## Thu Feb 19 18:30:42 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/TLS2_bin.46.fa -m mmseqs --output TLS2_bin.46 --output_dir /data/result/bins/wyx/eggqs50+/TLS2_bin.46 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TLS2_k127_1017924_5	1267005.KB911259_gene3834	2.339e-97	320.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,3N67Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
TLS2_k127_1017924_7	1385935.N836_05480	5.913e-68	235.0	COG1670@1|root,COG1670@2|Bacteria,1G59B@1117|Cyanobacteria,1HE96@1150|Oscillatoriales	1117|Cyanobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.82	ko:K00663	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Acetyltransf_8
TLS2_k127_1017924_13	1267005.KB911256_gene1892	1.155e-31	134.0	COG1266@1|root,COG1266@2|Bacteria,1N230@1224|Proteobacteria	1224|Proteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_1017924_10	1267005.KB911256_gene1893	1.551e-52	196.0	COG3814@1|root,COG3814@2|Bacteria,1N1FE@1224|Proteobacteria,2U7H9@28211|Alphaproteobacteria,3N6YU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Stringent starvation protein B	MA20_02250	-	-	ko:K09985	-	-	-	-	ko00000	-	-	-	SspB
TLS2_k127_1017924_8	1121106.JQKB01000016_gene5340	8.351e-68	244.0	COG1028@1|root,COG1028@2|Bacteria,1NCD3@1224|Proteobacteria,2TTFD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_1017924_6	582899.Hden_2519	4.661e-78	268.0	COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,2U1NG@28211|Alphaproteobacteria,3N9AE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Class II Aldolase and Adducin N-terminal domain	fucA	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
TLS2_k127_1017924_4	414684.RC1_0589	1.035e-104	353.0	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2TS4B@28211|Alphaproteobacteria,2JQ6A@204441|Rhodospirillales	204441|Rhodospirillales	S	cobalamin synthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
TLS2_k127_1017924_12	717785.HYPMC_1278	1.614e-46	173.0	COG0454@1|root,COG0456@2|Bacteria,1MZUT@1224|Proteobacteria,2UC9I@28211|Alphaproteobacteria,3N9CP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	MA20_05250	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_1017924_1	1267005.KB911255_gene2440	1.861e-197	633.0	COG0810@1|root,COG1432@1|root,COG0810@2|Bacteria,COG1432@2|Bacteria,1Q0F0@1224|Proteobacteria,2UC1N@28211|Alphaproteobacteria,3N8A0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
TLS2_k127_1017924_2	1267005.KB911255_gene2404	8.372e-143	466.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2TUAD@28211|Alphaproteobacteria,3N89M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PQQ-like domain	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
TLS2_k127_1017924_11	1267005.KB911255_gene2405	4.167e-48	183.0	COG4649@1|root,COG4649@2|Bacteria,1P2GI@1224|Proteobacteria,2UCFZ@28211|Alphaproteobacteria,3N73K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
TLS2_k127_1017924_9	1267005.KB911260_gene3470	1.877e-53	194.0	COG5458@1|root,COG5458@2|Bacteria,1N054@1224|Proteobacteria,2UBY1@28211|Alphaproteobacteria,3N78A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1489)	MA20_36070	-	-	-	-	-	-	-	-	-	-	-	DUF1489
TLS2_k127_1017924_0	426117.M446_2316	1.016e-209	675.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,1JT7G@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	Carbamoyl-phosphate synthase L chain	MA20_30205	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
TLS2_k127_1017924_3	670307.HYPDE_30393	1.457e-126	418.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2TR3B@28211|Alphaproteobacteria,3N6N0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
TLS2_k127_1060089_12	1140.Synpcc7942_1634	1.244e-07	54.0	COG0563@1|root,COG0563@2|Bacteria,1G4C4@1117|Cyanobacteria,1H0I0@1129|Synechococcus	1117|Cyanobacteria	F	COG0563 Adenylate kinase and related	-	-	-	-	-	-	-	-	-	-	-	-	IPT
TLS2_k127_1060089_9	1408419.JHYG01000008_gene2329	2.371e-66	234.0	COG3531@1|root,COG3531@2|Bacteria,1RIN9@1224|Proteobacteria,2UBM6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	DSBA-like thioredoxin domain	-	-	-	ko:K07396	-	-	-	-	ko00000	-	-	-	DSBA,Thioredoxin_5
TLS2_k127_1060089_5	1205680.CAKO01000002_gene2999	7.135e-92	306.0	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2TTY5@28211|Alphaproteobacteria,2JTFW@204441|Rhodospirillales	204441|Rhodospirillales	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_1060089_8	1267005.KB911260_gene3458	2.18e-70	253.0	COG0726@1|root,COG0726@2|Bacteria,1PJQG@1224|Proteobacteria,2TUBN@28211|Alphaproteobacteria,3N8V3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_1060089_10	1267005.KB911258_gene401	1.88e-40	157.0	COG2854@1|root,COG2854@2|Bacteria	2|Bacteria	Q	intermembrane phospholipid transfer	ttg2D	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
TLS2_k127_1060089_2	1123504.JQKD01000004_gene5026	4.839e-151	492.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2VI2F@28216|Betaproteobacteria,4AA58@80864|Comamonadaceae	28216|Betaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
TLS2_k127_1060089_3	1231190.NA8A_05258	2.328e-121	409.0	COG1638@1|root,COG1638@2|Bacteria,1MVYB@1224|Proteobacteria,2TT88@28211|Alphaproteobacteria,43M0B@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_1060089_7	1205680.CAKO01000002_gene2752	1.012e-70	244.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2TRRS@28211|Alphaproteobacteria,2JPTP@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase_C
TLS2_k127_1060089_0	1205680.CAKO01000002_gene2753	4.456e-230	720.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TVD2@28211|Alphaproteobacteria,2JV3W@204441|Rhodospirillales	204441|Rhodospirillales	E	Aconitase family (aconitate hydratase)	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase
TLS2_k127_1060089_6	1380394.JADL01000013_gene688	1.18e-91	309.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TTNG@28211|Alphaproteobacteria,2JRZ6@204441|Rhodospirillales	204441|Rhodospirillales	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_1060089_1	1205680.CAKO01000026_gene4594	3.981e-222	698.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1053 Succinate dehydrogenase fumarate reductase flavoprotein subunit	-	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
TLS2_k127_1060089_4	1380394.JADL01000007_gene4512	2.543e-103	344.0	COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,2TRNJ@28211|Alphaproteobacteria,2JQV0@204441|Rhodospirillales	204441|Rhodospirillales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
TLS2_k127_1126206_2	670307.HYPDE_31688	3.336e-86	289.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,2TR82@28211|Alphaproteobacteria,3N8VC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	GTP cyclohydrolase II	ribA	-	3.5.4.25,4.1.99.12	ko:K01497,ko:K14652	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
TLS2_k127_1126206_3	1417296.U879_11875	9.501e-16	83.0	COG2246@1|root,COG2246@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
TLS2_k127_1126206_1	622637.KE124774_gene831	2.252e-108	366.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2TRRT@28211|Alphaproteobacteria,36Y9Z@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Glycosyltransferase like family 2	MA20_05865	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
TLS2_k127_1126206_0	670307.HYPDE_35803	2.351e-110	364.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2TRSK@28211|Alphaproteobacteria,3N68N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein	MA20_17930	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TLS2_k127_114118_3	1122929.KB908215_gene1027	8.395e-165	528.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2TT0D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Threonine synthase	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0006082,GO:0006520,GO:0006566,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016311,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
TLS2_k127_114118_4	1267005.KB911255_gene2938	1.617e-144	472.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TR39@28211|Alphaproteobacteria,3N6HA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the peptidase M16 family	mpp	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_114118_11	1267005.KB911255_gene2939	2.276e-68	237.0	COG1670@1|root,COG1670@2|Bacteria,1MVG4@1224|Proteobacteria,2TUIK@28211|Alphaproteobacteria,3N6Y2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	rimJ	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS2_k127_114118_0	1267005.KB911255_gene2940	0.0	1162.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3N644@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC	MA20_18100	-	3.1.4.52	ko:K13245	ko04112,map04112	-	R08991	RC00296	ko00000,ko00001,ko01000	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,PAS_3
TLS2_k127_114118_1	670307.HYPDE_33418	1.957e-291	908.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2UQAG@28211|Alphaproteobacteria,3N62B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	ABC transporter	atm1	GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006996,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009507,GO:0009526,GO:0009536,GO:0009555,GO:0009657,GO:0009658,GO:0009889,GO:0009941,GO:0009987,GO:0010035,GO:0010038,GO:0010288,GO:0010380,GO:0016020,GO:0016043,GO:0018130,GO:0019222,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0019866,GO:0022622,GO:0030003,GO:0031090,GO:0031323,GO:0031326,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0042221,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046686,GO:0046916,GO:0048229,GO:0048364,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050790,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051186,GO:0051188,GO:0051189,GO:0051193,GO:0051276,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071840,GO:0090056,GO:0090407,GO:0098771,GO:0099402,GO:1901360,GO:1901362,GO:1901401,GO:1901463,GO:1901564,GO:1901566,GO:1901576	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_114118_8	1336243.JAEA01000012_gene2953	4.447e-96	324.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2TRPN@28211|Alphaproteobacteria,1JURR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
TLS2_k127_114118_2	78245.Xaut_2463	2.374e-265	827.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,3F104@335928|Xanthobacteraceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	MA20_29420	-	6.2.1.44,6.2.1.48	ko:K00666,ko:K02182,ko:K20034	ko00920,map00920	-	R10820	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_114118_6	1267005.KB911259_gene3896	5.52e-108	380.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,3N69H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
TLS2_k127_114118_12	1267005.KB911256_gene2077	7.51e-68	256.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,2TW0Q@28211|Alphaproteobacteria,3N9IK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	DM	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,Wzz
TLS2_k127_114118_5	1267005.KB911255_gene2667	9.705e-118	381.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2TQKR@28211|Alphaproteobacteria,3N69R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TLS2_k127_114118_10	582899.Hden_0234	3.521e-72	247.0	COG2001@1|root,COG2001@2|Bacteria,1MZB1@1224|Proteobacteria,2VG70@28211|Alphaproteobacteria,3N9I2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	MraZ protein, putative antitoxin-like	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
TLS2_k127_114118_7	1267005.KB911256_gene1663	3.313e-105	352.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2TRQA@28211|Alphaproteobacteria,3N6NV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
TLS2_k127_114118_13	1267005.KB911256_gene1662	8.112e-15	78.0	COG5462@1|root,COG5462@2|Bacteria	2|Bacteria	-	-	MA20_01770	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_114118_9	1267005.KB911256_gene1661	2.469e-93	325.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2TSHQ@28211|Alphaproteobacteria,3N62X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	penicillin-binding protein	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
TLS2_k127_1169296_0	883080.HMPREF9697_01362	0.0	1047.0	COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,2TTAQ@28211|Alphaproteobacteria,3JXCY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	xsc	-	2.3.3.15	ko:K03852	ko00430,map00430	-	R05651	RC02903,RC02909	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_1169296_4	1479238.JQMZ01000001_gene144	1.656e-37	149.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2TVD3@28211|Alphaproteobacteria,43XT2@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
TLS2_k127_1169296_3	555793.WSK_2995	1.607e-61	216.0	COG2318@1|root,COG2318@2|Bacteria,1RD3M@1224|Proteobacteria,2U8HG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	dinB	-	-	-	-	-	-	-	-	-	-	-	DinB
TLS2_k127_1169296_1	1380394.JADL01000003_gene4767	2.249e-253	796.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,2JUXN@204441|Rhodospirillales	204441|Rhodospirillales	EG	Belongs to the IlvD Edd family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS2_k127_1171152_2	582899.Hden_1133	1.932e-165	533.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,3N6BK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_1171152_6	1267005.KB911258_gene393	6.263e-112	366.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,3N698@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	ragA	GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_1171152_5	1267005.KB911258_gene394	3.591e-113	382.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2TUSJ@28211|Alphaproteobacteria,3N61U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_1171152_0	1267005.KB911258_gene395	0.0	1188.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,3N6D8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
TLS2_k127_1171152_11	1030157.AFMP01000016_gene2423	2.544e-09	68.0	COG5126@1|root,COG5126@2|Bacteria,1NH5D@1224|Proteobacteria,2UJHN@28211|Alphaproteobacteria,2K61Q@204457|Sphingomonadales	204457|Sphingomonadales	DTZ	EF-hand, calcium binding motif	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
TLS2_k127_1171152_9	717785.HYPMC_2360	1.767e-65	231.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2U5A1@28211|Alphaproteobacteria,3N7C5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	sigE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_1171152_12	1267005.KB911258_gene397	1.897e-06	57.0	2EG2K@1|root,339UJ@2|Bacteria,1NG8N@1224|Proteobacteria,2UJI4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1171152_7	1458357.BG58_40445	6.27e-102	338.0	COG1011@1|root,COG1011@2|Bacteria,1NYX7@1224|Proteobacteria,2VTWY@28216|Betaproteobacteria,1K4HK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_1171152_13	311402.Avi_3680	6.198e-05	49.0	COG5570@1|root,COG5570@2|Bacteria,1NGRE@1224|Proteobacteria,2UJAX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Small protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
TLS2_k127_1171152_8	1267005.KB911255_gene2475	1.187e-94	313.0	COG0349@1|root,COG0349@2|Bacteria,1MWFD@1224|Proteobacteria,2TQXS@28211|Alphaproteobacteria,3N6PC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	3'-5' exonuclease	rnd1	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1
TLS2_k127_1171152_4	1267005.KB911255_gene2474	8.677e-118	404.0	COG1934@1|root,COG5375@1|root,COG1934@2|Bacteria,COG5375@2|Bacteria,1Q8G1@1224|Proteobacteria,2VEP1@28211|Alphaproteobacteria,3N9AZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Lipopolysaccharide-assembly, LptC-related	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC,OstA
TLS2_k127_1171152_3	1267005.KB911255_gene2473	4.364e-129	422.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2TR7F@28211|Alphaproteobacteria,3N61R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ABC transporter	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_1171152_1	717785.HYPMC_0379	7.508e-175	562.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2TS41@28211|Alphaproteobacteria,3N637@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
TLS2_k127_1171152_10	1828.JOKB01000010_gene5327	5.496e-22	103.0	COG0582@1|root,COG0582@2|Bacteria,2I2PA@201174|Actinobacteria,4FXTI@85025|Nocardiaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_1182305_10	420324.KI911943_gene5321	6.023e-53	188.0	COG3090@1|root,COG3090@2|Bacteria,1QXYB@1224|Proteobacteria,2TTWD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_1182305_0	1089551.KE386572_gene3619	5.484e-209	657.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,4BRHR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	MA20_17100	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_1182305_15	1101191.KI912577_gene696	1.122e-19	93.0	COG3798@1|root,COG3798@2|Bacteria,1N9MY@1224|Proteobacteria,2UK7Q@28211|Alphaproteobacteria,1JVQ7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2171)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2171
TLS2_k127_1182305_7	1297570.MESS4_110115	1.163e-60	214.0	COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,2TT5N@28211|Alphaproteobacteria,43K44@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
TLS2_k127_1182305_11	1090320.KB900605_gene2172	5.427e-51	186.0	COG0346@1|root,COG0346@2|Bacteria,1RH8G@1224|Proteobacteria,2U9BR@28211|Alphaproteobacteria,2K5AH@204457|Sphingomonadales	204457|Sphingomonadales	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_1182305_3	1121861.KB899944_gene3879	5.663e-145	464.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2TTP8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
TLS2_k127_1182305_8	1415166.NONO_c27530	5.312e-59	214.0	COG1028@1|root,COG1028@2|Bacteria,2HFQ5@201174|Actinobacteria,4G78D@85025|Nocardiaceae	201174|Actinobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_1182305_9	1205680.CAKO01000030_gene4827	3.825e-55	195.0	COG3631@1|root,COG3631@2|Bacteria,1RE9H@1224|Proteobacteria,2UACM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	ko:K07255	ko00430,map00430	-	R01685	RC00062	ko00000,ko00001,ko01000	-	-	-	SnoaL_2
TLS2_k127_1182305_2	1502851.FG93_01382	2.493e-155	503.0	COG1680@1|root,COG1680@2|Bacteria,1MXHB@1224|Proteobacteria,2U4GK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_1182305_5	1123487.KB892835_gene3683	1.122e-112	398.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,2WHQF@28216|Betaproteobacteria	28216|Betaproteobacteria	T	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
TLS2_k127_1182305_6	1040989.AWZU01000037_gene7342	1.11e-89	306.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2TTDW@28211|Alphaproteobacteria,3JT60@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	-	-	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
TLS2_k127_1182305_14	1380394.JADL01000003_gene5124	9.436e-39	159.0	COG5501@1|root,COG5501@2|Bacteria,1N03V@1224|Proteobacteria,2TWQY@28211|Alphaproteobacteria,2JUCR@204441|Rhodospirillales	204441|Rhodospirillales	S	Sulphur oxidation protein SoxZ	-	-	-	-	-	-	-	-	-	-	-	-	SoxZ
TLS2_k127_1182305_13	1038859.AXAU01000003_gene5989	5.161e-48	176.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2U72E@28211|Alphaproteobacteria,3JUV9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sulfur oxidation protein SoxY	MA20_17510	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
TLS2_k127_1182305_12	1429916.X566_23365	2.4e-50	185.0	COG2010@1|root,COG2010@2|Bacteria,1RIV2@1224|Proteobacteria,2U9C5@28211|Alphaproteobacteria,3JZ5J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	ko:K17223	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
TLS2_k127_1182305_1	1211115.ALIQ01000228_gene1117	4.479e-171	547.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2TW6Z@28211|Alphaproteobacteria,3NBMU@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	fccB	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DUF442,Pyr_redox_2
TLS2_k127_1182305_16	1297570.MESS4_610042	9.478e-18	86.0	COG2863@1|root,COG2863@2|Bacteria,1PFWU@1224|Proteobacteria,2UHIY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS2_k127_1182305_4	1304878.AUGD01000007_gene5581	5.264e-136	437.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,3JSW3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	MA20_17495	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
TLS2_k127_1183903_8	331869.BAL199_06881	1.638e-27	115.0	COG2227@1|root,COG2227@2|Bacteria,1RE7I@1224|Proteobacteria,2TY3M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	PFAM Methyltransferase type	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1183903_4	670307.HYPDE_36108	2.011e-95	320.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2TTY7@28211|Alphaproteobacteria,3N6UI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0003674,GO:0003824,GO:0004735,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
TLS2_k127_1183903_7	648757.Rvan_3051	3.983e-43	168.0	COG1309@1|root,COG1309@2|Bacteria,1QE3S@1224|Proteobacteria,2U3XG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_1183903_3	335659.S23_25490	6.359e-107	353.0	COG0251@1|root,COG0251@2|Bacteria,1N1B6@1224|Proteobacteria,2TZWE@28211|Alphaproteobacteria,3JRZG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1183903_5	438753.AZC_1955	1.335e-68	242.0	COG3971@1|root,COG3971@2|Bacteria,1RFCI@1224|Proteobacteria,2UAZ0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	2-oxopent-4-enoate hydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
TLS2_k127_1183903_1	1333998.M2A_1040	7.989e-113	373.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2TQM0@28211|Alphaproteobacteria,4BPJR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
TLS2_k127_1183903_0	743836.AYNA01000080_gene2800	2.244e-144	466.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2TRXE@28211|Alphaproteobacteria,36XHZ@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Ribosomal protein S2	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
TLS2_k127_1183903_6	1380394.JADL01000009_gene3168	7.583e-65	229.0	COG1802@1|root,COG1802@2|Bacteria,1RKMP@1224|Proteobacteria,2UAUH@28211|Alphaproteobacteria,2JTN9@204441|Rhodospirillales	204441|Rhodospirillales	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_1183903_2	411684.HPDFL43_18637	5.811e-108	353.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TQJR@28211|Alphaproteobacteria,43H7Z@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A	prpE	-	6.2.1.1,6.2.1.17	ko:K01895,ko:K01908	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_1185764_12	68570.DC74_2087	2.539e-09	69.0	COG0526@1|root,COG0526@2|Bacteria,2I2YN@201174|Actinobacteria	201174|Actinobacteria	CO	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans
TLS2_k127_1185764_4	1205680.CAKO01000040_gene1082	4.952e-77	262.0	COG3576@1|root,COG3576@2|Bacteria,1NBWC@1224|Proteobacteria,2U6NS@28211|Alphaproteobacteria,2JY92@204441|Rhodospirillales	204441|Rhodospirillales	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_1185764_1	1429916.X566_04370	2.397e-154	512.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTDF@28211|Alphaproteobacteria,3JTWQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	MA20_16405	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_C_2,GST_N
TLS2_k127_1185764_2	930169.B5T_01627	1.455e-129	420.0	COG3386@1|root,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,1RQXB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	gluconolactonase	gnl	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
TLS2_k127_1185764_5	1547437.LL06_20655	1.271e-61	222.0	COG3685@1|root,COG3685@2|Bacteria,1REKN@1224|Proteobacteria,2U73U@28211|Alphaproteobacteria,43JV8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF892
TLS2_k127_1185764_3	1382359.JIAL01000001_gene1412	4.312e-77	265.0	COG0457@1|root,COG4122@1|root,COG0457@2|Bacteria,COG4122@2|Bacteria,3Y6S8@57723|Acidobacteria,2JKGG@204432|Acidobacteriia	204432|Acidobacteriia	S	Macrocin-O-methyltransferase (TylF)	-	-	-	-	-	-	-	-	-	-	-	-	TylF
TLS2_k127_1185764_15	1033810.HLPCO_001427	0.00013	51.0	COG0330@1|root,COG0330@2|Bacteria,2NNUC@2323|unclassified Bacteria	2|Bacteria	O	prohibitin homologues	qmcA	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_1185764_13	396014.BF93_11890	1.576e-08	67.0	COG3664@1|root,COG3664@2|Bacteria,2GNYC@201174|Actinobacteria	201174|Actinobacteria	G	PFAM glycoside hydrolase family 39	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	F5_F8_type_C,Glyco_hydro_39
TLS2_k127_1185764_11	1223523.H340_05329	3.295e-17	93.0	2EWW5@1|root,33Q7K@2|Bacteria,2IC6T@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1185764_10	1449347.JQLN01000005_gene4993	5.078e-19	99.0	2EWW5@1|root,33Q7K@2|Bacteria,2IC6T@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1185764_9	219305.MCAG_03660	8.041e-21	106.0	2EWW5@1|root,33Q7K@2|Bacteria,2IC6T@201174|Actinobacteria,4DHM2@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1185764_6	709032.Sulku_2396	2.198e-58	215.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,42MWH@68525|delta/epsilon subdivisions,2YMPE@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	epimerase dehydratase family	-	-	5.1.3.2,5.1.3.6	ko:K01784,ko:K08679	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01385,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS2_k127_1185764_0	1187851.A33M_2147	1.666e-166	530.0	COG0451@1|root,COG0451@2|Bacteria,1QUEV@1224|Proteobacteria,2TW46@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	epimerase dehydratase	rfbE	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS2_k127_1185764_7	1187851.A33M_1215	7.02e-57	217.0	COG2304@1|root,COG4249@1|root,COG2304@2|Bacteria,COG4249@2|Bacteria,1MXFD@1224|Proteobacteria,2TR94@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
TLS2_k127_1185764_8	1244869.H261_02756	8.994e-33	129.0	COG3542@1|root,COG3542@2|Bacteria,1RHBE@1224|Proteobacteria,2U962@28211|Alphaproteobacteria,2JSSJ@204441|Rhodospirillales	204441|Rhodospirillales	S	Cupin superfamily (DUF985)	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
TLS2_k127_1224066_16	1380355.JNIJ01000048_gene20	8.843e-07	53.0	COG3847@1|root,COG3847@2|Bacteria,1NMHD@1224|Proteobacteria,2UMQE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	PFAM Flp Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
TLS2_k127_1224066_13	1333998.M2A_1841	2.352e-15	85.0	COG4961@1|root,COG4961@2|Bacteria,1N744@1224|Proteobacteria,2UGR2@28211|Alphaproteobacteria,4BSPB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	U	Flp pilus assembly protein TadG	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS2_k127_1224066_12	1122613.ATUP01000001_gene2004	7.915e-24	111.0	COG4961@1|root,COG4961@2|Bacteria,1N3XK@1224|Proteobacteria,2UBRJ@28211|Alphaproteobacteria,43XYP@69657|Hyphomonadaceae	28211|Alphaproteobacteria	U	TadE-like protein	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	TadE
TLS2_k127_1224066_9	998674.ATTE01000001_gene883	8.031e-92	311.0	COG1028@1|root,COG1028@2|Bacteria,1RBGC@1224|Proteobacteria,1S4IK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_1224066_14	1071085.KK033114_gene736	3.683e-15	88.0	arCOG08934@1|root,arCOG08934@2157|Archaea,2XXBA@28890|Euryarchaeota	28890|Euryarchaeota	Q	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_1224066_8	1205680.CAKO01000002_gene2536	1.073e-120	394.0	COG0596@1|root,COG0596@2|Bacteria,1NDHC@1224|Proteobacteria,2UPRH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_1224066_7	331869.BAL199_11871	1.615e-122	400.0	COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_1224066_11	1211115.ALIQ01000228_gene1109	7.738e-54	203.0	COG1755@1|root,COG1755@2|Bacteria,1RERZ@1224|Proteobacteria,2U77M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Isoprenylcysteine carboxyl methyltransferase	-	-	-	ko:K16168	-	-	-	-	ko00000,ko01008	-	-	-	ICMT
TLS2_k127_1224066_6	1230476.C207_02214	7.734e-123	404.0	COG3424@1|root,COG3424@2|Bacteria,1MUDX@1224|Proteobacteria,2TRTX@28211|Alphaproteobacteria,3JVCF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Chalcone and stilbene synthases, C-terminal domain	-	-	-	ko:K16167	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
TLS2_k127_1224066_15	1267005.KB911258_gene122	2.746e-08	56.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria,3N61B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	5-aminolevulinic acid synthase	hemA	-	2.3.1.37	ko:K00643	ko00260,ko00860,ko01100,ko01110,map00260,map00860,map01100,map01110	-	R00830	RC00004,RC02815	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_1224066_10	1267005.KB911258_gene121	1.595e-70	248.0	COG4235@1|root,COG4235@2|Bacteria	2|Bacteria	O	cytochrome complex assembly	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_11,TPR_14,TPR_16,TPR_2
TLS2_k127_1224066_1	1267005.KB911258_gene119	1.247e-236	749.0	2EF1J@1|root,338UN@2|Bacteria,1P071@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1224066_0	1267005.KB911258_gene118	2.922e-308	959.0	COG4885@1|root,COG4885@2|Bacteria,1R65B@1224|Proteobacteria,2UJP4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
TLS2_k127_1224066_3	1267005.KB911258_gene117	2.354e-166	532.0	COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1R4UA@1224|Proteobacteria,2TTQ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Oxidoreductase FAD NAD(P)-binding domain protein	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
TLS2_k127_1224066_5	1267005.KB911258_gene115	7.165e-130	420.0	28UM4@1|root,2ZGRN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1224066_2	1267005.KB911258_gene114	2.817e-229	732.0	2FBW8@1|root,3440T@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_123914_12	1461694.ATO9_04870	1.401e-17	89.0	COG2863@1|root,COG3474@1|root,COG2863@2|Bacteria,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,2UCUT@28211|Alphaproteobacteria,2PDK8@252301|Oceanicola	28211|Alphaproteobacteria	C	Cytochrome c	soxE	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
TLS2_k127_123914_11	582899.Hden_0682	4.563e-32	130.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2UFSY@28211|Alphaproteobacteria,3N791@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	PFAM regulatory protein ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
TLS2_k127_123914_10	1038866.KB902768_gene5020	2.238e-45	172.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2U96P@28211|Alphaproteobacteria,3JYWC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	subunit of a heme lyase	cycL	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
TLS2_k127_123914_0	1267005.KB911258_gene389	0.0	1008.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2TRNG@28211|Alphaproteobacteria,3N6JZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Cytochrome c-type biogenesis protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
TLS2_k127_123914_9	419610.Mext_1407	5.828e-46	183.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2U99J@28211|Alphaproteobacteria,1JTMD@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	GO:0003674,GO:0003824,GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
TLS2_k127_123914_8	670307.HYPDE_32013	3.561e-79	280.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2TSI7@28211|Alphaproteobacteria,3N752@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Cytochrome c-type biogenesis protein	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_19
TLS2_k127_123914_2	670307.HYPDE_32023	5.391e-149	484.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,2TS9N@28211|Alphaproteobacteria,3N6N6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Signal transduction histidine kinase	feuQ	-	-	-	-	-	-	-	-	-	-	-	2CSK_N,HATPase_c
TLS2_k127_123914_3	1267005.KB911258_gene384	1.27e-117	381.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2TSV8@28211|Alphaproteobacteria,3N6AA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Two component transcriptional regulator	feuP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_123914_6	1297863.APJF01000001_gene1945	2.109e-101	338.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,3JUR1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_123914_4	443598.AUFA01000014_gene6964	4.519e-112	368.0	COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2TRPS@28211|Alphaproteobacteria,3JREH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	MA20_40175	-	4.2.1.18,4.2.1.57	ko:K13766,ko:K13779	ko00280,ko00281,ko01100,map00280,map00281,map01100	M00036	R02085,R03493	RC00941,RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_123914_1	1380355.JNIJ01000070_gene5806	4.843e-157	506.0	COG2267@1|root,COG2267@2|Bacteria,1QU7K@1224|Proteobacteria,2U0H3@28211|Alphaproteobacteria,3JR1E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	2.7.10.2,3.3.2.9	ko:K01253,ko:K08253	ko00980,ko04976,ko05204,map00980,map04976,map05204	-	R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443	RC01447,RC01728,RC01764,RC02528	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
TLS2_k127_123914_7	648757.Rvan_0764	7.649e-96	324.0	COG0500@1|root,COG2226@2|Bacteria,1NDFZ@1224|Proteobacteria,2TVI5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_123914_5	1267005.KB911264_gene3203	1.294e-106	351.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,3N6PA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	1.1.1.53	ko:K00038	ko00140,ko01100,map00140,map01100	-	R04831,R04834,R04844,R04847	RC00139,RC01219,RC01220	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
TLS2_k127_1241870_5	1198232.CYCME_1184	1.122e-59	208.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,45ZWN@72273|Thiotrichales	72273|Thiotrichales	IQ	reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_1241870_4	1380394.JADL01000009_gene3136	1.543e-103	353.0	COG0111@1|root,COG0111@2|Bacteria,1NU4B@1224|Proteobacteria,2TZ0Y@28211|Alphaproteobacteria,2JVW6@204441|Rhodospirillales	204441|Rhodospirillales	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_1241870_6	670307.HYPDE_22708	2.812e-50	191.0	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2TR0C@28211|Alphaproteobacteria,3N71V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CO	Thioredoxin-like	tlpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_1241870_1	717785.HYPMC_0045	1.027e-237	743.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2TR4H@28211|Alphaproteobacteria,3N69U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
TLS2_k127_1241870_3	1510531.JQJJ01000010_gene2595	2.32e-182	581.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2TQPB@28211|Alphaproteobacteria,3JU3D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS2_k127_1241870_0	1267005.KB911257_gene1073	4.118e-248	793.0	COG1511@1|root,COG1511@2|Bacteria,1QY7Q@1224|Proteobacteria,2TXIQ@28211|Alphaproteobacteria,3N82W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4175
TLS2_k127_1241870_2	1267005.KB911257_gene845	8.89e-201	644.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TSTS@28211|Alphaproteobacteria,3N73F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	sfuB	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
TLS2_k127_1249863_3	1071679.BG57_00810	1.739e-103	340.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2VK17@28216|Betaproteobacteria,1K1YW@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_1249863_4	323097.Nham_2562	2.822e-81	282.0	COG4976@1|root,COG4976@2|Bacteria,1R9Q0@1224|Proteobacteria,2TY2X@28211|Alphaproteobacteria,3K6WA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1249863_6	395965.Msil_2227	1.372e-46	179.0	COG2755@1|root,COG2755@2|Bacteria,1MWPZ@1224|Proteobacteria,2TSYR@28211|Alphaproteobacteria,3N9WZ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS2_k127_1249863_2	876269.ARWA01000001_gene3604	1.309e-116	387.0	COG4645@1|root,COG4645@2|Bacteria,1PI9Q@1224|Proteobacteria,2U1C7@28211|Alphaproteobacteria,3NA8K@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	OpgC protein	-	-	-	-	-	-	-	-	-	-	-	-	OpgC_C
TLS2_k127_1249863_1	1267005.KB911258_gene148	2.17e-322	1006.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TRI9@28211|Alphaproteobacteria,3N6Q7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	MMPL family	MA20_16090	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_1249863_5	1267005.KB911258_gene89	1.141e-80	272.0	2C1A0@1|root,2ZX64@2|Bacteria	2|Bacteria	S	Type VI secretion system (T6SS), amidase effector protein 4	-	-	-	-	-	-	-	-	-	-	-	-	Tae4
TLS2_k127_1249863_0	1267005.KB911255_gene2999	0.0	1007.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,3N63K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TLS2_k127_1320297_1	395965.Msil_1512	0.0	1593.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2TSXZ@28211|Alphaproteobacteria,3NAH0@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	PFAM major facilitator superfamily MFS_1	narK	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
TLS2_k127_1320297_0	1205680.CAKO01000002_gene2729	0.0	2262.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2TQJW@28211|Alphaproteobacteria,2JPZU@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narZ	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
TLS2_k127_1320297_2	395965.Msil_1509	9.47e-28	112.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria	1224|Proteobacteria	C	nitrate reductase beta subunit	narH	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
TLS2_k127_1391806_11	296591.Bpro_0079	1.44e-81	275.0	COG0625@1|root,COG0625@2|Bacteria,1NE6Z@1224|Proteobacteria,2VNKQ@28216|Betaproteobacteria,4AFF2@80864|Comamonadaceae	28216|Betaproteobacteria	H	PFAM Glutathione S-transferase domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
TLS2_k127_1391806_14	1500306.JQLA01000003_gene4733	9.917e-20	90.0	COG0625@1|root,COG0625@2|Bacteria,1NE6Z@1224|Proteobacteria,2TVN6@28211|Alphaproteobacteria,4B7TJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_C_3,GST_N
TLS2_k127_1391806_2	1500301.JQMF01000022_gene5708	3.686e-194	615.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,4B9PJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	dehydrogenase	lpdA2	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_1391806_6	59538.XP_005973307.1	6.083e-144	479.0	COG0508@1|root,KOG0558@2759|Eukaryota,38CZZ@33154|Opisthokonta,3BANT@33208|Metazoa,3CT3S@33213|Bilateria,47ZEV@7711|Chordata,4918X@7742|Vertebrata,3J8JF@40674|Mammalia,4IY5E@91561|Cetartiodactyla	2759|Eukaryota	C	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005947,GO:0009295,GO:0019899,GO:0030062,GO:0031625,GO:0031974,GO:0032991,GO:0042645,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044389,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0070013,GO:0098798,GO:1902494,GO:1990204	2.3.1.168,3.6.4.13	ko:K09699,ko:K11273	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R02662,R03174,R04097,R10998	RC00004,RC02727,RC02870	br01601,ko00000,ko00001,ko00002,ko01000,ko03036	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_1391806_3	935261.JAGL01000010_gene1917	1.885e-187	588.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,43HA2@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase	bkdA2	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_1391806_1	331869.BAL199_28350	2.277e-220	689.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TSEI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit	bkdA1	-	1.2.4.4	ko:K00166	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,OxoDH_E1alpha_N
TLS2_k127_1391806_12	1207063.P24_10076	3.669e-64	222.0	COG1917@1|root,COG1917@2|Bacteria,1RHQF@1224|Proteobacteria,2UNPY@28211|Alphaproteobacteria,2JWTT@204441|Rhodospirillales	204441|Rhodospirillales	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1391806_0	1380355.JNIJ01000050_gene136	0.0	1041.0	COG0348@1|root,COG3889@1|root,COG0348@2|Bacteria,COG3889@2|Bacteria,1R9JQ@1224|Proteobacteria,2U3WR@28211|Alphaproteobacteria,3K36U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1391806_13	1038859.AXAU01000028_gene29	8.727e-35	136.0	2BGXJ@1|root,32AXJ@2|Bacteria,1NHJS@1224|Proteobacteria,2UN1Q@28211|Alphaproteobacteria,3K4PM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1391806_7	1380355.JNIJ01000050_gene134	1.242e-137	459.0	2BSZ4@1|root,32N30@2|Bacteria,1NTM8@1224|Proteobacteria,2UNVX@28211|Alphaproteobacteria,3K2SH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1391806_10	1380355.JNIJ01000050_gene133	2.559e-119	387.0	COG0410@1|root,COG0410@2|Bacteria,1R6QK@1224|Proteobacteria,2U82Z@28211|Alphaproteobacteria,3JZBP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_1391806_9	1380355.JNIJ01000050_gene132	6.699e-121	393.0	COG0411@1|root,COG0411@2|Bacteria,1R5MA@1224|Proteobacteria,2TV7Q@28211|Alphaproteobacteria,3JZDF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_1391806_5	1380355.JNIJ01000050_gene131	2.092e-155	496.0	COG4177@1|root,COG4177@2|Bacteria,1N5I8@1224|Proteobacteria,2U0PT@28211|Alphaproteobacteria,3JSC7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_1391806_8	1380355.JNIJ01000050_gene130	4.624e-137	441.0	COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2TTC6@28211|Alphaproteobacteria,3JSJ8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_1391806_4	1380355.JNIJ01000050_gene129	6.221e-166	544.0	COG3889@1|root,COG3889@2|Bacteria,1R6EI@1224|Proteobacteria,2UQR6@28211|Alphaproteobacteria,3K2HR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1406526_0	1267005.KB911257_gene1101	1.309e-199	627.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2TQTQ@28211|Alphaproteobacteria,3N6EP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
TLS2_k127_1406526_2	1267005.KB911257_gene1089	1.219e-75	260.0	COG1670@1|root,COG1670@2|Bacteria,1QVE8@1224|Proteobacteria,2TWDB@28211|Alphaproteobacteria,3N8KV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_1406526_4	1267005.KB911257_gene876	9.183e-10	65.0	2EH7Y@1|root,33AZT@2|Bacteria,1NK5P@1224|Proteobacteria,2UK81@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1406526_3	380394.Lferr_0153	1.78e-46	181.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,1RSGJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	COG0451 Nucleoside-diphosphate-sugar epimerases	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
TLS2_k127_1406526_1	717785.HYPMC_2611	1.092e-144	466.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2TRMT@28211|Alphaproteobacteria,3N7BG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh
TLS2_k127_1406526_5	670307.HYPDE_33868	1.595e-05	48.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,3N68D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_1432899_2	1041142.ATTP01000007_gene6072	1.346e-54	196.0	COG1917@1|root,COG1917@2|Bacteria,1RAM0@1224|Proteobacteria,2U7VD@28211|Alphaproteobacteria,4BEXP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_1432899_1	1380355.JNIJ01000026_gene1316	2.129e-114	375.0	COG0702@1|root,COG0702@2|Bacteria,1MYVU@1224|Proteobacteria,2TTHA@28211|Alphaproteobacteria,3JUST@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
TLS2_k127_1432899_0	1500257.JQNM01000006_gene2103	1.556e-263	821.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9US@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Trans_reg_C
TLS2_k127_1432899_4	1121033.AUCF01000016_gene5539	2.518e-09	67.0	COG1177@1|root,COG1177@2|Bacteria,1R5TG@1224|Proteobacteria,2TUP9@28211|Alphaproteobacteria,2JW6U@204441|Rhodospirillales	204441|Rhodospirillales	E	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_1432899_3	1089551.KE386572_gene1390	2.314e-17	95.0	2DTDG@1|root,33JUW@2|Bacteria,1NQ9U@1224|Proteobacteria,2UM34@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1432899_5	1267533.KB906738_gene2279	1.475e-08	66.0	COG3652@1|root,COG3652@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4142)	-	-	-	ko:K08995	-	-	-	-	ko00000	-	-	-	DUF4142
TLS2_k127_1432899_6	626418.bglu_1g11680	0.0005353	51.0	COG3652@1|root,COG3652@2|Bacteria,1N6QU@1224|Proteobacteria,2VTZW@28216|Betaproteobacteria,1K85S@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4142)	-	-	-	ko:K08995	-	-	-	-	ko00000	-	-	-	DUF4142
TLS2_k127_1462565_2	1411123.JQNH01000001_gene3100	8.333e-137	443.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system fused permease components	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_1462565_3	1411123.JQNH01000001_gene3101	2.229e-135	439.0	COG2358@1|root,COG2358@2|Bacteria,1N3YB@1224|Proteobacteria,2TTNT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TRAP transporter solute receptor TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
TLS2_k127_1462565_1	420324.KI912060_gene5857	3.719e-190	599.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TSBB@28211|Alphaproteobacteria,1JRK9@119045|Methylobacteriaceae	28211|Alphaproteobacteria	CE	PFAM isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.83,1.1.1.93,4.1.1.73	ko:K07246	ko00630,ko00650,map00630,map00650	-	R00215,R01751,R02545,R06180	RC00084,RC00105,RC00594	ko00000,ko00001,ko01000	-	-	-	Iso_dh
TLS2_k127_1462565_4	670307.HYPDE_34243	7.04e-131	427.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2VET4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
TLS2_k127_1462565_0	670307.HYPDE_34248	2.542e-293	917.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
TLS2_k127_1484279_19	1267005.KB911256_gene1639	4.542e-53	193.0	COG5478@1|root,COG5478@2|Bacteria,1MZMZ@1224|Proteobacteria,2UBR2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	small integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Iron_permease
TLS2_k127_1484279_23	314231.FP2506_12649	3.698e-31	127.0	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,2UBSC@28211|Alphaproteobacteria,2PJZA@255475|Aurantimonadaceae	28211|Alphaproteobacteria	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
TLS2_k127_1484279_1	1380394.JADL01000003_gene4832	1.394e-271	849.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,2JSIF@204441|Rhodospirillales	204441|Rhodospirillales	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2,Pyr_redox_3
TLS2_k127_1484279_3	247633.GP2143_07474	6.912e-235	741.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
TLS2_k127_1484279_8	1205680.CAKO01000029_gene4999	3.412e-145	479.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2TR4R@28211|Alphaproteobacteria,2JQNM@204441|Rhodospirillales	204441|Rhodospirillales	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
TLS2_k127_1484279_27	1038859.AXAU01000001_gene3361	5.509e-15	85.0	COG5010@1|root,COG5010@2|Bacteria,1MVTK@1224|Proteobacteria,2TVD4@28211|Alphaproteobacteria,3JRRX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
TLS2_k127_1484279_4	1207063.P24_12527	1.797e-214	672.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2TQW9@28211|Alphaproteobacteria,2JPGS@204441|Rhodospirillales	204441|Rhodospirillales	E	COG2873 O-acetylhomoserine sulfhydrylase	-	-	-	-	-	-	-	-	-	-	-	-	Cys_Met_Meta_PP
TLS2_k127_1484279_2	648757.Rvan_2964	2.155e-257	799.0	COG0604@1|root,COG0604@2|Bacteria,1MXIK@1224|Proteobacteria,2TQPR@28211|Alphaproteobacteria,3N7S6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	reductase	ccrA	-	1.1.1.1,1.3.1.85	ko:K00001,ko:K14446	ko00010,ko00071,ko00350,ko00625,ko00626,ko00630,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00071,map00350,map00625,map00626,map00630,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220	M00373	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R09291	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC02481	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_1484279_20	748280.NH8B_4077	5.999e-50	188.0	COG0676@1|root,COG0676@2|Bacteria,1Q7VN@1224|Proteobacteria,2VKZK@28216|Betaproteobacteria,2KRUX@206351|Neisseriales	206351|Neisseriales	G	Belongs to the glucose-6-phosphate 1-epimerase family	-	-	5.1.3.15	ko:K01792	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130	-	R02739	RC00563	ko00000,ko00001,ko01000	-	-	-	Aldose_epim
TLS2_k127_1484279_5	402626.Rpic_4817	4.213e-155	497.0	COG2070@1|root,COG2070@2|Bacteria,1MU0U@1224|Proteobacteria,2VH48@28216|Betaproteobacteria,1JZTF@119060|Burkholderiaceae	28216|Betaproteobacteria	S	2-Nitropropane dioxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
TLS2_k127_1484279_12	246200.SPO0268	1.715e-90	305.0	COG0054@1|root,COG0054@2|Bacteria,1RHCZ@1224|Proteobacteria,2U5EC@28211|Alphaproteobacteria,4NBYE@97050|Ruegeria	28211|Alphaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH2	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
TLS2_k127_1484279_9	1267005.KB911256_gene1958	8.423e-111	369.0	COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2TUPZ@28211|Alphaproteobacteria,3N6PW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	N-formylglutamate amidohydrolase	MA20_06380	-	3.5.1.68	ko:K01458	ko00340,ko00630,map00340,map00630	-	R00525	RC00165,RC00323	ko00000,ko00001,ko01000	-	-	-	FGase
TLS2_k127_1484279_17	717785.HYPMC_0753	4.011e-57	205.0	COG0745@1|root,COG0745@2|Bacteria,1QUSA@1224|Proteobacteria,2TW5G@28211|Alphaproteobacteria,3N6Y8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Response regulator receiver	QU41_05915	-	-	ko:K13589	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
TLS2_k127_1484279_29	670307.HYPDE_41723	4.473e-07	61.0	COG1426@1|root,COG1426@2|Bacteria	2|Bacteria	S	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_25,HTH_3
TLS2_k127_1484279_6	1267005.KB911255_gene2507	6.609e-150	481.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2TQSV@28211|Alphaproteobacteria,3N6BP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS2_k127_1484279_14	1287276.X752_01580	2.93e-66	238.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2TZFK@28211|Alphaproteobacteria,43IJR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
TLS2_k127_1484279_21	1267005.KB911255_gene2509	2.622e-36	149.0	COG5373@1|root,COG5373@2|Bacteria,1N7JV@1224|Proteobacteria,2TR7A@28211|Alphaproteobacteria,3N76S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4167)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4167
TLS2_k127_1484279_7	1267005.KB911265_gene3617	9.147e-146	471.0	COG0560@1|root,COG0560@2|Bacteria,1R6HK@1224|Proteobacteria,2TV4J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
TLS2_k127_1484279_15	1267005.KB911264_gene3147	8.941e-65	233.0	COG4249@1|root,COG4249@2|Bacteria,1MXFD@1224|Proteobacteria,2TR94@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,Sel1
TLS2_k127_1484279_13	582899.Hden_0621	7.878e-90	302.0	COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,2TV1D@28211|Alphaproteobacteria,3N6ZT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Glycerophosphoryl diester phosphodiesterase family	ugpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS2_k127_1484279_26	398525.KB900701_gene2466	2.001e-17	85.0	COG3027@1|root,COG3027@2|Bacteria,1N8NY@1224|Proteobacteria,2UCRX@28211|Alphaproteobacteria,3JZUM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	MA20_17980	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
TLS2_k127_1484279_18	1267005.KB911256_gene1930	2.267e-56	209.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2U77S@28211|Alphaproteobacteria,3N6WI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_1484279_10	1267005.KB911256_gene1929	6.041e-108	355.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2TTTF@28211|Alphaproteobacteria,3N74D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
TLS2_k127_1484279_25	717785.HYPMC_1174	1.974e-26	117.0	COG3216@1|root,COG3216@2|Bacteria,1QA1I@1224|Proteobacteria,2TS9W@28211|Alphaproteobacteria,3N7B5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2062)	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
TLS2_k127_1484279_0	1267005.KB911256_gene1928	0.0	1097.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2TQNY@28211|Alphaproteobacteria,3N62U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TLS2_k127_1484279_16	1267005.KB911256_gene1927	3.773e-60	211.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,2U9BQ@28211|Alphaproteobacteria,3N733@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
TLS2_k127_1484279_24	648757.Rvan_2205	2.213e-29	124.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2U8D6@28211|Alphaproteobacteria,3N7CA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
TLS2_k127_1484279_11	670307.HYPDE_34178	9.467e-94	311.0	COG1432@1|root,COG1432@2|Bacteria,1MUAE@1224|Proteobacteria,2TU5M@28211|Alphaproteobacteria,3N6N3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	MA20_36560	-	-	-	-	-	-	-	-	-	-	-	NYN
TLS2_k127_1484279_30	985054.JQEZ01000003_gene1624	2.064e-06	51.0	COG0454@1|root,COG0456@2|Bacteria,1RCBE@1224|Proteobacteria,2U1JB@28211|Alphaproteobacteria,4NAF0@97050|Ruegeria	28211|Alphaproteobacteria	K	Acetyltransferase, gnat family	yobR	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_149558_2	391735.Veis_1581	8.08e-168	537.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VJGI@28216|Betaproteobacteria,4ABXU@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS2_k127_149558_10	670307.HYPDE_39453	9.863e-114	374.0	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,2TS7W@28211|Alphaproteobacteria,3N6DG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_149558_0	1205680.CAKO01000005_gene3511	2.114e-216	685.0	COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,2TSRQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	succinate dehydrogenase fumarate reductase, flavoprotein subunit	MA20_00690	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
TLS2_k127_149558_5	991905.SL003B_1137	2.341e-146	483.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2TQU7@28211|Alphaproteobacteria,4BPBG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TLS2_k127_149558_13	1267005.KB911259_gene3758	6.978e-96	319.0	COG0500@1|root,COG2226@2|Bacteria,1MVIS@1224|Proteobacteria,2TV8R@28211|Alphaproteobacteria,3N8F9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	pmtA	-	2.1.1.17,2.1.1.71	ko:K00570	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00091	R01320,R02056,R03424	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
TLS2_k127_149558_6	1267005.KB911256_gene2061	2.184e-144	463.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2TSN3@28211|Alphaproteobacteria,3N6GE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_149558_11	1122132.AQYH01000002_gene1428	4.515e-99	333.0	COG1028@1|root,COG1028@2|Bacteria,1MURZ@1224|Proteobacteria,2TQJ6@28211|Alphaproteobacteria,4B8QX@82115|Rhizobiaceae	28211|Alphaproteobacteria	IQ	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	MA20_27190	-	1.1.1.30	ko:K00019,ko:K18335	ko00051,ko00072,ko00650,ko01100,ko01120,map00051,map00072,map00650,map01100,map01120	M00088	R01361,R10690	RC00089,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
TLS2_k127_149558_16	717785.HYPMC_4752	3.518e-53	195.0	COG3807@1|root,COG3807@2|Bacteria,1RHM2@1224|Proteobacteria,2UA1R@28211|Alphaproteobacteria,3N70X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Bacterial SH3 domain homologues	-	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	SH3_4
TLS2_k127_149558_12	670307.HYPDE_23898	3.278e-98	328.0	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2TRMG@28211|Alphaproteobacteria,3N8BU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
TLS2_k127_149558_14	1197906.CAJQ02000038_gene4678	4.424e-74	257.0	COG0730@1|root,COG0730@2|Bacteria,1MVYH@1224|Proteobacteria,2TTY0@28211|Alphaproteobacteria,3JS7X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	MA20_27970	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_149558_7	1267005.KB911256_gene1993	6.184e-143	462.0	COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2TR9C@28211|Alphaproteobacteria,3N6CJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	aapM	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
TLS2_k127_149558_4	1120983.KB894570_gene1882	4.714e-150	484.0	COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,2TR7G@28211|Alphaproteobacteria,1JN5Z@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K09970	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
TLS2_k127_149558_3	1547437.LL06_06215	2.218e-154	495.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TSRF@28211|Alphaproteobacteria,43HJJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	ET	COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	aapJ	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
TLS2_k127_149558_8	1380394.JADL01000009_gene3427	3.352e-125	404.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,2JPJB@204441|Rhodospirillales	204441|Rhodospirillales	E	acid transport	-	-	-	ko:K09972	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
TLS2_k127_149558_15	1267005.KB911260_gene3422	1.54e-73	261.0	COG0790@1|root,COG0790@2|Bacteria,1MUGD@1224|Proteobacteria,2TRV0@28211|Alphaproteobacteria,3N78Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PFAM Sel1 domain protein repeat-containing protein	exoR	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
TLS2_k127_149558_9	1267005.KB911260_gene3423	7.728e-122	395.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2TR5J@28211|Alphaproteobacteria,3N679@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
TLS2_k127_149558_1	693986.MOC_3482	9.492e-192	613.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TRWB@28211|Alphaproteobacteria,1JQPF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS2_k127_149558_17	795666.MW7_1339	3.221e-31	133.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2VKB0@28216|Betaproteobacteria,1K405@119060|Burkholderiaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_1495912_1	717785.HYPMC_4054	6.328e-204	647.0	COG0489@1|root,COG2151@1|root,COG3536@1|root,COG0489@2|Bacteria,COG2151@2|Bacteria,COG3536@2|Bacteria,1MU7R@1224|Proteobacteria,2TRDM@28211|Alphaproteobacteria,3N6F8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
TLS2_k127_1495912_3	1424334.W822_18455	1.109e-124	412.0	COG0683@1|root,COG0683@2|Bacteria,1MVV2@1224|Proteobacteria,2VIK5@28216|Betaproteobacteria,3T31H@506|Alcaligenaceae	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_1495912_4	1267005.KB911259_gene3859	4.594e-113	377.0	COG1752@1|root,COG1752@2|Bacteria,1MVHW@1224|Proteobacteria,2TS4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS2_k127_1495912_6	1211115.ALIQ01000246_gene241	7.214e-55	214.0	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,2TV55@28211|Alphaproteobacteria,3NB9I@45404|Beijerinckiaceae	28211|Alphaproteobacteria	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
TLS2_k127_1495912_5	1123247.AUIJ01000019_gene39	4.167e-106	357.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2TR9A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
TLS2_k127_1495912_7	1089552.KI911559_gene2426	4.991e-46	177.0	COG0614@1|root,COG0614@2|Bacteria,1RAUP@1224|Proteobacteria,2TUB0@28211|Alphaproteobacteria,2JSZ7@204441|Rhodospirillales	204441|Rhodospirillales	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS2_k127_1495912_0	717785.HYPMC_2989	5.4e-323	999.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2TT32@28211|Alphaproteobacteria,3N6B3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
TLS2_k127_1495912_2	426355.Mrad2831_4892	1.6e-159	512.0	COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2TT84@28211|Alphaproteobacteria,1JS3J@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0061 (SELO) family	MA20_28420	-	-	ko:K08997	-	-	-	-	ko00000	-	-	-	UPF0061
TLS2_k127_1548103_1	288000.BBta_2927	1.947e-208	668.0	COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,2TRRZ@28211|Alphaproteobacteria,3JTP6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	MA20_16340	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_1548103_4	331869.BAL199_11541	3.598e-77	267.0	COG1024@1|root,COG1024@2|Bacteria,1RBS6@1224|Proteobacteria,2U6UN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_1548103_3	1242864.D187_007030	2.011e-119	396.0	COG1680@1|root,COG1680@2|Bacteria,1QUYZ@1224|Proteobacteria,42PUC@68525|delta/epsilon subdivisions,2WK0V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_1548103_2	1121861.KB899911_gene1418	6.142e-160	509.0	COG1633@1|root,COG1633@2|Bacteria,1MUET@1224|Proteobacteria,2TQMZ@28211|Alphaproteobacteria,2JVZC@204441|Rhodospirillales	204441|Rhodospirillales	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
TLS2_k127_1548103_0	1038859.AXAU01000012_gene4301	7.942e-210	659.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2TS48@28211|Alphaproteobacteria,3K6ZE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_1548103_5	1267005.KB911256_gene1473	3.574e-10	62.0	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2U5HG@28211|Alphaproteobacteria,3N8ED@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Ferric reductase like transmembrane component	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
TLS2_k127_1578220_0	1267005.KB911260_gene3445	5.301e-239	754.0	2A2JU@1|root,30QXU@2|Bacteria,1N7N4@1224|Proteobacteria,2TTU2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_08245	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1578220_4	331869.BAL199_22212	5.093e-95	318.0	COG0640@1|root,COG0640@2|Bacteria,1MWCW@1224|Proteobacteria,2TTA5@28211|Alphaproteobacteria,4BS1P@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_1578220_1	331869.BAL199_22217	5.409e-150	485.0	COG0477@1|root,COG2814@2|Bacteria,1N7AK@1224|Proteobacteria,2TUVF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_1578220_3	1267005.KB911255_gene2613	4.458e-99	329.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2TQXM@28211|Alphaproteobacteria,3N6FU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
TLS2_k127_1578220_2	717785.HYPMC_4688	9.547e-140	451.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2TQTH@28211|Alphaproteobacteria,3N64D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS2_k127_1582291_0	1411123.JQNH01000001_gene2283	4.028e-154	508.0	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,2TS9Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ABC transporter	MA20_43525	-	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2,ABC_tran
TLS2_k127_1582291_1	1230476.C207_01139	1.212e-119	397.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TU4F@28211|Alphaproteobacteria,3JQPK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	FMN-dependent dehydrogenase	MA20_37755	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FMN_dh
TLS2_k127_1582291_2	670307.HYPDE_39423	5.853e-40	149.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2TQU6@28211|Alphaproteobacteria,3N6CH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Mg chelatase subunit ChlI	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
TLS2_k127_1592117_5	685778.AORL01000010_gene3093	4.774e-08	55.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2K02H@204457|Sphingomonadales	204457|Sphingomonadales	V	Efflux pump membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TLS2_k127_1592117_2	1267005.KB911256_gene2092	7.847e-91	308.0	COG0647@1|root,COG0647@2|Bacteria,1MU9Y@1224|Proteobacteria,2TUH0@28211|Alphaproteobacteria,3N6SE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Haloacid dehalogenase-like hydrolase	MA20_05625	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
TLS2_k127_1592117_1	582899.Hden_1668	1.8e-138	451.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2TS2H@28211|Alphaproteobacteria,3N83R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Bacterial lipid A biosynthesis acyltransferase	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
TLS2_k127_1592117_3	582899.Hden_1668	6.093e-84	292.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2TS2H@28211|Alphaproteobacteria,3N83R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Bacterial lipid A biosynthesis acyltransferase	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
TLS2_k127_1592117_0	717785.HYPMC_1941	1.388e-186	587.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TU4H@28211|Alphaproteobacteria,3N866@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the HpcH HpaI aldolase family	mcl1	GO:0003674,GO:0003824,GO:0005488,GO:0016829,GO:0016830,GO:0016833,GO:0043167,GO:0043169,GO:0046872,GO:0047777,GO:0050083	4.1.3.24,4.1.3.25,4.1.3.34	ko:K01644,ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01120,map01200,map02020	M00346,M00373,M00376	R00237,R00362,R00473,R00934	RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_1592117_4	1502851.FG93_01647	3.377e-33	138.0	COG4122@1|root,COG4122@2|Bacteria,1RKBS@1224|Proteobacteria,2UE6R@28211|Alphaproteobacteria,3K26X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
TLS2_k127_1594141_0	1038858.AXBA01000001_gene3521	0.0	1643.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3EYWM@335928|Xanthobacteraceae	28211|Alphaproteobacteria	V	Protein export membrane protein	MA20_26850	-	-	ko:K18299,ko:K18902	-	M00641,M00698	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.16	-	-	ACR_tran
TLS2_k127_1594141_1	420662.Mpe_A0869	5.648e-130	430.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VHW3@28216|Betaproteobacteria,1KMY5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	bepF	-	-	ko:K18901	-	M00698	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TLS2_k127_1594141_2	717785.HYPMC_3778	6.444e-67	231.0	COG1309@1|root,COG1309@2|Bacteria,1NCEF@1224|Proteobacteria,2TR7K@28211|Alphaproteobacteria,3N7F6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
TLS2_k127_1611089_7	1267005.KB911255_gene2898	6.879e-11	62.0	COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,2TQJD@28211|Alphaproteobacteria,3N6FD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	binding-protein-dependent transport systems inner membrane component	yejB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944	-	ko:K13894	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
TLS2_k127_1611089_1	717785.HYPMC_0626	3.981e-183	579.0	COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,2TR1Y@28211|Alphaproteobacteria,3N6JC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	yejE	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944	-	ko:K13895	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1,OppC_N
TLS2_k127_1611089_0	717785.HYPMC_0625	1.973e-247	788.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,3N6DD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	yejF	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02031,ko:K02032,ko:K13896	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	ABC_tran,oligo_HPY
TLS2_k127_1611089_4	582899.Hden_3370	2.408e-124	404.0	COG0583@1|root,COG0583@2|Bacteria,1MV5N@1224|Proteobacteria,2TRAX@28211|Alphaproteobacteria,3N6I8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	MA20_05050	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_1611089_2	1267005.KB911255_gene2615	2.12e-162	516.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2TRBW@28211|Alphaproteobacteria,3N64I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_1611089_5	331869.BAL199_29320	5.959e-119	404.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,4BQDW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0747 ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_1611089_6	582899.Hden_0421	6.477e-71	245.0	COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,2U1XJ@28211|Alphaproteobacteria,3N8I2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,DLH,Thioesterase
TLS2_k127_1611089_3	883078.HMPREF9695_02679	1.779e-150	486.0	COG2271@1|root,COG2271@2|Bacteria,1NJTU@1224|Proteobacteria,2TUBJ@28211|Alphaproteobacteria,3JU19@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	MA20_01130	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_166916_2	1187851.A33M_4469	3.673e-249	790.0	COG5316@1|root,COG5316@2|Bacteria,1NWFX@1224|Proteobacteria,2U10J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
TLS2_k127_166916_6	1267005.KB911256_gene1900	8.129e-161	553.0	COG2982@1|root,COG2982@2|Bacteria,1MUNH@1224|Proteobacteria,2TT0W@28211|Alphaproteobacteria,3N7AH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	AsmA family	asmA	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
TLS2_k127_166916_8	1122132.AQYH01000005_gene515	9.687e-105	346.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2TSUR@28211|Alphaproteobacteria,4BAAW@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
TLS2_k127_166916_13	402881.Plav_0190	9.162e-57	202.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2U7B0@28211|Alphaproteobacteria,1JP3P@119043|Rhodobiaceae	28211|Alphaproteobacteria	GT	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
TLS2_k127_166916_14	937777.Deipe_2746	1.402e-37	151.0	COG0824@1|root,COG0824@2|Bacteria	2|Bacteria	IQ	Thioesterase	ysmA	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2,Acetyltransf_10
TLS2_k127_166916_9	1267005.KB911259_gene3695	9.399e-97	332.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2TR70@28211|Alphaproteobacteria,3N6TI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
TLS2_k127_166916_12	1040982.AXAL01000001_gene1891	3.606e-68	235.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,2U75W@28211|Alphaproteobacteria,43JPW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
TLS2_k127_166916_3	1116369.KB890024_gene1707	4.899e-225	703.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,43HT5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TLS2_k127_166916_7	1187851.A33M_0653	2.577e-156	496.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TRI8@28211|Alphaproteobacteria,3FCRV@34008|Rhodovulum	28211|Alphaproteobacteria	O	AAA domain (Cdc48 subfamily)	MA20_01295	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
TLS2_k127_166916_4	670307.HYPDE_34623	6.193e-205	646.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,2TR6W@28211|Alphaproteobacteria,3N68X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TLS2_k127_166916_11	1429916.X566_08540	3.376e-70	243.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,2U71H@28211|Alphaproteobacteria,3JRP0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
TLS2_k127_166916_1	670307.HYPDE_34603	9.476e-312	962.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria,3N68W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
TLS2_k127_166916_5	717785.HYPMC_1115	1.058e-165	531.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria,3N61F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Peptidogalycan biosysnthesis/recognition	MA20_36195	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
TLS2_k127_166916_10	1380394.JADL01000012_gene950	1.057e-95	322.0	COG2084@1|root,COG2084@2|Bacteria,1MV48@1224|Proteobacteria,2U0FZ@28211|Alphaproteobacteria,2JR1E@204441|Rhodospirillales	204441|Rhodospirillales	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_166916_15	717785.HYPMC_0564	1.79e-26	117.0	COG1493@1|root,COG1493@2|Bacteria	2|Bacteria	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	hprK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
TLS2_k127_166916_0	1211115.ALIQ01000140_gene1266	2.887e-315	974.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,3NC6A@45404|Beijerinckiaceae	28211|Alphaproteobacteria	EG	Dehydratase family	MA20_27195	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS2_k127_166916_16	1461694.ATO9_01340	2.863e-17	85.0	COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,2TVRD@28211|Alphaproteobacteria,2PFWU@252301|Oceanicola	28211|Alphaproteobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
TLS2_k127_1701138_6	1443111.JASG01000004_gene569	3.374e-16	85.0	COG0412@1|root,COG1167@1|root,COG0412@2|Bacteria,COG1167@2|Bacteria	2|Bacteria	K	transaminase activity	msi124	-	3.1.1.45	ko:K00375,ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000,ko03000	-	-	-	Aminotran_1_2,DLH,GntR
TLS2_k127_1701138_5	1267005.KB911263_gene1389	8.517e-37	147.0	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VG8N@28211|Alphaproteobacteria,3N8XB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
TLS2_k127_1701138_4	1267005.KB911263_gene1388	7.459e-62	224.0	COG3577@1|root,COG3577@2|Bacteria,1MZCI@1224|Proteobacteria,2U9K2@28211|Alphaproteobacteria,3N7AR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	gag-polyprotein putative aspartyl protease	MA20_25915	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	Asp_protease_2,gag-asp_proteas
TLS2_k127_1701138_7	426117.M446_4380	3.871e-12	69.0	COG3313@1|root,COG3313@2|Bacteria,1NGD5@1224|Proteobacteria,2UJKX@28211|Alphaproteobacteria,1JW5Y@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1289)	-	-	-	ko:K06938	-	-	-	-	ko00000	-	-	-	DUF1289
TLS2_k127_1701138_0	582899.Hden_1862	6.572e-184	592.0	COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,2TYNJ@28211|Alphaproteobacteria,3N67B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07716	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,dCache_1
TLS2_k127_1701138_2	1381123.AYOD01000002_gene632	3.126e-83	283.0	COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria,2U5IH@28211|Alphaproteobacteria,43I1H@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
TLS2_k127_1701138_3	648885.KB316283_gene3210	2.596e-81	277.0	COG1234@1|root,COG1234@2|Bacteria,1Q4PW@1224|Proteobacteria,2TUHQ@28211|Alphaproteobacteria,1JTUY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM beta-lactamase domain protein	MA20_22080	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_1701138_1	1120792.JAFV01000001_gene3141	1.045e-90	319.0	COG1573@1|root,COG1573@2|Bacteria,1R9XV@1224|Proteobacteria,2TSWU@28211|Alphaproteobacteria,36Y6Q@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_1701138_8	670307.HYPDE_36623	0.0001929	48.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,3N67I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
TLS2_k127_1710127_6	1040989.AWZU01000024_gene6482	1.335e-60	218.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,3JR5S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Beta-lactamase	MA20_00470	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_1710127_2	1298867.AUES01000017_gene3976	4.021e-113	381.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,3JR5S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Beta-lactamase	MA20_00470	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_1710127_4	1267005.KB911257_gene1051	3.48e-107	356.0	2EY8I@1|root,33RH3@2|Bacteria,1NS5H@1224|Proteobacteria,2UP0R@28211|Alphaproteobacteria,3N86N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1710127_1	1267005.KB911257_gene762	1.206e-186	587.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria,3N6JG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_1710127_0	1267005.KB911256_gene1846	4.259e-231	724.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2TQQ4@28211|Alphaproteobacteria,3N6DA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b
TLS2_k127_1710127_3	1267005.KB911257_gene698	1.673e-108	360.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,3N6FQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_1710127_10	666684.AfiDRAFT_2786	1.071e-05	56.0	2EGX7@1|root,33APC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1710127_7	570967.JMLV01000006_gene346	2.864e-30	127.0	COG0679@1|root,COG0679@2|Bacteria,1PINE@1224|Proteobacteria,2TUJR@28211|Alphaproteobacteria,2JRTP@204441|Rhodospirillales	204441|Rhodospirillales	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
TLS2_k127_1710127_5	1267005.KB911260_gene3437	1.166e-90	305.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2TQXZ@28211|Alphaproteobacteria,3N6VV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
TLS2_k127_1710127_8	1089552.KI911559_gene674	1.824e-20	93.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TSD9@28211|Alphaproteobacteria,2JQUN@204441|Rhodospirillales	204441|Rhodospirillales	K	LysR substrate binding domain	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
TLS2_k127_1874033_6	331869.BAL199_24464	1.675e-30	121.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSA6@28211|Alphaproteobacteria,4BT78@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	MA20_02445	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_1874033_0	1207063.P24_16360	2.03e-120	393.0	COG0559@1|root,COG0559@2|Bacteria,1R5H9@1224|Proteobacteria,2TUJ6@28211|Alphaproteobacteria,2JVT7@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
TLS2_k127_1874033_1	1207063.P24_16355	1.125e-103	345.0	COG4177@1|root,COG4177@2|Bacteria,1PAW4@1224|Proteobacteria,2U0EY@28211|Alphaproteobacteria,2JZAV@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
TLS2_k127_1874033_5	582899.Hden_2894	3.144e-59	209.0	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2U6ZN@28211|Alphaproteobacteria,3N71K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Redoxin	MA20_20905	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	Redoxin
TLS2_k127_1874033_4	1267005.KB911255_gene2975	5.805e-64	233.0	COG4123@1|root,COG4123@2|Bacteria,1MXEQ@1224|Proteobacteria,2TUBR@28211|Alphaproteobacteria,3N6VC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Methyltransferase small domain	yfiC	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS
TLS2_k127_1874033_7	582899.Hden_2867	1.08e-18	89.0	2E3KZ@1|root,32YJ8@2|Bacteria,1N7A7@1224|Proteobacteria,2UFMR@28211|Alphaproteobacteria,3N9CD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative prokaryotic signal transducing protein	MA20_42240	-	-	-	-	-	-	-	-	-	-	-	DUF2007
TLS2_k127_1874033_3	1298867.AUES01000032_gene2002	5.61e-84	284.0	COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,2U07P@28211|Alphaproteobacteria,3K0C4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	DSBA-like thioredoxin domain	nahD	-	-	-	-	-	-	-	-	-	-	-	DSBA
TLS2_k127_1874033_2	1040989.AWZU01000020_gene1977	3.467e-98	327.0	COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,2UVAZ@28211|Alphaproteobacteria,3JRFH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the 3-hydroxyisobutyrate dehydrogenase family	mmsB	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_1908890_5	648757.Rvan_3530	6.847e-168	534.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2TSVJ@28211|Alphaproteobacteria,3N61S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Sodium Bile acid symporter family	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
TLS2_k127_1908890_2	316058.RPB_1643	7.714e-206	646.0	COG0477@1|root,COG2814@2|Bacteria,1MV8D@1224|Proteobacteria,2TT4B@28211|Alphaproteobacteria,3JWYY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_1908890_3	1121106.JQKB01000093_gene1811	2.547e-193	608.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TU32@28211|Alphaproteobacteria,2JQWP@204441|Rhodospirillales	204441|Rhodospirillales	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TLS2_k127_1908890_12	1197906.CAJQ02000011_gene934	6.001e-96	322.0	COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,1MWYQ@1224|Proteobacteria,2TU1U@28211|Alphaproteobacteria,3K30K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	KT	Low molecular weight phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	HTH_20,LMWPc
TLS2_k127_1908890_6	414684.RC1_3527	5.555e-164	531.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2JPCT@204441|Rhodospirillales	204441|Rhodospirillales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_1908890_15	314256.OG2516_06479	3.081e-59	212.0	COG1309@1|root,COG1309@2|Bacteria,1PESV@1224|Proteobacteria,2VCU8@28211|Alphaproteobacteria,2PFW3@252301|Oceanicola	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_1908890_4	1336243.JAEA01000006_gene496	2.323e-168	538.0	COG0683@1|root,COG0683@2|Bacteria,1N1MX@1224|Proteobacteria,2TSIX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	MA20_23475	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_1908890_11	1121920.AUAU01000008_gene1546	1.492e-107	353.0	COG0411@1|root,COG0411@2|Bacteria	2|Bacteria	E	ABC transporter	MA20_23480	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_1908890_10	1121920.AUAU01000008_gene1545	2.09e-109	361.0	COG0410@1|root,COG0410@2|Bacteria,3Y9ED@57723|Acidobacteria	2|Bacteria	E	ABC transporter	livF_1	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_1908890_9	1500894.JQNN01000001_gene616	6.499e-124	406.0	COG0559@1|root,COG0559@2|Bacteria,1MVZ5@1224|Proteobacteria,2VJCG@28216|Betaproteobacteria,478G9@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_1908890_8	864069.MicloDRAFT_00047580	1.527e-144	467.0	COG4177@1|root,COG4177@2|Bacteria,1MZDJ@1224|Proteobacteria,2TRYJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	MA20_23495	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_1908890_14	1122962.AULH01000001_gene1433	2.627e-85	287.0	COG5482@1|root,COG5482@2|Bacteria,1MWIN@1224|Proteobacteria,2TS4R@28211|Alphaproteobacteria,36YVV@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Putative PD-(D/E)XK phosphodiesterase (DUF2161)	MA20_28540	-	-	-	-	-	-	-	-	-	-	-	DUF2161
TLS2_k127_1908890_16	1121403.AUCV01000002_gene474	1.059e-42	160.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	hom	-	1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19	ko:K00003,ko:K00058,ko:K01754,ko:K04767	ko00260,ko00270,ko00290,ko00300,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00017,M00018,M00020,M00570	R00220,R00996,R01513,R01773,R01775	RC00031,RC00087,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3
TLS2_k127_1908890_17	266779.Meso_2460	3.743e-13	73.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CMAS,Methyltransf_11,Methyltransf_25
TLS2_k127_1908890_13	1038859.AXAU01000026_gene2345	5.698e-89	302.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TVV1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_1908890_7	331869.BAL199_17738	1.069e-158	509.0	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,2U0E0@28211|Alphaproteobacteria,4BQRH@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_1908890_0	1267005.KB911256_gene1817	4.477e-226	711.0	COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,3N6F3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	glutamate--cysteine ligase	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
TLS2_k127_1908890_1	582899.Hden_2305	2.358e-208	650.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2TSJY@28211|Alphaproteobacteria,3N631@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS2_k127_1919187_2	1267005.KB911261_gene2259	4.151e-188	591.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria,3N6C4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
TLS2_k127_1919187_0	1267005.KB911261_gene2258	0.0	2337.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria,3N66K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
TLS2_k127_1919187_3	717785.HYPMC_1020	6.214e-109	364.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2TTMG@28211|Alphaproteobacteria,3N6U8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TLS2_k127_1919187_1	717785.HYPMC_1019	0.0	1043.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,3N6HX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TLS2_k127_1919187_5	388739.RSK20926_01742	6.912e-30	131.0	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2U6K4@28211|Alphaproteobacteria,2P2WV@2433|Roseobacter	28211|Alphaproteobacteria	T	COG0631 Serine threonine protein phosphatase	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
TLS2_k127_1919187_4	1207063.P24_12422	3.425e-43	161.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2TS2D@28211|Alphaproteobacteria,2JQ4D@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
TLS2_k127_1936109_2	316055.RPE_4908	4.444e-73	254.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria,3JUVR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Iron-containing alcohol dehydrogenase	MA20_22910	-	1.3.1.32	ko:K00217	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	-	R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224	RC00107,RC01335,RC01689,RC02442	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
TLS2_k127_1936109_0	1411123.JQNH01000001_gene2683	6.646e-163	522.0	COG0477@1|root,COG2814@2|Bacteria,1MX2P@1224|Proteobacteria,2TWIP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_1936109_5	717785.HYPMC_0959	3.945e-34	137.0	2C2M3@1|root,316DE@2|Bacteria,1R7TZ@1224|Proteobacteria,2UB1Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_16080	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1936109_4	717785.HYPMC_2201	9.123e-36	138.0	COG5501@1|root,COG5501@2|Bacteria,1N03V@1224|Proteobacteria,2TWQY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oxidation protein (SoxZ)	MA20_17515	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxZ
TLS2_k127_1936109_3	1197906.CAJQ02000022_gene4232	1.755e-36	145.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2U72E@28211|Alphaproteobacteria,3JYQN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sulfur oxidation protein SoxY	soxY	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
TLS2_k127_1936109_8	439497.RR11_641	2.022e-20	97.0	COG0526@1|root,COG0526@2|Bacteria,1MZH0@1224|Proteobacteria,2UCBJ@28211|Alphaproteobacteria,4NCIJ@97050|Ruegeria	28211|Alphaproteobacteria	CO	Regulatory protein SoxS	soxS	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1936109_1	717785.HYPMC_2198	8.3e-134	440.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2TT55@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Sulfide dehydrogenase	fccB	-	1.8.2.3,1.8.5.4	ko:K17218,ko:K17229	ko00920,ko01120,map00920,map01120	-	R09499,R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2
TLS2_k127_1936109_6	991905.SL003B_0240	2.58e-33	131.0	COG2154@1|root,COG2154@2|Bacteria,1MZ5Q@1224|Proteobacteria,2UBWN@28211|Alphaproteobacteria,4BQU7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Pterin 4 alpha carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
TLS2_k127_1936109_7	1038862.KB893850_gene6951	4.204e-26	108.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,3JTEV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TLS2_k127_1956715_1	743836.AYNA01000068_gene351	6.081e-57	222.0	2EFE7@1|root,33970@2|Bacteria,1N7BW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1956715_0	1121861.KB899912_gene987	2.141e-173	554.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSMN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	MA20_03535	-	1.1.1.29,1.1.1.399,1.1.1.95	ko:K00018,ko:K00058	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020,M00346	R00717,R01388,R01513	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_1965586_2	582899.Hden_2305	1.715e-86	287.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2TSJY@28211|Alphaproteobacteria,3N631@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS2_k127_1965586_1	648757.Rvan_1921	5.451e-147	472.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2TRW7@28211|Alphaproteobacteria,3N6P5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	MA20_42175	-	-	ko:K19745	ko00640,ko01100,map00640,map01100	-	R00919	RC00095	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_1965586_3	1267005.KB911255_gene2755	4.182e-50	189.0	COG3772@1|root,COG3772@2|Bacteria	2|Bacteria	S	cytolysis by virus of host cell	-	-	3.2.1.17	ko:K01185	-	-	-	-	ko00000,ko01000	-	-	-	PG_binding_1,Phage_lysozyme
TLS2_k127_1965586_7	717785.HYPMC_4329	1.443e-26	112.0	2EI58@1|root,33BWK@2|Bacteria,1NMVP@1224|Proteobacteria,2UKIB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1965586_10	426355.Mrad2831_1695	9.873e-15	80.0	2D2MA@1|root,32TD2@2|Bacteria,1N2AM@1224|Proteobacteria,2TT4S@28211|Alphaproteobacteria,1JVIY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	MA20_00435	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1965586_14	316056.RPC_1122	1.078e-08	63.0	2EM3Y@1|root,33ETF@2|Bacteria,1N905@1224|Proteobacteria,2UH6P@28211|Alphaproteobacteria,3JYFK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1965586_12	1336243.JAEA01000009_gene230	5.743e-10	66.0	COG3951@1|root,COG3951@2|Bacteria,1N71D@1224|Proteobacteria,2UGMZ@28211|Alphaproteobacteria,1JW0B@119045|Methylobacteriaceae	28211|Alphaproteobacteria	MNO	Rod binding protein	flgJ	-	-	-	-	-	-	-	-	-	-	-	Rod-binding
TLS2_k127_1965586_4	935840.JAEQ01000001_gene3144	6.467e-43	169.0	COG1684@1|root,COG1684@2|Bacteria,1REDJ@1224|Proteobacteria,2U70N@28211|Alphaproteobacteria,43HBG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	N	Role in flagellar biosynthesis	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
TLS2_k127_1965586_0	1211115.ALIQ01000185_gene3163	1.071e-287	900.0	COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,2TQUR@28211|Alphaproteobacteria,3NACJ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	NU	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
TLS2_k127_1965586_9	419610.Mext_0689	2.374e-21	104.0	COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,2UBX6@28211|Alphaproteobacteria,1JVW5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	N	Flagellar biosynthetic protein FliQ	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
TLS2_k127_1965586_6	1041139.KB902578_gene5594	1.275e-26	116.0	COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,2UCHH@28211|Alphaproteobacteria,4BFC7@82115|Rhizobiaceae	28211|Alphaproteobacteria	N	Flagellar hook capping protein	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgD
TLS2_k127_1965586_5	314231.FP2506_12769	4.95e-36	142.0	COG5443@1|root,COG5443@2|Bacteria,1MZE2@1224|Proteobacteria,2UCMW@28211|Alphaproteobacteria,2PM4A@255475|Aurantimonadaceae	28211|Alphaproteobacteria	N	Flagellar protein FlbT	flbT	-	-	ko:K06601	-	-	-	-	ko00000,ko02035	-	-	-	FlbT
TLS2_k127_1965586_8	1211115.ALIQ01000185_gene3167	6.182e-24	105.0	COG5442@1|root,COG5442@2|Bacteria,1N223@1224|Proteobacteria,2UE82@28211|Alphaproteobacteria,3NBNP@45404|Beijerinckiaceae	28211|Alphaproteobacteria	N	Flagellar protein FlaF	flaF	-	-	ko:K06602	-	-	-	-	ko00000,ko02035	-	-	-	FlaF
TLS2_k127_1965586_15	1192868.CAIU01000025_gene3583	9.838e-08	55.0	COG1344@1|root,COG1344@2|Bacteria,1MVTB@1224|Proteobacteria,2TVAK@28211|Alphaproteobacteria,43H84@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
TLS2_k127_2001236_13	1185652.USDA257_c18320	0.0009065	44.0	COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,2TTCA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0076 Glutamate decarboxylase and related PLP-dependent proteins	-	-	4.1.2.27	ko:K01634	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00100	R02464,R06516	RC00264,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
TLS2_k127_2001236_9	1305735.JAFT01000005_gene2327	1.952e-55	204.0	COG1414@1|root,COG1414@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS2_k127_2001236_3	935840.JAEQ01000001_gene2892	7.097e-181	579.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2TU3I@28211|Alphaproteobacteria,43HT7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Cytochrome BD ubiquinol oxidase subunit II	-	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
TLS2_k127_2001236_1	935840.JAEQ01000001_gene2893	1.703e-261	811.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria,43IEC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	oxidase, subunit	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
TLS2_k127_2001236_6	1028800.RG540_CH19420	6.046e-91	317.0	COG2159@1|root,COG2159@2|Bacteria,1MXI7@1224|Proteobacteria,2U15G@28211|Alphaproteobacteria,4B8SX@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	4.1.1.46	ko:K07045,ko:K14333,ko:K15063	ko00362,ko00627,ko01120,map00362,map00627,map01120	-	R00821,R09278	RC00390	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
TLS2_k127_2001236_11	420324.KI912045_gene4194	7.798e-49	177.0	COG0662@1|root,COG0662@2|Bacteria,1RICR@1224|Proteobacteria,2U9S9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2001236_4	935557.ATYB01000008_gene5432	2.33e-168	533.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria,4B9IS@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	NMT1-like family	thyA	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
TLS2_k127_2001236_0	420324.KI911965_gene1316	0.0	1262.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system fused permease components	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
TLS2_k127_2001236_2	1380394.JADL01000004_gene5920	3.276e-218	695.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TSME@28211|Alphaproteobacteria,2JQW6@204441|Rhodospirillales	204441|Rhodospirillales	E	Gamma-glutamyltranspeptidase	-	-	-	-	-	-	-	-	-	-	-	-	G_glu_transpept
TLS2_k127_2001236_10	420324.KI912079_gene8214	4.094e-55	208.0	COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,2UC7A@28211|Alphaproteobacteria,1JY94@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1428)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1428
TLS2_k127_2001236_7	1380387.JADM01000012_gene1528	4.3e-71	248.0	COG0625@1|root,COG0625@2|Bacteria,1PENB@1224|Proteobacteria,1SBMB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	PFAM Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
TLS2_k127_2001236_5	420324.KI912045_gene4391	6.283e-101	332.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,2TQMU@28211|Alphaproteobacteria,1JRE6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	KO	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG	ureG	-	-	ko:K03189	-	-	-	-	ko00000	-	-	-	cobW
TLS2_k127_2001236_8	1207063.P24_12282	9.39e-65	231.0	COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,2TRVW@28211|Alphaproteobacteria,2JS3Y@204441|Rhodospirillales	204441|Rhodospirillales	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureF	-	-	ko:K03188	-	-	-	-	ko00000	-	-	-	UreF
TLS2_k127_2001236_12	1211115.ALIQ01000218_gene1476	2.605e-39	153.0	COG2371@1|root,COG2371@2|Bacteria,1MZQZ@1224|Proteobacteria,2TVBW@28211|Alphaproteobacteria,3NBRN@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly	ureE	-	-	ko:K03187	-	-	-	-	ko00000	-	-	-	UreE_C,UreE_N
TLS2_k127_2009126_25	1532557.JL37_27115	6.053e-09	64.0	COG1028@1|root,COG1028@2|Bacteria,1Q7EW@1224|Proteobacteria,2VJX4@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100,1.1.1.47	ko:K00034,ko:K00059	ko00030,ko00061,ko00333,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00030,map00061,map00333,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00572	R01520,R01521,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00066,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
TLS2_k127_2009126_20	1205680.CAKO01000037_gene1232	3.108e-54	198.0	COG3917@1|root,COG3917@2|Bacteria,1R3XW@1224|Proteobacteria,2TUW5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
TLS2_k127_2009126_8	1137269.AZWL01000001_gene5348	5.816e-125	419.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_2009126_4	1207063.P24_18716	4.571e-179	571.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,2JTNS@204441|Rhodospirillales	204441|Rhodospirillales	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
TLS2_k127_2009126_13	398525.KB900701_gene6413	2.795e-109	360.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2TSWQ@28211|Alphaproteobacteria,3JUT4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	MA20_14905	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_2009126_15	1304878.AUGD01000006_gene6567	6.054e-101	337.0	COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2VEYC@28211|Alphaproteobacteria,3JVET@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	AAA domain	MA20_14910	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_2009126_7	1038866.KB902768_gene5086	8.588e-127	414.0	COG4177@1|root,COG4177@2|Bacteria,1N5I8@1224|Proteobacteria,2U0PT@28211|Alphaproteobacteria,3JSC7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	MA20_14915	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_2009126_9	1038866.KB902768_gene5085	1.366e-124	406.0	COG0559@1|root,COG0559@2|Bacteria,1Q7SN@1224|Proteobacteria,2TVPA@28211|Alphaproteobacteria,3JTH7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	MA20_14920	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_2009126_2	1038859.AXAU01000017_gene6383	6.74e-206	650.0	COG0683@1|root,COG0683@2|Bacteria,1MVZR@1224|Proteobacteria,2TRRP@28211|Alphaproteobacteria,3JTVJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein domain	MA20_14925	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_2009126_19	1207063.P24_18721	1.661e-58	217.0	COG1309@1|root,COG1309@2|Bacteria,1RE97@1224|Proteobacteria,2U8N9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	MA20_14935	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_2009126_12	1392838.AWNM01000097_gene113	1.663e-109	362.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2VN57@28216|Betaproteobacteria,3T3MW@506|Alcaligenaceae	28216|Betaproteobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS2_k127_2009126_6	1207063.P24_08069	8.682e-154	492.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,2JR4B@204441|Rhodospirillales	204441|Rhodospirillales	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_2009126_14	766499.C357_02319	1.864e-107	353.0	COG1024@1|root,COG1024@2|Bacteria,1MXEN@1224|Proteobacteria,2TTIH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_2009126_22	1123072.AUDH01000001_gene2786	9.388e-39	158.0	COG0508@1|root,COG0508@2|Bacteria,1R960@1224|Proteobacteria,2UPDP@28211|Alphaproteobacteria,2JWCE@204441|Rhodospirillales	204441|Rhodospirillales	C	e3 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_2009126_3	266265.Bxe_C0852	5.391e-181	575.0	COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2VKD1@28216|Betaproteobacteria,1JZRA@119060|Burkholderiaceae	1224|Proteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_2009126_1	1298867.AUES01000006_gene289	2.716e-224	705.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JTDD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	MA20_18835	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_2009126_16	666684.AfiDRAFT_2788	5.339e-94	321.0	COG4948@1|root,COG4948@2|Bacteria,1RA2C@1224|Proteobacteria,2U5VX@28211|Alphaproteobacteria,3JZ33@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C
TLS2_k127_2009126_21	574087.Acear_0477	1.986e-47	176.0	COG2185@1|root,COG2185@2|Bacteria,1V45Q@1239|Firmicutes,24HGC@186801|Clostridia,3WBPB@53433|Halanaerobiales	186801|Clostridia	I	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	mamA	-	5.4.99.1	ko:K01846	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
TLS2_k127_2009126_10	868595.Desca_0602	6.609e-121	404.0	COG0849@1|root,COG0849@2|Bacteria,1TQC5@1239|Firmicutes,24BFJ@186801|Clostridia,2605E@186807|Peptococcaceae	186801|Clostridia	D	TIGRFAM conserved	mutL2	-	-	-	-	-	-	-	-	-	-	-	MutL
TLS2_k127_2009126_11	1120985.AUMI01000011_gene68	1.278e-119	404.0	COG4865@1|root,COG4865@2|Bacteria,1TS6B@1239|Firmicutes,4H397@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	glmE	-	5.4.99.1	ko:K19268	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_asp_mut_E
TLS2_k127_2009126_24	1089552.KI911559_gene394	9.851e-19	94.0	COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,2U5AP@28211|Alphaproteobacteria,2JRP6@204441|Rhodospirillales	204441|Rhodospirillales	EH	Reduction of activated sulfate into sulfite	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TLS2_k127_2009126_23	640512.BC1003_1108	1.52e-35	145.0	COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,2VN1A@28216|Betaproteobacteria,1K38D@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	cpdA	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
TLS2_k127_2009126_0	1096769.Pelub83DRAFT_0317	0.0	1040.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2TSN4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	succinate dehydrogenase fumarate reductase, flavoprotein subunit	MA20_14860	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_2009126_18	1096769.Pelub83DRAFT_0318	8.843e-68	233.0	COG1146@1|root,COG1146@2|Bacteria,1R4GP@1224|Proteobacteria	1224|Proteobacteria	C	reductase, beta subunit	aprB	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS-reductase_C,Fer4,Fer4_9
TLS2_k127_2009126_17	713587.THITH_01405	8.877e-86	291.0	2BX2I@1|root,2Z9KR@2|Bacteria,1MXKC@1224|Proteobacteria,1RRV2@1236|Gammaproteobacteria,1WXVA@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2009126_5	396588.Tgr7_0353	1.302e-164	527.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales	135613|Chromatiales	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
TLS2_k127_2009126_26	765912.Thimo_2659	5.153e-05	47.0	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1WY4B@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TLS2_k127_2029465_7	935840.JAEQ01000033_gene2389	8.878e-75	252.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
TLS2_k127_2029465_11	1267005.KB911255_gene2387	3.571e-06	52.0	COG1961@1|root,COG1961@2|Bacteria,1PWCY@1224|Proteobacteria,2TVME@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_2029465_5	1429916.X566_02405	1.763e-101	339.0	COG1028@1|root,COG1028@2|Bacteria,1MW46@1224|Proteobacteria,2TUTU@28211|Alphaproteobacteria,3JVSJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	MA20_15935	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_2029465_10	1231185.BAMP01000037_gene641	9.878e-12	69.0	2E3JP@1|root,2ZYM9@2|Bacteria,1PM8P@1224|Proteobacteria,2UZW1@28211|Alphaproteobacteria,43QJ4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2783)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2783
TLS2_k127_2029465_1	1231190.NA8A_17128	1.319e-219	694.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2TQT8@28211|Alphaproteobacteria,43I8B@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	CH	FAD-dependent oxidoreductase	MA20_39380	-	1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
TLS2_k127_2029465_4	1381123.AYOD01000064_gene1531	3.241e-170	543.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2TQUY@28211|Alphaproteobacteria,43JD1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	MA20_39390	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_2029465_0	1144343.PMI41_02975	1.674e-236	739.0	COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2TRFI@28211|Alphaproteobacteria,43J5X@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
