428|Chlamydiae	204428|Chlamydiae	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_7315093_2	1121422.AUMW01000024_gene269	3.518e-37	147.0	COG0842@1|root,COG0842@2|Bacteria,1TSWD@1239|Firmicutes,24EPB@186801|Clostridia,26013@186807|Peptococcaceae	186801|Clostridia	V	ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
TLS2_k127_7319122_4	204669.Acid345_4630	1.887e-08	58.0	COG0577@1|root,COG0577@2|Bacteria,3Y2IG@57723|Acidobacteria,2JHUY@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_7319122_3	204669.Acid345_4631	5.246e-31	128.0	COG0577@1|root,COG0577@2|Bacteria,3Y3X9@57723|Acidobacteria,2JHKJ@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_7319122_2	1267534.KB906759_gene1828	6.689e-48	180.0	COG0577@1|root,COG0577@2|Bacteria,3Y3X9@57723|Acidobacteria,2JHKJ@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_7319122_0	1353531.AZNX01000005_gene3327	1.462e-152	499.0	COG4287@1|root,COG4287@2|Bacteria,1NP5V@1224|Proteobacteria	1224|Proteobacteria	O	PhoPQ-activated pathogenicity-related protein	pqaA	-	-	-	-	-	-	-	-	-	-	-	PhoPQ_related
TLS2_k127_7319122_1	204669.Acid345_2940	1.26e-114	384.0	COG2234@1|root,COG2234@2|Bacteria,3Y3SC@57723|Acidobacteria,2JIVJ@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_7320925_2	886293.Sinac_7309	2.592e-64	226.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
TLS2_k127_7320925_0	1195236.CTER_0131	1.909e-146	475.0	COG0637@1|root,COG0637@2|Bacteria,1VSTY@1239|Firmicutes,24D2J@186801|Clostridia	186801|Clostridia	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS2_k127_7320925_1	1297742.A176_02984	7.969e-91	304.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,42PC4@68525|delta/epsilon subdivisions,2WMG6@28221|Deltaproteobacteria,2YXXU@29|Myxococcales	28221|Deltaproteobacteria	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodB	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
TLS2_k127_7320925_3	203122.Sde_0642	4.221e-31	132.0	COG0659@1|root,COG0659@2|Bacteria	2|Bacteria	P	secondary active sulfate transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	NACHT
TLS2_k127_7320925_4	1267535.KB906767_gene1210	1.346e-10	69.0	COG4932@1|root,COG4932@2|Bacteria,3Y3KQ@57723|Acidobacteria,2JMAN@204432|Acidobacteriia	57723|Acidobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
TLS2_k127_7322287_5	1265505.ATUG01000001_gene4505	8.676e-16	81.0	COG0509@1|root,COG0509@2|Bacteria,1RC80@1224|Proteobacteria,42R79@68525|delta/epsilon subdivisions,2WN04@28221|Deltaproteobacteria,2MJJZ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Glycine cleavage H-protein	-	-	-	-	-	-	-	-	-	-	-	-	GCV_H
TLS2_k127_7322287_4	1089553.Tph_c26700	3.22e-45	166.0	COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia,42GKF@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
TLS2_k127_7322287_1	1267535.KB906767_gene5432	2.784e-81	280.0	COG0414@1|root,COG0414@2|Bacteria,3Y40A@57723|Acidobacteria,2JHS1@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
TLS2_k127_7322287_0	1267535.KB906767_gene5433	4.307e-100	334.0	COG0413@1|root,COG0413@2|Bacteria,3Y3GX@57723|Acidobacteria,2JI6Y@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TLS2_k127_7322287_3	1267535.KB906767_gene5434	2.998e-47	181.0	COG5495@1|root,COG5495@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF2520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
TLS2_k127_7322287_2	204669.Acid345_4483	7.621e-50	197.0	COG4206@1|root,COG4206@2|Bacteria,3Y42S@57723|Acidobacteria,2JHUU@204432|Acidobacteriia	204432|Acidobacteriia	H	TonB-dependent Receptor Plug Domain	-	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_7322406_2	880072.Desac_0216	2.747e-170	544.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,42MKI@68525|delta/epsilon subdivisions,2WIQJ@28221|Deltaproteobacteria,2MR2P@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	alpha amylase, catalytic	treZ	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
TLS2_k127_7322406_0	1382356.JQMP01000004_gene488	6.996e-321	993.0	COG0296@1|root,COG0296@2|Bacteria,2G5IR@200795|Chloroflexi,27XZS@189775|Thermomicrobia	189775|Thermomicrobia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TLS2_k127_7322406_1	479434.Sthe_1092	1.196e-286	900.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia	189775|Thermomicrobia	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
TLS2_k127_7324487_3	886293.Sinac_2714	1.258e-115	386.0	COG0673@1|root,COG0673@2|Bacteria,2IXFW@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_7324487_7	118168.MC7420_7073	1.003e-37	149.0	COG2340@1|root,COG2340@2|Bacteria,1G6I4@1117|Cyanobacteria,1HBFT@1150|Oscillatoriales	1117|Cyanobacteria	S	protein with SCP PR1 domains	-	-	-	-	-	-	-	-	-	-	-	-	CAP
