## Thu Feb 19 19:39:15 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/TLS2_bin.66.fa -m mmseqs --output TLS2_bin.66 --output_dir /data/result/bins/wyx/eggqs50+/TLS2_bin.66 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TLS2_k127_1016323_27	351607.Acel_0065	7.608e-20	99.0	2DP8R@1|root,32UKH@2|Bacteria,2IFBP@201174|Actinobacteria,4EWH3@85013|Frankiales	201174|Actinobacteria	-	-	amfC	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1016323_29	1229780.BN381_60052	6.05e-18	86.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	moaD	-	2.8.1.12	ko:K03636,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
TLS2_k127_1016323_18	1449353.JQMQ01000005_gene4090	1.078e-51	188.0	COG1670@1|root,COG1670@2|Bacteria,2IFMK@201174|Actinobacteria,2NI9K@228398|Streptacidiphilus	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.57,2.3.1.82	ko:K00657,ko:K00663	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_3,Acetyltransf_8
TLS2_k127_1016323_33	1429046.RR21198_5255	7.515e-09	61.0	COG1595@1|root,COG1595@2|Bacteria,2GKBH@201174|Actinobacteria,4FV6H@85025|Nocardiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_1016323_24	1240349.ANGC01000002_gene2322	1.473e-26	116.0	COG1595@1|root,COG1595@2|Bacteria,2GKBH@201174|Actinobacteria,4FV6H@85025|Nocardiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_1016323_19	1229780.BN381_60053	7.408e-51	187.0	COG0406@1|root,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria,3UWZM@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Belongs to the phosphoglycerate mutase family	-	-	-	ko:K15640	-	-	-	-	ko00000	-	-	-	His_Phos_1
TLS2_k127_1016323_3	1282876.BAOK01000001_gene2723	6.233e-162	521.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2015, Alkyl sulfatase and related hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_dimr,Lactamase_B
TLS2_k127_1016323_0	1123322.KB904691_gene4384	0.0	1077.0	COG4581@1|root,COG4581@2|Bacteria,2GJSV@201174|Actinobacteria	201174|Actinobacteria	L	dead DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DUF3516,Helicase_C
TLS2_k127_1016323_10	298655.KI912266_gene1717	3.318e-92	317.0	COG0784@1|root,COG2208@1|root,COG0784@2|Bacteria,COG2208@2|Bacteria,2GNAF@201174|Actinobacteria,4ETRI@85013|Frankiales	201174|Actinobacteria	T	SMART protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,SpoIIE
TLS2_k127_1016323_9	106370.Francci3_0291	3.55e-103	370.0	COG4251@1|root,COG5278@1|root,COG4251@2|Bacteria,COG5278@2|Bacteria,2GK25@201174|Actinobacteria,4EURC@85013|Frankiales	201174|Actinobacteria	T	CHASE3 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HAMP,HATPase_c,HisKA
TLS2_k127_1016323_15	1123320.KB889669_gene3184	9.912e-57	203.0	COG0784@1|root,COG0784@2|Bacteria,2IFH8@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	rcp1	-	-	ko:K02485	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg
TLS2_k127_1016323_6	1123320.KB889562_gene6799	4.618e-129	419.0	COG1595@1|root,COG1595@2|Bacteria,2GMRK@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
TLS2_k127_1016323_34	67281.JNZZ01000023_gene3993	5.879e-08	59.0	2B42Y@1|root,31WTH@2|Bacteria,2INUX@201174|Actinobacteria,41BG0@629295|Streptomyces griseus group	201174|Actinobacteria	S	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
TLS2_k127_1016323_26	1096546.WYO_2393	5.633e-22	109.0	COG1051@1|root,COG1051@2|Bacteria,1RH1H@1224|Proteobacteria,2UIPI@28211|Alphaproteobacteria,1JV07@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_1016323_12	1123023.JIAI01000021_gene2347	4.59e-75	268.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS2_k127_1016323_14	547163.BN979_03383	7.125e-62	218.0	COG3651@1|root,COG3651@2|Bacteria,2IHNI@201174|Actinobacteria,2396K@1762|Mycobacteriaceae	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	ko:K09966	-	-	-	-	ko00000	-	-	-	DUF2237
TLS2_k127_1016323_1	1229780.BN381_290049	1.481e-220	702.0	COG2015@1|root,COG2015@2|Bacteria,2GK38@201174|Actinobacteria	201174|Actinobacteria	Q	COG2015 Alkyl sulfatase and related hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
TLS2_k127_1016323_8	1313172.YM304_18940	1.08e-105	354.0	COG2141@1|root,COG2141@2|Bacteria,2GMUE@201174|Actinobacteria,4CNUE@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_1016323_17	479434.Sthe_0621	6.331e-56	209.0	COG5401@1|root,COG5401@2|Bacteria,2GA61@200795|Chloroflexi,27Y9M@189775|Thermomicrobia	189775|Thermomicrobia	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
TLS2_k127_1016323_2	1333998.M2A_1395	3.045e-190	609.0	COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,2U3CV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_1016323_13	350058.Mvan_4623	6.568e-73	257.0	COG0300@1|root,COG0300@2|Bacteria,2I64P@201174|Actinobacteria,234PI@1762|Mycobacteriaceae	201174|Actinobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_1016323_7	1449126.JQKL01000005_gene853	4.337e-125	419.0	COG0651@1|root,COG0651@2|Bacteria,1TRAT@1239|Firmicutes,24AZH@186801|Clostridia	186801|Clostridia	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05568,ko:K12141	-	-	-	-	ko00000,ko01000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
TLS2_k127_1016323_23	1232410.KI421424_gene1712	1.23e-26	120.0	COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria,42SX0@68525|delta/epsilon subdivisions,2WP3K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	NADH-ubiquinone oxidoreductase, chain 4L	mnhC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
TLS2_k127_1016323_25	1121930.AQXG01000002_gene2026	1.26e-23	106.0	COG2111@1|root,COG2111@2|Bacteria,4P6YI@976|Bacteroidetes	976|Bacteroidetes	P	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	-	-	-	-	-	-	-	-	-	MnhB
TLS2_k127_1016323_22	1131269.AQVV01000014_gene189	1.66e-27	125.0	COG2111@1|root,COG2111@2|Bacteria	2|Bacteria	P	Na H antiporter	mnhB	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB
TLS2_k127_1016323_30	1304888.ATWF01000002_gene130	8.137e-12	74.0	COG1320@1|root,COG1320@2|Bacteria,2GG0R@200930|Deferribacteres	200930|Deferribacteres	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
TLS2_k127_1016323_31	1121413.JMKT01000008_gene1532	3.039e-11	74.0	COG2212@1|root,COG2212@2|Bacteria,1Q6VH@1224|Proteobacteria,42VZI@68525|delta/epsilon subdivisions,2WSAW@28221|Deltaproteobacteria,2MFZR@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	-	-	-	-	-	-	-	-	-	-	-	-	MrpF_PhaF
TLS2_k127_1016323_28	574087.Acear_1090	1.407e-18	96.0	COG1863@1|root,COG1863@2|Bacteria,1VEJ0@1239|Firmicutes,24REY@186801|Clostridia	186801|Clostridia	P	PFAM cation antiporter	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
TLS2_k127_1016323_5	1125863.JAFN01000001_gene2554	5.663e-134	445.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,42MSA@68525|delta/epsilon subdivisions,2WIS1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05568,ko:K12137	-	-	-	-	ko00000,ko01000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
TLS2_k127_1016323_4	1125863.JAFN01000001_gene2556	1.685e-148	486.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,42MDX@68525|delta/epsilon subdivisions,2WJ56@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
TLS2_k127_1016323_21	570967.JMLV01000001_gene2566	6.968e-29	124.0	COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2UA0Y@28211|Alphaproteobacteria,2JT6Z@204441|Rhodospirillales	204441|Rhodospirillales	O	HupE / UreJ protein	-	-	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
TLS2_k127_1016323_16	452652.KSE_20740	3.571e-56	199.0	COG2606@1|root,COG2606@2|Bacteria,2IHS8@201174|Actinobacteria,2M312@2063|Kitasatospora	201174|Actinobacteria	S	Aminoacyl-tRNA editing domain	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
TLS2_k127_1016323_32	7370.XP_005180891.1	3.387e-11	77.0	2CMNT@1|root,2QR3D@2759|Eukaryota,39UHX@33154|Opisthokonta,3B9U3@33208|Metazoa,3D2YM@33213|Bilateria,4201I@6656|Arthropoda,3SN7B@50557|Insecta,4553X@7147|Diptera	33208|Metazoa	G	Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family	-	GO:0000270,GO:0002376,GO:0002682,GO:0002683,GO:0003674,GO:0003824,GO:0005488,GO:0005539,GO:0005575,GO:0005576,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0008150,GO:0008152,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0016787,GO:0016810,GO:0016811,GO:0030203,GO:0031347,GO:0031348,GO:0042834,GO:0043170,GO:0045087,GO:0045088,GO:0045824,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0061783,GO:0065007,GO:0071704,GO:0080134,GO:0097367,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	-	ko:K01446	-	-	R04112	RC00064,RC00141	ko00000	-	-	-	Amidase_2
TLS2_k127_1016323_11	1242864.D187_004691	3.867e-78	277.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria	1224|Proteobacteria	Q	Acyltransferase, ws dgat mgat	-	-	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
TLS2_k127_1039710_6	471852.Tcur_1751	2.862e-27	117.0	COG0730@1|root,COG0730@2|Bacteria,2IIY7@201174|Actinobacteria,4EJN8@85012|Streptosporangiales	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_1039710_1	1894.JOER01000021_gene4019	2.881e-87	299.0	COG0657@1|root,COG0657@2|Bacteria,2I6Z1@201174|Actinobacteria	201174|Actinobacteria	I	Esterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS2_k127_1039710_3	1120949.KB903331_gene3403	3.546e-56	202.0	COG2353@1|root,COG2353@2|Bacteria,2GJUB@201174|Actinobacteria,4D9KN@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
TLS2_k127_1039710_2	1179773.BN6_24800	3.153e-80	284.0	COG5438@1|root,COG5438@2|Bacteria,2GKJ4@201174|Actinobacteria,4DY5S@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM YibE F-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YibE_F
TLS2_k127_1039710_5	479432.Sros_6709	1.646e-40	159.0	COG1985@1|root,COG1985@2|Bacteria,2GN2P@201174|Actinobacteria,4EFXN@85012|Streptosporangiales	201174|Actinobacteria	H	RibD C-terminal domain	-	-	1.1.1.193	ko:K00082	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R03458	RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C
TLS2_k127_1039710_0	67257.JODR01000034_gene1441	1.116e-102	355.0	COG1804@1|root,COG1804@2|Bacteria,2I9RM@201174|Actinobacteria	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_1039710_4	1313172.YM304_26950	5.707e-45	171.0	COG1327@1|root,COG1327@2|Bacteria,2IHU9@201174|Actinobacteria,4CN4B@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
TLS2_k127_1058342_6	479435.Kfla_6045	6.327e-06	51.0	COG3187@1|root,COG3187@2|Bacteria,2I9ND@201174|Actinobacteria,4DUY5@85009|Propionibacteriales	201174|Actinobacteria	O	META domain	hslJ	-	-	ko:K03668	-	-	-	-	ko00000	-	-	-	META
TLS2_k127_1058342_4	1313172.YM304_36470	6.999e-96	318.0	COG0692@1|root,COG0692@2|Bacteria,2GJ9Z@201174|Actinobacteria	201174|Actinobacteria	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	ung	GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_1058342_1	926560.KE387023_gene2049	3.312e-134	453.0	COG5001@1|root,COG5001@2|Bacteria,1WK20@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4
TLS2_k127_1058342_2	1313172.YM304_36420	1.078e-130	438.0	COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,4CP51@84992|Acidimicrobiia	201174|Actinobacteria	IQ	Protein synonym acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_1058342_0	1048339.KB913029_gene1969	3.024e-140	501.0	COG0410@1|root,COG0411@1|root,COG0410@2|Bacteria,COG0411@2|Bacteria,2H3P9@201174|Actinobacteria,4EXEI@85013|Frankiales	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
TLS2_k127_1058342_3	1229780.BN381_10242	4.423e-124	431.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJHR@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
TLS2_k127_1058342_5	1229780.BN381_10244	4.22e-69	256.0	2FACV@1|root,342M7@2|Bacteria,2H6AW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1065711_1	469383.Cwoe_0229	1.1e-84	287.0	COG1396@1|root,COG1396@2|Bacteria,2GK1R@201174|Actinobacteria,4CRR7@84995|Rubrobacteria	84995|Rubrobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
TLS2_k127_1065711_9	977880.RALTA_A0657	2.119e-21	99.0	COG2329@1|root,COG2329@2|Bacteria,1QTY7@1224|Proteobacteria,2WHMJ@28216|Betaproteobacteria,1KHE7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS2_k127_1065711_0	671143.DAMO_1031	2.534e-132	443.0	COG0155@1|root,COG0155@2|Bacteria,2NPHB@2323|unclassified Bacteria	2|Bacteria	P	Nitrite and sulphite reductase 4Fe-4S domain	cysI	-	1.7.1.15,1.7.7.1,1.8.1.2,1.8.7.1	ko:K00362,ko:K00366,ko:K00381,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00530,M00531	R00787,R00790,R00858,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	HEPN,NIR_SIR,NIR_SIR_ferr
TLS2_k127_1065711_8	1397528.Q671_15750	2.095e-39	166.0	COG1670@1|root,COG1670@2|Bacteria,1RB1I@1224|Proteobacteria,1S7ZE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Domain of unknown function (DUF4202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4202
TLS2_k127_1065711_3	208439.AJAP_41540	5.13e-55	201.0	COG0563@1|root,COG0563@2|Bacteria,2I8TV@201174|Actinobacteria,4EDFW@85010|Pseudonocardiales	201174|Actinobacteria	F	adenylate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1065711_6	1385511.N783_05635	6.802e-41	156.0	COG0537@1|root,COG0537@2|Bacteria,1VB6J@1239|Firmicutes,4HIE1@91061|Bacilli,2YBJS@289201|Pontibacillus	91061|Bacilli	FG	Cell-cycle regulation histidine triad	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
TLS2_k127_1065711_5	1449353.JQMQ01000005_gene1416	1.157e-46	173.0	COG2050@1|root,COG2050@2|Bacteria,2IQXX@201174|Actinobacteria	201174|Actinobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_1065711_2	1211815.CBYP010000060_gene3102	3.759e-70	243.0	COG0412@1|root,COG0412@2|Bacteria,2GTZG@201174|Actinobacteria	201174|Actinobacteria	Q	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS2_k127_1065711_4	159087.Daro_3750	1.255e-47	189.0	COG0715@1|root,COG2199@1|root,COG0715@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2WGZJ@28216|Betaproteobacteria,2KVQZ@206389|Rhodocyclales	206389|Rhodocyclales	T	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,NMT1,PAS_4
TLS2_k127_1065711_7	1289387.AUKW01000003_gene2472	1.428e-40	157.0	COG1670@1|root,COG1670@2|Bacteria,2IS6V@201174|Actinobacteria	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_1065711_10	1229780.BN381_250093	5.868e-08	58.0	COG3714@1|root,COG3714@2|Bacteria	2|Bacteria	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
TLS2_k127_1065711_11	84531.JMTZ01000012_gene2997	5.126e-06	52.0	COG3714@1|root,COG3714@2|Bacteria,1N6QN@1224|Proteobacteria,1TAFV@1236|Gammaproteobacteria,1X74T@135614|Xanthomonadales	135614|Xanthomonadales	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
TLS2_k127_1120425_5	554065.XP_005845735.1	1.99e-22	111.0	COG3315@1|root,2QRNU@2759|Eukaryota,37Q2S@33090|Viridiplantae	33090|Viridiplantae	Q	Leucine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	LCM
TLS2_k127_1120425_0	1038859.AXAU01000003_gene5973	7.874e-316	974.0	COG2072@1|root,COG2072@2|Bacteria,1NSY9@1224|Proteobacteria,2TUSD@28211|Alphaproteobacteria,3JUMD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Flavin-binding monooxygenase-like	MA20_26775	-	1.14.13.22	ko:K03379	ko00930,ko01120,ko01220,map00930,map01120,map01220	-	R02231,R06622	RC00662,RC01550	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
TLS2_k127_1120425_6	469383.Cwoe_2612	7.753e-18	94.0	COG0491@1|root,COG0491@2|Bacteria,2HFVZ@201174|Actinobacteria,4CSB9@84995|Rubrobacteria	84995|Rubrobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_1120425_4	1122134.KB893650_gene846	7.142e-42	174.0	COG0670@1|root,COG0670@2|Bacteria,1R7VN@1224|Proteobacteria,1RNKS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the BI1 family	-	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
TLS2_k127_1120425_2	298653.Franean1_5555	1.928e-86	324.0	COG1752@1|root,COG1752@2|Bacteria,2IB41@201174|Actinobacteria,4EUJE@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3376)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3376,Patatin
TLS2_k127_1120425_3	33876.JNXY01000023_gene5145	3.184e-72	263.0	COG5001@1|root,COG5001@2|Bacteria,2IAJD@201174|Actinobacteria,4DIBZ@85008|Micromonosporales	201174|Actinobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3,PAS_4
TLS2_k127_1120425_1	1121377.KB906406_gene163	1.055e-101	341.0	COG3263@1|root,COG3263@2|Bacteria,1WJ46@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	COGs COG3263 NhaP-type Na H and K H antiporter with a unique C-terminal domain	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger,TrkA_C
TLS2_k127_1125605_2	693986.MOC_4682	1.513e-51	190.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,1JSQZ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,DUF4118,HATPase_c,HisKA,PAS_7,Response_reg
TLS2_k127_1125605_0	525909.Afer_0728	2.318e-179	569.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2GJB6@201174|Actinobacteria,4CMRS@84992|Acidimicrobiia	84992|Acidimicrobiia	HP	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,ThiF
TLS2_k127_1125605_1	1313172.YM304_28580	4.529e-70	254.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0008150,GO:0009987,GO:0044764,GO:0046812,GO:0051704	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	Polysacc_synt,Polysacc_synt_3
TLS2_k127_1125605_5	266940.Krad_0131	1.045e-11	76.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP
TLS2_k127_1125605_3	1336208.JADY01000015_gene1345	4.347e-23	110.0	COG1361@1|root,COG2340@1|root,COG2931@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2340@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HasA,HemolysinCabind
TLS2_k127_1125605_4	861299.J421_3248	1.517e-22	108.0	COG0438@1|root,COG0438@2|Bacteria,1ZSTJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_1159142_5	1137271.AZUM01000001_gene836	0.0003254	48.0	COG3409@1|root,COG3409@2|Bacteria,2ICQE@201174|Actinobacteria,4E2KH@85010|Pseudonocardiales	201174|Actinobacteria	M	Transglycosylase-like domain	-	-	-	ko:K21687	-	-	-	-	ko00000	-	GH23	-	PG_binding_1,Transglycosylas
TLS2_k127_1159142_0	287986.DV20_43285	2.968e-102	337.0	COG0491@1|root,COG0491@2|Bacteria,2GNS6@201174|Actinobacteria,4DZVJ@85010|Pseudonocardiales	201174|Actinobacteria	S	Zn-dependent hydrolase, glyoxylase	gloB	GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006090,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019184,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0042398,GO:0043043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0070013,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_1159142_2	1183438.GKIL_1662	1.363e-91	311.0	COG1893@1|root,COG1893@2|Bacteria,1G2H9@1117|Cyanobacteria	1117|Cyanobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
TLS2_k127_1159142_3	1380346.JNIH01000019_gene6116	1.17e-90	324.0	COG1641@1|root,COG1641@2|Bacteria,2I8J1@201174|Actinobacteria	201174|Actinobacteria	S	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
TLS2_k127_1159142_4	1254432.SCE1572_12410	8.423e-60	216.0	COG1691@1|root,COG1691@2|Bacteria,1REQ7@1224|Proteobacteria,42MJG@68525|delta/epsilon subdivisions,2WN0G@28221|Deltaproteobacteria,2YUU1@29|Myxococcales	28221|Deltaproteobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
TLS2_k127_1159142_1	1313172.YM304_02490	8.223e-99	334.0	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4CN0G@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
TLS2_k127_1201736_12	266940.Krad_0179	5.097e-51	205.0	COG2199@1|root,COG2200@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG2203@2|Bacteria,2GJNM@201174|Actinobacteria	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4,PAS_8
TLS2_k127_1201736_15	357808.RoseRS_2694	7.741e-22	111.0	COG0745@1|root,COG2114@1|root,COG2203@1|root,COG3283@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2203@2|Bacteria,COG3283@2|Bacteria,2G6X8@200795|Chloroflexi,374WS@32061|Chloroflexia	32061|Chloroflexia	T	PFAM adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,Guanylate_cyc,PAS_4,Response_reg
TLS2_k127_1201736_7	1313172.YM304_29050	4.542e-93	312.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4CNTU@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sir2 family	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
TLS2_k127_1201736_14	1313172.YM304_29090	1.927e-39	155.0	2BJWW@1|root,32E9A@2|Bacteria,2HGG7@201174|Actinobacteria,4CNDN@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1201736_5	1229780.BN381_80028	3.379e-131	434.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,3UWAR@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS2_k127_1201736_9	1229780.BN381_80027	9.809e-63	222.0	COG2096@1|root,COG2096@2|Bacteria,2GMHN@201174|Actinobacteria,3UWVY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Cobalamin adenosyltransferase	yvqK	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
TLS2_k127_1201736_0	1229780.BN381_80024	0.0	1530.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,3UW7W@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	B12 binding domain	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TLS2_k127_1201736_11	1210884.HG799467_gene13402	1.877e-51	207.0	COG5305@1|root,COG5305@2|Bacteria,2J08D@203682|Planctomycetes	203682|Planctomycetes	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_1201736_6	1229780.BN381_110033	4.496e-101	337.0	COG1215@1|root,COG1215@2|Bacteria,2GP1D@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_1201736_20	314230.DSM3645_01776	2.163e-06	59.0	2EEQZ@1|root,338IP@2|Bacteria,2J15B@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1201736_16	1380367.JIBC01000016_gene1132	7.557e-18	97.0	COG2340@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria,1R62B@1224|Proteobacteria,2U3MK@28211|Alphaproteobacteria,3ZZF6@60136|Sulfitobacter	28211|Alphaproteobacteria	Q	Domain of unknown function (DUF4214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,HemolysinCabind
TLS2_k127_1201736_3	1313172.YM304_15060	6.138e-140	454.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4CMRJ@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
TLS2_k127_1201736_17	1445613.JALM01000003_gene4974	6.183e-15	87.0	COG1960@1|root,COG1960@2|Bacteria,2HJFH@201174|Actinobacteria,4E0MB@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_1201736_19	1097668.BYI23_A013690	7.362e-08	66.0	COG0477@1|root,COG2814@2|Bacteria,1MWKH@1224|Proteobacteria,2VH75@28216|Betaproteobacteria,1JZTM@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_1201736_1	1229780.BN381_210109	3.459e-202	665.0	COG0320@1|root,COG0320@2|Bacteria,2GKD4@201174|Actinobacteria,3UWD6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
TLS2_k127_1201736_4	1121877.JQKF01000001_gene1338	1.653e-136	456.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4CMW0@84992|Acidimicrobiia	84992|Acidimicrobiia	C	e3 binding domain	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_1201736_2	1229780.BN381_210107	3.666e-198	628.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,3UWCV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_1201736_13	1283299.AUKG01000001_gene2598	2.952e-50	202.0	COG1305@1|root,COG1305@2|Bacteria,2GN5D@201174|Actinobacteria,4CPA0@84995|Rubrobacteria	84995|Rubrobacteria	E	Bacterial transglutaminase-like N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
TLS2_k127_1201736_10	36809.MAB_1636	1.396e-58	216.0	COG2307@1|root,COG2307@2|Bacteria,2GN0T@201174|Actinobacteria,234N2@1762|Mycobacteriaceae	201174|Actinobacteria	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
TLS2_k127_1201736_8	575540.Isop_2267	2.791e-78	268.0	COG2308@1|root,COG2308@2|Bacteria,2IXE6@203682|Planctomycetes	203682|Planctomycetes	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
TLS2_k127_1210091_1	1229780.BN381_10192	1.572e-92	331.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,3UWUN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
TLS2_k127_1210091_2	1313172.YM304_28540	2.308e-46	172.0	COG0526@1|root,COG0526@2|Bacteria,2H7FG@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1210091_0	525909.Afer_1606	3.576e-241	762.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4CMRD@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TLS2_k127_1215778_2	1229780.BN381_150043	7.045e-156	498.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,3UWCM@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Thiolase, C-terminal domain	fadA4	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0044464,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0075136,GO:1901575	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_1215778_1	1313172.YM304_37120	8.117e-212	665.0	COG0604@1|root,COG0604@2|Bacteria,2GKFF@201174|Actinobacteria,4CMSB@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Zinc-binding dehydrogenase	-	-	1.3.1.86	ko:K17829	ko00650,ko01120,ko01130,ko01200,map00650,map01120,map01130,map01200	-	R09738	RC00076	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_1215778_14	1229780.BN381_150047	6.967e-60	209.0	COG0346@1|root,COG0346@2|Bacteria,2IIPR@201174|Actinobacteria,3UWVQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Glyoxalase-like domain	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
TLS2_k127_1215778_15	1313172.YM304_17150	1.121e-58	212.0	COG2128@1|root,COG2128@2|Bacteria,2IS0M@201174|Actinobacteria	201174|Actinobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_1215778_16	1120948.KB903217_gene1163	3.504e-52	205.0	COG2199@1|root,COG3706@2|Bacteria,2I412@201174|Actinobacteria,4EDSF@85010|Pseudonocardiales	201174|Actinobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
TLS2_k127_1215778_11	1128421.JAGA01000003_gene3541	5.651e-67	244.0	COG1649@1|root,COG3391@1|root,COG1649@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	MA20_20600	-	1.14.17.3,2.7.11.1	ko:K00504,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	GHL10,NHL,Pkinase,SGL
TLS2_k127_1215778_30	926562.Oweho_0994	1.883e-07	63.0	2ENVG@1|root,33GGJ@2|Bacteria,4P2K9@976|Bacteroidetes,1I8MZ@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1215778_19	1110697.NCAST_23_00160	3.757e-40	168.0	2C56P@1|root,2ZJ2W@2|Bacteria,2IKDI@201174|Actinobacteria,4G0AJ@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1215778_20	1206737.BAGF01000046_gene2888	5.754e-37	156.0	2C56P@1|root,2ZJ2W@2|Bacteria,2IKDI@201174|Actinobacteria,4G0AJ@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1215778_21	1313172.YM304_31800	2.659e-34	136.0	COG2010@1|root,COG2010@2|Bacteria,2H614@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS2_k127_1215778_25	448385.sce8824	4.147e-27	121.0	COG1832@1|root,COG1832@2|Bacteria,1NJW8@1224|Proteobacteria,42WY1@68525|delta/epsilon subdivisions,2WT3S@28221|Deltaproteobacteria,2Z10K@29|Myxococcales	28221|Deltaproteobacteria	S	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2
TLS2_k127_1215778_12	1380390.JIAT01000010_gene4041	1.522e-61	226.0	COG2199@1|root,COG3706@2|Bacteria,2HFRX@201174|Actinobacteria,4CS9M@84995|Rubrobacteria	84995|Rubrobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
TLS2_k127_1215778_23	196162.Noca_0227	9.888e-31	123.0	2C0YF@1|root,2ZQ9N@2|Bacteria,2HAUG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1215778_5	196162.Noca_0228	4.375e-130	421.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_1215778_9	196162.Noca_0229	2.261e-88	307.0	COG2080@1|root,COG2080@2|Bacteria,2GMYH@201174|Actinobacteria,4DQP4@85009|Propionibacteriales	201174|Actinobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_1215778_0	196162.Noca_0230	0.0	1483.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_1215778_7	196162.Noca_0231	3.324e-101	351.0	COG1975@1|root,COG3350@1|root,COG1975@2|Bacteria,COG3350@2|Bacteria,2IA9U@201174|Actinobacteria,4DUZB@85009|Propionibacteriales	201174|Actinobacteria	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
TLS2_k127_1215778_10	196162.Noca_0232	1.179e-68	244.0	COG3427@1|root,COG3427@2|Bacteria,2GKTQ@201174|Actinobacteria,4DQ8Y@85009|Propionibacteriales	201174|Actinobacteria	S	Carbon monoxide dehydrogenase subunit G (CoxG)	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
TLS2_k127_1215778_24	675635.Psed_2650	2.205e-29	119.0	2FHR5@1|root,349IN@2|Bacteria,2H7DG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1215778_27	196162.Noca_0234	7.041e-21	98.0	28UY8@1|root,2ZH20@2|Bacteria,2HE0H@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1215778_22	196162.Noca_0235	1.377e-31	130.0	2922A@1|root,2ZPMG@2|Bacteria,2HB5Y@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1215778_18	196162.Noca_0236	1.059e-42	164.0	2FCSE@1|root,344VG@2|Bacteria,2H7G6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1215778_13	196162.Noca_0237	6.452e-61	218.0	arCOG08693@1|root,339YK@2|Bacteria,2H5DJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1215778_6	196162.Noca_0238	1.497e-125	413.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4DP1T@85009|Propionibacteriales	201174|Actinobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS2_k127_1215778_4	196162.Noca_0239	5.971e-131	428.0	COG0714@1|root,COG0714@2|Bacteria,2HQQ3@201174|Actinobacteria,4DVVI@85009|Propionibacteriales	201174|Actinobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
TLS2_k127_1215778_17	1283283.ATXA01000001_gene713	1.131e-45	177.0	COG1975@1|root,COG1975@2|Bacteria,2I8ZS@201174|Actinobacteria	201174|Actinobacteria	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS2_k127_1215778_8	926566.Terro_4363	1.529e-97	334.0	COG0258@1|root,COG0258@2|Bacteria,3Y2FG@57723|Acidobacteria,2JME1@204432|Acidobacteriia	204432|Acidobacteriia	L	Helix-hairpin-helix class 2 (Pol1 family) motifs	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
TLS2_k127_1215778_3	469383.Cwoe_3833	5.584e-135	437.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4CS2X@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA primase, small subunit	-	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
TLS2_k127_1215778_31	29581.BW37_05057	8.845e-06	55.0	COG4961@1|root,COG4961@2|Bacteria,1PWY9@1224|Proteobacteria,2WCG5@28216|Betaproteobacteria,477J5@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS2_k127_1258320_12	1184609.KILIM_004_00570	2.417e-48	190.0	COG0262@1|root,COG0262@2|Bacteria,2IM1S@201174|Actinobacteria,4F74K@85018|Dermatophilaceae	201174|Actinobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1,NUDIX
TLS2_k127_1258320_1	1449065.JMLL01000011_gene2487	2.27e-120	405.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2TQSB@28211|Alphaproteobacteria,43GVJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
TLS2_k127_1258320_5	1313172.YM304_27710	3.454e-95	332.0	COG0796@1|root,COG0796@2|Bacteria,2GN4I@201174|Actinobacteria,4CN3V@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
TLS2_k127_1258320_2	1313172.YM304_27700	8.473e-104	351.0	COG0689@1|root,COG0689@2|Bacteria,2GJFI@201174|Actinobacteria,4CMXE@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
TLS2_k127_1258320_13	1313172.YM304_27690	1.362e-47	188.0	COG0127@1|root,COG0127@2|Bacteria,2GM2B@201174|Actinobacteria,4CNBV@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
TLS2_k127_1258320_10	570268.ANBB01000035_gene2355	1.207e-56	209.0	COG0221@1|root,COG0221@2|Bacteria,2GM7F@201174|Actinobacteria,4EHYC@85012|Streptosporangiales	201174|Actinobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3628	Pyrophosphatase
TLS2_k127_1258320_15	936375.HMPREF1152_1094	2.048e-29	122.0	COG1970@1|root,COG1970@2|Bacteria,1VA14@1239|Firmicutes,24JAB@186801|Clostridia,3WCNU@538999|Clostridiales incertae sedis	186801|Clostridia	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
TLS2_k127_1258320_11	1229780.BN381_130090	1.973e-54	211.0	COG0477@1|root,COG2814@2|Bacteria,2GKRT@201174|Actinobacteria,3UXIH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_1258320_8	1229780.BN381_80062	1.523e-82	284.0	COG0740@1|root,COG0740@2|Bacteria,2GK5C@201174|Actinobacteria,3UWHQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TLS2_k127_1258320_16	266940.Krad_0131	2.308e-16	85.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP
TLS2_k127_1258320_4	1229780.BN381_80063	1.943e-102	339.0	COG0036@1|root,COG0036@2|Bacteria,2GJZ9@201174|Actinobacteria,3UWJU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TLS2_k127_1258320_6	1229780.BN381_80064	1.529e-90	312.0	COG2265@1|root,COG2265@2|Bacteria,2GIR3@201174|Actinobacteria,3UWPY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
TLS2_k127_1258320_3	1123320.KB889669_gene3247	1.147e-103	348.0	COG3173@1|root,COG3173@2|Bacteria,2GJT0@201174|Actinobacteria	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_1258320_9	457425.XNR_2891	1.355e-76	258.0	COG0748@1|root,COG0748@2|Bacteria,2HDJB@201174|Actinobacteria	201174|Actinobacteria	P	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_1258320_0	67373.JOBF01000012_gene3990	3.087e-130	439.0	COG1960@1|root,COG1960@2|Bacteria,2GJDT@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_1258320_7	1370121.AUWS01000044_gene1220	2.669e-84	297.0	COG4552@1|root,COG4552@2|Bacteria,2GNXZ@201174|Actinobacteria,234E7@1762|Mycobacteriaceae	201174|Actinobacteria	S	N-acetyltransferase Eis	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
TLS2_k127_1258320_14	397278.JOJN01000012_gene2181	9.971e-44	165.0	COG0438@1|root,COG0438@2|Bacteria,2GIW2@201174|Actinobacteria,4DTPV@85009|Propionibacteriales	201174|Actinobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4
TLS2_k127_1262685_4	1229780.BN381_290130	2.62e-46	169.0	COG0292@1|root,COG0292@2|Bacteria,2IHTN@201174|Actinobacteria,3UWMY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
TLS2_k127_1262685_7	1120950.KB892768_gene5218	4.201e-17	83.0	COG0291@1|root,COG0291@2|Bacteria,2GQZW@201174|Actinobacteria,4DSQQ@85009|Propionibacteriales	201174|Actinobacteria	J	Ribosomal protein L35	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
TLS2_k127_1262685_2	1229780.BN381_290132	9.322e-70	241.0	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,3UWKU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
TLS2_k127_1262685_5	1229780.BN381_290134	2.523e-26	121.0	2FH85@1|root,3492H@2|Bacteria,2H8HQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1262685_1	298654.FraEuI1c_4032	2.57e-78	286.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4EVAJ@85013|Frankiales	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_1262685_0	656024.FsymDg_3866	1.028e-94	320.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4ES7T@85013|Frankiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_1262685_3	1235279.C772_00367	2.547e-54	198.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,4HFRA@91061|Bacilli,26EVD@186818|Planococcaceae	91061|Bacilli	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08940	DMRL_synthase
TLS2_k127_1262685_6	1223542.GM1_010_00790	2.505e-20	92.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GIWJ@201174|Actinobacteria,4GC7A@85026|Gordoniaceae	201174|Actinobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	GO:0005575,GO:0005576,GO:0008150,GO:0040007	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1415	DHBP_synthase,GTP_cyclohydro2
TLS2_k127_1311529_17	1313172.YM304_22590	2.702e-53	198.0	COG0454@1|root,COG0456@2|Bacteria,2GM35@201174|Actinobacteria,4CN0X@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol	mshD	-	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
TLS2_k127_1311529_16	1313172.YM304_13100	5.165e-61	218.0	COG1814@1|root,COG1814@2|Bacteria,2GIZ3@201174|Actinobacteria,4CMZV@84992|Acidimicrobiia	84992|Acidimicrobiia	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
TLS2_k127_1311529_4	1313172.YM304_22570	1.267e-138	449.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4CMPY@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
TLS2_k127_1311529_18	1306174.JODP01000006_gene3644	3.886e-51	190.0	COG1208@1|root,COG1208@2|Bacteria,2IEN7@201174|Actinobacteria	201174|Actinobacteria	JM	Nucleotidyl transferase	-	-	2.7.7.13,2.7.7.99	ko:K00966,ko:K00992	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885,R11025	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_3,NTP_transferase
TLS2_k127_1311529_3	1278073.MYSTI_04820	3.858e-147	482.0	COG0318@1|root,COG0318@2|Bacteria,1MVJ1@1224|Proteobacteria	1224|Proteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.42	ko:K00666,ko:K18688	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_1311529_1	2002.JOEQ01000003_gene2374	1.419e-186	593.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4EHPJ@85012|Streptosporangiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_1311529_8	1313172.YM304_24030	1.218e-93	314.0	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4CN6D@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS2_k127_1311529_7	1313172.YM304_24020	6.714e-96	331.0	COG1169@1|root,COG1169@2|Bacteria,2GKE8@201174|Actinobacteria,4CNAM@84992|Acidimicrobiia	84992|Acidimicrobiia	HQ	chorismate binding enzyme	-	-	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
TLS2_k127_1311529_2	1343740.M271_03650	6.255e-158	529.0	COG1165@1|root,COG1165@2|Bacteria,2GMEB@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
TLS2_k127_1311529_12	1192034.CAP_1582	5.164e-81	279.0	COG2267@1|root,COG2267@2|Bacteria,1QUFU@1224|Proteobacteria,43BQ1@68525|delta/epsilon subdivisions,2X718@28221|Deltaproteobacteria,2Z3MK@29|Myxococcales	28221|Deltaproteobacteria	I	alpha/beta hydrolase fold	menH	-	4.2.99.20	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08166	RC02148,RC02475	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_6
TLS2_k127_1311529_11	1313172.YM304_23980	1.226e-81	284.0	COG1575@1|root,COG1575@2|Bacteria,2GJBS@201174|Actinobacteria,4CN0D@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TLS2_k127_1311529_6	1229780.BN381_430061	2.263e-115	386.0	COG0318@1|root,COG0318@2|Bacteria,2GN9C@201174|Actinobacteria,3UWTY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	IQ	AMP-binding enzyme	menE	GO:0003674,GO:0003824,GO:0008150,GO:0008756,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0040007	4.2.1.113,6.2.1.26	ko:K01911,ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030,R04031	RC00004,RC00014,RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_1311529_10	298655.KI912266_gene419	2.388e-84	293.0	COG1028@1|root,COG1028@2|Bacteria,2GMG3@201174|Actinobacteria,4ERGA@85013|Frankiales	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_1311529_14	1313172.YM304_19640	7.215e-65	229.0	COG0778@1|root,COG0778@2|Bacteria,2GW57@201174|Actinobacteria,4CN7W@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_1311529_21	1380347.JNII01000005_gene3183	4.571e-32	139.0	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria,4ET56@85013|Frankiales	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS2_k127_1311529_15	1313172.YM304_19630	9.355e-65	231.0	2BWZ3@1|root,33X4C@2|Bacteria,2H5EF@201174|Actinobacteria,4CN6H@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1311529_23	1476876.JOJO01000046_gene1322	7.236e-12	75.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
TLS2_k127_1311529_0	1229780.BN381_430072	0.0	1691.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,3UWBK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DNA polymerase alpha chain like domain	dnaE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS2_k127_1311529_19	1313172.YM304_19610	8.412e-49	179.0	291ZT@1|root,2ZPJ4@2|Bacteria,2GR7R@201174|Actinobacteria,4CN47@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF2587)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2587
TLS2_k127_1311529_5	1229780.BN381_430074	9.047e-133	434.0	COG1524@1|root,COG1524@2|Bacteria,2GISU@201174|Actinobacteria,3UWWP@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_1311529_13	1313172.YM304_19590	1.324e-65	233.0	COG1959@1|root,COG1959@2|Bacteria,2HG5V@201174|Actinobacteria,4CN2Q@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TLS2_k127_1311529_26	1220583.GOACH_04_05210	5.899e-08	65.0	COG1403@1|root,COG1403@2|Bacteria,2HAHI@201174|Actinobacteria,4GBH3@85026|Gordoniaceae	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_1311529_22	1298863.AUEP01000002_gene1456	5.805e-16	81.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4DQSY@85009|Propionibacteriales	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_1311529_9	1229780.BN381_430078	2.372e-84	289.0	COG0564@1|root,COG0564@2|Bacteria,2GIY1@201174|Actinobacteria,3UWB2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_1311529_20	1313172.YM304_19570	3.122e-40	156.0	COG0597@1|root,COG0597@2|Bacteria,2HGGT@201174|Actinobacteria,4CNE4@84992|Acidimicrobiia	84992|Acidimicrobiia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
TLS2_k127_1311529_25	1229780.BN381_430080	8.715e-12	65.0	COG1734@1|root,COG1734@2|Bacteria	2|Bacteria	T	zinc ion binding	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
TLS2_k127_1333524_0	1429046.RR21198_1180	6.774e-321	1009.0	COG0637@1|root,COG1554@1|root,COG1877@1|root,COG0637@2|Bacteria,COG1554@2|Bacteria,COG1877@2|Bacteria,2GKEV@201174|Actinobacteria,4FU49@85025|Nocardiaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 65, C-terminal domain	otsB1	GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0030312,GO:0044464,GO:0071944	3.2.1.28	ko:K01194	ko00500,ko01100,map00500,map01100	-	R00010	RC00049	ko00000,ko00001,ko00537,ko01000	-	GH37	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase,Trehalose_PPase
TLS2_k127_1333524_1	670292.JH26_06290	3.518e-190	601.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,1JTXY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	vraB	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_1333524_6	298655.KI912266_gene6084	2.556e-27	124.0	COG5401@1|root,COG5401@2|Bacteria,2H4HT@201174|Actinobacteria	201174|Actinobacteria	S	Immunoglobulin-like domain of bacterial spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
TLS2_k127_1333524_8	398578.Daci_4072	1.025e-07	63.0	COG3042@1|root,COG3042@2|Bacteria,1N8JF@1224|Proteobacteria,2VW4V@28216|Betaproteobacteria,4AFQI@80864|Comamonadaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF333)	-	-	-	ko:K09712	-	-	-	-	ko00000	-	-	-	DUF333
TLS2_k127_1333524_3	1206731.BAGB01000041_gene8421	8.306e-161	517.0	COG2230@1|root,COG2230@2|Bacteria,2GJ94@201174|Actinobacteria,4FWHU@85025|Nocardiaceae	201174|Actinobacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS2_k127_1333524_4	391625.PPSIR1_15585	1.196e-78	286.0	COG5285@1|root,COG5285@2|Bacteria,1R6VR@1224|Proteobacteria	1224|Proteobacteria	Q	Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin	cytC3	-	-	ko:K15650	-	-	-	-	ko00000,ko01008	-	-	-	PhyH
TLS2_k127_1333524_5	926550.CLDAP_11630	4.418e-39	159.0	COG2452@1|root,COG4936@1|root,COG2452@2|Bacteria,COG4936@2|Bacteria	2|Bacteria	KT	Sensory domain found in PocR	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HTH_17,PocR
TLS2_k127_1333524_2	1385519.N801_12760	1.715e-182	589.0	COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria,4FFV5@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DsrC,Pyr_redox_2
TLS2_k127_1333524_7	926550.CLDAP_11610	5.653e-25	117.0	COG2427@1|root,COG2427@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1641
TLS2_k127_1352015_6	1229780.BN381_80148	7.354e-52	190.0	COG1434@1|root,COG1434@2|Bacteria,2HPE7@201174|Actinobacteria,3UXHH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
TLS2_k127_1352015_1	1229780.BN381_80149	7.037e-152	493.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,3UW9W@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS2_k127_1352015_8	1313172.YM304_13050	1.39e-42	164.0	2F7CY@1|root,33ZTZ@2|Bacteria,2H76P@201174|Actinobacteria,4CNCM@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1352015_0	1313172.YM304_13020	1.117e-207	658.0	COG0119@1|root,COG0119@2|Bacteria,2GKYT@201174|Actinobacteria,4CMUV@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS2_k127_1352015_3	1313172.YM304_13000	1.415e-131	436.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4CMVG@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS2_k127_1352015_2	1229780.BN381_80141	5.047e-140	452.0	COG0473@1|root,COG0473@2|Bacteria,2GK44@201174|Actinobacteria,3UW6Z@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	CE	Isocitrate/isopropylmalate dehydrogenase	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_1352015_7	1229780.BN381_80140	7.781e-48	175.0	COG0782@1|root,COG0782@2|Bacteria,2GNZV@201174|Actinobacteria,3UWPU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0071944	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TLS2_k127_1352015_4	1313172.YM304_12960	1.035e-70	248.0	COG2267@1|root,COG2267@2|Bacteria,2I79Z@201174|Actinobacteria	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_1352015_5	1313172.YM304_12870	8.242e-62	222.0	COG1414@1|root,COG1414@2|Bacteria,2HGKQ@201174|Actinobacteria,4CP2Q@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS2_k127_1352015_9	1894.JOER01000020_gene3817	1.615e-20	91.0	COG0065@1|root,COG0065@2|Bacteria,2IC9D@201174|Actinobacteria	201174|Actinobacteria	E	Aconitase family (aconitate hydratase)	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TLS2_k127_1352255_7	365528.KB891159_gene5389	1.208e-31	129.0	COG1682@1|root,COG1682@2|Bacteria,2GP5K@201174|Actinobacteria,4ESU0@85013|Frankiales	201174|Actinobacteria	GM	Transport permease protein	wzm	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_1352255_0	1380354.JIAN01000001_gene3647	6.129e-99	343.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria	201174|Actinobacteria	GM	ABC transporter	rfbB2	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
TLS2_k127_1352255_10	1217720.ALOX01000027_gene3726	2.566e-06	61.0	COG2340@1|root,COG2340@2|Bacteria,1R2VW@1224|Proteobacteria,2TZSI@28211|Alphaproteobacteria	2|Bacteria	S	Domain of unknown function (DUF4214)	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CW_binding_2,Crystall,DUF4214,HemolysinCabind
TLS2_k127_1352255_6	1380356.JNIK01000016_gene3513	1.961e-41	175.0	COG5479@1|root,COG5479@2|Bacteria,2HYIN@201174|Actinobacteria,4EV8R@85013|Frankiales	201174|Actinobacteria	M	LGFP repeat	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,LGFP
TLS2_k127_1352255_2	1380393.JHVP01000002_gene1696	1.199e-74	277.0	COG1680@1|root,COG2385@1|root,COG1680@2|Bacteria,COG2385@2|Bacteria,2HEYF@201174|Actinobacteria,4ESKX@85013|Frankiales	201174|Actinobacteria	D	Stage II sporulation protein	-	-	-	-	-	-	-	-	-	-	-	-	SpoIID
TLS2_k127_1352255_8	1348114.OM33_05100	1.171e-19	104.0	COG2340@1|root,COG2931@1|root,COG4932@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1R245@1224|Proteobacteria,1T5GA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1352255_5	644282.Deba_0453	4.955e-44	178.0	COG2227@1|root,COG2227@2|Bacteria,1MZEB@1224|Proteobacteria,43E9B@68525|delta/epsilon subdivisions,2WQYA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM Methyltransferase domain	-	-	2.1.1.294,2.7.1.181	ko:K18827	-	-	R10657,R10658	RC00002,RC00003,RC00078,RC03220	ko00000,ko01000,ko01005	-	-	-	Methyltransf_11,Methyltransf_23
TLS2_k127_1352255_1	326427.Cagg_2454	4.363e-90	308.0	COG0438@1|root,COG0438@2|Bacteria,2G7XU@200795|Chloroflexi,3755Q@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
TLS2_k127_1352255_3	1384066.JAGT01000001_gene1746	6.318e-64	235.0	COG0438@1|root,COG0438@2|Bacteria,1UZ2J@1239|Firmicutes,24DGK@186801|Clostridia,3WI20@541000|Ruminococcaceae	186801|Clostridia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_1352255_4	1235835.C814_02338	6.278e-49	199.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_2
TLS2_k127_1352255_9	710696.Intca_0275	1.587e-15	78.0	COG2247@1|root,COG2247@2|Bacteria,2I4K0@201174|Actinobacteria,4FGIA@85021|Intrasporangiaceae	201174|Actinobacteria	M	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,CW_binding_2,VCBS
TLS2_k127_1352908_47	1229780.BN381_130092	3.018e-11	65.0	COG5282@1|root,COG5282@2|Bacteria,2GJ9K@201174|Actinobacteria,3UWII@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
TLS2_k127_1352908_25	1229780.BN381_130090	4.591e-85	301.0	COG0477@1|root,COG2814@2|Bacteria,2GKRT@201174|Actinobacteria,3UXIH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_1352908_19	1313172.YM304_07750	2.136e-100	331.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4CMYH@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_1352908_26	1229780.BN381_30043	1.875e-78	278.0	COG5002@1|root,COG5002@2|Bacteria,2GJY7@201174|Actinobacteria,3UWMA@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	phoR	-	2.7.13.3	ko:K07636,ko:K07768	ko02020,map02020	M00434,M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4
TLS2_k127_1352908_27	1229780.BN381_30044	1.712e-77	276.0	COG0704@1|root,COG0704@2|Bacteria,2GKAD@201174|Actinobacteria,3UWW3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TLS2_k127_1352908_44	273068.TTE1627	2.338e-19	97.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia,42FW2@68295|Thermoanaerobacterales	186801|Clostridia	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TLS2_k127_1352908_14	1205910.B005_1754	1.822e-119	391.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4EM3I@85012|Streptosporangiales	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TLS2_k127_1352908_22	446468.Ndas_5387	6.171e-92	311.0	COG0581@1|root,COG0581@2|Bacteria,2IBYS@201174|Actinobacteria,4EQUZ@85012|Streptosporangiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS2_k127_1352908_20	1246474.ANBE01000021_gene3965	8.934e-97	327.0	COG0573@1|root,COG0573@2|Bacteria,2IDRE@201174|Actinobacteria,4EQV0@85012|Streptosporangiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS2_k127_1352908_12	443218.AS9A_1202	5.876e-131	437.0	COG0226@1|root,COG0226@2|Bacteria,2HNK6@201174|Actinobacteria,23DHM@1762|Mycobacteriaceae	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
TLS2_k127_1352908_13	1463845.JOIG01000003_gene5100	7.557e-121	394.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	-	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TLS2_k127_1352908_33	2002.JOEQ01000006_gene1440	1.011e-49	196.0	COG0501@1|root,COG0501@2|Bacteria,2GRBS@201174|Actinobacteria,4EHKE@85012|Streptosporangiales	201174|Actinobacteria	O	CAAX prenyl protease N-terminal, five membrane helices	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
TLS2_k127_1352908_38	1173024.KI912149_gene5846	6.327e-32	129.0	COG0640@1|root,COG0640@2|Bacteria,1G7VI@1117|Cyanobacteria,1JM9G@1189|Stigonemataceae	1117|Cyanobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
TLS2_k127_1352908_32	710111.FraQA3DRAFT_1286	1.348e-51	187.0	COG0346@1|root,COG0346@2|Bacteria,2IFUM@201174|Actinobacteria,4EVK6@85013|Frankiales	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	cadI	GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_1352908_37	222534.KB893719_gene1067	7.638e-34	139.0	COG0494@1|root,COG0494@2|Bacteria,2GNRV@201174|Actinobacteria,4EXC2@85013|Frankiales	201174|Actinobacteria	GL	NUDIX domain	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
TLS2_k127_1352908_2	1229780.BN381_130089	2.344e-263	828.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria,3UWBN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
TLS2_k127_1352908_41	1313172.YM304_07670	2.628e-26	117.0	2FBA6@1|root,343GA@2|Bacteria,2H78Y@201174|Actinobacteria,4CN8Z@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1352908_40	1313172.YM304_07660	1.194e-27	115.0	2CC1Y@1|root,32TCV@2|Bacteria,2HGD4@201174|Actinobacteria,4CNAQ@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	-	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS2_k127_1352908_51	278957.ABEA03000195_gene543	3.183e-08	56.0	COG1826@1|root,COG1826@2|Bacteria,46WPX@74201|Verrucomicrobia,3K8HZ@414999|Opitutae	414999|Opitutae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS2_k127_1352908_52	278957.ABEA03000195_gene543	6.804e-08	55.0	COG1826@1|root,COG1826@2|Bacteria,46WPX@74201|Verrucomicrobia,3K8HZ@414999|Opitutae	414999|Opitutae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS2_k127_1352908_30	525909.Afer_0329	1.151e-71	251.0	COG3643@1|root,COG3643@2|Bacteria,2H8ZI@201174|Actinobacteria,4CNR1@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Formiminotransferase domain, N-terminal subdomain	-	-	2.1.2.5	ko:K00603	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R03189	RC00165,RC00221,RC00223,RC00870	ko00000,ko00001,ko01000	-	-	-	FTCD_N
TLS2_k127_1352908_36	1229780.BN381_130084	5.074e-39	148.0	2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,3UWSD@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whmD	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS2_k127_1352908_50	913848.AELK01000065_gene1320	1.776e-08	65.0	COG1835@1|root,COG1835@2|Bacteria,1TPTG@1239|Firmicutes,4HB7R@91061|Bacilli,3F3WT@33958|Lactobacillaceae	91061|Bacilli	I	Acyltransferase	oatA	GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS2_k127_1352908_1	1313172.YM304_07620	2.8e-287	896.0	COG4867@1|root,COG4867@2|Bacteria,2H14W@201174|Actinobacteria,4CMU5@84992|Acidimicrobiia	84992|Acidimicrobiia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1352908_4	1313172.YM304_07520	2.968e-218	689.0	COG1239@1|root,COG1239@2|Bacteria,2GMRS@201174|Actinobacteria,4CMSG@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Mg-chelatase subunit ChlI	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	-
TLS2_k127_1352908_6	1313172.YM304_07510	3.749e-188	612.0	COG3250@1|root,COG3250@2|Bacteria,2GM69@201174|Actinobacteria	201174|Actinobacteria	G	beta-mannosidase	csxA	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005576,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044238,GO:0071704,GO:1901575	3.2.1.165,3.2.1.25	ko:K01192,ko:K15855	ko00511,ko00520,ko01100,ko04142,map00511,map00520,map01100,map04142	-	R01966	RC00049	ko00000,ko00001,ko01000	-	-	-	F5_F8_type_C,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TLS2_k127_1352908_46	1122998.AUHZ01000026_gene36	4.482e-12	76.0	2B5R0@1|root,31YKI@2|Bacteria,2IPMA@201174|Actinobacteria,4DR93@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1352908_39	1032480.MLP_44000	9.918e-28	123.0	COG3877@1|root,COG3877@2|Bacteria,2IT3M@201174|Actinobacteria,4DVDP@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
TLS2_k127_1352908_21	298655.KI912266_gene2194	2.116e-94	319.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4EU25@85013|Frankiales	201174|Actinobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
TLS2_k127_1352908_11	479432.Sros_4171	2.47e-137	453.0	COG0654@1|root,COG0654@2|Bacteria,2I901@201174|Actinobacteria	201174|Actinobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAD_binding_2,NAD_binding_8,Trp_halogenase
TLS2_k127_1352908_29	1229780.BN381_130079	7.815e-72	253.0	28HIR@1|root,2Z7U4@2|Bacteria,2GN2S@201174|Actinobacteria,3UXG4@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS2_k127_1352908_0	153721.MYP_1448	1.003e-313	982.0	COG1053@1|root,COG1053@2|Bacteria,4NFDU@976|Bacteroidetes,47JE5@768503|Cytophagia	976|Bacteroidetes	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_1352908_16	1229780.BN381_130077	1.031e-110	387.0	COG0479@1|root,COG0479@2|Bacteria,2GJPS@201174|Actinobacteria	201174|Actinobacteria	C	succinate dehydrogenase	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
TLS2_k127_1352908_23	1313172.YM304_11550	5.719e-88	299.0	COG2035@1|root,COG2035@2|Bacteria,2I8HU@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	ko:K08974	-	-	-	-	ko00000	-	-	-	DUF368
TLS2_k127_1352908_15	526225.Gobs_2962	2.713e-115	388.0	COG3004@1|root,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria	201174|Actinobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
TLS2_k127_1352908_45	1229780.BN381_130073	7.11e-19	98.0	COG3173@1|root,COG3173@2|Bacteria,2GMZQ@201174|Actinobacteria	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	EcKinase
TLS2_k127_1352908_28	1048339.KB913029_gene580	2.007e-75	264.0	COG3662@1|root,COG3662@2|Bacteria,2GJD2@201174|Actinobacteria,4ESC5@85013|Frankiales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
TLS2_k127_1352908_48	67257.JODR01000017_gene4447	1.446e-09	66.0	COG1714@1|root,COG1714@2|Bacteria,2GN0D@201174|Actinobacteria	201174|Actinobacteria	UW	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,RDD
TLS2_k127_1352908_24	1313172.YM304_07320	2.639e-86	311.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the FPG family	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_1352908_34	1380347.JNII01000006_gene1617	4.892e-43	171.0	COG1819@1|root,COG1819@2|Bacteria,2GJN7@201174|Actinobacteria	201174|Actinobacteria	CG	Glycosyltransferase, MGT family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,UDPGT
TLS2_k127_1352908_9	937777.Deipe_0633	9.313e-154	506.0	COG0039@1|root,COG0039@2|Bacteria,1WJHY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
TLS2_k127_1352908_10	1123023.JIAI01000001_gene7612	1.992e-145	472.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4E0JB@85010|Pseudonocardiales	201174|Actinobacteria	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_1352908_35	1122221.JHVI01000008_gene2290	2.376e-42	166.0	COG2320@1|root,COG2320@2|Bacteria,1WMTH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	GrpB protein	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
TLS2_k127_1352908_43	110319.CF8_2112	5.837e-21	103.0	COG1917@1|root,COG1917@2|Bacteria,2GYT0@201174|Actinobacteria	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_1352908_5	1229780.BN381_130069	2.575e-196	647.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,3UX2M@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	V	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K02021,ko:K06147,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_membrane,ABC_tran
TLS2_k127_1352908_8	471852.Tcur_2881	7.016e-159	521.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EG83@85012|Streptosporangiales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
TLS2_k127_1352908_3	1463845.JOIG01000003_gene4890	2.565e-233	729.0	COG0538@1|root,COG0538@2|Bacteria,2GM3D@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the isocitrate and isopropylmalate dehydrogenases family	icd	GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_1352908_18	1229780.BN381_130064	2.299e-102	355.0	COG0685@1|root,COG0685@2|Bacteria,2GJTN@201174|Actinobacteria,3UWKR@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS2_k127_1352908_17	1229780.BN381_130063	3.621e-109	370.0	COG0190@1|root,COG0190@2|Bacteria,2GJZS@201174|Actinobacteria,3UWCI@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
TLS2_k127_1352908_49	1463854.JOHT01000008_gene5704	1.83e-09	67.0	COG1714@1|root,COG1714@2|Bacteria,2GN0D@201174|Actinobacteria	201174|Actinobacteria	UW	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,RDD
TLS2_k127_1352908_53	711393.AYRX01000008_gene4351	1.602e-07	63.0	COG1714@1|root,COG1714@2|Bacteria,2HGSH@201174|Actinobacteria	201174|Actinobacteria	S	RDD domain containing protein	pra	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	RDD
TLS2_k127_1352908_7	649638.Trad_0076	8.294e-169	550.0	COG0138@1|root,COG0138@2|Bacteria,1WIVC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
TLS2_k127_1352908_31	1229780.BN381_130059	2.835e-61	216.0	COG0299@1|root,COG0299@2|Bacteria,2H8QB@201174|Actinobacteria,3UWRP@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
TLS2_k127_1353545_1	408672.NBCG_01838	3.112e-222	709.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4DPKK@85009|Propionibacteriales	201174|Actinobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS2_k127_1353545_4	1068978.AMETH_0144	4.334e-123	400.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4E1TV@85010|Pseudonocardiales	201174|Actinobacteria	E	pfam abc	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_1353545_6	408672.NBCG_01840	6.66e-105	352.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4DPMH@85009|Propionibacteriales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_1353545_2	1229780.BN381_40056	6.693e-215	685.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,3UX28@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	fadE1_1	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_1353545_9	1123258.AQXZ01000017_gene4359	2.164e-64	227.0	COG1309@1|root,COG1309@2|Bacteria,2GJ7G@201174|Actinobacteria	201174|Actinobacteria	K	Regulatory protein tetr	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_1353545_5	1313172.YM304_22670	3.563e-114	395.0	COG0667@1|root,COG0667@2|Bacteria,2GMT5@201174|Actinobacteria,4CMWV@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_1353545_0	330084.JNYZ01000048_gene2978	1.169e-291	925.0	COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,4E9V6@85010|Pseudonocardiales	201174|Actinobacteria	KL	SNF2 Helicase protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
TLS2_k127_1353545_8	479435.Kfla_4669	5.535e-85	306.0	COG4279@1|root,COG4279@2|Bacteria,2GIYW@201174|Actinobacteria,4DU1P@85009|Propionibacteriales	201174|Actinobacteria	S	SWIM zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
TLS2_k127_1353545_7	1120950.KB892819_gene7146	1.554e-93	314.0	COG1357@1|root,COG1357@2|Bacteria,2GN74@201174|Actinobacteria,4DN7S@85009|Propionibacteriales	201174|Actinobacteria	S	Pentapeptide repeats (8 copies)	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,Pentapeptide,Pentapeptide_4
TLS2_k127_1353545_11	644283.Micau_1843	4.494e-11	75.0	COG2334@1|root,COG2334@2|Bacteria,2GXZI@201174|Actinobacteria,4DG27@85008|Micromonosporales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_1353545_3	593907.Celgi_2993	2.572e-131	432.0	COG0738@1|root,COG0738@2|Bacteria,2GRCY@201174|Actinobacteria	201174|Actinobacteria	G	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_1353545_10	590998.Celf_1110	1.948e-14	77.0	COG0572@1|root,COG0572@2|Bacteria,2GMCP@201174|Actinobacteria	201174|Actinobacteria	F	PFAM AIG2 family protein	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
TLS2_k127_1369527_0	1121877.JQKF01000016_gene120	3.573e-126	422.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4CMW1@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
TLS2_k127_1369527_1	1313172.YM304_05090	3.824e-55	218.0	COG3599@1|root,COG3599@2|Bacteria	2|Bacteria	D	regulation of cell shape	-	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
TLS2_k127_1369527_2	1137271.AZUM01000005_gene312	2.434e-50	194.0	COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria,4DYAZ@85010|Pseudonocardiales	201174|Actinobacteria	T	Belongs to the peptidase S16 family	lon	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
TLS2_k127_1376887_0	1123501.KB902310_gene60	1.823e-291	902.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	bhbA	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
TLS2_k127_1376887_1	414684.RC1_3097	2.439e-117	386.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2TS96@28211|Alphaproteobacteria,2JP84@204441|Rhodospirillales	204441|Rhodospirillales	E	periplasmic protein kinase ArgK and related GTPases of G3E family	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS2_k127_1376887_3	225400.XP_006769816.1	2.08e-28	133.0	COG5640@1|root,KOG3627@2759|Eukaryota,39RFD@33154|Opisthokonta,3B9SA@33208|Metazoa,3CVMP@33213|Bilateria,48556@7711|Chordata,49608@7742|Vertebrata,3J3UK@40674|Mammalia,4KU2P@9397|Chiroptera	33208|Metazoa	O	Belongs to the peptidase S1 family	CTRL	GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005615,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0043170,GO:0044238,GO:0044421,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K09632	ko04972,ko04974,map04972,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Trypsin
TLS2_k127_1376887_2	1123251.ATWM01000007_gene2365	1.83e-31	143.0	COG1404@1|root,COG2385@1|root,COG3055@1|root,COG1404@2|Bacteria,COG2385@2|Bacteria,COG3055@2|Bacteria,2I7DE@201174|Actinobacteria,4FFA3@85021|Intrasporangiaceae	201174|Actinobacteria	O	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,CarboxypepD_reg,Kelch_1,Malectin,Peptidase_S8
TLS2_k127_1377422_5	525909.Afer_0790	7.795e-55	199.0	COG1057@1|root,COG1057@2|Bacteria,2GMFZ@201174|Actinobacteria,4CN49@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_1377422_4	1313172.YM304_26770	2.387e-111	367.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CMST@84992|Acidimicrobiia	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Helicase_C,ResIII,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_1377422_1	1313172.YM304_26780	9.33e-215	676.0	COG3200@1|root,COG3200@2|Bacteria,2GJBX@201174|Actinobacteria,4CMTE@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Class-II DAHP synthetase family	-	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
TLS2_k127_1377422_7	590998.Celf_3363	6.837e-29	131.0	COG5343@1|root,COG5343@2|Bacteria,2IM7X@201174|Actinobacteria,4F2HP@85016|Cellulomonadaceae	201174|Actinobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
TLS2_k127_1377422_6	1246995.AFR_20885	1.098e-45	175.0	COG1595@1|root,COG1595@2|Bacteria,2IKQ7@201174|Actinobacteria,4DAY0@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	litS	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_1377422_0	1313172.YM304_23520	1.465e-225	718.0	COG3552@1|root,COG3825@1|root,COG3552@2|Bacteria,COG3825@2|Bacteria,2GNTS@201174|Actinobacteria,4CMU1@84992|Acidimicrobiia	84992|Acidimicrobiia	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS2_k127_1377422_2	1229780.BN381_10219	9.401e-141	451.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,3UX3U@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
TLS2_k127_1377422_8	1068980.ARVW01000001_gene7046	2.15e-19	102.0	COG1680@1|root,COG1680@2|Bacteria,2GK3A@201174|Actinobacteria,4E9NU@85010|Pseudonocardiales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_1377422_3	663278.Ethha_0138	3.422e-140	464.0	COG0014@1|root,COG0014@2|Bacteria,1TQ9V@1239|Firmicutes,248NX@186801|Clostridia,3WH60@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_1377422_9	1229780.BN381_10211	5.543e-17	91.0	2CIFA@1|root,348QY@2|Bacteria,2H88E@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1383774_2	1229780.BN381_80362	3.701e-131	436.0	COG0141@1|root,COG0141@2|Bacteria,2GKKA@201174|Actinobacteria,3UWFF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
TLS2_k127_1383774_1	1313172.YM304_22610	1.79e-138	452.0	COG0079@1|root,COG0079@2|Bacteria,2GJ9W@201174|Actinobacteria,4CMYU@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_1383774_4	1313172.YM304_22620	1.103e-79	281.0	COG0131@1|root,COG0131@2|Bacteria,2GKMD@201174|Actinobacteria,4CN2F@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
TLS2_k127_1383774_5	1229780.BN381_80369	3.758e-70	246.0	COG0118@1|root,COG0118@2|Bacteria,2GIYS@201174|Actinobacteria,3UWJ0@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS2_k127_1383774_7	1313172.YM304_22640	1.983e-57	213.0	COG0106@1|root,COG0106@2|Bacteria,2GJ4V@201174|Actinobacteria,4CNA5@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Histidine biosynthesis protein	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS2_k127_1383774_3	1313172.YM304_22650	5.569e-118	392.0	COG0107@1|root,COG0107@2|Bacteria,2GIRP@201174|Actinobacteria,4CMXG@84992|Acidimicrobiia	84992|Acidimicrobiia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS2_k127_1383774_12	1313172.YM304_22680	1.118e-36	150.0	COG2945@1|root,COG2945@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4
TLS2_k127_1383774_9	479435.Kfla_1859	5.569e-41	158.0	COG0234@1|root,COG0234@2|Bacteria,2IHRC@201174|Actinobacteria,4DR8F@85009|Propionibacteriales	201174|Actinobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groES2	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TLS2_k127_1383774_6	37919.EP51_10295	6.495e-59	208.0	COG2318@1|root,COG2318@2|Bacteria,2IGJQ@201174|Actinobacteria	201174|Actinobacteria	H	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
TLS2_k127_1383774_11	1313172.YM304_22700	1.361e-37	153.0	COG0139@1|root,COG0139@2|Bacteria,2IKKU@201174|Actinobacteria,4CN95@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
TLS2_k127_1383774_0	1313172.YM304_22710	1.65e-212	674.0	COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4CMW2@84992|Acidimicrobiia	84992|Acidimicrobiia	EH	Anthranilate synthase component I, N terminal region	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS2_k127_1383774_8	1229780.BN381_80382	9.161e-51	191.0	COG0354@1|root,COG0354@2|Bacteria,2GKP0@201174|Actinobacteria,3UX0E@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Belongs to the GcvT family	ygfZ	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
TLS2_k127_1383774_10	596151.DesfrDRAFT_0282	4.376e-38	166.0	2AD1R@1|root,312PX@2|Bacteria,1QCNM@1224|Proteobacteria,433DK@68525|delta/epsilon subdivisions,2WY1V@28221|Deltaproteobacteria,2M8UB@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
TLS2_k127_143895_11	649831.L083_2002	1.91e-33	135.0	COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria,4DB3A@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TLS2_k127_143895_3	1313172.YM304_24990	1.918e-112	373.0	COG0287@1|root,COG0287@2|Bacteria,2GKB4@201174|Actinobacteria,4CNBS@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K00210,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
TLS2_k127_143895_5	1313172.YM304_24980	5.298e-96	319.0	COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,4CN36@84992|Acidimicrobiia	84992|Acidimicrobiia	J	RNA pseudouridylate synthase	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_143895_8	1313172.YM304_24970	4.402e-66	243.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,4CN9J@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
TLS2_k127_143895_6	1229780.BN381_290072	2.208e-95	318.0	COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria,3UWJ9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
TLS2_k127_143895_1	521098.Aaci_1563	2.151e-139	450.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,4H9U5@91061|Bacilli,2782C@186823|Alicyclobacillaceae	91061|Bacilli	M	RmlD substrate binding domain	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_143895_2	1382304.JNIL01000001_gene1595	9.578e-116	381.0	COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,4HA1K@91061|Bacilli,2781H@186823|Alicyclobacillaceae	91061|Bacilli	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS2_k127_143895_13	1235279.C772_02318	7.929e-14	75.0	COG1734@1|root,COG1734@2|Bacteria,1V4KF@1239|Firmicutes,4HHBC@91061|Bacilli,26I4S@186818|Planococcaceae	91061|Bacilli	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
TLS2_k127_143895_4	1313172.YM304_24920	1.756e-104	348.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CMZU@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Phage integrase, N-terminal SAM-like domain	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_143895_9	1313172.YM304_24910	1.286e-36	157.0	COG0494@1|root,COG0494@2|Bacteria,2GNW6@201174|Actinobacteria,4CNBA@84992|Acidimicrobiia	84992|Acidimicrobiia	L	NUDIX domain	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TLS2_k127_143895_0	1313172.YM304_24900	2.007e-269	837.0	COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria,4CMQD@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
TLS2_k127_143895_10	1246448.ANAZ01000023_gene2120	3.771e-35	154.0	COG0472@1|root,COG0472@2|Bacteria,2HS8K@201174|Actinobacteria,4EG6C@85012|Streptosporangiales	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_143895_7	1229780.BN381_290084	6.716e-92	334.0	COG1215@1|root,COG3119@1|root,COG1215@2|Bacteria,COG3119@2|Bacteria,2H59R@201174|Actinobacteria	201174|Actinobacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1504720_1	1038860.AXAP01000001_gene6616	4.09e-53	193.0	COG0596@1|root,COG0596@2|Bacteria,1N5ZI@1224|Proteobacteria,2TS7X@28211|Alphaproteobacteria,3JT68@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	ephA	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_1504720_0	392499.Swit_3100	1.835e-118	397.0	COG1520@1|root,COG1520@2|Bacteria,1R4I1@1224|Proteobacteria,2U05B@28211|Alphaproteobacteria,2K9NV@204457|Sphingomonadales	204457|Sphingomonadales	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1504720_4	2045.KR76_05190	3.017e-11	76.0	2C2K7@1|root,342A4@2|Bacteria,2IS1R@201174|Actinobacteria,4DT9B@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1504720_2	593907.Celgi_0934	1.106e-47	180.0	COG0039@1|root,COG0039@2|Bacteria,2GJHS@201174|Actinobacteria,4F1TY@85016|Cellulomonadaceae	201174|Actinobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0030312,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
TLS2_k127_1504720_3	1463901.JOIY01000031_gene3290	5.693e-13	78.0	2ES34@1|root,33JN0@2|Bacteria,2GKCH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1532438_21	591158.SSMG_01599	2.603e-39	164.0	COG2197@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria	201174|Actinobacteria	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HD_5
TLS2_k127_1532438_0	1313172.YM304_33630	0.0	1767.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1,Thiol-ester_cl
TLS2_k127_1532438_18	675635.Psed_1168	2.966e-62	226.0	COG4221@1|root,COG4221@2|Bacteria,2GN3I@201174|Actinobacteria,4E5Y9@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_1532438_17	1169152.AXVD01000023_gene3256	1.094e-64	233.0	COG2021@1|root,COG2021@2|Bacteria,2HIEG@201174|Actinobacteria,4G3VG@85025|Nocardiaceae	201174|Actinobacteria	E	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_1532438_22	1123322.KB904658_gene1355	5.488e-39	153.0	COG1309@1|root,COG1309@2|Bacteria,2IKQ8@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_1532438_7	1223543.GP2_021_00160	3.289e-116	392.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4GCFF@85026|Gordoniaceae	201174|Actinobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
TLS2_k127_1532438_26	1242864.D187_000012	5.944e-11	73.0	COG5592@1|root,COG5592@2|Bacteria,1RI8J@1224|Proteobacteria,42XM7@68525|delta/epsilon subdivisions,2WSTY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS2_k127_1532438_1	1463864.JOGO01000019_gene1601	1.442e-255	808.0	COG0753@1|root,COG0753@2|Bacteria,2GITN@201174|Actinobacteria	201174|Actinobacteria	P	serves to protect cells from the toxic effects of hydrogen peroxide	katE	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
TLS2_k127_1532438_10	644283.Micau_0768	4.113e-102	342.0	COG1609@1|root,COG1609@2|Bacteria,2GJRG@201174|Actinobacteria,4DBCY@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator, LacI family	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	LacI,Peripla_BP_3
TLS2_k127_1532438_9	926550.CLDAP_04710	1.698e-103	361.0	COG2182@1|root,COG2182@2|Bacteria,2G91A@200795|Chloroflexi	200795|Chloroflexi	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K15770	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	SBP_bac_8
TLS2_k127_1532438_5	446470.Snas_5890	1.008e-127	425.0	COG1175@1|root,COG1175@2|Bacteria,2GJGB@201174|Actinobacteria,4EY5M@85014|Glycomycetales	201174|Actinobacteria	G	N-terminal of TM subunit in PBP-dependent ABC transporters	malF	-	-	ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1,TM_PBP2_N
TLS2_k127_1532438_8	1449044.JMLE01000013_gene2750	1.084e-103	361.0	COG3833@1|root,COG3833@2|Bacteria,2I2EZ@201174|Actinobacteria,1W8CM@1268|Micrococcaceae	201174|Actinobacteria	G	ABC transporter	-	-	-	ko:K15772	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
TLS2_k127_1532438_20	1157640.AQWO01000010_gene2903	7.548e-45	170.0	COG0346@1|root,COG0346@2|Bacteria,2IM1B@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_1532438_6	1313172.YM304_41460	1.832e-125	408.0	COG2354@1|root,COG2354@2|Bacteria,2GM9S@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	yedI	-	-	ko:K09781	-	-	-	-	ko00000	-	-	-	DUF808
TLS2_k127_1532438_15	675635.Psed_5537	9.661e-73	258.0	2A3AC@1|root,30RSD@2|Bacteria,2IKHP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1532438_19	1184609.KILIM_021_00240	1.083e-53	193.0	2BVHN@1|root,332R2@2|Bacteria,2IPM7@201174|Actinobacteria	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS2_k127_1532438_14	483219.LILAB_06300	2.849e-74	261.0	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,42R10@68525|delta/epsilon subdivisions,2WN3Z@28221|Deltaproteobacteria,2Z0C7@29|Myxococcales	28221|Deltaproteobacteria	L	NADH pyrophosphatase-like rudimentary NUDIX domain	nudC	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
TLS2_k127_1532438_12	1380347.JNII01000008_gene4162	3.135e-78	276.0	COG3173@1|root,COG3173@2|Bacteria,2GKUU@201174|Actinobacteria,4EUYM@85013|Frankiales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_1532438_4	1229780.BN381_70077	4.973e-137	465.0	COG1020@1|root,COG1020@2|Bacteria,2GKU0@201174|Actinobacteria	201174|Actinobacteria	Q	diacylglycerol O-acyltransferase	-	-	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
TLS2_k127_1532438_11	1440774.Y900_022215	5.89e-102	338.0	COG1234@1|root,COG1234@2|Bacteria,2HV83@201174|Actinobacteria,232BJ@1762|Mycobacteriaceae	201174|Actinobacteria	S	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
TLS2_k127_1532438_13	1229780.BN381_210048	1.056e-75	260.0	COG4430@1|root,COG4430@2|Bacteria,2II0D@201174|Actinobacteria,3UXQY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
TLS2_k127_1532438_30	337191.KTR9_4725	9.638e-07	58.0	COG5658@1|root,COG5658@2|Bacteria,2GR16@201174|Actinobacteria,4GE1E@85026|Gordoniaceae	201174|Actinobacteria	S	SdpI/YhfL protein family	-	-	-	-	-	-	-	-	-	-	-	-	SdpI
TLS2_k127_1532438_2	1313172.YM304_39870	2.756e-197	624.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,4CMVK@84992|Acidimicrobiia	84992|Acidimicrobiia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_1532438_23	1096546.WYO_5726	3.1e-20	98.0	COG1999@1|root,COG1999@2|Bacteria,1RHSV@1224|Proteobacteria	1224|Proteobacteria	S	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
TLS2_k127_1532438_24	670307.HYPDE_41668	3.565e-18	94.0	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2UBUR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Protein conserved in bacteria	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
TLS2_k127_1532438_29	324602.Caur_0565	8.032e-07	55.0	COG3794@1|root,COG3794@2|Bacteria,2GB9I@200795|Chloroflexi,377MB@32061|Chloroflexia	32061|Chloroflexia	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1532438_16	83406.HDN1F_37160	8.264e-66	252.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,Response_reg
TLS2_k127_1532438_25	1121933.AUHH01000035_gene130	3.918e-12	74.0	2EBIV@1|root,335JA@2|Bacteria,2IHZS@201174|Actinobacteria,4DRF2@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
TLS2_k127_1532438_3	512565.AMIS_46090	2.338e-174	560.0	COG2268@1|root,COG2268@2|Bacteria,2GK9I@201174|Actinobacteria,4D8CU@85008|Micromonosporales	201174|Actinobacteria	S	Flotillin	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
TLS2_k127_1532554_11	1229780.BN381_50075	3.752e-88	308.0	COG1572@1|root,COG1572@2|Bacteria,2I56C@201174|Actinobacteria,3UXIZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Domain of unknown function (DUF3367)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3367
TLS2_k127_1532554_1	106370.Francci3_1050	7.946e-303	981.0	COG1572@1|root,COG1572@2|Bacteria,2I56C@201174|Actinobacteria,4EXBH@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF3367)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3367
TLS2_k127_1532554_2	479433.Caci_8013	2.51e-229	719.0	COG1232@1|root,COG1232@2|Bacteria,2IDI5@201174|Actinobacteria	201174|Actinobacteria	H	PFAM amine oxidase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
TLS2_k127_1532554_12	1313172.YM304_25030	2.26e-72	252.0	COG4122@1|root,COG4122@2|Bacteria,2GQ0Z@201174|Actinobacteria	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