TLS2_k127_2029465_8	1267005.KB911255_gene3025	8.181e-62	224.0	2APUG@1|root,31EYZ@2|Bacteria,1R3K7@1224|Proteobacteria,2U03X@28211|Alphaproteobacteria,3N8V4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
TLS2_k127_2029465_6	1267005.KB911255_gene3028	9.008e-87	293.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2TR0A@28211|Alphaproteobacteria,3N6MW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	ptr1	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
TLS2_k127_2029465_9	1177928.TH2_00015	2.427e-25	110.0	COG1539@1|root,COG1539@2|Bacteria,1MY5Q@1224|Proteobacteria,2TRVX@28211|Alphaproteobacteria,2JTB7@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
TLS2_k127_2029465_2	1267005.KB911257_gene742	9.41e-213	667.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2TRXC@28211|Alphaproteobacteria,3N6AM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
TLS2_k127_2029465_3	1297863.APJF01000022_gene4460	1.068e-211	669.0	COG1024@1|root,COG1024@2|Bacteria,1N817@1224|Proteobacteria,2TQTE@28211|Alphaproteobacteria,3JTG3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	boxC	-	4.1.2.44	ko:K15513	ko00362,map00362	-	R09556	RC03426	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS2_k127_2044276_4	359.CN09_19995	3.413e-07	53.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
TLS2_k127_2044276_3	1197906.CAJQ02000003_gene3219	1.328e-11	65.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3JUGV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_2044276_2	648757.Rvan_2883	7.301e-63	223.0	COG1664@1|root,COG1664@2|Bacteria,1N702@1224|Proteobacteria,2UN6M@28211|Alphaproteobacteria,3N8DS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Cadherin-like	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin,Cadherin_3
TLS2_k127_2044276_0	1267005.KB911255_gene2388	1.149e-152	501.0	COG4191@1|root,COG4191@2|Bacteria,1MVK7@1224|Proteobacteria,2TR44@28211|Alphaproteobacteria,3N670@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	regM	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_2044276_1	670307.HYPDE_41008	5.102e-133	432.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TU0K@28211|Alphaproteobacteria,3N6QC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	pyridine nucleotide-disulfide oxidoreductase	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_2045302_32	1387197.AWGA01000023_gene1079	1.536e-07	53.0	2EFWG@1|root,339NR@2|Bacteria,1NIWH@1224|Proteobacteria,1SHRN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2045302_23	1449065.JMLL01000012_gene3491	5.737e-42	164.0	COG2374@1|root,COG2374@2|Bacteria,1R22Q@1224|Proteobacteria,2TZ99@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Hint domain	-	-	-	-	-	-	-	-	-	-	-	-	Hint_2
TLS2_k127_2045302_26	323098.Nwi_2599	3.131e-33	133.0	COG2076@1|root,COG2076@2|Bacteria,1MZ54@1224|Proteobacteria,2UBXR@28211|Alphaproteobacteria,3JZ1E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Small Multidrug Resistance protein	emrE	-	-	ko:K03297	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
TLS2_k127_2045302_22	1267005.KB911259_gene3777	5.587e-47	173.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria,3N72F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_2045302_24	1333998.M2A_1941	9.402e-37	145.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,2UBS3@28211|Alphaproteobacteria,4BR07@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	S4 domain	hslR	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
TLS2_k127_2045302_0	1267005.KB911257_gene955	0.0	1273.0	COG4581@1|root,COG4581@2|Bacteria,1MVD6@1224|Proteobacteria,2TR7N@28211|Alphaproteobacteria,3N66S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	helicase superfamily c-terminal domain	mgpS	-	3.6.4.13	ko:K17675	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	Helicase_C
TLS2_k127_2045302_20	1267005.KB911257_gene956	2.806e-51	192.0	COG3064@1|root,COG3064@2|Bacteria,1NAWA@1224|Proteobacteria,2TSQY@28211|Alphaproteobacteria,3N7CW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
TLS2_k127_2045302_27	1227360.C176_07867	4.129e-24	112.0	COG0730@1|root,COG0730@2|Bacteria,1TT6E@1239|Firmicutes,4HC1R@91061|Bacilli,26E3B@186818|Planococcaceae	91061|Bacilli	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_2045302_21	1547437.LL06_04435	3.467e-48	175.0	COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,2U9M1@28211|Alphaproteobacteria,43KFK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Putative member of DMT superfamily (DUF486)	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
TLS2_k127_2045302_30	195105.CN97_19935	1.009e-17	89.0	COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,2UF72@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein affecting phage T7 exclusion by the F plasmid	fxsA	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
TLS2_k127_2045302_17	582899.Hden_3267	6e-78	269.0	COG4395@1|root,COG4395@2|Bacteria,1NCIX@1224|Proteobacteria,2TTDQ@28211|Alphaproteobacteria,3N6W9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	import inner membrane translocase subunit Tim44	MA20_24770	-	-	-	-	-	-	-	-	-	-	-	Tim44
TLS2_k127_2045302_9	1267005.KB911257_gene1000	4.168e-139	455.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2TS5S@28211|Alphaproteobacteria,3N88Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	MltA specific insert domain	mltA	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
TLS2_k127_2045302_25	639283.Snov_3820	1.532e-36	147.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2UCM1@28211|Alphaproteobacteria,3EZKI@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Smr domain	smrA	-	-	-	-	-	-	-	-	-	-	-	Smr
TLS2_k127_2045302_13	414684.RC1_3804	2.213e-107	355.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2TTP8@28211|Alphaproteobacteria,2JPQK@204441|Rhodospirillales	204441|Rhodospirillales	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	prpB	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
TLS2_k127_2045302_18	1122164.JHWF01000024_gene2565	1.142e-73	276.0	COG1409@1|root,COG1409@2|Bacteria,1R4EJ@1224|Proteobacteria,1T7TW@1236|Gammaproteobacteria,1JFUH@118969|Legionellales	118969|Legionellales	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS2_k127_2045302_7	1336208.JADY01000002_gene335	2.492e-148	486.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,2JR12@204441|Rhodospirillales	204441|Rhodospirillales	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
TLS2_k127_2045302_8	1121106.JQKB01000014_gene5629	1.297e-139	451.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2JQBC@204441|Rhodospirillales	204441|Rhodospirillales	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_2045302_11	911045.PSE_0439	1.466e-127	419.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2TT4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_2045302_10	911045.PSE_0438	1.563e-136	442.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR3F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_2045302_6	1502851.FG93_05610	1.09e-207	664.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria,3JVSR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_2045302_28	1123229.AUBC01000015_gene4707	4.366e-23	108.0	COG3108@1|root,COG3108@2|Bacteria,1NEAY@1224|Proteobacteria,2UHRJ@28211|Alphaproteobacteria,3K5R1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_3
TLS2_k127_2045302_5	670307.HYPDE_28553	7.878e-221	694.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,2TSQH@28211|Alphaproteobacteria,3N66I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Amidohydrolase family	pyrC1	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS2_k127_2045302_16	670307.HYPDE_28548	3.595e-79	283.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2TR8J@28211|Alphaproteobacteria,3N6WQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the GcvT family	ygfZ	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
TLS2_k127_2045302_15	717785.HYPMC_2971	5.534e-83	285.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2TUP5@28211|Alphaproteobacteria,3N6ZF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
TLS2_k127_2045302_19	314254.OA2633_14326	1.224e-69	242.0	COG1896@1|root,COG1896@2|Bacteria,1RACF@1224|Proteobacteria,2TUK3@28211|Alphaproteobacteria,43XDG@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	hydrolases of HD superfamily	MA20_42120	-	-	ko:K06952	-	-	-	-	ko00000	-	-	-	HD,HD_3
TLS2_k127_2045302_14	717785.HYPMC_2111	3.877e-91	307.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria,3N8SM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.1.1.41,4.2.1.17	ko:K01692,ko:K11264	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R00923,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00097,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_2045302_3	1510531.JQJJ01000008_gene3538	3.951e-256	814.0	COG4485@1|root,COG4485@2|Bacteria,1NBM0@1224|Proteobacteria,2U1FH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Bacterial membrane protein, YfhO	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2045302_31	1380355.JNIJ01000004_gene2968	1.695e-14	83.0	2D22U@1|root,32TC0@2|Bacteria,1MWUI@1224|Proteobacteria,2TSQ6@28211|Alphaproteobacteria,3JQRV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
TLS2_k127_2045302_4	1502851.FG93_00242	9.899e-243	762.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JSXK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
TLS2_k127_2045302_12	1336243.JAEA01000003_gene2431	3.332e-109	363.0	COG3181@1|root,COG3181@2|Bacteria,1MW18@1224|Proteobacteria,2TSKY@28211|Alphaproteobacteria,1JRPC@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
TLS2_k127_2045302_1	717785.HYPMC_2197	0.0	1245.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TSUW@28211|Alphaproteobacteria,3N66V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Domain of unknown function (DUF1974)	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
TLS2_k127_2045302_2	1267005.KB911258_gene514	1.233e-303	943.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,3N65P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	MA20_44845	-	1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K01782,ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
TLS2_k127_2045302_33	391615.ABSJ01000002_gene467	5.238e-06	51.0	2DU2E@1|root,33NN7@2|Bacteria,1P5P1@1224|Proteobacteria,1SV3F@1236|Gammaproteobacteria,1JBM0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_204625_0	1267005.KB911259_gene3759	8.454e-104	341.0	COG0616@1|root,COG0616@2|Bacteria,1MY1I@1224|Proteobacteria,2U07G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	OU	Serine dehydrogenase proteinase	-	-	-	-	-	-	-	-	-	-	-	-	SDH_sah
TLS2_k127_204625_2	652103.Rpdx1_4437	4.205e-30	119.0	COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,2UF5Q@28211|Alphaproteobacteria,3K05I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	CsbD-like	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
TLS2_k127_204625_4	1211115.ALIQ01000068_gene3485	1.138e-05	54.0	COG3861@1|root,COG3861@2|Bacteria,1N0R6@1224|Proteobacteria,2TXB2@28211|Alphaproteobacteria,3NBTC@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
TLS2_k127_204625_1	1267005.KB911255_gene2631	2.564e-103	349.0	COG3770@1|root,COG3770@2|Bacteria,1MU9I@1224|Proteobacteria,2TR3K@28211|Alphaproteobacteria,3N7V8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	PFAM peptidase U6 penicillin-insensitive murein endopeptidase	mepA	-	-	ko:K07261	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M74
TLS2_k127_204625_3	1071679.BG57_28455	9.584e-08	54.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VM0U@28216|Betaproteobacteria,1K5R3@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_204625_5	272630.MexAM1_META1p2705	0.0001482	51.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TSQF@28211|Alphaproteobacteria,1JREY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PFAM response regulator receiver	petR	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_2066347_5	1245469.S58_27450	4.608e-174	547.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TTM5@28211|Alphaproteobacteria,3JR50@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate	frc	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS2_k127_2066347_7	331869.BAL199_21029	8.434e-134	436.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2TSWX@28211|Alphaproteobacteria,4BP6B@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TLS2_k127_2066347_1	935548.KI912159_gene2398	2.637e-310	957.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria,43IUB@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
TLS2_k127_2066347_2	1411123.JQNH01000001_gene886	4.124e-276	865.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_2066347_3	1038859.AXAU01000026_gene2330	3.429e-246	773.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria,3JQQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_2066347_6	1038859.AXAU01000026_gene2331	2.574e-153	490.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRS8@28211|Alphaproteobacteria,3JS1M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	nikB	-	-	ko:K02033,ko:K15585	ko02010,ko02024,map02010,map02024	M00239,M00440	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_2066347_8	1038859.AXAU01000026_gene2332	1.075e-124	405.0	COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,2TRX5@28211|Alphaproteobacteria,3JRYA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_2066347_4	631454.N177_2134	8.329e-192	617.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,1JND8@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_2066347_0	1337093.MBE-LCI_1177	0.0	1255.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria,2P7WY@245186|Loktanella	28211|Alphaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS2_k127_2066347_9	1479238.JQMZ01000001_gene1354	3.936e-107	368.0	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2TQVR@28211|Alphaproteobacteria,43XAB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	L	COG0389 Nucleotidyltransferase DNA polymerase involved in DNA repair	imuB	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS,IMS_C
TLS2_k127_2066347_12	402881.Plav_2527	4.581e-22	109.0	COG4544@1|root,COG4544@2|Bacteria,1MY56@1224|Proteobacteria,2TT91@28211|Alphaproteobacteria,1JPC2@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	SOS response	-	-	-	ko:K14160	-	-	-	-	ko00000,ko03400	-	-	-	-
TLS2_k127_2066347_10	1267005.KB911262_gene3317	1.617e-71	255.0	COG1376@1|root,COG1376@2|Bacteria,1NHM3@1224|Proteobacteria,2UHVV@28211|Alphaproteobacteria,3N8IS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS2_k127_2066347_11	1267005.KB911257_gene929	3.069e-52	197.0	COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,2U33F@28211|Alphaproteobacteria,3N73Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1223)	MA20_43790	-	-	-	-	-	-	-	-	-	-	-	DUF1223
TLS2_k127_2068567_0	1267005.KB911258_gene382	0.0	1495.0	COG3391@1|root,COG3391@2|Bacteria,1MXN7@1224|Proteobacteria,2TR83@28211|Alphaproteobacteria,3N66Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	GTA TIM-barrel-like domain	-	-	-	-	-	-	-	-	-	-	-	-	GTA_TIM,Phage-tail_3
TLS2_k127_2068567_2	1267005.KB911258_gene383	1.173e-124	413.0	COG3926@1|root,COG3926@2|Bacteria,1QV3R@1224|Proteobacteria,2UDA8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glycosyl hydrolase 108	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_108,PG_binding_3
TLS2_k127_2068567_1	1267005.KB911264_gene3198	8.748e-164	527.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2TQPS@28211|Alphaproteobacteria,3N68Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
TLS2_k127_2068567_3	717785.HYPMC_4191	5.213e-64	226.0	COG1309@1|root,COG1309@2|Bacteria,1RARJ@1224|Proteobacteria,2UAVR@28211|Alphaproteobacteria,3N992@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
TLS2_k127_2068567_4	670307.HYPDE_38123	1.24e-33	136.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,2U18A@28211|Alphaproteobacteria,3N7I5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
TLS2_k127_2083270_6	1267005.KB911258_gene468	2.201e-104	340.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2TRQH@28211|Alphaproteobacteria,3N643@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
TLS2_k127_2083270_3	1238182.C882_0345	4.754e-172	550.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TSBB@28211|Alphaproteobacteria,2JR85@204441|Rhodospirillales	204441|Rhodospirillales	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.83,1.1.1.93,4.1.1.73	ko:K07246	ko00630,ko00650,map00630,map00650	-	R00215,R01751,R02545,R06180	RC00084,RC00105,RC00594	ko00000,ko00001,ko01000	-	-	-	Iso_dh
TLS2_k127_2083270_2	670307.HYPDE_23578	4.387e-179	565.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2TR5I@28211|Alphaproteobacteria,3N6AZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
TLS2_k127_2083270_1	331869.BAL199_17663	4.314e-182	579.0	COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,2TRTW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_2083270_7	1122132.AQYH01000020_gene37	1.148e-38	153.0	COG0546@1|root,COG0546@2|Bacteria,1QURP@1224|Proteobacteria,2U7IH@28211|Alphaproteobacteria,4BJPS@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS2_k127_2083270_0	1380394.JADL01000004_gene5809	1.417e-207	659.0	COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,2TRJG@28211|Alphaproteobacteria,2JR42@204441|Rhodospirillales	204441|Rhodospirillales	S	SpoVR like protein	-	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
TLS2_k127_2083270_4	1244869.H261_22683	4.424e-139	453.0	COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,2TTWI@28211|Alphaproteobacteria,2JQ0A@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the UPF0229 family	-	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444
TLS2_k127_2083270_5	1030157.AFMP01000014_gene3441	6.649e-124	399.0	COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,2TTW4@28211|Alphaproteobacteria,2K2H9@204457|Sphingomonadales	204457|Sphingomonadales	T	PrkA AAA domain	prkA	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
TLS2_k127_208755_9	1267005.KB911256_gene1507	1.401e-95	323.0	COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,2TSP6@28211|Alphaproteobacteria,3N6ZE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
TLS2_k127_208755_24	765910.MARPU_01770	1.701e-41	162.0	COG1238@1|root,COG1238@2|Bacteria,1RHUV@1224|Proteobacteria,1S69A@1236|Gammaproteobacteria,1WYYQ@135613|Chromatiales	135613|Chromatiales	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_208755_8	1096546.WYO_5825	3.265e-113	379.0	COG0684@1|root,COG0684@2|Bacteria,1MUWV@1224|Proteobacteria,2TU1X@28211|Alphaproteobacteria,1JQS1@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
TLS2_k127_208755_15	742159.HMPREF0004_5030	9.292e-59	208.0	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,2VUC4@28216|Betaproteobacteria,3T7DE@506|Alcaligenaceae	28216|Betaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme family protein 4	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS2_k127_208755_17	1267005.KB911256_gene1777	9.866e-51	183.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2UBSV@28211|Alphaproteobacteria,3N71E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
TLS2_k127_208755_22	670307.HYPDE_23608	1.178e-46	173.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,2U95Q@28211|Alphaproteobacteria,3N73P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
TLS2_k127_208755_13	264198.Reut_A1906	1.308e-70	248.0	COG1024@1|root,COG1024@2|Bacteria,1PK5J@1224|Proteobacteria,2VPWF@28216|Betaproteobacteria,1K270@119060|Burkholderiaceae	28216|Betaproteobacteria	I	enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_208755_26	331869.BAL199_19868	3.61e-28	126.0	COG0346@1|root,COG0346@2|Bacteria,1RFHY@1224|Proteobacteria,2UCMJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
TLS2_k127_208755_12	318996.AXAZ01000042_gene1993	9.386e-76	266.0	COG0491@1|root,COG0491@2|Bacteria,1NK1F@1224|Proteobacteria,2TR5Q@28211|Alphaproteobacteria,3JSQP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	MA20_19225	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_208755_5	1267005.KB911258_gene129	7.403e-172	550.0	COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,2TSKB@28211|Alphaproteobacteria,3N701@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Orn DAP Arg decarboxylase 2	ldc	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS2_k127_208755_7	1297569.MESS2_1190049	7.993e-126	414.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,43H9K@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
TLS2_k127_208755_28	263358.VAB18032_17300	3.471e-26	117.0	COG2453@1|root,COG2453@2|Bacteria,2IK44@201174|Actinobacteria,4DG97@85008|Micromonosporales	201174|Actinobacteria	T	phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	CDKN3,DSPc
TLS2_k127_208755_6	582899.Hden_2018	2.264e-143	463.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2TR9Q@28211|Alphaproteobacteria,3N6J0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	RNA polymerase sigma factor RpoH	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
TLS2_k127_208755_0	1205680.CAKO01000030_gene4966	5.83e-278	864.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,2JRI5@204441|Rhodospirillales	28211|Alphaproteobacteria	P	Flavin-binding monooxygenase-like	-	-	1.14.13.160,1.14.13.22	ko:K03379,ko:K21730	ko00930,ko01120,ko01220,map00930,map01120,map01220	-	R02231,R06622	RC00662,RC01550	ko00000,ko00001,ko01000	-	-	-	FMO-like,Pyr_redox_2,Pyr_redox_3
TLS2_k127_208755_19	1123072.AUDH01000019_gene2222	1.809e-49	186.0	COG0028@1|root,COG0028@2|Bacteria,1R6QP@1224|Proteobacteria,2TXAJ@28211|Alphaproteobacteria,2JWX2@204441|Rhodospirillales	204441|Rhodospirillales	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
TLS2_k127_208755_20	1125973.JNLC01000012_gene941	3.457e-49	181.0	COG4032@1|root,COG4032@2|Bacteria,1P0HU@1224|Proteobacteria,2TRJ2@28211|Alphaproteobacteria,3JQMU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	MA20_16825	-	4.1.1.79	ko:K06034	ko00680,ko01120,map00680,map01120	M00358	R05774	RC00506	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_N
TLS2_k127_208755_2	1121106.JQKB01000027_gene1883	7.861e-196	621.0	COG2141@1|root,COG2141@2|Bacteria,1NKS6@1224|Proteobacteria,2TT87@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_208755_11	1122929.KB908231_gene3579	1.003e-82	285.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2TS81@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Stress-induced protein	yicC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
TLS2_k127_208755_14	1267005.KB911258_gene604	9.312e-70	255.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria,3N6V4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
TLS2_k127_208755_4	631454.N177_3897	1.142e-174	567.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,2TSJC@28211|Alphaproteobacteria,1JQ01@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Proton-conducting membrane transporter	nuoL3	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
TLS2_k127_208755_30	631454.N177_3896	3.906e-07	61.0	2EDYZ@1|root,337TS@2|Bacteria,1N7SA@1224|Proteobacteria,2UNBF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_208755_1	631454.N177_3895	2.768e-196	629.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2U1B0@28211|Alphaproteobacteria,1JPY4@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Proton-conducting membrane transporter	nuoL2	-	1.6.5.3	ko:K00341,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TLS2_k127_208755_3	631454.N177_3894	2.112e-180	582.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,1JP3A@119043|Rhodobiaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	nuoN2	-	1.6.5.3	ko:K00343,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M
TLS2_k127_208755_23	1122132.AQYH01000010_gene3788	6.751e-42	163.0	COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria,2UA1Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG1006 Multisubunit Na H antiporter, MnhC subunit	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
TLS2_k127_208755_18	631454.N177_3892	1.915e-50	184.0	COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,2UCMV@28211|Alphaproteobacteria,1JQAD@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MnhB
TLS2_k127_208755_16	631454.N177_3891	1.163e-56	203.0	COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,2U7UT@28211|Alphaproteobacteria,1JQ4B@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Domain of unknown function (DUF4040)	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040
TLS2_k127_208755_27	631454.N177_3890	8.978e-28	119.0	COG1320@1|root,COG1320@2|Bacteria,1N75I@1224|Proteobacteria,2UETR@28211|Alphaproteobacteria,1JPKS@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
TLS2_k127_208755_29	631454.N177_3889	1.206e-24	106.0	COG2212@1|root,COG2212@2|Bacteria,1N6VV@1224|Proteobacteria,2UHB7@28211|Alphaproteobacteria,1JQJT@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
TLS2_k127_208755_25	631454.N177_3888	1.355e-37	147.0	COG1863@1|root,COG1863@2|Bacteria,1MZYJ@1224|Proteobacteria,2UBYN@28211|Alphaproteobacteria,1JQAQ@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Na+/H+ ion antiporter subunit	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
TLS2_k127_208755_21	1207063.P24_14534	6.222e-47	175.0	2C02K@1|root,32R69@2|Bacteria,1RK2Q@1224|Proteobacteria,2U9PI@28211|Alphaproteobacteria,2JT3N@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_208755_10	1041147.AUFB01000006_gene2236	1.381e-89	299.0	COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2TQYU@28211|Alphaproteobacteria,4BAV7@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	hydrolase	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
TLS2_k127_2088669_4	1205680.CAKO01000038_gene1974	2.178e-27	123.0	2FCNP@1|root,344RX@2|Bacteria,1P1AX@1224|Proteobacteria,2UVS5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_2088669_3	1207063.P24_12312	5.475e-106	347.0	COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,2TS23@28211|Alphaproteobacteria,2JQSY@204441|Rhodospirillales	204441|Rhodospirillales	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K11963	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran
TLS2_k127_2088669_2	1187851.A33M_3891	1.964e-107	361.0	COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,2TQVJ@28211|Alphaproteobacteria,3FDVC@34008|Rhodovulum	28211|Alphaproteobacteria	S	Branched-chain amino acid ATP-binding cassette transporter	urtD	-	-	ko:K11962	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_2088669_1	1510531.JQJJ01000012_gene1415	3.075e-181	575.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2TTN2@28211|Alphaproteobacteria,3JRRF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	urtC	-	-	ko:K11961	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
TLS2_k127_2088669_0	1502851.FG93_01216	1.714e-200	639.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2TRMA@28211|Alphaproteobacteria,3JV23@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	urtB	-	-	ko:K11960	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
TLS2_k127_2093294_5	441620.Mpop_4650	1.108e-12	69.0	COG0848@1|root,COG0848@2|Bacteria,1RDJZ@1224|Proteobacteria,2U77T@28211|Alphaproteobacteria,1JVDF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	U	PFAM Biopolymer transport protein ExbD TolR	exbD	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS2_k127_2093294_0	1267005.KB911258_gene425	0.0	1038.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,3N646@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
TLS2_k127_2093294_4	1267005.KB911263_gene1348	2.857e-23	109.0	COG3908@1|root,COG3908@2|Bacteria,1N7PA@1224|Proteobacteria,2UFTN@28211|Alphaproteobacteria,3N7FG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2093)	MA20_05765	-	-	-	-	-	-	-	-	-	-	-	DUF2093
TLS2_k127_2093294_1	582899.Hden_2870	8.846e-196	627.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria,3N6J8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Tetratricopeptide repeat	MA20_42300	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
TLS2_k127_2093294_2	1267005.KB911255_gene2973	3.352e-70	247.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2TUFV@28211|Alphaproteobacteria,3N6X5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_2093294_3	631454.N177_4023	8.696e-24	111.0	COG4961@1|root,COG4961@2|Bacteria,1MWXU@1224|Proteobacteria,2TRQP@28211|Alphaproteobacteria,1JQ4J@119043|Rhodobiaceae	28211|Alphaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad,VWA
TLS2_k127_2095056_2	1267005.KB911259_gene4016	9.106e-192	613.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2TRYB@28211|Alphaproteobacteria,3N88Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome C oxidase accessory protein CcoG	ccoG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
TLS2_k127_2095056_9	1267005.KB911259_gene4017	1.241e-111	375.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2TQW1@28211|Alphaproteobacteria,3N851@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
TLS2_k127_2095056_24	1122963.AUHB01000002_gene1064	3.815e-06	50.0	COG4736@1|root,COG4736@2|Bacteria,1NGV0@1224|Proteobacteria,2UJBS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	PFAM Cbb3-type cytochrome oxidase component	-	-	-	ko:K00407	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixQ
TLS2_k127_2095056_7	1267005.KB911259_gene4019	8.635e-120	388.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2TRGW@28211|Alphaproteobacteria,3N7X4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	cytochrome C	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
TLS2_k127_2095056_1	717785.HYPMC_1728	2.893e-292	903.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2TR2C@28211|Alphaproteobacteria,3N7QH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	ccoN	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
TLS2_k127_2095056_14	717785.HYPMC_0673	4.035e-54	199.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2U36S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator, Crp Fnr family	fixK	-	-	ko:K01420,ko:K15861	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_2095056_5	1079460.ATTQ01000039_gene6240	2.657e-144	474.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,4B880@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
TLS2_k127_2095056_12	670307.HYPDE_25653	8.756e-89	299.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,3N6V5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Two component transcriptional regulator, winged helix family	ompR	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_2095056_0	670307.HYPDE_25633	4.413e-317	993.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,3N6MD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CJ	CoA binding domain	MA20_38090	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
TLS2_k127_2095056_22	1437824.BN940_16606	3.951e-07	59.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2VJUR@28216|Betaproteobacteria,3T6XG@506|Alcaligenaceae	28216|Betaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
TLS2_k127_2095056_21	1131814.JAFO01000001_gene1001	1.012e-08	63.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2TQJN@28211|Alphaproteobacteria,3EYZW@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
TLS2_k127_2095056_25	1089552.KI911559_gene1798	1.442e-05	49.0	COG5622@1|root,COG5622@2|Bacteria,1N6XP@1224|Proteobacteria,2UFG2@28211|Alphaproteobacteria,2JUNN@204441|Rhodospirillales	204441|Rhodospirillales	N	Protein required for attachment to host cells	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
TLS2_k127_2095056_3	1267005.KB911256_gene1505	6.019e-189	597.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2TW3U@28211|Alphaproteobacteria,3N7QP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_2095056_10	991905.SL003B_1502	1.641e-101	335.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2TS3W@28211|Alphaproteobacteria,4BQ2M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	macB	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran
TLS2_k127_2095056_4	1267005.KB911256_gene1503	5.831e-149	489.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2U139@28211|Alphaproteobacteria,3N7PK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
TLS2_k127_2095056_16	69279.BG36_15225	5.31e-32	128.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2TW6Z@28211|Alphaproteobacteria,43QZ6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	pyridine nucleotide-disulfide oxidoreductase	fccB	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2
TLS2_k127_2095056_23	1479238.JQMZ01000001_gene675	6.023e-07	54.0	28Z2G@1|root,2ZKUZ@2|Bacteria,1P7SE@1224|Proteobacteria,2UXVR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2095056_15	1267005.KB911259_gene3777	8.277e-52	187.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria,3N72F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_2095056_18	1304883.KI912532_gene531	1.34e-13	72.0	296ZZ@1|root,2ZU8H@2|Bacteria,1RED2@1224|Proteobacteria,2VJPT@28216|Betaproteobacteria,2KY8T@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2095056_11	395964.KE386496_gene1436	1.303e-94	323.0	COG1463@1|root,COG3218@1|root,COG1463@2|Bacteria,COG3218@2|Bacteria,1NNAG@1224|Proteobacteria,2TSCH@28211|Alphaproteobacteria,3NAHX@45404|Beijerinckiaceae	28211|Alphaproteobacteria	Q	ABC-type transport auxiliary lipoprotein component	MA20_38065	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_trans_aux,MlaD
TLS2_k127_2095056_8	717785.HYPMC_4495	4.42e-114	376.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,3N6N2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	ATPases associated with a variety of cellular activities	yrbF	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TLS2_k127_2095056_6	1267005.KB911264_gene3101	4.308e-143	464.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria,3N632@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS,STAS_2
TLS2_k127_2095056_13	395963.Bind_2099	1.802e-86	300.0	COG4553@1|root,COG4553@2|Bacteria,1NQW0@1224|Proteobacteria,2UQMX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	PHB de-polymerase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	PHB_depo_C
TLS2_k127_2095056_19	690850.Desaf_1092	5.491e-13	74.0	COG5502@1|root,COG5502@2|Bacteria,1NB8V@1224|Proteobacteria,4339I@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Uncharacterized conserved protein (DUF2267)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2267
TLS2_k127_2095056_17	1267005.KB911260_gene3396	4.184e-25	106.0	COG5502@1|root,COG5502@2|Bacteria,1NB8V@1224|Proteobacteria,2U9GZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized conserved protein (DUF2267)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2267
TLS2_k127_2095056_20	322710.Avin_25770	2.701e-12	67.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S8NE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS2_k127_2104690_2	1267005.KB911255_gene2898	5.934e-187	589.0	COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,2TQJD@28211|Alphaproteobacteria,3N6FD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	binding-protein-dependent transport systems inner membrane component	yejB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944	-	ko:K13894	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
TLS2_k127_2104690_0	1267005.KB911255_gene2897	3.508e-253	794.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,3N7Z7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Extracellular solute-binding protein	yejA	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
TLS2_k127_2104690_1	1267005.KB911255_gene2896	1.098e-228	724.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,3N65H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	MA20_18500	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
TLS2_k127_2104690_3	1411123.JQNH01000001_gene3051	1.032e-47	176.0	COG3474@1|root,COG3474@2|Bacteria,1RIDN@1224|Proteobacteria,2U142@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome	cyc	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
TLS2_k127_2134723_0	1267005.KB911256_gene2041	1.535e-245	764.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,3N6GJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS2_k127_2134723_2	670307.HYPDE_34713	1.689e-16	85.0	2DRMU@1|root,33CBD@2|Bacteria,1NGR1@1224|Proteobacteria,2UJFS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2134723_1	648757.Rvan_2297	1.728e-138	444.0	COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,2TURT@28211|Alphaproteobacteria,3N6NX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
TLS2_k127_2134723_4	1380394.JADL01000021_gene1854	0.0007529	46.0	COG5373@1|root,COG5373@2|Bacteria,1N7JV@1224|Proteobacteria,2TR7A@28211|Alphaproteobacteria,2JTYQ@204441|Rhodospirillales	204441|Rhodospirillales	K	Domain of unknown function (DUF4167)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4167
TLS2_k127_2138361_3	1121106.JQKB01000069_gene1667	1.466e-145	471.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,2JPNR@204441|Rhodospirillales	204441|Rhodospirillales	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
TLS2_k127_2138361_7	316057.RPD_4006	6.931e-80	281.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2TSKH@28211|Alphaproteobacteria,3JST4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_2138361_4	1177181.T9A_03121	4.816e-123	407.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,1RPW2@1236|Gammaproteobacteria,1XNU1@135619|Oceanospirillales	135619|Oceanospirillales	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_2138361_10	324057.Pjdr2_5377	7.159e-65	234.0	COG1028@1|root,COG1028@2|Bacteria,1TSCT@1239|Firmicutes,4HD4Z@91061|Bacilli,26S0W@186822|Paenibacillaceae	91061|Bacilli	IQ	short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_2138361_1	670307.HYPDE_31003	4.049e-187	593.0	COG0304@1|root,COG0304@2|Bacteria,1MV30@1224|Proteobacteria,2TRYK@28211|Alphaproteobacteria,3N7XI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	ko:K14660	-	-	-	-	ko00000,ko01000	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS2_k127_2138361_11	1267005.KB911258_gene519	2.261e-37	143.0	COG0236@1|root,COG0236@2|Bacteria,1NHZ9@1224|Proteobacteria,2UK27@28211|Alphaproteobacteria,3N8Y5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Phosphopantetheine attachment site	nodF	-	-	ko:K02078,ko:K14661	-	-	-	-	ko00000,ko00001,ko01000	-	-	-	PP-binding
TLS2_k127_2138361_0	1267005.KB911258_gene518	3.901e-247	779.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3N6FI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	lcfA	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_2138361_13	216596.RL3605	0.0001963	51.0	COG3103@1|root,COG4991@2|Bacteria,1RA67@1224|Proteobacteria,2U6RB@28211|Alphaproteobacteria,4BDD5@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Bacterial SH3 domain homologues	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
TLS2_k127_2138361_12	717785.HYPMC_3114	9.138e-12	73.0	COG3103@1|root,COG4991@2|Bacteria,1Q1YG@1224|Proteobacteria,2UMEU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
TLS2_k127_2138361_2	1238182.C882_3458	3.241e-170	543.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2JQYB@204441|Rhodospirillales	204441|Rhodospirillales	I	Belongs to the thiolase family	atoB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_2138361_9	1267005.KB911257_gene896	2.133e-68	241.0	COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,2TW0V@28211|Alphaproteobacteria,3N92Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_25205	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	SEC-C,adh_short
TLS2_k127_2138361_8	1120956.JHZK01000008_gene505	7.491e-72	253.0	COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,2TU60@28211|Alphaproteobacteria,1JNM6@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	Glutamine amidotransferase class-I	guaA2	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
TLS2_k127_2138361_6	196490.AUEZ01000055_gene235	2.349e-88	295.0	2AUXR@1|root,2ZBPW@2|Bacteria,1RAID@1224|Proteobacteria,2U6KV@28211|Alphaproteobacteria,3JYM4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2138361_5	1267005.KB911256_gene1756	1.019e-104	347.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2TVXI@28211|Alphaproteobacteria,3N6CV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_2162045_9	631454.N177_1486	2.99e-11	68.0	COG1028@1|root,COG1028@2|Bacteria,1R3U8@1224|Proteobacteria,2U1SI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_2162045_7	1038862.KB893806_gene2978	3.26e-36	156.0	COG0457@1|root,COG0457@2|Bacteria,1RKBA@1224|Proteobacteria,2TRAV@28211|Alphaproteobacteria,3JVYV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
TLS2_k127_2162045_10	272630.MexAM1_META1p1285	1.16e-10	72.0	COG1813@1|root,COG1813@2|Bacteria,1MXA5@1224|Proteobacteria,2TU2N@28211|Alphaproteobacteria,1JR8X@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
TLS2_k127_2162045_2	1267005.KB911260_gene3473	2.091e-83	287.0	2DBB3@1|root,2Z85F@2|Bacteria,1N6NI@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (4846)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4846
TLS2_k127_2162045_4	1038860.AXAP01000012_gene1230	7.51e-57	200.0	COG3795@1|root,COG3795@2|Bacteria,1RJIJ@1224|Proteobacteria,2U967@28211|Alphaproteobacteria,3JYRU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	YCII-related domain	MA20_04110	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_2162045_0	1038859.AXAU01000012_gene4200	9.037e-176	567.0	COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,2TSNH@28211|Alphaproteobacteria,3JT2N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	MA20_04105	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2162045_6	1205680.CAKO01000040_gene748	4.921e-46	184.0	COG2764@1|root,COG2764@2|Bacteria,1RJPS@1224|Proteobacteria,2UACG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_2162045_5	1121015.N789_03795	2.62e-46	169.0	COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,1S6KT@1236|Gammaproteobacteria,1X7NJ@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1428)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1428
TLS2_k127_2162045_3	663610.JQKO01000003_gene1507	7.189e-62	216.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2U993@28211|Alphaproteobacteria,3NBAH@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
TLS2_k127_2162045_8	502025.Hoch_4464	1.651e-27	117.0	COG1977@1|root,COG1977@2|Bacteria,1N4M4@1224|Proteobacteria,43BB7@68525|delta/epsilon subdivisions,2X6QD@28221|Deltaproteobacteria,2Z3C9@29|Myxococcales	28221|Deltaproteobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
TLS2_k127_2162045_1	1121920.AUAU01000004_gene579	3.607e-159	509.0	COG4447@1|root,COG4447@2|Bacteria,3Y3TM@57723|Acidobacteria	57723|Acidobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
TLS2_k127_2162045_11	1187851.A33M_3613	2.635e-08	55.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR15@28211|Alphaproteobacteria,3FDNU@34008|Rhodovulum	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	fadE	-	1.3.8.7,1.3.8.8	ko:K00249,ko:K00255	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_219723_0	670307.HYPDE_33818	6.405e-145	462.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria,3N6JX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS2_k127_219723_7	1282876.BAOK01000001_gene1263	2.827e-68	245.0	COG0697@1|root,COG0697@2|Bacteria,1N024@1224|Proteobacteria,2U4N2@28211|Alphaproteobacteria,4BQFF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EG	PFAM EamA-like transporter family	ydeD	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_219723_4	1038867.AXAY01000006_gene4044	7.425e-94	314.0	COG0625@1|root,COG0625@2|Bacteria,1RC4Y@1224|Proteobacteria,2U6JK@28211|Alphaproteobacteria,3JVU5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
TLS2_k127_219723_5	172088.AUGA01000008_gene1075	6.767e-86	298.0	COG1804@1|root,COG1804@2|Bacteria,1QNB4@1224|Proteobacteria,2TS7Q@28211|Alphaproteobacteria,3JWMB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_219723_8	1429916.X566_04765	1.416e-61	216.0	COG2030@1|root,COG2030@2|Bacteria,1R4VU@1224|Proteobacteria,2U1U9@28211|Alphaproteobacteria,3JT0N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	MaoC like domain	MA20_44010	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS2_k127_219723_1	1267005.KB911259_gene4030	1.356e-138	458.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2TQJN@28211|Alphaproteobacteria,3N89U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Zeta toxin	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
TLS2_k127_219723_10	1122180.Lokhon_01483	5.57e-17	89.0	COG3090@1|root,COG3090@2|Bacteria,1R9XF@1224|Proteobacteria,2U6EU@28211|Alphaproteobacteria,2P93I@245186|Loktanella	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_219723_2	400668.Mmwyl1_0521	1e-127	421.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1XH3S@135619|Oceanospirillales	135619|Oceanospirillales	G	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_219723_6	400668.Mmwyl1_0526	2.539e-68	245.0	COG1638@1|root,COG1638@2|Bacteria,1NJX4@1224|Proteobacteria,1RQF6@1236|Gammaproteobacteria,1XNN0@135619|Oceanospirillales	135619|Oceanospirillales	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_219723_3	331869.BAL199_13528	7.264e-122	397.0	COG2030@1|root,COG2030@2|Bacteria,1MUR2@1224|Proteobacteria,2TUM7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
TLS2_k127_219723_9	85643.Tmz1t_1048	2.966e-34	137.0	2CD5S@1|root,333ZI@2|Bacteria,1N8B8@1224|Proteobacteria	1224|Proteobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
TLS2_k127_2258132_2	266779.Meso_2150	4.589e-93	313.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2TTNS@28211|Alphaproteobacteria,43GWY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
TLS2_k127_2258132_1	1267005.KB911256_gene1490	5.616e-103	347.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2TRHW@28211|Alphaproteobacteria,3N6U6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	MA20_05390	-	2.1.1.79	ko:K00574,ko:K18164	ko04714,map04714	-	-	-	ko00000,ko00001,ko01000,ko03029	-	-	-	Methyltransf_28
TLS2_k127_2258132_4	196490.AUEZ01000075_gene7663	2.216e-14	81.0	COG5436@1|root,COG5436@2|Bacteria,1MW0D@1224|Proteobacteria,2TU65@28211|Alphaproteobacteria,3JSRN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	MA20_15590	-	-	-	-	-	-	-	-	-	-	-	DUF1254
TLS2_k127_2258132_3	1267005.KB911258_gene362	2.485e-52	191.0	COG5402@1|root,COG5402@2|Bacteria,1N26C@1224|Proteobacteria,2TT9K@28211|Alphaproteobacteria,3N79F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1214)	MA20_15585	-	-	-	-	-	-	-	-	-	-	-	DUF1214
TLS2_k127_2258132_0	717785.HYPMC_2405	1.482e-120	399.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,3N61H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	penicillin-binding protein	pbp	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS2_k127_2262095_2	1038858.AXBA01000011_gene1587	1.186e-122	402.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,2TT31@28211|Alphaproteobacteria,3EYS4@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Lysine-2,3-aminomutase	kamA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
TLS2_k127_2262095_1	1449049.JONW01000002_gene2478	9.992e-160	510.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,2TRD4@28211|Alphaproteobacteria,2KG86@204458|Caulobacterales	204458|Caulobacterales	J	class II (D K and N)	-	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
TLS2_k127_2262095_3	717785.HYPMC_1583	2.083e-90	301.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2TUWE@28211|Alphaproteobacteria,3N6MS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TLS2_k127_2262095_0	443598.AUFA01000002_gene2469	1.242e-280	876.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,3JSM0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Alkyl sulfatase dimerisation	MA20_17395	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
TLS2_k127_2308204_3	1207063.P24_07684	6.156e-93	319.0	COG2271@1|root,COG2271@2|Bacteria,1R8Q1@1224|Proteobacteria,2U16E@28211|Alphaproteobacteria,2JRZF@204441|Rhodospirillales	204441|Rhodospirillales	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_2308204_4	1429916.X566_19035	3.314e-92	310.0	COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,2TW0W@28211|Alphaproteobacteria,3K6DW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_2308204_2	1267005.KB911256_gene1820	1.407e-197	621.0	COG0019@1|root,COG0019@2|Bacteria,1MW3T@1224|Proteobacteria,2TVR1@28211|Alphaproteobacteria,3N8DX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily	nspC	-	4.1.1.96	ko:K13747	ko00330,ko01100,map00330,map01100	-	R09081,R09082	RC00299	ko00000,ko00001,ko01000	-	-	-	Orn_DAP_Arg_deC
TLS2_k127_2308204_1	670307.HYPDE_30493	2.452e-203	647.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2TS6F@28211|Alphaproteobacteria,3N6HQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
TLS2_k127_2308204_5	670307.HYPDE_36623	0.0002799	46.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,3N67I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
TLS2_k127_2308204_0	1254432.SCE1572_18575	3.475e-305	969.0	COG2267@1|root,COG2303@1|root,COG2267@2|Bacteria,COG2303@2|Bacteria,1QQ8F@1224|Proteobacteria,42PWF@68525|delta/epsilon subdivisions,2WKVA@28221|Deltaproteobacteria,2YYIQ@29|Myxococcales	28221|Deltaproteobacteria	E	GMC oxidoreductase	choD	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_2320507_9	1187851.A33M_0036	2.203e-50	181.0	COG2185@1|root,COG2185@2|Bacteria,1QU3N@1224|Proteobacteria,2TVY1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
TLS2_k127_2320507_8	1217720.ALOX01000029_gene3802	2.099e-59	210.0	COG2345@1|root,COG2345@2|Bacteria,1RIDX@1224|Proteobacteria,2U9M4@28211|Alphaproteobacteria,2JSVS@204441|Rhodospirillales	204441|Rhodospirillales	K	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
TLS2_k127_2320507_3	670307.HYPDE_27688	5.731e-140	460.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2TTV2@28211|Alphaproteobacteria,3N85Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Peptidase M48 Ste24p	MA20_29180	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_16,TPR_19
TLS2_k127_2320507_5	1267005.KB911255_gene2885	1.856e-81	280.0	COG1651@1|root,COG1651@2|Bacteria,1MY3H@1224|Proteobacteria,2TTXR@28211|Alphaproteobacteria,3N6VS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	DSBA-like thioredoxin domain	MA20_29175	-	-	-	-	-	-	-	-	-	-	-	DSBA,Thioredoxin_4
TLS2_k127_2320507_7	1267005.KB911255_gene2886	1.93e-61	216.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria,3N6YB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
TLS2_k127_2320507_10	1267005.KB911255_gene2887	3.807e-49	184.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2U93Y@28211|Alphaproteobacteria,3N6VQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
TLS2_k127_2320507_1	1267005.KB911255_gene2888	1.144e-257	802.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2U25Z@28211|Alphaproteobacteria,3N6AF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Biotin carboxylase	accC	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TLS2_k127_2320507_11	1500301.JQMF01000041_gene3224	5.066e-43	168.0	COG3210@1|root,COG3210@2|Bacteria,1RBJV@1224|Proteobacteria,2U6VU@28211|Alphaproteobacteria,4BCVQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	Hint domain	-	-	-	-	-	-	-	-	-	-	-	-	Hint_2
TLS2_k127_2320507_0	582899.Hden_2237	0.0	1047.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,3N62A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Carbamoyl-phosphate synthase L chain ATP-binding	pccA	GO:0003674,GO:0003824,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009374,GO:0009987,GO:0016421,GO:0016874,GO:0016885,GO:0017144,GO:0019752,GO:0019842,GO:0019899,GO:0031406,GO:0031974,GO:0032787,GO:0033218,GO:0033293,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070013,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901681	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
TLS2_k127_2320507_4	762376.AXYL_06680	1.104e-96	323.0	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2VHMD@28216|Betaproteobacteria,3T28I@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059,ko:K07535	ko00061,ko00333,ko00362,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,ko01220,map00061,map00333,map00362,map00780,map01040,map01100,map01120,map01130,map01212,map01220	M00083,M00540,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05582,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117,RC00154	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_2320507_2	1120983.KB894575_gene580	2.11e-161	518.0	COG0369@1|root,COG1149@1|root,COG0369@2|Bacteria,COG1149@2|Bacteria,1NCKQ@1224|Proteobacteria,2VF01@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	benzoyl-CoA oxygenase	boxA	-	1.14.13.208	ko:K15511	ko00362,map00362	-	R09555	RC01739	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer4,NAD_binding_1
TLS2_k127_2320507_12	570952.ATVH01000017_gene1771	6.682e-28	116.0	COG0662@1|root,COG0662@2|Bacteria,1N71F@1224|Proteobacteria,2UFSH@28211|Alphaproteobacteria,2JUW5@204441|Rhodospirillales	204441|Rhodospirillales	G	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2320507_13	243090.RB9418	1.49e-20	95.0	COG3614@1|root,COG4251@1|root,COG3614@2|Bacteria,COG4251@2|Bacteria,2IZ70@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
TLS2_k127_2320507_6	1267005.KB911263_gene1392	3.836e-77	268.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2TRYX@28211|Alphaproteobacteria,3N6XH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	membrane transporter protein	MA20_43555	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_233726_10	765914.ThisiDRAFT_0763	1.192e-14	74.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS2_k127_233726_3	582899.Hden_1956	1.414e-126	411.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,3N6J9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS2_k127_233726_0	1267005.KB911260_gene3553	8.099e-251	778.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria,3N66W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
TLS2_k127_233726_4	1267005.KB911260_gene3552	1.291e-112	367.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2TR5M@28211|Alphaproteobacteria,3N6HZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TLS2_k127_233726_1	1267005.KB911260_gene3551	1.817e-162	524.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2TS8W@28211|Alphaproteobacteria,3N67G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
TLS2_k127_233726_11	1120963.KB894491_gene1107	4.138e-07	61.0	2DE24@1|root,2ZK69@2|Bacteria,1P9N5@1224|Proteobacteria,1SU0Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_233726_6	1267005.KB911263_gene1383	1.805e-75	256.0	COG1522@1|root,COG1522@2|Bacteria,1RDB3@1224|Proteobacteria,2U580@28211|Alphaproteobacteria,3N6RN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K05800	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS2_k127_233726_9	1035191.HMPREF0185_01071	2.009e-21	101.0	COG3453@1|root,COG3453@2|Bacteria,1N9AF@1224|Proteobacteria,2UD2M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF442
TLS2_k127_233726_5	420324.KI912031_gene2679	1.301e-107	352.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,1JRXE@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS2_k127_233726_2	1207063.P24_01300	4.729e-152	487.0	COG0329@1|root,COG0329@2|Bacteria,1MWAH@1224|Proteobacteria,2TSXX@28211|Alphaproteobacteria,2JS0U@204441|Rhodospirillales	204441|Rhodospirillales	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_233726_8	1502851.FG93_03252	4.642e-23	102.0	COG1999@1|root,COG2010@1|root,COG1999@2|Bacteria,COG2010@2|Bacteria,1MYNE@1224|Proteobacteria,2V9Z1@28211|Alphaproteobacteria,3K5DU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
TLS2_k127_2357456_6	1205680.CAKO01000037_gene1218	2.244e-70	240.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,2JUZ6@204441|Rhodospirillales	204441|Rhodospirillales	V	Beta-lactamase	-	-	-	ko:K18372	ko00640,map00640	-	R10705	RC00460,RC00461	ko00000,ko00001,ko01000	-	-	-	Beta-lactamase
TLS2_k127_2357456_5	1380394.JADL01000001_gene2614	3.2e-94	331.0	COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2U0CV@28211|Alphaproteobacteria,2JW09@204441|Rhodospirillales	204441|Rhodospirillales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.14.13.235	ko:K22027	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
TLS2_k127_2357456_2	1230476.C207_04884	4.066e-142	462.0	COG0006@1|root,COG0006@2|Bacteria,1MVJK@1224|Proteobacteria,2TVVP@28211|Alphaproteobacteria,3JSAA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
TLS2_k127_2357456_0	1197906.CAJQ02000004_gene3003	1.319e-268	842.0	COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
TLS2_k127_2357456_3	1156919.QWC_02763	9.125e-132	426.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2VJM3@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase	ubiE_1	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_2357456_7	1205680.CAKO01000002_gene2505	7.377e-67	231.0	COG1917@1|root,COG1917@2|Bacteria,1MZF9@1224|Proteobacteria,2U63E@28211|Alphaproteobacteria,2JXBK@204441|Rhodospirillales	204441|Rhodospirillales	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2357456_1	113395.AXAI01000002_gene5540	1.656e-175	555.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria,3JQMM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_2357456_4	883078.HMPREF9695_03026	1.276e-94	320.0	COG2267@1|root,COG2267@2|Bacteria,1R72P@1224|Proteobacteria,2U2XP@28211|Alphaproteobacteria,3K6SR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_2362476_9	1267005.KB911258_gene91	1.135e-42	158.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria,3N6H0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluC	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_2362476_2	1187851.A33M_2075	4.919e-136	444.0	COG1804@1|root,COG1804@2|Bacteria,1MU4A@1224|Proteobacteria,2TRSB@28211|Alphaproteobacteria,3FDJQ@34008|Rhodovulum	28211|Alphaproteobacteria	C	CoA-transferase family III	MA20_04515	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS2_k127_2362476_8	1121033.AUCF01000003_gene3142	1.066e-66	239.0	COG4395@1|root,COG4395@2|Bacteria,1NSUG@1224|Proteobacteria,2U0SF@28211|Alphaproteobacteria,2JT0W@204441|Rhodospirillales	204441|Rhodospirillales	S	Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
TLS2_k127_2362476_0	1205680.CAKO01000008_gene4166	4.591e-165	533.0	COG0183@1|root,COG0183@2|Bacteria,1MVPC@1224|Proteobacteria,2VEVD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	-
TLS2_k127_2362476_6	1054213.HMPREF9946_01610	4.299e-91	304.0	COG2057@1|root,COG2057@2|Bacteria,1MWW1@1224|Proteobacteria,2VGKV@28211|Alphaproteobacteria,2JRXZ@204441|Rhodospirillales	204441|Rhodospirillales	I	Coenzyme A transferase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_trans
TLS2_k127_2362476_5	631454.N177_3423	9.285e-92	321.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2TTE6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	-	-	2.8.3.6	ko:K01031	ko00362,ko01100,ko01120,map00362,map01100,map01120	-	R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS2_k127_2362476_4	1267005.KB911259_gene3713	1.638e-94	321.0	COG1489@1|root,COG1489@2|Bacteria,1MUC3@1224|Proteobacteria,2U10V@28211|Alphaproteobacteria,3N8EN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the SfsA family	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
TLS2_k127_2362476_1	1408224.SAMCCGM7_c5232	2.6e-138	445.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,4B96F@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Dehydrogenase	MA20_25935	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_2362476_11	1123360.thalar_00558	9.731e-26	119.0	COG2009@1|root,COG2009@2|Bacteria,1N8VA@1224|Proteobacteria,2UAYI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	succinate dehydrogenase	-	-	-	ko:K00247	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS2_k127_2362476_10	266809.PM03_08165	9.38e-29	121.0	COG2142@1|root,COG2142@2|Bacteria,1MZKE@1224|Proteobacteria,2UDDU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	succinate dehydrogenase	-	-	-	ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS2_k127_2362476_3	331869.BAL199_12976	2.204e-102	345.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2U08R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Succinate dehydrogenase Fumarate reductase	frdB	-	1.3.5.4	ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_17,Fer4_8
TLS2_k127_2362476_7	488538.SAR116_0316	3.579e-75	256.0	COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,2TRK0@28211|Alphaproteobacteria,4BQYJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Mo-co oxidoreductase dimerisation domain	-	-	-	ko:K17225	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Mo-co_dimer,Oxidored_molyb
TLS2_k127_2409155_3	717785.HYPMC_0750	3.857e-85	291.0	COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,2TQTX@28211|Alphaproteobacteria,3N6SG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	inositol mono-phosphatase	hisN	-	3.1.3.15,3.1.3.25,3.1.3.93	ko:K01092,ko:K18649	ko00053,ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00053,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00114,M00131	R01185,R01186,R01187,R03013,R07674	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS2_k127_2409155_1	1267005.KB911259_gene3864	1.063e-163	546.0	COG1842@1|root,COG1842@2|Bacteria,1QW5I@1224|Proteobacteria,2TWNE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	N-terminal domain of unknown function (DUF4140)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
TLS2_k127_2409155_2	1123072.AUDH01000005_gene1729	1.793e-94	316.0	COG1028@1|root,COG1028@2|Bacteria,1NBB6@1224|Proteobacteria,2TVF5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_2409155_0	670307.HYPDE_23828	8.447e-248	775.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,3N6JN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	UvrD-like helicase C-terminal domain	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS2_k127_2437049_25	748247.AZKH_3413	2.549e-13	72.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VK75@28216|Betaproteobacteria	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	paaH	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_2437049_24	1166018.FAES_1243	3.661e-23	114.0	COG0501@1|root,COG4642@1|root,COG0501@2|Bacteria,COG4642@2|Bacteria,4NJPY@976|Bacteroidetes,47K9K@768503|Cytophagia	976|Bacteroidetes	O	Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases.	-	-	-	-	-	-	-	-	-	-	-	-	MORN,Peptidase_C14,Peptidase_M48
TLS2_k127_2437049_14	1469245.JFBG01000010_gene606	2.365e-52	192.0	COG0662@1|root,COG0662@2|Bacteria,1NX8W@1224|Proteobacteria	1224|Proteobacteria	G	PFAM Cupin 2 conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2437049_1	331869.BAL199_12991	1.533e-271	845.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria,4BPP2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_2437049_0	717785.HYPMC_3913	0.0	1452.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,3N65N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
TLS2_k127_2437049_13	1267005.KB911258_gene497	4.334e-63	223.0	COG3545@1|root,COG3545@2|Bacteria,1RDB7@1224|Proteobacteria,2U607@28211|Alphaproteobacteria,3N70P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Serine hydrolase	-	-	-	ko:K07002	-	-	-	-	ko00000	-	-	-	Ser_hydrolase
TLS2_k127_2437049_3	107635.AZUO01000001_gene861	3.619e-192	605.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2TQY2@28211|Alphaproteobacteria,36X7K@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Chorismate synthase	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
TLS2_k127_2437049_12	1267005.KB911257_gene1027	6.908e-67	233.0	COG0454@1|root,COG0456@2|Bacteria,1N6RY@1224|Proteobacteria,2TSVU@28211|Alphaproteobacteria,3N944@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	GCN5-related N-acetyltransferase	MA20_25245	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_2437049_5	1205680.CAKO01000027_gene4746	1.309e-165	535.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2TR37@28211|Alphaproteobacteria,2JV8F@204441|Rhodospirillales	204441|Rhodospirillales	C	Malate/L-lactate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
TLS2_k127_2437049_16	335659.S23_03190	1.084e-40	161.0	COG2242@1|root,COG2242@2|Bacteria,1QVKC@1224|Proteobacteria,2TWH7@28211|Alphaproteobacteria,3JSSP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Vibrio cholerae RfbT protein	MA20_43520	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
TLS2_k127_2437049_10	1429916.X566_08060	1.868e-94	314.0	COG0684@1|root,COG0684@2|Bacteria,1MUES@1224|Proteobacteria,2U0IC@28211|Alphaproteobacteria,3JTIV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Aldolase/RraA	MA20_26380	-	-	-	-	-	-	-	-	-	-	-	RraA-like
TLS2_k127_2437049_11	331869.BAL199_17828	1.332e-73	262.0	COG3206@1|root,COG3206@2|Bacteria,1RDNS@1224|Proteobacteria,2U7JM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Uncharacterized protein conserved in bacteria (DUF2325)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2325
TLS2_k127_2437049_23	1267005.KB911256_gene1753	6.118e-27	112.0	2EP0Y@1|root,33GMT@2|Bacteria,1Q7FE@1224|Proteobacteria,2VDKN@28211|Alphaproteobacteria,3N7CM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	BFD-like [2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD
TLS2_k127_2437049_18	1267005.KB911256_gene1752	4.231e-38	149.0	2D9BM@1|root,32TSZ@2|Bacteria,1RJ7Z@1224|Proteobacteria,2UAMP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2437049_7	1267005.KB911257_gene844	1.804e-126	413.0	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,2TR6P@28211|Alphaproteobacteria,3N7BW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	futA1	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
TLS2_k127_2437049_19	717785.HYPMC_0595	3.229e-32	132.0	COG1959@1|root,COG1959@2|Bacteria,1N05H@1224|Proteobacteria,2UAFS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	rirA	-	-	ko:K13771,ko:K13772	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	Rrf2
TLS2_k127_2437049_26	414684.RC1_3857	2.485e-07	59.0	COG4256@1|root,COG4256@2|Bacteria,1NGJH@1224|Proteobacteria	1224|Proteobacteria	P	Hemin uptake protein	hmuP	-	-	-	-	-	-	-	-	-	-	-	hemP
TLS2_k127_2437049_17	1336245.JAGO01000013_gene1645	1.334e-40	156.0	COG2329@1|root,COG2329@2|Bacteria,1MZKW@1224|Proteobacteria,1S9N8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS2_k127_2437049_9	1267005.KB911257_gene736	3.505e-98	333.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2TTT4@28211|Alphaproteobacteria,3N6BM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS2_k127_2437049_21	582899.Hden_3349	2.503e-30	126.0	2BXM2@1|root,3159P@2|Bacteria,1PVB8@1224|Proteobacteria,2V74V@28211|Alphaproteobacteria,3N905@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2628)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2628
TLS2_k127_2437049_8	582899.Hden_3348	2.296e-104	344.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2TTVV@28211|Alphaproteobacteria,3N6PK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.9,3.1.3.15,4.2.1.19	ko:K00817,ko:K01089,ko:K01693	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03013,R03243,R03457	RC00006,RC00017,RC00888,RC00932	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	IGPD
TLS2_k127_2437049_4	1267005.KB911255_gene2458	1.164e-181	608.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	-
TLS2_k127_2437049_6	1267005.KB911255_gene2457	1.006e-132	434.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,3N6HK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	MA20_18575	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_2437049_15	1354722.JQLS01000001_gene4700	1.893e-48	179.0	COG0599@1|root,COG0599@2|Bacteria,1RJU6@1224|Proteobacteria,2U5JQ@28211|Alphaproteobacteria,46QUA@74030|Roseovarius	28211|Alphaproteobacteria	S	gamma-carboxymuconolactone decarboxylase subunit	MA20_20490	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
TLS2_k127_2437049_20	717785.HYPMC_1137	1.717e-30	130.0	COG1605@1|root,COG1605@2|Bacteria,1PV10@1224|Proteobacteria,2V6I1@28211|Alphaproteobacteria,3N78S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Chorismate mutase, type II	-	-	4.2.99.21	ko:K04782	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R06602	RC01549,RC02148	ko00000,ko00001,ko01000	-	-	-	CM_2
TLS2_k127_2437049_27	441620.Mpop_3524	4.446e-05	49.0	2DQTS@1|root,338MI@2|Bacteria,1NE6H@1224|Proteobacteria,2UG0C@28211|Alphaproteobacteria,1JVUH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2437049_2	1206737.BAGF01000151_gene6229	4.715e-193	612.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FTYX@85025|Nocardiaceae	201174|Actinobacteria	IQ	Acyl-CoA synthetase	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_2441781_0	1469245.JFBG01000049_gene2176	8.729e-265	836.0	COG1520@1|root,COG1520@2|Bacteria,1QXZ5@1224|Proteobacteria,1SZJA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2441781_1	331869.BAL199_24709	2.051e-128	420.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria,4BPUP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_2459308_6	1380350.JIAP01000006_gene2716	1.016e-100	336.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,43J03@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Ammonium Transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TLS2_k127_2459308_7	717785.HYPMC_4614	1.706e-54	194.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U952@28211|Alphaproteobacteria,3N8IE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Belongs to the P(II) protein family	glnK	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
TLS2_k127_2459308_3	1122929.KB908218_gene1605	3.303e-126	411.0	COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,2TRFD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA thioesterase	tesB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
TLS2_k127_2459308_2	1267005.KB911257_gene1043	2.914e-134	439.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TRZU@28211|Alphaproteobacteria,3N6KV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	ubiH	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
TLS2_k127_2459308_8	1121451.DESAM_20456	0.0001757	52.0	COG2242@1|root,COG3774@1|root,COG2242@2|Bacteria,COG3774@2|Bacteria,1R2IC@1224|Proteobacteria,43DF0@68525|delta/epsilon subdivisions,2X8M0@28221|Deltaproteobacteria,2MAJF@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
TLS2_k127_2459308_5	1207063.P24_08704	5.913e-111	378.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2TS48@28211|Alphaproteobacteria,2JZJU@204441|Rhodospirillales	204441|Rhodospirillales	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_2459308_4	1267005.KB911258_gene403	8.668e-124	405.0	COG0500@1|root,COG0640@1|root,COG0500@2|Bacteria,COG0640@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,3N6M0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	arsR	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Methyltransf_11,Methyltransf_31
TLS2_k127_2459308_1	1267005.KB911258_gene404	4.622e-152	488.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,3N65Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Methylenetetrahydrofolate reductase	metF	GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS2_k127_2459308_0	1267005.KB911258_gene405	1.371e-184	582.0	COG0646@1|root,COG0646@2|Bacteria,1NPFY@1224|Proteobacteria,2UJRS@28211|Alphaproteobacteria,3N8A1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Homocysteine S-methyltransferase	metH	-	2.1.1.13,2.1.1.5	ko:K00544,ko:K00548	ko00260,ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00260,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R02821,R09365	RC00035,RC00113,RC00496,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
TLS2_k127_2491326_16	322710.Avin_43990	1.245e-58	219.0	COG0471@1|root,COG0471@2|Bacteria,1N58G@1224|Proteobacteria,1RN9C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_sulph_symp
TLS2_k127_2491326_9	187303.BN69_3443	3.28e-95	323.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2TUF3@28211|Alphaproteobacteria,36Y7T@31993|Methylocystaceae	28211|Alphaproteobacteria	O	XdhC Rossmann domain	MA20_09415	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS2_k127_2491326_10	351016.RAZWK3B_11026	5.943e-81	280.0	COG1414@1|root,COG1414@2|Bacteria,1R5ZB@1224|Proteobacteria,2TUN3@28211|Alphaproteobacteria,2P1RY@2433|Roseobacter	28211|Alphaproteobacteria	K	COG1414 Transcriptional regulator	-	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
TLS2_k127_2491326_17	1120792.JAFV01000001_gene370	1.994e-52	190.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2UCKH@28211|Alphaproteobacteria,36YRP@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Phosphoribosyl-AMP cyclohydrolase	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
TLS2_k127_2491326_11	631454.N177_4161	8.183e-80	271.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2TSZI@28211|Alphaproteobacteria,1JNRJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
TLS2_k127_2491326_18	1267005.KB911258_gene421	4.599e-50	183.0	COG0822@1|root,COG0822@2|Bacteria,1RDGB@1224|Proteobacteria,2U74A@28211|Alphaproteobacteria,3N6YM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	COG0822 NifU homolog involved in Fe-S cluster formation	nifU	-	-	-	-	-	-	-	-	-	-	-	NifU_N
TLS2_k127_2491326_19	1337936.IJ00_27205	3.604e-47	173.0	COG3837@1|root,COG3837@2|Bacteria,1G5P0@1117|Cyanobacteria,1HNC7@1161|Nostocales	1117|Cyanobacteria	S	PFAM Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2491326_22	1267005.KB911258_gene422	8.353e-40	150.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,2UFKH@28211|Alphaproteobacteria,3N786@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
TLS2_k127_2491326_27	1038860.AXAP01000119_gene806	4.337e-13	81.0	COG0790@1|root,COG0790@2|Bacteria,1R5MB@1224|Proteobacteria,2TV77@28211|Alphaproteobacteria,3JXDS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	COG0790 FOG TPR repeat, SEL1 subfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2491326_8	196490.AUEZ01000025_gene2263	3.396e-107	360.0	COG2358@1|root,COG2358@2|Bacteria,1MWSG@1224|Proteobacteria,2TSVY@28211|Alphaproteobacteria,3JVB2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
TLS2_k127_2491326_20	1197906.CAJQ02000044_gene1623	8.149e-44	168.0	COG1416@1|root,COG1416@2|Bacteria,1RE8C@1224|Proteobacteria,2U7AD@28211|Alphaproteobacteria,3JYQU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	DsrE/DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
TLS2_k127_2491326_26	1267005.KB911256_gene1899	1.37e-23	104.0	COG4321@1|root,COG4321@2|Bacteria,1N7Z2@1224|Proteobacteria,2UF7W@28211|Alphaproteobacteria,3N7DG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Ribbon-helix-helix domain	MA20_02235	-	-	-	-	-	-	-	-	-	-	-	RHH_4
TLS2_k127_2491326_29	1122132.AQYH01000008_gene2327	8.114e-09	61.0	2EFUM@1|root,339KS@2|Bacteria,1NGG6@1224|Proteobacteria,2UJA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4169)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4169
TLS2_k127_2491326_23	631454.N177_1291	2.247e-38	150.0	2CCMQ@1|root,32RW3@2|Bacteria,1MZHB@1224|Proteobacteria,2UCC9@28211|Alphaproteobacteria,1JP72@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2794)	MA20_43795	-	-	-	-	-	-	-	-	-	-	-	DUF2794
TLS2_k127_2491326_12	1267005.KB911255_gene2443	6.813e-69	243.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2TQWQ@28211|Alphaproteobacteria,3N8EU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	synthesis repressor PhaR	phaR	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
TLS2_k127_2491326_3	1168059.KB899087_gene179	5.515e-199	626.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,3EYXU@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	Thiolase, C-terminal domain	phbA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_2491326_7	1267005.KB911255_gene2441	2.451e-113	370.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2TRCF@28211|Alphaproteobacteria,3N82B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	KR domain	phbB	-	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
TLS2_k127_2491326_28	502025.Hoch_4645	2.481e-09	65.0	COG0784@1|root,COG2197@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2197@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42Q3F@68525|delta/epsilon subdivisions,2WM2F@28221|Deltaproteobacteria,2YUEQ@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_8,PAS_9,Response_reg
TLS2_k127_2491326_6	1211115.ALIQ01000225_gene1821	1.174e-159	515.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2TQN5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	COG1541 Coenzyme F390 synthetase	MA20_42595	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
TLS2_k127_2491326_1	1510531.JQJJ01000014_gene4737	9.625e-254	790.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2TTDT@28211|Alphaproteobacteria,3JT6J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	-	-	4.2.1.7	ko:K01685	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
TLS2_k127_2491326_5	1207063.P24_09951	1.824e-160	522.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2TR5D@28211|Alphaproteobacteria,2JPR6@204441|Rhodospirillales	204441|Rhodospirillales	H	Probable molybdopterin binding domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TLS2_k127_2491326_4	1298867.AUES01000041_gene919	7.701e-161	535.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria,3JQWZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
TLS2_k127_2491326_0	744980.TRICHSKD4_2935	1.4e-291	908.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2TS6C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_2491326_24	1123508.JH636441_gene3427	1.541e-30	125.0	2E3V1@1|root,32YSA@2|Bacteria,2J1BP@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2491326_25	1510531.JQJJ01000008_gene3746	2.728e-25	108.0	COG5453@1|root,COG5453@2|Bacteria,1N7WA@1224|Proteobacteria,2UFN1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Transcriptional activator HlyU	hlyU	-	-	-	-	-	-	-	-	-	-	-	HlyU
TLS2_k127_2491326_15	717785.HYPMC_2610	1.186e-61	220.0	COG0861@1|root,COG0861@2|Bacteria,1PN8B@1224|Proteobacteria,2TUV5@28211|Alphaproteobacteria,3N8S2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Integral membrane protein TerC family	terC	-	-	-	-	-	-	-	-	-	-	-	TerC
TLS2_k127_2491326_13	1500259.JQLD01000009_gene1936	2.068e-68	235.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,2U945@28211|Alphaproteobacteria,4BDY9@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TLS2_k127_2491326_14	1267005.KB911259_gene3706	5.514e-64	222.0	COG3761@1|root,COG3761@2|Bacteria,1RHS3@1224|Proteobacteria,2U95G@28211|Alphaproteobacteria,3N71J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NADH ubiquinone oxidoreductase 17.2 kD subunit	MA20_29090	-	1.6.99.3	ko:K00356	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	NDUFA12
TLS2_k127_2491326_21	1267005.KB911259_gene3705	7.963e-43	167.0	COG4765@1|root,COG4765@2|Bacteria,1RHI7@1224|Proteobacteria,2UBR9@28211|Alphaproteobacteria,3N75F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2155)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2155
TLS2_k127_2491326_2	1121106.JQKB01000069_gene1667	3.674e-210	661.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,2JPNR@204441|Rhodospirillales	204441|Rhodospirillales	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
TLS2_k127_2545888_1	1411123.JQNH01000001_gene2590	3.916e-173	551.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	amidohydrolase	MA20_09240	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_2545888_2	1267005.KB911263_gene1288	1.358e-115	379.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2TR7R@28211|Alphaproteobacteria,3N82F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	EH	Amino-transferase class IV	dat	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
TLS2_k127_2545888_0	631454.N177_0180	5.697e-182	581.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2TRP9@28211|Alphaproteobacteria,1JN1G@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS2_k127_2545888_4	1267005.KB911255_gene2583	5.756e-59	213.0	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2TVJ7@28211|Alphaproteobacteria,3N70M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	endonuclease III	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TLS2_k127_2545888_3	1120956.JHZK01000005_gene2243	6.543e-83	284.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1MY9R@1224|Proteobacteria,2TTFW@28211|Alphaproteobacteria,1JPNR@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Peptidase family M50	-	-	-	ko:K06402	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CBS,Peptidase_M50
TLS2_k127_26045_10	717785.HYPMC_0570	4.83e-69	240.0	COG0461@1|root,COG0461@2|Bacteria,1MVP7@1224|Proteobacteria,2TTSB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
TLS2_k127_26045_11	717785.HYPMC_0572	4.288e-63	235.0	COG0526@1|root,COG0526@2|Bacteria,1RDJB@1224|Proteobacteria,2U6H8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_26045_12	392499.Swit_1601	2.21e-57	205.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2U5GR@28211|Alphaproteobacteria,2K5GZ@204457|Sphingomonadales	204457|Sphingomonadales	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
TLS2_k127_26045_8	1267005.KB911256_gene1462	8.265e-80	275.0	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,2TTN5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Ribonuclease, BN	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_26045_13	1267005.KB911258_gene546	2.81e-53	190.0	COG0073@1|root,COG0073@2|Bacteria,1RGU7@1224|Proteobacteria,2U9AH@28211|Alphaproteobacteria,3N76A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Putative tRNA binding domain	csaA	GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0017101,GO:0017102,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K06878	-	-	-	-	ko00000	-	-	-	tRNA_bind
TLS2_k127_26045_2	1267005.KB911256_gene1496	3.195e-201	637.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TQRE@28211|Alphaproteobacteria,3N804@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Signal transduction histidine kinase	envZ	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_26045_5	670307.HYPDE_36098	1.875e-103	349.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TSQF@28211|Alphaproteobacteria,3N7ZT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Two component transcriptional regulator	petR	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_26045_14	631454.N177_3274	8.659e-44	168.0	COG1846@1|root,COG1846@2|Bacteria,1RIX7@1224|Proteobacteria,2U94M@28211|Alphaproteobacteria,1JP2R@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	petP	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS2_k127_26045_4	1411123.JQNH01000001_gene2217	9.396e-132	427.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TR1H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS2_k127_26045_7	1207063.P24_04734	1.08e-94	319.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TRA8@28211|Alphaproteobacteria,2JQRH@204441|Rhodospirillales	204441|Rhodospirillales	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_26045_0	438753.AZC_2938	0.0	1146.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3F0QB@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_26045_9	1411123.JQNH01000001_gene997	3.611e-73	252.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U5BM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs	MA20_09390	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_26045_6	1089551.KE386572_gene1716	9.378e-103	344.0	COG0491@1|root,COG0491@2|Bacteria,1MY6G@1224|Proteobacteria,2TTBX@28211|Alphaproteobacteria,4BRAU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_26045_3	1509405.GV67_12270	4.038e-160	516.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TUMK@28211|Alphaproteobacteria,4B9FV@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS2_k127_26045_1	648757.Rvan_2630	1.888e-220	704.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TSR1@28211|Alphaproteobacteria,3N82N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Involved in Beta-(1-- 2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP- binding domain (NBD) is responsible for energy generation	ndvA	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_261166_6	648757.Rvan_1908	2.939e-05	48.0	COG3415@1|root,COG3415@2|Bacteria,1QWK4@1224|Proteobacteria,2TX0C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_32
TLS2_k127_261166_3	335543.Sfum_3755	4.156e-12	70.0	COG5421@1|root,COG5421@2|Bacteria,1Q09R@1224|Proteobacteria,437PJ@68525|delta/epsilon subdivisions,2WYMZ@28221|Deltaproteobacteria,2MRCG@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_261166_5	903818.KI912269_gene282	6.353e-10	68.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TLS2_k127_261166_4	1121405.dsmv_3780	5.904e-11	68.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales	68525|delta/epsilon subdivisions	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TLS2_k127_261166_1	335543.Sfum_3755	1.835e-39	158.0	COG5421@1|root,COG5421@2|Bacteria,1Q09R@1224|Proteobacteria,437PJ@68525|delta/epsilon subdivisions,2WYMZ@28221|Deltaproteobacteria,2MRCG@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_261166_2	349163.Acry_0284	2.156e-30	126.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TLS2_k127_261166_0	224911.27349114	1.698e-50	183.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2TUMR@28211|Alphaproteobacteria,3JXMT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
TLS2_k127_26226_10	666684.AfiDRAFT_1491	2.032e-31	125.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,3JRJ9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Tetratricopeptide repeat	trxA2	-	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
TLS2_k127_26226_8	1187851.A33M_0009	6.991e-57	208.0	COG3760@1|root,COG3760@2|Bacteria,1RDIG@1224|Proteobacteria,2U87T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	YbaK prolyl-tRNA synthetase	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
TLS2_k127_26226_14	935836.JAEL01000201_gene4586	2.557e-06	51.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_26226_7	864069.MicloDRAFT_00042980	3.396e-65	226.0	COG2510@1|root,COG2510@2|Bacteria,1RJ4E@1224|Proteobacteria,2U7CK@28211|Alphaproteobacteria,1JUXM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	EamA-like transporter family	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
TLS2_k127_26226_0	1122132.AQYH01000019_gene320	5.935e-225	709.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2TRI7@28211|Alphaproteobacteria,4B9RU@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Circularly permuted ATP-grasp type 2	MA20_32420	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
TLS2_k127_26226_3	1125973.JNLC01000018_gene2183	7.717e-122	404.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2TQUM@28211|Alphaproteobacteria,3JRZN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	A predicted alpha-helical domain with a conserved ER motif.	MA20_32425	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
TLS2_k127_26226_6	1298867.AUES01000018_gene4217	2.881e-87	299.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2TTZY@28211|Alphaproteobacteria,3JS6U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial transglutaminase-like N-terminal region	MA20_32430	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
TLS2_k127_26226_5	266835.14026009	3.782e-99	334.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,43KRX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
TLS2_k127_26226_11	717785.HYPMC_1122	1.353e-24	104.0	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,2UF4D@28211|Alphaproteobacteria,3N79H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
TLS2_k127_26226_12	1123054.KB907701_gene1711	1.132e-23	113.0	COG0697@1|root,COG0697@2|Bacteria,1PHRI@1224|Proteobacteria,1RSFS@1236|Gammaproteobacteria,1X14R@135613|Chromatiales	135613|Chromatiales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_26226_2	1267005.KB911255_gene2683	4.287e-147	486.0	COG0389@1|root,COG0389@2|Bacteria,1NTDH@1224|Proteobacteria,2UNYG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332,Zn_dep_PLPC
TLS2_k127_26226_1	582899.Hden_2632	6.646e-163	522.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2TSZN@28211|Alphaproteobacteria,3N61J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntAA	GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TLS2_k127_26226_9	582899.Hden_2631	4.763e-41	158.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,2UBXS@28211|Alphaproteobacteria,3N764@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	pntAB	GO:0008150,GO:0008152,GO:0055114	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
TLS2_k127_26226_4	717785.HYPMC_0774	1.517e-117	384.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2TQN1@28211|Alphaproteobacteria,3N6HG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	GO:0008150,GO:0008152,GO:0055114	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
TLS2_k127_2695609_1	236097.ADG881_223	3.768e-156	507.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1XI7A@135619|Oceanospirillales	135619|Oceanospirillales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_2695609_0	1267005.KB911266_gene1250	1.876e-172	551.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,3N7U4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
TLS2_k127_2695609_2	391616.OA238_c17540	4.309e-121	398.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2UDDB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
TLS2_k127_2807692_10	338969.Rfer_0212	1.674e-69	245.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VK9Y@28216|Betaproteobacteria,4AA2K@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_2807692_9	365046.Rta_22360	2.187e-93	318.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VK6C@28216|Betaproteobacteria,4AB0U@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_2807692_0	1267005.KB911257_gene910	0.0	1140.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,3N61V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_2807692_5	1217720.ALOX01000032_gene184	1.265e-131	427.0	COG4177@1|root,COG4177@2|Bacteria,1MWP3@1224|Proteobacteria,2TR99@28211|Alphaproteobacteria,2JPQ6@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_2807692_4	935261.JAGL01000001_gene1774	1.772e-146	468.0	COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2TSIQ@28211|Alphaproteobacteria,43HTT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_2807692_2	1205680.CAKO01000008_gene4086	1.501e-170	544.0	COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,2TRWV@28211|Alphaproteobacteria,2JR5W@204441|Rhodospirillales	28211|Alphaproteobacteria	E	Periplasmic binding protein	MA20_27930	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_2807692_8	1089551.KE386572_gene3392	4.036e-102	338.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2TSWQ@28211|Alphaproteobacteria,4BS6Z@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	MA20_27855	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_2807692_7	1380394.JADL01000003_gene5075	1.864e-107	355.0	COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2TTCE@28211|Alphaproteobacteria,2JQIS@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_2807692_16	243164.DET1552	0.000885	46.0	COG1961@1|root,COG1961@2|Bacteria,2G7BH@200795|Chloroflexi,34DMJ@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_2807692_13	582899.Hden_0029	9.892e-37	141.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2UC5G@28211|Alphaproteobacteria,3N91P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the bacterial histone-like protein family	hupA	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_2807692_1	670307.HYPDE_35323	1.782e-196	627.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,3N66Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K03732,ko:K11927	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
TLS2_k127_2807692_15	78245.Xaut_1466	1.104e-18	91.0	2CAZC@1|root,32ZW8@2|Bacteria,1N86F@1224|Proteobacteria,2UGV9@28211|Alphaproteobacteria,3EZX6@335928|Xanthobacteraceae	28211|Alphaproteobacteria	-	-	MA20_22075	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2807692_6	1333998.M2A_2073	9.241e-120	400.0	COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,2TSKZ@28211|Alphaproteobacteria,4BQ3B@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	V	MatE	dinF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
TLS2_k127_2807692_3	1267005.KB911265_gene3633	4.293e-148	479.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2TRF8@28211|Alphaproteobacteria,3N6G1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TLS2_k127_2807692_14	426117.M446_3257	1.038e-32	132.0	COG3502@1|root,COG3502@2|Bacteria,1MZEQ@1224|Proteobacteria,2UBR3@28211|Alphaproteobacteria,1JV7H@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF952)	MA20_22095	-	-	-	-	-	-	-	-	-	-	-	DUF952
TLS2_k127_2807692_11	991905.SL003B_3261	1.003e-43	167.0	COG2932@1|root,COG2932@2|Bacteria,1MXWS@1224|Proteobacteria,2TQJE@28211|Alphaproteobacteria,4BQF4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	peptidase	c1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
TLS2_k127_2807692_12	1121106.JQKB01000016_gene5355	2.826e-42	157.0	2AJ2R@1|root,319M2@2|Bacteria,1RJXB@1224|Proteobacteria,2UA6I@28211|Alphaproteobacteria,2JY06@204441|Rhodospirillales	204441|Rhodospirillales	S	Conserved hypothetical protein (Lin0512_fam)	-	-	-	-	-	-	-	-	-	-	-	-	Lin0512_fam
TLS2_k127_2807894_8	331869.BAL199_05439	2.943e-76	256.0	COG3791@1|root,COG3791@2|Bacteria,1RFBP@1224|Proteobacteria,2U7YA@28211|Alphaproteobacteria,4BQZ3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS2_k127_2807894_2	717785.HYPMC_1926	1.812e-178	574.0	COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2TSSE@28211|Alphaproteobacteria,3N7IU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Malonyl-CoA decarboxylase	matA	-	4.1.1.9	ko:K01578	ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152	-	R00233	RC00040	ko00000,ko00001,ko01000	-	-	-	MCD,MCD_N
TLS2_k127_2807894_7	1353528.DT23_16560	1.2e-90	305.0	COG0491@1|root,COG0491@2|Bacteria,1MUT2@1224|Proteobacteria,2TRG9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	MA20_14090	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_2807894_4	1120956.JHZK01000013_gene2605	7.311e-141	458.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,2TQVT@28211|Alphaproteobacteria,1JNU5@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_2807894_10	1120956.JHZK01000010_gene2763	1.003e-53	198.0	COG3090@1|root,COG3090@2|Bacteria,1N9D4@1224|Proteobacteria,2U96V@28211|Alphaproteobacteria,1JPIP@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_2807894_1	398580.Dshi_1482	2.601e-183	583.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_2807894_3	1267005.KB911255_gene2934	1.045e-141	463.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2TQWA@28211|Alphaproteobacteria,3N64R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase subunit III	ctaE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
TLS2_k127_2807894_9	1333998.M2A_1516	4.885e-70	243.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2U6ZT@28211|Alphaproteobacteria,4BQCN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I	ctaG	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
TLS2_k127_2807894_12	402881.Plav_0672	3.592e-07	53.0	2EGEY@1|root,310BN@2|Bacteria,1Q6BN@1224|Proteobacteria,2VCHD@28211|Alphaproteobacteria,1JPJU@119043|Rhodobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2807894_5	1267005.KB911255_gene2931	7.016e-126	411.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2TRD8@28211|Alphaproteobacteria,3N6K8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
TLS2_k127_2807894_0	1267005.KB911255_gene2930	5.449e-307	945.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,3N6KY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS2_k127_2807894_6	1267005.KB911255_gene2929	3.472e-110	365.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2TRK6@28211|Alphaproteobacteria,3N6MH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
TLS2_k127_2807894_11	382640.BT_1890	1.074e-17	84.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2U5E5@28211|Alphaproteobacteria,48TUM@772|Bartonellaceae	28211|Alphaproteobacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
TLS2_k127_2813681_7	1380394.JADL01000001_gene2652	9.709e-127	413.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TRPK@28211|Alphaproteobacteria,2JQGR@204441|Rhodospirillales	204441|Rhodospirillales	E	Aminotransferase	aatA	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_2813681_12	331869.BAL199_18396	6.966e-63	227.0	COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,2TVBS@28211|Alphaproteobacteria,4BSDB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Domain of unknown function (DUF1932)	MA20_26655	-	-	-	-	-	-	-	-	-	-	-	DUF1932,NAD_binding_2
TLS2_k127_2813681_1	1217720.ALOX01000008_gene1785	1.815e-257	804.0	COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,2TSEQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	Amino_oxidase,FAD_binding_3,Pyr_redox_2
TLS2_k127_2813681_11	1267005.KB911255_gene2447	1.101e-63	234.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2U0NP@28211|Alphaproteobacteria,3N6XY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
TLS2_k127_2813681_9	648757.Rvan_0145	1.051e-92	314.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2TR79@28211|Alphaproteobacteria,3N6MN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispA	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009536,GO:0009842,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033385,GO:0033386,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0090407,GO:1901576	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_2813681_6	1411123.JQNH01000001_gene3804	2.973e-139	453.0	COG0045@1|root,COG0045@2|Bacteria,1R3UY@1224|Proteobacteria,2TVQC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the succinate malate CoA ligase beta subunit family	-	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
TLS2_k127_2813681_8	1411123.JQNH01000001_gene3803	6.234e-126	419.0	COG0074@1|root,COG0074@2|Bacteria,1PY0K@1224|Proteobacteria,2U0IA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	-	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
TLS2_k127_2813681_13	1267005.KB911260_gene3580	1.466e-58	222.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2U79T@28211|Alphaproteobacteria,3N8TF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_2813681_10	1267005.KB911260_gene3528	9.412e-79	267.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2U5BZ@28211|Alphaproteobacteria,3N6U2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_2813681_3	1207063.P24_14249	6.394e-170	538.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,2JPRD@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the ABC transporter superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
TLS2_k127_2813681_4	331869.BAL199_03914	8.69e-169	535.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,4BRBM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0444 ABC-type dipeptide oligopeptide nickel transport system, ATPase component	MA20_20680	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_2813681_5	1207063.P24_14239	5.244e-152	485.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2TTEV@28211|Alphaproteobacteria,2JVNR@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1,OppC_N
TLS2_k127_2813681_2	1502851.FG93_04288	4.814e-170	537.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TSF3@28211|Alphaproteobacteria,3JQWP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	appB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_2813681_0	1207063.P24_14229	1.679e-302	937.0	COG0747@1|root,COG0747@2|Bacteria,1MUP8@1224|Proteobacteria,2TQXX@28211|Alphaproteobacteria,2JZHD@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_2828097_16	935840.JAEQ01000001_gene2668	2.48e-07	53.0	COG0782@1|root,COG0782@2|Bacteria,1MZNY@1224|Proteobacteria,2UC6B@28211|Alphaproteobacteria,43KQT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Transcription elongation factor	rnk	-	-	ko:K06140	-	-	-	-	ko00000,ko03000	-	-	-	GreA_GreB,Rnk_N
TLS2_k127_2828097_12	935840.JAEQ01000001_gene2669	3.25e-34	137.0	COG0782@1|root,COG0782@2|Bacteria,1NJQ8@1224|Proteobacteria,2UN89@28211|Alphaproteobacteria,43KIK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus	-	-	-	ko:K06140	-	-	-	-	ko00000,ko03000	-	-	-	GreA_GreB
TLS2_k127_2828097_17	1151061.CAJY01000028_gene1158	0.0007961	44.0	COG0642@1|root,COG2205@2|Bacteria,2I3JI@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_2828097_11	420324.KI912082_gene6957	5.084e-35	136.0	COG0596@1|root,COG0596@2|Bacteria,1MWVN@1224|Proteobacteria,2TQVB@28211|Alphaproteobacteria,1JUZ2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Epoxide hydrolase N terminus	-	-	3.3.2.9	ko:K01253,ko:K21159	ko00980,ko01059,ko04976,ko05204,map00980,map01059,map04976,map05204	-	R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443	RC01447,RC01728,RC01764,RC02528	ko00000,ko00001,ko01000,ko01002	-	-	-	EHN
TLS2_k127_2828097_10	1380355.JNIJ01000013_gene282	5.639e-37	146.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3K066@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110