TLS2_k127_7324487_2	756272.Plabr_1421	1.669e-121	401.0	COG0530@1|root,COG0530@2|Bacteria,2IZ8S@203682|Planctomycetes	203682|Planctomycetes	P	COG0530 Ca2 Na antiporter	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
TLS2_k127_7324487_5	1267534.KB906757_gene1028	7.659e-64	233.0	COG0667@1|root,COG0667@2|Bacteria,3Y3TE@57723|Acidobacteria	57723|Acidobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_7324487_0	886293.Sinac_1268	3.696e-274	864.0	COG1554@1|root,COG1554@2|Bacteria	2|Bacteria	G	hydrolase, family 65, central catalytic	-	-	3.2.1.51	ko:K15923	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	GH95	-	Glyco_hyd_65N_2
TLS2_k127_7324487_1	1307759.JOMJ01000004_gene2463	8.411e-181	581.0	COG4885@1|root,COG4885@2|Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
TLS2_k127_7324487_4	1267535.KB906767_gene1576	2.093e-109	368.0	COG2010@1|root,COG2010@2|Bacteria,3Y7CN@57723|Acidobacteria,2JK7I@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS2_k127_7324487_6	1267535.KB906767_gene1418	4.265e-49	184.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214
TLS2_k127_7324487_8	477641.MODMU_1338	1.883e-14	80.0	COG2208@1|root,COG2208@2|Bacteria,2GKEF@201174|Actinobacteria,4EUQ1@85013|Frankiales	201174|Actinobacteria	T	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,PAS_3,PAS_4,SpoIIE
TLS2_k127_7325993_2	1121017.AUFG01000010_gene1631	6.735e-05	46.0	COG3850@1|root,COG3850@2|Bacteria,2HY2J@201174|Actinobacteria,4FJI8@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase-like ATPases	-	-	2.7.13.3	ko:K07673	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c
TLS2_k127_7325993_1	402777.KB235906_gene304	2.77e-27	123.0	COG3039@1|root,COG3039@2|Bacteria,1G3IA@1117|Cyanobacteria,1HEFE@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
TLS2_k127_7325993_0	290397.Adeh_0912	2.191e-149	488.0	COG2132@1|root,COG4733@1|root,COG2132@2|Bacteria,COG4733@2|Bacteria,1R9AF@1224|Proteobacteria,42YQG@68525|delta/epsilon subdivisions,2WTP2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Multicopper oxidase	ompB	-	-	-	-	-	-	-	-	-	-	-	ASH,Cu-oxidase_2
TLS2_k127_7326827_1	797209.ZOD2009_15151	9.001e-08	62.0	COG0500@1|root,arCOG01402@2157|Archaea,2XYWP@28890|Euryarchaeota,23WPJ@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
TLS2_k127_7326827_0	234267.Acid_7266	1.135e-55	211.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
TLS2_k127_7344339_4	221288.JH992901_gene3725	2.283e-39	148.0	COG1619@1|root,COG1619@2|Bacteria,1G059@1117|Cyanobacteria,1JH9P@1189|Stigonemataceae	1117|Cyanobacteria	V	LD-carboxypeptidase	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
TLS2_k127_7344339_0	234267.Acid_5905	4.641e-71	252.0	COG1082@1|root,COG1082@2|Bacteria,3Y7EJ@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_7344339_3	204669.Acid345_2119	6.04e-47	177.0	COG0727@1|root,COG0727@2|Bacteria,3Y4VW@57723|Acidobacteria,2JJKG@204432|Acidobacteriia	204432|Acidobacteriia	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
TLS2_k127_7344339_1	1123368.AUIS01000009_gene2443	3.77e-66	233.0	COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,1S4C3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the LOG family	yvdD	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TLS2_k127_7344339_2	1397527.Q670_13900	1.652e-56	200.0	COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,1RMNH@1236|Gammaproteobacteria,1XHAB@135619|Oceanospirillales	135619|Oceanospirillales	K	accessory protein	-	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
TLS2_k127_7349672_5	309801.trd_0110	1.241e-79	275.0	COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi,27XKF@189775|Thermomicrobia	189775|Thermomicrobia	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
TLS2_k127_7349672_6	234267.Acid_6082	4.136e-55	199.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	rapK	GO:0003674,GO:0003824,GO:0016787,GO:0016801,GO:0016803	3.3.2.13,4.1.3.40,4.1.3.45	ko:K18239,ko:K18240	ko00130,ko00400,ko01100,ko01110,map00130,map00400,map01100,map01110	M00117	R01302,R10583,R10597	RC00350,RC00491,RC02148,RC03212	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribonuc_L-PSP
TLS2_k127_7349672_7	1122931.AUAE01000008_gene4075	3.417e-36	158.0	COG0823@1|root,COG0823@2|Bacteria,4NIGD@976|Bacteroidetes,2G2P7@200643|Bacteroidia,22ZI1@171551|Porphyromonadaceae	976|Bacteroidetes	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7349672_1	452637.Oter_2951	8.827e-196	629.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
TLS2_k127_7349672_0	335543.Sfum_1622	2.3e-310	977.0	COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1R7E0@1224|Proteobacteria,42XD8@68525|delta/epsilon subdivisions,2WT8U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_C554
TLS2_k127_7349672_3	452637.Oter_2949	1.408e-173	554.0	COG3292@1|root,COG3292@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