TLS2_k127_1532554_7	365528.KB891239_gene6045	2.211e-126	422.0	COG0438@1|root,COG0438@2|Bacteria,2GK8D@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_1532554_15	1229780.BN381_130352	1.061e-64	228.0	COG2267@1|root,COG2267@2|Bacteria,2IS9U@201174|Actinobacteria	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_1532554_8	222534.KB893756_gene4220	4.878e-106	368.0	COG1835@1|root,COG2755@1|root,COG1835@2|Bacteria,COG2755@2|Bacteria,2GKI5@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS2_k127_1532554_14	1313172.YM304_34920	1.217e-69	249.0	COG4502@1|root,COG4502@2|Bacteria,2IAHF@201174|Actinobacteria	201174|Actinobacteria	S	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)	-	-	-	-	-	-	-	-	-	-	-	-	NT5C
TLS2_k127_1532554_5	1282876.BAOK01000001_gene2019	3.505e-151	492.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TU1G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1062 Zn-dependent alcohol dehydrogenases, class III	MA20_19250	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_1532554_13	994479.GL877879_gene4587	6.022e-72	247.0	COG2229@1|root,COG2229@2|Bacteria,2GJIT@201174|Actinobacteria,4DXCN@85010|Pseudonocardiales	201174|Actinobacteria	S	ATP binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
TLS2_k127_1532554_18	68260.JOAY01000081_gene2412	1.03e-26	113.0	COG1846@1|root,COG1846@2|Bacteria,2II46@201174|Actinobacteria	201174|Actinobacteria	K	Protein of unknown function (DUF742)	-	-	-	-	-	-	-	-	-	-	-	-	DUF742
TLS2_k127_1532554_16	1123320.KB889676_gene2907	2.764e-48	177.0	COG2018@1|root,COG2018@2|Bacteria,2IFB7@201174|Actinobacteria	201174|Actinobacteria	S	Roadblock lc7 family protein	cvnB6	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
TLS2_k127_1532554_10	479432.Sros_1821	1.672e-88	323.0	COG4251@1|root,COG4251@2|Bacteria,2GK6E@201174|Actinobacteria,4EGNB@85012|Streptosporangiales	201174|Actinobacteria	T	Nitrate and nitrite sensing	cvnA6	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,NIT
TLS2_k127_1532554_20	1382356.JQMP01000001_gene1014	2.952e-08	64.0	COG0457@1|root,COG0457@2|Bacteria,2G770@200795|Chloroflexi,27Y28@189775|Thermomicrobia	189775|Thermomicrobia	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
TLS2_k127_1532554_6	1120950.KB892707_gene5004	9.758e-147	483.0	COG1362@1|root,COG1362@2|Bacteria,2GKW4@201174|Actinobacteria,4DPTA@85009|Propionibacteriales	201174|Actinobacteria	E	Aminopeptidase I zinc metalloprotease (M18)	apeB	GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
TLS2_k127_1532554_17	211114.JOEF01000007_gene970	1.441e-38	154.0	COG1321@1|root,COG1321@2|Bacteria,2GK7P@201174|Actinobacteria,4DYN2@85010|Pseudonocardiales	201174|Actinobacteria	K	Transcriptional regulator	sirR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
TLS2_k127_1532554_0	1313172.YM304_07450	2.134e-321	1006.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS2_k127_1532554_9	471852.Tcur_0507	3.64e-94	317.0	COG2141@1|root,COG2141@2|Bacteria,2GMRE@201174|Actinobacteria,4EHHD@85012|Streptosporangiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_1532554_21	1416752.AYME01000016_gene1923	9.512e-06	55.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_1532554_4	345341.KUTG_08194	4.115e-201	653.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4DXBD@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type multidrug transport system, ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_1532554_3	1449976.KALB_3114	4.243e-219	706.0	COG2274@1|root,COG2274@2|Bacteria,2I2QC@201174|Actinobacteria,4EE39@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran,Peptidase_C39
TLS2_k127_1532554_19	1229780.BN381_10244	6.652e-13	74.0	2FACV@1|root,342M7@2|Bacteria,2H6AW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1582455_11	566461.SSFG_03805	1.765e-29	117.0	2AU0F@1|root,31JKB@2|Bacteria,2IT83@201174|Actinobacteria	201174|Actinobacteria	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1582455_10	1229780.BN381_290093	1.495e-60	223.0	COG0457@1|root,COG0457@2|Bacteria	1229780.BN381_290093|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1582455_5	501479.ACNW01000030_gene1440	6.844e-120	395.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2TRW7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	ko:K19745	ko00640,ko01100,map00640,map01100	-	R00919	RC00095	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_1582455_13	1313172.YM304_24830	7.16e-12	72.0	COG0629@1|root,COG0629@2|Bacteria	2|Bacteria	L	single-stranded DNA binding	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_1582455_3	1123504.JQKD01000003_gene667	2.024e-126	411.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria	1224|Proteobacteria	G	fructose-bisphosphate aldolase	fda	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
TLS2_k127_1582455_0	1229780.BN381_80371	2.416e-272	850.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria	201174|Actinobacteria	C	Ferredoxin oxidoreductase	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
TLS2_k127_1582455_2	1313172.YM304_26900	1.477e-147	496.0	COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria	201174|Actinobacteria	C	Ferredoxin oxidoreductase	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
TLS2_k127_1582455_6	1048339.KB913029_gene2112	3.085e-105	362.0	COG4198@1|root,COG4198@2|Bacteria,2GJFV@201174|Actinobacteria,4ESHT@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
TLS2_k127_1582455_9	1313172.YM304_24850	1.605e-61	220.0	COG0647@1|root,COG0647@2|Bacteria,2GK7V@201174|Actinobacteria,4CN5Z@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
TLS2_k127_1582455_8	1313172.YM304_24870	8.583e-70	247.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,4CN67@84992|Acidimicrobiia	84992|Acidimicrobiia	J	FtsJ-like methyltransferase	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
TLS2_k127_1582455_7	1313172.YM304_24880	1.256e-75	264.0	COG0061@1|root,COG0061@2|Bacteria,2GKM2@201174|Actinobacteria,4CN3D@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
TLS2_k127_1582455_1	1313172.YM304_24890	1.31e-160	522.0	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4CMY1@84992|Acidimicrobiia	84992|Acidimicrobiia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
TLS2_k127_1582455_4	1229780.BN381_290087	4.963e-126	415.0	COG4825@1|root,COG4825@2|Bacteria,2GPAA@201174|Actinobacteria,3UXCS@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Thiamine pyrophosphokinase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TPPK_C
TLS2_k127_1665806_7	1229780.BN381_10023	8.753e-31	126.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Fer4_7,HTH_Crp_2,cNMP_binding
TLS2_k127_1665806_5	1313172.YM304_10480	2.801e-58	216.0	COG2890@1|root,COG2890@2|Bacteria,2GMH1@201174|Actinobacteria,4CN5W@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Methyltransferase small domain	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
TLS2_k127_1665806_0	525909.Afer_1808	2.204e-135	439.0	COG0216@1|root,COG0216@2|Bacteria,2GJWG@201174|Actinobacteria,4CMPQ@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS2_k127_1665806_6	1229780.BN381_10019	3.575e-38	156.0	28TNP@1|root,2ZFW6@2|Bacteria,2HAX0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1665806_8	525909.Afer_1810	4.844e-26	109.0	COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4CP0K@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
TLS2_k127_1665806_1	266117.Rxyl_1655	4.743e-132	444.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4CQBF@84995|Rubrobacteria	84995|Rubrobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
TLS2_k127_1665806_3	1211815.CBYP010000063_gene1857	2.88e-98	333.0	COG3173@1|root,COG3173@2|Bacteria,2GMZQ@201174|Actinobacteria,4EXAK@85013|Frankiales	201174|Actinobacteria	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase
TLS2_k127_1665806_2	2074.JNYD01000001_gene5858	2.842e-124	411.0	2BYTM@1|root,2Z7KC@2|Bacteria,2GJ6K@201174|Actinobacteria,4EBZN@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1665806_4	1177928.TH2_04433	2.379e-64	226.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2TT0D@28211|Alphaproteobacteria,2JPG8@204441|Rhodospirillales	204441|Rhodospirillales	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
TLS2_k127_1834522_9	1229780.BN381_10210	2.49e-96	335.0	COG0728@1|root,COG0728@2|Bacteria,2GKN0@201174|Actinobacteria,3UWJN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	MviN-like protein	mviN	GO:0003674,GO:0005215,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TLS2_k127_1834522_13	1313172.YM304_32990	5.442e-81	285.0	COG0313@1|root,COG0313@2|Bacteria,2GJ9Q@201174|Actinobacteria,4CNAK@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
TLS2_k127_1834522_24	1313172.YM304_32980	3.542e-31	125.0	COG1430@1|root,COG1430@2|Bacteria,2IKSE@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
TLS2_k127_1834522_5	1229780.BN381_20071	1.969e-148	486.0	COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria,3UWA3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
TLS2_k127_1834522_23	43759.JNWK01000070_gene4559	1.871e-31	131.0	COG3011@1|root,COG3011@2|Bacteria,2IMHW@201174|Actinobacteria	201174|Actinobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
TLS2_k127_1834522_7	1229780.BN381_20089	5.526e-116	387.0	COG1744@1|root,COG1744@2|Bacteria,2GMFS@201174|Actinobacteria,3UWJF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	ABC transporter substrate-binding protein PnrA-like	bmpA	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
TLS2_k127_1834522_1	2002.JOEQ01000010_gene6228	4.325e-215	680.0	COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria,4EGBM@85012|Streptosporangiales	201174|Actinobacteria	S	ABC transporter	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TLS2_k127_1834522_10	1306174.JODP01000006_gene3709	7.152e-96	336.0	COG4603@1|root,COG4603@2|Bacteria,2GKAZ@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS2_k127_1834522_6	561175.KB894093_gene3218	1.238e-137	451.0	COG1079@1|root,COG1079@2|Bacteria,2GKMB@201174|Actinobacteria,4EIFS@85012|Streptosporangiales	201174|Actinobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS2_k127_1834522_3	1246995.AFR_39565	1.337e-180	580.0	COG0213@1|root,COG0213@2|Bacteria,2GJH5@201174|Actinobacteria,4D8U4@85008|Micromonosporales	201174|Actinobacteria	F	phosphorylase	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
TLS2_k127_1834522_22	585423.KR49_12370	9.867e-32	136.0	COG0295@1|root,COG0295@2|Bacteria,1GNF0@1117|Cyanobacteria,1H0UZ@1129|Synechococcus	1117|Cyanobacteria	F	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
TLS2_k127_1834522_17	1320556.AVBP01000013_gene1773	3.066e-48	181.0	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,2TRJ6@28211|Alphaproteobacteria,43HH2@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	dithiol-disulfide isomerase involved in polyketide biosynthesis	dsb	-	-	-	-	-	-	-	-	-	-	-	DSBA
TLS2_k127_1834522_18	1386089.N865_14705	5.862e-43	165.0	COG2095@1|root,COG2095@2|Bacteria,2GMCM@201174|Actinobacteria,4FGB3@85021|Intrasporangiaceae	201174|Actinobacteria	U	MarC family integral membrane protein	marC	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
TLS2_k127_1834522_20	1246474.ANBE01000052_gene1095	6.829e-33	140.0	COG0644@1|root,COG0644@2|Bacteria,2GUA3@201174|Actinobacteria,4EQKS@85012|Streptosporangiales	201174|Actinobacteria	C	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS2_k127_1834522_8	1254432.SCE1572_33750	5.727e-104	344.0	COG5285@1|root,COG5285@2|Bacteria,1Q78R@1224|Proteobacteria,438ZF@68525|delta/epsilon subdivisions,2X44Q@28221|Deltaproteobacteria,2YY90@29|Myxococcales	28221|Deltaproteobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	1.14.11.18	ko:K00477	ko04146,map04146	-	-	-	ko00000,ko00001,ko01000	-	-	-	PhyH
TLS2_k127_1834522_16	351607.Acel_1704	3.595e-49	182.0	COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria,4ESYT@85013|Frankiales	201174|Actinobacteria	K	Uncharacterized ACR, COG1678	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
TLS2_k127_1834522_4	656024.FsymDg_1004	5.943e-165	533.0	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria,4ERVU@85013|Frankiales	201174|Actinobacteria	F	PFAM Adenosine AMP deaminase	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3313c	A_deaminase
TLS2_k127_1834522_15	298655.KI912266_gene5116	4.136e-60	211.0	COG0655@1|root,COG0655@2|Bacteria,2II43@201174|Actinobacteria,4ESWD@85013|Frankiales	201174|Actinobacteria	S	Multimeric flavodoxin WrbA	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS2_k127_1834522_11	1380386.JIAW01000008_gene6058	4.362e-85	293.0	COG2141@1|root,COG2141@2|Bacteria,2GMUE@201174|Actinobacteria,236IS@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_1834522_25	1385519.N801_03305	7.431e-31	131.0	COG0824@1|root,COG0824@2|Bacteria,2IMQK@201174|Actinobacteria,4FI4K@85021|Intrasporangiaceae	201174|Actinobacteria	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1834522_0	1121272.KB903249_gene1627	8.102e-240	760.0	COG2267@1|root,COG4671@1|root,COG2267@2|Bacteria,COG4671@2|Bacteria,2HU5Q@201174|Actinobacteria,4DBMT@85008|Micromonosporales	201174|Actinobacteria	I	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Glyco_tran_28_C
TLS2_k127_1834522_14	1121019.AUMN01000002_gene145	9.874e-80	282.0	COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_1834522_19	1121924.ATWH01000010_gene1007	1.373e-37	148.0	COG1309@1|root,COG1309@2|Bacteria,2I8Z7@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_1834522_2	1313172.YM304_12820	8.172e-188	597.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4CMU6@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_1834522_21	1313172.YM304_31100	4.479e-32	140.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21471,ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	LysM,Peptidase_M23
TLS2_k127_1834522_12	263358.VAB18032_08725	5.771e-85	287.0	COG1012@1|root,COG1012@2|Bacteria,2GKSN@201174|Actinobacteria,4DAUS@85008|Micromonosporales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_188733_26	287986.DV20_32245	1.367e-26	115.0	COG3427@1|root,COG3427@2|Bacteria,2I3CZ@201174|Actinobacteria,4EDZV@85010|Pseudonocardiales	201174|Actinobacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_188733_19	1298880.AUEV01000003_gene3531	1.126e-50	193.0	COG0346@1|root,COG0346@2|Bacteria,2IKNQ@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_188733_10	1380390.JIAT01000010_gene3916	2.226e-81	278.0	COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,2HEP3@201174|Actinobacteria,4CTHA@84995|Rubrobacteria	84995|Rubrobacteria	T	low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS2_k127_188733_3	298653.Franean1_4670	1.224e-202	638.0	COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria,4ES3N@85013|Frankiales	201174|Actinobacteria	C	PFAM FMN-dependent alpha-hydroxy acid dehydrogenase	lldD	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	1.1.2.3,1.1.3.15	ko:K00101,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00196,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	iNJ661.Rv1872c	FMN_dh
TLS2_k127_188733_1	479432.Sros_8022	1.48e-294	916.0	COG0339@1|root,COG0339@2|Bacteria,2GM2Z@201174|Actinobacteria,4EGUI@85012|Streptosporangiales	201174|Actinobacteria	E	Peptidase family M3	dcp	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
TLS2_k127_188733_28	408672.NBCG_05165	1.303e-15	85.0	COG2364@1|root,COG2364@2|Bacteria,2GKA1@201174|Actinobacteria,4DQWJ@85009|Propionibacteriales	201174|Actinobacteria	S	membrane	-	-	-	ko:K07149	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_188733_11	926564.KI911726_gene2088	4.131e-60	212.0	COG3832@1|root,COG3832@2|Bacteria,2IFFI@201174|Actinobacteria,4F5TK@85017|Promicromonosporaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_188733_24	455632.SGR_1243	7.294e-36	139.0	COG0640@1|root,COG0640@2|Bacteria,2ISNZ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS2_k127_188733_9	1123258.AQXZ01000019_gene3016	7.292e-114	374.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TLS2_k127_188733_12	469383.Cwoe_2725	2.131e-59	221.0	COG0735@1|root,COG0735@2|Bacteria,2IFBR@201174|Actinobacteria,4CTCG@84995|Rubrobacteria	84995|Rubrobacteria	P	Ferric uptake regulator family	-	-	-	ko:K22297	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_188733_0	101510.RHA1_ro05275	0.0	1146.0	COG0376@1|root,COG0376@2|Bacteria,2GJFP@201174|Actinobacteria,4FVND@85025|Nocardiaceae	201174|Actinobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
TLS2_k127_188733_6	1429916.X566_04705	1.19e-135	447.0	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TTHT@28211|Alphaproteobacteria,3JTGZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
TLS2_k127_188733_5	1280946.HY29_13295	1.891e-153	497.0	COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2TUP7@28211|Alphaproteobacteria,43Z1E@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
TLS2_k127_188733_21	1429916.X566_22100	4.125e-43	168.0	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2TS5Y@28211|Alphaproteobacteria,3JUB0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	kdgR	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS2_k127_188733_4	551789.ATVJ01000001_gene1645	9.899e-163	527.0	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TTHT@28211|Alphaproteobacteria,440RY@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
TLS2_k127_188733_17	1214101.BN159_0409	1.388e-52	197.0	COG0412@1|root,COG0412@2|Bacteria,2H3SA@201174|Actinobacteria	201174|Actinobacteria	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS2_k127_188733_25	390989.JOEG01000006_gene857	2.201e-30	125.0	COG5470@1|root,COG5470@2|Bacteria,2IKVB@201174|Actinobacteria,4DG82@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
TLS2_k127_188733_16	1313172.YM304_35350	6.909e-55	203.0	COG1028@1|root,COG1028@2|Bacteria	1313172.YM304_35350|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	-
TLS2_k127_188733_27	926554.KI912637_gene3411	3.13e-24	107.0	COG2832@1|root,COG2832@2|Bacteria,1WK7X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein of unknown function (DUF454)	-	-	-	ko:K09790	-	-	-	-	ko00000	-	-	-	DUF454
TLS2_k127_188733_23	1313172.YM304_03960	4.262e-39	149.0	COG1959@1|root,COG1959@2|Bacteria,2GS0E@201174|Actinobacteria,4CNRF@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TLS2_k127_188733_20	1352941.M877_01585	1.271e-44	168.0	COG2867@1|root,COG2867@2|Bacteria,2IGNZ@201174|Actinobacteria	201174|Actinobacteria	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_188733_13	1283299.AUKG01000004_gene1011	6.499e-57	205.0	COG1309@1|root,COG1309@2|Bacteria,2I9F9@201174|Actinobacteria,4CRDX@84995|Rubrobacteria	84995|Rubrobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_188733_7	196162.Noca_3627	1.902e-126	412.0	COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria,4DP3U@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.1.98.2	ko:K15510	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
TLS2_k127_188733_30	909613.UO65_4757	4.577e-05	51.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	rshA	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
TLS2_k127_188733_29	1033810.HLPCO_001011	2.626e-12	75.0	2DT8Q@1|root,33J6R@2|Bacteria	2|Bacteria	S	ParB-like nuclease domain	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
TLS2_k127_188733_14	103733.JNYO01000064_gene6452	5.738e-56	202.0	COG0406@1|root,COG0406@2|Bacteria,2IAPP@201174|Actinobacteria,4ECXV@85010|Pseudonocardiales	201174|Actinobacteria	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TLS2_k127_188733_15	298654.FraEuI1c_3040	3.571e-55	201.0	COG0494@1|root,COG0494@2|Bacteria,2GN6D@201174|Actinobacteria,4ESRH@85013|Frankiales	201174|Actinobacteria	L	PFAM NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_188733_2	331869.BAL199_15903	4.425e-214	679.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,4BRUQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Flavin-binding monooxygenase-like	-	-	1.14.13.22	ko:K03379	ko00930,ko01120,ko01220,map00930,map01120,map01220	-	R02231,R06622	RC00662,RC01550	ko00000,ko00001,ko01000	-	-	-	FMO-like,Pyr_redox_3
TLS2_k127_188733_18	1108045.GORHZ_164_00370	3.159e-52	199.0	COG2120@1|root,COG2120@2|Bacteria,2IDT2@201174|Actinobacteria,4GGC8@85026|Gordoniaceae	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K22135	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_188733_22	1313172.YM304_06550	1.159e-39	168.0	COG1695@1|root,COG1695@2|Bacteria,2IHK3@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
TLS2_k127_188733_8	469383.Cwoe_0596	1.393e-114	380.0	COG2890@1|root,COG2890@2|Bacteria,2I3R2@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_1888538_13	1306990.BARG01000031_gene3708	1.374e-55	197.0	COG0346@1|root,COG0346@2|Bacteria,2GMTB@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1888538_12	443906.CMM_2858	6.918e-77	268.0	COG2020@1|root,COG2020@2|Bacteria,2IN0C@201174|Actinobacteria,4FKDA@85023|Microbacteriaceae	201174|Actinobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TLS2_k127_1888538_11	1313172.YM304_24400	5.053e-80	274.0	COG2188@1|root,COG2188@2|Bacteria,2HF8W@201174|Actinobacteria,4CN6C@84992|Acidimicrobiia	84992|Acidimicrobiia	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS2_k127_1888538_0	1229780.BN381_430007	0.0	1181.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,3UW9M@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS2_k127_1888538_9	316274.Haur_1720	3.902e-97	328.0	COG3842@1|root,COG3842@2|Bacteria,2G5P8@200795|Chloroflexi,37556@32061|Chloroflexia	32061|Chloroflexia	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
TLS2_k127_1888538_5	42256.RradSPS_1164	6.995e-165	537.0	COG1178@1|root,COG1178@2|Bacteria,2GKPT@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
TLS2_k127_1888538_8	266117.Rxyl_1175	3.73e-106	355.0	COG1840@1|root,COG1840@2|Bacteria,2HRRI@201174|Actinobacteria,4CTU6@84995|Rubrobacteria	84995|Rubrobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
TLS2_k127_1888538_3	1229780.BN381_430032	3.805e-180	575.0	COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,2GKVA@201174|Actinobacteria,3UWPE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Phosphate acyltransferases	plsC2	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_1888538_10	1313172.YM304_21260	1.406e-80	279.0	COG0583@1|root,COG0583@2|Bacteria,2HF8Y@201174|Actinobacteria,4CN2C@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
TLS2_k127_1888538_4	1313172.YM304_21250	2.224e-166	534.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CMQK@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
TLS2_k127_1888538_1	1229780.BN381_430036	1.221e-217	683.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,3UW6Y@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS2_k127_1888538_14	298655.KI912266_gene2080	9.258e-49	188.0	COG0030@1|root,COG0030@2|Bacteria,2I4EV@201174|Actinobacteria,4EXEC@85013|Frankiales	201174|Actinobacteria	J	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
TLS2_k127_1888538_7	1229780.BN381_430038	7.68e-121	395.0	COG0604@1|root,COG0604@2|Bacteria,2GN47@201174|Actinobacteria,3UX8W@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Zinc-binding dehydrogenase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
TLS2_k127_1888538_15	1463881.KL591015_gene591	2.534e-38	150.0	COG0454@1|root,COG0456@2|Bacteria,2IQC7@201174|Actinobacteria	201174|Actinobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_1888538_16	1229780.BN381_350150	3.739e-37	145.0	COG3536@1|root,COG3536@2|Bacteria,2HDP4@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
TLS2_k127_1888538_6	1229780.BN381_80379	1.24e-147	477.0	COG1960@1|root,COG1960@2|Bacteria,2GJ7S@201174|Actinobacteria,3UX8N@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_1888538_2	1179773.BN6_17420	2.846e-216	705.0	COG0454@1|root,COG1042@1|root,COG0456@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4DYY0@85010|Pseudonocardiales	201174|Actinobacteria	CK	Acyl-CoA synthetase (NDP forming)	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
TLS2_k127_1888538_17	1206741.BAFX01000165_gene12	3.773e-32	132.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4FYNR@85025|Nocardiaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS2_k127_1938346_8	1229780.BN381_100101	8.674e-101	332.0	COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria,3UWFH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	glutamine synthetase	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS2_k127_1938346_11	1313172.YM304_38350	4.935e-88	307.0	COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4CN27@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS2_k127_1938346_26	642492.Clole_0160	1.958e-23	106.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia	186801|Clostridia	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_1938346_22	1313172.YM304_38390	5.104e-30	125.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
TLS2_k127_1938346_1	1313172.YM304_38400	1.906e-182	588.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	xdh	-	1.17.1.4,1.2.5.3,1.3.99.16	ko:K00087,ko:K03518,ko:K07302	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
TLS2_k127_1938346_17	1229780.BN381_100107	2.444e-41	159.0	COG0316@1|root,COG0316@2|Bacteria,2IHR0@201174|Actinobacteria,3UWKW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Iron-sulphur cluster biosynthesis	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0071944,GO:1901564	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TLS2_k127_1938346_13	1229780.BN381_100112	4.603e-64	226.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_1938346_5	1313172.YM304_38460	5.025e-137	447.0	COG0489@1|root,COG2151@1|root,COG0489@2|Bacteria,COG2151@2|Bacteria,2H1YI@201174|Actinobacteria,4CNPI@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
TLS2_k127_1938346_15	471853.Bcav_1407	2.474e-61	220.0	COG2154@1|root,COG2154@2|Bacteria,2IHZE@201174|Actinobacteria	201174|Actinobacteria	H	dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
TLS2_k127_1938346_0	404589.Anae109_1853	1.668e-205	655.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2WJVZ@28221|Deltaproteobacteria,2YU94@29|Myxococcales	28221|Deltaproteobacteria	T	GTP-binding protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_1938346_27	1382303.JPOM01000001_gene609	3.573e-11	76.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria,2KFMD@204458|Caulobacterales	204458|Caulobacterales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_1938346_14	1313172.YM304_38470	1.484e-62	232.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	1.3.1.34,3.1.2.6	ko:K00219,ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,Lactamase_B,Rhodanese
TLS2_k127_1938346_24	935866.JAER01000007_gene373	1.96e-26	114.0	COG3030@1|root,COG3030@2|Bacteria,2IA8V@201174|Actinobacteria,4DR8M@85009|Propionibacteriales	201174|Actinobacteria	S	FxsA cytoplasmic membrane protein	-	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
TLS2_k127_1938346_23	1229780.BN381_100117	1.041e-28	119.0	2CC1Y@1|root,32S23@2|Bacteria,2IQS5@201174|Actinobacteria,3UWYX@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB3	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS2_k127_1938346_9	1313172.YM304_38190	7.454e-98	337.0	COG1030@1|root,COG1030@2|Bacteria,2IATM@201174|Actinobacteria	201174|Actinobacteria	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
TLS2_k127_1938346_12	1229780.BN381_100119	2.296e-80	280.0	COG0003@1|root,COG0003@2|Bacteria,2GJ0J@201174|Actinobacteria,3UXHX@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Anion-transporting ATPase	arsA_2	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
TLS2_k127_1938346_7	1229780.BN381_100120	9.183e-105	358.0	COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria,3UX1R@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Anion-transporting ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
TLS2_k127_1938346_21	1229780.BN381_100121	4.955e-31	135.0	COG1366@1|root,COG1366@2|Bacteria,2HPDM@201174|Actinobacteria,3UXK8@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS
TLS2_k127_1938346_19	1229780.BN381_100122	8.497e-34	134.0	COG0745@1|root,COG0745@2|Bacteria	1229780.BN381_100122|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1938346_25	1284352.AOIG01000011_gene1288	6.89e-26	120.0	COG0406@1|root,COG0406@2|Bacteria,1VV4B@1239|Firmicutes,4HVTG@91061|Bacilli,26XXX@186822|Paenibacillaceae	91061|Bacilli	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
TLS2_k127_1938346_18	1229780.BN381_100127	1.063e-38	145.0	COG1694@1|root,COG1694@2|Bacteria,2ISAF@201174|Actinobacteria	201174|Actinobacteria	S	Phosphoribosyl-ATP pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
TLS2_k127_1938346_3	35754.JNYJ01000030_gene7676	2.976e-155	496.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4DB2H@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3708c	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_1938346_2	1229780.BN381_100129	6.919e-173	551.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,3UWDX@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	ACT domain	ask	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
TLS2_k127_1938346_20	1210046.B277_12456	8.565e-34	141.0	COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria,4FG3D@85021|Intrasporangiaceae	201174|Actinobacteria	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
TLS2_k127_1938346_16	1229780.BN381_100131	3.816e-57	210.0	COG4242@1|root,COG4242@2|Bacteria	2|Bacteria	PQ	Belongs to the peptidase S51 family	cphB	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
TLS2_k127_1938346_6	1229780.BN381_100132	2.975e-117	383.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,3UX97@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_1938346_10	1048339.KB913029_gene4637	7.007e-92	310.0	COG2360@1|root,COG2360@2|Bacteria,2IFT7@201174|Actinobacteria,4EVRP@85013|Frankiales	201174|Actinobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
TLS2_k127_1938346_4	1229780.BN381_150069	1.585e-151	495.0	COG2185@1|root,COG2185@2|Bacteria,2I2N3@201174|Actinobacteria,3UX6U@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	B12 binding domain	meaA	-	5.4.99.63	ko:K14447	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09292	RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
TLS2_k127_1977535_9	1218352.B597_002050	1.255e-38	156.0	COG5607@1|root,COG5607@2|Bacteria,1RH6R@1224|Proteobacteria,1S7KA@1236|Gammaproteobacteria,1Z0XH@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
TLS2_k127_1977535_12	1121017.AUFG01000007_gene1327	3.612e-05	57.0	COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria,4FJX7@85021|Intrasporangiaceae	201174|Actinobacteria	V	HNH endonuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222
TLS2_k127_1977535_10	1121380.JNIW01000015_gene2636	7.552e-19	96.0	COG0645@1|root,COG0645@2|Bacteria	2|Bacteria	S	AAA domain	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_33,ROK
TLS2_k127_1977535_0	1313172.YM304_19960	3.862e-312	972.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4CMVH@84992|Acidimicrobiia	84992|Acidimicrobiia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TLS2_k127_1977535_5	1229780.BN381_50118	1.167e-74	265.0	COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria,3UWN6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_1977535_4	525909.Afer_0945	1.728e-101	347.0	COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4CMXX@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF
TLS2_k127_1977535_11	944480.ATUV01000001_gene1189	3.649e-15	79.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,42V1U@68525|delta/epsilon subdivisions,2WR76@28221|Deltaproteobacteria,2M7AK@213113|Desulfurellales	28221|Deltaproteobacteria	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TLS2_k127_1977535_2	1229780.BN381_50115	5.079e-145	468.0	COG0343@1|root,COG0343@2|Bacteria,2GMWY@201174|Actinobacteria,3UWHB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
TLS2_k127_1977535_3	1229780.BN381_50114	2.943e-109	365.0	COG0809@1|root,COG0809@2|Bacteria,2GN51@201174|Actinobacteria	201174|Actinobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
TLS2_k127_1977535_1	1313172.YM304_19880	7.7e-151	496.0	COG2255@1|root,COG2255@2|Bacteria,2GJZF@201174|Actinobacteria,4CMVN@84992|Acidimicrobiia	84992|Acidimicrobiia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
TLS2_k127_1977535_6	1229780.BN381_50109	2.402e-59	212.0	COG0632@1|root,COG0632@2|Bacteria,2GN17@201174|Actinobacteria,3UWUJ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009378,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
TLS2_k127_1977535_7	1229780.BN381_50108	2.008e-48	189.0	COG0817@1|root,COG0817@2|Bacteria,2GJI5@201174|Actinobacteria,3UWKV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
TLS2_k127_1977535_8	324602.Caur_0272	6.037e-44	176.0	COG1131@1|root,COG1131@2|Bacteria,2G6HA@200795|Chloroflexi,376NC@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_1998621_8	469371.Tbis_1167	3.362e-19	88.0	COG0451@1|root,COG0451@2|Bacteria,2GNH5@201174|Actinobacteria,4E1RV@85010|Pseudonocardiales	201174|Actinobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_1998621_1	1313172.YM304_13880	1.902e-194	621.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria,4CNIJ@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
TLS2_k127_1998621_0	110319.CF8_1157	1.196e-248	775.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DP24@85009|Propionibacteriales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_1998621_2	1313172.YM304_13810	8.975e-98	329.0	COG2141@1|root,COG2141@2|Bacteria,2GJ3B@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase, MSMEG_3544 family	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_1998621_4	358220.C380_15020	3.808e-45	181.0	COG0454@1|root,COG0456@2|Bacteria,1PEQ4@1224|Proteobacteria,2W3WY@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_1998621_6	1229780.BN381_640028	4.596e-35	142.0	COG1309@1|root,COG1309@2|Bacteria,2HGC2@201174|Actinobacteria,3UXKK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_1998621_3	321332.CYB_1677	4.157e-96	324.0	COG0111@1|root,COG0111@2|Bacteria,1G417@1117|Cyanobacteria,1H2J2@1129|Synechococcus	1117|Cyanobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_1998621_7	134676.ACPL_4347	6.104e-21	103.0	COG0346@1|root,COG0346@2|Bacteria,2ISPK@201174|Actinobacteria,4DJQG@85008|Micromonosporales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_1998621_5	1307436.PBF_02445	4.059e-39	159.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,4HCS4@91061|Bacilli,1ZCPA@1386|Bacillus	91061|Bacilli	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_1998621_9	698961.CGSMWGv6119V5_03126	2.217e-10	64.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4CYUI@85004|Bifidobacteriales	201174|Actinobacteria	T	Protein of unknown function (DUF2662)	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
TLS2_k127_2003718_1	525909.Afer_1795	2.778e-233	732.0	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4CMWB@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS2_k127_2003718_2	1229780.BN381_10048	5.643e-113	372.0	COG0224@1|root,COG0224@2|Bacteria,2GJ7Q@201174|Actinobacteria,3UWAU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
TLS2_k127_2003718_0	1229780.BN381_10047	4.028e-251	788.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,3UWCR@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
TLS2_k127_2003718_5	1313172.YM304_10630	2.323e-42	161.0	COG0712@1|root,COG0712@2|Bacteria,2HGFG@201174|Actinobacteria,4CND3@84992|Acidimicrobiia	84992|Acidimicrobiia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
TLS2_k127_2003718_8	714313.LSA_09440	1.289e-08	67.0	COG0711@1|root,COG0711@2|Bacteria,1VB85@1239|Firmicutes,4HM64@91061|Bacilli,3F5M8@33958|Lactobacillaceae	91061|Bacilli	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iYO844.BSU36850	ATP-synt_B
TLS2_k127_2003718_7	1313172.YM304_10600	1.518e-24	105.0	COG0636@1|root,COG0636@2|Bacteria,2GQI6@201174|Actinobacteria,4CNBJ@84992|Acidimicrobiia	84992|Acidimicrobiia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
TLS2_k127_2003718_3	1229780.BN381_10042	5.171e-68	239.0	COG0356@1|root,COG0356@2|Bacteria,2H3PR@201174|Actinobacteria,3UWN7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
TLS2_k127_2003718_6	1313172.YM304_10580	5.621e-38	153.0	2DX1J@1|root,342ZM@2|Bacteria,2HGW0@201174|Actinobacteria,4CNX5@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2003718_4	1229780.BN381_10028	2.049e-63	221.0	COG0472@1|root,COG0472@2|Bacteria,2GIT7@201174|Actinobacteria,3UWGE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Glycosyl transferase family 4	rfe	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
TLS2_k127_20589_7	1313172.YM304_16070	1.141e-33	133.0	COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4CNBM@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
TLS2_k127_20589_6	1463854.JOHT01000018_gene3848	3.526e-46	181.0	COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS2_k127_20589_4	1123320.KB889681_gene2588	7.723e-57	207.0	COG0346@1|root,COG0346@2|Bacteria,2IJX2@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_20589_3	1229780.BN381_50159	1.098e-66	234.0	COG0307@1|root,COG0307@2|Bacteria,2GKC5@201174|Actinobacteria,3UWNT@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Lumazine binding domain	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
TLS2_k127_20589_2	446468.Ndas_4503	3.108e-73	256.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4EHN6@85012|Streptosporangiales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TLS2_k127_20589_5	1122917.KB899675_gene235	3.218e-50	198.0	COG0600@1|root,COG0600@2|Bacteria,1TRFD@1239|Firmicutes,4HDSC@91061|Bacilli,26RBB@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter permease	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_20589_0	2074.JNYD01000020_gene2694	9.752e-124	408.0	COG0042@1|root,COG0042@2|Bacteria,2GJ8I@201174|Actinobacteria,4DZKY@85010|Pseudonocardiales	201174|Actinobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090	-	-	-	-	-	-	-	-	-	-	Dus
TLS2_k127_20589_1	1122247.C731_4790	4.121e-98	331.0	COG1960@1|root,COG1960@2|Bacteria,2IBE0@201174|Actinobacteria,23EV2@1762|Mycobacteriaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_2148348_4	1121933.AUHH01000009_gene894	4.242e-123	415.0	COG2197@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,4DT1D@85009|Propionibacteriales	201174|Actinobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HD,HD_5
TLS2_k127_2148348_16	680198.SCAB_43521	1.429e-53	202.0	COG0596@1|root,COG0596@2|Bacteria,2IACG@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_2148348_14	1123320.KB889561_gene4713	1.526e-59	225.0	COG0596@1|root,COG0596@2|Bacteria,2IACG@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_2148348_15	1246448.ANAZ01000048_gene3279	9.973e-55	211.0	COG0500@1|root,COG2226@2|Bacteria,2I13E@201174|Actinobacteria,4EKKK@85012|Streptosporangiales	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_2148348_26	1122223.KB890688_gene1853	0.0002953	53.0	COG0628@1|root,COG0628@2|Bacteria,1WIXU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	COGs COG0628 permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_2148348_13	1313172.YM304_27860	3.995e-76	271.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,4CNDI@84992|Acidimicrobiia	84992|Acidimicrobiia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_2148348_5	1123023.JIAI01000002_gene4683	7.939e-119	406.0	COG3616@1|root,COG3616@2|Bacteria,2GK0N@201174|Actinobacteria,4E1C7@85010|Pseudonocardiales	201174|Actinobacteria	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
TLS2_k127_2148348_1	1206739.BAGJ01000135_gene682	3.406e-138	452.0	COG0277@1|root,COG0277@2|Bacteria,2GJ33@201174|Actinobacteria,4FUJD@85025|Nocardiaceae	201174|Actinobacteria	C	D-arabinono-1,4-lactone oxidase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0016491,GO:0016627,GO:0016632,GO:0019752,GO:0019852,GO:0019853,GO:0030312,GO:0042364,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046364,GO:0046394,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:0080049,GO:1901576	1.1.3.8	ko:K00103	ko00053,ko01100,map00053,map01100	M00129	R00647,R03184,R10053	RC00195,RC00346,RC00869	ko00000,ko00001,ko00002,ko01000	-	-	-	ALO,FAD_binding_4
TLS2_k127_2148348_8	366602.Caul_3640	2.075e-94	325.0	COG3569@1|root,COG3569@2|Bacteria,1MVJ9@1224|Proteobacteria,2TUAH@28211|Alphaproteobacteria,2KG3T@204458|Caulobacterales	204458|Caulobacterales	L	DNA topoisomerase I	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
TLS2_k127_2148348_24	1313172.YM304_06250	1.238e-15	87.0	COG2335@1|root,COG2335@2|Bacteria	2|Bacteria	M	COG2335, Secreted and surface protein containing fasciclin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
TLS2_k127_2148348_11	1313172.YM304_06260	2.418e-79	282.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4CMXS@84992|Acidimicrobiia	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
TLS2_k127_2148348_7	1313172.YM304_06270	1.79e-108	374.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_2148348_23	1313172.YM304_06280	7.433e-28	132.0	2ET4Z@1|root,33KP2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2148348_21	1123322.KB904702_gene253	3.604e-38	150.0	COG1309@1|root,COG1309@2|Bacteria,2IJWX@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_2148348_10	1123322.KB904702_gene255	4.044e-82	280.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_2148348_17	208444.JNYY01000012_gene7789	1.895e-47	179.0	2DQY4@1|root,339C4@2|Bacteria,2GP83@201174|Actinobacteria,4EDXZ@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2148348_6	402881.Plav_2677	1.716e-115	378.0	COG5285@1|root,COG5285@2|Bacteria,1QRDD@1224|Proteobacteria,2U0EC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS2_k127_2148348_9	1313172.YM304_02790	7.773e-88	305.0	COG0179@1|root,COG0179@2|Bacteria,2GKED@201174|Actinobacteria,4CN6Z@84992|Acidimicrobiia	84992|Acidimicrobiia	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
TLS2_k127_2148348_18	312284.A20C1_08113	3.716e-46	180.0	COG0526@1|root,COG0526@2|Bacteria,2IKP1@201174|Actinobacteria,3UXAC@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	CO	Thioredoxin	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin
TLS2_k127_2148348_22	1229780.BN381_420012	3.232e-36	141.0	COG0599@1|root,COG0599@2|Bacteria,2IRPW@201174|Actinobacteria,3UWTK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_2148348_19	675635.Psed_0710	8.73e-46	173.0	COG0716@1|root,COG0716@2|Bacteria,2IQZD@201174|Actinobacteria,4E5JA@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM Flavodoxin	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_1,Flavodoxin_5
TLS2_k127_2148348_25	643867.Ftrac_3299	2.176e-11	75.0	28M8C@1|root,2ZAMI@2|Bacteria,4NM33@976|Bacteroidetes,47MKV@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2148348_2	1108045.GORHZ_118_00340	4.333e-130	427.0	COG1237@1|root,COG1237@2|Bacteria,2I8H7@201174|Actinobacteria	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
TLS2_k127_2148348_0	1120950.KB892753_gene6060	2.714e-189	628.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4DNRF@85009|Propionibacteriales	201174|Actinobacteria	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS2_k127_2148348_20	684949.ATTJ01000001_gene2836	1.849e-39	162.0	COG0454@1|root,COG0454@2|Bacteria,1WJYD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_2148348_3	1120950.KB892709_gene4149	3.277e-129	432.0	COG1132@1|root,COG1132@2|Bacteria,2GMZI@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_2154523_7	479431.Namu_5081	5.883e-42	177.0	COG1680@1|root,COG1835@1|root,COG1680@2|Bacteria,COG1835@2|Bacteria	2|Bacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3,Beta-lactamase,HATPase_c_2
TLS2_k127_2154523_6	314254.OA2633_12935	5.406e-69	250.0	COG2267@1|root,COG2267@2|Bacteria,1QDFI@1224|Proteobacteria,2U244@28211|Alphaproteobacteria,43WHY@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Protein of unknown function (DUF3089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3089
TLS2_k127_2154523_2	1313172.YM304_14010	1.706e-172	561.0	COG0160@1|root,COG0160@2|Bacteria,2GKVH@201174|Actinobacteria,4CMPE@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Aminotransferase class-III	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_2154523_4	266117.Rxyl_2783	1.115e-117	404.0	COG2202@1|root,COG5001@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,2GIZF@201174|Actinobacteria,4CRHY@84995|Rubrobacteria	84995|Rubrobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4
TLS2_k127_2154523_0	1229780.BN381_90023	0.0	1247.0	COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,3UX1U@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
TLS2_k127_2154523_8	1122613.ATUP01000001_gene555	3.134e-38	149.0	COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,2U9GG@28211|Alphaproteobacteria,43Y20@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS2_k127_2154523_5	526225.Gobs_2175	1.508e-108	377.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria	201174|Actinobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4,PAS_8,PAS_9
TLS2_k127_2154523_9	1283283.ATXA01000001_gene509	4.161e-38	155.0	COG1639@1|root,COG1639@2|Bacteria,2GW83@201174|Actinobacteria,4EW8N@85013|Frankiales	201174|Actinobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TLS2_k127_2154523_3	1379270.AUXF01000002_gene1717	1.75e-128	434.0	COG5001@1|root,COG5001@2|Bacteria,1ZT12@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS
TLS2_k127_2154523_1	298654.FraEuI1c_3065	7.635e-202	645.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
TLS2_k127_2154523_14	591158.SSMG_02436	2.608e-14	79.0	2DWZW@1|root,342QA@2|Bacteria,2GQ7R@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_2154523_12	1298863.AUEP01000002_gene1554	1.625e-24	117.0	COG1309@1|root,COG1309@2|Bacteria,2IEU9@201174|Actinobacteria,4DW3K@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_2154523_16	1122622.ATWJ01000014_gene404	5.656e-05	55.0	COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria,4FGRT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB_2
TLS2_k127_2154523_11	1297863.APJF01000003_gene1315	8.334e-28	116.0	COG2128@1|root,COG2128@2|Bacteria,1QW8V@1224|Proteobacteria,2TWTB@28211|Alphaproteobacteria,3JZDW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2154523_10	552811.Dehly_0569	1.204e-28	130.0	COG3568@1|root,COG3568@2|Bacteria,2G7ER@200795|Chloroflexi,34CM1@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_2179014_6	471853.Bcav_4211	1.564e-56	202.0	COG2411@1|root,COG2411@2|Bacteria,2IN3A@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2179014_4	68199.JNZO01000001_gene965	1.412e-88	298.0	COG2120@1|root,COG2120@2|Bacteria,2GMVD@201174|Actinobacteria	201174|Actinobacteria	H	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_2179014_13	1207063.P24_02591	2.126e-12	70.0	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,2UBU3@28211|Alphaproteobacteria,2JT7J@204441|Rhodospirillales	204441|Rhodospirillales	E	Phosphoribosyl-ATP	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
TLS2_k127_2179014_11	1144275.COCOR_03706	6.629e-35	147.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2WIY9@28221|Deltaproteobacteria,2YV4H@29|Myxococcales	28221|Deltaproteobacteria	F	HisG, C-terminal domain	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
TLS2_k127_2179014_2	1242864.D187_008170	1.738e-101	351.0	COG2378@1|root,COG2378@2|Bacteria,1PXCX@1224|Proteobacteria,42V48@68525|delta/epsilon subdivisions,2WPJT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	WYL domain	-	-	-	ko:K13572	-	-	-	-	ko00000,ko03051	-	-	-	HTH_11,WYL
TLS2_k127_2179014_10	105425.BBPL01000001_gene6013	2.071e-37	146.0	COG0748@1|root,COG0748@2|Bacteria,2IFHD@201174|Actinobacteria,2NMWM@228398|Streptacidiphilus	201174|Actinobacteria	P	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_2179014_1	390989.JOEG01000016_gene5612	6.428e-115	383.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4DAWH@85008|Micromonosporales	201174|Actinobacteria	S	ATPase associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA_3
TLS2_k127_2179014_7	1120950.KB892753_gene6092	2.172e-54	207.0	COG1721@1|root,COG1721@2|Bacteria,2I9E2@201174|Actinobacteria,4DQW5@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_2179014_9	1206741.BAFX01000099_gene1050	8.954e-40	168.0	COG4339@1|root,COG4339@2|Bacteria,2GMYQ@201174|Actinobacteria,4G000@85025|Nocardiaceae	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF4031,HD
TLS2_k127_2179014_8	530564.Psta_4651	6.114e-50	201.0	COG1482@1|root,COG1482@2|Bacteria,2IZ3A@203682|Planctomycetes	203682|Planctomycetes	G	mannose-6-phosphate isomerase	pmi	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
TLS2_k127_2179014_0	926560.KE387023_gene2049	6.409e-128	445.0	COG5001@1|root,COG5001@2|Bacteria,1WK20@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4
TLS2_k127_2179014_12	35754.JNYJ01000014_gene4708	1.89e-18	89.0	COG1937@1|root,COG1937@2|Bacteria,2IQ7U@201174|Actinobacteria,4DEZQ@85008|Micromonosporales	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	csoR	-	-	-	-	-	-	-	-	-	-	-	Trns_repr_metal
TLS2_k127_2179014_5	1449976.KALB_82	6.284e-80	281.0	COG2021@1|root,COG2021@2|Bacteria,2I3NA@201174|Actinobacteria,4DZ1P@85010|Pseudonocardiales	201174|Actinobacteria	E	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS2_k127_2179014_3	463191.SSEG_10336	2.567e-97	338.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria	201174|Actinobacteria	Q	ABC transporter (Permease)	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_219391_3	1211815.CBYP010000067_gene125	1.675e-141	470.0	COG0747@1|root,COG0747@2|Bacteria,2ID29@201174|Actinobacteria,4EX5B@85013|Frankiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
TLS2_k127_219391_27	1078020.KEK_06780	2.332e-17	95.0	COG1430@1|root,COG1430@2|Bacteria	2|Bacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
TLS2_k127_219391_10	1229780.BN381_100144	7.906e-108	357.0	COG0413@1|root,COG0413@2|Bacteria,2GJP6@201174|Actinobacteria,3UW6F@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TLS2_k127_219391_6	1229780.BN381_100146	2.031e-122	425.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria	201174|Actinobacteria	M	penicillin-binding protein	ponA	GO:0001666,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0008144,GO:0008150,GO:0008658,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0033554,GO:0036094,GO:0036293,GO:0036294,GO:0042221,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0050896,GO:0051716,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0097159,GO:1901363,GO:1901681	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
TLS2_k127_219391_24	1313172.YM304_42670	1.198e-27	117.0	2CQNK@1|root,332VM@2|Bacteria,2HGHQ@201174|Actinobacteria,4CNEW@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Family of unknown function (DUF5318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5318
TLS2_k127_219391_17	1229780.BN381_100148	1.895e-53	201.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
TLS2_k127_219391_9	1123320.KB889717_gene7660	4.405e-108	364.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria	201174|Actinobacteria	E	dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_219391_21	1075090.GOAMR_54_00250	1.897e-34	148.0	COG0789@1|root,COG0789@2|Bacteria,2INKP@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1
TLS2_k127_219391_1	1306406.ASHX01000001_gene1744	7.568e-159	512.0	COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria	201174|Actinobacteria	J	tRNA nucleotidyltransferase poly(A) polymerase	pcnA	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
TLS2_k127_219391_13	525909.Afer_0024	4.809e-100	336.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4CMXH@84992|Acidimicrobiia	84992|Acidimicrobiia	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TLS2_k127_219391_23	1313172.YM304_42720	9.107e-30	128.0	COG0454@1|root,COG0456@2|Bacteria,2HGG5@201174|Actinobacteria,4CNDG@84992|Acidimicrobiia	84992|Acidimicrobiia	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_219391_25	1229780.BN381_100153	6.771e-25	122.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_219391_15	1313172.YM304_42740	2.986e-77	274.0	COG1307@1|root,COG1307@2|Bacteria,2GIUV@201174|Actinobacteria,4CN2K@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
TLS2_k127_219391_7	1229780.BN381_100154	1.986e-113	384.0	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,3UW9J@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_219391_18	1313172.YM304_42760	1.257e-50	186.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	sigW	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_219391_4	1229780.BN381_100158	5.484e-139	449.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,3UWDR@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_219391_22	468556.AQYG01000030_gene2783	2.166e-33	142.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4GEGG@85026|Gordoniaceae	201174|Actinobacteria	O	Thioredoxin-like domain	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS2_k127_219391_11	1313172.YM304_42840	1.193e-104	347.0	COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,4CMXK@84992|Acidimicrobiia	84992|Acidimicrobiia	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
TLS2_k127_219391_5	1313172.YM304_42850	2.915e-124	402.0	COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4CMSR@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS2_k127_219391_20	525909.Afer_2033	6.508e-35	142.0	COG0357@1|root,COG0357@2|Bacteria,2HGHA@201174|Actinobacteria,4CNEN@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal RNA small subunit methyltransferase G	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
TLS2_k127_219391_16	1313172.YM304_42870	3.21e-56	209.0	COG1847@1|root,COG1847@2|Bacteria,2GPZK@201174|Actinobacteria,4CN3J@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Putative single-stranded nucleic acids-binding domain	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,R3H
TLS2_k127_219391_19	1229780.BN381_100163	4.615e-43	172.0	COG0706@1|root,COG0706@2|Bacteria,2GJBU@201174|Actinobacteria,3UWKK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	60Kd inner membrane protein	yidC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
TLS2_k127_219391_26	525909.Afer_2036	5.033e-20	99.0	COG0759@1|root,COG0759@2|Bacteria,2HH1R@201174|Actinobacteria,4CP20@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
TLS2_k127_219391_31	1223523.H340_04163	1.858e-07	57.0	COG0594@1|root,COG0594@2|Bacteria,2GR42@201174|Actinobacteria	201174|Actinobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	GO:0008150,GO:0040007	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
TLS2_k127_219391_29	435830.HMPREF0045_01346	6.405e-11	64.0	COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria,4D6Q0@85005|Actinomycetales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
TLS2_k127_219391_2	1313172.YM304_00010	8.391e-147	481.0	COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria,4CMQT@84992|Acidimicrobiia	84992|Acidimicrobiia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
TLS2_k127_219391_8	1229780.BN381_100168	4.123e-112	377.0	COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria,3UWB4@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
TLS2_k127_219391_12	1229780.BN381_100169	2.804e-100	338.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,3UWHW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
TLS2_k127_219391_30	2074.JNYD01000004_gene4869	1.164e-09	63.0	COG5512@1|root,COG5512@2|Bacteria,2GNQ4@201174|Actinobacteria,4E3Q7@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the UPF0232 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
TLS2_k127_219391_0	1121877.JQKF01000017_gene188	1.831e-280	876.0	COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,4CMQZ@84992|Acidimicrobiia	84992|Acidimicrobiia	L	TopoisomeraseII	-	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS2_k127_219391_14	1229780.BN381_100172	4.54e-98	328.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,3UWEZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS2_k127_2226987_6	1313172.YM304_02450	0.0007307	51.0	2DH1Q@1|root,2ZY32@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2510)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510
TLS2_k127_2226987_3	1229780.BN381_130058	3.059e-154	494.0	COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria,3UWCZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
TLS2_k127_2226987_2	1313172.YM304_36100	1.314e-155	500.0	COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria,4CMVM@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
TLS2_k127_2226987_1	1229780.BN381_130311	1.114e-186	589.0	COG4447@1|root,COG4447@2|Bacteria,2GM8J@201174|Actinobacteria	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
TLS2_k127_2226987_4	1229780.BN381_130312	1.007e-22	101.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	cysO	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS2_k127_2226987_0	1229780.BN381_130048	1.011e-252	793.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,3UWC5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	UvrD-like helicase C-terminal domain	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS2_k127_2283979_8	929712.KI912613_gene874	1.463e-23	112.0	COG5340@1|root,COG5340@2|Bacteria,2HPSH@201174|Actinobacteria,4CR5Y@84995|Rubrobacteria	84995|Rubrobacteria	K	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2283979_9	1183438.GKIL_2707	7.885e-10	68.0	COG0484@1|root,COG0484@2|Bacteria,1G2FB@1117|Cyanobacteria	1117|Cyanobacteria	O	DnaJ-class molecular chaperone with C-terminal Zn finger domain	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ
TLS2_k127_2283979_1	247633.GP2143_09295	2.692e-149	485.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,1RP33@1236|Gammaproteobacteria,1J6AR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_2283979_3	525904.Tter_2442	1.665e-98	331.0	COG0667@1|root,COG0667@2|Bacteria,2NP23@2323|unclassified Bacteria	2|Bacteria	C	Aldo/keto reductase family	-	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
TLS2_k127_2283979_5	1229780.BN381_50059	3.763e-80	285.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,3UWX5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
TLS2_k127_2283979_7	42256.RradSPS_2410	1.056e-28	134.0	COG1443@1|root,COG1443@2|Bacteria,2HN6K@201174|Actinobacteria,4CQKF@84995|Rubrobacteria	84995|Rubrobacteria	I	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_2283979_4	1229780.BN381_110024	7.392e-84	283.0	COG0302@1|root,COG0302@2|Bacteria,2GP2P@201174|Actinobacteria,3UWJV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3609c	GTP_cyclohydroI
TLS2_k127_2283979_0	1229780.BN381_80228	3.121e-198	628.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,3UX43@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_2283979_6	1229780.BN381_290143	2.289e-31	133.0	COG1564@1|root,COG1564@2|Bacteria	2|Bacteria	H	THIamine pyrophosphokinase	thiN	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
TLS2_k127_2283979_2	44060.JODL01000009_gene1880	7.368e-113	384.0	COG4143@1|root,COG4143@2|Bacteria,2GMWD@201174|Actinobacteria	201174|Actinobacteria	H	ABC transporter, periplasmic binding protein, thiB subfamily	thiB	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
TLS2_k127_2318556_7	58123.JOFJ01000032_gene14	1.822e-18	98.0	COG1843@1|root,COG1843@2|Bacteria,2IQIQ@201174|Actinobacteria	201174|Actinobacteria	N	Flagellar hook capping protein	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgD
TLS2_k127_2318556_10	1197719.A464_2122	2.055e-06	61.0	COG3144@1|root,COG3144@2|Bacteria,1N7XT@1224|Proteobacteria,1SCA6@1236|Gammaproteobacteria,3ZKU3@590|Salmonella	1236|Gammaproteobacteria	N	Flagellar hook-length control protein FliK	fliK	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	-	ko:K02414	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_hook
TLS2_k127_2318556_3	512565.AMIS_76310	2.848e-93	317.0	COG0741@1|root,COG0791@1|root,COG0741@2|Bacteria,COG0791@2|Bacteria,2GIWB@201174|Actinobacteria,4DACY@85008|Micromonosporales	201174|Actinobacteria	M	NlpC/P60 family	-	-	3.4.14.13	ko:K20742,ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SLT
TLS2_k127_2318556_0	1283287.KB822581_gene1474	8.914e-167	539.0	COG1157@1|root,COG1157@2|Bacteria,2GKGV@201174|Actinobacteria,4DPDQ@85009|Propionibacteriales	201174|Actinobacteria	NU	ATP synthase alpha/beta family, nucleotide-binding domain	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS2_k127_2318556_8	35754.JNYJ01000057_gene8708	1.205e-17	92.0	COG1317@1|root,COG1317@2|Bacteria,2IRIT@201174|Actinobacteria,4DF81@85008|Micromonosporales	201174|Actinobacteria	N	Flagellar assembly protein FliH	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
TLS2_k127_2318556_1	1184607.AUCHE_06_00220	3.409e-107	357.0	COG1536@1|root,COG1536@2|Bacteria,2GP1H@201174|Actinobacteria,4F6AR@85018|Dermatophilaceae	201174|Actinobacteria	N	FliG N-terminal domain	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
TLS2_k127_2318556_2	58123.JOFJ01000032_gene21	3.384e-100	347.0	COG1766@1|root,COG1766@2|Bacteria,2HG9F@201174|Actinobacteria	201174|Actinobacteria	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
TLS2_k127_2318556_6	196162.Noca_0760	1.553e-18	91.0	COG1677@1|root,COG1677@2|Bacteria,2GR0F@201174|Actinobacteria,4DSFF@85009|Propionibacteriales	201174|Actinobacteria	NU	Flagellar hook-basal body complex protein FliE	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
TLS2_k127_2318556_4	593907.Celgi_0455	8.263e-39	149.0	COG1558@1|root,COG1558@2|Bacteria,2IKRZ@201174|Actinobacteria,4F2GP@85016|Cellulomonadaceae	201174|Actinobacteria	N	Flagellar basal body rod FlgEFG protein C-terminal	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TLS2_k127_2318556_5	35754.JNYJ01000057_gene8714	1.374e-27	115.0	COG1815@1|root,COG1815@2|Bacteria,2IQWB@201174|Actinobacteria,4DF3E@85008|Micromonosporales	201174|Actinobacteria	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
TLS2_k127_2318556_9	1123024.AUII01000003_gene3330	2.062e-16	92.0	COG2852@1|root,COG2852@2|Bacteria,2GKCY@201174|Actinobacteria,4EB4D@85010|Pseudonocardiales	201174|Actinobacteria	K	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_1,AbiEi_4,DUF559
TLS2_k127_2338844_1	1380393.JHVP01000006_gene4003	2.866e-144	475.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4ES50@85013|Frankiales	201174|Actinobacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2338844_7	1120950.KB892807_gene1564	5.986e-32	136.0	COG3795@1|root,COG3795@2|Bacteria,2IKRD@201174|Actinobacteria,4DUY8@85009|Propionibacteriales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_2338844_9	1304865.JAGF01000001_gene739	1.206e-07	64.0	COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria	201174|Actinobacteria	V	HNH endonuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_2338844_8	1122182.KB903834_gene5859	6.233e-29	126.0	COG1670@1|root,COG1670@2|Bacteria,2IGQ7@201174|Actinobacteria,4DIUI@85008|Micromonosporales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.82	ko:K00663	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Acetyltransf_8
TLS2_k127_2338844_2	472759.Nhal_0362	6.374e-101	349.0	COG2159@1|root,COG2159@2|Bacteria,1QDV1@1224|Proteobacteria,1RYCT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_2338844_5	1303692.SFUL_314	3.026e-54	200.0	COG2334@1|root,COG2334@2|Bacteria,2HCIQ@201174|Actinobacteria	201174|Actinobacteria	M	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2338844_0	471852.Tcur_2255	1.089e-193	613.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,4EGS8@85012|Streptosporangiales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-associated	fdh	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
TLS2_k127_2338844_4	1146883.BLASA_3327	3.322e-87	315.0	COG0300@1|root,COG0300@2|Bacteria,2GJ1R@201174|Actinobacteria	201174|Actinobacteria	Q	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_2338844_6	1206741.BAFX01000044_gene3168	8.888e-38	149.0	COG0500@1|root,COG0500@2|Bacteria,2GMRI@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_2338844_3	1246995.AFR_25055	3.765e-100	337.0	COG3570@1|root,COG3570@2|Bacteria,2GZSC@201174|Actinobacteria,4DC6T@85008|Micromonosporales	201174|Actinobacteria	V	Aminoglycoside/hydroxyurea antibiotic resistance kinase	-	-	2.7.1.72	ko:K04343	-	M00766	R02225	RC00002,RC00078	br01600,ko00000,ko00002,ko01000,ko01504	-	-	-	APH_6_hur
TLS2_k127_2352337_0	1313172.YM304_24190	4.645e-92	308.0	COG1199@1|root,COG1199@2|Bacteria,2GKT8@201174|Actinobacteria	201174|Actinobacteria	KL	helicase	dinG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
TLS2_k127_2352337_1	765420.OSCT_0745	6.538e-62	230.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,CsgG,SLH,VWA,VWA_2
TLS2_k127_2352337_2	649831.L083_4178	5.393e-52	209.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS2_k127_2352337_3	94624.Bpet4900	4.833e-09	64.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VSF1@28216|Betaproteobacteria,3T7A7@506|Alcaligenaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2375363_3	501479.ACNW01000098_gene1194	1.11e-75	270.0	COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2TUFG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_2375363_1	1229780.BN381_450018	1.423e-125	423.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,3UXA2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	rfbP	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS2_k127_2375363_0	1313172.YM304_33170	1.006e-194	626.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,4CMRI@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TLS2_k127_2375363_7	42256.RradSPS_0801	0.0001491	49.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	divIC	-	-	ko:K05589,ko:K12065,ko:K13052	-	-	-	-	ko00000,ko02044,ko03036	3.A.7.11.1	-	-	DivIC
TLS2_k127_2375363_6	926550.CLDAP_28830	3.634e-26	112.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
TLS2_k127_2375363_4	1313172.YM304_33300	1.147e-75	256.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria,4CN0J@84992|Acidimicrobiia	84992|Acidimicrobiia	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_2375363_2	1313172.YM304_33320	8.317e-116	379.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4CMQN@84992|Acidimicrobiia	84992|Acidimicrobiia	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_2375363_5	196162.Noca_1137	3.958e-34	143.0	COG2199@1|root,COG2202@1|root,COG3829@1|root,COG2199@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,2GJNM@201174|Actinobacteria,4DRQP@85009|Propionibacteriales	201174|Actinobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,MASE1,PAS,PAS_3,PAS_4,PAS_8,PAS_9
TLS2_k127_242535_6	471853.Bcav_4211	3.977e-09	66.0	COG2411@1|root,COG2411@2|Bacteria,2IN3A@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_242535_3	247633.GP2143_14551	2.495e-100	341.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_242535_8	1206101.AZXC01000032_gene3418	7.871e-05	53.0	2AYU6@1|root,31QZK@2|Bacteria,2ISXJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_242535_7	1463841.JOIR01000053_gene5430	1.079e-07	64.0	2AYU6@1|root,31QZK@2|Bacteria,2ISXJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_242535_0	1313172.YM304_33560	8.099e-226	705.0	COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4CNE8@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Myo-inositol-1-phosphate synthase	ino1	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
TLS2_k127_242535_4	1313172.YM304_33570	9.711e-77	266.0	COG0583@1|root,COG0583@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
TLS2_k127_242535_2	1121946.AUAX01000015_gene5994	1.214e-111	366.0	COG2334@1|root,COG2334@2|Bacteria,2GU3Q@201174|Actinobacteria,4D9BZ@85008|Micromonosporales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_242535_1	1229780.BN381_640016	5.104e-151	484.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	bglIM	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
TLS2_k127_2486001_9	1089545.KB913037_gene1314	5.585e-18	83.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4E1RW@85010|Pseudonocardiales	201174|Actinobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_2486001_7	1313172.YM304_15390	7.607e-34	139.0	COG1525@1|root,COG1525@2|Bacteria,2GRK1@201174|Actinobacteria	201174|Actinobacteria	L	nuclease	-	-	3.1.31.1	ko:K01174,ko:K07038	-	-	-	-	ko00000,ko01000	-	-	-	SNase
TLS2_k127_2486001_5	1229780.BN381_80213	5.365e-93	318.0	COG3394@1|root,COG3394@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
TLS2_k127_2486001_4	1229780.BN381_80211	5.71e-98	329.0	COG2120@1|root,COG2120@2|Bacteria,2H2NY@201174|Actinobacteria,3UWN4@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	mca	GO:0003674,GO:0005488,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010126,GO:0010127,GO:0016137,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0071704,GO:0098754,GO:1901135,GO:1901657	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_2486001_8	1229780.BN381_410019	2.349e-27	117.0	COG1585@1|root,COG1585@2|Bacteria	2|Bacteria	OU	cellular response to DNA damage stimulus	nfeD	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
TLS2_k127_2486001_3	1229780.BN381_410018	6.117e-115	394.0	COG0330@1|root,COG0330@2|Bacteria,2GJ1U@201174|Actinobacteria,3UWHD@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_2486001_1	929712.KI912613_gene3930	3.292e-139	454.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4CPCY@84995|Rubrobacteria	84995|Rubrobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TLS2_k127_2486001_2	926560.KE387023_gene2049	1.239e-121	426.0	COG5001@1|root,COG5001@2|Bacteria,1WK20@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4
TLS2_k127_2486001_6	1379270.AUXF01000002_gene1717	4.567e-88	325.0	COG5001@1|root,COG5001@2|Bacteria,1ZT12@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS
TLS2_k127_2486001_0	1313172.YM304_29400	4.489e-173	552.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CMRZ@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
TLS2_k127_2500907_3	1313172.YM304_11540	7.036e-181	572.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4CMWF@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS2_k127_2500907_0	479434.Sthe_1357	6.153e-214	683.0	COG1506@1|root,COG1506@2|Bacteria,2G5NN@200795|Chloroflexi,27YSI@189775|Thermomicrobia	189775|Thermomicrobia	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_2500907_2	1313172.YM304_12700	4.963e-198	638.0	COG0111@1|root,COG0111@2|Bacteria,2GJGA@201174|Actinobacteria,4CMQA@84992|Acidimicrobiia	84992|Acidimicrobiia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_2500907_4	710111.FraQA3DRAFT_5766	2.991e-79	271.0	COG0066@1|root,COG0066@2|Bacteria,2GJ8Z@201174|Actinobacteria,4ERFW@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
TLS2_k127_2500907_1	58123.JOFJ01000003_gene2091	1.369e-199	627.0	COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria,4EFIU@85012|Streptosporangiales	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TLS2_k127_2535790_0	1313172.YM304_19350	3.036e-158	509.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4CNPK@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_2535790_1	1313172.YM304_27740	3.081e-148	475.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4CMZT@84992|Acidimicrobiia	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113	ko:K21148	ko04122,map04122	-	R10610	RC03225	ko00000,ko00001,ko01000	-	-	-	PALP
TLS2_k127_2535790_5	1193181.BN10_540045	5.183e-17	87.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_2535790_4	1120950.KB892739_gene3990	2.404e-21	98.0	COG0346@1|root,COG0346@2|Bacteria,2IPGW@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
TLS2_k127_2535790_3	1229780.BN381_80116	3.793e-37	148.0	COG1310@1|root,COG1310@2|Bacteria,2IFB5@201174|Actinobacteria,3UXRV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	JAB/MPN domain	mec	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006508,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016787,GO:0019344,GO:0019538,GO:0019752,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
TLS2_k127_2535790_2	106370.Francci3_0801	1.526e-45	171.0	COG0691@1|root,COG0691@2|Bacteria,2GJX1@201174|Actinobacteria,4ESH9@85013|Frankiales	201174|Actinobacteria	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
TLS2_k127_2535790_6	1123065.ATWL01000003_gene626	1.254e-16	87.0	2E7YB@1|root,332CR@2|Bacteria,2IRTP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
TLS2_k127_2535790_7	273677.BW34_01499	1.368e-08	58.0	COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria,4FNJ1@85023|Microbacteriaceae	201174|Actinobacteria	V	HNH nucleases	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222
TLS2_k127_2656234_8	1229780.BN381_60047	3.425e-43	161.0	COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria,3UWS1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
TLS2_k127_2656234_2	1313172.YM304_37870	6.732e-89	308.0	COG1912@1|root,COG1912@2|Bacteria,2IASJ@201174|Actinobacteria	201174|Actinobacteria	S	transferase activity, transferring alkyl or aryl (other than methyl) groups	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
TLS2_k127_2656234_7	1172188.KB911823_gene519	4.388e-52	188.0	COG4430@1|root,COG4430@2|Bacteria,2IN25@201174|Actinobacteria,4FHP4@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,OmdA
TLS2_k127_2656234_9	1121019.AUMN01000009_gene1868	2.27e-39	159.0	COG0454@1|root,COG0456@2|Bacteria,2IQQX@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
TLS2_k127_2656234_6	1121377.KB906423_gene3739	1.201e-57	224.0	COG1668@1|root,COG1668@2|Bacteria,1WM79@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	CP	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
TLS2_k127_2656234_5	926550.CLDAP_01860	6.969e-77	270.0	COG1131@1|root,COG1131@2|Bacteria,2G6HA@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_2656234_0	1229780.BN381_60045	4.279e-160	519.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,3UWG3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	IQ	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_2656234_3	443255.SCLAV_2346	1.701e-87	294.0	COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria	201174|Actinobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
TLS2_k127_2656234_1	1313172.YM304_37850	4.387e-115	384.0	COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,4CN61@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
TLS2_k127_2656234_4	1229780.BN381_60042	1.645e-79	275.0	COG0181@1|root,COG0181@2|Bacteria,2GMWI@201174|Actinobacteria,3UWP6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
TLS2_k127_270536_6	479431.Namu_1024	2.163e-59	236.0	COG4932@1|root,COG4932@2|Bacteria,2IBRA@201174|Actinobacteria,4EUEI@85013|Frankiales	201174|Actinobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
TLS2_k127_270536_0	446469.Sked_26650	5.792e-165	547.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,RCC1_2
TLS2_k127_270536_2	1454010.JEOE01000022_gene2726	3.581e-119	411.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,RCC1_2
TLS2_k127_270536_7	1089545.KB913037_gene9167	1.645e-43	173.0	2DME4@1|root,32QWA@2|Bacteria,2GVI0@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4255
TLS2_k127_270536_11	1382304.JNIL01000001_gene2116	2.084e-11	72.0	COG4333@1|root,COG5465@1|root,COG4333@2|Bacteria,COG5465@2|Bacteria,1VEFV@1239|Firmicutes,4HPB9@91061|Bacilli	91061|Bacilli	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1643
TLS2_k127_270536_12	1137799.GZ78_19525	1.158e-08	68.0	29W4S@1|root,30HPQ@2|Bacteria,1NQ83@1224|Proteobacteria,1SUP7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_270536_1	1343740.M271_05185	2.454e-143	478.0	COG0464@1|root,COG0464@2|Bacteria,2I8CR@201174|Actinobacteria	201174|Actinobacteria	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
TLS2_k127_270536_4	1313172.YM304_29040	4.521e-72	270.0	COG0697@1|root,COG0697@2|Bacteria,2GK49@201174|Actinobacteria,4CNC2@84992|Acidimicrobiia	84992|Acidimicrobiia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_270536_3	1229780.BN381_150074	1.4e-89	319.0	COG2313@1|root,COG2313@2|Bacteria,2GK19@201174|Actinobacteria,3UWI6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
TLS2_k127_270536_5	1894.JOER01000037_gene3070	5.841e-65	234.0	COG0524@1|root,COG0524@2|Bacteria,2GP1C@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the carbohydrate kinase PfkB family	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS2_k127_270536_9	1449063.JMLS01000001_gene4520	1.956e-39	166.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,4HIMK@91061|Bacilli,26X4A@186822|Paenibacillaceae	91061|Bacilli	D	Maf-like protein	maf	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0022402,GO:0022607,GO:0030428,GO:0032506,GO:0044085,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0090529,GO:1902410,GO:1903047	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
TLS2_k127_270536_10	40571.JOEA01000009_gene3106	6.607e-38	158.0	COG0671@1|root,COG1597@1|root,COG0671@2|Bacteria,COG1597@2|Bacteria,2GM2U@201174|Actinobacteria,4DXZQ@85010|Pseudonocardiales	201174|Actinobacteria	I	Diacylglycerol kinase catalytic domain	bmrU	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	DAGK_cat,PAP2
TLS2_k127_270536_8	479435.Kfla_6233	1.003e-42	160.0	COG0685@1|root,COG0685@2|Bacteria,2IAS3@201174|Actinobacteria,4DSYA@85009|Propionibacteriales	201174|Actinobacteria	E	Methylenetetrahydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR
TLS2_k127_2835909_10	439235.Dalk_2333	3.18e-11	67.0	COG1309@1|root,COG1309@2|Bacteria,1N11B@1224|Proteobacteria,42ZYG@68525|delta/epsilon subdivisions,2WVGK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_2835909_9	2002.JOEQ01000003_gene2484	1.806e-29	122.0	COG2329@1|root,COG2329@2|Bacteria,2IJX7@201174|Actinobacteria,4EPUR@85012|Streptosporangiales	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3291
TLS2_k127_2835909_7	518766.Rmar_0054	4.646e-39	163.0	COG4148@1|root,COG4148@2|Bacteria	2|Bacteria	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
TLS2_k127_2835909_4	1267535.KB906767_gene4846	1.017e-55	202.0	COG4149@1|root,COG4149@2|Bacteria,3Y4EA@57723|Acidobacteria,2JJ3Z@204432|Acidobacteriia	204432|Acidobacteriia	P	Molybdate ABC transporter	-	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
TLS2_k127_2835909_5	333138.LQ50_11540	1.397e-55	216.0	COG0725@1|root,COG0725@2|Bacteria,1U9U3@1239|Firmicutes,4HG4T@91061|Bacilli,1ZQSM@1386|Bacillus	91061|Bacilli	P	Molybdenum ABC transporter	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
TLS2_k127_2835909_8	867903.ThesuDRAFT_02093	2.909e-30	132.0	COG1476@1|root,COG1910@1|root,COG1476@2|Bacteria,COG1910@2|Bacteria,1TRH3@1239|Firmicutes,24ATZ@186801|Clostridia	186801|Clostridia	P	binding domain	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
TLS2_k127_2835909_6	1229780.BN381_150109	5.737e-42	175.0	COG0454@1|root,COG0456@2|Bacteria,2IMVD@201174|Actinobacteria	201174|Actinobacteria	K	GnaT family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_2835909_3	208439.AJAP_10195	1.077e-91	315.0	COG2843@1|root,COG2843@2|Bacteria,2GP72@201174|Actinobacteria,4E1BJ@85010|Pseudonocardiales	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
TLS2_k127_2835909_0	1048339.KB913029_gene2528	7.971e-201	654.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4ERZ6@85013|Frankiales	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_2835909_1	402881.Plav_0577	1.962e-122	404.0	COG2175@1|root,COG2175@2|Bacteria,1Q0C7@1224|Proteobacteria,2TRGF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA	-	-	-	-	-	-	-	-	-	-	-	-	TauD