TLS2_k127_2828097_7	1469245.JFBG01000054_gene2107	2.203e-112	374.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,1RQN1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TRAP transporter solute receptor TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
TLS2_k127_2828097_0	1469245.JFBG01000054_gene2106	3.824e-232	737.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_2828097_1	1121106.JQKB01000011_gene370	3.359e-204	649.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQK7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_2828097_5	1429916.X566_03135	1.426e-124	406.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TTTE@28211|Alphaproteobacteria,3JTB8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	MA20_19385	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_2828097_6	1429916.X566_03130	3.573e-115	378.0	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,2TUUP@28211|Alphaproteobacteria,3JVE9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	MA20_19380	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_2828097_3	1121106.JQKB01000163_gene3936	1.318e-137	445.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	MA20_19370	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_2828097_4	1121861.KB899922_gene3106	2.909e-133	438.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2JUY6@204441|Rhodospirillales	204441|Rhodospirillales	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_2828097_2	1380394.JADL01000001_gene2544	1.705e-179	578.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TUKZ@28211|Alphaproteobacteria,2JZ9Y@204441|Rhodospirillales	204441|Rhodospirillales	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_2828097_8	570952.ATVH01000017_gene1640	2.239e-56	211.0	COG0329@1|root,COG0329@2|Bacteria,1R73B@1224|Proteobacteria,2U0S8@28211|Alphaproteobacteria,2JXE5@204441|Rhodospirillales	204441|Rhodospirillales	EM	Dihydrodipicolinate synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	DHDPS
TLS2_k127_2828097_14	272568.GDI0196	2.8e-08	61.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TUKZ@28211|Alphaproteobacteria,2JW8Z@204441|Rhodospirillales	204441|Rhodospirillales	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_2828097_13	1280947.HY30_18855	4.739e-29	120.0	COG3666@1|root,COG3666@2|Bacteria,1Q0SP@1224|Proteobacteria,2VARX@28211|Alphaproteobacteria,440BI@69657|Hyphomonadaceae	28211|Alphaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2828097_9	1429916.X566_15070	2.93e-42	157.0	COG2141@1|root,COG2141@2|Bacteria,1MVMB@1224|Proteobacteria,2U1EV@28211|Alphaproteobacteria,3JW4H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_2862590_1	717785.HYPMC_0547	1.501e-135	440.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2TRSH@28211|Alphaproteobacteria,3N6AB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_2862590_2	1267005.KB911265_gene3592	6.113e-121	393.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2TQN2@28211|Alphaproteobacteria,3N6A2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
TLS2_k127_2862590_0	648757.Rvan_0907	1.771e-222	696.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2TSHK@28211|Alphaproteobacteria,3N61T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_2870316_2	1502851.FG93_05335	2.595e-21	95.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,3JR8U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
TLS2_k127_2870316_3	511062.GU3_14270	2.508e-13	75.0	COG0784@1|root,COG2200@1|root,COG0784@2|Bacteria,COG2200@2|Bacteria,1NC9X@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	vieA	-	3.1.4.52	ko:K13246	ko05111,map05111	-	R08991	RC00296	ko00000,ko00001,ko01000	-	-	-	EAL,GerE,Response_reg
TLS2_k127_2870316_1	648885.KB316282_gene2096	7.576e-66	243.0	COG4961@1|root,COG4961@2|Bacteria,1RA6J@1224|Proteobacteria,2U6PB@28211|Alphaproteobacteria,1JSDA@119045|Methylobacteriaceae	28211|Alphaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
TLS2_k127_2870316_0	426117.M446_5358	9.837e-121	413.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TWG2@28211|Alphaproteobacteria,1JSYM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K07647,ko:K07678	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00455,M00475	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE8,EAL,HAMP,HATPase_c,HisKA,Hpt,Response_reg
TLS2_k127_2870901_3	1110502.TMO_1814	5.461e-22	102.0	COG5452@1|root,COG5452@2|Bacteria,1N12T@1224|Proteobacteria,2UCES@28211|Alphaproteobacteria,2JTNK@204441|Rhodospirillales	204441|Rhodospirillales	S	Ubiquinol-cytochrome C chaperone	-	-	-	ko:K17662	-	-	-	-	ko00000,ko03029	-	-	-	Ubiq_cyt_C_chap
TLS2_k127_2870901_2	648757.Rvan_1305	2.029e-37	148.0	COG2913@1|root,COG2913@2|Bacteria,1Q3I4@1224|Proteobacteria,2VABI@28211|Alphaproteobacteria,3N7DX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	SmpA / OmlA family	-	-	-	-	-	-	-	-	-	-	-	-	SmpA_OmlA
TLS2_k127_2870901_0	1267005.KB911255_gene2978	3.597e-178	561.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2TS2N@28211|Alphaproteobacteria,3N6C6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
TLS2_k127_2870901_1	1267005.KB911255_gene2980	4.975e-117	387.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria,3N6GH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
TLS2_k127_2880342_22	648885.KB316284_gene4942	2.253e-14	74.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,1JSKU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	MA20_26850	-	-	ko:K18299,ko:K18902	-	M00641,M00698	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.16	-	-	ACR_tran
TLS2_k127_2880342_4	1126627.BAWE01000004_gene4069	1.243e-208	654.0	COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria,3JWB9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP,TAT_signal
TLS2_k127_2880342_14	1126627.BAWE01000004_gene4068	2.257e-95	317.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2U4QB@28211|Alphaproteobacteria,3JRDA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_2880342_3	1380355.JNIJ01000010_gene1441	1.935e-209	659.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,3JTY7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_2880342_6	1038859.AXAU01000008_gene2022	6.469e-187	596.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,3JVBW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_2880342_23	1380355.JNIJ01000010_gene1439	7.626e-08	59.0	2BIVE@1|root,32D3G@2|Bacteria,1NMSZ@1224|Proteobacteria,2UKYH@28211|Alphaproteobacteria,3K274@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2880342_16	582899.Hden_2739	2.422e-87	308.0	COG2885@1|root,COG2885@2|Bacteria,1PQ3A@1224|Proteobacteria,2TRBD@28211|Alphaproteobacteria,3N6W1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	OmpA family	MA20_43500	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS2_k127_2880342_18	469371.Tbis_2522	5.19e-62	228.0	COG2141@1|root,COG2141@2|Bacteria,2GKP1@201174|Actinobacteria,4EEF0@85010|Pseudonocardiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_2880342_1	582899.Hden_3441	3.356e-220	709.0	COG0683@1|root,COG0683@2|Bacteria,1R6QM@1224|Proteobacteria,2U0C6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
TLS2_k127_2880342_5	52598.EE36_10759	3.435e-200	635.0	COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,2TR5N@28211|Alphaproteobacteria,3ZVI6@60136|Sulfitobacter	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	MA20_04440	-	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
TLS2_k127_2880342_0	359.CN09_29915	1.262e-287	898.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4B72Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,MHYT
TLS2_k127_2880342_17	1123060.JONP01000009_gene2094	1.782e-70	258.0	COG0726@1|root,COG0726@2|Bacteria,1R8C6@1224|Proteobacteria,2U0HC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
TLS2_k127_2880342_15	1037409.BJ6T_41020	1.491e-87	298.0	COG1737@1|root,COG1737@2|Bacteria,1MW2B@1224|Proteobacteria,2TV88@28211|Alphaproteobacteria,3K0NS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Helix-turn-helix domain, rpiR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
TLS2_k127_2880342_2	1037409.BJ6T_41030	1.026e-217	683.0	COG0683@1|root,COG0683@2|Bacteria,1N11P@1224|Proteobacteria,2TRQ4@28211|Alphaproteobacteria,3JVI6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_2880342_8	1038859.AXAU01000013_gene6513	1.665e-155	495.0	COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2U0TW@28211|Alphaproteobacteria,3JUC4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_2880342_9	1038859.AXAU01000013_gene6514	2.019e-148	479.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VF1H@28211|Alphaproteobacteria,3K6D7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_2880342_11	1038859.AXAU01000013_gene6515	2.037e-111	370.0	COG0411@1|root,COG0411@2|Bacteria,1MXHT@1224|Proteobacteria,2TSWS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0411 ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_2880342_12	1038859.AXAU01000013_gene6516	1.295e-109	372.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2TSWQ@28211|Alphaproteobacteria,3JUT4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_2880342_13	1037409.BJ6T_41080	7.527e-101	336.0	COG1131@1|root,COG1131@2|Bacteria,1NT51@1224|Proteobacteria,2UPEH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_2880342_20	1267005.KB911259_gene3924	3.068e-24	113.0	2EE49@1|root,337YY@2|Bacteria,1NE01@1224|Proteobacteria	1224|Proteobacteria	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
TLS2_k127_2880342_21	1188252.AJYK01000072_gene2099	1.999e-17	93.0	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S90Z@1236|Gammaproteobacteria,1XXSJ@135623|Vibrionales	135623|Vibrionales	C	COG2863 Cytochrome c553	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
TLS2_k127_2880342_10	1125973.JNLC01000015_gene3350	1.603e-131	426.0	2A2TX@1|root,30R7T@2|Bacteria,1R3BI@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3829)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3829
TLS2_k127_2880342_7	1207063.P24_03850	6.258e-170	546.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2JVM4@204441|Rhodospirillales	204441|Rhodospirillales	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_2880342_19	314231.FP2506_13354	1.829e-39	153.0	COG3090@1|root,COG3090@2|Bacteria,1PJMG@1224|Proteobacteria,2V8SP@28211|Alphaproteobacteria,2PMD2@255475|Aurantimonadaceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_2880358_2	1297569.MESS2_100016	1.216e-61	218.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2TRNV@28211|Alphaproteobacteria,43INJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
TLS2_k127_2880358_3	670307.HYPDE_37973	7.89e-20	94.0	COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,2UFJJ@28211|Alphaproteobacteria,3N9H3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	atpI	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
TLS2_k127_2880358_1	1082933.MEA186_31446	5.56e-115	379.0	COG2267@1|root,COG2267@2|Bacteria,1QTYM@1224|Proteobacteria,2TX65@28211|Alphaproteobacteria,43J6R@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_2880358_0	1230476.C207_04885	1.875e-266	827.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TTE1@28211|Alphaproteobacteria,3JVIN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
TLS2_k127_2883505_5	388399.SSE37_21550	1.071e-93	313.0	COG1529@1|root,COG1529@2|Bacteria,1NNFR@1224|Proteobacteria,2TVHX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	MA20_13965	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_2883505_0	388399.SSE37_21545	3.684e-191	606.0	COG1529@1|root,COG1529@2|Bacteria,1NPGE@1224|Proteobacteria,2TTCC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	MA20_13970	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C2
TLS2_k127_2883505_1	388399.SSE37_21540	2.138e-154	490.0	COG0714@1|root,COG0714@2|Bacteria,1NWIN@1224|Proteobacteria,2TTPB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	AAA domain (dynein-related subfamily)	MA20_13975	-	-	-	-	-	-	-	-	-	-	-	AAA_5
TLS2_k127_2883505_2	388399.SSE37_21535	8.277e-140	458.0	COG3552@1|root,COG3552@2|Bacteria,1MUEJ@1224|Proteobacteria,2TQQT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein containing von Willebrand factor type A (VWA) domain	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS2_k127_2883505_3	388399.SSE37_21530	1.615e-119	394.0	COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,2TRQX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_2883505_4	388399.SSE37_21525	3.689e-101	333.0	COG0491@1|root,COG0491@2|Bacteria,1Q8EW@1224|Proteobacteria,2TUW0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	MA20_13990	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_2885559_15	1088721.NSU_2595	7.137e-49	192.0	COG3614@1|root,COG3920@1|root,COG3614@2|Bacteria,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2U4QM@28211|Alphaproteobacteria,2K26R@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HWE_HK
TLS2_k127_2885559_4	670307.HYPDE_25018	3.847e-122	416.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2TV5E@28211|Alphaproteobacteria,3N8G6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport,GAF
TLS2_k127_2885559_20	670307.HYPDE_37068	3.519e-22	96.0	COG5487@1|root,COG5487@2|Bacteria	2|Bacteria	S	UPF0391 membrane protein	MA20_02060	-	-	-	-	-	-	-	-	-	-	-	DUF1328
TLS2_k127_2885559_11	1267005.KB911255_gene2773	4.091e-74	269.0	COG3596@1|root,COG3596@2|Bacteria,1P6GT@1224|Proteobacteria,2UAIT@28211|Alphaproteobacteria,3N8AE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	50S ribosome-binding GTPase	-	-	-	ko:K06946	-	-	-	-	ko00000	-	-	-	MMR_HSR1
TLS2_k127_2885559_14	395963.Bind_3241	8.172e-58	209.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2TUUZ@28211|Alphaproteobacteria,3NAJW@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	Sigma-70 region 2	sigH	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2885559_8	1120956.JHZK01000005_gene2362	6.776e-92	309.0	COG0784@1|root,COG0784@2|Bacteria,1MX3Y@1224|Proteobacteria,2TT2R@28211|Alphaproteobacteria,1JN3X@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	phyR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Sigma70_r4_2
TLS2_k127_2885559_17	1210884.HG799464_gene11085	4.352e-34	151.0	COG2202@1|root,COG2203@1|root,COG4191@1|root,COG5000@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.11.1,2.7.13.3	ko:K03407,ko:K10909,ko:K12132	ko02020,ko02024,ko02030,ko05111,map02020,map02024,map02030,map05111	M00506,M00513	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	EAL,GAF_2,GGDEF,GerE,HAMP,HATPase_c,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_8,PAS_9,dCache_1
TLS2_k127_2885559_10	1041159.AZUW01000020_gene1337	1.004e-78	287.0	COG1352@1|root,COG2201@1|root,COG2433@1|root,COG3920@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2433@2|Bacteria,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2TW1K@28211|Alphaproteobacteria,4BB0U@82115|Rhizobiaceae	28211|Alphaproteobacteria	NT	Protein-glutamate methylesterase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HWE_HK,PAS_10,PAS_3,PAS_4,PAS_9
TLS2_k127_2885559_18	189753.AXAS01000067_gene5048	5.442e-33	147.0	COG4126@1|root,COG4126@2|Bacteria,1MVNB@1224|Proteobacteria,2U28G@28211|Alphaproteobacteria,3JVNQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Asp/Glu/Hydantoin racemase	hyuE	-	5.1.99.3	ko:K16841	ko00230,ko01120,map00230,map01120	-	R03925	RC01027	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
TLS2_k127_2885559_1	1217720.ALOX01000087_gene3045	1.399e-183	582.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TUHU@28211|Alphaproteobacteria,2JQ08@204441|Rhodospirillales	204441|Rhodospirillales	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_2885559_12	257310.BB0974	6.862e-73	275.0	COG2084@1|root,COG2084@2|Bacteria,1MWR4@1224|Proteobacteria,2VQK0@28216|Betaproteobacteria,3T6M5@506|Alcaligenaceae	28216|Betaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_2885559_13	366602.Caul_0930	3.451e-59	233.0	2CJVH@1|root,2Z82D@2|Bacteria,1MX2M@1224|Proteobacteria,2TTCY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_19455	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_2885559_6	1380394.JADL01000001_gene2250	5.713e-103	341.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TY37@28211|Alphaproteobacteria,2JPTA@204441|Rhodospirillales	204441|Rhodospirillales	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_2885559_2	1037409.BJ6T_24010	1.729e-168	537.0	COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,2TS6M@28211|Alphaproteobacteria,3JV9F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Peptidase dimerisation domain	MA20_11215	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_2885559_0	1267005.KB911255_gene2965	8.439e-209	663.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,3N6GN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	ybaL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
TLS2_k127_2885559_5	1205680.CAKO01000005_gene3527	1.112e-111	366.0	COG2513@1|root,COG2513@2|Bacteria,1R3SD@1224|Proteobacteria,2TRRV@28211|Alphaproteobacteria,2JR17@204441|Rhodospirillales	204441|Rhodospirillales	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
TLS2_k127_2885559_9	384765.SIAM614_16517	2.196e-91	321.0	COG4249@1|root,COG4249@2|Bacteria,1MXFD@1224|Proteobacteria,2TRW5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Peptidase C14 caspase catalytic subunit p20	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	PG_binding_1,Peptidase_C14,Sel1
TLS2_k127_2885559_16	1123508.JH636447_gene7846	5.302e-45	170.0	COG0346@1|root,COG0346@2|Bacteria,2J36B@203682|Planctomycetes	203682|Planctomycetes	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2885559_7	1288298.rosmuc_02784	2.552e-100	331.0	COG0243@1|root,COG0243@2|Bacteria,1MWPS@1224|Proteobacteria,2TVFQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	PFAM molybdopterin oxidoreductase Fe4S4 region	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,TAT_signal
TLS2_k127_2885559_3	991905.SL003B_1279	2.378e-134	431.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2TTPX@28211|Alphaproteobacteria,4BT8J@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TLS2_k127_2886708_23	34007.IT40_21720	0.0002839	44.0	COG1951@1|root,COG1951@2|Bacteria,1MW8J@1224|Proteobacteria,2U0X2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1951 Tartrate dehydratase alpha subunit Fumarate hydratase class I, N-terminal domain	ttdA	-	4.2.1.2,4.2.1.32	ko:K01677,ko:K03779	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
TLS2_k127_2886708_6	1123504.JQKD01000012_gene1284	2.668e-132	428.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2VM5F@28216|Betaproteobacteria,4ABQW@80864|Comamonadaceae	28216|Betaproteobacteria	E	HMGL-like	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like
TLS2_k127_2886708_8	1267005.KB911258_gene622	8.529e-99	327.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2TT7W@28211|Alphaproteobacteria,3N675@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
TLS2_k127_2886708_3	402881.Plav_2837	1.427e-188	604.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQU2@28211|Alphaproteobacteria,1JN9N@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	aidB	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
TLS2_k127_2886708_18	717785.HYPMC_4628	4.305e-35	139.0	COG1846@1|root,COG1846@2|Bacteria,1RJRY@1224|Proteobacteria,2UA4D@28211|Alphaproteobacteria,3N8VY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_2886708_15	1040989.AWZU01000012_gene1428	1.879e-50	187.0	COG2166@1|root,COG2166@2|Bacteria,1RI8F@1224|Proteobacteria,2U9A2@28211|Alphaproteobacteria,3JY1C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Fe-S metabolism associated domain	sufE	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
TLS2_k127_2886708_5	460265.Mnod_1031	1.448e-146	473.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TW14@28211|Alphaproteobacteria,1JSD2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	aromatic amino acid beta-eliminating lyase threonine aldolase	metB	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS2_k127_2886708_13	1502851.FG93_03034	1.239e-60	215.0	2A97H@1|root,30YC7@2|Bacteria,1RE59@1224|Proteobacteria,2URCX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2886708_11	582899.Hden_3367	5.085e-76	267.0	COG0500@1|root,COG2226@2|Bacteria,1PN45@1224|Proteobacteria,2U64U@28211|Alphaproteobacteria,3N9ET@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_2886708_17	1267005.KB911256_gene1936	1.383e-41	158.0	COG2340@1|root,COG2340@2|Bacteria,1RK26@1224|Proteobacteria,2V7AB@28211|Alphaproteobacteria,3N9BY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
TLS2_k127_2886708_9	1267005.KB911257_gene936	2.917e-86	296.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2TRPD@28211|Alphaproteobacteria,3N9HQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Reversible hydration of carbon dioxide	cynT	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS2_k127_2886708_22	670307.HYPDE_33868	5.419e-07	54.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,3N68D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_2886708_7	1121861.KB899931_gene92	1.042e-115	398.0	COG0464@1|root,COG0464@2|Bacteria,1NF48@1224|Proteobacteria,2TV2U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	AAA ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA
TLS2_k127_2886708_19	1041147.AUFB01000026_gene5974	4.642e-24	114.0	COG0784@1|root,COG0784@2|Bacteria,1MX3Y@1224|Proteobacteria,2UG1V@28211|Alphaproteobacteria,4BG0R@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_2886708_10	1267005.KB911256_gene1742	2.974e-78	282.0	COG3920@1|root,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2VF43@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	two component sensor kinase	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK
TLS2_k127_2886708_2	717785.HYPMC_2883	1.013e-231	729.0	COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,2TQTR@28211|Alphaproteobacteria,3N65C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Zn-dependent metallo-hydrolase RNA specificity domain	rnjA	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
TLS2_k127_2886708_14	1267005.KB911256_gene1842	1.974e-52	194.0	COG0340@1|root,COG0340@2|Bacteria,1MWCC@1224|Proteobacteria,2TS82@28211|Alphaproteobacteria,3N70S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Biotin protein ligase C terminal domain	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
TLS2_k127_2886708_4	1267005.KB911256_gene1840	4.613e-183	584.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2TQMX@28211|Alphaproteobacteria,3N6I1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_2886708_1	670307.HYPDE_28903	3.669e-255	797.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2TSNK@28211|Alphaproteobacteria,3N6M4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NADH-quinone oxidoreductase chain	nuoM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
TLS2_k127_2886708_0	1267005.KB911256_gene1838	0.0	1024.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,3N6EE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CP	NADH-quinone oxidoreductase chain L	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
TLS2_k127_2886708_20	391603.FBALC1_15302	1.347e-23	104.0	COG0346@1|root,COG0346@2|Bacteria,4NSWT@976|Bacteroidetes,1I4YP@117743|Flavobacteriia	976|Bacteroidetes	E	Glyoxalase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_2886708_16	331869.BAL199_25449	5.143e-46	167.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,2U93P@28211|Alphaproteobacteria,4BQGZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS2_k127_2886708_12	1267005.KB911256_gene1836	5.33e-71	246.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2TRB2@28211|Alphaproteobacteria,3N6QS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS2_k127_2886708_21	717785.HYPMC_2890	4.846e-10	59.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2TRFE@28211|Alphaproteobacteria,3N6JA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3,1.6.99.3	ko:K00338,ko:K03941	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	Fer4
TLS2_k127_289039_3	1267005.KB911259_gene4023	1.599e-52	191.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TRQ7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_289039_4	1040989.AWZU01000040_gene6008	3.705e-15	79.0	COG0454@1|root,COG0456@2|Bacteria,1RIAQ@1224|Proteobacteria,2UEAD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
TLS2_k127_289039_1	1123368.AUIS01000003_gene1781	3.039e-70	253.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RYH1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Acts as a magnesium transporter	mgtE-1	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
TLS2_k127_289039_6	1538295.JY96_04175	7.741e-08	57.0	COG0530@1|root,COG0530@2|Bacteria,1PW8G@1224|Proteobacteria,2VMK4@28216|Betaproteobacteria,1KKKP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
TLS2_k127_289039_5	314271.RB2654_19843	7.717e-08	57.0	COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,2U632@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	2-hydroxychromene-2-carboxylate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
TLS2_k127_289039_0	1282876.BAOK01000002_gene565	6.141e-171	543.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria,4BPRI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TLS2_k127_289039_2	314278.NB231_12094	8.776e-61	215.0	COG0454@1|root,COG0456@2|Bacteria,1RIAQ@1224|Proteobacteria	1224|Proteobacteria	K	N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
TLS2_k127_2899563_9	1126627.BAWE01000004_gene4213	1.613e-54	193.0	COG1028@1|root,COG1028@2|Bacteria,1MUPX@1224|Proteobacteria,2TT6C@28211|Alphaproteobacteria,3JS1C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	MA20_30510	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_2899563_3	331869.BAL199_24329	8.213e-175	561.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS2_k127_2899563_10	1122132.AQYH01000010_gene4105	5.552e-27	115.0	COG3070@1|root,COG3070@2|Bacteria,1N8X8@1224|Proteobacteria,2UFNC@28211|Alphaproteobacteria,4BFM8@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	regulator of competence-specific genes	MA20_30690	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
TLS2_k127_2899563_2	1205680.CAKO01000004_gene3635	8.084e-260	812.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_2899563_7	1121861.KB899912_gene1124	2.242e-94	313.0	2AGFQ@1|root,316N0@2|Bacteria,1RKGQ@1224|Proteobacteria,2U90Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2899563_5	426117.M446_5353	5.471e-168	537.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2TR5X@28211|Alphaproteobacteria,1JRH2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	TIGRFAM amidase, hydantoinase carbamoylase family	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_M20
TLS2_k127_2899563_8	1267005.KB911263_gene1375	3.347e-70	245.0	COG3816@1|root,COG3816@2|Bacteria,1RD5Q@1224|Proteobacteria,2U7DA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	MA20_44640	-	-	ko:K09986	-	-	-	-	ko00000	-	-	-	DUF1285
TLS2_k127_2899563_4	1267005.KB911263_gene1376	1.931e-172	547.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2TR0T@28211|Alphaproteobacteria,3N6FK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ATPase AAA	moxR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_2899563_6	1267005.KB911263_gene1377	3.081e-122	402.0	COG1721@1|root,COG1721@2|Bacteria,1MWPG@1224|Proteobacteria,2TTDX@28211|Alphaproteobacteria,3N7PV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function DUF58	MA20_44650	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_2899563_0	1267005.KB911263_gene1378	0.0	1141.0	28H8H@1|root,2Z7KE@2|Bacteria,1MV77@1224|Proteobacteria,2TSVV@28211|Alphaproteobacteria,3N7SW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4159)	MA20_44655	-	-	-	-	-	-	-	-	-	-	-	BatA,DUF4159
TLS2_k127_2899563_1	1267005.KB911263_gene1379	2.457e-308	959.0	COG5426@1|root,COG5426@2|Bacteria,1MVWA@1224|Proteobacteria,2TQNQ@28211|Alphaproteobacteria,3N89S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	membrane	MA20_44660	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
TLS2_k127_2900029_8	1123503.KB908056_gene1952	1.138e-28	124.0	COG1846@1|root,COG1846@2|Bacteria,1RJPG@1224|Proteobacteria,2TUJP@28211|Alphaproteobacteria,2KGQ2@204458|Caulobacterales	204458|Caulobacterales	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_2900029_6	438753.AZC_0574	2.482e-52	196.0	COG0583@1|root,COG0583@2|Bacteria,1MWVB@1224|Proteobacteria,2TQXV@28211|Alphaproteobacteria,3F10F@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	PFAM regulatory protein LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_2900029_0	1267005.KB911258_gene465	1.069e-236	736.0	COG0538@1|root,COG0538@2|Bacteria,1MUIB@1224|Proteobacteria,2TQWD@28211|Alphaproteobacteria,3N6AW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the isocitrate and isopropylmalate dehydrogenases family	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_2900029_3	1267005.KB911257_gene757	1.219e-133	434.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,3N7R0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_2900029_1	1267005.KB911257_gene758	3.909e-217	689.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,3N65J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS2_k127_2900029_4	1267005.KB911257_gene759	6.973e-90	305.0	COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,2TV8S@28211|Alphaproteobacteria,3N6MZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length	fabA	-	4.2.1.59,5.3.3.14	ko:K01716	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639	RC00831,RC01078,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
TLS2_k127_2900029_2	717785.HYPMC_4657	8.393e-196	617.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2TQT3@28211|Alphaproteobacteria,3N62E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
TLS2_k127_2900029_7	1267005.KB911257_gene860	5.072e-32	137.0	2C8HF@1|root,2ZXE6@2|Bacteria,1R5PH@1224|Proteobacteria,2U64K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_43475	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2902665_7	1380394.JADL01000010_gene4231	5.159e-13	70.0	COG0596@1|root,COG0596@2|Bacteria,1NCX0@1224|Proteobacteria,2UEMT@28211|Alphaproteobacteria,2JXXP@204441|Rhodospirillales	204441|Rhodospirillales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_2902665_1	1205680.CAKO01000037_gene1315	7.911e-138	447.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_2902665_5	570967.JMLV01000001_gene2501	1.483e-69	243.0	COG1802@1|root,COG1802@2|Bacteria,1RKMP@1224|Proteobacteria,2UAUH@28211|Alphaproteobacteria,2JTN9@204441|Rhodospirillales	204441|Rhodospirillales	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_2902665_4	1197906.CAJQ02000043_gene2029	1.945e-112	367.0	COG3000@1|root,COG3000@2|Bacteria,1R4RM@1224|Proteobacteria,2TRCM@28211|Alphaproteobacteria,3JW9S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS2_k127_2902665_2	479432.Sros_5544	1.115e-129	422.0	COG5285@1|root,COG5285@2|Bacteria,2GP1T@201174|Actinobacteria,4EIAH@85012|Streptosporangiales	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS2_k127_2902665_0	420662.Mpe_A3653	1.152e-165	531.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2VHHD@28216|Betaproteobacteria,1KJ5Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	TRAP dicarboxylate transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_2902665_6	570952.ATVH01000018_gene3251	4.584e-46	173.0	COG4665@1|root,COG4665@2|Bacteria,1N1S5@1224|Proteobacteria,2UCSH@28211|Alphaproteobacteria,2JUI7@204441|Rhodospirillales	204441|Rhodospirillales	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_2902665_3	570967.JMLV01000001_gene2502	6.087e-129	421.0	COG4663@1|root,COG4663@2|Bacteria,1PCF8@1224|Proteobacteria,2U0KJ@28211|Alphaproteobacteria,2JVKA@204441|Rhodospirillales	204441|Rhodospirillales	Q	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_2915377_3	717785.HYPMC_2035	1.848e-94	315.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,2TTQS@28211|Alphaproteobacteria,3N6MR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	MA20_27940	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_2915377_0	631454.N177_3416	1.91e-166	529.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TR4W@28211|Alphaproteobacteria,1JNEK@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_2915377_4	1120956.JHZK01000015_gene2993	1.835e-91	308.0	COG2872@1|root,COG2872@2|Bacteria,1MY0P@1224|Proteobacteria,2TRRW@28211|Alphaproteobacteria,1JNUN@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Threonyl and Alanyl tRNA synthetase second additional domain	alaS2	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
TLS2_k127_2915377_2	670307.HYPDE_28718	1.796e-111	376.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2TR9R@28211|Alphaproteobacteria,3N6EB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Rhodanese Homology Domain	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS2_k127_2915377_5	1532557.JL37_23425	1.659e-82	288.0	COG3386@1|root,COG3386@2|Bacteria,1MVQM@1224|Proteobacteria,2W1Y7@28216|Betaproteobacteria	28216|Betaproteobacteria	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	-	-	-	-	-	-	-	-	-	SGL
TLS2_k127_2915377_6	1123355.JHYO01000014_gene1005	1.742e-82	289.0	COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,2TSYY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_2915377_1	331869.BAL199_08663	8.046e-123	404.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2TU3A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	mandelate racemase muconate lactonizing	-	-	4.2.1.156,4.2.1.42	ko:K20023	ko00053,map00053	-	R05608	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_2915377_7	1382303.JPOM01000001_gene504	9.571e-19	94.0	COG0189@1|root,COG4067@1|root,COG0189@2|Bacteria,COG4067@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria,2KFBJ@204458|Caulobacterales	204458|Caulobacterales	HJO	Putative ATP-dependant zinc protease	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK,Zn_protease
TLS2_k127_293342_1	1207063.P24_06352	1.098e-273	857.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,2JPG1@204441|Rhodospirillales	204441|Rhodospirillales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	cbbT	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TLS2_k127_293342_46	1254432.SCE1572_24605	1.758e-16	90.0	COG1082@1|root,COG1082@2|Bacteria,1NIQE@1224|Proteobacteria	1224|Proteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_293342_25	717785.HYPMC_4023	8.964e-93	319.0	COG0524@1|root,COG0524@2|Bacteria,1MWX4@1224|Proteobacteria,2VF16@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.184	ko:K18478	-	-	R10970	RC00002,RC00017	ko00000,ko01000	-	-	-	PfkB
TLS2_k127_293342_41	248742.XP_005651743.1	2.347e-26	123.0	29GN1@1|root,2RPUA@2759|Eukaryota,37VVM@33090|Viridiplantae,34HXU@3041|Chlorophyta	3041|Chlorophyta	I	Lipolytic acyl hydrolase (LAH)	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
TLS2_k127_293342_36	1217658.F987_03943	1.55e-53	199.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RM88@1236|Gammaproteobacteria,3NIR4@468|Moraxellaceae	1236|Gammaproteobacteria	I	Fatty acid desaturase	desC	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
TLS2_k127_293342_23	426117.M446_5513	3.792e-103	343.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2TT78@28211|Alphaproteobacteria,1JRU8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TLS2_k127_293342_5	582899.Hden_2644	3.556e-209	659.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2TRFV@28211|Alphaproteobacteria,3N6IF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
TLS2_k127_293342_34	670307.HYPDE_36818	1.488e-62	218.0	COG5480@1|root,COG5480@2|Bacteria,1RISQ@1224|Proteobacteria,2U9NW@28211|Alphaproteobacteria,3N71I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1036)	MA20_03870	-	-	-	-	-	-	-	-	-	-	-	DUF1036
TLS2_k127_293342_17	460265.Mnod_5964	1.553e-129	428.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,2TQJY@28211|Alphaproteobacteria,1JQZ2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	PFAM MOFRL domain protein	MA20_18630	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
TLS2_k127_293342_0	1267005.KB911256_gene1937	0.0	1228.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2TQRQ@28211|Alphaproteobacteria,3N6JR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS2_k127_293342_44	1378168.N510_00390	4.125e-19	98.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes	1239|Firmicutes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_293342_4	631454.N177_2140	2.823e-212	672.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria,1JQ8Q@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_293342_3	1411123.JQNH01000001_gene2591	6.077e-228	719.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_293342_15	1089552.KI911559_gene3264	3.98e-146	468.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR3F@28211|Alphaproteobacteria,2JQU0@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_293342_18	391937.NA2_20881	5.59e-123	415.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2TT4V@28211|Alphaproteobacteria,43IFM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_293342_12	570952.ATVH01000018_gene3328	7.51e-150	494.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2JP9V@204441|Rhodospirillales	204441|Rhodospirillales	EP	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_293342_14	1336243.JAEA01000011_gene3183	1.16e-146	471.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,1JTIX@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	Oligopeptide/dipeptide transporter, C-terminal region	MA20_16745	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_293342_2	1380394.JADL01000013_gene749	3.553e-271	854.0	COG1529@1|root,COG1529@2|Bacteria,1R44B@1224|Proteobacteria,2VF8G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_293342_11	1122132.AQYH01000020_gene200	3.56e-158	510.0	COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,2TS85@28211|Alphaproteobacteria,4B8T6@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Putative sugar-binding N-terminal domain	-	-	2.7.1.217	ko:K21948	-	-	R11706,R11707	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
TLS2_k127_293342_27	1120792.JAFV01000001_gene806	1.841e-90	306.0	COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,2U1NG@28211|Alphaproteobacteria,36Y7M@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
TLS2_k127_293342_21	1304877.KI519399_gene4587	1.518e-115	376.0	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2TSDG@28211|Alphaproteobacteria,3JT3N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	MA20_27185	-	1.1.1.401	ko:K21883	ko00051,ko01120,map00051,map01120	-	R11339	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
TLS2_k127_293342_19	1267005.KB911257_gene1059	5.409e-120	396.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TRUK@28211|Alphaproteobacteria,3N7NX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the peptidase M20A family. ArgE subfamily	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_293342_35	582899.Hden_0024	2.982e-56	200.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2U9JM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	protein affecting Mg2 Co2 transport	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
TLS2_k127_293342_6	717785.HYPMC_4089	3.436e-208	662.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2TQSI@28211|Alphaproteobacteria,3N63A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TLS2_k127_293342_31	648757.Rvan_3057	4.665e-70	258.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,2TS2V@28211|Alphaproteobacteria,3N6SB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	ABC 3 transport family	znuB	GO:0000006,GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0010035,GO:0010038,GO:0010043,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0042221,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
TLS2_k127_293342_9	717785.HYPMC_4428	4.153e-181	577.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2TS98@28211|Alphaproteobacteria,3N66D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
TLS2_k127_293342_24	670292.JH26_22360	3.004e-99	329.0	COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,2TRNQ@28211|Alphaproteobacteria,1JS1W@119045|Methylobacteriaceae	28211|Alphaproteobacteria	IQ	TIGRFAM 3-hydroxybutyrate dehydrogenase	MA20_18175	-	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
TLS2_k127_293342_7	1207063.P24_15701	8.822e-185	589.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TT4A@28211|Alphaproteobacteria,2JRFR@204441|Rhodospirillales	204441|Rhodospirillales	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_293342_8	1267005.KB911256_gene2073	2.384e-182	591.0	COG0664@1|root,COG1752@1|root,COG0664@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria,3N8X3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin,cNMP_binding
TLS2_k127_293342_40	670307.HYPDE_33563	6.934e-35	141.0	COG4731@1|root,COG4731@2|Bacteria,1NHGE@1224|Proteobacteria,2UM5U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
TLS2_k127_293342_28	582899.Hden_1969	1.813e-87	300.0	COG1136@1|root,COG1136@2|Bacteria,1MXVW@1224|Proteobacteria,2U3Z6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_293342_16	670307.HYPDE_28678	8.845e-144	474.0	COG0577@1|root,COG0577@2|Bacteria,1MVSU@1224|Proteobacteria,2TUN8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC transporter permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_293342_22	717785.HYPMC_4842	2.85e-104	351.0	COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,2U5K8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Hydrolase_4
TLS2_k127_293342_33	1267005.KB911265_gene3655	4.844e-67	235.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2TT42@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_293342_20	1267005.KB911265_gene3654	1.349e-116	390.0	COG2114@1|root,COG2114@2|Bacteria,1QWNC@1224|Proteobacteria,2TRQB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	4.6.1.1,4.6.1.2	ko:K01768,ko:K01769	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
TLS2_k127_293342_26	717785.HYPMC_2941	3.138e-91	313.0	COG1566@1|root,COG1566@2|Bacteria,1R7IY@1224|Proteobacteria,2U4ET@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
TLS2_k127_293342_13	1267005.KB911259_gene3818	5.15e-148	495.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2TRTY@28211|Alphaproteobacteria,3N7VX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	cyaD	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
TLS2_k127_293342_39	1267005.KB911256_gene1771	1.421e-38	154.0	COG3712@1|root,COG3712@2|Bacteria,1QW4T@1224|Proteobacteria,2TWMQ@28211|Alphaproteobacteria,3N97T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,OMP_b-brl
TLS2_k127_293342_30	1411123.JQNH01000001_gene2362	2.72e-72	250.0	COG0664@1|root,COG0664@2|Bacteria,1Q93V@1224|Proteobacteria,2TTEY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	cyclic nucleotide-binding	MA20_09210	-	-	-	-	-	-	-	-	-	-	-	Imp-YgjV,cNMP_binding
TLS2_k127_293342_32	1547437.LL06_05125	1.62e-69	247.0	COG0583@1|root,COG0583@2|Bacteria,1MU7H@1224|Proteobacteria,2TS72@28211|Alphaproteobacteria,43MRV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_293342_48	981384.AEYW01000018_gene3188	0.0007783	46.0	COG5457@1|root,COG5457@2|Bacteria,1NGSY@1224|Proteobacteria,2UJV7@28211|Alphaproteobacteria,4NCT0@97050|Ruegeria	28211|Alphaproteobacteria	S	Conserved domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1127
TLS2_k127_293342_38	1267005.KB911258_gene418	3.699e-42	159.0	COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,2TW0S@28211|Alphaproteobacteria,3N7A3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_293342_10	1382303.JPOM01000001_gene333	8.275e-175	564.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2KG83@204458|Caulobacterales	204458|Caulobacterales	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_293342_42	1082931.KKY_2008	4.138e-26	111.0	2DQNQ@1|root,337TP@2|Bacteria,1NFYG@1224|Proteobacteria,2UFD8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_293342_43	1041147.AUFB01000051_gene4048	8.128e-24	105.0	COG3415@1|root,COG3415@2|Bacteria,1RJ69@1224|Proteobacteria,2UB2N@28211|Alphaproteobacteria,4BG9W@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	'Paired box' domain	-	-	-	ko:K07499	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_32,HTH_Tnp_IS630,PAX
TLS2_k127_293342_29	1117943.SFHH103_02919	9.857e-87	291.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,4BC2J@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase and inactivated	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3
TLS2_k127_293342_37	1500301.JQMF01000010_gene2090	6.674e-43	166.0	COG3210@1|root,COG3210@2|Bacteria,1RBJV@1224|Proteobacteria,2U6VU@28211|Alphaproteobacteria,4BCVQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	Hint domain	-	-	-	-	-	-	-	-	-	-	-	-	Hint_2
TLS2_k127_2937851_6	670307.HYPDE_38138	6.562e-79	276.0	COG1566@1|root,COG1566@2|Bacteria,1R7IY@1224|Proteobacteria,2VFKS@28211|Alphaproteobacteria,3N8CQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	HlyD membrane-fusion protein of T1SS	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
TLS2_k127_2937851_5	1267005.KB911265_gene3641	1.485e-86	310.0	COG1136@1|root,COG1136@2|Bacteria,1QT8W@1224|Proteobacteria,2VF20@28211|Alphaproteobacteria,3N7WH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_2937851_2	1267005.KB911265_gene3640	4.219e-139	455.0	COG0577@1|root,COG0577@2|Bacteria,1MVSU@1224|Proteobacteria,2TUN8@28211|Alphaproteobacteria,3N7KA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_2937851_8	717785.HYPMC_4199	1.001e-33	137.0	COG4731@1|root,COG4731@2|Bacteria,1N7E7@1224|Proteobacteria,2UHSI@28211|Alphaproteobacteria,3N9CY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
TLS2_k127_2937851_1	1287116.X734_12695	2.09e-175	565.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TQWP@28211|Alphaproteobacteria,43I3U@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Gamma-glutamyltranspeptidase	ggt1	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_2937851_10	745310.G432_06365	3.545e-21	99.0	COG1254@1|root,COG1254@2|Bacteria,1PU46@1224|Proteobacteria,2UF7Z@28211|Alphaproteobacteria,2K720@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the acylphosphatase family	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
TLS2_k127_2937851_4	536019.Mesop_4058	3.217e-89	303.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,43H2H@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_2937851_7	426117.M446_2315	8.656e-72	246.0	COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,2U7FW@28211|Alphaproteobacteria,1JUGU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS2_k127_2937851_3	1267005.KB911258_gene339	3.039e-118	385.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2TSKN@28211|Alphaproteobacteria,3N6JV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
TLS2_k127_2937851_9	1267005.KB911258_gene340	3.176e-32	141.0	COG1324@1|root,COG1324@2|Bacteria,1PU74@1224|Proteobacteria,2VCHK@28211|Alphaproteobacteria,3N8WT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
TLS2_k127_2937851_0	1297863.APJF01000027_gene2333	2.089e-183	576.0	COG1951@1|root,COG1951@2|Bacteria,1MW8J@1224|Proteobacteria,2U0X2@28211|Alphaproteobacteria,3JX4F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Fumarate hydratase (Fumerase)	ttdA	-	4.2.1.2,4.2.1.32	ko:K01677,ko:K03779	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
TLS2_k127_2942248_1	272630.MexAM1_META1p3440	4.938e-223	707.0	COG4547@1|root,COG4547@2|Bacteria,1MX11@1224|Proteobacteria,2TS4N@28211|Alphaproteobacteria,1JRD8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	SMART von Willebrand factor type A	cobT	-	6.6.1.2	ko:K09883	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobT,CobT_C
TLS2_k127_2942248_3	717785.HYPMC_4413	1.061e-191	602.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2TS1Z@28211|Alphaproteobacteria,3N62H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Cobaltochelatase CobS subunit N terminal	cobS	-	6.6.1.2	ko:K09882	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	AAA_5,CbbQ_C,CobS_N
TLS2_k127_2942248_11	1267005.KB911257_gene690	2.325e-67	236.0	COG0484@1|root,COG0484@2|Bacteria,1QU4R@1224|Proteobacteria,2TVZG@28211|Alphaproteobacteria,3N6VE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	heat shock protein DnaJ	dnaJ2	-	-	-	-	-	-	-	-	-	-	-	DnaJ
TLS2_k127_2942248_7	266835.14023487	3.442e-106	350.0	COG0664@1|root,COG0664@2|Bacteria,1RA0S@1224|Proteobacteria,2U65I@28211|Alphaproteobacteria,43JSY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	PFAM Bacterial regulatory proteins, crp family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_2942248_14	1267005.KB911257_gene691	6.862e-40	150.0	COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2UF6U@28211|Alphaproteobacteria,3N7CI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Belongs to the BolA IbaG family	bolA	GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:0097428,GO:0106035,GO:1901564	-	ko:K05527,ko:K22066	-	-	-	-	ko00000,ko03000,ko03029	-	-	-	BolA
TLS2_k127_2942248_5	709797.CSIRO_3272	1.454e-159	511.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TSQ3@28211|Alphaproteobacteria,3JSXI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Putative serine dehydratase domain	MA20_27460	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
TLS2_k127_2942248_0	1267005.KB911256_gene1652	5.958e-253	793.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,3N84S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	acyl-CoA dehydrogenase	mmgC	-	1.3.8.1,1.3.8.7	ko:K00248,ko:K00249,ko:K20035	ko00071,ko00280,ko00410,ko00640,ko00650,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map00920,map01100,map01110,map01120,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R11130	RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246,RC03363	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
TLS2_k127_2942248_6	1267005.KB911256_gene1651	3.307e-114	377.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2TRIM@28211|Alphaproteobacteria,3N622@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua5	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
TLS2_k127_2942248_12	1380394.JADL01000009_gene3408	4.007e-62	220.0	COG4032@1|root,COG4032@2|Bacteria,1P0HU@1224|Proteobacteria,2TRJ2@28211|Alphaproteobacteria,2JS9A@204441|Rhodospirillales	204441|Rhodospirillales	S	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_N
TLS2_k127_2942248_10	1380394.JADL01000009_gene3409	1.782e-80	273.0	COG0028@1|root,COG0028@2|Bacteria,1R6QP@1224|Proteobacteria,2TXAJ@28211|Alphaproteobacteria,2JSEG@204441|Rhodospirillales	204441|Rhodospirillales	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
TLS2_k127_2942248_9	1096546.WYO_2123	3.149e-84	287.0	COG2518@1|root,COG2518@2|Bacteria,1RAIE@1224|Proteobacteria,2U6D7@28211|Alphaproteobacteria,1JV1T@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	PFAM protein-L-isoaspartate(D-aspartate) O-methyltransferase	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
TLS2_k127_2942248_13	717785.HYPMC_4890	1.319e-53	200.0	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,2U7GI@28211|Alphaproteobacteria,3N6YV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
TLS2_k127_2942248_4	1095769.CAHF01000006_gene1956	9.628e-169	538.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,475Y7@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS2_k127_2942248_8	670307.HYPDE_41708	5.183e-105	346.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2TRIK@28211|Alphaproteobacteria,3N68J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
TLS2_k127_2942248_2	1038858.AXBA01000009_gene623	1.562e-216	675.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2TRB4@28211|Alphaproteobacteria,3EYP5@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
TLS2_k127_2977974_9	864073.HFRIS_000440	7.054e-62	219.0	COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,2VR1V@28216|Betaproteobacteria,47428@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_C_3,GST_N,GST_N_3
TLS2_k127_2977974_0	1037409.BJ6T_25830	1.473e-267	833.0	COG2303@1|root,COG2303@2|Bacteria,1N0NP@1224|Proteobacteria,2TQSK@28211|Alphaproteobacteria,3JVQR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	GMC oxidoreductase	MA20_00585	-	1.1.3.47	ko:K16873	ko00365,ko01120,map00365,map01120	-	R10212,R10216,R10858	RC00075,RC03291	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_2977974_6	1207063.P24_06686	9.428e-87	302.0	COG1011@1|root,COG1011@2|Bacteria,1MU1H@1224|Proteobacteria,2TQVC@28211|Alphaproteobacteria,2JRRZ@204441|Rhodospirillales	204441|Rhodospirillales	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase
TLS2_k127_2977974_1	1380394.JADL01000011_gene3905	3.892e-245	771.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2JPPV@204441|Rhodospirillales	204441|Rhodospirillales	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_2977974_2	279714.FuraDRAFT_0648	4.856e-206	652.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,2KPGM@206351|Neisseriales	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_2977974_8	1317124.DW2_07498	1.309e-73	251.0	COG2514@1|root,COG2514@2|Bacteria,1RC4S@1224|Proteobacteria,2TTYI@28211|Alphaproteobacteria,2XNSB@285107|Thioclava	28211|Alphaproteobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	catE	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
TLS2_k127_2977974_10	1120792.JAFV01000001_gene2540	2.755e-40	155.0	COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,2U9G4@28211|Alphaproteobacteria,36YK1@31993|Methylocystaceae	28211|Alphaproteobacteria	P	Ferric uptake regulator family	MA20_23250	-	-	ko:K09823	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	FUR
TLS2_k127_2977974_4	1267005.KB911255_gene2455	3.053e-111	369.0	COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,2TQUI@28211|Alphaproteobacteria,3N6PS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system	znuC	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
TLS2_k127_2977974_3	717785.HYPMC_0636	2.61e-139	457.0	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,2TS4Z@28211|Alphaproteobacteria,3N994@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	MatE	matE	-	-	-	-	-	-	-	-	-	-	-	MatE
TLS2_k127_2977974_7	582899.Hden_2727	4.937e-83	290.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,2TRZM@28211|Alphaproteobacteria,3N6PM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
TLS2_k127_2977974_5	266264.Rmet_0809	2.447e-88	294.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2VK17@28216|Betaproteobacteria,1K1YW@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_3014683_6	1187851.A33M_1345	9.447e-72	248.0	COG2442@1|root,COG2442@2|Bacteria,1REK1@1224|Proteobacteria,2UAYD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3014683_8	1079460.ATTQ01000006_gene3394	5.557e-54	193.0	COG5649@1|root,COG5649@2|Bacteria,1RGY3@1224|Proteobacteria,2U9AG@28211|Alphaproteobacteria,4BF17@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS2_k127_3014683_2	1122132.AQYH01000005_gene522	7.979e-171	543.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,4B9J9@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_3014683_0	1267005.KB911255_gene2599	5.777e-310	960.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria,3N6KP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TLS2_k127_3014683_9	1267005.KB911255_gene2598	8.353e-48	182.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2U5V2@28211|Alphaproteobacteria,3N73N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS2_k127_3014683_3	1267005.KB911255_gene2597	5.16e-166	527.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2TRUF@28211|Alphaproteobacteria,3N69P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
TLS2_k127_3014683_4	1267005.KB911263_gene1326	2.352e-159	506.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2TRHR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the pirin family	MA20_23765	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
TLS2_k127_3014683_5	582899.Hden_0954	3.879e-153	495.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,3N63V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470,ko:K21572	-	-	-	-	ko00000,ko01002,ko01011,ko02000	8.A.46.1,8.A.46.3	-	-	PG_binding_1,YkuD
TLS2_k127_3014683_1	670307.HYPDE_31643	3.301e-198	625.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TUX3@28211|Alphaproteobacteria,3N645@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_3014683_11	391624.OIHEL45_11188	3.286e-09	67.0	COG1873@1|root,COG1873@2|Bacteria,1N6X0@1224|Proteobacteria	1224|Proteobacteria	S	PFAM PRC-barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PRC
TLS2_k127_3014683_7	69279.BG36_24175	2.524e-60	213.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria,43JUF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS2_k127_3014683_10	582899.Hden_2363	2.372e-14	81.0	COG2982@1|root,COG2982@2|Bacteria,1QWQT@1224|Proteobacteria,2TX2D@28211|Alphaproteobacteria,3N6W2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
TLS2_k127_3032271_0	1500306.JQLA01000014_gene1935	1.028e-189	595.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2TQXW@28211|Alphaproteobacteria,4B81D@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	PHB de-polymerase C-terminus	MA20_01245	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	PHB_depo_C
TLS2_k127_3032271_2	649831.L083_2884	4.443e-37	154.0	COG1028@1|root,COG1028@2|Bacteria,2GM7N@201174|Actinobacteria	201174|Actinobacteria	IQ	dehydrogenase	-	-	1.3.1.33	ko:K00218	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03845,R06286	RC01008	ko00000,ko00001,ko01000	-	-	-	adh_short
TLS2_k127_3032271_5	331869.BAL199_21349	6.681e-05	45.0	COG1961@1|root,COG1961@2|Bacteria,1PWCY@1224|Proteobacteria,2TVME@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_3032271_3	1354722.JQLS01000008_gene931	4.831e-31	124.0	COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,2UCXT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM DoxX family protein	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
TLS2_k127_3032271_4	661478.OP10G_2719	3.978e-06	51.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
TLS2_k127_3032271_1	1121861.KB899950_gene2354	1.896e-161	521.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JV4N@204441|Rhodospirillales	204441|Rhodospirillales	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS2_k127_3094472_3	1429916.X566_13620	2.795e-152	486.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2TT14@28211|Alphaproteobacteria,3JR2J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	MA20_03550	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_3094472_2	1121106.JQKB01000023_gene3575	1.316e-164	522.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TUAN@28211|Alphaproteobacteria,2JQIU@204441|Rhodospirillales	204441|Rhodospirillales	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_3094472_0	1121106.JQKB01000023_gene3576	1.183e-216	685.0	COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2TTUB@28211|Alphaproteobacteria,2JRAR@204441|Rhodospirillales	204441|Rhodospirillales	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
TLS2_k127_3094472_1	1121106.JQKB01000023_gene3577	1.582e-185	585.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,2JQRA@204441|Rhodospirillales	204441|Rhodospirillales	E	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
TLS2_k127_313635_4	1287116.X734_16235	1.035e-32	129.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2U401@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
TLS2_k127_313635_2	670307.HYPDE_24148	9.731e-49	187.0	COG5010@1|root,COG5010@2|Bacteria,1MVTK@1224|Proteobacteria,2TVBA@28211|Alphaproteobacteria,3N776@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Tetratricopeptide repeat	MA20_18455	-	-	-	-	-	-	-	-	-	-	-	TPR_10,TPR_12,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
TLS2_k127_313635_0	670307.HYPDE_41823	2.543e-113	371.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2TRWR@28211|Alphaproteobacteria,3N6PY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS2_k127_313635_5	1197906.CAJQ02000053_gene4262	2.756e-10	63.0	2EJ3S@1|root,33CV1@2|Bacteria,1N8ZT@1224|Proteobacteria,2UFYU@28211|Alphaproteobacteria,3K0VR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_313635_3	78245.Xaut_0298	3.227e-47	178.0	COG3193@1|root,COG3193@2|Bacteria,1N08N@1224|Proteobacteria,2U5ES@28211|Alphaproteobacteria,3EZP8@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Haem-degrading	MA20_43165	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
TLS2_k127_313635_1	864069.MicloDRAFT_00015560	1.179e-104	349.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,1JSW8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_3173006_9	33876.JNXY01000028_gene3356	1.529e-92	317.0	COG2303@1|root,COG4757@1|root,COG2303@2|Bacteria,COG4757@2|Bacteria,2GNHC@201174|Actinobacteria,4DC50@85008|Micromonosporales	201174|Actinobacteria	E	GMC oxidoreductase	-	-	1.1.1.400	ko:K20927,ko:K21166	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_3173006_7	257310.BB4720	7.726e-107	355.0	COG0329@1|root,COG0329@2|Bacteria,1MWV5@1224|Proteobacteria,2VMFS@28216|Betaproteobacteria,3T49Q@506|Alcaligenaceae	28216|Betaproteobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_3173006_13	570967.JMLV01000007_gene937	1.125e-43	167.0	COG3678@1|root,COG3678@2|Bacteria,1MZKK@1224|Proteobacteria,2UE6S@28211|Alphaproteobacteria,2JUK8@204441|Rhodospirillales	204441|Rhodospirillales	NPTU	ATP-independent chaperone mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3173006_10	231434.JQJH01000009_gene1101	6.346e-56	200.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2U94H@28211|Alphaproteobacteria,3NB8Q@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Competence-damaged protein	cinA	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
TLS2_k127_3173006_11	1410620.SHLA_1c002170	8.615e-46	178.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2U7D8@28211|Alphaproteobacteria,4BE29@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	oligoketide cyclase lipid transport protein	pasT	-	-	ko:K18588	-	-	-	-	ko00000	-	-	-	Polyketide_cyc
TLS2_k127_3173006_1	1333998.M2A_0989	7.911e-164	519.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2TRP3@28211|Alphaproteobacteria,4BPK8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
TLS2_k127_3173006_14	1502851.FG93_06187	6.615e-17	83.0	COG2261@1|root,COG2261@2|Bacteria,1N6QR@1224|Proteobacteria,2UFTV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS2_k127_3173006_12	1229204.AMYY01000014_gene2011	3.396e-45	183.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRJ1@28211|Alphaproteobacteria,4BRC8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	MA20_32310	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
TLS2_k127_3173006_2	402626.Rpic_1128	8.804e-162	525.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,2VH3U@28216|Betaproteobacteria,1K1TG@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_3173006_5	1267005.KB911264_gene3201	2.826e-134	443.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2TRCS@28211|Alphaproteobacteria,3N6MC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
TLS2_k127_3173006_4	670307.HYPDE_25008	3.174e-159	512.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2TT5T@28211|Alphaproteobacteria,3N63Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008460,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_3173006_6	1267005.KB911255_gene2890	9.275e-122	399.0	COG1092@1|root,COG1092@2|Bacteria,1QSD4@1224|Proteobacteria,2TUFT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the methyltransferase superfamily	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95,Methyltrans_SAM
TLS2_k127_3173006_8	1267005.KB911255_gene2891	1.11e-101	340.0	COG0566@1|root,COG0566@2|Bacteria,1MWBE@1224|Proteobacteria,2TT4Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS2_k127_3173006_15	670307.HYPDE_33868	3.926e-05	48.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,3N68D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_3173006_0	1267005.KB911256_gene1970	1.586e-288	898.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,2TRPY@28211|Alphaproteobacteria,3N65U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	oligoendopeptidase	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
TLS2_k127_3173006_3	582899.Hden_2636	2.366e-160	509.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3N6KQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Sigma-54 interaction domain	tacA	GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat
TLS2_k127_3183434_12	883080.HMPREF9697_02027	2.268e-09	61.0	COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,2TUNP@28211|Alphaproteobacteria,3JX6N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TLS2_k127_3183434_8	1038859.AXAU01000001_gene2606	4.594e-51	184.0	COG0346@1|root,COG0346@2|Bacteria,1RB65@1224|Proteobacteria,2U7DP@28211|Alphaproteobacteria,3JYA1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	MA20_35640	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
TLS2_k127_3183434_10	1267005.KB911259_gene3857	4.712e-32	136.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,2UBTC@28211|Alphaproteobacteria,3N7AX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
TLS2_k127_3183434_6	1187851.A33M_2445	2.073e-59	219.0	COG0494@1|root,COG0494@2|Bacteria,1N8EV@1224|Proteobacteria,2TTNV@28211|Alphaproteobacteria,3FDAB@34008|Rhodovulum	28211|Alphaproteobacteria	L	NUDIX domain	MA20_36340	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_3183434_9	1267005.KB911260_gene3576	1.827e-48	180.0	COG5349@1|root,COG5349@2|Bacteria,1MZDD@1224|Proteobacteria,2UCM4@28211|Alphaproteobacteria,3N74I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
TLS2_k127_3183434_1	582899.Hden_0630	1.642e-285	896.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2TRC1@28211|Alphaproteobacteria,3N6K7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
TLS2_k127_3183434_0	648757.Rvan_2868	0.0	1129.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,3N651@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
TLS2_k127_3183434_4	1267005.KB911256_gene2043	1.658e-131	431.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2TRQE@28211|Alphaproteobacteria,3N6BY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
TLS2_k127_3183434_7	652103.Rpdx1_2305	5.403e-58	220.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2U7BZ@28211|Alphaproteobacteria,3JRDJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
TLS2_k127_3183434_2	670307.HYPDE_35178	1.795e-205	662.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,2TSTM@28211|Alphaproteobacteria,3N6DW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Amidohydrolase family	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS2_k127_3183434_3	582899.Hden_0636	7.452e-161	515.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2TRHP@28211|Alphaproteobacteria,3N6KC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_3183434_5	1510531.JQJJ01000012_gene1601	9.369e-60	214.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2TS3F@28211|Alphaproteobacteria,3JRDV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
TLS2_k127_3183434_11	1122614.JHZF01000013_gene3061	4.248e-30	122.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,2PCSI@252301|Oceanicola	28211|Alphaproteobacteria	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_3208440_10	232346.JHQL01000003_gene195	1.805e-49	182.0	COG2738@1|root,COG2738@2|Bacteria,1RDJH@1224|Proteobacteria,1S4QY@1236|Gammaproteobacteria,1XK02@135619|Oceanospirillales	135619|Oceanospirillales	S	Peptidase membrane zinc metallopeptidase	-	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
TLS2_k127_3208440_9	335659.S23_42420	8.046e-60	212.0	COG0262@1|root,COG0262@2|Bacteria,1RH02@1224|Proteobacteria,2UCTW@28211|Alphaproteobacteria,3K43A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_3208440_6	526225.Gobs_3683	8.364e-106	355.0	COG1052@1|root,COG1052@2|Bacteria,2I2IC@201174|Actinobacteria,4ETVD@85013|Frankiales	201174|Actinobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	serA2	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_3208440_3	1205680.CAKO01000002_gene2788	2.766e-185	593.0	COG1058@1|root,COG1058@2|Bacteria,1QUB2@1224|Proteobacteria	1224|Proteobacteria	S	Belongs to the CinA family	yfaY	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
TLS2_k127_3208440_8	717785.HYPMC_2679	8.834e-80	288.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2TUNI@28211|Alphaproteobacteria,3N6XP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	DM	Lysin motif	nlpD	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
TLS2_k127_3208440_0	1411123.JQNH01000001_gene2408	1.778e-232	725.0	COG1488@1|root,COG1488@2|Bacteria,1MV8U@1224|Proteobacteria,2TREY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
TLS2_k127_3208440_7	172088.AUGA01000001_gene6416	7.236e-80	283.0	COG2301@1|root,COG2301@2|Bacteria,1QGFZ@1224|Proteobacteria,2U37X@28211|Alphaproteobacteria,3JU7S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_3208440_11	670292.JH26_01340	4.05e-37	145.0	COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,2UCUT@28211|Alphaproteobacteria,1JUX4@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM cytochrome c class I	cycA	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
TLS2_k127_3208440_5	991905.SL003B_3478	2.645e-109	363.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria,4BQ4Y@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	LysR substrate binding domain	ttdR	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_3208440_1	1267005.KB911255_gene2627	5.266e-227	713.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSG6@28211|Alphaproteobacteria,3N7KG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	glcD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_3208440_4	1267005.KB911255_gene2628	2.275e-131	434.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2TRA7@28211|Alphaproteobacteria,3N7K6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	FAD linked oxidase	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_3208440_2	717785.HYPMC_3815	1.86e-204	644.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,3N890@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cysteine-rich domain	glcF	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7
TLS2_k127_3271310_0	1125973.JNLC01000001_gene46	0.0	1337.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,3JUU3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	B12 binding domain	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TLS2_k127_3271310_6	1267005.KB911256_gene2029	1.153e-27	118.0	COG2916@1|root,COG2916@2|Bacteria	2|Bacteria	S	protein dimerization activity	hvrA	-	-	ko:K03746	-	-	-	-	ko00000,ko03036,ko03400	-	-	-	Histone_HNS
TLS2_k127_3271310_4	582899.Hden_2369	9.151e-32	127.0	COG5425@1|root,COG5425@2|Bacteria,1N08I@1224|Proteobacteria,2UBVR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	PFAM Usg family protein	MA20_32470	-	-	-	-	-	-	-	-	-	-	-	Usg
TLS2_k127_3271310_7	1267005.KB911264_gene3199	1.782e-24	113.0	COG0174@1|root,339XI@2|Bacteria	2|Bacteria	E	glutamate-ammonia ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
TLS2_k127_3271310_5	1231190.NA8A_13450	3.243e-29	122.0	2DPP7@1|root,332UY@2|Bacteria,1N75H@1224|Proteobacteria,2UFXZ@28211|Alphaproteobacteria,43KVV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
TLS2_k127_3271310_2	717785.HYPMC_4809	3.822e-77	264.0	COG3897@1|root,COG3897@2|Bacteria,1N9VC@1224|Proteobacteria,2TV6N@28211|Alphaproteobacteria,3N714@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Ribosomal protein L11 methyltransferase (PrmA)	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010565,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018023,GO:0018193,GO:0018205,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031974,GO:0031998,GO:0031999,GO:0032259,GO:0036211,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043414,GO:0043467,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045833,GO:0045922,GO:0046320,GO:0046322,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050994,GO:0050995,GO:0051341,GO:0051354,GO:0062012,GO:0062014,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1904732,GO:1904733,GO:1904735,GO:1904736	-	-	-	-	-	-	-	-	-	-	PrmA
TLS2_k127_3271310_1	1267005.KB911255_gene2581	7.572e-102	351.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2TR2V@28211|Alphaproteobacteria,3N6PT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
TLS2_k127_3271310_3	717785.HYPMC_4389	1.054e-33	142.0	2E4J8@1|root,33KIF@2|Bacteria,1NI41@1224|Proteobacteria,2UYH0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2541
TLS2_k127_3280198_13	319003.Bra1253DRAFT_04194	1.513e-23	106.0	COG1514@1|root,COG1514@2|Bacteria,1RF2Z@1224|Proteobacteria,2U8SN@28211|Alphaproteobacteria,3JZ35@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
TLS2_k127_3280198_12	717785.HYPMC_1148	9.913e-30	122.0	COG0790@1|root,COG0790@2|Bacteria,1N8SR@1224|Proteobacteria,2UFFQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0790 FOG TPR repeat, SEL1 subfamily	MA20_36515	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
TLS2_k127_3280198_3	1267005.KB911255_gene2496	9.395e-134	434.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria,3N6AD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	GM	NmrA-like family	MA20_24380	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind
TLS2_k127_3280198_11	582899.Hden_3209	5.975e-37	141.0	COG0762@1|root,COG0762@2|Bacteria,1N73Q@1224|Proteobacteria,2UFZR@28211|Alphaproteobacteria,3N7BT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	YGGT family	MA20_25225	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
TLS2_k127_3280198_14	1336243.JAEA01000012_gene3009	3.994e-18	92.0	COG1872@1|root,COG1872@2|Bacteria,1N6V2@1224|Proteobacteria,2UF67@28211|Alphaproteobacteria,1JVYQ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0235 family	MA20_25230	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
TLS2_k127_3280198_4	1411123.JQNH01000001_gene2750	1.519e-124	406.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
TLS2_k127_3280198_10	1333856.L686_06545	1.934e-62	217.0	COG0346@1|root,COG0346@2|Bacteria,1RH4D@1224|Proteobacteria,1S6J6@1236|Gammaproteobacteria,1Z2TB@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_3280198_8	1267005.KB911256_gene1522	3.484e-78	286.0	COG4782@1|root,COG4782@2|Bacteria,1MVAD@1224|Proteobacteria,2TTCR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Protein conserved in bacteria	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	DUF900,Sel1
TLS2_k127_3280198_7	864069.MicloDRAFT_00040700	4.417e-93	317.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TRA8@28211|Alphaproteobacteria,1JU7Y@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	coxM	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_3280198_9	991905.SL003B_1047	5.613e-64	225.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U5BM@28211|Alphaproteobacteria,4BQ74@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_3280198_15	414684.RC1_3402	8.98e-15	86.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,2JQVJ@204441|Rhodospirillales	204441|Rhodospirillales	T	transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg
TLS2_k127_3280198_0	639283.Snov_0742	1.385e-310	976.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria,3EYZF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Domain of unknown function (DUF3458_C) ARM repeats	pepN	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
TLS2_k127_3280198_5	526227.Mesil_3006	7.507e-113	370.0	COG1024@1|root,COG1024@2|Bacteria,1WJ7Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_3280198_6	1100721.ALKO01000017_gene1635	9.187e-109	357.0	COG1028@1|root,COG1028@2|Bacteria,1QWBB@1224|Proteobacteria,2W24M@28216|Betaproteobacteria,4AJ28@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_3280198_1	883080.HMPREF9697_01875	7.438e-199	645.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1042 Acyl-CoA synthetase (NDP forming)	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
TLS2_k127_3280198_2	1244869.H261_01227	1.194e-136	448.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TSGF@28211|Alphaproteobacteria,2JPV5@204441|Rhodospirillales	204441|Rhodospirillales	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	paaH	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_328255_1	670307.HYPDE_37173	9.7e-175	566.0	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,2U1SX@28211|Alphaproteobacteria,3N7RR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	ABC-type uncharacterized transport system	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_transp_aux
TLS2_k127_328255_3	717785.HYPMC_0678	2.452e-107	359.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,2TUXR@28211|Alphaproteobacteria,3N8C2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
TLS2_k127_328255_2	1267005.KB911259_gene3761	6.027e-129	421.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2U2JX@28211|Alphaproteobacteria,3N7IY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_328255_6	1267005.KB911257_gene727	1.362e-58	212.0	COG5352@1|root,COG5352@2|Bacteria,1RHI6@1224|Proteobacteria,2TS7F@28211|Alphaproteobacteria,3N758@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	GcrA cell cycle regulator	gcrA	-	-	ko:K13583	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	GcrA
TLS2_k127_328255_0	472175.EL18_01185	4.502e-224	704.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria,43HMX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS2_k127_328255_4	384765.SIAM614_04935	4.623e-59	215.0	COG0398@1|root,COG0398@2|Bacteria,1MVF3@1224|Proteobacteria,2U6DE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	SNARE associated golgi protein	merA_1	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_328255_5	1282876.BAOK01000001_gene3333	5.616e-59	209.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TU0K@28211|Alphaproteobacteria,4BPW3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_3293715_12	1469245.JFBG01000057_gene2376	1.824e-62	222.0	COG4665@1|root,COG4665@2|Bacteria,1RG47@1224|Proteobacteria,1S3PZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	TRAP-type mannitol chloroaromatic compound transport system small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_3293715_0	1469245.JFBG01000057_gene2375	3.234e-214	676.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1WWHM@135613|Chromatiales	1236|Gammaproteobacteria	Q	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_3293715_1	1038859.AXAU01000008_gene2082	4.008e-168	534.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria,3JYMW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_3293715_2	1038859.AXAU01000008_gene2082	1.86e-164	524.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria,3JYMW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_3293715_15	1227739.Hsw_0843	1.839e-29	122.0	COG0454@1|root,COG0456@2|Bacteria,4NP44@976|Bacteroidetes,47VE2@768503|Cytophagia	976|Bacteroidetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
TLS2_k127_3293715_4	398525.KB900701_gene5496	4.477e-150	478.0	COG0596@1|root,COG0596@2|Bacteria,1NJ2B@1224|Proteobacteria,2TR54@28211|Alphaproteobacteria,3JQWT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_3293715_10	1267005.KB911255_gene2476	6.46e-77	281.0	28JTG@1|root,2Z7PY@2|Bacteria,1QVNY@1224|Proteobacteria,2U7ED@28211|Alphaproteobacteria,3N6VP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2793)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2793
TLS2_k127_3293715_18	1156935.QWE_05793	4.944e-16	92.0	2DE5J@1|root,2ZKKF@2|Bacteria,1PEK2@1224|Proteobacteria,2V8UU@28211|Alphaproteobacteria,4BK2W@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3293715_17	1122132.AQYH01000015_gene2282	3.74e-16	93.0	2DSRK@1|root,33H6U@2|Bacteria,1P21N@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3293715_16	1348338.ADILRU_1048	9.229e-23	113.0	COG4733@1|root,COG4733@2|Bacteria,2I6WJ@201174|Actinobacteria,4FP8V@85023|Microbacteriaceae	201174|Actinobacteria	D	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
TLS2_k127_3293715_14	1354722.JQLS01000008_gene1692	2.113e-30	132.0	2EIWD@1|root,33CMP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3293715_5	1449351.RISW2_03545	2.078e-141	467.0	COG4146@1|root,COG4146@2|Bacteria,1MXWV@1224|Proteobacteria,2TUK8@28211|Alphaproteobacteria,4KK29@93682|Roseivivax	28211|Alphaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
TLS2_k127_3293715_6	335659.S23_39070	3.208e-134	435.0	COG0491@1|root,COG0491@2|Bacteria,1MY6G@1224|Proteobacteria,2TTBX@28211|Alphaproteobacteria,3JTGB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	MA20_30545	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_3293715_9	1211115.ALIQ01000238_gene3256	4.042e-96	325.0	COG2242@1|root,COG2242@2|Bacteria,1R0I9@1224|Proteobacteria,2TZR6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_3293715_3	331869.BAL199_19041	1.888e-154	494.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2TQYA@28211|Alphaproteobacteria,4BPIP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the AB hydrolase superfamily. MetX family	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_3293715_11	1040989.AWZU01000049_gene944	3.81e-70	241.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U7EJ@28211|Alphaproteobacteria,3JYIC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	MA20_19600	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
TLS2_k127_3293715_13	1266908.AQPB01000055_gene1950	2.829e-45	168.0	COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,1S77V@1236|Gammaproteobacteria,1WYAI@135613|Chromatiales	135613|Chromatiales	S	PFAM Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CYTH
TLS2_k127_3293715_7	113395.AXAI01000031_gene620	2.146e-119	391.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2TSUS@28211|Alphaproteobacteria,3JV0U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	LysR family	oxyR	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
TLS2_k127_3293715_8	929562.Emtol_3375	3.694e-114	372.0	COG0376@1|root,COG0376@2|Bacteria,4NG30@976|Bacteroidetes,47KR2@768503|Cytophagia	976|Bacteroidetes	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
TLS2_k127_3331013_7	1267005.KB911259_gene3995	2.632e-42	161.0	COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,2UBYD@28211|Alphaproteobacteria,3N8XI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	phosphohistidine phosphatase, SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
TLS2_k127_3331013_4	331869.BAL199_17848	7.312e-117	386.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2TUUN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate	-	-	4.1.1.3	ko:K01003	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
TLS2_k127_3331013_3	1380394.JADL01000011_gene4018	2.544e-125	411.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,2JV65@204441|Rhodospirillales	204441|Rhodospirillales	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
TLS2_k127_3331013_2	709032.Sulku_2336	1.224e-148	488.0	COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,42MI1@68525|delta/epsilon subdivisions,2YMPQ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	I	Sulfatase	eptA	-	2.7.8.43	ko:K03760	ko01503,map01503	M00722	R11555,R11556,R11557	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DUF1705,Sulfatase
TLS2_k127_3331013_6	313612.L8106_15460	3.027e-44	170.0	COG4627@1|root,COG4627@2|Bacteria,1G5IW@1117|Cyanobacteria,1HBTY@1150|Oscillatoriales	1117|Cyanobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_3331013_0	1267005.KB911258_gene490	0.0	1208.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria,3N61N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_3331013_1	1211115.ALIQ01000139_gene1303	8.41e-170	542.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2TRN1@28211|Alphaproteobacteria,3NA8N@45404|Beijerinckiaceae	28211|Alphaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038,ko:K21977	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TLS2_k127_3331013_5	633149.Bresu_0226	3.347e-56	201.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,2KGMZ@204458|Caulobacterales	204458|Caulobacterales	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
TLS2_k127_333108_8	1380355.JNIJ01000018_gene4566	6.441e-38	143.0	COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,2TRK0@28211|Alphaproteobacteria,3JRNN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Mo-co oxidoreductase dimerisation domain	-	-	1.8.3.1	ko:K00387	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00533	RC00168	ko00000,ko00001,ko01000	-	-	-	Mo-co_dimer,Oxidored_molyb
TLS2_k127_333108_9	1411123.JQNH01000001_gene3147	4.192e-31	127.0	COG3474@1|root,COG3474@2|Bacteria,1N6WA@1224|Proteobacteria,2UHTC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_333108_2	670307.HYPDE_35373	4.515e-134	439.0	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2TS4G@28211|Alphaproteobacteria,3N6M8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
TLS2_k127_333108_0	1267005.KB911256_gene1987	2.022e-212	665.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2TQPA@28211|Alphaproteobacteria,3N65S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TLS2_k127_333108_6	1297863.APJF01000021_gene169	7.593e-57	205.0	COG2259@1|root,COG2259@2|Bacteria,1N1VA@1224|Proteobacteria,2TVZ9@28211|Alphaproteobacteria,3JRVF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
TLS2_k127_333108_4	420324.KI912063_gene6832	9.501e-76	267.0	COG3219@1|root,COG3219@2|Bacteria,1PSSN@1224|Proteobacteria,2UVBT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2063
TLS2_k127_333108_3	1297863.APJF01000021_gene170	6.926e-116	386.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2TRZJ@28211|Alphaproteobacteria,3JR0V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
TLS2_k127_333108_10	420324.KI912063_gene6834	4.142e-30	132.0	COG5572@1|root,COG5572@2|Bacteria,1MZ6Q@1224|Proteobacteria,2UJ9X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Predicted integral membrane protein (DUF2282)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2282
TLS2_k127_333108_7	663610.JQKO01000016_gene1572	3.827e-48	179.0	COG1595@1|root,COG1595@2|Bacteria,1MVS7@1224|Proteobacteria,2UA8J@28211|Alphaproteobacteria,3NCMM@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_333108_5	420324.KI912063_gene6836	1.211e-66	237.0	COG4944@1|root,COG4944@2|Bacteria,1RD4P@1224|Proteobacteria,2U8EX@28211|Alphaproteobacteria,1JYWQ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1109)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1109
TLS2_k127_333108_1	1267005.KB911256_gene1988	1.258e-182	612.0	COG2982@1|root,COG2982@2|Bacteria,1QWQT@1224|Proteobacteria,2TX2D@28211|Alphaproteobacteria,3N6W2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
TLS2_k127_33385_5	348824.LPU83_2990	0.0005072	51.0	COG4176@1|root,COG4176@2|Bacteria,1QTTE@1224|Proteobacteria,2TS3U@28211|Alphaproteobacteria,4BAA7@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	glycine betaine transport system, permease	proW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0008150,GO:0015695,GO:0015696,GO:0015871,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K02001	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
TLS2_k127_33385_3	1037409.BJ6T_63940	9.212e-112	379.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria,3JQW2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TLS2_k127_33385_4	172088.AUGA01000037_gene3731	2.623e-84	289.0	COG0600@1|root,COG0600@2|Bacteria,1MV98@1224|Proteobacteria,2TXGN@28211|Alphaproteobacteria,3JWXK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TLS2_k127_33385_1	1040989.AWZU01000002_gene5322	4.16e-167	530.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,3JRGD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14,4.4.1.23	ko:K00549,ko:K22363	ko00270,ko00450,ko00625,ko01100,ko01110,ko01230,map00270,map00450,map00625,map01100,map01110,map01230	M00017	R04405,R09365,R11897,R11899	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
TLS2_k127_33385_0	998674.ATTE01000001_gene3189	4.2e-229	721.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,1RZ1Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_33385_2	1380394.JADL01000012_gene895	2.576e-114	372.0	COG0179@1|root,COG0179@2|Bacteria,1NM05@1224|Proteobacteria,2U0IB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Domain of unknown function (DUF2437)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
TLS2_k127_3342586_19	1267005.KB911255_gene2437	1.943e-70	248.0	COG0500@1|root,COG2226@2|Bacteria,1NA7K@1224|Proteobacteria,2TT7T@28211|Alphaproteobacteria,3N6ZM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	Methyltransferase domain	MA20_39625	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_3342586_25	1131814.JAFO01000001_gene1988	0.0007497	46.0	2FKPB@1|root,315D7@2|Bacteria,1PVF5@1224|Proteobacteria,2V6UT@28211|Alphaproteobacteria,3F25M@335928|Xanthobacteraceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3342586_6	582899.Hden_3387	1.414e-126	415.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2TRMC@28211|Alphaproteobacteria,3N6E9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
TLS2_k127_3342586_22	1121939.L861_12180	3.628e-21	104.0	2DBVG@1|root,2ZBB1@2|Bacteria,1N1MS@1224|Proteobacteria,1S9R7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3342586_23	1354722.JQLS01000008_gene3571	8.934e-14	78.0	COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,2UJK6@28211|Alphaproteobacteria,46RAU@74030|Roseovarius	28211|Alphaproteobacteria	H	COG2104 Sulfur transfer protein involved in thiamine biosynthesis	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS2_k127_3342586_8	1267005.KB911263_gene1342	7.582e-115	376.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria,3N7I4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
TLS2_k127_3342586_17	1267005.KB911263_gene1343	7.666e-74	259.0	COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,2TSXT@28211|Alphaproteobacteria,3N8J9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TLS2_k127_3342586_21	717785.HYPMC_0735	2.013e-39	159.0	COG5607@1|root,COG5607@2|Bacteria,1RH6R@1224|Proteobacteria,2U7IN@28211|Alphaproteobacteria,3N7G4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
TLS2_k127_3342586_20	1079460.ATTQ01000005_gene2137	3.826e-55	209.0	COG0477@1|root,COG2814@2|Bacteria,1R3UT@1224|Proteobacteria,2TR7Z@28211|Alphaproteobacteria,4B9I6@82115|Rhizobiaceae	28211|Alphaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_3342586_10	1267005.KB911255_gene2638	4.031e-109	359.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2TR57@28211|Alphaproteobacteria,3N64K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
TLS2_k127_3342586_3	1268622.AVS7_00899	4.093e-175	559.0	COG0015@1|root,COG0015@2|Bacteria,1MXNN@1224|Proteobacteria,2VID3@28216|Betaproteobacteria,4AAZ9@80864|Comamonadaceae	28216|Betaproteobacteria	F	PFAM fumarate lyase	-	-	4.3.2.2,5.5.1.2	ko:K01756,ko:K01857	ko00230,ko00250,ko00362,ko01100,ko01110,ko01120,ko01130,ko01220,map00230,map00250,map00362,map01100,map01110,map01120,map01130,map01220	M00048,M00049	R01083,R03307,R04559	RC00379,RC00444,RC00445,RC00902	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
TLS2_k127_3342586_13	1502851.FG93_05795	6.322e-99	331.0	COG2084@1|root,COG2084@2|Bacteria,1MUD0@1224|Proteobacteria,2TT7P@28211|Alphaproteobacteria,3JT85@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	MA20_16450	-	1.1.1.411	ko:K08319	-	-	-	-	ko00000,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_3342586_1	582899.Hden_2469	9.781e-299	934.0	COG0480@1|root,COG0480@2|Bacteria,1MU2W@1224|Proteobacteria,2TYVK@28211|Alphaproteobacteria,3N7ME@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Elongation factor G, domain IV	MA20_05220	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_3342586_18	1267005.KB911257_gene719	1.146e-72	255.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	Laminin_G_3,PKD,TIG,TPP_enzyme_M,fn3
TLS2_k127_3342586_0	1267005.KB911257_gene718	1.954e-306	962.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2TU7G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
TLS2_k127_3342586_5	1267005.KB911257_gene1090	4.426e-135	440.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2TRG1@28211|Alphaproteobacteria,3N61Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	AFG1-like ATPase	zapE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0017144,GO:0019538,GO:0019637,GO:0019646,GO:0019693,GO:0022900,GO:0022904,GO:0030163,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0035694,GO:0042773,GO:0042775,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071840,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901565,GO:1901575	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
TLS2_k127_3342586_9	1205680.CAKO01000006_gene3149	9.501e-114	372.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TSE7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	branched-chain amino acid	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_3342586_12	1205680.CAKO01000006_gene3150	3.104e-99	341.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2U1BU@28211|Alphaproteobacteria,2JW92@204441|Rhodospirillales	204441|Rhodospirillales	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_3342586_4	1205680.CAKO01000006_gene3151	2.378e-138	445.0	COG0559@1|root,COG0559@2|Bacteria,1MXGK@1224|Proteobacteria,2TVKT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	MA20_18605	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_3342586_11	1380394.JADL01000002_gene1158	6.025e-104	350.0	COG4177@1|root,COG4177@2|Bacteria,1P0DF@1224|Proteobacteria,2TUBF@28211|Alphaproteobacteria,2JUXE@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
TLS2_k127_3342586_2	1205680.CAKO01000006_gene3155	3.391e-176	561.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2UQXU@28211|Alphaproteobacteria,2JYN9@204441|Rhodospirillales	204441|Rhodospirillales	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
TLS2_k127_3342586_7	670307.HYPDE_22613	1.96e-116	391.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,3N6FG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	ppk_2	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008976,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0042802,GO:0044237	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
TLS2_k127_3342586_14	1121405.dsmv_2680	2.816e-79	272.0	COG2267@1|root,COG2267@2|Bacteria,1NK3M@1224|Proteobacteria,43BSK@68525|delta/epsilon subdivisions,2X73C@28221|Deltaproteobacteria,2MKFI@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_3342586_15	316058.RPB_4658	7.447e-78	278.0	COG0410@1|root,COG0410@2|Bacteria,1MVYI@1224|Proteobacteria,2TSRT@28211|Alphaproteobacteria,3JR1U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ABC transporter	MA20_22545	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_3342586_16	365044.Pnap_1904	1.882e-74	258.0	COG0411@1|root,COG0411@2|Bacteria,1MXHT@1224|Proteobacteria,2VKUM@28216|Betaproteobacteria,4ABGV@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_3342586_24	1366050.N234_07080	4.606e-12	71.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VK9Y@28216|Betaproteobacteria,1KFBU@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_3351272_27	1267005.KB911255_gene2531	1.528e-65	224.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2TS2T@28211|Alphaproteobacteria,3N684@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
TLS2_k127_3351272_1	717785.HYPMC_2497	1.137e-251	794.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2TRZQ@28211|Alphaproteobacteria,3N63S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	exonuclease RecJ	recJ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TLS2_k127_3351272_21	114615.BRADO5212	1.749e-106	355.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2TUQ1@28211|Alphaproteobacteria,3JRVC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_3351272_11	1267005.KB911258_gene629	7.879e-140	452.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2TRJX@28211|Alphaproteobacteria,3N7VD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
TLS2_k127_3351272_34	1122137.AQXF01000005_gene1077	8.873e-35	139.0	COG3791@1|root,COG3791@2|Bacteria,1N6S5@1224|Proteobacteria,2UG0P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS2_k127_3351272_30	391593.RCCS2_02965	5.167e-56	197.0	COG5470@1|root,COG5470@2|Bacteria,1RIH6@1224|Proteobacteria,2U9VZ@28211|Alphaproteobacteria,2P3D7@2433|Roseobacter	28211|Alphaproteobacteria	S	NIPSNAP	MA20_35555	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
TLS2_k127_3351272_31	391593.RCCS2_02960	3.472e-50	183.0	COG2329@1|root,COG2329@2|Bacteria,1RGVV@1224|Proteobacteria,2U9A3@28211|Alphaproteobacteria,2P3E8@2433|Roseobacter	28211|Alphaproteobacteria	I	enzyme involved in biosynthesis of extracellular polysaccharides	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS2_k127_3351272_25	398525.KB900701_gene2404	2.344e-68	240.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2U7C4@28211|Alphaproteobacteria,3JTPP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
TLS2_k127_3351272_10	717785.HYPMC_4170	8.196e-147	471.0	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2TS6D@28211|Alphaproteobacteria,3N76Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the pseudomonas-type ThrB family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
TLS2_k127_3351272_8	1535287.JP74_09535	5.089e-152	488.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2TRNR@28211|Alphaproteobacteria,3N6IE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
TLS2_k127_3351272_28	1267005.KB911255_gene2949	1.739e-59	218.0	2CB63@1|root,3349C@2|Bacteria,1RKRV@1224|Proteobacteria,2U0FI@28211|Alphaproteobacteria,3N7GN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3351272_7	438753.AZC_4245	1.545e-156	503.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2TRN4@28211|Alphaproteobacteria,3F0HP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TLS2_k127_3351272_32	1205680.CAKO01000038_gene1449	9.034e-45	169.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2U9BY@28211|Alphaproteobacteria,2JSV1@204441|Rhodospirillales	204441|Rhodospirillales	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
TLS2_k127_3351272_29	1411123.JQNH01000001_gene418	1.684e-57	205.0	COG1764@1|root,COG1764@2|Bacteria,1RI5C@1224|Proteobacteria,2U99X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	redox protein regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_3351272_5	1038858.AXBA01000013_gene2356	7.124e-211	666.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2TR6C@28211|Alphaproteobacteria,3F0T8@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
TLS2_k127_3351272_2	1134912.AJTV01000018_gene3264	4.971e-243	760.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2TSFF@28211|Alphaproteobacteria,36XMT@31993|Methylocystaceae	28211|Alphaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5,GDC-P
TLS2_k127_3351272_22	670307.HYPDE_24603	5.328e-96	347.0	COG0790@1|root,COG3170@1|root,COG0790@2|Bacteria,COG3170@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,3N6X8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Sel1-like repeats.	-	-	-	ko:K07126,ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	PG_binding_1,Sel1
TLS2_k127_3351272_13	1267005.KB911265_gene3628	5.377e-130	422.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,2TRIC@28211|Alphaproteobacteria,3N695@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	membrane transporter protein	MA20_19835	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_3351272_24	1267005.KB911265_gene3629	8.47e-71	264.0	2AFUA@1|root,315WQ@2|Bacteria,1NHGB@1224|Proteobacteria,2TQWW@28211|Alphaproteobacteria,3N79W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative transmembrane protein (Alph_Pro_TM)	MA20_19830	-	-	-	-	-	-	-	-	-	-	-	Alph_Pro_TM
TLS2_k127_3351272_0	1267005.KB911259_gene3813	2.363e-277	864.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,3N7VQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	poly(R)-hydroxyalkanoic acid synthase	phbC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
TLS2_k127_3351272_4	864069.MicloDRAFT_00024990	5.058e-214	671.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2TRE3@28211|Alphaproteobacteria,1JRNK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM Aminotransferase class I and II	aatC	GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_3351272_38	717785.HYPMC_1707	4.555e-10	64.0	2DGHW@1|root,2ZW1T@2|Bacteria,1P867@1224|Proteobacteria,2UWAZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3351272_6	670307.HYPDE_26118	4.702e-191	613.0	COG1752@1|root,COG1752@2|Bacteria,1PI8V@1224|Proteobacteria,2VD78@28211|Alphaproteobacteria,3N96B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
TLS2_k127_3351272_39	1298867.AUES01000046_gene4076	3.617e-09	63.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2TT42@28211|Alphaproteobacteria,3JUY5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	MA20_38050	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_3351272_18	582899.Hden_2242	8.614e-114	373.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,3N6RK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS2_k127_3351272_23	1267005.KB911256_gene1932	5.013e-80	273.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2TTIA@28211|Alphaproteobacteria,3N6RH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