TLS2_k127_7349672_2	452637.Oter_2948	2.982e-186	594.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_7349672_4	452637.Oter_2947	8.634e-80	281.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_7349672_8	987059.RBXJA2T_15543	1.778e-10	73.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,1KJG2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
TLS2_k127_7361474_1	1267533.KB906736_gene870	5.137e-30	134.0	COG0457@1|root,COG0457@2|Bacteria,3Y3JH@57723|Acidobacteria,2JI8K@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
TLS2_k127_7361474_0	247490.KSU1_D0287	2.541e-62	223.0	COG1216@1|root,COG1216@2|Bacteria,2IZV9@203682|Planctomycetes	203682|Planctomycetes	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_7361474_2	765911.Thivi_2481	2.014e-20	101.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RZRG@1236|Gammaproteobacteria,1WVXI@135613|Chromatiales	135613|Chromatiales	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_7365329_1	204669.Acid345_2692	4.62e-14	85.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7365329_0	261292.Nit79A3_2905	3.818e-175	568.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,372GH@32003|Nitrosomonadales	28216|Betaproteobacteria	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
TLS2_k127_7365329_2	382464.ABSI01000011_gene2585	1.466e-07	53.0	COG3039@1|root,COG3039@2|Bacteria,46WXW@74201|Verrucomicrobia,2IWQD@203494|Verrucomicrobiae	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
TLS2_k127_7368812_1	234267.Acid_5861	1.605e-56	199.0	COG1734@1|root,COG1734@2|Bacteria,3Y85W@57723|Acidobacteria	57723|Acidobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
TLS2_k127_7368812_3	391612.CY0110_07334	3.271e-19	89.0	COG2442@1|root,COG2442@2|Bacteria,1G869@1117|Cyanobacteria,3KIU5@43988|Cyanothece	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
TLS2_k127_7368812_4	76114.p2A227	2.33e-15	77.0	COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2VICA@28216|Betaproteobacteria,2M00E@206389|Rhodocyclales	206389|Rhodocyclales	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_7368812_2	85643.Tmz1t_0371	1.864e-23	109.0	COG0582@1|root,COG0582@2|Bacteria,1NX90@1224|Proteobacteria,2VJRU@28216|Betaproteobacteria,2KXTA@206389|Rhodocyclales	206389|Rhodocyclales	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_7368812_5	204669.Acid345_2695	2.068e-11	67.0	2C7DG@1|root,2ZTXV@2|Bacteria,3Y94Z@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7368812_0	1340493.JNIF01000003_gene2985	7.82e-74	256.0	COG0204@1|root,COG0204@2|Bacteria,3Y4EM@57723|Acidobacteria	57723|Acidobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_737297_0	1279017.AQYJ01000024_gene1001	2.512e-114	386.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S41,TPR_8,Tricorn_C1
TLS2_k127_737297_1	234267.Acid_4012	3.988e-20	92.0	COG3525@1|root,COG3525@2|Bacteria	2|Bacteria	G	beta-N-acetylhexosaminidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7405382_1	96561.Dole_0151	3.146e-05	52.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2MI5B@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_7405382_0	234267.Acid_0387	3.636e-107	359.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
TLS2_k127_7430867_1	404589.Anae109_2620	3.883e-119	399.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Y98@68525|delta/epsilon subdivisions,2WTXU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_7430867_0	682795.AciX8_1492	1.973e-125	430.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,3Y2V7@57723|Acidobacteria,2JIYH@204432|Acidobacteriia	57723|Acidobacteria	D	G-rich domain on putative tyrosine kinase	-	-	2.7.10.1	ko:K08252,ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,Wzz
TLS2_k127_7439082_4	234267.Acid_1817	9.419e-138	452.0	COG4206@1|root,COG4206@2|Bacteria,3Y8AK@57723|Acidobacteria	57723|Acidobacteria	H	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
TLS2_k127_7439082_5	1385935.N836_31865	2.426e-124	407.0	COG2423@1|root,COG2423@2|Bacteria	2|Bacteria	E	ornithine cyclodeaminase activity	tubZ	-	4.3.1.12,4.3.1.28	ko:K01750,ko:K20500	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
TLS2_k127_7439082_6	1174528.JH992893_gene5895	7.068e-58	210.0	COG2091@1|root,COG2091@2|Bacteria,1G5GA@1117|Cyanobacteria,1JH83@1189|Stigonemataceae	1117|Cyanobacteria	H	4'-phosphopantetheinyl transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_7439082_3	102129.Lepto7375DRAFT_8116	1.067e-167	534.0	COG1960@1|root,COG1960@2|Bacteria,1G4K8@1117|Cyanobacteria,1HE4R@1150|Oscillatoriales	1117|Cyanobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_7439082_2	1385935.N836_31875	7.163e-179	575.0	COG1020@1|root,COG1020@2|Bacteria,1GQ70@1117|Cyanobacteria,1HETZ@1150|Oscillatoriales	1117|Cyanobacteria	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