TLS2_k127_2835909_2	561175.KB894097_gene288	2.704e-120	395.0	COG1387@1|root,COG1387@2|Bacteria,2GMFH@201174|Actinobacteria,4EGUG@85012|Streptosporangiales	201174|Actinobacteria	E	Helix-hairpin-helix domain	polX	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_8,PHP
TLS2_k127_2854870_6	1146883.BLASA_2837	4.13e-129	433.0	COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria	201174|Actinobacteria	E	Extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_2854870_14	1211815.CBYP010000067_gene125	7.7e-18	94.0	COG0747@1|root,COG0747@2|Bacteria,2ID29@201174|Actinobacteria,4EX5B@85013|Frankiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
TLS2_k127_2854870_4	1229780.BN381_290123	2.969e-144	473.0	COG0002@1|root,COG0002@2|Bacteria,2GKQK@201174|Actinobacteria,3UWGI@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_2854870_7	1161401.ASJA01000022_gene125	9.059e-109	369.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2TS98@28211|Alphaproteobacteria,43W6I@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
TLS2_k127_2854870_8	1313172.YM304_20800	5.88e-107	356.0	COG0548@1|root,COG0548@2|Bacteria,2GKDS@201174|Actinobacteria,4CMYC@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
TLS2_k127_2854870_2	1229780.BN381_290121	3.63e-160	531.0	COG4992@1|root,COG4992@2|Bacteria,2GKE9@201174|Actinobacteria,3UW6N@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_2854870_9	1229780.BN381_290120	4.139e-93	322.0	COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria,3UWID@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3,2.1.3.6	ko:K00611,ko:K13252	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_2854870_11	1229780.BN381_290119	2.823e-50	196.0	COG1438@1|root,COG1438@2|Bacteria,2GKA5@201174|Actinobacteria,3UWW0@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Arginine repressor, DNA binding domain	argR	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
TLS2_k127_2854870_0	1313172.YM304_30830	4.017e-223	698.0	COG0137@1|root,COG0137@2|Bacteria,2GK96@201174|Actinobacteria,4CNB6@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Belongs to the argininosuccinate synthase family. Type	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
TLS2_k127_2854870_1	1313172.YM304_20840	8.204e-201	644.0	COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,4CMW7@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
TLS2_k127_2854870_10	1385515.N791_07615	5.297e-67	237.0	COG2094@1|root,COG2094@2|Bacteria,1RE0A@1224|Proteobacteria,1S9CM@1236|Gammaproteobacteria,1X6BU@135614|Xanthomonadales	135614|Xanthomonadales	L	Belongs to the DNA glycosylase MPG family	-	GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
TLS2_k127_2854870_12	1229780.BN381_30027	6.256e-43	167.0	COG1051@1|root,COG1051@2|Bacteria,2I2SX@201174|Actinobacteria,3UXQN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_2854870_3	1229780.BN381_290106	4.861e-156	514.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,3UW69@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
TLS2_k127_2854870_5	452637.Oter_2683	2.526e-131	439.0	COG0162@1|root,COG0162@2|Bacteria,46UVG@74201|Verrucomicrobia,3K7IA@414999|Opitutae	414999|Opitutae	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TLS2_k127_2854870_13	1382230.ASAP_2763	9.198e-27	112.0	2DPM9@1|root,332MQ@2|Bacteria,1NAPW@1224|Proteobacteria,2UWJH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2886888_5	469383.Cwoe_3401	2.957e-30	139.0	28WH1@1|root,2ZIH5@2|Bacteria,2HQVQ@201174|Actinobacteria,4CSNT@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2886888_6	314265.R2601_19005	3.663e-20	106.0	COG2340@1|root,COG2374@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2374@2|Bacteria,COG2931@2|Bacteria,1R62B@1224|Proteobacteria,2U3MK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,HemolysinCabind
TLS2_k127_2886888_3	1313172.YM304_05650	9.758e-61	234.0	COG1624@1|root,COG1624@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	CP_0674	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N,PTS_EIIA_2
TLS2_k127_2886888_7	1137268.AZXF01000013_gene1563	3.867e-11	76.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4
TLS2_k127_2886888_1	743718.Isova_0275	2.826e-90	300.0	COG0640@1|root,COG0640@2|Bacteria,2GJT9@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_2886888_4	743718.Isova_0276	8.104e-41	165.0	COG0491@1|root,COG3832@1|root,COG0491@2|Bacteria,COG3832@2|Bacteria,2IB2K@201174|Actinobacteria	201174|Actinobacteria	S	beta-lactamase domain protein	-	-	3.1.1.81	ko:K13075	ko02024,map02024	-	R08970	RC00713	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
TLS2_k127_2886888_8	1120948.KB903247_gene4630	9.57e-10	69.0	2E10F@1|root,32WGJ@2|Bacteria,2IRR8@201174|Actinobacteria,4EBKZ@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2886888_0	526225.Gobs_1168	6.116e-145	474.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4ES6C@85013|Frankiales	201174|Actinobacteria	E	PFAM Pyridoxal-dependent decarboxylase	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS2_k127_2886888_2	1122138.AQUZ01000090_gene3428	9.682e-71	257.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2ICMZ@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
TLS2_k127_2890460_1	525909.Afer_1846	2.023e-86	289.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4CNG0@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS2_k127_2890460_5	1229780.BN381_150094	1.198e-31	132.0	COG1977@1|root,COG1977@2|Bacteria,2IQBT@201174|Actinobacteria,3UXHU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS2_k127_2890460_3	351607.Acel_0100	4.219e-79	280.0	COG0498@1|root,COG0498@2|Bacteria,2GNM0@201174|Actinobacteria,4ERP2@85013|Frankiales	201174|Actinobacteria	E	TIGRFAM Threonine synthase	thrC3	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_2890460_2	1229780.BN381_150092	4.134e-81	298.0	COG1215@1|root,COG1215@2|Bacteria,2GMKV@201174|Actinobacteria,3UXD7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Glycosyl transferase family 2	gpgS	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	Glycos_transf_2
TLS2_k127_2890460_0	1229780.BN381_150091	9.528e-106	353.0	COG1929@1|root,COG1929@2|Bacteria,2GKHX@201174|Actinobacteria,3UWQJ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Glycerate kinase family	garK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
TLS2_k127_2890460_7	2045.KR76_21530	7.675e-05	52.0	2DP6P@1|root,330SA@2|Bacteria,2GPXH@201174|Actinobacteria,4DS62@85009|Propionibacteriales	201174|Actinobacteria	S	LytR cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C
TLS2_k127_2890460_6	935866.JAER01000038_gene4182	2.277e-23	104.0	2CUM0@1|root,32SVJ@2|Bacteria,2IQG7@201174|Actinobacteria,4DRWZ@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF3263)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3263
TLS2_k127_2890460_4	1449048.JQKU01000005_gene4604	1.474e-34	138.0	COG0237@1|root,COG0237@2|Bacteria,2IIS6@201174|Actinobacteria,239DW@1762|Mycobacteriaceae	201174|Actinobacteria	H	dephospho-CoA kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18
TLS2_k127_2928665_5	55952.BU52_00300	8.089e-11	74.0	COG2895@1|root,COG2895@2|Bacteria,2GJDX@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysNC	-	2.7.7.4	ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_EFTU
TLS2_k127_2928665_0	1370121.AUWS01000007_gene5468	6.178e-126	415.0	COG0175@1|root,COG0175@2|Bacteria,2GN85@201174|Actinobacteria,235PV@1762|Mycobacteriaceae	201174|Actinobacteria	EH	Phosphoadenosine phosphosulfate reductase family	-	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TLS2_k127_2928665_3	196162.Noca_2349	1e-68	240.0	COG0175@1|root,COG0175@2|Bacteria,2GJ3Z@201174|Actinobacteria,4DPGD@85009|Propionibacteriales	201174|Actinobacteria	EH	Belongs to the PAPS reductase family. CysH subfamily	cysH	GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TLS2_k127_2928665_4	103733.JNYO01000006_gene1634	3.296e-59	226.0	COG0035@1|root,COG0035@2|Bacteria,2GPJE@201174|Actinobacteria,4DZ16@85010|Pseudonocardiales	201174|Actinobacteria	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
TLS2_k127_2928665_1	35754.JNYJ01000007_gene2726	1.4e-109	365.0	COG0274@1|root,COG0274@2|Bacteria,2GJIR@201174|Actinobacteria,4DADZ@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS2_k127_2928665_2	391037.Sare_0771	4.013e-107	352.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4D9YX@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_2943483_1	1380393.JHVP01000010_gene2863	7.354e-216	698.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4ERST@85013|Frankiales	201174|Actinobacteria	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	cutL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_2943483_8	1394178.AWOO02000003_gene2800	6.926e-39	151.0	COG2119@1|root,COG2119@2|Bacteria,2GNR0@201174|Actinobacteria,4EI66@85012|Streptosporangiales	201174|Actinobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
TLS2_k127_2943483_7	1313172.YM304_12190	4.405e-53	199.0	COG1230@1|root,COG1230@2|Bacteria,2GMRZ@201174|Actinobacteria,4CNEC@84992|Acidimicrobiia	84992|Acidimicrobiia	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
TLS2_k127_2943483_2	1313172.YM304_16360	5.971e-195	618.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,4CMRP@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT,Malic_M,malic
TLS2_k127_2943483_6	1313172.YM304_38880	3.959e-60	216.0	COG0461@1|root,COG0461@2|Bacteria,2HG8J@201174|Actinobacteria,4CN64@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	-
TLS2_k127_2943483_4	1121430.JMLG01000005_gene782	3.783e-121	400.0	COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,248BT@186801|Clostridia,25ZYS@186807|Peptococcaceae	186801|Clostridia	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_2943483_3	479433.Caci_0296	3.008e-163	529.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
TLS2_k127_2943483_0	1229780.BN381_130019	9.31e-284	891.0	COG0046@1|root,COG0046@2|Bacteria,2GKG6@201174|Actinobacteria,3UWF7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_2943483_9	1313172.YM304_38910	2.894e-32	130.0	2A58G@1|root,30TXM@2|Bacteria,2HG9Z@201174|Actinobacteria,4CN8R@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2943483_5	1229780.BN381_130016	4.271e-87	294.0	COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,3UWG1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
TLS2_k127_294929_8	298655.KI912266_gene4559	2.041e-141	481.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Trans_reg_C
TLS2_k127_294929_23	1394178.AWOO02000028_gene5326	8.224e-07	59.0	COG3945@1|root,COG3945@2|Bacteria,2IIV6@201174|Actinobacteria,4EPKK@85012|Streptosporangiales	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS2_k127_294929_3	1122182.KB903821_gene1303	1.045e-172	574.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4D9J6@85008|Micromonosporales	201174|Actinobacteria	S	drug exporters of the RND superfamily	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_294929_20	402881.Plav_2155	1.951e-14	81.0	COG3631@1|root,COG3631@2|Bacteria,1N5JT@1224|Proteobacteria,2UDZJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
TLS2_k127_294929_11	1229780.BN381_70015	1.452e-77	265.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,3UWPZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	T	Protein of unknown function (DUF2662)	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
TLS2_k127_294929_13	1229780.BN381_70016	5.041e-33	133.0	COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,3UWWG@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	T	Forkhead associated domain	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
TLS2_k127_294929_12	1229780.BN381_70017	2.144e-77	276.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,3UWNU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
TLS2_k127_294929_7	1229780.BN381_70018	7.999e-142	467.0	COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,3UWBG@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Cell cycle protein	rodA	GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
TLS2_k127_294929_4	1229780.BN381_70019	1.285e-153	513.0	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,3UW84@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Penicillin binding protein transpeptidase domain	-	-	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
TLS2_k127_294929_9	1229780.BN381_70020	9.133e-132	444.0	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,3UW9J@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	KLT	Serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_294929_10	1229780.BN381_70023	4.123e-78	269.0	COG0512@1|root,COG0512@2|Bacteria,2GJUX@201174|Actinobacteria,3UWPF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	EH	Peptidase C26	trpG	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS2_k127_294929_26	1454010.JEOE01000051_gene2213	0.0001126	50.0	2E4NY@1|root,32ZHR@2|Bacteria,2GQPW@201174|Actinobacteria,4F1I0@85016|Cellulomonadaceae	201174|Actinobacteria	D	Involved in cell division	crgA	-	-	-	-	-	-	-	-	-	-	-	CrgA
TLS2_k127_294929_19	1348114.OM33_05100	5.414e-21	106.0	COG2340@1|root,COG2931@1|root,COG4932@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1R245@1224|Proteobacteria,1T5GA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_294929_16	1229780.BN381_70025	3.955e-22	98.0	28YVQ@1|root,2ZKNY@2|Bacteria,2HCMJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_294929_2	1229780.BN381_70026	3.768e-187	595.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,3UWHR@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_294929_0	1229780.BN381_70027	5.195e-241	760.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,3UX6T@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
TLS2_k127_294929_17	926564.KI911641_gene2379	1.124e-21	104.0	COG3153@1|root,COG3153@2|Bacteria,2IRC9@201174|Actinobacteria	201174|Actinobacteria	S	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_294929_14	1206737.BAGF01000059_gene3896	1.11e-28	132.0	COG1945@1|root,COG1945@2|Bacteria,2GTGD@201174|Actinobacteria,4G19R@85025|Nocardiaceae	201174|Actinobacteria	S	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC)	-	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
TLS2_k127_294929_22	33876.JNXY01000001_gene5807	2.378e-12	78.0	COG4076@1|root,COG4076@2|Bacteria,2IF3C@201174|Actinobacteria,4DBFG@85008|Micromonosporales	201174|Actinobacteria	S	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_294929_6	926560.KE387023_gene2049	8.172e-146	505.0	COG5001@1|root,COG5001@2|Bacteria,1WK20@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4
TLS2_k127_294929_25	402626.Rpic_2232	9.831e-05	53.0	COG1714@1|root,COG1714@2|Bacteria,1REEC@1224|Proteobacteria,2VRE0@28216|Betaproteobacteria,1K0CS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM RDD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS2_k127_294929_24	159749.K0R6J4	1.148e-05	48.0	COG0790@1|root,KOG1550@2759|Eukaryota,2XET5@2836|Bacillariophyta	2836|Bacillariophyta	MOT	Sel1-like repeats.	-	-	-	ko:K14026	ko04141,map04141	M00403	-	-	ko00000,ko00001,ko00002	-	-	-	-
TLS2_k127_294929_21	1122611.KB903955_gene5549	1.936e-13	76.0	COG0589@1|root,COG0589@2|Bacteria,2IJS7@201174|Actinobacteria,4EPIK@85012|Streptosporangiales	201174|Actinobacteria	T	Universal stress protein family	uspA2	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_294929_15	243231.GSU1929	1.078e-26	115.0	COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,42RSE@68525|delta/epsilon subdivisions,2WP0K@28221|Deltaproteobacteria,43SGX@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
TLS2_k127_294929_1	471852.Tcur_1129	1.483e-226	724.0	COG1506@1|root,COG1506@2|Bacteria,2GJ6A@201174|Actinobacteria,4EFI8@85012|Streptosporangiales	201174|Actinobacteria	E	Dipeptidyl peptidase IV (DPP IV) N-terminal region	pepX	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,PD40,Peptidase_S9
TLS2_k127_294929_5	67373.JOBF01000016_gene4962	2.27e-149	482.0	COG0372@1|root,COG0372@2|Bacteria,2GKST@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the citrate synthase family	citA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS2_k127_294929_18	1120950.KB892823_gene557	3.341e-21	97.0	COG0372@1|root,COG0372@2|Bacteria,2GM3G@201174|Actinobacteria,4DRT9@85009|Propionibacteriales	201174|Actinobacteria	C	Helix-turn-helix domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt,HTH_17
TLS2_k127_2972308_3	1120934.KB894403_gene173	3.427e-120	396.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4DXVN@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2972308_13	36809.MAB_4454c	1.822e-28	121.0	COG3795@1|root,COG3795@2|Bacteria,2IKRD@201174|Actinobacteria,23F1K@1762|Mycobacteriaceae	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_2972308_1	1313172.YM304_38210	4.513e-148	488.0	COG3276@1|root,COG3276@2|Bacteria,2I7V8@201174|Actinobacteria	201174|Actinobacteria	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,SelB-wing_3
TLS2_k127_2972308_4	1313172.YM304_38220	4.668e-116	402.0	COG1921@1|root,COG1921@2|Bacteria,2HFGK@201174|Actinobacteria	201174|Actinobacteria	E	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
TLS2_k127_2972308_9	485913.Krac_5408	2.179e-69	247.0	COG0709@1|root,COG0709@2|Bacteria,2G5W4@200795|Chloroflexi	200795|Chloroflexi	H	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
TLS2_k127_2972308_14	1408419.JHYG01000003_gene252	2.186e-08	59.0	COG1359@1|root,COG1359@2|Bacteria,1NGPW@1224|Proteobacteria,2UHW5@28211|Alphaproteobacteria,2JUVP@204441|Rhodospirillales	204441|Rhodospirillales	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS2_k127_2972308_10	1313172.YM304_02800	3.815e-53	198.0	COG1978@1|root,COG1978@2|Bacteria,2GQU6@201174|Actinobacteria	201174|Actinobacteria	S	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	-	-	1.21.4.1,1.21.4.2	ko:K10672,ko:K10794	ko00330,map00330	-	R02825	RC00790	ko00000,ko00001,ko01000	-	-	-	GRDB
TLS2_k127_2972308_7	1313172.YM304_02800	1.182e-93	312.0	COG1978@1|root,COG1978@2|Bacteria,2GQU6@201174|Actinobacteria	201174|Actinobacteria	S	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	-	-	1.21.4.1,1.21.4.2	ko:K10672,ko:K10794	ko00330,map00330	-	R02825	RC00790	ko00000,ko00001,ko01000	-	-	-	GRDB
TLS2_k127_2972308_12	33898.JRHJ01000018_gene8451	1.551e-29	132.0	COG1940@1|root,COG1940@2|Bacteria,2GMBH@201174|Actinobacteria	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2,ROK
TLS2_k127_2972308_5	1380356.JNIK01000017_gene2844	4.951e-103	353.0	COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,4EU2I@85013|Frankiales	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_2972308_0	1297865.APJD01000003_gene6060	4.151e-270	852.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_2972308_11	252305.OB2597_14366	1.197e-49	196.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2PFAY@252301|Oceanicola	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_2972308_6	2074.JNYD01000031_gene6572	2.991e-100	341.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4E9CZ@85010|Pseudonocardiales	201174|Actinobacteria	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_2972308_2	1123319.AUBE01000005_gene136	1.337e-138	473.0	COG0444@1|root,COG1173@1|root,COG0444@2|Bacteria,COG1173@2|Bacteria,2GIXV@201174|Actinobacteria	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,BPD_transp_1,OppC_N,oligo_HPY
TLS2_k127_2972308_8	2074.JNYD01000031_gene6575	8.484e-88	300.0	COG0601@1|root,COG0601@2|Bacteria,2GK0Z@201174|Actinobacteria,4E2NM@85010|Pseudonocardiales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_297556_12	1313172.YM304_42310	1.292e-31	128.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_297556_6	1229780.BN381_160024	3.882e-89	299.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,3UWJQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TLS2_k127_297556_9	1229780.BN381_160025	3.055e-65	235.0	COG0852@1|root,COG0852@2|Bacteria,2GIRH@201174|Actinobacteria,3UWY9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TLS2_k127_297556_2	1229780.BN381_160026	6.791e-212	665.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,3UWKD@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Belongs to the complex I 49 kDa subunit family	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS2_k127_297556_5	1229780.BN381_160027	3.307e-121	400.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,3UW85@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS2_k127_297556_8	1313172.YM304_35600	8.62e-79	267.0	COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI2	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
TLS2_k127_297556_10	1313172.YM304_35590	2.105e-38	149.0	COG0839@1|root,COG0839@2|Bacteria,2GJB7@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ2	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS2_k127_297556_11	1313172.YM304_35580	2.294e-36	139.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS2_k127_297556_0	1229780.BN381_160032	5.864e-259	815.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,3UWAP@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	CP	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TLS2_k127_297556_1	1229780.BN381_160033	1.194e-232	730.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,3UWBE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_297556_3	1229780.BN381_160034	4.661e-178	571.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,3UWFY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN2	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_297556_7	1313172.YM304_35500	9.482e-87	301.0	COG1565@1|root,COG1565@2|Bacteria	2|Bacteria	P	acr, cog1565	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
TLS2_k127_297556_13	1348663.KCH_57650	3.125e-17	95.0	COG2364@1|root,COG2364@2|Bacteria,2GKA1@201174|Actinobacteria,2M2R9@2063|Kitasatospora	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_297556_4	1229780.BN381_160039	1.527e-176	565.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,3UWEN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_2979167_2	1173021.ALWA01000022_gene618	6.127e-91	310.0	2DKYJ@1|root,30WNV@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF1996)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1996
TLS2_k127_2979167_0	1313172.YM304_03860	3.122e-107	363.0	COG2833@1|root,COG2833@2|Bacteria	2|Bacteria	I	Protein of unknown function (DUF455)	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF455
TLS2_k127_2979167_6	929712.KI912613_gene49	2.909e-32	143.0	COG2720@1|root,COG2720@2|Bacteria,2GISH@201174|Actinobacteria,4CTHM@84995|Rubrobacteria	84995|Rubrobacteria	V	VanW like protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
TLS2_k127_2979167_4	1313172.YM304_03770	4.865e-35	137.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	yphI	-	1.14.99.57	ko:K06996,ko:K21481	-	-	-	-	ko00000,ko01000	-	-	-	ABM
TLS2_k127_2979167_3	1229780.BN381_100019	1.773e-74	252.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,3UWCE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	hrdD	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_299408_4	1068978.AMETH_4852	1.111e-71	252.0	COG1020@1|root,COG1020@2|Bacteria,2GKGU@201174|Actinobacteria,4E2Q6@85010|Pseudonocardiales	201174|Actinobacteria	Q	Wax ester synthase-like Acyl-CoA acyltransferase domain	-	GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
TLS2_k127_299408_1	1313172.YM304_14880	1.633e-152	495.0	COG1875@1|root,COG1875@2|Bacteria,2GK8U@201174|Actinobacteria	201174|Actinobacteria	T	ATPase related to phosphate starvation-inducible protein PhoH	phoH2	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
TLS2_k127_299408_15	112098.XP_008613828.1	0.000243	54.0	COG0417@1|root,KOG1798@2759|Eukaryota	2759|Eukaryota	L	DNA replication proofreading	POLE1	GO:0000228,GO:0000278,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006281,GO:0006284,GO:0006287,GO:0006289,GO:0006297,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007049,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008622,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0018130,GO:0019438,GO:0022616,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02324	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko05166,map00230,map00240,map01100,map03030,map03410,map03420,map05166	M00263	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1,DUF1744
TLS2_k127_299408_0	402881.Plav_2009	5.073e-195	615.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,1JPBG@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	MA20_16305	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C
TLS2_k127_299408_5	1380355.JNIJ01000064_gene5012	2.12e-62	217.0	COG1545@1|root,COG1545@2|Bacteria,1R44D@1224|Proteobacteria,2U5BU@28211|Alphaproteobacteria,3JY08@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	MA20_16300	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
TLS2_k127_299408_9	1229780.BN381_780003	5.704e-42	159.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_299408_14	985665.HPL003_11215	2.941e-09	69.0	COG0589@1|root,COG0589@2|Bacteria,1V6RY@1239|Firmicutes,4HIZM@91061|Bacilli,26YHS@186822|Paenibacillaceae	91061|Bacilli	T	Universal stress protein	uspA1	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_299408_3	436229.JOEH01000010_gene5144	1.223e-91	306.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,2NF0X@228398|Streptacidiphilus	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_299408_6	649638.Trad_1796	9.05e-54	208.0	COG3829@1|root,COG4585@1|root,COG3829@2|Bacteria,COG4585@2|Bacteria,1WJNH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA_3,PAS,PAS_4,PAS_8
TLS2_k127_299408_11	1229780.BN381_350094	3.959e-31	129.0	COG1495@1|root,COG1495@2|Bacteria,2HB8T@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the DsbB family	-	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
TLS2_k127_299408_10	1229780.BN381_350095	3.567e-33	144.0	COG0526@1|root,COG0526@2|Bacteria,2H8ZP@201174|Actinobacteria	201174|Actinobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_299408_13	1121926.AXWO01000020_gene2027	2.86e-27	116.0	COG0589@1|root,COG0589@2|Bacteria,2IQPQ@201174|Actinobacteria,4F0C4@85014|Glycomycetales	201174|Actinobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_299408_2	1146883.BLASA_2837	1.4e-142	472.0	COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria	201174|Actinobacteria	E	Extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_299408_8	653733.Selin_2220	1.355e-43	165.0	COG0853@1|root,COG0853@2|Bacteria	2|Bacteria	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0016485,GO:0016540,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:1901564	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_0139,iYL1228.KPN_00139	Asp_decarbox
TLS2_k127_299408_7	298653.Franean1_0734	7.104e-52	193.0	COG2353@1|root,COG2353@2|Bacteria,2IM4N@201174|Actinobacteria,4EVS9@85013|Frankiales	201174|Actinobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
TLS2_k127_299408_12	1313172.YM304_17480	4.282e-28	121.0	2AUNZ@1|root,31KBW@2|Bacteria,2GP4I@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2786
TLS2_k127_3010319_18	379731.PST_2970	1.274e-07	64.0	COG5607@1|root,COG5607@2|Bacteria,1RH6R@1224|Proteobacteria,1S7KA@1236|Gammaproteobacteria,1Z0XH@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
TLS2_k127_3010319_16	1120934.KB894452_gene2650	9.576e-21	108.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4E2RP@85010|Pseudonocardiales	201174|Actinobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_3010319_3	1229780.BN381_50120	7.948e-136	444.0	COG0124@1|root,COG0124@2|Bacteria,2GIYJ@201174|Actinobacteria,3UWUC@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Histidyl-tRNA synthetase	hisS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TLS2_k127_3010319_1	1121877.JQKF01000045_gene1208	4.812e-213	677.0	COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,4CMU8@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TLS2_k127_3010319_2	1313172.YM304_26410	4.104e-164	529.0	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4CMYY@84992|Acidimicrobiia	84992|Acidimicrobiia	O	MgsA AAA+ ATPase C terminal	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA_assoc_2,MgsA_C,RuvB_N
TLS2_k127_3010319_20	1123322.KB904647_gene1634	0.0001157	47.0	2EGGE@1|root,33A8E@2|Bacteria,2IKUG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3010319_0	1229780.BN381_50129	0.0	1062.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,3UW8U@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS2_k127_3010319_13	1313172.YM304_20300	2.075e-35	144.0	COG0816@1|root,COG0816@2|Bacteria,2HGE6@201174|Actinobacteria,4CNCG@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
TLS2_k127_3010319_10	1146883.BLASA_2344	2.466e-50	197.0	COG1559@1|root,COG1559@2|Bacteria,2GKGQ@201174|Actinobacteria,4ESC2@85013|Frankiales	201174|Actinobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
TLS2_k127_3010319_8	1313172.YM304_20320	1.874e-65	235.0	COG0169@1|root,COG0169@2|Bacteria,2GPQQ@201174|Actinobacteria,4CN43@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
TLS2_k127_3010319_17	324602.Caur_2059	8.086e-08	64.0	COG2199@1|root,COG3706@2|Bacteria,2GBJP@200795|Chloroflexi,37810@32061|Chloroflexia	32061|Chloroflexia	T	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
TLS2_k127_3010319_15	1306174.JODP01000013_gene7518	3.396e-28	124.0	COG1989@1|root,COG1989@2|Bacteria,2GJ7K@201174|Actinobacteria	201174|Actinobacteria	NOU	Peptidase A24A, prepilin type IV	pppA	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
TLS2_k127_3010319_12	688245.CtCNB1_0673	1.576e-37	147.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2VRDN@28216|Betaproteobacteria,4ADJX@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
TLS2_k127_3010319_4	1313172.YM304_20360	1.039e-120	402.0	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria,4CMXJ@84992|Acidimicrobiia	84992|Acidimicrobiia	H	3-dehydroquinate synthase	aroB	-	-	ko:K16020	ko01051,ko01130,map01051,map01130	-	R06592	RC00847	ko00000,ko00001	-	-	-	DHQ_synthase
TLS2_k127_3010319_11	1229780.BN381_50135	1.733e-49	188.0	COG0757@1|root,COG0757@2|Bacteria,2IMBY@201174|Actinobacteria,3UWWA@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786,ko:K16021	ko00400,ko01051,ko01100,ko01110,ko01130,ko01230,map00400,map01051,map01100,map01110,map01130,map01230	M00022	R03084,R06593	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
TLS2_k127_3010319_6	1120948.KB903240_gene3943	3.662e-76	274.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4DYZ4@85010|Pseudonocardiales	201174|Actinobacteria	E	Creatinase Prolidase N-terminal domain	pepQ	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
TLS2_k127_3010319_5	1121877.JQKF01000024_gene2404	7.08e-84	282.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4CMZZ@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TLS2_k127_3010319_14	1229780.BN381_50137	4.414e-32	131.0	COG0781@1|root,COG0781@2|Bacteria,2IM3D@201174|Actinobacteria,3UWXH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	GO:0008150,GO:0040007	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
TLS2_k127_3010319_9	1313172.YM304_20420	2.713e-62	220.0	COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria,4CNB0@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Phosphoribosyl transferase domain	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
TLS2_k127_3010319_7	1136417.AZWE01000003_gene3351	3.651e-71	245.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4D9N9@85008|Micromonosporales	201174|Actinobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_3042892_13	1116232.AHBF01000031_gene6693	2.686e-33	134.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria	201174|Actinobacteria	Q	ABC transporter (Permease)	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_3042892_2	1306990.BARG01000033_gene4072	1.715e-104	346.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3042892_19	1289387.AUKW01000020_gene2732	7.089e-06	57.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807,DUF4097,PA14
TLS2_k127_3042892_3	1463936.JOJI01000014_gene6865	6.017e-89	305.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_3042892_6	1463864.JOGO01000020_gene3452	6.993e-78	279.0	COG4585@1|root,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3,Sensor
TLS2_k127_3042892_14	479431.Namu_1061	8.907e-24	109.0	2EGCD@1|root,33A46@2|Bacteria,2HTZU@201174|Actinobacteria,4EVVG@85013|Frankiales	201174|Actinobacteria	S	Septum formation	-	-	-	-	-	-	-	-	-	-	-	-	Septum_form
TLS2_k127_3042892_11	1122917.KB899681_gene371	5.212e-43	162.0	2ANY6@1|root,31DZ3@2|Bacteria,1VB43@1239|Firmicutes,4IQ37@91061|Bacilli,26XI8@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DUF4280)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4280
TLS2_k127_3042892_1	1121877.JQKF01000031_gene2073	4.253e-253	791.0	COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria,4CMT2@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
TLS2_k127_3042892_12	1120949.KB903329_gene9245	1.814e-33	134.0	2DVEK@1|root,33VIT@2|Bacteria,2IG5Q@201174|Actinobacteria	201174|Actinobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
TLS2_k127_3042892_10	1313172.YM304_23060	3.402e-45	168.0	arCOG11412@1|root,31S84@2|Bacteria,2IHRW@201174|Actinobacteria,4CN5I@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3042892_17	1313172.YM304_23070	3.135e-17	90.0	arCOG11411@1|root,338BB@2|Bacteria,2GTI2@201174|Actinobacteria,4CNDY@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3042892_8	1306174.JODP01000004_gene748	8.785e-49	179.0	2CCBI@1|root,32RVA@2|Bacteria,2IFX8@201174|Actinobacteria	201174|Actinobacteria	S	phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
TLS2_k127_3042892_16	1313172.YM304_23090	1.411e-17	98.0	2BRR2@1|root,32KQU@2|Bacteria,2HGGS@201174|Actinobacteria,4CNE0@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
TLS2_k127_3042892_5	1454010.JEOE01000022_gene2718	1.688e-81	283.0	COG1652@1|root,COG1652@2|Bacteria,2IAAU@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Peptidoglycan-binding	-	-	-	-	-	-	-	-	-	-	-	-	LysM
TLS2_k127_3042892_4	1121877.JQKF01000031_gene2070	9.486e-88	319.0	COG3501@1|root,COG3501@2|Bacteria,2GP13@201174|Actinobacteria,4CNR0@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Rhs element Vgr protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3042892_7	525909.Afer_1418	2.562e-50	195.0	COG3628@1|root,COG3628@2|Bacteria,2IFJ6@201174|Actinobacteria,4CN1C@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Gene 25-like lysozyme	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
TLS2_k127_3042892_0	1283283.ATXA01000031_gene4193	1.622e-265	831.0	COG3299@1|root,COG3299@2|Bacteria,2GM5C@201174|Actinobacteria,4EU2J@85013|Frankiales	201174|Actinobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
TLS2_k127_3042892_9	525909.Afer_1416	2.066e-48	194.0	COG4385@1|root,COG4385@2|Bacteria,2HG76@201174|Actinobacteria,4CN44@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Phage tail protein (Tail_P2_I)	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
TLS2_k127_3042892_15	1454010.JEOE01000022_gene2723	5.33e-22	108.0	2DMR8@1|root,32T5N@2|Bacteria,2IQDY@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3067651_6	1232410.KI421420_gene3175	1.29e-171	554.0	COG0569@1|root,COG4651@1|root,COG0569@2|Bacteria,COG4651@2|Bacteria,1QUQS@1224|Proteobacteria,43CFS@68525|delta/epsilon subdivisions,2X7QU@28221|Deltaproteobacteria,43SY4@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
TLS2_k127_3067651_21	351607.Acel_1202	2.366e-14	77.0	2BZPH@1|root,33EX8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3067651_12	58123.JOFJ01000007_gene633	1.614e-97	331.0	COG1024@1|root,COG1024@2|Bacteria,2GJ1A@201174|Actinobacteria,4EI73@85012|Streptosporangiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	echA15	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_3067651_3	1279019.ARQK01000061_gene1757	4.423e-218	701.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1RP2N@1236|Gammaproteobacteria,1WWIM@135613|Chromatiales	135613|Chromatiales	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	-	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
TLS2_k127_3067651_1	1158182.KB905022_gene1018	3.356e-281	895.0	COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,1T1IP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	synthase	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
TLS2_k127_3067651_0	713586.KB900536_gene50	0.0	1088.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS2_k127_3067651_9	479435.Kfla_1093	3.798e-150	487.0	COG0168@1|root,COG0168@2|Bacteria,2GKKS@201174|Actinobacteria,4DNQE@85009|Propionibacteriales	201174|Actinobacteria	P	Cation transport protein	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS2_k127_3067651_11	414996.IL38_01535	6.586e-119	396.0	COG0168@1|root,COG0168@2|Bacteria,2GKKS@201174|Actinobacteria,4080P@622450|Actinopolysporales	201174|Actinobacteria	P	Cation transport protein	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS2_k127_3067651_14	1229780.BN381_80194	9.931e-78	268.0	COG0569@1|root,COG0569@2|Bacteria,2IA09@201174|Actinobacteria,3UWK6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS2_k127_3067651_13	1048339.KB913029_gene1211	2.884e-79	270.0	COG4122@1|root,COG4122@2|Bacteria,2GP7A@201174|Actinobacteria,4ETYD@85013|Frankiales	201174|Actinobacteria	S	O-methyltransferase	mdmC	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
TLS2_k127_3067651_8	28072.Nos7524_3600	8.101e-151	485.0	COG0082@1|root,COG0082@2|Bacteria,1G12S@1117|Cyanobacteria,1HIZV@1161|Nostocales	1117|Cyanobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.aroC	Chorismate_synt
TLS2_k127_3067651_4	1463856.JOHY01000022_gene4696	2.237e-200	651.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria	201174|Actinobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
TLS2_k127_3067651_2	1122939.ATUD01000007_gene2133	5.777e-252	791.0	COG1164@1|root,COG1164@2|Bacteria,2IGPX@201174|Actinobacteria,4CPUP@84995|Rubrobacteria	84995|Rubrobacteria	E	Oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
TLS2_k127_3067651_7	1313172.YM304_31590	8.456e-156	507.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4CMSN@84992|Acidimicrobiia	201174|Actinobacteria	C	Aldehyde dehydrogenase family	calB	-	1.2.1.3,1.2.99.10	ko:K00128,ko:K22445	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_3067651_20	84531.JMTZ01000005_gene2415	3.471e-23	103.0	COG1917@1|root,COG1917@2|Bacteria,1MZNT@1224|Proteobacteria,1S8TU@1236|Gammaproteobacteria,1X90H@135614|Xanthomonadales	135614|Xanthomonadales	S	Cupin domain	-	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2
TLS2_k127_3067651_15	1048339.KB913029_gene1591	5.001e-67	251.0	COG3001@1|root,COG3001@2|Bacteria,2GW7W@201174|Actinobacteria,4ET0D@85013|Frankiales	201174|Actinobacteria	G	Fructosamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
TLS2_k127_3067651_16	479435.Kfla_5379	2.891e-53	200.0	COG1366@1|root,COG1366@2|Bacteria,2II36@201174|Actinobacteria	201174|Actinobacteria	T	MEDS: MEthanogen/methylotroph, DcmR Sensory domain	-	-	-	-	-	-	-	-	-	-	-	-	MEDS,STAS_2
TLS2_k127_3067651_19	882083.SacmaDRAFT_4018	1.615e-34	146.0	COG2172@1|root,COG2172@2|Bacteria,2GKU6@201174|Actinobacteria,4E18R@85010|Pseudonocardiales	201174|Actinobacteria	T	Anti-sigma regulatory factor (Ser Thr protein kinase)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,MEDS
TLS2_k127_3067651_17	469383.Cwoe_1307	1.406e-49	187.0	COG0394@1|root,COG0394@2|Bacteria,2IM0Q@201174|Actinobacteria,4CQF3@84995|Rubrobacteria	84995|Rubrobacteria	T	Low molecular weight phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS2_k127_3067651_10	263358.VAB18032_13940	1.951e-143	466.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria,4DBH0@85008|Micromonosporales	201174|Actinobacteria	G	Glycosyl transferases group 1	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100	-	R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_3067651_5	219305.MCAG_04706	4.545e-173	554.0	COG0448@1|root,COG0448@2|Bacteria,2I2EF@201174|Actinobacteria,4DC9X@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_3067651_18	42256.RradSPS_1835	6.385e-37	160.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4CRIR@84995|Rubrobacteria	84995|Rubrobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3
TLS2_k127_3160363_5	1229780.BN381_60088	4.34e-52	184.0	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,2GJ7M@201174|Actinobacteria,3UX6A@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	4Fe-4S dicluster domain	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
TLS2_k127_3160363_0	1313172.YM304_39270	2.855e-145	464.0	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,2GJ7M@201174|Actinobacteria,4CMWD@84992|Acidimicrobiia	84992|Acidimicrobiia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
TLS2_k127_3160363_1	479434.Sthe_0722	5.994e-129	443.0	COG1835@1|root,COG2755@1|root,COG1835@2|Bacteria,COG2755@2|Bacteria,2G7EM@200795|Chloroflexi,27Z3D@189775|Thermomicrobia	189775|Thermomicrobia	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS2_k127_3160363_2	1229780.BN381_80199	7.76e-111	369.0	COG1398@1|root,COG1398@2|Bacteria,2GJJF@201174|Actinobacteria	201174|Actinobacteria	I	PFAM Fatty acid desaturase	desC	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
TLS2_k127_3160363_4	1068980.ARVW01000001_gene3353	3.459e-77	262.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,4DZAX@85010|Pseudonocardiales	201174|Actinobacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
TLS2_k127_3160363_6	639283.Snov_1908	1.464e-45	171.0	COG3265@1|root,COG3265@2|Bacteria,1RHD0@1224|Proteobacteria,2UBQX@28211|Alphaproteobacteria,3EZVX@335928|Xanthobacteraceae	28211|Alphaproteobacteria	F	TIGRFAM carbohydrate kinase, thermoresistant glucokinase family	-	-	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	-	R01737	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	SKI
TLS2_k127_3160363_3	1146883.BLASA_0004	3.058e-100	340.0	COG1023@1|root,COG1023@2|Bacteria,2I2DH@201174|Actinobacteria,4ES6V@85013|Frankiales	201174|Actinobacteria	G	6-phosphogluconate dehydrogenase (Decarboxylating)	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
TLS2_k127_3200710_0	1229780.BN381_160007	7.839e-240	769.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,3UWBF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	nuoG	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
TLS2_k127_3200710_4	525909.Afer_0370	1.107e-135	467.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4CMTV@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS2_k127_3200710_5	1229780.BN381_160009	1.112e-94	326.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,3UWSS@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.5.3	ko:K00338,ko:K12143	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3153	Fer4
TLS2_k127_3200710_6	1313172.YM304_04150	1.697e-36	152.0	COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria,4CN8Y@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS2_k127_3200710_7	43354.JOIJ01000018_gene4770	7.193e-28	129.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria,4E4HB@85010|Pseudonocardiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS2_k127_3200710_1	1229780.BN381_160012	4.588e-228	724.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,3UWAP@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	CP	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TLS2_k127_3200710_2	404380.Gbem_3914	4.81e-154	513.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
TLS2_k127_3200710_3	1229780.BN381_160014	3.404e-142	467.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,3UWFY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_3200710_8	591157.SSLG_02048	1.21e-20	102.0	COG2306@1|root,COG2306@2|Bacteria,2GJP9@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF402)	-	-	-	ko:K09145	-	-	-	-	ko00000	-	-	-	DUF402
TLS2_k127_3204773_9	1429046.RR21198_3076	0.0002379	54.0	COG0477@1|root,COG2814@2|Bacteria,2HRTR@201174|Actinobacteria,4G029@85025|Nocardiaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_3204773_3	269799.Gmet_0270	7.433e-126	411.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,42MZS@68525|delta/epsilon subdivisions,2WIQP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	aromatic amino acid beta-eliminating lyase threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_3204773_8	926550.CLDAP_14690	1.251e-09	69.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2G901@200795|Chloroflexi	200795|Chloroflexi	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
TLS2_k127_3204773_4	402881.Plav_0801	6.575e-114	383.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria,1JNTI@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	MA20_07390	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
TLS2_k127_3204773_2	1229780.BN381_80138	2.571e-134	451.0	COG0248@1|root,COG0248@2|Bacteria,2GMME@201174|Actinobacteria	201174|Actinobacteria	FP	Ppx GppA phosphatase	ppx1	GO:0003674,GO:0003824,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
TLS2_k127_3204773_6	1120950.KB892757_gene6499	7.425e-35	138.0	COG3467@1|root,COG3467@2|Bacteria,2IQ9Y@201174|Actinobacteria,4DS34@85009|Propionibacteriales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Pyridox_ox_2
TLS2_k127_3204773_5	1313172.YM304_17340	3.067e-35	145.0	COG0589@1|root,COG0589@2|Bacteria,2H117@201174|Actinobacteria	201174|Actinobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_3204773_0	1282876.BAOK01000001_gene3037	4.977e-190	607.0	COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,2TUFX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.7	ko:K15868	ko00121,map00121	-	-	-	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_3204773_7	1229780.BN381_70028	2.427e-25	110.0	COG5349@1|root,COG5349@2|Bacteria,2HCSH@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
TLS2_k127_3204773_1	1283299.AUKG01000002_gene4730	8.119e-139	465.0	COG0318@1|root,COG0318@2|Bacteria,2GKDF@201174|Actinobacteria,4CPC4@84995|Rubrobacteria	84995|Rubrobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_3261884_1	1150864.MILUP08_45945	2.661e-171	552.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4DAT7@85008|Micromonosporales	201174|Actinobacteria	L	ABC transporter	uvrA2	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_3261884_7	1155718.KB891962_gene381	3.994e-64	240.0	COG0346@1|root,COG0346@2|Bacteria,2IHYP@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_3261884_6	68223.JNZY01000043_gene6038	8.353e-66	229.0	COG2207@1|root,COG2207@2|Bacteria,2IFDE@201174|Actinobacteria	201174|Actinobacteria	K	PFAM helix-turn-helix- domain containing protein, AraC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS2_k127_3261884_12	749222.Nitsa_0752	7.374e-10	69.0	COG0546@1|root,COG0546@2|Bacteria,1NDKE@1224|Proteobacteria,42SW4@68525|delta/epsilon subdivisions,2YPI4@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	HAD-superfamily hydrolase, subfamily IA, variant 1	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_3261884_5	1068978.AMETH_3171	3.451e-89	304.0	COG1024@1|root,COG1024@2|Bacteria,2GKJ6@201174|Actinobacteria,4EA88@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.149,4.2.1.17	ko:K01692,ko:K08299	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093,R10675	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_3261884_8	1229780.BN381_400022	9.292e-31	126.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	MA20_42070	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_3261884_9	1229780.BN381_400023	1.759e-28	120.0	COG0454@1|root,COG0456@2|Bacteria,2HBQK@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_3261884_11	1121877.JQKF01000002_gene1631	1.012e-13	80.0	2DDS5@1|root,2ZJ1Y@2|Bacteria,2HDMP@201174|Actinobacteria,4CP3T@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3261884_0	1313172.YM304_25950	4.463e-237	748.0	COG1351@1|root,COG1351@2|Bacteria,2HBYZ@201174|Actinobacteria,4CMUK@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
TLS2_k127_3261884_3	1229780.BN381_400028	1.165e-122	406.0	COG1473@1|root,COG1473@2|Bacteria,2GNEG@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase, M20	amiB1	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_3261884_10	1313172.YM304_25960	2.33e-26	116.0	COG1597@1|root,COG1597@2|Bacteria,2HCNI@201174|Actinobacteria	201174|Actinobacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3261884_2	1313172.YM304_25970	5.83e-136	450.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,4CMUI@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DEAD-like helicases superfamily	-	-	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C
TLS2_k127_326701_0	1229780.BN381_150139	0.0	1138.0	COG0550@1|root,COG0550@2|Bacteria,2GJU7@201174|Actinobacteria,3UW7H@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
TLS2_k127_326701_8	1246626.BleG1_3222	2.981e-16	88.0	COG2172@1|root,COG2172@2|Bacteria,1V1IA@1239|Firmicutes,4HFPF@91061|Bacilli,1ZF6G@1386|Bacillus	91061|Bacilli	T	Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)	rsbW	GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
TLS2_k127_326701_9	1121385.AQXW01000004_gene2322	3.607e-16	85.0	COG1366@1|root,COG1366@2|Bacteria,2IHQG@201174|Actinobacteria,1ZWXY@145357|Dermacoccaceae	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	rsbV	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS2_k127_326701_1	1229780.BN381_150129	3.76e-234	747.0	COG1205@1|root,COG1205@2|Bacteria,2GJJ6@201174|Actinobacteria,3UX61@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Domain of unknown function (DUF1998)	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
TLS2_k127_326701_5	675635.Psed_2003	2.328e-56	203.0	COG3145@1|root,COG3145@2|Bacteria,2GNBD@201174|Actinobacteria,4E0FZ@85010|Pseudonocardiales	201174|Actinobacteria	L	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
TLS2_k127_326701_10	1313172.YM304_03570	4.922e-11	72.0	COG4961@1|root,COG4961@2|Bacteria	2|Bacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS2_k127_326701_7	1313172.YM304_03590	7.085e-19	97.0	COG2064@1|root,COG2064@2|Bacteria	2|Bacteria	NU	Type II secretion system (T2SS), protein F	tadC	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_326701_11	1219045.BV98_001171	3.512e-10	70.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2VG2S@28211|Alphaproteobacteria,2KE10@204457|Sphingomonadales	204457|Sphingomonadales	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_326701_2	1349820.M707_10675	4.455e-101	348.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,1WANZ@1268|Micrococcaceae	201174|Actinobacteria	U	Secretion system protein	flpF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS2_k127_326701_6	1229780.BN381_150120	7.373e-27	118.0	2FKUI@1|root,34CEY@2|Bacteria,2HCF2@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_326701_3	1048339.KB913029_gene1205	3.624e-74	259.0	COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4ERXM@85013|Frankiales	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	serB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	HAD
TLS2_k127_326701_4	1313172.YM304_03760	2.237e-70	239.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CMST@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_3283290_20	1313172.YM304_18810	2.478e-36	142.0	COG3857@1|root,COG3857@2|Bacteria,2I6QC@201174|Actinobacteria	201174|Actinobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
TLS2_k127_3283290_19	1089544.KB912942_gene7631	5.234e-42	159.0	28M3Q@1|root,2ZAHT@2|Bacteria,2GM5B@201174|Actinobacteria,4E09Q@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3283290_0	1122182.KB903838_gene4199	9.799e-243	772.0	COG0466@1|root,COG0466@2|Bacteria,2GK9D@201174|Actinobacteria,4DA2K@85008|Micromonosporales	201174|Actinobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS2_k127_3283290_14	1286093.C266_12475	9.285e-64	220.0	COG3565@1|root,COG3565@2|Bacteria,1RD7C@1224|Proteobacteria,2VRG8@28216|Betaproteobacteria,1K76N@119060|Burkholderiaceae	28216|Betaproteobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06991	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_3283290_6	1173024.KI912149_gene6383	3.544e-112	378.0	COG4097@1|root,COG4097@2|Bacteria,1G2G1@1117|Cyanobacteria,1JMYB@1189|Stigonemataceae	1117|Cyanobacteria	P	FAD-binding domain	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	EF-hand_7,EF-hand_8,FAD_binding_8,Ferric_reduct,NAD_binding_1,NAD_binding_6
TLS2_k127_3283290_3	1150599.MPHLEI_11949	1.66e-151	499.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,234HK@1762|Mycobacteriaceae	201174|Actinobacteria	I	long-chain-fatty-acid--CoA ligase	fadD15	GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009987,GO:0015645,GO:0016020,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019752,GO:0030312,GO:0032787,GO:0042546,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044464,GO:0071554,GO:0071704,GO:0071766,GO:0071840,GO:0071944,GO:1901576	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS2_k127_3283290_11	408672.NBCG_02725	2.288e-75	270.0	29ZNQ@1|root,30MP9@2|Bacteria,2IJUR@201174|Actinobacteria,4DUE8@85009|Propionibacteriales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS2_k127_3283290_1	1298863.AUEP01000008_gene1242	4.651e-181	581.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DTCF@85009|Propionibacteriales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_3283290_15	330084.JNYZ01000005_gene1160	1.11e-63	234.0	COG0372@1|root,COG0372@2|Bacteria,2H9YP@201174|Actinobacteria	201174|Actinobacteria	C	Citrate synthase	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS2_k127_3283290_24	146922.JOFU01000001_gene275	3.173e-11	78.0	28MY8@1|root,2ZEEV@2|Bacteria,2I3GD@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3283290_17	42256.RradSPS_0559	1.667e-51	199.0	COG0477@1|root,COG2814@2|Bacteria,2IFXN@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_3283290_16	981369.JQMJ01000004_gene4665	3.225e-53	210.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	yugF	GO:0003674,GO:0003824,GO:0016787	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_3283290_7	314254.OA2633_01539	7.116e-96	335.0	COG1024@1|root,COG1024@2|Bacteria,1NDT7@1224|Proteobacteria,2U2R9@28211|Alphaproteobacteria,43XFU@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_3283290_4	1229780.BN381_30040	5.076e-117	399.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	MA20_28095	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
TLS2_k127_3283290_13	1155718.KB891951_gene4426	1.258e-64	243.0	COG3327@1|root,COG3327@2|Bacteria,2HHB2@201174|Actinobacteria	201174|Actinobacteria	K	Phenylacetic acid-responsive transcriptional repressor	-	-	-	ko:K02616	-	-	-	-	ko00000,ko03000	-	-	-	PaaX,PaaX_C
TLS2_k127_3283290_5	743721.Psesu_1293	1.732e-112	375.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RM9E@1236|Gammaproteobacteria,1X4C8@135614|Xanthomonadales	135614|Xanthomonadales	P	Belongs to the ABC transporter superfamily	ugpC	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
TLS2_k127_3283290_10	1220589.CD32_17275	1.724e-78	272.0	COG1175@1|root,COG1175@2|Bacteria,1TSIQ@1239|Firmicutes,4HC0D@91061|Bacilli,3IY0T@400634|Lysinibacillus	91061|Bacilli	U	Glycerol-3-phosphate ABC transporter permease	ugpA	-	-	ko:K02025,ko:K05814	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
TLS2_k127_3283290_8	1157490.EL26_16825	6.516e-81	278.0	COG0395@1|root,COG0395@2|Bacteria,1TR0I@1239|Firmicutes,4HB8C@91061|Bacilli,27APG@186823|Alicyclobacillaceae	91061|Bacilli	U	Binding-protein-dependent transport system inner membrane component	ugpE	-	-	ko:K05815	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
TLS2_k127_3283290_12	292459.STH2179	5.825e-71	267.0	COG1653@1|root,COG1653@2|Bacteria,1TS64@1239|Firmicutes,249GC@186801|Clostridia	186801|Clostridia	G	solute-binding protein	-	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
TLS2_k127_3283290_2	1380390.JIAT01000010_gene3912	5.302e-179	580.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4CPPW@84995|Rubrobacteria	84995|Rubrobacteria	P	sulphate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Sulfate_transp
TLS2_k127_3283290_22	1121946.AUAX01000004_gene579	7.981e-31	124.0	COG0640@1|root,COG0640@2|Bacteria,2IKK2@201174|Actinobacteria,4DE1U@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
TLS2_k127_3283290_21	1449076.JOOE01000003_gene3805	2.802e-34	134.0	COG1605@1|root,COG1605@2|Bacteria,1MZTQ@1224|Proteobacteria,2UCMC@28211|Alphaproteobacteria,2K610@204457|Sphingomonadales	204457|Sphingomonadales	E	chorismate mutase	-	-	5.4.99.5	ko:K04092	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
TLS2_k127_3283290_23	1123320.KB889665_gene1354	4.903e-16	89.0	COG0515@1|root,COG0515@2|Bacteria,2IKPQ@201174|Actinobacteria	201174|Actinobacteria	KLT	Domain of unknown function (DUF4328)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4328
TLS2_k127_3283290_18	446470.Snas_5222	4.188e-45	169.0	2DMC7@1|root,32J0V@2|Bacteria,2I81N@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4395)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4395
TLS2_k127_3283290_9	768671.ThimaDRAFT_1178	1.068e-78	277.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1WXUR@135613|Chromatiales	135613|Chromatiales	P	PFAM Na Picotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
TLS2_k127_335563_2	255470.cbdbA1049	1.84e-174	563.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2G8XD@200795|Chloroflexi,34CY9@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
TLS2_k127_335563_3	58123.JOFJ01000001_gene3216	1.073e-173	578.0	COG1391@1|root,COG1391@2|Bacteria,2GJ91@201174|Actinobacteria,4EFGN@85012|Streptosporangiales	201174|Actinobacteria	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
TLS2_k127_335563_18	1380391.JIAS01000014_gene2007	1.176e-28	124.0	COG1846@1|root,COG1846@2|Bacteria,1PD0X@1224|Proteobacteria,2VBMB@28211|Alphaproteobacteria,2JY08@204441|Rhodospirillales	204441|Rhodospirillales	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS2_k127_335563_16	58123.JOFJ01000001_gene2913	3.568e-34	140.0	COG0454@1|root,COG0456@2|Bacteria,2IMKZ@201174|Actinobacteria,4EPAB@85012|Streptosporangiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	ectA	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	2.3.1.178	ko:K06718	ko00260,ko01100,ko01120,map00260,map01100,map01120	M00033	R06978	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
TLS2_k127_335563_4	1150599.MPHLEI_09244	6.998e-173	552.0	COG0160@1|root,COG0160@2|Bacteria,2GKUY@201174|Actinobacteria,236F9@1762|Mycobacteriaceae	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	ectB	-	2.6.1.76	ko:K00836	ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230	M00033	R06977	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_335563_11	997346.HMPREF9374_1579	4.576e-47	180.0	COG1917@1|root,COG1917@2|Bacteria,1V719@1239|Firmicutes,4HIPQ@91061|Bacilli	91061|Bacilli	S	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant	ectC	-	4.2.1.108	ko:K06720	ko00260,ko01100,ko01120,map00260,map01100,map01120	M00033	R06979	RC01729	ko00000,ko00001,ko00002,ko01000	-	-	-	Ectoine_synth
TLS2_k127_335563_6	123899.JPQP01000004_gene528	9.162e-105	349.0	COG5285@1|root,COG5285@2|Bacteria,1MWD5@1224|Proteobacteria,2VM24@28216|Betaproteobacteria,3T1BF@506|Alcaligenaceae	28216|Betaproteobacteria	Q	Ectoine hydroxylase	thpD	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016705,GO:0016706,GO:0019752,GO:0032787,GO:0042399,GO:0042400,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.14.11.55	ko:K10674	ko00260,ko01120,map00260,map01120	-	R08050	RC00661	ko00000,ko00001,ko01000	-	-	-	PhyH
TLS2_k127_335563_17	1246995.AFR_03490	1.863e-32	144.0	COG2199@1|root,COG2199@2|Bacteria,2ICC1@201174|Actinobacteria,4DGXS@85008|Micromonosporales	201174|Actinobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
TLS2_k127_335563_0	448385.sce4570	4.38e-302	946.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,2YW7G@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2101	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS2_k127_335563_7	479431.Namu_2001	2.539e-77	273.0	COG1131@1|root,COG1131@2|Bacteria,2GKWB@201174|Actinobacteria,4ESB1@85013|Frankiales	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,PLDc_N
TLS2_k127_335563_12	479431.Namu_2002	1.896e-41	168.0	COG1277@1|root,COG1277@2|Bacteria,2GSIR@201174|Actinobacteria	201174|Actinobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_335563_5	644966.Tmar_1342	2.175e-168	546.0	COG0028@1|root,COG0028@2|Bacteria,1UYHG@1239|Firmicutes,24FP1@186801|Clostridia	186801|Clostridia	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_335563_1	1313172.YM304_12030	1.493e-185	589.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4CP4J@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_335563_15	661478.OP10G_0850	3.51e-37	161.0	COG5001@1|root,COG5001@2|Bacteria	2|Bacteria	T	cyclic-guanylate-specific phosphodiesterase activity	-	-	2.7.7.65	ko:K21023	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4
TLS2_k127_335563_14	1003195.SCAT_2172	8.396e-38	152.0	COG0789@1|root,COG0789@2|Bacteria,2GKSZ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_335563_19	935839.JAGJ01000002_gene736	3.387e-24	117.0	COG4762@1|root,COG4762@2|Bacteria,2GND1@201174|Actinobacteria	201174|Actinobacteria	S	YndJ-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YndJ
TLS2_k127_335563_13	1229780.BN381_90094	2.915e-40	166.0	COG4762@1|root,COG4762@2|Bacteria,2IQ4G@201174|Actinobacteria,3UXP2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Domain of unknown function (DUF1990)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1990
TLS2_k127_335563_9	656024.FsymDg_3526	2.11e-65	233.0	COG0346@1|root,COG0346@2|Bacteria,2IG0S@201174|Actinobacteria,4EVCE@85013|Frankiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_335563_10	1122939.ATUD01000006_gene1739	2.353e-53	191.0	COG2207@1|root,COG2207@2|Bacteria,2IFDE@201174|Actinobacteria,4CT84@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS2_k127_335563_8	1114959.SZMC14600_02404	3.993e-68	254.0	COG2850@1|root,COG2850@2|Bacteria,2GMR2@201174|Actinobacteria,4DYRP@85010|Pseudonocardiales	201174|Actinobacteria	S	Cupin superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_4
TLS2_k127_3466658_12	1203566.HMPREF1285_00118	2.819e-15	81.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,22JMG@1653|Corynebacteriaceae	201174|Actinobacteria	V	ABC transporter, ATP-binding protein	drrA_2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3466658_11	536232.CLM_0983	1.54e-19	102.0	COG1668@1|root,COG1668@2|Bacteria,1V5UX@1239|Firmicutes,24CYV@186801|Clostridia,36DKR@31979|Clostridiaceae	186801|Clostridia	CP	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
TLS2_k127_3466658_7	1313172.YM304_19850	1.153e-48	179.0	COG1225@1|root,COG1225@2|Bacteria,2IJVV@201174|Actinobacteria,4CN6R@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS2_k127_3466658_13	861299.J421_2367	1.357e-12	80.0	2FK9E@1|root,34BX2@2|Bacteria,1ZTYM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3466658_2	1229780.BN381_50101	2.628e-93	321.0	COG0217@1|root,COG0217@2|Bacteria,2GJ4G@201174|Actinobacteria,3UWE9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Transcriptional regulator	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TLS2_k127_3466658_6	1123023.JIAI01000029_gene4439	1.609e-61	221.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4DXHN@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
TLS2_k127_3466658_0	1313172.YM304_19820	2.141e-147	471.0	COG0214@1|root,COG0214@2|Bacteria,2GK1T@201174|Actinobacteria,4CMSX@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
TLS2_k127_3466658_8	1313172.YM304_19810	2.365e-45	181.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria,4CN8S@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3048) C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
TLS2_k127_3466658_10	1229780.BN381_50098	1.685e-27	122.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	-	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS2_k127_3466658_4	1047013.AQSP01000139_gene2393	3.717e-68	237.0	COG1704@1|root,COG1704@2|Bacteria,2NPIW@2323|unclassified Bacteria	2|Bacteria	S	LemA family	lemA2	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
TLS2_k127_3466658_1	1229780.BN381_50176	5.19e-124	407.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,3UXCT@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Glycosyltransferase Family 4	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
TLS2_k127_3466658_3	1313172.YM304_19760	3.059e-85	291.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,4CN56@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Bacterial lipid A biosynthesis acyltransferase	-	-	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
TLS2_k127_3466658_5	1313172.YM304_19750	8.785e-65	228.0	COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4CN1P@84992|Acidimicrobiia	84992|Acidimicrobiia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_3466658_9	1313172.YM304_19740	1.254e-34	135.0	2F9Q3@1|root,34209@2|Bacteria,2H616@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3513060_8	1048339.KB913029_gene867	2.41e-123	410.0	COG1749@1|root,COG1749@2|Bacteria,2I62V@201174|Actinobacteria,4ERJI@85013|Frankiales	201174|Actinobacteria	N	Flagellar basal body protein FlaE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
TLS2_k127_3513060_31	649831.L083_7708	3.35e-16	82.0	COG1582@1|root,COG1582@2|Bacteria,2GRTC@201174|Actinobacteria,4DG1Y@85008|Micromonosporales	201174|Actinobacteria	N	Flagellar protein (FlbD)	flbD	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
TLS2_k127_3513060_15	526225.Gobs_0968	1.555e-63	228.0	COG1291@1|root,COG1291@2|Bacteria,2I92C@201174|Actinobacteria,4ESI3@85013|Frankiales	201174|Actinobacteria	N	MotA/TolQ/ExbB proton channel family	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
TLS2_k127_3513060_23	446462.Amir_2336	3.48e-48	184.0	COG1360@1|root,COG1360@2|Bacteria,2IG81@201174|Actinobacteria,4EAE3@85010|Pseudonocardiales	201174|Actinobacteria	N	Membrane MotB of proton-channel complex MotA/MotB	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
TLS2_k127_3513060_34	1033730.CAHG01000007_gene2542	6.684e-12	73.0	COG1580@1|root,COG1580@2|Bacteria,2ITFQ@201174|Actinobacteria,4DV67@85009|Propionibacteriales	201174|Actinobacteria	N	Flagellar basal body-associated protein FliL	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
TLS2_k127_3513060_13	35754.JNYJ01000057_gene8697	8.576e-72	254.0	COG1868@1|root,COG1868@2|Bacteria,2ICP2@201174|Actinobacteria,4DBUV@85008|Micromonosporales	201174|Actinobacteria	N	Flagellar motor switch protein FliM	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
TLS2_k127_3513060_26	1048339.KB913029_gene873	1.989e-27	124.0	COG1886@1|root,COG1886@2|Bacteria,2IGHQ@201174|Actinobacteria,4ET05@85013|Frankiales	201174|Actinobacteria	N	Flagellar motor switch	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
TLS2_k127_3513060_36	33876.JNXY01000042_gene3867	8.969e-05	51.0	COG3190@1|root,COG3190@2|Bacteria,2GREW@201174|Actinobacteria,4DGI3@85008|Micromonosporales	201174|Actinobacteria	N	Flagellar biosynthesis protein, FliO	fliO	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
TLS2_k127_3513060_11	351607.Acel_0857	6.707e-76	265.0	COG1338@1|root,COG1338@2|Bacteria,2GP63@201174|Actinobacteria,4ERQ3@85013|Frankiales	201174|Actinobacteria	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
TLS2_k127_3513060_29	367299.JOEE01000006_gene750	4.493e-24	104.0	COG1987@1|root,COG1987@2|Bacteria,2IQ8H@201174|Actinobacteria,4FJT2@85021|Intrasporangiaceae	201174|Actinobacteria	NU	Bacterial export proteins, family 3	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
TLS2_k127_3513060_21	1048339.KB913029_gene877	1.487e-48	184.0	COG1684@1|root,COG1684@2|Bacteria,2IDEX@201174|Actinobacteria,4ESQK@85013|Frankiales	201174|Actinobacteria	NU	Bacterial export proteins, family 1	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
TLS2_k127_3513060_12	1048339.KB913029_gene878	7.351e-72	257.0	COG1377@1|root,COG1377@2|Bacteria,2HF6J@201174|Actinobacteria,4ES6G@85013|Frankiales	201174|Actinobacteria	NU	FlhB HrpN YscU SpaS Family	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
TLS2_k127_3513060_2	351607.Acel_0861	1.887e-236	749.0	COG1298@1|root,COG1298@2|Bacteria,2IB5S@201174|Actinobacteria,4ERJU@85013|Frankiales	201174|Actinobacteria	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
TLS2_k127_3513060_30	593907.Celgi_0480	1.851e-20	103.0	COG3064@1|root,COG3064@2|Bacteria,2IK60@201174|Actinobacteria,4F2WZ@85016|Cellulomonadaceae	201174|Actinobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3513060_27	1303518.CCALI_02086	9.098e-27	114.0	COG1699@1|root,COG1699@2|Bacteria	2|Bacteria	S	bacterial-type flagellum assembly	fliW	-	-	ko:K13626	-	-	-	-	ko00000,ko02035	-	-	-	FliW
TLS2_k127_3513060_32	1120934.KB894432_gene6189	1.022e-14	82.0	COG1551@1|root,COG1551@2|Bacteria,2GRPH@201174|Actinobacteria,4ECMV@85010|Pseudonocardiales	201174|Actinobacteria	T	Global regulator protein family	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
TLS2_k127_3513060_16	1229780.BN381_100183	1.629e-63	228.0	COG1191@1|root,COG1191@2|Bacteria,2GKBK@201174|Actinobacteria	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_3513060_20	479434.Sthe_0129	3.71e-57	218.0	COG3434@1|root,COG3434@2|Bacteria,2GA08@200795|Chloroflexi,27Y73@189775|Thermomicrobia	189775|Thermomicrobia	T	Diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TLS2_k127_3513060_14	1380356.JNIK01000002_gene4823	6.148e-67	251.0	COG0477@1|root,COG2814@2|Bacteria,2H1TJ@201174|Actinobacteria,4EUWV@85013|Frankiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_3513060_25	1313172.YM304_12650	5.382e-29	124.0	COG3255@1|root,COG3255@2|Bacteria,2HGCC@201174|Actinobacteria,4CNAG@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3513060_24	1313172.YM304_33900	6.164e-45	167.0	COG1149@1|root,COG1149@2|Bacteria,2IMA0@201174|Actinobacteria	201174|Actinobacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_21,Fer4_4
TLS2_k127_3513060_17	649747.HMPREF0083_01493	2.752e-61	222.0	COG1647@1|root,COG1647@2|Bacteria,1TT4Y@1239|Firmicutes,4HE1V@91061|Bacilli	91061|Bacilli	S	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
TLS2_k127_3513060_28	710687.KI912270_gene1977	1.647e-26	112.0	COG0721@1|root,COG0721@2|Bacteria,2IQJN@201174|Actinobacteria,239Z5@1762|Mycobacteriaceae	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
TLS2_k127_3513060_3	1229780.BN381_10093	6.969e-199	649.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,3UWA6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_3513060_5	1229780.BN381_10094	1.679e-186	614.0	COG0064@1|root,COG0064@2|Bacteria,2GJJH@201174|Actinobacteria,3UW72@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
TLS2_k127_3513060_9	1313172.YM304_41490	2.629e-101	340.0	COG1131@1|root,COG1131@2|Bacteria,2GK1W@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3513060_19	1313172.YM304_41500	4.28e-60	218.0	COG1277@1|root,COG1277@2|Bacteria,2GKKP@201174|Actinobacteria	201174|Actinobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS2_k127_3513060_10	1313172.YM304_41510	1.364e-79	276.0	COG1131@1|root,COG1131@2|Bacteria,2GKWB@201174|Actinobacteria	201174|Actinobacteria	V	abc transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3513060_1	1121877.JQKF01000003_gene1462	1.218e-256	816.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4CMQ6@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Dehydratase family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS2_k127_3513060_22	743718.Isova_0883	3.078e-48	184.0	COG0666@1|root,COG0666@2|Bacteria,2I3AT@201174|Actinobacteria,4F52A@85017|Promicromonosporaceae	201174|Actinobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_3513060_0	1229780.BN381_80039	1.22e-300	933.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,3UWFJ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Thiamine pyrophosphate enzyme, central domain	ilvB	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030312,GO:0030976,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3003c	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_3513060_18	1313172.YM304_11440	3.565e-60	228.0	COG0440@1|root,COG0440@2|Bacteria,2GJCH@201174|Actinobacteria,4CN3W@84992|Acidimicrobiia	84992|Acidimicrobiia	E	ACT domain	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
TLS2_k127_3513060_6	1229780.BN381_80043	8.728e-171	545.0	COG0059@1|root,COG0059@2|Bacteria,2GKXA@201174|Actinobacteria,3UWCK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008677,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
TLS2_k127_3513060_4	222534.KB893772_gene4669	1.091e-197	625.0	COG2873@1|root,COG2873@2|Bacteria,2I2EB@201174|Actinobacteria,4ES02@85013|Frankiales	201174|Actinobacteria	E	PFAM Cys Met metabolism	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3340	Cys_Met_Meta_PP
TLS2_k127_3513060_35	1150864.MILUP08_41737	1.49e-09	66.0	COG3557@1|root,COG3557@2|Bacteria,2H6MF@201174|Actinobacteria,4DJH5@85008|Micromonosporales	201174|Actinobacteria	J	Protein of unknown function (DUF402)	-	-	-	-	-	-	-	-	-	-	-	-	DUF402
TLS2_k127_3513060_7	351607.Acel_0114	2.441e-153	495.0	COG1932@1|root,COG1932@2|Bacteria,2GKYK@201174|Actinobacteria,4ERX6@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TLS2_k127_3513060_33	1137271.AZUM01000004_gene4067	2.577e-13	76.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4DY66@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Aminotransferase class I and II	aspC	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_3524588_10	749927.AMED_7758	1.377e-88	316.0	COG1024@1|root,COG1024@2|Bacteria,2HHR6@201174|Actinobacteria,4DXU9@85010|Pseudonocardiales	201174|Actinobacteria	I	enoyl-CoA hydratase	Echdc	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_3524588_11	1125863.JAFN01000001_gene1053	6.929e-66	250.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
TLS2_k127_3524588_0	1380393.JHVP01000001_gene2646	2.566e-240	755.0	COG2072@1|root,COG2072@2|Bacteria,2H38Q@201174|Actinobacteria,4EX9F@85013|Frankiales	201174|Actinobacteria	P	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like,NAD_binding_8,Pyr_redox_2
TLS2_k127_3524588_13	998088.B565_3544	1.642e-45	177.0	COG1180@1|root,COG1180@2|Bacteria,1QIC8@1224|Proteobacteria,1RRCB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	radical SAM domain protein	yjjW	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
TLS2_k127_3524588_3	196162.Noca_1873	6.957e-192	612.0	COG1328@1|root,COG1328@2|Bacteria,2I5BQ@201174|Actinobacteria	201174|Actinobacteria	F	Protein of unknown function (DUF3029)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3029
TLS2_k127_3524588_14	1215092.PA6_018_00110	1.985e-36	148.0	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,1RYTA@1236|Gammaproteobacteria,1YGFJ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_3524588_9	1282876.BAOK01000001_gene1702	5.767e-92	312.0	COG0673@1|root,COG0673@2|Bacteria,1R0FZ@1224|Proteobacteria,2TYQZ@28211|Alphaproteobacteria,4BSUC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_3524588_16	1150864.MILUP08_44500	2.379e-09	66.0	COG3548@1|root,COG3548@2|Bacteria,2GRE3@201174|Actinobacteria,4DG17@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
TLS2_k127_3524588_7	1229780.BN381_40050	9.967e-119	394.0	COG1232@1|root,COG1232@2|Bacteria	2|Bacteria	H	protoporphyrinogen oxidase activity	hemY	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS2_k127_3524588_8	935866.JAER01000014_gene1799	9.831e-107	351.0	COG1733@1|root,COG1733@2|Bacteria,2GMK5@201174|Actinobacteria,4DQI2@85009|Propionibacteriales	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR,SCP2
TLS2_k127_3524588_5	1122609.AUGT01000010_gene3755	9.942e-154	508.0	COG1960@1|root,COG1960@2|Bacteria,2HY9F@201174|Actinobacteria,4DTUE@85009|Propionibacteriales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3524588_6	1297570.MESS4_750064	6.615e-151	496.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TRWG@28211|Alphaproteobacteria,43I37@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C
TLS2_k127_3524588_12	1298863.AUEP01000001_gene976	8.618e-52	187.0	COG1846@1|root,COG1846@2|Bacteria,2GKZA@201174|Actinobacteria,4DQN9@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_3524588_1	1313172.YM304_16690	4.139e-210	675.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4CMUP@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS2_k127_3524588_15	1313172.YM304_30600	4.197e-35	154.0	COG2185@1|root,COG2185@2|Bacteria,2IFJD@201174|Actinobacteria,4CN3T@84992|Acidimicrobiia	201174|Actinobacteria	I	B12 binding domain	icmB	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
TLS2_k127_3524588_2	1333998.M2A_2717	3.061e-196	622.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,4BRSC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	MA20_17005	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_3524588_4	1313172.YM304_18860	1.039e-173	550.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_3524588_17	446470.Snas_2996	3.002e-05	48.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4EY7B@85014|Glycomycetales	201174|Actinobacteria	G	Glucose-6-phosphate dehydrogenase, NAD binding domain	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TLS2_k127_3589917_2	1229780.BN381_10207	1.36e-84	286.0	COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,3UWET@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
TLS2_k127_3589917_0	861299.J421_0304	3.541e-162	544.0	COG5001@1|root,COG5001@2|Bacteria,1ZT12@142182|Gemmatimonadetes	2|Bacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9
TLS2_k127_3589917_1	1229780.BN381_10208	9.461e-128	419.0	COG0263@1|root,COG0263@2|Bacteria,2GM8U@201174|Actinobacteria,3UWHH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
TLS2_k127_3589917_3	314265.R2601_20711	5.988e-19	99.0	COG2340@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria,1R62B@1224|Proteobacteria,2U3MK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,HemolysinCabind
TLS2_k127_3589917_4	443143.GM18_4316	1.237e-08	66.0	COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,1MU3S@1224|Proteobacteria,42Q3Z@68525|delta/epsilon subdivisions,2WJPC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the peptidase S8 family	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Big_2,CUB,He_PIG,Peptidase_S8
TLS2_k127_364141_8	543632.JOJL01000002_gene8338	1.423e-50	188.0	COG2203@1|root,COG2203@2|Bacteria,2IQAM@201174|Actinobacteria,4DCWS@85008|Micromonosporales	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS2_k127_364141_5	1120950.KB892804_gene1472	1.402e-72	253.0	COG2203@1|root,COG2203@2|Bacteria,2GQ2V@201174|Actinobacteria,4DQJ3@85009|Propionibacteriales	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS2_k127_364141_4	1299327.I546_1353	2.276e-79	271.0	COG1741@1|root,COG1741@2|Bacteria,2GJV3@201174|Actinobacteria,23325@1762|Mycobacteriaceae	201174|Actinobacteria	S	Belongs to the pirin family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
TLS2_k127_364141_2	1313172.YM304_33360	7.281e-125	407.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4CMRT@84992|Acidimicrobiia	84992|Acidimicrobiia	O	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