TLS2_k127_3351272_16	1122963.AUHB01000003_gene3912	5.607e-122	402.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,2TSHM@28211|Alphaproteobacteria,36XNG@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Ethanolamine utilisation - propanediol utilisation	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
TLS2_k127_3351272_12	1211115.ALIQ01000182_gene1509	1.403e-137	446.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2TR2Q@28211|Alphaproteobacteria,3NAIS@45404|Beijerinckiaceae	28211|Alphaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	hndI	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3351272_14	582899.Hden_0467	1.852e-128	418.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2TQSY@28211|Alphaproteobacteria,3N6HW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Transport permease protein	yadH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_3351272_26	460265.Mnod_5136	9.328e-67	239.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2TUX7@28211|Alphaproteobacteria,1JT5Z@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	PFAM Sporulation domain protein	MA20_36170	-	-	-	-	-	-	-	-	-	-	-	SLT,SPOR
TLS2_k127_3351272_33	1472716.KBK24_0121145	1.201e-37	153.0	COG3103@1|root,COG5183@1|root,COG4991@2|Bacteria,COG5183@2|Bacteria,1N1ZX@1224|Proteobacteria,2VSMT@28216|Betaproteobacteria,1K8ZW@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Bacterial SH3 domain homologues	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3,SH3_4
TLS2_k127_3351272_20	670307.HYPDE_34133	9.263e-112	367.0	COG1381@1|root,COG1381@2|Bacteria,1MVEJ@1224|Proteobacteria,2TTYW@28211|Alphaproteobacteria,3N6R2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
TLS2_k127_3351272_37	1287116.X734_18835	1.688e-19	93.0	COG5478@1|root,COG5478@2|Bacteria,1N9N3@1224|Proteobacteria,2UG32@28211|Alphaproteobacteria,43Q4Y@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Low affinity iron permease	-	-	-	-	-	-	-	-	-	-	-	-	Iron_permease
TLS2_k127_3351272_3	631454.N177_4026	4.017e-221	696.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,1JN7Y@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	gabD	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006105,GO:0006520,GO:0006536,GO:0006538,GO:0006540,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009266,GO:0009314,GO:0009408,GO:0009416,GO:0009448,GO:0009450,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009628,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0019752,GO:0031974,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0050896,GO:0051287,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072329,GO:0072593,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_3351272_35	582899.Hden_1287	1.303e-23	102.0	28UZA@1|root,2ZUTI@2|Bacteria,1P56A@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3351272_9	1089551.KE386572_gene3276	1.079e-149	481.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TQR9@28211|Alphaproteobacteria,4BQZ5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Amino-transferase class IV	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS2_k127_3351272_17	1411123.JQNH01000001_gene3815	6.002e-117	385.0	COG4521@1|root,COG4521@2|Bacteria,1MVH2@1224|Proteobacteria,2TVXB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG4521 ABC-type taurine transport system periplasmic component	tauA	-	-	ko:K15551	ko00920,ko02010,map00920,map02010	M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.1,3.A.1.17.4	-	-	NMT1
TLS2_k127_3351272_15	1411123.JQNH01000001_gene3816	5.628e-124	408.0	COG4525@1|root,COG4525@2|Bacteria,1QTUA@1224|Proteobacteria,2TW95@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system	tauB	-	3.6.3.36	ko:K10831	ko00920,ko02010,map00920,map02010	M00435	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.17.1,3.A.1.17.4	-	-	ABC_tran
TLS2_k127_3351272_19	1411123.JQNH01000001_gene3817	1.427e-113	375.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,2TRDG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K15552	ko00920,ko02010,map00920,map02010	M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.1,3.A.1.17.4	-	-	BPD_transp_1
TLS2_k127_3370628_4	1267005.KB911260_gene3453	1.216e-60	226.0	COG2200@1|root,COG2200@2|Bacteria,1MU4F@1224|Proteobacteria,2TU9M@28211|Alphaproteobacteria,3N7EJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	MA20_05620	-	-	ko:K13593	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	EAL
TLS2_k127_3370628_2	670307.HYPDE_35888	6.321e-90	306.0	COG0647@1|root,COG0647@2|Bacteria,1MU9Y@1224|Proteobacteria,2TUH0@28211|Alphaproteobacteria,3N6SE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Haloacid dehalogenase-like hydrolase	MA20_05625	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
TLS2_k127_3370628_1	402881.Plav_2485	1.691e-140	470.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,1JNCZ@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	DEAD-like helicases superfamily	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
TLS2_k127_3370628_6	402881.Plav_2315	4.887e-42	161.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2U7DJ@28211|Alphaproteobacteria,1JP00@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Yqey-like protein	MA20_04985	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS2_k127_3370628_8	316055.RPE_1045	1.398e-37	152.0	2CBAE@1|root,32YK1@2|Bacteria,1N7NP@1224|Proteobacteria,2UH5V@28211|Alphaproteobacteria,3K1DU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3370628_7	1197906.CAJQ02000003_gene3161	4.635e-40	156.0	2CBFC@1|root,32RYI@2|Bacteria,1N0T4@1224|Proteobacteria,2UGBM@28211|Alphaproteobacteria,3K0Y5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3370628_0	1121106.JQKB01000008_gene1417	3.349e-160	519.0	COG0457@1|root,COG0457@2|Bacteria,1N01S@1224|Proteobacteria,2TSR4@28211|Alphaproteobacteria,2JQKI@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3370628_3	717785.HYPMC_0561	5.213e-69	254.0	COG2304@1|root,COG4961@1|root,COG2304@2|Bacteria,COG4961@2|Bacteria,1MWXU@1224|Proteobacteria,2TRQP@28211|Alphaproteobacteria,3N7FF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad,VWA
TLS2_k127_3370628_5	582899.Hden_2304	8.059e-44	171.0	COG2304@1|root,COG4961@1|root,COG2304@2|Bacteria,COG4961@2|Bacteria,1MWXU@1224|Proteobacteria,2TRQP@28211|Alphaproteobacteria,3N7FF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad,VWA
TLS2_k127_343554_6	1082931.KKY_2008	0.0003443	44.0	2DQNQ@1|root,337TP@2|Bacteria,1NFYG@1224|Proteobacteria,2UFD8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_343554_0	1267005.KB911255_gene2533	0.0	1059.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,3N6EZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
TLS2_k127_343554_3	1267005.KB911255_gene2460	4.304e-78	266.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2U58Z@28211|Alphaproteobacteria,3N6RM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
TLS2_k127_343554_5	401053.AciPR4_0616	2.27e-45	170.0	COG0563@1|root,COG0563@2|Bacteria	2|Bacteria	F	adenylate kinase activity	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_18,ADK,ADK_lid
TLS2_k127_343554_1	1205680.CAKO01000029_gene5115	3.319e-241	752.0	COG2141@1|root,COG2141@2|Bacteria,1R7GC@1224|Proteobacteria,2U0DW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_343554_4	595536.ADVE02000001_gene953	3.232e-72	255.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,2U279@28211|Alphaproteobacteria,36Y9T@31993|Methylocystaceae	28211|Alphaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	hycG	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
TLS2_k127_343554_2	1380350.JIAP01000010_gene5851	3.565e-82	277.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,1QUBF@1224|Proteobacteria,2TRE0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	NADH-ubiquinone oxidoreductase chain 49kDa	hycE	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
TLS2_k127_3435655_3	1121861.KB899913_gene2139	1.347e-55	202.0	COG0625@1|root,COG0625@2|Bacteria,1RD4X@1224|Proteobacteria,2U750@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the GST superfamily	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_C_3,GST_N,GST_N_3
TLS2_k127_3435655_0	1411123.JQNH01000001_gene670	0.0	1406.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits	-	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
TLS2_k127_3435655_2	864069.MicloDRAFT_00042530	6.173e-139	446.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,2TS3H@28211|Alphaproteobacteria,1JTVX@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM transferase hexapeptide repeat containing protein	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
TLS2_k127_3435655_4	582899.Hden_2119	1.56e-39	156.0	2FC42@1|root,34480@2|Bacteria,1P1IM@1224|Proteobacteria,2UVJU@28211|Alphaproteobacteria,3N8XZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3435655_1	717785.HYPMC_1405	4.513e-177	564.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,2TS8J@28211|Alphaproteobacteria,3N6T0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF559,SpoU_methylase
TLS2_k127_3435655_5	288000.BBta_6744	5.284e-28	119.0	COG0582@1|root,COG0582@2|Bacteria,1NH8M@1224|Proteobacteria,2TUHG@28211|Alphaproteobacteria,3JYRR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_347889_7	648757.Rvan_0606	5.774e-26	109.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2UF3C@28211|Alphaproteobacteria,3N7C7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	tusA	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
TLS2_k127_347889_1	1267005.KB911258_gene88	3.724e-215	674.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria,3N63R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	MgsA AAA+ ATPase C terminal	rarA	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
TLS2_k127_347889_4	1411123.JQNH01000001_gene2404	4.673e-147	483.0	COG0405@1|root,COG0405@2|Bacteria,1MXXD@1224|Proteobacteria,2TSB2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Gamma-glutamyltransferase	MA20_09815	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_347889_6	640081.Dsui_3019	3.793e-72	252.0	COG2267@1|root,COG2267@2|Bacteria,1Q6AF@1224|Proteobacteria,2VJQ3@28216|Betaproteobacteria,2KWPA@206389|Rhodocyclales	206389|Rhodocyclales	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS2_k127_347889_0	1502851.FG93_04203	1.181e-228	735.0	COG4485@1|root,COG4485@2|Bacteria,1NBM0@1224|Proteobacteria,2U1FH@28211|Alphaproteobacteria,3K3AB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Bacterial membrane protein, YfhO	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_347889_2	667632.KB890219_gene554	5.296e-154	499.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VJJ6@28216|Betaproteobacteria,1K0AP@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
TLS2_k127_347889_3	1110502.TMO_1559	1.333e-152	501.0	COG0624@1|root,COG0624@2|Bacteria,1MW2W@1224|Proteobacteria,2TQYZ@28211|Alphaproteobacteria,2JPP8@204441|Rhodospirillales	204441|Rhodospirillales	E	Peptidase dimerisation domain	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_347889_5	1316936.K678_14080	5.422e-73	257.0	COG1024@1|root,COG1024@2|Bacteria,1R446@1224|Proteobacteria,2U280@28211|Alphaproteobacteria,2JWEY@204441|Rhodospirillales	204441|Rhodospirillales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_347889_8	1205680.CAKO01000038_gene2017	7.156e-10	62.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JVG3@204441|Rhodospirillales	204441|Rhodospirillales	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_3480693_8	717785.HYPMC_2877	3.662e-17	87.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,3N673@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA polymerase	dnaE	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS2_k127_3480693_4	1342301.JASD01000008_gene2420	1.651e-77	268.0	COG1011@1|root,COG1011@2|Bacteria,1MU1H@1224|Proteobacteria,2TQVC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Haloacid dehalogenase	MA20_30570	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_3480693_3	258594.RPA1188	8.935e-103	348.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2TRPZ@28211|Alphaproteobacteria,3JR2K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Poly A polymerase head domain	pcnB	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
TLS2_k127_3480693_9	1267005.KB911256_gene2034	1.543e-15	89.0	2EPR2@1|root,33HBI@2|Bacteria,1NKAP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3480693_5	1267005.KB911256_gene2035	4.979e-65	229.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria,3N7C1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	NUDIX domain	MA20_44635	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_3480693_2	1267005.KB911262_gene3333	8.536e-107	356.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TVFA@28211|Alphaproteobacteria,3N6UY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Transporter associated domain	tlyC	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
TLS2_k127_3480693_6	1267005.KB911262_gene3332	2.062e-40	160.0	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,2UBXV@28211|Alphaproteobacteria,3N76N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
TLS2_k127_3480693_1	717785.HYPMC_4774	1.466e-146	473.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2TRV3@28211|Alphaproteobacteria,3N68S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	PhoH-like protein	phoH	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
TLS2_k127_3480693_0	402881.Plav_3617	7.467e-182	586.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2TQN6@28211|Alphaproteobacteria,1JNKR@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TLS2_k127_3480693_7	582899.Hden_2449	3.231e-32	134.0	COG0352@1|root,COG0352@2|Bacteria,1MV42@1224|Proteobacteria,2TSSA@28211|Alphaproteobacteria,3N7CC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Thiamine monophosphate synthase	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TLS2_k127_3480693_10	717785.HYPMC_0991	1.665e-11	73.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,3N70G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
TLS2_k127_3487126_5	1223521.BBJX01000002_gene2672	2.298e-06	56.0	COG0500@1|root,COG0500@2|Bacteria,1RDRV@1224|Proteobacteria,2WI0N@28216|Betaproteobacteria,4AK51@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_3487126_1	582899.Hden_0694	1.321e-181	575.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,2U4AQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
TLS2_k127_3487126_4	335659.S23_24970	4.367e-32	141.0	2DNQD@1|root,32YJR@2|Bacteria,1RIG5@1224|Proteobacteria,2U9TI@28211|Alphaproteobacteria,3JZTU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3303)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3303
TLS2_k127_3487126_2	582899.Hden_0693	4.849e-120	389.0	COG1150@1|root,COG1150@2|Bacteria,1R874@1224|Proteobacteria,2U3QM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_9
TLS2_k127_3487126_3	582899.Hden_0692	3.189e-100	340.0	arCOG05916@1|root,30GTU@2|Bacteria,1RDX8@1224|Proteobacteria,2U853@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3487126_0	582899.Hden_0691	2.199e-183	577.0	COG1148@1|root,COG1148@2|Bacteria,1R882@1224|Proteobacteria,2U526@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Pyr_redox_2
TLS2_k127_3491674_1	582899.Hden_2752	2.038e-170	538.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2TQQP@28211|Alphaproteobacteria,3N6EV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
TLS2_k127_3491674_7	1122132.AQYH01000020_gene112	3.798e-63	228.0	COG0697@1|root,COG0697@2|Bacteria,1MY2U@1224|Proteobacteria,2TV71@28211|Alphaproteobacteria,4B7EM@82115|Rhizobiaceae	28211|Alphaproteobacteria	EG	Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
TLS2_k127_3491674_6	991905.SL003B_2812	5.994e-64	231.0	COG0697@1|root,COG0697@2|Bacteria,1MY2U@1224|Proteobacteria,2TV71@28211|Alphaproteobacteria,4BQHI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
TLS2_k127_3491674_5	991905.SL003B_2812	4.189e-74	262.0	COG0697@1|root,COG0697@2|Bacteria,1MY2U@1224|Proteobacteria,2TV71@28211|Alphaproteobacteria,4BQHI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
TLS2_k127_3491674_0	1037409.BJ6T_15750	4.957e-180	572.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,3JTSN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3,DUF1643
TLS2_k127_3491674_2	717785.HYPMC_1924	2.088e-163	529.0	COG3106@1|root,COG3106@2|Bacteria,1MX6E@1224|Proteobacteria,2TR9Y@28211|Alphaproteobacteria,3N6JM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	YcjX-like family, DUF463	MA20_04550	-	-	ko:K06918	-	-	-	-	ko00000	-	-	-	DUF463
TLS2_k127_3491674_4	670307.HYPDE_30093	1.613e-101	342.0	COG3768@1|root,COG3768@2|Bacteria,1MU8S@1224|Proteobacteria,2TU53@28211|Alphaproteobacteria,3N6UG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF697)	MA20_04555	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K08990	-	-	-	-	ko00000	-	-	-	DUF697
TLS2_k127_3491674_3	1380355.JNIJ01000004_gene2851	3.834e-158	505.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,3JUPN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	GMC oxidoreductase	MA20_01285	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_3493372_8	582899.Hden_0688	7.295e-09	58.0	COG2044@1|root,COG2044@2|Bacteria,1RGWS@1224|Proteobacteria,2UB97@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
TLS2_k127_3493372_3	1354722.JQLS01000008_gene1711	1.98e-70	250.0	COG0697@1|root,COG0697@2|Bacteria,1MV7Y@1224|Proteobacteria,2TUVM@28211|Alphaproteobacteria,46PMS@74030|Roseovarius	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_3493372_4	314265.R2601_25606	5.352e-62	233.0	COG0697@1|root,COG0697@2|Bacteria,1MV7Y@1224|Proteobacteria,2TUVM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_3493372_0	582899.Hden_1637	6.593e-199	626.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2TS5P@28211|Alphaproteobacteria,3N82V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	VWA domain containing CoxE-like protein	MA20_01305	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS2_k127_3493372_2	420324.KI912031_gene2877	1.973e-108	356.0	COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,2TTT6@28211|Alphaproteobacteria,1JTNI@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	PFAM Integral membrane protein TerC	terC	-	-	-	-	-	-	-	-	-	-	-	TerC
TLS2_k127_3493372_6	1230476.C207_06540	5.445e-43	168.0	2E0TE@1|root,32WB2@2|Bacteria,1NBE9@1224|Proteobacteria,2UGU5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3493372_5	717785.HYPMC_3832	5.182e-59	208.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,2U77Q@28211|Alphaproteobacteria,3N6Y6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.1,3.5.4.3,3.5.4.33	ko:K01485,ko:K01487,ko:K11991	ko00230,ko00240,ko00330,ko01100,map00230,map00240,map00330,map01100	-	R00974,R01411,R01676,R02922,R10223	RC00074,RC00204,RC00477,RC00514,RC00809	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
TLS2_k127_3493372_1	1267005.KB911255_gene2698	7.252e-118	395.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2TQP2@28211|Alphaproteobacteria,3N6JT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_3493372_7	670307.HYPDE_36568	1.969e-33	132.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2U70Y@28211|Alphaproteobacteria,3N6TT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
TLS2_k127_3501585_1	1267005.KB911262_gene3368	3.754e-121	396.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria,3N6IA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_3501585_11	1044.EH31_03420	4.253e-47	177.0	COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,2U7AN@28211|Alphaproteobacteria,2K570@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
TLS2_k127_3501585_9	1267005.KB911256_gene1974	2.834e-59	207.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2UBWJ@28211|Alphaproteobacteria,3N748@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the HesB IscA family	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009058,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0018130,GO:0019438,GO:0019538,GO:0022607,GO:0031163,GO:0031974,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0070013,GO:0071704,GO:0071840,GO:0097428,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TLS2_k127_3501585_4	1205680.CAKO01000037_gene1225	1.115e-91	329.0	COG0477@1|root,COG2814@2|Bacteria,1R7QS@1224|Proteobacteria,2TUXM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_3501585_7	1547437.LL06_05175	2.817e-62	226.0	COG0697@1|root,COG0697@2|Bacteria,1MXX1@1224|Proteobacteria,2TQN0@28211|Alphaproteobacteria,43GTI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	MA20_09090	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_3501585_13	991905.SL003B_2822	1.445e-33	135.0	COG3439@1|root,COG3439@2|Bacteria,1RHPD@1224|Proteobacteria,2U95F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
TLS2_k127_3501585_8	582899.Hden_3159	9.821e-62	214.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2U98K@28211|Alphaproteobacteria,3N6Z8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4,Fer4_4
TLS2_k127_3501585_5	582899.Hden_3158	1.657e-85	298.0	COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,2TTVP@28211|Alphaproteobacteria,3N6QG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	CarD-like/TRCF domain	carD	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
TLS2_k127_3501585_3	37919.EP51_25300	2.866e-94	325.0	COG2072@1|root,COG2072@2|Bacteria,2GMDH@201174|Actinobacteria,4FYI4@85025|Nocardiaceae	201174|Actinobacteria	P	L-lysine 6-monooxygenase (NADPH-requiring)	pedG	-	-	-	-	-	-	-	-	-	-	-	FMO-like
TLS2_k127_3501585_14	1207063.P24_14449	1.479e-30	125.0	2DMP1@1|root,32SS8@2|Bacteria,1MZTD@1224|Proteobacteria,2UCPQ@28211|Alphaproteobacteria,2JYGV@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF3237)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3237
TLS2_k127_3501585_12	1197906.CAJQ02000022_gene4226	1.547e-46	176.0	COG1416@1|root,COG1416@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
TLS2_k127_3501585_10	1267005.KB911257_gene917	6.862e-53	194.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2U7FV@28211|Alphaproteobacteria,3N6WX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
TLS2_k127_3501585_6	1336243.JAEA01000012_gene2960	1.778e-72	252.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,2U74E@28211|Alphaproteobacteria,1JRVP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM lipolytic protein G-D-S-L family	tesA	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
TLS2_k127_3501585_2	1267005.KB911257_gene915	2.81e-95	317.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2TS0J@28211|Alphaproteobacteria,3N6UK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3501585_0	1267005.KB911257_gene914	1.633e-263	833.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria,3N6G9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	FtsX-like permease family	MA20_43810	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_3526919_3	1038860.AXAP01000126_gene1938	3.689e-116	382.0	COG1960@1|root,COG1960@2|Bacteria,1MW0F@1224|Proteobacteria,2TR9I@28211|Alphaproteobacteria,3JT6C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3526919_4	196490.AUEZ01000014_gene2038	3.127e-108	363.0	28JJ3@1|root,2Z9C7@2|Bacteria,1R3Y0@1224|Proteobacteria,2U0DT@28211|Alphaproteobacteria,3JSF4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	MA20_22330	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3526919_5	1502851.FG93_04246	8.067e-108	371.0	COG0684@1|root,COG0684@2|Bacteria,1MUWV@1224|Proteobacteria,2TU1X@28211|Alphaproteobacteria,3JTSK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Aldolase/RraA	MA20_39210	-	-	-	-	-	-	-	-	-	-	-	RraA-like
TLS2_k127_3526919_6	1267005.KB911259_gene3826	5.114e-102	339.0	COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,2U1U3@28211|Alphaproteobacteria,3N8K9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_3526919_0	648757.Rvan_3023	0.0	1268.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2TQV4@28211|Alphaproteobacteria,3N6II@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS2_k127_3526919_12	1267005.KB911258_gene354	1.702e-25	111.0	COG0593@1|root,COG0593@2|Bacteria,1N76V@1224|Proteobacteria,2UG3R@28211|Alphaproteobacteria,3N7FJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Bacterial dnaA protein helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C
TLS2_k127_3526919_10	717785.HYPMC_2408	3.712e-37	156.0	COG0583@1|root,COG0583@2|Bacteria,1MXC9@1224|Proteobacteria,2TTTY@28211|Alphaproteobacteria,3N7GR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3526919_9	398525.KB900701_gene5289	1.093e-47	176.0	COG1853@1|root,COG1853@2|Bacteria,1MZKY@1224|Proteobacteria,2U22K@28211|Alphaproteobacteria,3K6FE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Flavin reductase like domain	-	-	1.16.8.1	ko:K09024,ko:K13786	ko00240,ko00860,ko01100,map00240,map00860,map01100	-	R05218,R09936	RC01010,RC02732	ko00000,ko00001,ko01000	-	-	-	Flavin_Reduct
TLS2_k127_3526919_1	1054213.HMPREF9946_00573	3.321e-201	635.0	COG2141@1|root,COG2141@2|Bacteria,1MUVN@1224|Proteobacteria,2TR26@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_3526919_2	1205680.CAKO01000038_gene1597	1.687e-177	561.0	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3526919_7	582899.Hden_1974	1.61e-99	347.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2TR40@28211|Alphaproteobacteria,3N6FF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190,2.1.1.35	ko:K00557,ko:K03215	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	tRNA_U5-meth_tr
TLS2_k127_3526919_8	582899.Hden_1975	7.961e-71	245.0	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,2TRW9@28211|Alphaproteobacteria,3N6RP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	FtsJ-like methyltransferase	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
TLS2_k127_3534554_11	438753.AZC_4651	6.658e-51	186.0	COG5321@1|root,COG5321@2|Bacteria,1RDXW@1224|Proteobacteria,2U73Y@28211|Alphaproteobacteria,3EZIC@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	DNA repair protein MmcB-like	MA20_23405	-	-	-	-	-	-	-	-	-	-	-	MmcB-like
TLS2_k127_3534554_6	582899.Hden_0013	1.422e-101	336.0	COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,2TSK7@28211|Alphaproteobacteria,3N6P2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	response regulator	actR	-	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
TLS2_k127_3534554_5	1267005.KB911257_gene715	8.471e-142	464.0	COG0642@1|root,COG0642@2|Bacteria,1QU3Y@1224|Proteobacteria,2TVYH@28211|Alphaproteobacteria,3N9IC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	regB	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
TLS2_k127_3534554_9	1267005.KB911257_gene712	1.59e-62	224.0	COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2U0Q3@28211|Alphaproteobacteria,3N74Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	protein SCO1 SenC	msp5	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
TLS2_k127_3534554_16	391626.OAN307_c26900	1.516e-30	126.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	MA20_23315	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_3534554_4	1267005.KB911257_gene711	5.388e-189	605.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2TQXW@28211|Alphaproteobacteria,3N850@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	PHB de-polymerase C-terminus	phaZ	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	PHB_depo_C
TLS2_k127_3534554_7	1267005.KB911256_gene1482	3.297e-75	260.0	COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2U1JG@28211|Alphaproteobacteria,3N705@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function DUF45	MA20_23375	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
TLS2_k127_3534554_3	460265.Mnod_7392	8.739e-200	628.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,1JTJD@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM FMN-dependent alpha-hydroxy acid dehydrogenase	-	-	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100	-	R00196	RC00044	ko00000,ko00001,ko01000	-	-	-	FMN_dh
TLS2_k127_3534554_15	1267005.KB911263_gene1363	9.569e-33	135.0	COG0828@1|root,COG0828@2|Bacteria,1MZA1@1224|Proteobacteria,2UC58@28211|Alphaproteobacteria,3N796@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
TLS2_k127_3534554_8	1267005.KB911258_gene454	2.197e-68	236.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2U74V@28211|Alphaproteobacteria,3N6TW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
TLS2_k127_3534554_2	1197906.CAJQ02000023_gene2226	7.245e-209	655.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2TR4P@28211|Alphaproteobacteria,3JTYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
TLS2_k127_3534554_1	717785.HYPMC_2138	7.184e-213	667.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2TR3W@28211|Alphaproteobacteria,3N61G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
TLS2_k127_3534554_0	1267005.KB911257_gene945	0.0	1092.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria,3N6AQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_3534554_13	1500257.JQNM01000004_gene212	5.656e-45	166.0	COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,2UC3G@28211|Alphaproteobacteria,4BMRV@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS2_k127_3534554_14	670307.HYPDE_39533	2.142e-43	163.0	COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,2UC47@28211|Alphaproteobacteria,3N7AM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	succinate dehydrogenase	sdhC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS2_k127_3534554_12	331869.BAL199_01164	1.084e-50	196.0	COG2271@1|root,COG2271@2|Bacteria,1R8Q1@1224|Proteobacteria,2U16E@28211|Alphaproteobacteria,4BSQM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_3534554_10	189753.AXAS01000066_gene6138	5.356e-52	189.0	COG1052@1|root,COG1052@2|Bacteria,1MVSS@1224|Proteobacteria,2TR35@28211|Alphaproteobacteria,3JQNA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_3554569_0	220664.PFL_5084	3.37e-171	545.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPGB@1236|Gammaproteobacteria,1YRA2@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3554569_2	1380391.JIAS01000017_gene550	6.774e-31	129.0	COG0457@1|root,COG0457@2|Bacteria,1N0DE@1224|Proteobacteria,2UCGA@28211|Alphaproteobacteria,2JTE7@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2
TLS2_k127_3554569_1	1205680.CAKO01000006_gene3328	2.86e-135	441.0	COG2755@1|root,COG2755@2|Bacteria,1NHW6@1224|Proteobacteria,2UK9W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3554569_3	288000.BBta_2938	4.062e-16	82.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQMB@28211|Alphaproteobacteria,3JSMG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
TLS2_k127_3566317_1	631454.N177_0906	0.0	1379.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,1JN4R@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Bacterial NAD-glutamate dehydrogenase	gdhB	GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
TLS2_k127_3566317_4	1267005.KB911257_gene920	1.261e-179	574.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2TSCV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Major facilitator superfamily	MA20_25070	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
TLS2_k127_3566317_5	717785.HYPMC_2499	4.186e-175	561.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2TQWS@28211|Alphaproteobacteria,3N6EU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	homoserine dehydrogenase	hom	GO:0003674,GO:0003824,GO:0004412,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
TLS2_k127_3566317_7	582899.Hden_2611	8.153e-95	322.0	COG3820@1|root,COG3820@2|Bacteria,1MVR2@1224|Proteobacteria,2TT8Z@28211|Alphaproteobacteria,3N6PJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1013)	MA20_20925	-	-	ko:K09987	-	-	-	-	ko00000	-	-	-	DUF1013
TLS2_k127_3566317_9	864069.MicloDRAFT_00015410	1.638e-64	228.0	COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,2VGB4@28211|Alphaproteobacteria,1JS4K@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	2-hydroxychromene-2-carboxylate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
TLS2_k127_3566317_3	1267005.KB911258_gene621	1.055e-197	640.0	COG0658@1|root,COG0658@2|Bacteria,1MUKF@1224|Proteobacteria,2TRD5@28211|Alphaproteobacteria,3N62J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4131)	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131
TLS2_k127_3566317_13	935840.JAEQ01000005_gene1187	1.62e-16	81.0	COG0257@1|root,COG0257@2|Bacteria,1NGBJ@1224|Proteobacteria,2UJAG@28211|Alphaproteobacteria,43MDV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
TLS2_k127_3566317_6	1267005.KB911259_gene3893	6.93e-131	422.0	COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,2TS4S@28211|Alphaproteobacteria,3N67E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	YmdB-like protein	MA20_17970	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
TLS2_k127_3566317_10	1267005.KB911259_gene3892	3.313e-59	214.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2UBY4@28211|Alphaproteobacteria,3N73S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	MA20_17975	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
TLS2_k127_3566317_12	639283.Snov_3853	8.694e-19	91.0	2E4CR@1|root,312YR@2|Bacteria,1Q6V3@1224|Proteobacteria,2VCXR@28211|Alphaproteobacteria,3F03P@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	NADH-dependant formate dehydrogenase delta subunit FdsD	-	-	1.17.1.9	ko:K00126	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	FdsD
TLS2_k127_3566317_8	316055.RPE_4646	2.761e-86	295.0	COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,2TUD2@28211|Alphaproteobacteria,3JSY6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
TLS2_k127_3566317_0	1532558.JL39_25285	0.0	1701.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria,4BAAT@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	formate dehydrogenase	fdsA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
TLS2_k127_3566317_2	794846.AJQU01000045_gene4332	8.26e-244	769.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria,4B8JS@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	NADH ubiquinone oxidoreductase, NADH-binding (51 kD) subunit	fdsB	-	1.6.5.3	ko:K00124,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
TLS2_k127_3566317_11	1122132.AQYH01000003_gene2980	9.715e-59	208.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,2U72T@28211|Alphaproteobacteria,4BBHA@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	NADH ubiquinone oxidoreductase 24 kD subunit	fdsG	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	2Fe-2S_thioredx
TLS2_k127_3607398_3	1123242.JH636437_gene6034	1.584e-18	89.0	COG1052@1|root,COG1052@2|Bacteria	2|Bacteria	CH	NAD binding	-	-	1.1.1.26,1.1.1.399,1.1.1.95	ko:K00015,ko:K00058	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020	R00717,R01388,R01513	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_3607398_1	1123229.AUBC01000012_gene2696	1.502e-77	268.0	COG3836@1|root,COG3836@2|Bacteria,1QY50@1224|Proteobacteria,2U2PU@28211|Alphaproteobacteria,3K41P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.2.20	ko:K01630	ko00053,map00053	-	R02754,R03277	RC00307,RC00435	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_3607398_2	1380394.JADL01000009_gene3409	1.094e-68	242.0	COG0028@1|root,COG0028@2|Bacteria,1R6QP@1224|Proteobacteria,2TXAJ@28211|Alphaproteobacteria,2JSEG@204441|Rhodospirillales	204441|Rhodospirillales	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
TLS2_k127_3607398_0	107636.JQNK01000002_gene359	1.699e-203	649.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,36XJI@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_3609957_2	582899.Hden_2549	9.339e-109	359.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2TU3T@28211|Alphaproteobacteria,3N6IP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodB	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
TLS2_k127_3609957_3	670307.HYPDE_35528	5.167e-28	120.0	COG1664@1|root,COG1664@2|Bacteria,1PE73@1224|Proteobacteria,2UJPE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS2_k127_3609957_1	1205680.CAKO01000002_gene2483	4.312e-113	371.0	COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,2TW0W@28211|Alphaproteobacteria,2JSVN@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_3609957_0	648757.Rvan_2060	0.0	1064.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2TR9G@28211|Alphaproteobacteria,3N626@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS2_k127_3714342_0	670307.HYPDE_34573	1.968e-115	375.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2TSHK@28211|Alphaproteobacteria,3N61T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_3714342_3	717785.HYPMC_0544	8.468e-67	233.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2U7CH@28211|Alphaproteobacteria,3N70F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
TLS2_k127_3714342_2	349102.Rsph17025_1842	1.444e-81	278.0	COG2860@1|root,COG2860@2|Bacteria,1RHQN@1224|Proteobacteria,2U6B7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
TLS2_k127_3714342_6	1267005.KB911265_gene3589	8.764e-39	148.0	COG5416@1|root,COG5416@2|Bacteria,1PKR5@1224|Proteobacteria,2UZCM@28211|Alphaproteobacteria,3N7EI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Pfam:DUF1049	-	-	-	-	-	-	-	-	-	-	-	-	LapA_dom
TLS2_k127_3714342_4	670307.HYPDE_34593	1.096e-45	166.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2UBR5@28211|Alphaproteobacteria,3N73M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_3714342_1	717785.HYPMC_0541	1.288e-114	378.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TSXA@28211|Alphaproteobacteria,3N6TC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	OU	signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TLS2_k127_3746632_8	377629.TERTU_3149	1.471e-177	561.0	COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,1RNFJ@1236|Gammaproteobacteria,2PP6F@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	T	PrkA AAA domain	yeaG	GO:0003674,GO:0003824,GO:0004672,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0042594,GO:0043170,GO:0043412,GO:0043562,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0140096,GO:1901564	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
TLS2_k127_3746632_49	622637.KE124774_gene3165	1.378e-27	114.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2UC0H@28211|Alphaproteobacteria,36YR8@31993|Methylocystaceae	28211|Alphaproteobacteria	G	PTS HPr component phosphorylation site	ptsH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006808,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0044424,GO:0044464,GO:0050789,GO:0051179,GO:0051234,GO:0065007,GO:0071702	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
TLS2_k127_3746632_38	744980.TRICHSKD4_1465	2.599e-56	199.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2U9E5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Phosphotransferase system mannose fructose-specific component IIA	manX	-	2.7.1.191	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1	-	-	EIIA-man
TLS2_k127_3746632_44	648757.Rvan_2414	4.207e-50	187.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,2TUER@28211|Alphaproteobacteria,3N6XU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
TLS2_k127_3746632_43	290397.Adeh_0022	4.116e-51	188.0	COG0346@1|root,COG0346@2|Bacteria,1RG38@1224|Proteobacteria	1224|Proteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_2
TLS2_k127_3746632_4	717785.HYPMC_2503	6.676e-206	650.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2TQW9@28211|Alphaproteobacteria,3N7W8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein	metY	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47,2.5.1.49	ko:K01738,ko:K01740	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R01287,R03601,R04859	RC00020,RC02814,RC02821,RC02848	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS2_k127_3746632_10	1411123.JQNH01000001_gene2388	2.232e-164	524.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TQSZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS2_k127_3746632_47	744980.TRICHSKD4_3277	7.998e-40	155.0	COG2199@1|root,COG3706@2|Bacteria,1RH2K@1224|Proteobacteria,2U9EP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Response regulator receiver	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
TLS2_k127_3746632_48	113395.AXAI01000010_gene2239	4.64e-35	137.0	COG0727@1|root,COG0727@2|Bacteria,1N37X@1224|Proteobacteria,2U95A@28211|Alphaproteobacteria,3JZEV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
TLS2_k127_3746632_51	1244869.H261_02196	1.4e-18	95.0	COG3416@1|root,COG3416@2|Bacteria,1P8CZ@1224|Proteobacteria,2U6C3@28211|Alphaproteobacteria,2JTI5@204441|Rhodospirillales	204441|Rhodospirillales	S	Uncharacterized protein conserved in bacteria (DUF2076)	-	-	-	ko:K09945	-	-	-	-	ko00000	-	-	-	DUF2076
TLS2_k127_3746632_35	1267005.KB911258_gene417	2.552e-58	211.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,3N92E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Rhomboid family	MA20_31620	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS2_k127_3746632_46	717785.HYPMC_2105	4.3e-44	169.0	COG5388@1|root,COG5388@2|Bacteria,1MXF0@1224|Proteobacteria,2U3WI@28211|Alphaproteobacteria,3N77W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PAS domain	MA20_31625	-	-	-	-	-	-	-	-	-	-	-	PAS_5
TLS2_k127_3746632_24	717785.HYPMC_3848	4.091e-111	368.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2TTUY@28211|Alphaproteobacteria,3N6T7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
TLS2_k127_3746632_37	1267005.KB911256_gene1813	4.289e-57	203.0	COG2030@1|root,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2U5CQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	dehydratase	-	GO:0003674,GO:0003824,GO:0003859,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0046487,GO:0071704	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
TLS2_k127_3746632_26	331869.BAL199_25574	1.117e-97	333.0	COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2TRA3@28211|Alphaproteobacteria,4BQ0F@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_3746632_2	1429916.X566_20415	7.641e-231	732.0	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,2TS9Q@28211|Alphaproteobacteria,3JTIR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter transmembrane region 2	MA20_43525	-	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2,ABC_tran
TLS2_k127_3746632_42	1082931.KKY_1281	3.96e-52	194.0	COG5343@1|root,COG5343@2|Bacteria,1RAJA@1224|Proteobacteria,2U95B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
TLS2_k127_3746632_39	1120792.JAFV01000001_gene1441	1.01e-55	200.0	COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2U6J3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_3746632_28	1509405.GV67_14285	7.159e-91	305.0	COG3291@1|root,COG3291@2|Bacteria,1N0V6@1224|Proteobacteria,2U316@28211|Alphaproteobacteria,4BNS7@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4394)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4394
TLS2_k127_3746632_34	68223.JNZY01000041_gene4414	6.291e-62	217.0	COG5485@1|root,COG5485@2|Bacteria,2GJYB@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
TLS2_k127_3746632_3	1122132.AQYH01000008_gene2343	1.45e-227	718.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2TUNK@28211|Alphaproteobacteria,4BCK6@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_3746632_23	404589.Anae109_1600	5.961e-113	374.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_N,Cupin_6,HTH_18
TLS2_k127_3746632_21	765913.ThidrDRAFT_1426	8.025e-118	396.0	COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,1RMBX@1236|Gammaproteobacteria,1WXBG@135613|Chromatiales	135613|Chromatiales	F	PFAM Na dependent nucleoside transporter	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
TLS2_k127_3746632_33	1123355.JHYO01000012_gene669	5.197e-65	236.0	COG3180@1|root,COG3180@2|Bacteria,1MUFS@1224|Proteobacteria,2TUUX@28211|Alphaproteobacteria,370TJ@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Transition state regulatory protein AbrB	-	-	-	ko:K07120	-	-	-	-	ko00000	-	-	-	AbrB
TLS2_k127_3746632_45	582899.Hden_3366	1.081e-46	173.0	COG3824@1|root,COG3824@2|Bacteria,1N18M@1224|Proteobacteria,2UBUK@28211|Alphaproteobacteria,3N75A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Zincin-like metallopeptidase	MA20_43655	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Zincin_1
TLS2_k127_3746632_31	1267005.KB911255_gene2620	8.299e-73	252.0	2BX5R@1|root,34AVN@2|Bacteria,1P2HF@1224|Proteobacteria,2UVQ3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3746632_36	991905.SL003B_0046	2.559e-57	209.0	COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,1N2YQ@1224|Proteobacteria,2TQRX@28211|Alphaproteobacteria,4BQ5Z@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	ada	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	DNA_binding_1,HTH_18
TLS2_k127_3746632_30	1267005.KB911259_gene3694	7.271e-80	273.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2U3RS@28211|Alphaproteobacteria,3N6W0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	riboflavin synthase, alpha	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
TLS2_k127_3746632_14	1267005.KB911259_gene3693	9.539e-152	496.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2TSMA@28211|Alphaproteobacteria,3N6N9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
TLS2_k127_3746632_41	582899.Hden_0965	2.044e-52	201.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2U9IZ@28211|Alphaproteobacteria,3N75M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
TLS2_k127_3746632_40	717785.HYPMC_2768	4.689e-53	197.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2UBQA@28211|Alphaproteobacteria,3N72C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
TLS2_k127_3746632_29	1429916.X566_09935	4.096e-88	297.0	COG0625@1|root,COG0625@2|Bacteria,1MWUG@1224|Proteobacteria,2TTZ6@28211|Alphaproteobacteria,3JSTS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Belongs to the GST superfamily	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_3,GST_N,GST_N_3
TLS2_k127_3746632_19	717785.HYPMC_1295	7.956e-126	424.0	COG0457@1|root,COG3063@1|root,COG0457@2|Bacteria,COG3063@2|Bacteria,1RKBA@1224|Proteobacteria,2TRAV@28211|Alphaproteobacteria,3N8A7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
TLS2_k127_3746632_9	1205680.CAKO01000038_gene1661	9.083e-169	536.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,2JPRD@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the ABC transporter superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
TLS2_k127_3746632_13	1429916.X566_16165	1.162e-154	496.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,3JSG0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Belongs to the ABC transporter superfamily	MA20_22935	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_3746632_16	1205680.CAKO01000038_gene1663	1.11e-140	453.0	COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,2TRX5@28211|Alphaproteobacteria,2JWI3@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_3746632_15	1205680.CAKO01000038_gene1664	1.015e-147	475.0	COG0601@1|root,COG0601@2|Bacteria,1R6TQ@1224|Proteobacteria,2VFHW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_3746632_1	1429916.X566_16185	6.994e-238	747.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria,3JQQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_3746632_22	1037409.BJ6T_70650	5.397e-115	377.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,3JSZZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	MA20_17615	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_3746632_32	1380394.JADL01000001_gene2358	2.229e-65	231.0	COG2128@1|root,COG2128@2|Bacteria,1PNA5@1224|Proteobacteria,2U0KT@28211|Alphaproteobacteria,2JWBA@204441|Rhodospirillales	204441|Rhodospirillales	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_3746632_20	1037409.BJ6T_70630	8.66e-125	404.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,3JWJX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_3746632_27	316057.RPD_0272	5.626e-94	316.0	COG1024@1|root,COG1024@2|Bacteria,1MWGT@1224|Proteobacteria,2TV7F@28211|Alphaproteobacteria,3JU1Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	MA20_40055	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_3746632_11	1380394.JADL01000001_gene2322	6.883e-159	533.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2JPV8@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1042 Acyl-CoA synthetase (NDP forming)	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
TLS2_k127_3746632_5	316057.RPD_0271	1.438e-205	644.0	COG1960@1|root,COG1960@2|Bacteria,1MW0F@1224|Proteobacteria,2TR9I@28211|Alphaproteobacteria,3JUIJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_40060	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3746632_17	1429916.X566_11195	5.047e-129	422.0	COG1960@1|root,COG1960@2|Bacteria,1NQAE@1224|Proteobacteria,2U0TJ@28211|Alphaproteobacteria,3JTKC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_40065	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
TLS2_k127_3746632_12	1121861.KB899925_gene2473	1.162e-156	517.0	COG5476@1|root,COG5476@2|Bacteria,1NS9S@1224|Proteobacteria,2UNYM@28211|Alphaproteobacteria,2JUXX@204441|Rhodospirillales	204441|Rhodospirillales	S	MlrC C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
TLS2_k127_3746632_7	1267005.KB911258_gene191	8.582e-178	572.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,3N6E5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TLS2_k127_3746632_18	670307.HYPDE_24143	3.143e-127	414.0	COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2TSFA@28211|Alphaproteobacteria,3N6E6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	Type II secretion system	tadC	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_3746632_25	1267005.KB911255_gene2907	7.555e-100	338.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2TRBI@28211|Alphaproteobacteria,3N6UV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Type II secretion system (T2SS), protein F	tadB	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_3746632_0	717785.HYPMC_0617	2.103e-264	820.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2TRNT@28211|Alphaproteobacteria,3N6JB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Type II/IV secretion system protein	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS2_k127_3746632_6	717785.HYPMC_0616	1.768e-179	569.0	COG0745@1|root,COG4963@1|root,COG0745@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2TUDS@28211|Alphaproteobacteria,3N6AI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	AAA domain	cpaE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ
TLS2_k127_3752545_12	991905.SL003B_3453	7.088e-81	282.0	COG4961@1|root,COG4961@2|Bacteria,1MWXU@1224|Proteobacteria,2TRQP@28211|Alphaproteobacteria,4BQFA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad,VWA
TLS2_k127_3752545_5	1267005.KB911255_gene2911	6.624e-125	417.0	COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2TRNN@28211|Alphaproteobacteria,3N6MY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Belongs to the GSP D family	cpaC	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
TLS2_k127_3752545_19	1267005.KB911255_gene2910	3.406e-22	109.0	COG5461@1|root,COG5461@2|Bacteria,1MWWE@1224|Proteobacteria,2TU2Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	TIGRFAM pilus (Caulobacter type) biogenesis lipoprotein CpaD	cpaD	-	-	ko:K02281	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Pilus_CpaD
TLS2_k127_3752545_18	412597.AEPN01000001_gene2986	2.989e-29	121.0	COG2388@1|root,COG2388@2|Bacteria,1N6YS@1224|Proteobacteria,2UG30@28211|Alphaproteobacteria,2PXH2@265|Paracoccus	28211|Alphaproteobacteria	S	GCN5-related N-acetyl-transferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
TLS2_k127_3752545_10	1267005.KB911264_gene3145	4.25e-102	337.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2TR4Z@28211|Alphaproteobacteria,3N7WS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the WrbA family	wrbA	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
TLS2_k127_3752545_8	1134912.AJTV01000059_gene4023	1.956e-107	353.0	COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,2TSR6@28211|Alphaproteobacteria,36YC6@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Pirin	MA20_06040	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
TLS2_k127_3752545_6	582899.Hden_3044	4.407e-124	405.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria,3N6UU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	MA20_14610	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_3752545_16	420324.KI912006_gene8649	2.472e-32	133.0	COG0778@1|root,COG0778@2|Bacteria,1PKUV@1224|Proteobacteria,2U5MZ@28211|Alphaproteobacteria,1JS66@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_3752545_17	883080.HMPREF9697_02189	1.904e-29	125.0	COG0526@1|root,COG0526@2|Bacteria,1PDVE@1224|Proteobacteria,2UDJR@28211|Alphaproteobacteria,3K0TN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_3752545_4	1038858.AXBA01000010_gene2723	4.919e-132	435.0	COG1305@1|root,COG1305@2|Bacteria,1MY5V@1224|Proteobacteria,2TU99@28211|Alphaproteobacteria,3EY4T@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TAT_signal,Transglut_core
TLS2_k127_3752545_3	1041146.ATZB01000034_gene559	8.157e-156	500.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,4BD23@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS2_k127_3752545_15	670307.HYPDE_24828	2.865e-36	142.0	COG2005@1|root,COG2005@2|Bacteria,1P9SX@1224|Proteobacteria,2UC9Q@28211|Alphaproteobacteria,3N79V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	ModE family	modE	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1
TLS2_k127_3752545_11	1231190.NA8A_10463	5.223e-82	280.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2U5B1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter, periplasmic molybdate-binding protein	modA	GO:0003674,GO:0005488,GO:0030973,GO:0043167,GO:0043168	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
TLS2_k127_3752545_9	1469613.JT55_03725	9.882e-107	349.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2TSYJ@28211|Alphaproteobacteria,3FCRU@34008|Rhodovulum	28211|Alphaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
TLS2_k127_3752545_7	316056.RPC_0708	5.587e-116	398.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2TR1Z@28211|Alphaproteobacteria,3JUD5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
TLS2_k127_3752545_13	1502851.FG93_05671	5.453e-61	213.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2U5PZ@28211|Alphaproteobacteria,3K4C6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
TLS2_k127_3752545_0	1126627.BAWE01000002_gene699	2.678e-198	630.0	COG3964@1|root,COG3964@2|Bacteria,1MVC7@1224|Proteobacteria,2TSUD@28211|Alphaproteobacteria,3JSBJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase family	MA20_40145	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
TLS2_k127_3752545_1	1267005.KB911256_gene1758	1.343e-181	580.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2TRUG@28211|Alphaproteobacteria,3N66M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
TLS2_k127_3752545_2	107636.JQNK01000008_gene4290	8.737e-161	519.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2TTE8@28211|Alphaproteobacteria,36X9S@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Mur ligase middle domain	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
TLS2_k127_3752545_20	717785.HYPMC_0335	2.56e-13	77.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2TQSA@28211|Alphaproteobacteria,3N6BH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
TLS2_k127_3755258_0	1267005.KB911256_gene1953	0.0	2185.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,3N6A5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TLS2_k127_3761802_17	59538.XP_005973860.1	1.652e-56	200.0	COG0838@1|root,KOG4662@2759|Eukaryota,3A8AU@33154|Opisthokonta	33154|Opisthokonta	C	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	nad3	-	1.6.5.3	ko:K03880	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Oxidored_q4
TLS2_k127_3761802_8	1267005.KB911260_gene3560	1.572e-107	359.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2TQK3@28211|Alphaproteobacteria,3N6IK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TLS2_k127_3761802_10	1267005.KB911260_gene3561	5.549e-95	315.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2TSMT@28211|Alphaproteobacteria,3N6N7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TLS2_k127_3761802_2	1245469.S58_56840	5.351e-188	602.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,3JSS3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	GMC oxidoreductase	MA20_44990	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_3761802_19	1121106.JQKB01000010_gene430	8.728e-16	84.0	COG3575@1|root,COG3575@2|Bacteria,1R5GH@1224|Proteobacteria,2U1BS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K09962	-	-	-	-	ko00000	-	-	-	NTP_transf_6
TLS2_k127_3761802_21	649831.L083_2542	2.126e-06	54.0	COG3575@1|root,COG3575@2|Bacteria,2GP2I@201174|Actinobacteria	201174|Actinobacteria	E	Nucleotidyltransferase	-	-	-	ko:K09962	-	-	-	-	ko00000	-	-	-	NTP_transf_6
TLS2_k127_3761802_6	1267005.KB911258_gene419	3.182e-124	406.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria,3N6X0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Patatin-like phospholipase	rssA	GO:0003674,GO:0003824,GO:0016787	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS2_k127_3761802_15	1121106.JQKB01000033_gene5918	2.882e-59	220.0	COG0697@1|root,COG0697@2|Bacteria,1R6KH@1224|Proteobacteria,2TTBR@28211|Alphaproteobacteria,2JS5P@204441|Rhodospirillales	204441|Rhodospirillales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_3761802_1	717785.HYPMC_3829	2.553e-198	632.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2TR1R@28211|Alphaproteobacteria,3N6IY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TLS2_k127_3761802_0	1267005.KB911263_gene1346	2.93e-205	646.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,3N6I7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
TLS2_k127_3761802_12	991905.SL003B_3421	1.008e-85	299.0	COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,2TREP@28211|Alphaproteobacteria,4BPYP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Alpha beta hydrolase	MA20_05720	-	3.8.1.3	ko:K01561	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_3761802_9	1038858.AXBA01000015_gene2123	9.839e-103	352.0	COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,2TREP@28211|Alphaproteobacteria,3EZJR@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	alpha/beta hydrolase fold	MA20_05720	-	3.8.1.3	ko:K01561	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_3761802_11	717785.HYPMC_3831	1.69e-86	298.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria,3N6X0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS2_k127_3761802_16	670307.HYPDE_36553	2.486e-57	215.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria,3N6X0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS2_k127_3761802_18	1040989.AWZU01000063_gene6241	1.469e-49	191.0	COG2146@1|root,COG2146@2|Bacteria,1RAKS@1224|Proteobacteria,2U5KH@28211|Alphaproteobacteria,3JY32@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Rieske-like [2Fe-2S] domain	MA20_19305	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
TLS2_k127_3761802_4	1089551.KE386572_gene2625	8.413e-147	474.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria,4BSZR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_3761802_5	1089551.KE386572_gene2624	2.866e-139	451.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria,4BSZR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Amidohydrolase	MA20_19310	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_3761802_3	1267005.KB911257_gene923	2.824e-166	541.0	COG5360@1|root,COG5360@2|Bacteria,1MUJ4@1224|Proteobacteria,2TR5G@28211|Alphaproteobacteria,3N6YX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Heparinase II/III-like protein	MA20_25080	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III
TLS2_k127_3761802_22	551789.ATVJ01000002_gene3079	4.739e-06	52.0	COG0640@1|root,COG0640@2|Bacteria,1N3ZI@1224|Proteobacteria,2UTV0@28211|Alphaproteobacteria,4411A@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_3761802_20	670307.HYPDE_37358	1.436e-13	76.0	2CGUP@1|root,2ZEI0@2|Bacteria,1P3YN@1224|Proteobacteria,2UWWG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3761802_7	1267005.KB911255_gene2640	9.129e-121	395.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2TSWX@28211|Alphaproteobacteria,3N62C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TLS2_k127_3761802_14	717785.HYPMC_0638	2.085e-64	239.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2U797@28211|Alphaproteobacteria,3N706@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.31,3.5.1.88	ko:K01450,ko:K01462	ko00270,ko00630,map00270,map00630	-	R00653	RC00165,RC00323	ko00000,ko00001,ko01000	-	-	-	Pep_deformylase
TLS2_k127_3761802_13	1123503.KB908056_gene1385	1.532e-79	287.0	COG0189@1|root,COG4067@1|root,COG0189@2|Bacteria,COG4067@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria,2KFBJ@204458|Caulobacterales	204458|Caulobacterales	HJO	Putative ATP-dependant zinc protease	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK,Zn_protease
TLS2_k127_3791656_0	1267005.KB911256_gene1656	0.0	1036.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2TRDD@28211|Alphaproteobacteria,3N64P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
TLS2_k127_3791656_12	349102.Rsph17025_1614	5.931e-09	61.0	2DQIZ@1|root,3376C@2|Bacteria,1N9ZR@1224|Proteobacteria,2UFPZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3791656_10	1267005.KB911256_gene1655	1.129e-32	132.0	COG1722@1|root,COG1722@2|Bacteria,1PTYQ@1224|Proteobacteria,2UFD6@28211|Alphaproteobacteria,3N773@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
TLS2_k127_3791656_2	1267005.KB911256_gene1654	9.011e-141	455.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TSX9@28211|Alphaproteobacteria,3N6CA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	BQ	histone deacetylase	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
TLS2_k127_3791656_9	1089551.KE386572_gene3801	3.141e-35	139.0	2E5W4@1|root,330K6@2|Bacteria,1PJII@1224|Proteobacteria,2VDW5@28211|Alphaproteobacteria,4BSQK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
TLS2_k127_3791656_11	349521.HCH_05484	3.967e-32	129.0	COG1359@1|root,COG1359@2|Bacteria,1MZM5@1224|Proteobacteria	1224|Proteobacteria	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3791656_8	1411123.JQNH01000001_gene1667	2.637e-36	143.0	COG1917@1|root,COG1917@2|Bacteria,1N7QJ@1224|Proteobacteria,2UFRZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Cupin 2 conserved barrel domain protein	MA20_03790	-	-	ko:K21700	-	-	-	-	ko00000	-	-	-	Cupin_2
TLS2_k127_3791656_7	1267005.KB911258_gene96	5.124e-43	162.0	COG4964@1|root,COG4964@2|Bacteria,1R3QI@1224|Proteobacteria,2UGFC@28211|Alphaproteobacteria,3N93Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Pilus formation protein N terminal region	pilQ	-	-	-	-	-	-	-	-	-	-	-	T2SS-T3SS_pil_N
TLS2_k127_3791656_1	1205680.CAKO01000002_gene2826	2.917e-179	571.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_3791656_6	1411123.JQNH01000001_gene3882	1.534e-110	368.0	COG1063@1|root,COG1063@2|Bacteria,1MWX0@1224|Proteobacteria,2TU6B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Dehydrogenase	yjjN	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034193,GO:0034195,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.14,1.1.1.380	ko:K00008,ko:K08322	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896,R10848	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_3791656_3	582899.Hden_2785	3.882e-126	408.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQQG@28211|Alphaproteobacteria,3N7HS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	MA20_19215	-	5.3.3.10	ko:K01826	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R04379,R04482	RC01141,RC01162	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
TLS2_k127_3791656_5	883078.HMPREF9695_04061	1.253e-115	378.0	COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,2TSNX@28211|Alphaproteobacteria,3JQUD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Dehydrogenase	MA20_18560	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_3791656_4	1429916.X566_11300	1.275e-125	412.0	COG3181@1|root,COG3181@2|Bacteria,1N7C4@1224|Proteobacteria,2TTPJ@28211|Alphaproteobacteria,3JVV2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	MA20_23135	-	-	-	-	-	-	-	-	-	-	-	TctC
TLS2_k127_3798815_9	1267005.KB911256_gene1851	7.504e-07	55.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,3N673@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA polymerase	dnaE	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS2_k127_3798815_5	1211579.PP4_35750	2.03e-83	284.0	COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,1RRE1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_3798815_2	864069.MicloDRAFT_00036430	1.692e-137	448.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,1JUCM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system	ugpC	-	3.6.3.20	ko:K05816	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1.3	-	-	ABC_tran,TOBE_2
TLS2_k127_3798815_4	1123229.AUBC01000010_gene3305	5.206e-118	387.0	COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,2TSYA@28211|Alphaproteobacteria,3JQM9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	probably responsible for the translocation of the substrate across the membrane	ugpE	-	-	ko:K05815	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
TLS2_k127_3798815_3	1207063.P24_14739	5.751e-131	424.0	COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,2TSGN@28211|Alphaproteobacteria,2JQ6I@204441|Rhodospirillales	204441|Rhodospirillales	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05814	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
TLS2_k127_3798815_1	331869.BAL199_10135	4.987e-237	737.0	COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,2TQKV@28211|Alphaproteobacteria,4BPN6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	ugpB	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
TLS2_k127_3798815_0	582899.Hden_0371	0.0	1067.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2TR3H@28211|Alphaproteobacteria,3N69J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
TLS2_k127_3798815_6	990073.ATHU01000001_gene1182	1.538e-71	258.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2YN7C@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
TLS2_k127_3798815_8	1178482.BJB45_02615	3.069e-07	60.0	COG3090@1|root,COG3090@2|Bacteria,1MVKS@1224|Proteobacteria	1224|Proteobacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_3798815_7	1121033.AUCF01000017_gene3776	2.436e-11	75.0	COG1638@1|root,COG1638@2|Bacteria,1P3MK@1224|Proteobacteria,2TVQB@28211|Alphaproteobacteria,2JQ37@204441|Rhodospirillales	204441|Rhodospirillales	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
TLS2_k127_3802678_16	398525.KB900701_gene6608	4.744e-69	250.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2U5CW@28211|Alphaproteobacteria,3JS41@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Acetolactate synthase small subunit	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
TLS2_k127_3802678_13	717785.HYPMC_1460	4.686e-85	287.0	COG0625@1|root,COG0625@2|Bacteria,1PHM1@1224|Proteobacteria,2TTQZ@28211|Alphaproteobacteria,3N6YD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	gstch10	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
TLS2_k127_3802678_0	1267005.KB911258_gene170	0.0	1022.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria,3N621@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Acetolactate synthase	ilvI	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_3802678_7	582899.Hden_2081	1.854e-109	361.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2TR8Z@28211|Alphaproteobacteria,3N6UJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
TLS2_k127_3802678_18	1267005.KB911256_gene2047	3.234e-57	204.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2U98Y@28211|Alphaproteobacteria,3N6VB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	ruvX	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
TLS2_k127_3802678_14	1231185.BAMP01000015_gene1790	1.904e-80	278.0	COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,2TV26@28211|Alphaproteobacteria,43IZZ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
TLS2_k127_3802678_2	1267005.KB911256_gene2048	6.785e-280	882.0	COG0421@1|root,COG0421@2|Bacteria,1N1PJ@1224|Proteobacteria,2TUJQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	MA20_01900	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3802678_11	1120983.KB894571_gene2194	3.607e-91	304.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria,1JNUA@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
TLS2_k127_3802678_23	1267005.KB911259_gene3934	1.396e-30	126.0	COG4520@1|root,COG4520@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3802678_12	663610.JQKO01000005_gene2468	7.182e-89	302.0	COG0697@1|root,COG0697@2|Bacteria,1PHRI@1224|Proteobacteria,2TUAQ@28211|Alphaproteobacteria,3NB3U@45404|Beijerinckiaceae	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	MA20_39710	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_3802678_10	1267005.KB911255_gene3029	1.214e-99	340.0	COG0457@1|root,COG0457@2|Bacteria	1267005.KB911255_gene3029|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3802678_17	717785.HYPMC_2987	4.864e-67	244.0	COG0860@1|root,COG0860@2|Bacteria	2|Bacteria	M	N-Acetylmuramoyl-L-alanine amidase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
TLS2_k127_3802678_9	118161.KB235922_gene2853	5.808e-100	349.0	COG0515@1|root,COG0515@2|Bacteria	118161.KB235922_gene2853|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3802678_1	582899.Hden_1649	8.734e-300	928.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,3N620@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
TLS2_k127_3802678_21	1123072.AUDH01000014_gene1312	6.096e-37	156.0	COG2133@1|root,COG2133@2|Bacteria,1R26Q@1224|Proteobacteria,2TZBT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Putative lumazine-binding	-	-	-	-	-	-	-	-	-	-	-	-	Lumazine_bd_2
TLS2_k127_3802678_8	488538.SAR116_1471	4.577e-108	364.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
TLS2_k127_3802678_6	1502851.FG93_06211	1.972e-114	373.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,3JU3S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Belongs to the GST superfamily	gst7	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_N,GST_N_3
TLS2_k127_3802678_19	1380394.JADL01000002_gene1300	1.706e-42	172.0	COG2355@1|root,COG2355@2|Bacteria,1RG53@1224|Proteobacteria,2UE31@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
TLS2_k127_3802678_20	582899.Hden_0380	1.977e-39	149.0	2CCXR@1|root,2ZRYB@2|Bacteria,1P7YK@1224|Proteobacteria,2UYNB@28211|Alphaproteobacteria,3N998@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3802678_15	670307.HYPDE_36733	2.063e-78	270.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,2UAKC@28211|Alphaproteobacteria,3N72Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,Peptidase_S9
TLS2_k127_3802678_5	316058.RPB_2703	7.12e-120	394.0	COG1024@1|root,COG1024@2|Bacteria,1NJ9M@1224|Proteobacteria,2U07X@28211|Alphaproteobacteria,3JR0Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	MA20_29580	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_3802678_4	1205680.CAKO01000035_gene252	2.955e-130	424.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2TVJ9@28211|Alphaproteobacteria,2JW6Y@204441|Rhodospirillales	204441|Rhodospirillales	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_3820610_1	1267005.KB911255_gene2605	1.113e-98	327.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2TSIZ@28211|Alphaproteobacteria,3N6BA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
TLS2_k127_3820610_2	1120983.KB894570_gene1448	2.884e-52	199.0	COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,2TQWY@28211|Alphaproteobacteria,1JP7J@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	NnrU protein	nnrU	-	-	-	-	-	-	-	-	-	-	-	NnrU
TLS2_k127_3820610_3	1122135.KB893144_gene1405	1.437e-46	175.0	COG3821@1|root,COG3821@2|Bacteria,1RDXR@1224|Proteobacteria,2TTTD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF599
TLS2_k127_3820610_0	113395.AXAI01000030_gene2661	9.594e-202	638.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,3JSVT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_3820610_4	1532558.JL39_29935	8.812e-13	69.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,2TRIC@28211|Alphaproteobacteria,4BAV1@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	membrane transporter protein	MA20_19835	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_3873064_7	1123072.AUDH01000002_gene2554	5.652e-135	449.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQY7@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_3873064_10	1380355.JNIJ01000007_gene3228	2.618e-79	280.0	COG0683@1|root,COG0683@2|Bacteria,1MVV2@1224|Proteobacteria,2TRFU@28211|Alphaproteobacteria,3K2UM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_3873064_9	1380355.JNIJ01000007_gene3230	2.065e-93	314.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2TSCF@28211|Alphaproteobacteria,3JQTN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
TLS2_k127_3873064_13	1380355.JNIJ01000007_gene3229	3.968e-62	228.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2UPGN@28211|Alphaproteobacteria,3K2V1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
TLS2_k127_3873064_12	1038858.AXBA01000028_gene1002	6.105e-65	244.0	COG0411@1|root,COG0411@2|Bacteria,1QUC5@1224|Proteobacteria,2U1AQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_3873064_11	1118054.CAGW01000061_gene2426	2.036e-68	241.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,4HABJ@91061|Bacilli,26RRC@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_3873064_4	196490.AUEZ01000004_gene4100	2.006e-174	561.0	COG1653@1|root,COG1653@2|Bacteria,1MXY4@1224|Proteobacteria,2TS7N@28211|Alphaproteobacteria,3JU4D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_3873064_2	1411123.JQNH01000001_gene1761	4.822e-219	687.0	COG1653@1|root,COG1653@2|Bacteria,1MXY4@1224|Proteobacteria,2TS7N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_3873064_6	1038859.AXAU01000001_gene3224	1.51e-154	492.0	COG1175@1|root,COG1175@2|Bacteria,1MXKR@1224|Proteobacteria,2TRDJ@28211|Alphaproteobacteria,3JUDP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	MA20_13200	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_3873064_5	1297865.APJD01000026_gene2480	5.582e-155	505.0	COG0395@1|root,COG0395@2|Bacteria,1PG6Q@1224|Proteobacteria,2U1HZ@28211|Alphaproteobacteria,3JTY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	MA20_13195	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_3873064_3	224911.27352820	2.442e-182	592.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,3JT2D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ABC transporter	MA20_13190	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
TLS2_k127_3873064_14	582899.Hden_0748	1.351e-38	157.0	COG0810@1|root,COG0810@2|Bacteria,1PGCD@1224|Proteobacteria,2UKWB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	TonB C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_2
TLS2_k127_3873064_1	582899.Hden_0746	1.292e-234	743.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria,3N882@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	TonB dependent receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
TLS2_k127_3873064_8	1353537.TP2_02855	2.483e-112	375.0	COG0614@1|root,COG0614@2|Bacteria,1PK1C@1224|Proteobacteria,2TRF4@28211|Alphaproteobacteria,2XKIN@285107|Thioclava	28211|Alphaproteobacteria	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS2_k127_3873064_0	84531.JMTZ01000008_gene3359	9.369e-254	807.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RPRP@1236|Gammaproteobacteria,1X56U@135614|Xanthomonadales	135614|Xanthomonadales	S	Penicillin acylase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS2_k127_3873064_15	1041159.AZUW01000009_gene4580	2.759e-27	112.0	COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,2U6XJ@28211|Alphaproteobacteria,4BM7P@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Domain of unknown function (DUF1956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1956,TetR_N
TLS2_k127_3879303_1	1267005.KB911259_gene3834	3.546e-131	426.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,3N67Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
TLS2_k127_3879303_5	1340493.JNIF01000003_gene1554	1.408e-11	70.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_3879303_4	1509405.GV67_07745	1.538e-44	168.0	COG3791@1|root,COG3791@2|Bacteria,1NUVZ@1224|Proteobacteria,2URRI@28211|Alphaproteobacteria,4BMTF@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS2_k127_3879303_0	1267005.KB911255_gene2967	1.541e-163	522.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2TQQB@28211|Alphaproteobacteria,3N6ET@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Elongator protein 3, MiaB family, Radical SAM	MA20_42330	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_3879303_3	1381123.AYOD01000015_gene2378	3.344e-51	187.0	COG2320@1|root,COG2320@2|Bacteria,1N37V@1224|Proteobacteria,2UD0B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	GrpB protein	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
TLS2_k127_3879303_2	402881.Plav_0708	2.448e-83	284.0	COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,2TXAA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferase group 2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS2_k127_3879303_6	1041147.AUFB01000025_gene6060	3.856e-08	59.0	COG0491@1|root,COG0491@2|Bacteria,1MY6G@1224|Proteobacteria,2TTBX@28211|Alphaproteobacteria,4BAH7@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_3885052_2	717785.HYPMC_0526	6.205e-63	225.0	2FGBJ@1|root,3487V@2|Bacteria,1P1I6@1224|Proteobacteria,2UUQN@28211|Alphaproteobacteria,3N90V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3885052_3	582899.Hden_2336	4.015e-56	207.0	COG0071@1|root,COG0071@2|Bacteria,1R9Y1@1224|Proteobacteria,2UA1J@28211|Alphaproteobacteria,3N75E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	hspH	-	-	ko:K04080	-	-	-	-	ko00000,ko03110	-	-	-	HSP20
TLS2_k127_3885052_5	1267005.KB911257_gene854	3.08e-24	106.0	COG5568@1|root,COG5568@2|Bacteria,1N9BT@1224|Proteobacteria,2UFNF@28211|Alphaproteobacteria,3N96H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1150)	MA20_24245	-	-	-	-	-	-	-	-	-	-	-	DUF1150
TLS2_k127_3885052_0	1267005.KB911257_gene1166	1.976e-174	556.0	COG1679@1|root,COG1679@2|Bacteria,1NFH4@1224|Proteobacteria,2TTR6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
TLS2_k127_3885052_4	467661.RKLH11_3971	1.11e-43	175.0	COG1786@1|root,COG1786@2|Bacteria,1RFUH@1224|Proteobacteria,2USWD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
TLS2_k127_3885052_1	1112212.JH584235_gene3224	3.721e-83	279.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TRE4@28211|Alphaproteobacteria,2K22C@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,N6_N4_Mtase
TLS2_k127_3885052_6	745776.DGo_CA2004	1.426e-22	98.0	COG2189@1|root,COG2189@2|Bacteria,1WN0J@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	DNA methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
TLS2_k127_3921455_3	631454.N177_2961	1.299e-102	340.0	COG0491@1|root,COG0491@2|Bacteria,1R9ID@1224|Proteobacteria	1224|Proteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_3921455_2	1380394.JADL01000009_gene3410	6.538e-143	466.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TVPQ@28211|Alphaproteobacteria,2JVIG@204441|Rhodospirillales	204441|Rhodospirillales	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_3921455_0	1267005.KB911264_gene3189	4e-209	672.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,3N86I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Extracellular solute-binding protein	nikA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_3921455_4	670307.HYPDE_30173	1.181e-78	275.0	COG5342@1|root,COG5342@2|Bacteria,1MV8Y@1224|Proteobacteria,2TS6A@28211|Alphaproteobacteria,3N7DB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Invasion associated locus B (IalB) protein	MA20_13025	-	-	-	-	-	-	-	-	-	-	-	IalB
TLS2_k127_3921455_1	717785.HYPMC_0926	6.538e-188	591.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2TRAD@28211|Alphaproteobacteria,3N6AY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
TLS2_k127_3921455_6	1267005.KB911256_gene1451	5.56e-54	193.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2TT6Q@28211|Alphaproteobacteria,3N6TR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
TLS2_k127_3922066_16	717785.HYPMC_2574	2.504e-42	156.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2TRUT@28211|Alphaproteobacteria,3N6MM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
TLS2_k127_3922066_18	1122962.AULH01000006_gene3157	4.456e-37	147.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2UBQ1@28211|Alphaproteobacteria,36YNA@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Ribosomal protein L23	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
TLS2_k127_3922066_1	1267005.KB911261_gene2238	4.093e-146	466.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2TTKD@28211|Alphaproteobacteria,3N6HR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
TLS2_k127_3922066_15	622637.KE124774_gene3181	6.877e-47	178.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2U95S@28211|Alphaproteobacteria,36YAG@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Ribosomal protein S19	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
TLS2_k127_3922066_12	648885.KB316283_gene3379	7.03e-52	188.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2U96X@28211|Alphaproteobacteria,1JUU7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
TLS2_k127_3922066_2	670307.HYPDE_32628	7.404e-120	396.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2TRZ2@28211|Alphaproteobacteria,3N6KN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
TLS2_k127_3922066_8	1267005.KB911261_gene2234	1.279e-68	234.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2U710@28211|Alphaproteobacteria,3N6UX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
TLS2_k127_3922066_21	717785.HYPMC_2567	2.559e-18	87.0	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2UF59@28211|Alphaproteobacteria,3N7CX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
TLS2_k127_3922066_19	1267005.KB911261_gene2232	1.239e-31	128.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2UBRF@28211|Alphaproteobacteria,3N78R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
TLS2_k127_3922066_10	582899.Hden_1027	1.101e-65	226.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2U743@28211|Alphaproteobacteria,3N6TX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
TLS2_k127_3922066_13	1267005.KB911261_gene2230	2.786e-50	182.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2UC6Y@28211|Alphaproteobacteria,3N73B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
TLS2_k127_3922066_3	670307.HYPDE_32598	9.021e-94	312.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2TQPF@28211|Alphaproteobacteria,3N6HT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
TLS2_k127_3922066_17	1267005.KB911261_gene2228	7.621e-40	152.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2UC01@28211|Alphaproteobacteria,3N73V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
TLS2_k127_3922066_11	1267005.KB911261_gene2227	2.957e-62	220.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2U6ZH@28211|Alphaproteobacteria,3N6Y3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
TLS2_k127_3922066_7	1267005.KB911261_gene2226	5.805e-73	249.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2TV09@28211|Alphaproteobacteria,3N6UR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
TLS2_k127_3922066_14	1267005.KB911261_gene2225	3.903e-47	171.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2U9A6@28211|Alphaproteobacteria,3N6ZG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
TLS2_k127_3922066_6	402881.Plav_2753	2.53e-85	286.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2TSRI@28211|Alphaproteobacteria,1JN3H@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Belongs to the universal ribosomal protein uS5 family	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
TLS2_k127_3922066_20	411684.HPDFL43_06727	4.305e-23	101.0	COG1841@1|root,COG1841@2|Bacteria,1PU2S@1224|Proteobacteria,2UF55@28211|Alphaproteobacteria,43M7Z@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Ribosomal protein L30	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
TLS2_k127_3922066_9	1267005.KB911261_gene2222	8.731e-66	229.0	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,2U79D@28211|Alphaproteobacteria,3N6ZC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
TLS2_k127_3922066_0	1267005.KB911261_gene2221	1.219e-240	749.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria,3N6EX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
TLS2_k127_3922066_5	1207063.P24_12876	2.239e-88	297.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria,2JPCK@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
TLS2_k127_3922066_4	717785.HYPMC_2546	4.897e-92	311.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TS6B@28211|Alphaproteobacteria,3N6F9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S1C family	htrA2	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_3930834_4	492774.JQMB01000005_gene5239	9.977e-120	389.0	COG0665@1|root,COG0665@2|Bacteria,1R7JH@1224|Proteobacteria,2U1VP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS2_k127_3930834_1	1411123.JQNH01000001_gene385	3.866e-200	633.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,2TUDG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_3930834_0	935261.JAGL01000029_gene342	6.99e-212	672.0	COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,2TT7F@28211|Alphaproteobacteria,43IWA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_3930834_3	1120792.JAFV01000001_gene2044	1.02e-137	448.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,36XD7@31993|Methylocystaceae	28211|Alphaproteobacteria	E	TOBE domain	-	-	3.6.3.30	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	M00190,M00193	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11	-	-	ABC_tran,TOBE_2
TLS2_k127_3930834_2	1411123.JQNH01000001_gene389	9.337e-170	541.0	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,2TRY8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type Fe3 transport system, periplasmic component	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
TLS2_k127_3930834_7	670307.HYPDE_34718	1.734e-11	73.0	2DS8Z@1|root,33F1X@2|Bacteria,1N095@1224|Proteobacteria,2UCJ3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_36060	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3930834_6	582402.Hbal_1425	1.517e-28	115.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,43YF2@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Cold-shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_3930834_5	1267005.KB911258_gene114	1.807e-112	372.0	2FBW8@1|root,3440T@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_39484_2	426355.Mrad2831_5983	1.912e-181	585.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,1JQSM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_39484_5	1121106.JQKB01000010_gene443	2.624e-43	168.0	COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,2TSWB@28211|Alphaproteobacteria,2JYQE@204441|Rhodospirillales	204441|Rhodospirillales	Q	2-keto-4-pentenoate hydratase	-	-	4.2.1.80	ko:K02554	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R02601,R04781	RC00750,RC01213	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
TLS2_k127_39484_4	177437.HRM2_p00730	6.491e-57	211.0	COG0272@1|root,COG0847@1|root,COG0272@2|Bacteria,COG0847@2|Bacteria,1R7J9@1224|Proteobacteria,43AFT@68525|delta/epsilon subdivisions,2X5VP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	EXOIII	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
TLS2_k127_39484_3	1267005.KB911259_gene3833	6.085e-103	345.0	2CKRE@1|root,32SCW@2|Bacteria,1MWRU@1224|Proteobacteria,2TSRM@28211|Alphaproteobacteria,3N7FK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2865)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2865
TLS2_k127_39484_7	546267.NEIPOLOT_01423	5.648e-06	56.0	COG0454@1|root,COG0456@2|Bacteria,1N9SQ@1224|Proteobacteria,2VR26@28216|Betaproteobacteria,2KR51@206351|Neisseriales	206351|Neisseriales	K	Acetyltransferase, GNAT family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
TLS2_k127_39484_1	582899.Hden_1839	5.946e-194	615.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRCI@28211|Alphaproteobacteria,3N6JF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX1	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS2_k127_39484_0	1267005.KB911261_gene2253	5.889e-272	847.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2TRAU@28211|Alphaproteobacteria,3N69B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
TLS2_k127_39484_6	1267005.KB911257_gene929	1.978e-16	81.0	COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,2U33F@28211|Alphaproteobacteria,3N73Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1223)	MA20_43790	-	-	-	-	-	-	-	-	-	-	-	DUF1223
TLS2_k127_3957432_1	935557.ATYB01000014_gene2479	1.975e-231	732.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2TRCR@28211|Alphaproteobacteria,4B7B6@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Sulfite reductase	cysI	-	1.8.1.2	ko:K00381	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
TLS2_k127_3957432_15	1122132.AQYH01000001_gene830	6.531e-07	55.0	2EG12@1|root,339T3@2|Bacteria,1NGID@1224|Proteobacteria,2UK0A@28211|Alphaproteobacteria,4BFJ5@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2849)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2849
TLS2_k127_3957432_5	551789.ATVJ01000003_gene342	4.709e-95	332.0	COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,2TRJC@28211|Alphaproteobacteria,43X97@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
TLS2_k127_3957432_12	856793.MICA_366	5.336e-22	100.0	COG0633@1|root,COG0633@2|Bacteria,1N261@1224|Proteobacteria,2UC7B@28211|Alphaproteobacteria,4BQVH@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	fdx	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
TLS2_k127_3957432_3	582899.Hden_3121	8.033e-148	488.0	COG1368@1|root,COG1368@2|Bacteria,1MXT1@1224|Proteobacteria,2TVM8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Sulfatase	MA20_02375	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_3957432_11	1282876.BAOK01000001_gene960	3.837e-49	188.0	COG1597@1|root,COG1597@2|Bacteria,1RIPU@1224|Proteobacteria,2TVUD@28211|Alphaproteobacteria,4BQTY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS2_k127_3957432_4	1121106.JQKB01000011_gene303	1.213e-108	366.0	COG0477@1|root,COG2814@2|Bacteria,1MW1P@1224|Proteobacteria	1224|Proteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_3957432_13	1120983.KB894572_gene3146	6.615e-13	76.0	29ISC@1|root,2Z7VE@2|Bacteria,1MWUK@1224|Proteobacteria,2TTFU@28211|Alphaproteobacteria,1JPZS@119043|Rhodobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
TLS2_k127_3957432_14	1121440.AUMA01000005_gene2586	3.524e-12	75.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,42M32@68525|delta/epsilon subdivisions,2WJA4@28221|Deltaproteobacteria,2M7RC@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
TLS2_k127_3957432_9	663610.JQKO01000010_gene2271	1.81e-78	273.0	COG3058@1|root,COG3058@2|Bacteria,1NK06@1224|Proteobacteria,2U11R@28211|Alphaproteobacteria,3NBCQ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	Protein involved in formate dehydrogenase formation	fdhE	-	-	ko:K02380	-	-	-	-	ko00000	-	-	-	FdhE
TLS2_k127_3957432_8	991905.SL003B_1281	1.246e-84	293.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2TT30@28211|Alphaproteobacteria,4BT0Y@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Prokaryotic cytochrome b561	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
TLS2_k127_3957432_2	883080.HMPREF9697_03736	1.28e-173	555.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2TTE2@28211|Alphaproteobacteria,3JVZ2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Formate dehydrogenase N, transmembrane	fdxH	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_7,Form-deh_trans
TLS2_k127_3957432_0	883080.HMPREF9697_03735	0.0	1405.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2TTPX@28211|Alphaproteobacteria,3JVN3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
TLS2_k127_3957432_7	666684.AfiDRAFT_0294	3.743e-90	301.0	COG0243@1|root,COG0243@2|Bacteria,1MWPS@1224|Proteobacteria,2TVFQ@28211|Alphaproteobacteria,3JWIA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin
TLS2_k127_3957432_6	438753.AZC_1079	3.553e-94	318.0	COG0583@1|root,COG0583@2|Bacteria,1N4P5@1224|Proteobacteria,2TQYX@28211|Alphaproteobacteria,3EXXC@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	oxyS	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_3957432_10	1408419.JHYG01000013_gene2109	2.451e-69	258.0	COG0834@1|root,COG0834@2|Bacteria,1QQXM@1224|Proteobacteria,2U599@28211|Alphaproteobacteria,2JRY2@204441|Rhodospirillales	204441|Rhodospirillales	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
TLS2_k127_3960843_2	1267005.KB911257_gene996	2.755e-131	426.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria,3N7ZS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Alcohol dehydrogenase zinc-binding	MA20_25320	-	1.1.1.1,1.6.5.5	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_3960843_8	582899.Hden_3263	1.289e-77	266.0	COG0566@1|root,COG0566@2|Bacteria,1REIN@1224|Proteobacteria,2U76Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	rrna methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
TLS2_k127_3960843_13	1267005.KB911257_gene998	5.787e-36	144.0	COG5342@1|root,COG5342@2|Bacteria,1R46Z@1224|Proteobacteria,2VGJG@28211|Alphaproteobacteria,3N9I5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	invasion associated locus B	-	-	-	-	-	-	-	-	-	-	-	-	IalB
TLS2_k127_3960843_10	1267005.KB911257_gene935	1.786e-65	232.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2TSEW@28211|Alphaproteobacteria,3N6ZX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CO	Periplasmic protein thiol disulfide oxidoreductase	ccmG	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_3960843_15	670307.HYPDE_39578	6.155e-14	73.0	2EIRC@1|root,33CGS@2|Bacteria,1NGFG@1224|Proteobacteria,2UJFR@28211|Alphaproteobacteria,3N7GA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	-	-	-	ko:K02196	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.107	-	-	CcmD
TLS2_k127_3960843_6	670307.HYPDE_39583	8.903e-105	345.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2TSW8@28211|Alphaproteobacteria,3N6MK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
TLS2_k127_3960843_9	1267005.KB911255_gene2985	5.542e-70	258.0	COG5523@1|root,COG5523@2|Bacteria	2|Bacteria	T	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,DUF975
TLS2_k127_3960843_11	690597.JH730982_gene1975	2.299e-46	171.0	COG2128@1|root,COG2128@2|Bacteria,1RD2I@1224|Proteobacteria	1224|Proteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_3960843_12	1366046.HIMB11_01608	4.025e-39	154.0	2E474@1|root,32Z30@2|Bacteria,1NGK4@1224|Proteobacteria,2UKT6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3960843_3	1038859.AXAU01000001_gene3083	1.431e-129	421.0	COG3618@1|root,COG3618@2|Bacteria,1QWWJ@1224|Proteobacteria,2TV8V@28211|Alphaproteobacteria,3JTX0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_3960843_5	466038.KI421440_gene254	4.179e-111	369.0	COG4336@1|root,COG4336@2|Bacteria,1MW52@1224|Proteobacteria,2TST8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the D-glutamate cyclase family	MA20_16485	-	-	-	-	-	-	-	-	-	-	-	DUF1445
TLS2_k127_3960843_7	388739.RSK20926_00180	2.443e-89	306.0	COG1638@1|root,COG1638@2|Bacteria,1MUBS@1224|Proteobacteria,2TUKV@28211|Alphaproteobacteria,2P4GY@2433|Roseobacter	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_3960843_14	290400.Jann_2568	1.126e-15	86.0	COG3090@1|root,COG3090@2|Bacteria,1QU8D@1224|Proteobacteria,2TWD9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG4665 TRAP-type mannitol chloroaromatic compound transport system small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_3960843_1	411684.HPDFL43_09902	1.385e-165	541.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,43IXP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_3960843_0	1188256.BASI01000001_gene1433	0.0	1631.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,3FDT9@34008|Rhodovulum	28211|Alphaproteobacteria	EQ	Hydantoinase B/oxoprolinase	oplaH	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
TLS2_k127_3960843_4	717785.HYPMC_0978	3.564e-114	375.0	COG0583@1|root,COG0583@2|Bacteria,1N4P5@1224|Proteobacteria,2TQYX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_3985865_9	314278.NB231_07287	2.355e-24	120.0	COG4976@1|root,COG4976@2|Bacteria,1QYTJ@1224|Proteobacteria	1224|Proteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
TLS2_k127_3985865_4	670307.HYPDE_39938	1.355e-115	380.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2TUF2@28211|Alphaproteobacteria,3N6B1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
TLS2_k127_3985865_1	1123501.KB902293_gene3495	2.613e-167	536.0	COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,2TRYD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	MiaB-like tRNA modifying enzyme	mtaB	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
TLS2_k127_3985865_2	717785.HYPMC_4625	1.023e-142	467.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2TS0M@28211|Alphaproteobacteria,3N6ED@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
TLS2_k127_3985865_5	1267005.KB911257_gene1032	1.402e-62	221.0	COG2917@1|root,COG2917@2|Bacteria	2|Bacteria	D	probably involved in intracellular septation	ispZ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
TLS2_k127_3985865_6	196490.AUEZ01000026_gene1852	2.401e-49	184.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2U74X@28211|Alphaproteobacteria,3JU97@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	D	probably involved in intracellular septation	ispZ	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
TLS2_k127_3985865_7	717785.HYPMC_4628	1.864e-47	176.0	COG1846@1|root,COG1846@2|Bacteria,1RJRY@1224|Proteobacteria,2UA4D@28211|Alphaproteobacteria,3N8VY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_3985865_0	670307.HYPDE_39968	3.716e-185	584.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria,3N64Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_3985865_8	936455.KI421499_gene6238	6.933e-38	148.0	COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2UBTA@28211|Alphaproteobacteria,3JY8M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1178)	MA20_39715	-	-	-	-	-	-	-	-	-	-	-	DUF1178
TLS2_k127_3985865_10	1219035.NT2_13_00710	0.0008002	42.0	COG1961@1|root,COG1961@2|Bacteria,1PWCY@1224|Proteobacteria,2TVME@28211|Alphaproteobacteria,2K9C3@204457|Sphingomonadales	204457|Sphingomonadales	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_3985865_3	1121106.JQKB01000018_gene4924	3.965e-129	418.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2VGYC@28211|Alphaproteobacteria,2JVCW@204441|Rhodospirillales	28211|Alphaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
TLS2_k127_3989767_0	301.JNHE01000012_gene1469	1.807e-98	336.0	COG2199@1|root,COG3706@2|Bacteria,1MZQ8@1224|Proteobacteria,1RZJU@1236|Gammaproteobacteria,1YHR1@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
TLS2_k127_3989767_2	301.JNHE01000012_gene1469	4.819e-66	246.0	COG2199@1|root,COG3706@2|Bacteria,1MZQ8@1224|Proteobacteria,1RZJU@1236|Gammaproteobacteria,1YHR1@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
TLS2_k127_3989767_4	1411123.JQNH01000001_gene2362	4.605e-54	198.0	COG0664@1|root,COG0664@2|Bacteria,1Q93V@1224|Proteobacteria,2TTEY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	cyclic nucleotide-binding	MA20_09210	-	-	-	-	-	-	-	-	-	-	-	Imp-YgjV,cNMP_binding
TLS2_k127_3989767_3	1000565.METUNv1_02980	3.886e-61	230.0	COG4249@1|root,COG4249@2|Bacteria,1QU7W@1224|Proteobacteria,2VITZ@28216|Betaproteobacteria,2KVSF@206389|Rhodocyclales	206389|Rhodocyclales	S	Peptidase C13 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C13
TLS2_k127_3989767_7	1297570.MESS4_510155	2.593e-05	48.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_3989767_5	717785.HYPMC_4410	4.75e-33	132.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2UBQU@28211|Alphaproteobacteria,3N72U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
TLS2_k127_3989767_1	1267005.KB911259_gene3899	4.843e-87	304.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,3N70G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
TLS2_k127_3989767_6	582899.Hden_2449	4.09e-25	108.0	COG0352@1|root,COG0352@2|Bacteria,1MV42@1224|Proteobacteria,2TSSA@28211|Alphaproteobacteria,3N7CC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Thiamine monophosphate synthase	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TLS2_k127_4009915_2	316057.RPD_3528	2.022e-54	199.0	COG0791@1|root,COG0791@2|Bacteria,1MW03@1224|Proteobacteria,2TSFG@28211|Alphaproteobacteria,3JQZJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,SH3_3