TLS2_k127_7439082_0	102129.Lepto7375DRAFT_8119	0.0	1314.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria	1117|Cyanobacteria	Q	Amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
TLS2_k127_7439082_1	1385935.N836_31890	1.494e-263	844.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HADK@1150|Oscillatoriales	1117|Cyanobacteria	Q	Amino acid adenylation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,TauD
TLS2_k127_7448485_4	1184267.A11Q_2587	1.012e-09	70.0	2DIDK@1|root,302WD@2|Bacteria,1P7I4@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7448485_3	1191523.MROS_1643	3.301e-14	73.0	2EGPU@1|root,33AFZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7448485_1	1254432.SCE1572_19905	1.162e-59	219.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,43C9H@68525|delta/epsilon subdivisions,2X5ZH@28221|Deltaproteobacteria,2YW36@29|Myxococcales	28221|Deltaproteobacteria	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_7448485_2	648885.KB316284_gene4659	1.036e-46	173.0	COG2323@1|root,COG2323@2|Bacteria,1QMVA@1224|Proteobacteria,2VBHB@28211|Alphaproteobacteria,1JYWA@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
TLS2_k127_7448485_0	65393.PCC7424_1901	2.658e-93	323.0	COG4325@1|root,COG4325@2|Bacteria,1G2Y0@1117|Cyanobacteria	1117|Cyanobacteria	S	membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
TLS2_k127_7454582_0	671143.DAMO_0850	1.545e-204	650.0	COG0557@1|root,COG0557@2|Bacteria,2NNV2@2323|unclassified Bacteria	2|Bacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnb	-	3.1.13.1	ko:K01147,ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
TLS2_k127_7454582_2	1174528.JH992893_gene5681	1.056e-34	133.0	COG3251@1|root,COG3251@2|Bacteria,1G9G8@1117|Cyanobacteria	1117|Cyanobacteria	S	MbtH-like protein	-	-	-	ko:K05375	ko00261,ko01130,map00261,map01130	M00736	R10880	RC00064,RC00141,RC03296,RC03297,RC03298	ko00000,ko00001,ko00002	-	-	-	MbtH
TLS2_k127_7454582_1	56107.Cylst_3960	7.001e-114	379.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HR5M@1161|Nostocales	1117|Cyanobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
TLS2_k127_7469825_1	671143.DAMO_2934	1.28e-77	264.0	COG0667@1|root,COG0667@2|Bacteria,2NS4R@2323|unclassified Bacteria	2|Bacteria	C	Aldo/keto reductase family	ydjG	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_7469825_0	382464.ABSI01000005_gene1011	2.424e-140	462.0	COG1219@1|root,COG1219@2|Bacteria,46U7E@74201|Verrucomicrobia,2IVDM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
TLS2_k127_7469825_2	518766.Rmar_0609	0.0004736	50.0	2FFT5@1|root,347QA@2|Bacteria,4P5W2@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4398
TLS2_k127_748398_2	682795.AciX8_1687	4.623e-25	108.0	COG0482@1|root,COG0482@2|Bacteria,3Y2JX@57723|Acidobacteria,2JHKV@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TLS2_k127_748398_0	1144275.COCOR_02677	4.24e-74	263.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2WJFA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
TLS2_k127_748398_1	234267.Acid_0772	2.421e-57	220.0	COG0308@1|root,COG0457@1|root,COG0308@2|Bacteria,COG0457@2|Bacteria,3Y3C5@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1,TPR_11,TPR_16
TLS2_k127_772853_7	204669.Acid345_4483	8.89e-09	58.0	COG4206@1|root,COG4206@2|Bacteria,3Y42S@57723|Acidobacteria,2JHUU@204432|Acidobacteriia	204432|Acidobacteriia	H	TonB-dependent Receptor Plug Domain	-	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS2_k127_772853_5	555079.Toce_1426	6.435e-45	175.0	COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,24AKE@186801|Clostridia,42FIR@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS2_k127_772853_2	656519.Halsa_1986	2.375e-68	244.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,3WAHZ@53433|Halanaerobiales	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
TLS2_k127_772853_4	574087.Acear_0770	2.917e-64	230.0	COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,3WAET@53433|Halanaerobiales	186801|Clostridia	HP	PFAM ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
TLS2_k127_772853_8	880072.Desac_2220	2.126e-05	57.0	2FC3U@1|root,3447T@2|Bacteria,1P1JE@1224|Proteobacteria,4321B@68525|delta/epsilon subdivisions,2WWC9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_772853_0	504472.Slin_4997	4.113e-108	364.0	COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,47K7H@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_772853_6	234267.Acid_0845	7.176e-16	93.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	cpeZ	-	-	ko:K05384,ko:K05386	ko00196,ko01100,map00196,map01100	-	-	-	ko00000,ko00001,ko00194	-	-	-	HEAT_2