TLS2_k127_364141_1	1313172.YM304_33370	1.538e-126	415.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4CNNX@84992|Acidimicrobiia	84992|Acidimicrobiia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS2_k127_364141_11	1306174.JODP01000006_gene3139	4.581e-31	138.0	COG1975@1|root,COG1975@2|Bacteria,2GIZS@201174|Actinobacteria	201174|Actinobacteria	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS2_k127_364141_3	1313172.YM304_33390	3.803e-106	349.0	COG1975@1|root,COG1975@2|Bacteria,2GIZS@201174|Actinobacteria,4CN04@84992|Acidimicrobiia	84992|Acidimicrobiia	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS2_k127_364141_10	266117.Rxyl_0118	6.859e-32	134.0	COG2068@1|root,COG2068@2|Bacteria,2GK5R@201174|Actinobacteria,4CQMI@84995|Rubrobacteria	84995|Rubrobacteria	S	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TLS2_k127_364141_7	298654.FraEuI1c_2743	1.884e-67	242.0	COG3427@1|root,COG3427@2|Bacteria,2GKTQ@201174|Actinobacteria,4ESNJ@85013|Frankiales	201174|Actinobacteria	S	carbon monoxide dehydrogenase subunit G	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
TLS2_k127_364141_9	1229780.BN381_630015	1.399e-49	181.0	COG1507@1|root,COG1507@2|Bacteria,2I8CS@201174|Actinobacteria,3UWSU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Protein of unknown function (DUF501)	-	-	-	ko:K09009	-	-	-	-	ko00000	-	-	-	DUF501
TLS2_k127_364141_6	68170.KL590477_gene2477	2.525e-68	249.0	COG0248@1|root,COG0248@2|Bacteria,2GJBN@201174|Actinobacteria,4E04G@85010|Pseudonocardiales	201174|Actinobacteria	FP	PFAM Ppx GppA phosphatase	ppx2	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
TLS2_k127_364141_0	1313172.YM304_07780	4.799e-132	434.0	COG0075@1|root,COG0075@2|Bacteria,2GM5F@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase	-	-	2.6.1.112,2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830,ko:K00839	ko00230,ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00230,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588,R10908	RC00006,RC00008,RC00018,RC03305	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TLS2_k127_3677499_1	1032480.MLP_40450	2.982e-60	218.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	MA20_06080	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25
TLS2_k127_3677499_4	1313172.YM304_25100	9.182e-24	114.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_3677499_2	1229780.BN381_60050	5.728e-41	156.0	COG1396@1|root,COG1396@2|Bacteria,2IKVI@201174|Actinobacteria,3UXII@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
TLS2_k127_3677499_0	1313172.YM304_37900	1.202e-134	447.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4CMYV@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyl transferase 4-like domain	-	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_3677499_3	1313172.YM304_37890	2.507e-37	146.0	2AZ39@1|root,31R9K@2|Bacteria,2GMCY@201174|Actinobacteria	201174|Actinobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
TLS2_k127_3705293_1	743718.Isova_2136	1.573e-93	313.0	COG0030@1|root,COG0030@2|Bacteria,2GIZ8@201174|Actinobacteria,4F5KW@85017|Promicromonosporaceae	201174|Actinobacteria	J	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_3705293_0	566461.SSFG_07743	3.784e-142	454.0	COG2518@1|root,COG2518@2|Bacteria,2I37N@201174|Actinobacteria	201174|Actinobacteria	O	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
TLS2_k127_3705293_5	1122182.KB903837_gene3803	3.13e-37	147.0	2DE8Y@1|root,2ZM0Q@2|Bacteria	2|Bacteria	S	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_3705293_3	2002.JOEQ01000004_gene2925	1.34e-70	247.0	COG1946@1|root,COG1946@2|Bacteria	2|Bacteria	I	acyl-CoA hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
TLS2_k127_3705293_4	1206737.BAGF01000041_gene2472	8.982e-61	213.0	COG1733@1|root,COG1733@2|Bacteria,2GMQG@201174|Actinobacteria,4G069@85025|Nocardiaceae	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS2_k127_3705293_2	1120948.KB903240_gene4102	6.033e-82	279.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4E398@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_3705293_6	1028801.RG1141_PA14470	6.013e-06	48.0	COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2TRB8@28211|Alphaproteobacteria,4B8F7@82115|Rhizobiaceae	28211|Alphaproteobacteria	CH	4-hydroxybenzoate	pobA	GO:0000166,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016705,GO:0016709,GO:0018659,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
TLS2_k127_3743405_1	247633.GP2143_12911	1.428e-184	594.0	COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,1RY0V@1236|Gammaproteobacteria,1J7G3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_3743405_0	67352.JODS01000002_gene1651	2.556e-229	718.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TLS2_k127_3743405_5	1869.MB27_06780	2.513e-16	93.0	COG1357@1|root,COG1357@2|Bacteria,2GK0E@201174|Actinobacteria,4DDVI@85008|Micromonosporales	201174|Actinobacteria	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
TLS2_k127_3743405_3	1122622.ATWJ01000012_gene1092	1.386e-71	268.0	COG1444@1|root,COG1670@1|root,COG1444@2|Bacteria,COG1670@2|Bacteria,2IIWF@201174|Actinobacteria,4FJV1@85021|Intrasporangiaceae	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128,2.3.1.82	ko:K00663,ko:K03790	-	-	-	-	ko00000,ko01000,ko01504,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_3
TLS2_k127_3743405_4	500153.JOEK01000009_gene5134	7.446e-49	198.0	COG1680@1|root,COG1680@2|Bacteria,2GN1H@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_3743405_2	479435.Kfla_0728	3.12e-121	393.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria,4DU3U@85009|Propionibacteriales	201174|Actinobacteria	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
TLS2_k127_3745155_8	477641.MODMU_5496	1.153e-28	126.0	COG1403@1|root,COG1403@2|Bacteria,2HAHI@201174|Actinobacteria,4ESDB@85013|Frankiales	201174|Actinobacteria	L	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_3745155_4	1123024.AUII01000028_gene2518	2.05e-45	177.0	COG0406@1|root,COG0406@2|Bacteria,2HRP2@201174|Actinobacteria,4EAZ6@85010|Pseudonocardiales	201174|Actinobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
TLS2_k127_3745155_3	1229780.BN381_170038	1.154e-46	183.0	2C2HI@1|root,345RC@2|Bacteria,2H8AE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3745155_6	351607.Acel_0901	6.719e-39	154.0	COG1579@1|root,COG1579@2|Bacteria,2GP84@201174|Actinobacteria,4ESKG@85013|Frankiales	201174|Actinobacteria	S	C4-type zinc ribbon domain	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
TLS2_k127_3745155_7	1229780.BN381_330122	3.237e-31	128.0	COG1051@1|root,COG1051@2|Bacteria,2ISCR@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_3745155_2	1229780.BN381_330121	8.374e-64	227.0	COG0483@1|root,COG0483@2|Bacteria	2|Bacteria	G	inositol monophosphate 1-phosphatase activity	-	-	3.1.3.25,3.1.3.7	ko:K01082,ko:K01092	ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070	M00131	R00188,R00508,R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Inositol_P
TLS2_k127_3745155_5	1121937.AUHJ01000003_gene3225	1.217e-43	171.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,465EN@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	5TM-5TMR_LYT,CHASE5,CheB_methylest,CheR,CheR_N,EAL,GGDEF,PAS,PAS_4,PAS_9,Response_reg
TLS2_k127_3745155_1	926560.KE387023_gene2049	9.014e-71	262.0	COG5001@1|root,COG5001@2|Bacteria,1WK20@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4
TLS2_k127_3759185_13	1121924.ATWH01000007_gene1993	1.893e-56	206.0	COG1718@1|root,COG1718@2|Bacteria,2GM3J@201174|Actinobacteria,4FN3V@85023|Microbacteriaceae	201174|Actinobacteria	DT	RIO1 family	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
TLS2_k127_3759185_5	1380347.JNII01000007_gene500	3.014e-100	338.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4EU25@85013|Frankiales	201174|Actinobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
TLS2_k127_3759185_11	101510.RHA1_ro02950	1.776e-66	233.0	COG1309@1|root,COG1309@2|Bacteria,2GV75@201174|Actinobacteria,4FX2S@85025|Nocardiaceae	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
TLS2_k127_3759185_15	110319.CF8_4127	2.389e-35	144.0	COG2188@1|root,COG2188@2|Bacteria,2IJQP@201174|Actinobacteria	201174|Actinobacteria	K	UTRA domain	-	-	-	ko:K02043	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS2_k127_3759185_4	365046.Rta_21660	3.562e-105	359.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHVF@28216|Betaproteobacteria,4ACGU@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TLS2_k127_3759185_17	1229203.KI301992_gene302	1.329e-32	143.0	COG3509@1|root,COG3509@2|Bacteria,2IGF9@201174|Actinobacteria,3UXN5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	Q	Esterase PHB depolymerase	lpqC	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase,Esterase_phd
TLS2_k127_3759185_22	1120917.AQXM01000062_gene1986	1.016e-15	89.0	2EGCD@1|root,33A46@2|Bacteria,2HTN8@201174|Actinobacteria,1WBWQ@1268|Micrococcaceae	201174|Actinobacteria	S	Septum formation	-	-	-	-	-	-	-	-	-	-	-	-	Septum_form
TLS2_k127_3759185_25	1219072.VHA01S_008_00980	6.405e-06	56.0	COG0296@1|root,COG0296@2|Bacteria,1N8WX@1224|Proteobacteria,1S8R5@1236|Gammaproteobacteria,1Y291@135623|Vibrionales	135623|Vibrionales	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
TLS2_k127_3759185_3	477641.MODMU_1850	4.555e-126	417.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4EUKK@85013|Frankiales	201174|Actinobacteria	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_3759185_23	285535.JOEY01000007_gene8539	3.252e-14	83.0	COG3595@1|root,COG3595@2|Bacteria,2I8IR@201174|Actinobacteria	201174|Actinobacteria	T	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_3759185_9	345341.KUTG_09157	3.854e-73	258.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,2GJDX@201174|Actinobacteria,4E0GC@85010|Pseudonocardiales	201174|Actinobacteria	P	Catalyzes the synthesis of activated sulfate	cysN	GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006793,GO:0006796,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:0071944,GO:1902494,GO:1902503,GO:1990234	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
TLS2_k127_3759185_8	1476583.DEIPH_ctg047orf0003	3.994e-85	292.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
TLS2_k127_3759185_20	1206741.BAFX01000130_gene1982	1.388e-19	97.0	COG1309@1|root,COG1309@2|Bacteria,2GV75@201174|Actinobacteria,4FX2S@85025|Nocardiaceae	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
TLS2_k127_3759185_19	1380356.JNIK01000011_gene1752	1.258e-19	102.0	COG4339@1|root,COG4339@2|Bacteria,2IQ60@201174|Actinobacteria,4ETC4@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF4031)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4031
TLS2_k127_3759185_12	446462.Amir_4672	7.188e-62	226.0	COG2843@1|root,COG2843@2|Bacteria,2GP72@201174|Actinobacteria,4E1BJ@85010|Pseudonocardiales	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
TLS2_k127_3759185_24	1304865.JAGF01000001_gene2884	2.41e-13	82.0	COG5602@1|root,COG5602@2|Bacteria	2|Bacteria	B	histone deacetylation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3759185_21	525244.HMPREF0023_0995	4.328e-16	91.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,3NIKG@468|Moraxellaceae	1236|Gammaproteobacteria	O	Belongs to the peptidase S1C family	mucD	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_3759185_2	1043205.AFYF01000051_gene3051	1.235e-130	447.0	COG0471@1|root,COG0471@2|Bacteria,2HXIC@201174|Actinobacteria,4FH0P@85021|Intrasporangiaceae	201174|Actinobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
TLS2_k127_3759185_14	1313172.YM304_09520	4.873e-51	193.0	COG1695@1|root,COG1695@2|Bacteria,2GNA1@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
TLS2_k127_3759185_7	1313172.YM304_09530	3.273e-86	293.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CNT1@84992|Acidimicrobiia	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3759185_10	1313172.YM304_09540	3.691e-70	269.0	COG4591@1|root,COG4591@2|Bacteria,2I445@201174|Actinobacteria	201174|Actinobacteria	M	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
TLS2_k127_3759185_0	1313172.YM304_41670	4.688e-240	764.0	COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria	201174|Actinobacteria	Q	N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_3759185_16	1032480.MLP_24830	3.659e-34	138.0	COG1595@1|root,COG1595@2|Bacteria,2HG34@201174|Actinobacteria,4DWA5@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_3759185_18	932677.PAJ_2110	3.912e-26	122.0	COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,1S8XH@1236|Gammaproteobacteria,3W120@53335|Pantoea	1236|Gammaproteobacteria	P	arsenate reductase	arsC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
TLS2_k127_3759185_6	1172180.KB911800_gene3296	2.181e-95	327.0	COG2321@1|root,COG2321@2|Bacteria,2H3UT@201174|Actinobacteria	201174|Actinobacteria	S	Neutral zinc metallopeptidase	ypfJ	GO:0005575,GO:0005576	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
TLS2_k127_3759185_1	525909.Afer_1846	7.655e-170	539.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4CNG0@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS2_k127_3794393_23	1123320.KB889674_gene4179	3.359e-05	51.0	2EMGF@1|root,33F55@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3794393_4	1211815.CBYP010000067_gene129	1.419e-155	503.0	COG1960@1|root,COG1960@2|Bacteria,2GJDT@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3794393_15	1123321.KB905813_gene1323	4.785e-65	234.0	COG1946@1|root,COG1946@2|Bacteria,2GJ1B@201174|Actinobacteria	201174|Actinobacteria	I	Acyl-CoA thioesterase	tesB	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
TLS2_k127_3794393_11	1283299.AUKG01000001_gene1973	5.735e-75	263.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4CP8R@84995|Rubrobacteria	84995|Rubrobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
TLS2_k127_3794393_9	1229780.BN381_150108	1.708e-88	297.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574,ko:K06889	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS2_k127_3794393_3	1313172.YM304_04990	3.473e-201	651.0	COG2844@1|root,COG2844@2|Bacteria,2GMKT@201174|Actinobacteria	201174|Actinobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
TLS2_k127_3794393_5	223184.AS25_08510	3.393e-148	487.0	COG0446@1|root,COG0446@2|Bacteria,2H7WY@201174|Actinobacteria,1W8BY@1268|Micrococcaceae	201174|Actinobacteria	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_3794393_24	1229780.BN381_210073	3.926e-05	48.0	2FF8Q@1|root,3476J@2|Bacteria,2H7PN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3794393_0	1122138.AQUZ01000002_gene2100	5.804e-282	887.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4DQ5C@85009|Propionibacteriales	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS2_k127_3794393_20	585531.HMPREF0063_12827	1.201e-27	114.0	COG2388@1|root,COG2388@2|Bacteria,2GQNP@201174|Actinobacteria,4DSKE@85009|Propionibacteriales	201174|Actinobacteria	S	GCN5-related N-acetyl-transferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
TLS2_k127_3794393_12	675635.Psed_1615	1.298e-73	259.0	COG1606@1|root,COG1606@2|Bacteria,2GPA1@201174|Actinobacteria,4E2I7@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM ExsB family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase,QueC
TLS2_k127_3794393_10	1122609.AUGT01000030_gene2524	3.395e-80	290.0	COG2872@1|root,COG2872@2|Bacteria,2I8P6@201174|Actinobacteria	201174|Actinobacteria	S	Threonyl alanyl tRNA synthetase SAD	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
TLS2_k127_3794393_18	512565.AMIS_53140	1.11e-34	156.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4D9AS@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,TPR_12,Trans_reg_C
TLS2_k127_3794393_7	1121377.KB906404_gene2877	1.341e-90	340.0	COG0515@1|root,COG0515@2|Bacteria,1WIDK@1297|Deinococcus-Thermus	1121377.KB906404_gene2877|-	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3794393_1	1313172.YM304_38870	1.993e-211	691.0	COG1033@1|root,COG1033@2|Bacteria,2I731@201174|Actinobacteria	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_3794393_19	463191.SSEG_08439	4.641e-32	134.0	COG0011@1|root,COG0011@2|Bacteria,2IQ7E@201174|Actinobacteria	201174|Actinobacteria	S	Thiamine-binding protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
TLS2_k127_3794393_17	1082931.KKY_3005	5.641e-47	188.0	COG3883@1|root,COG3883@2|Bacteria	2|Bacteria	S	cell wall organization	-	-	2.1.1.80,3.1.1.61	ko:K10541,ko:K13924	ko02010,ko02020,ko02030,map02010,map02020,map02030	M00214,M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko02022,ko02035	3.A.1.2.3	-	-	BPD_transp_2,DUF3450
TLS2_k127_3794393_21	314265.R2601_20706	6.803e-19	101.0	COG2340@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria,1R62B@1224|Proteobacteria,2U3MK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,HemolysinCabind
TLS2_k127_3794393_14	690850.Desaf_3070	1.191e-69	256.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,DUF2048,Peptidase_S9
TLS2_k127_3794393_13	926549.KI421517_gene3383	1.15e-71	256.0	COG1506@1|root,COG1506@2|Bacteria,4PKHC@976|Bacteroidetes,47YF6@768503|Cytophagia	976|Bacteroidetes	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
TLS2_k127_3794393_16	477641.MODMU_0886	1.173e-50	194.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria,4ETC8@85013|Frankiales	201174|Actinobacteria	CP	ABC-2 family transporter protein	yhaP	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_3794393_8	1386089.N865_11920	1.226e-88	302.0	COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria,4FEGG@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_3794393_2	1211815.CBYP010000067_gene115	1.947e-208	654.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4ETRJ@85013|Frankiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	fadE1_1	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3794393_6	1123024.AUII01000006_gene4534	1.455e-99	342.0	COG0683@1|root,COG0683@2|Bacteria,2GM00@201174|Actinobacteria,4E1CX@85010|Pseudonocardiales	201174|Actinobacteria	E	ABC-type branched-chain amino acid transport	livK	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_3797201_14	935866.JAER01000040_gene521	2.672e-26	116.0	COG0835@1|root,COG0835@2|Bacteria,2IQJ0@201174|Actinobacteria,4DUIU@85009|Propionibacteriales	201174|Actinobacteria	NT	Two component signalling adaptor domain	cheW	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
TLS2_k127_3797201_17	1146883.BLASA_1468	7.525e-09	70.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	sgaR	-	-	ko:K02479,ko:K07684,ko:K07685	ko02020,map02020	M00471,M00472	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
TLS2_k127_3797201_1	1229780.BN381_130124	6.759e-221	698.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,3UW6I@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
TLS2_k127_3797201_8	1313172.YM304_33030	8.503e-87	294.0	COG0084@1|root,COG0084@2|Bacteria,2GMJJ@201174|Actinobacteria,4CN2X@84992|Acidimicrobiia	84992|Acidimicrobiia	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
TLS2_k127_3797201_16	882086.SacxiDRAFT_4298	1.025e-11	76.0	COG3409@1|root,COG3409@2|Bacteria,2ICQE@201174|Actinobacteria,4E2KH@85010|Pseudonocardiales	201174|Actinobacteria	M	Transglycosylase-like domain	-	-	-	ko:K21687	-	-	-	-	ko00000	-	GH23	-	PG_binding_1,Transglycosylas
TLS2_k127_3797201_9	1313172.YM304_33050	1.146e-81	283.0	COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria,4CN5A@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	-	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TLS2_k127_3797201_4	1333998.M2A_1982	1.075e-124	407.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2TQUY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_3797201_7	1229780.BN381_20098	9.502e-91	308.0	COG1947@1|root,COG1947@2|Bacteria,2GKXD@201174|Actinobacteria,3UWNZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0040007,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_3797201_18	1229780.BN381_20100	0.0008731	44.0	COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria,3UW77@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
TLS2_k127_3797201_2	1172188.KB911820_gene2749	5.507e-184	580.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,4FEE3@85021|Intrasporangiaceae	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	ko:K18369	ko00640,map00640	-	R10703	RC00545	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
TLS2_k127_3797201_6	643648.Slip_0104	8.068e-91	311.0	COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,42JPG@68298|Syntrophomonadaceae	186801|Clostridia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
TLS2_k127_3797201_3	1229780.BN381_20100	3.239e-139	449.0	COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria,3UW77@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
TLS2_k127_3797201_11	1313172.YM304_33100	2.21e-46	175.0	COG1825@1|root,COG1825@2|Bacteria,2GJPJ@201174|Actinobacteria,4CNB1@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	rplY	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
TLS2_k127_3797201_10	1229780.BN381_20103	7.681e-65	228.0	COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria,3UWQE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
TLS2_k127_3797201_0	469371.Tbis_3135	0.0	1040.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4DXZU@85010|Pseudonocardiales	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS2_k127_3797201_13	649638.Trad_0014	2.158e-28	127.0	COG0760@1|root,COG0760@2|Bacteria,1WJ16@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N_3
TLS2_k127_3797201_5	1313172.YM304_33140	5.629e-117	396.0	COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria,4CN31@84992|Acidimicrobiia	84992|Acidimicrobiia	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	ko:K02499	-	-	-	-	ko00000,ko03036	-	-	-	MazG
TLS2_k127_3797201_15	314265.R2601_19005	9.331e-18	97.0	COG2340@1|root,COG2374@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2374@2|Bacteria,COG2931@2|Bacteria,1R62B@1224|Proteobacteria,2U3MK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,HemolysinCabind
TLS2_k127_3797201_12	1173021.ALWA01000022_gene618	2.76e-45	182.0	2DKYJ@1|root,30WNV@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF1996)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1996
TLS2_k127_3799519_9	314256.OG2516_05293	3.269e-06	57.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2TUUZ@28211|Alphaproteobacteria,2PCH4@252301|Oceanicola	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigH	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_3799519_5	298654.FraEuI1c_1587	3.289e-68	241.0	COG2207@1|root,COG2207@2|Bacteria,2IT46@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS2_k127_3799519_7	298654.FraEuI1c_1588	1.277e-48	176.0	COG3324@1|root,COG3324@2|Bacteria,2GSUY@201174|Actinobacteria	201174|Actinobacteria	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_3799519_6	42256.RradSPS_0328	4.546e-68	257.0	COG2202@1|root,COG2203@1|root,COG2208@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,2GKEF@201174|Actinobacteria,4CU1G@84995|Rubrobacteria	84995|Rubrobacteria	T	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,PAS_9,SpoIIE
TLS2_k127_3799519_8	1828.JOKB01000035_gene690	1.027e-07	61.0	COG2197@1|root,COG2197@2|Bacteria,2GJ9U@201174|Actinobacteria,4FX62@85025|Nocardiaceae	201174|Actinobacteria	T	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	ko:K07693	ko02020,map02020	M00479	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
TLS2_k127_3799519_2	1229780.BN381_250030	2.222e-189	663.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,3UX9I@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_3799519_3	436229.JOEH01000027_gene2231	3.458e-111	366.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,2NHMV@228398|Streptacidiphilus	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3799519_1	1229780.BN381_60023	4.774e-210	696.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,3UXGT@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
TLS2_k127_3799519_0	886293.Sinac_1560	5.041e-263	822.0	COG1132@1|root,COG1132@2|Bacteria,2IYCU@203682|Planctomycetes	2|Bacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
TLS2_k127_3799519_4	1237500.ANBA01000002_gene5699	1.659e-109	368.0	COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_3804362_1	1313172.YM304_15410	4.482e-172	557.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CMTJ@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_3804362_2	1435356.Y013_12475	6.027e-129	421.0	COG2141@1|root,COG2141@2|Bacteria,2GN4N@201174|Actinobacteria,4G8SR@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_3804362_3	1313172.YM304_16660	5.354e-72	258.0	COG0778@1|root,COG0778@2|Bacteria,2HI8Q@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_3804362_0	58123.JOFJ01000004_gene1813	0.0	1423.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4EGYX@85012|Streptosporangiales	201174|Actinobacteria	E	Bacterial NAD-glutamate dehydrogenase	gdh	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
TLS2_k127_3804362_4	1240349.ANGC01000007_gene1210	5.395e-18	88.0	COG3663@1|root,COG3663@2|Bacteria,2GNS5@201174|Actinobacteria,4FW6C@85025|Nocardiaceae	201174|Actinobacteria	L	Uracil DNA glycosylase superfamily	mug	-	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_3837556_4	749927.AMED_5545	9.042e-68	238.0	COG0654@1|root,COG0654@2|Bacteria,2GK7I@201174|Actinobacteria,4DXC9@85010|Pseudonocardiales	201174|Actinobacteria	CH	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_binding_3,FAD_oxidored
TLS2_k127_3837556_3	1206744.BAGL01000033_gene170	2.135e-86	295.0	COG0596@1|root,COG0596@2|Bacteria,2I2VI@201174|Actinobacteria,4G9U0@85025|Nocardiaceae	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_3837556_0	471852.Tcur_2984	3.552e-186	610.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Abhydrolase_1,GerE,Trans_reg_C
TLS2_k127_3837556_2	1348663.KCH_40700	1.495e-96	335.0	COG2141@1|root,COG2141@2|Bacteria,2GJI7@201174|Actinobacteria,2M1SU@2063|Kitasatospora	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_3837556_11	1463921.JODF01000098_gene1178	2.903e-22	104.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_3837556_9	1455608.JDTH01000002_gene583	2.005e-41	159.0	COG4329@1|root,arCOG10734@2157|Archaea,2XX7M@28890|Euryarchaeota,23VSY@183963|Halobacteria	183963|Halobacteria	S	Predicted membrane protein (DUF2243)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2243
TLS2_k127_3837556_8	405948.SACE_4177	2.669e-42	165.0	COG5592@1|root,COG5592@2|Bacteria,2HF5Y@201174|Actinobacteria,4E645@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS2_k127_3837556_5	402881.Plav_3287	1.188e-51	186.0	COG2323@1|root,COG2323@2|Bacteria,1RATW@1224|Proteobacteria,2UBAK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
TLS2_k127_3837556_12	882082.SaccyDRAFT_2726	2.033e-17	95.0	2C3FA@1|root,32Y72@2|Bacteria,2GUDR@201174|Actinobacteria,4E7S5@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3837556_10	590998.Celf_0114	8.675e-29	128.0	COG4978@1|root,COG4978@2|Bacteria,2IQMV@201174|Actinobacteria,4F2Q6@85016|Cellulomonadaceae	201174|Actinobacteria	KT	Bacterial transcription activator, effector binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
TLS2_k127_3837556_7	105422.BBPM01000058_gene4566	1.625e-49	192.0	COG1309@1|root,COG1309@2|Bacteria,2IJTA@201174|Actinobacteria,2NKZ9@228398|Streptacidiphilus	201174|Actinobacteria	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TLS2_k127_3837556_13	1157638.KB892209_gene1052	8.131e-15	87.0	2F9XM@1|root,34270@2|Bacteria,2IRKQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3837556_14	1540221.JQNI01000002_gene1339	4.913e-05	56.0	COG5504@1|root,COG5504@2|Bacteria	2|Bacteria	O	Zn-dependent protease	gldB	-	-	-	-	-	-	-	-	-	-	-	DUF2268
TLS2_k127_3837556_6	926560.KE387023_gene1920	5.652e-50	203.0	COG2374@1|root,COG2374@2|Bacteria,1WM95@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	U	PFAM Endonuclease Exonuclease phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Exo_endo_phos,LTD
TLS2_k127_3837556_1	1121926.AXWO01000013_gene2076	6.649e-168	556.0	COG2374@1|root,COG2374@2|Bacteria,2HZ1P@201174|Actinobacteria,4EZBW@85014|Glycomycetales	201174|Actinobacteria	S	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3850262_6	1229780.BN381_310060	5.998e-126	413.0	COG1104@1|root,COG1104@2|Bacteria,2GKUT@201174|Actinobacteria,3UWEF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Aminotransferase class-V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS2_k127_3850262_25	1463825.JNXC01000001_gene5723	1.199e-31	138.0	COG3764@1|root,COG3764@2|Bacteria,2I91T@201174|Actinobacteria,4E4HH@85010|Pseudonocardiales	201174|Actinobacteria	M	Sortase family	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
TLS2_k127_3850262_20	367299.JOEE01000001_gene1668	1.017e-50	191.0	arCOG06227@1|root,2ZCRG@2|Bacteria,2I96P@201174|Actinobacteria,4FE9G@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
TLS2_k127_3850262_28	1313172.YM304_09680	3.832e-26	113.0	COG2062@1|root,COG2062@2|Bacteria	2|Bacteria	T	phosphohistidine phosphatase, SixA	sixA	-	3.6.1.55	ko:K03574,ko:K08296	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
TLS2_k127_3850262_37	283165.BQ03960	2.492e-12	73.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2U96P@28211|Alphaproteobacteria,48U3D@772|Bartonellaceae	28211|Alphaproteobacteria	P	subunit of a heme lyase	cycL	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
TLS2_k127_3850262_22	1229780.BN381_310055	4.827e-42	164.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_3850262_1	1229780.BN381_310054	1.372e-251	797.0	COG1138@1|root,COG1138@2|Bacteria,2HZM9@201174|Actinobacteria	201174|Actinobacteria	O	Cytochrome c-type biogenesis protein CcmF	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
TLS2_k127_3850262_29	1229780.BN381_310053	8.2e-25	119.0	COG2332@1|root,COG2332@2|Bacteria,2GZPB@201174|Actinobacteria	201174|Actinobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
TLS2_k127_3850262_19	1313172.YM304_09620	2.718e-51	195.0	COG0755@1|root,COG0755@2|Bacteria,2IIHK@201174|Actinobacteria,4CN1E@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Cytochrome C assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
TLS2_k127_3850262_18	1313172.YM304_09610	4.542e-55	202.0	COG2386@1|root,COG2386@2|Bacteria,2HG7F@201174|Actinobacteria,4CN4H@84992|Acidimicrobiia	84992|Acidimicrobiia	O	CcmB protein	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
TLS2_k127_3850262_14	1229780.BN381_310049	3.848e-80	274.0	COG1131@1|root,COG1131@2|Bacteria,2IRXJ@201174|Actinobacteria	201174|Actinobacteria	V	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
TLS2_k127_3850262_21	1229780.BN381_310048	1.76e-44	176.0	COG3764@1|root,COG3764@2|Bacteria,2GKT6@201174|Actinobacteria,3UXMS@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Evidence 5 No homology to any previously reported sequences	srtB	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
TLS2_k127_3850262_35	888050.HMPREF9004_0722	2.562e-13	83.0	2EGCD@1|root,33A46@2|Bacteria,2I66V@201174|Actinobacteria,4D5QZ@85005|Actinomycetales	201174|Actinobacteria	S	Septum formation	-	-	-	-	-	-	-	-	-	-	-	-	Septum_form
TLS2_k127_3850262_38	1229780.BN381_310047	1.298e-10	73.0	2EGCD@1|root,33A46@2|Bacteria,2HZ83@201174|Actinobacteria,3UWYF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Septum formation	-	-	-	-	-	-	-	-	-	-	-	-	Septum_form
TLS2_k127_3850262_27	416591.Tlet_0082	1.88e-26	122.0	COG0438@1|root,COG0438@2|Bacteria,2GC8C@200918|Thermotogae	200918|Thermotogae	M	PFAM glycosyl transferase group 1	mggS	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_3850262_9	1048339.KB913029_gene1545	3.475e-109	366.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_3850262_33	1176165.CAJD01000019_gene1436	1.716e-17	90.0	COG1309@1|root,COG1309@2|Bacteria,2GVM5@201174|Actinobacteria,4F9XB@85019|Brevibacteriaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_3850262_8	1380390.JIAT01000011_gene2646	7.347e-118	396.0	COG0147@1|root,COG0147@2|Bacteria,2GN7D@201174|Actinobacteria,4CQAQ@84995|Rubrobacteria	84995|Rubrobacteria	EH	chorismate binding enzyme	-	-	2.6.1.85,4.1.3.38	ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4,Chorismate_bind
TLS2_k127_3850262_39	468556.AQYG01000051_gene2356	1.457e-09	65.0	COG3237@1|root,COG3237@2|Bacteria,2GQUI@201174|Actinobacteria,4GF74@85026|Gordoniaceae	201174|Actinobacteria	S	CsbD-like	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
TLS2_k127_3850262_13	1229780.BN381_410016	3.838e-81	280.0	COG1946@1|root,COG1946@2|Bacteria,2GJ1B@201174|Actinobacteria,3UWQF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Acyl-CoA thioesterase	-	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
TLS2_k127_3850262_24	1283283.ATXA01000015_gene85	1.948e-36	154.0	COG1403@1|root,COG1403@2|Bacteria,2HAHI@201174|Actinobacteria,4ESDB@85013|Frankiales	201174|Actinobacteria	L	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_3850262_2	1313172.YM304_34780	5.151e-211	661.0	COG1960@1|root,COG1960@2|Bacteria,2GNTA@201174|Actinobacteria,4CMRQ@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3850262_7	1121877.JQKF01000016_gene125	5.205e-125	434.0	COG0215@1|root,COG0215@2|Bacteria,2GJF2@201174|Actinobacteria,4CMTW@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
TLS2_k127_3850262_34	1266908.AQPB01000042_gene1064	4.009e-17	93.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1SYRX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Protoglobin
TLS2_k127_3850262_0	298654.FraEuI1c_2263	0.0	1085.0	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4ERSS@85013|Frankiales	201174|Actinobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
TLS2_k127_3850262_10	1313172.YM304_22030	1.38e-97	331.0	COG0668@1|root,COG0668@2|Bacteria,2GMFK@201174|Actinobacteria	201174|Actinobacteria	M	mechanosensitive ion channel	mscS	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
TLS2_k127_3850262_16	525909.Afer_0762	1.618e-72	261.0	COG0740@1|root,COG0740@2|Bacteria,2GKNK@201174|Actinobacteria,4CMUY@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TLS2_k127_3850262_40	1133849.O3I_018650	7.772e-06	53.0	COG3832@1|root,COG3832@2|Bacteria,2ISCU@201174|Actinobacteria,4G1QF@85025|Nocardiaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_3850262_31	443255.SCLAV_4446	3.123e-20	103.0	COG0640@1|root,COG0640@2|Bacteria,2IKWF@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_3850262_23	1283300.ATXB01000002_gene2833	5.456e-42	171.0	COG3461@1|root,COG3461@2|Bacteria,1MZZN@1224|Proteobacteria,1S688@1236|Gammaproteobacteria,1XFTT@135618|Methylococcales	135618|Methylococcales	S	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K09700	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_3850262_11	1380391.JIAS01000011_gene5458	2.227e-93	322.0	COG1659@1|root,COG1659@2|Bacteria,1QKHQ@1224|Proteobacteria,2TUWD@28211|Alphaproteobacteria,2JR8W@204441|Rhodospirillales	204441|Rhodospirillales	S	Encapsulating protein for peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	Linocin_M18
TLS2_k127_3850262_4	1313172.YM304_21470	1.871e-140	460.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4CN10@84992|Acidimicrobiia	201174|Actinobacteria	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_3850262_5	1313172.YM304_21460	5.901e-136	446.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4CN10@84992|Acidimicrobiia	201174|Actinobacteria	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_3850262_12	1211815.CBYP010000014_gene3514	5.769e-84	290.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027,ko:K20468	-	-	-	-	ko00000,ko02000	4.D.2,4.D.2.4.1	-	-	LPG_synthase_TM
TLS2_k127_3850262_3	1211815.CBYP010000068_gene194	4.754e-186	616.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_3850262_26	656024.FsymDg_3236	7.626e-27	123.0	COG1309@1|root,COG1309@2|Bacteria,2I9NV@201174|Actinobacteria,4EW00@85013|Frankiales	201174|Actinobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
TLS2_k127_3850262_32	452652.KSE_33210	5.309e-18	89.0	2EGDD@1|root,33A58@2|Bacteria,2GR3X@201174|Actinobacteria,2M3K6@2063|Kitasatospora	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
TLS2_k127_3850262_15	1429916.X566_19625	1.234e-78	271.0	COG0300@1|root,COG0300@2|Bacteria,1R25N@1224|Proteobacteria,2TZB2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_3850262_17	1313172.YM304_39910	1.409e-67	246.0	COG0715@1|root,COG0715@2|Bacteria,2I93G@201174|Actinobacteria	201174|Actinobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TLS2_k127_3853028_8	1229780.BN381_80292	5.817e-49	193.0	COG3346@1|root,COG3346@2|Bacteria,2GR90@201174|Actinobacteria,3UWY7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	SURF1 family	-	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	SURF1
TLS2_k127_3853028_6	369723.Strop_4194	1.009e-89	309.0	COG1162@1|root,COG1162@2|Bacteria,2GMDX@201174|Actinobacteria,4DBP0@85008|Micromonosporales	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
TLS2_k127_3853028_11	644283.Micau_1024	8.123e-11	71.0	COG2177@1|root,COG2177@2|Bacteria,2GJMA@201174|Actinobacteria,4D9UH@85008|Micromonosporales	201174|Actinobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
TLS2_k127_3853028_0	1313172.YM304_16240	8.942e-258	806.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4CNF1@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_3853028_1	1246448.ANAZ01000019_gene969	3.826e-145	479.0	COG2197@1|root,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE,TPR_19
TLS2_k127_3853028_9	1246448.ANAZ01000019_gene968	2.941e-28	121.0	COG1765@1|root,COG1765@2|Bacteria,2IG8A@201174|Actinobacteria,4EKV5@85012|Streptosporangiales	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_3853028_2	1246448.ANAZ01000019_gene967	3.608e-137	454.0	COG2230@1|root,COG2230@2|Bacteria,2H060@201174|Actinobacteria	201174|Actinobacteria	M	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_3853028_5	765420.OSCT_1426	1.326e-95	332.0	COG1126@1|root,COG1126@2|Bacteria,2G5UB@200795|Chloroflexi,376F8@32061|Chloroflexia	32061|Chloroflexia	E	PFAM ABC transporter related	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
TLS2_k127_3853028_7	1128421.JAGA01000003_gene3360	1.183e-66	238.0	COG0765@1|root,COG0765@2|Bacteria,2NPKZ@2323|unclassified Bacteria	2|Bacteria	E	Binding-protein-dependent transport system inner membrane component	yxeN	-	3.4.15.5	ko:K01284,ko:K02029	-	M00236	-	-	ko00000,ko00002,ko01000,ko01002,ko02000	3.A.1.3	-	-	BPD_transp_1
TLS2_k127_3853028_4	926569.ANT_12150	2.738e-101	340.0	COG0834@1|root,COG0834@2|Bacteria,2G6HE@200795|Chloroflexi	200795|Chloroflexi	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
TLS2_k127_3853028_3	1229780.BN381_330092	7.026e-105	346.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,3UWJR@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
TLS2_k127_3853028_12	1347368.HG964404_gene5150	0.000729	44.0	COG1051@1|root,COG1051@2|Bacteria,1V6ZQ@1239|Firmicutes,4HIQM@91061|Bacilli,1ZIC1@1386|Bacillus	91061|Bacilli	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_3865457_35	1229780.BN381_130338	2.963e-23	113.0	COG2852@1|root,COG2852@2|Bacteria	2|Bacteria	L	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4,DUF559
TLS2_k127_3865457_9	1429046.RR21198_2010	8.316e-107	358.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4FW36@85025|Nocardiaceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	livF	-	-	ko:K01995,ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_3865457_5	1137271.AZUM01000002_gene2148	1.517e-121	395.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4E9B4@85010|Pseudonocardiales	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_3865457_11	358823.DF19_13310	5.016e-102	341.0	COG4177@1|root,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_3865457_7	1043205.AFYF01000075_gene2078	3.944e-111	374.0	COG0559@1|root,COG0559@2|Bacteria,2GMAY@201174|Actinobacteria,4FFXG@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K11956	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	BPD_transp_2,CarboxypepD_reg
TLS2_k127_3865457_16	1229780.BN381_150097	5.532e-86	291.0	COG3253@1|root,COG3253@2|Bacteria	2|Bacteria	S	peroxidase activity	ywfI	-	-	ko:K00435	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R11522	RC00884	ko00000,ko00001,ko01000	-	-	-	Chlor_dismutase
TLS2_k127_3865457_1	383372.Rcas_4386	1.014e-245	794.0	COG0243@1|root,COG0243@2|Bacteria,2G7V5@200795|Chloroflexi,375JH@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
TLS2_k127_3865457_22	591158.SSMG_05327	5.523e-63	232.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria	201174|Actinobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
TLS2_k127_3865457_8	1313172.YM304_36700	1.023e-107	357.0	COG0208@1|root,COG0208@2|Bacteria,2GKGZ@201174|Actinobacteria	201174|Actinobacteria	F	PFAM Fatty acid desaturase, type 2	desA	-	1.14.19.11,1.14.19.2,1.14.19.26	ko:K03921	ko00061,ko01040,ko01212,map00061,map01040,map01212	-	R03370,R08161,R11108,R11109	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase_2
TLS2_k127_3865457_17	1229780.BN381_450035	1.75e-79	274.0	COG1028@1|root,COG1028@2|Bacteria,2GMG3@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_3865457_36	1313172.YM304_11260	2.658e-22	102.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r4_2
TLS2_k127_3865457_2	1122138.AQUZ01000016_gene165	2.12e-245	786.0	COG1770@1|root,COG1770@2|Bacteria,2GNA9@201174|Actinobacteria,4DNHX@85009|Propionibacteriales	201174|Actinobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_3865457_20	1089544.KB912942_gene2674	1.523e-71	254.0	COG1878@1|root,COG1878@2|Bacteria,2GJ59@201174|Actinobacteria	201174|Actinobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_3865457_42	1246626.BleG1_3222	6.472e-06	55.0	COG2172@1|root,COG2172@2|Bacteria,1V1IA@1239|Firmicutes,4HFPF@91061|Bacilli,1ZF6G@1386|Bacillus	91061|Bacilli	T	Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)	rsbW	GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
TLS2_k127_3865457_28	1313172.YM304_38230	3.01e-53	192.0	COG0756@1|root,COG0756@2|Bacteria,2IHYY@201174|Actinobacteria,4CN99@84992|Acidimicrobiia	84992|Acidimicrobiia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
TLS2_k127_3865457_19	1313172.YM304_38580	1.938e-72	249.0	COG1949@1|root,COG1949@2|Bacteria,2GJR7@201174|Actinobacteria,4CN0M@84992|Acidimicrobiia	84992|Acidimicrobiia	L	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	-	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
TLS2_k127_3865457_14	1313172.YM304_41440	8.333e-95	324.0	COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4CNYR@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_3865457_29	1313172.YM304_21930	3.397e-51	191.0	COG3884@1|root,COG3884@2|Bacteria,2H0CD@201174|Actinobacteria,4CNBC@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-ACP thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-ACP_TE
TLS2_k127_3865457_32	1229780.BN381_450041	4.087e-31	132.0	2DMIS@1|root,32RVG@2|Bacteria,2IQ99@201174|Actinobacteria	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB7	GO:0001101,GO:0008150,GO:0010033,GO:0033993,GO:0042221,GO:0046677,GO:0050896,GO:0070542,GO:1901700	-	ko:K18958	-	-	-	-	ko00000,ko03000	-	-	-	AT_hook,Whib
TLS2_k127_3865457_39	357809.Cphy_0735	1.223e-17	96.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,25B5Z@186801|Clostridia,2244Y@1506553|Lachnoclostridium	186801|Clostridia	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD,Redoxin
TLS2_k127_3865457_24	1048339.KB913029_gene2808	3.759e-59	218.0	COG0785@1|root,COG0785@2|Bacteria,2I8T6@201174|Actinobacteria,4EVDM@85013|Frankiales	201174|Actinobacteria	O	Cytochrome c biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
TLS2_k127_3865457_4	644283.Micau_4756	1.944e-146	478.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4D9KK@85008|Micromonosporales	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	1.14.14.5	ko:K04091	ko00920,map00920	-	R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
TLS2_k127_3865457_21	1128421.JAGA01000002_gene1529	3.519e-68	240.0	COG0259@1|root,COG0259@2|Bacteria,2NQT9@2323|unclassified Bacteria	2|Bacteria	H	Pfam:PNPOx_C	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.pdxH	PNP_phzG_C,Putative_PNPOx
TLS2_k127_3865457_15	1229780.BN381_300038	5.474e-91	311.0	COG1732@1|root,COG1732@2|Bacteria,2GJWY@201174|Actinobacteria,3UXDP@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	of an ABC-type transport system	-	-	-	-	-	-	-	-	-	-	-	-	OpuAC
TLS2_k127_3865457_25	1157637.KB892094_gene3058	1.993e-58	220.0	COG1174@1|root,COG1174@2|Bacteria,2GYTC@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter (Permease)	proW	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
TLS2_k127_3865457_26	1229780.BN381_300040	4.547e-58	214.0	COG1174@1|root,COG1174@2|Bacteria,2GMU0@201174|Actinobacteria,3UXGB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
TLS2_k127_3865457_10	1089552.KI911559_gene1301	1.106e-105	355.0	COG1125@1|root,COG1125@2|Bacteria,1QTUC@1224|Proteobacteria,2TTMA@28211|Alphaproteobacteria,2JRKI@204441|Rhodospirillales	204441|Rhodospirillales	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,CBS
TLS2_k127_3865457_3	1229780.BN381_450047	3.64e-162	520.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,3UWDU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TLS2_k127_3865457_23	365528.KB891219_gene1067	1.661e-61	226.0	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria,4ESTT@85013|Frankiales	201174|Actinobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
TLS2_k127_3865457_13	1229780.BN381_450049	1.517e-100	340.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,3UX8B@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	drrA_2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3865457_38	1313172.YM304_38650	1.538e-18	96.0	2A8HP@1|root,30XJU@2|Bacteria,2HB16@201174|Actinobacteria	201174|Actinobacteria	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
TLS2_k127_3865457_18	1229780.BN381_450052	3.188e-79	273.0	COG1845@1|root,COG1845@2|Bacteria,2GKK8@201174|Actinobacteria,3UWIY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Cytochrome c oxidase subunit III	ctaE	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
TLS2_k127_3865457_0	1229780.BN381_450053	1.243e-279	875.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,3UWD2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274,ko:K15408	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1,Cyt_c_ox_IV
TLS2_k127_3865457_12	1229780.BN381_450054	1.025e-100	340.0	COG1622@1|root,COG1622@2|Bacteria,2GNXA@201174|Actinobacteria,3UWMS@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	ctaC	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
TLS2_k127_3865457_33	1229780.BN381_450055	3.898e-26	124.0	2FBCP@1|root,343IH@2|Bacteria,2H8EE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3865457_34	1229780.BN381_450056	1.385e-23	117.0	COG1845@1|root,COG1845@2|Bacteria,2HDD0@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
TLS2_k127_3865457_27	1313172.YM304_38710	3.182e-56	218.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4CMUD@84992|Acidimicrobiia	2|Bacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.10.3.10	ko:K02298	ko00190,ko01100,map00190,map01100	M00417	R11335	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.5	-	-	COX1
TLS2_k127_3865457_6	1313172.YM304_38720	9.814e-115	379.0	COG0109@1|root,COG0109@2|Bacteria,2GJMY@201174|Actinobacteria,4CMQ7@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
TLS2_k127_3865457_30	656024.FsymDg_1709	6.497e-48	185.0	COG1612@1|root,COG1612@2|Bacteria,2GJQX@201174|Actinobacteria,4ESN0@85013|Frankiales	201174|Actinobacteria	O	cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
TLS2_k127_3865457_31	1313172.YM304_38150	2.42e-32	139.0	COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria,4CN8E@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ATP-dependent Clp protease adaptor protein ClpS	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
TLS2_k127_3865457_41	1298863.AUEP01000017_gene4146	2.011e-09	66.0	2E4AX@1|root,32Z6K@2|Bacteria,2GW4T@201174|Actinobacteria,4DQGY@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF2017)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2017
TLS2_k127_3865457_37	1122609.AUGT01000029_gene2619	1.341e-18	94.0	COG2856@1|root,COG2856@2|Bacteria,2GPBB@201174|Actinobacteria,4DTVM@85009|Propionibacteriales	201174|Actinobacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3870656_19	316274.Haur_1682	1.008e-61	226.0	COG5267@1|root,COG5267@2|Bacteria,2G7Q0@200795|Chloroflexi,376N0@32061|Chloroflexia	2|Bacteria	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
TLS2_k127_3870656_20	926566.Terro_2358	1.677e-60	233.0	COG4102@1|root,COG4102@2|Bacteria,3Y2YD@57723|Acidobacteria,2JI17@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TLS2_k127_3870656_34	1384056.N787_06545	8.135e-30	138.0	2D125@1|root,32T9R@2|Bacteria,1N30F@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3870656_13	1454004.AW11_01835	1.2e-68	246.0	COG2333@1|root,COG2333@2|Bacteria,1RE10@1224|Proteobacteria,2VX35@28216|Betaproteobacteria	28216|Betaproteobacteria	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3870656_17	258533.BN977_03703	1.146e-65	241.0	COG1752@1|root,COG1752@2|Bacteria,2I9XW@201174|Actinobacteria,236GN@1762|Mycobacteriaceae	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS2_k127_3870656_12	1121033.AUCF01000015_gene1462	1.179e-79	274.0	COG1011@1|root,COG1011@2|Bacteria,1MX48@1224|Proteobacteria,2TUWQ@28211|Alphaproteobacteria,2JRW8@204441|Rhodospirillales	204441|Rhodospirillales	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
TLS2_k127_3870656_26	1229780.BN381_110080	6.903e-52	187.0	COG2329@1|root,COG2329@2|Bacteria,2IM1Q@201174|Actinobacteria,3UXFG@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	1.14.99.57	ko:K21481	-	-	-	-	ko00000,ko01000	-	-	-	ABM
TLS2_k127_3870656_32	1229780.BN381_10335	7.985e-34	137.0	291CY@1|root,2ZNZT@2|Bacteria,2HDEE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3870656_30	675635.Psed_3487	8.225e-38	148.0	COG0071@1|root,COG0071@2|Bacteria,2IPNT@201174|Actinobacteria,4E55C@85010|Pseudonocardiales	201174|Actinobacteria	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS2_k127_3870656_1	1313172.YM304_18480	4.355e-289	897.0	COG1274@1|root,COG1274@2|Bacteria,2GJH3@201174|Actinobacteria,4CMPT@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
TLS2_k127_3870656_39	1313172.YM304_18490	7.733e-24	106.0	COG1278@1|root,COG1278@2|Bacteria,2HC2C@201174|Actinobacteria	201174|Actinobacteria	K	Cold shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	-
TLS2_k127_3870656_37	1229780.BN381_10342	3.343e-26	111.0	COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria,3UX04@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Ribosomal L28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
TLS2_k127_3870656_4	1313172.YM304_18510	2.066e-169	548.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4CMTA@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Dak1_2	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
TLS2_k127_3870656_2	1313172.YM304_18530	9.302e-266	845.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4CMPC@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
TLS2_k127_3870656_6	269800.Tfu_2794	9.295e-124	413.0	COG2132@1|root,COG4454@1|root,COG2132@2|Bacteria,COG4454@2|Bacteria,2GPUP@201174|Actinobacteria,4EFHA@85012|Streptosporangiales	201174|Actinobacteria	PQ	Multicopper oxidase	aniA	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
TLS2_k127_3870656_27	1229780.BN381_170012	2.122e-49	188.0	COG2846@1|root,COG2846@2|Bacteria,2IKUD@201174|Actinobacteria	201174|Actinobacteria	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
TLS2_k127_3870656_15	1229780.BN381_70129	6.457e-66	237.0	COG2345@1|root,COG2345@2|Bacteria,2GQ3A@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_3870656_28	1229780.BN381_330012	2.268e-47	180.0	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,3UWU4@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Conserved hypothetical protein 95	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
TLS2_k127_3870656_14	1229780.BN381_330013	5.128e-68	234.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,3UWQ3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0022607,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034214,GO:0034641,GO:0034654,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0055086,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_3870656_31	1313172.YM304_18600	1.348e-37	163.0	COG0711@1|root,COG0711@2|Bacteria,2HG9T@201174|Actinobacteria,4CN89@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3870656_36	561175.KB894094_gene1869	6.93e-28	120.0	COG1399@1|root,COG1399@2|Bacteria,2GJTS@201174|Actinobacteria,4EJ56@85012|Streptosporangiales	201174|Actinobacteria	S	Uncharacterized ACR, COG1399	-	GO:0008150,GO:0040007	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
TLS2_k127_3870656_40	1313172.YM304_18640	1.612e-19	96.0	COG0333@1|root,COG0333@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
TLS2_k127_3870656_8	1313172.YM304_18650	4.163e-112	370.0	COG0416@1|root,COG0416@2|Bacteria,2I8WT@201174|Actinobacteria,4CMRM@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
TLS2_k127_3870656_29	1313172.YM304_18660	1.199e-43	161.0	COG0236@1|root,COG0236@2|Bacteria,2HG9V@201174|Actinobacteria,4CN8D@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS2_k127_3870656_21	1906.SFRA_24570	1.057e-59	214.0	COG0571@1|root,COG0571@2|Bacteria,2GKER@201174|Actinobacteria	201174|Actinobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
TLS2_k127_3870656_23	1229780.BN381_330022	6.619e-56	206.0	COG0266@1|root,COG0266@2|Bacteria,2GJNT@201174|Actinobacteria	2|Bacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_3870656_0	1313172.YM304_18690	0.0	1177.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4CMQE@84992|Acidimicrobiia	84992|Acidimicrobiia	D	RecF/RecN/SMC N terminal domain	-	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
TLS2_k127_3870656_25	1260251.SPISAL_06925	3.379e-52	202.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the peptidase S1C family	degS	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564	-	ko:K04691,ko:K04772	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_3870656_7	1313172.YM304_18700	3.867e-122	402.0	COG0552@1|root,COG0552@2|Bacteria,2GJQH@201174|Actinobacteria,4CMY6@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54
TLS2_k127_3870656_3	1313172.YM304_18720	3.298e-196	622.0	COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria,4CMPN@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TLS2_k127_3870656_35	1229780.BN381_330035	1.63e-28	127.0	COG0228@1|root,COG0228@2|Bacteria,2IKU0@201174|Actinobacteria,3UWU1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TLS2_k127_3870656_42	1313172.YM304_18740	8.612e-17	89.0	COG1837@1|root,COG1837@2|Bacteria	2|Bacteria	L	Belongs to the UPF0109 family	CP_0960	GO:0008150,GO:0040007	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
TLS2_k127_3870656_38	1236902.ANAS01000008_gene2346	2.7e-24	109.0	COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,4EJ2M@85012|Streptosporangiales	201174|Actinobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0008150,GO:0040007	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
TLS2_k127_3870656_9	1229780.BN381_330038	9.68e-112	367.0	COG0336@1|root,COG0336@2|Bacteria,2GJ1G@201174|Actinobacteria,3UWGW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,tRNA_m1G_MT
TLS2_k127_3870656_24	1121877.JQKF01000047_gene1181	1.034e-52	188.0	COG0335@1|root,COG0335@2|Bacteria,2IHRT@201174|Actinobacteria,4CN2N@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
TLS2_k127_3870656_33	1380356.JNIK01000016_gene3837	7.552e-31	126.0	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4ETCV@85013|Frankiales	201174|Actinobacteria	L	Belongs to the UPF0102 family	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
TLS2_k127_3870656_18	1313172.YM304_24670	1.66e-64	233.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	gpm	-	3.1.3.73,5.4.2.12	ko:K02226,ko:K15634	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00122	R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TLS2_k127_3870656_41	1229780.BN381_330044	2.41e-17	83.0	2E3EP@1|root,31HCP@2|Bacteria,2HM0W@201174|Actinobacteria,3UX08@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3870656_43	717605.Theco_2847	6.71e-07	59.0	COG2010@1|root,COG2010@2|Bacteria,1VEEP@1239|Firmicutes,4HP6N@91061|Bacilli,26ZR6@186822|Paenibacillaceae	91061|Bacilli	C	Cytochrome C oxidase, cbb3-type, subunit III	cccB	-	-	ko:K12263	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3
TLS2_k127_3870656_5	1313172.YM304_27540	2.303e-147	482.0	COG0606@1|root,COG0606@2|Bacteria,2GJIQ@201174|Actinobacteria	201174|Actinobacteria	O	PFAM magnesium chelatase ChlI subunit	comM	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
TLS2_k127_3870656_22	1313172.YM304_27530	1.513e-58	228.0	COG0758@1|root,COG0758@2|Bacteria,2GKDA@201174|Actinobacteria	201174|Actinobacteria	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
TLS2_k127_3870656_10	1313172.YM304_27520	2.03e-91	310.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CN5T@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_3870656_11	1121877.JQKF01000004_gene1136	1.388e-89	328.0	COG1191@1|root,COG1191@2|Bacteria,2GKBK@201174|Actinobacteria,4CMYZ@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sigma-70 region 3	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_3876560_4	1313172.YM304_11260	1.107e-19	95.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r4_2
TLS2_k127_3876560_3	1313172.YM304_28930	2.242e-50	186.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	ydjA	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_3876560_0	67352.JODS01000060_gene7677	2.011e-123	417.0	COG0579@1|root,COG0579@2|Bacteria,2GKFB@201174|Actinobacteria	201174|Actinobacteria	S	FAD dependent oxidoreductase	lhgO	-	-	ko:K15736	-	-	-	-	ko00000,ko01000	-	-	-	DAO
TLS2_k127_3876560_2	1305737.JAFX01000001_gene1520	8.226e-101	331.0	COG0450@1|root,COG0450@2|Bacteria,4NEZZ@976|Bacteroidetes,47KEE@768503|Cytophagia	976|Bacteroidetes	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
TLS2_k127_3876560_1	1121272.KB903249_gene2033	2.466e-108	354.0	COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria,4DBIN@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter ATPase permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
TLS2_k127_3893367_16	675635.Psed_5491	2.101e-23	109.0	COG2453@1|root,COG2453@2|Bacteria,2IHXA@201174|Actinobacteria,4E5XY@85010|Pseudonocardiales	201174|Actinobacteria	T	phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Y_phosphatase
TLS2_k127_3893367_17	1411685.U062_00625	1.563e-21	99.0	COG2329@1|root,COG2329@2|Bacteria	2|Bacteria	S	heme oxygenase (decyclizing) activity	yqjZ	-	2.3.1.128,2.5.1.18	ko:K00799,ko:K03790	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000,ko03009	1.A.12.2.2,1.A.12.3.2	-	-	ABM
TLS2_k127_3893367_2	1033802.SSPSH_003593	8.628e-164	522.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,1RPTM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	methionine synthase	yxjG	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
TLS2_k127_3893367_9	640512.BC1003_5360	2.595e-104	353.0	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2VIDM@28216|Betaproteobacteria,1K42J@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	3.1.1.57	ko:K10221	ko00362,ko00627,ko01120,map00362,map00627,map01120	-	R04277	RC03110	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
TLS2_k127_3893367_6	935261.JAGL01000010_gene1937	3.601e-132	431.0	COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2TQMC@28211|Alphaproteobacteria,43GV4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	PrpF protein	fldA	-	5.3.2.8	ko:K16514	ko00362,ko01120,map00362,map01120	-	R07839	RC02426	ko00000,ko00001,ko01000	-	-	-	PrpF
TLS2_k127_3893367_13	882083.SacmaDRAFT_2716	4.764e-71	253.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria,4E9TU@85010|Pseudonocardiales	201174|Actinobacteria	P	NMT1-like family	ssuA_3	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TLS2_k127_3893367_11	882083.SacmaDRAFT_2713	4.026e-89	316.0	COG1116@1|root,COG1116@2|Bacteria,2GM73@201174|Actinobacteria,4E9GC@85010|Pseudonocardiales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TLS2_k127_3893367_12	500153.JOEK01000021_gene23	9.991e-74	262.0	COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_3893367_15	882083.SacmaDRAFT_2715	5.491e-59	227.0	COG0600@1|root,COG0600@2|Bacteria,2GP2J@201174|Actinobacteria,4EA33@85010|Pseudonocardiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_3893367_8	219305.MCAG_00704	4.511e-125	427.0	COG4638@1|root,COG4638@2|Bacteria,2GKMV@201174|Actinobacteria,4D94V@85008|Micromonosporales	201174|Actinobacteria	P	Rieske [2Fe-2S] domain	-	-	-	ko:K19982	ko00404,ko01130,map00404,map01130	M00790	R11107	RC01333	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
TLS2_k127_3893367_14	43759.JNWK01000001_gene5703	6.986e-63	226.0	COG2030@1|root,COG2030@2|Bacteria,2GIXP@201174|Actinobacteria	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS2_k127_3893367_0	996637.SGM_2540	1.881e-182	591.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_3893367_4	1463909.KL585957_gene2982	8.534e-149	492.0	COG2159@1|root,COG2159@2|Bacteria,2GMQY@201174|Actinobacteria	201174|Actinobacteria	S	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_3893367_5	1133850.SHJG_8617	3.148e-138	447.0	COG1028@1|root,COG1028@2|Bacteria,2GN6U@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
TLS2_k127_3893367_10	591159.ACEZ01000200_gene2465	8.918e-93	314.0	COG3327@1|root,COG3327@2|Bacteria,2GNME@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K02616	-	-	-	-	ko00000,ko03000	-	-	-	PaaX,PaaX_C
TLS2_k127_3893367_18	649638.Trad_2819	1.94e-05	56.0	COG4113@1|root,COG4113@2|Bacteria,1WKRQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_3893367_3	1313172.YM304_41060	3.023e-152	510.0	COG0395@1|root,COG0395@2|Bacteria,2GJNJ@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_3893367_7	1313172.YM304_41070	1.692e-129	428.0	COG1175@1|root,COG1175@2|Bacteria,2GKBJ@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_3893367_1	1313172.YM304_41080	1.372e-168	544.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
TLS2_k127_3990952_0	1229780.BN381_80336	0.0	1207.0	COG0209@1|root,COG0209@2|Bacteria,2GKX9@201174|Actinobacteria,3UWDH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
TLS2_k127_3990952_4	1033730.CAHG01000014_gene1783	1.591e-78	272.0	COG1215@1|root,COG1215@2|Bacteria,2GJTE@201174|Actinobacteria,4DNZE@85009|Propionibacteriales	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_3990952_2	1033730.CAHG01000014_gene1782	2.632e-90	318.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_3990952_7	221360.RS9917_12460	1.304e-16	93.0	COG2327@1|root,COG2327@2|Bacteria,1G05I@1117|Cyanobacteria,1GYV1@1129|Synechococcus	1117|Cyanobacteria	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
TLS2_k127_3990952_3	1033730.CAHG01000014_gene1780	3.246e-90	330.0	COG2244@1|root,COG5305@1|root,COG2244@2|Bacteria,COG5305@2|Bacteria,2GN7C@201174|Actinobacteria,4DW51@85009|Propionibacteriales	201174|Actinobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
TLS2_k127_3990952_6	1033730.CAHG01000014_gene1780	3.078e-50	190.0	COG2244@1|root,COG5305@1|root,COG2244@2|Bacteria,COG5305@2|Bacteria,2GN7C@201174|Actinobacteria,4DW51@85009|Propionibacteriales	201174|Actinobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
TLS2_k127_3990952_1	1033730.CAHG01000014_gene1779	7.521e-163	553.0	COG1215@1|root,COG1215@2|Bacteria,2GKFI@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Cellulose_synt,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
TLS2_k127_3990952_5	526225.Gobs_0227	9.053e-70	267.0	COG3405@1|root,COG3405@2|Bacteria,2GVZR@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolases family 8	-	-	3.2.1.4	ko:K20542	-	-	-	-	ko00000,ko01000	-	GH8	-	Glyco_hydro_8
TLS2_k127_3990952_8	1097668.BYI23_C005360	4.025e-11	69.0	COG0730@1|root,COG0730@2|Bacteria,1R7YW@1224|Proteobacteria,2VQME@28216|Betaproteobacteria,1K4RU@119060|Burkholderiaceae	28216|Betaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_4017150_1	644283.Micau_0342	1.788e-84	297.0	COG1672@1|root,COG1672@2|Bacteria,2GMAZ@201174|Actinobacteria,4DB60@85008|Micromonosporales	201174|Actinobacteria	S	PFAM Archaeal ATPase	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	ATPase_2,DUF234,HTH_5
TLS2_k127_4017150_3	1229780.BN381_130143	1.6e-06	53.0	2DREZ@1|root,33BFB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4017150_2	443218.AS9A_2344	1.915e-80	274.0	COG4912@1|root,COG4912@2|Bacteria,2ID3C@201174|Actinobacteria	201174|Actinobacteria	L	DNA alkylation repair	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
TLS2_k127_4017150_0	1120950.KB892742_gene3002	6.593e-175	567.0	COG3250@1|root,COG3250@2|Bacteria,2GMAT@201174|Actinobacteria,4DPD7@85009|Propionibacteriales	201174|Actinobacteria	G	Beta galactosidase small chain	lacZ	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TLS2_k127_409385_0	1313172.YM304_21700	2.92e-224	711.0	COG0747@1|root,COG0747@2|Bacteria,2GJ9N@201174|Actinobacteria	201174|Actinobacteria	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_409385_3	1229780.BN381_80403	7.005e-109	367.0	COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria,3UWH0@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TLS2_k127_409385_1	1229780.BN381_80402	8.116e-177	560.0	COG0126@1|root,COG0126@2|Bacteria,2GJC6@201174|Actinobacteria,3UWA2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Phosphoglycerate kinase	pgk	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
TLS2_k127_409385_2	1229780.BN381_80401	1.161e-161	516.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,3UW79@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TLS2_k127_409385_4	365528.KB891219_gene1045	4.949e-93	312.0	COG1660@1|root,COG1660@2|Bacteria,2GMWB@201174|Actinobacteria,4EREI@85013|Frankiales	201174|Actinobacteria	S	Displays ATPase and GTPase activities	yvcJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
TLS2_k127_4138075_20	1121946.AUAX01000015_gene6018	1.887e-09	62.0	COG0572@1|root,COG0572@2|Bacteria,2GMCP@201174|Actinobacteria,4D8TG@85008|Micromonosporales	201174|Actinobacteria	F	uridine kinase	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	Cytidylate_kin2,PRK
TLS2_k127_4138075_16	1172180.KB911786_gene47	6.018e-29	127.0	COG2334@1|root,COG2334@2|Bacteria,2GQ6F@201174|Actinobacteria	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_4138075_5	365528.KB891216_gene2575	4.629e-126	411.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_4138075_4	1089546.AQUI01000002_gene585	2.217e-135	451.0	COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria,407ZE@622450|Actinopolysporales	201174|Actinobacteria	P	Sodium:sulfate symporter transmembrane region	sdcS	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
TLS2_k127_4138075_2	1313172.YM304_07770	3.002e-147	476.0	COG1283@1|root,COG1283@2|Bacteria,2IAMX@201174|Actinobacteria	201174|Actinobacteria	P	Na+/Pi-cotransporter	nptA	-	-	ko:K03324,ko:K14683	-	-	-	-	ko00000,ko02000,ko04147	2.A.58.1,2.A.58.2	-	-	Na_Pi_cotrans
TLS2_k127_4138075_13	1313172.YM304_07760	7.48e-58	216.0	COG0704@1|root,COG0704@2|Bacteria,2H63V@201174|Actinobacteria	201174|Actinobacteria	P	PhoU domain	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
TLS2_k127_4138075_19	520709.F985_03842	3.77e-12	70.0	28VEE@1|root,2ZHGZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4138075_18	62928.azo2381	3.564e-12	79.0	COG5305@1|root,COG5305@2|Bacteria,1NAW4@1224|Proteobacteria,2W36X@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4138075_0	1123368.AUIS01000026_gene1471	2.74e-229	719.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,2NCBF@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
TLS2_k127_4138075_15	1229780.BN381_80347	1.032e-34	137.0	2EG9A@1|root,33A12@2|Bacteria,2GQ7U@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4138075_7	1313172.YM304_09420	1.137e-86	305.0	COG1321@1|root,COG1321@2|Bacteria,2GKMC@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	ideR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
TLS2_k127_4138075_1	35754.JNYJ01000046_gene3102	5.544e-172	554.0	COG1520@1|root,COG1520@2|Bacteria,2I9S4@201174|Actinobacteria,4D97G@85008|Micromonosporales	201174|Actinobacteria	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TLS2_k127_4138075_6	1229780.BN381_100200	3.26e-96	326.0	COG3752@1|root,COG3752@2|Bacteria,2GNX1@201174|Actinobacteria,3UXBY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
TLS2_k127_4138075_14	67352.JODS01000013_gene5001	3.229e-44	176.0	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
TLS2_k127_4138075_9	1089544.KB912942_gene7249	2.532e-80	278.0	COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria,4DX3X@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_4138075_12	469383.Cwoe_0731	1.364e-58	222.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria	201174|Actinobacteria	CP	ABC-type Na efflux pump, permease	yhaP	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_4138075_3	1313172.YM304_41190	1.46e-139	460.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_4138075_8	1229780.BN381_100201	1.629e-81	282.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,3UWIT@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS2_k127_4138075_11	28042.GU90_02170	2.499e-64	230.0	COG2050@1|root,COG2050@2|Bacteria,2HT7R@201174|Actinobacteria,4E8JI@85010|Pseudonocardiales	201174|Actinobacteria	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
TLS2_k127_4138075_10	446466.Cfla_1418	2.727e-79	278.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	ubiE11	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
TLS2_k127_4170679_11	743722.Sph21_5022	2.339e-51	187.0	COG2110@1|root,COG2110@2|Bacteria,4NNRH@976|Bacteroidetes,1IS3E@117747|Sphingobacteriia	976|Bacteroidetes	S	COGs COG2110 phosphatase homologous to the C-terminal domain of histone macroH2A1	-	-	-	-	-	-	-	-	-	-	-	-	Macro
TLS2_k127_4170679_15	1122917.KB899662_gene2166	2.589e-09	62.0	COG1403@1|root,COG1403@2|Bacteria,1V4V2@1239|Firmicutes,4HI4X@91061|Bacilli,26VF7@186822|Paenibacillaceae	91061|Bacilli	L	endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
TLS2_k127_4170679_7	153948.NAL212_0224	9.979e-76	268.0	COG1672@1|root,COG1672@2|Bacteria,1MWQD@1224|Proteobacteria,2VK8E@28216|Betaproteobacteria,373VA@32003|Nitrosomonadales	28216|Betaproteobacteria	S	SMART ATPase, AAA type, core	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
TLS2_k127_4170679_8	1157637.KB892091_gene5785	1.93e-70	267.0	COG1846@1|root,COG1846@2|Bacteria,2GMDI@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4170679_0	33876.JNXY01000031_gene3108	1.356e-294	937.0	COG1251@1|root,COG1251@2|Bacteria,2GJ3U@201174|Actinobacteria,4DAVU@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nirB	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
TLS2_k127_4170679_13	1033730.CAHG01000004_gene33	3.887e-24	119.0	COG2146@1|root,COG2146@2|Bacteria,2IQM4@201174|Actinobacteria,4DS3Y@85009|Propionibacteriales	201174|Actinobacteria	P	Nitrite reductase NAD(P)H , small subunit	nirD	-	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske_2
TLS2_k127_4170679_5	402881.Plav_2623	7.308e-92	310.0	COG2267@1|root,COG2267@2|Bacteria,1PFMC@1224|Proteobacteria,2UG1M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_4170679_6	106370.Francci3_0793	6.396e-83	289.0	COG0745@1|root,COG1587@1|root,COG0745@2|Bacteria,COG1587@2|Bacteria,2GKMM@201174|Actinobacteria,4ESGJ@85013|Frankiales	201174|Actinobacteria	HKT	Uroporphyrinogen III synthase HEM4	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,Trans_reg_C
TLS2_k127_4170679_2	1117647.M5M_06255	4.773e-150	492.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RP5H@1236|Gammaproteobacteria,1J8E0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG2223 Nitrate nitrite transporter	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
TLS2_k127_4170679_1	66429.JOFL01000022_gene5754	5.584e-186	606.0	COG0243@1|root,COG0243@2|Bacteria,2GJCK@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K00372,ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530,M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TLS2_k127_4170679_4	471852.Tcur_1362	9.33e-107	355.0	COG2207@1|root,COG2207@2|Bacteria,2GK7Q@201174|Actinobacteria,4EGPW@85012|Streptosporangiales	201174|Actinobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
TLS2_k127_4170679_12	1313172.YM304_16750	3.528e-32	139.0	COG3467@1|root,COG3467@2|Bacteria,2IK9H@201174|Actinobacteria	201174|Actinobacteria	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_4170679_10	243230.DR_0605	1.762e-51	189.0	COG2199@1|root,COG2199@2|Bacteria,1WMNP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	TIGRFAM diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,RHH_3
TLS2_k127_4170679_9	96561.Dole_2248	8.349e-70	248.0	COG1024@1|root,COG1024@2|Bacteria,1MVPQ@1224|Proteobacteria,42ZK8@68525|delta/epsilon subdivisions,2WUST@28221|Deltaproteobacteria,2MNI2@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Enoyl-CoA hydratase isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_4170679_14	44060.JODL01000012_gene3617	2.17e-22	111.0	COG3206@1|root,COG3206@2|Bacteria,2GPMH@201174|Actinobacteria	201174|Actinobacteria	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
TLS2_k127_4170679_3	1229780.BN381_300008	2.147e-125	406.0	COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_4197351_4	1229780.BN381_150140	2.511e-107	366.0	COG0477@1|root,COG0477@2|Bacteria,2I607@201174|Actinobacteria	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_1,MFS_3
TLS2_k127_4197351_16	526225.Gobs_0609	3.256e-50	189.0	COG0125@1|root,COG0125@2|Bacteria,2GNTI@201174|Actinobacteria,4ES48@85013|Frankiales	201174|Actinobacteria	EFGP	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_3,Thymidylate_kin
TLS2_k127_4197351_12	1313172.YM304_03460	1.068e-73	269.0	COG0470@1|root,COG0470@2|Bacteria	2|Bacteria	L	replication factor c	holB	-	2.7.7.7	ko:K02341,ko:K02343,ko:K09384	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
TLS2_k127_4197351_19	479435.Kfla_4172	3.616e-33	148.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2GMKG@201174|Actinobacteria,4DPE5@85009|Propionibacteriales	201174|Actinobacteria	P	CopC domain	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
TLS2_k127_4197351_9	1313172.YM304_37650	9.454e-82	277.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4CMZF@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sigma-70, region 4	sigR	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4197351_21	525909.Afer_1917	1.909e-13	80.0	29XP9@1|root,30JEV@2|Bacteria,2HGER@201174|Actinobacteria,4CNCS@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_4197351_3	1229780.BN381_110020	1.417e-121	402.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,3UXC9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Pfam:Zinicin_2	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
TLS2_k127_4197351_10	1313172.YM304_37680	1.53e-75	266.0	COG0037@1|root,COG0037@2|Bacteria,2GJR4@201174|Actinobacteria,4CN76@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
TLS2_k127_4197351_13	525909.Afer_1913	1.241e-71	246.0	COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,4CNRA@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Phosphoribosyl transferase domain	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS2_k127_4197351_0	351607.Acel_0204	4.329e-229	727.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4ERQQ@85013|Frankiales	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TLS2_k127_4197351_18	666685.R2APBS1_0558	9.468e-36	154.0	COG0546@1|root,COG0546@2|Bacteria,1REXF@1224|Proteobacteria,1S5AR@1236|Gammaproteobacteria,1X67T@135614|Xanthomonadales	135614|Xanthomonadales	S	hydrolase	idgB	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_4197351_11	1229780.BN381_110025	4.837e-75	264.0	COG0294@1|root,COG0294@2|Bacteria,2GJDQ@201174|Actinobacteria,3UWGD@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK,Pterin_bind
TLS2_k127_4197351_14	1229780.BN381_110026	7.22e-63	220.0	2F3QB@1|root,33WH4@2|Bacteria,2H50W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4197351_20	1229780.BN381_110027	3.108e-29	123.0	COG1539@1|root,COG1539@2|Bacteria,2IHSW@201174|Actinobacteria,3UWX7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	GO:0008150,GO:0040007	1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8	ko:K01633,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00840	R03503,R03504,R11037,R11073	RC00002,RC00017,RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
TLS2_k127_4197351_17	1229780.BN381_110028	9.321e-42	164.0	COG0801@1|root,COG0801@2|Bacteria,2H3G6@201174|Actinobacteria,3UWU2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
TLS2_k127_4197351_15	1229780.BN381_110029	3.514e-51	195.0	COG5495@1|root,COG5495@2|Bacteria,2HGVN@201174|Actinobacteria,3UXIN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Domain of unknown function (DUF2520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520
TLS2_k127_4197351_8	1229780.BN381_110030	2.602e-84	302.0	COG0414@1|root,COG0414@2|Bacteria,2GJEQ@201174|Actinobacteria,3UWKZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
TLS2_k127_4197351_1	1229780.BN381_110031	8.636e-181	584.0	COG0029@1|root,COG0029@2|Bacteria,2I2IJ@201174|Actinobacteria,3UW8F@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Fumarate reductase flavoprotein C-term	nadB	GO:0008150,GO:0040007	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1595	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_4197351_6	1313172.YM304_37700	1.446e-89	326.0	COG4894@1|root,COG4894@2|Bacteria,2GMU8@201174|Actinobacteria	201174|Actinobacteria	S	Scramblase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,Scramblase
TLS2_k127_4197351_5	1229780.BN381_110032	4.566e-90	306.0	COG0157@1|root,COG0157@2|Bacteria,2GV9P@201174|Actinobacteria,3UWIJ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Quinolinate phosphoribosyl transferase, N-terminal domain	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
TLS2_k127_4197351_7	1229780.BN381_110048	9.257e-89	304.0	COG1521@1|root,COG1521@2|Bacteria,2GMRQ@201174|Actinobacteria,3UWI1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
TLS2_k127_4197351_2	469383.Cwoe_2515	2.391e-151	510.0	COG1190@1|root,COG2898@1|root,COG1190@2|Bacteria,COG2898@2|Bacteria,2GKE0@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	-	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DUF2156,tRNA-synt_2,tRNA_anti-codon
TLS2_k127_4197351_23	1313172.YM304_01190	0.0007031	47.0	29A8B@1|root,2ZX98@2|Bacteria,2H1CP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4217653_8	1146883.BLASA_2205	3.587e-31	132.0	2DE70@1|root,2ZKSR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4217653_7	1304865.JAGF01000001_gene46	1.504e-66	231.0	COG0748@1|root,COG0748@2|Bacteria,2IP6Y@201174|Actinobacteria	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS2_k127_4217653_3	369723.Strop_2972	1.396e-142	460.0	COG1052@1|root,COG1052@2|Bacteria,2GN32@201174|Actinobacteria,4DDKI@85008|Micromonosporales	201174|Actinobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	pdxB	-	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_4217653_2	1043493.BBLU01000017_gene1369	1.875e-147	482.0	COG1620@1|root,COG1620@2|Bacteria,2GIUF@201174|Actinobacteria	201174|Actinobacteria	C	L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
