## Thu Feb 19 19:09:05 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/TLS2_bin.69.fa -m mmseqs --output TLS2_bin.69 --output_dir /data/result/bins/wyx/eggqs50+/TLS2_bin.69 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TLS2_k127_100452_3	479435.Kfla_2563	3.078e-80	271.0	299E4@1|root,2ZWGX@2|Bacteria,2GM90@201174|Actinobacteria,4DQ7U@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF3145)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3145
TLS2_k127_100452_0	1463879.JOHP01000007_gene591	1.937e-288	893.0	COG0033@1|root,COG0033@2|Bacteria,2H1PI@201174|Actinobacteria	201174|Actinobacteria	G	Phosphoglucomutase	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_100452_1	1120950.KB892749_gene3356	5.987e-124	416.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4DNKT@85009|Propionibacteriales	201174|Actinobacteria	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1,APH
TLS2_k127_100452_2	44060.JODL01000020_gene4891	2.202e-94	315.0	COG0604@1|root,COG0604@2|Bacteria,2GIWC@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
TLS2_k127_1013275_5	1210045.ALNP01000009_gene4741	2.793e-121	396.0	COG0107@1|root,COG0107@2|Bacteria,2GIRP@201174|Actinobacteria	201174|Actinobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007	4.1.3.27	ko:K01657,ko:K02500	ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023,M00026	R00985,R00986,R04558	RC00010,RC01190,RC01943,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS2_k127_1013275_13	471852.Tcur_2891	7.419e-48	181.0	COG0251@1|root,COG0251@2|Bacteria,2IIB2@201174|Actinobacteria,4EJGT@85012|Streptosporangiales	201174|Actinobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS2_k127_1013275_6	469371.Tbis_1438	8.427e-117	391.0	COG0106@1|root,COG0106@2|Bacteria,2GJ4V@201174|Actinobacteria,4DZTD@85010|Pseudonocardiales	201174|Actinobacteria	E	imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16,5.3.1.24	ko:K01814,ko:K01817	ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230	M00023,M00026	R03509,R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS2_k127_1013275_7	935866.JAER01000003_gene1348	8.897e-97	323.0	COG0118@1|root,COG0118@2|Bacteria,2GIYS@201174|Actinobacteria,4DPJU@85009|Propionibacteriales	201174|Actinobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS2_k127_1013275_8	479435.Kfla_2921	3.561e-95	318.0	COG0131@1|root,COG0131@2|Bacteria,2GKMD@201174|Actinobacteria,4DNSZ@85009|Propionibacteriales	201174|Actinobacteria	E	Imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,4.2.1.19	ko:K01089,ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013,R03457	RC00017,RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
TLS2_k127_1013275_3	1120950.KB892707_gene4910	1.471e-160	519.0	COG0079@1|root,COG0079@2|Bacteria,2GJ9W@201174|Actinobacteria,4DPP5@85009|Propionibacteriales	201174|Actinobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_1013275_2	749414.SBI_07907	7.86e-202	637.0	COG0141@1|root,COG0141@2|Bacteria,2GKKA@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
TLS2_k127_1013275_11	479433.Caci_5731	1.843e-58	211.0	COG2802@1|root,COG2802@2|Bacteria,2GNWA@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase S16, lon domain protein	-	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
TLS2_k127_1013275_10	1101188.KI912155_gene2889	1.501e-64	225.0	COG2606@1|root,COG2606@2|Bacteria,2IHS8@201174|Actinobacteria,1W9EP@1268|Micrococcaceae	201174|Actinobacteria	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
TLS2_k127_1013275_15	1429046.RR21198_0406	6.391e-38	145.0	2BB91@1|root,324RQ@2|Bacteria,2H9PI@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1013275_17	55952.BU52_23880	1.029e-15	86.0	2EGQJ@1|root,33AGQ@2|Bacteria,2IHWM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2567
TLS2_k127_1013275_0	1121017.AUFG01000014_gene2013	0.0	1747.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4FE3D@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA-directed DNA polymerase	dnaE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS2_k127_1013275_9	479432.Sros_2890	7.03e-69	246.0	COG1605@1|root,COG2876@1|root,COG1605@2|Bacteria,COG2876@2|Bacteria,2IJ0D@201174|Actinobacteria,4EJRB@85012|Streptosporangiales	201174|Actinobacteria	E	Chorismate mutase type II	-	-	-	-	-	-	-	-	-	-	-	-	CM_2,DAHP_synth_1
TLS2_k127_1013275_4	1123322.KB904652_gene574	1.433e-146	479.0	COG0564@1|root,COG0564@2|Bacteria,2GIY1@201174|Actinobacteria	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_1013275_14	106370.Francci3_1425	1.154e-42	166.0	COG0597@1|root,COG0597@2|Bacteria,2GKRX@201174|Actinobacteria,4ET0T@85013|Frankiales	201174|Actinobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	GO:0006464,GO:0006497,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0019538,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044419,GO:0051704,GO:0071704,GO:1901564,GO:1901566,GO:1901576	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
TLS2_k127_1013275_12	196162.Noca_3054	1.275e-51	194.0	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4DR4Q@85009|Propionibacteriales	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
TLS2_k127_1013275_16	590998.Celf_1125	1.036e-22	101.0	COG1872@1|root,COG1872@2|Bacteria,2GQSC@201174|Actinobacteria	201174|Actinobacteria	EGP	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
TLS2_k127_1013275_1	1123320.KB889675_gene3844	0.0	1383.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
TLS2_k127_1016008_10	1232429.CBLL010000104_gene323	1.217e-08	62.0	28KX4@1|root,2ZAD4@2|Bacteria,2I8V3@201174|Actinobacteria,1WAKR@1268|Micrococcaceae	201174|Actinobacteria	S	Protein of unknown function (Hypoth_ymh)	-	-	-	-	-	-	-	-	-	-	-	-	Hypoth_Ymh
TLS2_k127_1016008_8	67352.JODS01000051_gene2671	1.343e-25	110.0	28KX4@1|root,2ZAD4@2|Bacteria,2I8V3@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (Hypoth_ymh)	-	-	-	-	-	-	-	-	-	-	-	-	Hypoth_Ymh
TLS2_k127_1016008_9	1150864.MILUP08_41735	2.467e-12	70.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4D8SX@85008|Micromonosporales	201174|Actinobacteria	V	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_1016008_3	35754.JNYJ01000009_gene1953	6.302e-126	443.0	COG0457@1|root,COG3629@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3903@2|Bacteria,2H3FC@201174|Actinobacteria	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
TLS2_k127_1016008_2	264732.Moth_1785	1.079e-126	420.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,42EY1@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.11,2.6.1.17,2.6.1.82	ko:K00821,ko:K09251	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R01155,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_1016008_7	1449346.JQMO01000002_gene346	1.153e-57	211.0	COG3689@1|root,COG3689@2|Bacteria,2GZEU@201174|Actinobacteria	201174|Actinobacteria	S	TIGRFAM TIGR03943 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1980
TLS2_k127_1016008_4	1463887.KL589971_gene4547	1.233e-117	388.0	COG0701@1|root,COG0701@2|Bacteria,2GJQ0@201174|Actinobacteria	201174|Actinobacteria	P	permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
TLS2_k127_1016008_6	1449355.JQNR01000004_gene1954	1.138e-72	256.0	COG0451@1|root,COG0451@2|Bacteria,2GP01@201174|Actinobacteria	201174|Actinobacteria	GM	epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_1016008_1	1048339.KB913029_gene4786	2.3e-130	434.0	COG0020@1|root,COG0020@2|Bacteria,2GIXF@201174|Actinobacteria,4ERUY@85013|Frankiales	201174|Actinobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.86,2.5.1.88	ko:K00806,ko:K14215,ko:K21273	ko00900,ko01110,map00900,map01110	-	R06447,R09244,R09731	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS2_k127_1016008_5	1304865.JAGF01000001_gene2887	1.028e-111	365.0	COG1381@1|root,COG1381@2|Bacteria,2GK81@201174|Actinobacteria,4F0NV@85016|Cellulomonadaceae	201174|Actinobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
TLS2_k127_1016008_0	110319.CF8_1602	1.796e-174	552.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,4DU7Y@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS2_k127_1019127_2	1123320.KB889675_gene3890	4.843e-20	93.0	COG3200@1|root,COG3200@2|Bacteria,2GJBX@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the class-II DAHP synthase family	aroG	GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016043,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0022607,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.5.1.54	ko:K01626,ko:K16019	ko00400,ko01051,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01051,map01100,map01110,map01130,map01230,map02024	M00022	R01826,R06591	RC00435,RC01556	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2178c	DAHP_synth_2
TLS2_k127_1019127_1	367299.JOEE01000001_gene1827	2.22e-198	625.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4FG41@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.90	ko:K00895	ko00010,ko00030,ko00051,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map01100,map01110,map01120,map01130	-	R00764,R02073	RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
TLS2_k127_1019127_0	1380356.JNIK01000020_gene1326	1.42e-204	646.0	COG0367@1|root,COG0367@2|Bacteria,2GJIM@201174|Actinobacteria,4ERY2@85013|Frankiales	201174|Actinobacteria	E	asparagine	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
TLS2_k127_1021237_9	1463895.JODA01000014_gene1502	3.877e-11	75.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
TLS2_k127_1021237_3	479432.Sros_9341	5.947e-141	454.0	COG2207@1|root,COG2207@2|Bacteria,2GK7Q@201174|Actinobacteria,4EGPW@85012|Streptosporangiales	201174|Actinobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
TLS2_k127_1021237_7	1449069.JMLO01000019_gene2791	1.525e-42	161.0	COG3467@1|root,COG3467@2|Bacteria,2IQIK@201174|Actinobacteria,4G30K@85025|Nocardiaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_1021237_2	1120950.KB892779_gene930	5.61e-143	471.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4DRAS@85009|Propionibacteriales	201174|Actinobacteria	C	Proton-conducting membrane transporter	nuoN2	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_1021237_0	1120950.KB892779_gene931	1.152e-187	630.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4DN4B@85009|Propionibacteriales	201174|Actinobacteria	C	Proton-conducting membrane transporter	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_1021237_1	1120950.KB892779_gene932	2.248e-175	580.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4DT5U@85009|Propionibacteriales	201174|Actinobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL2	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TLS2_k127_1021237_8	1463934.JOCF01000001_gene6947	6.719e-34	144.0	COG0713@1|root,COG0713@2|Bacteria,2IHNW@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK2	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS2_k127_1021237_6	1120950.KB892779_gene934	1.579e-55	202.0	COG0839@1|root,COG0839@2|Bacteria,2GJB7@201174|Actinobacteria,4DV5E@85009|Propionibacteriales	201174|Actinobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	nuoJ2	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS2_k127_1021237_5	1463856.JOHY01000030_gene2876	6.865e-88	297.0	COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI2	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
TLS2_k127_1021237_4	1120950.KB892779_gene936	4.599e-131	422.0	COG1005@1|root,COG1005@2|Bacteria,2GN3R@201174|Actinobacteria,4DU89@85009|Propionibacteriales	201174|Actinobacteria	C	NADH dehydrogenase	nuoH2	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS2_k127_1029944_14	1463845.JOIG01000004_gene4013	4.9e-08	59.0	2E4C2@1|root,32Z7M@2|Bacteria,2IFS5@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3093)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3093
TLS2_k127_1029944_7	58344.JOEL01000090_gene1193	4.966e-62	222.0	COG2050@1|root,COG2050@2|Bacteria,2GKY1@201174|Actinobacteria	201174|Actinobacteria	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_1029944_8	1123320.KB889707_gene7998	9.582e-61	227.0	COG0756@1|root,COG0756@2|Bacteria,2IHYY@201174|Actinobacteria	201174|Actinobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
TLS2_k127_1029944_11	1120950.KB892748_gene3213	8.03e-50	191.0	28J4D@1|root,2Z90C@2|Bacteria,2GJYC@201174|Actinobacteria,4DRVJ@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF3710)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3710
TLS2_k127_1029944_12	1288079.AUKN01000013_gene1565	6.421e-41	154.0	COG1200@1|root,COG1200@2|Bacteria,2IHRX@201174|Actinobacteria	201174|Actinobacteria	KL	Nucleic acid binding, OB-fold, tRNA	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1029944_10	1122939.ATUD01000005_gene2787	2.827e-57	214.0	2AVV0@1|root,31MNQ@2|Bacteria,2GJKP@201174|Actinobacteria,4CSVZ@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function (DUF3159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3159
TLS2_k127_1029944_5	479435.Kfla_3762	4.01e-108	361.0	COG0569@1|root,COG0569@2|Bacteria,2GKB9@201174|Actinobacteria,4DN0P@85009|Propionibacteriales	201174|Actinobacteria	P	TrkA-C domain	ceoC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS2_k127_1029944_6	1122138.AQUZ01000029_gene4817	3.215e-98	327.0	COG0569@1|root,COG0569@2|Bacteria,2GK4N@201174|Actinobacteria,4DNXX@85009|Propionibacteriales	201174|Actinobacteria	P	TrkA-N domain	ceoB	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS2_k127_1029944_1	1146883.BLASA_3288	2.855e-248	783.0	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,4ERRM@85013|Frankiales	201174|Actinobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
TLS2_k127_1029944_2	2002.JOEQ01000014_gene5322	1.196e-141	476.0	COG2265@1|root,COG2265@2|Bacteria,2GIR3@201174|Actinobacteria,4EG7S@85012|Streptosporangiales	201174|Actinobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
TLS2_k127_1029944_0	1120950.KB892748_gene3229	0.0	1506.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4DPP4@85009|Propionibacteriales	201174|Actinobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS2_k127_1029944_13	1146883.BLASA_3285	1.575e-36	141.0	2E8DB@1|root,332RT@2|Bacteria,2IHS0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1029944_3	1306174.JODP01000006_gene3403	5.021e-133	447.0	COG4213@1|root,COG4213@2|Bacteria,2GKRE@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter substrate-binding protein	xylF	-	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
TLS2_k127_1029944_4	1306174.JODP01000013_gene7763	2.024e-117	386.0	COG1129@1|root,COG1129@2|Bacteria,2GJDV@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter	-	-	3.6.3.17	ko:K10545	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4	-	-	ABC_tran
TLS2_k127_1029944_9	1150864.MILUP08_46226	6.021e-59	211.0	COG4214@1|root,COG4214@2|Bacteria,2GJAH@201174|Actinobacteria,4DB7Z@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10544	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	BPD_transp_2
TLS2_k127_1030135_2	1120950.KB892747_gene3664	9.646e-112	370.0	COG0329@1|root,COG0329@2|Bacteria,2GJ34@201174|Actinobacteria,4DNA0@85009|Propionibacteriales	201174|Actinobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008840,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_1030135_1	1095767.CAHD01000224_gene2103	6.495e-277	864.0	COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,4F0MZ@85016|Cellulomonadaceae	201174|Actinobacteria	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
TLS2_k127_1030135_0	1122609.AUGT01000002_gene3861	0.0	1034.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,4DN14@85009|Propionibacteriales	201174|Actinobacteria	D	Ftsk_gamma	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TLS2_k127_1030135_3	408672.NBCG_01518	1.19e-36	145.0	COG0621@1|root,COG0621@2|Bacteria,2GKRI@201174|Actinobacteria,4DNHY@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
TLS2_k127_103279_3	1120950.KB892775_gene1207	2.759e-135	437.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4DNF2@85009|Propionibacteriales	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	1.8.3.1	ko:K00387	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00533	RC00168	ko00000,ko00001,ko01000	-	-	-	Oxidored_molyb
TLS2_k127_103279_19	479435.Kfla_1742	6.929e-17	90.0	COG3296@1|root,COG3296@2|Bacteria,2GT71@201174|Actinobacteria,4DSEG@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1707,DUF4870
TLS2_k127_103279_11	1415166.NONO_c62170	1.359e-65	251.0	COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,4FVR7@85025|Nocardiaceae	201174|Actinobacteria	O	Redoxin	bcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS2_k127_103279_8	2002.JOEQ01000041_gene5996	3.823e-97	338.0	COG0310@1|root,COG0310@2|Bacteria,2GK2U@201174|Actinobacteria,4EH5Z@85012|Streptosporangiales	201174|Actinobacteria	P	Cobalt uptake substrate-specific transmembrane region	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
TLS2_k127_103279_7	1169161.KB897724_gene4928	1.203e-97	325.0	COG0619@1|root,COG0619@2|Bacteria,2GKQ7@201174|Actinobacteria	201174|Actinobacteria	P	Cobalt ABC transporter	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
TLS2_k127_103279_5	469371.Tbis_0515	5.47e-117	396.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4DYPQ@85010|Pseudonocardiales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	cbiO	-	-	ko:K02006,ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
TLS2_k127_103279_21	1033730.CAHG01000015_gene721	4.304e-09	62.0	2DYK7@1|root,34A68@2|Bacteria,2HZGV@201174|Actinobacteria,4DSRQ@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF3618)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3618
TLS2_k127_103279_14	585531.HMPREF0063_11071	2.748e-57	212.0	COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria,4DSWR@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
TLS2_k127_103279_15	479435.Kfla_1859	3.887e-47	175.0	COG0234@1|root,COG0234@2|Bacteria,2IHRC@201174|Actinobacteria,4DR8F@85009|Propionibacteriales	201174|Actinobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groES2	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TLS2_k127_103279_4	266940.Krad_3754	1.82e-124	413.0	COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome P450	cyp132	-	-	ko:K21164	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002	-	-	-	p450
TLS2_k127_103279_9	1120950.KB892709_gene4080	4.289e-97	330.0	COG4129@1|root,COG4129@2|Bacteria,2GIR7@201174|Actinobacteria,4DNGI@85009|Propionibacteriales	201174|Actinobacteria	S	Fusaric acid resistance protein-like	-	-	-	-	-	-	-	-	-	-	-	-	FUSC_2
TLS2_k127_103279_6	1048339.KB913029_gene2913	8.556e-106	364.0	COG3285@1|root,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria,4ES9N@85013|Frankiales	201174|Actinobacteria	L	DNA polymerase LigD, polymerase domain	ligD	GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS2_k127_103279_10	1120950.KB892823_gene523	1.55e-87	314.0	COG2120@1|root,COG2120@2|Bacteria,2GKUM@201174|Actinobacteria,4DN6S@85009|Propionibacteriales	201174|Actinobacteria	S	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway	mshB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016020,GO:0016137,GO:0016138,GO:0016787,GO:0016810,GO:0016811,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	3.5.1.103	ko:K15525	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_103279_12	1380390.JIAT01000009_gene2063	1.574e-65	248.0	COG0697@1|root,COG0697@2|Bacteria,2GMPJ@201174|Actinobacteria,4CQ3D@84995|Rubrobacteria	84995|Rubrobacteria	EG	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
TLS2_k127_103279_16	1380390.JIAT01000009_gene2064	7.499e-37	147.0	COG1802@1|root,COG1802@2|Bacteria,2HQT3@201174|Actinobacteria,4CSHV@84995|Rubrobacteria	84995|Rubrobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_103279_13	1194165.CAJF01000023_gene3158	3.585e-60	221.0	COG0739@1|root,COG0739@2|Bacteria,2I9IY@201174|Actinobacteria	201174|Actinobacteria	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_103279_17	1385519.N801_08230	1.113e-21	100.0	COG4978@1|root,COG4978@2|Bacteria,2IS9W@201174|Actinobacteria,4FHRK@85021|Intrasporangiaceae	201174|Actinobacteria	KT	family transcriptional regulator	-	-	-	ko:K13652	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18
TLS2_k127_103279_1	390989.JOEG01000014_gene3137	1.751e-171	543.0	COG1741@1|root,COG1741@2|Bacteria,2GIY9@201174|Actinobacteria,4D9FR@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
TLS2_k127_103279_20	1463901.JOIY01000034_gene7249	2.847e-11	69.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
TLS2_k127_103279_2	675635.Psed_4299	4.662e-169	539.0	COG2223@1|root,COG2223@2|Bacteria,2GJ1I@201174|Actinobacteria,4DY3F@85010|Pseudonocardiales	201174|Actinobacteria	P	PFAM Major Facilitator Superfamily	narK2	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1,Sugar_tr
TLS2_k127_103279_18	1246445.ANAY01000014_gene218	1.815e-19	101.0	COG2345@1|root,COG2345@2|Bacteria,2IAWJ@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_IclR
TLS2_k127_103279_0	479431.Namu_0900	4.69e-291	909.0	COG5013@1|root,COG5013@2|Bacteria,2GKZU@201174|Actinobacteria,4ERXX@85013|Frankiales	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narG	GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008940,GO:0009056,GO:0009628,GO:0009987,GO:0010035,GO:0010167,GO:0016020,GO:0016491,GO:0016661,GO:0030312,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036293,GO:0036294,GO:0042126,GO:0042128,GO:0042221,GO:0042493,GO:0043436,GO:0043602,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070482,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071453,GO:0071704,GO:0071731,GO:0071732,GO:0071941,GO:0071944,GO:0097366,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:2001057	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding
TLS2_k127_1062015_8	521393.JH806632_gene721	2.093e-91	304.0	COG0549@1|root,COG0549@2|Bacteria,2HWQ6@201174|Actinobacteria,4D37Y@85005|Actinomycetales	201174|Actinobacteria	E	carbamate kinase	arcC	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS2_k127_1062015_5	1048339.KB913029_gene3939	5.879e-125	410.0	COG0217@1|root,COG0217@2|Bacteria,2GJ4G@201174|Actinobacteria,4ES5T@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TLS2_k127_1062015_10	471852.Tcur_2107	3.4e-83	281.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4EH1T@85012|Streptosporangiales	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
TLS2_k127_1062015_17	68170.KL590491_gene4849	3.285e-20	104.0	2EBG9@1|root,335GU@2|Bacteria,2IJZI@201174|Actinobacteria,4E4HK@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S30AE
TLS2_k127_1062015_2	1122611.KB904007_gene7809	7.086e-161	511.0	COG0214@1|root,COG0214@2|Bacteria,2GK1T@201174|Actinobacteria,4EG5S@85012|Streptosporangiales	201174|Actinobacteria	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
TLS2_k127_1062015_14	1120950.KB892708_gene4268	7.779e-49	190.0	COG1704@1|root,COG1704@2|Bacteria,2GK54@201174|Actinobacteria	201174|Actinobacteria	L	nUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	LemA
TLS2_k127_1062015_3	1120950.KB892708_gene4267	6.072e-148	495.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,4DNV1@85009|Propionibacteriales	201174|Actinobacteria	M	Glycosyltransferase Family 4	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
TLS2_k127_1062015_7	105422.BBPM01000032_gene3626	4.915e-95	328.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,2NF22@228398|Streptacidiphilus	201174|Actinobacteria	M	Bacterial lipid A biosynthesis acyltransferase	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
TLS2_k127_1062015_11	1121385.AQXW01000004_gene1077	1.878e-81	276.0	COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,1ZVWU@145357|Dermacoccaceae	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.11,2.7.8.5	ko:K00995,ko:K00999	ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070	-	R01801,R01802	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_1062015_0	1120950.KB892708_gene4264	0.0	1059.0	COG0480@1|root,COG0480@2|Bacteria,2GKRU@201174|Actinobacteria,4DNXI@85009|Propionibacteriales	201174|Actinobacteria	J	Elongation factor G, domain IV	fusA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_1062015_6	1123320.KB889665_gene1374	2.174e-111	385.0	COG3387@1|root,COG3387@2|Bacteria,2ICV9@201174|Actinobacteria	201174|Actinobacteria	G	Glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1062015_12	1123023.JIAI01000006_gene455	2.01e-74	256.0	COG0537@1|root,COG0537@2|Bacteria,2GJT5@201174|Actinobacteria,4DYSQ@85010|Pseudonocardiales	201174|Actinobacteria	FG	HIT family hydrolase, diadenosine tetraphosphate hydrolase	-	GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
TLS2_k127_1062015_1	1120950.KB892708_gene4256	0.0	1049.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4DN38@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
TLS2_k127_1062015_16	1123322.KB904647_gene1669	1.374e-24	117.0	COG0530@1|root,COG0530@2|Bacteria	2|Bacteria	P	calcium, potassium:sodium antiporter activity	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
TLS2_k127_1062015_15	1120950.KB892708_gene4235	1.575e-29	130.0	arCOG03175@1|root,32RFA@2|Bacteria,2IFE3@201174|Actinobacteria,4DS5J@85009|Propionibacteriales	201174|Actinobacteria	S	Streptomyces sporulation and cell division protein, SsgA	ssgB	GO:0000003,GO:0000910,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006725,GO:0006732,GO:0007049,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009653,GO:0009987,GO:0010564,GO:0010927,GO:0016043,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0018130,GO:0018958,GO:0019438,GO:0019748,GO:0019752,GO:0019954,GO:0022402,GO:0022607,GO:0030154,GO:0030312,GO:0030428,GO:0030435,GO:0030436,GO:0030447,GO:0030448,GO:0030638,GO:0030639,GO:0031160,GO:0032465,GO:0032467,GO:0032502,GO:0032506,GO:0032989,GO:0032991,GO:0040007,GO:0042180,GO:0042181,GO:0042221,GO:0042244,GO:0042546,GO:0043436,GO:0043648,GO:0043650,GO:0043934,GO:0043936,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044457,GO:0044464,GO:0044550,GO:0045229,GO:0045787,GO:0046189,GO:0046394,GO:0046483,GO:0048518,GO:0048522,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051188,GO:0051301,GO:0051302,GO:0051716,GO:0051726,GO:0051781,GO:0065007,GO:0070590,GO:0070726,GO:0070887,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0090068,GO:0090529,GO:1901110,GO:1901112,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1902074,GO:1902075,GO:1903664,GO:1903666,GO:1990586,GO:2000241,GO:2000243,GO:2000244,GO:2000246	-	-	-	-	-	-	-	-	-	-	SsgA
TLS2_k127_1062015_13	471852.Tcur_2620	3.681e-68	237.0	COG5516@1|root,COG5516@2|Bacteria,2GNZF@201174|Actinobacteria,4EIZW@85012|Streptosporangiales	201174|Actinobacteria	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
TLS2_k127_1062015_9	44060.JODL01000006_gene1436	3.189e-90	320.0	COG0115@1|root,COG0115@2|Bacteria,2GN5Z@201174|Actinobacteria	201174|Actinobacteria	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS2_k127_1062015_4	105425.BBPL01000007_gene7325	2.495e-133	433.0	COG0147@1|root,COG0147@2|Bacteria,2GN7D@201174|Actinobacteria,2NFE8@228398|Streptacidiphilus	201174|Actinobacteria	EH	chorismate binding enzyme	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4,Chorismate_bind
TLS2_k127_1062015_18	1120945.ATUW01000005_gene623	1.288e-07	54.0	2ASDQ@1|root,31HT6@2|Bacteria,2HMBW@201174|Actinobacteria,4D6R3@85005|Actinomycetales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_110011_6	235985.BBPN01000021_gene6267	5.319e-30	121.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,2NFN3@228398|Streptacidiphilus	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_110011_2	1440053.JOEI01000004_gene3800	7.924e-80	273.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_110011_5	1121946.AUAX01000022_gene3788	3.79e-36	153.0	COG4585@1|root,COG4585@2|Bacteria,2GQQ8@201174|Actinobacteria,4DCUS@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_110011_3	219305.MCAG_03578	4.638e-57	207.0	COG0572@1|root,COG0572@2|Bacteria,2GM18@201174|Actinobacteria,4DG0N@85008|Micromonosporales	201174|Actinobacteria	F	ATP-binding protein	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
TLS2_k127_110011_1	110319.CF8_2544	3.257e-87	302.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4DQY1@85009|Propionibacteriales	201174|Actinobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
TLS2_k127_110011_7	1463895.JODA01000062_gene6152	1.44e-28	124.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_22,BTAD,Trans_reg_C
TLS2_k127_110011_4	1043493.BBLU01000015_gene1172	1.222e-49	196.0	COG1266@1|root,COG1266@2|Bacteria,2GREE@201174|Actinobacteria	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS2_k127_110011_0	1380356.JNIK01000015_gene2339	1.824e-114	390.0	COG4425@1|root,COG4425@2|Bacteria,2GKB5@201174|Actinobacteria,4EU50@85013|Frankiales	201174|Actinobacteria	S	Alpha/beta-hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_9,Abhydrolase_9_N
TLS2_k127_110011_10	408672.NBCG_05538	1.203e-05	57.0	COG1846@1|root,COG1846@2|Bacteria,2IMA9@201174|Actinobacteria,4DRHW@85009|Propionibacteriales	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	MarR
TLS2_k127_110011_9	2074.JNYD01000005_gene3238	5.438e-09	59.0	COG1524@1|root,COG1524@2|Bacteria,2HH0Q@201174|Actinobacteria	201174|Actinobacteria	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_4_2,Phosphodiest
TLS2_k127_110011_11	1120949.KB903328_gene8822	1.908e-05	57.0	COG1524@1|root,COG1524@2|Bacteria,2HH0Q@201174|Actinobacteria,4DAQP@85008|Micromonosporales	201174|Actinobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_4_2,Phosphodiest
TLS2_k127_1126811_4	1123320.KB889640_gene4460	4.339e-146	469.0	COG0388@1|root,COG0388@2|Bacteria,2GKRJ@201174|Actinobacteria	201174|Actinobacteria	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS2_k127_1126811_2	1306174.JODP01000006_gene2997	2.961e-255	806.0	COG0438@1|root,COG1413@1|root,COG0438@2|Bacteria,COG1413@2|Bacteria,2HMNV@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1,HEAT_2
TLS2_k127_1126811_3	479431.Namu_4823	2.69e-175	559.0	COG1819@1|root,COG1819@2|Bacteria,2GJN7@201174|Actinobacteria,4EWK9@85013|Frankiales	201174|Actinobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0009058,GO:0009247,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0020012,GO:0030682,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044464,GO:0046467,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,UDPGT
TLS2_k127_1126811_1	1380356.JNIK01000006_gene1434	4.625e-316	989.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4ERWZ@85013|Frankiales	201174|Actinobacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	hyuA	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
TLS2_k127_1126811_0	471857.Svir_20950	0.0	1005.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4E23T@85010|Pseudonocardiales	201174|Actinobacteria	EQ	PFAM Hydantoinase B oxoprolinase	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
TLS2_k127_1157344_13	469383.Cwoe_3826	1.057e-70	244.0	COG2197@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria	201174|Actinobacteria	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HD_5
TLS2_k127_1157344_9	1206726.BAFV01000118_gene5813	1.793e-107	363.0	COG0500@1|root,COG0500@2|Bacteria,2I3GX@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_1157344_20	1125863.JAFN01000001_gene2091	8.827e-08	63.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31,rRNA_methylase
TLS2_k127_1157344_14	1123322.KB904667_gene3780	1.265e-41	170.0	COG0477@1|root,COG0477@2|Bacteria,2GJ9D@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_1157344_11	2055.JNXA01000022_gene3809	9.058e-72	257.0	COG0500@1|root,COG2226@2|Bacteria,2GM2N@201174|Actinobacteria,4GFQQ@85026|Gordoniaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_1157344_3	675635.Psed_5849	1.063e-214	693.0	COG0644@1|root,COG0644@2|Bacteria,2HZIE@201174|Actinobacteria,4EBY4@85010|Pseudonocardiales	201174|Actinobacteria	C	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1157344_0	675635.Psed_5850	7.971e-315	1004.0	COG0457@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,2GKKQ@201174|Actinobacteria,4DYP0@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Trans_reg_C
TLS2_k127_1157344_1	1120950.KB892707_gene4745	3.874e-281	869.0	COG0174@1|root,COG0174@2|Bacteria,2GMN1@201174|Actinobacteria,4DNAS@85009|Propionibacteriales	201174|Actinobacteria	E	glutamine synthetase	glnA	GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS2_k127_1157344_17	1120950.KB892707_gene4746	4.617e-32	130.0	COG1714@1|root,COG1714@2|Bacteria,2IQMG@201174|Actinobacteria,4DSWX@85009|Propionibacteriales	201174|Actinobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS2_k127_1157344_8	479431.Namu_0250	1.019e-116	396.0	COG3648@1|root,COG3648@2|Bacteria,2GK7W@201174|Actinobacteria,4ETS9@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin	-	-	1.7.3.3	ko:K00365	ko00230,ko00232,ko01100,ko01120,map00230,map00232,map01100,map01120	M00546	R02106,R07981	RC02107,RC02551	ko00000,ko00001,ko00002,ko01000	-	-	-	Uricase
TLS2_k127_1157344_18	1001240.GY21_04995	8.335e-31	133.0	COG2351@1|root,COG2351@2|Bacteria,2IQUN@201174|Actinobacteria,4FPMM@85023|Microbacteriaceae	201174|Actinobacteria	S	Transthyretin	uraH	-	3.5.2.17	ko:K07127	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06601	RC03393	ko00000,ko00001,ko00002,ko01000,ko02000	9.B.35.1.2,9.B.35.2	-	-	Transthyretin
TLS2_k127_1157344_16	1435356.Y013_22680	1.087e-34	139.0	COG3195@1|root,COG3195@2|Bacteria,2GKIP@201174|Actinobacteria,4G2NT@85025|Nocardiaceae	201174|Actinobacteria	S	OHCU decarboxylase	-	-	4.1.1.97	ko:K16840	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06604	RC01551	ko00000,ko00001,ko00002,ko01000	-	-	-	OHCU_decarbox
TLS2_k127_1157344_4	469371.Tbis_2590	3.461e-189	601.0	COG0044@1|root,COG0044@2|Bacteria,2IAM1@201174|Actinobacteria,4DXSN@85010|Pseudonocardiales	201174|Actinobacteria	F	Amidohydrolase family	allB	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.5	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02425	RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS2_k127_1157344_6	1123023.JIAI01000013_gene3898	4.372e-167	535.0	COG4266@1|root,COG4266@2|Bacteria,2GJ1V@201174|Actinobacteria,4DXW3@85010|Pseudonocardiales	201174|Actinobacteria	F	Belongs to the allantoicase family	alc	-	3.5.3.4	ko:K01477	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02422	RC00379,RC00712	ko00000,ko00001,ko00002,ko01000	-	-	-	Allantoicase,OHCU_decarbox
TLS2_k127_1157344_12	1120950.KB892707_gene4748	1.352e-71	250.0	2AUFS@1|root,31K3Y@2|Bacteria,2GIXC@201174|Actinobacteria,4DQHR@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF4191)	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF4191
TLS2_k127_1157344_7	479432.Sros_5140	1.48e-135	449.0	COG1835@1|root,COG1835@2|Bacteria,2GN56@201174|Actinobacteria,4EGC5@85012|Streptosporangiales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS2_k127_1157344_5	935866.JAER01000011_gene2235	1.191e-169	542.0	COG0320@1|root,COG0320@2|Bacteria,2GKD4@201174|Actinobacteria,4DPBB@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
TLS2_k127_1157344_10	1123251.ATWM01000004_gene1961	7.897e-95	316.0	COG0321@1|root,COG0321@2|Bacteria,2GJIX@201174|Actinobacteria,4FFX5@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TLS2_k127_1157344_15	28444.JODQ01000009_gene3647	1.744e-35	140.0	COG1846@1|root,COG1846@2|Bacteria,2IQXC@201174|Actinobacteria,4EQX9@85012|Streptosporangiales	201174|Actinobacteria	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR,MarR_2
TLS2_k127_1157344_2	397278.JOJN01000007_gene3436	2.936e-230	733.0	COG2409@1|root,COG2409@2|Bacteria,2GIRQ@201174|Actinobacteria,4DNWE@85009|Propionibacteriales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_1157344_19	1156844.KB891820_gene72	2.084e-12	67.0	COG1232@1|root,COG1232@2|Bacteria	2|Bacteria	H	protoporphyrinogen oxidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS2_k127_1157619_5	1313172.YM304_21910	2.007e-33	139.0	COG1296@1|root,COG1296@2|Bacteria	2|Bacteria	E	L-valine transmembrane transporter activity	azlC	-	-	-	-	-	-	-	-	-	-	-	AzlC
TLS2_k127_1157619_4	404589.Anae109_4238	6.027e-45	174.0	COG2030@1|root,COG2030@2|Bacteria,1RJN8@1224|Proteobacteria	1224|Proteobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS2_k127_1157619_2	1265310.CCBD010000063_gene1175	2.08e-62	223.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,2IASU@201174|Actinobacteria,232Z7@1762|Mycobacteriaceae	201174|Actinobacteria	IT	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
TLS2_k127_1157619_0	1380393.JHVP01000003_gene1268	3.219e-154	501.0	COG1073@1|root,COG2114@1|root,COG1073@2|Bacteria,COG2114@2|Bacteria,2IASU@201174|Actinobacteria	201174|Actinobacteria	IT	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
TLS2_k127_1157619_1	1386089.N865_15100	1.127e-96	330.0	COG0654@1|root,COG0654@2|Bacteria,2I2TH@201174|Actinobacteria	201174|Actinobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS2_k127_1157619_6	675635.Psed_0242	9.684e-07	56.0	COG0425@1|root,COG0425@2|Bacteria,2GSNH@201174|Actinobacteria,4ED96@85010|Pseudonocardiales	201174|Actinobacteria	O	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS2_k127_1157619_3	494419.ALPM01000070_gene1689	3.981e-56	201.0	COG3271@1|root,COG3271@2|Bacteria,2H973@201174|Actinobacteria	201174|Actinobacteria	M	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I36,Transglycosylas,VCBS
TLS2_k127_1191705_2	1504319.GM45_1000	1.626e-125	407.0	COG1233@1|root,COG1233@2|Bacteria,2GJAV@201174|Actinobacteria,3UXB3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
TLS2_k127_1191705_1	266940.Krad_3227	4.736e-138	448.0	COG0142@1|root,COG0142@2|Bacteria,2GJEK@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_1191705_0	1120950.KB892707_gene4870	2.169e-142	463.0	COG0685@1|root,COG0685@2|Bacteria,2GJTN@201174|Actinobacteria,4DPM1@85009|Propionibacteriales	201174|Actinobacteria	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS2_k127_1191705_5	446469.Sked_30160	6.061e-35	142.0	COG2968@1|root,COG2968@2|Bacteria	2|Bacteria	S	cellular response to heat	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
TLS2_k127_1191705_4	326424.FRAAL2165	2.145e-61	218.0	COG0558@1|root,COG0558@2|Bacteria,2IDSP@201174|Actinobacteria,4ET6D@85013|Frankiales	201174|Actinobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_1191705_3	1380393.JHVP01000003_gene800	1.189e-101	343.0	COG2040@1|root,COG2040@2|Bacteria,2GIWK@201174|Actinobacteria,4EUZT@85013|Frankiales	201174|Actinobacteria	E	homocysteine S-methyltransferase	mmuM	-	2.1.1.10	ko:K00547,ko:K21169	ko00270,ko01059,ko01100,ko01110,ko01130,map00270,map01059,map01100,map01110,map01130	M00825	R00650	RC00003,RC00035	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
TLS2_k127_1201040_5	1095767.CAHD01000193_gene198	8.658e-142	458.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria	201174|Actinobacteria	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS2_k127_1201040_16	1380347.JNII01000006_gene1919	8.531e-24	116.0	COG2193@1|root,COG2193@2|Bacteria,2GJEI@201174|Actinobacteria,4ESV8@85013|Frankiales	201174|Actinobacteria	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TLS2_k127_1201040_13	419947.MRA_2658	1.651e-41	160.0	COG1371@1|root,COG1371@2|Bacteria,2IS0V@201174|Actinobacteria,23DM1@1762|Mycobacteriaceae	201174|Actinobacteria	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
TLS2_k127_1201040_14	1352941.M877_36605	2.404e-33	136.0	COG0375@1|root,COG0375@2|Bacteria,2IMJK@201174|Actinobacteria	201174|Actinobacteria	S	Hydrogenase nickel incorporation protein hypA	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
TLS2_k127_1201040_9	164757.Mjls_2132	3.768e-99	329.0	COG0378@1|root,COG0378@2|Bacteria,2HP34@201174|Actinobacteria,2349D@1762|Mycobacteriaceae	201174|Actinobacteria	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
TLS2_k127_1201040_2	1041522.MCOL_V221151	7.327e-227	704.0	COG1740@1|root,COG1740@2|Bacteria,2GKF2@201174|Actinobacteria,232BY@1762|Mycobacteriaceae	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase, 20	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
TLS2_k127_1201040_0	1944.JOAZ01000003_gene5167	0.0	1180.0	COG0374@1|root,COG0374@2|Bacteria,2GKQY@201174|Actinobacteria	201174|Actinobacteria	C	Large subunit	hydB	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
TLS2_k127_1201040_8	1352941.M877_36620	4.527e-108	358.0	COG0694@1|root,COG2146@1|root,COG0694@2|Bacteria,COG2146@2|Bacteria,2GKHD@201174|Actinobacteria	201174|Actinobacteria	O	PFAM nitrogen-fixing NifU domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NifU,Rieske
TLS2_k127_1201040_11	1352941.M877_36625	4.216e-91	313.0	2ADVU@1|root,313MT@2|Bacteria,2H7PH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1201040_10	1944.JOAZ01000003_gene5170	1.867e-91	314.0	29Z4R@1|root,30M2D@2|Bacteria,2GNPH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1201040_3	1352941.M877_36635	1.032e-164	529.0	COG0680@1|root,COG0680@2|Bacteria,2GKMU@201174|Actinobacteria	201174|Actinobacteria	C	Initiates the rapid degradation of small, acid-soluble proteins during spore germination	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1201040_12	1352941.M877_36650	4.535e-59	213.0	COG0680@1|root,COG0680@2|Bacteria,2GN48@201174|Actinobacteria	201174|Actinobacteria	C	TIGRFAM hydrogenase maturation protease	hupD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
TLS2_k127_1201040_15	1429046.RR21198_4160	1.369e-27	114.0	COG0298@1|root,COG0298@2|Bacteria,2IREM@201174|Actinobacteria,4G3I0@85025|Nocardiaceae	201174|Actinobacteria	O	HupF/HypC family	hypC1	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
TLS2_k127_1201040_7	1146883.BLASA_3057	1.319e-132	428.0	29JD5@1|root,306AN@2|Bacteria,2I9J8@201174|Actinobacteria,4EVHS@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1201040_4	1146883.BLASA_3056	5.872e-160	509.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4ES21@85013|Frankiales	201174|Actinobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
TLS2_k127_1201040_1	1146883.BLASA_3055	1.274e-233	734.0	COG1178@1|root,COG1178@2|Bacteria,2GKPT@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
TLS2_k127_1201040_6	1146883.BLASA_3054	9.543e-142	458.0	COG1840@1|root,COG1840@2|Bacteria	1146883.BLASA_3054|-	P	iron ion homeostasis	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	-
TLS2_k127_1201040_19	1502850.FG91_00704	2.316e-15	89.0	COG0454@1|root,COG0456@2|Bacteria,1N4JC@1224|Proteobacteria,2UCY3@28211|Alphaproteobacteria,2K4ZS@204457|Sphingomonadales	204457|Sphingomonadales	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
TLS2_k127_1227251_1	1048339.KB913029_gene4959	2.39e-190	608.0	COG1793@1|root,COG1793@2|Bacteria,2GJ2P@201174|Actinobacteria,4ERUG@85013|Frankiales	201174|Actinobacteria	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
TLS2_k127_1227251_5	675635.Psed_3901	4.516e-28	119.0	COG3339@1|root,COG3339@2|Bacteria,2GQGT@201174|Actinobacteria,4E6ZU@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
TLS2_k127_1227251_3	1123023.JIAI01000010_gene8480	2.043e-161	522.0	COG2897@1|root,COG2897@2|Bacteria,2GIYU@201174|Actinobacteria,4E0UA@85010|Pseudonocardiales	201174|Actinobacteria	P	Sulfurtransferase	sseA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS2_k127_1227251_4	1043205.AFYF01000004_gene1338	2.776e-55	199.0	COG2166@1|root,COG2166@2|Bacteria,2IMBF@201174|Actinobacteria,4FGIP@85021|Intrasporangiaceae	201174|Actinobacteria	S	Fe-S metabolism associated domain	sufE	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
TLS2_k127_1227251_0	1894.JOER01000027_gene4437	1.47e-288	903.0	COG0514@1|root,COG0514@2|Bacteria,2GJSS@201174|Actinobacteria	201174|Actinobacteria	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
TLS2_k127_1227251_2	35754.JNYJ01000021_gene493	1.289e-162	543.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4DGUJ@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,Trans_reg_C
TLS2_k127_1234121_1	1121933.AUHH01000028_gene1890	6.759e-158	522.0	COG2021@1|root,COG2021@2|Bacteria,2GKNJ@201174|Actinobacteria,4DNSW@85009|Propionibacteriales	201174|Actinobacteria	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metX	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_1234121_0	2045.KR76_18085	1.846e-222	701.0	COG2873@1|root,COG2873@2|Bacteria,2I2EB@201174|Actinobacteria,4DNVF@85009|Propionibacteriales	201174|Actinobacteria	E	O-acetylhomoserine	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
TLS2_k127_1266041_12	1032480.MLP_34630	1.051e-21	96.0	COG1555@1|root,COG1596@1|root,COG1555@2|Bacteria,COG1596@2|Bacteria,2IQDC@201174|Actinobacteria,4DRFZ@85009|Propionibacteriales	201174|Actinobacteria	L	Helix-hairpin-helix motif	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
TLS2_k127_1266041_2	1048339.KB913029_gene4829	2.074e-182	602.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4ES7C@85013|Frankiales	201174|Actinobacteria	S	ComEC Rec2-related protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
TLS2_k127_1266041_6	1123322.KB904724_gene1958	1.028e-94	320.0	COG1466@1|root,COG1466@2|Bacteria,2GNMZ@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
TLS2_k127_1266041_10	28444.JODQ01000001_gene2595	4.098e-25	109.0	COG0268@1|root,COG0268@2|Bacteria,2IQ73@201174|Actinobacteria,4EKBP@85012|Streptosporangiales	201174|Actinobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
TLS2_k127_1266041_8	1476876.JOJO01000042_gene8165	6.443e-54	215.0	COG2337@1|root,COG2337@2|Bacteria,2GM10@201174|Actinobacteria	201174|Actinobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PemK_toxin
TLS2_k127_1266041_0	1048339.KB913029_gene4817	0.0	1027.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4ERZ3@85013|Frankiales	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
TLS2_k127_1266041_7	585531.HMPREF0063_11256	9.745e-71	246.0	COG2258@1|root,COG2258@2|Bacteria,2GMCN@201174|Actinobacteria,4DQQW@85009|Propionibacteriales	201174|Actinobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
TLS2_k127_1266041_1	1122622.ATWJ01000007_gene1912	9.248e-236	743.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4FEHR@85021|Intrasporangiaceae	201174|Actinobacteria	I	AMP-dependent synthetase	fadD11_1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS2_k127_1266041_3	1120950.KB892739_gene4000	8.672e-182	588.0	COG0635@1|root,COG0635@2|Bacteria,2GJXX@201174|Actinobacteria,4DN32@85009|Propionibacteriales	201174|Actinobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	iNJ661.Rv2388c	HemN_C,Radical_SAM
TLS2_k127_1266041_11	1242864.D187_009930	1.318e-22	106.0	COG3296@1|root,COG3296@2|Bacteria,1N8TC@1224|Proteobacteria,42X1A@68525|delta/epsilon subdivisions,2WSRI@28221|Deltaproteobacteria,2Z1HZ@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4870)	-	-	-	ko:K09940	-	-	-	-	ko00000	-	-	-	DUF4870
TLS2_k127_1266041_9	1449976.KALB_1704	2.197e-35	145.0	COG1714@1|root,COG1714@2|Bacteria,2I15M@201174|Actinobacteria,4E2VZ@85010|Pseudonocardiales	201174|Actinobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS2_k127_1266041_13	1246448.ANAZ01000004_gene4749	4.287e-07	56.0	COG0613@1|root,COG0613@2|Bacteria,2GIZ5@201174|Actinobacteria,4EFY9@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF3097)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3097
TLS2_k127_1266041_5	1120950.KB892739_gene3996	9.557e-153	492.0	COG1420@1|root,COG1420@2|Bacteria,2GKF5@201174|Actinobacteria,4DP2Y@85009|Propionibacteriales	201174|Actinobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA
TLS2_k127_1266041_4	1288083.AUKR01000005_gene2195	5.52e-169	537.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_1294736_0	1157637.KB892155_gene7731	0.0	1517.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria	201174|Actinobacteria	E	Dehydrogenase	gdh	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
TLS2_k127_1294736_3	1122609.AUGT01000006_gene1438	1.124e-124	405.0	COG3483@1|root,COG3483@2|Bacteria,2GNB1@201174|Actinobacteria,4DN3M@85009|Propionibacteriales	201174|Actinobacteria	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
TLS2_k127_1294736_6	1386089.N865_13350	3.091e-29	124.0	COG3832@1|root,COG3832@2|Bacteria,2GS2W@201174|Actinobacteria,4FGK2@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2505)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2505
TLS2_k127_1294736_1	367299.JOEE01000003_gene2926	1.961e-275	858.0	COG1012@1|root,COG1012@2|Bacteria,2GJZE@201174|Actinobacteria,4FFQI@85021|Intrasporangiaceae	201174|Actinobacteria	C	Dehydrogenase	rocA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS2_k127_1294736_5	1394178.AWOO02000005_gene3627	4.841e-41	170.0	2DRWJ@1|root,32URV@2|Bacteria,2IFAY@201174|Actinobacteria,4EJ7U@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1294736_4	235985.BBPN01000026_gene1441	2.033e-86	304.0	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria,2NGGN@228398|Streptacidiphilus	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS2_k127_1294736_2	1120950.KB892764_gene5614	3.271e-161	516.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4DN7F@85009|Propionibacteriales	201174|Actinobacteria	Q	Belongs to the long-chain O-acyltransferase family	tgs3	GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
TLS2_k127_1315456_0	1380393.JHVP01000005_gene3598	1.002e-216	683.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria,4ETQ2@85013|Frankiales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
TLS2_k127_1315456_1	1380347.JNII01000006_gene1237	4.105e-155	498.0	COG0448@1|root,COG0448@2|Bacteria,2I2EF@201174|Actinobacteria,4EUQ3@85013|Frankiales	201174|Actinobacteria	G	Nucleotidyl transferase	-	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_1315456_4	1386089.N865_09825	8.787e-43	160.0	COG3832@1|root,COG3832@2|Bacteria,2ISSI@201174|Actinobacteria,4FGMQ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_1315456_3	1121946.AUAX01000007_gene3041	2.139e-50	188.0	2B8SK@1|root,3222I@2|Bacteria,2H6AX@201174|Actinobacteria,4DJPG@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1315456_2	1343740.M271_06180	1.814e-134	435.0	COG1595@1|root,COG1595@2|Bacteria,2GMRK@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
TLS2_k127_132179_3	547163.BN979_01571	3.912e-11	72.0	COG1211@1|root,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,233H1@1762|Mycobacteriaceae	201174|Actinobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
TLS2_k127_132179_0	1048339.KB913029_gene2036	3.848e-88	294.0	COG1329@1|root,COG1329@2|Bacteria,2GKSU@201174|Actinobacteria,4ES60@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulator, CarD family	carD	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
TLS2_k127_132179_1	1968.JOEV01000013_gene868	1.205e-62	234.0	COG0382@1|root,COG0382@2|Bacteria,2GJT3@201174|Actinobacteria	201174|Actinobacteria	H	Pfam UbiA prenyltransferase	ubiA	-	-	-	-	-	-	-	-	-	-	-	UbiA
TLS2_k127_132179_2	1121877.JQKF01000007_gene1026	9.848e-56	197.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4CMQN@84992|Acidimicrobiia	201174|Actinobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0375c	CO_deh_flav_C,FAD_binding_5
TLS2_k127_1354820_4	1032480.MLP_13070	7.121e-05	54.0	COG0739@1|root,COG3021@1|root,COG3409@1|root,COG0739@2|Bacteria,COG3021@2|Bacteria,COG3409@2|Bacteria,2IFNV@201174|Actinobacteria	201174|Actinobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,Peptidase_M23
TLS2_k127_1354820_3	483215.BACFIN_05030	8.806e-14	85.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia,4AKZ1@815|Bacteroidaceae	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,PDZ_2,Peptidase_S41,Tricorn_C1