TLS2_k127_772853_1	886293.Sinac_5667	2.858e-97	355.0	COG2133@1|root,COG2133@2|Bacteria,2IZH6@203682|Planctomycetes	203682|Planctomycetes	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
TLS2_k127_772853_3	234267.Acid_7179	6.466e-68	235.0	COG2077@1|root,COG2077@2|Bacteria,3Y5DK@57723|Acidobacteria	57723|Acidobacteria	O	Redoxin	-	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
TLS2_k127_775075_1	1429046.RR21198_0308	3.868e-35	143.0	COG0463@1|root,COG1215@1|root,COG0463@2|Bacteria,COG1215@2|Bacteria,2IMWN@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_775075_0	234267.Acid_5083	2.223e-48	196.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	234267.Acid_5083|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_787717_1	641491.DND132_1483	1.935e-103	348.0	COG0438@1|root,COG0438@2|Bacteria,1N1RZ@1224|Proteobacteria,42UHY@68525|delta/epsilon subdivisions,2WQD7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_787717_0	1158606.I579_01779	2.175e-114	379.0	COG1215@1|root,COG1215@2|Bacteria,1TPBB@1239|Firmicutes,4HAAE@91061|Bacilli,4AZCA@81852|Enterococcaceae	91061|Bacilli	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_787717_2	861299.J421_6044	2.249e-101	334.0	COG2192@1|root,COG2192@2|Bacteria,1ZUTI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TLS2_k127_792927_1	335543.Sfum_3264	2.349e-81	277.0	COG0574@1|root,COG0574@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2MR7X@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
TLS2_k127_792927_0	525904.Tter_0805	2.297e-168	538.0	COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS2_k127_799939_1	1541065.JRFE01000012_gene2438	2.494e-80	288.0	COG2303@1|root,COG2303@2|Bacteria,1G2KW@1117|Cyanobacteria,3VMJ0@52604|Pleurocapsales	1117|Cyanobacteria	E	COGs COG2303 Choline dehydrogenase and related flavoprotein	-	-	-	-	-	-	-	-	-	-	-	-	DAO,GMC_oxred_C
TLS2_k127_799939_0	986075.CathTA2_1874	1.984e-155	502.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,4H9T4@91061|Bacilli	91061|Bacilli	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TLS2_k127_799939_5	1304880.JAGB01000001_gene41	2.996e-22	99.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TLS2_k127_799939_3	1121441.AUCX01000010_gene255	9.166e-28	115.0	COG1837@1|root,COG1837@2|Bacteria,1N7IX@1224|Proteobacteria,42TXI@68525|delta/epsilon subdivisions,2WQBS@28221|Deltaproteobacteria,2MCGN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the UPF0109 family	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
TLS2_k127_799939_4	1267533.KB906735_gene4712	8.489e-25	109.0	COG0806@1|root,COG0806@2|Bacteria,3Y51G@57723|Acidobacteria,2JJGA@204432|Acidobacteriia	204432|Acidobacteriia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
TLS2_k127_799939_2	1449063.JMLS01000018_gene5861	1.423e-76	262.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,26RCU@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
TLS2_k127_800093_0	1382359.JIAL01000001_gene1316	6.596e-167	551.0	COG0457@1|root,COG0457@2|Bacteria,3Y2IK@57723|Acidobacteria,2JKNM@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8,UnbV_ASPIC,VCBS
TLS2_k127_800093_1	398512.JQKC01000006_gene725	1.727e-148	479.0	COG0667@1|root,COG0667@2|Bacteria,1TRS0@1239|Firmicutes,247RJ@186801|Clostridia,3WGK0@541000|Ruminococcaceae	186801|Clostridia	C	aldo keto reductase	-	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
TLS2_k127_816795_6	204669.Acid345_1569	7.848e-12	70.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria,2JP4Y@204432|Acidobacteriia	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
TLS2_k127_816795_3	247490.KSU1_C1426	7.033e-92	315.0	COG0042@1|root,COG0042@2|Bacteria,2IYI5@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
TLS2_k127_816795_0	338966.Ppro_2790	7.667e-238	753.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	nuoG-1	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3349	Fer2_4,Fer4_10,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
TLS2_k127_816795_1	338966.Ppro_2789	2.259e-144	469.0	COG1150@1|root,COG1150@2|Bacteria,1QWNB@1224|Proteobacteria,43BTA@68525|delta/epsilon subdivisions,2X741@28221|Deltaproteobacteria,43VYT@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
TLS2_k127_816795_2	338966.Ppro_2788	6.086e-113	374.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WKKC@28221|Deltaproteobacteria,43UVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	hdrF	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
TLS2_k127_816795_5	338966.Ppro_2796	3.435e-37	145.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	-	-	3.4.23.51	ko:K00442,ko:K08315	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000,ko01002	-	-	-	HycI