TLS2_k127_4009915_0	670307.HYPDE_24153	5.686e-161	521.0	COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria,3N6E2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the peptidase M17 family	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17
TLS2_k127_4009915_3	717785.HYPMC_0947	1.407e-41	158.0	COG0216@1|root,COG0216@2|Bacteria,1R348@1224|Proteobacteria,2TZXT@28211|Alphaproteobacteria,3N9DR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
TLS2_k127_4009915_1	670307.HYPDE_28668	4.721e-147	468.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,3N65Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_4016627_17	1267005.KB911257_gene845	3.028e-84	289.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TSTS@28211|Alphaproteobacteria,3N73F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	sfuB	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
TLS2_k127_4016627_4	504832.OCAR_6286	3.505e-166	530.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRSS@28211|Alphaproteobacteria,3JS9V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS2_k127_4016627_19	384765.SIAM614_07378	8.115e-48	174.0	COG0662@1|root,COG0662@2|Bacteria,1RHWU@1224|Proteobacteria,2UBF8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_4016627_1	288000.BBta_4462	8.341e-192	608.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRMR@28211|Alphaproteobacteria,3JQYJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,Transket_pyr,Transketolase_C
TLS2_k127_4016627_7	1304877.KI519399_gene5072	4.457e-159	514.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TRXM@28211|Alphaproteobacteria,3JRK6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	1.2.4.1,2.3.1.12	ko:K00162,ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R02569,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_4016627_2	288000.BBta_0544	3.073e-180	571.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,3JRRY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class-V	MA20_39235	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TLS2_k127_4016627_6	582899.Hden_0845	1.841e-161	517.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2TR9V@28211|Alphaproteobacteria,3N6BN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS2_k127_4016627_18	331869.BAL199_15092	2.233e-68	238.0	COG0625@1|root,COG0625@2|Bacteria,1RA05@1224|Proteobacteria,2TS58@28211|Alphaproteobacteria,4BS5Z@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Glutathione S-transferase, N-terminal domain	gst1	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
TLS2_k127_4016627_14	883078.HMPREF9695_01399	1.359e-119	393.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2TSUU@28211|Alphaproteobacteria,3JVGJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	MA20_04115	-	1.1.1.79,1.1.1.81	ko:K12972	ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R01388,R01392,R02527	RC00031,RC00042,RC00670	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh_C
TLS2_k127_4016627_5	670307.HYPDE_39023	1.407e-165	530.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2TVZH@28211|Alphaproteobacteria,3N81A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Transporter associated domain	corB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_4016627_15	472759.Nhal_3785	2.649e-114	379.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,1RNYX@1236|Gammaproteobacteria,1X0GH@135613|Chromatiales	135613|Chromatiales	E	Beta-eliminating lyase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_4016627_3	331869.BAL199_03119	1.135e-170	543.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,4BPJW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	MA20_43260	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS2_k127_4016627_16	1205680.CAKO01000002_gene3018	6.883e-95	318.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.1.1.41,4.2.1.17	ko:K01692,ko:K11264	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R00923,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00097,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_4016627_13	1267005.KB911257_gene991	1.029e-124	405.0	COG1192@1|root,COG1192@2|Bacteria	2|Bacteria	D	plasmid maintenance	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA,Mrr_cat
TLS2_k127_4016627_8	670307.HYPDE_37888	1.184e-153	494.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria,3N66R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_4016627_10	402881.Plav_1646	3.77e-130	426.0	COG2141@1|root,COG2141@2|Bacteria,1PFU1@1224|Proteobacteria,2VA1B@28211|Alphaproteobacteria,1JQ6W@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	1.14.13.107	ko:K14733	ko00903,map00903	-	R06398,R09385,R09389,R09393	RC01506	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
TLS2_k127_4016627_12	991905.SL003B_2616	7.923e-125	411.0	COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2TU6K@28211|Alphaproteobacteria,4BP7G@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS2_k127_4016627_20	991905.SL003B_2028	2.42e-36	149.0	COG2370@1|root,COG2370@2|Bacteria,1Q63I@1224|Proteobacteria,2UB26@28211|Alphaproteobacteria,4BQNU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	HupE / UreJ protein	-	-	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
TLS2_k127_4016627_22	331869.BAL199_29972	1.043e-26	122.0	COG3255@1|root,COG3255@2|Bacteria,1RM64@1224|Proteobacteria,2U7YK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4016627_9	1205680.CAKO01000006_gene3246	2.973e-138	443.0	COG0596@1|root,COG0596@2|Bacteria,1NUT9@1224|Proteobacteria,2TVMS@28211|Alphaproteobacteria,2JVBP@204441|Rhodospirillales	204441|Rhodospirillales	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_4016627_11	1211115.ALIQ01000028_gene740	2.746e-128	414.0	COG1878@1|root,COG1878@2|Bacteria,1MV8S@1224|Proteobacteria,2TSUJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM cyclase family protein	MA20_38045	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_4016627_21	582899.Hden_1780	1.519e-33	140.0	2CPI3@1|root,32SJ7@2|Bacteria,1N1IR@1224|Proteobacteria,2UBVS@28211|Alphaproteobacteria,3N92F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF992
TLS2_k127_4016627_0	1123504.JQKD01000098_gene2964	3.486e-192	614.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VI39@28216|Betaproteobacteria,4AJ2P@80864|Comamonadaceae	28216|Betaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_4081551_1	670307.HYPDE_30828	1.263e-53	195.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,3N661@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TLS2_k127_4081551_2	314254.OA2633_13155	1.22e-11	66.0	COG3847@1|root,COG3847@2|Bacteria,1NGVU@1224|Proteobacteria,2UJE8@28211|Alphaproteobacteria,43YY0@69657|Hyphomonadaceae	28211|Alphaproteobacteria	U	Flp/Fap pilin component	MA20_03885	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
TLS2_k127_4081551_0	1038867.AXAY01000007_gene5966	4.305e-261	814.0	COG0028@1|root,COG0028@2|Bacteria,1MWC3@1224|Proteobacteria,2TTA2@28211|Alphaproteobacteria,3JS9T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	MA20_15555	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_4085078_2	331869.BAL199_03234	3.709e-27	111.0	COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,2TTWF@28211|Alphaproteobacteria,4BR7P@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
TLS2_k127_4085078_1	314231.FP2506_17504	3.87e-47	185.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TRZE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
TLS2_k127_4085078_3	1408254.T458_27670	1.246e-17	89.0	COG3090@1|root,COG3090@2|Bacteria,1VFA6@1239|Firmicutes,4HNAC@91061|Bacilli,26XCK@186822|Paenibacillaceae	91061|Bacilli	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_4085078_0	314231.FP2506_17514	2.713e-105	356.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2PKD4@255475|Aurantimonadaceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_4091246_0	1267005.KB911257_gene1054	4.984e-317	981.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,3N6GV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
TLS2_k127_4091246_5	1267005.KB911257_gene1052	3.566e-84	287.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2TR5Z@28211|Alphaproteobacteria,3N6QV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	MA20_24865	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
TLS2_k127_4091246_1	1267005.KB911256_gene1825	6.704e-230	717.0	COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,2TRRQ@28211|Alphaproteobacteria,3N7UK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Saccharopine dehydrogenase C-terminal domain	lys1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
TLS2_k127_4091246_8	1429916.X566_21090	8.313e-53	190.0	COG3576@1|root,COG3576@2|Bacteria,1N1V1@1224|Proteobacteria,2UEXF@28211|Alphaproteobacteria,3K5BT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
TLS2_k127_4091246_10	316057.RPD_2766	1.481e-39	151.0	COG2050@1|root,COG2050@2|Bacteria,1NA0B@1224|Proteobacteria,2UI6H@28211|Alphaproteobacteria,3K425@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_4091246_12	582899.Hden_2564	4.282e-17	89.0	2FCZI@1|root,34525@2|Bacteria,1Q4YH@1224|Proteobacteria,2VBD1@28211|Alphaproteobacteria,3N921@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4091246_9	717785.HYPMC_0984	3.636e-51	188.0	COG5317@1|root,COG5317@2|Bacteria,1RJIA@1224|Proteobacteria,2U9ID@28211|Alphaproteobacteria,3N766@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1465)	MA20_18080	-	-	ko:K13592	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	DUF1465
TLS2_k127_4091246_3	1287116.X734_29705	7.785e-91	311.0	COG2423@1|root,COG2423@2|Bacteria	2|Bacteria	E	ornithine cyclodeaminase activity	-	-	1.4.1.1,1.5.1.25,4.3.1.12	ko:K01750,ko:K18258,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000,ko04147	-	-	-	OCD_Mu_crystall
TLS2_k127_4091246_2	709797.CSIRO_0254	2.95e-201	634.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,3JRVX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.18	ko:K00822	ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100	-	R00907,R04187	RC00008,RC00062,RC00160	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_4091246_4	1333998.M2A_1335	6.631e-86	295.0	COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,2TSEU@28211|Alphaproteobacteria,4BQFK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	haloacid dehalogenase-like hydrolase	serB	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
TLS2_k127_4091246_6	717785.HYPMC_0938	2.206e-82	282.0	COG5465@1|root,COG5465@2|Bacteria,1REC1@1224|Proteobacteria,2U7UP@28211|Alphaproteobacteria,3N6S4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative bacterial sensory transduction regulator	MA20_05485	-	-	-	-	-	-	-	-	-	-	-	YbjN
TLS2_k127_4091246_11	1267005.KB911256_gene1492	3.138e-22	98.0	COG2960@1|root,COG2960@2|Bacteria,1N725@1224|Proteobacteria,2UFEP@28211|Alphaproteobacteria,3N7EF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Membrane fusogenic activity	MA20_05375	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
TLS2_k127_4091246_7	1267005.KB911255_gene2686	3.268e-56	198.0	COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,2U735@28211|Alphaproteobacteria,3N8WI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_412403_9	1245469.S58_65480	1.759e-45	173.0	COG1917@1|root,COG1917@2|Bacteria,1RGXQ@1224|Proteobacteria,2U7IF@28211|Alphaproteobacteria,3JYR5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel domain protein	MA20_27600	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_412403_0	717785.HYPMC_2125	7.4e-323	994.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria,3N6EJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ABC transporter	chvD	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_Xtn
TLS2_k127_412403_5	717785.HYPMC_0318	3.572e-82	286.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2TSW3@28211|Alphaproteobacteria,3N7HW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD	amiD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	2.5.1.3,3.5.1.28	ko:K00788,ko:K01447,ko:K03806	ko00730,ko01100,map00730,map01100	M00127	R03223,R04112,R10712	RC00064,RC00141,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Amidase_2,PG_binding_1
TLS2_k127_412403_7	1502851.FG93_01519	2.344e-57	207.0	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,2TTX1@28211|Alphaproteobacteria,3K2YX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Tellurite resistance protein TerB	djlA	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
TLS2_k127_412403_2	670307.HYPDE_23803	1.193e-227	721.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TQXN@28211|Alphaproteobacteria,3N6BW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Creatinase/Prolidase N-terminal domain	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
TLS2_k127_412403_1	331869.BAL199_02734	3.191e-235	742.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_412403_4	1207063.P24_10011	6.503e-88	298.0	COG4221@1|root,COG4221@2|Bacteria,1MWXS@1224|Proteobacteria,2TQYY@28211|Alphaproteobacteria,2JRNC@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_412403_6	648757.Rvan_3297	1.4e-72	262.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2TRK1@28211|Alphaproteobacteria,3N6ZQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
TLS2_k127_412403_8	441620.Mpop_3553	3.373e-54	201.0	COG3427@1|root,COG3427@2|Bacteria,1RHUC@1224|Proteobacteria,2U9HD@28211|Alphaproteobacteria,1JV22@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	carbon monoxide dehydrogenase subunit G	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
TLS2_k127_412403_10	1123504.JQKD01000007_gene3511	3.031e-39	156.0	COG0406@1|root,COG0406@2|Bacteria,1N83T@1224|Proteobacteria,2VY3M@28216|Betaproteobacteria,4AG7M@80864|Comamonadaceae	28216|Betaproteobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
TLS2_k127_412403_3	1205680.CAKO01000002_gene3061	9.477e-131	422.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the thiolase family	MA20_18575	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_4174054_9	717785.HYPMC_1905	5.94e-81	276.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2TUKR@28211|Alphaproteobacteria,3N80F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
TLS2_k127_4174054_8	670307.HYPDE_30003	1.49e-100	336.0	COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria,3N6UN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	cytochrome c biogenesis protein	soxV	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
TLS2_k127_4174054_3	1238182.C882_2042	5.472e-222	703.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2TUAE@28211|Alphaproteobacteria,2JQ8D@204441|Rhodospirillales	204441|Rhodospirillales	F	Belongs to the 5'-nucleotidase family	-	-	-	ko:K17224	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	5_nucleotid_C
TLS2_k127_4174054_10	1411123.JQNH01000001_gene3747	2.708e-71	248.0	COG2010@1|root,COG2010@2|Bacteria,1P1GY@1224|Proteobacteria,2U1EG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c	soxX	-	-	ko:K17223	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C,Cytochrome_CBB3
TLS2_k127_4174054_6	1411123.JQNH01000001_gene3748	4.918e-116	383.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2TTDW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	soxA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005507,GO:0005515,GO:0005575,GO:0005623,GO:0006091,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0016667,GO:0016669,GO:0016740,GO:0016782,GO:0016783,GO:0018192,GO:0018193,GO:0018198,GO:0018307,GO:0019417,GO:0019538,GO:0020037,GO:0022900,GO:0036211,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0046982,GO:0046983,GO:0048037,GO:0055114,GO:0071704,GO:0097159,GO:0098822,GO:1901363,GO:1901564	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
TLS2_k127_4174054_7	717785.HYPMC_1472	2.048e-112	373.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2TTQ2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Rod shape-determining protein (MreB)	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TLS2_k127_4174054_2	648757.Rvan_1678	1.419e-241	756.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria,3N660@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS2_k127_4174054_12	717785.HYPMC_1015	5.078e-66	230.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2U758@28211|Alphaproteobacteria,3N70J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
TLS2_k127_4174054_14	391600.ABRU01000011_gene3341	6.459e-16	91.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2U758@28211|Alphaproteobacteria,2KGKV@204458|Caulobacterales	204458|Caulobacterales	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
TLS2_k127_4174054_11	670307.HYPDE_35683	6.472e-68	244.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2U6ZQ@28211|Alphaproteobacteria,3N77B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
TLS2_k127_4174054_5	1267005.KB911256_gene1479	1.936e-183	595.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,3N63C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Penicillin-binding protein, 1A family	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS2_k127_4174054_15	670307.HYPDE_33868	0.0002378	45.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,3N68D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_4174054_4	1380394.JADL01000005_gene5555	6.717e-214	680.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,2JRI6@204441|Rhodospirillales	204441|Rhodospirillales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_4174054_1	1267005.KB911258_gene320	0.0	1129.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,3N7IJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Malic enzyme, NAD binding domain	tme	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
TLS2_k127_4174054_0	1267005.KB911257_gene986	0.0	1190.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,3N6KE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
TLS2_k127_4174054_13	717785.HYPMC_4785	5.011e-39	151.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,3N6A4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
TLS2_k127_4237814_1	1267005.KB911259_gene3839	5.989e-118	384.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2TQVM@28211|Alphaproteobacteria,3N7T4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class I and II	dapL	-	2.6.1.17	ko:K14261,ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_4237814_0	991905.SL003B_0142	5.424e-229	736.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2TR48@28211|Alphaproteobacteria,4BPI4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	DNA segregation ATPase FtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TLS2_k127_4237814_2	622637.KE124774_gene1644	5.965e-54	194.0	COG1225@1|root,COG1225@2|Bacteria,1RHSM@1224|Proteobacteria,2U9FF@28211|Alphaproteobacteria,36ZQ3@31993|Methylocystaceae	28211|Alphaproteobacteria	O	Redoxin	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
TLS2_k127_4237814_3	670307.HYPDE_40008	1.239e-35	141.0	COG5490@1|root,COG5490@2|Bacteria	2|Bacteria	S	Phasin protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
TLS2_k127_4256529_12	1270193.JARP01000005_gene3828	5.802e-17	83.0	COG2972@1|root,COG2972@2|Bacteria,4NST1@976|Bacteroidetes,1I5GP@117743|Flavobacteriia,2NXAF@237|Flavobacterium	976|Bacteroidetes	T	2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	2TM
TLS2_k127_4256529_4	1380355.JNIJ01000029_gene3140	9.297e-120	391.0	COG0451@1|root,COG0451@2|Bacteria,1MWYB@1224|Proteobacteria,2TSDE@28211|Alphaproteobacteria,3JY3E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_4256529_5	1121106.JQKB01000137_gene4371	1.142e-105	353.0	COG1028@1|root,COG1028@2|Bacteria,1PEWK@1224|Proteobacteria,2TV4E@28211|Alphaproteobacteria,2JV22@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_4256529_0	1121861.KB899919_gene2750	4.7e-207	658.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria,2JPPG@204441|Rhodospirillales	204441|Rhodospirillales	EH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_4256529_7	1205680.CAKO01000040_gene796	1.185e-99	333.0	COG0346@1|root,COG0346@2|Bacteria,1MZT5@1224|Proteobacteria,2U4GS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
TLS2_k127_4256529_1	1205680.CAKO01000002_gene3017	5.624e-201	631.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales	204441|Rhodospirillales	C	III protein, CoA-transferase family	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_4256529_8	1235457.C404_24895	3.637e-82	283.0	COG0697@1|root,COG0697@2|Bacteria,1P38S@1224|Proteobacteria,2VJFZ@28216|Betaproteobacteria,1K7H2@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_4256529_9	189753.AXAS01000013_gene5789	4.16e-73	261.0	COG0412@1|root,COG0412@2|Bacteria,1R3DI@1224|Proteobacteria,2TVEH@28211|Alphaproteobacteria,3JXJM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS2_k127_4256529_11	1267005.KB911260_gene3488	4.098e-28	129.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	plpD	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA,SmpA_OmlA
TLS2_k127_4256529_6	160492.XF_1804	3.423e-104	347.0	COG0338@1|root,COG0338@2|Bacteria,1QFT0@1224|Proteobacteria,1TD34@1236|Gammaproteobacteria,1XA0T@135614|Xanthomonadales	135614|Xanthomonadales	L	D12 class N6 adenine-specific DNA methyltransferase	-	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
TLS2_k127_4256529_2	196490.AUEZ01000062_gene1561	1.389e-150	487.0	COG2141@1|root,COG2141@2|Bacteria,1MVMB@1224|Proteobacteria,2U1EV@28211|Alphaproteobacteria,3JW4H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_4256529_10	876269.ARWA01000001_gene1233	1.289e-45	170.0	2CYEB@1|root,32T42@2|Bacteria,1MVVN@1224|Proteobacteria,2U2YY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4256529_3	670307.HYPDE_34248	2.421e-147	473.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
TLS2_k127_4264111_4	1038859.AXAU01000007_gene5806	1.79e-94	314.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2UD1C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_4264111_0	1038859.AXAU01000007_gene5807	8.419e-254	790.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,3JTY7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
TLS2_k127_4264111_2	1038859.AXAU01000007_gene5808	1.408e-214	669.0	COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_4264111_6	1122962.AULH01000065_gene2878	1.704e-06	52.0	COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,370UI@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
TLS2_k127_4264111_5	1123355.JHYO01000034_gene550	2.92e-27	117.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TSUC@28211|Alphaproteobacteria,36XTW@31993|Methylocystaceae	28211|Alphaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_4264111_3	1380355.JNIJ01000009_gene1785	5.012e-201	646.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2TRVJ@28211|Alphaproteobacteria,3JQUM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Transport of potassium into the cell	kup	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
TLS2_k127_4264111_1	1267005.KB911259_gene3863	7.86e-223	698.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2TRKY@28211|Alphaproteobacteria,3N6FW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
TLS2_k127_4267020_0	335659.S23_22300	1.125e-308	960.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,3JUXZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	MA20_43170	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
TLS2_k127_4267020_3	1168059.KB899087_gene384	1.211e-201	635.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,3F146@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Aminotransferase class-V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TLS2_k127_4267020_8	1267005.KB911258_gene580	1.068e-137	449.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TS1P@28211|Alphaproteobacteria,3N629@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S11 family	dacC	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
TLS2_k127_4267020_14	426117.M446_6278	1.53e-66	234.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2U72D@28211|Alphaproteobacteria,1JS61@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
TLS2_k127_4267020_9	1267005.KB911258_gene582	1.74e-121	401.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2TV3E@28211|Alphaproteobacteria,3N73W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA polymerase III, delta subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
TLS2_k127_4267020_2	1267005.KB911258_gene583	3.52e-246	770.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2TQKA@28211|Alphaproteobacteria,3N62K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
TLS2_k127_4267020_10	582899.Hden_1728	2.227e-109	360.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2TS88@28211|Alphaproteobacteria,3N6BD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	TatD family	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
TLS2_k127_4267020_12	1267005.KB911258_gene585	1.178e-97	334.0	COG1235@1|root,COG1235@2|Bacteria,1MVJH@1224|Proteobacteria,2TQQN@28211|Alphaproteobacteria,3N6M2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	phnP	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
TLS2_k127_4267020_7	1267005.KB911256_gene1940	5.175e-142	458.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria,3N805@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	HJ	Prokaryotic glutathione synthetase, ATP-grasp domain	rimK	-	6.3.2.32	ko:K05844,ko:K14940	ko00680,ko01120,map00680,map01120	-	R09401	RC00064,RC00090	ko00000,ko00001,ko01000,ko03009	-	-	-	RimK,Zn_protease
TLS2_k127_4267020_4	1267005.KB911259_gene4038	9.679e-176	565.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2U0DN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	BT1
TLS2_k127_4267020_1	717785.HYPMC_0346	4.457e-299	937.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2TRHK@28211|Alphaproteobacteria,3N62R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
TLS2_k127_4267020_11	1267005.KB911256_gene1769	5.273e-105	353.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2TRZ5@28211|Alphaproteobacteria,3N6SW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
TLS2_k127_4267020_6	670307.HYPDE_23783	3.287e-142	458.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2TUHH@28211|Alphaproteobacteria,3N6PE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
TLS2_k127_4267020_5	1267005.KB911256_gene1767	6.779e-143	468.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria,3N67F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS2_k127_4267020_13	1267005.KB911256_gene1766	3.48e-91	317.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2TQZB@28211|Alphaproteobacteria,3N6P4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
TLS2_k127_4267020_15	1161401.ASJA01000001_gene397	9.922e-13	73.0	COG1589@1|root,COG1589@2|Bacteria,1MY1Q@1224|Proteobacteria,2TQPU@28211|Alphaproteobacteria,43Y92@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	POTRA domain, FtsQ-type	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
TLS2_k127_4271678_4	419610.Mext_0341	2.141e-06	53.0	COG3474@1|root,COG3474@2|Bacteria,1RIDN@1224|Proteobacteria,2U142@28211|Alphaproteobacteria,1JSHF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Cytochrome c, class I	cyc	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
TLS2_k127_4271678_1	717785.HYPMC_0631	3.39e-108	355.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2TUQM@28211|Alphaproteobacteria,3N8R9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
TLS2_k127_4271678_0	864069.MicloDRAFT_00065530	9.087e-127	413.0	COG0077@1|root,COG0077@2|Bacteria,1MU60@1224|Proteobacteria,2TSUT@28211|Alphaproteobacteria,1JRS9@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	PDT
TLS2_k127_4271678_2	582899.Hden_0327	3.36e-40	151.0	COG0791@1|root,COG0791@2|Bacteria,1MW03@1224|Proteobacteria,2TSFG@28211|Alphaproteobacteria,3N6WK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,SH3_3
TLS2_k127_427898_3	1122132.AQYH01000004_gene1486	1.501e-108	361.0	COG0667@1|root,COG0667@2|Bacteria,1MWGQ@1224|Proteobacteria,2TUJ8@28211|Alphaproteobacteria,4BDPI@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Aldo/keto reductase family	-	-	1.1.1.122	ko:K00064	ko00051,ko00053,ko01100,ko01110,ko01120,map00051,map00053,map01100,map01110,map01120	M00114	R07675,R08926	RC00066,RC00161	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldo_ket_red
TLS2_k127_427898_2	864069.MicloDRAFT_00043190	1.934e-118	392.0	COG0665@1|root,COG0665@2|Bacteria,1N1TN@1224|Proteobacteria,2TR7B@28211|Alphaproteobacteria,1JT6N@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM FAD dependent oxidoreductase	thiO	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
TLS2_k127_427898_4	1121106.JQKB01000007_gene1099	9.96e-89	299.0	COG1028@1|root,COG1028@2|Bacteria,1MUPX@1224|Proteobacteria,2URPZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_427898_5	1211115.ALIQ01000015_gene2285	8.895e-59	207.0	COG1764@1|root,COG1764@2|Bacteria,1RH9U@1224|Proteobacteria,2U768@28211|Alphaproteobacteria,3NBA9@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	OsmC-like protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
TLS2_k127_427898_7	438753.AZC_4368	3.592e-34	136.0	COG3613@1|root,COG3613@2|Bacteria,1N0AK@1224|Proteobacteria,2UCQW@28211|Alphaproteobacteria,3EZME@335928|Xanthobacteraceae	28211|Alphaproteobacteria	F	Nucleoside 2-deoxyribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
TLS2_k127_427898_8	59538.XP_005974546.1	6.554e-34	136.0	COG0494@1|root,KOG2839@2759|Eukaryota,3A10T@33154|Opisthokonta	33154|Opisthokonta	T	NUDIX domain	-	-	3.6.1.52	ko:K07766	-	-	-	-	ko00000,ko01000	-	-	-	NUDIX
TLS2_k127_427898_0	1122135.KB893171_gene2110	3.945e-190	614.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Phosphate	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
TLS2_k127_427898_9	670307.HYPDE_37393	6.032e-06	54.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2TRPB@28211|Alphaproteobacteria,3N671@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DUF3646
TLS2_k127_427898_1	648757.Rvan_1574	4.036e-170	556.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2TRPB@28211|Alphaproteobacteria,3N671@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DUF3646
TLS2_k127_427898_6	1267005.KB911256_gene1826	1.148e-35	140.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2UBQB@28211|Alphaproteobacteria,3N760@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
TLS2_k127_430531_1	1082931.KKY_1000	3.868e-64	223.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2TT38@28211|Alphaproteobacteria,3N68H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
TLS2_k127_430531_0	1125973.JNLC01000016_gene2849	1.182e-121	414.0	COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JQV4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,PAS_3,PAS_4,PAS_7,PAS_8,PAS_9
TLS2_k127_430531_3	1282876.BAOK01000002_gene466	4.889e-40	152.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2UBXX@28211|Alphaproteobacteria,4BQZW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02113,ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
TLS2_k127_430531_2	391937.NA2_11280	1.061e-61	213.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,43H5H@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS2_k127_4324534_15	398525.KB900701_gene2636	2.319e-39	148.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2TR37@28211|Alphaproteobacteria,3JVES@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Malate/L-lactate dehydrogenase	MA20_06110	-	1.1.1.350	ko:K00073,ko:K13574	ko00230,ko01120,map00230,map01120	-	R02935,R02936	RC00169	ko00000,ko00001,ko01000	-	-	-	Ldh_2
TLS2_k127_4324534_19	78245.Xaut_2027	1.24e-17	90.0	COG1873@1|root,COG1873@2|Bacteria,1N6X0@1224|Proteobacteria,2UFAR@28211|Alphaproteobacteria,3F016@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
TLS2_k127_4324534_12	1267005.KB911256_gene1789	2.735e-53	189.0	COG3861@1|root,COG3861@2|Bacteria,1MZM2@1224|Proteobacteria,2UBTQ@28211|Alphaproteobacteria,3N76T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
TLS2_k127_4324534_6	1205680.CAKO01000002_gene2549	1.399e-90	306.0	COG3618@1|root,COG3618@2|Bacteria,1R4T9@1224|Proteobacteria,2TRFM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM amidohydrolase 2	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_4324534_14	883080.HMPREF9697_00231	7.474e-46	171.0	COG2755@1|root,COG2755@2|Bacteria,1RC1Q@1224|Proteobacteria,2U6XX@28211|Alphaproteobacteria,3JYMT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS2_k127_4324534_2	626887.J057_06206	3.955e-138	451.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG4664 TRAP-type mannitol chloroaromatic compound transport system large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_4324534_17	1304874.JAFY01000005_gene1476	2.157e-28	122.0	COG4665@1|root,COG4665@2|Bacteria,3TC0P@508458|Synergistetes	508458|Synergistetes	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_4324534_16	1120956.JHZK01000015_gene2962	9.676e-39	159.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS5C@28211|Alphaproteobacteria,1JP9J@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_4324534_18	1144312.PMI09_02134	2.307e-22	100.0	COG3415@1|root,COG3415@2|Bacteria,1RJ69@1224|Proteobacteria,2UHDF@28211|Alphaproteobacteria,4BFKM@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	location bacterial cytoplasm Psort-Score 0.0959	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,HTH_Tnp_Tc3_2,PAX
TLS2_k127_4324534_7	1411123.JQNH01000001_gene3813	3.092e-90	327.0	COG0280@1|root,COG0280@2|Bacteria,1QTS5@1224|Proteobacteria,2TVFP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	phosphate acetyltransferase	-	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
TLS2_k127_4324534_0	1411123.JQNH01000001_gene3814	7.998e-183	597.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TV99@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the citrate synthase family	prpC	-	2.3.3.1,2.3.3.5	ko:K01647,ko:K01659	ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351,R00931	RC00004,RC00067,RC00406,RC02827	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS2_k127_4324534_13	1281779.H009_11396	1.976e-48	183.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,2U22X@28211|Alphaproteobacteria,4BBT7@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_4324534_4	1449351.RISW2_00055	5.728e-97	326.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_4324534_11	1449351.RISW2_00060	8.828e-76	265.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_4324534_10	401526.TcarDRAFT_0885	6.519e-79	271.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,4H223@909932|Negativicutes	909932|Negativicutes	E	ABC transporter, ATP-binding protein	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_4324534_9	1449351.RISW2_00070	5.225e-84	285.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,4KKU7@93682|Roseivivax	28211|Alphaproteobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_4324534_3	1449351.RISW2_00075	2.342e-123	402.0	COG4177@1|root,COG4177@2|Bacteria	2|Bacteria	E	L-phenylalanine transmembrane transporter activity	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
TLS2_k127_4324534_5	1449351.RISW2_00080	1.418e-92	313.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_4324534_1	1449351.RISW2_00085	6.685e-153	494.0	COG0683@1|root,COG0683@2|Bacteria,1RBGU@1224|Proteobacteria,2U6VH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_4324534_8	1411123.JQNH01000001_gene2712	5.043e-85	291.0	COG2358@1|root,COG2358@2|Bacteria,1NSZ5@1224|Proteobacteria,2U3NZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system periplasmic component	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
TLS2_k127_4357998_12	1038858.AXBA01000002_gene3875	2.945e-08	57.0	COG2371@1|root,COG2371@2|Bacteria,1MZQZ@1224|Proteobacteria,2TVBW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly	ureE	-	-	ko:K03187	-	-	-	-	ko00000	-	-	-	UreE_C,UreE_N
TLS2_k127_4357998_0	1411123.JQNH01000001_gene2133	0.0	1011.0	COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,2TSXP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
TLS2_k127_4357998_11	1411123.JQNH01000001_gene2136	6.751e-42	166.0	COG0831@1|root,COG0832@1|root,COG0831@2|Bacteria,COG0832@2|Bacteria,1RGXE@1224|Proteobacteria,2U947@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the urease gamma subunit family	ureA	-	3.5.1.5	ko:K01430,ko:K14048	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_beta,Urease_gamma
TLS2_k127_4357998_10	1082933.MEA186_06578	4.227e-44	168.0	COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2UA0Y@28211|Alphaproteobacteria,43K34@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Hydrogenase urease accessory protein	hupE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
TLS2_k127_4357998_9	266834.SMc01941	9.876e-52	186.0	COG0831@1|root,COG0831@2|Bacteria,1RGXE@1224|Proteobacteria,2U947@28211|Alphaproteobacteria,4BF8W@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the urease gamma subunit family	ureA	-	3.5.1.5	ko:K01430,ko:K14048	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_beta,Urease_gamma
TLS2_k127_4357998_7	1211115.ALIQ01000218_gene1480	3.854e-68	241.0	COG0829@1|root,COG0829@2|Bacteria,1RABD@1224|Proteobacteria,2U57R@28211|Alphaproteobacteria,3NBS1@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureD	-	-	ko:K03190	-	-	-	-	ko00000	-	-	-	UreD
TLS2_k127_4357998_5	1469245.JFBG01000062_gene2270	6.286e-114	382.0	COG2358@1|root,COG2358@2|Bacteria	2|Bacteria	G	TRAP transporter, solute receptor (TAXI family	MA20_27285	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
TLS2_k127_4357998_1	1469245.JFBG01000062_gene2271	1.066e-219	700.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_4357998_8	936455.KI421499_gene2734	9.535e-52	196.0	COG2207@1|root,COG2207@2|Bacteria,1R5SY@1224|Proteobacteria,2VF58@28211|Alphaproteobacteria,3JWIU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS2_k127_4357998_3	189753.AXAS01000098_gene7690	4.362e-174	557.0	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,2TWTC@28211|Alphaproteobacteria,3JU3U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	MA20_29490	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_4357998_4	189753.AXAS01000098_gene7689	4.734e-118	385.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,2TSH5@28211|Alphaproteobacteria,3JSX6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	MA20_29495	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_4357998_2	1304877.KI519399_gene5333	1.738e-190	624.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2TQVU@28211|Alphaproteobacteria,3JWJH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	MA20_29500	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
TLS2_k127_4357998_6	420324.KI911948_gene9289	1.006e-80	276.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSCA@28211|Alphaproteobacteria,1JZCQ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	MA20_29505	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_4519163_0	1267005.KB911255_gene2958	0.0	1096.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria,3N655@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
TLS2_k127_4519163_2	1267005.KB911255_gene2959	1.294e-76	267.0	COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,3N8TJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Thioredoxin	MA20_42440	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
TLS2_k127_4519163_3	670307.HYPDE_37953	3.756e-74	256.0	COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,3N72B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Thioredoxin	MA20_42440	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
TLS2_k127_4519163_4	1234595.C725_1387	3.212e-42	159.0	COG2940@1|root,COG2940@2|Bacteria,1N3VM@1224|Proteobacteria,2UDY0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG2940 Proteins containing SET domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
TLS2_k127_4519163_1	1267005.KB911263_gene1349	2.511e-95	325.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2TTZ4@28211|Alphaproteobacteria,3N7NY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
TLS2_k127_4520546_9	582899.Hden_1052	6.878e-40	156.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2UBSI@28211|Alphaproteobacteria,3N7BU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
TLS2_k127_4520546_4	1267005.KB911258_gene268	6.191e-98	325.0	COG1278@1|root,COG1278@2|Bacteria,1RAUE@1224|Proteobacteria,2U0S7@28211|Alphaproteobacteria,3N6P7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Cold-shock	cspB	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_4520546_6	59538.XP_005964074.1	4.052e-73	250.0	COG0346@1|root,KOG2944@2759|Eukaryota	2759|Eukaryota	E	lactoylglutathione lyase activity	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4
TLS2_k127_4520546_2	426117.M446_4371	1.277e-133	438.0	COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2TR1K@28211|Alphaproteobacteria,1JTR9@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM HI0933 family protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
TLS2_k127_4520546_8	1267005.KB911263_gene1287	6.565e-41	152.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2UBTW@28211|Alphaproteobacteria,3N74F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0009399,GO:0071941,GO:0097159,GO:1901363	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
TLS2_k127_4520546_0	717785.HYPMC_2068	3.333e-171	549.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2TUXJ@28211|Alphaproteobacteria,3N6AH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TLS2_k127_4520546_5	631454.N177_2605	5.169e-74	255.0	COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,2U78A@28211|Alphaproteobacteria,1JNUY@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	SNARE associated Golgi protein	dedA	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_4520546_7	670307.HYPDE_40833	1.406e-54	196.0	COG1495@1|root,COG1495@2|Bacteria,1N89I@1224|Proteobacteria,2UF49@28211|Alphaproteobacteria,3N77P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Disulfide bond formation protein DsbB	dsbB	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
TLS2_k127_4520546_3	582899.Hden_3418	1.264e-100	336.0	COG1011@1|root,COG1011@2|Bacteria,1PHPQ@1224|Proteobacteria,2TUDN@28211|Alphaproteobacteria,3N6T8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Pyrimidine 5'-nucleotidase	MA20_21845	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
TLS2_k127_4520546_1	582899.Hden_3419	1.263e-154	492.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2TQQS@28211|Alphaproteobacteria,3N62P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
TLS2_k127_4520546_10	1267005.KB911255_gene2395	2.464e-20	98.0	COG0542@1|root,COG0542@2|Bacteria,1NXPQ@1224|Proteobacteria,2UTUZ@28211|Alphaproteobacteria,3N8QT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Clp amino terminal domain, pathogenicity island component	-	-	-	-	-	-	-	-	-	-	-	-	Clp_N
TLS2_k127_4575227_0	1267005.KB911257_gene922	2.036e-232	729.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria,3N6HY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
TLS2_k127_4575227_3	717785.HYPMC_4061	8.455e-64	225.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,2TTN7@28211|Alphaproteobacteria,3N8ZS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS2_k127_4575227_1	1267005.KB911255_gene2421	5.221e-112	365.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,2TS9Y@28211|Alphaproteobacteria,3N68B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
TLS2_k127_4575227_2	717785.HYPMC_4063	1.833e-110	368.0	COG2177@1|root,COG2177@2|Bacteria,1MXKQ@1224|Proteobacteria,2TSNT@28211|Alphaproteobacteria,3N6YI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Cell division protein	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
TLS2_k127_4622752_2	1205680.CAKO01000037_gene1324	5.903e-148	476.0	COG0596@1|root,COG0596@2|Bacteria,1N5ZI@1224|Proteobacteria,2TY7W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_4622752_4	1267005.KB911260_gene3543	6.508e-92	312.0	COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria,2TU7N@28211|Alphaproteobacteria,3N6Z0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_4622752_1	1267005.KB911260_gene3542	6.895e-194	611.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2TR87@28211|Alphaproteobacteria,3N633@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
TLS2_k127_4622752_3	1267005.KB911260_gene3541	4.22e-145	469.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2TS0D@28211|Alphaproteobacteria,3N687@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
TLS2_k127_4622752_5	671143.DAMO_0872	1.88e-67	241.0	COG2267@1|root,COG2267@2|Bacteria,2NRR1@2323|unclassified Bacteria	2|Bacteria	I	Alpha/beta hydrolase family	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_4622752_6	582899.Hden_1854	1.98e-23	116.0	COG2319@1|root,COG2319@2|Bacteria,1RBEA@1224|Proteobacteria,2U6AK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Domain of unknown function (DUF4384)	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,DUF4384
TLS2_k127_4622752_0	1267005.KB911256_gene1901	2.431e-248	775.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,3N6JN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	UvrD-like helicase C-terminal domain	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS2_k127_4724324_7	1121861.KB899934_gene491	4.054e-63	235.0	COG0559@1|root,COG0559@2|Bacteria,1R5H9@1224|Proteobacteria,2TUJ6@28211|Alphaproteobacteria,2JVT7@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
TLS2_k127_4724324_3	1298867.AUES01000006_gene381	9.255e-104	342.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSA6@28211|Alphaproteobacteria,3JUSQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	MA20_02445	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_4724324_4	1207063.P24_16370	3.076e-101	334.0	COG0411@1|root,COG0411@2|Bacteria,1MVAU@1224|Proteobacteria,2TVRN@28211|Alphaproteobacteria,2JVDX@204441|Rhodospirillales	204441|Rhodospirillales	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_4724324_0	1207063.P24_16375	3.528e-219	691.0	COG0683@1|root,COG0683@2|Bacteria,1Q1P3@1224|Proteobacteria,2TUJG@28211|Alphaproteobacteria,2JVUV@204441|Rhodospirillales	204441|Rhodospirillales	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
TLS2_k127_4724324_5	1267005.KB911264_gene3195	2.392e-95	321.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2TZPK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF502)	MA20_12960	-	-	-	-	-	-	-	-	-	-	-	DUF502
TLS2_k127_4724324_1	1267005.KB911256_gene1956	2.676e-124	406.0	COG2267@1|root,COG2267@2|Bacteria,1MWDA@1224|Proteobacteria,2TSZ4@28211|Alphaproteobacteria,3N6NW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Alpha beta hydrolase fold	pldB	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
TLS2_k127_4724324_2	1205680.CAKO01000004_gene3638	1.997e-108	358.0	COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,2U149@28211|Alphaproteobacteria,2JQ1X@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_4724324_6	1122132.AQYH01000010_gene3800	6.128e-84	296.0	COG0642@1|root,COG2205@2|Bacteria,1RCSX@1224|Proteobacteria,2U5U3@28211|Alphaproteobacteria,4B9U2@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	divJ	-	2.7.13.3	ko:K11357	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
TLS2_k127_4724324_9	1402135.SUH3_12945	7.594e-08	61.0	COG3409@1|root,COG3409@2|Bacteria,1NGMY@1224|Proteobacteria,2UJNJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
TLS2_k127_4724324_8	582899.Hden_2640	1.7e-16	80.0	COG3750@1|root,COG3750@2|Bacteria,1N77J@1224|Proteobacteria,2UFX6@28211|Alphaproteobacteria,3N7B0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0335 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2312
TLS2_k127_4732745_4	452662.SJA_C1-10050	8.11e-83	282.0	COG1293@1|root,COG1293@2|Bacteria,1QU3W@1224|Proteobacteria,2TVYF@28211|Alphaproteobacteria,2KAH7@204457|Sphingomonadales	204457|Sphingomonadales	K	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4732745_0	1120792.JAFV01000001_gene244	1.065e-192	625.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2TRU8@28211|Alphaproteobacteria,36XPI@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
TLS2_k127_4732745_8	1429916.X566_20325	2.601e-42	159.0	COG0346@1|root,COG0346@2|Bacteria,1RH4D@1224|Proteobacteria,2U7GX@28211|Alphaproteobacteria,3JYQ4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_4732745_9	717785.HYPMC_4675	4.649e-42	171.0	COG5488@1|root,COG5488@2|Bacteria,1NPQQ@1224|Proteobacteria,2UB81@28211|Alphaproteobacteria,3N7A8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Integral membrane protein (DUF2244)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2244
TLS2_k127_4732745_2	1122963.AUHB01000002_gene897	8.782e-98	325.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,2TRI2@28211|Alphaproteobacteria,36XHS@31993|Methylocystaceae	28211|Alphaproteobacteria	L	FES	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
TLS2_k127_4732745_7	1121033.AUCF01000001_gene1986	4.778e-53	201.0	COG2813@1|root,COG2813@2|Bacteria,1MXE9@1224|Proteobacteria,2TSBA@28211|Alphaproteobacteria,2JSFY@204441|Rhodospirillales	204441|Rhodospirillales	J	16S RNA G1207 methylase RsmC	-	-	2.1.1.172	ko:K00564	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS
TLS2_k127_4732745_1	1267005.KB911257_gene731	6.614e-138	441.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2TQXD@28211|Alphaproteobacteria,3N6KD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS2_k127_4732745_13	1267005.KB911257_gene639	6.874e-15	83.0	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,2UJJF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	-	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
TLS2_k127_4732745_3	1267005.KB911257_gene638	1.151e-97	325.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2TSS5@28211|Alphaproteobacteria,3N6Q6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
TLS2_k127_4732745_12	1229172.JQFA01000004_gene702	1.855e-25	117.0	COG1670@1|root,COG1670@2|Bacteria,1GA76@1117|Cyanobacteria,1HGA7@1150|Oscillatoriales	1117|Cyanobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS2_k127_4732745_11	717785.HYPMC_0112	4.859e-39	152.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2UBUX@28211|Alphaproteobacteria,3N70Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
TLS2_k127_4732745_10	582899.Hden_0201	1.694e-39	154.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2UBT3@28211|Alphaproteobacteria,3N72P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L21p
TLS2_k127_4732745_5	1304878.AUGD01000008_gene6006	2.154e-73	250.0	COG0454@1|root,COG0456@2|Bacteria,1MZUT@1224|Proteobacteria,2UC9I@28211|Alphaproteobacteria,3JW26@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) family	MA20_05250	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_4732745_6	384765.SIAM614_27098	2.677e-54	190.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	3-hydroxyacyl-coa dehydrogenase	hbdA	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_4750346_4	388399.SSE37_21520	1.186e-96	318.0	COG1335@1|root,COG3386@1|root,COG1335@2|Bacteria,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,2TSXG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Gluconolactonase	MA20_13995	-	3.1.1.17	ko:K01053,ko:K14274	ko00030,ko00040,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00040,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02427,R02933,R03751	RC00537,RC00713,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Isochorismatase,SGL
TLS2_k127_4750346_3	1038860.AXAP01000012_gene1290	4.536e-136	439.0	COG2175@1|root,COG2175@2|Bacteria,1MVI6@1224|Proteobacteria,2TVHF@28211|Alphaproteobacteria,3JU8R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	MA20_18150	-	-	ko:K06912	ko00361,ko01120,ko01220,map00361,map01120,map01220	-	R05419,R05493	RC01371,RC01372	ko00000,ko00001,ko01000	-	-	-	TauD
TLS2_k127_4750346_1	1380355.JNIJ01000026_gene1330	8.433e-162	516.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,3JUIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_4750346_2	1380355.JNIJ01000026_gene1331	9.333e-153	494.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VF5U@28211|Alphaproteobacteria,3JXA1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_4750346_0	1205680.CAKO01000040_gene514	5.388e-168	551.0	COG0747@1|root,COG0747@2|Bacteria,1PFW6@1224|Proteobacteria,2U1GT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_4756987_4	1267005.KB911263_gene1289	3.187e-135	432.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQW2@28211|Alphaproteobacteria,3N61P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Sigma-54 interaction domain	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS2_k127_4756987_0	1267005.KB911263_gene1335	2.179e-181	572.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2TSMS@28211|Alphaproteobacteria,3N6K3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
TLS2_k127_4756987_2	1267005.KB911263_gene1336	1.227e-146	471.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria,3N654@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	prohibitin homologues	qmcA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
TLS2_k127_4756987_7	1267005.KB911263_gene1337	2.744e-39	152.0	COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,2UC8X@28211|Alphaproteobacteria,3N7B3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	OU	NfeD-like C-terminal, partner-binding	MA20_06475	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
TLS2_k127_4756987_10	1207075.PputUW4_05226	8.249e-18	88.0	COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,1S5W4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	OU	Membrane protein implicated in regulation of membrane protease activity	ybbJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
TLS2_k127_4756987_8	648757.Rvan_0449	6.994e-35	145.0	2EHAM@1|root,33B2H@2|Bacteria,1MY41@1224|Proteobacteria,2U1A7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_22125	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4756987_9	876269.ARWA01000001_gene3041	1.755e-30	132.0	COG1846@1|root,COG1846@2|Bacteria,1N7G0@1224|Proteobacteria,2UA2S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_4756987_6	1005048.CFU_1549	9.995e-47	174.0	COG2050@1|root,COG2050@2|Bacteria,1RK46@1224|Proteobacteria,2VPWT@28216|Betaproteobacteria,475W2@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_4756987_5	648757.Rvan_0086	1.004e-108	366.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2TRA4@28211|Alphaproteobacteria,3N9IT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4756987_1	316055.RPE_3843	4.381e-156	507.0	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,2TSMQ@28211|Alphaproteobacteria,3JQPE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	MatE	MA20_06615	-	-	-	-	-	-	-	-	-	-	-	MatE
TLS2_k127_4756987_3	1122918.KB907249_gene3893	2.494e-139	462.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,26WSQ@186822|Paenibacillaceae	91061|Bacilli	C	CoA-transferase family III	frc	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS2_k127_4756987_11	1123504.JQKD01000098_gene2964	3.579e-11	66.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VI39@28216|Betaproteobacteria,4AJ2P@80864|Comamonadaceae	28216|Betaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_4762044_13	1267005.KB911255_gene2909	6.756e-10	61.0	COG4963@1|root,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2TUDS@28211|Alphaproteobacteria,3N6AI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	AAA domain	cpaE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ
TLS2_k127_4762044_10	1267005.KB911255_gene2910	4.91e-59	213.0	COG5461@1|root,COG5461@2|Bacteria,1MWWE@1224|Proteobacteria,2TU2Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	TIGRFAM pilus (Caulobacter type) biogenesis lipoprotein CpaD	cpaD	-	-	ko:K02281	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Pilus_CpaD
TLS2_k127_4762044_3	1267005.KB911255_gene2911	3.823e-168	547.0	COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2TRNN@28211|Alphaproteobacteria,3N6MY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Belongs to the GSP D family	cpaC	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
TLS2_k127_4762044_9	1267005.KB911255_gene2912	3.639e-77	266.0	COG3745@1|root,COG3745@2|Bacteria,1MW75@1224|Proteobacteria,2TTPE@28211|Alphaproteobacteria,3N7W3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Flp pilus assembly protein RcpC/CpaB	cpaB	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
TLS2_k127_4762044_11	1411123.JQNH01000001_gene152	1.666e-49	181.0	COG4960@1|root,COG4960@2|Bacteria,1RAYG@1224|Proteobacteria,2TSVX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	OU	Peptidase A24A, prepilin type IV	cpaA	-	3.4.23.43	ko:K02278	-	-	-	-	ko00000,ko01000,ko02035,ko02044	-	-	-	Peptidase_A24
TLS2_k127_4762044_14	1500304.JQKY01000004_gene1575	1.307e-08	60.0	COG3847@1|root,COG3847@2|Bacteria,1NGVU@1224|Proteobacteria,2UJE8@28211|Alphaproteobacteria,4BGUV@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	Flp pilus assembly protein, pilin Flp	pilA	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
TLS2_k127_4762044_1	663610.JQKO01000013_gene1815	4.687e-196	643.0	COG5373@1|root,COG5373@2|Bacteria,1N08V@1224|Proteobacteria,2TWNB@28211|Alphaproteobacteria,3NAM3@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
TLS2_k127_4762044_6	1267005.KB911257_gene678	9.489e-105	348.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2TRFS@28211|Alphaproteobacteria,3N6SV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	COG0500 SAM-dependent methyltransferases	bioC	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
TLS2_k127_4762044_12	670307.HYPDE_35903	1.085e-45	175.0	COG1028@1|root,COG1028@2|Bacteria	670307.HYPDE_35903|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	-
TLS2_k127_4762044_4	395964.KE386496_gene398	3.19e-155	497.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2TSPP@28211|Alphaproteobacteria,3N9W5@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	Initiation factor 2 subunit family	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
TLS2_k127_4762044_7	1415630.U771_10705	5.441e-104	347.0	COG1028@1|root,COG1028@2|Bacteria,1MWJQ@1224|Proteobacteria,1RS2P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_4762044_0	1267005.KB911255_gene2869	2.017e-232	731.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,3N6CX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205,1.7.1.7	ko:K00088,ko:K00364	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R01134,R08240	RC00143,RC00457,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
TLS2_k127_4762044_5	1267005.KB911255_gene2871	1.743e-149	496.0	COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2TS6U@28211|Alphaproteobacteria,3N6J6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	sun1	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F
TLS2_k127_4762044_8	1380394.JADL01000010_gene4335	1.635e-96	325.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,2JQKY@204441|Rhodospirillales	204441|Rhodospirillales	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_4762044_2	1380394.JADL01000010_gene4336	1.519e-173	555.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JPPW@204441|Rhodospirillales	204441|Rhodospirillales	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_4764018_4	1211115.ALIQ01000112_gene1621	2.883e-156	497.0	COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,2TR8G@28211|Alphaproteobacteria,3NA22@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	GDP-mannose 4,6 dehydratase	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_4764018_5	1248917.ANFX01000035_gene1950	1.463e-140	452.0	COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,2TRF6@28211|Alphaproteobacteria,2K2WZ@204457|Sphingomonadales	204457|Sphingomonadales	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_4764018_7	107635.AZUO01000001_gene2275	7.813e-129	424.0	COG0438@1|root,COG0438@2|Bacteria,1MY5T@1224|Proteobacteria,2TSZW@28211|Alphaproteobacteria,36ZS2@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_4764018_11	1121033.AUCF01000010_gene4523	5.204e-97	330.0	COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,2TUQ5@28211|Alphaproteobacteria,2JR8F@204441|Rhodospirillales	204441|Rhodospirillales	S	DMSO reductase anchor subunit	-	-	-	ko:K21309	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	-	-	-	DmsC
TLS2_k127_4764018_6	488538.SAR116_2106	1.509e-132	426.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2TTE2@28211|Alphaproteobacteria,4BPV1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	ttrB	-	-	ko:K00124,ko:K21308	ko00630,ko00680,ko00920,ko01100,ko01120,ko01200,map00630,map00680,map00920,map01100,map01120,map01200	-	R00519,R11487	RC00168,RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_3,Fer4_4
TLS2_k127_4764018_0	488538.SAR116_2105	0.0	1439.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2U1PA@28211|Alphaproteobacteria,4BPCU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	psrA	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TLS2_k127_4764018_10	1144275.COCOR_06057	2.762e-103	342.0	COG1024@1|root,COG1024@2|Bacteria,1NDT7@1224|Proteobacteria,42PZ0@68525|delta/epsilon subdivisions,2WM9Y@28221|Deltaproteobacteria,2YUF3@29|Myxococcales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_4764018_3	1411123.JQNH01000001_gene2319	1.751e-232	723.0	COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,2TRM7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Sarcosine oxidase, beta subunit	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
TLS2_k127_4764018_14	1411123.JQNH01000001_gene2318	3.205e-43	160.0	COG4311@1|root,COG4311@2|Bacteria,1MZC3@1224|Proteobacteria,2UC8C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Sarcosine oxidase, delta subunit	soxD	-	1.5.3.1	ko:K00304	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxD
TLS2_k127_4764018_1	1411123.JQNH01000001_gene2317	0.0	1416.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the GcvT family	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
TLS2_k127_4764018_15	1038860.AXAP01000002_gene4854	8.559e-39	154.0	COG4583@1|root,COG4583@2|Bacteria,1N27A@1224|Proteobacteria,2UD7S@28211|Alphaproteobacteria,3K16T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Sarcosine oxidase, gamma subunit family	soxG	-	1.5.3.1	ko:K00305	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxG
TLS2_k127_4764018_12	1205680.CAKO01000002_gene2549	2.458e-95	319.0	COG3618@1|root,COG3618@2|Bacteria,1R4T9@1224|Proteobacteria,2TRFM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM amidohydrolase 2	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_4764018_8	1121106.JQKB01000137_gene4371	6.529e-106	352.0	COG1028@1|root,COG1028@2|Bacteria,1PEWK@1224|Proteobacteria,2TV4E@28211|Alphaproteobacteria,2JV22@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_4764018_2	296591.Bpro_5274	3.83e-249	786.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VIW3@28216|Betaproteobacteria,4ABSX@80864|Comamonadaceae	28216|Betaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	fadH	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
TLS2_k127_4764018_9	1267005.KB911259_gene3690	1.574e-103	346.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,2TTI6@28211|Alphaproteobacteria,3N7Y6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_4764018_13	375451.RD1_3397	4.058e-56	207.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TSD9@28211|Alphaproteobacteria,2P1XA@2433|Roseobacter	28211|Alphaproteobacteria	K	COG0583 Transcriptional regulator	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
TLS2_k127_4765731_0	1411123.JQNH01000001_gene2474	2.595e-201	634.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
TLS2_k127_4765731_4	1267005.KB911256_gene1806	3.726e-51	203.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2UBUC@28211|Alphaproteobacteria,3N7BE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
TLS2_k127_4765731_3	1267005.KB911255_gene2399	4.379e-62	218.0	COG2927@1|root,COG2927@2|Bacteria,1RGVC@1224|Proteobacteria,2U94V@28211|Alphaproteobacteria,3N6ZN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA polymerase III chi subunit	holC	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
TLS2_k127_4765731_1	1267005.KB911256_gene1939	3.517e-125	405.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2TQY8@28211|Alphaproteobacteria,3N6SD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
TLS2_k127_4765731_6	1211115.ALIQ01000214_gene156	2.571e-36	149.0	2BKDV@1|root,32EUJ@2|Bacteria,1N9UU@1224|Proteobacteria,2TSMK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4765731_5	1038860.AXAP01000091_gene3659	1.321e-37	155.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS2_k127_4765731_2	331869.BAL199_21459	3.563e-123	407.0	COG0412@1|root,COG0412@2|Bacteria,1NRB4@1224|Proteobacteria,2TU91@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TLS2_k127_4776463_14	1126627.BAWE01000005_gene6332	5.524e-64	227.0	COG0730@1|root,COG0730@2|Bacteria,1MUJB@1224|Proteobacteria,2TRWP@28211|Alphaproteobacteria,3JT50@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	MA20_44620	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_4776463_0	670307.HYPDE_31388	6.904e-319	979.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2TS4Y@28211|Alphaproteobacteria,3N6G8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
TLS2_k127_4776463_18	670307.HYPDE_31398	3.588e-30	126.0	COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,2UCIP@28211|Alphaproteobacteria,3N794@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
TLS2_k127_4776463_10	1122929.KB908233_gene3752	7.413e-106	352.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2TS6I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TLS2_k127_4776463_5	1267005.KB911259_gene3902	1.146e-142	474.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2TRYU@28211|Alphaproteobacteria,3N6PH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	SurA N-terminal domain	ppiD	-	5.2.1.8	ko:K01802,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
TLS2_k127_4776463_16	266835.14021934	4.699e-40	154.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2UBR8@28211|Alphaproteobacteria,43K87@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the HesB IscA family	erpA	-	-	ko:K13628,ko:K15724	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TLS2_k127_4776463_6	582899.Hden_1257	3.242e-130	430.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2TRCD@28211|Alphaproteobacteria,3N6IN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
TLS2_k127_4776463_2	717785.HYPMC_2693	3.162e-247	777.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2TS3Y@28211|Alphaproteobacteria,3N694@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
TLS2_k127_4776463_15	582899.Hden_1259	8.743e-44	178.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	ko:K18491	ko04550,map04550	-	-	-	ko00000,ko00001,ko03000	-	-	-	DUF4157
TLS2_k127_4776463_8	1267005.KB911260_gene3428	1.752e-120	396.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2TRJK@28211|Alphaproteobacteria,3N6TA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolase family 3 N terminal domain	nagZ	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Glyco_hydro_3
TLS2_k127_4776463_11	717785.HYPMC_2690	1.748e-104	349.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2TS1V@28211|Alphaproteobacteria,3N6TB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
TLS2_k127_4776463_12	717785.HYPMC_2689	2.743e-100	335.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2TU64@28211|Alphaproteobacteria,3N6MJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
TLS2_k127_4776463_4	1267005.KB911260_gene3431	8.996e-144	467.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,3N84I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
TLS2_k127_4776463_13	472175.EL18_02941	1.307e-89	302.0	COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,2TUA2@28211|Alphaproteobacteria,43GQE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	bacC	-	1.1.1.159	ko:K00076	ko00121,map00121	-	-	-	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
TLS2_k127_4776463_1	414684.RC1_0405	5.311e-306	955.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,2JPC0@204441|Rhodospirillales	204441|Rhodospirillales	C	malic enzyme	dme	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
TLS2_k127_4776463_20	1211115.ALIQ01000018_gene2148	3.709e-08	61.0	2EUD5@1|root,33MVI@2|Bacteria,1NPU9@1224|Proteobacteria,2UKU4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4776463_3	1267005.KB911259_gene3815	4.922e-148	482.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2TRXF@28211|Alphaproteobacteria,3N82T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
TLS2_k127_4776463_7	1411123.JQNH01000001_gene3822	1.184e-124	404.0	COG0607@1|root,COG4275@1|root,COG0607@2|Bacteria,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2TRC3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0607 Rhodanese-related sulfurtransferase	chrB	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist,Rhodanese
TLS2_k127_4776463_9	1429916.X566_18495	6.594e-111	375.0	COG0477@1|root,COG2814@2|Bacteria,1P3S4@1224|Proteobacteria,2TVAQ@28211|Alphaproteobacteria,3JTFE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4776463_17	1131814.JAFO01000001_gene3267	1.09e-35	138.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_4780698_11	1380391.JIAS01000013_gene3447	4.993e-121	398.0	COG1609@1|root,COG1609@2|Bacteria,1MUEP@1224|Proteobacteria,2TQM4@28211|Alphaproteobacteria,2JSMV@204441|Rhodospirillales	204441|Rhodospirillales	K	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
TLS2_k127_4780698_5	935840.JAEQ01000020_gene2320	7.817e-175	556.0	COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2U0KM@28211|Alphaproteobacteria,43M1M@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_4780698_10	935840.JAEQ01000020_gene2317	1.035e-129	422.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,2TSH5@28211|Alphaproteobacteria,43KGM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_4780698_4	1211115.ALIQ01000198_gene441	1.186e-208	669.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2TQVU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	MA20_14120	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
TLS2_k127_4780698_12	1126627.BAWE01000005_gene6043	2.868e-92	308.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSA6@28211|Alphaproteobacteria,3JWMS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	MA20_14125	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_4780698_17	347834.RHE_CH01539	2.99e-05	48.0	COG3415@1|root,COG3415@2|Bacteria,1RJ69@1224|Proteobacteria,2UHDF@28211|Alphaproteobacteria,4BFKM@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	location bacterial cytoplasm Psort-Score 0.0959	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,HTH_Tnp_Tc3_2,PAX
TLS2_k127_4780698_13	1380394.JADL01000001_gene2204	5.044e-69	240.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,2JWP6@204441|Rhodospirillales	204441|Rhodospirillales	C	[2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Fer2_2
TLS2_k127_4780698_2	1380394.JADL01000001_gene2205	0.0	1082.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2JPB3@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C2
TLS2_k127_4780698_14	314230.DSM3645_02368	2.618e-59	220.0	COG1319@1|root,COG1319@2|Bacteria,2IYV7@203682|Planctomycetes	203682|Planctomycetes	C	COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM CutM homologs	-	-	1.17.1.4,1.2.5.3	ko:K03519,ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_4780698_15	926550.CLDAP_06500	1.75e-58	207.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi	200795|Chloroflexi	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_4780698_8	1121106.JQKB01000018_gene4930	1.76e-159	533.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,2JPGD@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_4780698_7	1547437.LL06_02710	1.283e-162	526.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2TRJC@28211|Alphaproteobacteria,43HKM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cobA	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
TLS2_k127_4780698_1	1040987.AZUY01000021_gene1578	0.0	1084.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2TQYD@28211|Alphaproteobacteria,43IR1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	nasA	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TLS2_k127_4780698_16	1342301.JASD01000008_gene701	9.261e-47	171.0	COG2146@1|root,COG2146@2|Bacteria,1N03R@1224|Proteobacteria,2UC33@28211|Alphaproteobacteria,3ZXTU@60136|Sulfitobacter	28211|Alphaproteobacteria	P	Rieske-like [2Fe-2S] domain	nasE	-	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Rieske_2
TLS2_k127_4780698_0	1547437.LL06_02695	0.0	1296.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2TS8I@28211|Alphaproteobacteria,43HNG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nirB	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2
TLS2_k127_4780698_3	1547437.LL06_02690	5.551e-263	821.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TUIC@28211|Alphaproteobacteria,43J8C@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	ABC transporter	cmpD_1	-	-	ko:K02049,ko:K15578	ko00910,ko02010,map00910,map02010	M00188,M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.16.1,3.A.1.17	-	-	ABC_tran
TLS2_k127_4780698_9	744980.TRICHSKD4_3398	9.386e-156	499.0	COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,2TQT6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	nasE	-	-	ko:K02050,ko:K15577	ko00910,ko02010,map00910,map02010	M00188,M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.16.1,3.A.1.16.2,3.A.1.17	-	-	BPD_transp_1
TLS2_k127_4780698_6	644107.SL1157_1180	1.505e-171	541.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2TS0X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	nasF	-	-	ko:K15576	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2
TLS2_k127_4802107_10	1411123.JQNH01000001_gene2740	6.128e-73	256.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2TRZ0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_3,SAF
TLS2_k127_4802107_3	1205680.CAKO01000008_gene4082	3.627e-192	612.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria,2JQ5F@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4802107_5	1267005.KB911264_gene3178	1.942e-122	400.0	COG2951@1|root,COG2951@2|Bacteria,1MVY0@1224|Proteobacteria,2TTVI@28211|Alphaproteobacteria,3N8DD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	lytic murein transglycosylase	MA20_41385	-	-	-	-	-	-	-	-	-	-	-	SLT_2
TLS2_k127_4802107_21	1320556.AVBP01000001_gene4635	1.305e-28	125.0	291YR@1|root,2ZPI9@2|Bacteria,1P7W3@1224|Proteobacteria,2UWGC@28211|Alphaproteobacteria,43QRI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4802107_7	582899.Hden_0614	4.723e-98	342.0	COG1686@1|root,COG3266@1|root,COG1686@2|Bacteria,COG3266@2|Bacteria,1MUU7@1224|Proteobacteria,2TRCV@28211|Alphaproteobacteria,3N6PX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Peptidase_S11,SPOR
TLS2_k127_4802107_17	1267005.KB911256_gene2016	1.455e-43	162.0	COG5490@1|root,COG5490@2|Bacteria,1MZW0@1224|Proteobacteria,2UC4T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	phasin family	MA20_36110	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
TLS2_k127_4802107_1	1267005.KB911260_gene3446	5.854e-230	727.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,3N6E7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	lipid A ABC exporter family, fused ATPase and inner membrane subunits	msbA2	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_4802107_18	744979.R2A130_1020	1.317e-42	165.0	COG3637@1|root,COG3637@2|Bacteria,1RBBG@1224|Proteobacteria,2U5ED@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Lipid A oxidase	lpxQ	-	-	ko:K12980	-	-	-	-	ko00000,ko01005	-	-	-	OMP_b-brl
TLS2_k127_4802107_0	883078.HMPREF9695_04340	0.0	1061.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TTAY@28211|Alphaproteobacteria,3JSTW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	MA20_38000	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TLS2_k127_4802107_6	1437824.BN940_16146	1.321e-118	392.0	COG0665@1|root,COG0665@2|Bacteria,1MXD1@1224|Proteobacteria,2VKJ5@28216|Betaproteobacteria,3T3CA@506|Alcaligenaceae	28216|Betaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
TLS2_k127_4802107_14	1267005.KB911257_gene939	9.641e-59	218.0	COG2240@1|root,COG2240@2|Bacteria,1MVC9@1224|Proteobacteria,2U2CH@28211|Alphaproteobacteria,3N8GA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Phosphomethylpyrimidine kinase	pdxK	-	2.7.1.35	ko:K00868	ko00750,ko01100,map00750,map01100	-	R00174,R01909,R02493	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	Phos_pyr_kin
TLS2_k127_4802107_15	1267005.KB911259_gene3822	1.83e-52	195.0	COG1309@1|root,COG1309@2|Bacteria,1N0XU@1224|Proteobacteria,2U82V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TLS2_k127_4802107_8	670307.HYPDE_24073	1.377e-92	316.0	COG1988@1|root,COG3170@1|root,COG1988@2|Bacteria,COG3170@2|Bacteria,1MZEI@1224|Proteobacteria,2UEUZ@28211|Alphaproteobacteria,3N8E2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	YdjM
TLS2_k127_4802107_11	398525.KB900701_gene3920	9.087e-68	239.0	COG0657@1|root,COG0657@2|Bacteria,1MV3J@1224|Proteobacteria,2TUQ3@28211|Alphaproteobacteria,3JW6A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	alpha/beta hydrolase fold	-	-	3.5.1.9	ko:K01432	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_3
TLS2_k127_4802107_9	1267005.KB911259_gene3929	1.421e-84	286.0	COG0500@1|root,COG0500@2|Bacteria,1QVD3@1224|Proteobacteria,2TX0Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Methyltransf_25
TLS2_k127_4802107_13	1123229.AUBC01000001_gene1606	1.957e-61	220.0	COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,2U5GF@28211|Alphaproteobacteria,3JWEW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase	MA20_19220	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
TLS2_k127_4802107_20	1205680.CAKO01000040_gene680	5.787e-34	133.0	COG2329@1|root,COG2329@2|Bacteria,1NDM8@1224|Proteobacteria,2UG48@28211|Alphaproteobacteria,2JY9Y@204441|Rhodospirillales	204441|Rhodospirillales	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4802107_4	1267005.KB911260_gene3463	2.824e-162	522.0	28JPV@1|root,2Z9FT@2|Bacteria,1PJPU@1224|Proteobacteria,2U5WB@28211|Alphaproteobacteria,3N7ZA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4802107_19	1267005.KB911263_gene1325	4.264e-39	149.0	COG5490@1|root,COG5490@2|Bacteria,1Q86G@1224|Proteobacteria,2VECD@28211|Alphaproteobacteria,3N98J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Phasin protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
TLS2_k127_4802107_2	1502851.FG93_02724	1.335e-224	709.0	COG2309@1|root,COG2309@2|Bacteria,1MW2Y@1224|Proteobacteria,2TSGB@28211|Alphaproteobacteria,3JTH5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Thermophilic metalloprotease (M29)	ampS	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
TLS2_k127_4802107_12	1232683.ADIMK_0861	1.251e-65	229.0	COG0563@1|root,COG0563@2|Bacteria,1RCIS@1224|Proteobacteria,1S692@1236|Gammaproteobacteria,467RY@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	COG0563 Adenylate kinase and related kinases	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4827445_26	1120792.JAFV01000001_gene3318	4.881e-25	108.0	COG1878@1|root,COG1878@2|Bacteria,1MWWB@1224|Proteobacteria,2TSIG@28211|Alphaproteobacteria,36Z2V@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_4827445_4	670307.HYPDE_23593	2.49e-196	621.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria,3N6KW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_4827445_5	582899.Hden_0206	1.508e-167	534.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria,3N6EK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
TLS2_k127_4827445_23	1120983.KB894570_gene1597	1.299e-27	117.0	COG1051@1|root,COG1051@2|Bacteria,1N1KH@1224|Proteobacteria,2UDI2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Belongs to the Nudix hydrolase family	MA20_42070	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_4827445_22	1541065.JRFE01000014_gene1150	1.418e-34	142.0	COG0457@1|root,COG0457@2|Bacteria,1GR0N@1117|Cyanobacteria	1117|Cyanobacteria	S	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
TLS2_k127_4827445_11	717785.HYPMC_1449	3.883e-110	367.0	COG1703@1|root,COG1703@2|Bacteria,1R44P@1224|Proteobacteria,2TW2E@28211|Alphaproteobacteria,3N8SH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS2_k127_4827445_13	1411123.JQNH01000001_gene2691	8.149e-99	334.0	COG1984@1|root,COG1984@2|Bacteria,1MU9H@1224|Proteobacteria,2TS7P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	allophanate hydrolase subunit 2	ybgK	-	3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005	RC02756	ko00000,ko00001,ko01000	-	-	-	CT_A_B
TLS2_k127_4827445_17	795666.MW7_3336	2.901e-76	263.0	COG2049@1|root,COG2049@2|Bacteria,1MWRB@1224|Proteobacteria,2VQQM@28216|Betaproteobacteria,1K2IY@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Allophanate hydrolase, subunit 1	kipI	-	-	-	-	-	-	-	-	-	-	-	CT_C_D
TLS2_k127_4827445_12	1187851.A33M_3624	1.821e-103	356.0	COG1540@1|root,COG1540@2|Bacteria,1MUYV@1224|Proteobacteria,2TQUC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the UPF0271 (lamB) family	ybgL	-	-	ko:K07160	-	-	-	-	ko00000	-	-	-	LamB_YcsF
TLS2_k127_4827445_27	1415756.JQMY01000001_gene2966	8.827e-23	102.0	COG3788@1|root,COG3788@2|Bacteria,1RDHP@1224|Proteobacteria,2UDRD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	relative of glutathione S-transferase, MAPEG superfamily	-	-	-	ko:K07136	-	-	-	-	ko00000	-	-	-	MAPEG
TLS2_k127_4827445_1	1120983.KB894572_gene3146	1.086e-251	799.0	29ISC@1|root,2Z7VE@2|Bacteria,1MWUK@1224|Proteobacteria,2TTFU@28211|Alphaproteobacteria,1JPZS@119043|Rhodobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
TLS2_k127_4827445_15	62928.azo3945	7.754e-96	342.0	COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,2W1GY@28216|Betaproteobacteria,2KZNW@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
TLS2_k127_4827445_18	744979.R2A130_2763	4.643e-54	193.0	COG0745@1|root,COG0745@2|Bacteria,1RD6H@1224|Proteobacteria	1224|Proteobacteria	T	response regulator	-	-	-	ko:K02485	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg
TLS2_k127_4827445_6	258594.RPA1691	1.278e-139	462.0	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,2TSMQ@28211|Alphaproteobacteria,3JQPE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	MatE	MA20_06615	-	-	-	-	-	-	-	-	-	-	-	MatE
TLS2_k127_4827445_19	670307.HYPDE_36048	1.576e-48	174.0	2AMHV@1|root,31CDG@2|Bacteria,1RGVA@1224|Proteobacteria,2U98Q@28211|Alphaproteobacteria,3N74X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1153)	MA20_11245	-	-	-	-	-	-	-	-	-	-	-	DUF1153
TLS2_k127_4827445_14	1267005.KB911260_gene3435	4.188e-98	329.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2TTIX@28211|Alphaproteobacteria,3N6HE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
TLS2_k127_4827445_29	1125973.JNLC01000016_gene2807	1.406e-16	87.0	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2UF4Z@28211|Alphaproteobacteria,3JVG6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	GO:0003674,GO:0005215	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS2_k127_4827445_30	1500257.JQNM01000009_gene1028	1.567e-16	81.0	COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,2UFBN@28211|Alphaproteobacteria,4BH2E@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	GO:0003674,GO:0005215	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS2_k127_4827445_8	582899.Hden_2486	1.179e-137	440.0	COG0745@1|root,COG0745@2|Bacteria,1MWVI@1224|Proteobacteria,2TRSP@28211|Alphaproteobacteria,3N69F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	two component transcriptional regulator	ctrA	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K02483,ko:K13584	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_4827445_24	1267005.KB911259_gene3754	4.584e-26	111.0	2BAE2@1|root,323UI@2|Bacteria,1N2A8@1224|Proteobacteria,2UJ2Q@28211|Alphaproteobacteria,3N7BV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	flagellar export protein FliJ	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4827445_7	717785.HYPMC_0808	3.862e-139	449.0	COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,2TS53@28211|Alphaproteobacteria,3N7J7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
TLS2_k127_4827445_9	1267005.KB911256_gene1877	5.384e-130	438.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria,3N7PS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	yjcG	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
TLS2_k127_4827445_21	717785.HYPMC_0806	2.52e-36	142.0	COG4327@1|root,COG4327@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4212)	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	DUF4212
TLS2_k127_4827445_16	1211115.ALIQ01000173_gene3583	2.994e-82	280.0	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2U06A@28211|Alphaproteobacteria,3NBN2@45404|Beijerinckiaceae	28211|Alphaproteobacteria	KT	helix_turn_helix, Lux Regulon	MA20_19670	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_4827445_0	639283.Snov_0081	0.0	1187.0	COG0591@1|root,COG0642@1|root,COG0784@1|root,COG0591@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,3EYE9@335928|Xanthobacteraceae	28211|Alphaproteobacteria	T	histidine kinase A domain protein	MA20_19630	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
TLS2_k127_4827445_20	1121439.dsat_2147	1.919e-42	160.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,42RNC@68525|delta/epsilon subdivisions,2WP7G@28221|Deltaproteobacteria,2MCBB@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
TLS2_k127_4827445_28	1207063.P24_05239	2.642e-20	102.0	COG0727@1|root,COG0727@2|Bacteria,1RCAS@1224|Proteobacteria,2U68A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
TLS2_k127_4827445_10	631454.N177_2320	2.204e-119	392.0	COG0535@1|root,COG0639@1|root,COG0535@2|Bacteria,COG0639@2|Bacteria,1MU07@1224|Proteobacteria,2TSJP@28211|Alphaproteobacteria,1JPRT@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
TLS2_k127_4827445_2	1429916.X566_10345	1.484e-208	653.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TR6X@28211|Alphaproteobacteria,3JU3Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Cytochrome P450	MA20_16575	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_4827445_25	1429916.X566_10350	1.303e-25	107.0	COG1141@1|root,COG1141@2|Bacteria,1MZJU@1224|Proteobacteria,2UCKK@28211|Alphaproteobacteria,3K07G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	4Fe-4S single cluster domain of Ferredoxin I	MA20_16570	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_15
TLS2_k127_4827445_3	187303.BN69_2962	5.554e-206	651.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,36XC5@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Valyl tRNA synthetase tRNA binding arm	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TLS2_k127_4869116_4	1267005.KB911255_gene2763	6.197e-20	89.0	COG1376@1|root,COG1376@2|Bacteria,1NHM3@1224|Proteobacteria,2UHVV@28211|Alphaproteobacteria,3N8IS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS2_k127_4869116_2	1353531.AZNX01000017_gene4150	2.177e-85	296.0	COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2TUT7@28211|Alphaproteobacteria,4B9II@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	2-nitropropane dioxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
TLS2_k127_4869116_3	1305735.JAFT01000005_gene533	3.139e-60	224.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2TRNX@28211|Alphaproteobacteria,2PDIF@252301|Oceanicola	28211|Alphaproteobacteria	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_4869116_0	479434.Sthe_2892	1.163e-151	503.0	COG0145@1|root,COG0145@2|Bacteria,2G7YY@200795|Chloroflexi,27ZD4@189775|Thermomicrobia	2|Bacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	oplaH	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
TLS2_k127_4869116_1	263358.VAB18032_17830	1.223e-144	481.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4DITC@85008|Micromonosporales	201174|Actinobacteria	EQ	Hydantoinase B/oxoprolinase	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
TLS2_k127_4869392_3	582899.Hden_2636	1.592e-110	361.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3N6KQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Sigma-54 interaction domain	tacA	GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat
TLS2_k127_4869392_9	266779.Meso_0684	1.377e-31	128.0	COG5470@1|root,COG5470@2|Bacteria,1N7JA@1224|Proteobacteria,2UBQW@28211|Alphaproteobacteria,43RMS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1330)	MA20_24570	-	-	-	-	-	-	-	-	-	-	-	DUF1330
TLS2_k127_4869392_6	670307.HYPDE_23903	9.038e-93	314.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2TUF7@28211|Alphaproteobacteria,3N93D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_tran_2,CDP-OH_P_transf
TLS2_k127_4869392_2	172088.AUGA01000004_gene3889	3.002e-174	560.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,2U07Z@28211|Alphaproteobacteria,3JR8H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4869392_7	1380394.JADL01000001_gene1957	8.975e-66	237.0	COG0111@1|root,COG0111@2|Bacteria,1R5FD@1224|Proteobacteria,2U0C0@28211|Alphaproteobacteria,2JSER@204441|Rhodospirillales	204441|Rhodospirillales	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh_C
TLS2_k127_4869392_5	1297865.APJD01000020_gene25	5.477e-94	319.0	COG1396@1|root,COG1396@2|Bacteria,1MWUC@1224|Proteobacteria,2TU04@28211|Alphaproteobacteria,3K692@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
TLS2_k127_4869392_0	582899.Hden_0277	9.873e-229	716.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2TT0R@28211|Alphaproteobacteria,3N65T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	GM	Belongs to the mannose-6-phosphate isomerase type 2 family	cpsB	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
TLS2_k127_4869392_1	670307.HYPDE_35948	1.369e-199	628.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TRPK@28211|Alphaproteobacteria,3N62Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Aminotransferase	aatA	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_4869392_10	1267005.KB911265_gene3583	1.365e-30	124.0	COG4530@1|root,COG4530@2|Bacteria,1N85Z@1224|Proteobacteria,2UF7V@28211|Alphaproteobacteria,3N7E5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (FYDLN_acid)	MA20_24185	-	-	-	-	-	-	-	-	-	-	-	FYDLN_acid
TLS2_k127_4869392_4	1282876.BAOK01000001_gene1696	1.42e-109	365.0	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,2TRVI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	succinylglutamate desuccinylase	doeB	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
TLS2_k127_4869392_8	75379.Tint_2248	1.682e-35	145.0	COG3409@1|root,COG3409@2|Bacteria,1N4WW@1224|Proteobacteria,2VH9D@28216|Betaproteobacteria,1KJ52@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	PFAM Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	CsgG,PG_binding_1
TLS2_k127_4869392_11	717785.HYPMC_3890	1.26e-23	102.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2U9GC@28211|Alphaproteobacteria,3N72S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
TLS2_k127_4889999_3	1267005.KB911263_gene1284	6.724e-105	346.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,3N6PB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	MazG nucleotide pyrophosphohydrolase domain	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
TLS2_k127_4889999_11	582899.Hden_0882	2.277e-16	89.0	COG3103@1|root,COG4991@2|Bacteria,1N7V3@1224|Proteobacteria,2UGQ7@28211|Alphaproteobacteria,3N98M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4889999_8	648757.Rvan_1366	1.708e-50	188.0	COG1183@1|root,COG1183@2|Bacteria,1NGCJ@1224|Proteobacteria,2TS1K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP	pcs	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050520,GO:0071704,GO:0090407,GO:1901576	2.7.8.24	ko:K01004	ko00564,ko01110,map00564,map01110	-	R05794	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_4889999_10	1267005.KB911261_gene2205	2.451e-18	89.0	2991I@1|root,2ZW53@2|Bacteria,1P4XN@1224|Proteobacteria,2UZ03@28211|Alphaproteobacteria,3N94R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4889999_5	1267005.KB911256_gene2013	6.781e-76	261.0	COG2214@1|root,COG2214@2|Bacteria,1PUS9@1224|Proteobacteria,2TT35@28211|Alphaproteobacteria,3N8YH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	DnaJ molecular chaperone homology domain	MA20_36100	-	-	-	-	-	-	-	-	-	-	-	DnaJ
TLS2_k127_4889999_4	1267005.KB911256_gene2012	7.308e-91	308.0	COG2304@1|root,COG2304@2|Bacteria,1RA4S@1224|Proteobacteria,2U5T8@28211|Alphaproteobacteria,3N6R3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4889999_6	1205680.CAKO01000002_gene2262	4.647e-72	260.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2TR9R@28211|Alphaproteobacteria,2JQM2@204441|Rhodospirillales	204441|Rhodospirillales	P	Sulfurtransferase	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS2_k127_4889999_1	172088.AUGA01000012_gene7131	3.102e-116	384.0	COG0789@1|root,COG0789@2|Bacteria,1PEAD@1224|Proteobacteria,2U2BW@28211|Alphaproteobacteria,3JXHI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_4889999_2	1205680.CAKO01000008_gene4084	2.648e-110	368.0	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2TS39@28211|Alphaproteobacteria,2JQVF@204441|Rhodospirillales	204441|Rhodospirillales	V	HlyD membrane-fusion protein of T1SS	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
TLS2_k127_4889999_9	1205680.CAKO01000008_gene4083	1.348e-33	150.0	COG1846@1|root,COG1846@2|Bacteria,1N7PQ@1224|Proteobacteria,2UF5S@28211|Alphaproteobacteria,2JU02@204441|Rhodospirillales	204441|Rhodospirillales	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
TLS2_k127_4889999_0	1205680.CAKO01000008_gene4082	1.09e-189	613.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria,2JQ5F@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4889999_7	926554.KI912627_gene1177	9.888e-51	183.0	COG0183@1|root,COG0183@2|Bacteria,1WIAR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_4896086_0	1267005.KB911256_gene1526	5.963e-246	766.0	COG1206@1|root,COG1206@2|Bacteria,1MWNQ@1224|Proteobacteria,2TR6M@28211|Alphaproteobacteria,3N6EM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
TLS2_k127_4896086_3	582899.Hden_1278	1.053e-90	304.0	2CDCV@1|root,308Y1@2|Bacteria,1N74F@1224|Proteobacteria,2TUJ4@28211|Alphaproteobacteria,3N7QI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4896086_5	189753.AXAS01000011_gene7551	2.542e-40	162.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2URQN@28211|Alphaproteobacteria,3K6JB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind
TLS2_k127_4896086_2	420324.KI912084_gene7392	4.972e-136	450.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Trans_reg_C
TLS2_k127_4896086_1	582899.Hden_0686	1.518e-141	458.0	COG0095@1|root,COG0095@2|Bacteria,1N1T8@1224|Proteobacteria,2U1PC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TLS2_k127_4896086_4	1267005.KB911255_gene2580	1.15e-62	221.0	COG3738@1|root,COG3738@2|Bacteria,1RE1M@1224|Proteobacteria,2U9JW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09974	-	-	-	-	ko00000	-	-	-	DUF1287
TLS2_k127_4900046_3	331869.BAL199_01259	5.42e-65	245.0	COG0477@1|root,COG2814@2|Bacteria,1MW6T@1224|Proteobacteria,2U1KC@28211|Alphaproteobacteria,4BR4Q@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Uncharacterised MFS-type transporter YbfB	MA20_07835	-	-	-	-	-	-	-	-	-	-	-	MFS_4
TLS2_k127_4900046_4	717785.HYPMC_2508	2.098e-30	131.0	COG5400@1|root,COG5400@2|Bacteria,1P5Z9@1224|Proteobacteria,2UXRE@28211|Alphaproteobacteria,3N98Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	conserved protein UCP033924	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4900046_1	582899.Hden_3489	8.612e-169	546.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2TQRC@28211|Alphaproteobacteria,3N67N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
TLS2_k127_4900046_0	1380394.JADL01000007_gene4482	1.231e-174	562.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2JRDX@204441|Rhodospirillales	204441|Rhodospirillales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_4900046_2	717785.HYPMC_2539	4.776e-65	229.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,2U703@28211|Alphaproteobacteria,3N6XE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	haloacid dehalogenase-like hydrolase	ppaX	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_4900046_5	935261.JAGL01000048_gene1485	1.189e-26	113.0	COG5387@1|root,COG5387@2|Bacteria,1Q3B5@1224|Proteobacteria,2TVK1@28211|Alphaproteobacteria,43GUP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	required for the assembly of the mitochondrial F1-ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ATP12
TLS2_k127_4900960_8	420662.Mpe_A0974	7.366e-16	79.0	COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2VN7W@28216|Betaproteobacteria,1KIZJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_4900960_0	1267005.KB911257_gene749	0.0	1268.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,3N6HN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS2_k127_4900960_4	1267005.KB911257_gene750	1.398e-150	491.0	COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,2TQRD@28211|Alphaproteobacteria,3N6B7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_21,AAA_23,SMC_N
TLS2_k127_4900960_3	1267005.KB911257_gene751	8.971e-168	533.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2TSRZ@28211|Alphaproteobacteria,3N66H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
TLS2_k127_4900960_1	1267005.KB911255_gene2707	6.402e-239	764.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,1PJRR@1224|Proteobacteria,2U625@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	DUF4189,PG_binding_1,Pkinase,WD40
TLS2_k127_4900960_2	1207063.P24_07256	1.215e-198	629.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,2JPKJ@204441|Rhodospirillales	204441|Rhodospirillales	C	COG0277 FAD FMN-containing dehydrogenases	-	-	1.1.2.4	ko:K00102	ko00620,map00620	-	R00197	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_4900960_5	1411123.JQNH01000001_gene2601	8.331e-116	381.0	COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,2UVAZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the 3-hydroxyisobutyrate dehydrogenase family	mmsB	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_4900960_7	1297863.APJF01000020_gene2922	3.261e-16	79.0	COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,2UVAZ@28211|Alphaproteobacteria,3JRFH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the 3-hydroxyisobutyrate dehydrogenase family	mmsB	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_4902203_4	1121403.AUCV01000001_gene998	6.606e-132	439.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,42KZU@68525|delta/epsilon subdivisions,2WJ6T@28221|Deltaproteobacteria,2MIX6@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	Sugar (and other) transporter	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
TLS2_k127_4902203_6	1089552.KI911559_gene1613	2.248e-86	300.0	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2TS39@28211|Alphaproteobacteria,2JQVF@204441|Rhodospirillales	204441|Rhodospirillales	V	HlyD membrane-fusion protein of T1SS	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
TLS2_k127_4902203_11	1121861.KB899911_gene1370	7.319e-40	153.0	COG1846@1|root,COG1846@2|Bacteria,1MZY5@1224|Proteobacteria,2U9EE@28211|Alphaproteobacteria,2JTET@204441|Rhodospirillales	204441|Rhodospirillales	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_4902203_7	1380391.JIAS01000019_gene1197	4.102e-84	286.0	COG2378@1|root,COG2378@2|Bacteria,1MXS8@1224|Proteobacteria,2TT5H@28211|Alphaproteobacteria,2JSKE@204441|Rhodospirillales	204441|Rhodospirillales	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
TLS2_k127_4902203_14	1281779.H009_11261	0.0005712	47.0	COG5457@1|root,COG5457@2|Bacteria,1P7AJ@1224|Proteobacteria,2UYEU@28211|Alphaproteobacteria,4BGRN@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1127)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1127
TLS2_k127_4902203_10	1205680.CAKO01000004_gene3652	1.485e-50	186.0	COG0346@1|root,COG0346@2|Bacteria,1RH4D@1224|Proteobacteria,2U7GX@28211|Alphaproteobacteria,2JYJT@204441|Rhodospirillales	204441|Rhodospirillales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_4902203_9	1041159.AZUW01000015_gene234	2.176e-57	205.0	COG0350@1|root,COG0350@2|Bacteria,1MVF7@1224|Proteobacteria,2TV5U@28211|Alphaproteobacteria,4B9VJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Cysteine methyltransferase	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
TLS2_k127_4902203_5	1005048.CFU_3138	2.629e-104	343.0	COG0262@1|root,COG0262@2|Bacteria,1MU1W@1224|Proteobacteria,2VHF9@28216|Betaproteobacteria,475D5@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_4902203_2	670307.HYPDE_32213	1.534e-207	652.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TTRR@28211|Alphaproteobacteria,3N85P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome P450	-	-	-	ko:K15468	-	-	-	-	ko00000,ko01008	-	-	-	p450