TLS2_k127_1354820_1	543632.JOJL01000020_gene722	6.539e-61	232.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
TLS2_k127_1354820_0	479435.Kfla_6816	7.47e-102	338.0	COG1028@1|root,COG1028@2|Bacteria,2GKE1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_1354820_2	998674.ATTE01000001_gene3077	6.433e-35	146.0	296JA@1|root,2ZTUV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1372596_1	68170.KL590498_gene6753	2.481e-25	111.0	COG1309@1|root,COG1309@2|Bacteria,2GJQ1@201174|Actinobacteria,4E2CB@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
TLS2_k127_1372596_0	1122939.ATUD01000001_gene642	2.125e-84	296.0	COG2072@1|root,COG2072@2|Bacteria,2GMDH@201174|Actinobacteria,4CS42@84995|Rubrobacteria	84995|Rubrobacteria	P	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like
TLS2_k127_1372596_2	696747.NIES39_J02520	6.716e-19	94.0	COG4803@1|root,COG4803@2|Bacteria,1GA6S@1117|Cyanobacteria,1HEWV@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF1269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
TLS2_k127_1401970_9	1123320.KB889629_gene7840	2.28e-34	143.0	COG0629@1|root,COG0629@2|Bacteria,2GQIQ@201174|Actinobacteria	201174|Actinobacteria	L	single-stranded DNA-binding protein	ssb2	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_1401970_1	935839.JAGJ01000027_gene2799	3.08e-143	483.0	COG0699@1|root,COG0699@2|Bacteria,2GM68@201174|Actinobacteria,4F3TC@85017|Promicromonosporaceae	201174|Actinobacteria	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N,MMR_HSR1
TLS2_k127_1401970_0	1298863.AUEP01000005_gene2682	2.063e-188	604.0	COG0699@1|root,COG0699@2|Bacteria,2GJX9@201174|Actinobacteria,4DPB6@85009|Propionibacteriales	201174|Actinobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
TLS2_k127_1401970_4	743718.Isova_1407	3.149e-71	249.0	COG1881@1|root,COG1881@2|Bacteria,2GMIG@201174|Actinobacteria,4F5ID@85017|Promicromonosporaceae	201174|Actinobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
TLS2_k127_1401970_5	405948.SACE_6986	1.477e-65	229.0	COG2606@1|root,COG2606@2|Bacteria,2GKUX@201174|Actinobacteria,4E2QX@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM YbaK prolyl-tRNA synthetases associated domain	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
TLS2_k127_1401970_2	1123024.AUII01000002_gene1171	1.152e-89	317.0	COG2339@1|root,COG2339@2|Bacteria,2GKR5@201174|Actinobacteria,4DZMH@85010|Pseudonocardiales	201174|Actinobacteria	NU	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
TLS2_k127_1401970_3	1122138.AQUZ01000049_gene2368	2.988e-84	284.0	COG1949@1|root,COG1949@2|Bacteria,2GJR7@201174|Actinobacteria,4DPKU@85009|Propionibacteriales	201174|Actinobacteria	L	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
TLS2_k127_1401970_6	561175.KB894096_gene639	5.46e-57	210.0	COG5479@1|root,COG5479@2|Bacteria,2GMJR@201174|Actinobacteria,4EJ9Y@85012|Streptosporangiales	201174|Actinobacteria	M	Protein of unknown function (DUF3152)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3152
TLS2_k127_1401970_7	1380356.JNIK01000014_gene3357	3.407e-44	165.0	COG1145@1|root,32SB1@2|Bacteria,2IJFQ@201174|Actinobacteria,4ETJV@85013|Frankiales	201174|Actinobacteria	C	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF326
TLS2_k127_1401970_12	1463825.JNXC01000005_gene2397	4.869e-06	49.0	COG0582@1|root,COG0582@2|Bacteria,2IHIW@201174|Actinobacteria,4E2P0@85010|Pseudonocardiales	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
TLS2_k127_1401970_8	1283283.ATXA01000008_gene2984	2.289e-40	156.0	COG4974@1|root,COG4974@2|Bacteria,2ID5W@201174|Actinobacteria,4EWWQ@85013|Frankiales	201174|Actinobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
TLS2_k127_1419803_1	1048339.KB913029_gene4351	1.628e-88	295.0	COG0363@1|root,COG0363@2|Bacteria,2GMQ2@201174|Actinobacteria,4ESDZ@85013|Frankiales	201174|Actinobacteria	G	TIGRFAM 6-phosphogluconolactonase	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:1901135,GO:1901360,GO:1901564	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
TLS2_k127_1419803_2	1120948.KB903240_gene3903	1.737e-52	187.0	2CNY9@1|root,31GEE@2|Bacteria,2IKKZ@201174|Actinobacteria,4E4N7@85010|Pseudonocardiales	201174|Actinobacteria	K	Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters	rbpA	-	-	-	-	-	-	-	-	-	-	-	RbpA
TLS2_k127_1419803_3	110319.CF8_2155	4.081e-27	113.0	COG1314@1|root,COG1314@2|Bacteria,2GR31@201174|Actinobacteria,4DS3V@85009|Propionibacteriales	201174|Actinobacteria	U	Preprotein translocase SecG subunit	secG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
TLS2_k127_1419803_0	1449355.JQNR01000003_gene127	1.704e-118	388.0	COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria	201174|Actinobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TLS2_k127_1419803_4	656024.FsymDg_1698	1.581e-21	94.0	COG0126@1|root,COG0126@2|Bacteria,2GJC6@201174|Actinobacteria,4ES0I@85013|Frankiales	201174|Actinobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
TLS2_k127_1437184_11	593907.Celgi_0504	0.0009868	47.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4F0P0@85016|Cellulomonadaceae	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_1437184_1	404380.Gbem_0822	1.484e-270	867.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42P3J@68525|delta/epsilon subdivisions,2WKFS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS2_k127_1437184_0	1380356.JNIK01000015_gene2488	9.861e-319	1003.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4ERUT@85013|Frankiales	201174|Actinobacteria	G	hydrolase family 65, central catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase
TLS2_k127_1437184_9	196162.Noca_0284	1.264e-24	109.0	COG2905@1|root,COG2905@2|Bacteria,2GQMA@201174|Actinobacteria,4DWYP@85009|Propionibacteriales	201174|Actinobacteria	T	Domain of unknown function (DUF1918)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1918
TLS2_k127_1437184_5	1240349.ANGC01000006_gene1489	1.96e-132	428.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4FXQ8@85025|Nocardiaceae	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1437184_2	1240349.ANGC01000006_gene1488	3.433e-183	599.0	COG0842@1|root,COG0842@2|Bacteria,2GJ2G@201174|Actinobacteria,4G3B7@85025|Nocardiaceae	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_1437184_4	926560.KE387023_gene1701	5.733e-141	478.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,DUF3365,GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_1437184_6	926560.KE387023_gene1700	1.069e-104	360.0	COG3437@1|root,COG3852@1|root,COG3437@2|Bacteria,COG3852@2|Bacteria,1WMD2@1297|Deinococcus-Thermus	2|Bacteria	T	Histidine kinase-like ATPases	pleD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464	2.7.7.65,4.6.1.1	ko:K01768,ko:K02488,ko:K17763	ko00230,ko02020,ko02025,ko04112,ko04113,ko04213,map00230,map02020,map02025,map04112,map04113,map04213	M00511,M00695	R00089,R00434,R08057	RC00295	ko00000,ko00001,ko00002,ko01000,ko02022,ko03021	-	-	-	GGDEF,HATPase_c,HisKA,HisKA_3,PAS,PAS_9,Response_reg,cNMP_binding
TLS2_k127_1437184_3	251221.35211041	4.248e-181	583.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1FZX5@1117|Cyanobacteria	1117|Cyanobacteria	KOT	PFAM Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
TLS2_k127_1437184_7	263358.VAB18032_11715	1.528e-47	175.0	2AWFS@1|root,31NC1@2|Bacteria,2IMS0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_147401_6	67373.JOBF01000022_gene6585	2.807e-114	374.0	COG1637@1|root,COG1637@2|Bacteria,2GIYB@201174|Actinobacteria	201174|Actinobacteria	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
TLS2_k127_147401_11	103733.JNYO01000022_gene6899	5.686e-52	203.0	COG2203@1|root,COG2203@2|Bacteria,2GNWV@201174|Actinobacteria,4EDTQ@85010|Pseudonocardiales	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS2_k127_147401_1	1122138.AQUZ01000006_gene1310	2.003e-298	925.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4DMY4@85009|Propionibacteriales	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_147401_12	1120950.KB892745_gene2909	1.643e-34	135.0	2E3EP@1|root,32YDP@2|Bacteria,2GQST@201174|Actinobacteria,4DS23@85009|Propionibacteriales	201174|Actinobacteria	S	ATP- GTP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_147401_5	644283.Micau_5105	2.53e-123	400.0	COG2945@1|root,COG2945@2|Bacteria,2GP8G@201174|Actinobacteria,4DCBM@85008|Micromonosporales	201174|Actinobacteria	S	hydrolase of the alpha beta	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Abhydrolase_6
TLS2_k127_147401_8	1122611.KB903996_gene7554	5.859e-68	247.0	COG0596@1|root,COG0596@2|Bacteria,2GNFU@201174|Actinobacteria,4EFFN@85012|Streptosporangiales	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
TLS2_k127_147401_7	1394178.AWOO02000078_gene2009	2.311e-68	248.0	COG2268@1|root,COG2268@2|Bacteria,2GKTJ@201174|Actinobacteria,4EHSF@85012|Streptosporangiales	201174|Actinobacteria	S	DivIVA protein	abpS	-	-	-	-	-	-	-	-	-	-	-	DivIVA
TLS2_k127_147401_2	222534.KB893741_gene2881	2.188e-254	790.0	COG0604@1|root,COG0604@2|Bacteria,2GKFF@201174|Actinobacteria,4ERWW@85013|Frankiales	201174|Actinobacteria	C	TIGRFAM crotonyl-CoA reductase	-	-	1.3.1.86	ko:K17829	ko00650,ko01120,ko01130,ko01200,map00650,map01120,map01130,map01200	-	R09738	RC00076	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_147401_10	1210046.B277_14508	3.998e-63	221.0	COG0346@1|root,COG0346@2|Bacteria,2IIPR@201174|Actinobacteria,4FGBB@85021|Intrasporangiaceae	201174|Actinobacteria	E	methylmalonyl-CoA epimerase	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
TLS2_k127_147401_3	345341.KUTG_06459	8.65e-190	600.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4DYM7@85010|Pseudonocardiales	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_147401_4	196162.Noca_1798	9.991e-147	474.0	COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria,4DMZ6@85009|Propionibacteriales	201174|Actinobacteria	E	LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS2_k127_147401_15	479435.Kfla_4984	9.159e-05	48.0	295ZH@1|root,2ZTA9@2|Bacteria,2GWUF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_147401_14	110319.CF8_1463	5.428e-22	105.0	COG3428@1|root,COG3428@2|Bacteria,2IA1C@201174|Actinobacteria,4DR83@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
TLS2_k127_147401_9	469371.Tbis_0920	6.039e-65	237.0	COG1846@1|root,COG1846@2|Bacteria,2GKZA@201174|Actinobacteria,4DXV5@85010|Pseudonocardiales	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_147401_0	66874.JOFS01000024_gene1383	5.497e-307	947.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmA	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS2_k127_147401_13	1223523.H340_06556	3.004e-28	115.0	COG2350@1|root,COG2350@2|Bacteria,2GU13@201174|Actinobacteria	201174|Actinobacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
TLS2_k127_1482356_5	1121272.KB903249_gene2441	3.034e-73	252.0	COG0168@1|root,COG0168@2|Bacteria,2GKKS@201174|Actinobacteria,4D8QD@85008|Micromonosporales	201174|Actinobacteria	P	Cation transport protein	ktrB	-	-	-	-	-	-	-	-	-	-	-	TrkH
TLS2_k127_1482356_4	1217720.ALOX01000087_gene3028	1.165e-85	289.0	COG0569@1|root,COG0569@2|Bacteria,1R7KM@1224|Proteobacteria,2TY5D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0569 K transport systems, NAD-binding component	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS2_k127_1482356_0	1125971.ASJB01000067_gene4741	2.205e-158	522.0	COG4249@1|root,COG4249@2|Bacteria,2IAM3@201174|Actinobacteria,4E3RZ@85010|Pseudonocardiales	201174|Actinobacteria	O	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
TLS2_k127_1482356_8	1125971.ASJB01000067_gene4740	4.325e-32	130.0	2EQE3@1|root,33I03@2|Bacteria,2GTHD@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1482356_3	219305.MCAG_01458	5.531e-93	339.0	COG2273@1|root,COG2273@2|Bacteria,2GTJC@201174|Actinobacteria,4DJ0I@85008|Micromonosporales	201174|Actinobacteria	G	Glycosyl hydrolases family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
TLS2_k127_1482356_7	1120950.KB892801_gene1765	1.161e-37	149.0	COG0454@1|root,COG0456@2|Bacteria,2GQGN@201174|Actinobacteria,4DS9Y@85009|Propionibacteriales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_1482356_2	1122138.AQUZ01000014_gene7072	4.402e-125	404.0	COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria,4DNEJ@85009|Propionibacteriales	201174|Actinobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
TLS2_k127_1482356_1	397278.JOJN01000002_gene369	4.353e-127	420.0	COG0506@1|root,COG0506@2|Bacteria,2GJTK@201174|Actinobacteria,4DP4A@85009|Propionibacteriales	201174|Actinobacteria	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
TLS2_k127_1482356_6	1123320.KB889585_gene1844	1.599e-46	170.0	COG0842@1|root,COG0842@2|Bacteria,2GJ7Y@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K01990,ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_1487756_0	593907.Celgi_1139	0.0	1239.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4F0HT@85016|Cellulomonadaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TLS2_k127_1487756_1	1120950.KB892764_gene5601	2.506e-71	252.0	COG1670@1|root,COG1670@2|Bacteria,2GMDB@201174|Actinobacteria,4DQEE@85009|Propionibacteriales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_1493276_4	1120936.KB907210_gene5752	6.324e-58	215.0	COG2068@1|root,COG2068@2|Bacteria,2GK5R@201174|Actinobacteria,4EJ8B@85012|Streptosporangiales	201174|Actinobacteria	S	MobA-like NTP transferase domain	-	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TLS2_k127_1493276_0	1120936.KB907210_gene5753	8.912e-154	495.0	COG1975@1|root,COG1975@2|Bacteria,2GIZS@201174|Actinobacteria,4EIDG@85012|Streptosporangiales	201174|Actinobacteria	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS2_k127_1493276_2	1380347.JNII01000007_gene68	6.466e-108	374.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4ERVW@85013|Frankiales	201174|Actinobacteria	S	VWA containing CoxE family protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS2_k127_1493276_1	1394178.AWOO02000063_gene12	1.896e-125	424.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4EI63@85012|Streptosporangiales	201174|Actinobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
TLS2_k127_1493276_5	1158050.KB895452_gene675	6.396e-23	114.0	2BAAG@1|root,323QP@2|Bacteria,2H8F7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1493276_3	1298880.AUEV01000008_gene2436	1.812e-74	252.0	COG0040@1|root,COG0040@2|Bacteria,2GNAX@201174|Actinobacteria	201174|Actinobacteria	E	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
TLS2_k127_1501331_12	351607.Acel_1521	3.184e-116	385.0	COG3393@1|root,COG3393@2|Bacteria,2GMD2@201174|Actinobacteria,4ERYU@85013|Frankiales	201174|Actinobacteria	S	PFAM GCN5-related N-acetyltransferase	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,DUF4081,FR47
TLS2_k127_1501331_3	397278.JOJN01000001_gene2668	1.94e-218	682.0	COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,4DP7G@85009|Propionibacteriales	201174|Actinobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TLS2_k127_1501331_10	28444.JODQ01000016_gene7150	1.117e-159	514.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4EFKK@85012|Streptosporangiales	201174|Actinobacteria	M	Domain present in PSD-95, Dlg, and ZO-1/2.	rip1	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
TLS2_k127_1501331_6	1120950.KB892747_gene3725	7.736e-188	594.0	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria,4DND1@85009|Propionibacteriales	201174|Actinobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2870c	DXPR_C,DXP_redisom_C,DXP_reductoisom
TLS2_k127_1501331_2	367299.JOEE01000004_gene1213	1.171e-223	702.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FESA@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_1501331_7	1380347.JNII01000005_gene3136	1.834e-186	621.0	COG0160@1|root,COG0160@2|Bacteria,2GIS9@201174|Actinobacteria,4ERVR@85013|Frankiales	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_1501331_4	246196.MSMEI_6145	6.859e-213	666.0	COG1748@1|root,COG1748@2|Bacteria,2GMQ1@201174|Actinobacteria,233EG@1762|Mycobacteriaceae	201174|Actinobacteria	E	Saccharopine dehydrogenase	lys1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
TLS2_k127_1501331_17	298655.KI912266_gene239	2.068e-48	188.0	COG1280@1|root,COG1280@2|Bacteria	2|Bacteria	E	homoserine transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	LysE
TLS2_k127_1501331_8	526225.Gobs_1743	1.417e-178	563.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria,4ES8V@85013|Frankiales	201174|Actinobacteria	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS2_k127_1501331_18	1123320.KB889707_gene7983	2.331e-11	74.0	2E39G@1|root,32Y91@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1501331_15	1298863.AUEP01000009_gene26	5.028e-98	328.0	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_1501331_5	67315.JOBD01000016_gene6389	1.98e-193	614.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS2_k127_1501331_14	1386089.N865_10010	9.503e-107	356.0	COG1177@1|root,COG1177@2|Bacteria,2GJ6Q@201174|Actinobacteria,4FEZB@85021|Intrasporangiaceae	201174|Actinobacteria	E	COG1177 ABC-type spermidine putrescine transport system, permease component II	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS2_k127_1501331_13	1463820.JOGW01000028_gene2775	7.938e-115	397.0	COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria	201174|Actinobacteria	E	ABC-type spermidine putrescine transport system, permease component I	potB	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS2_k127_1501331_9	1463934.JOCF01000037_gene2037	1.691e-160	523.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
TLS2_k127_1501331_11	1380370.JIBA01000014_gene1861	7.787e-128	422.0	COG0687@1|root,COG0687@2|Bacteria,2GKVG@201174|Actinobacteria,4FEPY@85021|Intrasporangiaceae	201174|Actinobacteria	E	COG0687 Spermidine putrescine-binding periplasmic protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_6,SBP_bac_8
TLS2_k127_1501331_1	1123319.AUBE01000024_gene2190	9.731e-238	744.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_1501331_16	1380354.JIAN01000007_gene161	2.901e-70	241.0	COG1522@1|root,COG1522@2|Bacteria,2GP1P@201174|Actinobacteria	201174|Actinobacteria	K	AsnC family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS2_k127_1501331_0	1380347.JNII01000008_gene4088	6.359e-251	787.0	COG0161@1|root,COG0161@2|Bacteria,2GKF6@201174|Actinobacteria,4ERWH@85013|Frankiales	201174|Actinobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	tpa	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
TLS2_k127_1571983_4	1463864.JOGO01000057_gene3893	1.733e-45	169.0	COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
TLS2_k127_1571983_2	1120949.KB903328_gene8960	7.971e-56	210.0	2DMZ3@1|root,32UHB@2|Bacteria,2IQMH@201174|Actinobacteria,4DFK7@85008|Micromonosporales	201174|Actinobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
TLS2_k127_1571983_3	593907.Celgi_2644	1.135e-46	175.0	28MMU@1|root,2ZAXG@2|Bacteria,2HAD5@201174|Actinobacteria,4F216@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1571983_1	593907.Celgi_1972	7.188e-62	226.0	COG0265@1|root,COG0265@2|Bacteria,2HXVH@201174|Actinobacteria,4F14S@85016|Cellulomonadaceae	201174|Actinobacteria	O	PFAM peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
TLS2_k127_1571983_6	935839.JAGJ01000007_gene3234	3.138e-19	101.0	2EJQU@1|root,33DFN@2|Bacteria,2IHQ3@201174|Actinobacteria,4F4JQ@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1571983_5	1313172.YM304_17310	4.593e-28	118.0	COG3467@1|root,COG3467@2|Bacteria,2IQ9Y@201174|Actinobacteria	201174|Actinobacteria	K	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Pyridox_ox_2
TLS2_k127_1571983_0	1348663.KCH_48490	3.619e-94	331.0	COG0451@1|root,COG0451@2|Bacteria,2GNH5@201174|Actinobacteria,2M4QF@2063|Kitasatospora	201174|Actinobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_1571983_7	979556.MTES_3049	0.0008703	43.0	COG3237@1|root,COG3237@2|Bacteria,2GQQ4@201174|Actinobacteria,4FQH1@85023|Microbacteriaceae	201174|Actinobacteria	S	CsbD-like	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
TLS2_k127_1600756_5	196162.Noca_4346	8.916e-31	126.0	COG2197@1|root,COG2197@2|Bacteria,2GSEU@201174|Actinobacteria,4DTUU@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_1600756_3	136273.GY22_05080	1.653e-170	550.0	COG1070@1|root,COG1070@2|Bacteria,2GNCR@201174|Actinobacteria,1WBDD@1268|Micrococcaceae	201174|Actinobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.12,2.7.1.17	ko:K00851,ko:K00854	ko00030,ko00040,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00040,map01100,map01110,map01120,map01130,map01200	M00014	R01639,R01737	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS2_k127_1600756_2	1146883.BLASA_3025	4.264e-190	614.0	COG2610@1|root,COG2610@2|Bacteria,2GITQ@201174|Actinobacteria	201174|Actinobacteria	EG	Gluconate	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
TLS2_k127_1600756_1	1429046.RR21198_1993	4.404e-210	666.0	COG0477@1|root,COG0477@2|Bacteria,2GITS@201174|Actinobacteria,4FXZ9@85025|Nocardiaceae	201174|Actinobacteria	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_1600756_0	479435.Kfla_3310	7.009e-308	960.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4DTFU@85009|Propionibacteriales	201174|Actinobacteria	G	Fibronectin type III-like domain	bglB	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
TLS2_k127_1600756_4	405948.SACE_6341	5.533e-32	132.0	COG0262@1|root,COG0262@2|Bacteria,2GKX0@201174|Actinobacteria,4E4E5@85010|Pseudonocardiales	201174|Actinobacteria	H	Dihydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_1600756_6	1304865.JAGF01000001_gene3958	1.161e-16	87.0	2DNYD@1|root,32ZSP@2|Bacteria,2HM65@201174|Actinobacteria,4F30Q@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1641362_0	1048339.KB913029_gene3893	1.168e-171	552.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4ES0F@85013|Frankiales	201174|Actinobacteria	L	DNA polymerase LigD	ligD	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
TLS2_k127_1641362_3	1386089.N865_12800	2.731e-57	219.0	COG0229@1|root,COG0229@2|Bacteria,2IHV0@201174|Actinobacteria,4FGN2@85021|Intrasporangiaceae	201174|Actinobacteria	O	Peptide-methionine (R)-S-oxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
TLS2_k127_1641362_2	67373.JOBF01000014_gene4655	4.076e-109	379.0	COG3253@1|root,COG3253@2|Bacteria,2GK24@201174|Actinobacteria	201174|Actinobacteria	S	chlorite dismutase	cld	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
TLS2_k127_1641362_1	1120950.KB892748_gene3252	3.163e-145	475.0	COG1232@1|root,COG1232@2|Bacteria,2GMMA@201174|Actinobacteria,4DNZH@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemG	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS2_k127_1641362_5	1463881.KL591010_gene5341	7.603e-09	59.0	COG3206@1|root,COG3206@2|Bacteria,2GPMH@201174|Actinobacteria	201174|Actinobacteria	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
TLS2_k127_1673604_4	1385519.N801_08965	2.465e-56	214.0	COG0657@1|root,COG0657@2|Bacteria,2GNKU@201174|Actinobacteria,4FHBB@85021|Intrasporangiaceae	201174|Actinobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS2_k127_1673604_2	1449044.JMLE01000011_gene3396	5.151e-119	394.0	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,1W8EZ@1268|Micrococcaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_1673604_3	590998.Celf_3572	5.502e-61	224.0	COG4430@1|root,COG4430@2|Bacteria,2II0D@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
TLS2_k127_1673604_1	1429046.RR21198_1619	1.058e-153	495.0	COG0167@1|root,COG0167@2|Bacteria,2GN1V@201174|Actinobacteria,4G5PN@85025|Nocardiaceae	201174|Actinobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TLS2_k127_1673604_0	1429046.RR21198_1620	0.0	1861.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,2I995@201174|Actinobacteria,4G5GR@85025|Nocardiaceae	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,PFOR_II,POR,POR_N,TPP_enzyme_C
TLS2_k127_1706354_2	926554.KI912633_gene3916	4.441e-99	332.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
TLS2_k127_1706354_5	1348663.KCH_75410	3.453e-51	194.0	COG4226@1|root,COG4226@2|Bacteria,2IKXB@201174|Actinobacteria,2M5EA@2063|Kitasatospora	201174|Actinobacteria	S	protein encoded in hypervariable junctions of pilus gene clusters	-	-	-	-	-	-	-	-	-	-	-	-	HicB
TLS2_k127_1706354_4	47763.JNZA01000009_gene5571	2.064e-73	265.0	COG3595@1|root,COG3595@2|Bacteria,2GJZC@201174|Actinobacteria	201174|Actinobacteria	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_1706354_0	1449976.KALB_1660	2.433e-142	460.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DXJX@85010|Pseudonocardiales	201174|Actinobacteria	V	Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_1706354_1	1121272.KB903291_gene3442	4.986e-101	351.0	COG0842@1|root,COG0842@2|Bacteria,2GIVW@201174|Actinobacteria,4DB65@85008|Micromonosporales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_1706354_3	1122609.AUGT01000005_gene1570	3.336e-90	306.0	COG5006@1|root,COG5006@2|Bacteria,2GJKB@201174|Actinobacteria,4DQ71@85009|Propionibacteriales	201174|Actinobacteria	S	EamA-like transporter family	-	-	-	ko:K11939	-	-	-	-	ko00000,ko02000	2.A.7.3.6	-	-	EamA
TLS2_k127_1706354_6	1077974.GOEFS_120_00340	9.077e-48	176.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_1706354_8	266835.14022762	5.418e-05	46.0	COG0596@1|root,COG0596@2|Bacteria,1RIUT@1224|Proteobacteria,2UBCU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_1707833_1	58123.JOFJ01000001_gene3001	2.796e-213	674.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EG83@85012|Streptosporangiales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
TLS2_k127_1707833_0	471852.Tcur_2882	2.419e-246	781.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EGNQ@85012|Streptosporangiales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K02021,ko:K06147,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_membrane,ABC_tran
TLS2_k127_1707833_2	1304865.JAGF01000001_gene998	1.684e-33	135.0	2EGCD@1|root,33A46@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Septum_form
TLS2_k127_17153_7	981369.JQMJ01000004_gene5030	1.071e-09	61.0	COG0491@1|root,COG0491@2|Bacteria,2GMHY@201174|Actinobacteria,2NFSF@228398|Streptacidiphilus	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_17153_3	298655.KI912266_gene3291	5.153e-35	140.0	COG2197@1|root,COG3629@1|root,COG3899@1|root,COG2197@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,2I3CX@201174|Actinobacteria,4ES0P@85013|Frankiales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,GerE,Trans_reg_C
TLS2_k127_17153_0	1123320.KB889664_gene977	1.702e-110	366.0	COG2141@1|root,COG2141@2|Bacteria,2GKRH@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_17153_1	1048339.KB913029_gene3710	1.423e-81	292.0	2AUNZ@1|root,31KBW@2|Bacteria,2GP4I@201174|Actinobacteria,4ESY9@85013|Frankiales	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF2786
TLS2_k127_17153_2	485913.Krac_5322	6.694e-48	188.0	COG2320@1|root,COG2320@2|Bacteria	2|Bacteria	Q	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	-	-	-	-	-	-	-	-	-	-	-	-	GrpB,Methyltransf_11
TLS2_k127_17153_4	591159.ACEZ01000081_gene6557	9.309e-35	149.0	COG0346@1|root,COG0346@2|Bacteria,2IIMV@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,TetR_N
TLS2_k127_17153_6	153496.JNAB01000013_gene1169	1.554e-14	79.0	2ESJ3@1|root,33K3T@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS2_k127_17153_5	298654.FraEuI1c_6684	3.504e-33	139.0	COG2267@1|root,COG2267@2|Bacteria,2IDKG@201174|Actinobacteria	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_1726962_0	1122609.AUGT01000003_gene2289	5.927e-175	558.0	COG0769@1|root,COG0769@2|Bacteria,2GME3@201174|Actinobacteria,4DPYG@85009|Propionibacteriales	201174|Actinobacteria	M	Mur ligase middle domain	-	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M,TPR_5
TLS2_k127_1726962_1	110319.CF8_2114	1.587e-127	413.0	COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria,4DNM7@85009|Propionibacteriales	201174|Actinobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	inhA	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_1726962_2	861360.AARI_15930	2.26e-108	355.0	COG1028@1|root,COG1028@2|Bacteria,2GK6C@201174|Actinobacteria,1W7EE@1268|Micrococcaceae	201174|Actinobacteria	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_1726962_3	479432.Sros_5942	1.571e-30	123.0	COG3360@1|root,COG3360@2|Bacteria,2IQ6Z@201174|Actinobacteria,4EK7T@85012|Streptosporangiales	201174|Actinobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
TLS2_k127_1726962_4	1304865.JAGF01000001_gene3625	3.776e-18	89.0	2EGIC@1|root,33AAH@2|Bacteria,2IKSC@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3099)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3099
TLS2_k127_1791708_14	298654.FraEuI1c_3135	2.998e-33	134.0	2BAK4@1|root,3240W@2|Bacteria,2H8T3@201174|Actinobacteria	201174|Actinobacteria	S	Putative mono-oxygenase ydhR	-	-	-	-	-	-	-	-	-	-	-	-	ydhR
TLS2_k127_1791708_0	298654.FraEuI1c_3133	3.201e-234	740.0	COG0745@1|root,COG2197@1|root,COG2909@1|root,COG0745@2|Bacteria,COG2197@2|Bacteria,COG2909@2|Bacteria,2I5VD@201174|Actinobacteria,4ET3N@85013|Frankiales	201174|Actinobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1791708_9	1157637.KB892113_gene5037	1.333e-84	289.0	COG2818@1|root,COG2818@2|Bacteria,2IFH0@201174|Actinobacteria	201174|Actinobacteria	L	Glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
TLS2_k127_1791708_13	1137271.AZUM01000010_gene1799	1.768e-39	152.0	COG3427@1|root,COG3427@2|Bacteria,2II8Y@201174|Actinobacteria,4E5GT@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_1791708_15	67257.JODR01000029_gene3054	1.955e-14	81.0	COG3599@1|root,COG3599@2|Bacteria,2IQX3@201174|Actinobacteria	201174|Actinobacteria	D	regulation of cell shape	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1791708_4	44060.JODL01000001_gene3251	1.607e-130	423.0	COG0294@1|root,COG0294@2|Bacteria,2GJNI@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP2	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TLS2_k127_1791708_11	1048339.KB913029_gene22	2.66e-65	238.0	COG1611@1|root,COG1611@2|Bacteria,2GMM1@201174|Actinobacteria,4ESQ6@85013|Frankiales	201174|Actinobacteria	S	Belongs to the LOG family	-	GO:0003674,GO:0003824,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009308,GO:0009690,GO:0009691,GO:0009987,GO:0010817,GO:0016787,GO:0016798,GO:0016799,GO:0034754,GO:0042445,GO:0042446,GO:0044237,GO:0044249,GO:0046483,GO:0065007,GO:0065008,GO:0071704,GO:1901564	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TLS2_k127_1791708_5	1122138.AQUZ01000003_gene538	1.51e-116	381.0	COG1611@1|root,COG1611@2|Bacteria,2GKJH@201174|Actinobacteria,4DPM7@85009|Propionibacteriales	201174|Actinobacteria	S	Belongs to the LOG family	fmt2	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TLS2_k127_1791708_8	1464048.JNZS01000007_gene4436	4.814e-86	295.0	COG0655@1|root,COG0655@2|Bacteria,2GTN2@201174|Actinobacteria,4DI0Y@85008|Micromonosporales	201174|Actinobacteria	S	Flavodoxin-like fold	wrbA	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
TLS2_k127_1791708_2	446466.Cfla_0998	4.042e-145	469.0	COG0624@1|root,COG0624@2|Bacteria,2GK09@201174|Actinobacteria,4F0VW@85016|Cellulomonadaceae	201174|Actinobacteria	E	Peptidase dimerisation domain	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_1791708_3	1048339.KB913029_gene26	8.928e-135	435.0	COG2171@1|root,COG2171@2|Bacteria,2GIZ9@201174|Actinobacteria,4ERUF@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA	dapD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008666,GO:0016020,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0030312,GO:0031402,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0071944	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1201c	Hexapep_2,THDPS_M
TLS2_k127_1791708_7	1157637.KB892111_gene4216	2.244e-106	355.0	COG0667@1|root,COG0667@2|Bacteria,2GJWD@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_1791708_10	1385519.N801_04995	2.319e-81	281.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4FFXH@85021|Intrasporangiaceae	201174|Actinobacteria	EP	Peptide ABC transporter permease	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
TLS2_k127_1791708_12	479432.Sros_8933	2.134e-48	185.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria,4EH4M@85012|Streptosporangiales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
TLS2_k127_1791708_6	1048339.KB913029_gene27	3.017e-108	361.0	COG0739@1|root,COG0791@1|root,COG0739@2|Bacteria,COG0791@2|Bacteria,2GKXN@201174|Actinobacteria,4EXF5@85013|Frankiales	201174|Actinobacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1791708_1	28444.JODQ01000003_gene4755	5.709e-162	515.0	COG0436@1|root,COG0436@2|Bacteria,2GJMI@201174|Actinobacteria,4EGV1@85012|Streptosporangiales	201174|Actinobacteria	E	Aminotransferase class I and II	dapC	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS2_k127_1810009_0	105422.BBPM01000026_gene4062	8.244e-81	285.0	COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria,2NH0G@228398|Streptacidiphilus	201174|Actinobacteria	S	MazG nucleotide pyrophosphohydrolase domain	mazG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0042454,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0047693,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
TLS2_k127_1810009_1	1440053.JOEI01000007_gene2356	7.208e-14	83.0	COG0760@1|root,COG0760@2|Bacteria,2GJDI@201174|Actinobacteria	201174|Actinobacteria	O	SurA N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SurA_N_3
TLS2_k127_1845880_3	1110697.NCAST_12_00060	5.535e-46	171.0	2AY0M@1|root,31Q26@2|Bacteria,2IMBI@201174|Actinobacteria,4G24E@85025|Nocardiaceae	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N,SHOCT
TLS2_k127_1845880_2	1283283.ATXA01000001_gene1277	6.233e-88	310.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,4ES8E@85013|Frankiales	201174|Actinobacteria	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
TLS2_k127_1845880_1	67281.JNZZ01000068_gene4069	5.653e-115	379.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,41A0H@629295|Streptomyces griseus group	201174|Actinobacteria	C	Electron transfer flavoprotein FAD-binding domain	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TLS2_k127_1845880_0	1120949.KB903357_gene4764	0.0	1035.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria,4D9DT@85008|Micromonosporales	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,Nitrate_red_gam
TLS2_k127_1871461_26	330084.JNYZ01000015_gene6011	6.238e-16	77.0	COG0583@1|root,COG0583@2|Bacteria,2GK13@201174|Actinobacteria,4E3IQ@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_1871461_29	196162.Noca_0393	1.315e-07	56.0	2BD8A@1|root,326WI@2|Bacteria,2HCG9@201174|Actinobacteria,4DW5C@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1871461_5	1075090.GOAMR_14_00490	1.712e-196	624.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4GDMM@85026|Gordoniaceae	201174|Actinobacteria	E	Zinc-binding dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_1871461_17	479431.Namu_4769	2.584e-68	234.0	COG4668@1|root,COG4668@2|Bacteria,2IKK6@201174|Actinobacteria,4EW3C@85013|Frankiales	201174|Actinobacteria	H	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	mtlF	-	2.7.1.197,2.7.1.202	ko:K02768,ko:K02798,ko:K11183	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273,M00274	R02704,R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5	-	-	PTS_EIIA_2
TLS2_k127_1871461_3	479431.Namu_0054	3.191e-236	740.0	COG2213@1|root,COG2213@2|Bacteria,2GMYR@201174|Actinobacteria,4ES9E@85013|Frankiales	201174|Actinobacteria	G	TIGRFAM PTS system, mannitol-specific IIC subunit	mtlA	-	2.7.1.197	ko:K02798,ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	M00274	R02704	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
TLS2_k127_1871461_20	1123065.ATWL01000005_gene1255	4.431e-36	140.0	COG2149@1|root,COG2149@2|Bacteria,2GQU9@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
TLS2_k127_1871461_21	67275.JOAP01000020_gene2003	7.963e-36	152.0	COG1277@1|root,COG1277@2|Bacteria,2GSIR@201174|Actinobacteria	201174|Actinobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_1871461_13	1123320.KB889723_gene7540	5.323e-83	288.0	COG1131@1|root,COG1131@2|Bacteria,2IH0X@201174|Actinobacteria	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1871461_27	1160137.KB907307_gene1279	3.191e-13	76.0	2ASXR@1|root,31IDA@2|Bacteria,2GWS7@201174|Actinobacteria,4G579@85025|Nocardiaceae	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
TLS2_k127_1871461_28	441620.Mpop_5334	4.126e-10	68.0	2CCDG@1|root,32RVE@2|Bacteria,1N8P9@1224|Proteobacteria,2UI79@28211|Alphaproteobacteria,1JVA2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1871461_6	1211815.CBYP010000002_gene1993	6.917e-179	571.0	COG2239@1|root,COG2239@2|Bacteria,2GMMK@201174|Actinobacteria	201174|Actinobacteria	P	transporter mgtE	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N,PRC
TLS2_k127_1871461_22	1122622.ATWJ01000013_gene208	6.265e-27	115.0	COG0599@1|root,COG0599@2|Bacteria,2IRPW@201174|Actinobacteria,4FJCM@85021|Intrasporangiaceae	201174|Actinobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_1871461_14	68170.KL590530_gene11500	2.489e-82	285.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4DY2Y@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_1871461_10	1278078.G419_24992	6.234e-126	419.0	COG0628@1|root,COG0628@2|Bacteria,2GM01@201174|Actinobacteria,4FXD0@85025|Nocardiaceae	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_1871461_8	1114959.SZMC14600_22223	5.888e-160	514.0	COG2230@1|root,COG2230@2|Bacteria,2GJ94@201174|Actinobacteria,4DXZT@85010|Pseudonocardiales	201174|Actinobacteria	M	Cyclopropane-fatty-acyl-phospholipid synthase	cfa	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS2_k127_1871461_7	644283.Micau_1054	6.366e-174	565.0	COG0277@1|root,COG0277@2|Bacteria,2GKQR@201174|Actinobacteria,4DAVD@85008|Micromonosporales	201174|Actinobacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
TLS2_k127_1871461_24	1123023.JIAI01000004_gene8314	5.438e-19	91.0	arCOG13021@1|root,33BFU@2|Bacteria,2GTY3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1871461_2	211114.JOEF01000034_gene1436	2.053e-250	796.0	COG1012@1|root,COG1012@2|Bacteria,2GT45@201174|Actinobacteria,4E00S@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS2_k127_1871461_1	1123023.JIAI01000012_gene9190	3.136e-261	827.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2GNII@201174|Actinobacteria,4DYAF@85010|Pseudonocardiales	201174|Actinobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
TLS2_k127_1871461_11	1122138.AQUZ01000012_gene6041	3.382e-104	353.0	2C1EG@1|root,2Z7MZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1871461_23	35754.JNYJ01000001_gene7322	7.229e-20	105.0	2EMIT@1|root,33F7D@2|Bacteria,2GRD4@201174|Actinobacteria,4DFSZ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1871461_0	1123023.JIAI01000016_gene3379	1.518e-291	910.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4DXK7@85010|Pseudonocardiales	201174|Actinobacteria	P	E1-E2 ATPase	copB	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
TLS2_k127_1871461_15	1068978.AMETH_5156	3.085e-81	284.0	COG1752@1|root,COG1752@2|Bacteria,2GNBM@201174|Actinobacteria,4E21F@85010|Pseudonocardiales	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS2_k127_1871461_4	1120950.KB892731_gene3813	3.216e-199	634.0	COG0380@1|root,COG0380@2|Bacteria,2GMX7@201174|Actinobacteria,4DNDY@85009|Propionibacteriales	201174|Actinobacteria	G	Glycosyltransferase family 20	otsA	GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
TLS2_k127_1871461_19	1304865.JAGF01000001_gene606	7.21e-37	141.0	2CUM0@1|root,32SVJ@2|Bacteria,2IQG7@201174|Actinobacteria,4F1EW@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3263)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3263
TLS2_k127_1871461_30	1211815.CBYP010000028_gene1042	1.848e-05	54.0	2DP6P@1|root,330SA@2|Bacteria,2IIAP@201174|Actinobacteria,4ETIY@85013|Frankiales	201174|Actinobacteria	S	LytR cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C
TLS2_k127_1871461_12	1120950.KB892768_gene5364	2.136e-100	334.0	COG1946@1|root,COG1946@2|Bacteria,2GJ1B@201174|Actinobacteria,4DN4N@85009|Propionibacteriales	201174|Actinobacteria	I	Acyl-CoA thioesterase	tesB	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
TLS2_k127_1871461_16	471852.Tcur_0794	1.081e-79	280.0	COG1877@1|root,COG1877@2|Bacteria,2GMKW@201174|Actinobacteria,4EII2@85012|Streptosporangiales	201174|Actinobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
TLS2_k127_1871461_9	298653.Franean1_0178	3.404e-157	509.0	COG0380@1|root,COG0380@2|Bacteria,2GMX7@201174|Actinobacteria,4ESJT@85013|Frankiales	201174|Actinobacteria	G	PFAM Glycosyl transferase, family 20	otsA	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
TLS2_k127_1871461_18	471852.Tcur_2630	6.802e-38	151.0	2CR5C@1|root,32SNF@2|Bacteria,2IT0H@201174|Actinobacteria,4EJMI@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
TLS2_k127_1871461_25	136273.GY22_02535	9.077e-17	83.0	COG0463@1|root,COG0463@2|Bacteria,2I2NK@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	Glycos_transf_2
TLS2_k127_1893472_6	543632.JOJL01000005_gene4841	6.575e-11	68.0	COG1765@1|root,COG1765@2|Bacteria,2IMBV@201174|Actinobacteria,4DKMC@85008|Micromonosporales	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_1893472_1	446469.Sked_24550	3.831e-160	524.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria	201174|Actinobacteria	G	alpha amylase, catalytic	nplT	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459
TLS2_k127_1893472_0	1288083.AUKR01000002_gene4500	5.485e-215	691.0	COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria	201174|Actinobacteria	P	transporter	sdcS	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
TLS2_k127_1893472_2	298655.KI912266_gene2705	7.245e-144	497.0	COG3290@1|root,COG3290@2|Bacteria,2GIRZ@201174|Actinobacteria,4EREH@85013|Frankiales	201174|Actinobacteria	T	PAS domain containing protein	-	-	2.7.13.3	ko:K02476	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,PAS_8,sCache_3_2
TLS2_k127_1893472_5	1121272.KB903249_gene1651	1.044e-77	274.0	COG4565@1|root,COG4565@2|Bacteria,2GMAN@201174|Actinobacteria,4DA1U@85008|Micromonosporales	201174|Actinobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_IclR,Response_reg
TLS2_k127_1893472_3	1184607.AUCHE_16_00760	2.37e-89	310.0	COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria,4F695@85018|Dermatophilaceae	201174|Actinobacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS2_k127_1893472_4	85643.Tmz1t_3053	1.563e-88	300.0	COG1794@1|root,COG1794@2|Bacteria,1MV03@1224|Proteobacteria,2VHS8@28216|Betaproteobacteria,2KXI9@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the aspartate glutamate racemases family	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
TLS2_k127_1919388_2	1894.JOER01000108_gene3126	1.089e-162	526.0	COG1488@1|root,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C
TLS2_k127_1919388_1	1380393.JHVP01000006_gene3947	2.492e-217	697.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4ERKW@85013|Frankiales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_1919388_3	73044.JNXP01000012_gene3818	1.042e-111	389.0	COG1414@1|root,COG1414@2|Bacteria,2GKB0@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	ltbR	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS2_k127_1919388_0	1120950.KB892741_gene2691	1.85e-243	793.0	COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria,4DNZM@85009|Propionibacteriales	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TLS2_k127_1919388_4	351607.Acel_1590	4.042e-87	294.0	COG0066@1|root,COG0066@2|Bacteria,2GJ8Z@201174|Actinobacteria,4ERFW@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
TLS2_k127_1919388_5	110319.CF8_2896	3.238e-39	156.0	COG0776@1|root,COG0776@2|Bacteria,2GV0M@201174|Actinobacteria,4DR53@85009|Propionibacteriales	201174|Actinobacteria	L	Belongs to the bacterial histone-like protein family	hup	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006355,GO:0006725,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010106,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019725,GO:0030003,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0040007,GO:0042262,GO:0042592,GO:0042594,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046916,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0060255,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090143,GO:0090304,GO:0097100,GO:0097159,GO:0098771,GO:0140110,GO:1901360,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS2_k127_1920478_2	219305.MCAG_02820	3.536e-154	518.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4DA6Q@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
TLS2_k127_1920478_6	1120950.KB892707_gene4686	1.185e-49	186.0	COG3346@1|root,COG3346@2|Bacteria,2GR90@201174|Actinobacteria,4DR52@85009|Propionibacteriales	201174|Actinobacteria	S	SURF1 family	-	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	SURF1
TLS2_k127_1920478_0	457429.ABJI02000647_gene4205	4.123e-257	804.0	COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria	201174|Actinobacteria	G	Glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
TLS2_k127_1920478_5	1394178.AWOO02000020_gene7522	1.945e-75	270.0	COG1619@1|root,COG1619@2|Bacteria,2HPR8@201174|Actinobacteria,4EIB1@85012|Streptosporangiales	201174|Actinobacteria	V	LD-carboxypeptidase	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
TLS2_k127_1920478_3	935866.JAER01000002_gene1859	4.254e-98	326.0	COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria,4DNZG@85009|Propionibacteriales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_1920478_1	479435.Kfla_3305	2.166e-255	803.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4DN7W@85009|Propionibacteriales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_1920478_4	1449353.JQMQ01000005_gene1499	7.495e-86	295.0	COG1024@1|root,COG1024@2|Bacteria,2GKC4@201174|Actinobacteria,2NFFV@228398|Streptacidiphilus	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	echA	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_1920478_8	67275.JOAP01000055_gene3125	3.515e-24	107.0	2E4I7@1|root,32ZDA@2|Bacteria,2IQBB@201174|Actinobacteria	201174|Actinobacteria	S	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1920478_7	590998.Celf_3361	9.347e-29	121.0	COG3764@1|root,COG3764@2|Bacteria,2IR30@201174|Actinobacteria,4F2MS@85016|Cellulomonadaceae	201174|Actinobacteria	M	PFAM peptidase C60 sortase A and B	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
TLS2_k127_1922940_2	1122138.AQUZ01000014_gene6999	0.0001061	54.0	COG0791@1|root,COG0791@2|Bacteria,2GKHE@201174|Actinobacteria,4DQS1@85009|Propionibacteriales	201174|Actinobacteria	M	NlpC/P60 family	-	-	-	ko:K21471,ko:K21473	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
TLS2_k127_1922940_0	290397.Adeh_2255	8.107e-111	391.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,437TD@68525|delta/epsilon subdivisions,2WT6I@28221|Deltaproteobacteria,2YX1E@29|Myxococcales	28221|Deltaproteobacteria	C	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS2_k127_1922940_1	222534.KB893750_gene4365	1.322e-85	301.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_1940107_3	882083.SacmaDRAFT_1254	1.884e-05	48.0	COG0454@1|root,COG0456@2|Bacteria,2IQC7@201174|Actinobacteria,4E3GV@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_1940107_0	1123319.AUBE01000004_gene601	7.404e-127	413.0	COG4977@1|root,COG4977@2|Bacteria,2GIRA@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
TLS2_k127_1940107_1	222534.KB893672_gene3062	6.66e-69	245.0	COG1295@1|root,COG1295@2|Bacteria,2ICUY@201174|Actinobacteria,4EVFQ@85013|Frankiales	201174|Actinobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_1940107_2	543632.JOJL01000004_gene4136	9.122e-42	158.0	COG1765@1|root,COG1765@2|Bacteria,2IRWN@201174|Actinobacteria,4DE5H@85008|Micromonosporales	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS2_k127_1940784_1	1122609.AUGT01000003_gene2289	1.119e-203	646.0	COG0769@1|root,COG0769@2|Bacteria,2GME3@201174|Actinobacteria,4DPYG@85009|Propionibacteriales	201174|Actinobacteria	M	Mur ligase middle domain	-	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M,TPR_5
TLS2_k127_1940784_0	1122609.AUGT01000003_gene2286	0.0	1443.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,2GN0U@201174|Actinobacteria,4DP39@85009|Propionibacteriales	201174|Actinobacteria	HJM	RimK-like ATP-grasp domain	cphA	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Dala_Dala_lig_C,Mur_ligase_C,Mur_ligase_M,RimK
TLS2_k127_1940784_2	1032480.MLP_14770	1.697e-113	376.0	COG4242@1|root,COG4242@2|Bacteria,2I93U@201174|Actinobacteria,4DP1Z@85009|Propionibacteriales	201174|Actinobacteria	PQ	Peptidase family S51	cphB	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
TLS2_k127_1940784_3	298653.Franean1_6925	5.006e-11	73.0	COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria,4ET3J@85013|Frankiales	201174|Actinobacteria	L	HNH endonuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_1948002_4	1120950.KB892707_gene4973	1.063e-47	173.0	COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,4DNI1@85009|Propionibacteriales	201174|Actinobacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3858c	Fer4_20,Pyr_redox_2
TLS2_k127_1948002_1	269800.Tfu_1174	1.438e-190	606.0	COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,4EFPS@85012|Streptosporangiales	201174|Actinobacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3858c	Fer4_20,Pyr_redox_2
TLS2_k127_1948002_3	1134445.AJJM01000013_gene471	2.616e-76	260.0	COG0693@1|root,COG0693@2|Bacteria,2GMMW@201174|Actinobacteria	201174|Actinobacteria	V	Intracellular protease	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
TLS2_k127_1948002_0	367299.JOEE01000005_gene3518	2.258e-209	660.0	COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria,4FEJM@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the formation of phosphoenolpyruvate from pyruvate	pyk	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
TLS2_k127_1948002_2	196162.Noca_3018	1.34e-84	284.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,4DNSI@85009|Propionibacteriales	201174|Actinobacteria	T	ANTAR	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
TLS2_k127_1950528_4	1121017.AUFG01000001_gene2884	2.508e-22	97.0	COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,4FFC2@85021|Intrasporangiaceae	201174|Actinobacteria	GK	Catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_1950528_1	448385.sce5245	3.406e-126	414.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria,2YXAS@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the LDH MDH superfamily. LDH family	ldh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
TLS2_k127_1950528_2	1120959.ATXF01000011_gene230	1.519e-45	169.0	COG0346@1|root,COG0346@2|Bacteria,2IMDZ@201174|Actinobacteria,4FQ8Z@85023|Microbacteriaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_1950528_6	1268303.RHODMAR_2721	1.355e-05	48.0	2AR1Y@1|root,31GAW@2|Bacteria,2HK0E@201174|Actinobacteria,4G7PU@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1950528_0	590998.Celf_3574	6.807e-165	531.0	COG0557@1|root,COG0557@2|Bacteria,2GNSM@201174|Actinobacteria	201174|Actinobacteria	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
TLS2_k127_1950528_3	1121946.AUAX01000015_gene6053	1.819e-24	106.0	COG3371@1|root,COG3371@2|Bacteria,2II34@201174|Actinobacteria,4DDK4@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