TLS2_k127_816795_4	338966.Ppro_2787	4.928e-39	154.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,42NFV@68525|delta/epsilon subdivisions,2WJZ0@28221|Deltaproteobacteria,43T2H@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
TLS2_k127_817104_8	555779.Dthio_PD0754	2.048e-13	71.0	2AFHA@1|root,315HT@2|Bacteria,1N31Y@1224|Proteobacteria,43DNR@68525|delta/epsilon subdivisions,2X6MU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
TLS2_k127_817104_0	861299.J421_2390	6.518e-110	366.0	COG0604@1|root,COG0604@2|Bacteria,1ZT6R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_817104_6	234267.Acid_2715	1.692e-31	137.0	COG1988@1|root,COG1988@2|Bacteria,3Y305@57723|Acidobacteria	57723|Acidobacteria	S	membrane-bound metal-dependent hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
TLS2_k127_817104_3	1267533.KB906734_gene3884	2.542e-84	291.0	COG2025@1|root,COG2025@2|Bacteria,3Y3JE@57723|Acidobacteria,2JM9U@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein FAD-binding domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TLS2_k127_817104_4	1267533.KB906734_gene3885	2.315e-70	246.0	COG2086@1|root,COG2086@2|Bacteria,3Y2PD@57723|Acidobacteria,2JK7K@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
TLS2_k127_817104_1	234267.Acid_1230	5.463e-93	310.0	COG0235@1|root,COG0235@2|Bacteria,3Y3W2@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Class II aldolase	-	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
TLS2_k127_817104_2	234267.Acid_5438	1.526e-87	299.0	COG1462@1|root,COG1462@2|Bacteria,3Y3KF@57723|Acidobacteria	57723|Acidobacteria	M	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
TLS2_k127_817104_9	926566.Terro_3666	2.284e-06	57.0	2F5TK@1|root,33YCF@2|Bacteria,3Y7TG@57723|Acidobacteria,2JMXH@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_817104_5	1267535.KB906767_gene3573	2.99e-42	166.0	COG0329@1|root,COG0329@2|Bacteria	1267535.KB906767_gene3573|-	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_832686_0	1232410.KI421418_gene2241	1.105e-78	272.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,42NDF@68525|delta/epsilon subdivisions,2WJPS@28221|Deltaproteobacteria,43TE5@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS2_k127_832686_1	313612.L8106_11582	1.635e-66	237.0	COG1216@1|root,COG1216@2|Bacteria,1G2MT@1117|Cyanobacteria,1H8YG@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
TLS2_k127_832686_2	1142394.PSMK_19720	1.135e-35	148.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_83909_0	880073.Calab_3278	2.343e-60	226.0	COG3049@1|root,COG3049@2|Bacteria	2|Bacteria	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CBAH
TLS2_k127_846503_3	886293.Sinac_1729	2.672e-143	466.0	COG0501@1|root,COG0501@2|Bacteria,2J0GY@203682|Planctomycetes	203682|Planctomycetes	O	CAAX prenyl protease N-terminal, five membrane helices	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,Peptidase_M48_N
TLS2_k127_846503_2	177437.HRM2_48490	2.345e-145	478.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2MJIJ@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS2_k127_846503_4	414684.RC1_3885	1.26e-79	284.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TT21@28211|Alphaproteobacteria,2JWHK@204441|Rhodospirillales	204441|Rhodospirillales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
TLS2_k127_846503_0	335283.Neut_1947	0.0	1069.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,3727K@32003|Nitrosomonadales	28216|Betaproteobacteria	V	Hydrophobe amphiphile efflux-1 HAE1	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
TLS2_k127_846503_1	1267534.KB906757_gene1068	1.562e-254	803.0	COG1874@1|root,COG1874@2|Bacteria,3Y65E@57723|Acidobacteria,2JKUI@204432|Acidobacteriia	204432|Acidobacteriia	G	Beta-galactosidase trimerisation domain	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42M
TLS2_k127_863344_3	1313172.YM304_14560	1.2e-37	155.0	COG0438@1|root,COG0438@2|Bacteria,2GQ6S@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
TLS2_k127_863344_2	251229.Chro_0710	1.069e-53	218.0	COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1GCKB@1117|Cyanobacteria	1117|Cyanobacteria	Q	COGs COG3319 Thioesterase domains of type I polyketide synthase or non-ribosomal peptide synthetase	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding,Thioesterase
TLS2_k127_863344_0	63737.Npun_R3026	1.294e-257	848.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
TLS2_k127_863344_1	1178825.ALIH01000006_gene1470	5.067e-85	290.0	COG2890@1|root,COG2890@2|Bacteria	2|Bacteria	J	protein-(glutamine-N5) methyltransferase activity	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyTransf_Reg,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
TLS2_k127_865649_1	204669.Acid345_0621	6.028e-155	514.0	COG0612@1|root,COG0612@2|Bacteria,3Y322@57723|Acidobacteria,2JP25@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16_C