TLS2_k127_4902203_13	1354722.JQLS01000001_gene4807	8.328e-05	46.0	COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,2TVRD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
TLS2_k127_4902203_12	335659.S23_09770	6.445e-38	155.0	COG0625@1|root,COG0625@2|Bacteria,1NUET@1224|Proteobacteria,2TRGC@28211|Alphaproteobacteria,3JRC3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	MA20_18540	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
TLS2_k127_4902203_3	1110502.TMO_0531	7.324e-138	449.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TTRR@28211|Alphaproteobacteria,2JS9F@204441|Rhodospirillales	204441|Rhodospirillales	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_4902203_0	1297569.MESS2_50083	3.648e-265	840.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TWBA@28211|Alphaproteobacteria,43MU4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381,ko:K21416	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,E1_dh,Transket_pyr,Transketolase_C
TLS2_k127_4902203_1	288000.BBta_4127	2.576e-209	652.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,2TRCB@28211|Alphaproteobacteria,3JR3N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate. Allows growth on ACC as a nitrogen source	acdS	-	3.5.99.7,4.4.1.15	ko:K01505,ko:K05396	ko00270,map00270	-	R00997,R01874	RC00382,RC00419	ko00000,ko00001,ko01000	-	-	-	PALP
TLS2_k127_4902203_8	288000.BBta_4128	7.553e-77	259.0	COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2VG6K@28211|Alphaproteobacteria,3K6I9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS2_k127_4922706_3	1120792.JAFV01000001_gene2329	4.484e-153	491.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2TT63@28211|Alphaproteobacteria,36XP3@31993|Methylocystaceae	28211|Alphaproteobacteria	H	HemN C-terminal domain	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
TLS2_k127_4922706_7	670307.HYPDE_40813	2.808e-88	300.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,2TV4B@28211|Alphaproteobacteria,3N6S6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
TLS2_k127_4922706_11	717785.HYPMC_4705	2.503e-58	205.0	COG0346@1|root,COG0346@2|Bacteria,1RIN8@1224|Proteobacteria,2U9WM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_4922706_0	670307.HYPDE_40058	3.108e-241	749.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2TTGS@28211|Alphaproteobacteria,3N68V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
TLS2_k127_4922706_12	935548.KI912159_gene3712	3.023e-26	116.0	2E5T0@1|root,330HC@2|Bacteria,1ND4Z@1224|Proteobacteria,2VGUI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4922706_10	114615.BRADO3556	6.862e-63	222.0	COG0586@1|root,COG0586@2|Bacteria,1R0F3@1224|Proteobacteria,2U088@28211|Alphaproteobacteria,3JR8I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	SNARE associated Golgi protein	MA20_30625	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_4922706_15	670307.HYPDE_33868	8.032e-07	55.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,3N68D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_4922706_4	648757.Rvan_1580	6.556e-140	452.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,3N6IJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	qor	GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003960,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016651,GO:0016655,GO:0017091,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:1901363	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_4922706_6	1267005.KB911256_gene1831	1.525e-94	316.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2TSEJ@28211|Alphaproteobacteria,3N6N8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	-	1.6.5.3,1.6.99.3	ko:K00334,ko:K03943	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	2Fe-2S_thioredx
TLS2_k127_4922706_9	1267005.KB911260_gene3484	5.298e-78	276.0	COG5400@1|root,COG5400@2|Bacteria,1RASG@1224|Proteobacteria,2U590@28211|Alphaproteobacteria,3N7RQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1134)	MA20_46305	-	-	-	-	-	-	-	-	-	-	-	DUF1134
TLS2_k127_4922706_1	1267005.KB911255_gene2543	8.044e-186	590.0	COG4487@1|root,COG4487@2|Bacteria,1MWNT@1224|Proteobacteria,2TT7A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2130)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2130
TLS2_k127_4922706_2	883078.HMPREF9695_00187	7.783e-172	555.0	COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,2TR7I@28211|Alphaproteobacteria,3JRS7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EK	Alanine-glyoxylate amino-transferase	MA20_07365	-	-	ko:K00375,ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000,ko03000	-	-	-	Aminotran_1_2,GntR
TLS2_k127_4922706_5	398580.Dshi_1092	3.706e-101	342.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2TTP8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	bcpA	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
TLS2_k127_4922706_8	1121106.JQKB01000027_gene1865	3.868e-78	269.0	COG0695@1|root,COG0695@2|Bacteria,1RC6T@1224|Proteobacteria	1224|Proteobacteria	O	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,Glutaredoxin
TLS2_k127_4960725_8	1287116.X734_16235	0.0001373	48.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2U401@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
TLS2_k127_4960725_1	717785.HYPMC_4126	2.172e-229	722.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2TSV7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_4960725_5	670307.HYPDE_37803	7.789e-75	259.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,2TRY6@28211|Alphaproteobacteria,3N6S2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N,YjbR
TLS2_k127_4960725_3	670307.HYPDE_37783	1.507e-163	526.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2TR6G@28211|Alphaproteobacteria,3N69S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_4960725_4	717785.HYPMC_4117	7.46e-83	292.0	COG3249@1|root,COG3249@2|Bacteria,1RE2R@1224|Proteobacteria,2U7HJ@28211|Alphaproteobacteria,3N8NS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2066)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2066
TLS2_k127_4960725_6	1041142.ATTP01000004_gene4506	8.217e-48	177.0	COG5654@1|root,COG5654@2|Bacteria,1N6P3@1224|Proteobacteria,2U76F@28211|Alphaproteobacteria,4BEAK@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	RES	-	-	-	-	-	-	-	-	-	-	-	-	RES
TLS2_k127_4960725_7	314256.OG2516_18385	1.823e-17	88.0	COG5642@1|root,COG5642@2|Bacteria	2|Bacteria	T	Protein of unknown function (DUF2384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
TLS2_k127_4960725_2	1267005.KB911255_gene2997	3.973e-168	547.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,2TSQM@28211|Alphaproteobacteria,3N66B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
TLS2_k127_4960725_0	911045.PSE_0214	8.748e-271	844.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS2_k127_4980825_0	717785.HYPMC_4445	0.0	1716.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,3N6I3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Putative amidoligase enzyme (DUF2126)	MA20_16195	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
TLS2_k127_4980825_1	717785.HYPMC_4444	0.0	1124.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2TRJE@28211|Alphaproteobacteria,3N68A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Circularly permuted ATP-grasp type 2	MA20_16190	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
TLS2_k127_4980825_6	717785.HYPMC_4443	2.892e-121	396.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2TRFC@28211|Alphaproteobacteria,3N6WJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
TLS2_k127_4980825_5	1121106.JQKB01000047_gene4008	7.985e-157	502.0	COG4948@1|root,COG4948@2|Bacteria,1MXK7@1224|Proteobacteria,2TVB4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	mandelate racemase muconate lactonizing	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_4980825_12	1317124.DW2_03609	3.759e-51	190.0	COG2143@1|root,COG2143@2|Bacteria,1R72D@1224|Proteobacteria,2U68X@28211|Alphaproteobacteria,2XMKZ@285107|Thioclava	28211|Alphaproteobacteria	O	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
TLS2_k127_4980825_11	331869.BAL199_17108	3.058e-66	237.0	COG3631@1|root,COG3631@2|Bacteria,1RE9H@1224|Proteobacteria,2UACM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	ko:K07255	ko00430,map00430	-	R01685	RC00062	ko00000,ko00001,ko01000	-	-	-	SnoaL_2
TLS2_k127_4980825_7	582899.Hden_0850	2.551e-101	341.0	COG4076@1|root,COG4076@2|Bacteria,1RB85@1224|Proteobacteria,2UH6R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PRMT5 oligomerisation domain	-	-	2.1.1.319	ko:K11434	ko04068,ko04922,map04068,map04922	-	R11216,R11217,R11219	RC00003,RC02120,RC03388,RC03390	ko00000,ko00001,ko01000,ko03036	-	-	-	PRMT5_C,PrmA
TLS2_k127_4980825_13	1294273.roselon_03418	4.937e-51	188.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U70T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	methionine sulfoxide reductase	msrB1	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
TLS2_k127_4980825_10	314278.NB231_02638	1.53e-71	250.0	COG0225@1|root,COG0225@2|Bacteria,1R33Z@1224|Proteobacteria,1T62V@1236|Gammaproteobacteria,1X277@135613|Chromatiales	135613|Chromatiales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS2_k127_4980825_14	1218352.B597_005645	2.812e-43	169.0	COG2188@1|root,COG2188@2|Bacteria,1MVFM@1224|Proteobacteria,1RNPE@1236|Gammaproteobacteria,1Z3MI@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS2_k127_4980825_3	1267005.KB911257_gene1029	8.981e-207	654.0	COG0507@1|root,COG0507@2|Bacteria,1QCFP@1224|Proteobacteria,2V700@28211|Alphaproteobacteria,3N8NH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Helicase	-	-	-	-	-	-	-	-	-	-	-	-	Herpes_Helicase,PIF1
TLS2_k127_4980825_9	717785.HYPMC_0813	4.706e-98	325.0	COG1407@1|root,COG1407@2|Bacteria,1RC5G@1224|Proteobacteria,2TU2T@28211|Alphaproteobacteria,3N6YR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ICC-like phosphoesterases	MA20_22045	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
TLS2_k127_4980825_2	670307.HYPDE_24623	0.0	1116.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,3N6HF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DEAD/H associated	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
TLS2_k127_4980825_4	1054213.HMPREF9946_00394	4.266e-157	505.0	COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2UNXP@28211|Alphaproteobacteria,2JQXX@204441|Rhodospirillales	204441|Rhodospirillales	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_4980825_8	944435.AXAJ01000001_gene119	2.238e-98	342.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2VJFW@28216|Betaproteobacteria,1K5IV@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
TLS2_k127_4980825_15	1245469.S58_63350	1.704e-25	106.0	COG2755@1|root,COG2755@2|Bacteria,1MWT8@1224|Proteobacteria,2TTXF@28211|Alphaproteobacteria,3JRB1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_4985524_4	1038859.AXAU01000010_gene1745	1.096e-122	394.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TTM5@28211|Alphaproteobacteria,3JR50@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate	frc	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS2_k127_4985524_0	1380355.JNIJ01000009_gene1657	0.0	1046.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2TT9X@28211|Alphaproteobacteria,3JRKI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	oxc	-	2.2.1.6,4.1.1.8	ko:K01577,ko:K01652	ko00290,ko00630,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00630,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01908,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00620,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_4985524_5	1101190.ARWB01000001_gene1252	1.324e-88	299.0	COG1802@1|root,COG1802@2|Bacteria,1MXNF@1224|Proteobacteria,2U1PK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Regulatory protein GntR HTH	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_4985524_1	543913.D521_0540	1.065e-245	766.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
TLS2_k127_4985524_3	296591.Bpro_2795	1.444e-155	497.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VKSV@28216|Betaproteobacteria,4AC49@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
TLS2_k127_4985524_7	1120792.JAFV01000001_gene184	1.744e-44	167.0	2BKYI@1|root,32FF5@2|Bacteria,1MY1A@1224|Proteobacteria,2U1KI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
TLS2_k127_4985524_2	1177928.TH2_01700	1.498e-197	631.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,2JQBQ@204441|Rhodospirillales	204441|Rhodospirillales	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_4985524_6	991905.SL003B_2238	2.01e-49	179.0	COG3785@1|root,COG3785@2|Bacteria,1RHM7@1224|Proteobacteria,2U9MS@28211|Alphaproteobacteria,4BQID@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Hemimethylated DNA-binding protein YccV like	hspQ	-	-	ko:K11940	-	-	-	-	ko00000,ko03036	-	-	-	YccV-like
TLS2_k127_4985524_8	582899.Hden_3322	4.433e-14	77.0	2EV0A@1|root,33NFF@2|Bacteria,1NPV4@1224|Proteobacteria,2UM65@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4994147_6	331869.BAL199_01589	3.806e-113	371.0	COG1173@1|root,COG1173@2|Bacteria,1MVER@1224|Proteobacteria,2TRB3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_4994147_2	331869.BAL199_01584	3.041e-162	516.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRH6@28211|Alphaproteobacteria,4BQ46@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_4994147_0	331869.BAL199_01579	4.18e-308	948.0	COG0747@1|root,COG0747@2|Bacteria,1MWBH@1224|Proteobacteria,2TXJS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_4994147_1	1380394.JADL01000004_gene5938	1.416e-258	809.0	COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2TS1C@28211|Alphaproteobacteria,2JQY5@204441|Rhodospirillales	204441|Rhodospirillales	S	Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
TLS2_k127_4994147_3	196490.AUEZ01000005_gene3560	4.631e-162	518.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,3JVB6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	oppF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS2_k127_4994147_4	1380355.JNIJ01000026_gene1333	2.517e-151	484.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,3JRF7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS2_k127_4994147_5	1205680.CAKO01000040_gene514	3.136e-133	426.0	COG0747@1|root,COG0747@2|Bacteria,1PFW6@1224|Proteobacteria,2U1GT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_5041515_0	1510531.JQJJ01000012_gene1695	9.498e-169	536.0	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,2TR91@28211|Alphaproteobacteria,3JRA1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C,Pyr_redox_2
TLS2_k127_5041515_1	1380394.JADL01000010_gene4160	8.529e-124	406.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,2JZPA@204441|Rhodospirillales	204441|Rhodospirillales	E	Cobalamin-independent synthase, Catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
TLS2_k127_5041515_3	717785.HYPMC_4695	2.019e-79	276.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2TTB3@28211|Alphaproteobacteria,3N70D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
TLS2_k127_5041515_4	1267005.KB911255_gene2601	1.284e-77	264.0	COG0431@1|root,COG0431@2|Bacteria,1RH7F@1224|Proteobacteria,2TUD4@28211|Alphaproteobacteria,3N79T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	NADPH-dependent FMN reductase	MA20_24580	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS2_k127_5041515_6	96561.Dole_3115	4.806e-29	126.0	COG0457@1|root,COG0457@2|Bacteria,1N5M0@1224|Proteobacteria,42U23@68525|delta/epsilon subdivisions,2WQ2H@28221|Deltaproteobacteria,2MKG5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
TLS2_k127_5041515_2	1535287.JP74_07870	2.216e-80	285.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,3N61M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S1C family	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
TLS2_k127_5056304_0	1429916.X566_16185	1.007e-176	563.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria,3JQQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_5056304_5	1267005.KB911261_gene2255	1.046e-98	324.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2TQZM@28211|Alphaproteobacteria,3N6U1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
TLS2_k127_5056304_2	717785.HYPMC_0309	8.633e-103	347.0	COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,2TRZP@28211|Alphaproteobacteria,3N7AY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	nah	-	1.14.13.1	ko:K00480	ko00621,ko00624,ko00626,ko01100,ko01120,ko01220,map00621,map00624,map00626,map01100,map01120,map01220	-	R00818,R05632,R06915,R06936,R06939	RC00389	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
TLS2_k127_5056304_6	1267005.KB911256_gene1745	9.99e-34	133.0	COG4391@1|root,COG4391@2|Bacteria,1MZNK@1224|Proteobacteria,2UD0H@28211|Alphaproteobacteria,3N77N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Zinc-finger domain	MA20_32275	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
TLS2_k127_5056304_4	1267005.KB911256_gene1744	1.92e-101	336.0	COG0596@1|root,COG0596@2|Bacteria,1MW2P@1224|Proteobacteria,2TSS3@28211|Alphaproteobacteria,3N6PF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Alpha beta hydrolase	MA20_32265	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_5056304_3	670307.HYPDE_30383	1.432e-102	347.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2TQUB@28211|Alphaproteobacteria,3N7AB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	permease YjgP YjgQ family protein	MA20_28210	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TLS2_k127_5056304_1	1267005.KB911263_gene1278	6.626e-113	385.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2TR76@28211|Alphaproteobacteria,3N79Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	permease YjgP YjgQ	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TLS2_k127_5098224_42	1244869.H261_03828	1.028e-08	58.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,2JPK2@204441|Rhodospirillales	204441|Rhodospirillales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TLS2_k127_5098224_13	1121106.JQKB01000068_gene1689	3.963e-126	412.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria,2JQG4@204441|Rhodospirillales	204441|Rhodospirillales	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	gyaR	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_5098224_4	1205680.CAKO01000008_gene4082	5.623e-185	591.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria,2JQ5F@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_5098224_1	439496.RBY4I_2807	2.59e-277	868.0	COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,2TRVM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	phosphatase	-	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
TLS2_k127_5098224_2	670307.HYPDE_23893	3.743e-205	650.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,3N61M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S1C family	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
TLS2_k127_5098224_15	582899.Hden_2451	7.501e-118	383.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2TR06@28211|Alphaproteobacteria,3N6I5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS2_k127_5098224_11	1267005.KB911256_gene1947	6.479e-133	431.0	COG1511@1|root,COG1511@2|Bacteria,1NYJB@1224|Proteobacteria,2TSX0@28211|Alphaproteobacteria,3N6Q5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	MotA TolQ ExbB proton channel family	MA20_18055	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
TLS2_k127_5098224_8	1267005.KB911256_gene1946	8.076e-151	483.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,2TQKZ@28211|Alphaproteobacteria,3N6EY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	OmpA family	MA20_18060	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
TLS2_k127_5098224_30	1267005.KB911257_gene760	1.564e-55	199.0	COG0735@1|root,COG0735@2|Bacteria,1RH58@1224|Proteobacteria,2U75R@28211|Alphaproteobacteria,3N70R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Belongs to the Fur family	-	-	-	ko:K09826	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_5098224_17	1207063.P24_10720	1.017e-103	344.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria,2JPP5@204441|Rhodospirillales	204441|Rhodospirillales	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_5098224_41	331869.BAL199_24709	2.842e-25	107.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria,4BPUP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_5098224_12	582899.Hden_2659	1.533e-131	432.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2TU5X@28211|Alphaproteobacteria,3N81U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
TLS2_k127_5098224_36	420324.KI911965_gene1186	5.891e-44	163.0	COG0251@1|root,COG0251@2|Bacteria,1N35M@1224|Proteobacteria,2UE53@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS2_k127_5098224_6	1040989.AWZU01000037_gene7280	4.5e-166	526.0	COG3386@1|root,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,2TSXG@28211|Alphaproteobacteria,3JV1I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	SMP-30/Gluconolaconase/LRE-like region	-	-	3.1.1.17	ko:K01053,ko:K14274	ko00030,ko00040,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00040,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02427,R02933,R03751	RC00537,RC00713,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
TLS2_k127_5098224_10	1205680.CAKO01000002_gene2212	5.749e-143	463.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TU1G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1062 Zn-dependent alcohol dehydrogenases, class III	-	-	1.1.1.1,1.1.1.284	ko:K00001,ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_5098224_24	909943.HIMB100_00004170	1.304e-85	291.0	COG1838@1|root,COG1838@2|Bacteria,1MVNG@1224|Proteobacteria,2TTHD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1838 Tartrate dehydratase beta subunit Fumarate hydratase class I, C-terminal domain	ttdB	-	4.2.1.32	ko:K03780	ko00630,map00630	-	R00339	RC01382	ko00000,ko00001,ko01000	-	-	-	Fumerase_C
TLS2_k127_5098224_39	670307.HYPDE_24598	2.173e-27	117.0	2E3E3@1|root,33BAN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5098224_35	1380355.JNIJ01000020_gene3837	2.978e-44	173.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,2TRGG@28211|Alphaproteobacteria,3JQPT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
TLS2_k127_5098224_27	717785.HYPMC_2515	3.427e-60	224.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,2TUXV@28211|Alphaproteobacteria,3N74N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS2_k127_5098224_0	1245469.S58_51050	3.342e-298	923.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TSME@28211|Alphaproteobacteria,3JQSX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Gamma-glutamyltranspeptidase	MA20_16750	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_5098224_19	1417296.U879_08045	4.967e-97	328.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,2TVK0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,FAD_oxidored,Lycopene_cycl,Trp_halogenase
TLS2_k127_5098224_25	717785.HYPMC_0918	6.738e-79	269.0	COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,2TV7J@28211|Alphaproteobacteria,3N6R6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
TLS2_k127_5098224_16	1123504.JQKD01000012_gene1289	3.792e-104	346.0	COG1028@1|root,COG1028@2|Bacteria,1R6D6@1224|Proteobacteria	1224|Proteobacteria	IQ	short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_5098224_34	670307.HYPDE_37228	1.462e-48	178.0	2CN5Z@1|root,32SGB@2|Bacteria,1N1FB@1224|Proteobacteria,2UBV1@28211|Alphaproteobacteria,3N754@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2948)	MA20_21100	-	-	-	-	-	-	-	-	-	-	-	DUF2948
TLS2_k127_5098224_3	1267005.KB911265_gene3651	4.172e-191	605.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2TSBN@28211|Alphaproteobacteria,3N658@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
TLS2_k127_5098224_28	1267005.KB911265_gene3652	5.194e-59	210.0	COG5328@1|root,COG5328@2|Bacteria,1RA93@1224|Proteobacteria,2U741@28211|Alphaproteobacteria,3N712@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Uncharacterised protein family (UPF0262)	MA20_21090	-	-	-	-	-	-	-	-	-	-	-	UPF0262
TLS2_k127_5098224_31	648757.Rvan_3544	2.582e-54	194.0	COG0394@1|root,COG0394@2|Bacteria,1RANV@1224|Proteobacteria,2U5EE@28211|Alphaproteobacteria,3N8V5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Low molecular weight phosphatase family	MA20_21085	-	1.20.4.1,3.1.3.48	ko:K01104,ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS2_k127_5098224_29	1100720.ALKN01000028_gene2596	8.32e-59	209.0	COG2128@1|root,COG2128@2|Bacteria,1NFKC@1224|Proteobacteria,2VR28@28216|Betaproteobacteria,4AF47@80864|Comamonadaceae	28216|Betaproteobacteria	S	carboxymuconolactone decarboxylase	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
TLS2_k127_5098224_33	1131814.JAFO01000001_gene3366	2.786e-50	182.0	COG1917@1|root,COG1917@2|Bacteria,1RAGP@1224|Proteobacteria,2U5F3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ChrR Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
TLS2_k127_5098224_45	1230476.C207_07025	7.426e-05	52.0	2ED53@1|root,3371U@2|Bacteria,1MUY2@1224|Proteobacteria,2U1AB@28211|Alphaproteobacteria,3JSXY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5098224_14	670307.HYPDE_24478	3.528e-122	403.0	COG0438@1|root,COG0438@2|Bacteria,1MUTA@1224|Proteobacteria,2TSPN@28211|Alphaproteobacteria,3N859@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase 4-like	capM	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_5098224_22	582899.Hden_0389	9.69e-93	312.0	COG1073@1|root,COG1073@2|Bacteria,1MX88@1224|Proteobacteria,2TSRE@28211|Alphaproteobacteria,3N6T9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	MA20_24420	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,Hydrolase_4
TLS2_k127_5098224_37	1267005.KB911255_gene2466	2.03e-38	162.0	COG3064@1|root,COG3064@2|Bacteria,1R7WR@1224|Proteobacteria	1224|Proteobacteria	M	Membrane	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	DUF874,TonB_2
TLS2_k127_5098224_21	1267005.KB911255_gene2467	9.596e-95	320.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,2TRDY@28211|Alphaproteobacteria,3N6ME@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	GM	COG0451 Nucleoside-diphosphate-sugar epimerases	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_5098224_9	1381123.AYOD01000035_gene3606	1.881e-148	479.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,2TR5E@28211|Alphaproteobacteria,43GQ2@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16,HEAT_2
TLS2_k127_5098224_18	1424334.W822_19640	4.385e-102	343.0	COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria,2VIKK@28216|Betaproteobacteria,3T6I6@506|Alcaligenaceae	28216|Betaproteobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_5098224_20	1120956.JHZK01000006_gene615	6.414e-97	324.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,1JPKX@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_C_2,GST_N,GST_N_3
TLS2_k127_5098224_26	1267005.KB911256_gene1743	3.278e-70	244.0	COG3921@1|root,COG3921@2|Bacteria,1N3WR@1224|Proteobacteria,2U1ZC@28211|Alphaproteobacteria,3N8P2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Extensin family	-	-	-	-	-	-	-	-	-	-	-	-	Extensin-like_C
TLS2_k127_5098224_32	1245469.S58_09370	5.649e-51	192.0	28NCK@1|root,2ZBFJ@2|Bacteria,1R66Q@1224|Proteobacteria,2U3FV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5098224_5	1267005.KB911260_gene3478	3.746e-176	568.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2TT58@28211|Alphaproteobacteria,3N6K6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	-	-	-	-	-	-	-	-	-	-	Carb_kinase,YjeF_N
TLS2_k127_5098224_44	1122613.ATUP01000001_gene2111	1.297e-06	52.0	28YFD@1|root,2ZK9R@2|Bacteria,1P8FC@1224|Proteobacteria,2UYQI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5098224_38	216594.MMAR_4165	2.339e-34	139.0	COG0346@1|root,COG0346@2|Bacteria,2II0X@201174|Actinobacteria,239DP@1762|Mycobacteriaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	gloA_3	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_5098224_7	876269.ARWA01000001_gene2955	4.12e-156	499.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2TQT1@28211|Alphaproteobacteria,3N9UE@45404|Beijerinckiaceae	28211|Alphaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TLS2_k127_5098224_43	1131814.JAFO01000001_gene1987	1.562e-07	57.0	296FE@1|root,31B4W@2|Bacteria,1Q6WJ@1224|Proteobacteria,2VCZR@28211|Alphaproteobacteria,3F242@335928|Xanthobacteraceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5098224_23	1267005.KB911257_gene947	5.798e-88	304.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2TR46@28211|Alphaproteobacteria,3N6NS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8
TLS2_k127_5115036_14	1267005.KB911258_gene593	9.434e-73	252.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2TSC9@28211|Alphaproteobacteria,3N6ZA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
TLS2_k127_5115036_15	1267005.KB911258_gene594	1.45e-72	257.0	28MUE@1|root,2ZB2B@2|Bacteria,1N3YU@1224|Proteobacteria,2TUD9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
TLS2_k127_5115036_19	1205681.CALW02000067_gene599	5.838e-38	143.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2UC13@28211|Alphaproteobacteria,48U94@772|Bartonellaceae	28211|Alphaproteobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
TLS2_k127_5115036_17	582899.Hden_1716	2.633e-56	207.0	COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2U767@28211|Alphaproteobacteria,3N6ZP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
TLS2_k127_5115036_23	1439940.BAY1663_02314	6.704e-07	57.0	2EIG1@1|root,33C7D@2|Bacteria,1NNA9@1224|Proteobacteria,1SH4C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5115036_0	1267005.KB911256_gene2031	5.881e-291	899.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,3N6GJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS2_k127_5115036_18	1267005.KB911256_gene2030	2.091e-48	175.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,3N72T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TLS2_k127_5115036_2	1267005.KB911255_gene2883	2.082e-140	456.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TS06@28211|Alphaproteobacteria,3N640@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class I and II	aspB	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS2_k127_5115036_13	488538.SAR116_1471	7.979e-83	286.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
TLS2_k127_5115036_10	1267005.KB911255_gene2966	3.343e-90	303.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2U73X@28211|Alphaproteobacteria,3N6VY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
TLS2_k127_5115036_12	1267005.KB911255_gene2969	1.658e-83	280.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,2TTA8@28211|Alphaproteobacteria,3N6R5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	May be involved in the biosynthesis of molybdopterin	moaB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
TLS2_k127_5115036_7	1267005.KB911255_gene2584	2.885e-100	329.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2TR3M@28211|Alphaproteobacteria,3N6JY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	HNH endonuclease	MA20_20605	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
TLS2_k127_5115036_8	331869.BAL199_18128	3.205e-95	320.0	COG3836@1|root,COG3836@2|Bacteria,1RCR7@1224|Proteobacteria,2U59U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	HpcH/HpaI aldolase/citrate lyase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
TLS2_k127_5115036_16	1380391.JIAS01000013_gene3841	9.67e-58	210.0	COG0730@1|root,COG0730@2|Bacteria,1RDKW@1224|Proteobacteria,2TQP3@28211|Alphaproteobacteria,2JSF0@204441|Rhodospirillales	204441|Rhodospirillales	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
TLS2_k127_5115036_6	1267005.KB911257_gene700	9.326e-105	350.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,2TS2U@28211|Alphaproteobacteria,3N6QK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS2_k127_5115036_11	1267005.KB911257_gene702	3.653e-88	306.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,2TS2U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	NU	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS2_k127_5115036_20	1298867.AUES01000030_gene2459	3.483e-30	123.0	COG3631@1|root,COG3631@2|Bacteria,1P16W@1224|Proteobacteria,2UUSD@28211|Alphaproteobacteria,3K519@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS2_k127_5115036_1	717785.HYPMC_4527	8.212e-203	637.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,3N66U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	6.2.1.5,6.2.1.9	ko:K01903,ko:K14067	ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00346,M00374,M00620	R00405,R01256,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
TLS2_k127_5115036_9	1121861.KB899916_gene1771	1.599e-94	317.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.1.1.41,4.2.1.17	ko:K01692,ko:K11264	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R00923,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00097,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_5115036_5	1510531.JQJJ01000009_gene801	5.51e-117	385.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria,3JQWB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Nitronate monooxygenase	MA20_36475	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
TLS2_k127_5115036_3	460265.Mnod_1313	2.126e-131	428.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TR3G@28211|Alphaproteobacteria,1JRBP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM aldo keto reductase	MA20_21005	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
TLS2_k127_5115036_4	1411123.JQNH01000001_gene3198	9.123e-129	420.0	COG1063@1|root,COG1063@2|Bacteria,1MW7C@1224|Proteobacteria,2U09B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	AlaDh_PNT_C
TLS2_k127_5118385_1	1411123.JQNH01000001_gene2532	1.187e-163	521.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,2TSIV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	fructose-bisphosphate aldolase	fbaB	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
TLS2_k127_5118385_3	1121861.KB899910_gene710	5.518e-90	299.0	COG4275@1|root,COG4275@2|Bacteria,1R8GI@1224|Proteobacteria,2U4KJ@28211|Alphaproteobacteria,2JVGA@204441|Rhodospirillales	204441|Rhodospirillales	S	ChrB domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5118385_0	670307.HYPDE_26083	2.272e-182	578.0	COG0477@1|root,COG2814@2|Bacteria,1MXPM@1224|Proteobacteria,2TSB9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_5118385_4	460265.Mnod_0963	4.291e-18	96.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2UBUP@28211|Alphaproteobacteria,1JVPN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TLS2_k127_5118385_2	639283.Snov_2526	8.139e-114	376.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TS46@28211|Alphaproteobacteria,3F08W@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
TLS2_k127_5146993_3	224911.27352260	5.888e-59	205.0	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,2U0E0@28211|Alphaproteobacteria,3JS2D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Beta-lactamase	MA20_27655	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_5146993_0	582899.Hden_2551	8.033e-113	377.0	COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,2TRM3@28211|Alphaproteobacteria,3N6ST@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
TLS2_k127_5146993_2	1089553.Tph_c14800	7.919e-76	273.0	COG2865@1|root,COG2865@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2
TLS2_k127_5146993_1	717785.HYPMC_4156	2.389e-90	302.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2TQVX@28211|Alphaproteobacteria,3N678@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	endonuclease III	mutY	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
TLS2_k127_5210928_0	582899.Hden_3281	6.211e-169	538.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2TRJS@28211|Alphaproteobacteria,3N67J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
TLS2_k127_5210928_4	1408419.JHYG01000002_gene1095	1.827e-44	165.0	COG0346@1|root,COG0346@2|Bacteria,1N1T7@1224|Proteobacteria,2UBWG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_5210928_6	1449063.JMLS01000009_gene2270	3.434e-22	105.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_5210928_1	1267005.KB911257_gene1013	3.665e-135	447.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2TQZW@28211|Alphaproteobacteria,3N63E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
TLS2_k127_5210928_3	1380391.JIAS01000019_gene1349	3.449e-89	300.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2U62V@28211|Alphaproteobacteria,2JRXQ@204441|Rhodospirillales	204441|Rhodospirillales	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_5210928_2	1267005.KB911255_gene2438	1.593e-89	303.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,3N6SN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
TLS2_k127_5210928_5	1121033.AUCF01000004_gene4995	8.833e-37	144.0	COG3394@1|root,COG3394@2|Bacteria,1MX3P@1224|Proteobacteria,2TV3U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	PFAM YdjC family protein	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
TLS2_k127_5269206_3	998674.ATTE01000001_gene1573	2.714e-132	427.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria,461TK@72273|Thiotrichales	72273|Thiotrichales	E	Peptidase family M28	-	-	3.5.3.9	ko:K02083	ko00230,ko01120,map00230,map01120	-	R02423	RC00064	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_5269206_1	1211115.ALIQ01000095_gene273	3.137e-147	479.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2TSQI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0665 Glycine D-amino acid oxidases (deaminating)	-	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO
TLS2_k127_5269206_5	1123229.AUBC01000029_gene3530	2.128e-114	377.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2TRDC@28211|Alphaproteobacteria,3JUMH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
TLS2_k127_5269206_0	1057002.KB905370_gene3282	2.474e-190	601.0	COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2TRB8@28211|Alphaproteobacteria,4B8F7@82115|Rhizobiaceae	28211|Alphaproteobacteria	CH	4-hydroxybenzoate	pobA	GO:0000166,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016705,GO:0016709,GO:0018659,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
TLS2_k127_5269206_4	331869.BAL199_27791	1.33e-116	379.0	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2TU2C@28211|Alphaproteobacteria,4BRWG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Protocatechuate 3,4-dioxygenase beta subunit N terminal	pcaH	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,PCDO_beta_N
TLS2_k127_5269206_6	331869.BAL199_27796	8.31e-83	280.0	COG3485@1|root,COG3485@2|Bacteria,1MV3B@1224|Proteobacteria,2TTZJ@28211|Alphaproteobacteria,4BS9H@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Dioxygenase	pcaG	-	1.13.11.3	ko:K00448	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
TLS2_k127_5269206_2	1121106.JQKB01000019_gene2833	7.062e-138	454.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,2JQU6@204441|Rhodospirillales	204441|Rhodospirillales	J	COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
TLS2_k127_5269206_7	1205680.CAKO01000004_gene3679	2.061e-76	258.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRIH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	MA20_16365	-	4.2.1.149	ko:K08299	-	-	R10675	RC01095	ko00000,ko01000	-	-	-	ECH_1
TLS2_k127_5270086_10	1038859.AXAU01000028_gene23	8.138e-35	147.0	COG3889@1|root,COG3889@2|Bacteria,1R6EI@1224|Proteobacteria,2UQR6@28211|Alphaproteobacteria,3K2HR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5270086_0	1380355.JNIJ01000050_gene128	1.474e-213	671.0	COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,2TTAH@28211|Alphaproteobacteria,3JZY2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_5270086_14	1088721.NSU_3670	7.588e-07	51.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,2K0YQ@204457|Sphingomonadales	204457|Sphingomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_5270086_7	648757.Rvan_3366	2.527e-93	313.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,2TUXV@28211|Alphaproteobacteria,3N74N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS2_k127_5270086_17	460265.Mnod_4940	0.000577	52.0	COG3904@1|root,COG3904@2|Bacteria,1QY16@1224|Proteobacteria,2TXF8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	periplasmic protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5270086_11	1185652.USDA257_c48010	3.605e-29	133.0	COG3904@1|root,COG3904@2|Bacteria,1Q6DI@1224|Proteobacteria,2VCJ8@28211|Alphaproteobacteria,4BI6Z@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	periplasmic protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5270086_3	375451.RD1_2187	1.221e-156	505.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2P1JP@2433|Roseobacter	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
TLS2_k127_5270086_12	1123366.TH3_20097	7.44e-26	115.0	COG3090@1|root,COG3090@2|Bacteria,1RHM1@1224|Proteobacteria,2UAUW@28211|Alphaproteobacteria,2JZPW@204441|Rhodospirillales	204441|Rhodospirillales	G	COG3090 TRAP-type C4-dicarboxylate transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_5270086_5	1177928.TH2_19053	5.949e-112	372.0	COG1638@1|root,COG1638@2|Bacteria,1P3MK@1224|Proteobacteria,2TVQB@28211|Alphaproteobacteria,2JQ37@204441|Rhodospirillales	204441|Rhodospirillales	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
TLS2_k127_5270086_2	1297865.APJD01000007_gene1957	4.718e-175	559.0	COG0654@1|root,COG0654@2|Bacteria,1MXEW@1224|Proteobacteria,2TRRC@28211|Alphaproteobacteria,3JV1F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	MA20_42420	-	1.14.13.218	ko:K20940	ko00405,ko01130,map00405,map01130	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
TLS2_k127_5270086_4	1267005.KB911263_gene1362	2.428e-129	423.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2TRSV@28211|Alphaproteobacteria,3N681@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
TLS2_k127_5270086_8	648885.KB316283_gene3180	1.106e-66	231.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2U58D@28211|Alphaproteobacteria,1JTIV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
TLS2_k127_5270086_13	1267005.KB911263_gene1355	5.499e-16	79.0	COG5481@1|root,COG5481@2|Bacteria,1NG9U@1224|Proteobacteria,2UFXJ@28211|Alphaproteobacteria,3N7EN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF465)	MA20_03740	-	-	-	-	-	-	-	-	-	-	-	DUF465
TLS2_k127_5270086_15	1123229.AUBC01000004_gene3075	2.868e-05	55.0	COG2010@1|root,COG2010@2|Bacteria,1NBAR@1224|Proteobacteria,2UHUQ@28211|Alphaproteobacteria,3K16V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	cycB	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
TLS2_k127_5270086_6	1267005.KB911256_gene1510	5.441e-102	345.0	COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,2TSVI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the hyi family	ygbM	-	5.3.1.22,5.3.1.35	ko:K01816,ko:K22131	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_5270086_1	1267005.KB911259_gene3875	9.057e-200	634.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria,3N6E0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
TLS2_k127_5270086_9	414684.RC1_0150	1.667e-40	157.0	COG3394@1|root,COG3394@2|Bacteria,1PP39@1224|Proteobacteria,2U2UW@28211|Alphaproteobacteria,2JSM3@204441|Rhodospirillales	204441|Rhodospirillales	G	YdjC-like protein	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
TLS2_k127_528749_3	1267005.KB911256_gene1775	3.525e-155	504.0	2C2CS@1|root,2Z7SK@2|Bacteria,1NCSN@1224|Proteobacteria,2U436@28211|Alphaproteobacteria,3N8HX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3754)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3754
TLS2_k127_528749_0	1082933.MEA186_06887	4.959e-226	737.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2TRX2@28211|Alphaproteobacteria,43IZG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
TLS2_k127_528749_8	1267005.KB911255_gene2880	2.946e-80	285.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria,3N6RA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Ami_3	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
TLS2_k127_528749_6	1007105.PT7_0669	1.59e-91	321.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2WGUW@28216|Betaproteobacteria,3T60B@506|Alcaligenaceae	28216|Betaproteobacteria	EGP	Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_528749_1	331869.BAL199_03564	4.826e-209	656.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria,4BR75@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_528749_10	1207063.P24_07231	2.778e-57	207.0	COG4665@1|root,COG4665@2|Bacteria,1QV7S@1224|Proteobacteria,2TWCP@28211|Alphaproteobacteria,2JWY5@204441|Rhodospirillales	204441|Rhodospirillales	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_528749_4	331869.BAL199_03574	1.106e-150	483.0	COG1638@1|root,COG1638@2|Bacteria,1PG0D@1224|Proteobacteria,2TTUQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_528749_5	1123229.AUBC01000016_gene4229	1.337e-108	372.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2TR37@28211|Alphaproteobacteria,3JVT9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Malate/L-lactate dehydrogenase	-	-	1.1.1.338	ko:K16844	ko00270,ko01120,map00270,map01120	-	R07137	RC00031	ko00000,ko00001,ko01000	-	-	-	Ldh_2
TLS2_k127_528749_2	1304275.C41B8_03561	3.794e-163	522.0	COG4948@1|root,COG4948@2|Bacteria,1MVFW@1224|Proteobacteria,1RYMG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	-	-	4.2.1.81	ko:K22209	-	-	-	-	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_528749_9	536019.Mesop_2445	2.04e-64	225.0	COG3981@1|root,COG3981@2|Bacteria,1RGGC@1224|Proteobacteria,2UAUM@28211|Alphaproteobacteria,43N6U@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
TLS2_k127_528749_7	1502851.FG93_02138	8.875e-86	285.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2TTDT@28211|Alphaproteobacteria,3JVQN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	garD	-	4.2.1.7,4.4.1.24	ko:K16846,ko:K16850	ko00040,ko00270,ko01100,map00040,map00270,map01100	M00631	R01540,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C
TLS2_k127_529295_9	1267005.KB911264_gene3203	1.521e-90	302.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,3N6PA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	1.1.1.53	ko:K00038	ko00140,ko01100,map00140,map01100	-	R04831,R04834,R04844,R04847	RC00139,RC01219,RC01220	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
TLS2_k127_529295_1	717785.HYPMC_2219	1.142e-196	623.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TQS7@28211|Alphaproteobacteria,3N6AJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_529295_19	1122132.AQYH01000018_gene1145	1.031e-11	77.0	COG3184@1|root,COG3184@2|Bacteria,1NGBK@1224|Proteobacteria,2UC5I@28211|Alphaproteobacteria,4BBKS@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2059)	-	-	-	ko:K09924	-	-	-	-	ko00000	-	-	-	DUF2059
TLS2_k127_529295_7	1267005.KB911260_gene3581	1.348e-105	347.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2TU68@28211|Alphaproteobacteria,3N6QX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
TLS2_k127_529295_8	1267005.KB911258_gene351	8.843e-100	331.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,3N7K2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
TLS2_k127_529295_15	648757.Rvan_0077	3.723e-37	148.0	COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2U5DW@28211|Alphaproteobacteria,3N8U2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS2_k127_529295_12	1121861.KB899925_gene2554	3.064e-79	272.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2TSWQ@28211|Alphaproteobacteria,2JQ14@204441|Rhodospirillales	204441|Rhodospirillales	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_529295_10	1207063.P24_11512	6.656e-84	295.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TR6T@28211|Alphaproteobacteria,2JQUS@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_529295_0	1205680.CAKO01000040_gene1071	1.501e-220	702.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,1MY1E@1224|Proteobacteria,2TTC6@28211|Alphaproteobacteria,2JQDN@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_529295_3	1205680.CAKO01000040_gene1070	2.77e-174	554.0	COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,2TTAH@28211|Alphaproteobacteria,2JQHT@204441|Rhodospirillales	204441|Rhodospirillales	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_529295_6	1174528.JH992898_gene3788	8.211e-121	409.0	COG2192@1|root,COG2192@2|Bacteria,1G1FV@1117|Cyanobacteria	1117|Cyanobacteria	O	carbamoyl transferase, NodU family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TLS2_k127_529295_4	670307.HYPDE_29873	4.482e-156	499.0	COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,2TSPE@28211|Alphaproteobacteria,3N66Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	fructose-1,6-bisphosphatase	glpX	-	3.1.3.11,3.1.3.37	ko:K02446,ko:K11532	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
TLS2_k127_529295_2	1121106.JQKB01000025_gene4106	2.02e-196	621.0	COG2141@1|root,COG2141@2|Bacteria,1MUVN@1224|Proteobacteria,2TR26@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	monooxygenase	MA20_06115	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_529295_20	1088721.NSU_1499	9.89e-07	55.0	2DM07@1|root,31400@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_529295_17	648757.Rvan_0078	2.075e-19	99.0	COG0393@1|root,COG0393@2|Bacteria	2|Bacteria	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
TLS2_k127_529295_5	1267005.KB911265_gene3637	9.386e-154	510.0	2C0EB@1|root,32R6V@2|Bacteria,1NTFI@1224|Proteobacteria,2UPQF@28211|Alphaproteobacteria,3N82A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_529295_13	1207063.P24_00920	1.212e-74	260.0	COG1024@1|root,COG1024@2|Bacteria,1PU1Q@1224|Proteobacteria,2TSW6@28211|Alphaproteobacteria,2JS2P@204441|Rhodospirillales	204441|Rhodospirillales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_529295_14	1121946.AUAX01000002_gene19	7.909e-62	221.0	2AP53@1|root,31E6R@2|Bacteria,2IPBQ@201174|Actinobacteria,4DD3T@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_529295_11	1267005.KB911257_gene868	6.853e-83	288.0	2F3UN@1|root,33WKV@2|Bacteria,1NVSH@1224|Proteobacteria,2US2K@28211|Alphaproteobacteria,3N8GE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_529295_21	929712.KI912613_gene3629	1.894e-06	53.0	COG0484@1|root,COG0484@2|Bacteria,2HPCA@201174|Actinobacteria,4CQQF@84995|Rubrobacteria	84995|Rubrobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
TLS2_k127_5313660_7	331869.BAL199_22262	5.98e-05	46.0	COG1893@1|root,COG1893@2|Bacteria,1QMH8@1224|Proteobacteria,2TSGW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5313660_3	1267005.KB911256_gene1913	4.889e-73	258.0	COG5400@1|root,COG5400@2|Bacteria,1RASG@1224|Proteobacteria,2U590@28211|Alphaproteobacteria,3N6YS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1134)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1134
TLS2_k127_5313660_4	1267005.KB911256_gene1914	8.584e-57	216.0	COG1196@1|root,COG1196@2|Bacteria,1QW5B@1224|Proteobacteria,2TWN5@28211|Alphaproteobacteria,3N7CD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5313660_0	1267005.KB911256_gene2080	1.552e-114	379.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2TR0M@28211|Alphaproteobacteria,3N6NG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
TLS2_k127_5313660_2	1267005.KB911255_gene3020	2.246e-84	287.0	COG3719@1|root,COG3719@2|Bacteria,1PTUN@1224|Proteobacteria,2TQUU@28211|Alphaproteobacteria,3N8MD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the RNase T2 family	rns	-	3.1.27.1,3.1.27.6	ko:K01166,ko:K01169	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_T2
TLS2_k127_5313660_1	670307.HYPDE_22738	3.667e-107	358.0	COG3509@1|root,COG3509@2|Bacteria,1NTIV@1224|Proteobacteria,2U5IP@28211|Alphaproteobacteria,3N7IT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
TLS2_k127_5313660_5	1547437.LL06_06570	2.689e-56	207.0	COG0847@1|root,COG2905@1|root,COG0847@2|Bacteria,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2TRZC@28211|Alphaproteobacteria,43HZS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	LT	DNA polymerase III, epsilon subunit	-	-	2.7.7.7	ko:K02342,ko:K07182	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	CBS,DUF294,DUF294_C,RNase_T
TLS2_k127_5374194_0	1267005.KB911263_gene1270	3.683e-234	758.0	COG1196@1|root,COG1196@2|Bacteria,1MVEP@1224|Proteobacteria,2TR50@28211|Alphaproteobacteria,3N6WD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	Apolipoprotein
TLS2_k127_5374194_7	717785.HYPMC_1911	1.218e-16	87.0	COG2198@1|root,COG2198@2|Bacteria,1RI91@1224|Proteobacteria,2UGE0@28211|Alphaproteobacteria,3N7GC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	Hpt
TLS2_k127_5374194_3	316056.RPC_1383	7.575e-42	162.0	COG1051@1|root,COG1051@2|Bacteria,1N0YW@1224|Proteobacteria,2UC2E@28211|Alphaproteobacteria,3JY9M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Nudix hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_5374194_4	1267005.KB911255_gene2527	6.946e-37	141.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2UBRU@28211|Alphaproteobacteria,3N72A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
TLS2_k127_5374194_5	670307.HYPDE_24368	3.715e-29	119.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,3N78I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_5374194_1	1267005.KB911256_gene1487	3.586e-155	495.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2TR4Y@28211|Alphaproteobacteria,3N64F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
TLS2_k127_5374194_2	717785.HYPMC_4142	1.184e-113	375.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TQZP@28211|Alphaproteobacteria,3N6QM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	OU	Peptidase S49	sohB	-	-	ko:K04773,ko:K04774	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TLS2_k127_5374194_6	582899.Hden_1290	4.784e-23	106.0	COG1399@1|root,COG1399@2|Bacteria,1Q3HX@1224|Proteobacteria,2VABC@28211|Alphaproteobacteria,3N7EK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized ACR, COG1399	-	-	-	-	-	-	-	-	-	-	-	-	DUF177
TLS2_k127_5422319_10	1131814.JAFO01000001_gene1038	4.292e-60	216.0	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2TV0F@28211|Alphaproteobacteria,3F138@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	Crp-like helix-turn-helix domain	ftrB	-	-	ko:K13642	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_5422319_7	1038859.AXAU01000003_gene6202	1.28e-117	396.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,3JU16@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_5422319_6	1380355.JNIJ01000001_gene3988	1.068e-122	398.0	COG0411@1|root,COG0411@2|Bacteria,1NP6N@1224|Proteobacteria,2U27F@28211|Alphaproteobacteria,3K5XU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_5422319_2	1038859.AXAU01000003_gene6200	8.053e-186	587.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,3JW7Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_5422319_5	1038859.AXAU01000003_gene6199	2.28e-158	507.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,3JX26@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_5422319_1	1038859.AXAU01000003_gene6198	3.31e-202	635.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,3JXYC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_5422319_0	1333998.M2A_2717	2.114e-215	677.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,4BRSC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	MA20_17005	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_5422319_4	526227.Mesil_2412	1.974e-173	556.0	COG0665@1|root,COG0665@2|Bacteria,1WI96@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS2_k127_5422319_15	426117.M446_2386	8.81e-12	75.0	COG4960@1|root,COG4960@2|Bacteria,1RAYG@1224|Proteobacteria,2TSVX@28211|Alphaproteobacteria,1JTRX@119045|Methylobacteriaceae	28211|Alphaproteobacteria	OU	PFAM peptidase A24A prepilin type IV	cpaA	-	3.4.23.43	ko:K02278	-	-	-	-	ko00000,ko01000,ko02035,ko02044	-	-	-	Peptidase_A24
TLS2_k127_5422319_8	1282876.BAOK01000001_gene3387	3.762e-84	298.0	COG4961@1|root,COG4961@2|Bacteria,1MWXU@1224|Proteobacteria,2TRQP@28211|Alphaproteobacteria,4BQFA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad,VWA
TLS2_k127_5422319_13	1411123.JQNH01000001_gene3681	2.687e-25	114.0	COG3063@1|root,COG3063@2|Bacteria,1R6IJ@1224|Proteobacteria,2TTCB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	NU	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
TLS2_k127_5422319_11	1411123.JQNH01000001_gene3682	1.855e-54	205.0	COG2064@1|root,COG2064@2|Bacteria,1RF53@1224|Proteobacteria,2U0NI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	NU	Flp pilus assembly protein TadC	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_5422319_12	1040983.AXAE01000030_gene6205	6.496e-48	185.0	COG4965@1|root,COG4965@2|Bacteria,1RDCN@1224|Proteobacteria,2VG2R@28211|Alphaproteobacteria,43RN6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	Type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_5422319_3	460265.Mnod_2569	4.799e-176	563.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2TRNT@28211|Alphaproteobacteria,1JSMZ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	U	PFAM type II secretion system protein E	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS2_k127_5422319_9	648757.Rvan_3402	3.625e-64	235.0	COG4963@1|root,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2TUDS@28211|Alphaproteobacteria,3N6AI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	AAA domain	minD	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31
TLS2_k127_5422319_14	648757.Rvan_3403	1.147e-13	75.0	2FBKV@1|root,343S1@2|Bacteria,1RE31@1224|Proteobacteria,2U8H4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5479202_7	1230476.C207_03544	5.068e-86	292.0	COG1028@1|root,COG1028@2|Bacteria,1MX6D@1224|Proteobacteria,2TV8J@28211|Alphaproteobacteria,3JWDK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_5479202_4	1205680.CAKO01000038_gene1937	8.271e-144	467.0	COG1804@1|root,COG1804@2|Bacteria,1MWPB@1224|Proteobacteria,2U1YE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	carnitine dehydratase	MA20_04610	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS2_k127_5479202_6	1187851.A33M_4106	8.081e-94	316.0	COG2220@1|root,COG2220@2|Bacteria,1NVME@1224|Proteobacteria,2U180@28211|Alphaproteobacteria,3FD37@34008|Rhodovulum	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
TLS2_k127_5479202_9	235985.BBPN01000006_gene3590	2.264e-57	209.0	COG0483@1|root,COG0483@2|Bacteria,2GP74@201174|Actinobacteria,2NI0Y@228398|Streptacidiphilus	201174|Actinobacteria	G	Inositol monophosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Inositol_P
TLS2_k127_5479202_3	1121106.JQKB01000007_gene1038	6.498e-144	464.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_5479202_2	1205680.CAKO01000038_gene1624	1.165e-225	712.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,2JR2A@204441|Rhodospirillales	204441|Rhodospirillales	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS2_k127_5479202_0	1267005.KB911257_gene1076	4.095e-267	842.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2TR2R@28211|Alphaproteobacteria,3N6A8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	penicillin-binding protein	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
TLS2_k127_5479202_5	935548.KI912159_gene4112	3.28e-95	323.0	COG3739@1|root,COG3739@2|Bacteria,1PMEC@1224|Proteobacteria,2TRGD@28211|Alphaproteobacteria,43I0R@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF817)	-	-	-	-	-	-	-	-	-	-	-	-	DUF817
TLS2_k127_5479202_8	1040982.AXAL01000011_gene1066	1.001e-73	264.0	COG3233@1|root,COG3459@1|root,COG3233@2|Bacteria,COG3459@2|Bacteria,1QUXD@1224|Proteobacteria,2TXWR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Protein of unknown function (DUF3131)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3131
TLS2_k127_5479202_1	1173021.ALWA01000038_gene1761	4.67e-260	841.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,1G68R@1117|Cyanobacteria	1117|Cyanobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_5498080_13	670307.HYPDE_36463	2.388e-96	322.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria,3N66F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TLS2_k127_5498080_10	1267005.KB911257_gene857	7.521e-120	396.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2TTQ4@28211|Alphaproteobacteria,3N73Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Histidyl-tRNA synthetase	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
TLS2_k127_5498080_14	1267005.KB911257_gene856	9.242e-89	300.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2TT0H@28211|Alphaproteobacteria,3N6M7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
TLS2_k127_5498080_19	1267005.KB911255_gene2935	4.114e-45	167.0	COG5349@1|root,COG5349@2|Bacteria,1N0WU@1224|Proteobacteria,2UCE7@28211|Alphaproteobacteria,3N92J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
TLS2_k127_5498080_17	1267005.KB911255_gene2936	2.562e-61	220.0	COG3346@1|root,COG3346@2|Bacteria,1MWWG@1224|Proteobacteria,2U0N5@28211|Alphaproteobacteria,3N7AI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	SURF1 family	surf1	GO:0006996,GO:0007005,GO:0008150,GO:0008535,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0033108,GO:0033617,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
TLS2_k127_5498080_12	391735.Veis_1585	1.944e-117	398.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2VJ77@28216|Betaproteobacteria,4ABI1@80864|Comamonadaceae	28216|Betaproteobacteria	S	MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
TLS2_k127_5498080_9	420324.KI911970_gene1630	5.822e-134	435.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,1JR8B@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EP	Belongs to the ABC transporter superfamily	dppD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_5498080_7	864069.MicloDRAFT_00053950	6.027e-135	451.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,1JR3M@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_5498080_3	1502851.FG93_05665	1.417e-195	629.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,3JS99@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_5498080_8	1510531.JQJJ01000009_gene914	1.315e-134	436.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,3JUIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_5498080_11	420324.KI911970_gene1621	1.262e-117	398.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VETJ@28211|Alphaproteobacteria,1JTQP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_5498080_15	670307.HYPDE_28088	4.24e-82	281.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2TUG7@28211|Alphaproteobacteria,3N6S3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS2_k127_5498080_20	1197906.CAJQ02000015_gene218	2.241e-29	135.0	2A70E@1|root,30VVK@2|Bacteria,1NMRD@1224|Proteobacteria,2VCC0@28211|Alphaproteobacteria,3K3E0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4189
TLS2_k127_5498080_2	1205680.CAKO01000029_gene5065	1.434e-209	661.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,2JPCY@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1960 Acyl-CoA dehydrogenases	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_5498080_18	717785.HYPMC_4586	8.495e-58	207.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2TVBT@28211|Alphaproteobacteria,3N73R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
TLS2_k127_5498080_16	582899.Hden_3251	6.32e-82	278.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2TUSG@28211|Alphaproteobacteria,3N6WW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
TLS2_k127_5498080_0	582899.Hden_2858	5.702e-277	864.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TQRZ@28211|Alphaproteobacteria,3N6FH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ABC transporter	yheS	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
TLS2_k127_5498080_4	582899.Hden_2604	4.375e-184	586.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,3N80G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the peptidase M16 family	MA20_05655	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_5498080_5	717785.HYPMC_3843	4.571e-171	550.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2TRMX@28211|Alphaproteobacteria,3N80X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Peptidase M16 inactive domain	MA20_05660	-	-	ko:K07263,ko:K07623	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_5498080_6	670307.HYPDE_36598	2.341e-163	526.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,3N7BY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Belongs to the GPI family	pgi	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
TLS2_k127_5498080_1	1267005.KB911255_gene2700	2.139e-223	708.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria,3N662@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
TLS2_k127_551989_0	1205680.CAKO01000002_gene2730	8.807e-200	624.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,2V6FU@28211|Alphaproteobacteria,2JQ7D@204441|Rhodospirillales	204441|Rhodospirillales	C	Nitrate reductase beta subunit	narH	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
TLS2_k127_551989_4	1205680.CAKO01000002_gene2731	3.573e-92	308.0	COG2180@1|root,COG2180@2|Bacteria,1MY4E@1224|Proteobacteria,2U19T@28211|Alphaproteobacteria,2JSPY@204441|Rhodospirillales	204441|Rhodospirillales	C	Nitrate reductase delta subunit	-	-	-	ko:K00373	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Nitrate_red_del
TLS2_k127_551989_3	1205680.CAKO01000002_gene2732	1.089e-117	385.0	COG2181@1|root,COG2181@2|Bacteria,1MXGZ@1224|Proteobacteria,2TTDB@28211|Alphaproteobacteria,2JR8E@204441|Rhodospirillales	204441|Rhodospirillales	C	nitrate reductase, gamma subunit	-	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
TLS2_k127_551989_5	1197906.CAJQ02000024_gene1376	1.549e-91	308.0	COG0760@1|root,COG0760@2|Bacteria,1RDD3@1224|Proteobacteria,2U3I3@28211|Alphaproteobacteria,3JVF3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3
TLS2_k127_551989_10	1038859.AXAU01000001_gene2658	8.488e-23	103.0	2E09K@1|root,32VX5@2|Bacteria,1N5Z5@1224|Proteobacteria,2UCIG@28211|Alphaproteobacteria,3JZVS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_551989_6	1411123.JQNH01000001_gene570	1.814e-79	273.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2TRPD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS2_k127_551989_8	398525.KB900701_gene7808	1.723e-38	152.0	COG1618@1|root,COG1618@2|Bacteria,1RHUK@1224|Proteobacteria,2U9YB@28211|Alphaproteobacteria,3JZN9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Protein of unknown function (DUF2478)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2478
TLS2_k127_551989_9	631454.N177_2411	1.972e-35	138.0	COG2832@1|root,COG2832@2|Bacteria,1N7BI@1224|Proteobacteria,2UFAC@28211|Alphaproteobacteria,1JPCV@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF454)	ybaN	-	-	ko:K09790	-	-	-	-	ko00000	-	-	-	DUF454
TLS2_k127_551989_2	1333998.M2A_0269	7.55e-130	428.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2TSQ2@28211|Alphaproteobacteria,4BQQ8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	NnrS protein	nnrS	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
TLS2_k127_551989_7	864051.BurJ1DRAFT_2134	9.795e-59	210.0	2CDHC@1|root,32RXT@2|Bacteria,1N2M3@1224|Proteobacteria,2VVI3@28216|Betaproteobacteria,1KP7T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_551989_1	316055.RPE_4563	4.378e-153	490.0	COG0697@1|root,COG0697@2|Bacteria,1N3FA@1224|Proteobacteria,2TTFI@28211|Alphaproteobacteria,3JW4B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp,EamA
TLS2_k127_551989_11	491916.RHECIAT_CH0003412	3.868e-14	83.0	COG2215@1|root,COG2215@2|Bacteria,1RKNX@1224|Proteobacteria,2UA5V@28211|Alphaproteobacteria,4BCRQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the NiCoT transporter (TC 2.A.52) family	-	-	-	-	-	-	-	-	-	-	-	-	NicO
TLS2_k127_551989_12	765912.Thimo_2659	3.824e-07	52.0	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1WY4B@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TLS2_k127_5571415_4	1207063.P24_05857	5.026e-215	685.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,2JQKH@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
TLS2_k127_5571415_0	1380355.JNIJ01000014_gene607	2.269e-313	966.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,3JR3Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EG	Dehydratase family	MA20_39205	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS2_k127_5571415_9	69279.BG36_04645	1.081e-74	261.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,2U85S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_5571415_6	1121106.JQKB01000017_gene4847	2.584e-114	373.0	COG2267@1|root,COG2267@2|Bacteria,1N9CI@1224|Proteobacteria,2UG67@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_5571415_3	1205680.CAKO01000029_gene5115	2.707e-234	730.0	COG2141@1|root,COG2141@2|Bacteria,1R7GC@1224|Proteobacteria,2U0DW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_5571415_1	1122962.AULH01000011_gene1062	1.222e-275	863.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2TZIX@28211|Alphaproteobacteria,36XNQ@31993|Methylocystaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	hyfB	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
TLS2_k127_5571415_5	1121861.KB899911_gene1294	1.932e-140	455.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,2U0GZ@28211|Alphaproteobacteria,2JQM4@204441|Rhodospirillales	204441|Rhodospirillales	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NADHdh
TLS2_k127_5571415_7	1122962.AULH01000011_gene1060	2.967e-90	317.0	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,2TUAC@28211|Alphaproteobacteria,36XJF@31993|Methylocystaceae	28211|Alphaproteobacteria	C	COG4237 Hydrogenase 4 membrane component (E)	hyfE	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
TLS2_k127_5571415_2	1041146.ATZB01000023_gene2665	5.115e-244	760.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,2TSRU@28211|Alphaproteobacteria,4BBJG@82115|Rhizobiaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	hyfF	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
TLS2_k127_5571415_8	1122962.AULH01000011_gene1058	2.192e-77	268.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,1QUBF@1224|Proteobacteria,2TRE0@28211|Alphaproteobacteria,36XY7@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	hycE	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
TLS2_k127_5599073_1	258594.RPA3082	1.01e-153	496.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria,3JSP4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Mycolic acid cyclopropane synthetase	cfa2	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS2_k127_5599073_0	582899.Hden_2298	3.842e-259	808.0	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,2TRC4@28211|Alphaproteobacteria,3N6G3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
TLS2_k127_5599073_2	1121124.JNIX01000007_gene263	5.012e-78	262.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,2U57X@28211|Alphaproteobacteria,2KGE5@204458|Caulobacterales	204458|Caulobacterales	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
TLS2_k127_5599073_3	1187851.A33M_0503	1.36e-71	246.0	COG1738@1|root,COG1738@2|Bacteria,1RDSF@1224|Proteobacteria	1224|Proteobacteria	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
TLS2_k127_5599073_4	582899.Hden_0902	3.263e-24	102.0	COG3832@1|root,COG3832@2|Bacteria,1RCZK@1224|Proteobacteria,2TV1V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Activator of Hsp90 ATPase 1 family protein	MA20_15105	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_5633513_1	1502851.FG93_04196	5.399e-98	325.0	COG2943@1|root,COG2943@2|Bacteria,1MVXZ@1224|Proteobacteria,2TQU8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	glucosyltransferase	-	-	-	ko:K03669	-	-	-	-	ko00000,ko01000,ko01003,ko02000	4.D.3.1.1	GT2	-	Glyco_trans_2_3,Glycos_transf_2
TLS2_k127_5633513_3	443598.AUFA01000003_gene2282	2.182e-22	98.0	COG5395@1|root,COG5395@2|Bacteria,1N0CF@1224|Proteobacteria,2UC5R@28211|Alphaproteobacteria,3JYQZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2306
TLS2_k127_5633513_4	1429916.X566_21045	1.559e-16	79.0	COG5395@1|root,COG5395@2|Bacteria,1N0CF@1224|Proteobacteria,2UC5R@28211|Alphaproteobacteria,3JYQZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2306
TLS2_k127_5633513_0	1267005.KB911265_gene3643	0.0	1345.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3N65D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	MA20_39335	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
TLS2_k127_5633513_2	717785.HYPMC_4192	1.003e-28	118.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,2U18A@28211|Alphaproteobacteria,3N7I5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
TLS2_k127_5649437_3	1267005.KB911255_gene2469	1.449e-55	202.0	COG0625@1|root,COG0625@2|Bacteria,1MXM4@1224|Proteobacteria,2TTXD@28211|Alphaproteobacteria,3N6WM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	glutathione S-transferase	gst	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_C_3,GST_N_3
TLS2_k127_5649437_2	1411123.JQNH01000001_gene2247	1.348e-90	310.0	COG2030@1|root,COG2030@2|Bacteria,1RIBV@1224|Proteobacteria,2U3XU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	PFAM MaoC domain protein dehydratase	MA20_05345	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
TLS2_k127_5649437_0	670307.HYPDE_33028	2.818e-193	616.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria,3N61B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	5-aminolevulinic acid synthase	hemA	-	2.3.1.37	ko:K00643	ko00260,ko00860,ko01100,ko01110,map00260,map00860,map01100,map01110	-	R00830	RC00004,RC02815	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_5649437_1	1267005.KB911261_gene2208	3.341e-118	397.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TT9M@28211|Alphaproteobacteria,3N6SF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	ubiH	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
TLS2_k127_5649437_5	1205680.CAKO01000038_gene1591	6.976e-28	121.0	2DMD4@1|root,32NV5@2|Bacteria,1RI0E@1224|Proteobacteria,2UA1F@28211|Alphaproteobacteria,2JZT3@204441|Rhodospirillales	204441|Rhodospirillales	S	Conserved hypothetical protein (Lin0512_fam)	-	-	-	-	-	-	-	-	-	-	-	-	Lin0512_fam
TLS2_k127_5649437_4	1121106.JQKB01000016_gene5355	9.993e-31	129.0	2AJ2R@1|root,319M2@2|Bacteria,1RJXB@1224|Proteobacteria,2UA6I@28211|Alphaproteobacteria,2JY06@204441|Rhodospirillales	204441|Rhodospirillales	S	Conserved hypothetical protein (Lin0512_fam)	-	-	-	-	-	-	-	-	-	-	-	-	Lin0512_fam
TLS2_k127_5655237_29	670307.HYPDE_30873	2.361e-60	216.0	COG1522@1|root,COG1522@2|Bacteria,1MXVU@1224|Proteobacteria,2TTCK@28211|Alphaproteobacteria,3N8GD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix ASNC type	lrp	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009889,GO:0009987,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0016054,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043201,GO:0043436,GO:0043565,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
TLS2_k127_5655237_16	1267005.KB911258_gene561	2.457e-103	348.0	COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,2TQWV@28211|Alphaproteobacteria,3N8H3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Mitochondrial fission ELM1	-	-	-	ko:K07276	-	-	-	-	ko00000	-	-	-	Mito_fiss_Elm1
TLS2_k127_5655237_31	717785.HYPMC_2402	6.979e-31	124.0	COG5447@1|root,COG5447@2|Bacteria,1N1KU@1224|Proteobacteria,2UCBQ@28211|Alphaproteobacteria,3N7DI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1491)	MA20_15690	-	-	-	-	-	-	-	-	-	-	-	DUF1491
TLS2_k127_5655237_21	1297865.APJD01000004_gene5378	1.858e-79	283.0	COG4637@1|root,COG4637@2|Bacteria,1ND40@1224|Proteobacteria,2TTJW@28211|Alphaproteobacteria,3JW27@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,AAA_21
TLS2_k127_5655237_14	1038860.AXAP01000024_gene7529	8.043e-106	349.0	COG0451@1|root,COG0451@2|Bacteria,1MWVE@1224|Proteobacteria,2TS8F@28211|Alphaproteobacteria,3JU8F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	MA20_16995	-	1.1.1.203	ko:K18981	ko00053,map00053	-	R10841	RC00066	ko00000,ko00001,ko01000	-	-	-	Epimerase
TLS2_k127_5655237_9	1040989.AWZU01000019_gene1857	6.633e-150	484.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2TR6I@28211|Alphaproteobacteria,3JS9H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Peptidase family M20/M25/M40	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_5655237_34	670307.HYPDE_36623	0.0008513	51.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,3N67I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
TLS2_k127_5655237_17	717785.HYPMC_1908	4.645e-98	336.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2U5H1@28211|Alphaproteobacteria,3N73D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	EGP	Nucleoside H+ symporter	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
TLS2_k127_5655237_11	639283.Snov_2113	2.735e-112	374.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,3EY8E@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	tdcB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006520,GO:0006563,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016841,GO:0016853,GO:0016854,GO:0016855,GO:0017144,GO:0018249,GO:0019538,GO:0019752,GO:0019842,GO:0030170,GO:0030378,GO:0030848,GO:0036094,GO:0036211,GO:0036361,GO:0042219,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046416,GO:0046437,GO:0046872,GO:0047661,GO:0048037,GO:0050662,GO:0070178,GO:0070179,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_5655237_0	1267005.KB911259_gene3866	2.959e-224	701.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2TQWH@28211|Alphaproteobacteria,3N67C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_5655237_18	1411123.JQNH01000001_gene1859	1.099e-93	314.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TSPM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase	MA20_43195	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_5655237_2	331869.BAL199_00590	1.885e-203	642.0	COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2TTUB@28211|Alphaproteobacteria,4BRJR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8,TAT_signal
TLS2_k127_5655237_8	1037409.BJ6T_87400	6.45e-151	486.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TZRR@28211|Alphaproteobacteria,3JTDV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_5655237_5	1380355.JNIJ01000029_gene3096	2.135e-174	554.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2U0UX@28211|Alphaproteobacteria,3JWP8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_5655237_6	331869.BAL199_00605	6.268e-173	548.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
TLS2_k127_5655237_32	1304877.KI519399_gene3215	3.033e-22	100.0	2EIDG@1|root,33C4V@2|Bacteria,1N0P4@1224|Proteobacteria,2UC9K@28211|Alphaproteobacteria,3K073@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5655237_27	998674.ATTE01000001_gene2378	3.014e-65	229.0	COG1853@1|root,COG1853@2|Bacteria,1MUPP@1224|Proteobacteria,1RR4T@1236|Gammaproteobacteria,46116@72273|Thiotrichales	72273|Thiotrichales	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TLS2_k127_5655237_26	1267005.KB911258_gene338	3.384e-67	235.0	COG0778@1|root,COG0778@2|Bacteria,1PKUV@1224|Proteobacteria,2U5MZ@28211|Alphaproteobacteria,3N6WC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Nitroreductase family	MA20_31560	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_5655237_19	582899.Hden_1086	2.928e-83	302.0	COG2304@1|root,COG2304@2|Bacteria,1PBVT@1224|Proteobacteria,2U3NK@28211|Alphaproteobacteria,3N7CG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
TLS2_k127_5655237_25	670307.HYPDE_32253	2.544e-75	267.0	COG2304@1|root,COG2304@2|Bacteria,1QVE7@1224|Proteobacteria,2TWDA@28211|Alphaproteobacteria,3N9II@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5655237_1	318996.AXAZ01000001_gene4882	7.485e-219	687.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,3JTY7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
TLS2_k127_5655237_23	318996.AXAZ01000001_gene4883	1.61e-77	263.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2UBPX@28211|Alphaproteobacteria,3K2R5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_5655237_4	1038859.AXAU01000001_gene3651	5.978e-183	578.0	COG4663@1|root,COG4663@2|Bacteria,1R40U@1224|Proteobacteria,2U3KB@28211|Alphaproteobacteria,3K34G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_5655237_20	648757.Rvan_2674	1.089e-82	289.0	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2TVMG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the Nudix hydrolase family	nudC	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
TLS2_k127_5655237_28	1168059.KB899087_gene3731	5.488e-62	216.0	COG0720@1|root,COG0720@2|Bacteria,1RI8E@1224|Proteobacteria,2U8NH@28211|Alphaproteobacteria,3EZQN@335928|Xanthobacteraceae	28211|Alphaproteobacteria	H	6-pyruvoyl tetrahydropterin synthase	-	-	-	-	-	-	-	-	-	-	-	-	PTPS
TLS2_k127_5655237_12	460265.Mnod_4662	6.632e-111	368.0	COG0438@1|root,COG0438@2|Bacteria,1P81Z@1224|Proteobacteria,2U314@28211|Alphaproteobacteria,1JWXN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_5655237_22	1123229.AUBC01000003_gene1911	5.165e-79	274.0	COG2518@1|root,COG2518@2|Bacteria,1QVT6@1224|Proteobacteria,2TWMS@28211|Alphaproteobacteria,3K3Z3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_5655237_30	639283.Snov_3737	9.12e-56	201.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2UBYU@28211|Alphaproteobacteria,3F04H@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Prokaryotic cytochrome b561	-	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
TLS2_k127_5655237_24	1211115.ALIQ01000215_gene2365	5.712e-76	266.0	COG1985@1|root,COG1985@2|Bacteria,1RES9@1224|Proteobacteria,2U7YG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	COG1985 Pyrimidine reductase, riboflavin biosynthesis	-	-	1.1.1.193	ko:K00082	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R03458	RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C
TLS2_k127_5655237_7	1197906.CAJQ02000015_gene209	2.145e-162	521.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,3JRHU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_27425	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_5655237_15	717785.HYPMC_0957	4.022e-104	346.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2TQJ9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	ycbL	GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_5655237_33	1348657.M622_15060	6.11e-17	81.0	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2VVS2@28216|Betaproteobacteria,2KX8R@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
TLS2_k127_5655237_13	1116369.KB890024_gene58	7.625e-111	364.0	COG0656@1|root,COG0656@2|Bacteria,1MUH2@1224|Proteobacteria,2TTC2@28211|Alphaproteobacteria,43HEX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Aldo/keto reductase family	yeaE	GO:0003674,GO:0003824,GO:0006081,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016491,GO:0042180,GO:0042182,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0051596,GO:0055114,GO:0071704,GO:1901575	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_5655237_10	1205680.CAKO01000005_gene3548	1.803e-137	454.0	COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2TS1C@28211|Alphaproteobacteria,2JQPK@204441|Rhodospirillales	204441|Rhodospirillales	S	Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
TLS2_k127_5655237_3	717785.HYPMC_4154	8.092e-192	605.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TSW9@28211|Alphaproteobacteria,3N6BS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	ccrM	-	2.1.1.72	ko:K13581	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko02048	-	-	-	N6_N4_Mtase
TLS2_k127_5666447_8	314254.OA2633_08229	3.664e-11	64.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TR3X@28211|Alphaproteobacteria,43WG2@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG0488 ATPase components of ABC transporters with duplicated ATPase domains	uup	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD
TLS2_k127_5666447_3	717785.HYPMC_4617	1.883e-52	190.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2U9UT@28211|Alphaproteobacteria,3N75X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
TLS2_k127_5666447_5	1267005.KB911257_gene1039	5.919e-46	169.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,2U94X@28211|Alphaproteobacteria,3N721@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TLS2_k127_5666447_4	1502851.FG93_01665	1.528e-50	192.0	COG1670@1|root,COG1670@2|Bacteria,1RD77@1224|Proteobacteria,2U851@28211|Alphaproteobacteria,3JVPR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS2_k127_5666447_0	582899.Hden_3313	6.722e-230	722.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2TQSW@28211|Alphaproteobacteria,3N6JD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TLS2_k127_5666447_2	1207063.P24_11195	1.459e-63	227.0	COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,2TV0I@28211|Alphaproteobacteria,2JS4A@204441|Rhodospirillales	204441|Rhodospirillales	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C,GST_C_2,GST_N_3
TLS2_k127_5666447_6	1267005.KB911259_gene3854	2.613e-15	80.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	CP_0328	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS2_k127_5666447_1	517418.Ctha_1145	1.026e-73	265.0	COG4782@1|root,COG4782@2|Bacteria,1FDWU@1090|Chlorobi	1090|Chlorobi	S	Alpha/beta hydrolase of unknown function (DUF900)	-	-	-	-	-	-	-	-	-	-	-	-	DUF900
TLS2_k127_5674426_5	316055.RPE_1063	7.753e-142	459.0	COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2TSDU@28211|Alphaproteobacteria,3JS8M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	drug transmembrane transport	norM	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
TLS2_k127_5674426_2	1123060.JONP01000024_gene2506	8.523e-167	538.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
TLS2_k127_5674426_7	1429916.X566_16075	1.999e-105	349.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,3JWJX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_5674426_11	56110.Oscil6304_0362	1.137e-35	148.0	COG3306@1|root,COG3306@2|Bacteria,1G4SS@1117|Cyanobacteria,1H9Y8@1150|Oscillatoriales	1117|Cyanobacteria	M	glycosyltransferase involved in LPS biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5674426_1	1298867.AUES01000001_gene1805	5.014e-230	715.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2U10C@28211|Alphaproteobacteria,3JR02@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_5674426_9	1122132.AQYH01000003_gene2938	5.621e-62	218.0	COG2020@1|root,COG2020@2|Bacteria,1N2GB@1224|Proteobacteria,2UCT1@28211|Alphaproteobacteria,4BKZK@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TLS2_k127_5674426_6	1304877.KI519399_gene4108	4.443e-110	366.0	COG3826@1|root,COG3826@2|Bacteria,1MWVV@1224|Proteobacteria,2TQMH@28211|Alphaproteobacteria,3JQX5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Oxygenase, catalysing oxidative methylation of damaged DNA	MA20_16285	-	-	ko:K09990	-	-	-	-	ko00000	-	-	-	Oxygenase-NA
TLS2_k127_5674426_3	670307.HYPDE_24188	2.376e-152	496.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2TQRX@28211|Alphaproteobacteria,3N72N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	FL	6-O-methylguanine DNA methyltransferase, DNA binding domain	ada	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18
TLS2_k127_5674426_10	1218074.BAXZ01000023_gene4305	1.508e-54	205.0	COG0412@1|root,COG0412@2|Bacteria,1QZFP@1224|Proteobacteria,2WHKY@28216|Betaproteobacteria,1KHC8@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5674426_4	1547437.LL06_18205	7.502e-149	478.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TU9X@28211|Alphaproteobacteria,43MEU@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	metE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
TLS2_k127_5674426_8	1313172.YM304_00420	3.165e-90	304.0	COG0235@1|root,COG0235@2|Bacteria	2|Bacteria	G	Class ii aldolase	MA20_30505	-	4.1.2.17,5.1.3.4	ko:K01628,ko:K03077	ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120	M00550	R02262,R05850	RC00603,RC00604,RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II,UPF0066
TLS2_k127_5674426_0	1267005.KB911255_gene2547	8.872e-278	861.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3N6G0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
TLS2_k127_5708934_10	1449065.JMLL01000010_gene564	4.404e-33	144.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TQU3@28211|Alphaproteobacteria,43RV4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	PAS fold	pdhS	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9
TLS2_k127_5708934_2	1267005.KB911257_gene909	3.464e-193	618.0	COG3898@1|root,COG3898@2|Bacteria,1P5RR@1224|Proteobacteria,2TT5Q@28211|Alphaproteobacteria,3N6D4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	HemY protein N-terminus	lapB	-	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N,TPR_19
TLS2_k127_5708934_5	1267005.KB911257_gene908	4.382e-99	344.0	COG4223@1|root,COG4223@2|Bacteria,1N3EE@1224|Proteobacteria,2VAHJ@28211|Alphaproteobacteria,3N97M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5708934_9	1267005.KB911257_gene907	8.063e-41	163.0	COG1587@1|root,COG1587@2|Bacteria,1NMTP@1224|Proteobacteria,2U1Y2@28211|Alphaproteobacteria,3N77E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Uroporphyrinogen-III synthase HemD	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
TLS2_k127_5708934_4	670307.HYPDE_41333	2.458e-112	371.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2TS3D@28211|Alphaproteobacteria,3N6I6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
TLS2_k127_5708934_3	1267005.KB911257_gene905	3.216e-139	452.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2TSF7@28211|Alphaproteobacteria,3N66A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360,GO:1901564	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TLS2_k127_5708934_0	1411123.JQNH01000001_gene3185	1.093e-279	877.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2TRCK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0339 Zn-dependent oligopeptidases	dcp	GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
TLS2_k127_5708934_1	288000.BBta_1326	1.217e-245	781.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2TQRS@28211|Alphaproteobacteria,3JRH3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
TLS2_k127_5708934_6	1380394.JADL01000008_gene3609	1.017e-57	211.0	COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,2TZJ8@28211|Alphaproteobacteria,2JUBE@204441|Rhodospirillales	204441|Rhodospirillales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5708934_11	1469245.JFBG01000010_gene596	2.111e-24	108.0	COG0824@1|root,COG0824@2|Bacteria,1PHMB@1224|Proteobacteria,1SE98@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_2
TLS2_k127_5708934_7	1267005.KB911255_gene2704	6.012e-51	201.0	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,2UF9I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG1525 Micrococcal nuclease (thermonuclease) homologs	-	-	-	-	-	-	-	-	-	-	-	-	SNase
TLS2_k127_5708934_8	272630.MexAM1_META1p4335	7.35e-44	167.0	28I53@1|root,2Z88I@2|Bacteria,1NE5N@1224|Proteobacteria,2TTBB@28211|Alphaproteobacteria,1JU1F@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3750)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3750
TLS2_k127_5713389_0	59538.XP_005961804.1	2.015e-209	654.0	COG0114@1|root,KOG1317@2759|Eukaryota,38GHX@33154|Opisthokonta,3BB3C@33208|Metazoa,3CUSS@33213|Bilateria,487GR@7711|Chordata,490UB@7742|Vertebrata,3J6FA@40674|Mammalia	33208|Metazoa	C	Fumarate hydratase	FH	GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
TLS2_k127_5713389_1	717785.HYPMC_4417	2.644e-155	501.0	COG0337@1|root,COG0703@1|root,COG0337@2|Bacteria,COG0703@2|Bacteria,1MUBK@1224|Proteobacteria,2TRDA@28211|Alphaproteobacteria,3N6C8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
TLS2_k127_5713389_2	1267005.KB911257_gene695	1.141e-73	255.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2U76C@28211|Alphaproteobacteria,3N6XN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
TLS2_k127_5713389_3	883078.HMPREF9695_03719	0.0006046	44.0	2EGFM@1|root,33A7M@2|Bacteria,1N8GQ@1224|Proteobacteria,2UG7D@28211|Alphaproteobacteria,3K0XF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	MA20_39815	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_573181_7	1121861.KB899913_gene2139	3.874e-39	148.0	COG0625@1|root,COG0625@2|Bacteria,1RD4X@1224|Proteobacteria,2U750@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the GST superfamily	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_C_3,GST_N,GST_N_3
TLS2_k127_573181_3	1267005.KB911258_gene106	1.63e-102	339.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2TQYN@28211|Alphaproteobacteria,3N6PN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS2_k127_573181_5	582899.Hden_1915	1.893e-77	267.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2U5B2@28211|Alphaproteobacteria,3N6SC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
TLS2_k127_573181_4	717785.HYPMC_2868	8.489e-99	328.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2TTVJ@28211|Alphaproteobacteria,3N6N1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS2_k127_573181_6	1267005.KB911258_gene103	3.098e-64	231.0	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,2U9ED@28211|Alphaproteobacteria,3N75T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Cytidylyltransferase family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TLS2_k127_573181_1	670307.HYPDE_29008	1.82e-142	466.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2TSD1@28211|Alphaproteobacteria,3N82P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
TLS2_k127_573181_2	1120983.KB894570_gene1962	1.176e-133	438.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2TQXJ@28211|Alphaproteobacteria,1JN0R@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Peptidase family M50	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
TLS2_k127_573181_0	1267005.KB911258_gene100	1.329e-235	744.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2TR7W@28211|Alphaproteobacteria,3N6CC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TLS2_k127_573479_4	1054213.HMPREF9946_04745	2.577e-57	206.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2TV2G@28211|Alphaproteobacteria,2JRYP@204441|Rhodospirillales	204441|Rhodospirillales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	DUF3305,NTP_transf_3
TLS2_k127_573479_7	1207063.P24_06047	7.11e-08	58.0	2EIVU@1|root,33CM4@2|Bacteria,1NH4D@1224|Proteobacteria,2UJVJ@28211|Alphaproteobacteria,2JUJ0@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
TLS2_k127_573479_1	1121861.KB899913_gene2257	6.495e-97	323.0	COG0693@1|root,COG0693@2|Bacteria,1N8N6@1224|Proteobacteria,2TT0U@28211|Alphaproteobacteria,2JRW6@204441|Rhodospirillales	204441|Rhodospirillales	S	DJ-1/PfpI family	-	-	4.2.1.103	ko:K18199	ko00930,map00930	-	R05771	RC01467	ko00000,ko00001,ko01000,ko01002	-	-	-	DJ-1_PfpI
TLS2_k127_573479_2	113395.AXAI01000007_gene1460	9.819e-92	308.0	COG1011@1|root,COG1011@2|Bacteria,1NCRU@1224|Proteobacteria,2U167@28211|Alphaproteobacteria,3JXS9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS2_k127_573479_0	1510531.JQJJ01000010_gene1874	2.404e-141	466.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TSQ3@28211|Alphaproteobacteria,3JSXI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Putative serine dehydratase domain	dhaa	-	4.1.3.41	ko:K18425	-	-	-	-	ko00000,ko01000	-	-	-	Ala_racemase_N,D-ser_dehydrat
TLS2_k127_573479_3	670307.HYPDE_23808	5.318e-74	261.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2TTP3@28211|Alphaproteobacteria,3N71F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
TLS2_k127_573479_6	420324.KI912007_gene8844	4.557e-20	100.0	COG0582@1|root,COG0582@2|Bacteria,1MXE7@1224|Proteobacteria,2U1Q0@28211|Alphaproteobacteria,1JSKG@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
TLS2_k127_5734906_9	318996.AXAZ01000030_gene4131	2.964e-159	507.0	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,2U0E0@28211|Alphaproteobacteria,3JS2D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Beta-lactamase	MA20_27655	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_5734906_18	1231190.NA8A_00155	9.549e-105	346.0	28JXP@1|root,2Z9N4@2|Bacteria,1MXG4@1224|Proteobacteria,2TSXI@28211|Alphaproteobacteria,43HHP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	MA20_24470	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
TLS2_k127_5734906_6	1205680.CAKO01000008_gene4082	5.401e-187	597.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria,2JQ5F@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_5734906_17	1121106.JQKB01000062_gene100	6.182e-105	348.0	COG0778@1|root,COG0778@2|Bacteria,1NIJ8@1224|Proteobacteria,2TUQN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Nitroreductase	-	-	-	ko:K10678	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
TLS2_k127_5734906_5	1267005.KB911257_gene1061	2.183e-189	600.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TTMF@28211|Alphaproteobacteria,3N64T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739,ko:K10764	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS2_k127_5734906_7	1267005.KB911257_gene1062	1.837e-164	550.0	COG0717@1|root,COG0717@2|Bacteria,1MVDH@1224|Proteobacteria,2TR5U@28211|Alphaproteobacteria,3N6C9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	2-deoxycytidine 5-triphosphate deaminase	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
TLS2_k127_5734906_30	1231190.NA8A_04400	5.135e-50	188.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TRQ7@28211|Alphaproteobacteria,43H1B@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_5734906_37	663610.JQKO01000005_gene2457	5.312e-32	130.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria,3NBKA@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_5734906_19	648757.Rvan_0086	1.585e-102	348.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2TRA4@28211|Alphaproteobacteria,3N9IT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_5734906_15	582899.Hden_2568	2.854e-127	416.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2TS96@28211|Alphaproteobacteria,3N7TC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	ArgK protein	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS2_k127_5734906_36	670307.HYPDE_36433	1.63e-35	144.0	COG2039@1|root,COG2039@2|Bacteria,1MWYG@1224|Proteobacteria,2TU8G@28211|Alphaproteobacteria,3N949@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Pyroglutamyl peptidase	MA20_15835	-	3.4.19.3	ko:K01304	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C15
TLS2_k127_5734906_2	1205680.CAKO01000002_gene2230	2.606e-214	676.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,2JR2A@204441|Rhodospirillales	204441|Rhodospirillales	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
TLS2_k127_5734906_42	670307.HYPDE_33868	7.423e-05	55.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,3N68D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_5734906_1	391937.NA2_15469	7.123e-224	697.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TT67@28211|Alphaproteobacteria,43IB2@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily	adhC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0008150,GO:0008152,GO:0015945,GO:0034308,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:1901615	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_5734906_26	670307.HYPDE_38093	1.36e-62	239.0	COG5342@1|root,COG5342@2|Bacteria,1NA8M@1224|Proteobacteria,2TSY3@28211|Alphaproteobacteria,3N739@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Invasion associated locus B	MA20_19790	-	-	-	-	-	-	-	-	-	-	-	IalB
TLS2_k127_5734906_16	1380394.JADL01000010_gene4134	3.236e-105	344.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2TRRS@28211|Alphaproteobacteria,2JPTP@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
TLS2_k127_5734906_14	717785.HYPMC_1162	9.468e-131	450.0	COG2885@1|root,COG2885@2|Bacteria,1MWHF@1224|Proteobacteria,2TUGX@28211|Alphaproteobacteria,3N7AT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the ompA family	MA20_22450	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	BON,OmpA
TLS2_k127_5734906_25	1267005.KB911262_gene3312	4.812e-63	236.0	COG3743@1|root,COG3743@2|Bacteria,1N76A@1224|Proteobacteria,2UFVP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	rRNA binding	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	-
TLS2_k127_5734906_24	1185652.USDA257_c28370	1.045e-74	271.0	COG2304@1|root,COG4249@1|root,COG2304@2|Bacteria,COG4249@2|Bacteria,1MXFD@1224|Proteobacteria,2TR94@28211|Alphaproteobacteria,4BM49@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	C-type lectin (CTL) or carbohydrate-recognition domain (CRD)	-	-	-	-	-	-	-	-	-	-	-	-	Lectin_C,Peptidase_C14
TLS2_k127_5734906_21	717785.HYPMC_2963	1.016e-81	282.0	COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,2U0W2@28211|Alphaproteobacteria,3N6WV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the SOS response-associated peptidase family	MA20_42060	-	-	-	-	-	-	-	-	-	-	-	SRAP