TLS2_k127_1959276_7	685727.REQ_22780	8.071e-67	231.0	COG3268@1|root,COG3268@2|Bacteria,2GNGH@201174|Actinobacteria,4FXUS@85025|Nocardiaceae	201174|Actinobacteria	S	Saccharopine dehydrogenase NADP binding domain	LYS1	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
TLS2_k127_1959276_3	1122599.AUGR01000005_gene1973	8.449e-107	368.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,1RQ8G@1236|Gammaproteobacteria,1XK8Z@135619|Oceanospirillales	135619|Oceanospirillales	E	Glutamate decarboxylase and related PLP-dependent	-	-	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
TLS2_k127_1959276_0	1077972.ARGLB_073_01310	7.859e-284	902.0	COG0318@1|root,COG0318@2|Bacteria,2HIY1@201174|Actinobacteria	201174|Actinobacteria	IQ	AMP-dependent synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,PP-binding
TLS2_k127_1959276_11	1172179.AUKV01000052_gene6795	3.356e-49	187.0	COG4188@1|root,COG4188@2|Bacteria,2I6N2@201174|Actinobacteria	201174|Actinobacteria	S	Chlorophyllase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Chlorophyllase2
TLS2_k127_1959276_15	479433.Caci_8846	1.59e-17	92.0	2EV1Z@1|root,33NH1@2|Bacteria,2GZIA@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1959276_13	1137269.AZWL01000005_gene2350	5.835e-37	142.0	COG1950@1|root,COG1950@2|Bacteria,2IHP5@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
TLS2_k127_1959276_8	1464048.JNZS01000019_gene2358	9.155e-66	236.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4DD1H@85008|Micromonosporales	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_1959276_1	649831.L083_4734	2.828e-129	438.0	COG3850@1|root,COG3850@2|Bacteria,2GIWI@201174|Actinobacteria,4D91E@85008|Micromonosporales	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HATPase_c_2,HisKA_3
TLS2_k127_1959276_4	1869.MB27_03195	3.639e-99	327.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,4DB3Q@85008|Micromonosporales	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_1959276_6	1122611.KB903985_gene3664	4.201e-70	251.0	COG0778@1|root,COG0778@2|Bacteria,2I8P3@201174|Actinobacteria,4EN3D@85012|Streptosporangiales	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS2_k127_1959276_12	585531.HMPREF0063_12739	7.182e-42	173.0	COG0394@1|root,COG0394@2|Bacteria,2IM0Q@201174|Actinobacteria,4DR9C@85009|Propionibacteriales	201174|Actinobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	ptpA	GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0035335,GO:0035821,GO:0036211,GO:0042578,GO:0043170,GO:0043207,GO:0043412,GO:0044003,GO:0044046,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052046,GO:0052047,GO:0052048,GO:0052083,GO:0052155,GO:0052173,GO:0052200,GO:0052212,GO:0052255,GO:0052278,GO:0052294,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:0140096,GO:1901564	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS2_k127_1959276_5	1048339.KB913029_gene1591	5.994e-84	295.0	COG3001@1|root,COG3001@2|Bacteria,2GW7W@201174|Actinobacteria,4ET0D@85013|Frankiales	201174|Actinobacteria	G	Fructosamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
TLS2_k127_1959276_10	1123251.ATWM01000001_gene817	6.504e-50	184.0	COG3409@1|root,COG3409@2|Bacteria,2IM37@201174|Actinobacteria,4FHJ0@85021|Intrasporangiaceae	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1959276_2	1120950.KB892751_gene6769	5.098e-121	398.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4DPR9@85009|Propionibacteriales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1959276_9	1120950.KB892751_gene6770	9.789e-63	226.0	COG1277@1|root,COG1277@2|Bacteria,2HGDY@201174|Actinobacteria,4DWE0@85009|Propionibacteriales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1959276_14	110319.CF8_0399	5.543e-21	93.0	2DC18@1|root,2ZCCT@2|Bacteria,2IBBW@201174|Actinobacteria,4DQ74@85009|Propionibacteriales	201174|Actinobacteria	S	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
TLS2_k127_1961976_6	593907.Celgi_0795	1.469e-20	96.0	COG0244@1|root,COG0244@2|Bacteria,2GM0V@201174|Actinobacteria,4F0Q3@85016|Cellulomonadaceae	201174|Actinobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
TLS2_k127_1961976_1	1144275.COCOR_04573	1.251e-126	434.0	COG4425@1|root,COG4425@2|Bacteria,1MXSU@1224|Proteobacteria	1224|Proteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_9,Abhydrolase_9_N
TLS2_k127_1961976_2	58123.JOFJ01000016_gene4000	5.431e-117	381.0	COG0081@1|root,COG0081@2|Bacteria,2GM51@201174|Actinobacteria,4EG6U@85012|Streptosporangiales	201174|Actinobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
TLS2_k127_1961976_4	1343740.M271_21710	1.371e-78	264.0	COG0080@1|root,COG0080@2|Bacteria,2IFCK@201174|Actinobacteria	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
TLS2_k127_1961976_3	1120950.KB892746_gene3584	9.037e-97	324.0	COG0250@1|root,COG0250@2|Bacteria,2GJFW@201174|Actinobacteria,4DPR5@85009|Propionibacteriales	201174|Actinobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusG
TLS2_k127_1961976_7	1120950.KB892746_gene3583	2.405e-19	92.0	COG0690@1|root,COG0690@2|Bacteria,2GQFP@201174|Actinobacteria,4DSA3@85009|Propionibacteriales	201174|Actinobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
TLS2_k127_1961976_0	1463854.JOHT01000007_gene3186	2.289e-209	664.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase	aspC	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_1961976_5	469383.Cwoe_4166	7.941e-35	139.0	COG0673@1|root,COG0673@2|Bacteria,2GN2Z@201174|Actinobacteria,4CRFM@84995|Rubrobacteria	84995|Rubrobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_1962881_0	1120950.KB892768_gene5322	1.994e-168	539.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4DPNM@85009|Propionibacteriales	201174|Actinobacteria	L	DNA Topoisomerase IV	gyrA2	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS2_k127_1962881_3	1380347.JNII01000009_gene2111	7.72e-43	173.0	2DQVM@1|root,338Y0@2|Bacteria,2ISKA@201174|Actinobacteria	201174|Actinobacteria	S	LppX_LprAFG lipoprotein	-	-	-	ko:K14954	ko05152,map05152	-	-	-	ko00000,ko00001	-	-	-	LppX_LprAFG
TLS2_k127_1962881_1	397278.JOJN01000014_gene3580	1.974e-160	526.0	COG0477@1|root,COG2814@2|Bacteria,2I2DZ@201174|Actinobacteria,4DPCP@85009|Propionibacteriales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_1962881_2	397278.JOJN01000014_gene3581	4.23e-54	194.0	COG0288@1|root,COG0288@2|Bacteria,2GM1M@201174|Actinobacteria,4DQAC@85009|Propionibacteriales	201174|Actinobacteria	P	Reversible hydration of carbon dioxide	cah	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS2_k127_1986433_0	1386089.N865_01835	3.371e-77	260.0	COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_1986433_1	1125971.ASJB01000083_gene1735	4.326e-46	169.0	COG1309@1|root,COG1309@2|Bacteria,2IMN5@201174|Actinobacteria,4E40M@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TLS2_k127_1988069_0	1120950.KB892768_gene5273	7.878e-221	694.0	COG4799@1|root,COG4799@2|Bacteria,2I16G@201174|Actinobacteria,4DNAY@85009|Propionibacteriales	201174|Actinobacteria	I	Malonate decarboxylase gamma subunit (MdcE)	accD6	GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009317,GO:0009987,GO:0016042,GO:0016053,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019367,GO:0019752,GO:0030312,GO:0030497,GO:0032787,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:0072330,GO:1901575,GO:1901576,GO:1902494	2.1.3.15,6.4.1.2,6.4.1.3	ko:K18472	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04386	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_1988069_2	1306406.ASHX01000001_gene2935	9.477e-173	550.0	COG0304@1|root,COG0304@2|Bacteria,2GIY4@201174|Actinobacteria	201174|Actinobacteria	IQ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS2_k127_1988069_8	479435.Kfla_2566	3.97e-34	138.0	COG0236@1|root,COG0236@2|Bacteria,2IQ43@201174|Actinobacteria,4DRYW@85009|Propionibacteriales	201174|Actinobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006643,GO:0006644,GO:0006664,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009245,GO:0009247,GO:0009259,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0019637,GO:0019693,GO:0019752,GO:0019842,GO:0030312,GO:0031177,GO:0032787,GO:0033218,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046483,GO:0046493,GO:0048037,GO:0051186,GO:0051192,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072341,GO:0072521,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901360,GO:1901564,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS2_k127_1988069_4	479435.Kfla_2567	3.246e-141	456.0	COG0332@1|root,COG0332@2|Bacteria,2GJP8@201174|Actinobacteria,4DP78@85009|Propionibacteriales	201174|Actinobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
TLS2_k127_1988069_1	1120950.KB892768_gene5269	8.519e-180	571.0	COG0331@1|root,COG0511@1|root,COG0331@2|Bacteria,COG0511@2|Bacteria,2GME0@201174|Actinobacteria,4DPZC@85009|Propionibacteriales	201174|Actinobacteria	I	Acyl transferase domain	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005835,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
TLS2_k127_1988069_5	1120950.KB892768_gene5268	1.214e-133	437.0	COG3835@1|root,COG3835@2|Bacteria,2I2QR@201174|Actinobacteria,4DWX2@85009|Propionibacteriales	201174|Actinobacteria	KT	PucR C-terminal helix-turn-helix domain	-	GO:0008150,GO:0040007	-	-	-	-	-	-	-	-	-	-	HTH_30
TLS2_k127_1988069_3	1120950.KB892768_gene5266	8.715e-154	492.0	COG1387@1|root,COG1387@2|Bacteria,2GMFH@201174|Actinobacteria,4DN4U@85009|Propionibacteriales	201174|Actinobacteria	L	Helix-hairpin-helix domain	polX	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_8,PHP
TLS2_k127_1988069_7	1122182.KB903825_gene500	1.825e-47	176.0	COG1670@1|root,COG1670@2|Bacteria,2IKZC@201174|Actinobacteria,4DEC8@85008|Micromonosporales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS2_k127_1988069_9	1123319.AUBE01000011_gene4536	4.257e-34	148.0	COG4106@1|root,COG4106@2|Bacteria,2I3M6@201174|Actinobacteria	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_1988069_6	1299327.I546_1353	6.985e-57	214.0	COG1741@1|root,COG1741@2|Bacteria,2GJV3@201174|Actinobacteria,23325@1762|Mycobacteriaceae	201174|Actinobacteria	S	Belongs to the pirin family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
TLS2_k127_1988069_11	1206743.BAGM01000076_gene4026	1.15e-06	55.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4FWGU@85025|Nocardiaceae	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_1988069_10	105425.BBPL01000003_gene6823	4.988e-08	54.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,2NGIJ@228398|Streptacidiphilus	201174|Actinobacteria	S	Polyphosphate kinase 2 (PPK2)	ppk2	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006183,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030808,GO:0031323,GO:0031326,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046777,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051704,GO:0055086,GO:0062012,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0080090,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
TLS2_k127_1992562_8	1463841.JOIR01000011_gene2805	7.634e-25	107.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_1992562_6	351607.Acel_1597	2.565e-93	329.0	COG2208@1|root,COG2208@2|Bacteria,2GNS3@201174|Actinobacteria,4EVMK@85013|Frankiales	201174|Actinobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
TLS2_k127_1992562_5	2002.JOEQ01000005_gene3410	1.167e-94	317.0	COG0266@1|root,COG0266@2|Bacteria,2GKUI@201174|Actinobacteria,4EGNF@85012|Streptosporangiales	201174|Actinobacteria	L	Formamidopyrimidine-DNA glycosylase H2TH domain	nei1	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0003906,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034599,GO:0034641,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0090304,GO:0097159,GO:0097506,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K05522,ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_1992562_7	1463920.JOGB01000026_gene6153	5.17e-68	235.0	COG0698@1|root,COG0698@2|Bacteria,2GKJG@201174|Actinobacteria	201174|Actinobacteria	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
TLS2_k127_1992562_0	1120950.KB892765_gene5656	0.0	1080.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4DNEA@85009|Propionibacteriales	201174|Actinobacteria	E	ERAP1-like C-terminal domain	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
TLS2_k127_1992562_1	1265310.CCBD010000064_gene1034	5.679e-289	903.0	COG1640@1|root,COG1640@2|Bacteria,2GM5Z@201174|Actinobacteria,232KW@1762|Mycobacteriaceae	201174|Actinobacteria	G	4-alpha-glucanotransferase	malQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
TLS2_k127_1992562_4	471853.Bcav_3669	5.632e-155	506.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the amidase family	amiB	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS2_k127_1992562_2	1032480.MLP_00570	2.779e-198	666.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,4DWFW@85009|Propionibacteriales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_1992562_3	1048339.KB913029_gene4943	8.152e-165	528.0	COG1505@1|root,COG1505@2|Bacteria,2IRXB@201174|Actinobacteria,4ERQG@85013|Frankiales	201174|Actinobacteria	E	peptidase S9A, prolyl oligopeptidase domain protein beta-propeller	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_201414_7	1089544.KB912942_gene839	3.131e-25	112.0	COG0703@1|root,COG0703@2|Bacteria,2GRFW@201174|Actinobacteria,4E489@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
TLS2_k127_201414_2	1120950.KB892708_gene4302	7.985e-191	608.0	COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4DPU4@85009|Propionibacteriales	201174|Actinobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2540c	Chorismate_synt
TLS2_k127_201414_5	1120950.KB892708_gene4301	2.389e-49	184.0	COG1989@1|root,COG1989@2|Bacteria,2GJ7K@201174|Actinobacteria,4DRTI@85009|Propionibacteriales	201174|Actinobacteria	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
TLS2_k127_201414_3	1123320.KB889665_gene1411	2.43e-80	293.0	COG0169@1|root,COG0169@2|Bacteria,2GPQQ@201174|Actinobacteria	201174|Actinobacteria	E	Shikimate dehydrogenase	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2552c	Shikimate_DH,Shikimate_dh_N
TLS2_k127_201414_4	110319.CF8_1908	4.533e-77	285.0	COG1559@1|root,COG1559@2|Bacteria,2GKGQ@201174|Actinobacteria,4DN3K@85009|Propionibacteriales	201174|Actinobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
TLS2_k127_201414_6	479432.Sros_6093	3.175e-40	171.0	COG0816@1|root,COG0816@2|Bacteria,2IQB0@201174|Actinobacteria,4EJ6B@85012|Streptosporangiales	201174|Actinobacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	ruvX	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
TLS2_k127_201414_0	1122622.ATWJ01000010_gene1429	0.0	1183.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4FE6Z@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS2_k127_201414_9	44060.JODL01000006_gene1477	1.531e-11	74.0	2EGGE@1|root,33A8E@2|Bacteria,2IKUG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_201414_8	1380347.JNII01000008_gene4077	3.938e-24	106.0	COG4768@1|root,COG4768@2|Bacteria,2II1J@201174|Actinobacteria,4ET7N@85013|Frankiales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF948)	-	-	-	-	-	-	-	-	-	-	-	-	DUF948
TLS2_k127_201414_1	1122609.AUGT01000002_gene3971	2.045e-194	618.0	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4DP5Q@85009|Propionibacteriales	201174|Actinobacteria	L	MgsA AAA+ ATPase C terminal	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
TLS2_k127_2017436_0	1304865.JAGF01000001_gene118	4.504e-158	506.0	COG3459@1|root,COG3459@2|Bacteria,2IA66@201174|Actinobacteria	201174|Actinobacteria	G	Putative glucoamylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3131,Glycoamylase
TLS2_k127_2017436_3	471853.Bcav_3574	2.707e-123	404.0	COG0395@1|root,COG0395@2|Bacteria,2GMTH@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter (Permease)	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_2017436_2	1095767.CAHD01000027_gene1648	2.533e-126	413.0	COG1175@1|root,COG1175@2|Bacteria,2GKBJ@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_2017436_1	1095767.CAHD01000027_gene1647	2.816e-152	494.0	COG2182@1|root,COG2182@2|Bacteria,2I2J8@201174|Actinobacteria	201174|Actinobacteria	G	Extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_2017436_4	1095767.CAHD01000027_gene1646	1.292e-113	376.0	COG1609@1|root,COG1609@2|Bacteria,2GJV7@201174|Actinobacteria	201174|Actinobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_2017436_5	106370.Francci3_3895	8.789e-66	228.0	COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,4ESDQ@85013|Frankiales	201174|Actinobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS2_k127_2026341_10	1194165.CAJF01000039_gene1713	9.226e-08	61.0	COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria,4FNJ1@85023|Microbacteriaceae	201174|Actinobacteria	V	HNH nucleases	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222
TLS2_k127_2026341_2	644283.Micau_5077	4.976e-220	691.0	COG0160@1|root,COG0160@2|Bacteria,2I2F3@201174|Actinobacteria,4DAIM@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
TLS2_k127_2026341_4	1307761.L21SP2_0748	4.367e-156	518.0	COG2939@1|root,COG2939@2|Bacteria	2|Bacteria	E	PFAM Peptidase S10, serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
TLS2_k127_2026341_3	1048339.KB913029_gene1446	6.471e-183	582.0	COG0151@1|root,COG0151@2|Bacteria,2I2F5@201174|Actinobacteria,4ERHW@85013|Frankiales	201174|Actinobacteria	F	Belongs to the GARS family	purD	GO:0008150,GO:0040007	6.3.3.1,6.3.4.13	ko:K01945,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
TLS2_k127_2026341_6	675635.Psed_3137	2.427e-124	421.0	COG2141@1|root,COG2141@2|Bacteria,2GPA5@201174|Actinobacteria,4E2HG@85010|Pseudonocardiales	201174|Actinobacteria	C	F420-dependent oxidoreductase, MSMEG_2906 family	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_2026341_1	1120950.KB892790_gene2128	2.835e-234	732.0	COG0015@1|root,COG0015@2|Bacteria,2GKBR@201174|Actinobacteria,4DNYZ@85009|Propionibacteriales	201174|Actinobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
TLS2_k127_2026341_0	653045.Strvi_1813	2.676e-261	819.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the DEAD box helicase family	deaD	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
TLS2_k127_2026341_5	1323361.JPOC01000066_gene163	6.322e-125	415.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4FVUB@85025|Nocardiaceae	201174|Actinobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS2_k127_2026341_9	452863.Achl_1028	8.235e-24	107.0	COG0346@1|root,COG0346@2|Bacteria,2IRQX@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_2026341_7	1150864.MILUP08_46491	2.205e-81	280.0	COG1309@1|root,COG1309@2|Bacteria,2ICWK@201174|Actinobacteria,4DE6I@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_2026341_8	290399.Arth_0613	6.959e-34	133.0	COG2085@1|root,COG2085@2|Bacteria,2GMN3@201174|Actinobacteria	201174|Actinobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
TLS2_k127_2033033_2	479431.Namu_5236	1.043e-44	167.0	2D19V@1|root,32TA6@2|Bacteria,2IRPX@201174|Actinobacteria,4ETBE@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2033033_0	1386089.N865_15125	1.063e-89	313.0	28MY8@1|root,2ZB54@2|Bacteria,2GMYY@201174|Actinobacteria,4FH53@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2033033_1	1298880.AUEV01000002_gene1551	1.835e-72	261.0	COG0477@1|root,COG0477@2|Bacteria,2GIYR@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	ko:K03762	-	-	-	-	ko00000,ko02000	2.A.1.6.4	-	-	MFS_1,Sugar_tr
TLS2_k127_2033033_3	1120959.ATXF01000007_gene2170	2.738e-06	50.0	2DXS3@1|root,3468X@2|Bacteria,2GV4K@201174|Actinobacteria,4FQEH@85023|Microbacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2041292_2	1123023.JIAI01000020_gene2161	1.128e-12	70.0	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria,4DYNG@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
TLS2_k127_2041292_0	1095767.CAHD01000027_gene1651	2.384e-229	728.0	COG3664@1|root,COG3664@2|Bacteria,2GNYC@201174|Actinobacteria	201174|Actinobacteria	G	PFAM glycoside hydrolase family 39	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	F5_F8_type_C,Glyco_hydro_39
TLS2_k127_2041292_1	926564.KI911615_gene4433	1.733e-19	89.0	COG3459@1|root,COG3459@2|Bacteria,2IA66@201174|Actinobacteria	201174|Actinobacteria	G	Putative glucoamylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3131,Glycoamylase
TLS2_k127_20494_2	1385519.N801_10375	2.177e-21	101.0	2ED0J@1|root,336XJ@2|Bacteria,2I7ZH@201174|Actinobacteria,4FGMA@85021|Intrasporangiaceae	201174|Actinobacteria	S	LytR cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C
TLS2_k127_20494_1	1111131.HMPREF1255_0558	1.104e-44	163.0	COG5450@1|root,32SQA@2|Bacteria,2IKJX@201174|Actinobacteria,4DRV1@85009|Propionibacteriales	201174|Actinobacteria	K	Transcription regulator of the Arc MetJ class	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_20494_0	1385518.N798_02040	2.854e-214	680.0	COG0433@1|root,COG0433@2|Bacteria,2GM12@201174|Actinobacteria,4FERS@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
TLS2_k127_2055128_5	710111.FraQA3DRAFT_1855	9.889e-34	130.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria,4ETAA@85013|Frankiales	201174|Actinobacteria	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_2055128_4	1283283.ATXA01000001_gene544	3.325e-36	142.0	COG1714@1|root,COG1714@2|Bacteria,2IN6K@201174|Actinobacteria,4ETDQ@85013|Frankiales	201174|Actinobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS2_k127_2055128_3	1429046.RR21198_5068	1.567e-39	160.0	2EEE7@1|root,33888@2|Bacteria,2IMP5@201174|Actinobacteria,4G0SV@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2055128_2	479431.Namu_1999	1.556e-78	275.0	COG1073@1|root,COG1073@2|Bacteria,2IPVI@201174|Actinobacteria	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2055128_1	1385519.N801_14745	1.366e-163	532.0	2DBMB@1|root,2Z9Y8@2|Bacteria,2I4DG@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
TLS2_k127_2055128_0	1304865.JAGF01000001_gene82	2.87e-185	581.0	COG1064@1|root,COG1064@2|Bacteria,2GKNW@201174|Actinobacteria	201174|Actinobacteria	P	alcohol dehydrogenase	-	-	-	ko:K18382	ko00640,map00640	-	R10703	RC00545	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_2060086_0	471853.Bcav_1730	0.0	1428.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
TLS2_k127_2060086_1	235985.BBPN01000007_gene3271	2.093e-97	334.0	COG1307@1|root,COG1307@2|Bacteria,2GIUV@201174|Actinobacteria,2NFGN@228398|Streptacidiphilus	201174|Actinobacteria	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
TLS2_k127_2060086_2	110319.CF8_1549	3.428e-20	102.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4DRFZ@85009|Propionibacteriales	201174|Actinobacteria	L	Helix-hairpin-helix motif	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
TLS2_k127_2071475_2	42256.RradSPS_2383	8.332e-06	52.0	2CZII@1|root,32T6G@2|Bacteria,2IK4W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2071475_1	1312954.KI914856_gene1175	5.866e-108	359.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria,1W8TK@1268|Micrococcaceae	201174|Actinobacteria	GM	epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_2071475_0	1380354.JIAN01000011_gene3256	1.039e-186	595.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase LigD polymerase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS2_k127_2109750_2	1206101.AZXC01000016_gene3587	1.06e-117	385.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	sigF	GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_2109750_5	1463881.KL591015_gene607	1.078e-08	63.0	2DTKM@1|root,33KSC@2|Bacteria,2IHXR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2109750_4	1048339.KB913029_gene3300	1.69e-45	164.0	2DMIE@1|root,32RSG@2|Bacteria,2IQCG@201174|Actinobacteria,4ET35@85013|Frankiales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB	GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS2_k127_2109750_1	253839.SSNG_04783	8.561e-187	598.0	COG3920@1|root,COG3920@2|Bacteria,2GKMP@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	pdtaS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,H_kinase_N,HisKA_2,PAS_4
TLS2_k127_2109750_3	1120950.KB892749_gene3309	1.131e-86	297.0	2DM3D@1|root,31J5I@2|Bacteria,2I578@201174|Actinobacteria,4DWXX@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF2785)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2785
TLS2_k127_2109750_0	1120950.KB892749_gene3313	6.219e-254	793.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4DPFV@85009|Propionibacteriales	201174|Actinobacteria	EH	TPP binding domain protein	ilvG	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1820	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_2118172_2	1043493.BBLU01000005_gene1958	1.009e-74	255.0	COG2987@1|root,COG2987@2|Bacteria,2GP10@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
TLS2_k127_2118172_1	1449355.JQNR01000005_gene2488	1.514e-238	762.0	COG2986@1|root,COG2986@2|Bacteria,2GJZW@201174|Actinobacteria	201174|Actinobacteria	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
TLS2_k127_2118172_3	1123023.JIAI01000002_gene4960	1.806e-69	265.0	COG1414@1|root,COG1414@2|Bacteria,2GM23@201174|Actinobacteria,4E01E@85010|Pseudonocardiales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS2_k127_2118172_0	1120950.KB892782_gene286	6.322e-318	989.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria,4DNU0@85009|Propionibacteriales	201174|Actinobacteria	C	Cysteine-rich domain	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
TLS2_k127_2122236_0	1380393.JHVP01000005_gene3587	2e-176	557.0	COG0151@1|root,COG0151@2|Bacteria,2I624@201174|Actinobacteria,4EXFF@85013|Frankiales	201174|Actinobacteria	F	Carbamoyl-phosphate synthase L chain, ATP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2122236_1	1380393.JHVP01000005_gene3586	1.597e-77	275.0	COG3340@1|root,COG3340@2|Bacteria,2IGG2@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the peptidase S51 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
TLS2_k127_2122236_2	1193181.BN10_470025	2.64e-43	175.0	COG2382@1|root,COG2382@2|Bacteria,2I844@201174|Actinobacteria,4FE3S@85021|Intrasporangiaceae	201174|Actinobacteria	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	DUF3327,Esterase
TLS2_k127_2126477_2	1123023.JIAI01000005_gene822	5.92e-88	304.0	COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,4E0WG@85010|Pseudonocardiales	201174|Actinobacteria	GK	Transcriptional regulator sugar kinase	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_2126477_0	561175.KB894094_gene1507	2.486e-138	444.0	COG0024@1|root,COG0024@2|Bacteria,2GKIZ@201174|Actinobacteria,4EFWI@85012|Streptosporangiales	201174|Actinobacteria	J	Metallopeptidase family M24	map	GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS2_k127_2126477_3	1064537.AGSO01000010_gene2514	5.121e-09	62.0	2EHMB@1|root,33BD3@2|Bacteria,2HHKR@201174|Actinobacteria,4FDAH@85020|Dermabacteraceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2126477_4	1385520.N802_00395	1.201e-07	61.0	2C2EP@1|root,33H2C@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2126477_1	330084.JNYZ01000039_gene3977	1.368e-107	353.0	COG0413@1|root,COG0413@2|Bacteria,2GJP6@201174|Actinobacteria,4DZTC@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TLS2_k127_2139765_1	1120950.KB892812_gene7002	9.816e-132	430.0	COG1226@1|root,COG1226@2|Bacteria,2GKB8@201174|Actinobacteria,4DPPQ@85009|Propionibacteriales	201174|Actinobacteria	P	Ion channel	kch	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
TLS2_k127_2139765_0	67332.FM21_00285	8.556e-137	442.0	COG0604@1|root,COG0604@2|Bacteria,2GN47@201174|Actinobacteria	201174|Actinobacteria	C	NAD(P)H quinone oxidoreductase, PIG3 family	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
TLS2_k127_2139765_2	110319.CF8_1692	1.619e-10	61.0	COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria,4DTG9@85009|Propionibacteriales	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
TLS2_k127_2151068_4	1288083.AUKR01000001_gene1053	8.817e-17	81.0	COG1122@1|root,COG1122@2|Bacteria,2GMK1@201174|Actinobacteria	201174|Actinobacteria	P	ECF transporter, substrate-specific component	-	-	-	ko:K16927	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.32	-	-	ECF_trnsprt
TLS2_k127_2151068_0	234621.RER_53580	4.037e-149	484.0	COG1235@1|root,COG2087@1|root,COG1235@2|Bacteria,COG2087@2|Bacteria,2GM8Q@201174|Actinobacteria,4FYZ7@85025|Nocardiaceae	201174|Actinobacteria	H	Adenosyl cobinamide kinase adenosyl cobinamide phosphate guanylyltransferase	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU,Lactamase_B_2
TLS2_k127_2151068_1	1123023.JIAI01000002_gene5177	1.076e-117	391.0	COG2038@1|root,COG2087@1|root,COG2038@2|Bacteria,COG2087@2|Bacteria,2GJ16@201174|Actinobacteria,4DX78@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2207	CobU,DBI_PRT
TLS2_k127_2151068_3	43354.JOIJ01000004_gene3651	2.283e-40	170.0	COG0368@1|root,COG0368@2|Bacteria,2GKM4@201174|Actinobacteria,4E2M6@85010|Pseudonocardiales	201174|Actinobacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
TLS2_k127_2151068_2	656024.FsymDg_3238	8.839e-51	192.0	COG5340@1|root,COG5340@2|Bacteria	656024.FsymDg_3238|-	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2173611_9	59538.XP_005976559.1	3.284e-05	48.0	COG4770@1|root,KOG0238@2759|Eukaryota,38B7N@33154|Opisthokonta,3CPST@33208|Metazoa,3E5XU@33213|Bilateria,48SHR@7711|Chordata,49P12@7742|Vertebrata,3JNZC@40674|Mammalia	33208|Metazoa	EI	Biotin carboxylase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
TLS2_k127_2173611_6	1120950.KB892785_gene224	8.88e-46	169.0	COG0789@1|root,COG0789@2|Bacteria,2IMV1@201174|Actinobacteria,4DUXA@85009|Propionibacteriales	201174|Actinobacteria	K	MerR, DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1
TLS2_k127_2173611_1	1380370.JIBA01000001_gene2171	3.335e-188	594.0	COG1960@1|root,COG1960@2|Bacteria,2GMEM@201174|Actinobacteria,4FEKW@85021|Intrasporangiaceae	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE19	GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681	1.3.8.1,1.3.99.12	ko:K00248,ko:K11410	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_2173611_0	1120950.KB892785_gene222	1.327e-267	840.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4DTHF@85009|Propionibacteriales	201174|Actinobacteria	I	Carboxyl transferase domain	yngE	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
TLS2_k127_2173611_2	1128421.JAGA01000003_gene3550	3.851e-168	542.0	COG0277@1|root,COG0277@2|Bacteria,2NQTQ@2323|unclassified Bacteria	2|Bacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_2173611_5	1193181.BN10_690004	1.795e-108	363.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4FFNS@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_2173611_7	446468.Ndas_4875	3.389e-20	98.0	COG1977@1|root,COG1977@2|Bacteria,2GQM9@201174|Actinobacteria	201174|Actinobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS2_k127_2173611_3	1343740.M271_42825	4.637e-160	518.0	COG4447@1|root,COG4447@2|Bacteria,2GM8J@201174|Actinobacteria	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR_6
TLS2_k127_2173611_4	1206732.BAGD01000065_gene2467	4.347e-123	402.0	COG0119@1|root,COG0119@2|Bacteria,2GKTP@201174|Actinobacteria,4FUUW@85025|Nocardiaceae	201174|Actinobacteria	E	Hydroxymethylglutaryl-CoA lyase	-	-	4.1.3.4,4.1.3.46	ko:K01640,ko:K18314	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090,R10674	RC00502,RC00503,RC01118,RC01205,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS2_k127_2173611_8	33898.JRHJ01000001_gene751	8.375e-13	69.0	COG1961@1|root,COG1961@2|Bacteria,2I8IZ@201174|Actinobacteria	201174|Actinobacteria	L	Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_2255071_7	101510.RHA1_ro05722	5.393e-72	248.0	COG5587@1|root,COG5587@2|Bacteria,2IJG5@201174|Actinobacteria,4FVR0@85025|Nocardiaceae	201174|Actinobacteria	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
TLS2_k127_2255071_9	1032480.MLP_28650	9.203e-55	204.0	COG1296@1|root,COG1296@2|Bacteria,2GN6R@201174|Actinobacteria,4DQH9@85009|Propionibacteriales	201174|Actinobacteria	E	AzlC protein	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
TLS2_k127_2255071_14	1463920.JOGB01000066_gene4257	2.777e-17	93.0	2E45J@1|root,32Z1K@2|Bacteria,2GR89@201174|Actinobacteria	201174|Actinobacteria	S	branched-chain amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
TLS2_k127_2255071_11	479435.Kfla_2963	2.642e-41	157.0	COG0457@1|root,COG0457@2|Bacteria,2I2JF@201174|Actinobacteria	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2255071_5	644283.Micau_1485	1.038e-101	336.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,4D8IW@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2773c	DapB_C,DapB_N
TLS2_k127_2255071_13	1184609.KILIM_076_00140	1.576e-22	107.0	COG2755@1|root,COG2755@2|Bacteria,2HPGJ@201174|Actinobacteria,4F7UG@85018|Dermatophilaceae	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS2_k127_2255071_1	1120950.KB892747_gene3684	5.922e-196	621.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4DNY1@85009|Propionibacteriales	201174|Actinobacteria	S	Insulinase (Peptidase family M16)	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_2255071_0	1380346.JNIH01000008_gene1319	0.0	1154.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria	201174|Actinobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TLS2_k127_2255071_10	1120950.KB892747_gene3686	7.75e-45	166.0	COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4DS16@85009|Propionibacteriales	201174|Actinobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
TLS2_k127_2255071_2	1121877.JQKF01000032_gene2046	5.022e-150	494.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4CNPH@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_2255071_4	1122609.AUGT01000022_gene718	6.002e-103	345.0	COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4DNXK@85009|Propionibacteriales	201174|Actinobacteria	H	Belongs to the ribF family	ribF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
TLS2_k127_2255071_3	1123320.KB889675_gene4019	3.632e-114	383.0	COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C,TruB_C_2,TruB_N
TLS2_k127_2255071_8	67281.JNZZ01000024_gene4802	4.358e-61	214.0	COG0858@1|root,COG0858@2|Bacteria,2IKXP@201174|Actinobacteria,41ATS@629295|Streptomyces griseus group	201174|Actinobacteria	J	Ribosome-binding factor A	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
TLS2_k127_2255071_12	1048339.KB913029_gene3566	6.146e-35	139.0	COG1550@1|root,COG1550@2|Bacteria,2IQW4@201174|Actinobacteria,4ET2E@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
TLS2_k127_2255071_6	1122130.AUHN01000006_gene2040	3.815e-101	332.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
TLS2_k127_2285741_0	1236902.ANAS01000001_gene1948	5.774e-253	791.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,GMC_oxred_C,GMC_oxred_N
TLS2_k127_2285741_1	1192034.CAP_8929	8.488e-98	323.0	COG0667@1|root,COG0667@2|Bacteria,1MU1S@1224|Proteobacteria,42YBD@68525|delta/epsilon subdivisions,2X27U@28221|Deltaproteobacteria,2YWHY@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_2395019_7	68219.JNXI01000004_gene2777	8.503e-58	202.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_2395019_1	351607.Acel_1042	1.136e-237	741.0	COG0402@1|root,COG0402@2|Bacteria,2GNUN@201174|Actinobacteria,4ESKE@85013|Frankiales	201174|Actinobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_2395019_4	351607.Acel_1041	1.035e-125	416.0	COG0662@1|root,COG0662@2|Bacteria,2GN99@201174|Actinobacteria	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2395019_5	351607.Acel_1040	3.023e-107	361.0	COG1028@1|root,COG1028@2|Bacteria,2I6UQ@201174|Actinobacteria,4EVQ5@85013|Frankiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
TLS2_k127_2395019_6	351607.Acel_1045	3.995e-76	267.0	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,4EWCI@85013|Frankiales	201174|Actinobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_2395019_3	469371.Tbis_2595	3.853e-128	439.0	COG2301@1|root,COG2301@2|Bacteria,2GNNK@201174|Actinobacteria,4E0B4@85010|Pseudonocardiales	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
TLS2_k127_2395019_2	1463856.JOHY01000011_gene7006	1.273e-182	592.0	COG4992@1|root,COG4992@2|Bacteria,2GK0J@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	rocD	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_2395019_8	1828.JOKB01000056_gene3244	1.21e-46	177.0	COG2839@1|root,COG2839@2|Bacteria,2IQDE@201174|Actinobacteria,4G1BR@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF456)	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
TLS2_k127_2395019_10	1122138.AQUZ01000016_gene201	8.072e-19	93.0	2E39Y@1|root,32Y9G@2|Bacteria,2GQJA@201174|Actinobacteria,4DSBB@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2395019_0	1306174.JODP01000013_gene7789	0.0	1022.0	COG0187@1|root,COG0187@2|Bacteria,2GM1E@201174|Actinobacteria	201174|Actinobacteria	L	DNA topoisomerase (ATP-hydrolyzing)	gyrB2	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS2_k127_2395019_9	222534.KB893783_gene5263	3.22e-27	124.0	2DRRW@1|root,33CSQ@2|Bacteria,2HU49@201174|Actinobacteria,4EWXU@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2416187_5	996637.SGM_2680	3.969e-32	134.0	COG2261@1|root,COG2261@2|Bacteria,2GQR5@201174|Actinobacteria	201174|Actinobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS2_k127_2416187_3	1121924.ATWH01000001_gene4430	8.858e-44	163.0	COG2315@1|root,COG2315@2|Bacteria,2I2W9@201174|Actinobacteria,4FQ8P@85023|Microbacteriaceae	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
TLS2_k127_2416187_2	1211815.CBYP010000021_gene3271	4.678e-45	171.0	COG0789@1|root,COG0789@2|Bacteria,2I9B3@201174|Actinobacteria,4EVW1@85013|Frankiales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_2416187_1	1121926.AXWO01000002_gene1433	2.444e-51	185.0	2CMJR@1|root,32SF0@2|Bacteria,2IQBS@201174|Actinobacteria,4EZTX@85014|Glycomycetales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2416187_4	1304865.JAGF01000001_gene2548	1.695e-39	155.0	COG4635@1|root,COG4635@2|Bacteria,2GTVT@201174|Actinobacteria	201174|Actinobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
TLS2_k127_2416187_0	561175.KB894098_gene5185	2.091e-132	435.0	COG1643@1|root,COG1643@2|Bacteria,2GIWX@201174|Actinobacteria,4EGY7@85012|Streptosporangiales	201174|Actinobacteria	L	Helicase associated domain (HA2)  Add an annotation	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
TLS2_k127_2426662_10	1120936.KB907218_gene3421	2.483e-21	94.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria,4EFGJ@85012|Streptosporangiales	201174|Actinobacteria	L	Formamidopyrimidine-DNA glycosylase N-terminal domain	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_2426662_5	1120950.KB892743_gene3110	1.162e-82	295.0	COG2360@1|root,COG2360@2|Bacteria,2IFT7@201174|Actinobacteria,4DQD7@85009|Propionibacteriales	201174|Actinobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
TLS2_k127_2426662_7	1120954.ATXE01000001_gene1800	5.53e-44	181.0	28MIG@1|root,2ZAV8@2|Bacteria,2IGFB@201174|Actinobacteria,4DQAF@85009|Propionibacteriales	201174|Actinobacteria	S	EcsC protein family	-	-	-	-	-	-	-	-	-	-	-	-	EcsC
TLS2_k127_2426662_2	882082.SaccyDRAFT_2387	1.797e-90	316.0	COG0384@1|root,COG0384@2|Bacteria,2GM1W@201174|Actinobacteria,4DZWT@85010|Pseudonocardiales	201174|Actinobacteria	J	TIGRFAM phenazine biosynthesis protein PhzF family	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
TLS2_k127_2426662_12	1095767.CAHD01000069_gene3156	1.124e-13	77.0	2EEMB@1|root,338F8@2|Bacteria,2GRKB@201174|Actinobacteria,4F1J3@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2426662_3	1146883.BLASA_0996	3.167e-90	310.0	COG1073@1|root,COG1073@2|Bacteria,2I9HJ@201174|Actinobacteria,4EV1B@85013|Frankiales	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071944,GO:0075136	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
TLS2_k127_2426662_11	258533.BN977_01568	3.686e-14	78.0	2CIG4@1|root,33C84@2|Bacteria,2GWMV@201174|Actinobacteria,23B9K@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2426662_4	479431.Namu_1277	1.686e-83	293.0	28P5T@1|root,2ZC0N@2|Bacteria,2GP34@201174|Actinobacteria,4ESCT@85013|Frankiales	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2426662_1	1120950.KB892731_gene3806	5.566e-125	431.0	COG0614@1|root,COG0614@2|Bacteria,2GM6R@201174|Actinobacteria,4DPTH@85009|Propionibacteriales	201174|Actinobacteria	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS2_k127_2426662_0	426716.JOAJ01000001_gene1429	5.756e-146	492.0	COG4097@1|root,COG4097@2|Bacteria,2H9AX@201174|Actinobacteria,4FVV7@85025|Nocardiaceae	201174|Actinobacteria	P	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_8,Ferric_reduct,NAD_binding_1
TLS2_k127_2426662_6	716928.AJQT01000008_gene2946	1.509e-44	166.0	COG3607@1|root,COG3607@2|Bacteria,1RH1T@1224|Proteobacteria,2U7DZ@28211|Alphaproteobacteria,4BFZN@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	glyoxalase bleomycin resistance protein	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_2426662_8	1179773.BN6_21980	2.814e-38	144.0	2DMTM@1|root,32TKZ@2|Bacteria,2IRRY@201174|Actinobacteria,4E60B@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2426662_9	1120949.KB903339_gene7951	1.98e-21	110.0	COG4928@1|root,COG4928@2|Bacteria,2IB3U@201174|Actinobacteria,4DEUM@85008|Micromonosporales	201174|Actinobacteria	S	KAP family P-loop domain	-	-	-	-	-	-	-	-	-	-	-	-	KAP_NTPase,WD40
TLS2_k127_2462243_2	1120950.KB892823_gene459	1.504e-83	300.0	COG3396@1|root,COG3396@2|Bacteria,2GKXZ@201174|Actinobacteria,4DMYE@85009|Propionibacteriales	201174|Actinobacteria	S	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like	-	-	-	-	-	-	-	-	-	-	-	-	MiaE_2
TLS2_k127_2462243_0	1048339.KB913029_gene2909	6.949e-192	618.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4ERIC@85013|Frankiales	201174|Actinobacteria	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
TLS2_k127_2462243_3	1122609.AUGT01000015_gene2004	3.988e-43	168.0	COG1376@1|root,COG1376@2|Bacteria,2IIU7@201174|Actinobacteria,4DRAD@85009|Propionibacteriales	201174|Actinobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS2_k127_2462243_1	656024.FsymDg_0894	3.607e-99	332.0	COG1192@1|root,COG1192@2|Bacteria,2GNEQ@201174|Actinobacteria	201174|Actinobacteria	D	Cobyrinic acid ac-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS2_k127_2488955_7	1122214.AQWH01000001_gene724	2.504e-10	69.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2TSAD@28211|Alphaproteobacteria,2PKM6@255475|Aurantimonadaceae	28211|Alphaproteobacteria	G	Fructose-bisphosphate aldolase class-II	cbbA	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
TLS2_k127_2488955_4	1463903.JOIZ01000022_gene6156	9.647e-44	167.0	COG5006@1|root,COG5006@2|Bacteria,2GJKB@201174|Actinobacteria	201174|Actinobacteria	K	permease, DMT superfamily	rhtA_1	-	-	ko:K11939	-	-	-	-	ko00000,ko02000	2.A.7.3.6	-	-	EamA
TLS2_k127_2488955_6	390989.JOEG01000028_gene5561	2.672e-12	78.0	2B18C@1|root,31TNT@2|Bacteria,2GSR4@201174|Actinobacteria,4DFJI@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2488955_3	1120949.KB903295_gene2386	2.054e-82	276.0	COG0346@1|root,COG0346@2|Bacteria,2HKRN@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_2488955_2	1120949.KB903295_gene2385	1.371e-88	308.0	29ZNQ@1|root,30MP9@2|Bacteria,2IJUR@201174|Actinobacteria	201174|Actinobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS2_k127_2488955_1	391735.Veis_4611	4.275e-92	315.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2VM53@28216|Betaproteobacteria,4ACE5@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM iron-containing alcohol dehydrogenase	macA	-	1.3.1.32	ko:K00217	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	-	R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224	RC00107,RC01335,RC01689,RC02442	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
TLS2_k127_2488955_0	1120950.KB892750_gene6897	1.046e-103	347.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_2488955_5	882082.SaccyDRAFT_3521	6.806e-23	102.0	COG0262@1|root,COG0262@2|Bacteria,2GYU7@201174|Actinobacteria,4E52A@85010|Pseudonocardiales	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_2488955_8	1121019.AUMN01000014_gene4196	5.258e-05	49.0	COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria	201174|Actinobacteria	V	HNH endonuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_25001_0	1134445.AJJM01000024_gene4302	1.039e-131	426.0	COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria	201174|Actinobacteria	D	anion-transporting ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
TLS2_k127_25001_2	566461.SSFG_03279	1.97e-43	176.0	2CC1Y@1|root,32TCV@2|Bacteria,2IQEP@201174|Actinobacteria	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	wblA	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS2_k127_25001_1	1120950.KB892762_gene5499	5.474e-91	311.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4DPA4@85009|Propionibacteriales	201174|Actinobacteria	M	Transglycosylase	pon1	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
TLS2_k127_2503336_3	414996.IL38_01165	1.569e-05	47.0	COG3012@1|root,COG3012@2|Bacteria,2GJ7F@201174|Actinobacteria,40883@622450|Actinopolysporales	201174|Actinobacteria	S	SEC-C motif	-	-	-	-	-	-	-	-	-	-	-	-	SEC-C
TLS2_k127_2503336_2	1123320.KB889730_gene5911	7.625e-26	113.0	COG3920@1|root,COG3920@2|Bacteria,2II0F@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
TLS2_k127_2503336_0	1122138.AQUZ01000036_gene5429	9.622e-104	344.0	COG0584@1|root,COG0584@2|Bacteria,2GMMS@201174|Actinobacteria,4DNRE@85009|Propionibacteriales	201174|Actinobacteria	C	Glycerophosphoryl diester phosphodiesterase family	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS2_k127_2503336_1	298654.FraEuI1c_5630	1.964e-102	346.0	COG0277@1|root,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria,4ESN2@85013|Frankiales	201174|Actinobacteria	C	PFAM FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_250967_0	1089455.MOPEL_080_00430	0.0	1154.0	COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,2GIZP@201174|Actinobacteria,4F7M0@85018|Dermatophilaceae	201174|Actinobacteria	I	Acetyl-CoA carboxylase, central region	-	-	-	-	-	-	-	-	-	-	-	-	ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
TLS2_k127_250967_5	234267.Acid_3076	8.135e-32	141.0	COG2091@1|root,COG2091@2|Bacteria,3Y8HB@57723|Acidobacteria	57723|Acidobacteria	H	4'-phosphopantetheinyl transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_250967_4	1151119.KB895493_gene1342	4.809e-42	164.0	COG4635@1|root,COG4635@2|Bacteria,2INN9@201174|Actinobacteria	201174|Actinobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
TLS2_k127_250967_6	43354.JOIJ01000016_gene1122	2.372e-29	127.0	2AKF7@1|root,31B6Q@2|Bacteria,2ICG7@201174|Actinobacteria,4E8NH@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_250967_7	1120950.KB892830_gene5046	1.8e-24	117.0	COG2524@1|root,COG2524@2|Bacteria,2I1DT@201174|Actinobacteria,4DWBB@85009|Propionibacteriales	201174|Actinobacteria	K	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_250967_2	66429.JOFL01000020_gene5547	3.731e-124	406.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria	201174|Actinobacteria	M	Capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
TLS2_k127_250967_8	28444.JODQ01000007_gene5726	4.56e-19	100.0	2BEKK@1|root,328C2@2|Bacteria,2HE4G@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_250967_1	298654.FraEuI1c_6753	1.11e-163	541.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_250967_3	298655.KI912266_gene803	4.518e-98	325.0	COG2197@1|root,COG2197@2|Bacteria,2IFE7@201174|Actinobacteria,4ESS5@85013|Frankiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_2511809_1	1380390.JIAT01000009_gene1877	6.386e-110	374.0	COG2208@1|root,COG2208@2|Bacteria,2GNAF@201174|Actinobacteria,4CR74@84995|Rubrobacteria	84995|Rubrobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,SpoIIE
TLS2_k127_2511809_0	269800.Tfu_2441	7.992e-174	566.0	COG1840@1|root,COG2304@1|root,COG1840@2|Bacteria,COG2304@2|Bacteria,2GNSN@201174|Actinobacteria,4EH2B@85012|Streptosporangiales	201174|Actinobacteria	P	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	SBP_bac_11,VWA,VWA_2
TLS2_k127_2511809_3	35754.JNYJ01000005_gene5499	7.395e-13	78.0	2FIZ9@1|root,34AQ2@2|Bacteria,2INWA@201174|Actinobacteria,4DIXT@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2511809_2	512565.AMIS_17920	2.293e-97	331.0	COG1524@1|root,COG1950@1|root,COG1524@2|Bacteria,COG1950@2|Bacteria,2HH0Q@201174|Actinobacteria,4DAQP@85008|Micromonosporales	201174|Actinobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_4_2,Phosphodiest
TLS2_k127_2515916_9	1120950.KB892760_gene5758	8.231e-69	247.0	COG1686@1|root,COG1686@2|Bacteria,2GK3M@201174|Actinobacteria,4DTSB@85009|Propionibacteriales	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	dac	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
TLS2_k127_2515916_8	1120950.KB892760_gene5759	9.283e-96	323.0	COG1171@1|root,COG1171@2|Bacteria,2GKCC@201174|Actinobacteria,4DQ9J@85009|Propionibacteriales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_2515916_6	479435.Kfla_1337	1.371e-131	424.0	COG0479@1|root,COG0479@2|Bacteria,2GJPS@201174|Actinobacteria,4DPU6@85009|Propionibacteriales	201174|Actinobacteria	C	Succinate dehydrogenase fumarate reductase	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
TLS2_k127_2515916_1	479435.Kfla_1338	0.0	1020.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4DPTE@85009|Propionibacteriales	201174|Actinobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_2515916_10	266940.Krad_3953	4.129e-59	215.0	COG2142@1|root,COG2142@2|Bacteria,2GNKE@201174|Actinobacteria	201174|Actinobacteria	C	succinate dehydrogenase	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS2_k127_2515916_11	479435.Kfla_1340	1.821e-57	204.0	COG2009@1|root,COG2009@2|Bacteria,2IKU7@201174|Actinobacteria	201174|Actinobacteria	C	succinate dehydrogenase	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS2_k127_2515916_4	397278.JOJN01000004_gene1567	1.269e-150	482.0	COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria,4DP3U@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	fgd	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0019725,GO:0030312,GO:0031406,GO:0036094,GO:0042592,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0046983,GO:0048037,GO:0050662,GO:0050789,GO:0050794,GO:0055114,GO:0065007,GO:0065008,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363	1.1.98.2	ko:K15510	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
TLS2_k127_2515916_0	1123024.AUII01000021_gene79	0.0	1207.0	COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4DX6M@85010|Pseudonocardiales	201174|Actinobacteria	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
TLS2_k127_2515916_12	1120950.KB892773_gene1057	5.384e-30	120.0	COG4281@1|root,COG4281@2|Bacteria,2GS11@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ACBP
TLS2_k127_2515916_2	68199.JNZO01000012_gene3158	1.034e-270	844.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	bhbA	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS2_k127_2515916_3	1120950.KB892760_gene5781	9.449e-161	516.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4DN6X@85009|Propionibacteriales	201174|Actinobacteria	S	Peptidase family M20/M25/M40	amiA	-	-	ko:K01436,ko:K06048	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_2515916_7	1122933.JNIY01000003_gene854	3.795e-122	401.0	COG1744@1|root,COG1744@2|Bacteria,2GMFS@201174|Actinobacteria,4F0NG@85016|Cellulomonadaceae	201174|Actinobacteria	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