TLS2_k127_865649_0	639030.JHVA01000001_gene3842	1.06e-169	549.0	COG0612@1|root,COG0612@2|Bacteria,3Y3XF@57723|Acidobacteria,2JHR4@204432|Acidobacteriia	204432|Acidobacteriia	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_868374_1	1191523.MROS_0115	9.826e-154	500.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K03292,ko:K16248	-	-	-	-	ko00000,ko02000	2.A.2	-	-	MFS_2,MFS_3
TLS2_k127_868374_0	761193.Runsl_2857	2.031e-196	624.0	COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,47JYR@768503|Cytophagia	976|Bacteroidetes	P	PFAM sulfatase	mdsA	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_868374_2	497964.CfE428DRAFT_6049	1.054e-153	499.0	COG0673@1|root,COG0673@2|Bacteria,46U0A@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_872584_1	797303.Natpe_3987	6.039e-23	104.0	COG1672@1|root,arCOG03166@2157|Archaea,2XTP2@28890|Euryarchaeota,23TEI@183963|Halobacteria	183963|Halobacteria	S	ATPase (AAA superfamily)	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	ATPase_2,DUF234
TLS2_k127_872584_2	1144275.COCOR_06888	8.203e-05	51.0	2E2IR@1|root,32XNB@2|Bacteria,1N3QT@1224|Proteobacteria,43EDU@68525|delta/epsilon subdivisions,2X831@28221|Deltaproteobacteria,2Z193@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_872584_0	1071679.BG57_08010	8.831e-27	128.0	COG2909@1|root,COG4995@1|root,COG2909@2|Bacteria,COG4995@2|Bacteria,1QUP3@1224|Proteobacteria,2VM2I@28216|Betaproteobacteria,1K6DW@119060|Burkholderiaceae	28216|Betaproteobacteria	K	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_16
TLS2_k127_885159_2	518766.Rmar_2204	2.512e-57	207.0	COG1024@1|root,COG1024@2|Bacteria,4NHRF@976|Bacteroidetes,1FJQZ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS2_k127_885159_3	1122222.AXWR01000011_gene849	1.814e-44	168.0	COG2151@1|root,COG2151@2|Bacteria,1WJW0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	TIGRFAM phenylacetate-CoA oxygenase, PaaJ subunit	paaD	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
TLS2_k127_885159_1	649638.Trad_1147	2.901e-83	284.0	COG3396@1|root,COG3396@2|Bacteria,1WI5D@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	TIGRFAM Phenylacetate-CoA oxygenase, PaaI subunit	paaC	-	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
TLS2_k127_885159_4	1122223.KB890698_gene787	2.11e-34	139.0	COG3460@1|root,COG3460@2|Bacteria,1WIFI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	phenylacetic acid degradation	paaB	-	-	ko:K02610	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	PaaB
TLS2_k127_885159_0	518766.Rmar_1543	1.75e-100	330.0	COG3396@1|root,COG3396@2|Bacteria,4NFJN@976|Bacteroidetes	976|Bacteroidetes	Q	With PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
TLS2_k127_886217_4	1449063.JMLS01000022_gene6542	4.924e-51	190.0	2DBAY@1|root,2Z84S@2|Bacteria,1UJ57@1239|Firmicutes,4IT21@91061|Bacilli,2777U@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DUF1835)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1835
TLS2_k127_886217_0	880073.Calab_1812	4.121e-150	485.0	COG4948@1|root,COG4948@2|Bacteria,2NP34@2323|unclassified Bacteria	2|Bacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	ykfB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564	4.2.1.113,5.1.1.20	ko:K02549,ko:K19802	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031,R10938	RC01053,RC03309	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_886217_2	880073.Calab_1813	2.03e-70	256.0	COG0791@1|root,COG0791@2|Bacteria,2NREJ@2323|unclassified Bacteria	2|Bacteria	M	NlpC/P60 family	ykfC	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,SH3_3
TLS2_k127_886217_3	697281.Mahau_1084	1.532e-57	208.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
TLS2_k127_886217_1	1123248.KB893381_gene971	5.542e-134	440.0	COG0673@1|root,COG0673@2|Bacteria,4P1NH@976|Bacteroidetes	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_886217_5	1235835.C814_02390	1.232e-06	50.0	COG0328@1|root,COG0328@2|Bacteria,1V4A0@1239|Firmicutes,24FSS@186801|Clostridia,3WISH@541000|Ruminococcaceae	186801|Clostridia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
TLS2_k127_896110_0	1379698.RBG1_1C00001G0471	3.904e-195	617.0	COG1012@1|root,COG1012@2|Bacteria,2NNR8@2323|unclassified Bacteria	2|Bacteria	C	Belongs to the aldehyde dehydrogenase family	ycbD	-	1.2.1.3	ko:K00128,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_896110_1	405948.SACE_3649	4.385e-94	321.0	COG0859@1|root,COG0859@2|Bacteria,2IB6V@201174|Actinobacteria,4DXR3@85010|Pseudonocardiales	201174|Actinobacteria	M	PFAM glycosyl transferase family 9	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_901437_0	234267.Acid_1992	3.423e-214	684.0	COG1680@1|root,COG1680@2|Bacteria,3Y8A8@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_901437_1	472759.Nhal_3311	2.31e-182	587.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,1X0QS@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD dependent oxidoreductase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TLS2_k127_901437_2	1188252.AJYK01000120_gene1001	2.028e-09	63.0	COG0438@1|root,COG0438@2|Bacteria,1R7VT@1224|Proteobacteria,1SYK1@1236|Gammaproteobacteria,1Y2U5@135623|Vibrionales	135623|Vibrionales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