TLS2_k127_4217653_5	1108045.GORHZ_134_00040	8.356e-98	328.0	2DM5A@1|root,31SBV@2|Bacteria,2IPT3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4217653_6	1449976.KALB_6512	1.867e-83	291.0	COG0572@1|root,COG0572@2|Bacteria,2GMCP@201174|Actinobacteria,4E35R@85010|Pseudonocardiales	201174|Actinobacteria	F	uridine kinase	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
TLS2_k127_4217653_10	675635.Psed_5849	1.155e-13	80.0	COG0644@1|root,COG0644@2|Bacteria,2HZIE@201174|Actinobacteria,4EBY4@85010|Pseudonocardiales	201174|Actinobacteria	C	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4217653_1	1112204.GPOL_c45840	4.849e-158	511.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4GBFR@85026|Gordoniaceae	201174|Actinobacteria	U	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4217653_0	1380390.JIAT01000014_gene6208	3.835e-237	751.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,NB-ARC,Response_reg,TIR_2,TPR_10,TPR_12
TLS2_k127_4217653_4	1380390.JIAT01000014_gene6209	6.737e-105	348.0	COG0596@1|root,COG0596@2|Bacteria,2IKJJ@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_4217653_9	1240349.ANGC01000013_gene468	6.958e-14	71.0	COG0209@1|root,COG0209@2|Bacteria,2GKX9@201174|Actinobacteria,4FWF5@85025|Nocardiaceae	201174|Actinobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
TLS2_k127_4293667_7	1397666.RS24_01411	1.098e-05	48.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,4BQ5W@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS2_k127_4293667_5	471854.Dfer_2215	1.394e-09	71.0	28NR7@1|root,2ZBQI@2|Bacteria,4NMCH@976|Bacteroidetes,47WBS@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4293667_4	1385520.N802_10410	4.305e-21	94.0	COG3360@1|root,COG3360@2|Bacteria,2ISR4@201174|Actinobacteria	201174|Actinobacteria	S	Dodecin	secE2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
TLS2_k127_4293667_6	243365.CV_2526	4.553e-06	55.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VRGJ@28216|Betaproteobacteria,2KTAU@206351|Neisseriales	206351|Neisseriales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4293667_0	443218.AS9A_0987	1.86e-167	542.0	COG2267@1|root,COG2267@2|Bacteria,2I9JC@201174|Actinobacteria	201174|Actinobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
TLS2_k127_4293667_1	1123288.SOV_3c05780	1.415e-102	366.0	COG0577@1|root,COG0577@2|Bacteria,1U388@1239|Firmicutes,4H32X@909932|Negativicutes	909932|Negativicutes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_4293667_2	357808.RoseRS_3212	8.552e-79	273.0	COG0664@1|root,COG1136@1|root,COG0664@2|Bacteria,COG1136@2|Bacteria,2G6C9@200795|Chloroflexi,37685@32061|Chloroflexia	32061|Chloroflexia	V	ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,cNMP_binding
TLS2_k127_4293667_3	2074.JNYD01000047_gene7401	8.696e-31	130.0	arCOG10456@1|root,2ZA6T@2|Bacteria,2IT80@201174|Actinobacteria,4E5JH@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4319860_7	1894.JOER01000065_gene4326	2.631e-18	94.0	COG2306@1|root,COG2306@2|Bacteria,2GQIN@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF402)	-	-	-	-	-	-	-	-	-	-	-	-	DUF402
TLS2_k127_4319860_5	561175.KB894096_gene658	3.489e-62	223.0	COG2813@1|root,COG2813@2|Bacteria,2IFG7@201174|Actinobacteria,4EFU8@85012|Streptosporangiales	201174|Actinobacteria	J	Putative methyltransferase	rsmC	-	2.1.1.172	ko:K00564	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS
TLS2_k127_4319860_4	1229780.BN381_50154	1.021e-63	224.0	COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,3UWS7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TLS2_k127_4319860_3	1313172.YM304_20570	2.041e-87	305.0	COG0223@1|root,COG0223@2|Bacteria,2GKH5@201174|Actinobacteria,4CN6M@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Formyl transferase, C-terminal domain	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TLS2_k127_4319860_2	1313172.YM304_20580	3.459e-109	382.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2GM21@201174|Actinobacteria	201174|Actinobacteria	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	fmu	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
TLS2_k127_4319860_6	1313172.YM304_20590	1.873e-53	192.0	COG0521@1|root,COG0521@2|Bacteria,2II28@201174|Actinobacteria,4CN1Q@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
TLS2_k127_4319860_1	1229780.BN381_50158	1.17e-121	401.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2GKAX@201174|Actinobacteria,3UWIW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
TLS2_k127_4319860_0	710111.FraQA3DRAFT_6315	8.491e-161	535.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GIWJ@201174|Actinobacteria,4ERH4@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
TLS2_k127_4363626_10	1229780.BN381_60041	3.735e-51	191.0	COG1587@1|root,COG1587@2|Bacteria,2GMJZ@201174|Actinobacteria,3UWX3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Uroporphyrinogen-III synthase HemD	hemD	-	2.1.1.107,4.2.1.75	ko:K01719,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
TLS2_k127_4363626_11	765420.OSCT_0159	2.768e-49	191.0	COG0637@1|root,COG0637@2|Bacteria,2G6ZZ@200795|Chloroflexi,377EF@32061|Chloroflexia	32061|Chloroflexia	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_4363626_7	1123024.AUII01000033_gene1401	3.04e-79	271.0	COG0596@1|root,COG0596@2|Bacteria,2IAKH@201174|Actinobacteria,4E9MU@85010|Pseudonocardiales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_4363626_3	1229780.BN381_60037	1.596e-139	451.0	COG0113@1|root,COG0113@2|Bacteria,2GJJ0@201174|Actinobacteria,3UW8S@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Delta-aminolevulinic acid dehydratase	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
TLS2_k127_4363626_0	1229780.BN381_60036	1.564e-174	569.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,3UW7J@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Glutamate-1-semialdehyde aminotransferase	hemL	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_4363626_2	710685.MycrhN_5062	3.974e-142	468.0	COG2267@1|root,COG3710@1|root,COG2267@2|Bacteria,COG3710@2|Bacteria,2I419@201174|Actinobacteria,234R8@1762|Mycobacteriaceae	201174|Actinobacteria	IK	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Trans_reg_C
TLS2_k127_4363626_14	1313172.YM304_03980	8.198e-37	149.0	COG2010@1|root,COG2010@2|Bacteria,2H5KX@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4363626_13	1229780.BN381_450013	5.436e-37	144.0	2C3UQ@1|root,341WW@2|Bacteria,2H6NT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4363626_8	1229780.BN381_450012	7.255e-75	252.0	COG1143@1|root,COG1143@2|Bacteria,2H4NQ@201174|Actinobacteria	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10
TLS2_k127_4363626_1	1229780.BN381_450011	1.609e-152	483.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome b	-	-	-	ko:K03887	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_B
TLS2_k127_4363626_4	1229780.BN381_450010	1.843e-97	337.0	COG1290@1|root,COG1290@2|Bacteria,2H1Y8@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome b(C-terminal)/b6/petD	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
TLS2_k127_4363626_5	1229780.BN381_450009	5.682e-86	295.0	COG0723@1|root,COG0723@2|Bacteria,2H0R5@201174|Actinobacteria	201174|Actinobacteria	C	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
TLS2_k127_4363626_9	1313172.YM304_04040	7.3e-75	264.0	COG2010@1|root,COG2010@2|Bacteria,2H49G@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS2_k127_4363626_15	1229780.BN381_450007	7.098e-30	129.0	2FE68@1|root,34663@2|Bacteria,2H83B@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4363626_12	1229780.BN381_450006	2.302e-43	163.0	COG0838@1|root,COG0838@2|Bacteria,2IKWT@201174|Actinobacteria,3UXDH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TLS2_k127_4363626_6	1313172.YM304_04070	1.822e-84	293.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,4CMXA@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TLS2_k127_4393282_12	196490.AUEZ01000053_gene127	2.054e-53	192.0	COG0596@1|root,COG0596@2|Bacteria,1N5ZI@1224|Proteobacteria,2TS7X@28211|Alphaproteobacteria,3JT68@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	ephA	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_4393282_14	67257.JODR01000006_gene2671	1.575e-43	165.0	COG0517@1|root,COG0517@2|Bacteria,2IHPB@201174|Actinobacteria	201174|Actinobacteria	S	Cbs domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_4393282_2	1283299.AUKG01000001_gene3563	2.261e-99	337.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria,4CPQF@84995|Rubrobacteria	84995|Rubrobacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_4393282_13	1203602.HMPREF1527_00582	3.493e-48	182.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4CUM2@84998|Coriobacteriia	84998|Coriobacteriia	K	RNA polymerase sigma-70 factor, sigma-B F G subfamily	-	-	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_4393282_5	797209.ZOD2009_20687	1.437e-85	305.0	COG1501@1|root,arCOG03663@2157|Archaea,2XV49@28890|Euryarchaeota,23V0G@183963|Halobacteria	183963|Halobacteria	G	Melibiase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase
TLS2_k127_4393282_16	1463900.JOIX01000057_gene3163	4.422e-37	143.0	COG0346@1|root,COG0346@2|Bacteria,2II0X@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_4393282_8	103733.JNYO01000004_gene7383	5.184e-59	208.0	COG1764@1|root,COG1764@2|Bacteria,2IFFB@201174|Actinobacteria,4E3HZ@85010|Pseudonocardiales	201174|Actinobacteria	O	PFAM OsmC-like protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
TLS2_k127_4393282_21	1386089.N865_18910	2.342e-15	82.0	2EHZA@1|root,33BQS@2|Bacteria,2IJZ0@201174|Actinobacteria,4FGP6@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4393282_15	1380356.JNIK01000015_gene2721	1.016e-38	154.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,4ES4X@85013|Frankiales	201174|Actinobacteria	J	Ribosomal RNA methyltransferase RrmJ FtsJ	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
TLS2_k127_4393282_1	1463825.JNXC01000034_gene2636	6.651e-160	522.0	COG0380@1|root,COG0380@2|Bacteria,2GMX7@201174|Actinobacteria,4DYIK@85010|Pseudonocardiales	201174|Actinobacteria	G	synthase	otsA	GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
TLS2_k127_4393282_4	1313172.YM304_11680	1.702e-94	319.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_4393282_7	1313172.YM304_13940	1.308e-75	260.0	COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,4CNX1@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Haemolysin-III related	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
TLS2_k127_4393282_20	1907.SGLAU_18840	1.89e-17	94.0	COG3402@1|root,COG3402@2|Bacteria,2IR88@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
TLS2_k127_4393282_19	28444.JODQ01000007_gene5648	5.257e-24	117.0	COG3428@1|root,COG3428@2|Bacteria,2GJCD@201174|Actinobacteria,4EHH6@85012|Streptosporangiales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
TLS2_k127_4393282_18	1229780.BN381_410005	1.133e-29	128.0	COG1141@1|root,COG1141@2|Bacteria,2IKKX@201174|Actinobacteria	201174|Actinobacteria	C	ferredoxin	fdxG	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_15
TLS2_k127_4393282_10	1035308.AQYY01000002_gene33	1.445e-57	224.0	COG1246@1|root,COG1246@2|Bacteria,1VUUV@1239|Firmicutes,25E0G@186801|Clostridia	186801|Clostridia	E	Belongs to the acetyltransferase family. ArgA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Imp-YgjV
TLS2_k127_4393282_11	402881.Plav_3101	4.01e-54	211.0	COG2271@1|root,COG2271@2|Bacteria,1QXWV@1224|Proteobacteria,2TYHZ@28211|Alphaproteobacteria,1JPUB@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4393282_9	316058.RPB_4163	2.442e-58	211.0	COG0412@1|root,COG0412@2|Bacteria,1NRB4@1224|Proteobacteria,2TU91@28211|Alphaproteobacteria,3JUQK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TLS2_k127_4393282_0	1229780.BN381_210110	2.625e-186	594.0	COG1960@1|root,COG1960@2|Bacteria,2HY6H@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE21	-	-	ko:K00257	-	-	R04547,R04592	RC01942	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_4393282_17	1313172.YM304_06330	1.057e-30	125.0	COG0295@1|root,COG0295@2|Bacteria	2|Bacteria	F	cytidine deaminase activity	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
TLS2_k127_4393282_6	1273125.Rrhod_0213	6.298e-78	276.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4FUBU@85025|Nocardiaceae	201174|Actinobacteria	G	Glucose-6-phosphate dehydrogenase, C-terminal domain	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TLS2_k127_4393282_3	1033743.CAES01000011_gene4275	1.1e-95	321.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,4HAWD@91061|Bacilli,26WJN@186822|Paenibacillaceae	91061|Bacilli	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
TLS2_k127_4393282_22	1046724.KB889930_gene1265	3.166e-09	59.0	COG0765@1|root,COG0765@2|Bacteria,1MWF0@1224|Proteobacteria,1SZ5K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	amino acid	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
TLS2_k127_4410725_5	526225.Gobs_1143	1.092e-57	207.0	COG0028@1|root,COG0028@2|Bacteria,2GN3X@201174|Actinobacteria,4EWD4@85013|Frankiales	201174|Actinobacteria	EH	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	ilvX	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0030312,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
TLS2_k127_4410725_6	1179773.BN6_02640	9.821e-43	162.0	COG0783@1|root,COG0783@2|Bacteria,2IFDP@201174|Actinobacteria,4E3P7@85010|Pseudonocardiales	201174|Actinobacteria	P	Belongs to the Dps family	dps	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
TLS2_k127_4410725_8	1312959.KI914666_gene3659	8.777e-30	125.0	COG0735@1|root,COG0735@2|Bacteria,2IFBR@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the Fur family	catR	-	-	ko:K22297	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_4410725_10	1313172.YM304_22490	1.244e-27	118.0	2FJAX@1|root,34B0V@2|Bacteria,2H7B1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4410725_4	929712.KI912613_gene1434	6.506e-59	216.0	COG2267@1|root,COG2267@2|Bacteria,2I79Z@201174|Actinobacteria	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_4410725_3	743718.Isova_1389	2.103e-79	282.0	COG1119@1|root,COG1119@2|Bacteria,2GIXX@201174|Actinobacteria,4F3X4@85017|Promicromonosporaceae	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	ylmA	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
TLS2_k127_4410725_9	1211815.CBYP010000067_gene113	7.101e-29	123.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_4410725_7	1313172.YM304_31100	4.352e-38	160.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21471,ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	LysM,Peptidase_M23
TLS2_k127_4410725_1	1283283.ATXA01000001_gene905	3.815e-108	356.0	COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria,4ERER@85013|Frankiales	201174|Actinobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	inhA	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030312,GO:0030497,GO:0031406,GO:0032787,GO:0033293,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208,ko:K11611	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_4410725_2	1229780.BN381_50168	2.384e-90	304.0	COG2085@1|root,COG2085@2|Bacteria,2GMZ5@201174|Actinobacteria	201174|Actinobacteria	S	PFAM NADP oxidoreductase coenzyme F420-dependent	npdG	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
TLS2_k127_4410725_0	1229780.BN381_50169	4.776e-191	612.0	COG0215@1|root,COG0215@2|Bacteria,2GJZR@201174|Actinobacteria,3UX20@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	tRNA synthetases class I (C) catalytic domain	mshC	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1e
TLS2_k127_4410725_11	1463855.JOHV01000008_gene5339	4.317e-16	79.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria	201174|Actinobacteria	GM	Nad-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
TLS2_k127_4423427_14	1449048.JQKU01000037_gene1759	3.107e-41	156.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,2339N@1762|Mycobacteriaceae	201174|Actinobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Reductase_C
TLS2_k127_4423427_16	318424.EU78_18875	1.515e-15	78.0	COG1141@1|root,COG1141@2|Bacteria,2GT1Y@201174|Actinobacteria,23B8Y@1762|Mycobacteriaceae	201174|Actinobacteria	C	ferredoxin	fdxD_2	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13,Fer4_15
TLS2_k127_4423427_8	1121928.AUHE01000007_gene1222	1.325e-80	281.0	COG1028@1|root,COG1028@2|Bacteria,2GNM4@201174|Actinobacteria,4GD3I@85026|Gordoniaceae	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_4423427_2	644283.Micau_5428	4.221e-138	456.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4D8HC@85008|Micromonosporales	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
TLS2_k127_4423427_4	929712.KI912613_gene4227	1.204e-118	391.0	COG1215@1|root,COG1215@2|Bacteria,2I2PK@201174|Actinobacteria,4CPE1@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_4423427_13	1532558.JL39_07820	1.095e-42	158.0	COG0640@1|root,COG0640@2|Bacteria,1N3ZI@1224|Proteobacteria,2UCYW@28211|Alphaproteobacteria,4BF8X@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_4423427_10	263358.VAB18032_18970	4.117e-73	248.0	COG3832@1|root,COG3832@2|Bacteria,2HX0J@201174|Actinobacteria,4DKWA@85008|Micromonosporales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_4423427_7	1121033.AUCF01000012_gene953	2.144e-90	316.0	COG0154@1|root,COG0154@2|Bacteria,1MU51@1224|Proteobacteria,2TS1E@28211|Alphaproteobacteria,2JQ0T@204441|Rhodospirillales	204441|Rhodospirillales	J	COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS2_k127_4423427_12	1172180.KB911780_gene7276	2.676e-61	234.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria	201174|Actinobacteria	I	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TLS2_k127_4423427_3	1242864.D187_002507	6.629e-123	412.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24,SEC-C
TLS2_k127_4423427_6	269800.Tfu_1961	1.136e-96	326.0	COG0009@1|root,COG0009@2|Bacteria,2GK2X@201174|Actinobacteria,4EIA3@85012|Streptosporangiales	201174|Actinobacteria	J	Belongs to the SUA5 family	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
TLS2_k127_4423427_0	649831.L083_2761	1.628e-221	702.0	COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,4D8XJ@85008|Micromonosporales	201174|Actinobacteria	G	Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
TLS2_k127_4423427_15	756272.Plabr_3042	1.093e-38	150.0	COG3476@1|root,COG3476@2|Bacteria,2J03F@203682|Planctomycetes	203682|Planctomycetes	T	PFAM TspO MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
TLS2_k127_4423427_9	1121877.JQKF01000003_gene1581	5.156e-77	261.0	COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,4CMYS@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
TLS2_k127_4423427_11	1382359.JIAL01000001_gene2776	1.53e-66	234.0	COG3467@1|root,COG3467@2|Bacteria,3Y4HI@57723|Acidobacteria,2JMS6@204432|Acidobacteriia	204432|Acidobacteriia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
TLS2_k127_4423427_1	1229780.BN381_90064	5.182e-142	466.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,3UX2T@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Molybdenum Cofactor Synthesis C	moaA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
TLS2_k127_4423427_5	1313172.YM304_11030	1.703e-111	374.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4CMP8@84992|Acidimicrobiia	84992|Acidimicrobiia	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS2_k127_4446696_1	1229780.BN381_330069	3.121e-165	533.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,3UW9A@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Participates in both transcription termination and antitermination	nusA	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
TLS2_k127_4446696_9	1151118.KB895792_gene1960	4.638e-10	67.0	COG2740@1|root,COG2740@2|Bacteria,2GQH0@201174|Actinobacteria,1WA8F@1268|Micrococcaceae	201174|Actinobacteria	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
TLS2_k127_4446696_0	1313172.YM304_15900	3.854e-295	935.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4CMS2@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
TLS2_k127_4446696_7	1229780.BN381_330071	3.781e-22	98.0	COG1550@1|root,COG1550@2|Bacteria,2I1A0@201174|Actinobacteria,3UXQB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Protein of unknown function (DUF503)	-	-	-	-	-	-	-	-	-	-	-	-	DUF503
TLS2_k127_4446696_8	1313172.YM304_15980	9.55e-21	96.0	COG0858@1|root,COG0858@2|Bacteria,2HGGX@201174|Actinobacteria,4CNEB@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
TLS2_k127_4446696_3	1313172.YM304_15990	6.279e-83	284.0	COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4CN62@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
TLS2_k127_4446696_2	1313172.YM304_16060	9.802e-103	345.0	COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4CN39@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Riboflavin kinase	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
TLS2_k127_4446696_5	1298860.AUEM01000004_gene3043	1.614e-51	193.0	COG0730@1|root,COG0730@2|Bacteria,2I5VT@201174|Actinobacteria,4FNYV@85023|Microbacteriaceae	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_4446696_4	1394178.AWOO02000081_gene2209	1.601e-74	261.0	COG1946@1|root,COG1946@2|Bacteria,2GJ1B@201174|Actinobacteria,4EH1N@85012|Streptosporangiales	201174|Actinobacteria	I	Acyl-CoA thioesterase	-	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
TLS2_k127_4446696_6	1114959.SZMC14600_06485	8.03e-50	191.0	COG1960@1|root,COG1960@2|Bacteria,2HEKC@201174|Actinobacteria,4DZQY@85010|Pseudonocardiales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_4485364_3	485913.Krac_5237	1.415e-19	91.0	COG1011@1|root,COG1011@2|Bacteria,2G787@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	3.1.3.10	ko:K07025,ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_4485364_0	1079986.JH164876_gene2473	8.557e-167	539.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria	201174|Actinobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	-	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1g
TLS2_k127_4485364_4	1096930.L284_21625	8.74e-15	79.0	COG0537@1|root,COG0537@2|Bacteria,1N49J@1224|Proteobacteria,2U85A@28211|Alphaproteobacteria,2K4UB@204457|Sphingomonadales	204457|Sphingomonadales	FG	Histidine triad (HIT) protein	-	-	-	-	-	-	-	-	-	-	-	-	HIT
TLS2_k127_4485364_1	1323361.JPOC01000029_gene2377	4.915e-139	447.0	COG2267@1|root,COG2267@2|Bacteria,2H83P@201174|Actinobacteria,4FWQ7@85025|Nocardiaceae	201174|Actinobacteria	I	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
TLS2_k127_4485364_2	1229780.BN381_80160	2.707e-48	175.0	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,3UWTI@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
TLS2_k127_4526601_10	1313172.YM304_11630	1.262e-43	166.0	COG0079@1|root,COG0079@2|Bacteria	2|Bacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	cobB	GO:0008150,GO:0040007	2.6.1.9,4.1.1.81,6.3.5.11,6.3.5.9	ko:K00817,ko:K02224,ko:K04720	ko00340,ko00350,ko00360,ko00400,ko00401,ko00860,ko00960,ko01100,ko01110,ko01120,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01120,map01130,map01230	M00026	R00694,R00734,R03243,R05224,R05815,R06530	RC00006,RC00010,RC00517,RC00888,RC01301	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2,CbiA,CbiG_C,GATase_3
TLS2_k127_4526601_4	1122622.ATWJ01000002_gene838	2.61e-81	291.0	COG1270@1|root,COG1270@2|Bacteria,2GMB8@201174|Actinobacteria,4FEC6@85021|Intrasporangiaceae	201174|Actinobacteria	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
TLS2_k127_4526601_14	1121033.AUCF01000005_gene5398	4.764e-29	130.0	COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,2U97D@28211|Alphaproteobacteria,2JSSP@204441|Rhodospirillales	204441|Rhodospirillales	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
TLS2_k127_4526601_13	1120934.KB894405_gene5370	1.668e-30	138.0	COG2087@1|root,COG2087@2|Bacteria,2GM8Q@201174|Actinobacteria,4E5NE@85010|Pseudonocardiales	201174|Actinobacteria	H	PFAM Cobinamide kinase cobinamide phosphate guanyltransferase	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU,DBI_PRT
TLS2_k127_4526601_7	644283.Micau_5904	3.697e-65	235.0	COG1865@1|root,COG1865@2|Bacteria,2I8C5@201174|Actinobacteria,4DBX2@85008|Micromonosporales	201174|Actinobacteria	S	Adenosylcobinamide amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CbiZ
TLS2_k127_4526601_5	1229780.BN381_420011	2.701e-77	267.0	COG2109@1|root,COG2109@2|Bacteria,2GNJQ@201174|Actinobacteria,3UXDI@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP	cobO	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
TLS2_k127_4526601_15	1313172.YM304_37140	4.351e-28	130.0	COG2334@1|root,COG2334@2|Bacteria,2H4PV@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1679)	-	-	-	-	-	-	-	-	-	-	-	-	EcKinase
TLS2_k127_4526601_11	710696.Intca_0462	6.774e-35	135.0	2DNXR@1|root,32ZPP@2|Bacteria,2I2KW@201174|Actinobacteria,4FHNT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905
TLS2_k127_4526601_0	1229780.BN381_60013	7.283e-302	949.0	COG0187@1|root,COG0187@2|Bacteria,2GM1E@201174|Actinobacteria,3UWFD@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	TopoisomeraseII	gyrB2	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS2_k127_4526601_1	1229780.BN381_60010	5.578e-291	923.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,3UWFC@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DNA Topoisomerase IV	gyrA2	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS2_k127_4526601_2	1123320.KB889675_gene3977	3.225e-105	357.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria	201174|Actinobacteria	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_4526601_6	1077144.AGFF01000023_gene1383	3.736e-67	239.0	2DMG6@1|root,32RB5@2|Bacteria,2GMQI@201174|Actinobacteria	201174|Actinobacteria	S	MDMPI C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
TLS2_k127_4526601_12	211114.JOEF01000018_gene6182	5.927e-31	132.0	COG5285@1|root,COG5285@2|Bacteria,2HTSH@201174|Actinobacteria,4E5VM@85010|Pseudonocardiales	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS2_k127_4526601_9	216591.BCAS0267a	3.472e-45	174.0	COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,2W0RM@28216|Betaproteobacteria,1K4QW@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
TLS2_k127_4526601_8	1333998.M2A_2548	4.057e-58	210.0	COG1024@1|root,COG1024@2|Bacteria,1RAAV@1224|Proteobacteria,2UB9Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG1024 Enoyl-CoA hydratase carnithine racemase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_4526601_3	1289387.AUKW01000002_gene321	1.011e-89	311.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
TLS2_k127_4546826_16	215358.XP_010744200.1	1.683e-09	65.0	COG0484@1|root,KOG0550@2759|Eukaryota,38CD1@33154|Opisthokonta,3BAMR@33208|Metazoa,3CY9P@33213|Bilateria	33208|Metazoa	O	chaperone cofactor-dependent protein refolding	DNAJC7	GO:0001671,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008047,GO:0008150,GO:0009987,GO:0030234,GO:0031072,GO:0031974,GO:0031981,GO:0032781,GO:0043085,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043462,GO:0044093,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0051082,GO:0051084,GO:0051085,GO:0051336,GO:0051345,GO:0060589,GO:0060590,GO:0061077,GO:0065007,GO:0065009,GO:0070013,GO:0080134,GO:0080135,GO:0098772,GO:1900034	-	ko:K09527	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TPR_1,TPR_16,TPR_2,TPR_8
TLS2_k127_4546826_15	1313172.YM304_21890	3.831e-17	84.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	VY92_08690	-	5.3.1.32	ko:K11530	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	ABM
TLS2_k127_4546826_5	1313172.YM304_24270	9.96e-91	306.0	COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,4CN2P@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Indole-3-glycerol phosphate synthase	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
TLS2_k127_4546826_7	1313172.YM304_24300	3.733e-75	260.0	COG0135@1|root,COG0135@2|Bacteria,2IHPP@201174|Actinobacteria,4CN2A@84992|Acidimicrobiia	84992|Acidimicrobiia	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
TLS2_k127_4546826_0	1229780.BN381_50177	7.58e-199	636.0	COG0133@1|root,COG0133@2|Bacteria,2GM7Z@201174|Actinobacteria,3UWAH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_4546826_4	1229780.BN381_50178	1.819e-92	325.0	COG0159@1|root,COG0159@2|Bacteria,2GN6T@201174|Actinobacteria,3UWK3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
TLS2_k127_4546826_11	1146883.BLASA_1325	5.082e-41	155.0	COG2346@1|root,COG2346@2|Bacteria,2IKPF@201174|Actinobacteria,4ESTB@85013|Frankiales	201174|Actinobacteria	S	PFAM globin	glbO	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
TLS2_k127_4546826_13	1123013.AUIC01000002_gene964	3.083e-28	118.0	COG0776@1|root,COG0776@2|Bacteria,2IKQR@201174|Actinobacteria,4FPGU@85023|Microbacteriaceae	201174|Actinobacteria	L	bacterial (prokaryotic) histone like domain	hup	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_4546826_8	1313172.YM304_17780	3.02e-62	225.0	COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,4CN8N@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS2_k127_4546826_10	1313172.YM304_21280	8.944e-51	194.0	COG0764@1|root,COG0764@2|Bacteria,2GQWT@201174|Actinobacteria,4CN5K@84992|Acidimicrobiia	84992|Acidimicrobiia	I	FabA-like domain	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
TLS2_k127_4546826_12	1283299.AUKG01000001_gene3249	1.411e-29	127.0	COG1595@1|root,COG1595@2|Bacteria,2II47@201174|Actinobacteria,4CSB0@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4546826_9	471853.Bcav_4054	4.117e-53	201.0	COG0350@1|root,COG0350@2|Bacteria,2GKA9@201174|Actinobacteria	201174|Actinobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
TLS2_k127_4546826_2	1313172.YM304_21300	9.794e-140	458.0	COG0304@1|root,COG0304@2|Bacteria,2GIY4@201174|Actinobacteria,4CMVV@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS2_k127_4546826_14	1313172.YM304_21310	1.674e-22	100.0	COG0236@1|root,COG0236@2|Bacteria,2HGA0@201174|Actinobacteria,4CN8U@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS2_k127_4546826_6	1172179.AUKV01000020_gene1487	2.543e-88	312.0	COG1028@1|root,COG1028@2|Bacteria,2GK6C@201174|Actinobacteria	201174|Actinobacteria	IQ	reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_4546826_3	1313172.YM304_21330	3.179e-117	404.0	COG0332@1|root,COG0332@2|Bacteria,2GJP8@201174|Actinobacteria,4CMQV@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
TLS2_k127_4546826_1	1313172.YM304_21340	1.122e-148	481.0	COG0331@1|root,COG0331@2|Bacteria,2GME0@201174|Actinobacteria,4CMPZ@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl transferase domain	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
TLS2_k127_4557037_1	1249627.D779_0619	8.104e-206	664.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1WXMM@135613|Chromatiales	135613|Chromatiales	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
TLS2_k127_4557037_6	1229780.BN381_210088	2.848e-93	317.0	COG0491@1|root,COG0491@2|Bacteria,2GKJA@201174|Actinobacteria,3UXGK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_4557037_12	1229780.BN381_210091	2.661e-33	136.0	COG1848@1|root,COG1848@2|Bacteria,2H8GW@201174|Actinobacteria	201174|Actinobacteria	S	PIN domain	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_4557037_16	1229780.BN381_210092	9.758e-16	81.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS2_k127_4557037_4	1229780.BN381_210093	1.118e-172	548.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,3UXCB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_4557037_7	1313172.YM304_30260	9.536e-76	262.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	ycjY	GO:0008150,GO:0009987,GO:0051301	-	ko:K01990,ko:K06889	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	DLH,Hydrolase_4,Peptidase_S15
TLS2_k127_4557037_11	1313172.YM304_14780	9.927e-37	153.0	COG2606@1|root,COG2606@2|Bacteria,2HH14@201174|Actinobacteria,4CP1D@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Aminoacyl-tRNA editing domain	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
TLS2_k127_4557037_13	1313172.YM304_41770	4.058e-32	141.0	COG1733@1|root,COG1733@2|Bacteria,2GMQG@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS2_k127_4557037_3	1313172.YM304_41780	7.37e-173	554.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4CNKB@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4557037_9	1123321.KB905815_gene3202	2.869e-57	209.0	COG0177@1|root,COG0177@2|Bacteria,2GNE5@201174|Actinobacteria	201174|Actinobacteria	L	PFAM HhH-GPD family protein	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
TLS2_k127_4557037_0	1121877.JQKF01000001_gene1333	0.0	1193.0	COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria,4CMQ1@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS2_k127_4557037_8	1229780.BN381_210098	1.735e-71	254.0	COG0328@1|root,COG0328@2|Bacteria,2GK53@201174|Actinobacteria,3UX0A@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DUF4440,RNase_H
TLS2_k127_4557037_18	360094.PXO_04199	0.000229	51.0	COG0484@1|root,COG0484@2|Bacteria,1QU0S@1224|Proteobacteria,1T1K9@1236|Gammaproteobacteria,1X7IH@135614|Xanthomonadales	135614|Xanthomonadales	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
TLS2_k127_4557037_15	500153.JOEK01000006_gene5329	7.426e-17	91.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_4557037_17	1384056.N787_06185	8.26e-05	55.0	COG2214@1|root,COG2214@2|Bacteria,1RC4A@1224|Proteobacteria,1T5E7@1236|Gammaproteobacteria,1XDC7@135614|Xanthomonadales	135614|Xanthomonadales	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
TLS2_k127_4557037_2	1229780.BN381_210099	1.697e-180	585.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,2GIYE@201174|Actinobacteria,3UX6P@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	EQ	Hydantoinase/oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
TLS2_k127_4557037_5	994479.GL877878_gene2267	2.009e-149	508.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4E0K0@85010|Pseudonocardiales	201174|Actinobacteria	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
TLS2_k127_45679_31	1229781.C272_03410	8.363e-13	78.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,4F886@85019|Brevibacteriaceae	201174|Actinobacteria	L	Protein of unknown function (DUF2800)	recB	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
TLS2_k127_45679_30	1229780.BN381_450026	1.69e-19	100.0	2ETCD@1|root,33KW9@2|Bacteria	2|Bacteria	S	Stress responsive	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
TLS2_k127_45679_12	471852.Tcur_3385	1.085e-101	336.0	COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria,4EMUX@85012|Streptosporangiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_45679_27	103733.JNYO01000056_gene1113	8.348e-25	118.0	COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria,4E4P1@85010|Pseudonocardiales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
TLS2_k127_45679_3	326424.FRAAL6884	1.811e-213	683.0	COG0166@1|root,COG0166@2|Bacteria,2GJG0@201174|Actinobacteria,4ETZY@85013|Frankiales	201174|Actinobacteria	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
TLS2_k127_45679_4	590998.Celf_3690	1.853e-212	681.0	COG0480@1|root,COG0480@2|Bacteria,2GKRU@201174|Actinobacteria,4F323@85016|Cellulomonadaceae	201174|Actinobacteria	J	elongation factor Tu domain 2 protein	fusA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_45679_11	326424.FRAAL3477	2.74e-110	370.0	COG0300@1|root,COG0300@2|Bacteria,2GJ1R@201174|Actinobacteria,4EU0S@85013|Frankiales	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_45679_16	1122611.KB904007_gene7764	5.13e-90	301.0	COG0346@1|root,COG0346@2|Bacteria,2HKRN@201174|Actinobacteria	2|Bacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_45679_22	1449346.JQMO01000002_gene843	1.816e-69	241.0	COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
TLS2_k127_45679_2	1123023.JIAI01000008_gene1411	2.411e-216	694.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4E1QR@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_45679_17	1211815.CBYP010000063_gene1862	1.854e-86	304.0	COG0477@1|root,COG2814@2|Bacteria,2H1TJ@201174|Actinobacteria,4EUWV@85013|Frankiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_45679_26	405948.SACE_2451	4.672e-28	119.0	COG0589@1|root,COG0589@2|Bacteria,2IQPQ@201174|Actinobacteria,4ECNY@85010|Pseudonocardiales	201174|Actinobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_45679_7	1150864.MILUP08_44872	1.526e-134	439.0	COG0276@1|root,COG0276@2|Bacteria,2GJTQ@201174|Actinobacteria,4D92F@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
TLS2_k127_45679_28	1313172.YM304_36130	1.328e-24	111.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	fldA	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
TLS2_k127_45679_19	105420.BBPO01000031_gene6631	9.015e-81	284.0	COG1120@1|root,COG1120@2|Bacteria,2IA4F@201174|Actinobacteria,2NK96@228398|Streptacidiphilus	201174|Actinobacteria	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
TLS2_k127_45679_10	390989.JOEG01000009_gene1046	2.124e-114	379.0	COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria,4D9B0@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
TLS2_k127_45679_15	1429046.RR21198_5083	2.705e-96	327.0	COG0614@1|root,COG0614@2|Bacteria,2I2MI@201174|Actinobacteria,4FW85@85025|Nocardiaceae	201174|Actinobacteria	P	Periplasmic binding protein	yvrC	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS2_k127_45679_29	1408452.JAGZ01000004_gene1613	4.44e-23	108.0	COG1309@1|root,COG1309@2|Bacteria,2GN7P@201174|Actinobacteria,233S9@1762|Mycobacteriaceae	201174|Actinobacteria	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_45679_8	518766.Rmar_2662	4.869e-129	427.0	COG1252@1|root,COG1252@2|Bacteria,4NE0H@976|Bacteroidetes,1FJ2X@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_45679_13	675635.Psed_3564	8.189e-98	334.0	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria,4E0SB@85010|Pseudonocardiales	201174|Actinobacteria	EK	Alanine-glyoxylate amino-transferase	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
TLS2_k127_45679_14	1236902.ANAS01000023_gene3284	2.537e-96	339.0	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria,4EFJQ@85012|Streptosporangiales	201174|Actinobacteria	EK	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
TLS2_k127_45679_0	1121877.JQKF01000022_gene2267	0.0	1133.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4CMX0@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS2_k127_45679_20	1457250.BBMO01000001_gene722	1.213e-76	274.0	COG1028@1|root,arCOG01259@2157|Archaea,2XUNT@28890|Euryarchaeota,23U46@183963|Halobacteria	183963|Halobacteria	I	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_45679_9	35754.JNYJ01000037_gene4689	5.558e-119	398.0	COG1609@1|root,COG1609@2|Bacteria,2IB6R@201174|Actinobacteria,4DII0@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	lacI	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
TLS2_k127_45679_5	1394178.AWOO02000012_gene3716	3.081e-171	553.0	COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_45679_24	179408.Osc7112_3402	1.004e-61	222.0	COG0580@1|root,COG0580@2|Bacteria,1G0AW@1117|Cyanobacteria,1H75V@1150|Oscillatoriales	1117|Cyanobacteria	G	Belongs to the MIP aquaporin (TC 1.A.8) family	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	iJN678.apqZ	MIP
TLS2_k127_45679_6	66874.JOFS01000017_gene3405	3.412e-157	507.0	COG0531@1|root,COG0531@2|Bacteria,2GJ75@201174|Actinobacteria	201174|Actinobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease,AA_permease_2
TLS2_k127_45679_21	1394178.AWOO02000009_gene4240	3.364e-74	259.0	COG0693@1|root,COG0693@2|Bacteria,2H6FV@201174|Actinobacteria,4EJJS@85012|Streptosporangiales	201174|Actinobacteria	S	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
TLS2_k127_45679_18	1211815.CBYP010000068_gene205	1.312e-83	301.0	COG4977@1|root,COG4977@2|Bacteria,2GM0M@201174|Actinobacteria,4EV1J@85013|Frankiales	201174|Actinobacteria	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
TLS2_k127_45679_23	1150599.MPHLEI_22279	2.079e-69	243.0	COG0596@1|root,COG0596@2|Bacteria,2GY3A@201174|Actinobacteria,236DE@1762|Mycobacteriaceae	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_45679_1	367299.JOEE01000004_gene1226	7.179e-240	754.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,4FETC@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
TLS2_k127_45679_34	1146883.BLASA_1344	0.0006382	49.0	2F62M@1|root,33YKZ@2|Bacteria,2GX5M@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_45679_32	1278078.G419_18594	4.741e-08	59.0	COG5340@1|root,COG5340@2|Bacteria,2ICBY@201174|Actinobacteria,4FZB6@85025|Nocardiaceae	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4
TLS2_k127_4665222_12	211165.AJLN01000114_gene5953	2.019e-28	125.0	COG0500@1|root,COG2226@2|Bacteria,1G4JN@1117|Cyanobacteria,1JJFD@1189|Stigonemataceae	1117|Cyanobacteria	Q	AdoMet dependent proline di-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS2_k127_4665222_10	319003.Bra1253DRAFT_07478	8.462e-44	168.0	COG0824@1|root,COG0824@2|Bacteria,1R6A6@1224|Proteobacteria,2TU6J@28211|Alphaproteobacteria,3JR33@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4665222_5	931627.MycrhDRAFT_4825	3.916e-113	384.0	COG0477@1|root,COG2814@2|Bacteria,2GIR8@201174|Actinobacteria,237SQ@1762|Mycobacteriaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_4665222_2	1313172.YM304_28400	3.44e-143	473.0	COG2132@1|root,COG4454@1|root,COG2132@2|Bacteria,COG4454@2|Bacteria,2GMJ4@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
TLS2_k127_4665222_16	882083.SacmaDRAFT_2717	4.99e-06	57.0	2B2MX@1|root,31V7F@2|Bacteria,2GV4E@201174|Actinobacteria,4E794@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4665222_0	28042.GU90_16820	2.581e-266	840.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4E2BB@85010|Pseudonocardiales	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	cutL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_4665222_9	1121423.JONT01000029_gene2383	1.964e-52	196.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia,2602K@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS2_k127_4665222_8	1313172.YM304_04660	1.131e-52	190.0	COG0245@1|root,COG0245@2|Bacteria,2II8H@201174|Actinobacteria,4CN4V@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
TLS2_k127_4665222_7	1229780.BN381_150086	3.539e-76	261.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,3UWRE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K01420,ko:K10914,ko:K21561,ko:K21564	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_4665222_11	446462.Amir_0144	6.102e-40	155.0	COG1846@1|root,COG1846@2|Bacteria,2GP6A@201174|Actinobacteria,4E4Z2@85010|Pseudonocardiales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_4665222_4	1229780.BN381_150082	9.688e-124	406.0	COG1623@1|root,COG1623@2|Bacteria,2GJ41@201174|Actinobacteria,3UX2J@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DisA bacterial checkpoint controller nucleotide-binding	disA	-	2.7.7.85	ko:K07067	-	-	-	-	ko00000,ko01000	-	-	-	DisA-linker,DisA_N,HHH,HHH_2
TLS2_k127_4665222_3	710696.Intca_0630	3.718e-132	435.0	COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria,4FF4M@85021|Intrasporangiaceae	201174|Actinobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
TLS2_k127_4665222_17	526225.Gobs_1967	0.0006222	52.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria	201174|Actinobacteria	M	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,Lactonase,TIG
TLS2_k127_4665222_14	1452718.JBOY01000190_gene845	3.196e-27	118.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4665222_13	110319.CF8_0043	3.862e-28	129.0	COG0791@1|root,COG0791@2|Bacteria,2I570@201174|Actinobacteria,4DWXE@85009|Propionibacteriales	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
TLS2_k127_4665222_6	1313172.YM304_27640	7.354e-88	297.0	COG2746@1|root,COG2746@2|Bacteria,2GNV9@201174|Actinobacteria	201174|Actinobacteria	V	aminoglycoside	-	-	2.3.1.81	ko:K00662	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Antibiotic_NAT
TLS2_k127_4665222_15	485913.Krac_7614	5.655e-27	127.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
TLS2_k127_4665222_1	1229780.BN381_150076	2.326e-232	726.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,3UWDQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	C-terminal, D2-small domain, of ClpB protein	clpC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
TLS2_k127_4692480_12	67267.JNXT01000029_gene2735	3.164e-86	290.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase type 11	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
TLS2_k127_4692480_26	1121877.JQKF01000022_gene2279	4.417e-17	84.0	2A7D0@1|root,30WA0@2|Bacteria,2HH43@201174|Actinobacteria,4CP42@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
TLS2_k127_4692480_31	1121877.JQKF01000022_gene2280	1.111e-08	66.0	COG3745@1|root,COG3745@2|Bacteria,2HH0M@201174|Actinobacteria,4CP0W@84992|Acidimicrobiia	84992|Acidimicrobiia	U	SAF	-	-	-	-	-	-	-	-	-	-	-	-	SAF
TLS2_k127_4692480_4	1229780.BN381_80287	2.908e-164	527.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,3UW7X@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	Type II/IV secretion system protein	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS2_k127_4692480_13	1229780.BN381_80286	7.271e-78	269.0	COG4965@1|root,COG4965@2|Bacteria,2I3KW@201174|Actinobacteria,3UWVZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_4692480_16	1229780.BN381_80285	1.127e-65	242.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,3UWZJ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_4692480_35	591158.SSMG_03951	0.000814	51.0	COG0515@1|root,COG0515@2|Bacteria,2ICW6@201174|Actinobacteria	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS2_k127_4692480_34	221027.JO40_00835	0.0005513	51.0	COG1652@1|root,COG1652@2|Bacteria,2J7QX@203691|Spirochaetes	203691|Spirochaetes	S	Treponemal membrane protein	tmpB	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	LysM
TLS2_k127_4692480_18	1229780.BN381_80274	9.142e-54	196.0	COG1396@1|root,COG1396@2|Bacteria,2I569@201174|Actinobacteria	201174|Actinobacteria	K	PFAM helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
TLS2_k127_4692480_20	1229780.BN381_80273	5.326e-41	160.0	COG1385@1|root,COG1385@2|Bacteria,2GTKX@201174|Actinobacteria,3UWZU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
TLS2_k127_4692480_7	1313172.YM304_21120	1.799e-124	424.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,4CMQ3@84992|Acidimicrobiia	84992|Acidimicrobiia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_4692480_8	1313172.YM304_21110	2.085e-101	349.0	COG1420@1|root,COG1420@2|Bacteria,2GKF5@201174|Actinobacteria,4CN2R@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA
TLS2_k127_4692480_25	329726.AM1_G0157	2.739e-19	102.0	COG0346@1|root,COG0346@2|Bacteria,1GG65@1117|Cyanobacteria	1117|Cyanobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_4692480_3	1380347.JNII01000012_gene2732	2.011e-167	537.0	COG0415@1|root,COG0415@2|Bacteria,2GJXU@201174|Actinobacteria,4ERIM@85013|Frankiales	201174|Actinobacteria	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
TLS2_k127_4692480_0	1313172.YM304_21060	7.091e-293	908.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4CMUT@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
TLS2_k127_4692480_27	298653.Franean1_2105	5.129e-16	80.0	COG0268@1|root,COG0268@2|Bacteria,2IQ73@201174|Actinobacteria	201174|Actinobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
TLS2_k127_4692480_14	1313172.YM304_21030	1.015e-74	271.0	COG1466@1|root,COG1466@2|Bacteria,2HGGN@201174|Actinobacteria,4CNDU@84992|Acidimicrobiia	84992|Acidimicrobiia	L	dna polymerase III delta subunit	-	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	-
TLS2_k127_4692480_10	525909.Afer_1304	4.2e-87	297.0	COG0294@1|root,COG0294@2|Bacteria,2GJNI@201174|Actinobacteria,4CNF4@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Pterin binding enzyme	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TLS2_k127_4692480_1	518766.Rmar_2012	2.666e-241	762.0	COG4263@1|root,COG4263@2|Bacteria,4NFNE@976|Bacteroidetes,1FIVE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Nitrous oxide reductase	nosZ	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	-
TLS2_k127_4692480_28	479434.Sthe_0203	3.157e-15	80.0	COG4454@1|root,COG4454@2|Bacteria,2GA6H@200795|Chloroflexi,27YMB@189775|Thermomicrobia	189775|Thermomicrobia	P	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
TLS2_k127_4692480_24	926550.CLDAP_07160	1.127e-24	121.0	COG4314@1|root,COG4314@2|Bacteria	2|Bacteria	C	lipoprotein involved in nitrous oxide reduction	nosL	-	-	ko:K19342	-	-	-	-	ko00000	-	-	-	NosL
TLS2_k127_4692480_19	479434.Sthe_0737	2.972e-45	187.0	COG1131@1|root,COG3420@1|root,COG1131@2|Bacteria,COG3420@2|Bacteria,2G7PN@200795|Chloroflexi,27Z0E@189775|Thermomicrobia	189775|Thermomicrobia	P	Domain present in carbohydrate binding proteins and sugar hydrolses	-	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	ABC_tran,NosD
TLS2_k127_4692480_22	518766.Rmar_2015	2.995e-31	138.0	COG1131@1|root,COG1131@2|Bacteria,4PER8@976|Bacteroidetes,1FJGQ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4692480_23	479434.Sthe_0738	4.15e-25	121.0	COG1277@1|root,COG1277@2|Bacteria,2G8D6@200795|Chloroflexi,27Z7V@189775|Thermomicrobia	189775|Thermomicrobia	S	ABC-2 family transporter protein	-	-	-	ko:K19341	ko02010,map02010	M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.132.2	-	-	ABC2_membrane_2
TLS2_k127_4692480_17	1313172.YM304_21020	3.554e-55	221.0	COG0658@1|root,COG0658@2|Bacteria,2GJGR@201174|Actinobacteria	201174|Actinobacteria	L	ComEC Rec2-related protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
TLS2_k127_4692480_21	1123065.ATWL01000007_gene3261	1.298e-38	154.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria	201174|Actinobacteria	L	Competence protein ComEA	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
TLS2_k127_4692480_11	1313172.YM304_20990	8.63e-87	293.0	COG3118@1|root,COG3118@2|Bacteria,2GJ7B@201174|Actinobacteria,4CMY0@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Tetratricopeptide repeat	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_20,Thioredoxin
TLS2_k127_4692480_6	1229780.BN381_10252	1.091e-124	408.0	COG3173@1|root,COG3173@2|Bacteria,2GJT0@201174|Actinobacteria,3UX9P@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_4692480_15	1229780.BN381_10251	4.89e-69	246.0	COG2047@1|root,COG2047@2|Bacteria,2GK8I@201174|Actinobacteria	201174|Actinobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
TLS2_k127_4692480_5	1313172.YM304_20970	2.05e-136	442.0	COG2141@1|root,COG2141@2|Bacteria,2GNE9@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_4692480_30	118173.KB235914_gene2745	1.451e-12	79.0	COG2373@1|root,COG2931@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,1GQCK@1117|Cyanobacteria,1HI2W@1150|Oscillatoriales	1117|Cyanobacteria	Q	Domains in Na-Ca exchangers and integrin-beta4	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Calx-beta,DUF4347,HemolysinCabind,VCBS
TLS2_k127_4692480_2	1313172.YM304_26510	4.466e-195	626.0	COG0318@1|root,COG0318@2|Bacteria	2|Bacteria	IQ	PFAM AMP-dependent synthetase and ligase	pks16	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008922,GO:0009058,GO:0009987,GO:0015645,GO:0016020,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016874,GO:0016877,GO:0016878,GO:0017076,GO:0019752,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046394,GO:0051704,GO:0070566,GO:0071704,GO:0071944,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	6.2.1.20	ko:K00666,ko:K01909	ko00071,map00071	-	R01406	RC00014,RC00039	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C,AMP-binding_C_2
TLS2_k127_4692480_33	1229172.JQFA01000005_gene87	8.183e-06	49.0	2E9VC@1|root,33416@2|Bacteria,1G9EI@1117|Cyanobacteria,1HCF9@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4740678_3	1229780.BN381_10049	6.965e-124	399.0	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,3UW86@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS2_k127_4740678_18	1313172.YM304_10670	5.757e-22	108.0	COG0355@1|root,COG0355@2|Bacteria	2|Bacteria	C	proton-transporting ATP synthase activity, rotational mechanism	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iLJ478.TM1609	ATP-synt_DE,ATP-synt_DE_N
TLS2_k127_4740678_7	1223523.H340_03834	6.93e-105	357.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_4740678_15	1123251.ATWM01000002_gene360	7.473e-34	138.0	COG1145@1|root,32SB1@2|Bacteria,2IJFQ@201174|Actinobacteria,4FH5C@85021|Intrasporangiaceae	201174|Actinobacteria	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF326
TLS2_k127_4740678_8	1122221.JHVI01000013_gene2784	2.451e-98	327.0	COG2326@1|root,COG2326@2|Bacteria,1WKEJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
TLS2_k127_4740678_20	706439.HMPREF9057_01638	5.078e-15	86.0	COG1514@1|root,COG1514@2|Bacteria,2GRF0@201174|Actinobacteria,4D3IN@85005|Actinomycetales	201174|Actinobacteria	J	2',5' RNA ligase family protein	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
TLS2_k127_4740678_2	1463845.JOIG01000010_gene2226	2.177e-140	452.0	COG1494@1|root,COG1494@2|Bacteria,2GMQU@201174|Actinobacteria	201174|Actinobacteria	G	Fructose-1,6-bisphosphatase	glpX	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
TLS2_k127_4740678_19	1229780.BN381_10055	3.328e-19	98.0	294NP@1|root,2ZS20@2|Bacteria,2H9SR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4740678_13	1229780.BN381_10056	3.86e-58	209.0	COG2214@1|root,COG2214@2|Bacteria,2H5PV@201174|Actinobacteria	201174|Actinobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4740678_12	446471.Xcel_0359	3.583e-65	238.0	COG3571@1|root,COG3571@2|Bacteria,2GKKE@201174|Actinobacteria,4F4CP@85017|Promicromonosporaceae	201174|Actinobacteria	S	Hydrolase of the alpha beta-hydrolase	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	DLH
TLS2_k127_4740678_9	1229780.BN381_10060	1.053e-87	310.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1	-	-	MFS_1,Sugar_tr
TLS2_k127_4740678_17	1313172.YM304_10770	5.581e-26	110.0	COG0694@1|root,COG0694@2|Bacteria,2HGE4@201174|Actinobacteria,4CNCF@84992|Acidimicrobiia	84992|Acidimicrobiia	O	NifU-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NifU
TLS2_k127_4740678_5	1313172.YM304_10780	1.184e-112	372.0	COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria,4CMYQ@84992|Acidimicrobiia	84992|Acidimicrobiia	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS2_k127_4740678_10	1463909.KL585983_gene5858	2.374e-85	295.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	lipP	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_4740678_4	1206733.BAGC01000052_gene2494	3.203e-113	370.0	COG1024@1|root,COG1024@2|Bacteria,2GKJ6@201174|Actinobacteria,4G041@85025|Nocardiaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.149,4.2.1.17	ko:K01692,ko:K08299	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093,R10675	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1,Polyketide_cyc2
TLS2_k127_4740678_6	1313172.YM304_17100	1.016e-111	372.0	COG1028@1|root,COG1028@2|Bacteria,2HFKT@201174|Actinobacteria,4CNUQ@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_4740678_0	1313172.YM304_17090	2.48e-239	752.0	COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,4CP51@84992|Acidimicrobiia	201174|Actinobacteria	IQ	Protein synonym acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_4740678_14	1120936.KB907221_gene2166	1.398e-45	172.0	COG1309@1|root,COG1309@2|Bacteria,2IBKZ@201174|Actinobacteria	201174|Actinobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
TLS2_k127_4740678_16	1313172.YM304_17070	6.137e-33	132.0	COG1545@1|root,COG1545@2|Bacteria	2|Bacteria	I	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_4740678_1	1313172.YM304_17060	7.848e-186	593.0	COG0183@1|root,COG0183@2|Bacteria,2IGBX@201174|Actinobacteria	201174|Actinobacteria	I	Thiolase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_4740678_11	1313172.YM304_10790	2.738e-67	233.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,4CMYM@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_4743016_9	446469.Sked_28260	8.855e-07	61.0	COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria	201174|Actinobacteria	V	HNH endonuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_4743016_5	711393.AYRX01000009_gene2435	4.176e-39	156.0	COG0500@1|root,COG2226@2|Bacteria,2GP9N@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_4743016_3	1313172.YM304_31180	2.766e-70	248.0	COG1121@1|root,COG1121@2|Bacteria,2GN95@201174|Actinobacteria	201174|Actinobacteria	P	ABC transporter	-	-	-	ko:K11603	ko02010,ko02020,map02010,map02020	M00316	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.1	-	-	ABC_tran
TLS2_k127_4743016_1	222534.KB893771_gene4733	4.855e-223	716.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4ERWA@85013|Frankiales	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpE	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
TLS2_k127_4743016_6	1463887.KL590052_gene5200	8.219e-38	166.0	COG3550@1|root,COG3550@2|Bacteria,2GJ1X@201174|Actinobacteria	201174|Actinobacteria	S	MDMPI C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
TLS2_k127_4743016_2	1229780.BN381_100183	2.501e-103	346.0	COG1191@1|root,COG1191@2|Bacteria,2GKBK@201174|Actinobacteria	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_4743016_4	1313172.YM304_00110	2.566e-57	212.0	COG1748@1|root,COG1748@2|Bacteria,2H8X8@201174|Actinobacteria	201174|Actinobacteria	E	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4743016_7	1229780.BN381_100174	2.075e-24	111.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF3566
TLS2_k127_4743016_0	1229780.BN381_100172	3.058e-226	716.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,3UWEZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS2_k127_4755639_10	1229780.BN381_640016	1.267e-22	100.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	bglIM	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
TLS2_k127_4755639_11	326298.Suden_0122	1.15e-17	96.0	2BUAB@1|root,32PJW@2|Bacteria,1Q49J@1224|Proteobacteria,42YP0@68525|delta/epsilon subdivisions,2YR52@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4755639_2	1502850.FG91_02580	5.325e-102	336.0	COG0655@1|root,COG0655@2|Bacteria,1N5Q7@1224|Proteobacteria,2U5RW@28211|Alphaproteobacteria,2K2NJ@204457|Sphingomonadales	204457|Sphingomonadales	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS2_k127_4755639_1	298655.KI912266_gene1939	1.799e-118	388.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4ERP0@85013|Frankiales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
TLS2_k127_4755639_3	68170.KL590533_gene5260	1.37e-71	256.0	COG0842@1|root,COG0842@2|Bacteria,2IART@201174|Actinobacteria,4E1XJ@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
TLS2_k127_4755639_4	1229780.BN381_100072	8.96e-63	243.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_4755639_12	1123322.KB904693_gene4542	9.409e-06	57.0	2EP2Q@1|root,33GPI@2|Bacteria,2I8SN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4755639_7	1445613.JALM01000074_gene6668	2.832e-45	171.0	COG0454@1|root,COG0456@2|Bacteria,2GUV2@201174|Actinobacteria	201174|Actinobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_4755639_0	1048339.KB913029_gene1599	1.878e-189	617.0	COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4ERFB@85013|Frankiales	201174|Actinobacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
TLS2_k127_4755639_6	1313172.YM304_42610	7.92e-46	170.0	COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria,4CNBU@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
TLS2_k127_4755639_8	1229780.BN381_100141	1.168e-35	140.0	COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,3UWV6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
TLS2_k127_4755639_5	1229780.BN381_100142	1.071e-47	175.0	COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,3UWQD@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Single-strand binding protein family	ssb	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_4755639_9	1229780.BN381_100143	5.503e-30	124.0	COG0360@1|root,COG0360@2|Bacteria,2IQHD@201174|Actinobacteria,3UWQU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
TLS2_k127_4779934_1	525909.Afer_0286	2.219e-122	408.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4CNI4@84992|Acidimicrobiia	84992|Acidimicrobiia	JKL	DEAD-like helicases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
TLS2_k127_4779934_4	397278.JOJN01000005_gene870	3.896e-35	151.0	COG0840@1|root,COG0840@2|Bacteria,2I44N@201174|Actinobacteria	201174|Actinobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
TLS2_k127_4779934_3	1313172.YM304_10080	8.447e-46	169.0	COG0347@1|root,COG0347@2|Bacteria,2IKN1@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the P(II) protein family	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
TLS2_k127_4779934_0	1293054.HSACCH_00677	3.753e-123	413.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,3WBKG@53433|Halanaerobiales	186801|Clostridia	P	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,P-II
TLS2_k127_4779934_5	645465.ACUR01000507_gene410	1.024e-32	136.0	COG0745@1|root,COG0745@2|Bacteria,2IQB8@201174|Actinobacteria	201174|Actinobacteria	KT	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Trans_reg_C
TLS2_k127_4779934_2	1313172.YM304_39270	3.388e-47	174.0	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,2GJ7M@201174|Actinobacteria,4CMWD@84992|Acidimicrobiia	84992|Acidimicrobiia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
TLS2_k127_4782938_4	47839.CCAU010000015_gene4203	5.329e-121	400.0	COG0657@1|root,COG0657@2|Bacteria,2GTEV@201174|Actinobacteria,232VN@1762|Mycobacteriaceae	201174|Actinobacteria	I	esterase	lipM	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS2_k127_4782938_6	1123023.JIAI01000004_gene8250	6.317e-45	184.0	COG0511@1|root,COG0511@2|Bacteria,2GMCA@201174|Actinobacteria,4E2PV@85010|Pseudonocardiales	201174|Actinobacteria	I	MDMPI C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
TLS2_k127_4782938_3	164757.Mjls_0414	1.29e-128	431.0	COG2197@1|root,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria,233VG@1762|Mycobacteriaceae	201174|Actinobacteria	K	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_4782938_5	512565.AMIS_23690	3.654e-71	256.0	COG1960@1|root,COG1960@2|Bacteria,2GMKM@201174|Actinobacteria,4DC7I@85008|Micromonosporales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.14.13.235	ko:K22027	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
TLS2_k127_4782938_2	1246448.ANAZ01000011_gene591	3.209e-162	519.0	COG2519@1|root,COG2519@2|Bacteria,2GMKZ@201174|Actinobacteria,4EI8Y@85012|Streptosporangiales	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_4782938_0	706587.Desti_3688	1.879e-205	676.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,43BFQ@68525|delta/epsilon subdivisions,2X6U4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	pfam fad	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_4782938_1	1246448.ANAZ01000011_gene592	3.999e-172	557.0	COG2909@1|root,COG2909@2|Bacteria,2I3S2@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_4782938_8	1229780.BN381_250015	1.783e-39	151.0	COG3945@1|root,COG3945@2|Bacteria	2|Bacteria	P	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS2_k127_4782938_9	1415166.NONO_c10020	7.16e-05	55.0	COG3266@1|root,COG3827@1|root,COG3266@2|Bacteria,COG3827@2|Bacteria,2GNDT@201174|Actinobacteria,4G0Z6@85025|Nocardiaceae	201174|Actinobacteria	D	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	ADPrib_exo_Tox,Endonuclea_NS_2
TLS2_k127_482912_1	1469613.JT55_07845	1.743e-149	481.0	COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2TRB8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CH	4-hydroxybenzoate	pobA	-	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
TLS2_k127_482912_2	1232683.ADIMK_0092	6.751e-140	451.0	COG0673@1|root,COG0673@2|Bacteria,1MXUP@1224|Proteobacteria,1RP9K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	dehydrogenases and related proteins	ligC	-	1.1.1.312	ko:K10219	ko00350,ko00362,ko00627,ko01120,ko01220,map00350,map00362,map00627,map01120,map01220	M00533	R04278,R04279,R04418,R04419	RC00251,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_482912_5	926564.KI911697_gene291	1.534e-44	182.0	COG1802@1|root,COG1802@2|Bacteria,2IBT4@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_482912_7	1003195.SCAT_4670	2.469e-32	128.0	COG1725@1|root,COG1725@2|Bacteria,2IHTD@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
TLS2_k127_482912_10	1158050.KB895454_gene1612	0.0008485	51.0	2DMCI@1|root,32JTK@2|Bacteria,2IT25@201174|Actinobacteria,1W9YE@1268|Micrococcaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_482912_8	471853.Bcav_0108	3.442e-31	135.0	2F2DM@1|root,33VBA@2|Bacteria,2HHW0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648
TLS2_k127_482912_4	566466.NOR53_932	9.598e-74	257.0	COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,1RW94@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,NAD_binding_2
TLS2_k127_482912_3	649831.L083_3805	6.45e-87	293.0	COG0684@1|root,COG0684@2|Bacteria,2I8VQ@201174|Actinobacteria,4DCVQ@85008|Micromonosporales	201174|Actinobacteria	H	Aldolase/RraA	ligK	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
TLS2_k127_482912_0	1116375.VEJY3_18091	3.195e-164	524.0	COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,1RMYJ@1236|Gammaproteobacteria,1XVYI@135623|Vibrionales	135623|Vibrionales	S	Amidohydrolase	-	-	4.2.1.83	ko:K10220	ko00362,ko01120,map00362,map01120	-	R04478	RC00498	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
TLS2_k127_482912_6	1121272.KB903251_gene824	2.059e-39	154.0	COG0454@1|root,COG0456@2|Bacteria,2IAC7@201174|Actinobacteria,4DJN8@85008|Micromonosporales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	aac	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008080,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016020,GO:0016137,GO:0016139,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017001,GO:0017144,GO:0030647,GO:0030649,GO:0034069,GO:0044237,GO:0044248,GO:0044464,GO:0047921,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658	2.3.1.59	ko:K17840	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_9
TLS2_k127_482912_9	1172188.KB911821_gene1205	9.273e-20	92.0	COG3154@1|root,COG3154@2|Bacteria,2I75S@201174|Actinobacteria,4FG6A@85021|Intrasporangiaceae	201174|Actinobacteria	I	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS2_k127_4834307_1	1122611.KB903955_gene5476	3.428e-76	256.0	COG0447@1|root,COG0447@2|Bacteria,2GK5G@201174|Actinobacteria,4EI6I@85012|Streptosporangiales	201174|Actinobacteria	H	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)	menB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016043,GO:0016829,GO:0016830,GO:0016833,GO:0022607,GO:0034214,GO:0042180,GO:0042181,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576,GO:1901661,GO:1901663	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_4834307_0	1348657.M622_04915	4.89e-258	824.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,2KVJS@206389|Rhodocyclales	206389|Rhodocyclales	P	Cation transport ATPase (P-type)	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
TLS2_k127_4834307_2	1380356.JNIK01000002_gene4858	1.706e-54	196.0	COG2259@1|root,COG2259@2|Bacteria,2IJ0I@201174|Actinobacteria,4ET1G@85013|Frankiales	201174|Actinobacteria	S	PFAM DoxX family protein	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
TLS2_k127_4871533_6	285514.JNWO01000003_gene7010	1.502e-107	357.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	sigI	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4871533_11	227882.SAV_960	1.124e-78	270.0	COG3795@1|root,COG3795@2|Bacteria,2IFD6@201174|Actinobacteria	201174|Actinobacteria	V	PFAM YCII-related	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_4871533_16	1313172.YM304_04330	2.901e-57	208.0	COG4270@1|root,COG4270@2|Bacteria,2IKKP@201174|Actinobacteria	201174|Actinobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
TLS2_k127_4871533_3	187272.Mlg_2709	2.619e-171	544.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,1RP2I@1236|Gammaproteobacteria,1WXCD@135613|Chromatiales	135613|Chromatiales	P	TIGRFAM Arsenical-resistance protein	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
TLS2_k127_4871533_17	1122138.AQUZ01000094_gene5511	2.239e-56	203.0	COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria,4DQUH@85009|Propionibacteriales	201174|Actinobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS2_k127_4871533_15	103733.JNYO01000017_gene3123	1.512e-59	213.0	COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,2IB1N@201174|Actinobacteria,4E6RW@85010|Pseudonocardiales	201174|Actinobacteria	KT	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,LMWPc
TLS2_k127_4871533_5	1121926.AXWO01000004_gene1022	1.184e-144	479.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4EYA2@85014|Glycomycetales	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1079	Cys_Met_Meta_PP
TLS2_k127_4871533_2	1160137.KB907307_gene4317	5.994e-180	579.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,2GIXE@201174|Actinobacteria,4FU9S@85025|Nocardiaceae	201174|Actinobacteria	EK	Cystathionine beta-synthase	cbs	GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
TLS2_k127_4871533_13	44060.JODL01000024_gene345	9.511e-72	252.0	COG0262@1|root,COG0262@2|Bacteria,2GYU7@201174|Actinobacteria	201174|Actinobacteria	H	bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_4871533_1	1394178.AWOO02000100_gene8296	1.908e-206	693.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4EHI3@85012|Streptosporangiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_4871533_0	1078020.KEK_05697	1.561e-248	771.0	COG1960@1|root,COG1960@2|Bacteria,2IBSE@201174|Actinobacteria,233FW@1762|Mycobacteriaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_4871533_4	2074.JNYD01000001_gene5859	1.421e-148	481.0	COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,4DYE9@85010|Pseudonocardiales	201174|Actinobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_4871533_21	479432.Sros_3231	4.954e-10	70.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4EGDE@85012|Streptosporangiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4871533_10	1068980.ARVW01000001_gene557	1.389e-85	291.0	COG0640@1|root,COG0640@2|Bacteria,2GJT9@201174|Actinobacteria,4E1BA@85010|Pseudonocardiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_4871533_14	1068980.ARVW01000001_gene560	1.201e-70	246.0	COG3832@1|root,COG3832@2|Bacteria,2HQ66@201174|Actinobacteria,4E36Q@85010|Pseudonocardiales	201174|Actinobacteria	S	Pfam Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_4871533_9	1101188.KI912155_gene2605	7.479e-86	291.0	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,1WCGJ@1268|Micrococcaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fabG3	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0016020,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0033764,GO:0044238,GO:0044464,GO:0047044,GO:0055114,GO:0071704,GO:0071944,GO:1901360	1.1.1.53	ko:K00038	ko00140,ko01100,map00140,map01100	-	R04831,R04834,R04844,R04847	RC00139,RC01219,RC01220	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
TLS2_k127_4871533_8	196162.Noca_2053	4.153e-87	290.0	COG2514@1|root,COG2514@2|Bacteria,2I4TW@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_4871533_12	1229780.BN381_60058	4.744e-77	262.0	COG2353@1|root,COG2353@2|Bacteria,2GJUB@201174|Actinobacteria,3UWSE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	YceI-like domain	yceI	-	-	-	-	-	-	-	-	-	-	-	YceI
TLS2_k127_4871533_19	358823.DF19_12500	4.025e-43	162.0	COG1846@1|root,COG1846@2|Bacteria,2GP6A@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS2_k127_4871533_20	1449069.JMLO01000006_gene1051	1.862e-18	90.0	2DFAP@1|root,2ZR44@2|Bacteria,2H7P6@201174|Actinobacteria,4G3B2@85025|Nocardiaceae	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS2_k127_4871533_18	37919.EP51_00130	1.086e-46	175.0	COG1309@1|root,COG1309@2|Bacteria,2GM45@201174|Actinobacteria,4FXEM@85025|Nocardiaceae	201174|Actinobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
TLS2_k127_4871533_7	443218.AS9A_2330	5.631e-99	342.0	COG3324@1|root,COG3324@2|Bacteria,2GJFC@201174|Actinobacteria,237FD@1762|Mycobacteriaceae	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_4876991_4	2045.KR76_20660	7.558e-30	136.0	COG1917@1|root,COG1917@2|Bacteria,2IQ74@201174|Actinobacteria	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4876991_3	1237500.ANBA01000008_gene189	7.662e-32	132.0	COG1309@1|root,COG1309@2|Bacteria,2IMJ7@201174|Actinobacteria,4EP4T@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_4876991_1	391625.PPSIR1_22069	7.536e-47	178.0	COG0789@1|root,COG0789@2|Bacteria,1N1YK@1224|Proteobacteria	1224|Proteobacteria	K	Regulatory protein, MerR	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_4876991_0	1380390.JIAT01000010_gene4081	7.995e-103	345.0	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,4CSBE@84995|Rubrobacteria	84995|Rubrobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_4876991_2	1048339.KB913029_gene3842	4.49e-45	170.0	COG2764@1|root,COG2764@2|Bacteria,2IKY5@201174|Actinobacteria,4ET8M@85013|Frankiales	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
TLS2_k127_4908356_5	357808.RoseRS_3276	8.324e-87	296.0	COG2308@1|root,COG2308@2|Bacteria,2GACA@200795|Chloroflexi,37575@32061|Chloroflexia	32061|Chloroflexia	S	A circularly permuted ATPgrasp	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
TLS2_k127_4908356_19	1463853.JOHW01000011_gene3480	0.0003634	47.0	29AEY@1|root,2ZXFA@2|Bacteria,2GQQN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LapA_dom
TLS2_k127_4908356_4	1229780.BN381_210105	2.202e-93	323.0	COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria,3UWMW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
TLS2_k127_4908356_11	1068978.AMETH_4808	5.587e-47	173.0	COG3832@1|root,COG3832@2|Bacteria,2IFJT@201174|Actinobacteria,4E4TI@85010|Pseudonocardiales	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_4908356_3	298655.KI912266_gene6144	5.15e-110	361.0	COG1028@1|root,COG1028@2|Bacteria,2GNUM@201174|Actinobacteria,4EUM8@85013|Frankiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
TLS2_k127_4908356_10	1278073.MYSTI_00204	4.674e-48	189.0	COG1232@1|root,COG1232@2|Bacteria,1RFQU@1224|Proteobacteria,43CYS@68525|delta/epsilon subdivisions,2X86X@28221|Deltaproteobacteria,2Z3MD@29|Myxococcales	28221|Deltaproteobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS2_k127_4908356_8	235985.BBPN01000027_gene1608	3.507e-61	223.0	COG1595@1|root,COG1595@2|Bacteria,2GKBH@201174|Actinobacteria,2NFK5@228398|Streptacidiphilus	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
TLS2_k127_4908356_16	1229780.BN381_60087	4.148e-25	112.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	GGDEF,HTH_Crp_2,cNMP_binding
TLS2_k127_4908356_17	593907.Celgi_0909	1.278e-23	106.0	2AWFS@1|root,31NC1@2|Bacteria,2IMS0@201174|Actinobacteria,4F1EB@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4908356_7	1313172.YM304_41590	1.156e-68	239.0	COG0218@1|root,COG0218@2|Bacteria	2|Bacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
TLS2_k127_4908356_13	700508.D174_15150	1.168e-38	155.0	COG1188@1|root,COG1188@2|Bacteria,2IQ6F@201174|Actinobacteria,239GS@1762|Mycobacteriaceae	201174|Actinobacteria	J	heat shock protein	hslR	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
TLS2_k127_4908356_14	1122223.KB890700_gene2086	4.021e-31	127.0	COG2010@1|root,COG2010@2|Bacteria,1WMT3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
TLS2_k127_4908356_15	1313172.YM304_31470	2.878e-29	131.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_4908356_18	1205680.CAKO01000040_gene1069	8.142e-23	102.0	2E474@1|root,32Z30@2|Bacteria,1NGK4@1224|Proteobacteria,2UKT6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4908356_9	1123023.JIAI01000001_gene6160	5.455e-61	214.0	COG2030@1|root,COG2030@2|Bacteria,2HG1J@201174|Actinobacteria,4EB3Y@85010|Pseudonocardiales	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS2_k127_4908356_6	1121377.KB906399_gene1726	4.819e-71	252.0	COG2301@1|root,COG2301@2|Bacteria	2|Bacteria	G	Belongs to the HpcH HpaI aldolase family	citE	GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006107,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046872,GO:0071704	4.1.3.25,4.1.3.34	ko:K01644,ko:K18292	ko00660,ko01100,ko02020,map00660,map01100,map02020	-	R00237,R00362	RC00067,RC00502,RC01118,RC01205	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_4908356_12	479432.Sros_8185	3.854e-43	162.0	COG1522@1|root,COG1522@2|Bacteria,2GMSR@201174|Actinobacteria,4EJYK@85012|Streptosporangiales	201174|Actinobacteria	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS2_k127_4908356_1	350058.Mvan_4086	8.371e-137	444.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,234HF@1762|Mycobacteriaceae	201174|Actinobacteria	C	Dehydrogenase E1 component	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS2_k127_4908356_0	222534.KB893715_gene1681	4.534e-169	539.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4ES0E@85013|Frankiales	201174|Actinobacteria	C	PFAM Transketolase central region	pdhB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2496c	Transket_pyr,Transketolase_C
TLS2_k127_4908356_2	222534.KB893715_gene1680	9.656e-130	438.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria,4ERC0@85013|Frankiales	201174|Actinobacteria	C	of components of various dehydrogenase complexes	pdhC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_4974709_4	1206737.BAGF01000042_gene2661	1.577e-85	301.0	COG4398@1|root,COG4398@2|Bacteria,2I3VH@201174|Actinobacteria,4FXH9@85025|Nocardiaceae	201174|Actinobacteria	S	FIST N domain	-	GO:0008150,GO:0040007	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
TLS2_k127_4974709_0	706587.Desti_3139	2.459e-183	594.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria,2MQIA@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the transketolase family	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TLS2_k127_4974709_1	1120949.KB903294_gene3987	4.34e-131	428.0	COG0176@1|root,COG0176@2|Bacteria,2GMF9@201174|Actinobacteria,4D9UT@85008|Micromonosporales	201174|Actinobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TLS2_k127_4974709_8	118163.Ple7327_2520	6.113e-33	136.0	COG0363@1|root,COG0363@2|Bacteria,1G20H@1117|Cyanobacteria,3VI27@52604|Pleurocapsales	1117|Cyanobacteria	G	PFAM Glucosamine-6-phosphate isomerases 6-phosphogluconolactonase	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
TLS2_k127_4974709_3	1229780.BN381_10337	9.486e-91	321.0	COG1611@1|root,COG1611@2|Bacteria,2GKJH@201174|Actinobacteria,3UXFN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TLS2_k127_4974709_7	452652.KSE_73220	8.57e-37	148.0	COG0645@1|root,COG0645@2|Bacteria	2|Bacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
TLS2_k127_4974709_2	1313172.YM304_26330	1.662e-117	390.0	COG0247@1|root,COG0247@2|Bacteria,2GIVX@201174|Actinobacteria,4CN2B@84992|Acidimicrobiia	84992|Acidimicrobiia	C	4Fe-4S dicluster domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7
TLS2_k127_4974709_5	1313172.YM304_26370	2.692e-56	204.0	COG0277@1|root,COG0277@2|Bacteria,2H3K3@201174|Actinobacteria,4CNDA@84992|Acidimicrobiia	84992|Acidimicrobiia	C	FAD binding domain	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD_binding_4
TLS2_k127_503265_36	1463845.JOIG01000008_gene3690	3.662e-17	87.0	COG4586@1|root,COG4586@2|Bacteria,2GKSX@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,ArgK