TLS2_k127_2515916_5	446466.Cfla_1021	2.927e-133	432.0	COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria,4F0DM@85016|Cellulomonadaceae	201174|Actinobacteria	S	ABC transporter	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TLS2_k127_252624_0	1032480.MLP_51790	1e-323	1017.0	COG2909@1|root,COG2909@2|Bacteria,2I50W@201174|Actinobacteria,4DPMG@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE
TLS2_k127_252624_4	1172188.KB911827_gene4300	3.615e-79	274.0	2950P@1|root,2ZSDF@2|Bacteria,2IIVU@201174|Actinobacteria,4FH7H@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_252624_3	1122609.AUGT01000013_gene4107	2.432e-87	298.0	COG5395@1|root,COG5395@2|Bacteria,2IHVI@201174|Actinobacteria,4DQNA@85009|Propionibacteriales	201174|Actinobacteria	S	Predicted membrane protein (DUF2306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2306
TLS2_k127_252624_2	1385520.N802_06780	5.265e-91	311.0	COG1670@1|root,COG1670@2|Bacteria,2IIYT@201174|Actinobacteria,4FGR2@85021|Intrasporangiaceae	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_252624_5	1122138.AQUZ01000019_gene8185	1.895e-77	270.0	COG2267@1|root,COG2267@2|Bacteria,2GJUE@201174|Actinobacteria,4DQUJ@85009|Propionibacteriales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_252624_6	485913.Krac_6522	1.571e-14	80.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_252624_1	1223523.H340_11710	1.133e-133	452.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,NB-ARC,TPR_12,Trans_reg_C
TLS2_k127_2568972_3	367299.JOEE01000011_gene3164	1.003e-06	53.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	PD40,WD40
TLS2_k127_2568972_0	266940.Krad_3392	2.106e-167	539.0	COG1363@1|root,COG1363@2|Bacteria,2ICG5@201174|Actinobacteria	201174|Actinobacteria	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
TLS2_k127_2568972_2	1298863.AUEP01000002_gene1490	3.226e-13	83.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4DNYQ@85009|Propionibacteriales	201174|Actinobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	-	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS2_k127_2568972_1	37919.EP51_00200	5.635e-57	207.0	COG1309@1|root,COG1309@2|Bacteria,2IFH9@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_2581129_26	1385520.N802_02110	1.326e-05	55.0	COG2382@1|root,COG2382@2|Bacteria,2HZ1I@201174|Actinobacteria,4FEYB@85021|Intrasporangiaceae	201174|Actinobacteria	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
TLS2_k127_2581129_16	479435.Kfla_0874	2.489e-121	393.0	COG4947@1|root,COG4947@2|Bacteria,2I9H9@201174|Actinobacteria,4DNJ6@85009|Propionibacteriales	201174|Actinobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
TLS2_k127_2581129_14	1385519.N801_12160	7.016e-141	461.0	COG1830@1|root,COG1830@2|Bacteria,2HPYX@201174|Actinobacteria,4FJTZ@85021|Intrasporangiaceae	201174|Actinobacteria	G	DeoC/LacD family aldolase	-	-	-	-	-	-	-	-	-	-	-	-	DeoC
TLS2_k127_2581129_8	1380393.JHVP01000005_gene3593	3.266e-204	648.0	COG1181@1|root,COG1181@2|Bacteria,2HP1M@201174|Actinobacteria,4EV01@85013|Frankiales	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	-	-	-	-	-	-	-	-	-	-	-	-	Dala_Dala_lig_C
TLS2_k127_2581129_25	1172179.AUKV01000023_gene2068	8.567e-21	94.0	COG0517@1|root,COG0517@2|Bacteria,2IM3K@201174|Actinobacteria	201174|Actinobacteria	S	Cbs domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_2581129_1	479435.Kfla_4953	0.0	1182.0	COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,4DPZS@85009|Propionibacteriales	201174|Actinobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TLS2_k127_2581129_13	1120950.KB892798_gene2194	8.313e-142	465.0	COG3281@1|root,COG3281@2|Bacteria,2GKAP@201174|Actinobacteria,4DNWM@85009|Propionibacteriales	201174|Actinobacteria	G	protein probably involved in trehalose biosynthesis	mak	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576	2.7.1.175	ko:K16146	ko00500,ko01100,map00500,map01100	-	R09945	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
TLS2_k127_2581129_2	1120950.KB892798_gene2195	0.0	1029.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria,4DNMJ@85009|Propionibacteriales	201174|Actinobacteria	G	Trehalose synthase	treS	GO:0000023,GO:0000271,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016160,GO:0016161,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046872,GO:0047471,GO:0055114,GO:0071704,GO:0071944,GO:1901576	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	iNJ661.Rv0126	Alpha-amylase,Malt_amylase_C
TLS2_k127_2581129_5	1157637.KB892146_gene7086	1.594e-289	901.0	COG0366@1|root,COG0366@2|Bacteria,2GJKR@201174|Actinobacteria	201174|Actinobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
TLS2_k127_2581129_22	471853.Bcav_1237	5.947e-47	183.0	COG2852@1|root,COG2852@2|Bacteria,2GNZQ@201174|Actinobacteria	201174|Actinobacteria	K	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
TLS2_k127_2581129_0	1120950.KB892798_gene2197	0.0	1257.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria,4DPQE@85009|Propionibacteriales	201174|Actinobacteria	G	Protein of unknown function (DUF3417)	glgP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
TLS2_k127_2581129_4	1123320.KB889709_gene8414	7.876e-305	949.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX2	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS2_k127_2581129_17	1123320.KB889709_gene8418	3.809e-115	381.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA17	GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_2581129_12	1120950.KB892741_gene2633	1.575e-148	481.0	COG0500@1|root,COG2226@2|Bacteria,2GK7A@201174|Actinobacteria,4DP7U@85009|Propionibacteriales	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_2581129_20	675635.Psed_1741	4.532e-96	321.0	COG0110@1|root,COG0110@2|Bacteria,2GNUB@201174|Actinobacteria,4DZBZ@85010|Pseudonocardiales	201174|Actinobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
TLS2_k127_2581129_9	1120934.KB894408_gene4901	1.079e-183	588.0	COG1543@1|root,COG1543@2|Bacteria,2GKTI@201174|Actinobacteria,4DZYG@85010|Pseudonocardiales	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
TLS2_k127_2581129_18	1172188.KB911821_gene1538	1.436e-111	367.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,4FEFQ@85021|Intrasporangiaceae	201174|Actinobacteria	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
TLS2_k127_2581129_15	1033730.CAHG01000013_gene1266	2.593e-129	420.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,4DNKA@85009|Propionibacteriales	201174|Actinobacteria	C	electron transfer flavoprotein, alpha subunit	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TLS2_k127_2581129_10	1120950.KB892741_gene2649	7.385e-168	547.0	COG1104@1|root,COG1104@2|Bacteria,2GKUT@201174|Actinobacteria,4DNQT@85009|Propionibacteriales	201174|Actinobacteria	E	Aminotransferase class-V	iscS	GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS2_k127_2581129_11	351607.Acel_0689	7.287e-163	541.0	COG0482@1|root,COG0482@2|Bacteria,2GIUQ@201174|Actinobacteria,4ERNJ@85013|Frankiales	201174|Actinobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TLS2_k127_2581129_19	1120950.KB892741_gene2651	1.116e-102	348.0	COG0620@1|root,COG0620@2|Bacteria,2GMPS@201174|Actinobacteria,4DN0J@85009|Propionibacteriales	201174|Actinobacteria	E	Methionine synthase, vitamin-B12 independent	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
TLS2_k127_2581129_3	1114959.SZMC14600_04618	4.88e-314	990.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,4E0P6@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
TLS2_k127_2581129_21	1114959.SZMC14600_04603	1.032e-57	208.0	COG0317@1|root,COG0317@2|Bacteria,2GNRE@201174|Actinobacteria,4E103@85010|Pseudonocardiales	201174|Actinobacteria	KT	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
TLS2_k127_2581129_6	1449355.JQNR01000005_gene4553	1.89e-264	826.0	COG0154@1|root,COG5001@1|root,COG0154@2|Bacteria,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria	201174|Actinobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
TLS2_k127_2581129_27	749414.SBI_03573	0.0005849	51.0	2C7EP@1|root,2ZXNX@2|Bacteria,2IQ7Y@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2581129_7	397278.JOJN01000001_gene2800	6.054e-238	746.0	COG0064@1|root,COG0064@2|Bacteria,2GJJH@201174|Actinobacteria,4DNB4@85009|Propionibacteriales	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
TLS2_k127_2581129_24	479435.Kfla_1651	1.964e-22	108.0	COG3595@1|root,COG3595@2|Bacteria,2HUCU@201174|Actinobacteria,4DW5Y@85009|Propionibacteriales	201174|Actinobacteria	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS2_k127_2581129_23	2002.JOEQ01000041_gene6017	1.881e-38	146.0	COG2133@1|root,COG2133@2|Bacteria,2GISM@201174|Actinobacteria,4EFX1@85012|Streptosporangiales	201174|Actinobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,GSDH
TLS2_k127_2597283_0	1120950.KB892707_gene4731	1.893e-258	801.0	COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria,4DNNP@85009|Propionibacteriales	201174|Actinobacteria	E	glutamine synthetase	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS2_k127_2597283_2	471853.Bcav_3329	1.086e-44	172.0	COG4319@1|root,COG4319@2|Bacteria,2IRHC@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS2_k127_2597283_1	67373.JOBF01000003_gene56	1.109e-252	791.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2GK2C@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
TLS2_k127_2597283_4	1869.MB27_16300	1.182e-25	110.0	COG0413@1|root,COG0413@2|Bacteria,2GJP6@201174|Actinobacteria,4DBBA@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TLS2_k127_2603629_12	526225.Gobs_2306	2.829e-36	149.0	COG1266@1|root,COG1266@2|Bacteria,2GKRA@201174|Actinobacteria,4EVQR@85013|Frankiales	201174|Actinobacteria	S	Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_2603629_7	1133849.O3I_017120	1.282e-66	233.0	COG3832@1|root,COG3832@2|Bacteria,2IHY4@201174|Actinobacteria,4G1HM@85025|Nocardiaceae	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_2603629_10	1283283.ATXA01000008_gene2991	1.185e-46	169.0	2BG73@1|root,32A40@2|Bacteria,2GPJQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2603629_8	477641.MODMU_1573	2.451e-63	223.0	COG0454@1|root,COG0456@2|Bacteria,2HUG3@201174|Actinobacteria,4EWZV@85013|Frankiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
TLS2_k127_2603629_6	1394178.AWOO02000014_gene7733	1.167e-76	260.0	COG2227@1|root,COG2227@2|Bacteria,2HF1Q@201174|Actinobacteria,4EMG9@85012|Streptosporangiales	201174|Actinobacteria	H	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_2603629_13	1273125.Rrhod_4458	2.179e-35	143.0	COG1863@1|root,COG1863@2|Bacteria,2IRM2@201174|Actinobacteria	201174|Actinobacteria	P	Na+/H+ ion antiporter subunit	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
TLS2_k127_2603629_2	1292020.H483_0101845	3.01e-178	600.0	COG0651@1|root,COG0651@2|Bacteria,2IB44@201174|Actinobacteria	201174|Actinobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
TLS2_k127_2603629_1	1292020.H483_0101840	1.115e-184	616.0	COG0651@1|root,COG0651@2|Bacteria,2I6CT@201174|Actinobacteria	201174|Actinobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
TLS2_k127_2603629_4	443218.AS9A_1552	4.757e-138	461.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria,235AZ@1762|Mycobacteriaceae	201174|Actinobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
TLS2_k127_2603629_14	443218.AS9A_1551	1.372e-25	110.0	COG1006@1|root,COG1006@2|Bacteria,2GSHQ@201174|Actinobacteria	201174|Actinobacteria	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
TLS2_k127_2603629_9	1273125.Rrhod_4463	2.257e-61	230.0	COG2111@1|root,COG2111@2|Bacteria	2|Bacteria	P	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	DUF4040,MnhB
TLS2_k127_2603629_15	443218.AS9A_1549	1.301e-21	101.0	COG1320@1|root,COG1320@2|Bacteria,2GQG4@201174|Actinobacteria	201174|Actinobacteria	P	monovalent cation proton antiporter, MnhG PhaG subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
TLS2_k127_2603629_16	266117.Rxyl_3191	8.269e-18	93.0	COG1917@1|root,COG1917@2|Bacteria,2I5JH@201174|Actinobacteria,4CTYM@84995|Rubrobacteria	84995|Rubrobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2603629_19	525368.HMPREF0591_4152	1.138e-05	54.0	COG0662@1|root,COG0662@2|Bacteria,2IEY0@201174|Actinobacteria,237AC@1762|Mycobacteriaceae	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2603629_5	1394178.AWOO02000012_gene3773	4.445e-112	382.0	COG2909@1|root,COG2909@2|Bacteria,2I3S2@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_2603629_3	1108045.GORHZ_154_00260	1.839e-155	499.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4GGGG@85026|Gordoniaceae	201174|Actinobacteria	P	Flavin-binding monooxygenase-like	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS2_k127_2603629_11	446471.Xcel_1410	3.24e-46	181.0	2DM4W@1|root,31QNY@2|Bacteria,2IK0R@201174|Actinobacteria,4F4T1@85017|Promicromonosporaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS2_k127_2603629_0	103733.JNYO01000003_gene8218	4.85e-282	878.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4E01V@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type multidrug transport system, ATPase and permease	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS2_k127_2606090_2	994479.GL877879_gene6142	8.681e-70	242.0	COG2733@1|root,COG2733@2|Bacteria,2GKGM@201174|Actinobacteria,4DYTZ@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
TLS2_k127_2606090_3	42256.RradSPS_0150	3.702e-48	185.0	COG0572@1|root,COG0572@2|Bacteria,2HQC8@201174|Actinobacteria	201174|Actinobacteria	F	belongs to the nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18,Cytidylate_kin
TLS2_k127_2606090_1	391037.Sare_4405	4.572e-143	464.0	COG3616@1|root,COG3616@2|Bacteria,2GJMB@201174|Actinobacteria,4D9J1@85008|Micromonosporales	201174|Actinobacteria	E	Alanine racemase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N
TLS2_k127_2606090_0	479432.Sros_0566	3.892e-186	589.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4EI7A@85012|Streptosporangiales	201174|Actinobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS2_k127_2607906_5	101510.RHA1_ro02392	3.011e-140	449.0	COG0500@1|root,COG2226@2|Bacteria,2GM2N@201174|Actinobacteria,4FX7V@85025|Nocardiaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_2607906_9	644283.Micau_1426	5.515e-107	351.0	COG1733@1|root,COG1733@2|Bacteria,2GMK5@201174|Actinobacteria,4DB8G@85008|Micromonosporales	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR,SCP2
TLS2_k127_2607906_4	446469.Sked_04560	4.771e-146	467.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	1.14.14.5	ko:K04091	ko00920,map00920	-	R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
TLS2_k127_2607906_1	543632.JOJL01000004_gene4302	1.263e-222	699.0	COG1239@1|root,COG1239@2|Bacteria,2GMRS@201174|Actinobacteria,4D8T3@85008|Micromonosporales	201174|Actinobacteria	H	Mg-chelatase subunit ChlI	chlI	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0958	Mg_chelatase,Sigma54_activat
TLS2_k127_2607906_0	1120950.KB892709_gene4123	1.654e-292	928.0	COG4867@1|root,COG4867@2|Bacteria,2H14W@201174|Actinobacteria,4DNMK@85009|Propionibacteriales	201174|Actinobacteria	S	von Willebrand factor (vWF) type A domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	VWA_2
TLS2_k127_2607906_7	1150864.MILUP08_45428	3.932e-122	403.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,4DCDB@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
TLS2_k127_2607906_2	1385519.N801_07315	5.057e-178	592.0	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria,4FGDV@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_2607906_8	1120950.KB892779_gene860	8.187e-114	373.0	COG0330@1|root,COG0330@2|Bacteria,2GKFP@201174|Actinobacteria,4DTAB@85009|Propionibacteriales	201174|Actinobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_2607906_10	101510.RHA1_ro04932	3.541e-95	316.0	COG3145@1|root,COG3145@2|Bacteria,2GNBD@201174|Actinobacteria,4FVRU@85025|Nocardiaceae	201174|Actinobacteria	L	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
TLS2_k127_2607906_12	1122933.JNIY01000003_gene63	6.335e-71	266.0	COG4894@1|root,COG4894@2|Bacteria,2GKWI@201174|Actinobacteria	201174|Actinobacteria	S	LURP-one-related	-	-	-	-	-	-	-	-	-	-	-	-	LOR
TLS2_k127_2607906_15	981369.JQMJ01000004_gene461	1.534e-46	174.0	COG0716@1|root,COG0716@2|Bacteria,2IQZD@201174|Actinobacteria,2NMDZ@228398|Streptacidiphilus	201174|Actinobacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Flavodoxin_5
TLS2_k127_2607906_11	1283283.ATXA01000004_gene4398	6.611e-89	302.0	2DBXI@1|root,2ZBQ3@2|Bacteria,2GJN1@201174|Actinobacteria,4EU56@85013|Frankiales	201174|Actinobacteria	S	Peptidase M50B-like	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50B
TLS2_k127_2607906_3	1968.JOEV01000026_gene5497	2.54e-159	515.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2607906_16	391037.Sare_0955	8.402e-44	172.0	COG3795@1|root,COG3795@2|Bacteria,2IQKK@201174|Actinobacteria,4DEYD@85008|Micromonosporales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_2607906_14	1442599.JAAN01000026_gene1300	3.112e-50	201.0	COG2050@1|root,COG2050@2|Bacteria,1RH0Z@1224|Proteobacteria,1S5W6@1236|Gammaproteobacteria,1X6FN@135614|Xanthomonadales	135614|Xanthomonadales	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4442
TLS2_k127_2607906_6	390989.JOEG01000006_gene832	3.697e-140	460.0	COG0849@1|root,COG0849@2|Bacteria,2GK4G@201174|Actinobacteria,4D9C9@85008|Micromonosporales	201174|Actinobacteria	D	MutL protein	mutL	-	-	-	-	-	-	-	-	-	-	-	MutL
TLS2_k127_2607906_13	711393.AYRX01000004_gene4120	1.127e-53	190.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1079	Cys_Met_Meta_PP
TLS2_k127_2613378_3	479435.Kfla_3319	3.765e-124	404.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,4DNFS@85009|Propionibacteriales	201174|Actinobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
TLS2_k127_2613378_0	55952.BU52_00200	1.619e-235	742.0	COG0296@1|root,COG0296@2|Bacteria,2GMIS@201174|Actinobacteria	201174|Actinobacteria	G	4-alpha-D-((1- 4)-alpha-D-glucano)trehalose trehalohydrolase	treZ	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0033942,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0071704,GO:1901575,GO:1901576	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
TLS2_k127_2613378_5	1172188.KB911821_gene1805	2.029e-70	242.0	COG1803@1|root,COG1803@2|Bacteria,2IMPC@201174|Actinobacteria	201174|Actinobacteria	G	MGS-like domain	mgsA	-	4.2.3.3	ko:K01734	ko00640,ko01120,map00640,map01120	-	R01016	RC00424	ko00000,ko00001,ko01000	-	-	-	MGS
TLS2_k127_2613378_2	1123322.KB904658_gene1205	3.667e-151	486.0	COG1485@1|root,COG1485@2|Bacteria,2GNQA@201174|Actinobacteria	201174|Actinobacteria	S	PFAM AFG1-family ATPase	-	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
TLS2_k127_2613378_6	1123320.KB889576_gene1980	2.023e-63	225.0	COG1985@1|root,COG1985@2|Bacteria,2GN2P@201174|Actinobacteria	201174|Actinobacteria	H	Pyrimidine reductase, riboflavin biosynthesis	-	-	1.1.1.193	ko:K00082	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R03458	RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C
TLS2_k127_2613378_1	67352.JODS01000018_gene5776	4.866e-156	499.0	COG1793@1|root,COG1793@2|Bacteria,2I2EA@201174|Actinobacteria	201174|Actinobacteria	L	dna ligase	ligC	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
TLS2_k127_2613378_7	1120950.KB892748_gene3264	7.804e-46	171.0	2AQ7N@1|root,31FDD@2|Bacteria,2IFXR@201174|Actinobacteria,4DRWQ@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2613378_4	1304865.JAGF01000001_gene703	1.93e-81	287.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein	txlA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,SfLAP,Thioredoxin
TLS2_k127_2687673_1	1386089.N865_14635	5.7e-159	510.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4FEBS@85021|Intrasporangiaceae	201174|Actinobacteria	E	glycine cleavage system	gcvT	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TLS2_k127_2687673_0	1048339.KB913029_gene4651	2.419e-171	555.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4ERDZ@85013|Frankiales	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS2_k127_2687673_2	1120950.KB892707_gene4758	1.897e-15	76.0	2E6TR@1|root,331DK@2|Bacteria,2IQF8@201174|Actinobacteria,4DRU0@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2729294_1	266117.Rxyl_2410	2.653e-155	499.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4CPCB@84995|Rubrobacteria	84995|Rubrobacteria	EQ	Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
TLS2_k127_2729294_0	42256.RradSPS_2485	8.053e-238	747.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4CRNM@84995|Rubrobacteria	84995|Rubrobacteria	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
TLS2_k127_2729294_3	479434.Sthe_0994	1.008e-82	279.0	COG0262@1|root,COG0262@2|Bacteria,2G8NF@200795|Chloroflexi	200795|Chloroflexi	H	PFAM bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_2729294_2	298653.Franean1_2313	1.49e-109	361.0	28KUD@1|root,2ZAB6@2|Bacteria,2IACK@201174|Actinobacteria,4EUQM@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2736338_1	1048339.KB913029_gene3458	2.251e-113	391.0	COG2133@1|root,COG2133@2|Bacteria,2GISM@201174|Actinobacteria,4ES6J@85013|Frankiales	201174|Actinobacteria	G	Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS2_k127_2736338_2	397278.JOJN01000001_gene2792	5.452e-76	270.0	COG2267@1|root,COG2267@2|Bacteria,2I9N6@201174|Actinobacteria,4DNRK@85009|Propionibacteriales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_2736338_0	1120950.KB892741_gene2668	1.325e-121	398.0	COG0111@1|root,COG0111@2|Bacteria,2GP09@201174|Actinobacteria,4DNYY@85009|Propionibacteriales	201174|Actinobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	pdxB	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_2736338_3	1306174.JODP01000031_gene4004	1.719e-05	46.0	COG2138@1|root,COG2138@2|Bacteria,2GNJ0@201174|Actinobacteria	201174|Actinobacteria	I	cobalamin (vitamin B12) biosynthesis CbiX protein	sirB	-	-	-	-	-	-	-	-	-	-	-	CbiX
TLS2_k127_2805541_2	591157.SSLG_06070	2.818e-78	276.0	COG1125@1|root,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	opuCA	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran
TLS2_k127_2805541_1	1288083.AUKR01000019_gene134	2.108e-82	288.0	COG1174@1|root,COG1174@2|Bacteria,2GMU0@201174|Actinobacteria	201174|Actinobacteria	E	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
TLS2_k127_2805541_3	1449353.JQMQ01000005_gene3320	8.654e-73	265.0	COG1174@1|root,COG1174@2|Bacteria,2GYTC@201174|Actinobacteria,2NHMW@228398|Streptacidiphilus	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	proW	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
TLS2_k127_2805541_0	500153.JOEK01000001_gene3538	6.442e-102	342.0	COG1732@1|root,COG1732@2|Bacteria,2GJWY@201174|Actinobacteria	201174|Actinobacteria	M	Glycine betaine	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
TLS2_k127_2805541_4	1713.JOFV01000001_gene1812	1.449e-72	254.0	COG3358@1|root,COG3358@2|Bacteria,2GP66@201174|Actinobacteria,4F2FB@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
TLS2_k127_2806944_3	1157632.AQWQ01000008_gene5112	1.65e-27	115.0	COG1522@1|root,COG1522@2|Bacteria,2IFSQ@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS2_k127_2806944_0	485913.Krac_4995	4.597e-90	318.0	COG1167@1|root,COG1167@2|Bacteria,2G5XE@200795|Chloroflexi	200795|Chloroflexi	K	COGs COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
TLS2_k127_2806944_2	1435356.Y013_03020	3.315e-60	220.0	COG3467@1|root,COG3467@2|Bacteria,2GJ76@201174|Actinobacteria,4FVGK@85025|Nocardiaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
TLS2_k127_2806944_1	882083.SacmaDRAFT_3224	3.977e-62	224.0	COG1309@1|root,COG1309@2|Bacteria,2GM45@201174|Actinobacteria,4E3QE@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
TLS2_k127_2813216_2	1380356.JNIK01000020_gene1326	1.169e-85	286.0	COG0367@1|root,COG0367@2|Bacteria,2GJIM@201174|Actinobacteria,4ERY2@85013|Frankiales	201174|Actinobacteria	E	asparagine	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
TLS2_k127_2813216_0	526225.Gobs_5017	2.4e-242	766.0	COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,2GN0U@201174|Actinobacteria,4ET1C@85013|Frankiales	201174|Actinobacteria	HJK	D-ala D-ala ligase C-terminus	cphA	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Dala_Dala_lig_C,Mur_ligase_C,Mur_ligase_M,RimK
TLS2_k127_2813216_4	479433.Caci_7402	1.133e-23	105.0	COG0642@1|root,COG2205@2|Bacteria,2GM17@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	mprB	GO:0000160,GO:0003674,GO:0003824,GO:0004721,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023052,GO:0035556,GO:0036211,GO:0040007,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07653	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_2813216_3	1125971.ASJB01000042_gene3418	3.086e-56	217.0	COG3629@1|root,COG3629@2|Bacteria,2GKKQ@201174|Actinobacteria	201174|Actinobacteria	K	DNA-binding transcriptional activator of the SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
TLS2_k127_2813216_1	1385518.N798_09360	1.069e-236	793.0	COG2319@1|root,COG3629@1|root,COG2319@2|Bacteria,COG3629@2|Bacteria,2I3CQ@201174|Actinobacteria,4FK1F@85021|Intrasporangiaceae	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
TLS2_k127_2845396_3	1048339.KB913029_gene3505	5.361e-50	189.0	COG0347@1|root,COG0347@2|Bacteria,2IKN1@201174|Actinobacteria,4ESRI@85013|Frankiales	201174|Actinobacteria	K	Belongs to the P(II) protein family	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
TLS2_k127_2845396_0	743718.Isova_1181	5.066e-211	664.0	COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,4F3NT@85017|Promicromonosporaceae	201174|Actinobacteria	P	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TLS2_k127_2845396_1	1463856.JOHY01000025_gene3860	4.002e-154	497.0	COG0552@1|root,COG0552@2|Bacteria,2GJQH@201174|Actinobacteria	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
TLS2_k127_2845396_2	67281.JNZZ01000014_gene1714	7.729e-67	236.0	COG4987@1|root,COG4988@1|root,COG4987@2|Bacteria,COG4988@2|Bacteria,2I2DP@201174|Actinobacteria,418F4@629295|Streptomyces griseus group	201174|Actinobacteria	V	ABC transporter transmembrane region	cydD	-	-	ko:K16013,ko:K16014	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.129	-	-	ABC_membrane,ABC_tran
TLS2_k127_2859418_3	1120950.KB892744_gene2774	5.023e-153	493.0	COG1175@1|root,COG1175@2|Bacteria,2GKYS@201174|Actinobacteria,4DP26@85009|Propionibacteriales	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10233	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
TLS2_k127_2859418_4	1095767.CAHD01000073_gene290	4.301e-146	488.0	COG0395@1|root,COG0395@2|Bacteria,2GJNN@201174|Actinobacteria,4F0UW@85016|Cellulomonadaceae	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10234	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
TLS2_k127_2859418_2	196162.Noca_3917	4.204e-171	550.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria,4DSZX@85009|Propionibacteriales	201174|Actinobacteria	G	Glycosyl hydrolase family 1	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
TLS2_k127_2859418_0	1120950.KB892771_gene1297	1.591e-255	802.0	COG0526@1|root,COG0526@2|Bacteria,2GKDT@201174|Actinobacteria,4DPGX@85009|Propionibacteriales	201174|Actinobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,NHL,Thioredoxin_8
TLS2_k127_2859418_5	1449346.JQMO01000003_gene2487	3.654e-55	198.0	COG2050@1|root,COG2050@2|Bacteria,2IHSR@201174|Actinobacteria,2M3AB@2063|Kitasatospora	201174|Actinobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_2859418_6	1121272.KB903283_gene4892	1.491e-18	88.0	2DRBI@1|root,33B4D@2|Bacteria,2GWXK@201174|Actinobacteria,4DG4Y@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2859418_1	1120950.KB892771_gene1286	8.455e-231	722.0	COG1960@1|root,COG1960@2|Bacteria,2GJIB@201174|Actinobacteria,4DP6T@85009|Propionibacteriales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase N terminal	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,AcylCoA_DH_N
TLS2_k127_2862732_9	1386089.N865_21175	1.113e-60	214.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4FETI@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_2862732_11	1121946.AUAX01000008_gene7153	1.742e-14	86.0	COG1277@1|root,COG1277@2|Bacteria,2IMF1@201174|Actinobacteria,4DJ6A@85008|Micromonosporales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS2_k127_2862732_7	935866.JAER01000050_gene879	9.347e-99	346.0	COG1295@1|root,COG1295@2|Bacteria,2GM6P@201174|Actinobacteria,4DN9S@85009|Propionibacteriales	201174|Actinobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_2862732_5	471853.Bcav_0211	1.033e-135	437.0	COG1012@1|root,COG1012@2|Bacteria,2GKSN@201174|Actinobacteria	201174|Actinobacteria	C	Aldehyde dehydrogenase	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_2862732_1	471853.Bcav_0209	7.278e-267	827.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_2862732_4	110319.CF8_3048	6.565e-153	498.0	COG0274@1|root,COG0274@2|Bacteria,2GJIR@201174|Actinobacteria,4DNUJ@85009|Propionibacteriales	201174|Actinobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS2_k127_2862732_2	68260.JOAY01000018_gene3279	4.307e-223	704.0	COG1109@1|root,COG1109@2|Bacteria,2GJ3Q@201174|Actinobacteria	201174|Actinobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain II	pmmB	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_2862732_6	196162.Noca_3521	7.913e-125	404.0	COG0005@1|root,COG0005@2|Bacteria,2GKEI@201174|Actinobacteria,4DMXP@85009|Propionibacteriales	201174|Actinobacteria	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_2862732_8	28042.GU90_00250	1.791e-65	247.0	COG3703@1|root,COG3703@2|Bacteria,2GJM9@201174|Actinobacteria,4E2N8@85010|Pseudonocardiales	201174|Actinobacteria	P	AIG2-like family	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2
TLS2_k127_2862732_3	1120950.KB892785_gene237	3.55e-204	654.0	COG1249@1|root,COG1249@2|Bacteria,2GMP7@201174|Actinobacteria,4DNPF@85009|Propionibacteriales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044419,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051704,GO:0055114,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_2862732_10	44060.JODL01000004_gene2450	9.302e-48	188.0	2A4ZY@1|root,30TN1@2|Bacteria,2GMC5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2862732_0	1906.SFRA_15270	2.828e-291	903.0	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria	201174|Actinobacteria	I	carboxylase	bccA	-	6.3.4.14,6.4.1.2,6.4.1.3	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
TLS2_k127_2876967_1	1123321.KB905816_gene2860	2.33e-31	131.0	COG1309@1|root,COG1309@2|Bacteria,2IMN5@201174|Actinobacteria	201174|Actinobacteria	K	TetR Family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TLS2_k127_2876967_0	1081644.IMCC13023_02170	4.635e-175	575.0	COG1033@1|root,COG2409@1|root,COG1033@2|Bacteria,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4FRW2@85023|Microbacteriaceae	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994,ko:K20470	-	-	-	-	ko00000,ko02000	2.A.6.5.6	-	-	MMPL
TLS2_k127_2878525_9	1380390.JIAT01000009_gene917	3.619e-124	411.0	COG2208@1|root,COG2208@2|Bacteria,2GNG4@201174|Actinobacteria,4CQ08@84995|Rubrobacteria	84995|Rubrobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,TetR_N
TLS2_k127_2878525_6	1146883.BLASA_3760	3.824e-144	476.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,2GJB4@201174|Actinobacteria	201174|Actinobacteria	CE	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
TLS2_k127_2878525_13	247156.NFA_23440	7.917e-72	246.0	COG5592@1|root,COG5592@2|Bacteria,2IGW0@201174|Actinobacteria,4G0VV@85025|Nocardiaceae	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS2_k127_2878525_18	1386089.N865_15015	5.588e-07	59.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS2_k127_2878525_0	1380393.JHVP01000015_gene4196	5.697e-275	854.0	COG2192@1|root,COG2192@2|Bacteria,2GJHV@201174|Actinobacteria,4ETXX@85013|Frankiales	201174|Actinobacteria	O	Evidence 2b Function of strongly homologous gene	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TLS2_k127_2878525_1	477641.MODMU_0523	4.889e-213	682.0	COG0241@1|root,COG1216@1|root,COG0241@2|Bacteria,COG1216@2|Bacteria,2GK77@201174|Actinobacteria,4EVNN@85013|Frankiales	201174|Actinobacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	gmhB	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Hydrolase_like
TLS2_k127_2878525_8	1211815.CBYP010000030_gene1293	8.307e-131	432.0	COG0859@1|root,COG0859@2|Bacteria,2GSTW@201174|Actinobacteria	201174|Actinobacteria	M	PFAM glycosyl transferase family 9	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,Hydrolase_like
TLS2_k127_2878525_3	526225.Gobs_0458	5.703e-149	493.0	COG0438@1|root,COG0438@2|Bacteria,2GJUN@201174|Actinobacteria,4ETW7@85013|Frankiales	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
TLS2_k127_2878525_5	591158.SSMG_03105	5.453e-146	483.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway	-	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_2878525_12	408672.NBCG_04114	1.657e-73	270.0	COG0279@1|root,COG0279@2|Bacteria,2IIGW@201174|Actinobacteria,4DWTY@85009|Propionibacteriales	201174|Actinobacteria	G	SIS domain	gmhA	-	2.7.7.71,5.3.1.28	ko:K03271,ko:K15669	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769,R09772	RC00002,RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
TLS2_k127_2878525_4	1380356.JNIK01000011_gene1996	8.012e-148	490.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,2GKU1@201174|Actinobacteria,4ETXU@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
TLS2_k127_2878525_11	28042.GU90_02820	5.4e-87	314.0	COG4221@1|root,COG4221@2|Bacteria,2HZEI@201174|Actinobacteria,4DXAX@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_2878525_10	1380347.JNII01000006_gene1123	5.077e-93	334.0	COG0859@1|root,COG0859@2|Bacteria,2GMZG@201174|Actinobacteria,4EVAQ@85013|Frankiales	201174|Actinobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TLS2_k127_2878525_15	397278.JOJN01000003_gene2082	6.096e-40	171.0	COG3832@1|root,COG3832@2|Bacteria,2IKZ7@201174|Actinobacteria,4DRBJ@85009|Propionibacteriales	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_2878525_14	644283.Micau_2131	2.835e-71	271.0	COG0300@1|root,COG0300@2|Bacteria,2IGCX@201174|Actinobacteria,4D8SH@85008|Micromonosporales	201174|Actinobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_2878525_2	356851.JOAN01000011_gene5444	1.943e-188	595.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,4D9FD@85008|Micromonosporales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-associated	fdhA	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
TLS2_k127_2878525_7	1068980.ARVW01000001_gene6863	4.544e-131	438.0	COG2124@1|root,COG2124@2|Bacteria,2I9EA@201174|Actinobacteria,4E0TF@85010|Pseudonocardiales	201174|Actinobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_2878525_17	543632.JOJL01000025_gene2227	1.426e-22	98.0	2BB4Q@1|root,324M3@2|Bacteria,2H9HU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2878525_16	548477.HMPREF0294_1185	5.198e-27	111.0	COG2985@1|root,COG2985@2|Bacteria,2GKDW@201174|Actinobacteria,22KAK@1653|Corynebacteriaceae	201174|Actinobacteria	P	TrkA C-terminal domain protein	-	-	-	ko:K07085	-	-	-	-	ko00000	2.A.81	-	-	Asp-Al_Ex,TrkA_C
TLS2_k127_287910_2	330214.NIDE1201	8.671e-162	543.0	COG1249@1|root,COG1249@2|Bacteria,3J0IM@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	1.6.1.1,1.8.1.4	ko:K00322,ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map00760,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00112,R00209,R01221,R01698,R03815,R07618,R08549	RC00001,RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_287910_5	1064537.AGSO01000015_gene1003	6.959e-46	187.0	COG0526@1|root,COG0526@2|Bacteria,2IKP1@201174|Actinobacteria,4FCVC@85020|Dermabacteraceae	201174|Actinobacteria	O	Thioredoxin	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin
TLS2_k127_287910_3	1463901.JOIY01000025_gene482	8.504e-74	257.0	COG2220@1|root,COG2220@2|Bacteria,2GN98@201174|Actinobacteria	201174|Actinobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_287910_1	284031.JNXD01000030_gene2640	3.725e-170	551.0	COG2515@1|root,COG2515@2|Bacteria,2GIV5@201174|Actinobacteria	201174|Actinobacteria	E	1-aminocyclopropane-1-carboxylate deaminase	acdS	-	3.5.99.7,4.4.1.15	ko:K01505,ko:K05396	ko00270,map00270	-	R00997,R01874	RC00382,RC00419	ko00000,ko00001,ko01000	-	-	-	PALP
TLS2_k127_287910_4	1150864.MILUP08_46646	2.609e-72	254.0	COG1414@1|root,COG1414@2|Bacteria,2GMEA@201174|Actinobacteria,4D9ZT@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	sdrB	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR
TLS2_k127_287910_0	1157637.KB892102_gene1469	7.628e-235	746.0	COG0726@1|root,COG1215@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,2GJCE@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Polysacc_deac_1
TLS2_k127_2908640_2	512565.AMIS_17850	7.683e-136	439.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4D9U7@85008|Micromonosporales	201174|Actinobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
TLS2_k127_2908640_0	1380393.JHVP01000004_gene396	1.129e-232	748.0	COG4425@1|root,COG4425@2|Bacteria,2IBWT@201174|Actinobacteria,4ETTC@85013|Frankiales	201174|Actinobacteria	S	Alpha/beta-hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_9,Abhydrolase_9_N
TLS2_k127_2908640_5	1463895.JODA01000026_gene5401	1.067e-23	111.0	2E35Q@1|root,32Y5M@2|Bacteria,2GS2Q@201174|Actinobacteria	201174|Actinobacteria	S	Short C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT
TLS2_k127_2908640_4	935839.JAGJ01000005_gene2665	3.781e-59	209.0	2CXR2@1|root,32T2F@2|Bacteria,2I2M0@201174|Actinobacteria,4F5MY@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2908640_6	66373.JOFQ01000001_gene1477	2.16e-11	74.0	2EIST@1|root,33CI4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2908640_1	935839.JAGJ01000005_gene2668	7.1e-183	604.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
TLS2_k127_2908640_7	1140.Synpcc7942_2178	0.0004705	50.0	COG1950@1|root,COG1950@2|Bacteria,1G835@1117|Cyanobacteria,1H1UR@1129|Synechococcus	1117|Cyanobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
TLS2_k127_2908640_3	1440774.Y900_028070	3.346e-64	244.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,2387G@1762|Mycobacteriaceae	201174|Actinobacteria	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
TLS2_k127_2925461_2	935839.JAGJ01000005_gene2643	1.732e-23	111.0	COG0711@1|root,COG0711@2|Bacteria,2IQQZ@201174|Actinobacteria,4F5JF@85017|Promicromonosporaceae	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2925461_1	1068978.AMETH_0580	7.332e-33	135.0	2DMSR@1|root,32TF3@2|Bacteria,2IR08@201174|Actinobacteria,4E648@85010|Pseudonocardiales	201174|Actinobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
TLS2_k127_2925461_0	1150864.MILUP08_45651	7.484e-41	162.0	2B9CE@1|root,322Q4@2|Bacteria,2IKT2@201174|Actinobacteria,4DG4D@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3618)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3618
TLS2_k127_2973551_5	1079986.JH164843_gene6174	2.547e-20	98.0	COG1686@1|root,COG1686@2|Bacteria,2GK3M@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the peptidase S11 family	dac	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
TLS2_k127_2973551_1	1120950.KB892778_gene1035	1.905e-87	298.0	COG0596@1|root,COG0596@2|Bacteria,2GKT5@201174|Actinobacteria,4DP1Y@85009|Propionibacteriales	201174|Actinobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_2973551_0	1123024.AUII01000044_gene605	4.363e-136	439.0	COG3285@1|root,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria,4DZ9U@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA polymerase LigD polymerase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
TLS2_k127_2973551_8	935866.JAER01000001_gene2686	0.0009916	48.0	COG3214@1|root,COG3214@2|Bacteria,2GP6G@201174|Actinobacteria,4DPMS@85009|Propionibacteriales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
TLS2_k127_2973551_7	1463895.JODA01000058_gene5312	2.909e-06	51.0	COG1572@1|root,COG2931@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,2GKNI@201174|Actinobacteria	201174|Actinobacteria	Q	Domain of unknown function (DUF5122) beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF5122,HemolysinCabind
TLS2_k127_2973551_4	1306990.BARG01000052_gene6289	1.774e-26	120.0	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_2973551_2	1246474.ANBE01000014_gene2800	2.572e-71	247.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4EHS4@85012|Streptosporangiales	201174|Actinobacteria	T	COGs COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_2973551_3	1463864.JOGO01000003_gene1872	5.496e-48	187.0	COG4585@1|root,COG4585@2|Bacteria,2GKV2@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_2973551_6	1193181.BN10_140045	4.23e-19	102.0	COG1266@1|root,COG1266@2|Bacteria,2IGUR@201174|Actinobacteria,4FJ7Y@85021|Intrasporangiaceae	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS2_k127_2980337_1	1120950.KB892759_gene6223	7.854e-74	262.0	COG0424@1|root,COG0424@2|Bacteria,2GNI0@201174|Actinobacteria,4DQJD@85009|Propionibacteriales	201174|Actinobacteria	D	Maf-like protein	maf	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf,NUDIX
TLS2_k127_2980337_3	675635.Psed_5544	8.448e-56	211.0	COG1576@1|root,COG1576@2|Bacteria,2IGAN@201174|Actinobacteria,4E2Y6@85010|Pseudonocardiales	201174|Actinobacteria	J	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS2_k127_2980337_4	675635.Psed_5545	1.084e-38	149.0	COG3631@1|root,COG3631@2|Bacteria,2IQ9X@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS2_k127_2980337_2	570268.ANBB01000004_gene145	1.143e-56	200.0	COG0748@1|root,COG0748@2|Bacteria,2I3CW@201174|Actinobacteria,4EJ2B@85012|Streptosporangiales	201174|Actinobacteria	P	Pfam:DUF385	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS2_k127_2980337_0	1120950.KB892759_gene6228	4.741e-173	552.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4DPPG@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS2_k127_2985137_4	1120950.KB892775_gene1170	1.046e-41	166.0	2F62G@1|root,33YKU@2|Bacteria,2IHNY@201174|Actinobacteria,4DRHE@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2985137_2	1120950.KB892775_gene1171	1.256e-80	277.0	COG3142@1|root,COG3142@2|Bacteria,2GKI8@201174|Actinobacteria,4DQWU@85009|Propionibacteriales	201174|Actinobacteria	P	CutC family	cutC	-	-	ko:K06201	-	-	-	-	ko00000	-	-	-	CutC
TLS2_k127_2985137_5	1397278.AYMV01000007_gene219	5.391e-31	126.0	COG4339@1|root,COG4339@2|Bacteria,2IQ60@201174|Actinobacteria,4FPP4@85023|Microbacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4031)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4031
TLS2_k127_2985137_3	67352.JODS01000008_gene7135	3.849e-65	230.0	COG4339@1|root,COG4339@2|Bacteria,2GMYQ@201174|Actinobacteria	201174|Actinobacteria	L	nUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4031,HD
TLS2_k127_2985137_1	1283287.KB822583_gene2853	1.238e-105	364.0	COG0477@1|root,COG2814@2|Bacteria,2GMHP@201174|Actinobacteria,4DNQ2@85009|Propionibacteriales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_2985137_0	405948.SACE_6656	7.848e-125	406.0	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria,4E29D@85010|Pseudonocardiales	201174|Actinobacteria	E	Peptidase dimerisation domain	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_301034_6	1150864.MILUP08_41144	2.326e-45	172.0	COG3371@1|root,COG3371@2|Bacteria,2II34@201174|Actinobacteria,4DEDX@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
TLS2_k127_301034_2	1343740.M271_34195	7.955e-125	413.0	COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria	201174|Actinobacteria	GL	phosphoglycerate mutase	-	-	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
TLS2_k127_301034_3	1123322.KB904687_gene4978	7.802e-68	252.0	COG1579@1|root,COG1579@2|Bacteria,2GP84@201174|Actinobacteria	201174|Actinobacteria	S	Zn-ribbon protein, possibly nucleic acid-binding	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
TLS2_k127_301034_0	1048339.KB913029_gene4732	2.406e-144	469.0	COG0327@1|root,COG0327@2|Bacteria,2GKHZ@201174|Actinobacteria,4ES0X@85013|Frankiales	201174|Actinobacteria	S	NIF3 (NGG1p interacting factor 3)	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
TLS2_k127_301034_1	1120949.KB903294_gene4404	9.715e-140	462.0	COG2304@1|root,COG2304@2|Bacteria,2H3JW@201174|Actinobacteria,4DHZC@85008|Micromonosporales	201174|Actinobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_301034_7	1137269.AZWL01000025_gene80	2.899e-41	160.0	COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria	201174|Actinobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	ahpE	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
TLS2_k127_301034_5	1120950.KB892768_gene5259	1.483e-50	185.0	2B57P@1|root,31Y1M@2|Bacteria,2IFRB@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3052)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3052
TLS2_k127_301034_4	1463921.JODF01000003_gene2195	1.813e-61	214.0	COG0432@1|root,COG0432@2|Bacteria,2IHWS@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Uncharacterised protein family UPF0047	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	UPF0047
TLS2_k127_301034_8	1127134.NOCYR_0292	3.533e-23	102.0	2DQX7@1|root,3395Y@2|Bacteria,2I3TT@201174|Actinobacteria,4G9TT@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF1918)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1918
TLS2_k127_301034_9	1035308.AQYY01000001_gene3191	0.0009671	50.0	COG2609@1|root,COG2609@2|Bacteria	2|Bacteria	C	pyruvate dehydrogenase (acetyl-transferring) activity	aceE	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0004739,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016624,GO:0016903,GO:0030312,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046872,GO:0055114,GO:0071944,GO:1902494,GO:1990204	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS2_k127_3031857_6	1380356.JNIK01000021_gene4510	9.75e-12	75.0	COG0515@1|root,COG0515@2|Bacteria,2ID99@201174|Actinobacteria,4EV2G@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS2_k127_3031857_4	685727.REQ_11470	7.326e-42	155.0	COG0640@1|root,COG0640@2|Bacteria,2GNW2@201174|Actinobacteria,4G39U@85025|Nocardiaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_3031857_3	1265310.CCBD010000015_gene3601	4.336e-61	213.0	COG0346@1|root,COG0640@1|root,COG0346@2|Bacteria,COG0640@2|Bacteria,2IHQQ@201174|Actinobacteria,239IG@1762|Mycobacteriaceae	201174|Actinobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_3031857_2	105420.BBPO01000076_gene4643	2.074e-90	309.0	COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria,2NG6D@228398|Streptacidiphilus	201174|Actinobacteria	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
TLS2_k127_3031857_1	1033730.CAHG01000016_gene382	1.574e-199	667.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4DNH6@85009|Propionibacteriales	201174|Actinobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_3031857_0	196162.Noca_2304	7.472e-220	696.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4DN01@85009|Propionibacteriales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_3031857_5	1121926.AXWO01000025_gene3831	4.762e-18	87.0	2E6TR@1|root,331DK@2|Bacteria,2IQF8@201174|Actinobacteria,4F035@85014|Glycomycetales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3043370_6	526225.Gobs_0631	0.0005555	44.0	COG5495@1|root,COG5495@2|Bacteria,2I2F6@201174|Actinobacteria,4ERJ1@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF2520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
TLS2_k127_3043370_4	1380370.JIBA01000004_gene2346	2.373e-24	113.0	2DG7N@1|root,2ZUUC@2|Bacteria,2HXHE@201174|Actinobacteria,4FGW2@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3043370_2	1120950.KB892801_gene1730	4.65e-106	356.0	COG1565@1|root,COG1565@2|Bacteria,2GKIU@201174|Actinobacteria,4DTE5@85009|Propionibacteriales	201174|Actinobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
TLS2_k127_3043370_1	1120950.KB892801_gene1729	8.23e-126	427.0	COG3428@1|root,COG3428@2|Bacteria,2GJCD@201174|Actinobacteria,4DQ4J@85009|Propionibacteriales	201174|Actinobacteria	S	overlaps another CDS with the same product name	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
TLS2_k127_3043370_3	1120950.KB892801_gene1727	2.386e-53	196.0	COG3402@1|root,COG3402@2|Bacteria,2IR88@201174|Actinobacteria,4DRVV@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
TLS2_k127_3043370_0	1120950.KB892801_gene1726	1.814e-209	660.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4DSY9@85009|Propionibacteriales	201174|Actinobacteria	C	Belongs to the complex I 49 kDa subunit family	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS2_k127_3043370_5	1713.JOFV01000001_gene1812	1.798e-15	76.0	COG3358@1|root,COG3358@2|Bacteria,2GP66@201174|Actinobacteria,4F2FB@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
TLS2_k127_304505_4	1123024.AUII01000006_gene4590	1.487e-62	219.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4DXFH@85010|Pseudonocardiales	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0375c	CO_deh_flav_C,FAD_binding_5
TLS2_k127_304505_3	1429046.RR21198_2619	5.547e-81	273.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria,4FZ9X@85025|Nocardiaceae	201174|Actinobacteria	C	[2Fe-2S] binding domain	coxS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0374c	Fer2,Fer2_2
TLS2_k127_304505_0	882082.SaccyDRAFT_0611	0.0	1364.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4E1RG@85010|Pseudonocardiales	201174|Actinobacteria	C	TIGRFAM Carbon-monoxide dehydrogenase, large subunit	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_304505_1	675635.Psed_2659	1.217e-88	304.0	COG1975@1|root,COG3350@1|root,COG1975@2|Bacteria,COG3350@2|Bacteria,2IA9U@201174|Actinobacteria,4DXW1@85010|Pseudonocardiales	201174|Actinobacteria	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
TLS2_k127_304505_2	469383.Cwoe_3030	1.138e-82	295.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4CQYG@84995|Rubrobacteria	84995|Rubrobacteria	S	PFAM ATPase associated with various cellular activities, AAA_5	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
TLS2_k127_309827_13	1120949.KB903317_gene1643	4.872e-05	46.0	COG2133@1|root,COG3291@1|root,COG3506@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG3506@2|Bacteria,2HEMB@201174|Actinobacteria,4DA70@85008|Micromonosporales	201174|Actinobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,PA14,PKD
TLS2_k127_309827_8	1452536.JARE01000004_gene636	9.872e-37	152.0	COG0216@1|root,COG0216@2|Bacteria,2I7Z4@201174|Actinobacteria,4FPEN@85023|Microbacteriaceae	201174|Actinobacteria	J	RF-1 domain	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
TLS2_k127_309827_5	477641.MODMU_5235	1.23e-60	213.0	COG5637@1|root,COG5637@2|Bacteria,2GMK7@201174|Actinobacteria,4ESUI@85013|Frankiales	201174|Actinobacteria	S	Cyclase dehydrase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TLS2_k127_309827_1	67332.FM21_04660	2.472e-145	467.0	COG1064@1|root,COG1064@2|Bacteria,2GNNY@201174|Actinobacteria	201174|Actinobacteria	S	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_309827_11	1120950.KB892749_gene3352	2.044e-20	104.0	2E65S@1|root,330UF@2|Bacteria,2IMEQ@201174|Actinobacteria,4DSE6@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF3817)	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF3817