TLS2_k127_5734906_11	1207063.P24_00620	7.617e-150	492.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2TTGM@28211|Alphaproteobacteria,2JPI4@204441|Rhodospirillales	204441|Rhodospirillales	E	Peptidase family M20/M25/M40	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_5734906_10	1380394.JADL01000017_gene479	1.786e-155	505.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,2JR2A@204441|Rhodospirillales	204441|Rhodospirillales	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
TLS2_k127_5734906_28	335543.Sfum_3561	2.045e-53	196.0	COG0317@1|root,COG0317@2|Bacteria,1RCK7@1224|Proteobacteria,42SEV@68525|delta/epsilon subdivisions,2WPK4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_4
TLS2_k127_5734906_32	1211115.ALIQ01000018_gene2142	3.023e-45	172.0	COG4665@1|root,COG4665@2|Bacteria,1QY3M@1224|Proteobacteria,2TXS4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3090 TRAP-type C4-dicarboxylate transport system small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_5734906_4	1187851.A33M_0513	6.842e-191	607.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,3FDRY@34008|Rhodovulum	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_5734906_39	518766.Rmar_0212	8.007e-22	100.0	COG2105@1|root,COG2105@2|Bacteria	2|Bacteria	F	PFAM AIG2 family protein	-	-	4.3.1.27	ko:K20757	-	-	-	-	ko00000,ko01000	-	-	-	GGACT
TLS2_k127_5734906_35	1500257.JQNM01000007_gene1660	2.853e-39	169.0	COG0346@1|root,COG0346@2|Bacteria,1RFNK@1224|Proteobacteria,2U807@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
TLS2_k127_5734906_0	582899.Hden_1813	0.0	1778.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,3N6ID@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS2_k127_5734906_23	1267005.KB911258_gene556	3.096e-75	258.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,3N6TK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TLS2_k127_5734906_8	631454.N177_3211	7.663e-161	520.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2TRPX@28211|Alphaproteobacteria,1JN0M@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS2_k127_5734906_29	1472716.KBK24_0119455	4.791e-50	181.0	COG0824@1|root,COG0824@2|Bacteria,1RGZN@1224|Proteobacteria,2VREZ@28216|Betaproteobacteria,1K703@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM thioesterase superfamily protein	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
TLS2_k127_5734906_38	1123072.AUDH01000009_gene462	8.67e-27	113.0	COG0251@1|root,COG0251@2|Bacteria,1MZ5K@1224|Proteobacteria,2U9DU@28211|Alphaproteobacteria,2JTAM@204441|Rhodospirillales	204441|Rhodospirillales	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS2_k127_5734906_33	670307.HYPDE_29433	2.842e-42	159.0	COG0251@1|root,COG0251@2|Bacteria,1MZ5K@1224|Proteobacteria,2U9DU@28211|Alphaproteobacteria,3N7AW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS2_k127_5734906_20	1267005.KB911262_gene3320	1.639e-94	324.0	COG2215@1|root,COG2215@2|Bacteria,1MWIW@1224|Proteobacteria,2TSIM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the NiCoT transporter (TC 2.A.52) family	-	-	-	ko:K08970	-	-	-	-	ko00000,ko02000	2.A.52.2	-	-	NicO
TLS2_k127_5734906_34	1267005.KB911262_gene3319	6.559e-42	167.0	COG3683@1|root,COG3683@2|Bacteria,1R4QA@1224|Proteobacteria,2VGNV@28211|Alphaproteobacteria,3N70H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1007)	MA20_06510	-	-	-	-	-	-	-	-	-	-	-	DUF1007
TLS2_k127_5734906_13	1333998.M2A_0282	1.604e-139	471.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2U4KP@28211|Alphaproteobacteria,4BR8T@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,MASE1,MHYT,PAS,PAS_3,PAS_4,PAS_7,Response_reg
TLS2_k127_5734906_12	1304878.AUGD01000015_gene6839	1.666e-145	471.0	COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2TR7D@28211|Alphaproteobacteria,3JUQ6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
TLS2_k127_5734906_3	1007105.PT7_0667	3.596e-193	612.0	COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2VM1E@28216|Betaproteobacteria,3T8R9@506|Alcaligenaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_5734906_27	582899.Hden_2183	7.315e-55	196.0	COG0727@1|root,COG0727@2|Bacteria,1N5PC@1224|Proteobacteria,2UFEE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
TLS2_k127_5734906_31	1267005.KB911259_gene3862	1.598e-47	178.0	COG3153@1|root,COG3153@2|Bacteria,1RD0C@1224|Proteobacteria,2U7AS@28211|Alphaproteobacteria,3N79B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_9
TLS2_k127_5734906_22	1280946.HY29_00295	4.819e-80	270.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TQJR@28211|Alphaproteobacteria,43XBB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Acetyl-coenzyme A synthetase N-terminus	prpE	GO:0003674,GO:0003824,GO:0003987,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0017144,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046950,GO:0046951,GO:0070013,GO:0071704,GO:1901568,GO:1901570,GO:1901576,GO:1902224	6.2.1.1,6.2.1.17	ko:K01895,ko:K01908	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_5743119_23	2074.JNYD01000013_gene6900	0.0002014	53.0	COG5412@1|root,COG5412@2|Bacteria,2H75F@201174|Actinobacteria,4E94N@85010|Pseudonocardiales	201174|Actinobacteria	S	phage tail tape measure protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5743119_19	670307.HYPDE_37248	6.801e-40	160.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	sinR	-	-	ko:K07782,ko:K15852,ko:K18304,ko:K19731,ko:K19733	ko02020,ko02024,ko02025,ko02026,map02020,map02024,map02025,map02026	M00644,M00769	-	-	ko00000,ko00001,ko00002,ko01504,ko03000	-	-	-	Autoind_bind,GerE
TLS2_k127_5743119_17	883126.HMPREF9710_01744	1.403e-45	170.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2W28J@28216|Betaproteobacteria,478RC@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	[2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Fer2_2
TLS2_k127_5743119_2	1120983.KB894571_gene2084	2.786e-204	663.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,1JPB5@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
TLS2_k127_5743119_11	1449065.JMLL01000011_gene2442	1.524e-110	370.0	COG0665@1|root,COG0665@2|Bacteria,1MVRR@1224|Proteobacteria,2TSET@28211|Alphaproteobacteria,43J6Y@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS2_k127_5743119_20	582899.Hden_2263	4.979e-32	125.0	COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,2UF5Q@28211|Alphaproteobacteria,3N798@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0337 (CsbD) family	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
TLS2_k127_5743119_0	1101190.ARWB01000001_gene2655	6.462e-258	811.0	COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,2TRQ9@28211|Alphaproteobacteria,36XKG@31993|Methylocystaceae	28211|Alphaproteobacteria	L	ATP dependent DNA ligase C terminal region	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
TLS2_k127_5743119_4	1120792.JAFV01000001_gene2439	9.9e-158	503.0	COG1236@1|root,COG1236@2|Bacteria,1MV7U@1224|Proteobacteria,2TQU5@28211|Alphaproteobacteria,36Y52@31993|Methylocystaceae	28211|Alphaproteobacteria	J	exonuclease of the beta-lactamase fold involved in RNA processing	MA20_22065	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Lactamase_B
TLS2_k127_5743119_12	670307.HYPDE_32333	3.545e-110	366.0	COG1793@1|root,COG1793@2|Bacteria,1NTIR@1224|Proteobacteria,2UPWW@28211|Alphaproteobacteria,3N9IH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	ATP dependent DNA ligase C terminal region	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS2_k127_5743119_1	717785.HYPMC_2433	1.02e-239	752.0	COG3285@1|root,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria,3N6F4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA ligase	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS2_k127_5743119_7	1267005.KB911258_gene187	9.681e-129	421.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,2TRTI@28211|Alphaproteobacteria,3N6MX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
TLS2_k127_5743119_18	883078.HMPREF9695_00598	3.106e-42	170.0	2DMG3@1|root,32RAX@2|Bacteria,1QW8A@1224|Proteobacteria,2TWSG@28211|Alphaproteobacteria,3JVP1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5743119_15	1121033.AUCF01000027_gene2733	1.941e-57	214.0	COG4645@1|root,COG4645@2|Bacteria,1PI9Q@1224|Proteobacteria,2U1C7@28211|Alphaproteobacteria,2JSSY@204441|Rhodospirillales	204441|Rhodospirillales	S	OpgC protein	-	-	-	-	-	-	-	-	-	-	-	-	OpgC_C
TLS2_k127_5743119_22	622637.KE124774_gene2573	1.204e-06	59.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,36XJI@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_5743119_16	717785.HYPMC_4173	5.946e-57	209.0	COG4233@1|root,COG4233@2|Bacteria,1REVE@1224|Proteobacteria,2VEXK@28211|Alphaproteobacteria,3N7F9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CO	Disulphide bond corrector protein DsbC	-	-	-	-	-	-	-	-	-	-	-	-	DsbC
TLS2_k127_5743119_13	717785.HYPMC_4174	3.352e-72	248.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2TTX4@28211|Alphaproteobacteria,3N6Z7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	MA20_18155	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
TLS2_k127_5743119_6	670307.HYPDE_36528	1.007e-129	428.0	COG1519@1|root,COG2121@1|root,COG1519@2|Bacteria,COG2121@2|Bacteria,1MU9F@1224|Proteobacteria,2TS37@28211|Alphaproteobacteria,3N83H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Domain of unknown function (DUF374)	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
TLS2_k127_5743119_14	582899.Hden_2586	3.043e-60	217.0	COG2365@1|root,COG2365@2|Bacteria,1REIM@1224|Proteobacteria,2U7HD@28211|Alphaproteobacteria,3N8EQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Protein tyrosine serine phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF442,Y_phosphatase3
TLS2_k127_5743119_10	1380380.JIAX01000006_gene1050	5.995e-117	406.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2TSPY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_9
TLS2_k127_5743119_5	1267005.KB911263_gene1294	5.486e-131	429.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,3N6G2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)	ispDF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
TLS2_k127_5743119_8	1267005.KB911263_gene1293	1.12e-125	411.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2TRC8@28211|Alphaproteobacteria,3N67V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
TLS2_k127_5743119_3	1267005.KB911263_gene1292	2.247e-165	529.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2TQS1@28211|Alphaproteobacteria,3N6I4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phospho-acceptor) domain	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
TLS2_k127_5743119_9	717785.HYPMC_2074	4.049e-121	392.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3N69C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Sigma-54 interaction domain	ntrC	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat
TLS2_k127_5743463_4	717785.HYPMC_2325	1.314e-140	454.0	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,2TSRR@28211|Alphaproteobacteria,3N6A3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	-	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
TLS2_k127_5743463_2	717785.HYPMC_2893	9.562e-239	745.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TRAH@28211|Alphaproteobacteria,3N6GF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
TLS2_k127_5743463_0	648757.Rvan_0817	0.0	1412.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,3N648@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS2_k127_5743463_8	717785.HYPMC_1935	6.313e-20	98.0	COG2938@1|root,COG2938@2|Bacteria,1Q6AE@1224|Proteobacteria,2VCGP@28211|Alphaproteobacteria,3N7CV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Flavinator of succinate dehydrogenase	-	-	-	ko:K09159	-	-	-	-	ko00000,ko02048	-	-	-	Sdh5
TLS2_k127_5743463_1	717785.HYPMC_1934	0.0	1043.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2TR86@28211|Alphaproteobacteria,3N6HP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Helicase	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
TLS2_k127_5743463_3	1267005.KB911257_gene924	3.244e-141	463.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2TSIA@28211|Alphaproteobacteria,3N6F7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	rsmB	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
TLS2_k127_5743463_5	1267005.KB911257_gene925	5.232e-132	428.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2TS3N@28211|Alphaproteobacteria,3N6IW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS2_k127_5743463_9	717785.HYPMC_4806	1.016e-13	75.0	COG5508@1|root,COG5508@2|Bacteria,1N7D3@1224|Proteobacteria,2UF8M@28211|Alphaproteobacteria,3N7D2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1674)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1674
TLS2_k127_5743463_6	1267005.KB911257_gene927	3.263e-90	313.0	COG2304@1|root,COG4961@1|root,COG2304@2|Bacteria,COG4961@2|Bacteria,1MWXU@1224|Proteobacteria,2TRQP@28211|Alphaproteobacteria,3N7FF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad,VWA
TLS2_k127_5743463_7	670307.HYPDE_29738	2.759e-48	178.0	COG5387@1|root,COG5387@2|Bacteria,1Q3B5@1224|Proteobacteria,2TVK1@28211|Alphaproteobacteria,3N6VU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	ATP12 chaperone protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP12
TLS2_k127_5770883_5	1305735.JAFT01000005_gene2326	2.84e-164	525.0	COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,2TTCA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0076 Glutamate decarboxylase and related PLP-dependent proteins	-	-	4.1.2.27	ko:K01634	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00100	R02464,R06516	RC00264,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
TLS2_k127_5770883_6	1187851.A33M_3560	3.559e-122	402.0	COG0524@1|root,COG0524@2|Bacteria,1QN1N@1224|Proteobacteria,2U6VG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS2_k127_5770883_14	648757.Rvan_3333	1.479e-64	231.0	COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2U9NF@28211|Alphaproteobacteria,3N74S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
TLS2_k127_5770883_1	266779.Meso_1528	7.341e-262	819.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2TRMQ@28211|Alphaproteobacteria,43HKE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
TLS2_k127_5770883_2	648757.Rvan_3331	7.257e-190	606.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,2TQMP@28211|Alphaproteobacteria,3N6HC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Glycosyltransferase family 20	otsA	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
TLS2_k127_5770883_19	648885.KB316282_gene496	2.288e-29	130.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2U0CA@28211|Alphaproteobacteria,1JTBF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
TLS2_k127_5770883_18	1123392.AQWL01000003_gene344	5.352e-40	151.0	COG2076@1|root,COG2076@2|Bacteria,1MZ6P@1224|Proteobacteria,2VU3F@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Pfam Small Multidrug Resistance protein	sugE_1	-	-	ko:K11741	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
TLS2_k127_5770883_13	1429916.X566_15885	1.645e-67	235.0	COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,2TVKC@28211|Alphaproteobacteria,3JTB7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	MA20_15865	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_5770883_20	876269.ARWA01000001_gene15	2.408e-22	106.0	COG5662@1|root,COG5662@2|Bacteria,1QPSZ@1224|Proteobacteria,2TU7W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5770883_11	883080.HMPREF9697_01272	8.974e-82	301.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2TT0E@28211|Alphaproteobacteria,3JTSC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS2_k127_5770883_15	216596.pRL80022	4.437e-57	209.0	COG1073@1|root,COG1073@2|Bacteria,1QUD5@1224|Proteobacteria,2TX8A@28211|Alphaproteobacteria,4BNUB@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Acetyl xylan esterase (AXE1)	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4
TLS2_k127_5770883_21	438753.AZC_4277	6.792e-17	84.0	COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,2U5HA@28211|Alphaproteobacteria,3F15P@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	cpdA	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
TLS2_k127_5770883_4	1205680.CAKO01000007_gene4414	1.83e-169	540.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,2JZCB@204441|Rhodospirillales	204441|Rhodospirillales	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
TLS2_k127_5770883_9	392499.Swit_1675	1.045e-101	342.0	COG2141@1|root,COG2141@2|Bacteria,1NKS6@1224|Proteobacteria,2TT87@28211|Alphaproteobacteria,2K2W4@204457|Sphingomonadales	204457|Sphingomonadales	C	Luciferase-like monooxygenase	-	-	1.14.13.107	ko:K14733	ko00903,map00903	-	R06398,R09385,R09389,R09393	RC01506	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
TLS2_k127_5770883_17	1424334.W822_16015	4.87e-40	152.0	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
TLS2_k127_5770883_10	1267005.KB911264_gene3155	1.048e-90	312.0	28HDQ@1|root,2Z7Q9@2|Bacteria,1R41M@1224|Proteobacteria,2TTYR@28211|Alphaproteobacteria,3N7WW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5770883_3	582899.Hden_1297	2.588e-180	575.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2VDGB@28211|Alphaproteobacteria,3N7P3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_5770883_8	582899.Hden_1296	1.812e-109	365.0	28J0S@1|root,2Z8XX@2|Bacteria,1P9IP@1224|Proteobacteria,2TSZQ@28211|Alphaproteobacteria,3N827@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5770883_16	1336243.JAEA01000012_gene2873	6.058e-47	176.0	COG2847@1|root,COG4549@1|root,COG2847@2|Bacteria,COG4549@2|Bacteria,1MZ3M@1224|Proteobacteria,2UBUR@28211|Alphaproteobacteria,1JRF4@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	nuclear export factor GLE1	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	DUF1775,PCuAC
TLS2_k127_5770883_7	1038860.AXAP01000001_gene6296	9.502e-114	379.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TSX9@28211|Alphaproteobacteria,3JRBX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	BQ	Histone deacetylase domain	hdaH	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
TLS2_k127_5770883_12	1380394.JADL01000001_gene2288	1.314e-70	256.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2TV9W@28211|Alphaproteobacteria,2JRRC@204441|Rhodospirillales	204441|Rhodospirillales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TLS2_k127_5770883_0	1380394.JADL01000001_gene2289	3.884e-311	979.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JPPE@204441|Rhodospirillales	204441|Rhodospirillales	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TLS2_k127_5782906_6	1267005.KB911256_gene1653	6.237e-54	204.0	2E6Z4@1|root,331IA@2|Bacteria,1NFY1@1224|Proteobacteria,2UHSC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5782906_4	717785.HYPMC_2958	3.624e-78	269.0	COG1024@1|root,COG1024@2|Bacteria,1Q67Q@1224|Proteobacteria,2U2T5@28211|Alphaproteobacteria,3N8DG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_5782906_0	1267005.KB911255_gene2506	9.02e-307	957.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,2TR3Z@28211|Alphaproteobacteria,3N6EH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Belongs to the PEP-utilizing enzyme family	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
TLS2_k127_5782906_1	670307.HYPDE_41713	5.031e-205	646.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2TRFA@28211|Alphaproteobacteria,3N65I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the aspartokinase family	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
TLS2_k127_5782906_2	631454.N177_0279	4.65e-117	388.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,1JMYG@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
TLS2_k127_5782906_3	1267005.KB911256_gene1888	1.763e-115	381.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2TRP4@28211|Alphaproteobacteria,3N6TN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
TLS2_k127_5782906_7	1267005.KB911256_gene1887	3.464e-12	70.0	COG3242@1|root,COG3242@2|Bacteria,1NGPZ@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	MA20_02305	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
TLS2_k127_5782906_5	648757.Rvan_3517	1.695e-65	242.0	COG3203@1|root,COG3203@2|Bacteria,1N25J@1224|Proteobacteria,2TYC2@28211|Alphaproteobacteria,3N9J4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
TLS2_k127_5786840_2	936455.KI421499_gene94	1.776e-37	156.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria,3JQW2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TLS2_k127_5786840_1	1038859.AXAU01000013_gene6540	1.433e-81	279.0	COG0600@1|root,COG0600@2|Bacteria,1R5K5@1224|Proteobacteria,2TSBZ@28211|Alphaproteobacteria,3JSSG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TLS2_k127_5786840_0	172088.AUGA01000037_gene3728	3.28e-95	323.0	COG0715@1|root,COG0715@2|Bacteria,1NAXC@1224|Proteobacteria,2U2C2@28211|Alphaproteobacteria,3JW3B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TLS2_k127_5786840_3	1168059.KB899087_gene527	2.246e-10	68.0	2CPI3@1|root,32SJ7@2|Bacteria,1N1IR@1224|Proteobacteria,2UBVS@28211|Alphaproteobacteria,3EZWS@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF992
TLS2_k127_5796337_2	1205680.CAKO01000008_gene4205	1.934e-169	552.0	COG0028@1|root,COG0028@2|Bacteria,1MWVW@1224|Proteobacteria,2TTH5@28211|Alphaproteobacteria,2JW3I@204441|Rhodospirillales	204441|Rhodospirillales	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_5796337_7	1267005.KB911263_gene1276	3.689e-93	322.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2TSJ3@28211|Alphaproteobacteria,3N7BI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	SurA N-terminal domain	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N,SurA_N_3
TLS2_k127_5796337_5	1267005.KB911263_gene1275	1.32e-113	381.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria,3N6H1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
TLS2_k127_5796337_3	1267005.KB911263_gene1274	1.558e-117	385.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2TRD9@28211|Alphaproteobacteria,3N63G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TLS2_k127_5796337_4	717785.HYPMC_4111	3.929e-114	375.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2TR01@28211|Alphaproteobacteria,3N6TF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	DnaJ C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,DnaJ_C
TLS2_k127_5796337_1	1267005.KB911255_gene2995	3.93e-207	670.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TR1W@28211|Alphaproteobacteria,3N6IU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
TLS2_k127_5796337_0	1267005.KB911255_gene2994	0.0	1074.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2TRBP@28211|Alphaproteobacteria,3N6DR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
TLS2_k127_5796337_9	1267005.KB911255_gene2993	1.334e-56	220.0	COG0593@1|root,COG0593@2|Bacteria,1N4PG@1224|Proteobacteria,2U96K@28211|Alphaproteobacteria,3N74G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the DnaA family	hda	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA
TLS2_k127_5796337_6	1267005.KB911255_gene2992	6.555e-102	349.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2TRD3@28211|Alphaproteobacteria,3N6QI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	AI-2E family transporter	perM	-	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
TLS2_k127_5796337_8	1267005.KB911255_gene2991	1.355e-67	235.0	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,2U7AP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	MA20_28295	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_5796337_11	402626.Rpic_0030	8.17e-08	54.0	COG0625@1|root,COG0625@2|Bacteria,1NUET@1224|Proteobacteria,2VKA7@28216|Betaproteobacteria,1K4M5@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Glutathione S-transferase	gstN	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
TLS2_k127_581460_0	1267005.KB911265_gene3597	3.268e-295	934.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,3N6H7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	PD-(D/E)XK nuclease superfamily	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
TLS2_k127_581460_8	582899.Hden_2308	2.506e-85	302.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2TU2V@28211|Alphaproteobacteria,3N734@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	JM	Nucleotidyl transferase	MA20_24100	-	2.7.7.13,2.7.7.99	ko:K00966,ko:K00992	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885,R11025	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_3,NTP_transferase
TLS2_k127_581460_7	582899.Hden_0419	6.724e-89	316.0	COG1479@1|root,COG1479@2|Bacteria,1NRBC@1224|Proteobacteria,2U5VC@28211|Alphaproteobacteria,3N972@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function DUF262	-	-	-	-	-	-	-	-	-	-	-	-	DUF1524,DUF262
TLS2_k127_581460_11	1123229.AUBC01000027_gene4024	6.426e-67	242.0	COG0491@1|root,COG0491@2|Bacteria,1MY6G@1224|Proteobacteria,2TSXC@28211|Alphaproteobacteria,3K61X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_581460_3	717785.HYPMC_2053	3.523e-128	423.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2TR89@28211|Alphaproteobacteria,3N64S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
TLS2_k127_581460_1	1267005.KB911258_gene601	6.116e-215	673.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TR32@28211|Alphaproteobacteria,3N6JQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS2_k127_581460_14	1267005.KB911258_gene600	5.274e-34	132.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,2UBWW@28211|Alphaproteobacteria,3N7AA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS2_k127_581460_6	1267005.KB911258_gene599	9.719e-113	370.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2TQZG@28211|Alphaproteobacteria,3N68Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	PFAM short-chain dehydrogenase reductase SDR	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_581460_2	582899.Hden_1712	5.701e-144	464.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2TRTT@28211|Alphaproteobacteria,3N64Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	malonyl CoA-acyl carrier protein transacylase	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
TLS2_k127_581460_9	331869.BAL199_04279	5.211e-84	287.0	COG1028@1|root,COG1028@2|Bacteria,1QU4S@1224|Proteobacteria,2TRYW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_581460_10	1122970.AUHC01000004_gene2340	3.337e-75	262.0	COG0637@1|root,COG0637@2|Bacteria,1NSPA@1224|Proteobacteria,2U0W3@28211|Alphaproteobacteria,2K05N@204457|Sphingomonadales	204457|Sphingomonadales	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS2_k127_581460_5	1121106.JQKB01000013_gene5483	2.929e-123	410.0	COG0491@1|root,COG0491@2|Bacteria,1N22F@1224|Proteobacteria,2U2V5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_581460_13	1869.MB27_24360	1.698e-48	179.0	COG3832@1|root,COG3832@2|Bacteria,2IMFE@201174|Actinobacteria	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_581460_12	1120950.KB892796_gene2257	1.322e-49	179.0	COG0640@1|root,COG0640@2|Bacteria,2GNW2@201174|Actinobacteria,4DSFS@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,HTH_20
TLS2_k127_581460_4	1411123.JQNH01000001_gene3179	4.762e-125	408.0	COG1250@1|root,COG1250@2|Bacteria,1MV8M@1224|Proteobacteria,2TRAW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N
TLS2_k127_5824390_4	1396141.BATP01000056_gene3226	5.909e-23	100.0	COG1216@1|root,COG1216@2|Bacteria,46TK6@74201|Verrucomicrobia,2IUYU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_5824390_2	1229172.JQFA01000004_gene1737	1.726e-92	314.0	COG0438@1|root,COG0438@2|Bacteria,1G0Z5@1117|Cyanobacteria,1H7YK@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_5824390_1	595536.ADVE02000001_gene842	1.085e-100	342.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_5824390_0	595536.ADVE02000001_gene841	7.75e-148	480.0	COG0438@1|root,COG0438@2|Bacteria,1Q0M0@1224|Proteobacteria,2UEYP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5824390_3	595536.ADVE02000001_gene840	2.692e-40	162.0	COG0438@1|root,COG0438@2|Bacteria,1RF49@1224|Proteobacteria,2U7J6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_5848984_6	717785.HYPMC_2040	2.768e-50	180.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,3N6J2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
TLS2_k127_5848984_4	991905.SL003B_2411	1.535e-109	368.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2TQKD@28211|Alphaproteobacteria,4BPYA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TLS2_k127_5848984_5	1267005.KB911258_gene588	5.562e-65	226.0	COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,2TUVR@28211|Alphaproteobacteria,3N7BD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Colicin V production protein	cvpA	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
TLS2_k127_5848984_1	1267005.KB911257_gene1036	3.625e-140	458.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria,3N7PD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	yliI	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363	1.1.5.2	ko:K00117,ko:K21430	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	GSDH
TLS2_k127_5848984_10	420324.KI912031_gene2913	3.483e-12	73.0	COG3108@1|root,COG3108@2|Bacteria,1NEAY@1224|Proteobacteria,2UHRJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidase M15	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_3
TLS2_k127_5848984_2	1304878.AUGD01000006_gene6595	5.587e-136	443.0	COG2358@1|root,COG2358@2|Bacteria,1R3ZR@1224|Proteobacteria,2TSND@28211|Alphaproteobacteria,3JV59@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
TLS2_k127_5848984_0	1230476.C207_02394	4.363e-177	563.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TR6X@28211|Alphaproteobacteria,3JU3Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Cytochrome P450	MA20_16575	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_5848984_8	1120956.JHZK01000009_gene1645	6.937e-44	172.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TRQ7@28211|Alphaproteobacteria,1JQ6H@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_5848984_7	1297569.MESS2_1590027	1.149e-46	180.0	COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,2TUMH@28211|Alphaproteobacteria,43GYJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	PFAM KDPG and KHG aldolase	eda	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
TLS2_k127_5848984_3	1265502.KB905970_gene1300	3.009e-120	397.0	COG0524@1|root,COG0524@2|Bacteria,1MVG2@1224|Proteobacteria,2VKA3@28216|Betaproteobacteria,4ACV6@80864|Comamonadaceae	28216|Betaproteobacteria	G	pfkB family carbohydrate kinase	kdgK	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
TLS2_k127_5848984_9	1205680.CAKO01000038_gene1552	4.433e-24	103.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria,2JQXG@204441|Rhodospirillales	204441|Rhodospirillales	S	N-terminal domain of oxidoreductase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
TLS2_k127_5877127_1	1038859.AXAU01000012_gene4374	1.778e-160	518.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JTV0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,EAL,GGDEF,HAMP,PAS_4,PAS_7,PAS_8
TLS2_k127_5877127_7	164757.Mjls_4433	4.307e-54	209.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_5877127_5	582899.Hden_1680	4.556e-62	218.0	COG1846@1|root,COG1846@2|Bacteria,1PJHM@1224|Proteobacteria,2VAEP@28211|Alphaproteobacteria,3N7DM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_5877127_8	1038859.AXAU01000007_gene5832	6.779e-29	122.0	COG0251@1|root,COG0251@2|Bacteria,1RDJX@1224|Proteobacteria,2UMCV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS2_k127_5877127_0	1089552.KI911559_gene2193	9.217e-196	626.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRII@28211|Alphaproteobacteria,2JQB3@204441|Rhodospirillales	204441|Rhodospirillales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_5877127_3	1366050.N234_33760	7.07e-145	472.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2VNJN@28216|Betaproteobacteria,1KGM7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
TLS2_k127_5877127_4	1121106.JQKB01000007_gene1058	2.353e-80	276.0	COG1028@1|root,COG1028@2|Bacteria,1MUPX@1224|Proteobacteria,2TT6C@28211|Alphaproteobacteria,2JS3E@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_5877127_2	1417296.U879_08050	1.057e-158	508.0	COG1856@1|root,COG1856@2|Bacteria,1R6PW@1224|Proteobacteria,2U1YU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Radical SAM	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
TLS2_k127_5877127_6	371731.Rsw2DRAFT_1856	6.131e-59	209.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TRGU@28211|Alphaproteobacteria,1FCJZ@1060|Rhodobacter	28211|Alphaproteobacteria	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TLS2_k127_5882219_15	196490.AUEZ01000036_gene6108	1.431e-41	169.0	2CAJ4@1|root,2ZART@2|Bacteria,1MW6Q@1224|Proteobacteria,2U1UA@28211|Alphaproteobacteria,3JRMF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	in Rhizobium, interactions between MotB and MotC at the periplasmic surface of the motor control the energy flux or the energy coupling that drives flagellar rotation	motC	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K10564	-	-	-	-	ko00000,ko02035	-	-	-	-
TLS2_k127_5882219_13	936455.KI421499_gene151	1.092e-51	203.0	COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,2TTW2@28211|Alphaproteobacteria,3JSIA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	N	Membrane MotB of proton-channel complex MotA/MotB	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
TLS2_k127_5882219_3	1121028.ARQE01000005_gene2933	3.259e-126	423.0	COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,2TR6J@28211|Alphaproteobacteria,2PKER@255475|Aurantimonadaceae	28211|Alphaproteobacteria	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
TLS2_k127_5882219_9	670307.HYPDE_38648	8.298e-88	301.0	COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2TUQQ@28211|Alphaproteobacteria,3N7GJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	flaA	GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
TLS2_k127_5882219_6	1267005.KB911255_gene2745	3.006e-96	323.0	COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,2TT93@28211|Alphaproteobacteria,3N6MV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	Plays a role in the flagellum-specific transport system	fliP	GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
TLS2_k127_5882219_24	864069.MicloDRAFT_00056520	7.706e-13	76.0	COG1580@1|root,COG1580@2|Bacteria,1N9MQ@1224|Proteobacteria,2UH7B@28211|Alphaproteobacteria,1JVKK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
TLS2_k127_5882219_12	1211115.ALIQ01000185_gene3184	1.103e-60	223.0	COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,2TRHN@28211|Alphaproteobacteria,3N9PT@45404|Beijerinckiaceae	28211|Alphaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
TLS2_k127_5882219_19	670307.HYPDE_38668	5.722e-23	106.0	COG3334@1|root,COG3334@2|Bacteria,1N2RI@1224|Proteobacteria,2TSHS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM MgtE intracellular	-	-	-	-	-	-	-	-	-	-	-	-	MgtE_N
TLS2_k127_5882219_2	1121028.ARQE01000005_gene2939	3.043e-129	428.0	COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,2TQNX@28211|Alphaproteobacteria,2PKGD@255475|Aurantimonadaceae	28211|Alphaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
TLS2_k127_5882219_17	443598.AUFA01000006_gene3554	1.083e-25	113.0	COG1261@1|root,COG1261@2|Bacteria,1MZIR@1224|Proteobacteria,2UDQ2@28211|Alphaproteobacteria,3JYC1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	NO	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly	flgA	-	-	ko:K02386	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	ChapFlgA
TLS2_k127_5882219_5	1122963.AUHB01000003_gene4112	9.876e-105	347.0	COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,2TRR4@28211|Alphaproteobacteria,36XV2@31993|Methylocystaceae	28211|Alphaproteobacteria	N	Flagella basal body rod protein	flgG	GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TLS2_k127_5882219_23	1120956.JHZK01000001_gene3251	9.336e-18	88.0	COG1677@1|root,COG1677@2|Bacteria	2|Bacteria	N	Flagellar hook-basal body complex protein FliE	fliE	GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
TLS2_k127_5882219_14	266779.Meso_0297	2.102e-46	170.0	COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,2U94I@28211|Alphaproteobacteria,43K26@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	N	Belongs to the flagella basal body rod proteins family	flgC	GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TLS2_k127_5882219_16	1267005.KB911255_gene2736	4.534e-27	117.0	COG1815@1|root,COG1815@2|Bacteria,1N33M@1224|Proteobacteria,2VAN3@28211|Alphaproteobacteria,3N927@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	Flagella basal body rod protein	-	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
TLS2_k127_5882219_22	224914.BMEII1115	4.59e-18	91.0	2DKFP@1|root,32UF1@2|Bacteria,1N2B8@1224|Proteobacteria,2UBSX@28211|Alphaproteobacteria,1J2YK@118882|Brucellaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5882219_7	426117.M446_3217	2.259e-94	321.0	COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,2TS13@28211|Alphaproteobacteria,1JRB1@119045|Methylobacteriaceae	28211|Alphaproteobacteria	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
TLS2_k127_5882219_21	1336243.JAEA01000009_gene214	2.384e-20	98.0	COG1886@1|root,COG1886@2|Bacteria,1RGWT@1224|Proteobacteria,2UC6U@28211|Alphaproteobacteria,1JVCH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliN	GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
TLS2_k127_5882219_4	717785.HYPMC_4351	1.996e-123	402.0	COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,2TR5A@28211|Alphaproteobacteria,3N6P1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	MotA/TolQ/ExbB proton channel family	motA	GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
TLS2_k127_5882219_10	991905.SL003B_3852	4.841e-82	284.0	28NHY@1|root,2ZBJH@2|Bacteria,1RAWQ@1224|Proteobacteria,2TYJH@28211|Alphaproteobacteria,4BS3K@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	N	Protein of unknown function (DUF1217)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1217
TLS2_k127_5882219_11	1267005.KB911255_gene2728	5.02e-74	256.0	COG4786@1|root,COG4786@2|Bacteria,1PZ24@1224|Proteobacteria,2U06G@28211|Alphaproteobacteria,3N74A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	Belongs to the flagella basal body rod proteins family	flgF	-	-	ko:K02391,ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TLS2_k127_5882219_1	1120956.JHZK01000001_gene3263	1.283e-151	493.0	COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,2TRXU@28211|Alphaproteobacteria,1JNGF@119043|Rhodobiaceae	28211|Alphaproteobacteria	N	ATP synthase alpha/beta family, nucleotide-binding domain	fliI	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0009288,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0042995,GO:0043226,GO:0043228,GO:0044464	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab
TLS2_k127_5882219_20	371042.NG99_12840	2.56e-21	103.0	COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,1RYZ9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator GntR family	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS2_k127_5882219_8	398525.KB900701_gene1277	1.19e-91	319.0	COG1566@1|root,COG1566@2|Bacteria,1RJ6W@1224|Proteobacteria,2U0PR@28211|Alphaproteobacteria,3JUZ2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
TLS2_k127_5882219_0	670307.HYPDE_24978	3.32e-228	723.0	COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,2TS1X@28211|Alphaproteobacteria,3N6V9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Cellulose synthase	-	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Cellulose_synt,Glyco_tranf_2_3,Glycos_transf_2,PilZ
TLS2_k127_5882219_18	398525.KB900701_gene2641	2.111e-24	108.0	COG2755@1|root,COG2755@2|Bacteria,1MWT8@1224|Proteobacteria,2TTXF@28211|Alphaproteobacteria,3JRB1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_5896373_1	717785.HYPMC_1062	2.793e-125	407.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2TS0S@28211|Alphaproteobacteria,3N7Z1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
TLS2_k127_5896373_2	1197906.CAJQ02000023_gene2466	4.169e-34	136.0	2ENBK@1|root,33FZ7@2|Bacteria,1N3KU@1224|Proteobacteria,2UE58@28211|Alphaproteobacteria,3K5UU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5896373_0	1267005.KB911256_gene1467	0.0	1035.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,3N7YM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	mutB	-	5.4.99.63	ko:K14447	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09292	RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
TLS2_k127_5896373_3	1122132.AQYH01000019_gene243	1.964e-17	82.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,4B7V6@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	cckA	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
TLS2_k127_5898503_0	1207063.P24_15586	6.779e-290	905.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TSAP@28211|Alphaproteobacteria,2JRAB@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.2.3	ko:K07812,ko:K08351	ko00780,ko01100,map00780,map01100	-	R10127	RC03056	ko00000,ko00001,ko01000,ko02000	5.A.3.4	-	-	Molybdopterin,Molydop_binding,TAT_signal
TLS2_k127_5898503_1	107636.JQNK01000009_gene2792	2.385e-283	888.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2TTUM@28211|Alphaproteobacteria,371GC@31993|Methylocystaceae	28211|Alphaproteobacteria	CO	Disulphide bond corrector protein DsbC	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
TLS2_k127_5898503_5	883126.HMPREF9710_03919	1.958e-73	259.0	COG1225@1|root,COG1225@2|Bacteria,1RD2X@1224|Proteobacteria,2VQ4B@28216|Betaproteobacteria	28216|Betaproteobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_5898503_6	1121904.ARBP01000016_gene5249	8.905e-58	215.0	COG0715@1|root,COG0715@2|Bacteria,4NH2X@976|Bacteroidetes,47JPM@768503|Cytophagia	976|Bacteroidetes	P	Protein of unknown function (DUF3500)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3500
TLS2_k127_5898503_8	509635.N824_21255	2.172e-38	157.0	COG0207@1|root,COG0207@2|Bacteria	2|Bacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	-	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
TLS2_k127_5898503_7	338963.Pcar_2009	3.79e-50	188.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WMXB@28221|Deltaproteobacteria,43TTD@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_5898503_3	1267005.KB911258_gene461	6.777e-189	600.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2TRPR@28211|Alphaproteobacteria,3N6D6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TLS2_k127_5898503_2	1267005.KB911256_gene2038	7.906e-273	851.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,3N6ES@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	ABC transporter	abcT3	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_5898503_4	991905.SL003B_1165	3.993e-141	452.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2TQNC@28211|Alphaproteobacteria,4BPF5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
TLS2_k127_5927963_2	1041138.KB890244_gene4894	8.206e-21	101.0	COG0662@1|root,COG0662@2|Bacteria,1NV7E@1224|Proteobacteria,2URV3@28211|Alphaproteobacteria,4BDZQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_5927963_1	1205680.CAKO01000002_gene2194	1.824e-134	434.0	COG1351@1|root,COG1351@2|Bacteria,1MWY8@1224|Proteobacteria,2TTER@28211|Alphaproteobacteria,2JQGP@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
TLS2_k127_5927963_0	331869.BAL199_02349	3.272e-162	526.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2U0XZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_5927963_4	331869.BAL199_02349	1.694e-09	61.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2U0XZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_5930385_6	335659.S23_47700	6.277e-46	172.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,3JRA4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Amidase	MA20_14695	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_5930385_3	1415755.JQLV01000001_gene2594	1.582e-105	358.0	COG2358@1|root,COG2358@2|Bacteria,1R3ZR@1224|Proteobacteria,1RVRS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
TLS2_k127_5930385_1	1380387.JADM01000002_gene2011	7.909e-221	703.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_5930385_4	1411123.JQNH01000001_gene2807	2.45e-70	247.0	COG0589@1|root,COG0589@2|Bacteria,1RATR@1224|Proteobacteria,2U6UI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	PFAM UspA domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_5930385_0	670307.HYPDE_24643	4.873e-256	799.0	COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria,3N6KS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
TLS2_k127_5930385_2	339670.Bamb_5971	2.107e-193	618.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,1K0Z0@119060|Burkholderiaceae	28216|Betaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_5930385_5	1131814.JAFO01000001_gene3189	2.262e-57	201.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TR6E@28211|Alphaproteobacteria,3EY73@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TLS2_k127_5932204_11	1197906.CAJQ02000023_gene2487	3.262e-58	207.0	COG1546@1|root,COG1546@2|Bacteria,1RHXH@1224|Proteobacteria,2UACN@28211|Alphaproteobacteria,3JQZR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the CinA family	MA20_19320	-	-	-	-	-	-	-	-	-	-	-	CinA
TLS2_k127_5932204_1	1502851.FG93_05643	8.155e-134	437.0	COG2807@1|root,COG2807@2|Bacteria,1QV77@1224|Proteobacteria,2TT90@28211|Alphaproteobacteria,3K2XM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_5932204_8	1267005.KB911255_gene2865	1.345e-91	308.0	COG0791@1|root,COG0791@2|Bacteria,1RBV6@1224|Proteobacteria,2TVPH@28211|Alphaproteobacteria,3N8JZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
TLS2_k127_5932204_0	1267005.KB911255_gene2866	6.042e-144	468.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TT2C@28211|Alphaproteobacteria,3N64E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
TLS2_k127_5932204_6	1267005.KB911255_gene2867	1.532e-98	327.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2TSBW@28211|Alphaproteobacteria,3N6P0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
TLS2_k127_5932204_2	686340.Metal_1682	1.714e-132	437.0	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RXW3@1236|Gammaproteobacteria,1XGS8@135618|Methylococcales	135618|Methylococcales	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS2_k127_5932204_4	224911.27353089	4.618e-119	396.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2TQRI@28211|Alphaproteobacteria,3JRTS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	MoeA C-terminal region (domain IV)	moeA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0042802,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS2_k127_5932204_9	717785.HYPMC_1586	4.135e-69	242.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria,3N6ZS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
TLS2_k127_5932204_5	1038858.AXBA01000001_gene3230	1.095e-116	383.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2TSZE@28211|Alphaproteobacteria,3EY7D@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	indole-3-glycerol-phosphate synthase activity	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
TLS2_k127_5932204_7	1267005.KB911259_gene3860	1.727e-92	317.0	COG1409@1|root,COG1409@2|Bacteria,1MXD6@1224|Proteobacteria,2TSJ4@28211|Alphaproteobacteria,3N704@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS2_k127_5932204_12	717785.HYPMC_4404	1.046e-45	175.0	COG1525@1|root,COG1525@2|Bacteria,1R3VA@1224|Proteobacteria,2U0NK@28211|Alphaproteobacteria,3N73J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Staphylococcal nuclease homologue	-	-	-	-	-	-	-	-	-	-	-	-	SNase
TLS2_k127_5932204_3	582899.Hden_2391	4.989e-127	415.0	COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,2TQQD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	PFAM Mg2 transporter protein CorA family protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
TLS2_k127_5938010_2	1205680.CAKO01000040_gene861	1.258e-95	317.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,2JPX1@204441|Rhodospirillales	204441|Rhodospirillales	U	Ammonium transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TLS2_k127_5938010_3	1038858.AXBA01000039_gene5089	2.505e-55	201.0	COG3786@1|root,COG3786@2|Bacteria,1RH22@1224|Proteobacteria,2U992@28211|Alphaproteobacteria,3EZND@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS2_k127_5938010_1	717785.HYPMC_4611	1.414e-119	387.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,2TR97@28211|Alphaproteobacteria,3N6G6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	mtrA	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_5938010_5	911045.PSE_0177	1.819e-19	89.0	COG0333@1|root,COG0333@2|Bacteria,1PU3Y@1224|Proteobacteria,2UF54@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
TLS2_k127_5938010_4	1267005.KB911255_gene2445	3.043e-42	162.0	2E6XE@1|root,331GU@2|Bacteria,1N7WP@1224|Proteobacteria,2UG23@28211|Alphaproteobacteria,3N93P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5938010_0	717785.HYPMC_4082	4.524e-194	623.0	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1RGCV@1224|Proteobacteria,2TWS0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Diguanylate cyclase	MA20_23160	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
TLS2_k127_5948404_9	113395.AXAI01000002_gene5204	3.315e-30	120.0	COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2TQZC@28211|Alphaproteobacteria,3JV9Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_5948404_2	1038859.AXAU01000015_gene928	2.194e-208	651.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TT26@28211|Alphaproteobacteria,3JRSE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_5948404_4	398525.KB900701_gene4391	6.631e-164	522.0	COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,2TTF5@28211|Alphaproteobacteria,3JT53@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH3	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_5948404_5	1411123.JQNH01000001_gene673	4.624e-136	441.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	branched-chain amino acid	cysA	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_5948404_0	384765.SIAM614_24117	5.751e-294	915.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)	fadD3	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS2_k127_5948404_7	1242864.D187_001456	3.05e-72	250.0	COG5649@1|root,COG5649@2|Bacteria,1RDDG@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS2_k127_5948404_6	1267005.KB911255_gene2710	1.632e-74	259.0	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2U6K4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG0631 Serine threonine protein phosphatase	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
TLS2_k127_5948404_8	582899.Hden_3141	1.117e-64	229.0	COG1716@1|root,COG1716@2|Bacteria,1RHU9@1224|Proteobacteria,2UBJ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG1716 FOG FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
TLS2_k127_5948404_10	1267005.KB911255_gene2708	7.388e-16	87.0	COG1716@1|root,COG1716@2|Bacteria,1RAA4@1224|Proteobacteria,2UM3N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA
TLS2_k127_5948404_1	670292.JH26_06340	3.938e-222	700.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,1JTM5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.44,6.2.1.48	ko:K00666,ko:K02182,ko:K20034	ko00920,map00920	-	R10820	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_5948404_3	1294143.H681_00470	1.788e-206	664.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
TLS2_k127_6013654_15	1207063.P24_07684	1.753e-10	64.0	COG2271@1|root,COG2271@2|Bacteria,1R8Q1@1224|Proteobacteria,2U16E@28211|Alphaproteobacteria,2JRZF@204441|Rhodospirillales	204441|Rhodospirillales	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_6013654_2	391937.NA2_02374	2.265e-275	861.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2TRND@28211|Alphaproteobacteria,43IUF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	acsA1	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_6013654_16	1500301.JQMF01000001_gene124	8.961e-08	65.0	COG2982@1|root,COG2982@2|Bacteria,1R4WW@1224|Proteobacteria,2U2RB@28211|Alphaproteobacteria,4B8MJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	AsmA-like C-terminal region	asmA	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
TLS2_k127_6013654_11	402881.Plav_3003	1.967e-56	205.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2U704@28211|Alphaproteobacteria,1JP3Y@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Ribosomal RNA adenine dimethylase	pcm2	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
TLS2_k127_6013654_6	1205680.CAKO01000002_gene3098	5.416e-145	464.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,2JPSA@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_6013654_5	1205680.CAKO01000002_gene3097	3.63e-183	580.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TT26@28211|Alphaproteobacteria,2JPYZ@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_6013654_8	1205680.CAKO01000002_gene3096	1.061e-135	444.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,2JR23@204441|Rhodospirillales	204441|Rhodospirillales	E	branched-chain amino acid transport	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
TLS2_k127_6013654_9	1205680.CAKO01000002_gene3095	2.058e-128	426.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,2JQ6B@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0410 ABC-type branched-chain amino acid transport systems, ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_6013654_1	1038859.AXAU01000006_gene5592	1.006e-296	920.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria,3JSSQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	AMP-binding enzyme	MA20_19425	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS2_k127_6013654_3	1205680.CAKO01000002_gene3092	5.381e-206	646.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2UQXU@28211|Alphaproteobacteria,2JYN9@204441|Rhodospirillales	204441|Rhodospirillales	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
TLS2_k127_6013654_4	1245469.S58_05930	8.715e-205	642.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR15@28211|Alphaproteobacteria,3JQQB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	MA20_22975	-	-	ko:K11731	ko00281,map00281	-	R08089	RC01893	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_6013654_7	1267005.KB911259_gene3689	8.207e-139	457.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,3N63V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470,ko:K21572	-	-	-	-	ko00000,ko01002,ko01011,ko02000	8.A.46.1,8.A.46.3	-	-	PG_binding_1,YkuD
TLS2_k127_6013654_13	1411123.JQNH01000001_gene2045	2.857e-44	172.0	COG2755@1|root,COG2755@2|Bacteria,1MWPZ@1224|Proteobacteria,2TSYR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	PFAM lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS2_k127_6013654_12	1267005.KB911263_gene1374	1.033e-44	169.0	2FGBJ@1|root,330BA@2|Bacteria,1N8XT@1224|Proteobacteria,2UGVU@28211|Alphaproteobacteria,3N8UX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6013654_0	1207063.P24_06941	5.901e-303	944.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2TS9R@28211|Alphaproteobacteria,2JPK5@204441|Rhodospirillales	204441|Rhodospirillales	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
TLS2_k127_6013654_10	762376.AXYL_06111	5.323e-74	255.0	COG3576@1|root,COG3576@2|Bacteria,1MWG9@1224|Proteobacteria,2VQ6P@28216|Betaproteobacteria,3T5FN@506|Alcaligenaceae	28216|Betaproteobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
TLS2_k127_6032608_13	717785.HYPMC_4082	3.876e-08	55.0	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1RGCV@1224|Proteobacteria,2TWS0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Diguanylate cyclase	MA20_23160	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
TLS2_k127_6032608_11	670307.HYPDE_23978	9.524e-35	138.0	2BHF5@1|root,32BH7@2|Bacteria,1N99X@1224|Proteobacteria,2UFY6@28211|Alphaproteobacteria,3N94B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2853)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2853
TLS2_k127_6032608_3	1205680.CAKO01000002_gene2754	8.491e-108	357.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2TTP8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
TLS2_k127_6032608_12	1267005.KB911257_gene1050	2.174e-33	136.0	COG0664@1|root,COG0664@2|Bacteria,1PKW5@1224|Proteobacteria,2UZHZ@28211|Alphaproteobacteria,3N9BJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator, Crp Fnr family	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
TLS2_k127_6032608_6	1267005.KB911259_gene3841	1.803e-68	244.0	COG2834@1|root,COG2834@2|Bacteria,1RA1S@1224|Proteobacteria,2U58W@28211|Alphaproteobacteria,3N7CY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	-	-	-	-	-	-	-	-	-	LolA
TLS2_k127_6032608_9	1267005.KB911257_gene1002	1.096e-52	195.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2UBTB@28211|Alphaproteobacteria,3N74W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
TLS2_k127_6032608_5	1267005.KB911257_gene1003	1.019e-83	285.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2TTFF@28211|Alphaproteobacteria,3N6P9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
TLS2_k127_6032608_8	1437448.AZRT01000037_gene3253	3.235e-58	208.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2U765@28211|Alphaproteobacteria,1J1U7@118882|Brucellaceae	28211|Alphaproteobacteria	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
TLS2_k127_6032608_4	1267005.KB911257_gene1005	7.284e-99	332.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2TS99@28211|Alphaproteobacteria,3N6MF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
TLS2_k127_6032608_10	991905.SL003B_0070	4.683e-49	183.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2U9H5@28211|Alphaproteobacteria,4BQAC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
TLS2_k127_6032608_1	1267005.KB911257_gene1007	4.168e-135	435.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2TT66@28211|Alphaproteobacteria,3N7J0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation	MA20_24795	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
TLS2_k127_6032608_0	1267005.KB911257_gene1008	1.013e-165	527.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2TQQV@28211|Alphaproteobacteria,3N63I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS2_k127_6032608_7	717785.HYPMC_4556	1.106e-66	231.0	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2U987@28211|Alphaproteobacteria,3N6XK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterised protein family (UPF0093)	MA20_24805	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
TLS2_k127_6032608_2	1267005.KB911257_gene1010	2.488e-115	376.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2TRB4@28211|Alphaproteobacteria,3N6B0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
TLS2_k127_6118597_2	547042.BACCOPRO_00852	0.0007044	46.0	COG0790@1|root,COG0790@2|Bacteria,4PHJP@976|Bacteroidetes,2FMF0@200643|Bacteroidia,4AN8D@815|Bacteroidaceae	976|Bacteroidetes	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	Sel1
TLS2_k127_6118597_1	1357272.AVEO02000166_gene2393	1.374e-47	175.0	COG3157@1|root,COG3157@2|Bacteria,1RBTU@1224|Proteobacteria,1S39K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Type VI secretion system effector	hcp	-	-	ko:K06887,ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
TLS2_k127_6118597_0	587753.EY04_18255	6.396e-75	253.0	COG3517@1|root,COG3517@2|Bacteria,1MU5C@1224|Proteobacteria,1RNP7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	type VI secretion protein	impC	-	-	ko:K11900	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	VipB
TLS2_k127_6192246_13	1297865.APJD01000010_gene4865	1.214e-14	74.0	COG1524@1|root,COG1524@2|Bacteria,1N5SF@1224|Proteobacteria,2TU7V@28211|Alphaproteobacteria,3JXCK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	phnA	-	3.11.1.2	ko:K19670	ko00440,map00440	-	R00318	RC01309	ko00000,ko00001,ko01000	-	-	-	Phosphodiest
TLS2_k127_6192246_0	1411123.JQNH01000001_gene390	5.099e-263	815.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TTJP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	phnY	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_6192246_8	1411123.JQNH01000001_gene747	6.2e-94	321.0	COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_6192246_11	1408224.SAMCCGM7_c4406	1.389e-36	147.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2U4QB@28211|Alphaproteobacteria,4BD43@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_6192246_7	1123360.thalar_01465	1.708e-136	447.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	TRAP-type mannitol chloroaromatic compound transport system large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
TLS2_k127_6192246_3	1205680.CAKO01000005_gene3521	5.878e-181	583.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2TRF9@28211|Alphaproteobacteria,2JQEV@204441|Rhodospirillales	204441|Rhodospirillales	P	Na+/Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
TLS2_k127_6192246_5	1040989.AWZU01000027_gene3082	1.403e-174	555.0	COG0520@1|root,COG0520@2|Bacteria,1QU0N@1224|Proteobacteria,2TW6K@28211|Alphaproteobacteria,3JTWT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_6192246_10	1158165.KB898880_gene1563	3.016e-53	195.0	COG5549@1|root,COG5549@2|Bacteria,1RIJW@1224|Proteobacteria,1SIG8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
TLS2_k127_6192246_9	690585.JNNU01000026_gene2557	1.145e-65	229.0	COG1859@1|root,COG1859@2|Bacteria,1RD8B@1224|Proteobacteria,2U7KX@28211|Alphaproteobacteria,4BKXC@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase	kptA	-	-	ko:K07559	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PTS_2-RNA
TLS2_k127_6192246_6	1411123.JQNH01000001_gene3349	6.398e-146	471.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2TSKH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_6192246_4	1411123.JQNH01000001_gene3334	1.629e-180	572.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TQRA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_18570	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_6192246_2	316058.RPB_1747	2.787e-194	625.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JU6X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	MA20_18580	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_6192246_1	1267005.KB911255_gene2618	3.844e-247	769.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TR6K@28211|Alphaproteobacteria,3N6B9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TLS2_k127_6192246_12	1297865.APJD01000007_gene2359	5.004e-19	89.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TTZZ@28211|Alphaproteobacteria,3JVH5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	MA20_17025	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_6232106_5	582899.Hden_0691	3.316e-11	67.0	COG1148@1|root,COG1148@2|Bacteria,1R882@1224|Proteobacteria,2U526@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Pyr_redox_2
TLS2_k127_6232106_3	316057.RPD_4362	4.086e-52	191.0	COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,2U0HE@28211|Alphaproteobacteria,3JUPV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	LysE type translocator	MA20_06410	-	-	-	-	-	-	-	-	-	-	-	LysE
TLS2_k127_6232106_0	582899.Hden_0690	5.416e-261	808.0	COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,2TSIB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
TLS2_k127_6232106_4	290397.Adeh_2482	1.867e-42	164.0	COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,434KP@68525|delta/epsilon subdivisions,2WYXY@28221|Deltaproteobacteria,2Z0W7@29|Myxococcales	28221|Deltaproteobacteria	C	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_6232106_1	582899.Hden_0689	1.622e-146	466.0	COG1150@1|root,COG1150@2|Bacteria,1R7PH@1224|Proteobacteria,2U2FE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
TLS2_k127_6232106_2	1417296.U879_08065	1.514e-64	222.0	COG2044@1|root,COG2044@2|Bacteria,1RGWS@1224|Proteobacteria,2UB97@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
TLS2_k127_6301390_7	648757.Rvan_2373	9.11e-91	310.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2TTUR@28211|Alphaproteobacteria,3N6GA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
TLS2_k127_6301390_5	717785.HYPMC_0026	4.473e-136	449.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2TR81@28211|Alphaproteobacteria,3N63W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_6301390_3	1267005.KB911257_gene726	7.693e-172	548.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria,3N6G5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	acetylornithine	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_6301390_9	1267005.KB911259_gene3715	3.815e-74	255.0	COG3103@1|root,COG4991@2|Bacteria,1RBPM@1224|Proteobacteria,2U6W2@28211|Alphaproteobacteria,3N7E8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1236,SH3_3
TLS2_k127_6301390_6	765698.Mesci_1276	3.183e-112	367.0	COG0500@1|root,COG2226@2|Bacteria,1MV7N@1224|Proteobacteria,2TVGZ@28211|Alphaproteobacteria,43N0E@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_6301390_0	991905.SL003B_0932	6.269e-240	751.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2TR0F@28211|Alphaproteobacteria,4BP70@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
TLS2_k127_6301390_2	1267005.KB911257_gene1131	4.016e-179	567.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2TSHT@28211|Alphaproteobacteria,3N6HI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	EH	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TLS2_k127_6301390_8	582899.Hden_1966	2.123e-90	306.0	COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,2U5K8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Hydrolase_4
TLS2_k127_6301390_1	717785.HYPMC_2897	2.131e-235	731.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2TQZ0@28211|Alphaproteobacteria,3N65X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS2_k127_6301390_4	1267005.KB911258_gene495	9.237e-150	478.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TR8D@28211|Alphaproteobacteria,3N6FP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
TLS2_k127_6301390_10	1267005.KB911258_gene496	4.834e-37	142.0	COG5467@1|root,COG5467@2|Bacteria,1MZRN@1224|Proteobacteria,2UC1G@28211|Alphaproteobacteria,3N79E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1476)	MA20_09035	-	-	-	-	-	-	-	-	-	-	-	DUF1476
TLS2_k127_637149_2	1267005.KB911263_gene1280	7.559e-183	585.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2TQU9@28211|Alphaproteobacteria,3N689@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS2_k127_637149_0	1267005.KB911264_gene3150	9.067e-244	774.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2TS8B@28211|Alphaproteobacteria,3N6EA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	ATP-dependent DNA helicase RecQ	recQ	GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
TLS2_k127_637149_5	1038859.AXAU01000006_gene5567	1.009e-89	299.0	COG0586@1|root,COG0586@2|Bacteria,1R5SJ@1224|Proteobacteria,2UG7E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_637149_7	1121920.AUAU01000006_gene388	4.32e-85	287.0	COG1309@1|root,COG1309@2|Bacteria,3Y4H4@57723|Acidobacteria	57723|Acidobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_N
TLS2_k127_637149_10	1163617.SCD_n02575	1.425e-68	233.0	2E4PM@1|root,32P93@2|Bacteria,1N4SK@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_637149_4	582899.Hden_0988	4.449e-144	465.0	COG1940@1|root,COG1940@2|Bacteria,1MVCI@1224|Proteobacteria,2TUPT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GK	carbohydrate kinase activity	MA20_44035	-	-	-	-	-	-	-	-	-	-	-	ROK
TLS2_k127_637149_3	670307.HYPDE_41488	2.721e-170	539.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2TQZX@28211|Alphaproteobacteria,3N6IB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS2_k127_637149_11	1267005.KB911262_gene3323	2.124e-62	219.0	COG0589@1|root,COG0589@2|Bacteria,1R9XB@1224|Proteobacteria,2U59E@28211|Alphaproteobacteria,3N73H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Universal stress protein family	MA20_23830	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_637149_8	1267005.KB911262_gene3324	2.691e-81	275.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,2TUD1@28211|Alphaproteobacteria,3N6NK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Scaffold protein Nfu NifU	nifU	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
TLS2_k127_637149_9	1267005.KB911262_gene3325	1.949e-76	262.0	COG0778@1|root,COG0778@2|Bacteria,1R9VX@1224|Proteobacteria,2U5B0@28211|Alphaproteobacteria,3N7J1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NADH dehydrogenase NAD(P)H nitroreductase	rutE	-	-	ko:K09019	ko00240,ko01100,map00240,map01100	-	R09289	RC00087	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
TLS2_k127_637149_13	1267005.KB911262_gene3326	1.466e-35	144.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2TTM2@28211|Alphaproteobacteria,3N7AS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Glycoprotease family	yeaZ	-	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TLS2_k127_637149_12	582899.Hden_3482	4.332e-39	153.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2UF5C@28211|Alphaproteobacteria,3N7BH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	FR47-like protein	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
TLS2_k127_637149_6	398525.KB900701_gene6071	1.374e-89	300.0	2E5W4@1|root,330K6@2|Bacteria,1N893@1224|Proteobacteria,2UGUZ@28211|Alphaproteobacteria,3JRW1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
TLS2_k127_637149_1	288000.BBta_2026	6.193e-205	646.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JRKR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_6414326_3	1197906.CAJQ02000020_gene462	6.658e-230	725.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TTB9@28211|Alphaproteobacteria,3JU33@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Carboxyl transferase domain	MA20_27300	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_6414326_18	1267005.KB911260_gene3450	2.376e-13	73.0	COG5509@1|root,COG5509@2|Bacteria,1NG8P@1224|Proteobacteria,2UJB2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1192)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1192
TLS2_k127_6414326_8	1101192.KB910516_gene3671	9.606e-112	371.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TTJV@28211|Alphaproteobacteria,1JSMI@119045|Methylobacteriaceae	28211|Alphaproteobacteria	CH	PFAM D-isomer specific 2-hydroxyacid dehydrogenase catalytic region	gyaR2	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_6414326_2	1267005.KB911256_gene1502	4.858e-254	792.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,3N8K5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	MA20_01895	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS2_k127_6414326_4	1267005.KB911257_gene1096	6.206e-222	695.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,3N6F0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009507,GO:0009536,GO:0010035,GO:0010038,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017076,GO:0019866,GO:0030554,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0046686,GO:0046872,GO:0046914,GO:0048046,GO:0050896,GO:0050897,GO:0055114,GO:0070469,GO:0097159,GO:0097367,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_6414326_5	717785.HYPMC_4524	8.452e-180	571.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,3N63H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_6414326_0	1267005.KB911257_gene1094	0.0	1566.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,3N67P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
TLS2_k127_6414326_6	582899.Hden_3228	6.844e-154	493.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,3N634@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
TLS2_k127_6414326_14	1101190.ARWB01000001_gene234	1.776e-49	191.0	28X2W@1|root,2ZJ1E@2|Bacteria,1R92Z@1224|Proteobacteria,2TS5H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PcfJ
TLS2_k127_6414326_10	159450.NH14_02995	5.443e-100	336.0	COG2141@1|root,COG2141@2|Bacteria,1MVF0@1224|Proteobacteria,2VP68@28216|Betaproteobacteria,1K1EY@119060|Burkholderiaceae	28216|Betaproteobacteria	C	luciferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_6414326_13	1304877.KI519400_gene920	1.348e-51	187.0	COG0607@1|root,COG0607@2|Bacteria,1RHQZ@1224|Proteobacteria,2U9DZ@28211|Alphaproteobacteria,3JY2J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Rhodanese Homology Domain	MA20_01310	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_6414326_11	1381123.AYOD01000001_gene948	1.654e-57	203.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2U956@28211|Alphaproteobacteria,43JX0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	FG	HIT family hydrolase	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
TLS2_k127_6414326_17	1187851.A33M_2731	1.229e-21	99.0	2E5FD@1|root,33072@2|Bacteria,1NBEM@1224|Proteobacteria,2UGG8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Branched-chain amino acid transport	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
TLS2_k127_6414326_15	1131814.JAFO01000001_gene2048	5.377e-45	172.0	COG1296@1|root,COG1296@2|Bacteria,1QFIN@1224|Proteobacteria,2U0SX@28211|Alphaproteobacteria,3EZCV@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	AzlC protein	MA20_36175	-	-	-	-	-	-	-	-	-	-	-	AzlC
TLS2_k127_6414326_1	648757.Rvan_0347	0.0	1204.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,3N627@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS2_k127_6414326_12	1267005.KB911256_gene2017	1.605e-56	199.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2U982@28211|Alphaproteobacteria,3N6W6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
TLS2_k127_6414326_9	1121033.AUCF01000006_gene4238	1.682e-107	361.0	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2TRTM@28211|Alphaproteobacteria,2JRPE@204441|Rhodospirillales	204441|Rhodospirillales	Q	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	-	-	3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
TLS2_k127_6414326_16	1090318.ATTI01000001_gene510	7.805e-29	124.0	2BVGP@1|root,32QVG@2|Bacteria,1MYPP@1224|Proteobacteria,2UA2Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6414326_7	1205680.CAKO01000038_gene1552	1.002e-133	434.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria,2JQXG@204441|Rhodospirillales	204441|Rhodospirillales	S	N-terminal domain of oxidoreductase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
TLS2_k127_6415429_2	1003200.AXXA_05503	7.063e-71	248.0	COG0730@1|root,COG0730@2|Bacteria,1NAFA@1224|Proteobacteria,2W6EW@28216|Betaproteobacteria,3T89S@506|Alcaligenaceae	28216|Betaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_6415429_1	570967.JMLV01000002_gene1922	3.132e-98	335.0	COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,2TU4M@28211|Alphaproteobacteria,2JQ9V@204441|Rhodospirillales	204441|Rhodospirillales	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_6415429_6	42256.RradSPS_2167	1.572e-28	123.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	1.1.1.169,3.1.3.25,3.6.1.55	ko:K00077,ko:K01092,ko:K03574	ko00521,ko00562,ko00770,ko01100,ko01110,ko04070,map00521,map00562,map00770,map01100,map01110,map04070	M00119,M00131	R01185,R01186,R01187,R02472	RC00078,RC00726	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	NUDIX
TLS2_k127_6415429_5	670307.HYPDE_36808	2.078e-44	162.0	COG3492@1|root,COG3492@2|Bacteria,1MZ3I@1224|Proteobacteria,2UC11@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	MA20_03865	-	-	ko:K09948	-	-	-	-	ko00000	-	-	-	DUF1244
TLS2_k127_6415429_0	1125973.JNLC01000013_gene3813	4.081e-104	346.0	COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,2TVK6@28211|Alphaproteobacteria,3JTTE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
TLS2_k127_6415429_3	582899.Hden_0696	2.492e-70	240.0	COG0509@1|root,COG0509@2|Bacteria,1RKRS@1224|Proteobacteria,2UAPN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glycine cleavage H-protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
TLS2_k127_6415429_4	582899.Hden_0695	1.214e-47	179.0	2AKRU@1|root,31BIQ@2|Bacteria,1Q7DM@1224|Proteobacteria,2UEKS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6415429_7	396588.Tgr7_2760	3.972e-14	74.0	COG0500@1|root,COG0500@2|Bacteria,1RDRV@1224|Proteobacteria,1S2T5@1236|Gammaproteobacteria,1WYYI@135613|Chromatiales	135613|Chromatiales	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_6465173_3	1267005.KB911255_gene2622	2.621e-108	362.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TT24@28211|Alphaproteobacteria,3N6R4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S11 family	dacA3	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Peptidase_S11
TLS2_k127_6465173_2	709797.CSIRO_4121	1.637e-131	423.0	COG2043@1|root,COG2043@2|Bacteria,1NR18@1224|Proteobacteria,2TVGP@28211|Alphaproteobacteria,3JU0D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterised ArCR, COG2043	MA20_36865	-	-	-	-	-	-	-	-	-	-	-	DUF169
TLS2_k127_6465173_5	1411123.JQNH01000001_gene138	1.009e-42	163.0	COG0454@1|root,COG1670@1|root,COG0456@2|Bacteria,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2U62V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_6465173_0	1267005.KB911255_gene2666	2.538e-203	640.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria,3N7M1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Mycolic acid cyclopropane synthetase	cfa	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS2_k127_6465173_4	1120983.KB894575_gene468	3.349e-107	355.0	COG4176@1|root,COG4176@2|Bacteria,1MUM4@1224|Proteobacteria,2TRF1@28211|Alphaproteobacteria,1JNXC@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	L-proline glycine betaine ABC transport system permease protein ProW	-	-	-	ko:K02001,ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
TLS2_k127_6465173_1	1211115.ALIQ01000189_gene838	8.59e-136	441.0	COG2113@1|root,COG2113@2|Bacteria,1QU64@1224|Proteobacteria,2TZ6V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
TLS2_k127_6572436_1	717785.HYPMC_4539	1.25e-231	726.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,3N6GV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
TLS2_k127_6572436_18	1267005.KB911257_gene1055	1.629e-45	170.0	COG5468@1|root,COG5468@2|Bacteria,1MXDR@1224|Proteobacteria,2TUMW@28211|Alphaproteobacteria,3N8WH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Lipopolysaccharide-assembly	-	-	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptE
TLS2_k127_6572436_11	1267005.KB911257_gene1056	2.705e-101	342.0	COG1466@1|root,COG1466@2|Bacteria,1R8PA@1224|Proteobacteria,2U1KQ@28211|Alphaproteobacteria,3N6YC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
TLS2_k127_6572436_9	670307.HYPDE_39798	1.131e-115	383.0	COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria,3N6AC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	pfkB family carbohydrate kinase	iolC	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS2_k127_6572436_6	1267005.KB911257_gene1020	1.121e-147	476.0	COG1072@1|root,COG1072@2|Bacteria,1MV3M@1224|Proteobacteria,2TS7E@28211|Alphaproteobacteria,3N64A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Pantothenic acid kinase	coaA	-	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
TLS2_k127_6572436_21	1267005.KB911257_gene1019	4.478e-33	132.0	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,2UBU3@28211|Alphaproteobacteria,3N78B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Phosphoribosyl-ATP pyrophosphohydrolase	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
TLS2_k127_6572436_5	1211115.ALIQ01000212_gene3272	5.662e-148	480.0	COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,2TR1C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0226 ABC-type phosphate transport system, periplasmic component	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
TLS2_k127_6572436_10	1121396.KB893068_gene1482	2.72e-110	374.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2MHPU@213118|Desulfobacterales	28221|Deltaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3708
TLS2_k127_6572436_2	1211115.ALIQ01000212_gene3274	7.349e-184	592.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2TQYQ@28211|Alphaproteobacteria,3NBPQ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
TLS2_k127_6572436_7	1267005.KB911257_gene1082	5.938e-135	433.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2TQX9@28211|Alphaproteobacteria,3N6BG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TLS2_k127_6572436_14	582899.Hden_0955	6.171e-78	263.0	COG1846@1|root,COG1846@2|Bacteria,1RA1V@1224|Proteobacteria,2U5W6@28211|Alphaproteobacteria,3N6ZY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	mucS	-	-	-	-	-	-	-	-	-	-	-	HTH_27
TLS2_k127_6572436_12	1267005.KB911259_gene3701	1.798e-98	333.0	COG1024@1|root,COG1024@2|Bacteria,1MU0B@1224|Proteobacteria,2TQW3@28211|Alphaproteobacteria,3N70K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	hibch	-	3.1.2.4,4.2.1.17	ko:K01692,ko:K05605	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212	M00013,M00032,M00087	R03026,R03045,R03158,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05064,R05595,R06411,R06412,R06942,R08093	RC00004,RC00014,RC00137,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_2
TLS2_k127_6572436_17	1267005.KB911259_gene3702	2.736e-57	217.0	COG3921@1|root,COG3921@2|Bacteria	2|Bacteria	S	Extensin-like protein C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Extensin-like_C
TLS2_k127_6572436_15	1267005.KB911259_gene4029	3.273e-74	256.0	COG2249@1|root,COG2249@2|Bacteria,1RA5X@1224|Proteobacteria,2U7JU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	NADPH-quinone reductase (modulator of drug activity B)	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
TLS2_k127_6572436_3	1205680.CAKO01000002_gene3059	1.047e-168	541.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,2JSA1@204441|Rhodospirillales	204441|Rhodospirillales	C	Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain	-	-	-	-	-	-	-	-	-	-	-	-	FMN_dh
TLS2_k127_6572436_8	1159870.KB907784_gene3183	3.719e-130	428.0	COG3135@1|root,COG3135@2|Bacteria,1MUS1@1224|Proteobacteria,2VPET@28216|Betaproteobacteria,3T49Z@506|Alcaligenaceae	28216|Betaproteobacteria	Q	Benzoate membrane transport protein	-	-	-	ko:K05782	-	-	-	-	ko00000,ko02000	2.A.46.1	-	-	BenE
TLS2_k127_6572436_20	78245.Xaut_3071	9.896e-39	150.0	2AS6X@1|root,31HJW@2|Bacteria,1RGYJ@1224|Proteobacteria,2U9UH@28211|Alphaproteobacteria,3EZJS@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2852)	MA20_04040	-	-	-	-	-	-	-	-	-	-	-	DUF2852
TLS2_k127_6572436_13	1187851.A33M_2066	2.358e-83	282.0	COG1309@1|root,COG1309@2|Bacteria,1MUUY@1224|Proteobacteria,2TUIH@28211|Alphaproteobacteria,3FDHR@34008|Rhodovulum	28211|Alphaproteobacteria	K	WHG domain	MA20_04045	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TLS2_k127_6572436_4	1510531.JQJJ01000009_gene859	4.676e-154	499.0	COG0477@1|root,COG2814@2|Bacteria,1R3YS@1224|Proteobacteria,2TT98@28211|Alphaproteobacteria,3JRGC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Transmembrane secretion effector	MA20_36670	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS2_k127_6572436_0	1429916.X566_16350	1.909e-277	859.0	COG2159@1|root,COG2159@2|Bacteria,1Q4XY@1224|Proteobacteria,2U25S@28211|Alphaproteobacteria,3JUPG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_6572436_19	1280947.HY30_06435	4.323e-45	179.0	COG1192@1|root,COG1192@2|Bacteria,1NY4Z@1224|Proteobacteria,2USTY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Anion-transporting ATPase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS2_k127_6575913_12	1267005.KB911258_gene457	9.442e-55	210.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3N6FA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	cckA	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
TLS2_k127_6575913_14	717785.HYPMC_1394	3.394e-25	111.0	COG3115@1|root,COG3115@2|Bacteria,1N9KJ@1224|Proteobacteria,2TUCT@28211|Alphaproteobacteria,3N7ER@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Flagellar biosynthesis protein, FliO	-	-	-	-	-	-	-	-	-	-	-	-	FliO
TLS2_k127_6575913_4	1267005.KB911258_gene455	2.682e-181	598.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria,3N7EE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Mechanosensitive ion channel	kefA	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	DUF3772,MS_channel
TLS2_k127_6575913_8	1380394.JADL01000001_gene1990	3.905e-109	358.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TUKJ@28211|Alphaproteobacteria,2JVIA@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
TLS2_k127_6575913_13	1205680.CAKO01000039_gene440	1.815e-46	175.0	COG2050@1|root,COG2050@2|Bacteria,1PP3J@1224|Proteobacteria,2U5E4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	protein possibly involved in aromatic compounds catabolism	MA20_28520	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_6575913_9	1267005.KB911263_gene1309	8.482e-105	346.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2TU7F@28211|Alphaproteobacteria,3N7HY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
TLS2_k127_6575913_15	288000.BBta_5865	2.999e-12	79.0	COG0790@1|root,COG0790@2|Bacteria,1R74Z@1224|Proteobacteria,2U4V6@28211|Alphaproteobacteria,3JV9X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	COG0790 FOG TPR repeat, SEL1 subfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6575913_7	1411123.JQNH01000001_gene1653	1.882e-121	402.0	COG2358@1|root,COG2358@2|Bacteria,1MWSG@1224|Proteobacteria,2TSVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
TLS2_k127_6575913_3	1298867.AUES01000001_gene1663	5.039e-201	636.0	COG1168@1|root,COG1168@2|Bacteria,1MY33@1224|Proteobacteria,2TR29@28211|Alphaproteobacteria,3K2MT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class I and II	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_6575913_5	1298867.AUES01000004_gene632	1.816e-133	429.0	COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2TSU3@28211|Alphaproteobacteria,3JTEG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Peptidase C26	puuD	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
TLS2_k127_6575913_10	1007105.PT7_2711	5.215e-77	271.0	COG2267@1|root,COG2267@2|Bacteria,1R24N@1224|Proteobacteria,2WI9C@28216|Betaproteobacteria,3T9M9@506|Alcaligenaceae	28216|Betaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_6575913_0	1121861.KB899913_gene2217	2.78e-312	969.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JQSU@204441|Rhodospirillales	204441|Rhodospirillales	EQ	Hydantoinase/oxoprolinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydant_A_N,Hydantoinase_A
TLS2_k127_6575913_1	1121861.KB899913_gene2218	6.335e-294	909.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,2JQP4@204441|Rhodospirillales	204441|Rhodospirillales	EQ	Hydantoinase B/oxoprolinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydantoinase_B
TLS2_k127_6575913_2	1429916.X566_16185	1.357e-219	693.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria,3JQQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_6575913_6	1336243.JAEA01000017_gene609	4.236e-122	408.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TSKV@28211|Alphaproteobacteria,1JT9A@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_6575913_11	991905.SL003B_3089	3.788e-61	215.0	COG0665@1|root,COG0665@2|Bacteria,1R7JH@1224|Proteobacteria,2U1VP@28211|Alphaproteobacteria,4BRWU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS2_k127_6582317_8	717785.HYPMC_3821	3.206e-16	80.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2TT3I@28211|Alphaproteobacteria,3N6A9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179,ko:K06125	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117,M00128	R05000,R05615,R05616,R07273	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TLS2_k127_6582317_7	1120956.JHZK01000024_gene1072	2.064e-30	123.0	COG0483@1|root,COG0483@2|Bacteria,1N7D7@1224|Proteobacteria,2UF6T@28211|Alphaproteobacteria,1JPDK@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Domain of unknown function (DUF4170)	MA20_05805	-	-	-	-	-	-	-	-	-	-	-	DUF4170
TLS2_k127_6582317_1	1267005.KB911257_gene1022	8.166e-183	578.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,3N6AE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_6582317_4	1267005.KB911256_gene1918	1.841e-112	372.0	COG2267@1|root,COG2267@2|Bacteria,1NTH9@1224|Proteobacteria,2TWFW@28211|Alphaproteobacteria,3N777@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
TLS2_k127_6582317_6	582899.Hden_1383	1.055e-96	329.0	COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,2TTEI@28211|Alphaproteobacteria,3N669@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_6582317_5	1410620.SHLA_26c000730	1.29e-100	337.0	28H5T@1|root,2Z7IB@2|Bacteria,1N7V9@1224|Proteobacteria,2TTZQ@28211|Alphaproteobacteria,4BA3U@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6582317_9	1122132.AQYH01000003_gene3174	2.373e-08	60.0	2EFTF@1|root,339JI@2|Bacteria,1NIP0@1224|Proteobacteria,2UJJ4@28211|Alphaproteobacteria,4BH0Z@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2842)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2842
TLS2_k127_6582317_2	1174504.AJTN02000153_gene992	5.034e-132	441.0	COG1062@1|root,COG1062@2|Bacteria,1TP8E@1239|Firmicutes,4HAH9@91061|Bacilli,1ZAXJ@1386|Bacillus	91061|Bacilli	C	Zinc-binding dehydrogenase	adhC	-	1.1.1.1,1.1.1.90	ko:K00001,ko:K00055	ko00010,ko00071,ko00350,ko00360,ko00622,ko00623,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00360,map00622,map00623,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	M00537,M00538	R00623,R00754,R01763,R02124,R02611,R04304,R04805,R04880,R05233,R05234,R05282,R05347,R05348,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_6582317_3	1304877.KI519399_gene2063	9.13e-122	401.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,2TRBC@28211|Alphaproteobacteria,3JSHY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	romA	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_6582317_0	196490.AUEZ01000017_gene3191	1.548e-255	798.0	COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,2TS3K@28211|Alphaproteobacteria,3JUFH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	MA20_06195	-	4.1.1.7	ko:K01576	ko00627,ko01120,map00627,map01120	-	R01764,R02672	RC00595	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_6583658_2	1197906.CAJQ02000023_gene2358	3.478e-130	419.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2TS04@28211|Alphaproteobacteria,3JVVK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	-	-	-	-	-	-	-	-	-	-	-	-	Histidinol_dh
TLS2_k127_6583658_4	1123053.AUDG01000030_gene1048	6.316e-62	233.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1S4J0@1236|Gammaproteobacteria,1WY5K@135613|Chromatiales	135613|Chromatiales	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
TLS2_k127_6583658_1	189753.AXAS01000036_gene7759	5.168e-131	426.0	COG1995@1|root,COG1995@2|Bacteria,1MXGJ@1224|Proteobacteria,2TUEU@28211|Alphaproteobacteria,3JU0Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Pyridoxal phosphate biosynthetic protein PdxA	pdxA_2	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
TLS2_k127_6583658_3	935557.ATYB01000008_gene5168	1.573e-106	355.0	COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,2TRQX@28211|Alphaproteobacteria,4BMQT@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_6583658_0	1333998.M2A_2881	1.375e-137	443.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRA0@28211|Alphaproteobacteria,4BPJ2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Carboxyl transferase domain	mccB	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_6587850_27	1267005.KB911255_gene2395	1.922e-44	177.0	COG0542@1|root,COG0542@2|Bacteria,1NXPQ@1224|Proteobacteria,2UTUZ@28211|Alphaproteobacteria,3N8QT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Clp amino terminal domain, pathogenicity island component	-	-	-	-	-	-	-	-	-	-	-	-	Clp_N
TLS2_k127_6587850_31	1267005.KB911257_gene919	5.291e-29	128.0	2CKRE@1|root,32SCW@2|Bacteria,1MWRU@1224|Proteobacteria,2TSRM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2865)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2865
TLS2_k127_6587850_19	1267005.KB911257_gene680	1.183e-66	229.0	COG1051@1|root,COG1051@2|Bacteria,1QUNH@1224|Proteobacteria,2TW1V@28211|Alphaproteobacteria,3N9IR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Nudix hydrolase	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,NUDIX_4
TLS2_k127_6587850_3	648757.Rvan_0068	2.184e-206	651.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	unusual protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
TLS2_k127_6587850_21	1267005.KB911257_gene903	1.032e-61	220.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2U71N@28211|Alphaproteobacteria,3N6XR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	EVE domain	MA20_25125	-	-	-	-	-	-	-	-	-	-	-	EVE
TLS2_k127_6587850_23	1168059.KB899087_gene754	2.032e-51	192.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,2U9DR@28211|Alphaproteobacteria,3EZUN@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
TLS2_k127_6587850_5	1144343.PMI41_04201	3.257e-154	495.0	COG0346@1|root,COG0346@2|Bacteria,1MX8U@1224|Proteobacteria,2TV0W@28211|Alphaproteobacteria,43HMM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	mhqA	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_6587850_10	1231185.BAMP01000141_gene486	3.73e-99	324.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,43J8P@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS2_k127_6587850_14	1449351.RISW2_11425	7.289e-80	268.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U5Q0@28211|Alphaproteobacteria,4KMHN@93682|Roseivivax	28211|Alphaproteobacteria	O	This stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
TLS2_k127_6587850_2	1231190.NA8A_21891	1.762e-223	701.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,2TUTC@28211|Alphaproteobacteria,43GVY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
TLS2_k127_6587850_1	717785.HYPMC_3211	1.592e-278	865.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2TRN0@28211|Alphaproteobacteria,3N630@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
TLS2_k127_6587850_33	1101195.Meth11DRAFT_0475	4.486e-22	99.0	2E5PA@1|root,330E0@2|Bacteria,1PJRE@1224|Proteobacteria,2W851@28216|Betaproteobacteria,2KNYY@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6587850_17	670307.HYPDE_37823	4.472e-70	239.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2U5CS@28211|Alphaproteobacteria,3N6VX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
TLS2_k127_6587850_11	258594.RPA2425	1.349e-97	328.0	COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2U5X1@28211|Alphaproteobacteria,3JSH0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Carboxylesterase family	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
TLS2_k127_6587850_7	1267005.KB911258_gene474	2.374e-122	404.0	COG2995@1|root,COG2995@2|Bacteria,1NGIG@1224|Proteobacteria,2UGUB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
TLS2_k127_6587850_25	1267005.KB911258_gene475	2.351e-48	175.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2U9QB@28211|Alphaproteobacteria,3N755@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the glutaredoxin family. Monothiol subfamily	grlA	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
TLS2_k127_6587850_15	1380394.JADL01000003_gene4758	1.881e-77	269.0	COG0412@1|root,COG0412@2|Bacteria,1QZFP@1224|Proteobacteria	1224|Proteobacteria	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6587850_24	591157.SSLG_06214	1.167e-48	185.0	COG1082@1|root,COG1082@2|Bacteria,2IJGM@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_6587850_30	717785.HYPMC_1413	6.324e-31	123.0	COG0271@1|root,COG0271@2|Bacteria,1R3MM@1224|Proteobacteria,2UBUW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Belongs to the BolA IbaG family	bolA2	-	-	-	-	-	-	-	-	-	-	-	BolA
TLS2_k127_6587850_12	113395.AXAI01000005_gene3816	4.053e-97	331.0	COG0667@1|root,COG0667@2|Bacteria,1R5BH@1224|Proteobacteria,2TS0A@28211|Alphaproteobacteria,3JU90@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_6587850_20	1038860.AXAP01000010_gene7797	1.656e-66	237.0	COG2084@1|root,COG2084@2|Bacteria,1MV27@1224|Proteobacteria,2TTCZ@28211|Alphaproteobacteria,3JT36@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Domain of unknown function (DUF1932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,NAD_binding_2
TLS2_k127_6587850_6	1267005.KB911260_gene3439	2.469e-132	428.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2TTFE@28211|Alphaproteobacteria,3N657@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF815)	MA20_41470	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
TLS2_k127_6587850_22	1205680.CAKO01000037_gene1183	2.475e-55	198.0	COG5507@1|root,COG5507@2|Bacteria,1RH3Q@1224|Proteobacteria,2U9SM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM NIPSNAP family containing protein	MA20_41850	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
TLS2_k127_6587850_9	1267005.KB911258_gene492	2.13e-106	349.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria,3N6NC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
TLS2_k127_6587850_29	1267005.KB911258_gene494	2.449e-31	125.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,3N77Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
TLS2_k127_6587850_8	1547437.LL06_08770	2.173e-116	384.0	COG0702@1|root,COG0702@2|Bacteria,1QU1T@1224|Proteobacteria,2TTHK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_6587850_28	670307.HYPDE_33963	1.159e-37	154.0	COG0810@1|root,COG0810@2|Bacteria,1PVW4@1224|Proteobacteria,2V740@28211|Alphaproteobacteria,3N8Y7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TLS2_k127_6587850_32	414684.RC1_2221	2.609e-25	111.0	COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,2U93G@28211|Alphaproteobacteria,2JT7K@204441|Rhodospirillales	204441|Rhodospirillales	S	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
TLS2_k127_6587850_0	1429916.X566_07360	0.0	1225.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,3JU9H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TLS2_k127_6587850_16	1502851.FG93_03639	5.811e-71	246.0	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,2U728@28211|Alphaproteobacteria,3JY01@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
TLS2_k127_6587850_13	1267005.KB911258_gene334	1.63e-90	310.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TSRF@28211|Alphaproteobacteria,3N64W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	ET	Belongs to the bacterial solute-binding protein 3 family	-	-	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
TLS2_k127_6587850_18	717785.HYPMC_1118	8.666e-70	248.0	29APY@1|root,2ZXPR@2|Bacteria,1R817@1224|Proteobacteria,2TSBC@28211|Alphaproteobacteria,3N8C4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1849)	MA20_36210	-	-	-	-	-	-	-	-	-	-	-	DUF1849
TLS2_k127_6587850_4	582899.Hden_0030	5.604e-175	559.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2TT0J@28211|Alphaproteobacteria,3N6CY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_6587850_26	1267005.KB911257_gene1080	4.876e-47	171.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,3N6CS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Two component transcriptional regulator PhoB, winged helix family	phoB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_6604416_12	670307.HYPDE_29403	1.441e-33	134.0	2A2JU@1|root,30QXU@2|Bacteria,1N7N4@1224|Proteobacteria,2TTU2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_08245	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6604416_13	648757.Rvan_0688	3.373e-29	128.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2U08T@28211|Alphaproteobacteria,3N72M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Squalene/phytoene synthase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291,ko:K18163	ko00906,ko01062,ko01100,ko01110,ko04714,map00906,map01062,map01100,map01110,map04714	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	SQS_PSY
TLS2_k127_6604416_16	1333998.M2A_0481	5.895e-19	94.0	COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,2U7B1@28211|Alphaproteobacteria,4BRWK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
TLS2_k127_6604416_11	1380350.JIAP01000009_gene5681	4.064e-38	146.0	COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,2UAJD@28211|Alphaproteobacteria,43JZE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
TLS2_k127_6604416_4	717785.HYPMC_2675	1.072e-122	402.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2TSFW@28211|Alphaproteobacteria,3N8AQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_6604416_1	717785.HYPMC_2676	2.185e-221	698.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,3N696@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_6604416_14	1131814.JAFO01000001_gene2723	5.203e-29	122.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2UBZ6@28211|Alphaproteobacteria,3EZPQ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TLS2_k127_6604416_5	1121106.JQKB01000021_gene1727	1.79e-109	365.0	COG0702@1|root,COG0702@2|Bacteria,1QU1T@1224|Proteobacteria,2TTHK@28211|Alphaproteobacteria,2JYW2@204441|Rhodospirillales	28211|Alphaproteobacteria	GM	NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_6604416_0	1267005.KB911258_gene500	1.544e-242	753.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,3N6DZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