TLS2_k127_503265_23	68219.JNXI01000005_gene6453	9.576e-63	225.0	COG3694@1|root,COG3694@2|Bacteria,2GMBG@201174|Actinobacteria	201174|Actinobacteria	S	transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
TLS2_k127_503265_17	1944.JOAZ01000015_gene4558	4.798e-76	263.0	COG4587@1|root,COG4587@2|Bacteria,2GKX7@201174|Actinobacteria,419FJ@629295|Streptomyces griseus group	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
TLS2_k127_503265_26	1313172.YM304_23350	1.536e-44	172.0	COG3428@1|root,COG3428@2|Bacteria,2HGDA@201174|Actinobacteria,4CNBH@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT,bPH_2
TLS2_k127_503265_25	543632.JOJL01000016_gene8971	2.059e-46	172.0	COG0242@1|root,COG0242@2|Bacteria,2HMJS@201174|Actinobacteria,4DBU9@85008|Micromonosporales	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TLS2_k127_503265_32	1232410.KI421428_gene1086	3.171e-31	130.0	COG2716@1|root,COG2716@2|Bacteria,1RB6J@1224|Proteobacteria,42R2M@68525|delta/epsilon subdivisions,2WMWP@28221|Deltaproteobacteria,43SFC@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	ACT domain	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT,ACT_6
TLS2_k127_503265_27	1209984.BN978_02425	4.687e-42	157.0	COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria,23A0S@1762|Mycobacteriaceae	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
TLS2_k127_503265_4	1229780.BN381_10320	8.066e-175	576.0	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria,3UW87@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	UvrD-like helicase C-terminal domain	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
TLS2_k127_503265_16	1313172.YM304_21850	4.552e-77	275.0	COG1108@1|root,COG1108@2|Bacteria,2GJ7H@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Mn2 Zn2 transport systems permease components	mntB	-	-	ko:K02075,ko:K09819	-	M00243,M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
TLS2_k127_503265_20	1404245.CGLY_01880	2.99e-65	236.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,22RDP@1653|Corynebacteriaceae	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	mntC	-	-	ko:K02077	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
TLS2_k127_503265_29	1229780.BN381_10319	3.378e-38	159.0	COG2050@1|root,COG2050@2|Bacteria,2I11Y@201174|Actinobacteria,3UXR4@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_503265_14	1313172.YM304_23330	3.074e-91	332.0	COG0708@1|root,COG0708@2|Bacteria,2GKEW@201174|Actinobacteria,4CN0I@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Endonuclease/Exonuclease/phosphatase family	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
TLS2_k127_503265_0	1313172.YM304_23290	0.0	1595.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4CMWS@84992|Acidimicrobiia	84992|Acidimicrobiia	C	2-oxoglutarate dehydrogenase N-terminus	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
TLS2_k127_503265_38	1120950.KB892771_gene1280	2.242e-13	80.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx,Pyridox_ox_2
TLS2_k127_503265_18	402881.Plav_0030	1.82e-71	247.0	COG1011@1|root,COG1011@2|Bacteria,1Q69X@1224|Proteobacteria,2TTTP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	hydrolase	MA20_23095	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
TLS2_k127_503265_10	1229780.BN381_10314	9.144e-99	336.0	COG0539@1|root,COG0539@2|Bacteria,2I7V9@201174|Actinobacteria	201174|Actinobacteria	J	Zc3h12a-like Ribonuclease NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	HC2,RNase_Zc3h12a
TLS2_k127_503265_1	1229780.BN381_10313	1.086e-289	904.0	COG0488@1|root,COG0488@2|Bacteria,2GKBQ@201174|Actinobacteria,3UWE5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	ABC transporter	yjjK	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
TLS2_k127_503265_15	1206720.BAFQ01000293_gene6399	1.003e-81	286.0	COG1218@1|root,COG1218@2|Bacteria,2GMW7@201174|Actinobacteria,4FYAJ@85025|Nocardiaceae	201174|Actinobacteria	P	Inositol monophosphatase family	cysQ	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
TLS2_k127_503265_2	1313172.YM304_27360	1.37e-204	657.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4CMUC@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
TLS2_k127_503265_13	1229780.BN381_10284	4.89e-92	326.0	COG1637@1|root,COG1637@2|Bacteria,2GIYB@201174|Actinobacteria,3UWH6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
TLS2_k127_503265_28	653045.Strvi_4893	1.241e-41	169.0	COG0500@1|root,COG0500@2|Bacteria,2I3FS@201174|Actinobacteria	201174|Actinobacteria	Q	Pfam Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_503265_21	1267535.KB906767_gene2002	7.371e-63	221.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,TPMT
TLS2_k127_503265_35	1027273.GZ77_10270	1.704e-20	102.0	COG0615@1|root,COG0615@2|Bacteria	2|Bacteria	H	ADP-L-glycero-beta-D-manno-heptose biosynthetic process	-	-	2.7.7.39	ko:K00980	ko00564,map00564	-	R00856	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
TLS2_k127_503265_33	219305.MCAG_03981	1.343e-27	119.0	COG1670@1|root,COG1670@2|Bacteria,2GNYE@201174|Actinobacteria,4DA8Y@85008|Micromonosporales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_503265_34	743718.Isova_0883	6.867e-25	115.0	COG0666@1|root,COG0666@2|Bacteria,2I3AT@201174|Actinobacteria,4F52A@85017|Promicromonosporaceae	201174|Actinobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_503265_8	1280952.HJA_16191	3.477e-114	374.0	COG2030@1|root,COG2030@2|Bacteria,1MUR2@1224|Proteobacteria	1224|Proteobacteria	I	Dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
TLS2_k127_503265_7	1229780.BN381_250119	5.5e-129	422.0	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,3UX8U@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	IQ	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
TLS2_k127_503265_19	1229780.BN381_10280	2.636e-65	246.0	COG2720@1|root,COG2720@2|Bacteria,2GISH@201174|Actinobacteria,3UXFH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	V	VanW like protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
TLS2_k127_503265_9	1313172.YM304_15790	2.507e-113	385.0	COG0644@1|root,COG0644@2|Bacteria,2GMH9@201174|Actinobacteria	201174|Actinobacteria	C	geranylgeranyl reductase	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
TLS2_k127_503265_6	1229780.BN381_10277	1.519e-136	444.0	COG2070@1|root,COG2070@2|Bacteria,2GKA6@201174|Actinobacteria,3UXGG@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	NMO
TLS2_k127_503265_5	1229780.BN381_80259	2.862e-145	469.0	COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_503265_3	1229780.BN381_80237	2.131e-177	564.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_503265_24	1313172.YM304_15510	4.432e-53	200.0	COG2267@1|root,COG2267@2|Bacteria,2HGVY@201174|Actinobacteria,4CNX3@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_503265_31	1313172.YM304_15490	4.783e-35	152.0	COG0671@1|root,COG0671@2|Bacteria,2HGAE@201174|Actinobacteria,4CN9F@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
TLS2_k127_503265_22	1283283.ATXA01000008_gene3129	8.324e-63	226.0	COG1651@1|root,COG1651@2|Bacteria,2IT6U@201174|Actinobacteria	201174|Actinobacteria	O	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
TLS2_k127_503265_11	1229780.BN381_80224	4.915e-95	328.0	COG1020@1|root,COG1020@2|Bacteria,2GKU0@201174|Actinobacteria	201174|Actinobacteria	Q	diacylglycerol O-acyltransferase	-	GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
TLS2_k127_503265_12	247633.GP2143_12221	1.926e-93	314.0	COG4221@1|root,COG4221@2|Bacteria,1MW86@1224|Proteobacteria,1SMC5@1236|Gammaproteobacteria,1J7M9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_503265_30	1286171.EAL2_c07920	6.994e-37	159.0	COG4907@1|root,COG4907@2|Bacteria,1TS3Q@1239|Firmicutes,25CFE@186801|Clostridia	186801|Clostridia	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
TLS2_k127_503265_41	526225.Gobs_2271	4.022e-06	58.0	COG3663@1|root,COG3663@2|Bacteria,2GNS5@201174|Actinobacteria,4ESR4@85013|Frankiales	201174|Actinobacteria	L	PFAM Uracil-DNA glycosylase superfamily	mug	-	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_5058654_16	66875.JODY01000006_gene2209	2.196e-44	167.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the amidase family	amiC_1	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS2_k127_5058654_23	189753.AXAS01000060_gene8317	1.971e-14	76.0	COG2388@1|root,COG2388@2|Bacteria,1N8AQ@1224|Proteobacteria,2UFVS@28211|Alphaproteobacteria,3K0T0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	GCN5-related N-acetyl-transferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
TLS2_k127_5058654_9	356851.JOAN01000004_gene1125	4.564e-94	320.0	COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria,4DDZ9@85008|Micromonosporales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
TLS2_k127_5058654_2	351607.Acel_0139	1.925e-225	730.0	COG3408@1|root,COG3408@2|Bacteria,2GIUI@201174|Actinobacteria,4EUUE@85013|Frankiales	201174|Actinobacteria	G	N-terminal domain of (some) glycogen debranching enzymes	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
TLS2_k127_5058654_6	525909.Afer_0361	2.767e-117	388.0	COG0438@1|root,COG0438@2|Bacteria,2I005@201174|Actinobacteria	201174|Actinobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_5058654_22	1246448.ANAZ01000008_gene2408	1.124e-14	87.0	COG0239@1|root,COG0239@2|Bacteria,2IKM1@201174|Actinobacteria,4EKJW@85012|Streptosporangiales	201174|Actinobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TLS2_k127_5058654_20	926550.CLDAP_31200	3.096e-17	92.0	COG0239@1|root,COG0239@2|Bacteria,2G760@200795|Chloroflexi	200795|Chloroflexi	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TLS2_k127_5058654_12	35754.JNYJ01000014_gene4862	6.539e-74	279.0	COG1835@1|root,COG2755@1|root,COG1835@2|Bacteria,COG2755@2|Bacteria,2GKI5@201174|Actinobacteria,4D9CD@85008|Micromonosporales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS2_k127_5058654_0	66373.JOFQ01000003_gene5666	0.0	1171.0	COG0439@1|root,COG4770@1|root,COG4799@1|root,COG0439@2|Bacteria,COG4770@2|Bacteria,COG4799@2|Bacteria,2GIZP@201174|Actinobacteria	201174|Actinobacteria	I	carboxylase	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
TLS2_k127_5058654_19	1125973.JNLC01000012_gene1013	2.427e-21	110.0	COG1017@1|root,COG1017@2|Bacteria,1QVJP@1224|Proteobacteria,2U5M6@28211|Alphaproteobacteria,3JY65@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Belongs to the globin family	MA20_17055	-	1.14.12.17	ko:K05916	ko05132,map05132	-	-	-	ko00000,ko00001,ko01000	-	-	-	Globin
TLS2_k127_5058654_3	298655.KI912266_gene2210	5.953e-147	503.0	COG2909@1|root,COG2909@2|Bacteria,2GM03@201174|Actinobacteria,4ETTY@85013|Frankiales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_5058654_21	1229780.BN381_150027	3.116e-16	89.0	2DEPV@1|root,2ZNS5@2|Bacteria,2HEBP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5058654_4	1121861.KB899918_gene3259	1.56e-134	439.0	COG0520@1|root,COG0520@2|Bacteria,1MX5B@1224|Proteobacteria,2TVGK@28211|Alphaproteobacteria,2JQZW@204441|Rhodospirillales	204441|Rhodospirillales	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_5058654_14	1313172.YM304_08190	8.192e-67	242.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4CN3Q@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_5058654_11	351607.Acel_1448	5.117e-87	308.0	COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,2GIV9@201174|Actinobacteria,4EXEH@85013|Frankiales	201174|Actinobacteria	T	histidine kinase HAMP region domain protein	phoR	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_5058654_10	1246995.AFR_20565	7.272e-89	300.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4D94F@85008|Micromonosporales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	phoP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_5058654_15	105420.BBPO01000004_gene1404	2.199e-52	195.0	COG1544@1|root,COG1544@2|Bacteria,2IB6N@201174|Actinobacteria,2NJJS@228398|Streptacidiphilus	201174|Actinobacteria	J	Sigma 54 modulation/S30EA ribosomal protein C terminus	-	-	-	-	-	-	-	-	-	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
TLS2_k127_5058654_18	106370.Francci3_4502	7.387e-34	140.0	COG2905@1|root,COG2905@2|Bacteria,2GVP5@201174|Actinobacteria,4EWMQ@85013|Frankiales	201174|Actinobacteria	T	CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF1918
TLS2_k127_5058654_24	408672.NBCG_00751	2.342e-13	79.0	COG0778@1|root,COG0778@2|Bacteria,2I5BC@201174|Actinobacteria,4DSK6@85009|Propionibacteriales	201174|Actinobacteria	L	Domain of unknown function (DUF1918)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1918
TLS2_k127_5058654_8	479432.Sros_6203	3.541e-97	332.0	COG2378@1|root,COG2378@2|Bacteria,2GIZC@201174|Actinobacteria,4EG3V@85012|Streptosporangiales	201174|Actinobacteria	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
TLS2_k127_5058654_7	1313172.YM304_33320	6.225e-112	369.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4CMQN@84992|Acidimicrobiia	84992|Acidimicrobiia	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_5058654_1	525909.Afer_1569	0.0	1094.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4CMWW@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_5058654_13	1110502.TMO_1176	1.016e-67	234.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U5BM@28211|Alphaproteobacteria,2JS2Q@204441|Rhodospirillales	204441|Rhodospirillales	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_5058654_5	1123320.KB889738_gene5837	5.98e-132	437.0	COG3670@1|root,COG3670@2|Bacteria,2GK7D@201174|Actinobacteria	201174|Actinobacteria	Q	dioxygenase	-	-	-	ko:K11159	-	-	-	-	ko00000	-	-	-	RPE65
TLS2_k127_5058654_17	65497.JODV01000010_gene2585	4.667e-39	152.0	COG1309@1|root,COG1309@2|Bacteria,2IMN5@201174|Actinobacteria,4E40M@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TLS2_k127_5058654_27	1121272.KB903251_gene620	0.000149	53.0	COG3173@1|root,COG3173@2|Bacteria,2GJT0@201174|Actinobacteria,4D8QZ@85008|Micromonosporales	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_5058654_25	273677.BW34_01499	7.545e-09	59.0	COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria,4FNJ1@85023|Microbacteriaceae	201174|Actinobacteria	V	HNH nucleases	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222
TLS2_k127_5079025_7	1229780.BN381_130048	6.23e-23	107.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,3UWC5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	UvrD-like helicase C-terminal domain	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS2_k127_5079025_6	1282876.BAOK01000002_gene13	2.941e-28	121.0	COG1309@1|root,COG1309@2|Bacteria,1NF5P@1224|Proteobacteria	1224|Proteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
TLS2_k127_5079025_5	1237500.ANBA01000023_gene5018	1.051e-33	134.0	COG3467@1|root,COG3467@2|Bacteria,2IIAS@201174|Actinobacteria,4EKI3@85012|Streptosporangiales	201174|Actinobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx,Pyridox_ox_2
TLS2_k127_5079025_2	710111.FraQA3DRAFT_0792	9.14e-132	428.0	COG2141@1|root,COG2141@2|Bacteria,2GMUE@201174|Actinobacteria,4ET1B@85013|Frankiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_5079025_8	1120949.KB903295_gene2442	2.502e-09	64.0	2933D@1|root,2ZQKJ@2|Bacteria,2H0UQ@201174|Actinobacteria,4DK1Q@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5079025_10	479435.Kfla_6350	0.0007788	49.0	COG2334@1|root,COG2334@2|Bacteria,2IHHI@201174|Actinobacteria,4DTFV@85009|Propionibacteriales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_5079025_0	1313172.YM304_35250	2.629e-239	749.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2GM09@201174|Actinobacteria,4CMTF@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
TLS2_k127_5079025_3	1463885.KL578475_gene9717	3.144e-113	399.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GITZ@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TLS2_k127_5079025_1	525909.Afer_0459	7.738e-205	653.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4CNDM@84992|Acidimicrobiia	84992|Acidimicrobiia	F	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TLS2_k127_5079025_9	1174528.JH992898_gene4028	0.0001496	44.0	COG0076@1|root,COG0076@2|Bacteria,1GD62@1117|Cyanobacteria,1JME6@1189|Stigonemataceae	1117|Cyanobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
TLS2_k127_5090297_16	998674.ATTE01000001_gene3854	1.002e-44	183.0	COG2199@1|root,COG4191@1|root,COG3706@2|Bacteria,COG4191@2|Bacteria,1MZV7@1224|Proteobacteria,1S99U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
TLS2_k127_5090297_24	1123023.JIAI01000007_gene1719	2.641e-23	108.0	COG0748@1|root,COG0748@2|Bacteria,2IPWM@201174|Actinobacteria,4EC2P@85010|Pseudonocardiales	201174|Actinobacteria	P	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_5090297_0	1229780.BN381_130297	1.007e-206	659.0	COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome P450	cyp	-	1.14.15.14	ko:K20497	-	-	-	-	ko00000,ko00199,ko01000	-	-	-	p450
TLS2_k127_5090297_25	684949.ATTJ01000002_gene207	4.485e-21	103.0	COG1226@1|root,COG1226@2|Bacteria,1WNIC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Ion transport protein	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans
TLS2_k127_5090297_11	1306990.BARG01000052_gene6175	1.14e-54	201.0	COG3217@1|root,COG3217@2|Bacteria,2GND9@201174|Actinobacteria	201174|Actinobacteria	S	MOSC domain	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
TLS2_k127_5090297_23	1122182.KB903837_gene3803	1.878e-23	107.0	2DE8Y@1|root,2ZM0Q@2|Bacteria	2|Bacteria	S	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_5090297_13	512565.AMIS_54600	2.071e-51	189.0	COG3801@1|root,COG3801@2|Bacteria,2IQGZ@201174|Actinobacteria,4DFBY@85008|Micromonosporales	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
TLS2_k127_5090297_19	1211815.CBYP010000075_gene2952	1.153e-36	150.0	COG1295@1|root,COG1295@2|Bacteria	2|Bacteria	S	lipopolysaccharide transmembrane transporter activity	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_5090297_14	1380393.JHVP01000024_gene3309	8.057e-49	191.0	COG0392@1|root,COG0392@2|Bacteria,2ICMJ@201174|Actinobacteria,4ETKK@85013|Frankiales	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
TLS2_k127_5090297_6	1380393.JHVP01000005_gene3634	1.123e-60	236.0	COG0392@1|root,COG0392@2|Bacteria,2GMAV@201174|Actinobacteria,4EU4Q@85013|Frankiales	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
TLS2_k127_5090297_22	58123.JOFJ01000005_gene1300	6.005e-24	115.0	COG0392@1|root,COG0671@1|root,COG3642@1|root,COG0392@2|Bacteria,COG0671@2|Bacteria,COG3642@2|Bacteria,2GMAV@201174|Actinobacteria,4EHD3@85012|Streptosporangiales	201174|Actinobacteria	I	Lysylphosphatidylglycerol synthase TM region	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	LPG_synthase_TM,PAP2
TLS2_k127_5090297_4	1056816.JAFQ01000004_gene5567	4.003e-89	323.0	COG0392@1|root,COG0671@1|root,COG3642@1|root,COG0392@2|Bacteria,COG0671@2|Bacteria,COG3642@2|Bacteria,2GMAV@201174|Actinobacteria,4FXZC@85025|Nocardiaceae	201174|Actinobacteria	IT	Lysylphosphatidylglycerol synthase TM region	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	LPG_synthase_TM,PAP2
TLS2_k127_5090297_27	258533.BN977_03630	2.184e-19	104.0	COG2267@1|root,COG3710@1|root,COG2267@2|Bacteria,COG3710@2|Bacteria,2I419@201174|Actinobacteria,234R8@1762|Mycobacteriaceae	201174|Actinobacteria	IK	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Trans_reg_C
TLS2_k127_5090297_8	43759.JNWK01000056_gene1680	5.307e-59	232.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
TLS2_k127_5090297_7	1123024.AUII01000010_gene681	3.004e-60	228.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria,4EEKA@85010|Pseudonocardiales	201174|Actinobacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_5090297_31	1206733.BAGC01000041_gene2123	1.938e-10	66.0	COG1610@1|root,COG1610@2|Bacteria,2GQVP@201174|Actinobacteria,4G44H@85025|Nocardiaceae	201174|Actinobacteria	S	YqeY-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS2_k127_5090297_17	44454.NF84_06455	2.391e-44	164.0	COG0346@1|root,COG0346@2|Bacteria,2IKRF@201174|Actinobacteria,239B6@1762|Mycobacteriaceae	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_5090297_32	1123024.AUII01000008_gene1769	1.245e-06	60.0	2D0CU@1|root,32T8C@2|Bacteria,2GNI4@201174|Actinobacteria,4EC76@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5090297_3	1123024.AUII01000012_gene4221	2.031e-92	311.0	COG2513@1|root,COG2513@2|Bacteria,2GMQ4@201174|Actinobacteria,4E188@85010|Pseudonocardiales	201174|Actinobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
TLS2_k127_5090297_2	1211815.CBYP010000042_gene2406	6.454e-98	335.0	COG5285@1|root,COG5285@2|Bacteria,2GNXP@201174|Actinobacteria	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS2_k127_5090297_18	875328.JDM601_2174	1.631e-39	168.0	COG1024@1|root,COG1024@2|Bacteria,2H2U8@201174|Actinobacteria,23AUU@1762|Mycobacteriaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17,4.2.1.18	ko:K01692,ko:K13766	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00036,M00087	R02085,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115,RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_5090297_12	700508.D174_10620	1.478e-54	200.0	arCOG10154@1|root,3068I@2|Bacteria,2IKV1@201174|Actinobacteria,239BI@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5090297_15	1120950.KB892755_gene5928	1.316e-48	184.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_5090297_30	1379698.RBG1_1C00001G0249	8.637e-16	82.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_5090297_26	1445613.JALM01000005_gene1177	5.859e-21	101.0	COG3801@1|root,COG3801@2|Bacteria,2IQGZ@201174|Actinobacteria,4E52D@85010|Pseudonocardiales	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
TLS2_k127_5090297_9	1169161.KB897729_gene1343	6.167e-56	208.0	COG1576@1|root,COG3832@1|root,COG1576@2|Bacteria,COG3832@2|Bacteria,2I3MI@201174|Actinobacteria	201174|Actinobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,MDMPI_N
TLS2_k127_5090297_20	1120950.KB892801_gene1765	3.843e-31	134.0	COG0454@1|root,COG0456@2|Bacteria,2GQGN@201174|Actinobacteria,4DS9Y@85009|Propionibacteriales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_5090297_1	1304865.JAGF01000001_gene703	1.67e-99	341.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein	txlA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,SfLAP,Thioredoxin
TLS2_k127_5090297_28	512565.AMIS_25520	1.167e-18	98.0	COG1247@1|root,COG1247@2|Bacteria,2GR9D@201174|Actinobacteria,4DMPC@85008|Micromonosporales	201174|Actinobacteria	M	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_5090297_29	479435.Kfla_3855	3.704e-18	96.0	COG0561@1|root,COG0561@2|Bacteria,2IBMS@201174|Actinobacteria	201174|Actinobacteria	S	Sucrose-6F-phosphate phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
TLS2_k127_5090297_5	1229780.BN381_350135	3.965e-79	280.0	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,3UX9J@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	ko:K20469	-	-	-	-	ko00000,ko02000	2.A.86.1.7	-	-	AI-2E_transport
TLS2_k127_5090297_21	1123023.JIAI01000007_gene1824	1.321e-24	114.0	COG0346@1|root,COG0346@2|Bacteria,2IQB4@201174|Actinobacteria,4E5W6@85010|Pseudonocardiales	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_5090297_10	1229780.BN381_100026	1.978e-55	199.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,3UX0X@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DNA helicase	helD	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD-helicase,UvrD_C_2,Viral_helicase1
TLS2_k127_513688_6	479434.Sthe_0710	2.317e-30	136.0	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,2G7UT@200795|Chloroflexi,27Y1B@189775|Thermomicrobia	189775|Thermomicrobia	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3
TLS2_k127_513688_4	1463936.JOJI01000058_gene6134	1.953e-71	271.0	COG3899@1|root,COG3903@1|root,COG3899@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
TLS2_k127_513688_3	471852.Tcur_0550	3.159e-101	342.0	COG2227@1|root,COG2227@2|Bacteria,2I3C3@201174|Actinobacteria,4ER5A@85012|Streptosporangiales	201174|Actinobacteria	H	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_513688_0	1313172.YM304_15200	1.98e-166	532.0	COG0076@1|root,COG0076@2|Bacteria,2GKIH@201174|Actinobacteria,4CN9Y@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.15,4.1.2.27	ko:K01580,ko:K01634	ko00250,ko00410,ko00430,ko00600,ko00650,ko01100,ko01110,ko01120,ko02024,ko04071,ko04727,ko04940,map00250,map00410,map00430,map00600,map00650,map01100,map01110,map01120,map02024,map04071,map04727,map04940	M00027,M00100	R00261,R00489,R01682,R02464,R02466,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
TLS2_k127_513688_8	477641.MODMU_5443	1.214e-07	60.0	COG2230@1|root,COG2230@2|Bacteria,2IHZD@201174|Actinobacteria,4ESSZ@85013|Frankiales	201174|Actinobacteria	M	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS2_k127_513688_2	1255043.TVNIR_1678	1.364e-138	459.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WZYR@135613|Chromatiales	135613|Chromatiales	U	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
TLS2_k127_513688_7	69042.WH5701_04545	6.33e-19	96.0	COG0288@1|root,COG0288@2|Bacteria,1G3RZ@1117|Cyanobacteria,1GZ8U@1129|Synechococcus	1117|Cyanobacteria	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS2_k127_513688_5	263358.VAB18032_13490	4.072e-58	208.0	COG0607@1|root,COG0607@2|Bacteria,2IB6H@201174|Actinobacteria,4D9CF@85008|Micromonosporales	201174|Actinobacteria	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892,Rhodanese
TLS2_k127_513688_1	350054.Mflv_0985	1.13e-147	474.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,236XH@1762|Mycobacteriaceae	201174|Actinobacteria	P	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
TLS2_k127_5161063_3	105420.BBPO01000006_gene3016	3.578e-06	49.0	COG0748@1|root,COG0748@2|Bacteria,2IFYD@201174|Actinobacteria,2NIPG@228398|Streptacidiphilus	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS2_k127_5161063_1	1283283.ATXA01000019_gene2908	1.266e-116	381.0	COG2267@1|root,COG2267@2|Bacteria,2HM71@201174|Actinobacteria	201174|Actinobacteria	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_5161063_2	378806.STAUR_2214	2.782e-39	152.0	COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria,1MWIC@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	MA20_27725	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,MarR_2
TLS2_k127_5161063_0	1125971.ASJB01000069_gene474	3.855e-123	402.0	COG4188@1|root,COG4188@2|Bacteria,2H3T8@201174|Actinobacteria,4EFDW@85010|Pseudonocardiales	201174|Actinobacteria	S	dienelactone hydrolase	-	-	3.1.1.101	ko:K21104	-	-	R11540	-	ko00000,ko01000	-	-	-	Abhydrolase_5,Chlorophyllase2,DLH,Hydrolase_4,PAF-AH_p_II
TLS2_k127_5223207_4	397291.C804_02113	4.425e-11	67.0	COG3393@1|root,COG3393@2|Bacteria,1TRN7@1239|Firmicutes,24A2B@186801|Clostridia,27K0A@186928|unclassified Lachnospiraceae	186801|Clostridia	S	GNAT acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,GNAT_acetyltran
TLS2_k127_5223207_3	675635.Psed_0674	8.499e-45	178.0	COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,2I2RA@201174|Actinobacteria,4E9MN@85010|Pseudonocardiales	201174|Actinobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF
TLS2_k127_5223207_1	1120971.AUCA01000032_gene3024	7.6e-108	365.0	COG3007@1|root,COG3007@2|Bacteria,1TWIF@1239|Firmicutes,4HCSV@91061|Bacilli	91061|Bacilli	I	Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA)	fabV	-	1.3.1.44,1.3.1.9	ko:K00209	ko00061,ko00650,ko01100,ko01120,ko01200,ko01212,map00061,map00650,map01100,map01120,map01200,map01212	M00083	R01171,R04429,R04724,R04955,R04958,R04961,R04966,R04969	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Eno-Rase_FAD_bd,Eno-Rase_NADH_b,Enoyl_reductase
TLS2_k127_5223207_0	1121924.ATWH01000020_gene3267	1.622e-124	404.0	COG0596@1|root,COG0596@2|Bacteria,2GKT5@201174|Actinobacteria,4FS78@85023|Microbacteriaceae	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_52316_0	1229780.BN381_80295	6.695e-147	477.0	COG0208@1|root,COG0208@2|Bacteria,2GJKZ@201174|Actinobacteria	201174|Actinobacteria	F	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
TLS2_k127_52316_7	1323361.JPOC01000048_gene386	9.941e-19	99.0	COG2852@1|root,COG2852@2|Bacteria,2GKCY@201174|Actinobacteria,4FXXU@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_1,AbiEi_4,DUF559
TLS2_k127_52316_5	67373.JOBF01000003_gene480	5.117e-22	106.0	COG0778@1|root,COG0778@2|Bacteria,2IPN9@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_52316_6	1298863.AUEP01000011_gene609	4.498e-21	98.0	COG3153@1|root,COG3153@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_9
TLS2_k127_52316_4	469383.Cwoe_0338	3.012e-52	186.0	COG0545@1|root,COG0545@2|Bacteria,2IHQC@201174|Actinobacteria,4CQ31@84995|Rubrobacteria	84995|Rubrobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
TLS2_k127_52316_2	1313172.YM304_10150	3.466e-66	248.0	COG0477@1|root,COG2814@2|Bacteria,2I8HS@201174|Actinobacteria	201174|Actinobacteria	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
TLS2_k127_52316_1	1089552.KI911559_gene373	4.318e-128	417.0	COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria,2JPGW@204441|Rhodospirillales	204441|Rhodospirillales	G	COG0524 Sugar kinases, ribokinase family	pfkB	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS2_k127_52316_3	1229780.BN381_250091	1.8e-65	232.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,3UWD9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	ERAP1-like C-terminal domain	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
TLS2_k127_5305920_5	1313172.YM304_18300	5.469e-101	348.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,4CN55@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	-	-	ko:K03545	-	-	-	-	ko00000	-	-	-	Trigger_C,Trigger_N
TLS2_k127_5305920_8	1121877.JQKF01000001_gene1378	1.267e-73	255.0	COG0740@1|root,COG0740@2|Bacteria,2GKNK@201174|Actinobacteria,4CMUY@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TLS2_k127_5305920_1	1032480.MLP_36550	2.373e-195	618.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,4DP0T@85009|Propionibacteriales	201174|Actinobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
TLS2_k127_5305920_4	1313172.YM304_18330	2.013e-112	378.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4CNAR@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Mur ligase middle domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
TLS2_k127_5305920_9	1229780.BN381_80093	2.434e-55	202.0	COG0105@1|root,COG0105@2|Bacteria,2IFBU@201174|Actinobacteria,3UWSN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Nucleoside diphosphate kinase	ndk	GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	iNJ661.Rv2445c	NDK
TLS2_k127_5305920_2	1229780.BN381_80095	3.603e-162	517.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,3UX41@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Cell division protein FtsA	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TLS2_k127_5305920_11	1343740.M271_32205	1.232e-25	117.0	COG1792@1|root,COG1792@2|Bacteria,2GJN0@201174|Actinobacteria	201174|Actinobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
TLS2_k127_5305920_13	1229780.BN381_80097	9.634e-13	76.0	COG2891@1|root,COG2891@2|Bacteria	2|Bacteria	M	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins	mreD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
TLS2_k127_5305920_3	1229780.BN381_80098	7.549e-124	421.0	COG0768@1|root,COG0768@2|Bacteria,2GJ61@201174|Actinobacteria,3UXBI@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Penicillin-binding Protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	FTSW_RODA_SPOVE,PBP_dimer,Transpeptidase
TLS2_k127_5305920_6	1121877.JQKF01000002_gene1765	9.149e-81	288.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4CN2U@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell cycle protein	-	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
TLS2_k127_5305920_12	561175.KB894094_gene1573	7.16e-14	81.0	COG3170@1|root,COG3170@2|Bacteria,2GWTF@201174|Actinobacteria	201174|Actinobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5305920_7	710685.MycrhN_5522	2.135e-74	252.0	COG3832@1|root,COG3832@2|Bacteria,2IHQ1@201174|Actinobacteria,238XQ@1762|Mycobacteriaceae	201174|Actinobacteria	S	polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_5305920_10	1123023.JIAI01000005_gene672	9.339e-32	134.0	COG0500@1|root,COG2226@2|Bacteria,2I1M7@201174|Actinobacteria,4E7IF@85010|Pseudonocardiales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_5305920_0	1313172.YM304_18420	3.536e-203	641.0	COG1032@1|root,COG1032@2|Bacteria,2GJY1@201174|Actinobacteria	201174|Actinobacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_5336591_8	1304865.JAGF01000001_gene2453	1.006e-55	207.0	COG1073@1|root,COG1073@2|Bacteria,2IBIZ@201174|Actinobacteria	201174|Actinobacteria	L	photosystem II stabilization	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3
TLS2_k127_5336591_4	471852.Tcur_3717	2.734e-94	325.0	COG3186@1|root,COG3186@2|Bacteria,2GKCB@201174|Actinobacteria,4EIH7@85012|Streptosporangiales	201174|Actinobacteria	E	Biopterin-dependent aromatic amino acid hydroxylase	phhA	-	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
TLS2_k127_5336591_1	1382359.JIAL01000001_gene2353	1.346e-121	408.0	COG3185@1|root,COG3185@2|Bacteria,3Y2ST@57723|Acidobacteria,2JISR@204432|Acidobacteriia	204432|Acidobacteriia	E	Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal	-	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase
TLS2_k127_5336591_3	1449069.JMLO01000005_gene1533	2.338e-100	344.0	COG0179@1|root,COG0179@2|Bacteria,2GNGC@201174|Actinobacteria,4FVD9@85025|Nocardiaceae	201174|Actinobacteria	Q	Fumarylacetoacetase N-terminal	fahA	-	3.7.1.2	ko:K01555	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FAA_hydrolase,FAA_hydrolase_N
TLS2_k127_5336591_0	479432.Sros_8845	4.398e-132	442.0	COG3508@1|root,COG3508@2|Bacteria,2GKZV@201174|Actinobacteria,4EHDH@85012|Streptosporangiales	201174|Actinobacteria	Q	homogentisate 1,2-dioxygenase	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
TLS2_k127_5336591_2	1056816.JAFQ01000004_gene315	5.017e-113	368.0	COG0262@1|root,COG0262@2|Bacteria,2GYU7@201174|Actinobacteria,4G0RJ@85025|Nocardiaceae	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_5336591_12	1449044.JMLE01000001_gene3703	1.007e-44	177.0	COG3593@1|root,COG3593@2|Bacteria,2GMN5@201174|Actinobacteria,1WC29@1268|Micrococcaceae	201174|Actinobacteria	L	DNA synthesis involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5336591_7	1120950.KB892796_gene2274	1.32e-72	258.0	2DB9K@1|root,2Z7XA@2|Bacteria,2IB4R@201174|Actinobacteria	201174|Actinobacteria	S	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS2_k127_5336591_18	29306.JOBE01000016_gene1356	8.071e-06	55.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	2.4.1.187	ko:K04749,ko:K05946,ko:K06378	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003,ko03021	-	GT26	-	Glyco_tran_WecB,STAS,STAS_2
TLS2_k127_5336591_11	469383.Cwoe_3147	1.963e-49	188.0	COG2203@1|root,COG2203@2|Bacteria,2IQAM@201174|Actinobacteria	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS2_k127_5336591_6	1121877.JQKF01000048_gene761	2.54e-75	263.0	COG2203@1|root,COG2203@2|Bacteria,2GQ2V@201174|Actinobacteria,4CNWF@84992|Acidimicrobiia	84992|Acidimicrobiia	K	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS2_k127_5336591_15	1453503.AU05_21485	1.958e-34	137.0	2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,1SA77@1236|Gammaproteobacteria,1YGFT@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
TLS2_k127_5336591_13	1313172.YM304_06300	4.913e-44	164.0	COG1633@1|root,COG1633@2|Bacteria,2IHZY@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF2383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2383
TLS2_k127_5336591_9	1173022.Cri9333_4024	1.613e-54	193.0	COG4288@1|root,COG4288@2|Bacteria,1G65D@1117|Cyanobacteria,1HBXT@1150|Oscillatoriales	1117|Cyanobacteria	S	Anabaena sensory rhodopsin transducer	-	-	-	-	-	-	-	-	-	-	-	-	ASRT
TLS2_k127_5336591_19	1157634.KB912956_gene1937	2.216e-05	53.0	COG0645@1|root,COG0645@2|Bacteria,2I4UW@201174|Actinobacteria	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18,AAA_33,CPT
TLS2_k127_5336591_5	698757.Pogu_2670	3.12e-77	270.0	COG1064@1|root,arCOG01455@2157|Archaea	2157|Archaea	C	alcohol dehydrogenase	-	-	1.1.1.1,1.1.1.2	ko:K00002,ko:K13953	ko00010,ko00040,ko00071,ko00350,ko00561,ko00625,ko00626,ko00830,ko00930,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00071,map00350,map00561,map00625,map00626,map00830,map00930,map00980,map00982,map01100,map01110,map01120,map01130,map01220	M00014	R00623,R00746,R00754,R01041,R01481,R02124,R04880,R05231,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00108,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_5336591_14	1246995.AFR_17070	3.12e-37	151.0	COG0640@1|root,COG0640@2|Bacteria,2IQ55@201174|Actinobacteria,4DET1@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_5336591_10	55952.BU52_00060	7.45e-53	210.0	COG3832@1|root,COG3832@2|Bacteria,2I8ND@201174|Actinobacteria	201174|Actinobacteria	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_5336591_16	595536.ADVE02000001_gene1755	1.72e-13	70.0	28HGI@1|root,2Z7SC@2|Bacteria,1MWKC@1224|Proteobacteria,2TUQY@28211|Alphaproteobacteria,36ZBU@31993|Methylocystaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5401240_8	365528.KB891218_gene1507	3.861e-53	191.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4ES0C@85013|Frankiales	201174|Actinobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_5401240_2	1229780.BN381_50140	3.202e-163	526.0	COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,3UWBY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS2_k127_5401240_4	1229780.BN381_50141	9.08e-144	484.0	COG0505@1|root,COG0505@2|Bacteria,2GKFA@201174|Actinobacteria,3UWBX@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1383	CPSase_sm_chain,GATase
TLS2_k127_5401240_0	1229780.BN381_50144	0.0	1630.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,3UW8D@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS2_k127_5401240_6	1313172.YM304_20470	7.284e-99	332.0	COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4CN0R@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TLS2_k127_5401240_7	1229780.BN381_50146	5.333e-62	222.0	COG0284@1|root,COG0284@2|Bacteria,2HPEA@201174|Actinobacteria,3UXRN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
TLS2_k127_5401240_11	1121877.JQKF01000023_gene2253	3.318e-31	130.0	COG0099@1|root,COG0099@2|Bacteria,2IKPU@201174|Actinobacteria,4CN68@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Helix-hairpin-helix DNA-binding motif class 1	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5401240_9	1313172.YM304_20490	3.498e-47	175.0	COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria,4CN5V@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Guanylate kinase homologues.	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
TLS2_k127_5401240_10	862751.SACTE_3801	6.721e-38	151.0	COG2318@1|root,COG2318@2|Bacteria,2I1DJ@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
TLS2_k127_5401240_12	1229780.BN381_50148	2.033e-23	106.0	COG1758@1|root,COG1758@2|Bacteria,2IQHU@201174|Actinobacteria,3UWXS@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
TLS2_k127_5401240_3	1313172.YM304_20510	2.061e-151	491.0	COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria,4CMYE@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TLS2_k127_5401240_1	1430331.EP10_09910	4.27e-164	532.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,4HB33@91061|Bacilli,1WF8Q@129337|Geobacillus	91061|Bacilli	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
TLS2_k127_5401240_5	1229780.BN381_50152	3.54e-143	473.0	COG1198@1|root,COG1198@2|Bacteria,2GKES@201174|Actinobacteria,3UWAF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
TLS2_k127_5401240_13	1120949.KB903356_gene8642	6.058e-06	51.0	COG2306@1|root,COG2306@2|Bacteria,2GJP9@201174|Actinobacteria,4DCVC@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF402)	-	-	-	-	-	-	-	-	-	-	-	-	DUF402
TLS2_k127_5431004_2	390989.JOEG01000011_gene399	1.022e-53	203.0	COG2764@1|root,COG3324@1|root,COG2764@2|Bacteria,COG3324@2|Bacteria,2IG41@201174|Actinobacteria,4DDVX@85008|Micromonosporales	201174|Actinobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_5431004_3	1206743.BAGM01000004_gene4370	9.465e-49	185.0	COG1595@1|root,COG1595@2|Bacteria,2II44@201174|Actinobacteria,4G8T9@85025|Nocardiaceae	201174|Actinobacteria	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_5431004_4	443218.AS9A_2001	9.172e-32	137.0	2DP3D@1|root,330CN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5431004_1	1313172.YM304_34380	6.077e-71	248.0	COG0266@1|root,COG0266@2|Bacteria,2GKCW@201174|Actinobacteria	201174|Actinobacteria	L	Glycosylase	nei	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_5431004_0	561175.KB894096_gene526	1.245e-113	370.0	COG0447@1|root,COG0447@2|Bacteria,2GK5G@201174|Actinobacteria,4EI6I@85012|Streptosporangiales	201174|Actinobacteria	H	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)	menB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016043,GO:0016829,GO:0016830,GO:0016833,GO:0022607,GO:0034214,GO:0042180,GO:0042181,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576,GO:1901661,GO:1901663	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_5434359_2	1906.SFRA_32250	4.411e-101	349.0	COG1741@1|root,COG1741@2|Bacteria,2GM9P@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
TLS2_k127_5434359_4	543632.JOJL01000022_gene865	1.637e-22	105.0	COG0526@1|root,COG0526@2|Bacteria,2IR6C@201174|Actinobacteria,4DF6H@85008|Micromonosporales	201174|Actinobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_5434359_1	1229780.BN381_640027	4.399e-122	408.0	COG1092@1|root,COG1092@2|Bacteria,2GXDD@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TLS2_k127_5434359_0	1229780.BN381_290113	1.845e-166	534.0	COG2239@1|root,COG2239@2|Bacteria,2GMMK@201174|Actinobacteria,3UWK7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	MgtE intracellular N domain	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N,PRC
TLS2_k127_5434359_3	1122939.ATUD01000006_gene1788	1.883e-65	233.0	COG0431@1|root,COG0431@2|Bacteria,2GNFR@201174|Actinobacteria,4CSQA@84995|Rubrobacteria	84995|Rubrobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS2_k127_5434359_5	1122609.AUGT01000029_gene2619	4.52e-13	79.0	COG2856@1|root,COG2856@2|Bacteria,2GPBB@201174|Actinobacteria,4DTVM@85009|Propionibacteriales	201174|Actinobacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5509363_11	1205910.B005_2824	0.0005155	46.0	COG1366@1|root,COG1366@2|Bacteria,2H01H@201174|Actinobacteria	201174|Actinobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
TLS2_k127_5509363_3	1229780.BN381_140046	1.686e-154	506.0	COG0322@1|root,COG2176@1|root,COG0322@2|Bacteria,COG2176@2|Bacteria,2GMC0@201174|Actinobacteria,3UWMB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	GIY-YIG type nucleases (URI domain)	dnaQ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
TLS2_k127_5509363_6	1415754.JQMK01000002_gene2239	1.242e-34	136.0	COG2329@1|root,COG2329@2|Bacteria,1N062@1224|Proteobacteria,1SABZ@1236|Gammaproteobacteria,46880@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	enzyme involved in biosynthesis of extracellular polysaccharides	yqjZ	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS2_k127_5509363_4	1229780.BN381_500001	9.238e-102	346.0	COG0547@1|root,COG0547@2|Bacteria,2GM4G@201174|Actinobacteria,3UWGV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TLS2_k127_5509363_8	1313172.YM304_19060	1.743e-19	98.0	2CC1Y@1|root,32YV9@2|Bacteria	2|Bacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	-	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS2_k127_5509363_5	1068980.ARVW01000001_gene5494	2.687e-44	179.0	COG1211@1|root,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,4E6T4@85010|Pseudonocardiales	201174|Actinobacteria	I	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	ispD	-	1.1.1.405,2.7.7.40,2.7.7.60	ko:K00991,ko:K21681	ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130	M00096	R01525,R02921,R05633	RC00002,RC00089	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
TLS2_k127_5509363_0	1229780.BN381_170034	5.876e-183	588.0	COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,3UWFB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TLS2_k127_5509363_2	1229780.BN381_170035	3.675e-158	518.0	COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria	201174|Actinobacteria	C	FAD linked	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_5509363_1	1229780.BN381_170037	3.382e-161	524.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,3UWF2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	-	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS2_k127_5509363_10	208444.JNYY01000011_gene3016	3.827e-13	81.0	COG3794@1|root,COG3794@2|Bacteria,2H73G@201174|Actinobacteria,4E2Z7@85010|Pseudonocardiales	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
TLS2_k127_5509363_7	345341.KUTG_04140	1.72e-29	120.0	2DTR4@1|root,33MCB@2|Bacteria,2HAJT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5509363_9	298655.KI912266_gene6084	2.646e-19	99.0	COG5401@1|root,COG5401@2|Bacteria,2H4HT@201174|Actinobacteria	201174|Actinobacteria	S	Immunoglobulin-like domain of bacterial spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
TLS2_k127_5587551_26	1123023.JIAI01000012_gene9197	6.358e-26	112.0	COG2890@1|root,COG2890@2|Bacteria,2HQ7T@201174|Actinobacteria,4E8YZ@85010|Pseudonocardiales	201174|Actinobacteria	J	Methylase of polypeptide chain release	-	-	-	-	-	-	-	-	-	-	-	-	MTS
TLS2_k127_5587551_21	1133849.O3I_026330	3.603e-40	169.0	COG0642@1|root,COG2931@1|root,COG2205@2|Bacteria,COG2931@2|Bacteria,2I2QY@201174|Actinobacteria,4FZ0G@85025|Nocardiaceae	201174|Actinobacteria	T	Domain of unknown function (DUF4173)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4173,HAMP,HATPase_c,HisKA
TLS2_k127_5587551_14	479432.Sros_1550	7.519e-79	286.0	COG0810@1|root,COG5002@1|root,COG0810@2|Bacteria,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4EHI2@85012|Streptosporangiales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_5587551_13	1120934.KB894404_gene659	4.846e-84	301.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,4DX7M@85010|Pseudonocardiales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	cseB	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_5587551_8	234621.RER_17880	8.254e-129	420.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4FUJH@85025|Nocardiaceae	201174|Actinobacteria	V	ABC transporter ATP-binding	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_5587551_6	1304865.JAGF01000001_gene1800	7.828e-150	505.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4F1PH@85016|Cellulomonadaceae	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_5587551_23	1210884.HG799477_gene15476	1.471e-34	139.0	COG0454@1|root,COG0456@2|Bacteria,2J2NE@203682|Planctomycetes	203682|Planctomycetes	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.57	ko:K22441	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
TLS2_k127_5587551_22	400668.Mmwyl1_3008	1.768e-35	142.0	COG1011@1|root,COG1011@2|Bacteria,1QSY2@1224|Proteobacteria,1RWK3@1236|Gammaproteobacteria,1XM90@135619|Oceanospirillales	135619|Oceanospirillales	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	3.1.3.10	ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_5587551_0	1229780.BN381_410025	0.0	1152.0	COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria	201174|Actinobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
TLS2_k127_5587551_20	345341.KUTG_02612	6.649e-41	157.0	COG1733@1|root,COG1733@2|Bacteria,2GMQG@201174|Actinobacteria,4E3G4@85010|Pseudonocardiales	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS2_k127_5587551_17	1229780.BN381_90077	2.302e-54	209.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS2_k127_5587551_15	1313172.YM304_10870	5.221e-67	248.0	COG0671@1|root,COG0671@2|Bacteria,2GMYU@201174|Actinobacteria	201174|Actinobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
TLS2_k127_5587551_1	1229780.BN381_90078	3.715e-246	775.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,3UW82@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
TLS2_k127_5587551_10	105420.BBPO01000011_gene1963	9.048e-97	334.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,2NHNG@228398|Streptacidiphilus	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_5587551_18	1089544.KB912942_gene1686	8.667e-51	194.0	COG0842@1|root,COG0842@2|Bacteria,2H2PR@201174|Actinobacteria	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_5587551_16	1229780.BN381_130173	3.449e-65	231.0	COG0694@1|root,COG0694@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	nfuA	-	-	ko:K07400	-	-	-	-	ko00000	-	-	-	Nfu_N,NifU
TLS2_k127_5587551_12	883078.HMPREF9695_01831	2.296e-87	300.0	COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,2TVBC@28211|Alphaproteobacteria,3JSPF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_5587551_7	1333998.M2A_2226	8.459e-139	458.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2TRD1@28211|Alphaproteobacteria,4BRR5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	MBOAT, membrane-bound O-acyltransferase family	algI	-	-	-	-	-	-	-	-	-	-	-	MBOAT
TLS2_k127_5587551_19	298653.Franean1_0817	1.336e-42	170.0	COG2845@1|root,COG2845@2|Bacteria,2GU62@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF459)	-	-	-	ko:K09795	-	-	-	-	ko00000	-	-	-	DUF459
TLS2_k127_5587551_4	1229780.BN381_430008	4.883e-177	565.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_5587551_28	716544.wcw_1318	1.058e-11	75.0	COG1320@1|root,COG1320@2|Bacteria,2JHG8@204428|Chlamydiae	204428|Chlamydiae	P	Multisubunit Na H antiporter, MnhG subunit	mrpG	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
TLS2_k127_5587551_29	644283.Micau_2664	1.601e-06	59.0	COG2212@1|root,COG2212@2|Bacteria,2GRIE@201174|Actinobacteria,4DFXD@85008|Micromonosporales	201174|Actinobacteria	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	mrpF	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
TLS2_k127_5587551_27	1120948.KB903217_gene1449	3.484e-24	111.0	COG1863@1|root,COG1863@2|Bacteria,2IQD6@201174|Actinobacteria,4E5KJ@85010|Pseudonocardiales	201174|Actinobacteria	P	Multisubunit Na H antiporter, MnhE subunit	mrpE	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
TLS2_k127_5587551_5	1229780.BN381_150134	3.185e-155	505.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria,3UX2B@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	CP	Proton-conducting membrane transporter	mrpD	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
TLS2_k127_5587551_24	1313172.YM304_38090	9.323e-33	139.0	COG1006@1|root,COG1006@2|Bacteria,2ISBC@201174|Actinobacteria	201174|Actinobacteria	P	Multisubunit Na H antiporter MnhC subunit	mrpC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
TLS2_k127_5587551_25	1380354.JIAN01000005_gene2119	1.476e-32	134.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,2GIT4@201174|Actinobacteria,4F1UH@85016|Cellulomonadaceae	201174|Actinobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	mrpA/mrpB	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
TLS2_k127_5587551_2	1380356.JNIK01000011_gene1950	2.635e-200	652.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,2GIT4@201174|Actinobacteria,4ERUP@85013|Frankiales	201174|Actinobacteria	CP	Na H antiporter	mrpA/mrpB	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
TLS2_k127_5587551_3	1229780.BN381_90087	1.059e-186	616.0	COG0488@1|root,COG0488@2|Bacteria,2GJ5M@201174|Actinobacteria,3UWE3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	yjjK	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
TLS2_k127_5587551_11	656024.FsymDg_2567	1.113e-89	324.0	COG0613@1|root,COG0613@2|Bacteria,2GIZ5@201174|Actinobacteria,4ERIA@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3097)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3097
TLS2_k127_5587551_9	66869.JNXG01000001_gene3618	4.367e-108	370.0	COG0596@1|root,COG0596@2|Bacteria,2GJYS@201174|Actinobacteria,4192Y@629295|Streptomyces griseus group	201174|Actinobacteria	S	TAP-like protein	slpD	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS2_k127_5627152_9	1229780.BN381_40079	2.872e-88	299.0	COG2135@1|root,COG2135@2|Bacteria,2GKY8@201174|Actinobacteria,3UWQB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	SOS response associated peptidase (SRAP)	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
TLS2_k127_5627152_4	1122611.KB903985_gene3663	6.617e-165	535.0	COG2070@1|root,COG2070@2|Bacteria,2I93H@201174|Actinobacteria,4EIEF@85012|Streptosporangiales	201174|Actinobacteria	S	2-Nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
TLS2_k127_5627152_17	525909.Afer_1452	5.881e-28	118.0	COG1959@1|root,COG1959@2|Bacteria,2GS0E@201174|Actinobacteria,4CNRF@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TLS2_k127_5627152_6	590998.Celf_1184	7.086e-148	478.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria	201174|Actinobacteria	C	Radical SAM	pqqE	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
TLS2_k127_5627152_7	1229780.BN381_130182	1.444e-113	382.0	COG1232@1|root,COG1232@2|Bacteria,2GMMA@201174|Actinobacteria,3UXBD@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemG	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS2_k127_5627152_10	1229780.BN381_40073	3.58e-81	287.0	COG2208@1|root,COG2208@2|Bacteria,2IHH3@201174|Actinobacteria	201174|Actinobacteria	KT	stage II sporulation	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
TLS2_k127_5627152_3	1229780.BN381_40072	3.671e-190	620.0	COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria,3UWEY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	Cytidylate_kin,KH_dom-like,MMR_HSR1
TLS2_k127_5627152_2	1313172.YM304_25530	6.913e-196	623.0	COG1625@1|root,COG1625@2|Bacteria,2H3RR@201174|Actinobacteria,4CMW9@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Protein of unknown function (DUF512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
TLS2_k127_5627152_5	1313172.YM304_25520	4.472e-160	510.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4CMP7@84992|Acidimicrobiia	84992|Acidimicrobiia	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
TLS2_k127_5627152_19	1007104.SUS17_958	1.367e-07	62.0	COG1846@1|root,COG1846@2|Bacteria,1N4C0@1224|Proteobacteria,2UE5V@28211|Alphaproteobacteria,2K5X5@204457|Sphingomonadales	204457|Sphingomonadales	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_5627152_0	106370.Francci3_1034	0.0	1189.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4ES40@85013|Frankiales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_5627152_16	1089544.KB912942_gene1790	5.247e-33	132.0	2E8WU@1|root,3336Z@2|Bacteria,2GR5V@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5627152_13	502025.Hoch_1760	6.808e-61	223.0	COG4341@1|root,COG4341@2|Bacteria,1QHQD@1224|Proteobacteria	1224|Proteobacteria	S	Phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
TLS2_k127_5627152_11	1211815.CBYP010000029_gene1234	5.01e-67	243.0	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,4ESP8@85013|Frankiales	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K20469	-	-	-	-	ko00000,ko02000	2.A.86.1.7	-	-	AI-2E_transport
TLS2_k127_5627152_1	1229780.BN381_450030	7.591e-244	767.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,3UW8G@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS2_k127_5627152_14	1313172.YM304_20160	7.049e-50	189.0	COG0204@1|root,COG0204@2|Bacteria,2HG51@201174|Actinobacteria,4CN6X@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_5627152_12	1313172.YM304_20150	3.118e-65	229.0	COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,4CNDQ@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Cytidylate kinase	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
TLS2_k127_5627152_8	649831.L083_2002	3.168e-96	321.0	COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria,4DB3A@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TLS2_k127_5627252_2	1265310.CCBD010000015_gene3703	4.412e-141	460.0	COG0183@1|root,COG0183@2|Bacteria,2GKH4@201174|Actinobacteria,237UH@1762|Mycobacteriaceae	201174|Actinobacteria	I	Acetyl-CoA acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C
TLS2_k127_5627252_12	1078020.KEK_09202	2.727e-27	116.0	COG1545@1|root,COG1545@2|Bacteria,2II25@201174|Actinobacteria,235WU@1762|Mycobacteriaceae	201174|Actinobacteria	S	Nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
TLS2_k127_5627252_1	402881.Plav_0570	2.259e-173	560.0	COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,2U3CV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_5627252_3	1068980.ARVW01000001_gene5853	1.979e-113	373.0	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,4E15A@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	GO:0003674,GO:0003824,GO:0004303,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006066,GO:0006629,GO:0007568,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0014070,GO:0016125,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0018812,GO:0030283,GO:0032502,GO:0033764,GO:0033993,GO:0042221,GO:0042493,GO:0042579,GO:0042802,GO:0042803,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044594,GO:0046983,GO:0048545,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071310,GO:0071407,GO:0071704,GO:1901360,GO:1901615,GO:1902652	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_5627252_8	1229780.BN381_10244	8.044e-69	258.0	2FACV@1|root,342M7@2|Bacteria,2H6AW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5627252_6	710111.FraQA3DRAFT_1003	9.125e-82	285.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4ERI1@85013|Frankiales	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_5627252_5	656024.FsymDg_0787	2.507e-98	326.0	COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,4ESDQ@85013|Frankiales	201174|Actinobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS2_k127_5627252_11	1229780.BN381_90069	4.439e-51	197.0	COG1876@1|root,COG1876@2|Bacteria,2IQI8@201174|Actinobacteria	201174|Actinobacteria	M	peptidase M15B and M15C DD-carboxypeptidase VanY endolysin	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	B_lectin,VanY
TLS2_k127_5627252_4	1123501.KB902280_gene425	1.66e-109	367.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2TRN4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glycine cleavage system T protein	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TLS2_k127_5627252_0	1122611.KB903939_gene400	0.0	1210.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria,4EI8D@85012|Streptosporangiales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
TLS2_k127_5627252_9	1123228.AUIH01000032_gene1719	6.57e-68	246.0	COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,1RQ1V@1236|Gammaproteobacteria,1XHC2@135619|Oceanospirillales	135619|Oceanospirillales	F	Belongs to the IUNH family	-	-	-	-	-	-	-	-	-	-	-	-	IU_nuc_hydro
TLS2_k127_5627252_13	596328.HMPREF0578_2008	1.476e-13	73.0	2C7XW@1|root,32RR4@2|Bacteria,2IQ5R@201174|Actinobacteria,4D62M@85005|Actinomycetales	201174|Actinobacteria	S	Protein of unknown function (DUF3499)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3499
TLS2_k127_5627252_14	580340.Tlie_1652	2.422e-12	79.0	COG1331@1|root,COG1331@2|Bacteria	2|Bacteria	O	Highly conserved protein containing a thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4861,Glyco_hydro_76
TLS2_k127_5627252_15	448385.sce1927	5.518e-12	72.0	2E6S9@1|root,331CB@2|Bacteria,1QQT9@1224|Proteobacteria,43E0N@68525|delta/epsilon subdivisions,2X94D@28221|Deltaproteobacteria,2Z1UU@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5627252_10	448385.sce1926	1.478e-63	246.0	2B8GZ@1|root,321S2@2|Bacteria,1PMCZ@1224|Proteobacteria,439VN@68525|delta/epsilon subdivisions,2X59R@28221|Deltaproteobacteria,2Z0AZ@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VKG_Carbox
TLS2_k127_5627252_7	1229780.BN381_430028	1.105e-73	256.0	COG0686@1|root,COG0686@2|Bacteria,2GJ6G@201174|Actinobacteria,3UWER@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TLS2_k127_5646602_6	1229780.BN381_80180	2.617e-83	284.0	COG0389@1|root,COG0389@2|Bacteria,2GMZ3@201174|Actinobacteria,3UWGC@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	impB/mucB/samB family	dinB_2	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
TLS2_k127_5646602_3	1313172.YM304_06500	1.692e-127	415.0	COG2141@1|root,COG2141@2|Bacteria,2H89R@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_5646602_1	530564.Psta_3074	1.897e-217	698.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,2IWWG@203682|Planctomycetes	203682|Planctomycetes	T	Signal transducing histidine kinase, homodimeric	-	-	2.7.13.3	ko:K02487,ko:K03407,ko:K06596	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00507	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
TLS2_k127_5646602_11	1210884.HG799468_gene13821	9.141e-41	154.0	COG0835@1|root,COG0835@2|Bacteria,2IZN1@203682|Planctomycetes	203682|Planctomycetes	NT	CheW domain protein	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
TLS2_k127_5646602_10	1123242.JH636434_gene4230	7.644e-77	283.0	COG0840@1|root,COG0840@2|Bacteria,2IXQA@203682|Planctomycetes	203682|Planctomycetes	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K02660,ko:K03406	ko02020,ko02025,ko02030,map02020,map02025,map02030	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Globin,HAMP,MCPsignal,PAS_3,PAS_4,PAS_9
TLS2_k127_5646602_12	886293.Sinac_3686	2.668e-31	134.0	COG2199@1|root,COG3706@2|Bacteria,2J0C7@203682|Planctomycetes	203682|Planctomycetes	T	response regulator receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
TLS2_k127_5646602_4	1211815.CBYP010000053_gene2069	7.384e-116	390.0	COG2201@1|root,COG2201@2|Bacteria,2GMBC@201174|Actinobacteria,4ES6U@85013|Frankiales	201174|Actinobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
TLS2_k127_5646602_5	1123242.JH636436_gene432	6.185e-86	300.0	COG1352@1|root,COG1352@2|Bacteria,2IYFW@203682|Planctomycetes	203682|Planctomycetes	NT	PFAM MCP methyltransferase CheR-type	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
TLS2_k127_5646602_13	1089455.MOPEL_016_00010	1.253e-19	94.0	COG1406@1|root,COG1406@2|Bacteria,2IRB9@201174|Actinobacteria,4F71B@85018|Dermatophilaceae	201174|Actinobacteria	N	Chemotaxis phosphatase CheX	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
TLS2_k127_5646602_8	1245475.ANAE01000122_gene656	2.664e-80	283.0	COG1073@1|root,COG1073@2|Bacteria,2GNDJ@201174|Actinobacteria,4EHPW@85012|Streptosporangiales	201174|Actinobacteria	S	Dienelactone hydrolase family	-	-	3.1.1.101	ko:K21104	-	-	R11540	-	ko00000,ko01000	-	-	-	DLH,Hydrolase_4,PAF-AH_p_II
TLS2_k127_5646602_9	479435.Kfla_1142	4.673e-77	274.0	COG1073@1|root,COG1073@2|Bacteria,2GNDJ@201174|Actinobacteria	201174|Actinobacteria	Q	Belongs to the glycosyl hydrolase family 6	-	-	3.1.1.101	ko:K21104	-	-	R11540	-	ko00000,ko01000	-	-	-	Abhydrolase_5,DLH,Hydrolase_4,PAF-AH_p_II
TLS2_k127_5646602_7	1245475.ANAE01000122_gene656	4.583e-81	287.0	COG1073@1|root,COG1073@2|Bacteria,2GNDJ@201174|Actinobacteria,4EHPW@85012|Streptosporangiales	201174|Actinobacteria	S	Dienelactone hydrolase family	-	-	3.1.1.101	ko:K21104	-	-	R11540	-	ko00000,ko01000	-	-	-	DLH,Hydrolase_4,PAF-AH_p_II
TLS2_k127_5646602_2	1123322.KB904710_gene82	4.451e-140	470.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria	201174|Actinobacteria	L	DNA helicase	helD	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD_C_2
TLS2_k127_5646602_0	1229780.BN381_80197	0.0	1090.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,3UW8B@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS2_k127_5650083_7	1313172.YM304_26990	8.58e-11	63.0	COG0436@1|root,COG0436@2|Bacteria,2H440@201174|Actinobacteria,4CMXW@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS2_k127_5650083_5	383372.Rcas_3309	1.682e-85	313.0	COG5001@1|root,COG5001@2|Bacteria,2G7UT@200795|Chloroflexi,3762V@32061|Chloroflexia	32061|Chloroflexia	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_4,Response_reg
TLS2_k127_5650083_0	1157943.KB892705_gene2248	6.645e-164	532.0	COG0427@1|root,COG0427@2|Bacteria,2IAMG@201174|Actinobacteria,234WQ@1762|Mycobacteriaceae	201174|Actinobacteria	C	acetyl-CoA hydrolase	-	-	-	ko:K18288	ko00660,map00660	-	R02407,R10600	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
TLS2_k127_5650083_2	1120950.KB892784_gene202	2.515e-117	389.0	COG2171@1|root,COG2171@2|Bacteria,2IBDI@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
TLS2_k127_5650083_1	1229780.BN381_80328	6.98e-120	395.0	COG0624@1|root,COG0624@2|Bacteria,2GK09@201174|Actinobacteria,3UWHI@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Peptidase family M28	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_5650083_6	1206731.BAGB01000015_gene1802	4.722e-64	225.0	COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria,4FUQW@85025|Nocardiaceae	201174|Actinobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	GO:0008150,GO:0040007	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3275c	AIRC
TLS2_k127_5650083_3	1123320.KB889719_gene7401	9.372e-91	313.0	COG0026@1|root,COG0026@2|Bacteria,2GJCU@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
TLS2_k127_5650083_4	1313172.YM304_26970	3.351e-88	296.0	COG1974@1|root,COG1974@2|Bacteria,2GMBN@201174|Actinobacteria,4CN5D@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
TLS2_k127_567273_7	1313172.YM304_29270	2.196e-36	156.0	COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1,MFS_3
TLS2_k127_567273_4	1313172.YM304_26180	7.033e-51	188.0	COG2802@1|root,COG2802@2|Bacteria,2GNWA@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase S16, lon domain protein	-	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
TLS2_k127_567273_9	1313172.YM304_26140	2.225e-16	80.0	COG2104@1|root,COG2104@2|Bacteria,2H07J@201174|Actinobacteria	201174|Actinobacteria	H	ThiS family	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS2_k127_567273_0	1229780.BN381_410007	3.511e-139	449.0	COG0037@1|root,COG0037@2|Bacteria,2I9QA@201174|Actinobacteria	201174|Actinobacteria	D	PP-loop family	-	-	2.8.1.15	ko:K21947	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
TLS2_k127_567273_1	1313172.YM304_26120	3.598e-96	331.0	COG2519@1|root,COG2519@2|Bacteria,2GJPD@201174|Actinobacteria,4CN0Z@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	trmI	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
TLS2_k127_567273_3	1414719.CBYN010000090_gene1209	1.529e-53	203.0	COG0265@1|root,COG0265@2|Bacteria,2GJ92@201174|Actinobacteria,22K43@1653|Corynebacteriaceae	201174|Actinobacteria	O	Trypsin-like serine proteases typically periplasmic contain C-terminal PDZ domain	cvpA	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	Colicin_V,Trypsin_2
TLS2_k127_567273_8	1229780.BN381_330028	1.559e-22	115.0	28TMQ@1|root,2ZFV9@2|Bacteria,2GWN1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_567273_2	649831.L083_4671	7.122e-58	220.0	COG0395@1|root,COG0395@2|Bacteria,2GJNN@201174|Actinobacteria,4DB2R@85008|Micromonosporales	201174|Actinobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10234	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
TLS2_k127_567273_5	1996.JOFO01000026_gene4662	2.153e-48	183.0	COG1175@1|root,COG1175@2|Bacteria,2GKYS@201174|Actinobacteria,4EHI8@85012|Streptosporangiales	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10233	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
TLS2_k127_567273_6	1229780.BN381_410005	4.909e-38	144.0	COG1141@1|root,COG1141@2|Bacteria,2IKKX@201174|Actinobacteria	201174|Actinobacteria	C	ferredoxin	fdxG	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_15
TLS2_k127_5686443_5	1123270.ATUR01000003_gene898	1.034e-18	89.0	COG0438@1|root,COG0438@2|Bacteria,1R564@1224|Proteobacteria,2TTA7@28211|Alphaproteobacteria,2K1XD@204457|Sphingomonadales	204457|Sphingomonadales	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
TLS2_k127_5686443_4	479434.Sthe_3455	5.263e-20	106.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2G5WM@200795|Chloroflexi,27Y7Y@189775|Thermomicrobia	200795|Chloroflexi	DM	Capsular exopolysaccharide family	-	-	2.7.10.2	ko:K08253	-	-	-	-	ko00000,ko01000	-	-	-	CbiA,GNVR,Wzz
TLS2_k127_5686443_0	306281.AJLK01000115_gene5193	2.126e-68	248.0	COG0438@1|root,COG0438@2|Bacteria,1G1FI@1117|Cyanobacteria	1117|Cyanobacteria	M	Exostosin family	-	-	-	-	-	-	-	-	-	-	-	-	Exostosin
TLS2_k127_5686443_3	530564.Psta_1523	7.042e-35	155.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_23,Methyltransf_25
TLS2_k127_5686443_1	1173029.JH980292_gene2488	5.002e-56	203.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.243	ko:K16215	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
TLS2_k127_5686443_2	1123321.KB905817_gene5299	2.927e-54	208.0	COG1835@1|root,COG1835@2|Bacteria,2I91W@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS2_k127_5686443_6	1090318.ATTI01000001_gene483	1.269e-10	64.0	2DKYJ@1|root,30WNV@2|Bacteria,1R18V@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF1996)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1996
TLS2_k127_5712321_3	1382356.JQMP01000001_gene1206	4.194e-40	159.0	COG1268@1|root,COG1268@2|Bacteria,2GBUZ@200795|Chloroflexi,27YWE@189775|Thermomicrobia	189775|Thermomicrobia	S	BioY family	-	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
TLS2_k127_5712321_0	67373.JOBF01000014_gene4663	3.036e-140	453.0	COG0407@1|root,COG0407@2|Bacteria,2GMY6@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS2_k127_5712321_2	479432.Sros_6719	1.624e-100	349.0	COG1232@1|root,COG1232@2|Bacteria,2GMMA@201174|Actinobacteria,4EFNQ@85012|Streptosporangiales	201174|Actinobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemG	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS2_k127_5712321_7	1713.JOFV01000002_gene427	0.0002429	52.0	2EMXH@1|root,33FJS@2|Bacteria,2HY27@201174|Actinobacteria,4F2PD@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5712321_5	1313172.YM304_09330	5.249e-35	145.0	COG3764@1|root,COG3764@2|Bacteria	2|Bacteria	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
TLS2_k127_5712321_1	1229780.BN381_100020	8.316e-113	391.0	COG0815@1|root,COG0815@2|Bacteria,2GJ9F@201174|Actinobacteria,3UWR9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
TLS2_k127_5712321_4	1302286.BAOT01000002_gene210	5.524e-39	149.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,4HINN@91061|Bacilli,3F6GK@33958|Lactobacillaceae	91061|Bacilli	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
TLS2_k127_5712321_6	1179773.BN6_12450	7.701e-22	96.0	COG0488@1|root,COG0488@2|Bacteria,2GK9S@201174|Actinobacteria,4DXD2@85010|Pseudonocardiales	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	yjjK	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_5744020_14	1313172.YM304_19290	4.999e-60	215.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4CNR5@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
TLS2_k127_5744020_23	1121877.JQKF01000004_gene1087	3.709e-17	85.0	2ERJT@1|root,33J59@2|Bacteria,2HGGQ@201174|Actinobacteria,4CNDW@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3040
TLS2_k127_5744020_9	1313172.YM304_19310	1.093e-88	330.0	COG1305@1|root,COG1305@2|Bacteria,2HH1I@201174|Actinobacteria,4CP1R@84992|Acidimicrobiia	2|Bacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
TLS2_k127_5744020_20	222534.KB893746_gene2674	2.016e-39	162.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4ERVY@85013|Frankiales	201174|Actinobacteria	J	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_5744020_4	1123024.AUII01000004_gene1635	1.888e-109	362.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4DYG2@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM ATPase family associated with various cellular activities (AAA)	yeaC	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_5744020_13	1313172.YM304_36430	1.172e-80	278.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria	201174|Actinobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_5744020_15	1380393.JHVP01000006_gene3961	7.837e-54	199.0	COG1403@1|root,COG1403@2|Bacteria,2GN1W@201174|Actinobacteria,4ESID@85013|Frankiales	201174|Actinobacteria	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
TLS2_k127_5744020_11	1120936.KB907213_gene4591	1.098e-87	303.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria,4EG9K@85012|Streptosporangiales	201174|Actinobacteria	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_5744020_19	1313172.YM304_17220	7.104e-43	169.0	COG0095@1|root,COG0095@2|Bacteria,2HG9N@201174|Actinobacteria,4CN81@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TLS2_k127_5744020_22	1121926.AXWO01000003_gene848	3.387e-26	113.0	COG2001@1|root,COG2001@2|Bacteria,2IHUB@201174|Actinobacteria,4EYNZ@85014|Glycomycetales	201174|Actinobacteria	K	MraZ protein, putative antitoxin-like	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
TLS2_k127_5744020_6	1313172.YM304_19390	1.332e-102	354.0	COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria,4CN25@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
TLS2_k127_5744020_3	1313172.YM304_19410	1.943e-112	386.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4CN0Q@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
TLS2_k127_5744020_7	1313172.YM304_19420	5.304e-96	329.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4CNID@84992|Acidimicrobiia	84992|Acidimicrobiia	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	-	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_5744020_24	1384484.AEQU_1427	7.427e-17	81.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4CUCK@84998|Coriobacteriia	84998|Coriobacteriia	M	Belongs to the MurCDEF family. MurE subfamily	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_5744020_2	1229780.BN381_140011	4.976e-134	436.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,3UWA7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0008150,GO:0040007	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
TLS2_k127_5744020_10	1313172.YM304_19440	4.111e-88	319.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4CN07@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
TLS2_k127_5744020_8	484770.UFO1_2516	2.55e-92	316.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,4H3RE@909932|Negativicutes	909932|Negativicutes	D	TIGRFAM stage V sporulation protein E, cell division protein FtsW	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
TLS2_k127_5744020_16	767434.Fraau_0372	7.286e-52	198.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1X3JZ@135614|Xanthomonadales	135614|Xanthomonadales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
TLS2_k127_5744020_5	1313172.YM304_19470	3.863e-104	361.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4CMTG@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_5744020_12	1313172.YM304_19480	2.36e-83	304.0	COG0812@1|root,COG0812@2|Bacteria,2HG0Y@201174|Actinobacteria,4CMXR@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
TLS2_k127_5744020_26	469371.Tbis_1409	2.015e-12	81.0	COG1589@1|root,COG1589@2|Bacteria,2H4A4@201174|Actinobacteria,4E3DB@85010|Pseudonocardiales	201174|Actinobacteria	D	Cell division protein FtsQ	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
TLS2_k127_5744020_1	1229780.BN381_140005	3.674e-169	538.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria,3UW88@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS2_k127_5744020_17	1229780.BN381_140004	5.448e-46	174.0	COG1496@1|root,COG1496@2|Bacteria,2GN1M@201174|Actinobacteria,3UWY4@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Multi-copper polyphenol oxidoreductase laccase	yfiH	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
TLS2_k127_5744020_18	1313172.YM304_19520	1.742e-44	182.0	COG0325@1|root,COG0325@2|Bacteria,2HGAF@201174|Actinobacteria,4CN9H@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Alanine racemase, N-terminal domain	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
TLS2_k127_5744020_21	1229780.BN381_140002	1.443e-32	134.0	COG1799@1|root,COG1799@2|Bacteria,2GNVH@201174|Actinobacteria,3UWTH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
TLS2_k127_5744020_28	1229780.BN381_430082	4.292e-09	68.0	COG3599@1|root,COG3599@2|Bacteria	2|Bacteria	D	regulation of cell shape	-	-	-	-	-	-	-	-	-	-	-	-	DivIVA
TLS2_k127_5744020_0	1194972.MVAC_19668	6.611e-295	920.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,233C2@1762|Mycobacteriaceae	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
TLS2_k127_5764083_1	208444.JNYY01000011_gene2935	1.165e-218	689.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria,4E23I@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA polymerase Ligase (LigD)	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS2_k127_5764083_14	1341646.CBMO010000122_gene1996	9.78e-51	203.0	COG3324@1|root,COG3324@2|Bacteria,2I6WX@201174|Actinobacteria,233G3@1762|Mycobacteriaceae	201174|Actinobacteria	E	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5764083_7	1449353.JQMQ01000005_gene3818	9.242e-89	300.0	COG0005@1|root,COG0005@2|Bacteria,2GKEI@201174|Actinobacteria,2NG4K@228398|Streptacidiphilus	201174|Actinobacteria	F	Phosphorylase superfamily	punA	GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_5764083_8	649638.Trad_0374	1.327e-88	310.0	KOG2524@1|root,2ZJ84@2|Bacteria	2|Bacteria	S	Potential Queuosine, Q, salvage protein family	-	-	-	-	-	-	-	-	-	-	-	-	Q_salvage
TLS2_k127_5764083_3	73044.JNXP01000008_gene3305	1.093e-158	520.0	COG1109@1|root,COG1109@2|Bacteria,2GJ3Q@201174|Actinobacteria	201174|Actinobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain II	pmmB	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_5764083_18	525909.Afer_1771	2.647e-15	88.0	2AN4Y@1|root,31D2Q@2|Bacteria,2HGQN@201174|Actinobacteria,4CNSU@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5764083_5	1380356.JNIK01000005_gene1069	6.29e-116	396.0	COG2199@1|root,COG2200@1|root,COG2202@1|root,COG4250@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG2202@2|Bacteria,COG4250@2|Bacteria,2GNSQ@201174|Actinobacteria,4EUZC@85013|Frankiales	201174|Actinobacteria	T	Sensory domain in DIguanylate Cyclases and Two-component system	-	-	-	-	-	-	-	-	-	-	-	-	DICT,EAL,GGDEF,PAS_9
TLS2_k127_5764083_2	344747.PM8797T_16308	6.142e-198	630.0	COG0397@1|root,COG0397@2|Bacteria,2J08F@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the UPF0061 (SELO) family	-	-	-	-	-	-	-	-	-	-	-	-	UPF0061
TLS2_k127_5764083_12	436229.JOEH01000059_gene1268	2.599e-78	269.0	COG1878@1|root,COG1878@2|Bacteria,2I66K@201174|Actinobacteria,2NH8N@228398|Streptacidiphilus	201174|Actinobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_5764083_16	1137269.AZWL01000002_gene6244	8.927e-33	131.0	2DM0Y@1|root,318KY@2|Bacteria,2IMIX@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF1992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1992
TLS2_k127_5764083_13	1125863.JAFN01000001_gene1121	2.824e-63	226.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1MUI0@1224|Proteobacteria,42MCB@68525|delta/epsilon subdivisions,2WIRJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Belongs to the precorrin methyltransferase family	hemD	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