TLS2_k127_309827_7	28444.JODQ01000002_gene4096	2.181e-38	153.0	COG3346@1|root,COG3346@2|Bacteria,2GMGB@201174|Actinobacteria,4EIV8@85012|Streptosporangiales	201174|Actinobacteria	S	SURF1 family	-	-	-	-	-	-	-	-	-	-	-	-	SURF1
TLS2_k127_309827_0	1306174.JODP01000009_gene6586	1.993e-207	659.0	COG1233@1|root,COG1233@2|Bacteria,2GJAV@201174|Actinobacteria	201174|Actinobacteria	Q	phytoene	crtI2	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
TLS2_k127_309827_3	1121385.AQXW01000003_gene561	1.344e-94	327.0	COG2232@1|root,COG2232@2|Bacteria,2IDDC@201174|Actinobacteria,1ZWHS@145357|Dermacoccaceae	201174|Actinobacteria	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_309827_2	2074.JNYD01000014_gene7073	2.258e-125	415.0	COG1215@1|root,COG1215@2|Bacteria,2GJZI@201174|Actinobacteria,4DZ72@85010|Pseudonocardiales	201174|Actinobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_transf_21,Glycos_transf_2
TLS2_k127_309827_4	526226.Gbro_2548	1.503e-67	244.0	COG2324@1|root,COG2324@2|Bacteria,2IIUJ@201174|Actinobacteria,4GC2C@85026|Gordoniaceae	201174|Actinobacteria	S	Carotenoid biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Caroten_synth
TLS2_k127_309827_6	1206730.BAGA01000102_gene6034	1.143e-52	192.0	28JRZ@1|root,2Z9HI@2|Bacteria,2H9EF@201174|Actinobacteria,4FVSI@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
TLS2_k127_309827_9	1112204.GPOL_c48210	2.434e-28	118.0	29UQ5@1|root,30G1W@2|Bacteria,2II02@201174|Actinobacteria,4GC09@85026|Gordoniaceae	201174|Actinobacteria	C	spheroidene monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_309827_10	395495.Lcho_3908	1.114e-21	102.0	2EHB6@1|root,33B31@2|Bacteria,1NJAV@1224|Proteobacteria,2VX1V@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_309827_12	713586.KB900536_gene2240	2.97e-07	59.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_3117484_3	351160.RCIX872	1.396e-44	177.0	COG2234@1|root,arCOG02959@2157|Archaea	2157|Archaea	S	Peptidase M28	ywaD2	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
TLS2_k127_3117484_0	1079986.JH164846_gene2017	2.341e-111	366.0	COG0702@1|root,COG0702@2|Bacteria,2GJB8@201174|Actinobacteria	201174|Actinobacteria	GM	PFAM NmrA family protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
TLS2_k127_3117484_2	390989.JOEG01000003_gene4686	1.216e-83	288.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4D9TH@85008|Micromonosporales	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_3117484_1	446466.Cfla_0716	3.12e-94	327.0	COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,4F0RX@85016|Cellulomonadaceae	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	phoR	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_3117484_4	266940.Krad_1320	7.697e-15	85.0	2EPZ4@1|root,33HJQ@2|Bacteria,2GYV7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3126707_3	561175.KB894093_gene3635	7.302e-28	116.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GMN4@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
TLS2_k127_3126707_4	1123322.KB904634_gene2433	1.204e-07	63.0	2FHIX@1|root,349CW@2|Bacteria,2GN7H@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3126707_1	1206732.BAGD01000277_gene6244	6.645e-125	431.0	COG3540@1|root,COG3540@2|Bacteria,2IMZY@201174|Actinobacteria	201174|Actinobacteria	P	PhoD-like phosphatase	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD
TLS2_k127_3126707_0	1120950.KB892757_gene6609	4.828e-167	535.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4DU7F@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_3126707_2	471853.Bcav_2210	1.226e-59	210.0	COG3795@1|root,COG3795@2|Bacteria,2IIV2@201174|Actinobacteria	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_3137641_12	1157637.KB892146_gene7023	1.068e-27	113.0	COG0111@1|root,COG0111@2|Bacteria,2GP09@201174|Actinobacteria	201174|Actinobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase	pdxB	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_3137641_17	644548.SCNU_01810	1.111e-06	59.0	COG3467@1|root,COG3467@2|Bacteria,2I2X2@201174|Actinobacteria,4GEQC@85026|Gordoniaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_3137641_9	1306174.JODP01000031_gene4004	3.918e-58	213.0	COG2138@1|root,COG2138@2|Bacteria,2GNJ0@201174|Actinobacteria	201174|Actinobacteria	I	cobalamin (vitamin B12) biosynthesis CbiX protein	sirB	-	-	-	-	-	-	-	-	-	-	-	CbiX
TLS2_k127_3137641_0	1429046.RR21198_5344	2.49e-309	953.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4FUF7@85025|Nocardiaceae	201174|Actinobacteria	E	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS2_k127_3137641_6	28444.JODQ01000015_gene1732	6.796e-138	471.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4EGMM@85012|Streptosporangiales	201174|Actinobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4
TLS2_k127_3137641_1	1120950.KB892741_gene2671	1.349e-308	956.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4DNJX@85009|Propionibacteriales	201174|Actinobacteria	E	Thiamine pyrophosphate enzyme, central domain	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_3137641_8	471852.Tcur_3553	8.698e-85	283.0	COG0440@1|root,COG0440@2|Bacteria,2GJCH@201174|Actinobacteria,4EFRV@85012|Streptosporangiales	201174|Actinobacteria	E	Small subunit of acetolactate synthase	ilvN	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
TLS2_k127_3137641_4	1120950.KB892741_gene2673	1.015e-188	601.0	COG0059@1|root,COG0059@2|Bacteria,2GKXA@201174|Actinobacteria,4DNFA@85009|Propionibacteriales	201174|Actinobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008677,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
TLS2_k127_3137641_2	1123320.KB889676_gene2915	1.212e-255	797.0	COG0111@1|root,COG0111@2|Bacteria,2GJGA@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
TLS2_k127_3137641_10	479431.Namu_3835	1.011e-45	177.0	COG1695@1|root,COG1695@2|Bacteria,2IFDN@201174|Actinobacteria,4ET5U@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_3137641_15	1968.JOEV01000008_gene7921	4.123e-12	74.0	COG4758@1|root,COG4758@2|Bacteria,2I8FE@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF1707)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF1707,DUF2154
TLS2_k127_3137641_14	926554.KI912664_gene1577	5.503e-17	91.0	29XYR@1|root,30JRD@2|Bacteria,1WNBY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Lysyl oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Lysyl_oxidase
TLS2_k127_3137641_16	469383.Cwoe_3559	4.9e-08	59.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,4CP5R@84995|Rubrobacteria	84995|Rubrobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS2_k127_3137641_5	471853.Bcav_1417	2.373e-180	570.0	COG0473@1|root,COG0473@2|Bacteria,2GK44@201174|Actinobacteria	201174|Actinobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_3137641_11	1380393.JHVP01000004_gene596	1.191e-31	137.0	COG3832@1|root,COG3832@2|Bacteria,2IBWM@201174|Actinobacteria,4EWJS@85013|Frankiales	201174|Actinobacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3137641_3	1380393.JHVP01000004_gene612	2.201e-202	648.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
TLS2_k127_3137641_7	1380347.JNII01000006_gene1903	2.35e-113	376.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4EV42@85013|Frankiales	201174|Actinobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS2_k127_3137641_13	1380393.JHVP01000004_gene608	3.443e-21	95.0	COG4977@1|root,COG4977@2|Bacteria,2I2KX@201174|Actinobacteria,4ESZP@85013|Frankiales	201174|Actinobacteria	K	DJ-1/PfpI family	thiJ	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
TLS2_k127_316697_7	1123024.AUII01000003_gene3440	1.982e-168	570.0	COG1165@1|root,COG1165@2|Bacteria,2GMEB@201174|Actinobacteria,4DYET@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
TLS2_k127_316697_17	593907.Celgi_0730	2.723e-117	388.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria,4F0IF@85016|Cellulomonadaceae	201174|Actinobacteria	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	GO:0008150,GO:0040007	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0553	MR_MLE_C
TLS2_k127_316697_10	1033736.CAHK01000037_gene2541	3.404e-161	519.0	COG0447@1|root,COG0447@2|Bacteria,2GK5G@201174|Actinobacteria,4F8F9@85019|Brevibacteriaceae	201174|Actinobacteria	H	Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_316697_23	1068978.AMETH_0470	2.484e-96	331.0	COG0318@1|root,COG0318@2|Bacteria,2GN9C@201174|Actinobacteria,4DYFK@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	menE	GO:0003674,GO:0003824,GO:0008150,GO:0008756,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0040007	4.2.1.113,6.2.1.26	ko:K01911,ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030,R04031	RC00004,RC00014,RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_316697_22	479435.Kfla_6313	1.686e-96	334.0	COG1575@1|root,COG1575@2|Bacteria,2GJBS@201174|Actinobacteria,4DNAI@85009|Propionibacteriales	201174|Actinobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	GO:0003674,GO:0003824,GO:0004659,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TLS2_k127_316697_32	1045009.AFXQ01000022_gene1131	1.073e-34	147.0	COG3153@1|root,COG3153@2|Bacteria,2IKX0@201174|Actinobacteria,1W9SX@1268|Micrococcaceae	201174|Actinobacteria	S	Acetyltransferase (GNAT) family	-	-	-	ko:K03824,ko:K09964	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_9,Methyltransf_11,Methyltransf_25
TLS2_k127_316697_15	356851.JOAN01000011_gene5380	1.275e-134	443.0	COG0025@1|root,COG0025@2|Bacteria,2GKCK@201174|Actinobacteria,4DAWY@85008|Micromonosporales	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS2_k127_316697_39	1236902.ANAS01000019_gene4149	5.807e-11	70.0	2DZ3S@1|root,34CBX@2|Bacteria,2GX0A@201174|Actinobacteria,4EKZ4@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF4229)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4229
TLS2_k127_316697_19	1120950.KB892801_gene1794	9.066e-104	352.0	COG1171@1|root,COG1171@2|Bacteria,2I8UC@201174|Actinobacteria,4DR0H@85009|Propionibacteriales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_316697_36	1134445.AJJM01000064_gene1806	3.837e-25	109.0	2EGDD@1|root,33A58@2|Bacteria,2GR3X@201174|Actinobacteria	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
TLS2_k127_316697_41	1267534.KB906755_gene4016	6.128e-05	51.0	COG0346@1|root,COG0346@2|Bacteria,3Y5XY@57723|Acidobacteria,2JNPD@204432|Acidobacteriia	204432|Acidobacteriia	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_316697_26	1048339.KB913029_gene2342	5.303e-90	308.0	COG0755@1|root,COG0755@2|Bacteria,2GJR1@201174|Actinobacteria,4ESE9@85013|Frankiales	201174|Actinobacteria	O	Cytochrome c-type biogenesis protein	ccsB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
TLS2_k127_316697_6	1120950.KB892801_gene1786	2.426e-171	568.0	COG1333@1|root,COG1333@2|Bacteria,2GMGH@201174|Actinobacteria,4DN12@85009|Propionibacteriales	201174|Actinobacteria	O	ResB-like family	resB	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
TLS2_k127_316697_24	68219.JNXI01000032_gene7012	1.604e-95	333.0	COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria	201174|Actinobacteria	O	Cytochrome c biogenesis protein	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
TLS2_k127_316697_30	1120950.KB892801_gene1784	1.053e-50	192.0	COG0526@1|root,COG0526@2|Bacteria,2GP7J@201174|Actinobacteria,4DRF7@85009|Propionibacteriales	201174|Actinobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_316697_25	1157637.KB892096_gene934	4.545e-91	313.0	COG0406@1|root,COG0406@2|Bacteria,2GMXF@201174|Actinobacteria	201174|Actinobacteria	G	phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
TLS2_k127_316697_2	68570.DC74_3941	2.256e-191	617.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria	201174|Actinobacteria	H	Aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_316697_38	479432.Sros_6711	1.096e-15	81.0	2DRYF@1|root,33DPE@2|Bacteria,2I0A5@201174|Actinobacteria,4EPXF@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_316697_4	37919.EP51_03050	7.483e-172	557.0	2CA5R@1|root,2Z81H@2|Bacteria,2GM6V@201174|Actinobacteria,4FVE9@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_316697_29	1122933.JNIY01000003_gene51	9.727e-51	182.0	COG1695@1|root,COG1695@2|Bacteria,2IQSE@201174|Actinobacteria,4F1CD@85016|Cellulomonadaceae	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	ywzG	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_316697_31	526225.Gobs_2161	3.417e-42	158.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
TLS2_k127_316697_27	1206744.BAGL01000085_gene2852	8.533e-56	202.0	COG1742@1|root,COG1742@2|Bacteria,2IKM8@201174|Actinobacteria,4G23W@85025|Nocardiaceae	201174|Actinobacteria	S	Uncharacterised BCR, YnfA/UPF0060 family	-	GO:0005575,GO:0005576	-	ko:K09771	-	-	-	-	ko00000,ko02000	2.A.7.26	-	-	UPF0060
TLS2_k127_316697_9	935839.JAGJ01000034_gene2191	1.537e-166	546.0	COG1506@1|root,COG3247@1|root,COG1506@2|Bacteria,COG3247@2|Bacteria,2I46B@201174|Actinobacteria	201174|Actinobacteria	E	Secretory lipase	-	-	-	-	-	-	-	-	-	-	-	-	DUF308,LIP
TLS2_k127_316697_28	1068980.ARVW01000001_gene7482	3.797e-53	189.0	COG3795@1|root,COG3795@2|Bacteria,2IKRD@201174|Actinobacteria,4E51J@85010|Pseudonocardiales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_316697_1	1160718.SU9_27504	7.714e-206	646.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_316697_35	2074.JNYD01000012_gene391	2.675e-26	119.0	COG3509@1|root,COG3509@2|Bacteria,2GNV6@201174|Actinobacteria,4EEDH@85010|Pseudonocardiales	201174|Actinobacteria	Q	Esterase PHB depolymerase	lpqP	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase_phd
TLS2_k127_316697_13	369723.Strop_0359	2.109e-147	473.0	COG0113@1|root,COG0113@2|Bacteria,2GJJ0@201174|Actinobacteria,4D999@85008|Micromonosporales	201174|Actinobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
TLS2_k127_316697_8	110319.CF8_1545	3.446e-168	551.0	COG1404@1|root,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria,4DNZ1@85009|Propionibacteriales	201174|Actinobacteria	O	Peptidase inhibitor I9	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,Peptidase_S8
TLS2_k127_316697_0	1298863.AUEP01000019_gene3551	5.523e-222	712.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2GMJZ@201174|Actinobacteria,4DNP0@85009|Propionibacteriales	201174|Actinobacteria	H	Uroporphyrinogen-III synthase HemD	hemD	-	2.1.1.107,4.2.1.75	ko:K01719,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
TLS2_k127_316697_21	585531.HMPREF0063_12612	5.397e-101	359.0	COG0181@1|root,COG0181@2|Bacteria,2GMWI@201174|Actinobacteria,4DN1M@85009|Propionibacteriales	201174|Actinobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0510	Porphobil_deam,Porphobil_deamC
TLS2_k127_316697_14	1449346.JQMO01000003_gene5015	6.145e-143	475.0	COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,2M20A@2063|Kitasatospora	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0008150,GO:0040007	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
TLS2_k127_316697_20	110319.CF8_0421	1.612e-101	336.0	COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria,4DPX5@85009|Propionibacteriales	201174|Actinobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
TLS2_k127_316697_33	1172188.KB911826_gene47	7.599e-34	138.0	COG0695@1|root,COG0695@2|Bacteria,2IR0P@201174|Actinobacteria,4FHMF@85021|Intrasporangiaceae	201174|Actinobacteria	O	Glutaredoxin-like domain (DUF836)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF836
TLS2_k127_316697_11	479435.Kfla_6379	6.12e-152	501.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DN25@85009|Propionibacteriales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_316697_37	479432.Sros_2146	1.608e-21	104.0	COG0596@1|root,COG0596@2|Bacteria,2GU04@201174|Actinobacteria,4EPP1@85012|Streptosporangiales	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_316697_18	110319.CF8_0418	9.059e-109	363.0	COG0560@1|root,COG0560@2|Bacteria,2GJW9@201174|Actinobacteria,4DNKX@85009|Propionibacteriales	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	serB1	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HAD
TLS2_k127_316697_16	710696.Intca_0651	8.658e-134	445.0	COG0204@1|root,COG0204@2|Bacteria,2GJKH@201174|Actinobacteria,4FG6Z@85021|Intrasporangiaceae	201174|Actinobacteria	I	Phosphate acyltransferases	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TLS2_k127_316697_12	1120950.KB892801_gene1769	2.004e-147	474.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria,4DPEE@85009|Propionibacteriales	201174|Actinobacteria	GM	GDP-mannose 4,6 dehydratase	galE2	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0501	Epimerase
TLS2_k127_316697_40	1110697.NCAST_20_02705	2.484e-09	59.0	2DEN5@1|root,2ZNJ2@2|Bacteria,2GWJ8@201174|Actinobacteria,4G4RE@85025|Nocardiaceae	201174|Actinobacteria	S	Mitochondrial domain of unknown function (DUF1713)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1713
TLS2_k127_316697_34	479432.Sros_0537	9.198e-27	112.0	COG3311@1|root,COG3311@2|Bacteria,2GQGV@201174|Actinobacteria,4EKJX@85012|Streptosporangiales	201174|Actinobacteria	K	Helix-turn-helix domain	xis	-	-	-	-	-	-	-	-	-	-	-	HTH_17
TLS2_k127_316697_5	1122138.AQUZ01000014_gene7079	8.028e-172	546.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4DN6Q@85009|Propionibacteriales	201174|Actinobacteria	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
TLS2_k127_316697_3	1380356.JNIK01000017_gene2991	5.024e-172	551.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4ES4U@85013|Frankiales	201174|Actinobacteria	L	DEAD DEAH box helicase domain protein	rhlE1	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
TLS2_k127_318984_1	110319.CF8_0182	1.612e-92	308.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4DN4V@85009|Propionibacteriales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	ugpC	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
TLS2_k127_318984_0	471853.Bcav_0782	7.556e-180	574.0	COG3642@1|root,COG3642@2|Bacteria,2GIX0@201174|Actinobacteria	201174|Actinobacteria	T	Domain of unknown function (DUF4032)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032,Kdo
TLS2_k127_318984_2	1429046.RR21198_0593	3.33e-49	189.0	COG5340@1|root,COG5340@2|Bacteria,2II40@201174|Actinobacteria,4G06Z@85025|Nocardiaceae	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4
TLS2_k127_3240024_6	469371.Tbis_1309	2.025e-09	60.0	COG3568@1|root,COG3568@2|Bacteria,2GMRU@201174|Actinobacteria	201174|Actinobacteria	S	endonuclease exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_3240024_1	1172188.KB911822_gene753	5.193e-134	436.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4FHT0@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_3240024_7	246196.MSMEI_1280	2.854e-08	62.0	COG1802@1|root,COG1802@2|Bacteria,2I9WQ@201174|Actinobacteria,23B3F@1762|Mycobacteriaceae	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_3240024_3	1032480.MLP_33760	3.661e-43	174.0	COG3832@1|root,COG3832@2|Bacteria,2I4FM@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_3240024_0	1122138.AQUZ01000087_gene1188	1.57e-285	897.0	COG3291@1|root,COG4870@1|root,COG3291@2|Bacteria,COG4870@2|Bacteria,2GKA0@201174|Actinobacteria	201174|Actinobacteria	O	Pregnancy-associated plasma protein-A	-	-	-	-	-	-	-	-	-	-	-	-	DUF346,Peptidase_M43
TLS2_k127_3240024_4	37919.EP51_14075	3.314e-31	126.0	COG3291@1|root,COG3291@2|Bacteria,2GKA0@201174|Actinobacteria,4FZAR@85025|Nocardiaceae	201174|Actinobacteria	S	Pregnancy-associated plasma protein-A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M43
TLS2_k127_3240024_2	1122138.AQUZ01000087_gene1186	4.203e-107	364.0	COG2234@1|root,COG2234@2|Bacteria,2GIT0@201174|Actinobacteria,4DQCH@85009|Propionibacteriales	201174|Actinobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_3240024_5	1146883.BLASA_1383	5.385e-24	104.0	COG2337@1|root,COG2337@2|Bacteria,2IR5D@201174|Actinobacteria	201174|Actinobacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
TLS2_k127_3267548_0	1157637.KB892122_gene465	1.564e-214	670.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_3267548_3	479435.Kfla_1782	9.781e-64	225.0	COG4636@1|root,COG4636@2|Bacteria,2IGTR@201174|Actinobacteria,4DRGB@85009|Propionibacteriales	201174|Actinobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS2_k127_3267548_1	1157637.KB892122_gene464	3.67e-156	506.0	COG3004@1|root,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria	201174|Actinobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
TLS2_k127_3267548_4	1120950.KB892762_gene5481	7.574e-36	140.0	2DPPE@1|root,332VJ@2|Bacteria,2IN30@201174|Actinobacteria,4DSE1@85009|Propionibacteriales	201174|Actinobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
TLS2_k127_3267548_2	1120950.KB892762_gene5482	2.271e-136	445.0	COG2267@1|root,COG2267@2|Bacteria,2I2IM@201174|Actinobacteria,4DQ6A@85009|Propionibacteriales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_3273753_0	1240349.ANGC01000009_gene2798	1.259e-170	550.0	COG0596@1|root,COG0596@2|Bacteria,2GKX3@201174|Actinobacteria,4FZTX@85025|Nocardiaceae	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3273753_1	323261.Noc_1451	5.873e-152	493.0	28J3E@1|root,2Z8ZN@2|Bacteria,1R4DZ@1224|Proteobacteria,1S1XI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3273753_13	266117.Rxyl_2437	1.171e-35	150.0	COG1073@1|root,COG1073@2|Bacteria,2I2KN@201174|Actinobacteria	201174|Actinobacteria	S	alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
TLS2_k127_3273753_5	306281.AJLK01000131_gene1437	9.85e-84	290.0	COG0300@1|root,COG0300@2|Bacteria,1G7GB@1117|Cyanobacteria	1117|Cyanobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_3273753_2	1048339.KB913029_gene3456	9.893e-139	466.0	COG1948@1|root,COG4880@2|Bacteria,2I8JU@201174|Actinobacteria	201174|Actinobacteria	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
TLS2_k127_3273753_12	1472418.BBJC01000002_gene1116	9.84e-36	151.0	COG0558@1|root,COG0558@2|Bacteria,1N1AE@1224|Proteobacteria,2UCWB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
TLS2_k127_3273753_3	58123.JOFJ01000005_gene1383	5.571e-127	429.0	COG1063@1|root,COG1063@2|Bacteria,2GKU2@201174|Actinobacteria,4EMX3@85012|Streptosporangiales	201174|Actinobacteria	E	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH_N
TLS2_k127_3273753_14	1232429.CBLL010000063_gene555	2.604e-21	98.0	COG0720@1|root,COG0720@2|Bacteria,2II5D@201174|Actinobacteria,1W9UP@1268|Micrococcaceae	201174|Actinobacteria	H	6-pyruvoyl tetrahydropterin synthase	ptpS	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
TLS2_k127_3273753_4	1157637.KB892111_gene4234	1.965e-85	295.0	COG0438@1|root,COG0438@2|Bacteria,2GYA2@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_3273753_9	58123.JOFJ01000005_gene1380	4.279e-59	216.0	COG2263@1|root,COG2263@2|Bacteria,2GNKR@201174|Actinobacteria	201174|Actinobacteria	J	DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_3273753_6	1206101.AZXC01000027_gene5557	1.079e-75	273.0	COG1985@1|root,COG1985@2|Bacteria,2IDQF@201174|Actinobacteria	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_3273753_11	479435.Kfla_3734	5.584e-39	156.0	29QBK@1|root,30BAT@2|Bacteria,2IH7J@201174|Actinobacteria,4DS01@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3273753_10	1292020.H483_0105335	4.833e-53	193.0	COG3304@1|root,COG3304@2|Bacteria,2IKS5@201174|Actinobacteria	201174|Actinobacteria	S	membrane	yccF	-	-	-	-	-	-	-	-	-	-	-	YccF
TLS2_k127_3273753_7	1033730.CAHG01000005_gene948	2.801e-72	247.0	COG0346@1|root,COG0346@2|Bacteria,2I5X0@201174|Actinobacteria,4DWZX@85009|Propionibacteriales	201174|Actinobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
TLS2_k127_3302795_9	1397278.AYMV01000007_gene347	1.134e-14	74.0	COG0333@1|root,COG0333@2|Bacteria,2HSQ4@201174|Actinobacteria,4FPTP@85023|Microbacteriaceae	201174|Actinobacteria	J	structural constituent of ribosome	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
TLS2_k127_3302795_5	471852.Tcur_3433	2.166e-100	335.0	COG0571@1|root,COG0571@2|Bacteria,2GKER@201174|Actinobacteria,4EGGX@85012|Streptosporangiales	201174|Actinobacteria	K	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
TLS2_k127_3302795_4	1123024.AUII01000001_gene2764	4.216e-119	395.0	COG0266@1|root,COG0266@2|Bacteria,2GJNT@201174|Actinobacteria,4DXDQ@85010|Pseudonocardiales	201174|Actinobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034039,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_3302795_7	928724.SacglDRAFT_01033	7.658e-27	112.0	COG1254@1|root,COG1254@2|Bacteria,2IQ4M@201174|Actinobacteria,4E5XK@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the acylphosphatase family	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
TLS2_k127_3302795_8	1394178.AWOO02000025_gene4952	1.142e-16	83.0	2ENN7@1|root,33G9I@2|Bacteria,2IQG5@201174|Actinobacteria,4EKK4@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3302795_0	1120950.KB892741_gene2716	0.0	1368.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4DN2T@85009|Propionibacteriales	201174|Actinobacteria	D	Required for chromosome condensation and partitioning	smc	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
TLS2_k127_3302795_1	1122182.KB903836_gene5089	1.888e-217	683.0	COG1271@1|root,COG1271@2|Bacteria,2GJE4@201174|Actinobacteria,4DA5S@85008|Micromonosporales	201174|Actinobacteria	C	PFAM cytochrome bd ubiquinol oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
TLS2_k127_3302795_3	1122182.KB903836_gene5090	1.497e-152	490.0	COG1294@1|root,COG1294@2|Bacteria,2GMFV@201174|Actinobacteria,4DATV@85008|Micromonosporales	201174|Actinobacteria	C	cytochrome d ubiquinol oxidase, subunit	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
TLS2_k127_3302795_2	469371.Tbis_2748	1.69e-168	552.0	COG4988@1|root,COG4988@2|Bacteria,2I2DP@201174|Actinobacteria,4DY1E@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD	cydD	-	-	ko:K06148,ko:K16013,ko:K16014	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.129	-	-	ABC_membrane,ABC_tran
TLS2_k127_3302795_6	390989.JOEG01000006_gene855	2.878e-93	318.0	COG4987@1|root,COG4987@2|Bacteria,2H79B@201174|Actinobacteria,4DAZ1@85008|Micromonosporales	201174|Actinobacteria	CO	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC	cydC	-	-	ko:K16012	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.129	-	-	ABC_membrane,ABC_tran
TLS2_k127_330991_1	479435.Kfla_3107	8.533e-70	253.0	COG0237@1|root,COG0237@2|Bacteria,2GN96@201174|Actinobacteria,4DQNK@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE,GrpB
TLS2_k127_330991_0	882083.SacmaDRAFT_2660	6.848e-208	651.0	COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,2GIZP@201174|Actinobacteria,4DZJ9@85010|Pseudonocardiales	201174|Actinobacteria	I	Acetyl propionyl-CoA carboxylase, alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
TLS2_k127_3310298_3	1298863.AUEP01000008_gene1265	2.061e-108	358.0	COG0123@1|root,COG0123@2|Bacteria,2I8UK@201174|Actinobacteria,4DU14@85009|Propionibacteriales	201174|Actinobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TLS2_k127_3310298_0	479435.Kfla_5184	0.0	1745.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4DN7Q@85009|Propionibacteriales	201174|Actinobacteria	C	2-oxoglutarate dehydrogenase	kgd	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
TLS2_k127_3310298_10	1463934.JOCF01000017_gene4074	1.395e-26	109.0	2E460@1|root,32Z20@2|Bacteria,2GQGS@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3310298_7	266940.Krad_1227	3.95e-45	183.0	COG2755@1|root,COG2755@2|Bacteria,2IA8J@201174|Actinobacteria	201174|Actinobacteria	E	G-D-S-L family lipolytic protein	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS2_k127_3310298_2	1120950.KB892749_gene3298	5.754e-147	471.0	COG0604@1|root,COG0604@2|Bacteria,2GMHR@201174|Actinobacteria,4DN65@85009|Propionibacteriales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	adh3	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_3310298_1	326424.FRAAL5985	5.861e-170	544.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,4ERGN@85013|Frankiales	201174|Actinobacteria	C	PFAM malic	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
TLS2_k127_3310298_9	1306174.JODP01000018_gene4503	7.595e-27	126.0	COG0681@1|root,COG0681@2|Bacteria	2|Bacteria	U	signal peptide processing	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
TLS2_k127_3310298_5	1120950.KB892749_gene3304	4.322e-61	237.0	293MU@1|root,2ZR3M@2|Bacteria,2IFCB@201174|Actinobacteria,4DQX0@85009|Propionibacteriales	201174|Actinobacteria	S	Nickel-containing superoxide dismutase	sodN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.15.1.1	ko:K00518	-	-	-	-	ko00000,ko01000	-	-	-	Sod_Ni
TLS2_k127_3310298_6	269800.Tfu_0561	1.01e-55	200.0	COG0454@1|root,COG0456@2|Bacteria,2I2QV@201174|Actinobacteria,4EIYD@85012|Streptosporangiales	201174|Actinobacteria	K	FR47-like protein	ats	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_3310298_8	44060.JODL01000001_gene3156	2.332e-40	154.0	COG2172@1|root,COG2172@2|Bacteria,2IFG9@201174|Actinobacteria	201174|Actinobacteria	T	anti-sigma regulatory factor	rsbW	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036094,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
TLS2_k127_3310298_4	1463920.JOGB01000059_gene3935	9.085e-91	304.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	sigF	GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_3347766_2	1184607.AUCHE_05_00930	6.79e-126	417.0	COG0396@1|root,COG0396@2|Bacteria,2GKB7@201174|Actinobacteria,4F6M7@85018|Dermatophilaceae	201174|Actinobacteria	O	ATPases associated with a variety of cellular activities	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
TLS2_k127_3347766_3	1120950.KB892707_gene4652	4.116e-41	157.0	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,4DRMD@85009|Propionibacteriales	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	hcaC	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
TLS2_k127_3347766_1	1306174.JODP01000002_gene5922	7.147e-144	467.0	COG0719@1|root,COG0719@2|Bacteria,2GJNV@201174|Actinobacteria	201174|Actinobacteria	O	FeS assembly protein SufD	sufD	GO:0008150,GO:0009605,GO:0009607,GO:0040007,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
TLS2_k127_3347766_0	1121946.AUAX01000012_gene6508	1.62e-159	503.0	COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria,4D8I1@85008|Micromonosporales	201174|Actinobacteria	O	assembly protein sufB	sufB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TLS2_k127_3353468_0	471853.Bcav_1999	1.909e-176	559.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria	201174|Actinobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TLS2_k127_3353468_4	1122609.AUGT01000002_gene3953	1.156e-54	198.0	COG0503@1|root,COG0503@2|Bacteria,2IM7C@201174|Actinobacteria,4DQKV@85009|Propionibacteriales	201174|Actinobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
TLS2_k127_3353468_3	1120950.KB892708_gene4278	2.671e-104	356.0	COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria,4DPBJ@85009|Propionibacteriales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_3353468_2	1120950.KB892708_gene4277	2.652e-157	514.0	COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4DP94@85009|Propionibacteriales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_3353468_5	1120950.KB892708_gene4276	3.688e-23	102.0	COG1862@1|root,COG1862@2|Bacteria,2IQSP@201174|Actinobacteria	201174|Actinobacteria	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TLS2_k127_3353468_1	1003195.SCAT_5305	9.525e-163	520.0	COG2255@1|root,COG2255@2|Bacteria,2GJZF@201174|Actinobacteria	201174|Actinobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
TLS2_k127_338345_5	235985.BBPN01000005_gene2869	1.058e-18	87.0	COG1718@1|root,COG1718@2|Bacteria,2GKX1@201174|Actinobacteria,2NGH5@228398|Streptacidiphilus	201174|Actinobacteria	DT	Serine threonine protein kinase involved in cell cycle control	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_338345_4	500153.JOEK01000004_gene682	1.253e-38	151.0	2CP0Z@1|root,32SI8@2|Bacteria,2IHXV@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3037)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3037
TLS2_k127_338345_1	1123320.KB889688_gene425	2.834e-170	539.0	COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria	201174|Actinobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
TLS2_k127_338345_0	28042.GU90_04150	5.052e-188	602.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4DZZ7@85010|Pseudonocardiales	201174|Actinobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
TLS2_k127_338345_3	43759.JNWK01000007_gene1857	2.607e-56	209.0	COG3415@1|root,COG3415@2|Bacteria,2HK0D@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,Terminase_5
TLS2_k127_338345_2	479435.Kfla_5713	3.719e-130	428.0	COG1398@1|root,COG1398@2|Bacteria,2GJJF@201174|Actinobacteria,4DQ24@85009|Propionibacteriales	201174|Actinobacteria	I	Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
TLS2_k127_340587_0	1223523.H340_14331	9.187e-309	954.0	COG1061@1|root,COG1061@2|Bacteria,2GIR9@201174|Actinobacteria	201174|Actinobacteria	L	helicase	ercc3	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
TLS2_k127_341612_0	1298863.AUEP01000011_gene660	7.221e-191	597.0	COG1082@1|root,COG1082@2|Bacteria,2GK1S@201174|Actinobacteria,4DNDR@85009|Propionibacteriales	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS2_k127_341612_2	1160718.SU9_21342	1.212e-124	418.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	hrdA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_341612_1	1122138.AQUZ01000055_gene6239	3.603e-150	490.0	COG2141@1|root,COG4639@1|root,COG2141@2|Bacteria,COG4639@2|Bacteria,2GM7W@201174|Actinobacteria,4DPZ7@85009|Propionibacteriales	201174|Actinobacteria	C	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,Bac_luciferase
TLS2_k127_341612_5	1298863.AUEP01000005_gene2528	1.043e-25	113.0	COG0776@1|root,COG0776@2|Bacteria,2GTF6@201174|Actinobacteria,4DS6N@85009|Propionibacteriales	201174|Actinobacteria	L	regulation of translation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_341612_3	1120936.KB907215_gene3984	1.026e-120	399.0	COG3569@1|root,COG3569@2|Bacteria,2GJTH@201174|Actinobacteria,4EI0T@85012|Streptosporangiales	201174|Actinobacteria	L	Eukaryotic DNA topoisomerase I, catalytic core	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
TLS2_k127_341612_4	471853.Bcav_4134	4.547e-39	151.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	atsD	GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004065,GO:0004098,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005783,GO:0005788,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006687,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008150,GO:0008152,GO:0008484,GO:0009987,GO:0012505,GO:0016192,GO:0016787,GO:0016788,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034774,GO:0035578,GO:0036230,GO:0042119,GO:0042582,GO:0043167,GO:0043169,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044255,GO:0044422,GO:0044424,GO:0044432,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046872,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0071704,GO:0097708,GO:0099503,GO:1901135,GO:1901564,GO:1903509	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
TLS2_k127_343171_3	471853.Bcav_3378	1.918e-101	339.0	COG3275@1|root,COG3275@2|Bacteria,2GJD4@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
TLS2_k127_343171_2	58123.JOFJ01000012_gene5412	8.819e-123	400.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4ENNZ@85012|Streptosporangiales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_343171_0	58123.JOFJ01000012_gene5413	2.689e-142	468.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4EPCM@85012|Streptosporangiales	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_343171_4	1236902.ANAS01000030_gene3004	3.329e-58	212.0	COG3177@1|root,COG3177@2|Bacteria,2GIT8@201174|Actinobacteria,4EG60@85012|Streptosporangiales	201174|Actinobacteria	S	Filamentation induced by cAMP protein fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic
TLS2_k127_343171_1	35754.JNYJ01000043_gene4419	5.621e-130	423.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4D9RI@85008|Micromonosporales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS2_k127_343171_5	1172179.AUKV01000042_gene351	1.455e-19	104.0	COG1309@1|root,COG1309@2|Bacteria,2GYI1@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_343171_6	1077974.GOEFS_094_00430	6.08e-05	53.0	COG1309@1|root,COG1309@2|Bacteria,2GYI1@201174|Actinobacteria,4GE17@85026|Gordoniaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_3468833_1	2074.JNYD01000009_gene5170	2.965e-155	499.0	COG1299@1|root,COG1445@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,2GJU4@201174|Actinobacteria,4E0S5@85010|Pseudonocardiales	201174|Actinobacteria	G	PTS system, Lactose/Cellobiose specific IIB subunit	fruA	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
TLS2_k127_3468833_0	471853.Bcav_1928	5.461e-214	672.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA2	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS2_k127_3513326_2	1298863.AUEP01000014_gene1616	9.477e-173	550.0	COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,4DNI1@85009|Propionibacteriales	201174|Actinobacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3858c	Fer4_20,Pyr_redox_2
TLS2_k127_3513326_0	1298863.AUEP01000014_gene1615	0.0	2381.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,2GN09@201174|Actinobacteria,4DP8G@85009|Propionibacteriales	201174|Actinobacteria	E	GXGXG motif	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TLS2_k127_3513326_6	58123.JOFJ01000001_gene2988	2.218e-86	292.0	COG1814@1|root,COG1814@2|Bacteria,2GIZ3@201174|Actinobacteria,4EHQV@85012|Streptosporangiales	201174|Actinobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
TLS2_k127_3513326_3	1137269.AZWL01000008_gene4784	2.325e-136	440.0	COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria	201174|Actinobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	-	-	-	-	-	-	-	-	-	LGT
TLS2_k127_3513326_8	1380393.JHVP01000007_gene4459	1.853e-30	137.0	COG1651@1|root,COG1651@2|Bacteria,2GKH8@201174|Actinobacteria,4ETBH@85013|Frankiales	201174|Actinobacteria	O	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
TLS2_k127_3513326_7	67352.JODS01000001_gene383	2.917e-43	167.0	COG2259@1|root,COG2259@2|Bacteria,2IQEY@201174|Actinobacteria	201174|Actinobacteria	O	DoxX family	-	-	-	-	-	-	-	-	-	-	-	-	DoxX,MauE
TLS2_k127_3513326_5	469371.Tbis_1452	8.583e-102	347.0	COG0159@1|root,COG0159@2|Bacteria,2GN6T@201174|Actinobacteria,4E01I@85010|Pseudonocardiales	201174|Actinobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
TLS2_k127_3513326_1	1306174.JODP01000013_gene7463	1.207e-197	632.0	COG0133@1|root,COG0133@2|Bacteria,2GM7Z@201174|Actinobacteria	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PALP
TLS2_k127_3513326_4	1120950.KB892707_gene4966	2.239e-122	407.0	COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,4DNTB@85009|Propionibacteriales	201174|Actinobacteria	E	Indole-3-glycerol phosphate synthase	trpC	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
TLS2_k127_3513326_9	1206741.BAFX01000142_gene2725	1.034e-05	56.0	2EGCD@1|root,33A46@2|Bacteria,2GR1I@201174|Actinobacteria,4G2WY@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
TLS2_k127_3513326_10	196162.Noca_3029	9.106e-05	46.0	2E37T@1|root,32Y7G@2|Bacteria,2GQH5@201174|Actinobacteria,4DSJ1@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
TLS2_k127_3519175_4	1048339.KB913029_gene1929	6.682e-10	67.0	2E37T@1|root,32Y7G@2|Bacteria,2HKTZ@201174|Actinobacteria,4EWSP@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
TLS2_k127_3519175_3	1463887.KL589971_gene4496	9.533e-12	74.0	290XR@1|root,2ZNJH@2|Bacteria,2IQ97@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3519175_2	219305.MCAG_01173	1.973e-17	95.0	2EGC7@1|root,33A40@2|Bacteria,2HEC9@201174|Actinobacteria,4DEKU@85008|Micromonosporales	201174|Actinobacteria	S	Tryptophan-associated transmembrane protein (Trp_oprn_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Trp_oprn_chp
TLS2_k127_3519175_0	1120950.KB892707_gene4953	6.825e-236	739.0	COG1169@1|root,COG1169@2|Bacteria,2I50A@201174|Actinobacteria,4DX2J@85009|Propionibacteriales	201174|Actinobacteria	HQ	Anthranilate synthase component I, N terminal region	trpE	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004049,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS2_k127_3519175_1	1122609.AUGT01000012_gene4349	2.103e-61	214.0	COG0139@1|root,COG0139@2|Bacteria,2IKKU@201174|Actinobacteria,4DR51@85009|Propionibacteriales	201174|Actinobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	GO:0008150,GO:0040007	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1606	PRA-CH
TLS2_k127_3534639_0	397278.JOJN01000001_gene2751	3.27e-265	826.0	COG0119@1|root,COG0119@2|Bacteria,2GKYT@201174|Actinobacteria,4DNDJ@85009|Propionibacteriales	201174|Actinobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA2	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS2_k127_3534639_1	1120950.KB892741_gene2679	8.199e-177	566.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4DPRZ@85009|Propionibacteriales	201174|Actinobacteria	E	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS2_k127_3534639_2	1150864.MILUP08_42307	9.789e-31	126.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4D8SX@85008|Micromonosporales	201174|Actinobacteria	V	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_3537474_0	1193181.BN10_460045	1.474e-161	523.0	COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,2GIZP@201174|Actinobacteria,4FESC@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acetyl-CoA carboxylase, central region	-	-	-	-	-	-	-	-	-	-	-	-	ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
TLS2_k127_3551906_4	1283283.ATXA01000012_gene4811	1.774e-31	139.0	COG0454@1|root,COG0456@2|Bacteria,2IAC7@201174|Actinobacteria,4EVG0@85013|Frankiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	aac	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008080,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016020,GO:0016137,GO:0016139,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017001,GO:0017144,GO:0030647,GO:0030649,GO:0034069,GO:0044237,GO:0044248,GO:0044464,GO:0047921,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658	2.3.1.59	ko:K17840	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_9
TLS2_k127_3551906_1	66377.JOBH01000001_gene1418	3.344e-80	286.0	COG4552@1|root,COG4552@2|Bacteria,2GNXZ@201174|Actinobacteria	201174|Actinobacteria	S	N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
TLS2_k127_3551906_3	1394178.AWOO02000055_gene827	1.188e-31	128.0	292KZ@1|root,2ZQ4W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3551906_0	526225.Gobs_0825	1.321e-95	323.0	COG3380@1|root,COG3380@2|Bacteria,2IA89@201174|Actinobacteria,4EUK4@85013|Frankiales	201174|Actinobacteria	S	Flavin containing amine oxidoreductase	-	-	-	ko:K06955	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
TLS2_k127_3551906_2	1121377.KB906399_gene1534	1.99e-37	158.0	COG1051@1|root,COG1051@2|Bacteria,1WN9T@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Hydrolase of X-linked nucleoside diphosphate N terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N
TLS2_k127_3555993_5	103733.JNYO01000013_gene4280	8.058e-124	407.0	COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4DYUC@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM CoA-transferase family III	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
TLS2_k127_3555993_12	1032480.MLP_47110	1.09e-71	248.0	COG1309@1|root,COG1309@2|Bacteria,2IJP2@201174|Actinobacteria,4DSE4@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_3555993_27	37919.EP51_00195	1.701e-14	77.0	COG0654@1|root,COG0654@2|Bacteria,2GKUZ@201174|Actinobacteria,4FYKD@85025|Nocardiaceae	201174|Actinobacteria	CH	FAD binding domain	sppF	-	1.14.13.200	ko:K14672,ko:K15972	ko01057,ko01130,map01057,map01130	M00783	R06704,R10954	RC02681	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	FAD_binding_3
TLS2_k127_3555993_2	298653.Franean1_0937	9.78e-172	556.0	COG1524@1|root,COG1524@2|Bacteria	2|Bacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PE,Phosphodiest
TLS2_k127_3555993_28	1996.JOFO01000065_gene2002	1.637e-12	68.0	2ER9N@1|root,33IV9@2|Bacteria,2GSJ1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3555993_1	1120950.KB892749_gene3356	2.513e-198	628.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4DNKT@85009|Propionibacteriales	201174|Actinobacteria	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1,APH
TLS2_k127_3555993_14	1242864.D187_006563	1.988e-67	240.0	COG3823@1|root,COG3823@2|Bacteria,1R9YU@1224|Proteobacteria,42RYU@68525|delta/epsilon subdivisions,2WNVI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM Glutamine cyclotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_cyclase_2
TLS2_k127_3555993_19	1048339.KB913029_gene2929	3.094e-49	194.0	COG0476@1|root,COG0476@2|Bacteria,2GMJI@201174|Actinobacteria,4ET5V@85013|Frankiales	201174|Actinobacteria	H	UBA THIF-type NAD FAD binding	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
TLS2_k127_3555993_25	1032480.MLP_31550	7.793e-24	105.0	2E479@1|root,32Z35@2|Bacteria,2GQXY@201174|Actinobacteria,4DS56@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3555993_13	1454010.JEOE01000028_gene970	1.76e-68	242.0	COG1451@1|root,COG1451@2|Bacteria,2GMP6@201174|Actinobacteria,4F1PC@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
TLS2_k127_3555993_15	1122138.AQUZ01000040_gene6219	1.126e-65	229.0	COG1522@1|root,COG1522@2|Bacteria,2GMSR@201174|Actinobacteria,4DRS3@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS2_k127_3555993_3	644283.Micau_4395	2.616e-165	539.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4DB6Q@85008|Micromonosporales	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS2_k127_3555993_4	1123320.KB889672_gene3687	2.549e-138	475.0	COG5282@1|root,COG5282@2|Bacteria,2GJ9K@201174|Actinobacteria	201174|Actinobacteria	H	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
TLS2_k127_3555993_7	1120950.KB892749_gene3343	7.058e-118	407.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria	201174|Actinobacteria	GM	Epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS2_k127_3555993_17	467200.ACFA01000321_gene5850	6.333e-53	194.0	COG0314@1|root,COG0314@2|Bacteria,2IQ9F@201174|Actinobacteria	201174|Actinobacteria	H	Molybdopterin	moaE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.12	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
TLS2_k127_3555993_9	1120950.KB892749_gene3341	8.13e-95	323.0	COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria,4DQEN@85009|Propionibacteriales	201174|Actinobacteria	T	Domain present in PSD-95, Dlg, and ZO-1/2.	ylbL	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
TLS2_k127_3555993_18	471852.Tcur_3729	1.134e-49	184.0	2DA1Q@1|root,32TUF@2|Bacteria,2GKR3@201174|Actinobacteria,4EK7A@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3555993_0	1120950.KB892749_gene3340	0.0	1114.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4DQ0K@85009|Propionibacteriales	201174|Actinobacteria	T	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
TLS2_k127_3555993_26	526225.Gobs_3629	1.111e-14	79.0	COG3631@1|root,COG3631@2|Bacteria	2|Bacteria	S	light absorption	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
TLS2_k127_3555993_6	930171.Asphe3_09300	3.878e-120	390.0	COG0640@1|root,COG3832@1|root,COG0640@2|Bacteria,COG3832@2|Bacteria,2GNW2@201174|Actinobacteria,1WADX@1268|Micrococcaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,HTH_20
TLS2_k127_3555993_23	479433.Caci_5113	1.481e-36	142.0	COG0346@1|root,COG0346@2|Bacteria,2IS2C@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_3555993_29	1538295.JY96_03560	5.63e-09	60.0	COG3324@1|root,COG3324@2|Bacteria,1N1P5@1224|Proteobacteria,2W3PV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_3555993_11	1298880.AUEV01000017_gene1123	2.819e-75	264.0	COG2253@1|root,COG2253@2|Bacteria,2GP8Y@201174|Actinobacteria	201174|Actinobacteria	K	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
TLS2_k127_3555993_21	469383.Cwoe_5577	1.543e-43	166.0	COG5340@1|root,COG5340@2|Bacteria,2H7VR@201174|Actinobacteria	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4
TLS2_k127_3555993_22	110319.CF8_0508	3.864e-40	151.0	COG3070@1|root,COG3070@2|Bacteria,2IKPV@201174|Actinobacteria	201174|Actinobacteria	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
TLS2_k127_3555993_10	1385520.N802_04530	3.913e-90	314.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_3555993_8	1385520.N802_04535	5.794e-106	366.0	COG4585@1|root,COG4585@2|Bacteria,2IIHD@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS2_k127_3555993_16	1385520.N802_04545	1.082e-60	220.0	2ES89@1|root,33JSX@2|Bacteria,2GW9S@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3555993_24	408672.NBCG_02294	1.826e-33	135.0	COG3795@1|root,COG3795@2|Bacteria,2HZ8Z@201174|Actinobacteria,4DR9A@85009|Propionibacteriales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_3556949_4	196162.Noca_1258	3.416e-06	57.0	2EBSZ@1|root,335SP@2|Bacteria,2GYW5@201174|Actinobacteria,4DSNV@85009|Propionibacteriales	201174|Actinobacteria	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
TLS2_k127_3556949_2	266940.Krad_3785	3.57e-21	103.0	2E9Y4@1|root,3343S@2|Bacteria,2GR3H@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3556949_1	1120950.KB892764_gene5645	4.279e-23	103.0	2CXFQ@1|root,32T1V@2|Bacteria,2GQYH@201174|Actinobacteria,4DRHS@85009|Propionibacteriales	201174|Actinobacteria	S	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS2_k127_3556949_3	1043493.BBLU01000008_gene411	1.077e-13	73.0	2EG89@1|root,33A03@2|Bacteria,2GX3U@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3556949_0	298653.Franean1_5824	2.356e-32	127.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,4ESC6@85013|Frankiales	201174|Actinobacteria	NU	Type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_3594128_5	1032480.MLP_44130	0.0003691	51.0	COG4409@1|root,COG4409@2|Bacteria,2IG16@201174|Actinobacteria,4DW80@85009|Propionibacteriales	201174|Actinobacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3594128_0	1120950.KB892795_gene2290	9.201e-96	329.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4DQKI@85009|Propionibacteriales	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
TLS2_k127_3594128_3	326424.FRAAL0946	3.083e-54	193.0	COG2044@1|root,COG2044@2|Bacteria,2IHT6@201174|Actinobacteria	201174|Actinobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
TLS2_k127_3594128_1	479433.Caci_8243	2.024e-66	232.0	COG4044@1|root,COG4044@2|Bacteria,2GKGF@201174|Actinobacteria	201174|Actinobacteria	S	May play a role in the intracellular transport of hydrophobic ligands	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF1794
TLS2_k127_3594128_2	1348663.KCH_43240	2.911e-54	195.0	COG0735@1|root,COG0735@2|Bacteria,2IFHB@201174|Actinobacteria,2M2S8@2063|Kitasatospora	201174|Actinobacteria	P	Ferric uptake regulator family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_3594128_4	1312959.KI914640_gene1414	9.71e-21	95.0	COG0354@1|root,COG0354@2|Bacteria,2GKP0@201174|Actinobacteria,1W7NK@1268|Micrococcaceae	201174|Actinobacteria	S	Belongs to the GcvT family	ygfZ	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