TLS2_k127_90346_0	1121918.ARWE01000001_gene1621	4.757e-265	824.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,43S4A@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
TLS2_k127_90346_1	443143.GM18_1676	9.563e-191	605.0	COG2199@1|root,COG5002@1|root,COG2199@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CSV@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_4,PAS_9
TLS2_k127_90346_4	933262.AXAM01000121_gene9	3.469e-08	55.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
TLS2_k127_90346_3	269799.Gmet_0424	5.275e-32	127.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4316,YodL
TLS2_k127_90346_2	1125863.JAFN01000001_gene1408	1.161e-127	413.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WKS0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_906211_0	1121943.KB900000_gene1205	2.868e-74	259.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XHGI@135619|Oceanospirillales	135619|Oceanospirillales	P	cation transport ATPase	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS2_k127_922105_0	1293054.HSACCH_01314	9.63e-113	376.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,3WA6H@53433|Halanaerobiales	186801|Clostridia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS2_k127_922105_2	557598.LHK_00755	2.408e-40	158.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2VKFN@28216|Betaproteobacteria,2KRK4@206351|Neisseriales	206351|Neisseriales	M	Transglycosylase SLT domain	slt	-	3.2.1.17	ko:K01185	-	-	-	-	ko00000,ko01000	-	-	-	DUF4124,SLT
TLS2_k127_922105_1	204669.Acid345_1153	7.132e-109	374.0	COG0860@1|root,COG0860@2|Bacteria,3Y3M0@57723|Acidobacteria,2JI9V@204432|Acidobacteriia	204432|Acidobacteriia	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
TLS2_k127_981546_2	1382359.JIAL01000001_gene843	2.158e-17	87.0	COG1314@1|root,COG1314@2|Bacteria,3Y56S@57723|Acidobacteria,2JJVA@204432|Acidobacteriia	204432|Acidobacteriia	U	Preprotein translocase SecG subunit	-	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
TLS2_k127_981546_1	234267.Acid_6502	5.145e-88	297.0	COG0149@1|root,COG0149@2|Bacteria,3Y2YS@57723|Acidobacteria	57723|Acidobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TLS2_k127_981546_0	945713.IALB_1271	2.051e-126	412.0	COG0126@1|root,COG0126@2|Bacteria	2|Bacteria	F	phosphoglycerate kinase activity	pgk	GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
TLS2_k127_994214_0	382464.ABSI01000009_gene3989	2.589e-152	500.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	BAAT_C,Hydrolase_4
TLS2_k127_994214_2	373994.Riv7116_4018	1.133e-123	408.0	COG2382@1|root,COG2382@2|Bacteria,1G24A@1117|Cyanobacteria	1117|Cyanobacteria	P	esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase
TLS2_k127_994214_1	497964.CfE428DRAFT_2129	9.668e-149	479.0	COG0841@1|root,COG0841@2|Bacteria,46SDW@74201|Verrucomicrobia	74201|Verrucomicrobia	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
TLS2_k127_994557_1	584708.Apau_1725	1.525e-96	344.0	COG4191@1|root,COG4191@2|Bacteria,3TBCP@508458|Synergistetes	2|Bacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
TLS2_k127_994557_0	1121904.ARBP01000010_gene2227	6.669e-138	452.0	2DBQR@1|root,2ZAG2@2|Bacteria,4NK84@976|Bacteroidetes,47NS0@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2
TLS2_k127_994557_4	1121939.L861_10650	2.846e-42	158.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,1S9NT@1236|Gammaproteobacteria,1XQ3Q@135619|Oceanospirillales	135619|Oceanospirillales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_994557_3	1278073.MYSTI_07011	1.241e-62	219.0	COG3832@1|root,COG3832@2|Bacteria,1RHJJ@1224|Proteobacteria	1224|Proteobacteria	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_994557_2	1235803.C825_01882	8.63e-92	318.0	COG5434@1|root,COG5434@2|Bacteria,4NIEA@976|Bacteroidetes,2FMVC@200643|Bacteroidia	976|Bacteroidetes	M	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
TLS2_k127_999280_0	264732.Moth_1811	4.595e-159	515.0	COG3280@1|root,COG3280@2|Bacteria,1UERK@1239|Firmicutes,25JR7@186801|Clostridia,42HXY@68295|Thermoanaerobacterales	186801|Clostridia	G	Alpha amylase, catalytic domain	-	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
## 3974 queries scanned
## Total time (seconds): 82.65462613105774
## Rate: 48.08 q/s