TLS2_k127_5764083_4	1051632.TPY_0561	1.13e-137	454.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia	186801|Clostridia	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_5764083_0	929712.KI912613_gene4773	9.194e-230	732.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CRMY@84995|Rubrobacteria	84995|Rubrobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_5764083_17	1313172.YM304_41540	1.038e-30	130.0	COG1672@1|root,COG1672@2|Bacteria,2IGAA@201174|Actinobacteria	201174|Actinobacteria	S	Electron transfer DM13	-	-	-	-	-	-	-	-	-	-	-	-	DM13
TLS2_k127_5764083_19	661478.OP10G_4726	0.0001788	53.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DUF4101,DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_5764083_9	1424334.W822_09050	2.772e-85	290.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2W22A@28216|Betaproteobacteria,3T6CE@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_5764083_11	1386089.N865_17375	2.405e-79	285.0	COG1073@1|root,COG1073@2|Bacteria,2I0E5@201174|Actinobacteria,4FJN1@85021|Intrasporangiaceae	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TLS2_k127_5764083_6	55952.BU52_03495	2.072e-103	354.0	arCOG06481@1|root,2ZB4E@2|Bacteria,2I95D@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5764083_15	1206743.BAGM01000096_gene2375	6.662e-33	130.0	COG2050@1|root,COG2050@2|Bacteria,2HMKZ@201174|Actinobacteria,4FU6N@85025|Nocardiaceae	201174|Actinobacteria	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
TLS2_k127_586317_14	877455.Metbo_1572	4.823e-11	71.0	arCOG10865@1|root,arCOG10865@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CHB_HEX_C_1
TLS2_k127_586317_4	1386089.N865_15100	4.02e-93	319.0	COG0654@1|root,COG0654@2|Bacteria,2I2TH@201174|Actinobacteria	201174|Actinobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS2_k127_586317_6	1238182.C882_0312	3.07e-64	228.0	COG1765@1|root,COG1765@2|Bacteria,1RBJN@1224|Proteobacteria,2VF54@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_586317_0	1380390.JIAT01000013_gene123	2.121e-243	771.0	COG2267@1|root,COG4671@1|root,COG2267@2|Bacteria,COG4671@2|Bacteria	2|Bacteria	I	Glycosyl Transferase	yvaM	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Glyco_tran_28_C,Hydrolase_4
TLS2_k127_586317_12	350058.Mvan_3869	3.711e-33	143.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
TLS2_k127_586317_10	1121272.KB903249_gene1629	1.06e-49	199.0	COG1309@1|root,COG1309@2|Bacteria,2IHGM@201174|Actinobacteria,4DD7T@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_586317_5	931627.MycrhDRAFT_2178	6.669e-69	256.0	COG0741@1|root,COG0741@2|Bacteria,2IBCH@201174|Actinobacteria,2359I@1762|Mycobacteriaceae	201174|Actinobacteria	M	transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1460,NLPC_P60,SLT,SLT_2
TLS2_k127_586317_11	710421.Mycch_1157	1.06e-33	139.0	COG0500@1|root,COG2226@2|Bacteria,2HWAV@201174|Actinobacteria,232JV@1762|Mycobacteriaceae	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_586317_2	1242864.D187_008224	2.495e-133	433.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,42MVI@68525|delta/epsilon subdivisions,2WPP7@28221|Deltaproteobacteria,2YTYB@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_586317_1	1229780.BN381_80377	1.868e-146	478.0	COG1894@1|root,COG1894@2|Bacteria,2GNN9@201174|Actinobacteria,3UXSE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	nuoF_1	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,NADH_4Fe-4S
TLS2_k127_586317_9	469371.Tbis_3474	8.482e-52	191.0	COG1024@1|root,COG1024@2|Bacteria,2I9VC@201174|Actinobacteria,4DX6Z@85010|Pseudonocardiales	201174|Actinobacteria	I	PFAM Enoyl-CoA hydratase isomerase	echA3	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_586317_7	1283287.KB822589_gene1202	8.03e-59	220.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4DWF4@85009|Propionibacteriales	201174|Actinobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4
TLS2_k127_586317_8	1122247.C731_1921	4.861e-52	198.0	COG3178@1|root,COG3178@2|Bacteria,2GN8T@201174|Actinobacteria,23F8B@1762|Mycobacteriaceae	201174|Actinobacteria	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	EcKinase
TLS2_k127_586317_3	357808.RoseRS_0965	3.06e-122	399.0	COG0462@1|root,COG0462@2|Bacteria,2G5T8@200795|Chloroflexi,376D2@32061|Chloroflexia	32061|Chloroflexia	F	Phosphoribosyl synthetase-associated domain	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
TLS2_k127_586317_16	547163.BN979_03720	8.255e-05	53.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
TLS2_k127_586317_13	1089453.GOSPT_133_00210	6.911e-25	108.0	COG1247@1|root,COG1247@2|Bacteria,2IHSY@201174|Actinobacteria,4GDER@85026|Gordoniaceae	201174|Actinobacteria	M	Acetyltransferase (GNAT) domain	yncA	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
TLS2_k127_599173_5	1236902.ANAS01000020_gene1560	9.76e-55	207.0	COG0834@1|root,COG0834@2|Bacteria,2GN71@201174|Actinobacteria,4ENY5@85012|Streptosporangiales	201174|Actinobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
TLS2_k127_599173_8	1313172.YM304_22420	1.687e-28	121.0	COG0216@1|root,COG0216@2|Bacteria	2|Bacteria	J	translation release factor activity	prfA	-	-	ko:K02835,ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
TLS2_k127_599173_1	443218.AS9A_1669	8.43e-189	601.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	surE2	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid,F5_F8_type_C,FIVAR,Flg_new,Glyco_hydro_20,Glyco_hydro_20b,Mob_Pre,MucBP
TLS2_k127_599173_9	1121380.JNIW01000008_gene1625	1.311e-07	58.0	COG2608@1|root,COG2608@2|Bacteria,1WKNR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Heavy metal transport detoxification protein	-	-	-	-	-	-	-	-	-	-	-	-	HMA
TLS2_k127_599173_0	405948.SACE_6203	0.0	1267.0	COG1643@1|root,COG1643@2|Bacteria,2GIWX@201174|Actinobacteria,4E02F@85010|Pseudonocardiales	201174|Actinobacteria	L	TIGRFAM ATP-dependent helicase HrpA	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
TLS2_k127_599173_7	1283287.KB822579_gene2190	1.8e-30	138.0	COG2199@1|root,COG3706@2|Bacteria,2IA4H@201174|Actinobacteria,4DSD3@85009|Propionibacteriales	201174|Actinobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
TLS2_k127_599173_4	710687.KI912270_gene2547	3.646e-56	218.0	COG4325@1|root,COG4325@2|Bacteria,2GWFP@201174|Actinobacteria,2387T@1762|Mycobacteriaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2254)	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009405,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0051704	-	-	-	-	-	-	-	-	-	-	DUF2254
TLS2_k127_599173_2	44060.JODL01000002_gene2338	1.003e-99	334.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_599173_3	1313172.YM304_41550	6.865e-87	294.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,4CN0Y@84992|Acidimicrobiia	84992|Acidimicrobiia	U	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_599173_6	1121272.KB903249_gene2557	1.247e-51	190.0	COG3187@1|root,COG3187@2|Bacteria,2I9ND@201174|Actinobacteria,4DK1I@85008|Micromonosporales	201174|Actinobacteria	O	META domain	hslJ	-	-	ko:K03668	-	-	-	-	ko00000	-	-	-	META
TLS2_k127_6031520_4	502025.Hoch_2073	1.727e-74	266.0	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,42TE9@68525|delta/epsilon subdivisions,2WPGF@28221|Deltaproteobacteria,2YUH5@29|Myxococcales	28221|Deltaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_6031520_0	1313172.YM304_27040	2.689e-209	660.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4CMWG@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TLS2_k127_6031520_6	937777.Deipe_2720	9.545e-44	175.0	COG3231@1|root,COG3231@2|Bacteria,1WMRR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Belongs to the aminoglycoside phosphotransferase family	-	-	2.7.1.95	ko:K00897	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	APH
TLS2_k127_6031520_3	1313172.YM304_27020	1.966e-99	333.0	COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria,4CN5X@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
TLS2_k127_6031520_5	1229780.BN381_80322	8.557e-59	219.0	COG0253@1|root,COG0253@2|Bacteria,2GKUD@201174|Actinobacteria,3UWMJ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
TLS2_k127_6031520_1	1229780.BN381_80323	6.988e-168	552.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,3UW9C@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TLS2_k127_6031520_2	1313172.YM304_26990	2.61e-133	434.0	COG0436@1|root,COG0436@2|Bacteria,2H440@201174|Actinobacteria,4CMXW@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS2_k127_6058222_10	1229780.BN381_330050	5.466e-25	121.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_6058222_3	1229780.BN381_330051	1.846e-122	401.0	COG0052@1|root,COG0052@2|Bacteria,2GMYC@201174|Actinobacteria,3UWBA@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
TLS2_k127_6058222_6	1229780.BN381_330052	2.885e-86	293.0	COG0264@1|root,COG0264@2|Bacteria,2GK4M@201174|Actinobacteria,3UWKI@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
TLS2_k127_6058222_5	1229780.BN381_330053	7.087e-109	361.0	COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,3UW78@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS2_k127_6058222_8	1313172.YM304_27460	1.919e-62	223.0	COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4CN2Z@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
TLS2_k127_6058222_9	1229780.BN381_330055	1.423e-49	194.0	COG0575@1|root,COG0575@2|Bacteria,2I7ZA@201174|Actinobacteria,3UWMF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TLS2_k127_6058222_2	1229780.BN381_330056	6.022e-148	479.0	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria,3UWAE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2870c	DXPR_C,DXP_redisom_C,DXP_reductoisom
TLS2_k127_6058222_7	1313172.YM304_27430	1.763e-71	259.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4CMZX@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
TLS2_k127_6058222_0	1313172.YM304_27420	2.999e-206	647.0	COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,4CMRA@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TLS2_k127_6058222_4	1395571.TMS3_0115105	7.357e-120	418.0	COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,1RP39@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_6058222_1	298655.KI912266_gene1541	5.247e-190	603.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,4EUFB@85013|Frankiales	201174|Actinobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
TLS2_k127_6088871_17	1313172.YM304_04580	7.165e-13	81.0	COG1595@1|root,COG1595@2|Bacteria,2IHVZ@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6088871_0	1313172.YM304_21870	3.425e-144	462.0	COG2070@1|root,COG2070@2|Bacteria,2GKA6@201174|Actinobacteria	201174|Actinobacteria	T	2-nitropropane dioxygenase	fabK	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
TLS2_k127_6088871_3	994479.GL877879_gene5807	9.049e-82	277.0	COG0406@1|root,COG2072@1|root,COG0406@2|Bacteria,COG2072@2|Bacteria,2HUBQ@201174|Actinobacteria,4E141@85010|Pseudonocardiales	201174|Actinobacteria	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TLS2_k127_6088871_5	1280950.HJO_13351	3.541e-61	233.0	COG0111@1|root,COG0111@2|Bacteria,1RKWR@1224|Proteobacteria,2UB4X@28211|Alphaproteobacteria,43Z5E@69657|Hyphomonadaceae	28211|Alphaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase family protein	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_6088871_15	374847.Kcr_0215	4.866e-19	91.0	COG5496@1|root,arCOG04331@2157|Archaea	2157|Archaea	S	thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_6088871_2	1056816.JAFQ01000004_gene4078	1.212e-92	315.0	COG0596@1|root,COG0596@2|Bacteria,2HHT8@201174|Actinobacteria,4G09S@85025|Nocardiaceae	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_6088871_1	163908.KB235896_gene1810	7.165e-118	383.0	COG0235@1|root,COG0235@2|Bacteria,1G10W@1117|Cyanobacteria,1HM3T@1161|Nostocales	1117|Cyanobacteria	G	PFAM Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
TLS2_k127_6088871_13	234267.Acid_0127	3.391e-33	137.0	COG1102@1|root,COG1102@2|Bacteria	2|Bacteria	F	Psort location Cytoplasmic, score	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Cytidylate_kin2,GAF_2,Pribosyltran
TLS2_k127_6088871_6	1229780.BN381_40086	5.758e-57	203.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,3UWPC@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_6088871_10	1313172.YM304_25720	2.954e-45	168.0	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,4CN3Y@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
TLS2_k127_6088871_14	575594.ACOH01000020_gene1488	2.911e-32	134.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,4HFZ2@91061|Bacilli,3F56C@33958|Lactobacillaceae	91061|Bacilli	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS2_k127_6088871_8	1313172.YM304_25710	9.496e-50	198.0	COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria,4CN7E@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_6088871_9	1123320.KB889562_gene6867	1.822e-47	175.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria	201174|Actinobacteria	T	(FHA) domain	garA	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
TLS2_k127_6088871_11	1313172.YM304_25690	3.438e-45	171.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4CN5F@84992|Acidimicrobiia	84992|Acidimicrobiia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
TLS2_k127_6088871_7	1313172.YM304_25680	1.209e-50	187.0	COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4CN98@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_6088871_12	1123024.AUII01000016_gene1256	7.067e-44	163.0	COG0537@1|root,COG0537@2|Bacteria,2IKWU@201174|Actinobacteria	201174|Actinobacteria	FG	Histidine triad (Hit) protein	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
TLS2_k127_6088871_16	459495.SPLC1_S300120	3.011e-17	93.0	COG3463@1|root,COG3463@2|Bacteria,1G2XA@1117|Cyanobacteria,1H828@1150|Oscillatoriales	1117|Cyanobacteria	S	membrane protein (DUF2079)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2079
TLS2_k127_6128364_3	1313172.YM304_33450	2.018e-70	244.0	COG1670@1|root,COG1670@2|Bacteria,2HFKU@201174|Actinobacteria,4CP4F@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS2_k127_6128364_4	1458357.BG58_34990	2.349e-31	138.0	28MHU@1|root,2ZAUM@2|Bacteria,1R3RK@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6128364_0	1229780.BN381_630011	1.608e-129	426.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria,3UWTN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_6128364_1	1229780.BN381_630010	2.467e-116	381.0	COG0204@1|root,COG0204@2|Bacteria,2GJKH@201174|Actinobacteria,3UXD2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Phosphate acyltransferases	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TLS2_k127_6128364_2	1313172.YM304_32840	9.425e-77	268.0	COG1468@1|root,COG1468@2|Bacteria,2HE3R@201174|Actinobacteria,4CP30@84992|Acidimicrobiia	84992|Acidimicrobiia	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
TLS2_k127_6128364_5	1313172.YM304_32820	2.398e-17	86.0	2CK2C@1|root,2ZY21@2|Bacteria,2HE72@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6176152_13	1123320.KB889697_gene8849	1.841e-48	181.0	COG2050@1|root,COG2050@2|Bacteria,2IJ8E@201174|Actinobacteria	201174|Actinobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_6176152_3	1229780.BN381_80311	1.015e-179	571.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,3UW96@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TLS2_k127_6176152_12	269084.syc1907_c	4.711e-54	200.0	COG0229@1|root,COG0229@2|Bacteria,1G5S6@1117|Cyanobacteria,1H0VR@1129|Synechococcus	1117|Cyanobacteria	C	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
TLS2_k127_6176152_9	285514.JNWO01000040_gene473	3.601e-68	239.0	COG0504@1|root,COG0504@2|Bacteria,2I8KR@201174|Actinobacteria	201174|Actinobacteria	F	Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
TLS2_k127_6176152_11	258533.BN977_03704	1.985e-63	219.0	COG0346@1|root,COG0346@2|Bacteria,2IMNF@201174|Actinobacteria,23ACV@1762|Mycobacteriaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_6176152_6	1229780.BN381_810009	6.665e-109	360.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_6176152_10	1463934.JOCF01000102_gene7416	2.336e-64	228.0	COG1670@1|root,COG1670@2|Bacteria,2IQW2@201174|Actinobacteria	201174|Actinobacteria	J	PFAM GCN5-related N-acetyltransferase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006104,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_6176152_4	1469245.JFBG01000054_gene2100	5.346e-168	537.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1T236@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
TLS2_k127_6176152_14	1313172.YM304_16510	5.781e-44	173.0	COG0558@1|root,COG0558@2|Bacteria,2HGCB@201174|Actinobacteria,4CNAE@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_6176152_2	1313172.YM304_16500	7.302e-184	584.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4CMWG@84992|Acidimicrobiia	2|Bacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	rimO	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
TLS2_k127_6176152_15	1246459.KB898374_gene3976	1.558e-20	98.0	COG2114@1|root,COG2114@2|Bacteria,1Q8YH@1224|Proteobacteria,2VD35@28211|Alphaproteobacteria,4BA5X@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
TLS2_k127_6176152_16	1463821.JOGR01000007_gene122	2.179e-12	76.0	COG3595@1|root,COG3595@2|Bacteria,2GJZC@201174|Actinobacteria,4EYMD@85014|Glycomycetales	201174|Actinobacteria	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_6176152_7	1112216.JH594425_gene3178	3.948e-92	312.0	COG3386@1|root,COG3386@2|Bacteria,1MXVD@1224|Proteobacteria,2TVCW@28211|Alphaproteobacteria,2K1RT@204457|Sphingomonadales	204457|Sphingomonadales	G	SMP-30/Gluconolaconase/LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
TLS2_k127_6176152_8	1313172.YM304_13530	3.472e-69	246.0	COG0530@1|root,COG0530@2|Bacteria,2GJR3@201174|Actinobacteria	201174|Actinobacteria	P	PFAM sodium calcium exchanger	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
TLS2_k127_6176152_1	1229780.BN381_80302	2.065e-223	719.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,3UW6P@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TLS2_k127_6176152_0	1313172.YM304_16400	2.98e-233	734.0	COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,4CMS5@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Zn-dependent metallo-hydrolase RNA specificity domain	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
TLS2_k127_6176152_5	243365.CV_2048	4.365e-111	368.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2VIQ4@28216|Betaproteobacteria,2KPQN@206351|Neisseriales	28216|Betaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_6274347_18	1472418.BBJC01000006_gene2555	1.52e-07	55.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274,ko:K15408	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS2_k127_6274347_7	715451.ambt_09275	4.155e-71	270.0	COG1622@1|root,COG3474@1|root,COG1622@2|Bacteria,COG3474@2|Bacteria,1MWHZ@1224|Proteobacteria,1S5PJ@1236|Gammaproteobacteria,469N9@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Cytochrome C oxidase subunit II, periplasmic domain	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,Cytochrom_C
TLS2_k127_6274347_3	106370.Francci3_2489	1.017e-121	411.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4ERM6@85013|Frankiales	201174|Actinobacteria	C	Cytochrome b	qcrB	-	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
TLS2_k127_6274347_10	1123251.ATWM01000004_gene1936	6.223e-40	161.0	COG0723@1|root,COG0723@2|Bacteria,2GIX6@201174|Actinobacteria,4FE3Q@85021|Intrasporangiaceae	201174|Actinobacteria	C	Ubiquinol-cytochrome C reductase	qcrA	-	-	ko:K03890	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Rieske
TLS2_k127_6274347_9	298655.KI912267_gene7420	4.663e-40	166.0	COG2010@1|root,COG2010@2|Bacteria,2GKUB@201174|Actinobacteria,4ESET@85013|Frankiales	201174|Actinobacteria	C	cytochrome C	qcrC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03889	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_CBB3
TLS2_k127_6274347_16	1229780.BN381_140045	4.672e-19	91.0	2ES7R@1|root,33JSG@2|Bacteria,2I1DU@201174|Actinobacteria,3UXPZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6274347_15	211165.AJLN01000119_gene901	2.27e-22	113.0	COG0642@1|root,COG0784@1|root,COG3447@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3447@2|Bacteria,1G09B@1117|Cyanobacteria,1JJQ7@1189|Stigonemataceae	1117|Cyanobacteria	T	MASE1	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE1,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_6274347_8	1283299.AUKG01000001_gene2300	3.184e-59	231.0	COG0642@1|root,COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2208@2|Bacteria,2GNG4@201174|Actinobacteria,4CQ08@84995|Rubrobacteria	84995|Rubrobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,TetR_N
TLS2_k127_6274347_19	1209984.BN978_05893	0.0001879	47.0	2EGHN@1|root,33A9R@2|Bacteria,2GSZ1@201174|Actinobacteria,23BB4@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6274347_5	1229780.BN381_140043	2.095e-104	352.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16,HEAT_2
TLS2_k127_6274347_2	1313172.YM304_19140	4.001e-139	455.0	COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,4CN28@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyl transferases group 1	-	-	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_6274347_17	1229780.BN381_140041	2.739e-11	74.0	28Z2K@1|root,2ZKV3@2|Bacteria,2HA4X@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6274347_11	1313172.YM304_19160	1.391e-39	159.0	COG2867@1|root,COG2867@2|Bacteria,2IFH4@201174|Actinobacteria,4CN9D@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TLS2_k127_6274347_14	638303.Thal_0642	6.473e-32	143.0	COG1503@1|root,COG1503@2|Bacteria	2|Bacteria	J	translation release factor activity	yocB	GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	-
TLS2_k127_6274347_6	1313172.YM304_19170	8.531e-75	276.0	COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,4CNH1@84992|Acidimicrobiia	201174|Actinobacteria	G	ROK family	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_6274347_1	644282.Deba_1381	6.197e-152	489.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	yfdZ	-	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_6274347_13	1229780.BN381_140034	4.18e-33	137.0	COG1309@1|root,COG1309@2|Bacteria,2GXGA@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_6274347_12	1313172.YM304_19200	4.119e-39	157.0	COG0317@1|root,COG0317@2|Bacteria	2|Bacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	sdaAB	-	2.7.6.5,3.1.7.2,4.3.1.17,4.3.1.19	ko:K01139,ko:K01752,ko:K01754	ko00230,ko00260,ko00270,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00230,map00260,map00270,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00336,R00429,R00590,R00996	RC00002,RC00078,RC00331,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	ACT,HD_4,PALP,RelA_SpoT,SDH_beta
TLS2_k127_6274347_0	1229780.BN381_140033	5.047e-204	651.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,3UWF2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	-	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS2_k127_6274347_4	1229780.BN381_140032	5.071e-112	368.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,3UWQ8@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
TLS2_k127_6287847_1	1313172.YM304_08900	2.129e-147	473.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4CNP6@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_6287847_4	471852.Tcur_1342	6.401e-45	169.0	COG0662@1|root,COG0662@2|Bacteria,2IMHT@201174|Actinobacteria,4EKA7@85012|Streptosporangiales	201174|Actinobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,EutQ
TLS2_k127_6287847_2	1151122.AQYD01000006_gene1735	4.642e-82	288.0	COG1234@1|root,COG2333@1|root,COG1234@2|Bacteria,COG2333@2|Bacteria,2IP3R@201174|Actinobacteria	201174|Actinobacteria	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_6287847_0	469383.Cwoe_4037	5.663e-155	509.0	COG3590@1|root,COG3590@2|Bacteria,2ICCH@201174|Actinobacteria	201174|Actinobacteria	O	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6287847_3	67352.JODS01000027_gene2393	1.014e-64	233.0	COG1295@1|root,COG1295@2|Bacteria	2|Bacteria	S	lipopolysaccharide transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
TLS2_k127_6287847_5	1283299.AUKG01000001_gene2158	3.803e-09	64.0	2B8TX@1|root,32240@2|Bacteria,2HRST@201174|Actinobacteria,4CTW1@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6329932_5	1172188.KB911827_gene4184	1.197e-89	301.0	COG0421@1|root,COG0421@2|Bacteria,2I2TN@201174|Actinobacteria,4FFDJ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6329932_3	1032480.MLP_14460	3.121e-126	427.0	COG1793@1|root,COG1793@2|Bacteria,2I2EA@201174|Actinobacteria,4DP0M@85009|Propionibacteriales	201174|Actinobacteria	L	ATP dependent DNA ligase C terminal region	ligC	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
TLS2_k127_6329932_7	471852.Tcur_0468	4.025e-66	233.0	COG0412@1|root,COG0412@2|Bacteria,2IG4Y@201174|Actinobacteria,4EM0U@85012|Streptosporangiales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TLS2_k127_6329932_11	357808.RoseRS_0176	1.497e-19	102.0	COG0477@1|root,COG2814@2|Bacteria,2G6D7@200795|Chloroflexi,3763C@32061|Chloroflexia	32061|Chloroflexia	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_6329932_0	1313172.YM304_37200	5.456e-281	873.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CMPB@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_6329932_4	1229780.BN381_150064	2.81e-111	368.0	COG1409@1|root,COG1409@2|Bacteria,2IDNH@201174|Actinobacteria	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos,Pur_ac_phosph_N
TLS2_k127_6329932_2	1313172.YM304_02580	4.287e-137	456.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS2_k127_6329932_8	469371.Tbis_1218	7.177e-49	185.0	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria,4E3JQ@85010|Pseudonocardiales	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS2_k127_6329932_6	649638.Trad_2940	6.92e-80	274.0	COG0656@1|root,COG0656@2|Bacteria,1WMHW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_6329932_13	32057.KB217478_gene5344	1.529e-09	69.0	2DBMC@1|root,2Z9YC@2|Bacteria,1G29C@1117|Cyanobacteria,1HREY@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6329932_10	1385521.N803_05695	3.322e-20	99.0	COG5662@1|root,COG5662@2|Bacteria,2I196@201174|Actinobacteria,4FHP7@85021|Intrasporangiaceae	201174|Actinobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_6329932_9	68170.KL590478_gene8136	6.071e-39	151.0	COG1595@1|root,COG1595@2|Bacteria,2GM3E@201174|Actinobacteria,4E2BH@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
TLS2_k127_6329932_12	196367.JNFG01000030_gene8547	1.814e-16	85.0	COG3794@1|root,COG3794@2|Bacteria,1NKZ5@1224|Proteobacteria,2VW1T@28216|Betaproteobacteria,1K8BA@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
TLS2_k127_6329932_1	1206731.BAGB01000159_gene6110	1.687e-162	532.0	COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,2GKEU@201174|Actinobacteria,4FVRW@85025|Nocardiaceae	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC_tran,FHA,Yop-YscD_cpl
TLS2_k127_6341244_4	42256.RradSPS_0752	9.645e-09	66.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	mprF	-	-	ko:K07027,ko:K20468	-	-	-	-	ko00000,ko02000	4.D.2,4.D.2.4.1	-	-	LPG_synthase_TM
TLS2_k127_6341244_5	1499967.BAYZ01000005_gene5436	3.511e-07	63.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,2NQY2@2323|unclassified Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT,PMT_2,TPR_19
TLS2_k127_6341244_2	1229780.BN381_330026	2.02e-52	205.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	mprF	-	-	ko:K07027,ko:K20468	-	-	-	-	ko00000,ko02000	4.D.2,4.D.2.4.1	-	-	LPG_synthase_TM
TLS2_k127_6341244_0	1229780.BN381_330027	6.214e-93	318.0	COG0463@1|root,COG0463@2|Bacteria,2I3C0@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
TLS2_k127_6341244_3	1229780.BN381_330025	8.093e-48	191.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
TLS2_k127_6341244_1	525909.Afer_1748	3.629e-62	223.0	COG1682@1|root,COG1682@2|Bacteria,2GP5K@201174|Actinobacteria,4CNBI@84992|Acidimicrobiia	84992|Acidimicrobiia	U	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_6347081_1	685727.REQ_13600	1.262e-115	384.0	COG3416@1|root,COG3416@2|Bacteria,2HVVA@201174|Actinobacteria,4FXR5@85025|Nocardiaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS2_k127_6347081_9	1449976.KALB_3730	1.029e-48	180.0	COG3153@1|root,COG3153@2|Bacteria,2IKX0@201174|Actinobacteria,4E3PT@85010|Pseudonocardiales	201174|Actinobacteria	S	Acetyltransferase (GNAT) family	-	-	-	ko:K03824,ko:K09964	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_7,Acetyltransf_9
TLS2_k127_6347081_7	1313172.YM304_13510	9.306e-54	199.0	COG0596@1|root,COG0596@2|Bacteria,2IA2Y@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
TLS2_k127_6347081_18	1280380.KR100_08760	2.096e-24	108.0	COG1853@1|root,COG1853@2|Bacteria,1G2RV@1117|Cyanobacteria,1GYSV@1129|Synechococcus	1117|Cyanobacteria	S	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TLS2_k127_6347081_6	1120950.KB892782_gene291	1.324e-70	247.0	COG3832@1|root,COG3832@2|Bacteria,2HK0M@201174|Actinobacteria,4DW6I@85009|Propionibacteriales	201174|Actinobacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6347081_19	33876.JNXY01000006_gene1349	1.734e-06	56.0	COG2909@1|root,COG2909@2|Bacteria,2GM03@201174|Actinobacteria,4D9RB@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_22,GerE
TLS2_k127_6347081_15	1313172.YM304_12170	4.592e-30	121.0	COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
TLS2_k127_6347081_16	1205910.B005_4152	3.938e-29	124.0	COG1309@1|root,COG1309@2|Bacteria,2IG4Q@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_6347081_8	479434.Sthe_0289	4.481e-50	190.0	COG1668@1|root,COG1668@2|Bacteria	2|Bacteria	CP	transmembrane transport	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC2_membrane_4
TLS2_k127_6347081_2	1120934.KB894405_gene5538	8.53e-115	396.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6347081_10	1298863.AUEP01000011_gene511	3.129e-45	177.0	COG2197@1|root,COG2197@2|Bacteria,2IATK@201174|Actinobacteria,4DQAB@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_6347081_4	1048339.KB913029_gene4056	1.05e-83	287.0	COG0426@1|root,COG0426@2|Bacteria,2GJT6@201174|Actinobacteria,4EWE7@85013|Frankiales	201174|Actinobacteria	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
TLS2_k127_6347081_12	1313172.YM304_09940	7.289e-41	157.0	2EN76@1|root,33FV1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6347081_0	1123392.AQWL01000002_gene1698	0.0	1043.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,1KS0K@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
TLS2_k127_6347081_14	1048339.KB913029_gene3755	6.151e-31	130.0	2FHWH@1|root,349PK@2|Bacteria,2GYIN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6347081_11	1048339.KB913029_gene3756	3.01e-43	165.0	COG1595@1|root,COG1595@2|Bacteria,2IRNG@201174|Actinobacteria,4ETAM@85013|Frankiales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6347081_3	1370125.AUWT01000063_gene886	6.514e-99	330.0	COG2761@1|root,COG2761@2|Bacteria,2H7YD@201174|Actinobacteria,2359N@1762|Mycobacteriaceae	201174|Actinobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
TLS2_k127_6347081_17	2055.JNXA01000005_gene330	3.111e-26	127.0	COG1028@1|root,COG1028@2|Bacteria,2GMJU@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_6347081_5	1123240.ATVO01000009_gene737	4.693e-72	258.0	2C8FR@1|root,34BJJ@2|Bacteria,1P3IC@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6347081_13	298654.FraEuI1c_4289	1.413e-37	159.0	COG2199@1|root,COG2199@2|Bacteria	2|Bacteria	T	diguanylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_4,PAS_9
TLS2_k127_638792_1	1229780.BN381_30024	1.783e-165	533.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,3UW8Z@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Glucose-6-phosphate dehydrogenase, C-terminal domain	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TLS2_k127_638792_3	644966.Tmar_0154	5.067e-49	188.0	COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,25C8E@186801|Clostridia,3WD2N@538999|Clostridiales incertae sedis	186801|Clostridia	J	Protein of unknown function (DUF1385)	prmC	-	-	-	-	-	-	-	-	-	-	-	DUF1385,MTS
TLS2_k127_638792_0	1283299.AUKG01000002_gene4080	5.139e-275	863.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4CR1R@84995|Rubrobacteria	84995|Rubrobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TLS2_k127_638792_2	517722.AEUE01000001_gene2674	9.126e-95	323.0	COG2159@1|root,COG2159@2|Bacteria,1MVTS@1224|Proteobacteria,2VGQX@28211|Alphaproteobacteria,2KE5I@204457|Sphingomonadales	204457|Sphingomonadales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_638792_4	222534.KB893721_gene911	3.505e-28	121.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_6443800_0	1380390.JIAT01000012_gene3163	1.712e-167	541.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4CRJZ@84995|Rubrobacteria	84995|Rubrobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K12429	-	-	-	-	ko00000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_6443800_2	247633.GP2143_13256	2.376e-116	380.0	COG1028@1|root,COG1028@2|Bacteria,1MXNY@1224|Proteobacteria,1RY5U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059,ko:K18335	ko00051,ko00061,ko00333,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,map00051,map00061,map00333,map00780,map01040,map01100,map01120,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R10690,R11671	RC00029,RC00089,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_6443800_1	1122614.JHZF01000011_gene1667	5.307e-137	455.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2PDV4@252301|Oceanicola	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_6443800_3	1187851.A33M_3709	2.805e-68	241.0	COG1024@1|root,COG1024@2|Bacteria,1PHT9@1224|Proteobacteria,2V7VX@28211|Alphaproteobacteria,3FEFZ@34008|Rhodovulum	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_6443800_4	452637.Oter_2447	4.489e-23	115.0	COG1704@1|root,COG1704@2|Bacteria	2|Bacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	GIDE,LemA
TLS2_k127_6448499_0	1313172.YM304_18820	8.46e-321	1028.0	COG1074@1|root,COG1074@2|Bacteria,2GNKH@201174|Actinobacteria,4CNQE@84992|Acidimicrobiia	84992|Acidimicrobiia	L	UvrD/REP helicase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	UvrD-helicase,UvrD_C
TLS2_k127_6448499_1	1313172.YM304_18810	6.558e-231	759.0	COG3857@1|root,COG3857@2|Bacteria,2I6QC@201174|Actinobacteria	201174|Actinobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
TLS2_k127_6448499_2	381666.H16_A0537	1.063e-49	205.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2VHVQ@28216|Betaproteobacteria,1K6VT@119060|Burkholderiaceae	28216|Betaproteobacteria	S	L,D-transpeptidase catalytic domain	ycbB	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
TLS2_k127_6451634_3	1229780.BN381_330101	5.752e-105	353.0	COG1199@1|root,COG1199@2|Bacteria,2GKT8@201174|Actinobacteria,3UW6B@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	KL	HELICc2	dinG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
TLS2_k127_6451634_2	525909.Afer_1266	4.869e-108	359.0	COG0020@1|root,COG0020@2|Bacteria,2GIXF@201174|Actinobacteria,4CN13@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS2_k127_6451634_4	1313172.YM304_24220	4.181e-79	282.0	COG1381@1|root,COG1381@2|Bacteria,2GK81@201174|Actinobacteria,4CN8K@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
TLS2_k127_6451634_0	1313172.YM304_24260	2.009e-221	692.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,4CMWI@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
TLS2_k127_6451634_7	1313172.YM304_00320	1.183e-64	230.0	2EE69@1|root,3380V@2|Bacteria,2GR09@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6451634_10	1048339.KB913029_gene4055	5.044e-11	71.0	COG3620@1|root,COG3620@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K15773	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	CBS,HTH_3,HTH_31
TLS2_k127_6451634_8	1048339.KB913029_gene1366	2.075e-40	153.0	COG4392@1|root,COG4392@2|Bacteria	2|Bacteria	E	branched-chain amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
TLS2_k127_6451634_6	1048339.KB913029_gene1365	2.184e-66	234.0	COG1296@1|root,COG1296@2|Bacteria,2GN6R@201174|Actinobacteria,4ESS4@85013|Frankiales	201174|Actinobacteria	E	AzlC protein	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
TLS2_k127_6451634_5	530564.Psta_3072	3.141e-73	266.0	COG0840@1|root,COG0840@2|Bacteria,2IXQA@203682|Planctomycetes	203682|Planctomycetes	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K02660,ko:K03406	ko02020,ko02025,ko02030,map02020,map02025,map02030	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Globin,HAMP,MCPsignal,PAS_3,PAS_4,PAS_9
TLS2_k127_6451634_1	1229780.BN381_330110	1.931e-163	534.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,3UWAA@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
TLS2_k127_6451634_9	635013.TherJR_2302	1.423e-14	84.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,260A0@186807|Peptococcaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_6458455_4	1151119.KB895506_gene305	1.071e-13	83.0	COG5549@1|root,COG5549@2|Bacteria	2|Bacteria	O	protein import	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
TLS2_k127_6458455_3	1054213.HMPREF9946_00709	4.123e-21	106.0	COG2340@1|root,COG2340@2|Bacteria,1NN0T@1224|Proteobacteria,2VFRC@28211|Alphaproteobacteria	2|Bacteria	Q	Domain of unknown function (DUF4214)	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CW_binding_2,Calx-beta,Crystall,DUF4214,HemolysinCabind,Peptidase_M10,Peptidase_M10_C
TLS2_k127_6458455_1	1380390.JIAT01000013_gene119	1.709e-97	334.0	COG2718@1|root,COG2718@2|Bacteria,2I2WH@201174|Actinobacteria,4CR4W@84995|Rubrobacteria	84995|Rubrobacteria	S	Iron-containing redox enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Haem_oxygenas_2
TLS2_k127_6458455_0	446466.Cfla_3281	1.421e-140	488.0	COG0419@1|root,COG4717@1|root,COG0419@2|Bacteria,COG4717@2|Bacteria	2|Bacteria	S	serine-type aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_27
TLS2_k127_6458455_2	446466.Cfla_3282	8.152e-73	251.0	COG0420@1|root,COG0420@2|Bacteria	2|Bacteria	L	3'-5' exonuclease activity	yhaO	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
TLS2_k127_659569_5	429009.Adeg_1336	2.844e-13	74.0	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,24GDU@186801|Clostridia,42J1U@68295|Thermoanaerobacterales	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase
TLS2_k127_659569_8	68170.KL590483_gene5665	1.289e-07	62.0	COG2172@1|root,COG2172@2|Bacteria,2IMR5@201174|Actinobacteria,4E4X0@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
TLS2_k127_659569_2	1229780.BN381_210114	1.283e-71	261.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria,3UXEG@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Ku70/Ku80 beta-barrel domain	ku	GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050790,GO:0050896,GO:0051340,GO:0051351,GO:0051716,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
TLS2_k127_659569_0	1313172.YM304_15100	7.239e-96	323.0	COG3285@1|root,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase LigD polymerase domain	ligD	GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS2_k127_659569_11	926692.AZYG01000036_gene2474	0.0004635	51.0	COG3861@1|root,COG3861@2|Bacteria,1V5RZ@1239|Firmicutes,25E5M@186801|Clostridia	186801|Clostridia	S	Heat induced stress protein YflT	-	-	-	-	-	-	-	-	-	-	-	-	YflT
TLS2_k127_659569_3	28042.GU90_10170	9.955e-54	201.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4DYMB@85010|Pseudonocardiales	201174|Actinobacteria	K	RNA polymerase sigma factor, sigma-70 family	sigF	GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_659569_7	656024.FsymDg_0981	4.491e-09	63.0	COG2172@1|root,COG2172@2|Bacteria,2IFG9@201174|Actinobacteria,4ETEG@85013|Frankiales	201174|Actinobacteria	T	anti-sigma regulatory factor	rsbW	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036094,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
TLS2_k127_659569_10	1246995.AFR_03840	0.0001056	49.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749,ko:K17763	-	-	-	-	ko00000,ko03021	-	-	-	PAS_4,STAS,STAS_2
TLS2_k127_659569_4	641491.DND132_3238	7.049e-52	208.0	COG5001@1|root,COG5001@2|Bacteria,1QZC1@1224|Proteobacteria	1224|Proteobacteria	T	diguanylate cyclase	-	-	2.7.7.65	ko:K21088	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF
TLS2_k127_659569_1	1380354.JIAN01000005_gene1931	4.312e-74	265.0	COG0715@1|root,COG0715@2|Bacteria,2I95I@201174|Actinobacteria	201174|Actinobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6599681_5	441620.Mpop_0167	3.544e-31	128.0	COG3920@1|root,COG3920@2|Bacteria,1QYBH@1224|Proteobacteria,2U82C@28211|Alphaproteobacteria,1JSP0@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS_9
TLS2_k127_6599681_4	58123.JOFJ01000013_gene4868	3.155e-48	187.0	COG2203@1|root,COG2203@2|Bacteria,2HGVH@201174|Actinobacteria,4EJDR@85012|Streptosporangiales	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS2_k127_6599681_2	1313172.YM304_22190	1.358e-108	373.0	COG0038@1|root,COG0038@2|Bacteria,2HGV9@201174|Actinobacteria,4CNW2@84992|Acidimicrobiia	84992|Acidimicrobiia	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	Voltage_CLC
TLS2_k127_6599681_1	1229780.BN381_150040	8.258e-137	458.0	COG2812@1|root,COG2812@2|Bacteria,2GJKA@201174|Actinobacteria,3UWAK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
TLS2_k127_6599681_6	1370121.AUWS01000057_gene3667	9.552e-19	92.0	COG0718@1|root,COG0718@2|Bacteria,2IRC4@201174|Actinobacteria,23A0U@1762|Mycobacteriaceae	201174|Actinobacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
TLS2_k127_6599681_3	1313172.YM304_37150	2.049e-90	303.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4CN1B@84992|Acidimicrobiia	84992|Acidimicrobiia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
TLS2_k127_6599681_0	1229780.BN381_150043	5.454e-163	520.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,3UWCM@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Thiolase, C-terminal domain	fadA4	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0044464,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0075136,GO:1901575	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_6602154_2	1313172.YM304_37400	5.83e-113	374.0	COG0142@1|root,COG0142@2|Bacteria,2GJEK@201174|Actinobacteria,4CMXY@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_6602154_6	1313172.YM304_37380	2.573e-09	64.0	COG1722@1|root,COG1722@2|Bacteria,2HD2Z@201174|Actinobacteria	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	-	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
TLS2_k127_6602154_3	1313172.YM304_37370	1.16e-70	269.0	COG1570@1|root,COG1570@2|Bacteria,2GJAS@201174|Actinobacteria,4CNA1@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TLS2_k127_6602154_1	1123368.AUIS01000004_gene115	2.331e-114	398.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales	225057|Acidithiobacillales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_4,Response_reg
TLS2_k127_6602154_0	745014.OMB55_00020740	5.403e-119	397.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1RRTD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_6602154_4	1408254.T458_25970	7.785e-48	178.0	COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,4HH7S@91061|Bacilli,26WR2@186822|Paenibacillaceae	91061|Bacilli	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
TLS2_k127_6602154_5	1463841.JOIR01000022_gene3198	1.06e-32	136.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2GK8P@201174|Actinobacteria	201174|Actinobacteria	T	protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c_2,PAS_4,PAS_9,SpoIIE,sCache_3_2
TLS2_k127_660523_1	1048339.KB913029_gene2528	1.452e-167	563.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4ERZ6@85013|Frankiales	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_660523_6	105422.BBPM01000026_gene4078	4.581e-108	356.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,2NGR6@228398|Streptacidiphilus	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_660523_15	1122622.ATWJ01000011_gene2141	2.676e-34	138.0	2AWFS@1|root,31NC1@2|Bacteria,2IMS0@201174|Actinobacteria,4FH76@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_660523_3	290399.Arth_3961	3.682e-125	418.0	COG3064@1|root,COG3064@2|Bacteria,2I5UC@201174|Actinobacteria	201174|Actinobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
TLS2_k127_660523_20	1449048.JQKU01000023_gene2644	7.147e-17	90.0	COG0664@1|root,COG1670@1|root,COG0664@2|Bacteria,COG1670@2|Bacteria,2HNCU@201174|Actinobacteria,234EN@1762|Mycobacteriaceae	201174|Actinobacteria	JT	cyclic nucleotide-binding	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0030551,GO:0030552,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,cNMP_binding
TLS2_k127_660523_12	1068978.AMETH_2110	2.113e-54	203.0	COG2755@1|root,COG2755@2|Bacteria,2IFV1@201174|Actinobacteria	201174|Actinobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS2_k127_660523_10	710696.Intca_0371	2.133e-79	269.0	COG1765@1|root,COG1765@2|Bacteria,2IG8A@201174|Actinobacteria,4FJTH@85021|Intrasporangiaceae	201174|Actinobacteria	O	redox protein regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_660523_9	710696.Intca_0370	7.581e-93	321.0	COG0644@1|root,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria,4FFUZ@85021|Intrasporangiaceae	201174|Actinobacteria	C	FAD binding domain	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
TLS2_k127_660523_13	1298863.AUEP01000011_gene623	8.557e-51	184.0	COG2030@1|root,COG2030@2|Bacteria,2IK2Z@201174|Actinobacteria	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS2_k127_660523_21	298655.KI912266_gene5186	1.077e-16	86.0	COG1017@1|root,COG1017@2|Bacteria,2GKXT@201174|Actinobacteria,4ERZU@85013|Frankiales	201174|Actinobacteria	C	Belongs to the globin family	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Globin,NAD_binding_1
TLS2_k127_660523_8	298655.KI912266_gene2210	1.922e-94	342.0	COG2909@1|root,COG2909@2|Bacteria,2GM03@201174|Actinobacteria,4ETTY@85013|Frankiales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_660523_17	710696.Intca_0369	1.621e-30	141.0	COG0596@1|root,COG1506@1|root,COG3710@1|root,COG0596@2|Bacteria,COG1506@2|Bacteria,COG3710@2|Bacteria,2HASC@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS2_k127_660523_19	1132509.C447_01400	4.158e-24	112.0	COG1296@1|root,arCOG04452@2157|Archaea,2XWP8@28890|Euryarchaeota,23VF2@183963|Halobacteria	183963|Halobacteria	E	branched-chain amino acid permease (azaleucine resistance)	azlC	-	-	-	-	-	-	-	-	-	-	-	AzlC
TLS2_k127_660523_11	2074.JNYD01000023_gene1340	4.565e-61	225.0	COG2120@1|root,COG2120@2|Bacteria,2IDT2@201174|Actinobacteria,4EBAF@85010|Pseudonocardiales	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K22135	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_660523_7	1248916.ANFY01000006_gene1956	2.297e-107	375.0	COG3349@1|root,COG3349@2|Bacteria,1N0QS@1224|Proteobacteria,2U39T@28211|Alphaproteobacteria,2K9HY@204457|Sphingomonadales	204457|Sphingomonadales	S	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
TLS2_k127_660523_18	1121939.L861_11945	1.707e-26	129.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
TLS2_k127_660523_24	504832.OCAR_4624	4.19e-07	63.0	COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2TSY5@28211|Alphaproteobacteria,3JWP1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA_3,PAS_4,PAS_9,PHY,Response_reg
TLS2_k127_660523_23	1278078.G419_24642	5.671e-10	68.0	COG1309@1|root,COG1309@2|Bacteria,2GVM5@201174|Actinobacteria,4FV7I@85025|Nocardiaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_660523_22	68170.KL590474_gene6024	1.181e-12	74.0	2DQ4Z@1|root,334SM@2|Bacteria,2GWJC@201174|Actinobacteria,4E7K9@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF2568)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2568
TLS2_k127_660523_2	1123023.JIAI01000003_gene2847	1.282e-132	440.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4E9YT@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_660523_0	1313172.YM304_31890	8.386e-288	904.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4CMX3@84992|Acidimicrobiia	84992|Acidimicrobiia	P	E1-E2 ATPase	copA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K12956	-	-	R00086	RC00002	ko00000,ko01000	3.A.3,3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS2_k127_660523_16	1206720.BAFQ01000038_gene875	3.685e-33	130.0	COG1937@1|root,COG1937@2|Bacteria,2IQAC@201174|Actinobacteria,4G218@85025|Nocardiaceae	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
TLS2_k127_660523_14	656024.FsymDg_4400	2.99e-47	180.0	COG0463@1|root,COG2246@1|root,COG0463@2|Bacteria,COG2246@2|Bacteria,2I4BA@201174|Actinobacteria,4EXHK@85013|Frankiales	201174|Actinobacteria	M	glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
TLS2_k127_660523_4	1068978.AMETH_0140	4.995e-110	371.0	COG0683@1|root,COG0683@2|Bacteria,2GMCF@201174|Actinobacteria,4E14S@85010|Pseudonocardiales	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
TLS2_k127_660523_5	1068978.AMETH_0141	9.478e-110	364.0	COG4177@1|root,COG4177@2|Bacteria,2GMGD@201174|Actinobacteria,4DYYG@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_662569_6	1229780.BN381_300008	2.06e-31	124.0	COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_662569_7	405948.SACE_3654	1.805e-28	117.0	COG1846@1|root,COG1846@2|Bacteria,2IMGG@201174|Actinobacteria,4ECQ0@85010|Pseudonocardiales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_24,MarR_2
TLS2_k127_662569_1	1122221.JHVI01000015_gene1707	1.193e-94	319.0	COG3329@1|root,COG3329@2|Bacteria,1WJER@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Na+-dependent bicarbonate transporter superfamily	-	-	-	ko:K07086	-	-	-	-	ko00000	-	-	-	Sbt_1
TLS2_k127_662569_5	525379.HMPREF0819_1268	5.884e-34	150.0	COG0288@1|root,COG0288@2|Bacteria,1V0TA@1239|Firmicutes,4HB9V@91061|Bacilli	91061|Bacilli	P	Reversible hydration of carbon dioxide	cah	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS2_k127_662569_0	390989.JOEG01000004_gene3785	1.695e-95	322.0	COG1893@1|root,COG1893@2|Bacteria,2GP6K@201174|Actinobacteria,4D9HN@85008|Micromonosporales	201174|Actinobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
TLS2_k127_662569_8	1122939.ATUD01000001_gene410	1.192e-05	52.0	2B8TX@1|root,32240@2|Bacteria,2HRST@201174|Actinobacteria,4CTW1@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_662569_3	479435.Kfla_5998	1.205e-49	183.0	COG0030@1|root,COG0030@2|Bacteria,2IMS8@201174|Actinobacteria,4DWR1@85009|Propionibacteriales	201174|Actinobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family	-	-	2.1.1.184	ko:K00561	-	-	R10716	RC00003,RC03257	br01600,ko00000,ko01000,ko01504,ko03009	-	-	-	RrnaAD
TLS2_k127_662569_4	35754.JNYJ01000101_gene9932	8.531e-42	159.0	COG2323@1|root,COG2323@2|Bacteria,2IMTN@201174|Actinobacteria,4DIQV@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
TLS2_k127_662569_2	1313172.YM304_03730	2.605e-51	188.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_6650982_8	929712.KI912613_gene4125	9.117e-94	317.0	COG2141@1|root,COG2141@2|Bacteria,2ID60@201174|Actinobacteria,4CTIG@84995|Rubrobacteria	84995|Rubrobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_6650982_12	1121877.JQKF01000003_gene1502	5.308e-81	276.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria,4CN01@84992|Acidimicrobiia	84992|Acidimicrobiia	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TLS2_k127_6650982_23	285514.JNWO01000002_gene5386	3.45e-16	86.0	COG1595@1|root,COG1595@2|Bacteria,2ID45@201174|Actinobacteria	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6650982_0	1229780.BN381_210057	1.957e-247	780.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,3UX9W@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1,1.3.8.12	ko:K00248,ko:K14448	ko00071,ko00280,ko00630,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00630,map00650,map01100,map01110,map01120,map01200,map01212	M00373	R01175,R01178,R02661,R03172,R04751,R09293	RC00052,RC00068,RC00076,RC00120,RC00148,RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_6650982_4	1500897.JQNA01000002_gene4645	1.414e-117	411.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K0RA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,HAMP,PAS,PAS_4,PAS_8,PAS_9,dCache_3
TLS2_k127_6650982_11	1313172.YM304_14250	8.819e-83	284.0	COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4CMYB@84992|Acidimicrobiia	84992|Acidimicrobiia	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS2_k127_6650982_9	1313172.YM304_14260	1.611e-93	316.0	COG1194@1|root,COG1194@2|Bacteria,2GJD9@201174|Actinobacteria,4CNWS@84992|Acidimicrobiia	84992|Acidimicrobiia	L	endonuclease III	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TLS2_k127_6650982_7	1313172.YM304_14690	5.415e-100	333.0	COG2267@1|root,COG2267@2|Bacteria,2I3E8@201174|Actinobacteria	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_6650982_10	1313172.YM304_14700	1.379e-86	295.0	COG1235@1|root,COG1235@2|Bacteria,2IJCH@201174|Actinobacteria	201174|Actinobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_6650982_19	279238.Saro_1462	1.901e-48	178.0	COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,2UCHI@28211|Alphaproteobacteria,2K4VD@204457|Sphingomonadales	204457|Sphingomonadales	K	DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TLS2_k127_6650982_15	656024.FsymDg_1805	2.285e-67	233.0	COG0663@1|root,COG0663@2|Bacteria,2GP22@201174|Actinobacteria,4EVCG@85013|Frankiales	201174|Actinobacteria	S	Bacterial transferase hexapeptide (six repeats)	gca	-	-	ko:K02617	-	-	-	-	ko00000	-	-	-	Hexapep
TLS2_k127_6650982_17	298653.Franean1_0671	3.476e-66	232.0	COG3145@1|root,COG3145@2|Bacteria,2GNBD@201174|Actinobacteria	201174|Actinobacteria	L	DNA repair protein	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
TLS2_k127_6650982_6	1160718.SU9_06875	3.023e-102	345.0	COG2141@1|root,COG2141@2|Bacteria,2GJTP@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_6650982_2	1313172.YM304_29210	2.541e-200	641.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CNI7@84992|Acidimicrobiia	84992|Acidimicrobiia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_6650982_5	345341.KUTG_08193	1.46e-117	419.0	COG2274@1|root,COG2274@2|Bacteria,2I2QC@201174|Actinobacteria,4EE39@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran,Peptidase_C39
TLS2_k127_6650982_21	1206733.BAGC01000114_gene7273	1.145e-42	173.0	COG2199@1|root,COG2199@2|Bacteria,2IJ6M@201174|Actinobacteria,4FXMF@85025|Nocardiaceae	201174|Actinobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF,PAS,PAS_4
TLS2_k127_6650982_1	1121877.JQKF01000001_gene1306	8.871e-243	759.0	COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria,4CMQU@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TLS2_k127_6650982_20	1229780.BN381_210073	3.854e-43	162.0	2FF8Q@1|root,3476J@2|Bacteria,2H7PN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6650982_16	525904.Tter_1697	5.651e-67	244.0	COG0719@1|root,COG0719@2|Bacteria,2NPGC@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufD	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0040007,GO:0043207,GO:0044085,GO:0044237,GO:0044403,GO:0044419,GO:0050896,GO:0051186,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071840,GO:0075136	-	ko:K07033,ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
TLS2_k127_6650982_22	1449353.JQMQ01000005_gene1612	1.151e-20	106.0	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,2NJ4Y@228398|Streptacidiphilus	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	hcaC	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
TLS2_k127_6650982_14	477641.MODMU_3609	1.173e-73	257.0	COG0396@1|root,COG0396@2|Bacteria,2GKB7@201174|Actinobacteria,4ES3Z@85013|Frankiales	201174|Actinobacteria	O	TIGRFAM FeS assembly ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
TLS2_k127_6650982_13	640081.Dsui_2148	1.883e-74	276.0	COG4564@1|root,COG5001@1|root,COG4564@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KW14@206389|Rhodocyclales	206389|Rhodocyclales	T	Cache 3/Cache 2 fusion domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9,dCache_2
TLS2_k127_6650982_24	526225.Gobs_4669	4.342e-09	63.0	2C3UR@1|root,330BB@2|Bacteria,2GU03@201174|Actinobacteria,4EWJB@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6650982_18	1229780.BN381_210086	8.062e-60	213.0	COG0822@1|root,COG0822@2|Bacteria,2IHY9@201174|Actinobacteria,3UWVS@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NifU-like N terminal domain	sufU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS2_k127_6650982_3	1229780.BN381_210087	1.147e-169	543.0	COG0520@1|root,COG0520@2|Bacteria,2GIVK@201174|Actinobacteria,3UWF9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Aminotransferase class-V	sufS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
TLS2_k127_667090_3	1122182.KB903836_gene4744	2.049e-132	433.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,4D8G1@85008|Micromonosporales	201174|Actinobacteria	L	helicase	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
TLS2_k127_667090_11	1121877.JQKF01000002_gene1628	2.165e-59	218.0	COG0805@1|root,COG0805@2|Bacteria,2GJK8@201174|Actinobacteria,4CN3F@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
TLS2_k127_667090_16	563192.HMPREF0179_03491	2.94e-07	55.0	COG1826@1|root,COG1826@2|Bacteria,1NI3F@1224|Proteobacteria,42VIZ@68525|delta/epsilon subdivisions,2WRC5@28221|Deltaproteobacteria,2MDCV@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatB	-	-	ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS2_k127_667090_7	1313172.YM304_26000	1.529e-73	255.0	COG0584@1|root,COG0584@2|Bacteria	2|Bacteria	C	glycerophosphodiester phosphodiesterase activity	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS2_k127_667090_13	1283283.ATXA01000001_gene843	6.9e-35	143.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4ESKU@85013|Frankiales	201174|Actinobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS2_k127_667090_12	1229780.BN381_400037	1.812e-43	166.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,3UWRN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS2_k127_667090_8	1229780.BN381_400038	7.898e-72	265.0	COG2378@1|root,COG2378@2|Bacteria,2GMAU@201174|Actinobacteria,3UWZY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	WYL domain	pafC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
TLS2_k127_667090_9	1229780.BN381_400039	3.24e-63	234.0	COG2378@1|root,COG2378@2|Bacteria,2GM46@201174|Actinobacteria,3UWZ5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	WYL domain	pafB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K13572,ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
TLS2_k127_667090_5	1229780.BN381_400040	3.055e-108	361.0	COG3502@1|root,COG3502@2|Bacteria,2H2JJ@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3866)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3866
TLS2_k127_667090_1	1313172.YM304_26020	1.989e-255	791.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4CMS0@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	-	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
TLS2_k127_667090_6	1229780.BN381_400042	5.969e-83	294.0	COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,3UX82@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	Proteasome subunit	prcA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
TLS2_k127_667090_4	1229780.BN381_400043	1.009e-116	381.0	COG0638@1|root,COG0638@2|Bacteria,2GJ60@201174|Actinobacteria,3UX89@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	Proteasome subunit	prcB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
TLS2_k127_667090_14	1313172.YM304_26060	2.259e-18	86.0	2E9C2@1|root,333JS@2|Bacteria,2HGHP@201174|Actinobacteria,4CNEV@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation	pup	-	-	ko:K13570	-	-	-	-	ko00000,ko04121	-	-	-	Pup
TLS2_k127_667090_2	1313172.YM304_26070	1.327e-197	627.0	COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,4CMSZ@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Pup-ligase protein	dop	-	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
TLS2_k127_667090_10	1343740.M271_42610	4.858e-61	222.0	COG0412@1|root,COG0412@2|Bacteria,2H3SA@201174|Actinobacteria	201174|Actinobacteria	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS2_k127_667090_0	1229780.BN381_410004	7.192e-267	835.0	COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,3UX32@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	Proteasomal ATPase OB/ID domain	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
TLS2_k127_6675878_4	316055.RPE_1103	1.966e-90	328.0	COG0438@1|root,COG0438@2|Bacteria,1MX12@1224|Proteobacteria,2U2QK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_6675878_14	1382359.JIAL01000001_gene847	6.007e-23	115.0	COG3307@1|root,COG3307@2|Bacteria,3Y5Q6@57723|Acidobacteria,2JK0G@204432|Acidobacteriia	204432|Acidobacteriia	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TLS2_k127_6675878_11	1120948.KB903221_gene392	7.776e-55	215.0	COG1215@1|root,COG1215@2|Bacteria,2GJP7@201174|Actinobacteria,4E63X@85010|Pseudonocardiales	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_6675878_10	1487953.JMKF01000045_gene2789	9.617e-58	222.0	COG0451@1|root,COG0451@2|Bacteria,1G2TN@1117|Cyanobacteria,1HEZM@1150|Oscillatoriales	1117|Cyanobacteria	GM	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_6675878_8	65393.PCC7424_5288	3.176e-70	264.0	COG0673@1|root,COG0673@2|Bacteria,1G37N@1117|Cyanobacteria	1117|Cyanobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_6675878_13	864051.BurJ1DRAFT_1277	2.755e-26	121.0	COG0463@1|root,COG0463@2|Bacteria,1QU5I@1224|Proteobacteria,2WF3P@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Pfam Glycosyl transferase family 2	-	-	-	ko:K16556	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	-	Glycos_transf_2
TLS2_k127_6675878_6	1090318.ATTI01000001_gene2424	7.305e-76	268.0	2DKYJ@1|root,30WNV@2|Bacteria,1R18V@1224|Proteobacteria,2UE8N@28211|Alphaproteobacteria,2KC85@204457|Sphingomonadales	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1996)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1996
TLS2_k127_6675878_9	1122182.KB903839_gene1177	4.624e-66	239.0	COG0673@1|root,COG0673@2|Bacteria,2HVJV@201174|Actinobacteria,4DHBJ@85008|Micromonosporales	201174|Actinobacteria	S	Semialdehyde dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_6675878_16	1449069.JMLO01000017_gene3331	1.805e-19	104.0	2C825@1|root,32RK8@2|Bacteria,2IGR2@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_6675878_12	1040986.ATYO01000006_gene448	3.705e-28	130.0	COG1215@1|root,COG1215@2|Bacteria,1R66B@1224|Proteobacteria,2U968@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_6675878_2	1463825.JNXC01000007_gene777	7.829e-105	369.0	COG0381@1|root,COG0381@2|Bacteria,2GJWS@201174|Actinobacteria,4E0BY@85010|Pseudonocardiales	201174|Actinobacteria	G	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
TLS2_k127_6675878_1	1122182.KB903839_gene1176	3.733e-131	436.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4DBF6@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.33	ko:K21328	ko00523,ko01130,map00523,map01130	-	R02773,R11475	RC00006,RC00781,RC01514	ko00000,ko00001,ko01000	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_6675878_7	526225.Gobs_4289	2.328e-70	249.0	COG0110@1|root,COG0110@2|Bacteria,2H5M0@201174|Actinobacteria,4ESP6@85013|Frankiales	201174|Actinobacteria	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	FdtA,Hexapep,Hexapep_2
TLS2_k127_6675878_0	530564.Psta_1439	2.72e-140	459.0	COG1232@1|root,COG1232@2|Bacteria,2IX1A@203682|Planctomycetes	203682|Planctomycetes	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS2_k127_6675878_3	1142394.PSMK_18700	5.378e-103	363.0	COG0726@1|root,COG0726@2|Bacteria,2IXA4@203682|Planctomycetes	203682|Planctomycetes	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_6675878_5	1173029.JH980292_gene2483	9.835e-80	287.0	COG1215@1|root,COG1215@2|Bacteria,1G3TI@1117|Cyanobacteria,1HAHR@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_6675878_15	760117.JN27_21195	4.666e-21	94.0	COG1922@1|root,COG1922@2|Bacteria,1N1HD@1224|Proteobacteria,2VPIW@28216|Betaproteobacteria,472EY@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Belongs to the glycosyltransferase 26 family	-	-	2.4.1.187	ko:K05946,ko:K13660	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB,STAS_2
TLS2_k127_6688161_15	292459.STH2430	1.561e-21	95.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia	186801|Clostridia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
TLS2_k127_6688161_2	656024.FsymDg_2934	7.963e-165	534.0	COG0488@1|root,COG0488@2|Bacteria,2GK9S@201174|Actinobacteria,4ETZI@85013|Frankiales	201174|Actinobacteria	S	ATPase component of ABC transporters with duplicated ATPase domain	yjjK	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_6688161_11	1313172.YM304_11470	3.997e-42	162.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6688161_1	1229780.BN381_150118	3.199e-173	556.0	COG0438@1|root,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria,3UX6F@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_6688161_7	469371.Tbis_2874	3.444e-88	316.0	COG0500@1|root,COG2226@2|Bacteria,2H38T@201174|Actinobacteria,4DZB1@85010|Pseudonocardiales	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_6688161_3	1229780.BN381_150116	2.615e-135	440.0	COG3387@1|root,COG3387@2|Bacteria,2GKU7@201174|Actinobacteria,3UX92@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
TLS2_k127_6688161_8	1229780.BN381_150114	2.951e-87	295.0	COG4122@1|root,COG4122@2|Bacteria,2GQ0Z@201174|Actinobacteria,3UXB0@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
TLS2_k127_6688161_16	525909.Afer_1833	1.952e-20	98.0	COG2246@1|root,COG2246@2|Bacteria,2HGRJ@201174|Actinobacteria,4CNUB@84992|Acidimicrobiia	84992|Acidimicrobiia	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
TLS2_k127_6688161_4	1121877.JQKF01000003_gene1564	1.868e-109	362.0	COG1946@1|root,COG1946@2|Bacteria,2GJ1B@201174|Actinobacteria,4CMRR@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Thioesterase-like superfamily	-	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
TLS2_k127_6688161_6	1137269.AZWL01000001_gene5561	7.586e-93	331.0	COG2133@1|root,COG2133@2|Bacteria,2I9ZW@201174|Actinobacteria	201174|Actinobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,GSDH
TLS2_k127_6688161_12	479431.Namu_2243	1.129e-34	139.0	COG3502@1|root,COG3502@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF952)	-	-	2.3.2.29,2.5.1.18,3.8.1.2	ko:K00799,ko:K01560,ko:K21420	ko00361,ko00480,ko00625,ko00980,ko00982,ko00983,ko01100,ko01120,ko01524,ko05200,ko05204,ko05225,ko05418,map00361,map00480,map00625,map00980,map00982,map00983,map01100,map01120,map01524,map05200,map05204,map05225,map05418	-	R03522,R05287,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11547,R11548,R11905	RC00004,RC00064,RC00069,RC00697,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	DUF952,GST_C_2,GST_N_3
TLS2_k127_6688161_5	298653.Franean1_7087	4.866e-109	360.0	COG2141@1|root,COG2141@2|Bacteria,2GMRE@201174|Actinobacteria,4EU7W@85013|Frankiales	201174|Actinobacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_6688161_9	1313172.YM304_09390	2.638e-60	220.0	COG3871@1|root,COG3871@2|Bacteria,2IFC3@201174|Actinobacteria	201174|Actinobacteria	S	stress protein (general stress protein 26)	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_6688161_10	446470.Snas_6347	1.01e-47	177.0	COG0346@1|root,COG0346@2|Bacteria,2IM78@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6688161_13	356851.JOAN01000016_gene6065	6.627e-34	134.0	COG2315@1|root,COG2315@2|Bacteria,2ISFT@201174|Actinobacteria,4DEX8@85008|Micromonosporales	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
TLS2_k127_6688161_0	1313172.YM304_03730	9.05e-185	581.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_669702_6	446466.Cfla_2256	3.084e-06	59.0	COG0823@1|root,COG0823@2|Bacteria,2GMNT@201174|Actinobacteria	201174|Actinobacteria	U	Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,PD40
TLS2_k127_669702_3	1313172.YM304_25490	2.181e-76	261.0	COG1853@1|root,COG1853@2|Bacteria	2|Bacteria	S	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TLS2_k127_669702_2	1313172.YM304_28950	4.916e-80	278.0	COG0560@1|root,COG0560@2|Bacteria,2H4ZQ@201174|Actinobacteria	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	-	-	2.7.1.39,3.1.3.3	ko:K02203	ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230	M00018	R00582,R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD
TLS2_k127_669702_4	479434.Sthe_0109	3.033e-47	192.0	COG0412@1|root,COG0412@2|Bacteria,2G8NW@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TLS2_k127_669702_0	1211815.CBYP010000019_gene2878	2.603e-144	481.0	COG2124@1|root,COG2124@2|Bacteria,2HSPE@201174|Actinobacteria,4EV1U@85013|Frankiales	201174|Actinobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_669702_5	1313172.YM304_36260	2.485e-13	81.0	COG1141@1|root,COG1141@2|Bacteria,2GWHY@201174|Actinobacteria	201174|Actinobacteria	C	Ferredoxin	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13,Fer4_15
TLS2_k127_669702_1	1173025.GEI7407_1132	3.745e-123	427.0	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7V4@1150|Oscillatoriales	1117|Cyanobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,PAS_9
TLS2_k127_6721244_19	1266998.ATUJ01000004_gene1268	1.162e-47	193.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,2PW79@265|Paracoccus	28211|Alphaproteobacteria	I	functions in conversion of succinate to propionate	bhbA	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
TLS2_k127_6721244_0	1313172.YM304_28810	3.004e-195	617.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4CMT7@84992|Acidimicrobiia	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_6721244_23	33876.JNXY01000030_gene2834	2.054e-26	120.0	COG2852@1|root,COG2852@2|Bacteria,2GSDS@201174|Actinobacteria,4DMGJ@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF559)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	AbiEi_4,DUF559
TLS2_k127_6721244_1	1455608.JDTH01000002_gene604	5.751e-181	584.0	COG4770@1|root,arCOG01591@2157|Archaea,2XTDR@28890|Euryarchaeota,23S0G@183963|Halobacteria	183963|Halobacteria	I	COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit	pccA	GO:0003674,GO:0003824,GO:0004658,GO:0016421,GO:0016874,GO:0016885	6.3.4.14,6.4.1.2,6.4.1.3	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
TLS2_k127_6721244_20	2074.JNYD01000012_gene443	1.317e-45	175.0	COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria,4E356@85010|Pseudonocardiales	201174|Actinobacteria	H	biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
TLS2_k127_6721244_4	1123251.ATWM01000003_gene1308	2.067e-140	475.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4FFJC@85021|Intrasporangiaceae	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_6721244_6	1394178.AWOO02000001_gene1262	4.496e-134	447.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4EM4F@85012|Streptosporangiales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_6721244_12	1463879.JOHP01000054_gene6846	7.083e-97	325.0	COG0115@1|root,COG0115@2|Bacteria,2GN5Z@201174|Actinobacteria	201174|Actinobacteria	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS2_k127_6721244_18	1229780.BN381_310079	4.063e-66	246.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria,3UXS8@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	yvhJ	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
TLS2_k127_6721244_3	1229780.BN381_10176	5.478e-167	536.0	COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria,3UW6R@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	UDP binding domain	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS2_k127_6721244_7	926550.CLDAP_15490	2.004e-133	435.0	COG0451@1|root,COG0451@2|Bacteria,2G64F@200795|Chloroflexi	200795|Chloroflexi	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_6721244_21	309807.SRU_0620	1.191e-40	170.0	COG0438@1|root,COG0438@2|Bacteria,4NKNS@976|Bacteroidetes,1FK33@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_6721244_5	575540.Isop_1615	8.341e-135	438.0	COG0451@1|root,COG0451@2|Bacteria,2IYPU@203682|Planctomycetes	203682|Planctomycetes	M	Male sterility protein	-	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	Epimerase
TLS2_k127_6721244_10	351607.Acel_0448	1.585e-101	345.0	COG0438@1|root,COG0438@2|Bacteria,2GMEW@201174|Actinobacteria,4EU38@85013|Frankiales	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_6721244_13	365528.KB891219_gene1134	6.742e-85	301.0	COG0438@1|root,COG0438@2|Bacteria,2IJX1@201174|Actinobacteria,4EV7B@85013|Frankiales	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_6721244_11	1229780.BN381_10183	2.925e-98	331.0	COG1208@1|root,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,3UXFW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	JM	Nucleotidyl transferase	manC	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
TLS2_k127_6721244_17	1313172.YM304_28620	1.18e-76	273.0	COG0451@1|root,COG0451@2|Bacteria,2I2UT@201174|Actinobacteria,4CN6I@84992|Acidimicrobiia	84992|Acidimicrobiia	GM	GDP-mannose 4,6 dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS2_k127_6721244_14	1229780.BN381_10186	1.718e-84	291.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,3UXCJ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	F420-0:Gamma-glutamyl ligase	fbiB	GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase,Nitroreductase
TLS2_k127_6721244_8	1313172.YM304_28610	2.437e-105	350.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria,4CN0F@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Uncharacterised protein family UPF0052	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
TLS2_k127_6721244_2	1128421.JAGA01000003_gene3003	2.974e-171	541.0	COG1089@1|root,COG1089@2|Bacteria,2NNM2@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_6721244_22	867845.KI911784_gene1523	1.059e-31	131.0	COG1476@1|root,COG1476@2|Bacteria,2GB72@200795|Chloroflexi,377H5@32061|Chloroflexia	32061|Chloroflexia	K	Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6721244_9	1229780.BN381_10190	1.391e-104	348.0	COG1089@1|root,COG1089@2|Bacteria,2GNMA@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	-	-	1.1.1.281	ko:K15856	ko00051,ko00520,map00051,map00520	-	R03397,R03399	RC00182	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_6721244_15	525909.Afer_0742	2.494e-80	284.0	COG0438@1|root,COG0438@2|Bacteria,2GIVP@201174|Actinobacteria,4CN35@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_6721244_16	1229780.BN381_10192	1.313e-78	274.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,3UWUN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
TLS2_k127_6731515_10	469383.Cwoe_3159	9.236e-38	149.0	COG2050@1|root,COG2050@2|Bacteria,2HMKZ@201174|Actinobacteria,4CSHW@84995|Rubrobacteria	84995|Rubrobacteria	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
TLS2_k127_6731515_7	1172179.AUKV01000056_gene7950	2.125e-53	192.0	COG0748@1|root,COG0748@2|Bacteria,2I36B@201174|Actinobacteria	201174|Actinobacteria	P	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_6731515_6	58123.JOFJ01000029_gene1110	1.804e-62	232.0	COG5001@1|root,COG5001@2|Bacteria	2|Bacteria	T	cyclic-guanylate-specific phosphodiesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_8
TLS2_k127_6731515_8	1128427.KB904821_gene3596	9.881e-48	183.0	COG0705@1|root,COG0705@2|Bacteria,1G5DT@1117|Cyanobacteria,1H961@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS2_k127_6731515_0	1304865.JAGF01000001_gene2394	0.0	1021.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria	201174|Actinobacteria	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
TLS2_k127_6731515_5	35754.JNYJ01000008_gene3159	8.733e-78	277.0	COG0614@1|root,COG0614@2|Bacteria,2GM6R@201174|Actinobacteria,4D9QG@85008|Micromonosporales	201174|Actinobacteria	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS2_k127_6731515_11	1137269.AZWL01000055_gene1292	1.924e-35	146.0	2DBMF@1|root,2Z9YG@2|Bacteria,2I871@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6731515_9	1122609.AUGT01000003_gene2452	3.522e-45	173.0	COG3132@1|root,COG4106@1|root,COG3132@2|Bacteria,COG4106@2|Bacteria,2I5BV@201174|Actinobacteria,4DRTB@85009|Propionibacteriales	201174|Actinobacteria	E	Protein of unknown function, DUF480	-	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480,Methyltransf_25
TLS2_k127_6731515_3	580340.Tlie_1327	2.844e-140	470.0	COG0018@1|root,COG0018@2|Bacteria,3TA5K@508458|Synergistetes	508458|Synergistetes	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
TLS2_k127_6731515_1	391625.PPSIR1_06983	2.929e-177	578.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2YUK3@29|Myxococcales	28221|Deltaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS2_k127_6731515_2	1229780.BN381_10012	9.82e-163	541.0	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,3UWE2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Homoserine dehydrogenase	hom	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294	ACT,Homoserine_dh,NAD_binding_3
TLS2_k127_6731515_4	1177928.TH2_04433	3.519e-110	372.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2TT0D@28211|Alphaproteobacteria,2JPG8@204441|Rhodospirillales	204441|Rhodospirillales	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
TLS2_k127_6743257_14	1313172.YM304_09940	5.364e-16	80.0	2EN76@1|root,33FV1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6743257_13	1385518.N798_07535	6.012e-31	133.0	2E3QV@1|root,32YNP@2|Bacteria,2GQQZ@201174|Actinobacteria,4FHE0@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905
TLS2_k127_6743257_4	1282876.BAOK01000001_gene980	1.573e-106	355.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,4BQDS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
TLS2_k127_6743257_3	1229780.BN381_40047	1.54e-123	406.0	COG0604@1|root,COG0604@2|Bacteria,2I66C@201174|Actinobacteria	201174|Actinobacteria	C	Protein of unknown function (DUF2855)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2855
TLS2_k127_6743257_6	1133849.O3I_013415	2.765e-75	254.0	COG3832@1|root,COG3832@2|Bacteria,2I45V@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_6743257_0	1211815.CBYP010000016_gene2641	9.872e-200	645.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,NB-ARC,Response_reg,TIR_2,TPR_10,TPR_12
TLS2_k127_6743257_10	382464.ABSI01000013_gene1533	4.592e-47	179.0	2E4PM@1|root,32P93@2|Bacteria,46W56@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6743257_5	1380356.JNIK01000001_gene2071	4.66e-85	289.0	COG0426@1|root,COG0426@2|Bacteria,2GKJ9@201174|Actinobacteria,4ESHY@85013|Frankiales	201174|Actinobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6743257_9	1448389.BAVQ01000002_gene2867	2.993e-47	177.0	COG1309@1|root,COG1309@2|Bacteria,2IMHK@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_6743257_11	1313172.YM304_33680	2.883e-44	166.0	COG0490@1|root,COG0490@2|Bacteria,2IFBQ@201174|Actinobacteria	201174|Actinobacteria	P	regulatory, ligand-binding protein related to C-terminal domains of K channels	-	-	-	ko:K07228	-	-	-	-	ko00000	-	-	-	TrkA_C
TLS2_k127_6743257_2	1313172.YM304_33690	3.338e-131	431.0	COG0475@1|root,COG0475@2|Bacteria,2GJ69@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sodium hydrogen exchanger	kefB	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