TLS2_k127_3614697_11	40571.JOEA01000003_gene3484	5.066e-12	70.0	COG1309@1|root,COG1309@2|Bacteria,2HD07@201174|Actinobacteria,4DZCN@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_3614697_2	1122182.KB903837_gene3906	1.163e-114	382.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4D8QU@85008|Micromonosporales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3614697_9	1246995.AFR_08775	3.806e-59	220.0	COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria,4DCGZ@85008|Micromonosporales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS2_k127_3614697_7	526225.Gobs_1059	9.56e-73	254.0	29UQ5@1|root,30G1W@2|Bacteria,2II02@201174|Actinobacteria,4EV3Q@85013|Frankiales	201174|Actinobacteria	C	spheroidene monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3614697_1	1048339.KB913029_gene4357	7.195e-181	583.0	COG1233@1|root,COG1233@2|Bacteria,2IE6C@201174|Actinobacteria,4EUVU@85013|Frankiales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	crtO	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS2_k127_3614697_0	1463821.JOGR01000007_gene37	3.858e-262	818.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,4EXQQ@85014|Glycomycetales	201174|Actinobacteria	J	tRNA synthetase class II core domain (G, H, P, S and T)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
TLS2_k127_3614697_3	1125971.ASJB01000049_gene4836	1.558e-96	342.0	COG5438@1|root,COG5438@2|Bacteria,2GKJ4@201174|Actinobacteria,4DY5S@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM YibE F-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YibE_F
TLS2_k127_3614697_12	1236902.ANAS01000009_gene2592	8.439e-10	67.0	2C98I@1|root,33EGA@2|Bacteria,2IQRU@201174|Actinobacteria,4EKFZ@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3614697_5	1146883.BLASA_1558	1.246e-88	320.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,4ET8X@85013|Frankiales	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	scbA	-	-	ko:K02077,ko:K09815,ko:K09818	ko02010,map02010	M00242,M00243,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
TLS2_k127_3614697_6	1211815.CBYP010000015_gene2823	7.323e-77	269.0	COG1121@1|root,COG1121@2|Bacteria,2GP3A@201174|Actinobacteria,4EX4V@85013|Frankiales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	mntB	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
TLS2_k127_3614697_4	1146883.BLASA_1556	1.381e-92	314.0	COG1108@1|root,COG1108@2|Bacteria,2GJ7H@201174|Actinobacteria,4ETAC@85013|Frankiales	201174|Actinobacteria	P	PFAM ABC-3 protein	-	-	-	ko:K09816,ko:K09819	ko02010,map02010	M00242,M00243	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
TLS2_k127_3614697_10	649831.L083_1621	1.619e-29	128.0	COG0640@1|root,COG0640@2|Bacteria,2IMSD@201174|Actinobacteria,4DF3A@85008|Micromonosporales	201174|Actinobacteria	K	transcriptional	smtB	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0044212,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K22298	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
TLS2_k127_3614697_8	235985.BBPN01000007_gene3355	4.457e-61	218.0	COG0735@1|root,COG0735@2|Bacteria,2IKS3@201174|Actinobacteria,2NI9X@228398|Streptacidiphilus	201174|Actinobacteria	P	Ferric uptake regulator family	furB	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_3650412_2	1380346.JNIH01000062_gene2509	1.272e-191	607.0	COG0162@1|root,COG0162@2|Bacteria,2GJPR@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TLS2_k127_3650412_7	1120950.KB892768_gene5195	5.833e-71	248.0	COG2094@1|root,COG2094@2|Bacteria,2GNW1@201174|Actinobacteria,4DQWP@85009|Propionibacteriales	201174|Actinobacteria	L	Belongs to the DNA glycosylase MPG family	alkA	GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
TLS2_k127_3650412_0	1121017.AUFG01000014_gene1971	2.331e-228	717.0	COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,4FF12@85021|Intrasporangiaceae	201174|Actinobacteria	E	Argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
TLS2_k127_3650412_1	1454010.JEOE01000030_gene2841	7.09e-213	679.0	COG0137@1|root,COG0137@2|Bacteria,2GK96@201174|Actinobacteria,4F0X0@85016|Cellulomonadaceae	201174|Actinobacteria	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0071944,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iNJ661.Rv1658	Arginosuc_synth
TLS2_k127_3650412_8	1122138.AQUZ01000041_gene7298	1.119e-54	215.0	COG1438@1|root,COG1438@2|Bacteria,2GKA5@201174|Actinobacteria,4DQUP@85009|Propionibacteriales	201174|Actinobacteria	K	Regulates arginine biosynthesis genes	argR	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
TLS2_k127_3650412_4	266940.Krad_3158	4.179e-149	504.0	COG4992@1|root,COG4992@2|Bacteria,2GKE9@201174|Actinobacteria	201174|Actinobacteria	E	acetylornithine aminotransferase	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0008150,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_3650412_6	1120950.KB892768_gene5201	3.089e-133	449.0	COG0548@1|root,COG0548@2|Bacteria,2GKDS@201174|Actinobacteria,4DPCE@85009|Propionibacteriales	201174|Actinobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
TLS2_k127_3650412_3	1048339.KB913029_gene4047	6.427e-156	516.0	COG1364@1|root,COG1364@2|Bacteria,2GIW0@201174|Actinobacteria,4ES7A@85013|Frankiales	201174|Actinobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
TLS2_k127_3650412_5	351607.Acel_1263	2.163e-136	441.0	COG0002@1|root,COG0002@2|Bacteria,2GKQK@201174|Actinobacteria,4ES9C@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_3659040_1	1120950.KB892762_gene5462	2.988e-110	366.0	COG0455@1|root,COG0455@2|Bacteria,2GIVN@201174|Actinobacteria,4DWZF@85009|Propionibacteriales	201174|Actinobacteria	D	bacterial-type flagellum organization	cpaE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	CbiA
TLS2_k127_3659040_0	58344.JOEL01000007_gene4504	4.199e-143	464.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria	201174|Actinobacteria	U	Type ii secretion system protein e	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS2_k127_3659040_2	935866.JAER01000021_gene800	6.796e-36	155.0	COG4965@1|root,COG4965@2|Bacteria,2I8NR@201174|Actinobacteria,4DRXI@85009|Propionibacteriales	201174|Actinobacteria	U	Type ii secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_3679636_9	1306174.JODP01000009_gene6552	3.856e-27	122.0	2DS3G@1|root,33ECD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TbpB_B_D,Transglut_core
TLS2_k127_3679636_6	105420.BBPO01000029_gene6808	9.647e-51	203.0	COG0316@1|root,COG0316@2|Bacteria,2IHR0@201174|Actinobacteria,2NIVX@228398|Streptacidiphilus	201174|Actinobacteria	S	Iron-sulphur cluster biosynthesis	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0071944,GO:1901564	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TLS2_k127_3679636_1	1120950.KB892707_gene4781	1.876e-137	452.0	COG1929@1|root,COG1929@2|Bacteria,2GKHX@201174|Actinobacteria,4DMYU@85009|Propionibacteriales	201174|Actinobacteria	G	Belongs to the glycerate kinase type-1 family	glxK	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
TLS2_k127_3679636_4	1120950.KB892707_gene4780	3.255e-87	295.0	COG0454@1|root,COG0454@2|Bacteria,2H2PG@201174|Actinobacteria,4DNDQ@85009|Propionibacteriales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
TLS2_k127_3679636_0	263358.VAB18032_27291	9.718e-207	647.0	COG0379@1|root,COG0379@2|Bacteria,2GM59@201174|Actinobacteria,4D97S@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
TLS2_k127_3679636_5	561175.KB894094_gene1456	6.536e-78	265.0	arCOG04740@1|root,31PZA@2|Bacteria,2GP15@201174|Actinobacteria,4EIMY@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3679636_3	2002.JOEQ01000006_gene1471	1.232e-107	356.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4EGS5@85012|Streptosporangiales	201174|Actinobacteria	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS2_k127_3679636_10	67315.JOBD01000013_gene6984	8.39e-26	109.0	2E3Z4@1|root,32YW2@2|Bacteria,2IQZ7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3679636_2	1449353.JQMQ01000005_gene4724	4.092e-108	358.0	COG1842@1|root,COG1842@2|Bacteria,2GP0K@201174|Actinobacteria,2NEDP@228398|Streptacidiphilus	201174|Actinobacteria	KT	PspA/IM30 family	pspA	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
TLS2_k127_3679636_7	1120950.KB892707_gene4775	6.413e-48	181.0	2AN86@1|root,31D67@2|Bacteria,2HWWU@201174|Actinobacteria,4DRVQ@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF3043)	-	GO:0008150,GO:0009605,GO:0009607,GO:0020012,GO:0030682,GO:0042783,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	-	-	-	-	-	-	-	-	-	DUF3043
TLS2_k127_3679636_8	1120934.KB894408_gene4772	3.452e-41	162.0	COG0454@1|root,COG0456@2|Bacteria,2IFF2@201174|Actinobacteria,4E3HI@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_3679636_11	471852.Tcur_3087	2.495e-24	105.0	COG0667@1|root,COG0667@2|Bacteria,2GMT5@201174|Actinobacteria,4EG7B@85012|Streptosporangiales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_3713324_4	1288079.AUKN01000007_gene1777	4.861e-46	171.0	COG5006@1|root,COG5006@2|Bacteria,2GJKB@201174|Actinobacteria	201174|Actinobacteria	K	permease, DMT superfamily	-	-	-	ko:K11939	-	-	-	-	ko00000,ko02000	2.A.7.3.6	-	-	EamA
TLS2_k127_3713324_1	253839.SSNG_04068	1.456e-98	336.0	COG0583@1|root,COG0583@2|Bacteria,2I8Y8@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_3713324_0	1238186.AOCN01000007_gene579	1.354e-155	504.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4FKZ0@85023|Microbacteriaceae	201174|Actinobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_3713324_2	1380347.JNII01000006_gene1625	3.624e-74	259.0	COG1277@1|root,COG1277@2|Bacteria,2GJ2R@201174|Actinobacteria,4ESPB@85013|Frankiales	201174|Actinobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
TLS2_k127_3713324_3	1380347.JNII01000006_gene1624	9.053e-63	219.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4ESC8@85013|Frankiales	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_3719733_1	1306174.JODP01000001_gene5283	6.724e-305	940.0	COG2987@1|root,COG2987@2|Bacteria,2GP10@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
TLS2_k127_3719733_4	1123023.JIAI01000002_gene4963	1.195e-151	492.0	COG0624@1|root,COG0624@2|Bacteria,2GJDE@201174|Actinobacteria,4DXJV@85010|Pseudonocardiales	201174|Actinobacteria	E	Peptidase family M28	amaB	-	3.5.1.6,3.5.1.87,3.5.3.9	ko:K02083,ko:K06016	ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120	M00046	R00905,R02423,R04666	RC00064,RC00096	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_3719733_6	2002.JOEQ01000012_gene5715	1.716e-65	245.0	29QD5@1|root,30BCD@2|Bacteria,2IG1I@201174|Actinobacteria,4EGQ5@85012|Streptosporangiales	201174|Actinobacteria	S	Family of unknown function (DUF695)	-	-	-	-	-	-	-	-	-	-	-	-	DUF695
TLS2_k127_3719733_3	1449976.KALB_7843	4.668e-173	556.0	COG0402@1|root,COG0402@2|Bacteria,2GZ2Q@201174|Actinobacteria,4DXKJ@85010|Pseudonocardiales	201174|Actinobacteria	F	Formiminoglutamate deiminase	hutF	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_3719733_2	1463864.JOGO01000020_gene3377	3.315e-175	563.0	COG1228@1|root,COG1228@2|Bacteria,2GJH4@201174|Actinobacteria	201174|Actinobacteria	Q	Catalyzes the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
TLS2_k127_3719733_7	28444.JODQ01000001_gene2418	1.575e-22	101.0	2E3I3@1|root,32YGJ@2|Bacteria,2GV2N@201174|Actinobacteria,4EPM9@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF3467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3467
TLS2_k127_3719733_5	2074.JNYD01000001_gene6196	7.463e-73	265.0	COG3503@1|root,COG3503@2|Bacteria,2I2JM@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF418
TLS2_k127_3719733_8	1048339.KB913029_gene3867	1.161e-20	96.0	2DR0Y@1|root,339QH@2|Bacteria,2GWIF@201174|Actinobacteria,4ETJG@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF4235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4235
TLS2_k127_3719733_0	593907.Celgi_0226	0.0	1191.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria	201174|Actinobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
TLS2_k127_3737211_6	1120950.KB892709_gene4053	1.107e-75	286.0	COG1335@1|root,COG1335@2|Bacteria,2IFQW@201174|Actinobacteria,4DQD6@85009|Propionibacteriales	201174|Actinobacteria	Q	Isochorismatase family	pncA	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
TLS2_k127_3737211_0	313589.JNB_06284	9.839e-189	601.0	COG1488@1|root,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria,4FFB9@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
TLS2_k127_3737211_10	1120950.KB892709_gene4055	3.433e-45	166.0	COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria,4DRQZ@85009|Propionibacteriales	201174|Actinobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
TLS2_k127_3737211_9	397278.JOJN01000007_gene3127	9.08e-49	180.0	2E4AX@1|root,32Z6K@2|Bacteria,2GW4T@201174|Actinobacteria,4DQGY@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF2017)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2017
TLS2_k127_3737211_8	1394178.AWOO02000078_gene2035	1.265e-60	222.0	COG1310@1|root,COG1310@2|Bacteria,2IFB5@201174|Actinobacteria,4EJ5N@85012|Streptosporangiales	201174|Actinobacteria	S	JAB/MPN domain	mec	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006508,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016787,GO:0019344,GO:0019538,GO:0019752,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
TLS2_k127_3737211_11	196162.Noca_1311	1.723e-38	147.0	COG1977@1|root,COG1977@2|Bacteria,2IQBT@201174|Actinobacteria,4DRYQ@85009|Propionibacteriales	201174|Actinobacteria	H	ThiS family	cysO	GO:0000096,GO:0000097,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS2_k127_3737211_1	351607.Acel_1687	1.367e-169	539.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4ERDA@85013|Frankiales	201174|Actinobacteria	E	Cysteine synthase	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113	ko:K21148	ko04122,map04122	-	R10610	RC03225	ko00000,ko00001,ko01000	-	-	-	PALP
TLS2_k127_3737211_2	1380347.JNII01000006_gene1973	1.422e-123	403.0	COG0796@1|root,COG0796@2|Bacteria,2GN4I@201174|Actinobacteria,4ERE1@85013|Frankiales	201174|Actinobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
TLS2_k127_3737211_4	1394178.AWOO02000078_gene2041	5.845e-97	322.0	COG1234@1|root,COG1234@2|Bacteria,2GMEX@201174|Actinobacteria,4EIG9@85012|Streptosporangiales	201174|Actinobacteria	S	Beta-lactamase superfamily domain	yhfI	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS2_k127_3737211_3	479435.Kfla_1847	7.155e-119	385.0	COG2123@1|root,COG2123@2|Bacteria,2I466@201174|Actinobacteria,4DX26@85009|Propionibacteriales	201174|Actinobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
TLS2_k127_3737211_5	1003195.SCAT_1935	3.425e-78	280.0	COG0127@1|root,COG0127@2|Bacteria,2GM2B@201174|Actinobacteria	201174|Actinobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
TLS2_k127_3737211_7	710111.FraQA3DRAFT_1774	4.051e-65	226.0	COG3651@1|root,COG3651@2|Bacteria,2IHNI@201174|Actinobacteria,4EVHX@85013|Frankiales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2237)	-	-	-	ko:K09966	-	-	-	-	ko00000	-	-	-	DUF2237
TLS2_k127_3737211_12	1463920.JOGB01000005_gene1823	2.693e-23	108.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria	201174|Actinobacteria	M	Oxidoreductase molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
TLS2_k127_3750655_8	675812.VHA_002641	7.786e-59	212.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1XZWA@135623|Vibrionales	135623|Vibrionales	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_3750655_3	463191.SSEG_09286	7.546e-152	501.0	COG1071@1|root,COG1071@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	-	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K11381,ko:K21416	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS2_k127_3750655_1	351607.Acel_1043	1.216e-261	809.0	COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria,4ESAX@85013|Frankiales	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
TLS2_k127_3750655_6	463191.SSEG_03706	6.469e-81	275.0	COG3620@1|root,COG3837@1|root,COG3620@2|Bacteria,COG3837@2|Bacteria,2I4X7@201174|Actinobacteria	201174|Actinobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
TLS2_k127_3750655_9	1120950.KB892768_gene5363	8.045e-45	164.0	COG0011@1|root,COG0011@2|Bacteria,2IQ7E@201174|Actinobacteria,4DR5J@85009|Propionibacteriales	201174|Actinobacteria	S	Thiamine-binding protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
TLS2_k127_3750655_5	44060.JODL01000018_gene4656	5.959e-112	373.0	COG0644@1|root,COG0644@2|Bacteria,2GMH9@201174|Actinobacteria	201174|Actinobacteria	C	geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS2_k127_3750655_0	477641.MODMU_0207	0.0	1146.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4ERP5@85013|Frankiales	201174|Actinobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_3750655_2	1449068.JMLQ01000001_gene11	1.625e-188	606.0	COG0402@1|root,COG0402@2|Bacteria,2GM63@201174|Actinobacteria,4FU15@85025|Nocardiaceae	201174|Actinobacteria	F	Amidohydrolase family	atzB	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_3750655_7	675635.Psed_1762	3.734e-75	257.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria,4E2JM@85010|Pseudonocardiales	201174|Actinobacteria	C	[2Fe-2S] binding domain	coxS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_3750655_4	2074.JNYD01000010_gene996	3.93e-122	399.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4DZYT@85010|Pseudonocardiales	201174|Actinobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_3750655_10	1121272.KB903255_gene5775	1.672e-22	111.0	2ENA9@1|root,33FXZ@2|Bacteria,2IS82@201174|Actinobacteria,4DF28@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3750655_11	330084.JNYZ01000027_gene8254	4.851e-12	77.0	2F3VX@1|root,33JN7@2|Bacteria,2ISR1@201174|Actinobacteria,4EEEH@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3751448_6	1151118.KB895810_gene2165	1.135e-35	147.0	COG5516@1|root,COG5516@2|Bacteria	2|Bacteria	S	CGNR zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
TLS2_k127_3751448_7	1214101.BN159_0369	1.079e-08	66.0	COG2220@1|root,COG2220@2|Bacteria,2GMTR@201174|Actinobacteria	201174|Actinobacteria	E	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
TLS2_k127_3751448_1	1120950.KB892830_gene5042	4.085e-164	539.0	COG4346@1|root,COG4346@2|Bacteria,2GITT@201174|Actinobacteria,4DWGK@85009|Propionibacteriales	201174|Actinobacteria	O	C-terminal four TMM region of protein-O-mannosyltransferase	pmt	GO:0000030,GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006493,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0019538,GO:0034645,GO:0035268,GO:0035269,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	PMT,PMT_2,PMT_4TMC
TLS2_k127_3751448_2	1463934.JOCF01000031_gene4911	6.54e-120	404.0	COG0313@1|root,COG0313@2|Bacteria,2GJ9Q@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
TLS2_k127_3751448_0	1306174.JODP01000001_gene4899	1.93e-322	1002.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria	201174|Actinobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
TLS2_k127_3751448_3	397278.JOJN01000012_gene2166	1.306e-102	344.0	COG0084@1|root,COG0084@2|Bacteria,2GMJJ@201174|Actinobacteria,4DPJ5@85009|Propionibacteriales	201174|Actinobacteria	L	TatD related DNase	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
TLS2_k127_3751448_4	1032480.MLP_45100	6.407e-95	327.0	COG3583@1|root,COG3583@2|Bacteria,2H4RU@201174|Actinobacteria,4DMZZ@85009|Propionibacteriales	201174|Actinobacteria	M	G5	rlpA	-	-	ko:K21688	-	-	-	-	ko00000	-	-	-	DUF348,G5,Transglycosylas
TLS2_k127_3751448_5	710696.Intca_0099	9.158e-47	169.0	COG4947@1|root,COG4947@2|Bacteria,2I9H9@201174|Actinobacteria,4FFF6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
TLS2_k127_3779716_7	1906.SFRA_10535	1.244e-102	341.0	COG1597@1|root,COG1597@2|Bacteria,2GK3P@201174|Actinobacteria	201174|Actinobacteria	I	Diacylglycerol kinase	dagK	GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
TLS2_k127_3779716_9	65497.JODV01000005_gene1080	5.792e-38	149.0	COG0071@1|root,COG0071@2|Bacteria,2HUE8@201174|Actinobacteria,4E6ZS@85010|Pseudonocardiales	201174|Actinobacteria	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS2_k127_3779716_0	1123322.KB904647_gene1742	0.0	1190.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria	201174|Actinobacteria	L	DEAD DEAH box helicase	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
TLS2_k127_3779716_6	1134445.AJJM01000039_gene1288	7.18e-126	409.0	COG0258@1|root,COG0258@2|Bacteria,2GKTZ@201174|Actinobacteria	201174|Actinobacteria	L	5'-3' exonuclease	polA_1	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
TLS2_k127_3779716_4	446470.Snas_0285	8.352e-151	487.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the peptidase M24B family	pepE	-	3.4.13.9	ko:K01271,ko:K01274	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
TLS2_k127_3779716_5	1150864.MILUP08_42435	3.802e-147	481.0	COG0520@1|root,COG0520@2|Bacteria,2GJA4@201174|Actinobacteria,4DC2F@85008|Micromonosporales	201174|Actinobacteria	E	aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_3779716_8	656024.FsymDg_2372	2.023e-60	228.0	COG1522@1|root,COG1522@2|Bacteria,2GK3G@201174|Actinobacteria,4ESKM@85013|Frankiales	201174|Actinobacteria	K	Regulator	lrp_3	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS2_k127_3779716_1	1120950.KB892708_gene4478	4.057e-253	786.0	COG1509@1|root,COG1509@2|Bacteria,2GM2P@201174|Actinobacteria,4DP5B@85009|Propionibacteriales	201174|Actinobacteria	E	lysine 2,3-aminomutase	kamA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	-
TLS2_k127_3779716_3	1120950.KB892708_gene4479	5.955e-154	494.0	COG1063@1|root,COG1063@2|Bacteria,2GK3U@201174|Actinobacteria,4DNB6@85009|Propionibacteriales	201174|Actinobacteria	E	Dehydrogenase	-	-	1.4.1.11	ko:K18012	ko00310,map00310	-	R03349	RC00888	ko00000,ko00001,ko01000	-	-	-	-
TLS2_k127_3779716_2	1157637.KB892124_gene710	1.199e-192	614.0	COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria	201174|Actinobacteria	E	amidohydrolase	ytcJ	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_3779716_10	1385519.N801_08720	1.051e-21	96.0	COG0204@1|root,COG0204@2|Bacteria,2GQVG@201174|Actinobacteria,4FFRT@85021|Intrasporangiaceae	201174|Actinobacteria	I	1-acyl-sn-glycerol-3-phosphate acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_3798967_4	1120949.KB903295_gene2225	1.025e-173	582.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4D96C@85008|Micromonosporales	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,GerE,HTH_31,NB-ARC,TPR_12,Trans_reg_C
TLS2_k127_3798967_6	1386089.N865_20295	1.677e-115	380.0	COG1597@1|root,COG1597@2|Bacteria,2GNNM@201174|Actinobacteria	201174|Actinobacteria	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS2_k127_3798967_10	1120949.KB903328_gene9117	1.201e-75	260.0	COG3247@1|root,COG3247@2|Bacteria,2GSMH@201174|Actinobacteria,4DFMZ@85008|Micromonosporales	201174|Actinobacteria	S	response to pH	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
TLS2_k127_3798967_7	1146883.BLASA_4885	4.645e-104	344.0	COG2132@1|root,COG4454@1|root,COG2132@2|Bacteria,COG4454@2|Bacteria,2GPUP@201174|Actinobacteria,4ES9Q@85013|Frankiales	201174|Actinobacteria	Q	Multicopper oxidase	aniA	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
TLS2_k127_3798967_17	1348663.KCH_70480	5.114e-05	50.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
TLS2_k127_3798967_16	1386089.N865_12355	1.336e-21	100.0	2F7CT@1|root,33ZTV@2|Bacteria,2H68E@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3798967_1	1380356.JNIK01000014_gene3372	6.608e-241	775.0	COG1396@1|root,COG3903@1|root,COG1396@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4EUW7@85013|Frankiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,HTH_31,Trans_reg_C
TLS2_k127_3798967_9	1380356.JNIK01000014_gene3371	7.43e-81	279.0	COG3945@1|root,COG3945@2|Bacteria,2GQQY@201174|Actinobacteria,4EVPS@85013|Frankiales	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS2_k127_3798967_14	1380393.JHVP01000001_gene2421	4.458e-27	113.0	arCOG04557@1|root,32XGC@2|Bacteria,2GUAI@201174|Actinobacteria,4EW94@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3798967_8	1122182.KB903837_gene3780	1.125e-91	312.0	COG0697@1|root,COG0697@2|Bacteria,2I91Y@201174|Actinobacteria,4DF2R@85008|Micromonosporales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_3798967_18	479431.Namu_5240	0.0006003	48.0	COG1249@1|root,COG1249@2|Bacteria,2IDQR@201174|Actinobacteria,4ETY5@85013|Frankiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_3798967_5	196162.Noca_4918	6.995e-132	441.0	COG2197@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,4DT1D@85009|Propionibacteriales	201174|Actinobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HD,HD_5
TLS2_k127_3798967_15	1122182.KB903813_gene2317	2e-24	115.0	COG2020@1|root,COG2020@2|Bacteria,2GTDR@201174|Actinobacteria,4DM6V@85008|Micromonosporales	201174|Actinobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TLS2_k127_3798967_13	710111.FraQA3DRAFT_2723	3.142e-35	139.0	2EB9B@1|root,3359U@2|Bacteria,2GSA6@201174|Actinobacteria,4EW8D@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_3798967_2	1123024.AUII01000016_gene1309	7.134e-196	635.0	COG0507@1|root,COG0507@2|Bacteria,2GJRK@201174|Actinobacteria,4DXGE@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
TLS2_k127_3798967_11	471853.Bcav_0988	1.363e-63	224.0	COG4636@1|root,COG4636@2|Bacteria,2IGTR@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS2_k127_3798967_0	743718.Isova_0816	0.0	1221.0	COG1074@1|root,COG1074@2|Bacteria,2GNKH@201174|Actinobacteria,4F5DF@85017|Promicromonosporaceae	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS2_k127_3798967_3	1032480.MLP_34050	1.777e-181	584.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria,4DPQT@85009|Propionibacteriales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
TLS2_k127_3800076_3	1123321.KB905817_gene5166	2.088e-74	252.0	COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria	201174|Actinobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
TLS2_k127_3800076_4	1449353.JQMQ01000005_gene3675	7.493e-59	217.0	COG0103@1|root,COG0103@2|Bacteria,2GNDY@201174|Actinobacteria,2NFN1@228398|Streptacidiphilus	201174|Actinobacteria	J	Ribosomal protein S9/S16	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
TLS2_k127_3800076_0	1120950.KB892784_gene183	1.571e-201	639.0	COG1109@1|root,COG1109@2|Bacteria,2GN87@201174|Actinobacteria,4DNFP@85009|Propionibacteriales	201174|Actinobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	GO:0008150,GO:0040007	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_3800076_1	675635.Psed_3169	1.191e-142	458.0	COG1072@1|root,COG1072@2|Bacteria,2GIRR@201174|Actinobacteria,4DXVW@85010|Pseudonocardiales	201174|Actinobacteria	H	Pantothenic acid kinase	coaA	GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
TLS2_k127_3800076_2	1476876.JOJO01000001_gene7406	3.786e-94	314.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iNJ661.Rv3436c	GATase_6,SIS
TLS2_k127_3826153_14	1246995.AFR_25175	3.51e-27	114.0	COG0793@1|root,COG0793@2|Bacteria,2HFZM@201174|Actinobacteria	201174|Actinobacteria	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
TLS2_k127_3826153_2	1121272.KB903249_gene1781	3.767e-124	411.0	COG1835@1|root,COG1835@2|Bacteria,2GKUS@201174|Actinobacteria,4DFGJ@85008|Micromonosporales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS2_k127_3826153_9	1068980.ARVW01000001_gene7366	5.613e-64	225.0	COG0346@1|root,COG0346@2|Bacteria,2IMGZ@201174|Actinobacteria,4E4K0@85010|Pseudonocardiales	201174|Actinobacteria	E	glyoxalase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_3826153_1	1123024.AUII01000001_gene3060	6.032e-125	405.0	COG0454@1|root,COG0456@2|Bacteria,2GP2T@201174|Actinobacteria,4E7G3@85010|Pseudonocardiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,Acetyltransf_7
TLS2_k127_3826153_10	794846.AJQU01000111_gene3208	4.481e-59	217.0	COG0596@1|root,COG0596@2|Bacteria,1Q47F@1224|Proteobacteria,2U3WB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_3826153_8	595494.Tola_0290	5.349e-69	243.0	COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,1SAUU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Ribose 5-phosphate isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
TLS2_k127_3826153_3	1380347.JNII01000008_gene4335	3.743e-120	393.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4EUCJ@85013|Frankiales	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_3826153_6	35754.JNYJ01000008_gene3224	3.505e-87	295.0	COG0262@1|root,COG0262@2|Bacteria,2GYU7@201174|Actinobacteria,4DM4I@85008|Micromonosporales	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_3826153_11	1532558.JL39_07180	1.487e-48	175.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,4B9SN@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS2_k127_3826153_0	1095767.CAHD01000029_gene1668	1.495e-164	538.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4F13J@85016|Cellulomonadaceae	201174|Actinobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0016740,GO:0016765,GO:0016829,GO:0016846	-	ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01288	RC00020,RC02848	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0391	Cys_Met_Meta_PP
TLS2_k127_3826153_13	298654.FraEuI1c_7019	1.031e-40	155.0	COG3585@1|root,COG3585@2|Bacteria,2IKQV@201174|Actinobacteria,4ET46@85013|Frankiales	201174|Actinobacteria	H	DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,MerR,TOBE
TLS2_k127_3826153_7	378806.STAUR_1207	1.391e-69	249.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,42P93@68525|delta/epsilon subdivisions,2WUZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
TLS2_k127_3826153_5	443218.AS9A_2359	7.85e-96	330.0	COG4149@1|root,COG4149@2|Bacteria,2GJFB@201174|Actinobacteria	201174|Actinobacteria	P	Molybdate ABC transporter	modB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,BPD_transp_1,TOBE
TLS2_k127_3826153_4	443218.AS9A_2360	1.054e-113	398.0	COG3842@1|root,COG3842@2|Bacteria,2H2JF@201174|Actinobacteria	201174|Actinobacteria	P	ABC transporter	-	-	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,BPD_transp_1,TOBE_2
TLS2_k127_3826153_12	1120950.KB892790_gene2070	2.435e-41	159.0	COG1695@1|root,COG1695@2|Bacteria,2GRHC@201174|Actinobacteria,4DV0A@85009|Propionibacteriales	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
TLS2_k127_3830486_9	1210045.ALNP01000002_gene4097	7.24e-40	157.0	COG3266@1|root,COG3266@2|Bacteria,2GKZP@201174|Actinobacteria	201174|Actinobacteria	S	Transmembrane domain of unknown function (DUF3566)	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF3566
TLS2_k127_3830486_11	1463857.JOFZ01000008_gene495	8.987e-10	62.0	299R2@1|root,2ZWTA@2|Bacteria,2GQXP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3830486_8	1304865.JAGF01000001_gene928	5.343e-47	176.0	COG0350@1|root,COG0350@2|Bacteria,2IHP1@201174|Actinobacteria,4F1IB@85016|Cellulomonadaceae	201174|Actinobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	ada	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
TLS2_k127_3830486_0	1121372.AULK01000003_gene124	5.293e-177	567.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,2GITG@201174|Actinobacteria,4FKKC@85023|Microbacteriaceae	201174|Actinobacteria	FL	AlkA N-terminal domain	alkA	-	3.2.2.21	ko:K01247,ko:K13529	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
TLS2_k127_3830486_4	105422.BBPM01000061_gene4443	4.377e-79	271.0	COG0652@1|root,COG0652@2|Bacteria,2IFUE@201174|Actinobacteria,2NH5D@228398|Streptacidiphilus	201174|Actinobacteria	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	cypB	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
TLS2_k127_3830486_5	711393.AYRX01000012_gene3316	6.805e-69	244.0	COG0705@1|root,COG0705@2|Bacteria,2GJYG@201174|Actinobacteria	201174|Actinobacteria	NU	Rhomboid family	gluP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid,zf-B_box
TLS2_k127_3830486_10	1120950.KB892743_gene3155	1.518e-19	101.0	2E4NY@1|root,31XN3@2|Bacteria,2GX73@201174|Actinobacteria,4DSQV@85009|Propionibacteriales	201174|Actinobacteria	D	Involved in cell division	crgA	-	-	-	-	-	-	-	-	-	-	-	CrgA
TLS2_k127_3830486_7	1386089.N865_16000	1.456e-59	214.0	COG3879@1|root,COG3879@2|Bacteria,2GJ9Y@201174|Actinobacteria,4FFV4@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF881)	-	-	-	-	-	-	-	-	-	-	-	-	DUF881
TLS2_k127_3830486_2	284031.JNXD01000011_gene709	1.293e-100	331.0	COG0512@1|root,COG0512@2|Bacteria,2GJUX@201174|Actinobacteria	201174|Actinobacteria	EH	Glutamine amidotransferase of anthranilate synthase	trpG	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS2_k127_3830486_6	1449976.KALB_5992	1.456e-59	214.0	COG2931@1|root,COG2931@2|Bacteria,2GNFZ@201174|Actinobacteria	201174|Actinobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
TLS2_k127_3830486_1	1151118.KB895783_gene4023	4.187e-128	425.0	COG0381@1|root,COG0381@2|Bacteria,2GJWS@201174|Actinobacteria,1W7IH@1268|Micrococcaceae	201174|Actinobacteria	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	wecB	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
TLS2_k127_3830486_3	365528.KB891220_gene1174	5.584e-84	294.0	COG1215@1|root,COG1215@2|Bacteria,2I5R7@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3
TLS2_k127_387029_0	1120936.KB907208_gene770	2.281e-227	719.0	COG0488@1|root,COG0488@2|Bacteria,2GJ5M@201174|Actinobacteria,4EHBU@85012|Streptosporangiales	201174|Actinobacteria	S	ABC transporter	yjjK	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
TLS2_k127_387029_2	105420.BBPO01000050_gene1738	1.622e-100	336.0	COG1947@1|root,COG1947@2|Bacteria,2GKXD@201174|Actinobacteria,2NG3E@228398|Streptacidiphilus	201174|Actinobacteria	I	GHMP kinases C terminal	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0040007,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_387029_1	1236902.ANAS01000020_gene1769	3.236e-126	411.0	COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria,4EH1C@85012|Streptosporangiales	201174|Actinobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TLS2_k127_3916047_4	1386089.N865_12990	1.749e-48	185.0	COG3945@1|root,COG3945@2|Bacteria,2GQQY@201174|Actinobacteria	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS2_k127_3916047_5	2002.JOEQ01000005_gene3461	4.393e-43	168.0	COG0317@1|root,COG0317@2|Bacteria,2GNRE@201174|Actinobacteria,4EIIG@85012|Streptosporangiales	201174|Actinobacteria	KT	Amino acid-binding act domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
TLS2_k127_3916047_1	1385520.N802_04265	1.8e-227	752.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,4FJH5@85021|Intrasporangiaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
TLS2_k127_3916047_2	1121924.ATWH01000002_gene3774	1.143e-188	604.0	COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria,4FQMK@85023|Microbacteriaceae	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,cNMP_binding
TLS2_k127_3916047_0	1121946.AUAX01000005_gene5377	4.711e-283	881.0	COG0520@1|root,COG0520@2|Bacteria,2GP7W@201174|Actinobacteria,4DAKS@85008|Micromonosporales	201174|Actinobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_3916047_3	1306174.JODP01000015_gene3953	4.912e-117	386.0	COG4850@1|root,COG4850@2|Bacteria,2GKPS@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2183)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2183
TLS2_k127_399174_6	479435.Kfla_3598	4.481e-41	156.0	COG3030@1|root,COG3030@2|Bacteria,2IA8V@201174|Actinobacteria,4DR8M@85009|Propionibacteriales	201174|Actinobacteria	S	FxsA cytoplasmic membrane protein	-	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
TLS2_k127_399174_3	1449355.JQNR01000005_gene5330	2.396e-111	365.0	COG1216@1|root,COG1216@2|Bacteria,2I2FA@201174|Actinobacteria	201174|Actinobacteria	H	PFAM Glycosyl transferase family 2	ppm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
TLS2_k127_399174_1	1380393.JHVP01000004_gene335	1.624e-155	512.0	COG0815@1|root,COG0815@2|Bacteria,2GJ9F@201174|Actinobacteria,4ERH9@85013|Frankiales	201174|Actinobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
TLS2_k127_399174_4	1385518.N798_12505	5.356e-52	189.0	COG1607@1|root,COG1607@2|Bacteria,2IKM2@201174|Actinobacteria,4FGJW@85021|Intrasporangiaceae	201174|Actinobacteria	I	3-aminobutyryl-CoA ammonia lyase	-	-	4.3.1.14	ko:K18014	ko00310,map00310	-	R03030	RC00833	ko00000,ko00001,ko01000	-	-	-	4HBT
TLS2_k127_399174_2	263358.VAB18032_20385	8.193e-123	414.0	COG2185@1|root,COG2185@2|Bacteria,2HF50@201174|Actinobacteria,4DA5D@85008|Micromonosporales	201174|Actinobacteria	I	Dimerisation domain of d-ornithine 4,5-aminomutase	kamE	-	5.4.3.3	ko:K18011	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,OAM_dimer
TLS2_k127_399174_0	1120950.KB892708_gene4481	1.056e-278	872.0	COG0274@1|root,COG0274@2|Bacteria,2GUM7@201174|Actinobacteria,4DNH2@85009|Propionibacteriales	201174|Actinobacteria	F	D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit	-	-	5.4.3.3	ko:K01844	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	Lys-AminoMut_A
TLS2_k127_399174_5	935866.JAER01000012_gene3538	2.12e-46	172.0	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria,4DT7N@85009|Propionibacteriales	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_4024545_8	2045.KR76_20015	7.348e-36	144.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4DPPG@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS2_k127_4024545_9	1120950.KB892759_gene6230	1.004e-15	79.0	2DSSU@1|root,33HAR@2|Bacteria,2GWP2@201174|Actinobacteria,4DSRX@85009|Propionibacteriales	201174|Actinobacteria	S	Acyl-CoA carboxylase epsilon subunit	-	-	-	-	-	-	-	-	-	-	-	-	ACC_epsilon
TLS2_k127_4024545_1	1122138.AQUZ01000060_gene3886	3.946e-287	888.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4DNBQ@85009|Propionibacteriales	201174|Actinobacteria	I	Carboxyl transferase domain	pccB	GO:0003674,GO:0003824,GO:0003989,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009317,GO:0009987,GO:0015977,GO:0016020,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0030312,GO:0032787,GO:0032991,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:1901575,GO:1902494	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_4024545_0	1120950.KB892759_gene6232	0.0	1208.0	COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria,4DN9B@85009|Propionibacteriales	201174|Actinobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
TLS2_k127_4024545_5	1120950.KB892759_gene6234	7.124e-64	243.0	COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria,4DQT5@85009|Propionibacteriales	201174|Actinobacteria	H	Biotin/lipoate A/B protein ligase family	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
TLS2_k127_4024545_7	1122997.AUDD01000007_gene900	8.153e-37	154.0	COG3428@1|root,COG3428@2|Bacteria,2GK6Y@201174|Actinobacteria,4DRJ7@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
TLS2_k127_4024545_4	196162.Noca_3492	4.959e-73	271.0	COG2114@1|root,COG2114@2|Bacteria,2GN02@201174|Actinobacteria,4DPH6@85009|Propionibacteriales	201174|Actinobacteria	T	Adenylate cyclase regulatory domain	cyaA	GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005504,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009268,GO:0009628,GO:0009975,GO:0009987,GO:0010851,GO:0010854,GO:0010855,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0023052,GO:0030145,GO:0030234,GO:0031279,GO:0031406,GO:0033293,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098772,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1264	Ad_Cy_reg,Guanylate_cyc
TLS2_k127_4024545_3	1944.JOAZ01000017_gene3396	3.757e-112	371.0	COG1024@1|root,COG1024@2|Bacteria,2I2PC@201174|Actinobacteria,418EJ@629295|Streptomyces griseus group	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	yngF	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_4024545_6	479435.Kfla_1447	1.489e-43	172.0	COG2246@1|root,COG2246@2|Bacteria,2IFFV@201174|Actinobacteria,4DRHR@85009|Propionibacteriales	201174|Actinobacteria	S	PFAM GtrA family protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
TLS2_k127_4024545_2	55952.BU52_30115	1.677e-142	462.0	COG0026@1|root,COG0026@2|Bacteria,2GJCU@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
TLS2_k127_4030913_1	743718.Isova_1829	1.263e-272	844.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4F3NG@85017|Promicromonosporaceae	201174|Actinobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS2_k127_4030913_6	1120950.KB892707_gene4796	1.243e-52	190.0	2D9MJ@1|root,32TTI@2|Bacteria,2IFFM@201174|Actinobacteria,4DQZG@85009|Propionibacteriales	201174|Actinobacteria	C	Belongs to the cytochrome c oxidase bacterial subunit CtaF family	ctaF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Cyt_c_ox_IV
TLS2_k127_4030913_2	2074.JNYD01000015_gene4499	1.373e-130	433.0	COG0308@1|root,COG0308@2|Bacteria,2IAPJ@201174|Actinobacteria,4DYC0@85010|Pseudonocardiales	201174|Actinobacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Peptidase_M1,Peptidase_M6
TLS2_k127_4030913_7	1896.JOAU01000046_gene2316	1.621e-41	168.0	COG2091@1|root,COG2091@2|Bacteria,2IQ65@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the P-Pant transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_4030913_3	35754.JNYJ01000033_gene2658	1.215e-80	276.0	COG4285@1|root,COG4285@2|Bacteria,2GNQ0@201174|Actinobacteria,4D9KT@85008|Micromonosporales	201174|Actinobacteria	S	Biotin-protein ligase, N terminal	-	-	-	-	-	-	-	-	-	-	-	-	BPL_N
TLS2_k127_4030913_4	136273.GY22_04175	8.125e-76	274.0	COG3503@1|root,COG3503@2|Bacteria,2I2JM@201174|Actinobacteria,1W8E6@1268|Micrococcaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF418
TLS2_k127_4030913_0	1089455.MOPEL_132_00380	0.0	1454.0	COG0110@1|root,COG1020@1|root,COG0110@2|Bacteria,COG1020@2|Bacteria,2I8TI@201174|Actinobacteria,4F7NP@85018|Dermatophilaceae	201174|Actinobacteria	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Hexapep,Hexapep_2,PP-binding
TLS2_k127_4030913_5	2074.JNYD01000015_gene4498	1.891e-70	251.0	COG3503@1|root,COG3503@2|Bacteria,2I2JM@201174|Actinobacteria,4E008@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF418
TLS2_k127_4037242_22	1380390.JIAT01000009_gene1877	1.205e-11	67.0	COG2208@1|root,COG2208@2|Bacteria,2GNAF@201174|Actinobacteria,4CR74@84995|Rubrobacteria	84995|Rubrobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,SpoIIE
TLS2_k127_4037242_9	593907.Celgi_2014	3.277e-127	426.0	COG4251@1|root,COG4251@2|Bacteria,2GK25@201174|Actinobacteria,4F0F2@85016|Cellulomonadaceae	201174|Actinobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HAMP,HATPase_c,HisKA
TLS2_k127_4037242_12	471852.Tcur_1124	8.44e-66	233.0	COG0784@1|root,COG0784@2|Bacteria,2IFH8@201174|Actinobacteria,4ER7Q@85012|Streptosporangiales	201174|Actinobacteria	T	cheY-homologous receiver domain	rcp1	-	-	ko:K02485	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg
TLS2_k127_4037242_14	1380347.JNII01000006_gene1801	1.9e-54	203.0	COG3832@1|root,COG3832@2|Bacteria,2IN0A@201174|Actinobacteria,4EVV5@85013|Frankiales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_4037242_0	479431.Namu_1742	4.693e-318	998.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4ERMQ@85013|Frankiales	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS2_k127_4037242_20	1381751.JAJB01000037_gene473	1.602e-19	90.0	COG2608@1|root,COG2608@2|Bacteria,2I1G8@201174|Actinobacteria,4FAHK@85019|Brevibacteriaceae	201174|Actinobacteria	P	Heavy-metal-associated domain	-	-	-	-	-	-	-	-	-	-	-	-	HMA
TLS2_k127_4037242_16	1283283.ATXA01000004_gene4462	5.439e-37	151.0	COG1937@1|root,COG1937@2|Bacteria,2IQAC@201174|Actinobacteria,4ET9B@85013|Frankiales	201174|Actinobacteria	S	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
TLS2_k127_4037242_10	743718.Isova_0854	1.358e-121	401.0	COG0530@1|root,COG0530@2|Bacteria,2GJR3@201174|Actinobacteria,4F5HG@85017|Promicromonosporaceae	201174|Actinobacteria	P	PFAM Sodium calcium exchanger membrane region	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
TLS2_k127_4037242_8	266940.Krad_2810	5.397e-133	437.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_4037242_11	269800.Tfu_0944	1.612e-97	331.0	COG2227@1|root,COG2227@2|Bacteria,2IPID@201174|Actinobacteria	201174|Actinobacteria	H	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
TLS2_k127_4037242_19	391037.Sare_3452	2.071e-21	103.0	COG1320@1|root,COG1320@2|Bacteria	2|Bacteria	P	monovalent cation:proton antiporter activity	mnhG	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
TLS2_k127_4037242_21	526225.Gobs_2932	1.004e-13	77.0	COG2212@1|root,COG2212@2|Bacteria,2H19H@201174|Actinobacteria	201174|Actinobacteria	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
TLS2_k127_4037242_18	65497.JODV01000006_gene954	1.606e-27	120.0	COG1863@1|root,COG1863@2|Bacteria	2|Bacteria	P	multisubunit Na H antiporter MnhE subunit	mrpE	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
TLS2_k127_4037242_6	65497.JODV01000006_gene953	1.371e-147	482.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria,4DXG9@85010|Pseudonocardiales	201174|Actinobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	mnhD	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
TLS2_k127_4037242_17	1211815.CBYP010000029_gene1236	3.844e-30	123.0	COG1006@1|root,COG1006@2|Bacteria,2IR2B@201174|Actinobacteria	201174|Actinobacteria	P	Multisubunit Na H antiporter MnhC subunit	mnhC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
TLS2_k127_4037242_1	65497.JODV01000006_gene951	4.764e-275	873.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,2GIT4@201174|Actinobacteria,4DZ06@85010|Pseudonocardiales	201174|Actinobacteria	CP	NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	mnhB	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,NADHdh,Proton_antipo_M,Proton_antipo_N
TLS2_k127_4037242_4	1032480.MLP_38980	1.075e-160	519.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS2_k127_4037242_7	1385520.N802_13870	3.2e-136	457.0	COG0151@1|root,COG0151@2|Bacteria,2I62N@201174|Actinobacteria,4FE38@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the GarS family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4037242_2	1032480.MLP_00540	1.006e-187	605.0	COG0659@1|root,COG4530@1|root,COG0659@2|Bacteria,COG4530@2|Bacteria,2GJCB@201174|Actinobacteria,4DP1B@85009|Propionibacteriales	201174|Actinobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
TLS2_k127_4037242_13	1283299.AUKG01000001_gene3214	1.518e-63	234.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,2H432@201174|Actinobacteria,4CR80@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_4037242_3	208439.AJAP_18295	3.459e-166	533.0	COG0427@1|root,COG0427@2|Bacteria,2IAMG@201174|Actinobacteria	201174|Actinobacteria	C	acetyl-CoA hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
TLS2_k127_4037242_5	219305.MCAG_00968	6.195e-155	497.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4DCHZ@85008|Micromonosporales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS2_k127_4037242_23	1463903.JOIZ01000015_gene2283	8.817e-10	66.0	COG0739@1|root,COG3023@1|root,COG0739@2|Bacteria,COG3023@2|Bacteria,2IFNV@201174|Actinobacteria	201174|Actinobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,Peptidase_M23
TLS2_k127_4037242_15	263358.VAB18032_24405	1.48e-39	148.0	COG1335@1|root,COG1335@2|Bacteria,2I77A@201174|Actinobacteria,4DCTI@85008|Micromonosporales	201174|Actinobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS2_k127_4043335_2	1463856.JOHY01000039_gene1650	1.654e-79	275.0	COG0697@1|root,COG0697@2|Bacteria,2I198@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_4043335_1	1048339.KB913029_gene2897	3.608e-173	550.0	COG0697@1|root,COG2301@1|root,COG0697@2|Bacteria,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4ESAE@85013|Frankiales	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	mcl1	-	4.1.3.34,5.4.99.63	ko:K01644,ko:K14447	ko00630,ko01120,ko01200,ko02020,map00630,map01120,map01200,map02020	M00373	R00362,R09292	RC00067,RC01118,RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_4043335_0	1343740.M271_13275	6.057e-214	670.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_4043335_3	1151061.CAJY01000001_gene3016	3.089e-21	94.0	2CAW2@1|root,32RS7@2|Bacteria,2IB15@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_405574_0	710687.KI912270_gene1294	1.146e-67	254.0	COG2114@1|root,COG2197@1|root,COG3903@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	GerE,Guanylate_cyc,NB-ARC
TLS2_k127_4057129_6	1122138.AQUZ01000064_gene5375	5.366e-62	228.0	COG1335@1|root,COG1335@2|Bacteria,2I77A@201174|Actinobacteria,4DW0B@85009|Propionibacteriales	201174|Actinobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS2_k127_4057129_1	66874.JOFS01000001_gene897	6.26e-138	455.0	COG0654@1|root,COG0654@2|Bacteria,2GN2W@201174|Actinobacteria	201174|Actinobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS2_k127_4057129_7	1048339.KB913029_gene4735	1.905e-59	223.0	2DMA2@1|root,32B92@2|Bacteria,2IMA7@201174|Actinobacteria,4ET2Q@85013|Frankiales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS2_k127_4057129_2	882082.SaccyDRAFT_4224	1.287e-137	449.0	COG0738@1|root,COG0738@2|Bacteria,2I4C7@201174|Actinobacteria,4EFE9@85010|Pseudonocardiales	201174|Actinobacteria	G	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS2_k127_4057129_4	222534.KB893720_gene837	1.325e-92	316.0	COG1396@1|root,COG1396@2|Bacteria,2IBBU@201174|Actinobacteria	201174|Actinobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
TLS2_k127_4057129_0	710111.FraQA3DRAFT_1948	2.239e-169	548.0	28H9S@1|root,2Z7ME@2|Bacteria,2HZP4@201174|Actinobacteria,4EU66@85013|Frankiales	201174|Actinobacteria	S	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL
TLS2_k127_4057129_3	479431.Namu_1612	9.333e-105	345.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria,4EVC6@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
TLS2_k127_4057129_9	1172188.KB911821_gene1279	2.067e-25	110.0	2EMYX@1|root,33FM2@2|Bacteria,2GZ6D@201174|Actinobacteria,4FJGG@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4057129_5	1121272.KB903283_gene5048	5.571e-65	226.0	COG0748@1|root,COG0748@2|Bacteria,2IP6Y@201174|Actinobacteria,4DERE@85008|Micromonosporales	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS2_k127_4057129_8	929712.KI912613_gene2770	3.638e-40	153.0	COG4292@1|root,COG4292@2|Bacteria,2GJPB@201174|Actinobacteria,4CSJZ@84995|Rubrobacteria	84995|Rubrobacteria	S	Bacterial low temperature requirement A protein (LtrA)	-	-	-	-	-	-	-	-	-	-	-	-	LtrA
TLS2_k127_409276_2	1120949.KB903328_gene8976	1.413e-135	436.0	COG0010@1|root,COG0010@2|Bacteria,2H81I@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS2_k127_409276_5	1122609.AUGT01000004_gene1337	7.839e-52	191.0	COG2764@1|root,COG2764@2|Bacteria,2GMZD@201174|Actinobacteria,4DS7K@85009|Propionibacteriales	201174|Actinobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_409276_7	1122609.AUGT01000004_gene1338	8.884e-10	59.0	COG0789@1|root,COG2764@1|root,COG0789@2|Bacteria,COG2764@2|Bacteria,2HZYN@201174|Actinobacteria,4DUKV@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,MerR_1
TLS2_k127_409276_8	196162.Noca_2756	1e-09	63.0	COG4584@1|root,COG4584@2|Bacteria,2GZ8H@201174|Actinobacteria,4DTBI@85009|Propionibacteriales	201174|Actinobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS2_k127_409276_12	1120949.KB903312_gene594	0.0003457	48.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria	201174|Actinobacteria	L	Transposase IS116 IS110 IS902	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_409276_10	196162.Noca_2757	4.909e-07	56.0	COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria,4DS5V@85009|Propionibacteriales	201174|Actinobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