TLS2_k127_6604416_2	1411123.JQNH01000001_gene3180	7.026e-172	542.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2TQKN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Prokaryotic protein of	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
TLS2_k127_6604416_3	1054213.HMPREF9946_04068	1.675e-156	502.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2JPY3@204441|Rhodospirillales	204441|Rhodospirillales	S	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_6604416_9	305700.B447_08223	1.15e-76	272.0	COG1226@1|root,2Z7ZD@2|Bacteria,1MXKM@1224|Proteobacteria,2W18F@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Polycystin cation channel	-	-	-	ko:K08714	-	-	-	-	ko00000,ko02000	1.A.1.14	-	-	Ion_trans
TLS2_k127_6604416_10	1267005.KB911257_gene677	1.028e-71	252.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,3N6YT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Phosphoribosyl transferase domain	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
TLS2_k127_6604416_15	1211115.ALIQ01000139_gene1321	3.091e-28	117.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria,3NBHN@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
TLS2_k127_6604416_8	402881.Plav_2260	3.475e-81	286.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2TTXU@28211|Alphaproteobacteria,1JN5N@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Multi-copper polyphenol oxidoreductase laccase	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
TLS2_k127_6604416_6	1267005.KB911256_gene1488	5.136e-85	297.0	2E5ZA@1|root,330NT@2|Bacteria,1NDA4@1224|Proteobacteria,2UG06@28211|Alphaproteobacteria,3N8QV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6604416_7	1121861.KB899921_gene3036	1.579e-82	279.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2TS04@28211|Alphaproteobacteria	1224|Proteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
TLS2_k127_6617999_0	1054213.HMPREF9946_00312	0.0	1274.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,2JR6A@204441|Rhodospirillales	204441|Rhodospirillales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
TLS2_k127_6617999_3	1502851.FG93_02161	2.148e-107	355.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2U1KV@28211|Alphaproteobacteria,3JWZH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_6617999_1	1502851.FG93_02160	1.743e-155	499.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2U2T4@28211|Alphaproteobacteria,3JX5Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
TLS2_k127_6617999_2	883078.HMPREF9695_00654	8.432e-145	469.0	COG1524@1|root,COG1524@2|Bacteria,1N5SF@1224|Proteobacteria,2TU7V@28211|Alphaproteobacteria,3JXCK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	phnA	-	3.11.1.2	ko:K19670	ko00440,map00440	-	R00318	RC01309	ko00000,ko00001,ko01000	-	-	-	Phosphodiest
TLS2_k127_6621463_6	1121861.KB899912_gene987	1.007e-39	151.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSMN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	MA20_03535	-	1.1.1.29,1.1.1.399,1.1.1.95	ko:K00018,ko:K00058	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020,M00346	R00717,R01388,R01513	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_6621463_1	1121106.JQKB01000027_gene1879	2.396e-176	561.0	COG1063@1|root,COG1063@2|Bacteria,1QTU5@1224|Proteobacteria,2TW9Q@28211|Alphaproteobacteria,2JQP9@204441|Rhodospirillales	204441|Rhodospirillales	E	Alanine dehydrogenase/PNT, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_6621463_0	316057.RPD_3302	8.252e-275	852.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2TSMD@28211|Alphaproteobacteria,3JVCG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Acyl-CoA reductase (LuxC)	mmsA	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008150,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_6621463_4	1205680.CAKO01000002_gene2551	7.173e-93	308.0	COG0625@1|root,COG0625@2|Bacteria,1REDI@1224|Proteobacteria,2TR9W@28211|Alphaproteobacteria,2JTZ7@204441|Rhodospirillales	204441|Rhodospirillales	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C,GST_C_2,GST_N
TLS2_k127_6621463_2	1205680.CAKO01000007_gene4278	1.099e-121	403.0	COG1524@1|root,COG1524@2|Bacteria,1PTI0@1224|Proteobacteria	1224|Proteobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_6621463_7	439375.Oant_3355	8.665e-22	100.0	2ECEB@1|root,336CK@2|Bacteria,1N8WY@1224|Proteobacteria,2UHJ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6621463_3	448385.sce3996	1.06e-102	341.0	COG1396@1|root,COG1396@2|Bacteria,1MWUC@1224|Proteobacteria,430XD@68525|delta/epsilon subdivisions,2WW2B@28221|Deltaproteobacteria,2YVFP@29|Myxococcales	28221|Deltaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
TLS2_k127_6621463_5	1231392.OCGS_2830	5.491e-44	160.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_6633752_9	1168059.KB899087_gene2469	9.271e-56	196.0	COG2218@1|root,COG2218@2|Bacteria,1MUUQ@1224|Proteobacteria,2TSRA@28211|Alphaproteobacteria,3EY5R@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	GXGXG motif	glxC	-	2.1.1.21	ko:K22082	ko00680,ko01120,map00680,map01120	-	R01586	RC00554	ko00000,ko00001,ko01000	-	-	-	GXGXG
TLS2_k127_6633752_1	1131814.JAFO01000001_gene2990	1.874e-244	766.0	COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2TRWC@28211|Alphaproteobacteria,3EYYK@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	IMP dehydrogenase / GMP reductase domain	glxD	-	2.1.1.21	ko:K22083	ko00680,ko01120,map00680,map01120	-	R01586	RC00554	ko00000,ko00001,ko01000	-	-	-	Glu_synthase
TLS2_k127_6633752_14	414684.RC1_0766	4.492e-11	69.0	COG3453@1|root,COG3453@2|Bacteria,1N9AF@1224|Proteobacteria,2UG4C@28211|Alphaproteobacteria,2JZD0@204441|Rhodospirillales	204441|Rhodospirillales	S	Putative phosphatase (DUF442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF442
TLS2_k127_6633752_2	438753.AZC_1499	1.386e-208	657.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TTWE@28211|Alphaproteobacteria,3EYP6@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Glutamine synthetase, catalytic domain	glnT	-	6.3.1.2,6.3.4.12	ko:K01915,ko:K01949	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
TLS2_k127_6633752_11	670307.HYPDE_35338	1.356e-51	186.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2U72U@28211|Alphaproteobacteria,3N716@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	FeS assembly SUF system protein	MA20_30700	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
TLS2_k127_6633752_3	911045.PSE_3002	7.557e-186	594.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2TRNY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
TLS2_k127_6633752_4	717785.HYPMC_1097	6.076e-137	452.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2TTK9@28211|Alphaproteobacteria,3N6Z9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	FeS assembly protein SufD	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
TLS2_k127_6633752_5	717785.HYPMC_1096	1.064e-129	417.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2TS8T@28211|Alphaproteobacteria,3N6M3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	FeS assembly ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
TLS2_k127_6633752_0	876269.ARWA01000001_gene2126	3.493e-275	854.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2TRU6@28211|Alphaproteobacteria,3NA79@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	Uncharacterized protein family (UPF0051)	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TLS2_k127_6633752_6	717785.HYPMC_1094	6.84e-116	392.0	COG1104@1|root,COG1959@1|root,COG1104@2|Bacteria,COG1959@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,3N6PP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class-V	nifS	GO:0000096,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006464,GO:0006520,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0018282,GO:0018283,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031071,GO:0031163,GO:0031974,GO:0031981,GO:0032324,GO:0034641,GO:0036211,GO:0042278,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS2_k127_6633752_13	1267005.KB911256_gene1981	6.485e-42	159.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2U5B9@28211|Alphaproteobacteria,3N92S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	iscR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
TLS2_k127_6633752_7	717785.HYPMC_1092	1.017e-110	363.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2TRMI@28211|Alphaproteobacteria,3N6BC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	QU41_16170	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
TLS2_k127_6633752_8	1267005.KB911255_gene2511	2.118e-90	308.0	COG3217@1|root,COG3217@2|Bacteria,1MVSP@1224|Proteobacteria,2U1ST@28211|Alphaproteobacteria,3N8FU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	MOSC N-terminal beta barrel domain	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
TLS2_k127_6633752_10	582899.Hden_3483	1.131e-54	196.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2U6ZS@28211|Alphaproteobacteria,3N703@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_6633752_12	1432050.IE4771_CH04120	4.63e-50	186.0	COG1434@1|root,COG1434@2|Bacteria,1RHMV@1224|Proteobacteria,2U957@28211|Alphaproteobacteria,4B7AZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	DUF218 domain	MA20_20455	-	-	-	-	-	-	-	-	-	-	-	DUF218
TLS2_k127_6633752_15	670307.HYPDE_37543	8.86e-06	48.0	COG2177@1|root,COG2177@2|Bacteria,1MXKQ@1224|Proteobacteria,2TSNT@28211|Alphaproteobacteria,3N6YI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Cell division protein	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
TLS2_k127_6641857_11	331869.BAL199_01589	1.291e-34	132.0	COG1173@1|root,COG1173@2|Bacteria,1MVER@1224|Proteobacteria,2TRB3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_6641857_3	331869.BAL199_01594	4.363e-155	500.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,4BRBM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0444 ABC-type dipeptide oligopeptide nickel transport system, ATPase component	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_6641857_4	331869.BAL199_01599	4.737e-153	505.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,4BPZZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_6641857_8	384765.SIAM614_23532	7.754e-112	374.0	COG1349@1|root,COG1349@2|Bacteria,1MUJG@1224|Proteobacteria,2TR8U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG1349 Transcriptional regulators of sugar metabolism	glpR	-	-	ko:K02444	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
TLS2_k127_6641857_1	1207063.P24_01966	9.431e-199	631.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,2JQAF@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TLS2_k127_6641857_6	1238182.C882_1862	2.257e-144	468.0	COG3839@1|root,COG3839@2|Bacteria,1MX8G@1224|Proteobacteria,2TSXF@28211|Alphaproteobacteria,2JPWQ@204441|Rhodospirillales	204441|Rhodospirillales	G	TOBE domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,TOBE_2
TLS2_k127_6641857_2	1122132.AQYH01000008_gene2445	3.42e-156	499.0	COG3839@1|root,COG3839@2|Bacteria,1MU7W@1224|Proteobacteria,2TQNF@28211|Alphaproteobacteria,4B77H@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the ABC transporter superfamily	MA20_44790	-	-	ko:K17325	ko02010,map02010	M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.35	-	-	ABC_tran,TOBE_2
TLS2_k127_6641857_7	744980.TRICHSKD4_0404	3.975e-143	466.0	COG1175@1|root,COG1175@2|Bacteria,1MVAZ@1224|Proteobacteria,2TRWF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG1175 ABC-type sugar transport systems permease components	-	-	-	ko:K17322	ko02010,map02010	M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.35	-	-	BPD_transp_1
TLS2_k127_6641857_5	1469245.JFBG01000044_gene1867	1.518e-144	462.0	COG0395@1|root,COG0395@2|Bacteria,1MVRG@1224|Proteobacteria,1RSNC@1236|Gammaproteobacteria,1X24V@135613|Chromatiales	135613|Chromatiales	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17323	ko02010,map02010	M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.35	-	-	BPD_transp_1
TLS2_k127_6641857_12	1211777.BN77_4270	4.805e-34	133.0	COG5477@1|root,COG5477@2|Bacteria,1N7WT@1224|Proteobacteria,2UBTZ@28211|Alphaproteobacteria,4BFBA@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Small integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2160
TLS2_k127_6641857_0	384765.SIAM614_22832	5.664e-310	956.0	COG1653@1|root,COG1653@2|Bacteria,1MV8A@1224|Proteobacteria,2TTPV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1653 ABC-type sugar transport system, periplasmic component	MA20_44770	-	-	ko:K17321	ko02010,map02010	M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.35	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_6641857_10	396588.Tgr7_0144	5.118e-66	239.0	COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,1RSF8@1236|Gammaproteobacteria,1WZCT@135613|Chromatiales	135613|Chromatiales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_6641857_9	709797.CSIRO_3898	2.471e-81	278.0	COG2267@1|root,COG3710@1|root,COG2267@2|Bacteria,COG3710@2|Bacteria,1QTZ6@1224|Proteobacteria,2TWKD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS2_k127_6648610_13	1297569.MESS2_80074	4.632e-36	140.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,43HN3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the GcvT family	soxA	-	1.5.3.1,1.5.99.5	ko:K00302,ko:K22086	ko00260,ko00680,ko01100,ko01120,map00260,map00680,map01100,map01120	-	R00609,R00610	RC00060,RC00190,RC00557	ko00000,ko00001,ko01000	-	-	-	FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
TLS2_k127_6648610_14	272630.MexAM1_META1p1547	1.579e-28	123.0	COG4311@1|root,COG4311@2|Bacteria,1N8ED@1224|Proteobacteria,2UFIN@28211|Alphaproteobacteria,1JVE5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Sarcosine oxidase, delta subunit	soxD	-	1.5.3.1,1.5.99.5	ko:K00304,ko:K22085	ko00260,ko00680,ko01100,ko01120,map00260,map00680,map01100,map01120	-	R00609,R00610	RC00060,RC00190,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxD
TLS2_k127_6648610_3	1502851.FG93_00742	2.682e-228	712.0	COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,2TRM7@28211|Alphaproteobacteria,3JUTE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	soxB2	-	1.5.3.1,1.5.99.5	ko:K00303,ko:K22084	ko00260,ko00680,ko01100,ko01120,map00260,map00680,map01100,map01120	-	R00609,R00610	RC00060,RC00190,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
TLS2_k127_6648610_11	426117.M446_5039	4.104e-90	303.0	COG0179@1|root,COG0179@2|Bacteria,1R4GE@1224|Proteobacteria,2TTZ5@28211|Alphaproteobacteria,1JV48@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	Protein of unknown function (DUF2848)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2848
TLS2_k127_6648610_9	1267005.KB911255_gene2889	9.144e-102	335.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2U59K@28211|Alphaproteobacteria,3N6V1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
TLS2_k127_6648610_8	670307.HYPDE_28428	9.098e-123	407.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria,3N6RA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Ami_3	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
TLS2_k127_6648610_1	1411123.JQNH01000001_gene2395	4.847e-262	814.0	COG0747@1|root,COG0747@2|Bacteria,1MWBH@1224|Proteobacteria,2TTF4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_6648610_6	246200.SPO1211	8.437e-144	464.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRH6@28211|Alphaproteobacteria,4NCWZ@97050|Ruegeria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	MA20_32335	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_6648610_7	246200.SPO1212	2.966e-128	416.0	COG1173@1|root,COG1173@2|Bacteria,1MVER@1224|Proteobacteria,2TRB3@28211|Alphaproteobacteria,4ND35@97050|Ruegeria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_6648610_2	1411123.JQNH01000001_gene2398	3.593e-238	749.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_6648610_16	1287116.X734_26915	4.164e-15	80.0	COG1977@1|root,COG1977@2|Bacteria,1NN1V@1224|Proteobacteria,2UJVE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS2_k127_6648610_0	1469245.JFBG01000086_gene1608	0.0	1067.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,1RN40@1236|Gammaproteobacteria,1X2WW@135613|Chromatiales	1236|Gammaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	yagR	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_6648610_12	644107.SL1157_0407	2.243e-87	290.0	COG2080@1|root,COG2080@2|Bacteria,1MWA6@1224|Proteobacteria,2TS73@28211|Alphaproteobacteria,4NDS8@97050|Ruegeria	28211|Alphaproteobacteria	C	[2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Fer2_2
TLS2_k127_6648610_10	1469245.JFBG01000086_gene1610	5.71e-100	335.0	COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,1T26M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Xanthine dehydrogenase	xdhB	GO:0000166,GO:0003674,GO:0003824,GO:0004854,GO:0005488,GO:0006139,GO:0006144,GO:0006145,GO:0006150,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009114,GO:0009987,GO:0016491,GO:0016725,GO:0016726,GO:0019439,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046100,GO:0046113,GO:0046483,GO:0046700,GO:0048037,GO:0050660,GO:0050662,GO:0055086,GO:0055114,GO:0071704,GO:0071949,GO:0072521,GO:0072523,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575	1.17.1.4,1.3.99.8	ko:K13479,ko:K16878	ko00230,ko00365,ko01100,ko01120,map00230,map00365,map01100,map01120	M00546	R01768,R02103,R02987	RC00143,RC01856	ko00000,ko00001,ko00002,ko01000	-	-	iLF82_1304.LF82_2444,iNRG857_1313.NRG857_14070,iS_1188.S3069	CO_deh_flav_C,FAD_binding_5
TLS2_k127_6648610_5	670307.HYPDE_39543	2.135e-164	524.0	COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,2TQQ2@28211|Alphaproteobacteria,3N7GP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	MaoC like domain	mch	GO:0003674,GO:0003824,GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0045733,GO:0046395,GO:0071704,GO:0072329,GO:1901575	4.2.1.148	ko:K14449	ko00630,ko00660,ko00720,ko01120,ko01200,map00630,map00660,map00720,map01120,map01200	M00373,M00376,M00740	R05076	RC01984	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
TLS2_k127_6648610_4	582899.Hden_0640	9.303e-185	580.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TRFY@28211|Alphaproteobacteria,3N67X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_6662795_7	1267005.KB911255_gene2980	1.248e-60	211.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria,3N6GH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
TLS2_k127_6662795_5	335659.S23_59910	2.861e-65	235.0	COG0679@1|root,COG0679@2|Bacteria,1MY23@1224|Proteobacteria,2TR4M@28211|Alphaproteobacteria,3JQYF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
TLS2_k127_6662795_6	285535.JOEY01000006_gene8116	6.716e-64	232.0	COG2084@1|root,COG2084@2|Bacteria,2I9EJ@201174|Actinobacteria	201174|Actinobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_6662795_3	331869.BAL199_20065	3.26e-91	313.0	COG1712@1|root,COG1712@2|Bacteria,1MX8S@1224|Proteobacteria,2TV48@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate	nadX	-	1.4.1.21	ko:K06989	ko00760,ko01100,map00760,map01100	-	R07407,R07410	RC02566	ko00000,ko00001,ko01000	-	-	-	DUF108,NAD_binding_3
TLS2_k127_6662795_8	1121106.JQKB01000041_gene1572	2.082e-21	104.0	arCOG13343@1|root,32S6A@2|Bacteria,1N1WV@1224|Proteobacteria,2UEFY@28211|Alphaproteobacteria,2JY9J@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6662795_2	1038859.AXAU01000002_gene453	8.691e-109	358.0	COG0625@1|root,COG0625@2|Bacteria,1MW27@1224|Proteobacteria,2TUK1@28211|Alphaproteobacteria,3JTJI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	MA20_42385	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_C_2,GST_N,GST_N_3
TLS2_k127_6662795_0	1120792.JAFV01000001_gene2236	9.563e-220	689.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,36XFA@31993|Methylocystaceae	28211|Alphaproteobacteria	M	UDP binding domain	rkpK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS2_k127_6662795_1	1267005.KB911265_gene3594	1.244e-180	575.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2TR64@28211|Alphaproteobacteria,3N6CW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
TLS2_k127_6662795_4	717785.HYPMC_0547	4.775e-79	269.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2TRSH@28211|Alphaproteobacteria,3N6AB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_6683479_7	1206732.BAGD01000081_gene3303	7.396e-05	53.0	2EDMI@1|root,337HC@2|Bacteria,2GYPQ@201174|Actinobacteria,4G83Y@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6683479_2	331869.BAL199_12961	1.197e-118	393.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VEXI@28211|Alphaproteobacteria,4BS72@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
TLS2_k127_6683479_0	1198232.CYCME_1180	3.406e-180	573.0	COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,1RQZV@1236|Gammaproteobacteria,463RX@72273|Thiotrichales	1236|Gammaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	acd	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_6683479_4	1392838.AWNM01000019_gene3983	2.748e-94	321.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2VHK4@28216|Betaproteobacteria,3T5PS@506|Alcaligenaceae	28216|Betaproteobacteria	E	HMGL-like	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS2_k127_6683479_3	331869.BAL199_00952	1.313e-102	343.0	COG1024@1|root,COG1024@2|Bacteria,1MW41@1224|Proteobacteria,2TUR5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_6683479_5	1411123.JQNH01000001_gene2679	2.541e-56	207.0	COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,2TV81@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator GntR family	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS2_k127_6683479_6	883080.HMPREF9697_01441	2.977e-40	152.0	COG2721@1|root,COG2721@2|Bacteria,1MZBN@1224|Proteobacteria,2UC3F@28211|Alphaproteobacteria,3K07V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	SAF	-	-	4.4.1.24	ko:K16845	ko00270,map00270	-	R07633	RC01785	ko00000,ko00001,ko01000	-	-	-	SAF
TLS2_k127_6683479_1	1502851.FG93_02138	1.132e-151	489.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2TTDT@28211|Alphaproteobacteria,3JVQN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	garD	-	4.2.1.7,4.4.1.24	ko:K16846,ko:K16850	ko00040,ko00270,ko01100,map00040,map00270,map01100	M00631	R01540,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C
TLS2_k127_6686209_0	717785.HYPMC_4759	1.173e-319	986.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria,3N6CB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TLS2_k127_6686209_4	1267005.KB911262_gene3344	8.742e-37	142.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2UBRZ@28211|Alphaproteobacteria,3N735@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
TLS2_k127_6686209_3	1267005.KB911256_gene1446	9.43e-73	253.0	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,2U81X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Staphylococcal nuclease homologues	-	-	-	-	-	-	-	-	-	-	-	-	SNase
TLS2_k127_6686209_5	526227.Mesil_2826	0.000284	51.0	COG0477@1|root,COG2814@2|Bacteria,1WJ8Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EGP	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_4
TLS2_k127_6686209_2	1380394.JADL01000008_gene3447	6.652e-117	389.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TUWV@28211|Alphaproteobacteria,2JQWC@204441|Rhodospirillales	204441|Rhodospirillales	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_6686209_1	1122929.KB908215_gene1027	8.748e-129	426.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2TT0D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Threonine synthase	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0006082,GO:0006520,GO:0006566,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016311,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
TLS2_k127_67687_2	582899.Hden_2652	2.883e-157	503.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,3N6A5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TLS2_k127_67687_5	258594.RPA4314	2.388e-75	259.0	COG0625@1|root,COG0625@2|Bacteria,1REDI@1224|Proteobacteria,2TUGP@28211|Alphaproteobacteria,3JTRR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	MA20_05155	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
TLS2_k127_67687_0	670307.HYPDE_36878	1.484e-256	796.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3N6EF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
TLS2_k127_67687_7	717785.HYPMC_4793	3.156e-59	209.0	COG3760@1|root,COG3760@2|Bacteria,1RDIG@1224|Proteobacteria,2U87T@28211|Alphaproteobacteria,3N929@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	YbaK prolyl-tRNA synthetase associated	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
TLS2_k127_67687_4	1267005.KB911257_gene990	9.149e-118	385.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,3N6CR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Tetratricopeptide repeat	trxA2	-	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
TLS2_k127_67687_6	717785.HYPMC_4791	2.629e-68	239.0	COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,2TQZ4@28211|Alphaproteobacteria,3N6UF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	peptidase S16	lonD	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
TLS2_k127_67687_8	187303.BN69_0912	1.13e-19	91.0	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2UF4N@28211|Alphaproteobacteria,36YSR@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Trm112p-like protein	MA20_24965	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
TLS2_k127_67687_1	1205680.CAKO01000037_gene1210	7.455e-234	736.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JR7C@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the aldehyde dehydrogenase family	betB	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_67687_3	1168059.KB899087_gene2785	1.268e-127	412.0	COG1028@1|root,COG1028@2|Bacteria,1MVT2@1224|Proteobacteria,2TQKU@28211|Alphaproteobacteria,3EXWC@335928|Xanthobacteraceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fixR	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_6777519_14	1380394.JADL01000009_gene3164	1.21e-16	88.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2JPPV@204441|Rhodospirillales	204441|Rhodospirillales	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_6777519_12	414684.RC1_1595	8.002e-46	174.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2U79T@28211|Alphaproteobacteria,2JSSB@204441|Rhodospirillales	204441|Rhodospirillales	S	Phosphoglycolate phosphatase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_6777519_1	582899.Hden_1623	3.208e-185	586.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2TSKQ@28211|Alphaproteobacteria,3N68Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
TLS2_k127_6777519_8	1411123.JQNH01000001_gene1779	2.291e-80	285.0	COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria,2TRJZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Family of unknown function (DUF1028)	MA20_16755	-	-	-	-	-	-	-	-	-	-	-	DUF1028
TLS2_k127_6777519_7	716928.AJQT01000017_gene4636	5.446e-85	286.0	COG0625@1|root,COG0625@2|Bacteria,1MWUG@1224|Proteobacteria,2TTZ6@28211|Alphaproteobacteria,4B7MR@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase	gstB	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_3,GST_N
TLS2_k127_6777519_0	1211115.ALIQ01000016_gene4587	4.735e-250	777.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,3NAC8@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_6777519_3	1267005.KB911265_gene3606	1.537e-135	435.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2TR43@28211|Alphaproteobacteria,3N68C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	chvI	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K14981	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_6777519_2	1267005.KB911265_gene3605	1.246e-162	535.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,2TS69@28211|Alphaproteobacteria,3N6JH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Signal transduction histidine kinase	chvG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K14980	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
TLS2_k127_6777519_10	861299.J421_4385	8.418e-73	261.0	COG0477@1|root,COG2814@2|Bacteria,1ZSUR@142182|Gemmatimonadetes	2|Bacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_6777519_5	227377.CBU_0720	1.059e-100	340.0	COG0010@1|root,COG0010@2|Bacteria,1NCRN@1224|Proteobacteria,1RNKI@1236|Gammaproteobacteria,1JDKG@118969|Legionellales	118969|Legionellales	F	Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide	hutG	-	3.5.3.11,3.5.3.8	ko:K01479,ko:K01480	ko00330,ko00340,ko01100,map00330,map00340,map01100	M00045,M00133	R01157,R02285	RC00024,RC00221,RC00329,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS2_k127_6777519_11	1121861.KB899950_gene2349	1.152e-59	216.0	COG1028@1|root,COG1028@2|Bacteria,1R4UB@1224|Proteobacteria,2TR75@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	short-chain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_15,adh_short_C2
TLS2_k127_6777519_4	648757.Rvan_0170	8.743e-127	428.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,2TR9F@28211|Alphaproteobacteria,3N6CF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family group 2	-	-	-	ko:K20327	ko02024,map02024	-	-	-	ko00000,ko00001,ko01003	-	GT2	-	Glyco_tranf_2_3,Glyco_trans_2_3,T2SSE_N
TLS2_k127_6777519_6	582899.Hden_2286	4.692e-90	306.0	COG0834@1|root,COG0834@2|Bacteria,1MXIA@1224|Proteobacteria,2VETI@28211|Alphaproteobacteria,3N6XA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	MA20_22110	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
TLS2_k127_6777519_13	670307.HYPDE_36833	3.965e-41	160.0	COG0457@1|root,COG0457@2|Bacteria,1N0DE@1224|Proteobacteria,2UCGA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	MA20_05980	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_6,TPR_8
TLS2_k127_6777519_9	1267005.KB911258_gene415	1.026e-76	263.0	28I3D@1|root,2Z876@2|Bacteria,1P0DR@1224|Proteobacteria,2TTG2@28211|Alphaproteobacteria,3N757@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PilZ domain	MA20_31715	-	-	-	-	-	-	-	-	-	-	-	PilZ
TLS2_k127_678189_9	1125973.JNLC01000013_gene4120	1.802e-07	53.0	COG0071@1|root,COG0071@2|Bacteria,1RH2X@1224|Proteobacteria,2U96D@28211|Alphaproteobacteria,3JYEA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	ibpA	-	-	ko:K04080	-	-	-	-	ko00000,ko03110	-	-	-	HSP20
TLS2_k127_678189_0	1267005.KB911256_gene2055	5.996e-280	869.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2TRHX@28211|Alphaproteobacteria,3N6H4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
TLS2_k127_678189_1	1267005.KB911264_gene3151	1.815e-256	800.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,2TRP5@28211|Alphaproteobacteria,3N6KB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
TLS2_k127_678189_4	331869.BAL199_06164	1.526e-145	477.0	COG0477@1|root,COG2814@2|Bacteria,1MUDA@1224|Proteobacteria,2TS0P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_678189_8	319003.Bra1253DRAFT_03847	4.075e-44	168.0	COG4297@1|root,COG4297@2|Bacteria,1RB1W@1224|Proteobacteria,2U14J@28211|Alphaproteobacteria,3JY1Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	protein containing double-stranded beta helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1,Cupin_2,Cupin_6
TLS2_k127_678189_2	1267005.KB911255_gene2430	6.426e-167	539.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2TQPN@28211|Alphaproteobacteria,3N6BE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_678189_5	1267005.KB911255_gene2429	3.507e-141	456.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2TS12@28211|Alphaproteobacteria,3N6K5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Prephenate dehydrogenase	tyrC	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.3.1.12,1.3.1.43	ko:K00210,ko:K00220,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025,M00040	R00732,R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
TLS2_k127_678189_3	1267005.KB911260_gene3415	7.536e-166	535.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2TR3S@28211|Alphaproteobacteria,3N6T6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	MU	Outer membrane efflux protein	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
TLS2_k127_678189_7	1267005.KB911256_gene1450	1.492e-73	256.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2U5P0@28211|Alphaproteobacteria,3N6UA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
TLS2_k127_678189_6	1267005.KB911256_gene1451	1.927e-105	347.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2TT6Q@28211|Alphaproteobacteria,3N6TR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
TLS2_k127_6803000_12	1041159.AZUW01000009_gene4725	3.529e-11	66.0	COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,2U8S1@28211|Alphaproteobacteria,4B9XS@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
TLS2_k127_6803000_4	717785.HYPMC_3272	9.098e-95	315.0	COG2135@1|root,COG2135@2|Bacteria,1NXVH@1224|Proteobacteria,2UT6M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
TLS2_k127_6803000_10	319003.Bra1253DRAFT_00003	2.011e-19	89.0	2B1WH@1|root,30C4Q@2|Bacteria,1R3E9@1224|Proteobacteria,2U7UN@28211|Alphaproteobacteria,3K27G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
TLS2_k127_6803000_9	224911.27354821	1.125e-19	91.0	2B1WH@1|root,30C4Q@2|Bacteria,1R3E9@1224|Proteobacteria,2U7UN@28211|Alphaproteobacteria,3K27G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
TLS2_k127_6803000_13	716928.AJQT01000028_gene2290	2.536e-09	63.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HWE_HK,PAS_3,PAS_4,Response_reg
TLS2_k127_6803000_11	743836.AYNA01000028_gene2411	3.655e-13	72.0	2DR1J@1|root,339SA@2|Bacteria,1NI5R@1224|Proteobacteria,2UM1E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidase propeptide and YPEB domain	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_2
TLS2_k127_6803000_6	1123354.AUDR01000014_gene1084	3.228e-30	134.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2W9BF@28216|Betaproteobacteria,1KT6Y@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
TLS2_k127_6803000_0	1510531.JQJJ01000008_gene3411	1.057e-186	590.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,3JR5R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	livK	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_6803000_7	663610.JQKO01000003_gene1305	1.804e-26	113.0	2C07J@1|root,32SWS@2|Bacteria,1N0NW@1224|Proteobacteria,2UCVR@28211|Alphaproteobacteria,3NBR9@45404|Beijerinckiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6803000_3	438753.AZC_2945	1.287e-117	383.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,3EYUN@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_6803000_2	1125973.JNLC01000018_gene2218	1.373e-130	433.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,3JS3Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ABC transporter	braF	GO:0003333,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015808,GO:0015818,GO:0015829,GO:0015849,GO:0015893,GO:0032328,GO:0034220,GO:0042221,GO:0042493,GO:0042940,GO:0042941,GO:0043090,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903805,GO:1903806,GO:1903825,GO:1905039	3.5.4.44	ko:K01995,ko:K15783	ko00260,ko01100,ko02010,ko02024,map00260,map01100,map02010,map02024	M00237	R09800	RC02661	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_6803000_1	1211115.ALIQ01000095_gene281	5.665e-173	571.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,3NASJ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	Domain of unknown function (DUF3382)	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2,DUF3382
TLS2_k127_6803000_5	670307.HYPDE_33453	4.959e-33	128.0	COG3369@1|root,COG3369@2|Bacteria,1N6QZ@1224|Proteobacteria,2UGR1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Iron-binding zinc finger CDGSH type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
TLS2_k127_6803000_8	160488.PP_4463	5.337e-22	96.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1YW35@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
TLS2_k127_6842645_14	1510531.JQJJ01000009_gene1108	1.498e-14	77.0	COG0747@1|root,COG0747@2|Bacteria,1R63Z@1224|Proteobacteria,2U2AU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
TLS2_k127_6842645_11	1123229.AUBC01000047_gene3803	3.932e-45	172.0	COG4126@1|root,COG4126@2|Bacteria,1MVNB@1224|Proteobacteria,2U28G@28211|Alphaproteobacteria,3JVNQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Asp/Glu/Hydantoin racemase	MA20_32210	-	5.1.99.3	ko:K16841	ko00230,ko01120,map00230,map01120	-	R03925	RC01027	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
TLS2_k127_6842645_4	1123237.Salmuc_03678	2.233e-120	407.0	COG2234@1|root,COG2234@2|Bacteria,1PF4S@1224|Proteobacteria,2U3SU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_6842645_12	1218084.BBJK01000072_gene5044	2.289e-41	162.0	COG1802@1|root,COG1802@2|Bacteria,1MY8X@1224|Proteobacteria,2VRYQ@28216|Betaproteobacteria,1K2Z5@119060|Burkholderiaceae	28216|Betaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_6842645_10	870187.Thini_3083	1.865e-53	201.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1RPXT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	yafK	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS2_k127_6842645_0	331869.BAL199_12501	7.094e-261	821.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,4BRAB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EQ	N-methylhydantoinase A acetone carboxylase, beta subunit	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
TLS2_k127_6842645_1	331869.BAL199_12506	8.543e-235	743.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,4BRM1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
TLS2_k127_6842645_6	391735.Veis_4512	1.46e-72	253.0	COG1028@1|root,COG1028@2|Bacteria,1R5U2@1224|Proteobacteria,2VUDZ@28216|Betaproteobacteria,4AGIB@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	short-chain dehydrogenase reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_6842645_3	1122214.AQWH01000005_gene1201	5.68e-200	639.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_6842645_9	1122214.AQWH01000005_gene1195	1.179e-68	244.0	COG0451@1|root,COG0451@2|Bacteria,1R455@1224|Proteobacteria,2U1H6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_6842645_5	1121861.KB899919_gene2749	2.812e-76	267.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JSUV@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
TLS2_k127_6842645_8	1121861.KB899919_gene2749	7.839e-69	245.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JSUV@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
TLS2_k127_6842645_13	420324.KI912026_gene4764	1.396e-14	79.0	2DMY4@1|root,32UCB@2|Bacteria,1N6NJ@1224|Proteobacteria,2UES2@28211|Alphaproteobacteria,1JYU1@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
TLS2_k127_6842645_2	977880.RALTA_B1773	3.295e-208	662.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1K17A@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	tctA4	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
TLS2_k127_6842645_7	1244869.H261_01237	1.179e-69	246.0	COG1414@1|root,COG1414@2|Bacteria,1MXRJ@1224|Proteobacteria,2TSJ7@28211|Alphaproteobacteria,2JPDQ@204441|Rhodospirillales	204441|Rhodospirillales	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS2_k127_6848325_23	670307.HYPDE_39628	6.372e-34	134.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria,3N6G9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	FtsX-like permease family	MA20_43810	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_6848325_15	1267005.KB911257_gene913	9.031e-91	307.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2TRSF@28211|Alphaproteobacteria,3N6P8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the BI1 family	ybhL	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
TLS2_k127_6848325_17	1207063.P24_14060	1.594e-62	224.0	COG1247@1|root,COG1247@2|Bacteria,1RDHN@1224|Proteobacteria,2U98I@28211|Alphaproteobacteria,2JSWH@204441|Rhodospirillales	204441|Rhodospirillales	M	COG1247 Sortase and related acyltransferases	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
TLS2_k127_6848325_10	1411123.JQNH01000001_gene1673	6.138e-126	410.0	COG0265@1|root,COG0265@2|Bacteria,1MURF@1224|Proteobacteria,2TUVW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	PDZ DHR GLGF domain protein	MA20_20705	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_6848325_5	717785.HYPMC_2537	1.629e-185	589.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria,3N67Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Transporter associated domain	tlyC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_6848325_16	179408.Osc7112_4187	2.069e-76	269.0	COG1735@1|root,COG1735@2|Bacteria,1G4D4@1117|Cyanobacteria,1H9TU@1150|Oscillatoriales	1117|Cyanobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6848325_2	1304878.AUGD01000006_gene6595	3.192e-214	669.0	COG2358@1|root,COG2358@2|Bacteria,1R3ZR@1224|Proteobacteria,2TSND@28211|Alphaproteobacteria,3JV59@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
TLS2_k127_6848325_1	1304878.AUGD01000006_gene6594	0.0	1114.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,3JT1C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS2_k127_6848325_3	717785.HYPMC_0001	1.127e-192	615.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria,3N6HS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
TLS2_k127_6848325_20	670307.HYPDE_41848	4.639e-55	196.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2UBVU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0607 Rhodanese-related sulfurtransferase	pspE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_6848325_24	395965.Msil_3922	5.702e-22	99.0	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2UC42@28211|Alphaproteobacteria,3NBGH@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	rRNA binding	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
TLS2_k127_6848325_14	1267005.KB911256_gene1848	1.34e-91	327.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2TSBE@28211|Alphaproteobacteria,3N6MP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006807,GO:0006810,GO:0008104,GO:0008150,GO:0008152,GO:0015031,GO:0015399,GO:0015405,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022804,GO:0022857,GO:0031224,GO:0032991,GO:0033036,GO:0042157,GO:0042160,GO:0042623,GO:0042626,GO:0042886,GO:0042953,GO:0043170,GO:0043190,GO:0043492,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901564,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
TLS2_k127_6848325_4	1267005.KB911256_gene1847	7.737e-187	593.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria,3N6BX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
TLS2_k127_6848325_18	670307.HYPDE_28663	1.22e-61	221.0	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2U9WD@28211|Alphaproteobacteria,3N74J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Phosphoglycerate mutase family	gpmB	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TLS2_k127_6848325_9	631454.N177_2063	2.313e-141	466.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria,1JNS3@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
TLS2_k127_6848325_6	441620.Mpop_5189	1.811e-165	531.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,1JTCM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_6848325_13	1961.JOAK01000009_gene6429	1.999e-94	321.0	COG1024@1|root,COG1024@2|Bacteria,2GMET@201174|Actinobacteria	201174|Actinobacteria	I	enoyl-CoA hydratase	echA9	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_2
TLS2_k127_6848325_12	1380394.JADL01000001_gene2544	1.456e-94	328.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TUKZ@28211|Alphaproteobacteria,2JZ9Y@204441|Rhodospirillales	204441|Rhodospirillales	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_6848325_19	1267005.KB911255_gene2498	9.997e-59	210.0	COG0457@1|root,COG0457@2|Bacteria	1267005.KB911255_gene2498|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6848325_22	1207063.P24_07241	3.646e-35	139.0	2CIU6@1|root,32S8H@2|Bacteria,1MZTN@1224|Proteobacteria,2UCA8@28211|Alphaproteobacteria,2JUA3@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6848325_8	398527.Bphyt_0192	4.58e-155	501.0	COG3185@1|root,COG3185@2|Bacteria,1MVR0@1224|Proteobacteria,2VJHM@28216|Betaproteobacteria,1JZQQ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Acyclic terpene utilisation family protein AtuA	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
TLS2_k127_6848325_7	1207063.P24_00345	1.767e-159	512.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TU1G@28211|Alphaproteobacteria,2JPQP@204441|Rhodospirillales	204441|Rhodospirillales	C	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_6848325_21	766499.C357_03805	1.149e-40	156.0	COG2050@1|root,COG2050@2|Bacteria,1RGVD@1224|Proteobacteria,2U9MH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	protein possibly involved in aromatic compounds catabolism	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_6848325_11	1123072.AUDH01000001_gene2811	1.381e-103	342.0	COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2TT2W@28211|Alphaproteobacteria,2JS3C@204441|Rhodospirillales	204441|Rhodospirillales	G	Belongs to the HpcH HpaI aldolase family	-	-	2.7.7.38,4.1.2.52	ko:K00979,ko:K02510	ko00350,ko00540,ko01100,ko01120,map00350,map00540,map01100,map01120	M00063	R01645,R01647,R03351,R11396	RC00152,RC00307,RC00572,RC00574,RC00910,RC03057	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	HpcH_HpaI
TLS2_k127_6848325_0	1267005.KB911260_gene3531	0.0	1286.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria,3N6JX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS2_k127_6895061_9	717785.HYPMC_1651	2.157e-40	153.0	2C7TH@1|root,32RJS@2|Bacteria,1MZK8@1224|Proteobacteria,2UC2R@28211|Alphaproteobacteria,3N7B2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ETC complex I subunit conserved region	MA20_30235	-	1.6.5.3	ko:K00329	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	ETC_C1_NDUFA4
TLS2_k127_6895061_7	1267005.KB911255_gene3012	2.573e-54	203.0	COG4111@1|root,COG4111@2|Bacteria,1MXHA@1224|Proteobacteria,2TQQU@28211|Alphaproteobacteria,3N7IW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	belongs to the nudix hydrolase family	MA20_42130	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6895061_0	1267005.KB911255_gene3018	0.0	1257.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,3N6KF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	pyruvate phosphate dikinase	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS2_k127_6895061_1	717785.HYPMC_2979	6.645e-217	682.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2TQY4@28211|Alphaproteobacteria,3N67A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Peptidase dimerisation domain	MA20_15735	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_6895061_14	243231.GSU1506	0.0004635	51.0	COG4122@1|root,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21,SAM_MT
TLS2_k127_6895061_8	582899.Hden_2778	1.032e-40	159.0	COG3637@1|root,COG3637@2|Bacteria,1NJWW@1224|Proteobacteria,2UD8G@28211|Alphaproteobacteria,3N8SQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Outer membrane protein beta-barrel domain	-	-	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	OMP_b-brl
TLS2_k127_6895061_2	1205680.CAKO01000010_gene3955	8.69e-215	671.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TT8C@28211|Alphaproteobacteria,2JW97@204441|Rhodospirillales	204441|Rhodospirillales	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_6895061_3	1446473.JHWH01000008_gene140	5.876e-132	434.0	COG1929@1|root,COG1929@2|Bacteria,1MVG9@1224|Proteobacteria,2U21E@28211|Alphaproteobacteria,2PWC6@265|Paracoccus	28211|Alphaproteobacteria	G	Glycerate kinase family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
TLS2_k127_6895061_12	1123229.AUBC01000015_gene4742	4.953e-16	91.0	COG5662@1|root,COG5662@2|Bacteria,1N8DF@1224|Proteobacteria,2UGV4@28211|Alphaproteobacteria,3K5KY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6895061_10	1380394.JADL01000003_gene4965	7.351e-39	151.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2UBS6@28211|Alphaproteobacteria,2JTR9@204441|Rhodospirillales	204441|Rhodospirillales	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6895061_6	1569209.BBPH01000264_gene461	2.374e-64	237.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2TT0E@28211|Alphaproteobacteria,2PWJS@265|Paracoccus	28211|Alphaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS2_k127_6895061_4	1144305.PMI02_01129	1.068e-122	412.0	COG3920@1|root,COG3920@2|Bacteria,1MXWD@1224|Proteobacteria,2TUVS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,HisKA_2,PAS_4,PAS_8,PAS_9
TLS2_k127_6895061_5	107635.AZUO01000003_gene4148	5.905e-74	249.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria,371C2@31993|Methylocystaceae	28211|Alphaproteobacteria	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
TLS2_k127_6927367_5	1510531.JQJJ01000008_gene3841	4.652e-10	61.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria,3JTIH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Iron-containing alcohol dehydrogenase	gbd	-	1.1.1.1,1.1.1.61	ko:K00043,ko:K13954	ko00010,ko00071,ko00350,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00071,map00350,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01200,map01220	-	R00623,R00754,R01644,R04880,R05233,R05234,R06917,R06927	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
TLS2_k127_6927367_1	1380394.JADL01000010_gene4332	9.172e-187	591.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2TU3A@28211|Alphaproteobacteria,2JSQM@204441|Rhodospirillales	204441|Rhodospirillales	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_6927367_4	331869.BAL199_18701	6.486e-19	87.0	2E3X5@1|root,32YUB@2|Bacteria,1N766@1224|Proteobacteria,2UFVD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknwon function (DUF3008)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3008
TLS2_k127_6927367_3	1509405.GV67_19965	2.99e-56	209.0	COG2032@1|root,COG2032@2|Bacteria,1RGV4@1224|Proteobacteria,2UC22@28211|Alphaproteobacteria,4BNJ0@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodC	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
TLS2_k127_6927367_6	999419.HMPREF1077_01219	3.857e-09	67.0	COG0697@1|root,COG0697@2|Bacteria,4NK8U@976|Bacteroidetes,2FNMF@200643|Bacteroidia,22XPM@171551|Porphyromonadaceae	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_6927367_0	1429916.X566_16105	8.672e-290	898.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQU2@28211|Alphaproteobacteria,3JUAT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, middle domain	MA20_19255	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
TLS2_k127_6927367_2	670307.HYPDE_41553	9.703e-58	204.0	COG1396@1|root,COG1396@2|Bacteria,1RDBW@1224|Proteobacteria,2U7CY@28211|Alphaproteobacteria,3N8NE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Helix-turn-helix XRE-family like proteins	MA20_23890	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS2_k127_6959036_6	717785.HYPMC_0679	6.733e-45	167.0	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,2U1SX@28211|Alphaproteobacteria,3N7RR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	ABC-type uncharacterized transport system	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_transp_aux
TLS2_k127_6959036_5	670307.HYPDE_37168	2.769e-49	190.0	2DM5E@1|root,31SVN@2|Bacteria,1MYKR@1224|Proteobacteria,2U9KT@28211|Alphaproteobacteria,3N8ZR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
TLS2_k127_6959036_4	272630.MexAM1_META1p3073	5.856e-61	217.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2U6ZC@28211|Alphaproteobacteria,1JUJS@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_6959036_7	1380355.JNIJ01000010_gene1502	4.176e-42	162.0	2EIES@1|root,33C66@2|Bacteria,1NK2A@1224|Proteobacteria,2UMNM@28211|Alphaproteobacteria,3K45Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6959036_8	1380355.JNIJ01000010_gene1501	1.099e-40	153.0	2AJXY@1|root,31AM3@2|Bacteria,1NWTC@1224|Proteobacteria,2US0F@28211|Alphaproteobacteria,3K41X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6959036_10	1380355.JNIJ01000010_gene1500	5.717e-28	119.0	2EIVU@1|root,31B6W@2|Bacteria,1Q6YQ@1224|Proteobacteria,2VD2H@28211|Alphaproteobacteria,3K4DH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6959036_0	1038859.AXAU01000005_gene5108	0.0	1131.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria,3JT27@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sodium:solute symporter family	yjcG	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
TLS2_k127_6959036_9	1380355.JNIJ01000010_gene1498	2.959e-35	138.0	COG4327@1|root,COG4327@2|Bacteria,1Q1GP@1224|Proteobacteria,2V981@28211|Alphaproteobacteria,3K4Z0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4212)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4212
TLS2_k127_6959036_3	1038859.AXAU01000005_gene5110	6.188e-66	231.0	2EFIM@1|root,339B1@2|Bacteria,1NMH3@1224|Proteobacteria,2UGEE@28211|Alphaproteobacteria,3K3PE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6959036_1	1502851.FG93_05022	7.56e-163	522.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2TQTI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	TIGRFAM amidase, hydantoinase carbamoylase family	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_6959036_2	1205680.CAKO01000029_gene5215	3.314e-123	399.0	COG3473@1|root,COG3473@2|Bacteria	2|Bacteria	Q	Maleate cis-trans isomerase	-	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
TLS2_k127_6972209_0	717785.HYPMC_2877	0.0	1515.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,3N673@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA polymerase	dnaE	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS2_k127_6972209_2	1205680.CAKO01000037_gene1303	4.333e-117	390.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JZJF@204441|Rhodospirillales	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
TLS2_k127_6972209_1	1205680.CAKO01000037_gene1302	2.228e-218	687.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,2JPTU@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
TLS2_k127_6972209_6	1205680.CAKO01000037_gene1301	1.963e-16	86.0	2CQ1K@1|root,32SKA@2|Bacteria	2|Bacteria	S	membrane	MA20_15810	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
TLS2_k127_6972209_3	263358.VAB18032_20485	2.354e-103	344.0	COG2518@1|root,COG2518@2|Bacteria,2I5PV@201174|Actinobacteria,4DMPR@85008|Micromonosporales	201174|Actinobacteria	O	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
TLS2_k127_6972209_5	1122604.JONR01000010_gene3877	3.658e-42	159.0	COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,1S4HQ@1236|Gammaproteobacteria,1X72V@135614|Xanthomonadales	135614|Xanthomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS2_k127_6972209_4	331869.BAL199_17668	3.253e-96	318.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2U0KX@28211|Alphaproteobacteria,4BT90@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	COG0402 Cytosine deaminase and related metal-dependent hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_7083306_13	1267005.KB911258_gene627	1.191e-101	336.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria,3N6CE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TLS2_k127_7083306_0	1267005.KB911256_gene2011	0.0	1386.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,3N69V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
TLS2_k127_7083306_21	717785.HYPMC_1013	2.381e-41	167.0	COG5373@1|root,COG5373@2|Bacteria,1QXW9@1224|Proteobacteria	1224|Proteobacteria	S	membrane	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	-
TLS2_k127_7083306_19	1267005.KB911259_gene3877	2.124e-51	186.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2UA46@28211|Alphaproteobacteria,3N75U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Biopolymer transport protein ExbD TolR	tolR	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS2_k127_7083306_11	670307.HYPDE_35723	6.849e-112	366.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2TQXQ@28211|Alphaproteobacteria,3N6M5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	MotA/TolQ/ExbB proton channel family	tolQ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
TLS2_k127_7083306_18	582899.Hden_2433	1.748e-53	193.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2UBYM@28211|Alphaproteobacteria,3N7AJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Thioesterase-like superfamily	ybgC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
TLS2_k127_7083306_12	460265.Mnod_5511	2.094e-110	364.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,2TVHN@28211|Alphaproteobacteria,1JRS7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
TLS2_k127_7083306_3	582899.Hden_2435	7.888e-182	577.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2TQNG@28211|Alphaproteobacteria,3N6BJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
TLS2_k127_7083306_6	1267005.KB911256_gene1542	9.9e-149	477.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2TR53@28211|Alphaproteobacteria,3N6GW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
TLS2_k127_7083306_4	582899.Hden_1292	4.338e-172	544.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2TR60@28211|Alphaproteobacteria,3N6J7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
TLS2_k127_7083306_20	1267005.KB911256_gene1544	2.689e-43	160.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2UCDG@28211|Alphaproteobacteria,3N75G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_7083306_24	224911.27353283	5.784e-35	139.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,2U9A5@28211|Alphaproteobacteria,3JQMB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, mercury resistance	merR	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_7083306_27	670307.HYPDE_29498	1.225e-16	89.0	COG2091@1|root,COG2091@2|Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	sfp	-	2.7.8.7	ko:K00997,ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_7083306_16	1007105.PT7_2081	9.503e-74	257.0	COG0778@1|root,COG0778@2|Bacteria,1PG8V@1224|Proteobacteria,2VKIZ@28216|Betaproteobacteria,3T8T1@506|Alcaligenaceae	28216|Betaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_7083306_25	1121106.JQKB01000006_gene1311	1.316e-28	117.0	2E8MD@1|root,332YV@2|Bacteria,1MYV4@1224|Proteobacteria,2UFX9@28211|Alphaproteobacteria,2JTWR@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7083306_30	1429916.X566_03460	6.417e-12	70.0	COG0454@1|root,COG0454@2|Bacteria,1QUQU@1224|Proteobacteria,2TXUA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
TLS2_k127_7083306_28	1429916.X566_03460	1.493e-13	74.0	COG0454@1|root,COG0454@2|Bacteria,1QUQU@1224|Proteobacteria,2TXUA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
TLS2_k127_7083306_15	582899.Hden_1990	4.324e-83	283.0	COG1280@1|root,COG1280@2|Bacteria,1N227@1224|Proteobacteria,2UCZW@28211|Alphaproteobacteria,3N8KX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Lysine exporter protein LysE YggA	-	-	-	-	-	-	-	-	-	-	-	-	LysE
TLS2_k127_7083306_22	670307.HYPDE_28578	7.945e-39	153.0	COG5451@1|root,COG5451@2|Bacteria,1MYIV@1224|Proteobacteria,2UGCX@28211|Alphaproteobacteria,3N7DK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2385)	MA20_42075	-	-	-	-	-	-	-	-	-	-	-	DUF2385
TLS2_k127_7083306_10	991905.SL003B_1105	1.191e-115	380.0	COG3485@1|root,COG3485@2|Bacteria,1MX7W@1224|Proteobacteria,2TT8T@28211|Alphaproteobacteria,4BRGY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Catechol dioxygenase N terminus	-	-	1.13.11.1	ko:K03381	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	M00568	R00817,R04258,R05299,R08114,R08115,R09134	RC00388,RC00535,RC01366	ko00000,ko00001,ko00002,ko01000	-	-	-	Dioxygenase_C,Dioxygenase_N
TLS2_k127_7083306_9	670307.HYPDE_41648	1.837e-124	405.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria,3N6RU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	UBA THIF-type NAD FAD binding protein	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
TLS2_k127_7083306_7	1121861.KB899911_gene1193	4.446e-129	422.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRW0@28211|Alphaproteobacteria,2JRVT@204441|Rhodospirillales	204441|Rhodospirillales	C	Dehydrogenase E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
TLS2_k127_7083306_5	1121861.KB899911_gene1192	1.94e-153	496.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,2JR4B@204441|Rhodospirillales	204441|Rhodospirillales	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_7083306_14	1205680.CAKO01000002_gene3015	7.694e-89	299.0	COG1028@1|root,COG1028@2|Bacteria,1R3U8@1224|Proteobacteria,2U1SI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_7083306_2	1267005.KB911258_gene620	1.032e-208	659.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,3N65W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS2_k127_7083306_1	1187851.A33M_2302	1.128e-222	697.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,3FCPZ@34008|Rhodovulum	28211|Alphaproteobacteria	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS2_k127_7083306_8	1267005.KB911258_gene618	1.92e-127	423.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2TSEA@28211|Alphaproteobacteria,3N6R0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
TLS2_k127_7083306_17	648757.Rvan_2007	3.915e-63	235.0	COG3494@1|root,COG3494@2|Bacteria,1MWTH@1224|Proteobacteria,2U4AB@28211|Alphaproteobacteria,3N7B6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1009)	cdsA2	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
TLS2_k127_7083306_31	1120983.KB894571_gene2159	1.012e-06	54.0	2EHVQ@1|root,33BM8@2|Bacteria,1NN36@1224|Proteobacteria,2UK93@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7083306_29	1267005.KB911260_gene3450	2.277e-13	73.0	COG5509@1|root,COG5509@2|Bacteria,1NG8P@1224|Proteobacteria,2UJB2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1192)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1192
TLS2_k127_7087840_3	1217720.ALOX01000071_gene623	1.285e-63	228.0	COG4359@1|root,COG4359@2|Bacteria,1REUD@1224|Proteobacteria,2U9HY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
TLS2_k127_7087840_0	1510531.JQJJ01000009_gene1039	4.793e-261	809.0	COG0160@1|root,COG0160@2|Bacteria,1QTZ3@1224|Proteobacteria,2TVZK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
TLS2_k127_7087840_2	1267005.KB911265_gene3638	8.281e-90	314.0	COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,2U5K8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Hydrolase_4
TLS2_k127_7087840_1	1267005.KB911262_gene3318	1.651e-91	310.0	COG4531@1|root,COG4531@2|Bacteria,1QTTI@1224|Proteobacteria,2TVXP@28211|Alphaproteobacteria,3N6GS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	periplasmic solute binding protein	znuA	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
TLS2_k127_7091575_3	504832.OCAR_5855	1.014e-149	482.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2TS3F@28211|Alphaproteobacteria,3JRDV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
TLS2_k127_7091575_1	1411123.JQNH01000001_gene348	7.622e-189	601.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TR2Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG0277 FAD FMN-containing dehydrogenases	dld	GO:0003674,GO:0003824,GO:0004457,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008720,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046034,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.1.1.303,1.1.1.4,1.1.2.4	ko:K00004,ko:K00102	ko00620,ko00650,map00620,map00650	-	R00197,R02855,R02946,R10504	RC00044,RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_7091575_2	717785.HYPMC_4784	2.217e-179	576.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2TS44@28211|Alphaproteobacteria,3N6AR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TLS2_k127_7091575_0	1267005.KB911257_gene985	0.0	1163.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,3N6A4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
TLS2_k127_7091575_4	1408444.JHYC01000031_gene1915	1.659e-20	93.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1JC56@118969|Legionellales	118969|Legionellales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
TLS2_k127_7106953_7	1288298.rosmuc_01223	1.779e-47	175.0	COG0509@1|root,COG0509@2|Bacteria,1RKRS@1224|Proteobacteria,2UAPN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glycine cleavage H-protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
TLS2_k127_7106953_8	1288298.rosmuc_02795	7.852e-41	155.0	2E6B9@1|root,330Z3@2|Bacteria,1N9PF@1224|Proteobacteria,2UFEJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7106953_0	1125973.JNLC01000015_gene3148	1.886e-237	764.0	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,2TUFY@28211|Alphaproteobacteria,3JXSR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
TLS2_k127_7106953_6	1131814.JAFO01000001_gene990	5.934e-67	237.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,3EZIN@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
TLS2_k127_7106953_2	991905.SL003B_1283	1.301e-174	560.0	COG1921@1|root,COG1921@2|Bacteria,1MW8F@1224|Proteobacteria,2TSR8@28211|Alphaproteobacteria,4BR1T@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	L-seryl-tRNA selenium transferase	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	SelA
TLS2_k127_7106953_4	189753.AXAS01000086_gene6880	5.758e-93	314.0	COG3058@1|root,COG3058@2|Bacteria,1NK06@1224|Proteobacteria,2U11R@28211|Alphaproteobacteria,3JXFA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Necessary for formate dehydrogenase activity	fdhE	-	-	ko:K02380	-	-	-	-	ko00000	-	-	-	FdhE
TLS2_k127_7106953_5	1288298.rosmuc_02788	9.089e-84	284.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2TT30@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	formate dehydrogenase	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
TLS2_k127_7106953_3	991905.SL003B_1280	7.484e-152	484.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2TTE2@28211|Alphaproteobacteria,4BPV1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	fdxH	-	-	ko:K00124,ko:K21308	ko00630,ko00680,ko00920,ko01100,ko01120,ko01200,map00630,map00680,map00920,map01100,map01120,map01200	-	R00519,R11487	RC00168,RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_7,Form-deh_trans
TLS2_k127_7106953_1	991905.SL003B_1279	8.079e-236	734.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2TTPX@28211|Alphaproteobacteria,4BT8J@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TLS2_k127_711556_8	717785.HYPMC_4189	1.633e-26	119.0	2965J@1|root,2ZTFS@2|Bacteria	2|Bacteria	S	Cellulose biosynthesis protein BcsS	-	-	-	-	-	-	-	-	-	-	-	-	CBP_BcsS
TLS2_k127_711556_10	582899.Hden_1672	9.066e-16	80.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	MA20_41765	-	-	-	-	-	-	-	-	-	-	-	DivIC
TLS2_k127_711556_1	717785.HYPMC_4148	1.585e-300	930.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,3N6AK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	etf	GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8,Thi4
TLS2_k127_711556_2	1267005.KB911255_gene2970	9.29e-98	334.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2TT4Q@28211|Alphaproteobacteria,3N6QU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Phage SPO1 DNA	udgA	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_711556_3	1121861.KB899926_gene2663	6.99e-97	324.0	COG0778@1|root,COG0778@2|Bacteria,1NIJ8@1224|Proteobacteria,2TUQN@28211|Alphaproteobacteria,2JWUG@204441|Rhodospirillales	204441|Rhodospirillales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_711556_9	596151.DesfrDRAFT_1855	9.716e-19	94.0	COG2207@1|root,COG3449@1|root,COG2207@2|Bacteria,COG3449@2|Bacteria,1MWTF@1224|Proteobacteria,42RC6@68525|delta/epsilon subdivisions,2WN72@28221|Deltaproteobacteria,2MA1Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	transcription activator, effector binding	-	-	-	ko:K13652	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18
TLS2_k127_711556_4	1120983.KB894571_gene2495	9.392e-79	272.0	COG2304@1|root,COG2304@2|Bacteria,1PH4N@1224|Proteobacteria,2TQTJ@28211|Alphaproteobacteria,1JNUX@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1194
TLS2_k127_711556_6	717785.HYPMC_0553	5.215e-49	178.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2UCCR@28211|Alphaproteobacteria,3N718@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS2_k127_711556_0	1267005.KB911265_gene3596	0.0	1082.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,3N6E3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS2_k127_711556_7	1267005.KB911265_gene3597	9.009e-46	170.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,3N6H7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	PD-(D/E)XK nuclease superfamily	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
TLS2_k127_714311_9	384765.SIAM614_24002	6.969e-55	196.0	COG0071@1|root,COG0071@2|Bacteria,1RH2X@1224|Proteobacteria,2U96D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	ibpA	-	-	ko:K04080	-	-	-	-	ko00000,ko03110	-	-	-	HSP20
TLS2_k127_714311_3	331869.BAL199_12236	5.108e-99	334.0	COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2UNXP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	MA20_01265	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_714311_1	622637.KE124774_gene2827	7.621e-112	372.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2TS3N@28211|Alphaproteobacteria,36XNR@31993|Methylocystaceae	28211|Alphaproteobacteria	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS2_k127_714311_5	1187851.A33M_2814	7.292e-74	255.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2U6EM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	LemA family	MA20_42455	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
TLS2_k127_714311_2	1267005.KB911256_gene1967	4.029e-111	376.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2TQZ1@28211|Alphaproteobacteria,3N6UQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
TLS2_k127_714311_0	1123072.AUDH01000011_gene3652	8.32e-132	426.0	COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,2TREP@28211|Alphaproteobacteria,2JPSQ@204441|Rhodospirillales	204441|Rhodospirillales	S	Alpha/beta hydrolase family	-	-	3.8.1.3	ko:K01561	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_714311_12	1267005.KB911256_gene1880	6.895e-19	99.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_714311_4	1267005.KB911260_gene3538	1.31e-85	285.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2U591@28211|Alphaproteobacteria,3N6NE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K01802,ko:K09565	ko04020,ko04022,ko05012,ko05016,ko05145,map04020,map04022,map05012,map05016,map05145	-	-	-	ko00000,ko00001,ko01000,ko03110	-	-	-	Pro_isomerase
TLS2_k127_714311_6	582899.Hden_2172	3.368e-66	231.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2U591@28211|Alphaproteobacteria,3N8HB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768,ko:K09565	ko01503,ko04020,ko04022,ko04217,ko05012,ko05016,ko05145,map01503,map04020,map04022,map04217,map05012,map05016,map05145	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
TLS2_k127_714311_7	670307.HYPDE_33798	5.67e-62	221.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2U74H@28211|Alphaproteobacteria,3N6XG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_714311_10	94122.Shewana3_0836	2.56e-28	122.0	COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,1S2KI@1236|Gammaproteobacteria,2QBQK@267890|Shewanellaceae	1236|Gammaproteobacteria	E	LysE type translocator	-	-	-	ko:K11250	-	-	-	-	ko00000,ko02000	2.A.76.1.5	-	-	LysE
TLS2_k127_714311_8	1089551.KE386572_gene3504	4.123e-59	209.0	COG0454@1|root,COG0456@2|Bacteria,1QUS0@1224|Proteobacteria,2TXDS@28211|Alphaproteobacteria,4BSKY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_714311_13	1267005.KB911263_gene1267	9.301e-11	63.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2TUKR@28211|Alphaproteobacteria,3N80F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
TLS2_k127_7254178_4	288000.BBta_6757	1.718e-22	102.0	COG0582@1|root,COG0582@2|Bacteria,1RAN4@1224|Proteobacteria,2U47D@28211|Alphaproteobacteria,3JVG1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS2_k127_7254178_0	1267005.KB911260_gene3476	1.617e-263	824.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TSCR@28211|Alphaproteobacteria,3N6E8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS2_k127_7254178_3	670307.HYPDE_34033	4.364e-59	206.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U73Z@28211|Alphaproteobacteria,3N6Y4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Belongs to the P(II) protein family	glnB	GO:0003674,GO:0006808,GO:0008150,GO:0030234,GO:0050789,GO:0050790,GO:0065007,GO:0065009,GO:0098772	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
TLS2_k127_7254178_1	1304878.AUGD01000001_gene203	3.345e-205	646.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2TSAD@28211|Alphaproteobacteria,3JS5T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Function of homologous gene experimentally demonstrated in an other organism	cbbA	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
TLS2_k127_7254178_5	1112204.GPOL_c01060	3.866e-05	57.0	COG0457@1|root,COG0457@2|Bacteria,2GNKM@201174|Actinobacteria,4GFR7@85026|Gordoniaceae	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7254178_2	1411123.JQNH01000001_gene3146	3.845e-177	571.0	COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,2TRK0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG2041 Sulfite oxidase and related enzymes	-	-	1.8.3.1	ko:K00387	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00533	RC00168	ko00000,ko00001,ko01000	-	-	-	Mo-co_dimer,Oxidored_molyb
TLS2_k127_726687_10	675635.Psed_6658	8.758e-52	192.0	COG1051@1|root,COG1051@2|Bacteria,2I5MF@201174|Actinobacteria,4EE73@85010|Pseudonocardiales	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_726687_8	909943.HIMB100_00006910	8.603e-63	230.0	COG0697@1|root,COG0697@2|Bacteria,1MX07@1224|Proteobacteria,2TQNT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_726687_2	1380394.JADL01000001_gene2945	1.237e-140	464.0	COG0747@1|root,COG0747@2|Bacteria,1MWGY@1224|Proteobacteria,2TR73@28211|Alphaproteobacteria,2JR9R@204441|Rhodospirillales	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_726687_6	177437.HRM2_12930	1.117e-122	401.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,43AFB@68525|delta/epsilon subdivisions,2WU0J@28221|Deltaproteobacteria,2MMVY@213118|Desulfobacterales	28221|Deltaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_726687_7	1207063.P24_00725	1.988e-119	391.0	COG1173@1|root,COG1173@2|Bacteria,1MXGS@1224|Proteobacteria,2TTQ7@28211|Alphaproteobacteria,2JQMK@204441|Rhodospirillales	204441|Rhodospirillales	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_726687_3	1207063.P24_00730	1.746e-137	445.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2JQ5Z@204441|Rhodospirillales	204441|Rhodospirillales	EP	COG0444 ABC-type dipeptide oligopeptide nickel transport system, ATPase component	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_726687_5	1380394.JADL01000001_gene2159	1.026e-132	437.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,2JR51@204441|Rhodospirillales	204441|Rhodospirillales	E	COG4608 ABC-type oligopeptide transport system, ATPase component	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_726687_1	1380394.JADL01000011_gene4048	7.553e-169	542.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2TTGM@28211|Alphaproteobacteria,2JPI4@204441|Rhodospirillales	204441|Rhodospirillales	E	Peptidase family M20/M25/M40	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_726687_9	717785.HYPMC_2137	3.516e-53	203.0	COG3016@1|root,COG3016@2|Bacteria,1NXYQ@1224|Proteobacteria,2U0QY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Iron-regulated protein	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg
TLS2_k127_726687_4	1122929.KB908221_gene2832	1.108e-133	432.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TT8N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	branched-chain amino acid	livF1	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_726687_0	1038859.AXAU01000015_gene927	2.821e-237	736.0	COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2TQZC@28211|Alphaproteobacteria,3JV9Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_7288769_0	670307.HYPDE_36393	0.0	1048.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,3N69N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	mutB	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
TLS2_k127_7288769_4	1297570.MESS4_310019	5.044e-36	144.0	COG0463@1|root,COG0463@2|Bacteria,1N8QE@1224|Proteobacteria,2UDFS@28211|Alphaproteobacteria,43HNH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_7288769_1	717785.HYPMC_1818	2.495e-185	597.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC-type multidrug transport system ATPase and permease	msbA	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_7288769_2	935548.KI912159_gene2052	2.815e-173	563.0	COG0463@1|root,COG4122@1|root,COG0463@2|Bacteria,COG4122@2|Bacteria,1R3W6@1224|Proteobacteria,2U3AF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_7288769_3	935548.KI912159_gene2052	3.737e-68	250.0	COG0463@1|root,COG4122@1|root,COG0463@2|Bacteria,COG4122@2|Bacteria,1R3W6@1224|Proteobacteria,2U3AF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_7360353_5	331869.BAL199_01114	1.587e-115	377.0	COG0687@1|root,COG0687@2|Bacteria,1PFAC@1224|Proteobacteria,2V7FX@28211|Alphaproteobacteria,4BR0X@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
TLS2_k127_7360353_2	331869.BAL199_01119	6.084e-161	514.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,4BR7A@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	TOBE domain	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
TLS2_k127_7360353_4	331869.BAL199_01124	5.309e-121	394.0	COG1177@1|root,COG1177@2|Bacteria,1MWXM@1224|Proteobacteria,2TXYX@28211|Alphaproteobacteria,4BQPD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
TLS2_k127_7360353_0	331869.BAL199_01129	1.134e-200	633.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_7360353_1	331869.BAL199_01134	3.871e-200	630.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_7360353_3	398525.KB900701_gene3652	2.359e-159	508.0	COG0346@1|root,COG0346@2|Bacteria,1MUWY@1224|Proteobacteria,2TTMJ@28211|Alphaproteobacteria,3JRYD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	MA20_16260	-	1.13.11.2	ko:K00446	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
TLS2_k127_7377352_5	717785.HYPMC_4511	9.558e-160	510.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2TQNE@28211|Alphaproteobacteria,3N65E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the prokaryotic GSH synthase family	gshB	GO:0003674,GO:0003824,GO:0004363,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
TLS2_k127_7377352_21	1267005.KB911255_gene2576	1.232e-28	121.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,2UFTM@28211|Alphaproteobacteria,3N797@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the UPF0102 family	MA20_24645	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
TLS2_k127_7377352_13	1267005.KB911255_gene2577	2.588e-91	314.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2TR14@28211|Alphaproteobacteria,3N6RW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
TLS2_k127_7377352_14	1267005.KB911255_gene2578	1.384e-87	319.0	COG0683@1|root,COG0683@2|Bacteria,1QURG@1224|Proteobacteria,2TS62@28211|Alphaproteobacteria,3N717@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	LppC putative lipoprotein	MA20_24635	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
TLS2_k127_7377352_6	717785.HYPMC_4603	1.375e-159	504.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2TQYF@28211|Alphaproteobacteria,3N6IS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_17,Fer4_8
TLS2_k127_7377352_7	452637.Oter_3899	9.252e-143	489.0	COG0471@1|root,COG3273@1|root,COG0471@2|Bacteria,COG3273@2|Bacteria,46UA9@74201|Verrucomicrobia,3K7MZ@414999|Opitutae	414999|Opitutae	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
TLS2_k127_7377352_16	1469245.JFBG01000009_gene565	7.268e-71	252.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RQNH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Rhodanese-like domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS2_k127_7377352_8	1267005.KB911256_gene1948	1.242e-141	454.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2TRT6@28211|Alphaproteobacteria,3N68F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_7377352_9	1267005.KB911256_gene1949	1.81e-135	444.0	COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRD2@28211|Alphaproteobacteria,3N7KH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	lytic murein transglycosylase	MA20_01345	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,SLT_2
TLS2_k127_7377352_12	1267005.KB911256_gene1950	5.871e-101	347.0	COG2845@1|root,COG2845@2|Bacteria,1R4X7@1224|Proteobacteria,2U5AU@28211|Alphaproteobacteria,3N771@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF459)	-	-	-	ko:K09795	-	-	-	-	ko00000	-	-	-	DUF459
TLS2_k127_7377352_3	1267005.KB911257_gene709	2.466e-233	734.0	COG2303@1|root,COG2303@2|Bacteria,1QQ8F@1224|Proteobacteria,2U7D4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EI	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS2_k127_7377352_20	631454.N177_3898	2.644e-50	188.0	COG4957@1|root,COG4957@2|Bacteria,1RGUW@1224|Proteobacteria,2U99M@28211|Alphaproteobacteria,1JP53@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	ROS/MUCR transcriptional regulator protein	MA20_15715	-	-	-	-	-	-	-	-	-	-	-	ROS_MUCR
TLS2_k127_7377352_18	472175.EL18_01720	9.216e-59	206.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U70T@28211|Alphaproteobacteria,43KM3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
TLS2_k127_7377352_2	670307.HYPDE_32208	0.0	1027.0	COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,2TTR0@28211|Alphaproteobacteria,3N62G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	ptrB	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_7377352_23	582744.Msip34_1608	4.723e-13	74.0	2F046@1|root,33T7V@2|Bacteria,1NRUJ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7377352_24	582744.Msip34_1608	1.824e-07	58.0	2F046@1|root,33T7V@2|Bacteria,1NRUJ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7377352_17	1510531.JQJJ01000016_gene3133	4.646e-65	226.0	COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2VG6E@28211|Alphaproteobacteria,3JSFH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix ASNC type	MA20_17015	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24
TLS2_k127_7377352_1	1502851.FG93_05902	0.0	1047.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2TSZ9@28211|Alphaproteobacteria,3JRFU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	MA20_17010	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS2_k127_7377352_11	670307.HYPDE_36218	9.415e-105	351.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2TUHX@28211|Alphaproteobacteria,3N6Q0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	cytochrome c1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
TLS2_k127_7377352_4	1267005.KB911256_gene2059	4.542e-227	708.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2TSZ3@28211|Alphaproteobacteria,3N6F6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00410,ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
TLS2_k127_7377352_15	582899.Hden_2528	9.38e-83	281.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2TTT2@28211|Alphaproteobacteria,3N6V2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
TLS2_k127_7377352_19	717785.HYPMC_0912	8.447e-58	205.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,2U78W@28211|Alphaproteobacteria,3N6Z6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
TLS2_k127_7377352_10	1366046.HIMB11_01194	2.006e-105	347.0	COG5285@1|root,COG5285@2|Bacteria,1PF68@1224|Proteobacteria,2U1TB@28211|Alphaproteobacteria,3ZGKP@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	C	Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS2_k127_7377352_22	1267005.KB911260_gene3555	1.593e-26	117.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2UC5G@28211|Alphaproteobacteria,3N7A9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_7377352_0	1267005.KB911260_gene3554	0.0	1247.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,3N6J9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS2_k127_7382366_7	318996.AXAZ01000039_gene636	8.164e-33	133.0	COG3631@1|root,COG3631@2|Bacteria,1P5A2@1224|Proteobacteria,2TV5B@28211|Alphaproteobacteria,3JR2U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	SnoaL-like domain	MA20_24415	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS2_k127_7382366_6	1125863.JAFN01000001_gene1797	4.215e-38	148.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2WQ6E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
TLS2_k127_7382366_1	1267005.KB911257_gene1091	3.766e-170	542.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria,3N6B6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
TLS2_k127_7382366_2	1207063.P24_06506	1.911e-116	396.0	COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,2TRTW@28211|Alphaproteobacteria,2JTGE@204441|Rhodospirillales	204441|Rhodospirillales	E	Peptidase dimerisation domain	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_7382366_3	909943.HIMB100_00006910	3.709e-43	170.0	COG0697@1|root,COG0697@2|Bacteria,1MX07@1224|Proteobacteria,2TQNT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_7382366_4	536019.Mesop_5163	2.089e-42	160.0	COG3278@1|root,COG3278@2|Bacteria,1N9ZN@1224|Proteobacteria,2UFRF@28211|Alphaproteobacteria,43KNY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	signal peptide protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7382366_9	187303.BN69_2797	1.207e-15	79.0	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,2UJCE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
TLS2_k127_7382366_8	582899.Hden_3423	7.371e-25	117.0	COG0594@1|root,COG0594@2|Bacteria,1N6QY@1224|Proteobacteria,2VAIX@28211|Alphaproteobacteria,3N7D5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
TLS2_k127_7382366_0	1267005.KB911255_gene2392	6.14e-236	746.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2TSTJ@28211|Alphaproteobacteria,3N62W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
TLS2_k127_7382366_5	685778.AORL01000016_gene2311	2.783e-39	161.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2U5E5@28211|Alphaproteobacteria,2K0SN@204457|Sphingomonadales	204457|Sphingomonadales	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
TLS2_k127_784160_6	402881.Plav_2273	6.695e-45	171.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2U73K@28211|Alphaproteobacteria,1JP07@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	MoaE protein	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
TLS2_k127_784160_7	426355.Mrad2831_5403	1.352e-32	130.0	COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2UF4F@28211|Alphaproteobacteria,1JVMU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS2_k127_784160_3	1267005.KB911255_gene3034	1.976e-79	271.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2TUI7@28211|Alphaproteobacteria,3N6XZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_784160_0	1267005.KB911263_gene1390	1.624e-270	840.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2TRIJ@28211|Alphaproteobacteria,3N7JP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain II	algC	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_784160_1	1265756.AWZW01000008_gene1254	3.456e-199	631.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,4BRA7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	TIGRFAM TRAP transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
TLS2_k127_784160_5	859653.HIMB5_00005210	2.8e-65	228.0	COG4665@1|root,COG4665@2|Bacteria,1QZG7@1224|Proteobacteria	1224|Proteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS2_k127_784160_2	744979.R2A130_1221	1.164e-166	533.0	COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS2_k127_784160_4	78245.Xaut_3075	1.897e-75	254.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TR6E@28211|Alphaproteobacteria,3EY73@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TLS2_k127_797597_0	1125973.JNLC01000010_gene1908	0.0	1249.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,3JTMR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	soxA	-	1.5.3.1,1.5.99.5	ko:K00302,ko:K22086	ko00260,ko00680,ko01100,ko01120,map00260,map00680,map01100,map01120	-	R00609,R00610	RC00060,RC00190,RC00557	ko00000,ko00001,ko01000	-	-	-	FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
TLS2_k127_797597_2	1038858.AXBA01000002_gene3816	3.091e-27	120.0	COG4583@1|root,COG4583@2|Bacteria,1N7CP@1224|Proteobacteria,2UHEZ@28211|Alphaproteobacteria,3EZU8@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Sarcosine oxidase, gamma subunit family	soxG	-	1.5.99.5	ko:K22087	ko00680,ko01120,map00680,map01120	-	R00609	RC00190,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxG
TLS2_k127_797597_1	582899.Hden_3164	4.747e-94	323.0	COG4246@1|root,COG4246@2|Bacteria,1N7Y1@1224|Proteobacteria,2TTZW@28211|Alphaproteobacteria,3N746@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Esterase-like activity of phytase	-	-	-	-	-	-	-	-	-	-	-	-	Phytase-like
TLS2_k127_797597_3	1333998.M2A_1921	5.107e-12	66.0	COG4547@1|root,COG4547@2|Bacteria,1MX11@1224|Proteobacteria,2TS4N@28211|Alphaproteobacteria,4BPRN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Cobalamin biosynthesis protein CobT	cobT	-	6.6.1.2	ko:K09883	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobT,CobT_C
TLS2_k127_81873_1	717785.HYPMC_3179	3.82e-145	469.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2TT38@28211|Alphaproteobacteria,3N68H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
TLS2_k127_81873_2	1267005.KB911255_gene2611	2.643e-87	294.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2U9DF@28211|Alphaproteobacteria,3N6WT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
TLS2_k127_81873_5	1094558.ME5_01515	7.342e-64	220.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2U73D@28211|Alphaproteobacteria,48U1Y@772|Bartonellaceae	28211|Alphaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
TLS2_k127_81873_4	1267005.KB911261_gene2218	4.059e-67	229.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,2U717@28211|Alphaproteobacteria,3N6U0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
TLS2_k127_81873_0	582899.Hden_1041	6.967e-195	612.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2TSI0@28211|Alphaproteobacteria,3N68P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
TLS2_k127_81873_3	1267005.KB911261_gene2216	7.23e-69	235.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,3N6TQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
TLS2_k127_8266_3	1532558.JL39_12110	1.796e-164	524.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2TS09@28211|Alphaproteobacteria,4B9UD@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS2_k127_8266_0	1267005.KB911256_gene1833	0.0	1035.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2TS97@28211|Alphaproteobacteria,3N680@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NADH-quinone oxidoreductase	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C
TLS2_k127_8266_10	1120983.KB894572_gene2817	2.998e-95	319.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQMB@28211|Alphaproteobacteria,1JNUT@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
TLS2_k127_8266_7	398525.KB900701_gene906	1.385e-146	474.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,3JTE3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
TLS2_k127_8266_11	323097.Nham_0711	7.836e-94	330.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TSWK@28211|Alphaproteobacteria,3JSRV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	MA20_22905	-	-	ko:K19595	-	M00768,M00769	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2.25,2.A.6.2.34,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TLS2_k127_8266_15	278957.ABEA03000014_gene2547	5.962e-38	152.0	2BHQ4@1|root,32BTD@2|Bacteria,46ZM0@74201|Verrucomicrobia,3K9Y0@414999|Opitutae	414999|Opitutae	S	PhoP regulatory network protein YrbL	-	-	-	-	-	-	-	-	-	-	-	-	YrbL-PhoP_reg
TLS2_k127_8266_5	1380394.JADL01000001_gene3072	2.468e-148	479.0	COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2TR20@28211|Alphaproteobacteria,2JPF7@204441|Rhodospirillales	204441|Rhodospirillales	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
TLS2_k127_8266_14	420324.KI912069_gene6356	1.221e-58	207.0	COG1672@1|root,COG1672@2|Bacteria,1N05N@1224|Proteobacteria,2UBUA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Electron transfer DM13	-	-	-	-	-	-	-	-	-	-	-	-	DM13
TLS2_k127_8266_6	717785.HYPMC_1141	1.099e-147	481.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2TSV7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	cytochrome P450	cyc	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_8266_1	717785.HYPMC_0100	7.475e-257	803.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR78@28211|Alphaproteobacteria,3N6XV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	PFAM acyl-CoA dehydrogenase	mcd	-	1.3.8.12	ko:K14448	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09293	RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_8266_9	1267005.KB911256_gene2036	6.046e-98	333.0	28NTG@1|root,2ZBS3@2|Bacteria,1N1KZ@1224|Proteobacteria,2TQM9@28211|Alphaproteobacteria,3N819@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_8266_2	536019.Mesop_4152	4.902e-246	772.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,43HJ3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefB	-	-	ko:K03455,ko:K11745,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.1,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
TLS2_k127_8266_17	935261.JAGL01000007_gene2557	6.207e-21	95.0	2E628@1|root,330RC@2|Bacteria,1N6W8@1224|Proteobacteria,2UJTH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_8266_12	1380394.JADL01000012_gene823	9.328e-67	244.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2TS48@28211|Alphaproteobacteria,2JRFE@204441|Rhodospirillales	204441|Rhodospirillales	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_8266_16	1297865.APJD01000020_gene129	1.179e-29	122.0	COG2329@1|root,COG2329@2|Bacteria,1RCYM@1224|Proteobacteria,2U7PT@28211|Alphaproteobacteria,3K6AH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_8266_8	479434.Sthe_0124	1.893e-107	361.0	COG0477@1|root,COG2814@2|Bacteria,2G6DM@200795|Chloroflexi,27YS9@189775|Thermomicrobia	189775|Thermomicrobia	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_8266_4	1131814.JAFO01000001_gene1578	3.193e-155	499.0	COG2223@1|root,COG2223@2|Bacteria,1QVKP@1224|Proteobacteria,2TRVV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_8266_13	398525.KB900701_gene4558	1.578e-59	211.0	COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2TT84@28211|Alphaproteobacteria,3JTYR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0061 (SELO) family	MA20_28420	-	-	ko:K08997	-	-	-	-	ko00000	-	-	-	UPF0061
TLS2_k127_88001_13	420324.KI911965_gene915	2.45e-21	93.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,1JSW8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_88001_7	438753.AZC_0802	1.835e-118	389.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,3EY7Y@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	paaF	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_88001_9	717785.HYPMC_4767	1.249e-64	227.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2TS4E@28211|Alphaproteobacteria,3N6X2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
TLS2_k127_88001_2	1267005.KB911262_gene3339	1.14e-271	844.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,3N6I0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
TLS2_k127_88001_11	1267005.KB911262_gene3340	1.485e-50	190.0	COG2740@1|root,COG2740@2|Bacteria,1RHPR@1224|Proteobacteria,2U9RY@28211|Alphaproteobacteria,3N71Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Protein of unknown function (DUF448)	MA20_23920	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448,Ribosomal_L7Ae
TLS2_k127_88001_1	1267005.KB911262_gene3341	0.0	1079.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria,3N6B5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
TLS2_k127_88001_10	717785.HYPMC_4763	2.263e-51	192.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2UCJF@28211|Alphaproteobacteria,3N72E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
TLS2_k127_88001_6	717785.HYPMC_4762	5.031e-133	431.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2TSJK@28211|Alphaproteobacteria,3N6QH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
TLS2_k127_88001_5	1267005.KB911256_gene2026	1.183e-140	466.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2U139@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
TLS2_k127_88001_8	1267005.KB911256_gene2027	7.617e-101	336.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2TS3W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_88001_4	1267005.KB911256_gene2028	5.376e-161	527.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2TW3U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_88001_0	1267005.KB911255_gene2879	0.0	1148.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,3N6HJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	penicillin-binding protein	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
TLS2_k127_88001_12	318586.Pden_3215	5.383e-36	141.0	COG0599@1|root,COG0599@2|Bacteria,1RJU6@1224|Proteobacteria,2U5JQ@28211|Alphaproteobacteria,2PYNP@265|Paracoccus	28211|Alphaproteobacteria	S	carboxymuconolactone decarboxylase	pcaC	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
TLS2_k127_88001_3	1333998.M2A_2635	1.765e-199	631.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,4BPXD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Aminotransferase class-III	-	-	2.6.1.96	ko:K16871	ko00250,ko00650,ko01100,ko01120,map00250,map00650,map01100,map01120	M00027	R10178	RC00008,RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_3
TLS2_k127_887301_1	1304877.KI519401_gene48	1.027e-169	541.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,3JVKG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_887301_4	1038860.AXAP01000002_gene4980	1.726e-107	363.0	COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2TTZU@28211|Alphaproteobacteria,3JSN1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_887301_5	420324.KI912063_gene6822	1.463e-32	133.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria,1JY02@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_887301_3	1411123.JQNH01000001_gene914	1.19e-132	433.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2TUQ1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_887301_2	189753.AXAS01000016_gene1542	2.327e-169	539.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,3JTMF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Thiolase, N-terminal domain	MA20_27255	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_887301_6	196490.AUEZ01000012_gene4876	2.178e-27	123.0	COG1545@1|root,COG1545@2|Bacteria,1RDFZ@1224|Proteobacteria,2U8BV@28211|Alphaproteobacteria,3JYUU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF35_N,OB_aCoA_assoc
TLS2_k127_887301_0	316055.RPE_2375	4.518e-230	731.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,3JRT1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
TLS2_k127_924923_0	1267005.KB911258_gene365	5.376e-137	445.0	COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria,3N62D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Terminase RNaseH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
TLS2_k127_924923_4	582899.Hden_0313	9.886e-36	143.0	COG4961@1|root,COG4961@2|Bacteria,1N3XK@1224|Proteobacteria,2UBRJ@28211|Alphaproteobacteria,3N7E9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	TadE-like protein	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	TadE
TLS2_k127_924923_7	1333998.M2A_1841	4.616e-23	107.0	COG4961@1|root,COG4961@2|Bacteria,1N744@1224|Proteobacteria,2UGR2@28211|Alphaproteobacteria,4BSPB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	U	Flp pilus assembly protein TadG	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS2_k127_924923_2	754035.Mesau_04492	2.683e-72	248.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2U5B5@28211|Alphaproteobacteria,43GR2@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
TLS2_k127_924923_1	1082932.ATCR1_01005	6.315e-73	250.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2U5FM@28211|Alphaproteobacteria,4B9QY@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
TLS2_k127_924923_5	1411123.JQNH01000001_gene1064	6.68e-35	141.0	COG2050@1|root,COG2050@2|Bacteria,1MZRJ@1224|Proteobacteria,2U9BM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	protein possibly involved in aromatic compounds catabolism	MA20_36950	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_924923_6	876269.ARWA01000001_gene1414	2.589e-31	129.0	2ED53@1|root,3371U@2|Bacteria,1MUY2@1224|Proteobacteria,2U1AB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_924923_3	1267005.KB911256_gene2087	3.237e-63	224.0	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2TTMB@28211|Alphaproteobacteria,3N8G3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	Echdc	-	-	-	-	-	-	-	-	-	-	-	ECH_1
## 3454 queries scanned
## Total time (seconds): 77.61492252349854
## Rate: 44.50 q/s