TLS2_k127_6743257_7	1463903.JOIZ01000003_gene1628	5.616e-61	222.0	28NTT@1|root,2ZBSA@2|Bacteria,2IB47@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_6743257_1	1124983.PFLCHA0_c30430	4.326e-134	432.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,1RR3Z@1236|Gammaproteobacteria,1YUQU@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_6743257_8	1206101.AZXC01000010_gene47	5.968e-48	179.0	COG1309@1|root,COG1309@2|Bacteria,2ICRJ@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_6743257_12	1122223.KB890688_gene1837	1.042e-37	144.0	COG1694@1|root,COG1694@2|Bacteria,1WK7E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM MazG nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
TLS2_k127_6780156_13	298653.Franean1_2597	9.483e-08	63.0	COG2132@1|root,COG2132@2|Bacteria,2I8HQ@201174|Actinobacteria,4EW3Q@85013|Frankiales	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6780156_7	477641.MODMU_3260	4.757e-51	183.0	COG0640@1|root,COG0640@2|Bacteria,2IKQY@201174|Actinobacteria,4EVH9@85013|Frankiales	201174|Actinobacteria	K	transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_6780156_4	477641.MODMU_3261	8.757e-66	228.0	COG3832@1|root,COG3832@2|Bacteria,2IHTJ@201174|Actinobacteria,4ESXN@85013|Frankiales	201174|Actinobacteria	S	Activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_6780156_6	234621.RER_58640	1.185e-54	209.0	COG0596@1|root,COG0596@2|Bacteria,2I9EM@201174|Actinobacteria	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_6780156_11	1028800.RG540_PA10970	1.019e-16	93.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2UGES@28211|Alphaproteobacteria,4BHHN@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
TLS2_k127_6780156_0	443218.AS9A_0814	1.017e-134	437.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,233G9@1762|Mycobacteriaceae	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_6780156_1	1033730.CAHG01000016_gene463	1.181e-118	391.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,4DQ35@85009|Propionibacteriales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_6780156_10	1380393.JHVP01000019_gene78	6.561e-18	85.0	2EGSG@1|root,33AIJ@2|Bacteria,2GWW3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HHH_5
TLS2_k127_6780156_9	68219.JNXI01000020_gene8075	1.142e-19	97.0	COG0500@1|root,COG2226@2|Bacteria,2GP9N@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_6780156_8	1502724.FF80_02785	3.388e-34	138.0	COG0645@1|root,COG0645@2|Bacteria,1N5P7@1224|Proteobacteria,2UFVE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18
TLS2_k127_6780156_2	1206741.BAFX01000050_gene2291	2.684e-74	262.0	COG4221@1|root,COG4221@2|Bacteria,2I7UD@201174|Actinobacteria,4G6I1@85025|Nocardiaceae	201174|Actinobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_6780156_12	797114.C475_20972	4.29e-08	66.0	COG1520@1|root,arCOG02482@2157|Archaea,2XYGT@28890|Euryarchaeota,23WBY@183963|Halobacteria	183963|Halobacteria	S	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
TLS2_k127_6780156_3	1123024.AUII01000015_gene3750	4.308e-74	258.0	COG0654@1|root,COG0654@2|Bacteria,2GK7I@201174|Actinobacteria,4DXC9@85010|Pseudonocardiales	201174|Actinobacteria	CH	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_binding_3,FAD_oxidored
TLS2_k127_6812747_1	1229780.BN381_130375	3.972e-273	861.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,3UX5E@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	drug exporters of the RND superfamily	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	CarboxypepD_reg,MMPL
TLS2_k127_6812747_7	652103.Rpdx1_1156	1.123e-34	144.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2TU8W@28211|Alphaproteobacteria,3JWK0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_6812747_5	252305.OB2597_06880	8.027e-75	260.0	COG1024@1|root,COG1024@2|Bacteria,1PESW@1224|Proteobacteria,2V7VH@28211|Alphaproteobacteria,2PEMS@252301|Oceanicola	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_6812747_4	1194972.MVAC_02169	7.381e-91	329.0	COG2186@1|root,COG2186@2|Bacteria,2I9KG@201174|Actinobacteria,235J3@1762|Mycobacteriaceae	201174|Actinobacteria	K	FCD domain	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_6812747_3	1172185.KB911525_gene3998	3.935e-92	310.0	COG1024@1|root,COG1024@2|Bacteria,2I2PC@201174|Actinobacteria,4FY8V@85025|Nocardiaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_6812747_0	471852.Tcur_2603	0.0	1020.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4EFXA@85012|Streptosporangiales	201174|Actinobacteria	I	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_6812747_2	909613.UO65_2312	3.87e-92	316.0	COG0438@1|root,COG0438@2|Bacteria,2I005@201174|Actinobacteria,4DXXN@85010|Pseudonocardiales	201174|Actinobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_6812747_6	953739.SVEN_7252	1.095e-57	220.0	COG4671@1|root,COG4671@2|Bacteria,2HKUF@201174|Actinobacteria	201174|Actinobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,Glyco_transf_7C
TLS2_k127_6812747_8	391624.OIHEL45_00842	6.643e-20	104.0	COG1216@1|root,COG1216@2|Bacteria,1Q56M@1224|Proteobacteria,2U27W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_2,Glyco_tranf_2_3,Glyco_transf_7C,Glycos_transf_2
TLS2_k127_6841404_2	889378.Spiaf_2494	2.393e-100	353.0	COG0395@1|root,COG0395@2|Bacteria,2J5Z6@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119,ko:K10234	ko02010,map02010	M00196,M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28,3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
TLS2_k127_6841404_4	118168.MC7420_8037	3.084e-94	321.0	COG1175@1|root,COG1175@2|Bacteria,1G3BG@1117|Cyanobacteria,1H8SB@1150|Oscillatoriales	1117|Cyanobacteria	G	COG1175 ABC-type sugar transport systems permease components	-	-	-	ko:K10233	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
TLS2_k127_6841404_3	889378.Spiaf_2496	3.032e-100	343.0	COG1653@1|root,COG1653@2|Bacteria,2J6W1@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1
TLS2_k127_6841404_0	469383.Cwoe_2935	5.214e-164	525.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4CPPT@84995|Rubrobacteria	84995|Rubrobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
TLS2_k127_6841404_1	485913.Krac_4715	9.516e-134	442.0	COG2272@1|root,COG2272@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
TLS2_k127_6942395_21	1121370.AQUY01000001_gene584	9.299e-19	94.0	COG1104@1|root,COG1104@2|Bacteria,2GKUT@201174|Actinobacteria,22K9Y@1653|Corynebacteriaceae	201174|Actinobacteria	E	Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes	iscS	GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS2_k127_6942395_15	1121877.JQKF01000016_gene162	1.771e-43	167.0	COG2345@1|root,COG2345@2|Bacteria,2HGTI@201174|Actinobacteria,4CNV8@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_6942395_1	1229780.BN381_310061	2.714e-190	599.0	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,3UWC1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0008150,GO:0040007	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
TLS2_k127_6942395_6	1229780.BN381_310065	2.793e-113	374.0	COG0003@1|root,COG0003@2|Bacteria,2GJ0J@201174|Actinobacteria	201174|Actinobacteria	D	Pfam Anion-transporting ATPase	arsA_2	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
TLS2_k127_6942395_2	1229780.BN381_310066	6.286e-141	470.0	COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria	201174|Actinobacteria	D	anion-transporting ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
TLS2_k127_6942395_3	1313172.YM304_09850	1.051e-132	441.0	COG3920@1|root,COG3920@2|Bacteria,2GKMP@201174|Actinobacteria,4CMRV@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Histidine kinase	-	-	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,H_kinase_N,HisKA_2
TLS2_k127_6942395_17	1229780.BN381_310068	1.706e-37	143.0	2DMIE@1|root,32RSG@2|Bacteria,2IQCG@201174|Actinobacteria,3UWR8@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB	GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS2_k127_6942395_16	709986.Deima_0076	8.204e-39	154.0	COG0584@1|root,COG0584@2|Bacteria,1WK5D@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS2_k127_6942395_8	1313172.YM304_09900	5.635e-96	325.0	COG1597@1|root,COG1597@2|Bacteria,2HH1A@201174|Actinobacteria,4CP1H@84992|Acidimicrobiia	2|Bacteria	G	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS2_k127_6942395_5	1229780.BN381_310071	2.076e-121	393.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,3UWNK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
TLS2_k127_6942395_4	1229780.BN381_310072	8.753e-125	407.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,3UWMR@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Electron transfer flavoprotein FAD-binding domain	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TLS2_k127_6942395_20	675635.Psed_4350	2.595e-19	100.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	amgP	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_6942395_22	326427.Cagg_1872	1.051e-18	95.0	COG1146@1|root,COG1146@2|Bacteria,2G75G@200795|Chloroflexi,375SD@32061|Chloroflexia	32061|Chloroflexia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4
TLS2_k127_6942395_14	1237500.ANBA01000007_gene3003	1.019e-60	212.0	COG4405@1|root,COG4405@2|Bacteria,2IFEU@201174|Actinobacteria	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS2_k127_6942395_12	1150398.JIBJ01000008_gene614	1.015e-77	267.0	COG5032@1|root,COG5032@2|Bacteria,2GME7@201174|Actinobacteria,1W9WA@1268|Micrococcaceae	201174|Actinobacteria	BDLTU	Phosphatidylinositol	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6942395_18	644283.Micau_2916	8.646e-33	134.0	298YA@1|root,2ZW25@2|Bacteria,2GIYI@201174|Actinobacteria,4D9TX@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
TLS2_k127_6942395_13	1313172.YM304_10000	1.405e-74	256.0	COG0406@1|root,COG0406@2|Bacteria,2GK8N@201174|Actinobacteria,4CNCR@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Histidine phosphatase superfamily (branch 1)	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
TLS2_k127_6942395_9	1313172.YM304_10010	3.083e-90	304.0	COG1573@1|root,COG1573@2|Bacteria,2GK1I@201174|Actinobacteria,4CNUH@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_6942395_0	1229780.BN381_310078	9.91e-194	610.0	COG1035@1|root,COG1146@1|root,COG1035@2|Bacteria,COG1146@2|Bacteria,2GRHK@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4_9,FrhB_FdhB_C,FrhB_FdhB_N
TLS2_k127_6942395_10	1229780.BN381_310079	4.253e-87	308.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria,3UXS8@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	yvhJ	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
TLS2_k127_6942395_11	35754.JNYJ01000035_gene3928	1.058e-80	278.0	COG4221@1|root,COG4221@2|Bacteria,2I2DY@201174|Actinobacteria,4D8XM@85008|Micromonosporales	201174|Actinobacteria	S	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_6942395_19	309801.trd_A0415	7.858e-25	120.0	COG1595@1|root,COG1595@2|Bacteria,2GBDV@200795|Chloroflexi,27Z17@189775|Thermomicrobia	189775|Thermomicrobia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
TLS2_k127_6942395_7	1283299.AUKG01000001_gene2207	1.851e-107	358.0	COG2895@1|root,COG2895@2|Bacteria,2GJDX@201174|Actinobacteria,4CPIF@84995|Rubrobacteria	84995|Rubrobacteria	P	Elongation factor Tu GTP binding domain	-	-	2.7.7.4	ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_EFTU
TLS2_k127_6944494_1	1313172.YM304_07800	6.879e-86	298.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,4CNC4@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Pfam:Zinicin_2	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
TLS2_k127_6944494_3	1313172.YM304_09000	1.132e-60	226.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria	201174|Actinobacteria	GM	Epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS2_k127_6944494_6	1449351.RISW2_07020	4.729e-35	150.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,4KM4V@93682|Roseivivax	28211|Alphaproteobacteria	O	PDZ domain (Also known as DHR or GLGF)	degPch1	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_6944494_5	1313172.YM304_09020	1.766e-45	169.0	COG0314@1|root,COG0314@2|Bacteria,2HG21@201174|Actinobacteria,4CN80@84992|Acidimicrobiia	84992|Acidimicrobiia	H	MoaE protein	-	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
TLS2_k127_6944494_0	1313172.YM304_09040	3.783e-146	469.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4CMUQ@84992|Acidimicrobiia	201174|Actinobacteria	D	Cell division protein FtsA	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TLS2_k127_6944494_2	1120949.KB903339_gene7989	5.363e-68	236.0	COG0346@1|root,COG0454@1|root,COG0346@2|Bacteria,COG0456@2|Bacteria,2GMTB@201174|Actinobacteria,4DBF4@85008|Micromonosporales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_6944494_4	1313172.YM304_05060	7.331e-51	188.0	COG1413@1|root,COG1413@2|Bacteria,2HA0J@201174|Actinobacteria,4CNCY@84992|Acidimicrobiia	84992|Acidimicrobiia	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
TLS2_k127_700313_10	479435.Kfla_5221	1.342e-20	97.0	COG0017@1|root,COG0017@2|Bacteria,2I2KQ@201174|Actinobacteria,4DQ32@85009|Propionibacteriales	201174|Actinobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12,6.1.1.23	ko:K01876,ko:K09759	ko00970,map00970	M00359,M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_2,tRNA_anti-codon
TLS2_k127_700313_2	2002.JOEQ01000004_gene2872	1.969e-72	259.0	COG2162@1|root,COG2162@2|Bacteria,2GP1R@201174|Actinobacteria,4EHT5@85012|Streptosporangiales	201174|Actinobacteria	Q	N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_2
TLS2_k127_700313_11	1197130.BAFM01000005_gene1125	1.214e-08	63.0	COG1051@1|root,arCOG01075@2157|Archaea,2Y6WI@28890|Euryarchaeota,23YYM@183963|Halobacteria	1197130.BAFM01000005_gene1125|-	L	Hydrolase of X-linked nucleoside diphosphate N terminal	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_700313_3	1121946.AUAX01000014_gene1221	2.576e-68	246.0	COG0697@1|root,COG0697@2|Bacteria,2GMPB@201174|Actinobacteria,4DC89@85008|Micromonosporales	201174|Actinobacteria	EG	EamA-like transporter family	pecM	-	-	ko:K15269	-	-	-	-	ko00000,ko02000	2.A.7.3.3	-	-	EamA
TLS2_k127_700313_5	390989.JOEG01000014_gene2997	5.477e-45	168.0	COG1846@1|root,COG1846@2|Bacteria,2GJ6W@201174|Actinobacteria,4DEDI@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS2_k127_700313_8	1246995.AFR_04200	1.678e-37	152.0	COG2045@1|root,COG2045@2|Bacteria,2HVVW@201174|Actinobacteria,4DHYI@85008|Micromonosporales	201174|Actinobacteria	H	2-phosphosulpholactate phosphatase	-	-	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
TLS2_k127_700313_4	471853.Bcav_1104	4.084e-59	220.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	-	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
TLS2_k127_700313_0	391625.PPSIR1_25106	4.395e-98	336.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	ko:K03817	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS2_k127_700313_6	405948.SACE_0740	5.455e-43	163.0	COG3981@1|root,COG3981@2|Bacteria,2IGK9@201174|Actinobacteria,4E4TP@85010|Pseudonocardiales	201174|Actinobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
TLS2_k127_700313_9	235985.BBPN01000017_gene5677	8.431e-21	97.0	COG0789@1|root,COG0789@2|Bacteria,2IC98@201174|Actinobacteria,2NGH2@228398|Streptacidiphilus	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_700313_7	981369.JQMJ01000004_gene4147	2.582e-39	158.0	COG0500@1|root,COG2226@2|Bacteria,2HERR@201174|Actinobacteria,2NKQT@228398|Streptacidiphilus	201174|Actinobacteria	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_700313_1	479435.Kfla_2519	2.598e-93	314.0	COG1335@1|root,COG1335@2|Bacteria,2GM4F@201174|Actinobacteria	201174|Actinobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS2_k127_700313_12	981383.AEWH01000059_gene2213	0.0001658	50.0	COG3714@1|root,COG3714@2|Bacteria	2|Bacteria	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
TLS2_k127_7015507_7	1313172.YM304_10790	6.12e-68	236.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,4CMYM@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_7015507_8	1122939.ATUD01000002_gene1205	1.155e-67	240.0	COG0705@1|root,COG0705@2|Bacteria,2GJYG@201174|Actinobacteria,4CQ6Z@84995|Rubrobacteria	84995|Rubrobacteria	S	Rhomboid family	-	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid
TLS2_k127_7015507_3	525909.Afer_0499	1.301e-105	368.0	COG1085@1|root,COG1085@2|Bacteria,2I2DM@201174|Actinobacteria,4CMV6@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Domain of unknown function (DUF4921)	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_transf
TLS2_k127_7015507_10	1313172.YM304_12290	6.067e-57	208.0	COG0500@1|root,COG0500@2|Bacteria,2I3YC@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_7015507_5	306281.AJLK01000020_gene2971	4.344e-81	287.0	COG0605@1|root,COG0605@2|Bacteria,1G0N2@1117|Cyanobacteria,1JJGW@1189|Stigonemataceae	1117|Cyanobacteria	P	Iron/manganese superoxide dismutases, alpha-hairpin domain	sodB	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
TLS2_k127_7015507_2	1313172.YM304_12550	4.71e-117	388.0	COG1104@1|root,COG1104@2|Bacteria,2GKUT@201174|Actinobacteria,4CN5Q@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aminotransferase class-V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS2_k127_7015507_1	1313172.YM304_12560	1.681e-124	413.0	COG0482@1|root,COG0482@2|Bacteria,2GIUQ@201174|Actinobacteria,4CMY8@84992|Acidimicrobiia	84992|Acidimicrobiia	J	tRNA methyl transferase	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TLS2_k127_7015507_13	1313172.YM304_12570	6.692e-38	158.0	2CDEB@1|root,2ZRID@2|Bacteria,2HDK8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7015507_9	1313172.YM304_12580	1.364e-62	228.0	COG0620@1|root,COG0620@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
TLS2_k127_7015507_0	1229780.BN381_10084	8.244e-243	776.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,3UW7F@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
TLS2_k127_7015507_6	446466.Cfla_2064	2.637e-80	291.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4F0JI@85016|Cellulomonadaceae	201174|Actinobacteria	KLT	PFAM Serine threonine-protein kinase-like domain	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_7015507_17	1713.JOFV01000028_gene715	2.757e-16	87.0	COG0745@1|root,COG0745@2|Bacteria,2IQE3@201174|Actinobacteria,4F2SD@85016|Cellulomonadaceae	201174|Actinobacteria	KT	RESPONSE REGULATOR receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7015507_14	1184607.AUCHE_26_00190	2.804e-37	144.0	COG0745@1|root,COG0745@2|Bacteria,2IM7B@201174|Actinobacteria,4F70J@85018|Dermatophilaceae	201174|Actinobacteria	KT	cheY-homologous receiver domain	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
TLS2_k127_7015507_11	397278.JOJN01000001_gene2881	2.451e-49	193.0	COG1344@1|root,COG1344@2|Bacteria,2IA40@201174|Actinobacteria,4DNBS@85009|Propionibacteriales	201174|Actinobacteria	N	Bacterial flagellin C-terminal helical region	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
TLS2_k127_7015507_4	1048339.KB913029_gene899	5.145e-98	338.0	COG1256@1|root,COG1256@2|Bacteria,2GNXQ@201174|Actinobacteria,4ES71@85013|Frankiales	201174|Actinobacteria	N	flagellar hook-associated protein	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TLS2_k127_7015507_16	935866.JAER01000071_gene1361	7.653e-25	116.0	2B12R@1|root,31TG8@2|Bacteria,2IQ5J@201174|Actinobacteria,4DRX1@85009|Propionibacteriales	201174|Actinobacteria	S	FlgN protein	flgN	-	-	-	-	-	-	-	-	-	-	-	FlgN
TLS2_k127_7015507_15	1095772.CAHH01000049_gene61	1.293e-32	128.0	COG1344@1|root,COG1344@2|Bacteria,2GUKT@201174|Actinobacteria	201174|Actinobacteria	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	hag	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
TLS2_k127_70456_2	357808.RoseRS_1298	2.486e-67	237.0	COG2343@1|root,COG2343@2|Bacteria,2GARM@200795|Chloroflexi,3775Q@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
TLS2_k127_70456_0	909613.UO65_3523	2.975e-181	571.0	COG1741@1|root,COG1741@2|Bacteria,2GIY9@201174|Actinobacteria,4DXA1@85010|Pseudonocardiales	201174|Actinobacteria	S	Pirin C-terminal cupin domain	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
TLS2_k127_70456_3	882083.SacmaDRAFT_0136	1.205e-28	122.0	2DPEX@1|root,331T0@2|Bacteria,2IR24@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS2_k127_70456_1	1157637.KB892090_gene6581	4.213e-74	265.0	COG0500@1|root,COG0500@2|Bacteria,2IGTT@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7115501_2	640512.BC1003_4747	1.804e-114	391.0	COG1488@1|root,COG1488@2|Bacteria,1QD76@1224|Proteobacteria,2WE4J@28216|Betaproteobacteria,1K19E@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
TLS2_k127_7115501_7	656024.FsymDg_2568	3.468e-57	209.0	COG1335@1|root,COG1335@2|Bacteria,2IFQW@201174|Actinobacteria,4ET2V@85013|Frankiales	201174|Actinobacteria	Q	PFAM isochorismatase hydrolase	pncA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
TLS2_k127_7115501_6	479434.Sthe_0102	1.035e-69	253.0	COG0420@1|root,COG0420@2|Bacteria	2|Bacteria	L	3'-5' exonuclease activity	yhaO	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
TLS2_k127_7115501_1	479434.Sthe_0103	3.736e-139	481.0	COG0419@1|root,COG4717@1|root,COG0419@2|Bacteria,COG4717@2|Bacteria	2|Bacteria	S	serine-type aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_27
TLS2_k127_7115501_11	1380347.JNII01000007_gene526	4.373e-38	158.0	COG3860@1|root,COG3860@2|Bacteria,2IQEK@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2087)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087,HTH_20
TLS2_k127_7115501_3	1229780.BN381_80314	1.264e-106	361.0	COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria,3UXSW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_7115501_10	134676.ACPL_5040	1.411e-40	159.0	COG1674@1|root,COG2230@1|root,COG1674@2|Bacteria,COG2230@2|Bacteria,2GJBR@201174|Actinobacteria,4D8WW@85008|Micromonosporales	201174|Actinobacteria	D	DNA segregation ATPase FtsK SpoIIIE and related proteins	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE
TLS2_k127_7115501_5	1121127.JAFA01000093_gene2975	5.611e-71	262.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K0RA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
TLS2_k127_7115501_4	1229780.BN381_90083	1.745e-86	294.0	COG1192@1|root,COG1192@2|Bacteria,2H4UC@201174|Actinobacteria	201174|Actinobacteria	D	chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS2_k127_7115501_0	1229780.BN381_50061	9.146e-162	524.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,3UWHX@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
TLS2_k127_7115501_12	711393.AYRX01000033_gene58	6.69e-20	95.0	COG0517@1|root,COG0517@2|Bacteria,2IHPB@201174|Actinobacteria	201174|Actinobacteria	S	Cbs domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_7115501_8	367299.JOEE01000004_gene1085	3.1e-43	171.0	COG2335@1|root,COG2335@2|Bacteria	2|Bacteria	M	COG2335, Secreted and surface protein containing fasciclin-like repeats	-	-	-	ko:K19519	-	-	-	-	ko00000,ko04516	-	-	-	Fasciclin,Lipoprotein_15
TLS2_k127_717782_19	1313172.YM304_28510	1.794e-19	101.0	COG1266@1|root,COG1266@2|Bacteria,2H0BD@201174|Actinobacteria,4CNBE@84992|Acidimicrobiia	84992|Acidimicrobiia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_717782_2	1229780.BN381_10199	1.835e-175	579.0	COG5617@1|root,COG5617@2|Bacteria,2H32H@201174|Actinobacteria	201174|Actinobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_717782_10	1229780.BN381_130002	1.462e-70	250.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_717782_3	1229780.BN381_10200	1.124e-170	552.0	COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,3UWAW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	manB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_717782_17	1229780.BN381_10201	1.735e-22	110.0	COG2835@1|root,COG2835@2|Bacteria	2|Bacteria	EG	tetraacyldisaccharide 4'-kinase activity	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
TLS2_k127_717782_9	1229780.BN381_10202	1.076e-71	255.0	COG2222@1|root,COG2222@2|Bacteria,2HGM1@201174|Actinobacteria,3UXD9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Bacterial phospho-glucose isomerase C-terminal SIS domain	-	-	-	-	-	-	-	-	-	-	-	-	SIS,bact-PGI_C
TLS2_k127_717782_1	479435.Kfla_1604	2.749e-255	795.0	COG0499@1|root,COG0499@2|Bacteria,2GK2Q@201174|Actinobacteria,4DPQG@85009|Propionibacteriales	201174|Actinobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0000098,GO:0000166,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009087,GO:0009116,GO:0009119,GO:0009987,GO:0016020,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0019899,GO:0022610,GO:0030260,GO:0030312,GO:0033353,GO:0034641,GO:0035375,GO:0035635,GO:0036094,GO:0040007,GO:0042278,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044650,GO:0046085,GO:0046128,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055086,GO:0070403,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS2_k127_717782_13	1123279.ATUS01000001_gene2758	1.46e-57	212.0	COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,1S354@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	ptlF	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_717782_12	1236902.ANAS01000031_gene2833	2.336e-59	222.0	COG2364@1|root,COG2364@2|Bacteria,2GKA1@201174|Actinobacteria,4EJ10@85012|Streptosporangiales	201174|Actinobacteria	S	membrane	-	-	-	ko:K07149	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_717782_18	1313172.YM304_28380	8.345e-22	110.0	COG1040@1|root,COG1040@2|Bacteria	2|Bacteria	K	competence protein	comF	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pribosyltran
TLS2_k127_717782_16	1394178.AWOO02000035_gene8997	1.566e-30	128.0	COG2197@1|root,COG2197@2|Bacteria,2IFE7@201174|Actinobacteria,4EMXI@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_717782_0	1229780.BN381_80106	0.0	1265.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,3UW8Q@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TLS2_k127_717782_4	1229780.BN381_80107	1.534e-126	414.0	COG1186@1|root,COG1186@2|Bacteria,2GJ0F@201174|Actinobacteria,3UW7K@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS2_k127_717782_7	1229780.BN381_80108	6.337e-115	373.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,3UW73@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	ATPases associated with a variety of cellular activities	ftsE	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
TLS2_k127_717782_11	525909.Afer_1760	3.117e-65	233.0	COG2177@1|root,COG2177@2|Bacteria,2GJMA@201174|Actinobacteria,4CN4Q@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
TLS2_k127_717782_21	105420.BBPO01000085_gene4949	5.697e-09	61.0	2E45J@1|root,32Z1K@2|Bacteria,2GR89@201174|Actinobacteria,2NJBU@228398|Streptacidiphilus	201174|Actinobacteria	S	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
TLS2_k127_717782_14	1303692.SFUL_5682	4.867e-53	197.0	COG1296@1|root,COG1296@2|Bacteria,2GN6R@201174|Actinobacteria	201174|Actinobacteria	E	branched-chain amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
TLS2_k127_717782_5	1313172.YM304_32220	1.016e-122	427.0	COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4CNHH@84992|Acidimicrobiia	201174|Actinobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP
TLS2_k127_717782_6	1323663.AROI01000020_gene690	1.047e-121	396.0	COG1024@1|root,COG1024@2|Bacteria,1MVPQ@1224|Proteobacteria,1SYQM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	COG1024 Enoyl-CoA hydratase carnithine racemase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_717782_8	443218.AS9A_2601	2.72e-76	261.0	COG1225@1|root,COG1225@2|Bacteria,2II4M@201174|Actinobacteria,234YH@1762|Mycobacteriaceae	201174|Actinobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_717782_15	1232437.KL662036_gene2717	4.776e-33	130.0	COG1028@1|root,COG3427@1|root,COG1028@2|Bacteria,COG3427@2|Bacteria,1P9R4@1224|Proteobacteria,42TE9@68525|delta/epsilon subdivisions,2WPGF@28221|Deltaproteobacteria,2MIUD@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2,adh_short
TLS2_k127_7202801_1	1120950.KB892775_gene1166	3.548e-234	737.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4DNNQ@85009|Propionibacteriales	201174|Actinobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL2	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS2_k127_7202801_21	525909.Afer_0443	2.79e-44	162.0	COG0234@1|root,COG0234@2|Bacteria,2IKTH@201174|Actinobacteria,4CN66@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TLS2_k127_7202801_3	1313172.YM304_08960	3.899e-141	457.0	COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria,4CMUH@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TLS2_k127_7202801_22	1229780.BN381_130035	1.483e-39	155.0	COG0454@1|root,COG0456@2|Bacteria,2IM9R@201174|Actinobacteria,3UWXZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	FR47-like protein	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TLS2_k127_7202801_9	1313172.YM304_08940	1.843e-81	279.0	COG1214@1|root,COG1214@2|Bacteria	2|Bacteria	O	tRNA threonylcarbamoyladenosine modification	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TLS2_k127_7202801_25	1313172.YM304_08930	1.871e-31	131.0	COG0802@1|root,COG0802@2|Bacteria,2IKV2@201174|Actinobacteria,4CNEU@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
TLS2_k127_7202801_11	1151061.CAJY01000010_gene172	7.81e-78	273.0	COG3191@1|root,COG3191@2|Bacteria,2GJKQ@201174|Actinobacteria	201174|Actinobacteria	EQ	peptidase S58, DmpA	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
TLS2_k127_7202801_30	1380390.JIAT01000011_gene2523	1.322e-14	82.0	COG1309@1|root,COG1309@2|Bacteria,2I48E@201174|Actinobacteria,4CRPN@84995|Rubrobacteria	84995|Rubrobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_7202801_24	1206726.BAFV01000025_gene1832	2.665e-36	145.0	COG0454@1|root,COG0456@2|Bacteria,2I9Y3@201174|Actinobacteria,4G0P0@85025|Nocardiaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_7202801_8	1313172.YM304_08920	2.876e-97	331.0	COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4CN11@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TLS2_k127_7202801_27	469383.Cwoe_1887	1.342e-27	118.0	COG0517@1|root,COG0517@2|Bacteria,2HPZ3@201174|Actinobacteria,4CREF@84995|Rubrobacteria	84995|Rubrobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_7202801_6	1313172.YM304_08910	9.543e-109	372.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2GJHB@201174|Actinobacteria,4CMZ5@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
TLS2_k127_7202801_29	562970.Btus_1798	2.56e-21	103.0	COG2138@1|root,COG2138@2|Bacteria,1TRDV@1239|Firmicutes,4HQSK@91061|Bacilli,278MT@186823|Alicyclobacillaceae	91061|Bacilli	S	CbiX	-	-	-	-	-	-	-	-	-	-	-	-	CbiX
TLS2_k127_7202801_26	1313172.YM304_08850	1.28e-28	120.0	COG0736@1|root,COG0736@2|Bacteria,2HGFC@201174|Actinobacteria,4CND0@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_7202801_0	1229780.BN381_130026	0.0	1237.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,3UWEV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iNJ661.Rv3436c	GATase_6,SIS
TLS2_k127_7202801_5	1048339.KB913029_gene2783	1.35e-121	406.0	COG1109@1|root,COG1109@2|Bacteria,2GN87@201174|Actinobacteria,4ERSE@85013|Frankiales	201174|Actinobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	GO:0008150,GO:0040007	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_7202801_18	1229780.BN381_130024	6.614e-53	190.0	COG0103@1|root,COG0103@2|Bacteria,2GNDY@201174|Actinobacteria,3UWN9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
TLS2_k127_7202801_17	882082.SaccyDRAFT_0536	1.87e-57	211.0	COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4E2WQ@85010|Pseudonocardiales	201174|Actinobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
TLS2_k127_7202801_32	1218076.BAYB01000026_gene4421	2.156e-05	51.0	2C4HP@1|root,317DY@2|Bacteria,1PYQ4@1224|Proteobacteria,2WDV3@28216|Betaproteobacteria,1KB1V@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7202801_14	1313172.YM304_08770	1.201e-63	231.0	COG0101@1|root,COG0101@2|Bacteria,2GJ6C@201174|Actinobacteria,4CNBD@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
TLS2_k127_7202801_20	1229780.BN381_450070	5.605e-45	167.0	COG0203@1|root,COG0203@2|Bacteria,2IHV2@201174|Actinobacteria,3UWTF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
TLS2_k127_7202801_4	1229780.BN381_450071	2.364e-138	446.0	COG0202@1|root,COG0202@2|Bacteria,2GJJ5@201174|Actinobacteria,3UW7R@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
TLS2_k127_7202801_7	1229780.BN381_450072	5.979e-102	334.0	COG0522@1|root,COG0522@2|Bacteria,2GIRX@201174|Actinobacteria,3UWKS@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
TLS2_k127_7202801_13	1229780.BN381_450073	7.634e-67	229.0	COG0100@1|root,COG0100@2|Bacteria,2IFFC@201174|Actinobacteria,3UWJ3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
TLS2_k127_7202801_16	1229780.BN381_450074	1.166e-57	202.0	COG0099@1|root,COG0099@2|Bacteria,2IHPN@201174|Actinobacteria,3UWMD@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
TLS2_k127_7202801_31	866774.HMPREF9248_0553	2.301e-13	72.0	COG0257@1|root,COG0257@2|Bacteria,2GWMH@201174|Actinobacteria,4CWQV@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
TLS2_k127_7202801_23	525909.Afer_0421	1.618e-36	140.0	COG0361@1|root,COG0361@2|Bacteria,2IQ4B@201174|Actinobacteria,4CNX6@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
TLS2_k127_7202801_10	756499.Desde_0446	8.741e-80	278.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,260SK@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS2_k127_7202801_19	1158318.ATXC01000001_gene1253	4.761e-51	189.0	COG0563@1|root,COG0563@2|Bacteria,2G42Z@200783|Aquificae	200783|Aquificae	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK
TLS2_k127_7202801_2	1229780.BN381_450077	3.614e-171	547.0	COG0201@1|root,COG0201@2|Bacteria,2GJ26@201174|Actinobacteria,3UWEW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
TLS2_k127_7202801_15	1229780.BN381_450078	9.276e-62	221.0	COG0200@1|root,COG0200@2|Bacteria,2II6M@201174|Actinobacteria,3UWM5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
TLS2_k127_7202801_28	1313172.YM304_08430	1.402e-23	100.0	COG1841@1|root,COG1841@2|Bacteria,2HGDQ@201174|Actinobacteria,4CNC3@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein L30p/L7e	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
TLS2_k127_7202801_12	1229780.BN381_450080	5.386e-73	248.0	COG0098@1|root,COG0098@2|Bacteria,2GJW8@201174|Actinobacteria,3UWH1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
TLS2_k127_7243430_2	1961.JOAK01000002_gene1051	0.0006445	51.0	COG1316@1|root,COG1316@2|Bacteria,2GNGN@201174|Actinobacteria	201174|Actinobacteria	K	LytR cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
TLS2_k127_7243430_1	1313172.YM304_26740	6.261e-32	131.0	COG0799@1|root,COG0799@2|Bacteria,2IKZ3@201174|Actinobacteria,4CN96@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
TLS2_k127_7243430_0	525909.Afer_1322	0.0	1060.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4CMQM@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
TLS2_k127_7343162_5	525909.Afer_1963	4.702e-31	139.0	COG0789@1|root,COG0789@2|Bacteria,2GR1T@201174|Actinobacteria,4CN4Z@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix, mercury resistance	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
TLS2_k127_7343162_1	525909.Afer_1962	5.011e-124	411.0	COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,4CMRG@84992|Acidimicrobiia	84992|Acidimicrobiia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_7343162_6	1229780.BN381_150055	3.224e-27	119.0	COG0576@1|root,COG0576@2|Bacteria,2GP4F@201174|Actinobacteria,3UWXC@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS2_k127_7343162_0	1229780.BN381_150056	1.941e-304	950.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,3UW7G@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	Heat shock 70 kDa protein	dnaK	GO:0000302,GO:0000303,GO:0000305,GO:0001968,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016310,GO:0019222,GO:0019538,GO:0019899,GO:0030112,GO:0030162,GO:0030312,GO:0030313,GO:0031323,GO:0031325,GO:0031975,GO:0031982,GO:0032268,GO:0032270,GO:0033554,GO:0034599,GO:0034614,GO:0035375,GO:0036211,GO:0040007,GO:0042221,GO:0042603,GO:0043170,GO:0043226,GO:0043227,GO:0043230,GO:0043388,GO:0043412,GO:0044044,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046677,GO:0046688,GO:0046777,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051098,GO:0051099,GO:0051101,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070613,GO:0070887,GO:0071450,GO:0071451,GO:0071704,GO:0071944,GO:0080090,GO:0097691,GO:1901564,GO:1901700,GO:1901701,GO:1903317,GO:1903319,GO:1903561,GO:2000677,GO:2000679	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TLS2_k127_7343162_3	479433.Caci_8222	4.712e-100	332.0	COG0588@1|root,COG0588@2|Bacteria,2GK8F@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
TLS2_k127_7343162_4	1120950.KB892757_gene6601	7.734e-34	137.0	COG0539@1|root,COG1595@1|root,COG0539@2|Bacteria,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1,Sigma70_r2,Sigma70_r4_2
TLS2_k127_7343162_2	1183438.GKIL_0853	7.59e-108	369.0	COG0475@1|root,COG0589@1|root,COG0475@2|Bacteria,COG0589@2|Bacteria,1G45B@1117|Cyanobacteria	1117|Cyanobacteria	PT	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,Usp
TLS2_k127_7343323_1	1313172.YM304_29160	3.406e-115	372.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4CP57@84992|Acidimicrobiia	201174|Actinobacteria	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	3.6.3.21	ko:K02028,ko:K09972,ko:K10041	ko02010,map02010	M00228,M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
TLS2_k127_7343323_5	1229780.BN381_90069	3.972e-39	160.0	COG1876@1|root,COG1876@2|Bacteria,2IQI8@201174|Actinobacteria	201174|Actinobacteria	M	peptidase M15B and M15C DD-carboxypeptidase VanY endolysin	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	B_lectin,VanY
TLS2_k127_7343323_6	471856.Jden_0010	1.027e-13	81.0	2CFZ7@1|root,33VW4@2|Bacteria,2H5A3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7343323_2	1206733.BAGC01000019_gene4575	1.538e-98	334.0	COG0500@1|root,COG0500@2|Bacteria,2I2WB@201174|Actinobacteria,4FVBZ@85025|Nocardiaceae	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_25
TLS2_k127_7343323_0	1121272.KB903250_gene2857	2.158e-277	880.0	COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria,4DA3C@85008|Micromonosporales	201174|Actinobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
TLS2_k127_7343323_3	134676.ACPL_1305	9.356e-92	327.0	COG2038@1|root,COG2038@2|Bacteria,2GJ16@201174|Actinobacteria,4D9TI@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU,DBI_PRT,Nitroreductase
TLS2_k127_7343323_4	1043205.AFYF01000021_gene902	9.938e-51	185.0	COG0079@1|root,COG0079@2|Bacteria,2I2ND@201174|Actinobacteria,4FG89@85021|Intrasporangiaceae	201174|Actinobacteria	E	Aminotransferase class I and II	cobC	GO:0008150,GO:0040007	2.6.1.9,4.1.1.81	ko:K00817,ko:K04720	ko00340,ko00350,ko00360,ko00400,ko00401,ko00860,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243,R06530	RC00006,RC00517,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2,CbiG_C
TLS2_k127_7345539_27	1255043.TVNIR_1633	0.0001414	46.0	COG0666@1|root,COG0666@2|Bacteria,1RFV0@1224|Proteobacteria,1S50I@1236|Gammaproteobacteria,1WYBK@135613|Chromatiales	135613|Chromatiales	S	PFAM Ankyrin	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_4,Ank_5
TLS2_k127_7345539_20	394221.Mmar10_2875	1.508e-26	113.0	COG0346@1|root,COG0346@2|Bacteria,1P3AW@1224|Proteobacteria,2V8YJ@28211|Alphaproteobacteria,44024@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Glyoxalase-like domain	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
TLS2_k127_7345539_13	35754.JNYJ01000032_gene1755	1.455e-67	233.0	COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria,4DE55@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB_2
TLS2_k127_7345539_22	102129.Lepto7375DRAFT_8329	4.075e-17	91.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	GNAT_acetyltran
TLS2_k127_7345539_24	365528.KB891219_gene1082	7.232e-14	85.0	COG1403@1|root,COG1403@2|Bacteria,2HAHI@201174|Actinobacteria,4ESDB@85013|Frankiales	201174|Actinobacteria	L	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_7345539_5	1120950.KB892759_gene6228	8.289e-155	507.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4DPPG@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS2_k127_7345539_10	1116232.AHBF01000116_gene4432	4.152e-85	294.0	COG1846@1|root,COG1846@2|Bacteria,2GMDI@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7345539_0	483219.LILAB_26095	1.164e-300	951.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2YUAS@29|Myxococcales	28221|Deltaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS2_k127_7345539_26	58123.JOFJ01000005_gene1294	6.864e-05	54.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,2GKN1@201174|Actinobacteria,4EM26@85012|Streptosporangiales	201174|Actinobacteria	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
TLS2_k127_7345539_1	1151119.KB895489_gene650	8.88e-261	818.0	COG0365@1|root,COG0365@2|Bacteria,2GNE8@201174|Actinobacteria	201174|Actinobacteria	I	synthetase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_7345539_6	1449044.JMLE01000029_gene105	3.263e-136	449.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS2_k127_7345539_4	1449044.JMLE01000029_gene106	1.278e-157	509.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,1WAY5@1268|Micrococcaceae	201174|Actinobacteria	C	Transketolase, C-terminal domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_7345539_7	55952.BU52_03405	1.709e-121	405.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria	201174|Actinobacteria	C	acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_7345539_23	1101188.KI912155_gene2607	3.512e-16	84.0	COG0236@1|root,COG0236@2|Bacteria,2GRZ8@201174|Actinobacteria	201174|Actinobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
TLS2_k127_7345539_8	526225.Gobs_2269	5.185e-114	376.0	COG1234@1|root,COG1234@2|Bacteria,2GJT2@201174|Actinobacteria	201174|Actinobacteria	S	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
TLS2_k127_7345539_15	425104.Ssed_3642	1.606e-59	212.0	COG3911@1|root,COG3911@2|Bacteria,1RBSG@1224|Proteobacteria,1S31D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_28
TLS2_k127_7345539_3	981369.JQMJ01000004_gene581	6.459e-161	527.0	COG1236@1|root,COG1236@2|Bacteria,2HEXB@201174|Actinobacteria,2NK0D@228398|Streptacidiphilus	201174|Actinobacteria	J	Zn-dependent metallo-hydrolase RNA specificity domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL
TLS2_k127_7345539_25	1120950.KB892739_gene3971	1.494e-07	57.0	COG0316@1|root,COG0316@2|Bacteria,2GR0Z@201174|Actinobacteria,4DS4Z@85009|Propionibacteriales	201174|Actinobacteria	S	HesB YadR YfhF-family protein	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_biosyn
TLS2_k127_7345539_19	1089551.KE386572_gene4706	1.468e-30	137.0	COG2199@1|root,COG5001@1|root,COG3706@2|Bacteria,COG5001@2|Bacteria,1QUXS@1224|Proteobacteria,2TYAE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3,PAS_9
TLS2_k127_7345539_18	1386089.N865_01770	6.56e-34	138.0	COG4244@1|root,COG5592@1|root,COG4244@2|Bacteria,COG5592@2|Bacteria,2I2FH@201174|Actinobacteria,4FGW1@85021|Intrasporangiaceae	201174|Actinobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
TLS2_k127_7345539_16	1121017.AUFG01000033_gene300	8.138e-54	199.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	acoC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Biotin_lipoyl,E3_binding
TLS2_k127_7345539_9	525909.Afer_0598	1.292e-92	340.0	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,4CN8B@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Mur ligase family, glutamate ligase domain	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
TLS2_k127_7345539_12	1121017.AUFG01000033_gene302	6.143e-74	266.0	COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria,4FEUY@85021|Intrasporangiaceae	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TLS2_k127_7345539_21	1123392.AQWL01000005_gene3163	6.234e-19	92.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,2VWDY@28216|Betaproteobacteria,1KRVV@119069|Hydrogenophilales	119069|Hydrogenophilales	S	DUF167	-	-	-	-	-	-	-	-	-	-	-	-	DUF167
TLS2_k127_7345539_2	1313172.YM304_36330	8.834e-251	798.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 3	bglK	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
TLS2_k127_7345539_17	211114.JOEF01000016_gene3803	2.012e-46	180.0	COG3173@1|root,COG3173@2|Bacteria,2I5FU@201174|Actinobacteria	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_7345539_11	1137269.AZWL01000006_gene6702	1.52e-77	276.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_7345539_14	1157637.KB892101_gene2460	6.258e-62	226.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_7368351_2	1380370.JIBA01000014_gene1723	4.913e-66	236.0	COG3154@1|root,COG3154@2|Bacteria,2I75S@201174|Actinobacteria,4FG6A@85021|Intrasporangiaceae	201174|Actinobacteria	I	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS2_k127_7368351_3	1121033.AUCF01000026_gene2984	1.13e-53	196.0	COG2084@1|root,COG3384@1|root,COG2084@2|Bacteria,COG3384@2|Bacteria,1MX8V@1224|Proteobacteria,2TVBS@28211|Alphaproteobacteria,2JTAE@204441|Rhodospirillales	204441|Rhodospirillales	I	Domain of unknown function (DUF1932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,NAD_binding_2
TLS2_k127_7368351_0	1121033.AUCF01000026_gene2985	1.652e-127	413.0	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2TRP1@28211|Alphaproteobacteria,2JVBN@204441|Rhodospirillales	204441|Rhodospirillales	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	LigA,LigB
TLS2_k127_7368351_1	369723.Strop_1612	6.763e-76	258.0	COG2210@1|root,COG2210@2|Bacteria,2IFXH@201174|Actinobacteria,4DIG7@85008|Micromonosporales	201174|Actinobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
TLS2_k127_7368351_4	369723.Strop_1611	1.09e-38	154.0	COG2920@1|root,COG2920@2|Bacteria,2IQB2@201174|Actinobacteria,4DJKP@85008|Micromonosporales	201174|Actinobacteria	P	DsrC like protein	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
TLS2_k127_7368351_5	926550.CLDAP_11610	7.026e-25	109.0	COG2427@1|root,COG2427@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1641
TLS2_k127_7398458_1	1150864.MILUP08_40910	1.814e-219	728.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4DAF0@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter	yfiC	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_7398458_7	479431.Namu_0808	4.242e-30	130.0	COG1309@1|root,COG1309@2|Bacteria,2IQGF@201174|Actinobacteria,4EVZH@85013|Frankiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_7398458_3	1280949.HAD_00915	3.454e-110	369.0	COG2159@1|root,COG2159@2|Bacteria,1MVTS@1224|Proteobacteria,2VGQX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS2_k127_7398458_5	1120950.KB892813_gene7108	9.437e-75	285.0	2F3NN@1|root,33WFN@2|Bacteria,2IPYP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7398458_6	1449069.JMLO01000032_gene801	8.599e-53	203.0	29RUH@1|root,30CYE@2|Bacteria,2HHM4@201174|Actinobacteria,4FVZD@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7398458_4	1229780.BN381_130299	6.077e-102	339.0	COG1946@1|root,COG1946@2|Bacteria,2H5RX@201174|Actinobacteria	201174|Actinobacteria	I	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
TLS2_k127_7398458_2	479431.Namu_4908	1.207e-172	573.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4EUJP@85013|Frankiales	201174|Actinobacteria	E	Gamma-glutamyltranspeptidase	ywrD	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_7398458_0	713587.THITH_07460	1.194e-228	715.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXRV@135613|Chromatiales	135613|Chromatiales	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS2_k127_7398458_8	1313172.YM304_31960	2.244e-15	79.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,2H3SH@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS2_k127_740597_6	656024.FsymDg_2137	6.391e-147	503.0	COG1572@1|root,COG1572@2|Bacteria,2I56C@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF3367)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3367
TLS2_k127_740597_12	526225.Gobs_2307	5.792e-51	205.0	COG1807@1|root,COG1807@2|Bacteria,2H4N7@201174|Actinobacteria,4EV7X@85013|Frankiales	201174|Actinobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
TLS2_k127_740597_2	1229780.BN381_430045	4.158e-166	552.0	COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria	201174|Actinobacteria	IQ	synthetase	fadD19_2	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_740597_11	1382306.JNIM01000001_gene3962	1.692e-53	193.0	COG0652@1|root,COG0652@2|Bacteria,2G6RE@200795|Chloroflexi	200795|Chloroflexi	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
TLS2_k127_740597_20	1056816.JAFQ01000004_gene7122	7.454e-10	71.0	COG1309@1|root,COG1309@2|Bacteria,2HYI1@201174|Actinobacteria,4G3P9@85025|Nocardiaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TLS2_k127_740597_5	1229780.BN381_50085	1.409e-147	474.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,3UX3T@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_740597_4	1120936.KB907209_gene1792	2.195e-148	482.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,BPD_transp_1,oligo_HPY
TLS2_k127_740597_22	59538.XP_005979922.1	0.0007497	46.0	KOG1868@1|root,KOG1868@2759|Eukaryota,38DC9@33154|Opisthokonta,3BB2H@33208|Metazoa,3CX29@33213|Bilateria,480BI@7711|Chordata,492FI@7742|Vertebrata,3J9NW@40674|Mammalia,4J4UX@91561|Cetartiodactyla	33208|Metazoa	O	ubiquitin specific peptidase 8	USP8	GO:0000278,GO:0000281,GO:0000910,GO:0002009,GO:0002165,GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0004843,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006996,GO:0007032,GO:0007049,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007399,GO:0007444,GO:0007472,GO:0007476,GO:0007552,GO:0007560,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008283,GO:0008587,GO:0008589,GO:0009653,GO:0009719,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0009966,GO:0009967,GO:0009987,GO:0010008,GO:0010033,GO:0010256,GO:0010646,GO:0010647,GO:0012505,GO:0014069,GO:0016020,GO:0016043,GO:0016050,GO:0016322,GO:0016579,GO:0016787,GO:0019538,GO:0019783,GO:0019897,GO:0019898,GO:0021700,GO:0022008,GO:0022402,GO:0023051,GO:0023052,GO:0023056,GO:0030111,GO:0030154,GO:0030177,GO:0030182,GO:0030425,GO:0030496,GO:0031090,GO:0031312,GO:0031313,GO:0031410,GO:0031982,GO:0032279,GO:0032501,GO:0032502,GO:0035107,GO:0035114,GO:0035120,GO:0035220,GO:0035239,GO:0035295,GO:0035556,GO:0036211,GO:0036459,GO:0036477,GO:0042221,GO:0042551,GO:0042995,GO:0043005,GO:0043170,GO:0043197,GO:0043226,GO:0043227,GO:0043229,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044309,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0045202,GO:0045880,GO:0048468,GO:0048469,GO:0048513,GO:0048518,GO:0048522,GO:0048563,GO:0048569,GO:0048583,GO:0048584,GO:0048666,GO:0048699,GO:0048707,GO:0048729,GO:0048731,GO:0048736,GO:0048737,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051301,GO:0051716,GO:0060429,GO:0060562,GO:0060828,GO:0061640,GO:0065007,GO:0070011,GO:0070536,GO:0070646,GO:0070647,GO:0070848,GO:0070887,GO:0071108,GO:0071310,GO:0071363,GO:0071495,GO:0071695,GO:0071704,GO:0071840,GO:0071944,GO:0090263,GO:0097447,GO:0097458,GO:0097708,GO:0098588,GO:0098794,GO:0098805,GO:0098984,GO:0099572,GO:0101005,GO:0120025,GO:0120038,GO:0140096,GO:1901564,GO:1903047,GO:1990089,GO:1990090	3.4.19.12	ko:K11839	ko04137,ko04144,ko04934,map04137,map04144,map04934	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04121,ko04131	-	-	-	Rhodanese,UCH,USP8_dimer
TLS2_k127_740597_15	1232429.CBLL010000169_gene947	4.881e-44	183.0	COG2951@1|root,COG2951@2|Bacteria,2GX49@201174|Actinobacteria,1WCDI@1268|Micrococcaceae	201174|Actinobacteria	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT,SLT_2
TLS2_k127_740597_10	1394178.AWOO02000072_gene443	2.011e-94	317.0	COG1024@1|root,COG1024@2|Bacteria,2GKC4@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_740597_7	298654.FraEuI1c_5630	1.559e-115	395.0	COG0277@1|root,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria,4ESN2@85013|Frankiales	201174|Actinobacteria	C	PFAM FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_740597_9	1894.JOER01000002_gene3502	1.414e-95	319.0	COG0584@1|root,COG0584@2|Bacteria,2GJ5W@201174|Actinobacteria	201174|Actinobacteria	C	glycerophosphoryl diester phosphodiesterase	glpQ2	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS2_k127_740597_0	58123.JOFJ01000013_gene4952	2.394e-202	643.0	COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,4EIDS@85012|Streptosporangiales	201174|Actinobacteria	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_740597_1	1313172.YM304_25510	5.152e-170	544.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4CNFE@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_740597_13	1968.JOEV01000036_gene1269	2.511e-45	185.0	COG0406@1|root,COG0406@2|Bacteria,2GM22@201174|Actinobacteria	201174|Actinobacteria	G	Phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
TLS2_k127_740597_3	1229780.BN381_50094	2.942e-165	533.0	COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria,3UW6V@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Pyruvate kinase, barrel domain	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
TLS2_k127_740597_14	1229780.BN381_410037	6.119e-45	167.0	2DMMI@1|root,32SFN@2|Bacteria,2IKP6@201174|Actinobacteria,3UXKS@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Protein of unknown function (DUF3151)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3151
TLS2_k127_740597_19	1121918.ARWE01000001_gene2717	3.96e-10	70.0	COG0746@1|root,COG1763@1|root,COG0746@2|Bacteria,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,42RZK@68525|delta/epsilon subdivisions,2WQ3C@28221|Deltaproteobacteria,43SFT@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobB	-	2.7.7.77	ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
TLS2_k127_740597_16	65497.JODV01000005_gene1036	1.448e-18	93.0	COG0607@1|root,COG0607@2|Bacteria,2IQIP@201174|Actinobacteria,4E5IE@85010|Pseudonocardiales	201174|Actinobacteria	P	Rhodanese-related sulfurtransferase	glpE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_740597_8	1313172.YM304_20250	1.294e-111	374.0	COG0349@1|root,COG0349@2|Bacteria,2GKNM@201174|Actinobacteria,4CN02@84992|Acidimicrobiia	84992|Acidimicrobiia	J	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
TLS2_k127_740597_17	580340.Tlie_0171	6.344e-18	94.0	COG0730@1|root,COG0730@2|Bacteria,3TCIF@508458|Synergistetes	508458|Synergistetes	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_7408871_9	1206743.BAGM01000199_gene975	2.02e-28	119.0	COG2272@1|root,COG2272@2|Bacteria,2GJCN@201174|Actinobacteria,4G5Z2@85025|Nocardiaceae	201174|Actinobacteria	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
TLS2_k127_7408871_4	1120972.AUMH01000006_gene1809	1.372e-55	206.0	COG0657@1|root,COG0657@2|Bacteria,1UWRG@1239|Firmicutes,4I9QW@91061|Bacilli,27AB6@186823|Alicyclobacillaceae	91061|Bacilli	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS2_k127_7408871_8	1370121.AUWS01000031_gene2698	7.578e-31	134.0	COG0583@1|root,COG0583@2|Bacteria,2GJ4Z@201174|Actinobacteria,235GA@1762|Mycobacteriaceae	201174|Actinobacteria	K	LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_7408871_1	1229780.BN381_150105	3.496e-149	483.0	COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,3UW7B@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Ammonium Transporter Family	amt	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	iNJ661.Rv2920c	Ammonium_transp
TLS2_k127_7408871_6	1123258.AQXZ01000019_gene2736	3.877e-45	168.0	COG0347@1|root,COG0347@2|Bacteria,2IKN1@201174|Actinobacteria,4G17M@85025|Nocardiaceae	201174|Actinobacteria	K	nitrogen regulatory protein P-II	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
TLS2_k127_7408871_11	713586.KB900536_gene1970	9.455e-19	93.0	2DRHB@1|root,33BRG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7408871_10	1313172.YM304_34610	7.338e-27	111.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria	201174|Actinobacteria	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_7408871_0	298653.Franean1_7031	2.332e-157	541.0	COG2199@1|root,COG2199@2|Bacteria,2IIAD@201174|Actinobacteria,4EVKT@85013|Frankiales	201174|Actinobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9
TLS2_k127_7408871_3	1449068.JMLQ01000005_gene3378	2.871e-66	238.0	COG1305@1|root,COG1305@2|Bacteria,2GMD7@201174|Actinobacteria,4FXDT@85025|Nocardiaceae	201174|Actinobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
TLS2_k127_7408871_2	1333998.M2A_2493	2.84e-147	477.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,4BTBG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_7408871_5	1333998.M2A_2494	6.68e-46	180.0	2EXDM@1|root,33QQ7@2|Bacteria,1NTQ6@1224|Proteobacteria,2UQVJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7408871_7	1229780.BN381_640028	4.484e-31	131.0	COG1309@1|root,COG1309@2|Bacteria,2HGC2@201174|Actinobacteria,3UXKK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_764546_23	479435.Kfla_5629	3.005e-72	263.0	COG0842@1|root,COG0842@2|Bacteria,2GMXR@201174|Actinobacteria,4DNU1@85009|Propionibacteriales	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
TLS2_k127_764546_30	1120950.KB892756_gene6690	2.154e-56	210.0	COG0842@1|root,COG0842@2|Bacteria,2GVC2@201174|Actinobacteria,4DQNH@85009|Propionibacteriales	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
TLS2_k127_764546_9	1306174.JODP01000016_gene7221	6.346e-123	411.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	nodI	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
TLS2_k127_764546_46	446471.Xcel_0284	6.181e-07	61.0	2DZHZ@1|root,32VB7@2|Bacteria,2GPY2@201174|Actinobacteria,4F5J4@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_764546_38	379066.GAU_0013	1.62e-33	147.0	COG0204@1|root,COG0204@2|Bacteria,1ZUGT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TLS2_k127_764546_43	1229780.BN381_780007	5.488e-19	96.0	2CAFG@1|root,32RRB@2|Bacteria,2IQ98@201174|Actinobacteria,3UXT2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Protein of unknown function (DUF3039)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3039
TLS2_k127_764546_44	240302.BN982_01523	1.964e-17	87.0	COG1950@1|root,COG1950@2|Bacteria,1VF4I@1239|Firmicutes,4HNXP@91061|Bacilli,3NF7S@45667|Halobacillus	91061|Bacilli	S	Mycobacterial 4 TMS phage holin, superfamily IV	yvlD	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
TLS2_k127_764546_7	631362.Thi970DRAFT_04130	3.108e-133	462.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RRQC@1236|Gammaproteobacteria,1WX34@135613|Chromatiales	135613|Chromatiales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	BLUF,EAL,GGDEF,PAS,PAS_9,Peripla_BP_6
TLS2_k127_764546_22	1313172.YM304_26870	8.787e-73	251.0	COG1435@1|root,COG1435@2|Bacteria,2GP1W@201174|Actinobacteria	201174|Actinobacteria	F	Thymidine kinase	tdk	GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
TLS2_k127_764546_26	1229780.BN381_80337	1.948e-63	222.0	COG1329@1|root,COG1329@2|Bacteria,2GKSU@201174|Actinobacteria,3UWUR@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
TLS2_k127_764546_20	1089544.KB912942_gene1783	4.066e-75	262.0	COG1073@1|root,COG1073@2|Bacteria,2IFI1@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_764546_34	1440774.Y900_018995	6.822e-38	164.0	COG2199@1|root,COG2199@2|Bacteria,2IE9F@201174|Actinobacteria,23FGI@1762|Mycobacteriaceae	201174|Actinobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9
TLS2_k127_764546_32	1313172.YM304_19810	1.111e-47	192.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria,4CN8S@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3048) C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
TLS2_k127_764546_37	1121017.AUFG01000004_gene3296	2.749e-34	143.0	COG1295@1|root,COG1295@2|Bacteria,2GM6P@201174|Actinobacteria,4FFN0@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_764546_1	1229780.BN381_300026	3.418e-200	641.0	COG1960@1|root,COG1960@2|Bacteria,2GJIB@201174|Actinobacteria,3UX2A@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Acyl-CoA dehydrogenase N terminal	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
TLS2_k127_764546_16	1463854.JOHT01000004_gene928	7.582e-88	300.0	COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria	201174|Actinobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	-	-	-	-	-	-	-	-	-	LGT
TLS2_k127_764546_36	665577.JH993790_gene5277	2.121e-34	145.0	COG3173@1|root,COG3173@2|Bacteria,2GS95@201174|Actinobacteria	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_764546_17	1003195.SCAT_1488	9.651e-79	274.0	COG1680@1|root,COG1680@2|Bacteria,2GNVX@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	bla	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_764546_35	1313172.YM304_07560	1.085e-34	139.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
TLS2_k127_764546_24	1120950.KB892743_gene3129	1.765e-68	239.0	COG0386@1|root,COG0386@2|Bacteria,2IFJH@201174|Actinobacteria,4DQMK@85009|Propionibacteriales	201174|Actinobacteria	O	Glutathione peroxidase	gpx	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
TLS2_k127_764546_5	1229780.BN381_80340	1.393e-148	481.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,3UW8N@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
TLS2_k127_764546_47	1385520.N802_18470	7.975e-05	52.0	COG4961@1|root,COG4961@2|Bacteria,2GWMA@201174|Actinobacteria,4FI0B@85021|Intrasporangiaceae	201174|Actinobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS2_k127_764546_19	2045.KR76_15495	1.511e-77	278.0	COG0827@1|root,COG0827@2|Bacteria,2HZT5@201174|Actinobacteria,4DSQJ@85009|Propionibacteriales	201174|Actinobacteria	L	N-6 DNA Methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
TLS2_k127_764546_41	1476583.DEIPH_ctg052orf0087	2.432e-25	119.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	hrtB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02004,ko:K09813	ko02010,map02010	M00257,M00258	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_764546_13	1313172.YM304_38290	9.379e-97	336.0	COG0577@1|root,COG0577@2|Bacteria,2GMC4@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type antimicrobial peptide transport system, permease component	hrtB	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_764546_15	1313172.YM304_38280	1.911e-91	324.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CNT1@84992|Acidimicrobiia	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_764546_0	450851.PHZ_c2065	5.409e-206	654.0	COG0318@1|root,COG0318@2|Bacteria,1MVJ1@1224|Proteobacteria,2TUQ9@28211|Alphaproteobacteria,2KIBE@204458|Caulobacterales	204458|Caulobacterales	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.42	ko:K18688	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_764546_4	1313172.YM304_23840	1.549e-156	509.0	COG2021@1|root,COG2021@2|Bacteria,2GKNJ@201174|Actinobacteria,4CNHB@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metX	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_764546_3	1229780.BN381_80350	6.525e-168	540.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,3UX88@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	megL	-	2.5.1.48,2.5.1.49,4.4.1.11	ko:K01739,ko:K01740,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01287,R01288,R02508,R03217,R03260,R04770,R04859,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02821,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS2_k127_764546_12	1463895.JODA01000001_gene204	6.758e-97	326.0	COG4977@1|root,COG4977@2|Bacteria,2GIRA@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
TLS2_k127_764546_39	324057.Pjdr2_0668	1.242e-31	132.0	COG0607@1|root,COG0607@2|Bacteria,1VYAE@1239|Firmicutes,4HXM9@91061|Bacilli,275RR@186822|Paenibacillaceae	91061|Bacilli	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_764546_11	1229780.BN381_290030	2.983e-115	391.0	COG2230@1|root,COG2230@2|Bacteria,2IA12@201174|Actinobacteria	201174|Actinobacteria	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS2_k127_764546_10	391008.Smal_1954	4.776e-118	395.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1X2ZB@135614|Xanthomonadales	135614|Xanthomonadales	M	synthase	cfaA	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS2_k127_764546_31	384676.PSEEN2703	1.821e-49	192.0	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,1S6FD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
TLS2_k127_764546_8	330214.NIDE0210	4.328e-127	425.0	COG2907@1|root,COG2907@2|Bacteria	2|Bacteria	S	Flavin containing amine oxidoreductase	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
TLS2_k127_764546_21	1229780.BN381_80351	1.045e-73	256.0	COG0266@1|root,COG0266@2|Bacteria,2H39J@201174|Actinobacteria	201174|Actinobacteria	L	formamidopyrimidine-DNA glycosylase	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_764546_42	1121877.JQKF01000027_gene2453	4.576e-24	103.0	2ANAN@1|root,31D8Y@2|Bacteria,2HGVW@201174|Actinobacteria,4CNX0@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_764546_18	690850.Desaf_0523	1.08e-78	273.0	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,42SYY@68525|delta/epsilon subdivisions,2WPKZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_764546_6	936455.KI421499_gene4835	8.083e-144	468.0	COG0654@1|root,COG0654@2|Bacteria,1MXEW@1224|Proteobacteria,2TRRC@28211|Alphaproteobacteria,3JV1F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	MA20_42420	-	1.14.13.218	ko:K20940	ko00405,ko01130,map00405,map01130	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
TLS2_k127_764546_40	864051.BurJ1DRAFT_0556	3.39e-30	130.0	2DMP1@1|root,32SS8@2|Bacteria,1N0XZ@1224|Proteobacteria,2VRVN@28216|Betaproteobacteria,1KNKI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF3237)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3237
TLS2_k127_764546_27	1313172.YM304_17930	4.869e-60	214.0	COG3576@1|root,COG3576@2|Bacteria,2H5HQ@201174|Actinobacteria	201174|Actinobacteria	L	pyridoxamine 5-phosphate	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
TLS2_k127_764546_33	222534.KB893717_gene2005	9.438e-42	167.0	2C7TJ@1|root,31RF6@2|Bacteria,2GP9X@201174|Actinobacteria,4EWEW@85013|Frankiales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	5.2.1.4	ko:K16163	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R03868	RC00867	ko00000,ko00001,ko01000	-	-	-	MDMPI_C,MDMPI_N
TLS2_k127_764546_29	1313172.YM304_16580	5.109e-59	213.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
TLS2_k127_764546_28	331869.BAL199_10055	1.458e-59	229.0	COG1024@1|root,COG1024@2|Bacteria,1MWGT@1224|Proteobacteria,2TV7F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	MA20_40055	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_764546_45	1283299.AUKG01000004_gene1115	3.234e-07	59.0	2AXJB@1|root,31PJD@2|Bacteria,2HRXN@201174|Actinobacteria,4CU0X@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_764546_25	469383.Cwoe_1098	3.553e-65	226.0	COG4119@1|root,COG4119@2|Bacteria,2IM6D@201174|Actinobacteria,4CTE0@84995|Rubrobacteria	84995|Rubrobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_764546_14	479435.Kfla_6159	3.306e-94	343.0	COG0477@1|root,COG2814@2|Bacteria,2H0CW@201174|Actinobacteria,4DN0M@85009|Propionibacteriales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_764546_2	1206744.BAGL01000071_gene3382	1.088e-187	602.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4FYNR@85025|Nocardiaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS2_k127_80215_13	1116232.AHBF01000143_gene9526	3.198e-20	100.0	COG4585@1|root,COG4585@2|Bacteria,2IKJN@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
TLS2_k127_80215_1	713587.THITH_11260	6.215e-308	970.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS2_k127_80215_4	1894.JOER01000011_gene2035	1.066e-157	506.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase	dapC	-	2.6.1.1,2.6.1.17,2.6.1.2,2.6.1.66	ko:K00812,ko:K14260,ko:K14267	ko00220,ko00250,ko00270,ko00290,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016	R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R04475,R05052	RC00006,RC00008,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_80215_17	1894.JOER01000003_gene2748	7.088e-14	79.0	COG5592@1|root,COG5592@2|Bacteria,2IJ0S@201174|Actinobacteria	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin,Rho_N
TLS2_k127_80215_7	682795.AciX8_3876	2.155e-63	227.0	COG3393@1|root,COG3393@2|Bacteria	2|Bacteria	S	Acetyltransferase (GNAT) family	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,FR47
TLS2_k127_80215_11	329726.AM1_2005	1.106e-38	158.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	yjjG	GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006206,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008655,GO:0009058,GO:0009112,GO:0009410,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019856,GO:0019859,GO:0030145,GO:0034641,GO:0034654,GO:0042221,GO:0042578,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.3.102,3.1.3.104,3.1.3.5,3.8.1.2	ko:K01560,ko:K07025,ko:K08723,ko:K20862	ko00230,ko00240,ko00361,ko00625,ko00740,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00740,map00760,map01100,map01110,map01120	M00125	R00183,R00511,R00548,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R05287,R07280	RC00017,RC00697	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_4614	HAD_2
TLS2_k127_80215_16	196490.AUEZ01000064_gene1471	1.708e-16	87.0	COG4803@1|root,COG4803@2|Bacteria,1RAJ2@1224|Proteobacteria,2U6M7@28211|Alphaproteobacteria,3JU96@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
TLS2_k127_80215_2	867845.KI911784_gene1528	3.232e-278	888.0	COG0296@1|root,COG0296@2|Bacteria,2G5IR@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TLS2_k127_80215_5	477974.Daud_0866	5.135e-111	387.0	COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia,2610T@186807|Peptococcaceae	186801|Clostridia	G	PFAM glycoside hydrolase family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
TLS2_k127_80215_0	479434.Sthe_1092	0.0	1283.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia	189775|Thermomicrobia	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
TLS2_k127_80215_3	76114.ebA7002	7.929e-245	773.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,2VK9R@28216|Betaproteobacteria,2KYHA@206389|Rhodocyclales	206389|Rhodocyclales	F	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	-	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	DUF3416
TLS2_k127_80215_9	926569.ANT_25430	6.441e-48	198.0	COG2335@1|root,COG2335@2|Bacteria,2G7AJ@200795|Chloroflexi	200795|Chloroflexi	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
TLS2_k127_80215_12	929712.KI912613_gene2333	3.325e-25	110.0	COG3427@1|root,COG3427@2|Bacteria	2|Bacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	COXG,Polyketide_cyc2
TLS2_k127_80215_6	1229780.BN381_80207	1.014e-72	254.0	COG3336@1|root,COG3336@2|Bacteria	2|Bacteria	G	cytochrome c oxidase	ctaG	-	-	ko:K02351,ko:K02862	-	-	-	-	ko00000	-	-	-	Caa3_CtaG
TLS2_k127_80215_14	1245471.PCA10_26630	4.457e-20	100.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MVYW@1224|Proteobacteria,1RY2R@1236|Gammaproteobacteria,1YIYE@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Cytochrome C oxidase subunit II, periplasmic domain	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
TLS2_k127_80215_15	745310.G432_02475	2.349e-18	93.0	COG2847@1|root,COG2847@2|Bacteria,1N3BG@1224|Proteobacteria,2UM57@28211|Alphaproteobacteria,2K60Y@204457|Sphingomonadales	204457|Sphingomonadales	S	Copper chaperone PCu(A)C	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
TLS2_k127_80215_8	1229780.BN381_80208	1.638e-52	195.0	COG1999@1|root,COG2847@1|root,COG1999@2|Bacteria,COG2847@2|Bacteria,2GKF0@201174|Actinobacteria	201174|Actinobacteria	S	SCO1 SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
TLS2_k127_80215_10	1229780.BN381_140018	1.455e-41	161.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	-	-	3.6.1.13,5.4.2.12	ko:K01515,ko:K15634	ko00010,ko00230,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00230,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01054,R01518	RC00002,RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
TLS2_k127_89763_0	1211815.CBYP010000067_gene124	7.114e-181	584.0	COG0747@1|root,COG0747@2|Bacteria,2ID29@201174|Actinobacteria,4EX5B@85013|Frankiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
TLS2_k127_89763_1	1211815.CBYP010000067_gene124	2.879e-176	572.0	COG0747@1|root,COG0747@2|Bacteria,2ID29@201174|Actinobacteria,4EX5B@85013|Frankiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
TLS2_k127_89763_2	1146883.BLASA_2836	4.147e-99	334.0	COG0601@1|root,COG0601@2|Bacteria,2GK0Z@201174|Actinobacteria,4ETSM@85013|Frankiales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_89763_3	1146883.BLASA_2835	1.285e-96	326.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4EX5A@85013|Frankiales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_89763_4	1313172.YM304_35360	8.835e-40	158.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	nudL	GO:0003674,GO:0003824,GO:0016787,GO:0016817,GO:0016818	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_93898_7	512565.AMIS_18580	1.966e-113	402.0	COG3903@1|root,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
TLS2_k127_93898_10	1487953.JMKF01000095_gene5153	1.59e-79	275.0	COG0426@1|root,COG0426@2|Bacteria	2|Bacteria	C	nitric oxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_93898_14	1246995.AFR_38285	4.077e-23	114.0	COG4899@1|root,COG4899@2|Bacteria,2IHJM@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2199)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2199
TLS2_k127_93898_12	656024.FsymDg_3335	5.205e-55	206.0	COG3327@1|root,COG3327@2|Bacteria,2GNME@201174|Actinobacteria,4EU5Y@85013|Frankiales	201174|Actinobacteria	K	PaaX-like protein	-	-	-	ko:K02616	-	-	-	-	ko00000,ko03000	-	-	-	PaaX,PaaX_C
TLS2_k127_93898_9	1123269.NX02_17600	1.009e-89	309.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TR6X@28211|Alphaproteobacteria,2K3RN@204457|Sphingomonadales	204457|Sphingomonadales	C	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_93898_4	1122918.KB907249_gene3906	1.061e-145	472.0	COG2124@1|root,COG2124@2|Bacteria,1TPWZ@1239|Firmicutes,4HAGS@91061|Bacilli,26V2H@186822|Paenibacillaceae	91061|Bacilli	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_93898_3	103733.JNYO01000039_gene4524	4.849e-153	496.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4E0VY@85010|Pseudonocardiales	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_93898_2	1123269.NX02_13580	8.196e-161	537.0	COG1775@1|root,COG1775@2|Bacteria,1R4FZ@1224|Proteobacteria,2U405@28211|Alphaproteobacteria,2K3JG@204457|Sphingomonadales	204457|Sphingomonadales	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
TLS2_k127_93898_11	882083.SacmaDRAFT_2539	1.193e-64	235.0	COG1840@1|root,COG1840@2|Bacteria	2|Bacteria	P	iron ion homeostasis	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_11,SBP_bac_6,SBP_bac_8
TLS2_k127_93898_0	882083.SacmaDRAFT_2540	3.696e-201	644.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria,4EAXP@85010|Pseudonocardiales	201174|Actinobacteria	P	ABC-type Fe3 transport system, permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1,SBP_bac_6
TLS2_k127_93898_6	882083.SacmaDRAFT_2541	2.363e-117	413.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4E93C@85010|Pseudonocardiales	201174|Actinobacteria	E	ABC transporter	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
TLS2_k127_93898_13	935866.JAER01000005_gene90	3.067e-40	171.0	COG0346@1|root,COG0346@2|Bacteria,2I9G1@201174|Actinobacteria,4DRCB@85009|Propionibacteriales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_93898_5	1313172.YM304_41110	2.094e-128	442.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4CMW3@84992|Acidimicrobiia	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
TLS2_k127_93898_1	1313172.YM304_41100	2.883e-183	584.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria,4CNGY@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Glycosyl hydrolase family 1	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
TLS2_k127_93898_8	1313172.YM304_41090	7.05e-102	343.0	COG1609@1|root,COG1609@2|Bacteria,2GJV7@201174|Actinobacteria,4CNIK@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_942381_2	1289387.AUKW01000009_gene4242	1.678e-164	532.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_942381_0	2074.JNYD01000022_gene1437	9.641e-231	750.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4DXJW@85010|Pseudonocardiales	201174|Actinobacteria	K	transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,Trans_reg_C
TLS2_k127_942381_3	43759.JNWK01000009_gene4886	1.916e-117	395.0	COG0654@1|root,COG0654@2|Bacteria,2GK7I@201174|Actinobacteria	201174|Actinobacteria	CH	tryptophan 2,3-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_942381_1	861299.J421_1936	4.554e-227	719.0	COG3158@1|root,COG3158@2|Bacteria,1ZTCK@142182|Gemmatimonadetes	2|Bacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
TLS2_k127_947242_7	1313172.YM304_19740	1.501e-15	79.0	2F9Q3@1|root,34209@2|Bacteria,2H616@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_947242_5	1313172.YM304_19730	1.266e-56	203.0	COG0537@1|root,COG0537@2|Bacteria,2GJT5@201174|Actinobacteria,4CN4U@84992|Acidimicrobiia	84992|Acidimicrobiia	FG	HIT domain	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
TLS2_k127_947242_0	1298863.AUEP01000008_gene1089	1.335e-240	760.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4DN38@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
TLS2_k127_947242_2	1229780.BN381_50170	8.054e-94	317.0	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria,3UWK8@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Phosphate acyltransferases	plsC2	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_947242_1	43759.JNWK01000078_gene3992	5.691e-214	675.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria	201174|Actinobacteria	GM	Nad-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
TLS2_k127_947242_4	649638.Trad_1784	2.426e-74	261.0	2A1VH@1|root,30Q4S@2|Bacteria,1WMIG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_947242_3	710696.Intca_0409	8.682e-83	280.0	COG0739@1|root,COG0739@2|Bacteria,2I9IY@201174|Actinobacteria,4FGTD@85021|Intrasporangiaceae	201174|Actinobacteria	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_947242_6	1229780.BN381_50169	3.889e-19	88.0	COG0215@1|root,COG0215@2|Bacteria,2GJZR@201174|Actinobacteria,3UX20@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	tRNA synthetases class I (C) catalytic domain	mshC	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1e
TLS2_k127_967096_2	1313172.YM304_19290	2.328e-76	267.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4CNR5@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
TLS2_k127_967096_4	1229780.BN381_140026	8.315e-50	186.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	MA20_41050	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
TLS2_k127_967096_3	1236902.ANAS01000013_gene1353	2.346e-69	254.0	COG0483@1|root,COG0483@2|Bacteria,2GJQE@201174|Actinobacteria,4EG2I@85012|Streptosporangiales	201174|Actinobacteria	G	Inositol monophosphatase family	suhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043167,GO:0043169,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS2_k127_967096_0	1313172.YM304_19260	4.964e-117	381.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4CMYH@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_967096_1	1313172.YM304_19250	9.803e-108	375.0	COG0642@1|root,COG2205@2|Bacteria,2GK1J@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
## 3024 queries scanned
## Total time (seconds): 22.432963132858276
## Rate: 134.80 q/s