TLS2_k127_409276_6	436229.JOEH01000007_gene4007	8.932e-48	175.0	2E4HJ@1|root,32ZCP@2|Bacteria,2IIYC@201174|Actinobacteria,2NN4A@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_409276_11	1132441.KI519454_gene1071	2.613e-06	56.0	COG0346@1|root,COG0346@2|Bacteria,2IHU2@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_409276_9	1312959.KI914640_gene1351	1.966e-09	58.0	COG0346@1|root,COG0346@2|Bacteria,2IHU2@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_409276_3	1123024.AUII01000046_gene3925	2.835e-108	369.0	COG2181@1|root,COG2181@2|Bacteria,2GJVI@201174|Actinobacteria,4E0F4@85010|Pseudonocardiales	201174|Actinobacteria	C	Nitrate reductase gamma subunit	narI	GO:0001666,GO:0006950,GO:0008150,GO:0009628,GO:0036293,GO:0050896,GO:0070482	1.7.5.1	ko:K00370,ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	iNJ661.Rv1164	Nitrate_red_gam
TLS2_k127_409276_4	479431.Namu_3673	4.093e-59	231.0	COG2180@1|root,COG2180@2|Bacteria,2IAQV@201174|Actinobacteria,4ESU6@85013|Frankiales	201174|Actinobacteria	C	Nitrate reductase, delta subunit	narJ	-	-	ko:K00373	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Nitrate_red_del
TLS2_k127_409276_1	1127134.NOCYR_2942	1.053e-289	932.0	COG1140@1|root,COG1140@2|Bacteria,2GJ8P@201174|Actinobacteria,4FUZU@85025|Nocardiaceae	201174|Actinobacteria	C	Nitrate reductase beta subunit	narH	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
TLS2_k127_409276_0	479431.Namu_3675	0.0	1194.0	COG5013@1|root,COG5013@2|Bacteria,2GKZU@201174|Actinobacteria,4ERXX@85013|Frankiales	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narG	GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008940,GO:0009056,GO:0009628,GO:0009987,GO:0010035,GO:0010167,GO:0016020,GO:0016491,GO:0016661,GO:0030312,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036293,GO:0036294,GO:0042126,GO:0042128,GO:0042221,GO:0042493,GO:0043436,GO:0043602,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070482,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071453,GO:0071704,GO:0071731,GO:0071732,GO:0071941,GO:0071944,GO:0097366,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:2001057	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding
TLS2_k127_4160471_9	1306174.JODP01000006_gene3620	1.613e-48	177.0	COG0234@1|root,COG0234@2|Bacteria,2IKTH@201174|Actinobacteria	201174|Actinobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TLS2_k127_4160471_11	479435.Kfla_6032	1.657e-38	160.0	COG0742@1|root,COG0742@2|Bacteria,2I6DB@201174|Actinobacteria,4DWFG@85009|Propionibacteriales	201174|Actinobacteria	L	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_4160471_14	882086.SacxiDRAFT_3338	2.131e-08	60.0	COG0116@1|root,COG0116@2|Bacteria,2I2N1@201174|Actinobacteria,4DZAK@85010|Pseudonocardiales	201174|Actinobacteria	L	SAM-dependent	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4160471_2	1120950.KB892784_gene208	2.024e-166	539.0	COG1472@1|root,COG1472@2|Bacteria,2GM43@201174|Actinobacteria,4DTSU@85009|Propionibacteriales	201174|Actinobacteria	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
TLS2_k127_4160471_13	330084.JNYZ01000010_gene6834	3.015e-23	116.0	COG1957@1|root,COG1957@2|Bacteria,2GP6N@201174|Actinobacteria,4E1GE@85010|Pseudonocardiales	201174|Actinobacteria	F	Inosine-uridine preferring nucleoside hydrolase	-	-	3.2.2.1,3.2.2.8	ko:K01239,ko:K01250,ko:K10213,ko:K12700	ko00230,ko00240,ko00760,ko01100,map00230,map00240,map00760,map01100	-	R01245,R01273,R01677,R01770,R02137,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
TLS2_k127_4160471_1	196162.Noca_3657	1.577e-169	553.0	COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria,4DP6P@85009|Propionibacteriales	201174|Actinobacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
TLS2_k127_4160471_12	100226.SCO4751	5.582e-35	153.0	COG0454@1|root,COG0456@2|Bacteria,2IM9R@201174|Actinobacteria	201174|Actinobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TLS2_k127_4160471_6	1120950.KB892784_gene197	2.874e-61	218.0	COG1214@1|root,COG1214@2|Bacteria,2GMTM@201174|Actinobacteria,4DQ98@85009|Propionibacteriales	201174|Actinobacteria	O	Glycoprotease family	yeaZ	GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
TLS2_k127_4160471_8	1223523.H340_25272	1.672e-51	199.0	COG0802@1|root,COG0802@2|Bacteria,2IKV2@201174|Actinobacteria	201174|Actinobacteria	K	ATPase or kinase	tsaE	GO:0008150,GO:0040007	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
TLS2_k127_4160471_7	1380356.JNIK01000018_gene599	3.8e-54	212.0	COG1573@1|root,COG1573@2|Bacteria,2GMPT@201174|Actinobacteria,4EVJB@85013|Frankiales	201174|Actinobacteria	L	Uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_4160471_5	1120950.KB892784_gene194	1.89e-111	387.0	COG2267@1|root,COG2267@2|Bacteria,2GMCK@201174|Actinobacteria,4DNK4@85009|Propionibacteriales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
TLS2_k127_4160471_4	365528.KB891252_gene5557	6.781e-145	483.0	COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4ERH5@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TLS2_k127_4160471_3	1120950.KB892784_gene190	8.777e-152	496.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2GJHB@201174|Actinobacteria,4DN6W@85009|Propionibacteriales	201174|Actinobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
TLS2_k127_4160471_10	1120950.KB892784_gene189	3.887e-47	175.0	COG0736@1|root,COG0736@2|Bacteria,2IQF6@201174|Actinobacteria,4DRCQ@85009|Propionibacteriales	201174|Actinobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_4160471_0	105420.BBPO01000022_gene5761	1.081e-242	754.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,2NFT8@228398|Streptacidiphilus	201174|Actinobacteria	M	Glutamine amidotransferase domain	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iNJ661.Rv3436c	GATase_6,SIS
TLS2_k127_419006_16	1179773.BN6_72260	9.149e-34	133.0	COG0454@1|root,COG0456@2|Bacteria,2IQC7@201174|Actinobacteria,4E3GV@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_419006_17	1120950.KB892749_gene3314	4.508e-31	139.0	COG5496@1|root,COG5496@2|Bacteria,2IKZP@201174|Actinobacteria,4DRX7@85009|Propionibacteriales	201174|Actinobacteria	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_419006_19	1120950.KB892749_gene3315	5.573e-20	94.0	COG4770@1|root,COG4770@2|Bacteria,2I2DF@201174|Actinobacteria,4DSRA@85009|Propionibacteriales	201174|Actinobacteria	I	Biotin-requiring enzyme	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
TLS2_k127_419006_20	1122138.AQUZ01000025_gene2793	0.0001457	54.0	2DRIE@1|root,33BXS@2|Bacteria,2GYYF@201174|Actinobacteria	201174|Actinobacteria	S	Family of unknown function (DUF5317)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5317
TLS2_k127_419006_18	479435.Kfla_5215	1.58e-25	108.0	COG5662@1|root,COG5662@2|Bacteria,2IM2X@201174|Actinobacteria,4DS64@85009|Propionibacteriales	201174|Actinobacteria	K	Putative zinc-finger	rsrA	GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_419006_6	471852.Tcur_3708	9.591e-103	339.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4EHPQ@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70, region 4	sigH	GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_419006_10	1463857.JOFZ01000002_gene4871	2.232e-69	241.0	COG3571@1|root,COG3571@2|Bacteria,2GKKE@201174|Actinobacteria	201174|Actinobacteria	S	Hydrolase of the alpha beta-hydrolase	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	DLH
TLS2_k127_419006_7	1120950.KB892749_gene3321	2.84e-99	334.0	COG2135@1|root,COG2135@2|Bacteria,2GKY8@201174|Actinobacteria,4DPFJ@85009|Propionibacteriales	201174|Actinobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
TLS2_k127_419006_13	1122609.AUGT01000021_gene1179	5.774e-43	163.0	COG2259@1|root,COG2259@2|Bacteria,2HD6Y@201174|Actinobacteria,4DR14@85009|Propionibacteriales	201174|Actinobacteria	ADL	DoxX	doxX	-	-	-	-	-	-	-	-	-	-	-	DoxX
TLS2_k127_419006_3	58123.JOFJ01000003_gene2271	7.988e-174	555.0	COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria,4EHSM@85012|Streptosporangiales	201174|Actinobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TLS2_k127_419006_4	1120950.KB892749_gene3327	2.46e-137	452.0	COG1162@1|root,COG1162@2|Bacteria,2GJ37@201174|Actinobacteria,4DNJ3@85009|Propionibacteriales	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
TLS2_k127_419006_5	196162.Noca_1697	1.609e-111	377.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4DNRF@85009|Propionibacteriales	201174|Actinobacteria	G	Inositol monophosphatase family	hisN	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS2_k127_419006_12	697282.Mettu_1861	8.949e-47	184.0	2CCJR@1|root,2ZCU4@2|Bacteria,1RC7F@1224|Proteobacteria,1S3JC@1236|Gammaproteobacteria,1XDT3@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_419006_9	235985.BBPN01000002_gene5002	5.972e-87	302.0	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,2NGIT@228398|Streptacidiphilus	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_419006_1	935839.JAGJ01000007_gene3184	4.778e-234	750.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,4F39B@85017|Promicromonosporaceae	201174|Actinobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD_C_2,Viral_helicase1
TLS2_k127_419006_11	1487953.JMKF01000045_gene2916	2.111e-50	194.0	COG0382@1|root,COG0382@2|Bacteria,1G1UG@1117|Cyanobacteria,1H8PU@1150|Oscillatoriales	1117|Cyanobacteria	H	PFAM UbiA prenyltransferase	-	GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009987,GO:0010189,GO:0018130,GO:0042360,GO:0042362,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617	2.5.1.115,2.5.1.116	ko:K09833	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00112	R07500,R10708	RC01840,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iJN678.slr1736	UbiA
TLS2_k127_419006_8	479434.Sthe_3382	1.493e-92	323.0	COG2271@1|root,COG2271@2|Bacteria,2G6NQ@200795|Chloroflexi,27XGJ@189775|Thermomicrobia	189775|Thermomicrobia	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_419006_2	1386089.N865_02385	4.473e-176	564.0	COG2072@1|root,COG2072@2|Bacteria,2GKBD@201174|Actinobacteria,4FFQW@85021|Intrasporangiaceae	201174|Actinobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_3
TLS2_k127_419006_14	1120950.KB892744_gene2822	1.817e-42	158.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria,4DRUV@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
TLS2_k127_419006_0	1123024.AUII01000015_gene3749	8.361e-256	809.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Abhydrolase_1,GerE,Trans_reg_C
TLS2_k127_4193347_3	1297865.APJD01000018_gene5739	6.709e-55	201.0	COG2334@1|root,COG2334@2|Bacteria,1R27Y@1224|Proteobacteria,2UK4N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_4193347_4	1122182.KB903837_gene3716	2.793e-19	90.0	COG3173@1|root,COG3173@2|Bacteria,2I2V8@201174|Actinobacteria,4DAC1@85008|Micromonosporales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_4193347_0	1033730.CAHG01000008_gene3234	1.338e-205	659.0	COG0215@1|root,COG0215@2|Bacteria,2GJF2@201174|Actinobacteria,4DP8C@85009|Propionibacteriales	201174|Actinobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
TLS2_k127_4193347_2	1449353.JQMQ01000005_gene2749	3.031e-119	391.0	COG0566@1|root,COG0566@2|Bacteria,2GJMR@201174|Actinobacteria,2NHWX@228398|Streptacidiphilus	201174|Actinobacteria	J	RNA 2'-O ribose methyltransferase substrate binding	rlmB	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS2_k127_4193347_1	103733.JNYO01000023_gene7076	4.284e-164	524.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4DXHT@85010|Pseudonocardiales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_4194430_2	1120950.KB892801_gene1716	3.292e-91	304.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4DP9B@85009|Propionibacteriales	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TLS2_k127_4194430_3	743718.Isova_2655	5.307e-90	308.0	COG0302@1|root,COG0302@2|Bacteria,2GP2P@201174|Actinobacteria,4F3XW@85017|Promicromonosporaceae	201174|Actinobacteria	H	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3609c	GTP_cyclohydroI
TLS2_k127_4194430_0	479435.Kfla_6465	8.667e-114	374.0	COG0294@1|root,COG0294@2|Bacteria,2GJDQ@201174|Actinobacteria,4DPQM@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TLS2_k127_4194430_6	1122138.AQUZ01000014_gene7011	1.727e-45	171.0	COG4319@1|root,COG4319@2|Bacteria,2GNV0@201174|Actinobacteria,4DVQ0@85009|Propionibacteriales	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
TLS2_k127_4194430_8	1380393.JHVP01000001_gene2049	2.335e-05	56.0	COG3599@1|root,COG3599@2|Bacteria,2IHMW@201174|Actinobacteria,4EWXA@85013|Frankiales	201174|Actinobacteria	D	regulation of cell shape	-	-	-	-	-	-	-	-	-	-	-	-	DivIVA
TLS2_k127_4194430_5	68570.DC74_4570	3.952e-46	169.0	COG1539@1|root,COG1539@2|Bacteria,2IHSW@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	GO:0008150,GO:0040007	1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8	ko:K01633,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00840	R03503,R03504,R11037,R11073	RC00002,RC00017,RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
TLS2_k127_4194430_4	1120950.KB892801_gene1722	3.971e-61	222.0	COG0801@1|root,COG0801@2|Bacteria,2H3G6@201174|Actinobacteria,4DQ88@85009|Propionibacteriales	201174|Actinobacteria	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
TLS2_k127_4194430_1	1123320.KB889585_gene1788	1.473e-99	330.0	COG1125@1|root,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	opuCA	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran
TLS2_k127_4204121_10	477641.MODMU_1206	4.951e-102	338.0	COG1075@1|root,COG1075@2|Bacteria,2I9FH@201174|Actinobacteria	201174|Actinobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	DUF900,PGAP1
TLS2_k127_4204121_20	1151119.KB895491_gene1868	8.672e-32	129.0	2DRYE@1|root,33DPC@2|Bacteria,2IS24@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4204121_23	1394178.AWOO02000006_gene3308	3.588e-23	113.0	COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria,4EKMK@85012|Streptosporangiales	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
TLS2_k127_4204121_7	269800.Tfu_2255	1.458e-122	412.0	COG4262@1|root,COG4262@2|Bacteria,2I372@201174|Actinobacteria	201174|Actinobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
TLS2_k127_4204121_26	2045.KR76_07990	2.074e-10	66.0	COG0584@1|root,COG0584@2|Bacteria,2GM8K@201174|Actinobacteria,4DNYK@85009|Propionibacteriales	201174|Actinobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD,Phytase-like
TLS2_k127_4204121_22	644283.Micau_5604	1.699e-27	126.0	COG0584@1|root,COG0584@2|Bacteria,2GM8K@201174|Actinobacteria,4D9WB@85008|Micromonosporales	201174|Actinobacteria	C	Glycerophosphoryl diester phosphodiesterase family	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD,Phytase-like
TLS2_k127_4204121_24	882086.SacxiDRAFT_2239	6.264e-23	104.0	COG0584@1|root,COG0584@2|Bacteria,2GM8K@201174|Actinobacteria,4DX6D@85010|Pseudonocardiales	201174|Actinobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS2_k127_4204121_28	33876.JNXY01000050_gene5499	0.0009972	45.0	29MCR@1|root,308AJ@2|Bacteria,2GU2S@201174|Actinobacteria,4DFWC@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4204121_15	1120950.KB892783_gene322	1.082e-63	239.0	COG1983@1|root,COG1983@2|Bacteria,2GIVS@201174|Actinobacteria,4DS1M@85009|Propionibacteriales	201174|Actinobacteria	KT	PspC domain	pspC	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
TLS2_k127_4204121_8	1120950.KB892783_gene321	5.561e-119	404.0	COG1983@1|root,COG4585@1|root,COG1983@2|Bacteria,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4DNII@85009|Propionibacteriales	201174|Actinobacteria	T	PspC domain	tcsS3	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,PspC
TLS2_k127_4204121_11	479435.Kfla_1239	7.47e-102	338.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4DQ1R@85009|Propionibacteriales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	tcsR3	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_4204121_19	1304865.JAGF01000001_gene590	5.455e-32	130.0	2E4PN@1|root,32ZIA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4204121_0	469371.Tbis_0652	1.35e-311	972.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4DZQT@85010|Pseudonocardiales	201174|Actinobacteria	L	ATP-dependent DNA helicase	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS2_k127_4204121_16	196162.Noca_3774	4.172e-44	171.0	COG0739@1|root,COG0739@2|Bacteria,2GM7Q@201174|Actinobacteria,4DWK4@85009|Propionibacteriales	201174|Actinobacteria	M	Peptidase family M23	mepA	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
TLS2_k127_4204121_9	367299.JOEE01000007_gene68	2.332e-104	349.0	COG1075@1|root,COG1075@2|Bacteria,2GMZA@201174|Actinobacteria,4FFRU@85021|Intrasporangiaceae	201174|Actinobacteria	S	with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,DUF676,PGAP1
TLS2_k127_4204121_13	479435.Kfla_1266	9.283e-68	234.0	COG2185@1|root,COG2185@2|Bacteria,2IFJD@201174|Actinobacteria,4DQPH@85009|Propionibacteriales	201174|Actinobacteria	I	PFAM cobalamin B12-binding domain protein	icmB	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
TLS2_k127_4204121_2	330084.JNYZ01000040_gene4958	1.813e-176	560.0	COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria,4E03D@85010|Pseudonocardiales	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
TLS2_k127_4204121_4	1122622.ATWJ01000007_gene1578	6.03e-154	489.0	COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria,4FFWQ@85021|Intrasporangiaceae	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
TLS2_k127_4204121_21	479435.Kfla_0958	6.312e-31	136.0	COG1714@1|root,COG1714@2|Bacteria,2HGSH@201174|Actinobacteria,4DSGU@85009|Propionibacteriales	201174|Actinobacteria	S	RDD family	pra	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	RDD
TLS2_k127_4204121_5	397278.JOJN01000007_gene3340	5.115e-141	459.0	COG3844@1|root,COG3844@2|Bacteria,2GMJQ@201174|Actinobacteria,4DQD1@85009|Propionibacteriales	201174|Actinobacteria	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
TLS2_k127_4204121_14	1120950.KB892760_gene5720	8.603e-67	251.0	COG1595@1|root,COG1595@2|Bacteria,2GKDD@201174|Actinobacteria,4DREX@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4204121_18	1120950.KB892760_gene5721	1.267e-38	166.0	COG2311@1|root,COG2311@2|Bacteria,2GKA8@201174|Actinobacteria,4DQSU@85009|Propionibacteriales	201174|Actinobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4204121_27	1120950.KB892760_gene5722	0.0005883	50.0	2DDN7@1|root,2ZIN3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
TLS2_k127_4204121_12	471852.Tcur_4216	7.979e-81	277.0	COG0299@1|root,COG0299@2|Bacteria,2H8QB@201174|Actinobacteria,4EITU@85012|Streptosporangiales	201174|Actinobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
TLS2_k127_4204121_1	1120950.KB892760_gene5724	2.54e-242	759.0	COG0138@1|root,COG0138@2|Bacteria,2GJWU@201174|Actinobacteria,4DP1R@85009|Propionibacteriales	201174|Actinobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
TLS2_k127_4204121_17	713586.KB900536_gene328	1.077e-39	171.0	COG2133@1|root,COG2133@2|Bacteria,1QWB2@1224|Proteobacteria	1224|Proteobacteria	G	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
TLS2_k127_4204121_6	269800.Tfu_2571	7.997e-128	428.0	COG0190@1|root,COG0190@2|Bacteria,2GJZS@201174|Actinobacteria,4EH3U@85012|Streptosporangiales	201174|Actinobacteria	H	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
TLS2_k127_4204121_3	1122611.KB903961_gene4370	3.034e-165	527.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4EI8G@85012|Streptosporangiales	201174|Actinobacteria	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS2_k127_420658_4	1206732.BAGD01000027_gene711	7.955e-32	133.0	COG3427@1|root,COG3427@2|Bacteria,2IRE2@201174|Actinobacteria,4G3AE@85025|Nocardiaceae	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_420658_2	479435.Kfla_4635	1.393e-114	380.0	COG1506@1|root,COG1506@2|Bacteria,2I577@201174|Actinobacteria,4DPZX@85009|Propionibacteriales	201174|Actinobacteria	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
TLS2_k127_420658_1	66377.JOBH01000020_gene4267	3.89e-177	573.0	COG0179@1|root,COG0179@2|Bacteria,2GNGC@201174|Actinobacteria	201174|Actinobacteria	Q	Fumarylacetoacetase	-	-	3.7.1.2	ko:K01555	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FAA_hydrolase,FAA_hydrolase_N
TLS2_k127_420658_3	1120950.KB892751_gene6798	3.32e-65	237.0	COG0124@1|root,COG0124@2|Bacteria,2GJXW@201174|Actinobacteria,4DQBI@85009|Propionibacteriales	201174|Actinobacteria	J	histidyl-tRNA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_420658_0	405948.SACE_3944	2.794e-233	726.0	COG3508@1|root,COG3508@2|Bacteria,2GKZV@201174|Actinobacteria,4DXK4@85010|Pseudonocardiales	201174|Actinobacteria	Q	homogentisate 12-dioxygenase	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
TLS2_k127_4217178_2	1193181.BN10_940010	5.341e-96	319.0	COG0740@1|root,COG0740@2|Bacteria,2GK5C@201174|Actinobacteria,4FEPP@85021|Intrasporangiaceae	201174|Actinobacteria	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP1	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TLS2_k127_4217178_1	479435.Kfla_2282	4.545e-139	459.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,4DP8U@85009|Propionibacteriales	201174|Actinobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
TLS2_k127_4217178_0	1123319.AUBE01000027_gene4804	6.46e-155	504.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_4232030_2	1120950.KB892747_gene3666	7.137e-118	394.0	COG1351@1|root,COG1351@2|Bacteria,2HCNJ@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	GO:0000166,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0036094,GO:0040007,GO:0042083,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050797,GO:0070402,GO:0097159,GO:1901265,GO:1901363	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	iNJ661.Rv2754c	Thy1
TLS2_k127_4232030_1	479435.Kfla_2974	8.222e-146	470.0	COG1018@1|root,COG1018@2|Bacteria,2GKGS@201174|Actinobacteria,4DNQQ@85009|Propionibacteriales	201174|Actinobacteria	C	Oxidoreductase FAD-binding domain	paaK	-	-	ko:K02613	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
TLS2_k127_4232030_4	979556.MTES_2791	4.071e-61	221.0	COG2151@1|root,COG2151@2|Bacteria,2II4H@201174|Actinobacteria,4FNUZ@85023|Microbacteriaceae	201174|Actinobacteria	S	Iron-sulfur cluster assembly protein	paaJ	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
TLS2_k127_4232030_3	479433.Caci_1746	8.461e-106	354.0	COG3396@1|root,COG3396@2|Bacteria,2GJIU@201174|Actinobacteria	201174|Actinobacteria	S	Phenylacetate-CoA oxygenase, PaaI subunit	paaI	-	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
TLS2_k127_4232030_6	287986.DV20_21610	5.017e-46	183.0	COG3460@1|root,COG3460@2|Bacteria,2IKMJ@201174|Actinobacteria,4E4A8@85010|Pseudonocardiales	201174|Actinobacteria	Q	PFAM Phenylacetic acid degradation B	paaB	-	-	ko:K02610	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	PaaB
TLS2_k127_4232030_0	35754.JNYJ01000036_gene3803	7.436e-169	540.0	COG3396@1|root,COG3396@2|Bacteria,2GMQ3@201174|Actinobacteria,4D8NM@85008|Micromonosporales	201174|Actinobacteria	S	phenylacetate-CoA oxygenase	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
TLS2_k127_4232030_7	561175.KB894094_gene1715	5.427e-40	155.0	COG5516@1|root,COG5516@2|Bacteria,2IFNZ@201174|Actinobacteria,4EJZA@85012|Streptosporangiales	201174|Actinobacteria	S	CGNR zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
TLS2_k127_4232030_5	1120950.KB892747_gene3676	1.098e-56	207.0	COG0454@1|root,COG0456@2|Bacteria,2I2XB@201174|Actinobacteria,4DQWV@85009|Propionibacteriales	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_4234963_2	66897.DJ64_02855	2.954e-91	307.0	COG2378@1|root,COG2378@2|Bacteria,2GURQ@201174|Actinobacteria	201174|Actinobacteria	K	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
TLS2_k127_4234963_4	469383.Cwoe_0891	2.044e-59	213.0	COG0671@1|root,COG0671@2|Bacteria,2IIA1@201174|Actinobacteria,4CQUT@84995|Rubrobacteria	84995|Rubrobacteria	I	PFAM phosphoesterase, PA-phosphatase related	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
TLS2_k127_4234963_0	469383.Cwoe_0890	5.39e-135	442.0	COG1597@1|root,COG1597@2|Bacteria,2GNNM@201174|Actinobacteria	201174|Actinobacteria	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS2_k127_4234963_1	526225.Gobs_0260	1.23e-129	422.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4234963_3	414996.IL38_00840	1.338e-90	319.0	COG0842@1|root,COG0842@2|Bacteria,2GP9E@201174|Actinobacteria,408CR@622450|Actinopolysporales	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_42397_16	391037.Sare_3917	6.981e-30	118.0	COG0488@1|root,COG0488@2|Bacteria,2GKBQ@201174|Actinobacteria,4D9H1@85008|Micromonosporales	201174|Actinobacteria	S	ABC transporter	yjjK	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
TLS2_k127_42397_11	1380393.JHVP01000018_gene120	7.008e-55	201.0	COG0586@1|root,COG0586@2|Bacteria,2GN43@201174|Actinobacteria,4EVTV@85013|Frankiales	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_42397_12	67352.JODS01000014_gene5468	5.012e-50	181.0	COG0824@1|root,COG0824@2|Bacteria,2IFAK@201174|Actinobacteria	201174|Actinobacteria	S	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
TLS2_k127_42397_17	1463856.JOHY01000007_gene672	2.663e-29	134.0	COG0824@1|root,COG0824@2|Bacteria,2IFAK@201174|Actinobacteria	201174|Actinobacteria	S	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
TLS2_k127_42397_14	1123320.KB889629_gene7844	8.632e-34	147.0	2DQ1M@1|root,32UNB@2|Bacteria,2GJD1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_42397_0	43354.JOIJ01000008_gene2971	0.0	1038.0	COG2133@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,2GJFY@201174|Actinobacteria,4E1CS@85010|Pseudonocardiales	201174|Actinobacteria	G	glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,DUF1080,GSDH,PKD,Ricin_B_lectin,ThuA
TLS2_k127_42397_6	263358.VAB18032_21550	1.224e-141	458.0	COG1082@1|root,COG1082@2|Bacteria,2HAZQ@201174|Actinobacteria,4DE1P@85008|Micromonosporales	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_42397_2	405948.SACE_4257	6.77e-238	747.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4DX7R@85010|Pseudonocardiales	201174|Actinobacteria	G	PFAM Alpha amylase, catalytic	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
TLS2_k127_42397_3	1120936.KB907217_gene3675	9.406e-228	713.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GNDC@201174|Actinobacteria,4EG2R@85012|Streptosporangiales	201174|Actinobacteria	F	IMP dehydrogenase / GMP reductase domain	guaB1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TLS2_k127_42397_10	446471.Xcel_1098	2.617e-58	215.0	COG2346@1|root,COG2346@2|Bacteria,2IKPF@201174|Actinobacteria,4F4FZ@85017|Promicromonosporaceae	201174|Actinobacteria	S	Bacterial-like globin	glbO	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
TLS2_k127_42397_13	196162.Noca_1377	1.7e-47	195.0	COG1764@1|root,COG1764@2|Bacteria,2IFFB@201174|Actinobacteria,4DRBU@85009|Propionibacteriales	201174|Actinobacteria	O	OsmC-like protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
TLS2_k127_42397_1	479431.Namu_1690	7.663e-282	879.0	COG0366@1|root,COG0366@2|Bacteria,2GKT9@201174|Actinobacteria,4EUYW@85013|Frankiales	201174|Actinobacteria	G	Alpha amylase, catalytic domain	ams	-	2.4.1.4	ko:K05341	ko00500,map00500	-	R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
TLS2_k127_42397_15	477641.MODMU_0614	3.977e-32	134.0	COG1476@1|root,COG1476@2|Bacteria,2IRJP@201174|Actinobacteria,4EW8K@85013|Frankiales	201174|Actinobacteria	K	transcriptional regulator, XRE family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS2_k127_42397_8	477641.MODMU_0615	1.719e-128	431.0	COG0842@1|root,COG0842@2|Bacteria,2HTW2@201174|Actinobacteria,4EV1Z@85013|Frankiales	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_42397_7	477641.MODMU_0616	3.969e-136	441.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4EU54@85013|Frankiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_42397_4	479435.Kfla_3634	1.291e-225	713.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,4DPF9@85009|Propionibacteriales	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
TLS2_k127_42397_18	526225.Gobs_4946	3.625e-21	99.0	2EHFT@1|root,33B7P@2|Bacteria,2GYTG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_42397_9	110319.CF8_1067	2.36e-107	362.0	COG0668@1|root,COG0668@2|Bacteria,2GMFK@201174|Actinobacteria,4DNMY@85009|Propionibacteriales	201174|Actinobacteria	M	mechanosensitive ion channel	mscS	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
TLS2_k127_42397_5	1122611.KB903950_gene6453	4.722e-162	517.0	COG1505@1|root,COG1505@2|Bacteria,2IRXB@201174|Actinobacteria,4EG49@85012|Streptosporangiales	201174|Actinobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
TLS2_k127_424704_1	649831.L083_0018	4.092e-70	247.0	COG2230@1|root,COG2230@2|Bacteria,2GJ94@201174|Actinobacteria,4DA2F@85008|Micromonosporales	201174|Actinobacteria	M	Mycolic acid cyclopropane synthetase	cfa	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS2_k127_424704_0	479435.Kfla_5690	7.741e-197	627.0	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,4DPIA@85009|Propionibacteriales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_4278338_8	1459636.NTE_01130	2.663e-16	87.0	COG0456@1|root,arCOG00833@2157|Archaea	2157|Archaea	C	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
TLS2_k127_4278338_7	404589.Anae109_3157	7.006e-39	148.0	COG0346@1|root,COG0346@2|Bacteria,1NA4J@1224|Proteobacteria	1224|Proteobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_4278338_3	469383.Cwoe_1927	1.289e-99	346.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_4278338_11	1242864.D187_003037	2.981e-05	54.0	COG2273@1|root,COG2273@2|Bacteria,1NFHX@1224|Proteobacteria,43AJK@68525|delta/epsilon subdivisions,2X5ZT@28221|Deltaproteobacteria,2YUVB@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolases family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
TLS2_k127_4278338_0	1035308.AQYY01000002_gene164	4.233e-154	493.0	COG2376@1|root,COG2376@2|Bacteria,1TP92@1239|Firmicutes,2488D@186801|Clostridia	186801|Clostridia	G	Dihydroxyacetone kinase	dhaK	-	2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01059	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Dak1,Dak2
TLS2_k127_4278338_6	1380390.JIAT01000009_gene1630	1.481e-64	227.0	COG1461@1|root,COG1461@2|Bacteria,2IH72@201174|Actinobacteria,4CRQ4@84995|Rubrobacteria	84995|Rubrobacteria	S	Dak2	-	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
TLS2_k127_4278338_4	469383.Cwoe_3124	1.353e-96	325.0	COG0637@1|root,COG0637@2|Bacteria,2GMIQ@201174|Actinobacteria,4CQKP@84995|Rubrobacteria	84995|Rubrobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS2_k127_4278338_2	1416759.AYMR01000009_gene2922	4.275e-109	360.0	COG0191@1|root,COG0191@2|Bacteria,2H640@201174|Actinobacteria,4FR8M@85023|Microbacteriaceae	201174|Actinobacteria	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
TLS2_k127_4278338_5	1286631.X805_00960	8.063e-65	236.0	COG2390@1|root,COG2390@2|Bacteria,1MX3F@1224|Proteobacteria,2VP7U@28216|Betaproteobacteria,1KN1A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Putative sugar-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,Sugar-bind
TLS2_k127_4278338_10	643473.KB235930_gene2771	5.686e-06	53.0	2E9IP@1|root,333RN@2|Bacteria,1GA2A@1117|Cyanobacteria,1HSTB@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4278338_9	441620.Mpop_5334	5.297e-06	53.0	2CCDG@1|root,32RVE@2|Bacteria,1N8P9@1224|Proteobacteria,2UI79@28211|Alphaproteobacteria,1JVA2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4278338_1	1246445.ANAY01000016_gene2221	7.42e-147	466.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4EG2W@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigA	GO:0000988,GO:0000990,GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043254,GO:0044087,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_4292839_1	2002.JOEQ01000030_gene2093	2.044e-56	206.0	COG0518@1|root,COG0518@2|Bacteria,2GNA6@201174|Actinobacteria,4EITR@85012|Streptosporangiales	201174|Actinobacteria	F	Glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
TLS2_k127_4292839_0	1120950.KB892708_gene4503	1.979e-167	539.0	COG0616@1|root,COG0616@2|Bacteria,2HQDG@201174|Actinobacteria,4DNPY@85009|Propionibacteriales	201174|Actinobacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773,ko:K04774	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TLS2_k127_4326193_0	351607.Acel_0801	0.0	1090.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4ERQZ@85013|Frankiales	201174|Actinobacteria	G	pyruvate phosphate dikinase, PEP	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS2_k127_4326193_5	477641.MODMU_1784	1.652e-58	209.0	COG1434@1|root,COG1434@2|Bacteria,2I2NF@201174|Actinobacteria,4ET60@85013|Frankiales	201174|Actinobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
TLS2_k127_4326193_3	1120950.KB892739_gene3945	1.571e-164	530.0	COG0232@1|root,COG0232@2|Bacteria,2GJ8F@201174|Actinobacteria,4DP2K@85009|Propionibacteriales	201174|Actinobacteria	F	Phosphohydrolase-associated domain	dgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
TLS2_k127_4326193_4	479432.Sros_1897	6.761e-159	511.0	COG1251@1|root,COG1251@2|Bacteria,2I3CF@201174|Actinobacteria,4EQYP@85012|Streptosporangiales	201174|Actinobacteria	C	Reductase C-terminal	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
TLS2_k127_4326193_1	1120950.KB892739_gene3932	1.474e-230	729.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4DN6K@85009|Propionibacteriales	201174|Actinobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
TLS2_k127_4326193_2	408672.NBCG_02035	1.03e-181	592.0	COG1940@1|root,COG1940@2|Bacteria,2GJ2S@201174|Actinobacteria,4DN6E@85009|Propionibacteriales	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
TLS2_k127_4326193_6	1114959.SZMC14600_17183	4.042e-55	199.0	COG2133@1|root,COG3291@1|root,COG3828@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG3828@2|Bacteria,2GJFY@201174|Actinobacteria,4E1CS@85010|Pseudonocardiales	201174|Actinobacteria	G	glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,DUF1080,GSDH,PKD,ThuA
TLS2_k127_4328921_2	479431.Namu_5174	7.84e-219	700.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4ESAG@85013|Frankiales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_4328921_0	405948.SACE_2041	1.461e-292	926.0	COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,4E0SI@85010|Pseudonocardiales	201174|Actinobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TLS2_k127_4328921_3	469371.Tbis_2054	2.201e-184	584.0	COG0124@1|root,COG0124@2|Bacteria,2GIYJ@201174|Actinobacteria,4DYW0@85010|Pseudonocardiales	201174|Actinobacteria	J	histidyl-tRNA synthetase	hisS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TLS2_k127_4328921_5	1184609.KILIM_012_00220	8.253e-95	316.0	COG0491@1|root,COG0491@2|Bacteria,2GJU0@201174|Actinobacteria,4F6S3@85018|Dermatophilaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_4328921_6	1123320.KB889665_gene1394	2.992e-53	211.0	COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria	201174|Actinobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
TLS2_k127_4328921_4	479435.Kfla_4393	6.647e-128	433.0	COG1196@1|root,COG1196@2|Bacteria,2GJBD@201174|Actinobacteria,4DNC8@85009|Propionibacteriales	201174|Actinobacteria	D	Domain of Unknown Function (DUF349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF349
TLS2_k127_4328921_1	749414.SBI_02391	3.2e-242	754.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria	201174|Actinobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TLS2_k127_4354216_2	196162.Noca_1667	1.603e-165	529.0	COG3320@1|root,COG3320@2|Bacteria,2I2PV@201174|Actinobacteria	201174|Actinobacteria	IQ	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4
TLS2_k127_4354216_0	196162.Noca_1668	0.0	1071.0	COG5322@1|root,COG5322@2|Bacteria,2IEVX@201174|Actinobacteria	201174|Actinobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Semialdhyde_dh,Shikimate_DH
TLS2_k127_4354216_1	330084.JNYZ01000002_gene1656	6.271e-179	591.0	COG1520@1|root,COG3391@1|root,COG1520@2|Bacteria,COG3391@2|Bacteria,2H069@201174|Actinobacteria,4DZ5C@85010|Pseudonocardiales	201174|Actinobacteria	S	Tachylectin	-	-	3.5.1.56	ko:K03418	ko00630,map00630	-	R02509	RC00111,RC00731	ko00000,ko00001,ko01000	-	-	-	Tachylectin
TLS2_k127_4354216_3	1463854.JOHT01000009_gene1661	5.409e-160	516.0	COG3004@1|root,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria	201174|Actinobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
TLS2_k127_4354216_6	1348663.KCH_74190	1.773e-38	153.0	COG0730@1|root,COG0730@2|Bacteria,2HGFV@201174|Actinobacteria,2M5X1@2063|Kitasatospora	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
TLS2_k127_4354216_8	1236902.ANAS01000005_gene4948	3.247e-22	103.0	COG0607@1|root,COG0607@2|Bacteria,2IQIP@201174|Actinobacteria,4EK4J@85012|Streptosporangiales	201174|Actinobacteria	P	Rhodanese Homology Domain	glpE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_4354216_4	1463903.JOIZ01000037_gene5471	2.127e-156	507.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria	201174|Actinobacteria	P	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
TLS2_k127_4354216_7	35754.JNYJ01000014_gene4708	1.687e-23	113.0	COG1937@1|root,COG1937@2|Bacteria,2IQ7U@201174|Actinobacteria,4DEZQ@85008|Micromonosporales	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	csoR	-	-	-	-	-	-	-	-	-	-	-	Trns_repr_metal
TLS2_k127_4354216_5	1298863.AUEP01000003_gene2850	6.29e-100	330.0	COG1321@1|root,COG1321@2|Bacteria,2GKMC@201174|Actinobacteria,4DP20@85009|Propionibacteriales	201174|Actinobacteria	K	Helix-turn-helix diphteria tox regulatory element	ideR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
TLS2_k127_4446421_2	469371.Tbis_1985	4.117e-32	142.0	COG0363@1|root,COG0363@2|Bacteria,2GMQ2@201174|Actinobacteria,4DXRG@85010|Pseudonocardiales	201174|Actinobacteria	G	6-phosphogluconolactonase	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:1901135,GO:1901360,GO:1901564	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
TLS2_k127_4446421_0	266940.Krad_2925	7.867e-107	361.0	COG3429@1|root,COG3429@2|Bacteria,2GJ1H@201174|Actinobacteria	201174|Actinobacteria	G	dehydrogenase subunit	opcA	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
TLS2_k127_4446421_1	266940.Krad_2924	2.541e-77	259.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TLS2_k127_4452045_1	1048339.KB913029_gene4518	1.127e-129	419.0	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria,4ERQ6@85013|Frankiales	201174|Actinobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_4452045_0	1380370.JIBA01000013_gene1577	2.698e-190	633.0	COG1511@1|root,COG1511@2|Bacteria,2I9VF@201174|Actinobacteria	201174|Actinobacteria	S	domain protein	-	-	-	ko:K01421	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_4452045_2	1380370.JIBA01000013_gene1578	5.871e-43	164.0	2F668@1|root,33YQB@2|Bacteria,2GVVI@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4465130_0	1385519.N801_05250	2.11e-213	695.0	COG1672@1|root,COG2197@1|root,COG1672@2|Bacteria,COG2197@2|Bacteria,2I3SK@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_4481402_7	561175.KB894093_gene2718	4.558e-25	110.0	COG2230@1|root,COG2230@2|Bacteria,2GJ94@201174|Actinobacteria	201174|Actinobacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	cfa	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS2_k127_4481402_4	110319.CF8_3158	1.654e-60	221.0	COG2716@1|root,COG2716@2|Bacteria,2IS2K@201174|Actinobacteria	201174|Actinobacteria	E	ACT domain	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
TLS2_k127_4481402_2	110319.CF8_3157	4.056e-75	265.0	COG0242@1|root,COG0242@2|Bacteria,2HMJS@201174|Actinobacteria,4DNQP@85009|Propionibacteriales	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TLS2_k127_4481402_0	1386089.N865_19910	8.448e-134	441.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4FFFI@85021|Intrasporangiaceae	201174|Actinobacteria	P	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS2_k127_4481402_5	1476876.JOJO01000030_gene3184	3.369e-43	163.0	COG0454@1|root,COG0456@2|Bacteria,2INHM@201174|Actinobacteria	201174|Actinobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_4481402_1	1132441.KI519455_gene3658	9.899e-79	275.0	COG3662@1|root,COG3662@2|Bacteria,2GJD2@201174|Actinobacteria,1W93C@1268|Micrococcaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
TLS2_k127_4481402_3	1304865.JAGF01000001_gene324	7.398e-75	260.0	COG4760@1|root,COG4760@2|Bacteria,2GNCK@201174|Actinobacteria,4F210@85016|Cellulomonadaceae	201174|Actinobacteria	S	Bax inhibitor 1 like	-	-	-	-	-	-	-	-	-	-	-	-	BaxI_1
TLS2_k127_4481402_6	1120950.KB892752_gene6190	7.171e-32	129.0	2E5A7@1|root,3302F@2|Bacteria,2IQ7Z@201174|Actinobacteria,4DVUC@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF4287)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
TLS2_k127_4504707_4	1123320.KB889719_gene7350	1.619e-62	218.0	COG1146@1|root,COG1146@2|Bacteria,2IKVN@201174|Actinobacteria	201174|Actinobacteria	C	Ferredoxin	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	Fer4
TLS2_k127_4504707_5	1048339.KB913029_gene33	1.338e-61	226.0	COG0454@1|root,COG0456@2|Bacteria,2H5WU@201174|Actinobacteria,4ET2R@85013|Frankiales	201174|Actinobacteria	K	FR47-like protein	-	-	2.3.1.1	ko:K22476	ko00220,ko01210,ko01230,map00220,map01210,map01230	-	R00259	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,FR47
TLS2_k127_4504707_3	1123320.KB889719_gene7348	4.62e-76	264.0	COG2912@1|root,COG2912@2|Bacteria,2GMER@201174|Actinobacteria	201174|Actinobacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
TLS2_k127_4504707_0	1120950.KB892823_gene520	1.253e-137	458.0	COG2720@1|root,COG2720@2|Bacteria,2GISH@201174|Actinobacteria,4DN8K@85009|Propionibacteriales	201174|Actinobacteria	V	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
TLS2_k127_4504707_6	1961.JOAK01000005_gene399	0.0002874	51.0	2E9EF@1|root,333MW@2|Bacteria,2IQ5H@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4504707_2	1380356.JNIK01000013_gene4282	2.238e-99	339.0	COG2120@1|root,COG2120@2|Bacteria,2GKUM@201174|Actinobacteria,4ES8C@85013|Frankiales	201174|Actinobacteria	S	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway	mshB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016020,GO:0016137,GO:0016138,GO:0016787,GO:0016810,GO:0016811,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	3.5.1.103	ko:K15525	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_4504707_1	1380347.JNII01000006_gene1658	3.855e-137	440.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4ERXF@85013|Frankiales	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS2_k127_4516363_3	485913.Krac_7114	5.38e-32	131.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_4516363_4	936548.HMPREF1136_1928	1.048e-11	78.0	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,4D3B2@85005|Actinomycetales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_4516363_2	1386089.N865_16650	6.431e-43	166.0	2ANPZ@1|root,31DPH@2|Bacteria,2INCA@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4516363_1	1179773.BN6_06190	2.619e-85	293.0	COG2267@1|root,COG2267@2|Bacteria,2GJUE@201174|Actinobacteria,4E36H@85010|Pseudonocardiales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_4516363_0	935866.JAER01000004_gene3719	1.885e-162	521.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4DN7A@85009|Propionibacteriales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4524643_11	1246448.ANAZ01000009_gene2766	2.537e-18	99.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,4EH1B@85012|Streptosporangiales	201174|Actinobacteria	L	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,Viral_helicase1
TLS2_k127_4524643_1	1120950.KB892800_gene1626	3.223e-216	679.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,4DP18@85009|Propionibacteriales	201174|Actinobacteria	L	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD_C_2,Viral_helicase1
TLS2_k127_4524643_3	479435.Kfla_1666	1.707e-164	521.0	COG0451@1|root,COG0451@2|Bacteria,2I2SW@201174|Actinobacteria,4DU6J@85009|Propionibacteriales	201174|Actinobacteria	GM	RmlD substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_4524643_4	479435.Kfla_1667	4.397e-163	518.0	COG1595@1|root,COG1595@2|Bacteria,2GKBH@201174|Actinobacteria,4DPZI@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
TLS2_k127_4524643_10	1122138.AQUZ01000001_gene1854	3.037e-55	201.0	COG0262@1|root,COG0262@2|Bacteria,2GMZV@201174|Actinobacteria,4DQDQ@85009|Propionibacteriales	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_4524643_14	215803.DB30_7373	0.0004832	49.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42NWJ@68525|delta/epsilon subdivisions,2WKW7@28221|Deltaproteobacteria,2YW7I@29|Myxococcales	28221|Deltaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_4524643_7	1150864.MILUP08_42014	5.442e-72	245.0	COG5646@1|root,COG5646@2|Bacteria,2IINN@201174|Actinobacteria,4DE4R@85008|Micromonosporales	201174|Actinobacteria	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS2_k127_4524643_9	1283283.ATXA01000003_gene1396	2.994e-67	242.0	COG0500@1|root,COG2226@2|Bacteria,2I2JW@201174|Actinobacteria,4EVQN@85013|Frankiales	201174|Actinobacteria	Q	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_4524643_8	1304865.JAGF01000001_gene470	5.72e-72	251.0	2DK0G@1|root,30823@2|Bacteria,2IJ7K@201174|Actinobacteria	201174|Actinobacteria	S	Rifampin ADP-ribosyl transferase	arr	-	-	ko:K19062	-	-	-	-	ko00000,ko01504	-	-	-	Arr-ms
TLS2_k127_4524643_6	1121017.AUFG01000016_gene2538	4.101e-130	422.0	COG0451@1|root,COG0451@2|Bacteria,2GP01@201174|Actinobacteria,4FEU9@85021|Intrasporangiaceae	201174|Actinobacteria	GM	epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_4524643_0	313589.JNB_13293	2.737e-232	740.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4FFVB@85021|Intrasporangiaceae	201174|Actinobacteria	G	alpha-glucosidase	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
TLS2_k127_4524643_2	1120950.KB892744_gene2775	1.042e-198	628.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria,4DP01@85009|Propionibacteriales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_4524643_5	358823.DF19_24330	1.198e-136	447.0	COG1609@1|root,COG1609@2|Bacteria,2GJBJ@201174|Actinobacteria	201174|Actinobacteria	K	lacI family	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
TLS2_k127_4524643_12	863365.XHC_0141	2.394e-14	81.0	COG2020@1|root,COG2020@2|Bacteria,1N936@1224|Proteobacteria,1SCXB@1236|Gammaproteobacteria,1X823@135614|Xanthomonadales	135614|Xanthomonadales	O	Methyltransferase	-	-	2.1.1.100	ko:K00587	ko00900,ko01130,map00900,map01130	-	R04496	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	PEMT
TLS2_k127_4524643_13	1463917.JODC01000004_gene6266	2.003e-13	73.0	COG3385@1|root,COG3385@2|Bacteria,2H68X@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
TLS2_k127_4555843_0	1122138.AQUZ01000068_gene2438	2.985e-220	706.0	COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,4DTEN@85009|Propionibacteriales	201174|Actinobacteria	L	SNF2 Helicase protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
TLS2_k127_4555843_5	526225.Gobs_4726	0.0001164	46.0	COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
TLS2_k127_4555843_2	35754.JNYJ01000063_gene1448	5.681e-77	268.0	COG1940@1|root,COG1940@2|Bacteria,2II6S@201174|Actinobacteria	201174|Actinobacteria	GK	ROK family	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	ROK
TLS2_k127_4555843_1	929712.KI912613_gene2770	3.687e-131	429.0	COG4292@1|root,COG4292@2|Bacteria,2GJPB@201174|Actinobacteria,4CSJZ@84995|Rubrobacteria	84995|Rubrobacteria	S	Bacterial low temperature requirement A protein (LtrA)	-	-	-	-	-	-	-	-	-	-	-	-	LtrA
TLS2_k127_4555843_3	1089544.KB912942_gene4818	9.376e-64	227.0	COG0748@1|root,COG0748@2|Bacteria,2IP6Y@201174|Actinobacteria	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS2_k127_4555843_4	1172188.KB911821_gene1279	4.558e-25	110.0	2EMYX@1|root,33FM2@2|Bacteria,2GZ6D@201174|Actinobacteria,4FJGG@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4557494_7	1123320.KB889698_gene9323	1.281e-76	268.0	COG2133@1|root,COG3055@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3055@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Calx-beta,GSDH,Laminin_G_3,Malectin,PKD
TLS2_k127_4557494_2	391037.Sare_3193	2.569e-132	428.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4DBTB@85008|Micromonosporales	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_4557494_3	543632.JOJL01000066_gene1362	1.196e-125	412.0	COG3622@1|root,COG3622@2|Bacteria,2GKPC@201174|Actinobacteria,4DKEP@85008|Micromonosporales	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_4557494_1	543632.JOJL01000066_gene1363	6.395e-136	440.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria,4DBT5@85008|Micromonosporales	201174|Actinobacteria	S	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose)	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4557494_5	526225.Gobs_2760	1.723e-115	382.0	COG1609@1|root,COG1609@2|Bacteria,2GK1X@201174|Actinobacteria,4ET1H@85013|Frankiales	201174|Actinobacteria	K	periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_4557494_10	1120950.KB892801_gene1701	2.763e-27	125.0	2BZ6B@1|root,30N1Q@2|Bacteria,2I097@201174|Actinobacteria,4DWBN@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4557494_0	1043493.BBLU01000006_gene2209	3.367e-149	498.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria	201174|Actinobacteria	NU	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_4557494_4	2045.KR76_12815	3.85e-124	409.0	COG1253@1|root,COG1253@2|Bacteria,2GJ8X@201174|Actinobacteria,4DNDS@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
TLS2_k127_4557494_13	298653.Franean1_5368	0.0004547	51.0	2EM5W@1|root,335MU@2|Bacteria,2GVYV@201174|Actinobacteria	201174|Actinobacteria	S	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
TLS2_k127_4557494_6	1068980.ARVW01000001_gene5346	1.472e-103	343.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria,4DZUQ@85010|Pseudonocardiales	201174|Actinobacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
TLS2_k127_4557494_12	1210908.HSB1_09030	0.0003849	51.0	COG1413@1|root,arCOG02966@2157|Archaea,2XSWS@28890|Euryarchaeota,23SIB@183963|Halobacteria	183963|Halobacteria	C	COG1413 FOG HEAT repeat	cpcE2	-	-	ko:K22221	-	-	-	-	ko00000	-	-	-	HEAT_2,HEAT_PBS
TLS2_k127_4557494_11	1166018.FAES_2320	8.194e-26	124.0	2DUW5@1|root,33SNU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4557494_9	479431.Namu_2504	3.251e-39	149.0	2E7YB@1|root,332CR@2|Bacteria,2IRTP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
TLS2_k127_4557494_8	1171373.PACID_17280	2.387e-67	237.0	COG0262@1|root,COG0262@2|Bacteria,2IHZ7@201174|Actinobacteria,4DQPQ@85009|Propionibacteriales	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_4580653_1	1121920.AUAU01000002_gene2055	6.785e-16	83.0	COG0745@1|root,COG0745@2|Bacteria,3Y4GX@57723|Acidobacteria	57723|Acidobacteria	T	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_4580653_0	37919.EP51_00195	3.005e-154	501.0	COG0654@1|root,COG0654@2|Bacteria,2GKUZ@201174|Actinobacteria,4FYKD@85025|Nocardiaceae	201174|Actinobacteria	CH	FAD binding domain	sppF	-	1.14.13.200	ko:K14672,ko:K15972	ko01057,ko01130,map01057,map01130	M00783	R06704,R10954	RC02681	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	FAD_binding_3
TLS2_k127_4604681_5	1454010.JEOE01000008_gene1887	2.592e-26	108.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4F117@85016|Cellulomonadaceae	201174|Actinobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS2_k127_4604681_4	396014.BF93_16200	2.723e-98	354.0	COG0580@1|root,COG0580@2|Bacteria,2GKK3@201174|Actinobacteria,4FCCW@85020|Dermabacteraceae	201174|Actinobacteria	G	Belongs to the MIP aquaporin (TC 1.A.8) family	glpF	-	-	ko:K02440	-	-	-	-	ko00000,ko02000	1.A.8.1,1.A.8.2	-	-	MIP
TLS2_k127_4604681_0	477641.MODMU_5534	4.339e-278	866.0	COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,4ES07@85013|Frankiales	201174|Actinobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TLS2_k127_4604681_2	479432.Sros_4519	4.498e-170	558.0	COG1680@1|root,COG1680@2|Bacteria,2GN1H@201174|Actinobacteria,4EHZU@85012|Streptosporangiales	201174|Actinobacteria	V	Beta-lactamase	blaA2	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
TLS2_k127_4604681_1	1033730.CAHG01000008_gene3124	4.971e-243	760.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4DN2S@85009|Propionibacteriales	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
TLS2_k127_4604681_3	1123322.KB904713_gene5263	1.223e-159	514.0	COG0150@1|root,COG0150@2|Bacteria,2GJNY@201174|Actinobacteria	201174|Actinobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_462337_16	1120950.KB892767_gene5180	3.271e-26	113.0	2D1T0@1|root,32TBA@2|Bacteria,2I8E5@201174|Actinobacteria,4DRW3@85009|Propionibacteriales	201174|Actinobacteria	S	Copper transport outer membrane protein, MctB	mctB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0008150,GO:0009279,GO:0015267,GO:0015288,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0044425,GO:0044462,GO:0044464,GO:0046930,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796	-	-	-	-	-	-	-	-	-	-	MctB
TLS2_k127_462337_12	1048339.KB913029_gene4071	5.271e-75	263.0	COG0472@1|root,COG0472@2|Bacteria,2HS8K@201174|Actinobacteria,4EVBR@85013|Frankiales	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_462337_4	1123320.KB889701_gene9163	1.606e-136	455.0	COG0728@1|root,COG0728@2|Bacteria,2GKWW@201174|Actinobacteria	201174|Actinobacteria	M	virulence factor MVIN family protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TLS2_k127_462337_7	1048339.KB913029_gene4073	1.092e-95	334.0	COG0438@1|root,COG0438@2|Bacteria,2GN28@201174|Actinobacteria,4EXFY@85013|Frankiales	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_462337_0	1048339.KB913029_gene4074	7.021e-300	927.0	COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria,4ERGE@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1699	CTP_synth_N,GATase
TLS2_k127_462337_10	1120950.KB892767_gene5173	4.758e-80	284.0	COG0494@1|root,COG0494@2|Bacteria,2GNW6@201174|Actinobacteria,4DR6U@85009|Propionibacteriales	201174|Actinobacteria	L	NUDIX domain	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TLS2_k127_462337_15	465541.ATCJ01000001_gene454	1.546e-35	148.0	2DF72@1|root,32U4U@2|Bacteria,2GIV4@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_462337_2	479435.Kfla_5119	1.583e-186	590.0	COG0686@1|root,COG0686@2|Bacteria,2GJ6G@201174|Actinobacteria,4DNSB@85009|Propionibacteriales	201174|Actinobacteria	E	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TLS2_k127_462337_3	1120950.KB892767_gene5149	7.126e-137	442.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4DNSC@85009|Propionibacteriales	201174|Actinobacteria	L	tyrosine recombinase	xerD	GO:0008150,GO:0040007	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_462337_5	351607.Acel_1240	1.056e-132	431.0	COG1192@1|root,COG1192@2|Bacteria,2GJX3@201174|Actinobacteria,4ERYA@85013|Frankiales	201174|Actinobacteria	D	PFAM Cobyrinic acid a,c-diamide synthase	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS2_k127_462337_17	1283287.KB822585_gene2645	2.164e-17	97.0	2E3JK@1|root,32YHZ@2|Bacteria,2GS0Y@201174|Actinobacteria,4DRQ0@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_462337_6	1048339.KB913029_gene4083	3.15e-102	358.0	COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria,4ERDV@85013|Frankiales	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
TLS2_k127_462337_11	680198.SCAB_71871	2.882e-77	263.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
TLS2_k127_462337_8	1386089.N865_15420	1.348e-94	323.0	COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,4FEXM@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_462337_14	1121946.AUAX01000004_gene936	1.121e-48	178.0	COG4401@1|root,COG4401@2|Bacteria,2IHWT@201174|Actinobacteria	201174|Actinobacteria	E	Chorismate mutase	-	-	5.4.99.5	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_1
TLS2_k127_462337_9	2002.JOEQ01000024_gene122	1.395e-92	321.0	COG0287@1|root,COG0287@2|Bacteria,2GKB4@201174|Actinobacteria,4EG77@85012|Streptosporangiales	201174|Actinobacteria	E	Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
TLS2_k127_462337_13	1454010.JEOE01000001_gene728	7.968e-74	259.0	COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,4F0T2@85016|Cellulomonadaceae	201174|Actinobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyltransferase,Cytidylate_kin
TLS2_k127_462337_1	1120950.KB892761_gene5829	3.375e-216	681.0	COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria,4DNFK@85009|Propionibacteriales	201174|Actinobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	Cytidylate_kin,KH_dom-like,MMR_HSR1
TLS2_k127_462337_18	710111.FraQA3DRAFT_4238	9.38e-07	57.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4EV73@85013|Frankiales	201174|Actinobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_4645017_2	675635.Psed_0407	2.978e-132	454.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,4DXD0@85010|Pseudonocardiales	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_4645017_0	471853.Bcav_3373	7.744e-269	835.0	COG4147@1|root,COG4147@2|Bacteria,2GJ56@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	actP	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
TLS2_k127_4645017_5	471853.Bcav_3374	1.015e-44	165.0	COG3162@1|root,COG3162@2|Bacteria,2IQ5D@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
TLS2_k127_4645017_1	471852.Tcur_3170	1.321e-243	767.0	COG4147@1|root,COG4147@2|Bacteria,2GM3H@201174|Actinobacteria,4EHAX@85012|Streptosporangiales	201174|Actinobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
TLS2_k127_4645017_6	471853.Bcav_3376	2.645e-33	140.0	2E3NY@1|root,32YM2@2|Bacteria,2II83@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
TLS2_k127_4645017_3	1122138.AQUZ01000021_gene8603	1.693e-97	333.0	COG3279@1|root,COG3279@2|Bacteria,2GKK5@201174|Actinobacteria,4DQ9E@85009|Propionibacteriales	201174|Actinobacteria	T	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
TLS2_k127_4645017_4	28444.JODQ01000007_gene5367	1.205e-78	265.0	COG3275@1|root,COG3275@2|Bacteria,2GJD4@201174|Actinobacteria,4EGVS@85012|Streptosporangiales	201174|Actinobacteria	T	Histidine kinase	yehU	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
TLS2_k127_4675276_0	479435.Kfla_5701	0.0	1200.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4DNWF@85009|Propionibacteriales	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS2_k127_468678_0	526225.Gobs_3888	0.0	1277.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria	201174|Actinobacteria	P	Heavy metal translocating P-type atpase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS2_k127_468678_10	1206732.BAGD01000097_gene4366	6.359e-07	56.0	COG5513@1|root,COG5513@2|Bacteria,2GXM1@201174|Actinobacteria,4G4J0@85025|Nocardiaceae	201174|Actinobacteria	S	Chagasin family peptidase inhibitor I42	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	Inhibitor_I42
TLS2_k127_468678_9	929703.KE386491_gene1670	4.669e-15	87.0	COG4870@1|root,COG4870@2|Bacteria,4NQK4@976|Bacteroidetes,47XFW@768503|Cytophagia	976|Bacteroidetes	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
TLS2_k127_468678_4	526225.Gobs_3687	2.259e-69	241.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Rrf2
TLS2_k127_468678_6	66373.JOFQ01000008_gene103	1.921e-36	154.0	2DM0Y@1|root,318KY@2|Bacteria,2IMIX@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF1992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1992
TLS2_k127_468678_5	644283.Micau_4166	5.195e-60	224.0	2AVV0@1|root,31MNQ@2|Bacteria,2GJKP@201174|Actinobacteria,4DD7U@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3159
TLS2_k127_468678_1	1464048.JNZS01000010_gene5079	1.38e-276	857.0	COG0069@1|root,COG0069@2|Bacteria,2GME2@201174|Actinobacteria,4DC09@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the glutamate synthase family	gltB_1	-	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	Glu_synthase
TLS2_k127_468678_2	479431.Namu_0392	9.242e-72	260.0	COG4325@1|root,COG4325@2|Bacteria,2GWFP@201174|Actinobacteria,4EUTU@85013|Frankiales	201174|Actinobacteria	S	Predicted membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
TLS2_k127_468678_7	1907.SGLAU_03150	1.294e-34	155.0	COG0501@1|root,COG0501@2|Bacteria,2GZ0N@201174|Actinobacteria	201174|Actinobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS2_k127_468678_8	1172188.KB911820_gene2155	2.199e-18	91.0	2B2RZ@1|root,31VC7@2|Bacteria,2GVDD@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_468678_3	266940.Krad_2049	1.247e-71	251.0	COG4715@1|root,COG4715@2|Bacteria,2GKC8@201174|Actinobacteria	201174|Actinobacteria	K	PFAM zinc finger SWIM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
TLS2_k127_4688788_1	1120949.KB903295_gene2354	7.863e-255	800.0	COG1012@1|root,COG1012@2|Bacteria,2GJI2@201174|Actinobacteria,4D8Q2@85008|Micromonosporales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_4688788_0	33876.JNXY01000016_gene6911	1.325e-290	915.0	COG3962@1|root,COG3962@2|Bacteria,2GMCJ@201174|Actinobacteria,4D98S@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the TPP enzyme family	iolD	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS2_k127_4688788_4	1169161.KB897713_gene6557	3.236e-128	431.0	COG3718@1|root,COG3718@2|Bacteria,2GM8S@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Myo-inositol catabolism IolB domain protein	iolB	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
TLS2_k127_4688788_8	1120949.KB903295_gene2357	9.23e-117	397.0	COG1830@1|root,COG1830@2|Bacteria,2GKTN@201174|Actinobacteria,4DBMP@85008|Micromonosporales	201174|Actinobacteria	G	deoxyribose-phosphate aldolase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4688788_3	1151061.CAJY01000036_gene1598	2.302e-129	445.0	COG0524@1|root,COG0524@2|Bacteria,2GM3N@201174|Actinobacteria	201174|Actinobacteria	G	PFAM PfkB domain protein	iolC	-	2.7.1.92	ko:K03338	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R05661	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS2_k127_4688788_5	479435.Kfla_1685	2.387e-127	420.0	COG1082@1|root,COG1082@2|Bacteria,2GJKJ@201174|Actinobacteria,4DPUG@85009|Propionibacteriales	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_4688788_7	1236902.ANAS01000005_gene4521	3.076e-121	400.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria,4EFK8@85012|Streptosporangiales	201174|Actinobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4688788_10	1120950.KB892707_gene4829	2.87e-87	303.0	COG2188@1|root,COG2188@2|Bacteria,2GJZ1@201174|Actinobacteria,4DQMB@85009|Propionibacteriales	201174|Actinobacteria	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS2_k127_4688788_2	479435.Kfla_2821	2.688e-152	489.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,4DNXD@85009|Propionibacteriales	201174|Actinobacteria	GK	ROK family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_4688788_9	309801.trd_1581	1.615e-109	376.0	COG1982@1|root,COG1982@2|Bacteria,2GA2R@200795|Chloroflexi,27YUZ@189775|Thermomicrobia	189775|Thermomicrobia	E	Orn/Lys/Arg decarboxylase, C-terminal domain	-	-	4.1.1.18	ko:K01582	ko00310,ko00960,ko01100,ko01110,map00310,map00960,map01100,map01110	-	R00462	RC00299	ko00000,ko00001,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
TLS2_k127_4688788_6	2074.JNYD01000026_gene644	1.408e-126	419.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4E08C@85010|Pseudonocardiales	201174|Actinobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS2_k127_4688788_11	1385519.N801_05260	7.979e-81	277.0	COG3832@1|root,COG3832@2|Bacteria,2GY9A@201174|Actinobacteria	201174|Actinobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4688788_12	1146883.BLASA_0959	1.659e-20	93.0	COG4122@1|root,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24,TylF
TLS2_k127_4689425_2	1172188.KB911822_gene1168	6.975e-29	117.0	COG4974@1|root,COG4974@2|Bacteria,2ID5W@201174|Actinobacteria,4FFEX@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
TLS2_k127_4689425_1	1068978.AMETH_4802	5.293e-71	248.0	COG2318@1|root,COG2318@2|Bacteria,2HUJD@201174|Actinobacteria,4EANK@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
TLS2_k127_4689425_3	134676.ACPL_2014	7.507e-16	81.0	COG2513@1|root,COG2513@2|Bacteria,2GMQ4@201174|Actinobacteria,4DEP9@85008|Micromonosporales	201174|Actinobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
TLS2_k127_4689425_0	680198.SCAB_34181	2.805e-120	398.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	ko:K04753	-	-	-	-	ko00000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
TLS2_k127_4689425_4	1288079.AUKN01000003_gene3478	2.257e-11	67.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	ko:K04753	-	-	-	-	ko00000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
TLS2_k127_4713539_11	477641.MODMU_3843	1.446e-26	113.0	COG3795@1|root,COG3795@2|Bacteria,2IIV2@201174|Actinobacteria	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_4713539_3	269799.Gmet_1194	1.667e-115	413.0	2DB7D@1|root,2Z7KR@2|Bacteria,1Q0FB@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4713539_1	160799.PBOR_19175	8.475e-146	511.0	28JBD@1|root,2Z964@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4713539_13	1151118.KB895787_gene1273	1.575e-22	101.0	COG3795@1|root,COG3795@2|Bacteria,2IIV2@201174|Actinobacteria	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_4713539_5	1122138.AQUZ01000025_gene2758	2.121e-96	332.0	COG3409@1|root,COG3409@2|Bacteria,2I03A@201174|Actinobacteria,4DVCQ@85009|Propionibacteriales	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4713539_12	1123320.KB889684_gene2357	7.04e-24	111.0	COG3409@1|root,COG3409@2|Bacteria,2HB3I@201174|Actinobacteria	201174|Actinobacteria	M	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,PG_binding_1
TLS2_k127_4713539_10	882083.SacmaDRAFT_1617	4.27e-29	126.0	COG3409@1|root,COG3409@2|Bacteria,2GR1Q@201174|Actinobacteria,4DYAX@85010|Pseudonocardiales	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,LysM,PG_binding_1
TLS2_k127_4713539_0	196162.Noca_3107	8.332e-191	603.0	COG1915@1|root,COG1915@2|Bacteria,2GMEZ@201174|Actinobacteria,4DN71@85009|Propionibacteriales	201174|Actinobacteria	S	LOR/SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
TLS2_k127_4713539_14	1134445.AJJM01000038_gene560	1.112e-19	103.0	2EN8E@1|root,33FW7@2|Bacteria,2GMI1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4713539_8	465541.ATCJ01000005_gene2893	6.11e-82	286.0	COG1647@1|root,COG1647@2|Bacteria,2GM1Y@201174|Actinobacteria	201174|Actinobacteria	S	Esterase	yvaK	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
TLS2_k127_4713539_4	1120950.KB892707_gene4850	3.091e-105	348.0	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria,4DP1S@85009|Propionibacteriales	201174|Actinobacteria	I	Acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_4713539_6	1120950.KB892707_gene4851	7.781e-95	324.0	COG4585@1|root,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4DNBA@85009|Propionibacteriales	201174|Actinobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_4713539_7	33898.JRHJ01000050_gene8163	8.723e-87	294.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_4713539_9	1385520.N802_19025	4.919e-39	155.0	2ECMH@1|root,336JI@2|Bacteria,2IQU7@201174|Actinobacteria,4FJ0B@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4713539_2	1385519.N801_13440	3.273e-124	413.0	28PI0@1|root,2ZC87@2|Bacteria,2IDWK@201174|Actinobacteria,4FIK5@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VKG_Carbox
TLS2_k127_4713539_16	656024.FsymDg_2192	4.294e-10	66.0	COG0607@1|root,COG0607@2|Bacteria,2IKTC@201174|Actinobacteria,4ET2W@85013|Frankiales	201174|Actinobacteria	P	SMART Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_4724374_1	196162.Noca_3885	1.251e-86	288.0	COG0201@1|root,COG0201@2|Bacteria,2GJ26@201174|Actinobacteria,4DN3Y@85009|Propionibacteriales	201174|Actinobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
TLS2_k127_4724374_2	1283287.KB822575_gene134	1.215e-73	260.0	COG0563@1|root,COG0563@2|Bacteria,2GJ7T@201174|Actinobacteria,4DP2T@85009|Propionibacteriales	201174|Actinobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
TLS2_k127_4724374_0	298655.KI912266_gene301	9.598e-101	338.0	COG0024@1|root,COG0024@2|Bacteria,2GKKB@201174|Actinobacteria,4ERZ1@85013|Frankiales	201174|Actinobacteria	J	TIGRFAM methionine aminopeptidase, type I	mapA	GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016020,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901605	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS2_k127_4724374_5	909613.UO65_1252	1.239e-37	153.0	COG0361@1|root,COG0361@2|Bacteria,2IQ4B@201174|Actinobacteria,4E5BJ@85010|Pseudonocardiales	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071944	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
TLS2_k127_4724374_6	471853.Bcav_3116	3.374e-16	79.0	COG0257@1|root,COG0257@2|Bacteria,2GWMH@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
TLS2_k127_4724374_3	471852.Tcur_4293	1.783e-61	220.0	COG0099@1|root,COG0099@2|Bacteria,2IHPN@201174|Actinobacteria,4EJ74@85012|Streptosporangiales	201174|Actinobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
TLS2_k127_4724374_4	67352.JODS01000006_gene6484	2.365e-46	168.0	COG0100@1|root,COG0100@2|Bacteria,2IFFC@201174|Actinobacteria	201174|Actinobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
TLS2_k127_473461_0	1385518.N798_10680	1.488e-227	719.0	COG2234@1|root,COG2234@2|Bacteria,2GIT0@201174|Actinobacteria,4FJVK@85021|Intrasporangiaceae	201174|Actinobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
TLS2_k127_473461_1	1122182.KB903837_gene3736	7.768e-155	511.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria,4D9KJ@85008|Micromonosporales	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_473461_2	543632.JOJL01000007_gene5535	2.013e-115	374.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4DAHS@85008|Micromonosporales	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	bkdB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_4753104_0	1283299.AUKG01000001_gene2437	2.919e-117	415.0	COG3899@1|root,COG3899@2|Bacteria,2HFRA@201174|Actinobacteria,4CR76@84995|Rubrobacteria	84995|Rubrobacteria	T	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
TLS2_k127_4753104_3	2074.JNYD01000017_gene4322	1.583e-54	198.0	COG5403@1|root,COG5403@2|Bacteria,2IKKK@201174|Actinobacteria	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
TLS2_k127_4753104_2	479432.Sros_1504	4.864e-61	226.0	COG1280@1|root,COG1280@2|Bacteria,2GMDP@201174|Actinobacteria,4EIVP@85012|Streptosporangiales	201174|Actinobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
TLS2_k127_4753104_1	405948.SACE_5324	6.275e-70	244.0	COG4221@1|root,COG4221@2|Bacteria,2IBSS@201174|Actinobacteria,4DZGG@85010|Pseudonocardiales	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_4761585_0	1089551.KE386572_gene1381	1.38e-101	351.0	COG2133@1|root,COG2133@2|Bacteria,1R86D@1224|Proteobacteria,2U1Z1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,GSDH
TLS2_k127_4768951_4	1120950.KB892823_gene462	1.68e-73	258.0	COG2267@1|root,COG2267@2|Bacteria,2GKPK@201174|Actinobacteria,4DQN5@85009|Propionibacteriales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
TLS2_k127_4768951_0	1122138.AQUZ01000003_gene615	5.38e-91	328.0	COG1387@1|root,COG1387@2|Bacteria,2I6QG@201174|Actinobacteria,4DX3G@85009|Propionibacteriales	201174|Actinobacteria	E	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
TLS2_k127_4768951_5	351607.Acel_1797	2.825e-67	239.0	29V8K@1|root,30GNI@2|Bacteria,2GM77@201174|Actinobacteria,4ESYF@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4768951_6	1120950.KB892823_gene467	1.261e-40	156.0	COG1051@1|root,COG1051@2|Bacteria,2IQEU@201174|Actinobacteria,4DSD6@85009|Propionibacteriales	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_4768951_3	110319.CF8_1221	3.144e-76	259.0	COG0406@1|root,COG0406@2|Bacteria,2GNRS@201174|Actinobacteria,4DQ6Z@85009|Propionibacteriales	201174|Actinobacteria	G	Phosphoglycerate mutase family	gpm2	GO:0003674,GO:0003824,GO:0003993,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0042802,GO:0042803,GO:0044237,GO:0046983	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TLS2_k127_4768951_1	391037.Sare_0676	2.087e-87	295.0	COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4D9AA@85008|Micromonosporales	201174|Actinobacteria	I	Maoc domain protein dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS2_k127_4768951_2	1385520.N802_07405	4.87e-86	296.0	COG4427@1|root,COG4427@2|Bacteria,2HVQW@201174|Actinobacteria,4FG8R@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2332
TLS2_k127_4768951_7	1123322.KB904634_gene2184	1.173e-10	63.0	2CAW2@1|root,32RS7@2|Bacteria,2IB15@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4789827_12	1121877.JQKF01000007_gene1022	1.763e-111	364.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria	201174|Actinobacteria	O	ATPase associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
TLS2_k127_4789827_13	469383.Cwoe_3031	2.001e-104	351.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4CRRF@84995|Rubrobacteria	84995|Rubrobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS2_k127_4789827_23	1121019.AUMN01000007_gene2442	0.0001124	53.0	2E56G@1|root,32ZZ6@2|Bacteria,2GR3Y@201174|Actinobacteria,1W9WH@1268|Micrococcaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4789827_7	1172179.AUKV01000058_gene1382	4.557e-121	395.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	regX3	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_4789827_6	1120950.KB892790_gene2080	3.215e-126	418.0	COG5002@1|root,COG5002@2|Bacteria,2GJY7@201174|Actinobacteria,4DP15@85009|Propionibacteriales	201174|Actinobacteria	T	Histidine kinase	senX3	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K07768	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
TLS2_k127_4789827_16	1120950.KB892790_gene2081	3.073e-61	224.0	COG0704@1|root,COG0704@2|Bacteria,2GKAD@201174|Actinobacteria,4DQEB@85009|Propionibacteriales	201174|Actinobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TLS2_k127_4789827_4	1172180.KB911796_gene8118	1.08e-130	421.0	COG0588@1|root,COG0588@2|Bacteria,2GK8F@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
TLS2_k127_4789827_17	1123322.KB904692_gene4463	3.31e-60	212.0	2AZ39@1|root,31R9K@2|Bacteria,2GMCY@201174|Actinobacteria	201174|Actinobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
TLS2_k127_4789827_0	1120950.KB892790_gene2087	1.906e-180	580.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4DN29@85009|Propionibacteriales	201174|Actinobacteria	M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway	mshA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_4789827_15	1172186.KB911471_gene2843	4.292e-66	237.0	COG2110@1|root,COG2110@2|Bacteria,2IFEC@201174|Actinobacteria,235P3@1762|Mycobacteriaceae	201174|Actinobacteria	S	Appr-1'-p processing enzyme	lppD	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Macro
TLS2_k127_4789827_5	767029.HMPREF9154_1763	7.189e-129	423.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria,4DP9F@85009|Propionibacteriales	201174|Actinobacteria	M	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
TLS2_k127_4789827_11	526225.Gobs_3806	3.848e-113	369.0	COG2872@1|root,COG2872@2|Bacteria,2I8P6@201174|Actinobacteria	201174|Actinobacteria	S	Threonyl alanyl tRNA synthetase SAD	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
TLS2_k127_4789827_14	478801.Ksed_03630	1.032e-81	281.0	COG1073@1|root,COG1073@2|Bacteria,2I2F1@201174|Actinobacteria,1ZVX4@145357|Dermacoccaceae	201174|Actinobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
TLS2_k127_4789827_20	1385521.N803_03770	5.594e-22	108.0	2EHMU@1|root,33BDI@2|Bacteria,2GQGA@201174|Actinobacteria,4FHT4@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2516)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2516
TLS2_k127_4789827_24	436229.JOEH01000012_gene5064	0.0003862	51.0	28UHU@1|root,2ZGNH@2|Bacteria,2I8HA@201174|Actinobacteria,2NI64@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	ko:K16645	-	-	-	-	ko00000,ko00536	-	-	-	-
TLS2_k127_4789827_19	471852.Tcur_0663	3.395e-43	160.0	COG1396@1|root,COG1396@2|Bacteria,2IKVI@201174|Actinobacteria,4EJT0@85012|Streptosporangiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
TLS2_k127_4789827_9	358823.DF19_08225	1.357e-119	397.0	COG0531@1|root,COG0531@2|Bacteria,2GJ75@201174|Actinobacteria	201174|Actinobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease,AA_permease_2
TLS2_k127_4789827_22	1312954.KI914873_gene845	1.153e-08	63.0	2ETS3@1|root,33M9I@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4789827_21	1032480.MLP_04430	2.415e-16	90.0	COG2197@1|root,COG2197@2|Bacteria,2IFE7@201174|Actinobacteria	201174|Actinobacteria	KT	regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_4789827_1	1312954.KI914871_gene2727	7.432e-166	551.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS2_k127_4789827_8	1120950.KB892790_gene2095	6.944e-120	394.0	COG4448@1|root,COG4448@2|Bacteria,2GJA7@201174|Actinobacteria,4DNR5@85009|Propionibacteriales	201174|Actinobacteria	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
TLS2_k127_4789827_3	479435.Kfla_0987	1.583e-132	427.0	COG3246@1|root,COG3246@2|Bacteria,2I9EQ@201174|Actinobacteria,4DP9Q@85009|Propionibacteriales	201174|Actinobacteria	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
TLS2_k127_4789827_2	1120950.KB892795_gene2288	6.127e-165	531.0	COG0451@1|root,COG0451@2|Bacteria,2I2EG@201174|Actinobacteria,4DP7C@85009|Propionibacteriales	201174|Actinobacteria	M	RmlD substrate binding domain	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS2_k127_4789827_18	479432.Sros_0921	5.899e-60	210.0	COG1490@1|root,COG1490@2|Bacteria,2IKVR@201174|Actinobacteria,4EJ0B@85012|Streptosporangiales	201174|Actinobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
TLS2_k127_4789827_10	471852.Tcur_0655	1.901e-115	376.0	COG0354@1|root,COG0354@2|Bacteria,2GKP0@201174|Actinobacteria,4EH49@85012|Streptosporangiales	201174|Actinobacteria	S	Glycine cleavage T-protein C-terminal barrel domain	ygfZ	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
TLS2_k127_4800626_21	1137269.AZWL01000001_gene5484	4.467e-27	113.0	COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria	201174|Actinobacteria	Q	phosphoribosyltransferase	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
TLS2_k127_4800626_5	1120950.KB892717_gene2440	7.695e-114	384.0	COG1316@1|root,COG1316@2|Bacteria,2GM55@201174|Actinobacteria,4DPV3@85009|Propionibacteriales	201174|Actinobacteria	K	cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
TLS2_k127_4800626_18	1122998.AUHZ01000009_gene1619	1.015e-40	160.0	COG3386@1|root,COG3386@2|Bacteria,2IAG8@201174|Actinobacteria,4DR1Y@85009|Propionibacteriales	201174|Actinobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4800626_2	935866.JAER01000007_gene429	4.618e-169	556.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4DNDC@85009|Propionibacteriales	201174|Actinobacteria	P	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_4800626_19	1121272.KB903272_gene90	2.034e-40	156.0	COG1309@1|root,COG1309@2|Bacteria,2IP3P@201174|Actinobacteria,4DF4E@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_4800626_12	1123319.AUBE01000004_gene433	4.29e-79	276.0	COG0421@1|root,COG0421@2|Bacteria,2GN8I@201174|Actinobacteria	201174|Actinobacteria	E	spermidine synthase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Spermine_synth
TLS2_k127_4800626_9	219305.MCAG_02727	2.343e-92	317.0	COG3178@1|root,COG3178@2|Bacteria,2GNRB@201174|Actinobacteria,4DD76@85008|Micromonosporales	201174|Actinobacteria	S	'Phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_4800626_8	1122611.KB903962_gene4526	3.11e-98	334.0	COG1793@1|root,COG1793@2|Bacteria,2IKE5@201174|Actinobacteria,4EJWG@85012|Streptosporangiales	201174|Actinobacteria	L	ATP dependent DNA ligase C terminal region	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
TLS2_k127_4800626_13	1356854.N007_14445	9.794e-79	275.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
TLS2_k127_4800626_14	1464048.JNZS01000005_gene5418	9.917e-60	214.0	COG1309@1|root,COG1309@2|Bacteria,2I31S@201174|Actinobacteria,4DE3F@85008|Micromonosporales	201174|Actinobacteria	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TLS2_k127_4800626_17	101510.RHA1_ro01052	3.121e-42	158.0	COG0346@1|root,COG0346@2|Bacteria,2IM7G@201174|Actinobacteria,4G93C@85025|Nocardiaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_4800626_0	1122611.KB904029_gene5329	0.0	1156.0	COG1882@1|root,COG1882@2|Bacteria,2GTTT@201174|Actinobacteria,4EIEU@85012|Streptosporangiales	201174|Actinobacteria	C	Glycine radical	pflB	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
TLS2_k127_4800626_10	446466.Cfla_1722	1.857e-86	293.0	COG1180@1|root,COG1180@2|Bacteria,2GN2B@201174|Actinobacteria,4F0HU@85016|Cellulomonadaceae	201174|Actinobacteria	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
TLS2_k127_4800626_16	1380390.JIAT01000009_gene664	3.95e-45	183.0	COG3832@1|root,COG3832@2|Bacteria,2II8T@201174|Actinobacteria,4CQRH@84995|Rubrobacteria	84995|Rubrobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_4800626_3	479435.Kfla_2982	5.213e-147	477.0	COG3239@1|root,COG3239@2|Bacteria,2GJKF@201174|Actinobacteria,4DP07@85009|Propionibacteriales	201174|Actinobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
TLS2_k127_4800626_6	1304865.JAGF01000001_gene2415	2.324e-106	350.0	COG2203@1|root,COG2203@2|Bacteria,2GQ2V@201174|Actinobacteria	201174|Actinobacteria	T	ANTAR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS2_k127_4800626_7	1304865.JAGF01000001_gene2416	7.192e-104	344.0	COG2203@1|root,COG2203@2|Bacteria,2IQAM@201174|Actinobacteria	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS2_k127_4800626_25	1312959.KI914706_gene2960	4.703e-17	85.0	COG5416@1|root,COG5416@2|Bacteria	2|Bacteria	FG	Lipopolysaccharide assembly protein A domain	-	-	-	-	-	-	-	-	-	-	-	-	LapA_dom
TLS2_k127_4800626_11	101510.RHA1_ro00461	6.362e-80	276.0	COG3795@1|root,COG3795@2|Bacteria,2IFD6@201174|Actinobacteria,4G0JP@85025|Nocardiaceae	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_4800626_1	1304865.JAGF01000001_gene2628	3.66e-218	682.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	sigI	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4800626_23	981369.JQMJ01000003_gene7480	1.66e-25	108.0	COG3547@1|root,COG3547@2|Bacteria,2IBF5@201174|Actinobacteria	201174|Actinobacteria	L	Transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_4800626_20	1894.JOER01000063_gene132	2.756e-37	148.0	COG3547@1|root,COG3547@2|Bacteria,2IBF5@201174|Actinobacteria	201174|Actinobacteria	L	Transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_4800626_28	1123251.ATWM01000002_gene51	1.104e-11	68.0	COG4974@1|root,COG4974@2|Bacteria,2ID5W@201174|Actinobacteria,4FFEX@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
TLS2_k127_4800626_27	1179773.BN6_21490	4.861e-14	81.0	COG4974@1|root,COG4974@2|Bacteria,2ID5W@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
TLS2_k127_4800626_15	1227499.C493_02211	1.652e-48	188.0	COG0596@1|root,arCOG07416@1|root,arCOG01648@2157|Archaea,arCOG07416@2157|Archaea,2Y385@28890|Euryarchaeota,23ZCI@183963|Halobacteria	183963|Halobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_4800626_4	487521.OCU_16500	5.263e-122	427.0	COG2114@1|root,COG2197@1|root,COG3903@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Guanylate_cyc,NB-ARC
TLS2_k127_4800626_22	35754.JNYJ01000015_gene8466	1.043e-25	111.0	COG0346@1|root,COG0346@2|Bacteria,2IFCU@201174|Actinobacteria,4DEW8@85008|Micromonosporales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4800626_24	1172188.KB911822_gene709	3.724e-20	91.0	COG0328@1|root,COG0328@2|Bacteria,2GK53@201174|Actinobacteria,4FGCT@85021|Intrasporangiaceae	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DUF4440,RNase_H
TLS2_k127_4800626_26	1172188.KB911822_gene709	1.787e-16	80.0	COG0328@1|root,COG0328@2|Bacteria,2GK53@201174|Actinobacteria,4FGCT@85021|Intrasporangiaceae	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DUF4440,RNase_H
TLS2_k127_4822005_2	1123024.AUII01000021_gene12	3.012e-136	440.0	COG1595@1|root,COG1595@2|Bacteria,2GJIZ@201174|Actinobacteria,4E28A@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4822005_4	1123024.AUII01000021_gene11	9.342e-108	372.0	COG0702@1|root,COG0702@2|Bacteria,2GM39@201174|Actinobacteria,4E3S9@85010|Pseudonocardiales	201174|Actinobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
TLS2_k127_4822005_8	1137269.AZWL01000019_gene4155	2.357e-88	295.0	COG1576@1|root,COG3832@1|root,COG1576@2|Bacteria,COG3832@2|Bacteria,2I3MI@201174|Actinobacteria	201174|Actinobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,MDMPI_N
TLS2_k127_4822005_3	649831.L083_0724	2.401e-123	411.0	COG0247@1|root,COG0247@2|Bacteria,2GIVX@201174|Actinobacteria,4D9DX@85008|Micromonosporales	201174|Actinobacteria	C	Cysteine-rich domain	lutA	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
TLS2_k127_4822005_0	1123024.AUII01000016_gene1305	1.985e-238	753.0	COG1139@1|root,COG1139@2|Bacteria,2GJDR@201174|Actinobacteria,4DZA8@85010|Pseudonocardiales	201174|Actinobacteria	C	(4Fe-4S) cluster-containing protein	lutB	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
TLS2_k127_4822005_11	68199.JNZO01000002_gene1485	6.256e-64	233.0	COG1556@1|root,COG1556@2|Bacteria,2GNUJ@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Uncharacterised ACR, YkgG family COG1556	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
TLS2_k127_4822005_13	1150398.JIBJ01000004_gene2796	1.439e-51	188.0	COG3832@1|root,COG3832@2|Bacteria,2IMM4@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_4822005_14	1123507.ATVQ01000003_gene573	2.247e-43	164.0	COG2323@1|root,COG2323@2|Bacteria,2IK7N@201174|Actinobacteria,1WBF3@1268|Micrococcaceae	201174|Actinobacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
TLS2_k127_4822005_1	1206737.BAGF01000040_gene2319	1.201e-212	685.0	COG3591@1|root,COG3591@2|Bacteria,2GM9R@201174|Actinobacteria	201174|Actinobacteria	E	Trypsin-like peptidase domain	-	-	-	ko:K01173	ko04210,map04210	-	-	-	ko00000,ko00001,ko03029	-	-	-	Endonuclease_NS,Trypsin_2
TLS2_k127_4822005_10	675635.Psed_1300	4.647e-72	260.0	COG0785@1|root,COG0785@2|Bacteria,2I8T6@201174|Actinobacteria,4E227@85010|Pseudonocardiales	201174|Actinobacteria	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
TLS2_k127_4822005_16	1136417.AZWE01000018_gene983	2.967e-34	139.0	COG0526@1|root,COG0526@2|Bacteria,2IR6C@201174|Actinobacteria,4DF6H@85008|Micromonosporales	201174|Actinobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_4822005_5	1386089.N865_08175	7.175e-98	343.0	COG0642@1|root,COG2205@2|Bacteria,2I3JI@201174|Actinobacteria,4FGKJ@85021|Intrasporangiaceae	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS2_k127_4822005_6	1386089.N865_08170	1.425e-93	314.0	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria,4FGFE@85021|Intrasporangiaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	resD	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_4822005_9	1449346.JQMO01000002_gene843	1.918e-82	288.0	COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
TLS2_k127_4822005_19	1229203.KI301992_gene583	5.467e-16	86.0	COG2172@1|root,COG2172@2|Bacteria,2IBHV@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,PAS
TLS2_k127_4822005_20	935866.JAER01000005_gene234	1.287e-09	69.0	COG2172@1|root,COG2172@2|Bacteria,2IBHV@201174|Actinobacteria,4DRB2@85009|Propionibacteriales	201174|Actinobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,PAS
TLS2_k127_4822005_7	1146883.BLASA_4828	7.255e-90	307.0	COG3861@1|root,COG3861@2|Bacteria,2II0U@201174|Actinobacteria,4EV5Z@85013|Frankiales	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382,PRC
TLS2_k127_4822005_21	1463926.JOCA01000007_gene4160	1.047e-06	59.0	2E6NT@1|root,33198@2|Bacteria,2IFTP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4822005_12	1237500.ANBA01000015_gene2247	8.26e-52	197.0	2A1WW@1|root,30Q6B@2|Bacteria,2HGNT@201174|Actinobacteria,4EKVI@85012|Streptosporangiales	201174|Actinobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
TLS2_k127_4822005_18	266940.Krad_0810	3.277e-23	109.0	COG0711@1|root,COG0711@2|Bacteria,2IQQZ@201174|Actinobacteria	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4822005_17	1068978.AMETH_0580	1.459e-30	135.0	2DMSR@1|root,32TF3@2|Bacteria,2IR08@201174|Actinobacteria,4E648@85010|Pseudonocardiales	201174|Actinobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
TLS2_k127_4822005_15	1068978.AMETH_0579	6.402e-39	153.0	2B9CE@1|root,322Q4@2|Bacteria,2IKT2@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3618)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3618
TLS2_k127_4854723_4	1120950.KB892708_gene4438	1.264e-79	281.0	COG0805@1|root,COG0805@2|Bacteria,2GJK8@201174|Actinobacteria,4DQFM@85009|Propionibacteriales	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
TLS2_k127_4854723_7	298653.Franean1_4869	8.802e-15	83.0	COG1826@1|root,COG1826@2|Bacteria,2GQQX@201174|Actinobacteria,4ETM8@85013|Frankiales	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	GO:0008150,GO:0040007	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS2_k127_4854723_2	1120950.KB892708_gene4435	4.455e-117	401.0	COG2378@1|root,COG2378@2|Bacteria,2GMAU@201174|Actinobacteria,4DP7N@85009|Propionibacteriales	201174|Actinobacteria	K	WYL domain	pafC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
TLS2_k127_4854723_3	479435.Kfla_5100	1.712e-110	368.0	COG2378@1|root,COG2378@2|Bacteria,2GM46@201174|Actinobacteria,4DNBD@85009|Propionibacteriales	201174|Actinobacteria	K	WYL domain	pafB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K13572,ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
TLS2_k127_4854723_0	479432.Sros_5863	6.905e-150	481.0	COG3502@1|root,COG3502@2|Bacteria,2H2JJ@201174|Actinobacteria,4EFJW@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF3866)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3866
TLS2_k127_4854723_5	443255.SCLAV_0855	4.861e-52	190.0	COG0545@1|root,COG0545@2|Bacteria,2IHQC@201174|Actinobacteria	201174|Actinobacteria	O	Peptidyl-prolyl cis-trans isomerase	fkbP	-	5.2.1.8	ko:K01802,ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
TLS2_k127_4854723_6	1283283.ATXA01000001_gene562	6.257e-50	190.0	COG0545@1|root,COG0545@2|Bacteria,2GJK2@201174|Actinobacteria,4ET6I@85013|Frankiales	201174|Actinobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	fkbB	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
TLS2_k127_4854723_1	1120950.KB892708_gene4431	6.928e-145	462.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4DPF1@85009|Propionibacteriales	201174|Actinobacteria	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
TLS2_k127_4859312_9	285535.JOEY01000019_gene2336	8.055e-05	46.0	COG1609@1|root,COG1609@2|Bacteria,2GK1X@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_4859312_2	358823.DF19_08485	9.129e-160	512.0	COG0673@1|root,COG0673@2|Bacteria,2GK0F@201174|Actinobacteria	201174|Actinobacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4859312_1	105422.BBPM01000001_gene4704	3.262e-173	551.0	COG1082@1|root,COG1082@2|Bacteria,2GK1S@201174|Actinobacteria	201174|Actinobacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS2_k127_4859312_7	1172188.KB911820_gene2557	1.64e-23	107.0	2EHZA@1|root,33BQS@2|Bacteria,2IJZ0@201174|Actinobacteria,4FGP6@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4859312_4	367299.JOEE01000003_gene2922	3.837e-110	376.0	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria,4FIAT@85021|Intrasporangiaceae	201174|Actinobacteria	E	Peptidase dimerisation domain	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_4859312_3	1133849.O3I_007265	1.262e-134	437.0	COG0388@1|root,COG0388@2|Bacteria,2H03Y@201174|Actinobacteria,4G2QK@85025|Nocardiaceae	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.5.1	ko:K01501	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
TLS2_k127_4859312_0	397278.JOJN01000007_gene3187	1.231e-191	608.0	COG1982@1|root,COG1982@2|Bacteria,2GJ31@201174|Actinobacteria,4DP2C@85009|Propionibacteriales	201174|Actinobacteria	E	Orn/Lys/Arg decarboxylase, C-terminal domain	-	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
TLS2_k127_4859312_8	1229780.BN381_40041	5.039e-19	95.0	2CK3K@1|root,32SBH@2|Bacteria,2IQJH@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Ion	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
TLS2_k127_4859312_6	1121924.ATWH01000011_gene403	9.137e-55	196.0	COG0346@1|root,COG0346@2|Bacteria,2IKTR@201174|Actinobacteria,4FPF8@85023|Microbacteriaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_4859312_5	1120958.AULD01000006_gene468	2.029e-96	329.0	COG0596@1|root,COG0596@2|Bacteria,2GJ4I@201174|Actinobacteria,4FPQV@85023|Microbacteriaceae	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_4859313_3	358823.DF19_08485	5.408e-148	476.0	COG0673@1|root,COG0673@2|Bacteria,2GK0F@201174|Actinobacteria	201174|Actinobacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4859313_5	526225.Gobs_2762	2.384e-125	411.0	COG1609@1|root,COG1609@2|Bacteria,2GK1X@201174|Actinobacteria,4ET1H@85013|Frankiales	201174|Actinobacteria	K	periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_4859313_10	500153.JOEK01000001_gene3635	1.058e-78	281.0	COG0730@1|root,COG0730@2|Bacteria,2GK5W@201174|Actinobacteria	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_4859313_9	358823.DF19_08455	3.826e-93	325.0	COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria	201174|Actinobacteria	C	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_4859313_11	526225.Gobs_2757	3.623e-53	189.0	COG1942@1|root,COG1942@2|Bacteria,2IMQ7@201174|Actinobacteria,4EVZI@85013|Frankiales	201174|Actinobacteria	S	Tautomerase enzyme	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase_2
TLS2_k127_4859313_4	351607.Acel_1810	9.205e-138	455.0	COG1082@1|root,COG1082@2|Bacteria,2GMU1@201174|Actinobacteria,4EUHF@85013|Frankiales	201174|Actinobacteria	G	PFAM Xylose isomerase domain protein TIM barrel	iolH	-	-	ko:K06605	-	-	-	-	ko00000	-	-	-	AP_endonuc_2
TLS2_k127_4859313_1	479431.Namu_4534	5.194e-152	487.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria,4ESB4@85013|Frankiales	201174|Actinobacteria	C	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose)	iolG	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_4859313_7	1120948.KB903243_gene2422	6.966e-121	398.0	COG1129@1|root,COG1129@2|Bacteria,2GJDV@201174|Actinobacteria,4E0W1@85010|Pseudonocardiales	201174|Actinobacteria	G	ATPases associated with a variety of cellular activities	iolTC	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TLS2_k127_4859313_2	526225.Gobs_2771	9.134e-152	489.0	COG1172@1|root,COG1172@2|Bacteria,2GM9E@201174|Actinobacteria,4ES5D@85013|Frankiales	201174|Actinobacteria	G	Belongs to the binding-protein-dependent transport system permease family	iolTB	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS2_k127_4859313_8	526225.Gobs_2772	2.141e-116	387.0	COG1879@1|root,COG1879@2|Bacteria,2GKIJ@201174|Actinobacteria,4ES2C@85013|Frankiales	201174|Actinobacteria	G	Monosaccharide ABC transporter substrate-binding protein, CUT2 family	iolTA	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Peripla_BP_4
TLS2_k127_4859313_6	443218.AS9A_3970	8.351e-124	404.0	COG1082@1|root,COG1082@2|Bacteria,2GJKJ@201174|Actinobacteria,235HH@1762|Mycobacteriaceae	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_4859313_0	1120949.KB903295_gene2354	1.256e-258	805.0	COG1012@1|root,COG1012@2|Bacteria,2GJI2@201174|Actinobacteria,4D8Q2@85008|Micromonosporales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_4874434_2	1449355.JQNR01000005_gene3406	2.967e-67	231.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	msiK	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
TLS2_k127_4874434_0	644283.Micau_0768	2.932e-144	472.0	COG1609@1|root,COG1609@2|Bacteria,2GJRG@201174|Actinobacteria,4DBCY@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator, LacI family	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	LacI,Peripla_BP_3
TLS2_k127_4874434_3	743718.Isova_1882	5.974e-51	185.0	COG2905@1|root,COG2905@2|Bacteria,2I3M3@201174|Actinobacteria,4F5M3@85017|Promicromonosporaceae	201174|Actinobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_4874434_1	1068980.ARVW01000001_gene6184	6.724e-91	314.0	COG4447@1|root,COG4447@2|Bacteria,2GMKN@201174|Actinobacteria,4EAJ9@85010|Pseudonocardiales	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4874434_5	1172185.KB911509_gene128	1.285e-08	59.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4FX7J@85025|Nocardiaceae	201174|Actinobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_4892183_2	1120950.KB892768_gene5291	8.354e-128	419.0	COG0477@1|root,COG0477@2|Bacteria,2GKY2@201174|Actinobacteria,4DQFD@85009|Propionibacteriales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4892183_0	1380356.JNIK01000016_gene3783	7.914e-174	551.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4EU92@85013|Frankiales	201174|Actinobacteria	S	Mo-co oxidoreductase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
TLS2_k127_4892183_7	1120950.KB892751_gene6774	4.328e-35	148.0	2CAFG@1|root,32ZDZ@2|Bacteria,2I800@201174|Actinobacteria,4DRHQ@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF3039)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3039
TLS2_k127_4892183_5	1306174.JODP01000005_gene1707	1.103e-61	227.0	COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the UPF0301 (AlgH) family	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
TLS2_k127_4892183_9	1120950.KB892751_gene6772	3.883e-14	85.0	2DSSV@1|root,33HAV@2|Bacteria,2GXP7@201174|Actinobacteria,4DWCK@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
TLS2_k127_4892183_3	2074.JNYD01000035_gene6700	1.344e-114	378.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4DZSI@85010|Pseudonocardiales	201174|Actinobacteria	E	TOBE domain	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
TLS2_k127_4892183_1	33898.JRHJ01000079_gene1277	2.206e-163	546.0	COG1178@1|root,COG1178@2|Bacteria,2GKPT@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
TLS2_k127_4892183_6	867845.KI911784_gene1842	1.818e-50	193.0	COG1840@1|root,COG1840@2|Bacteria,2G5QA@200795|Chloroflexi	200795|Chloroflexi	P	extracellular solute-binding protein, family 1	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
TLS2_k127_4892183_8	253839.SSNG_02362	2.631e-18	93.0	COG4243@1|root,COG4243@2|Bacteria,2GMVK@201174|Actinobacteria	201174|Actinobacteria	S	Vitamin K epoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
TLS2_k127_4892183_4	298654.FraEuI1c_1526	1.778e-79	290.0	COG2197@1|root,COG3899@1|root,COG2197@2|Bacteria,COG3899@2|Bacteria,2I5UU@201174|Actinobacteria,4EXD6@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_4892183_10	298654.FraEuI1c_1526	2.412e-09	69.0	COG2197@1|root,COG3899@1|root,COG2197@2|Bacteria,COG3899@2|Bacteria,2I5UU@201174|Actinobacteria,4EXD6@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_4905003_0	644283.Micau_4703	0.0	1501.0	COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria,4DABZ@85008|Micromonosporales	201174|Actinobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0004739,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016624,GO:0016903,GO:0030312,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046872,GO:0055114,GO:0071944,GO:1902494,GO:1990204	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS2_k127_4905003_1	103733.JNYO01000038_gene4136	1.496e-27	123.0	COG1846@1|root,COG1846@2|Bacteria,2IIW6@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_4907659_3	365528.KB891233_gene1766	2.819e-06	59.0	COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria,4ET3J@85013|Frankiales	201174|Actinobacteria	L	HNH endonuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_4907659_2	65497.JODV01000014_gene3315	6.941e-51	196.0	COG1533@1|root,COG1533@2|Bacteria,2GM31@201174|Actinobacteria,4DXBF@85010|Pseudonocardiales	201174|Actinobacteria	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_4907659_0	266940.Krad_3074	2e-323	1009.0	COG3280@1|root,COG3280@2|Bacteria,2GJTB@201174|Actinobacteria	201174|Actinobacteria	G	Malto-oligosyl trehalose synthase	treY	GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
TLS2_k127_4907659_1	743718.Isova_1748	1.462e-254	791.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,4F3Z4@85017|Promicromonosporaceae	201174|Actinobacteria	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS2_k127_490977_9	1120934.KB894423_gene2769	8.299e-67	244.0	COG5012@1|root,COG5012@2|Bacteria,2GKAY@201174|Actinobacteria,4E36B@85010|Pseudonocardiales	201174|Actinobacteria	S	cobalamin binding protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
TLS2_k127_490977_7	1120934.KB894423_gene2770	2.339e-106	374.0	COG2208@1|root,COG2208@2|Bacteria,2GKN8@201174|Actinobacteria,4DZ1T@85010|Pseudonocardiales	201174|Actinobacteria	KT	Serine phosphatase RsbU, regulator of sigma subunit	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,PAS,SpoIIE
TLS2_k127_490977_2	1120950.KB892707_gene4856	1.619e-140	454.0	COG2008@1|root,COG2008@2|Bacteria,2GMNV@201174|Actinobacteria,4DPQR@85009|Propionibacteriales	201174|Actinobacteria	E	Beta-eliminating lyase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_490977_11	471853.Bcav_0672	1.501e-64	230.0	COG1309@1|root,COG1309@2|Bacteria,2GYYS@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
TLS2_k127_490977_6	471853.Bcav_0673	2.418e-108	362.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_490977_10	935839.JAGJ01000012_gene3010	1.001e-66	252.0	COG0842@1|root,COG0842@2|Bacteria,2GIVW@201174|Actinobacteria,4F48M@85017|Promicromonosporaceae	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_490977_0	479432.Sros_2759	8.575e-165	526.0	COG2876@1|root,COG2876@2|Bacteria,2I3UA@201174|Actinobacteria,4EI1I@85012|Streptosporangiales	201174|Actinobacteria	E	NeuB family	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
TLS2_k127_490977_5	1120950.KB892707_gene4862	6.499e-112	369.0	COG0697@1|root,COG0697@2|Bacteria,2I8X5@201174|Actinobacteria,4DPV8@85009|Propionibacteriales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_490977_1	196162.Noca_3086	8.568e-160	526.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4DPC3@85009|Propionibacteriales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_490977_8	1283283.ATXA01000003_gene1617	7.643e-78	274.0	28QKY@1|root,2ZD2Q@2|Bacteria,2IM53@201174|Actinobacteria,4EU46@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_490977_3	1120950.KB892707_gene4866	3.651e-125	423.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4DN8X@85009|Propionibacteriales	201174|Actinobacteria	S	Reductase C-terminal	fprE	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
TLS2_k127_490977_14	710111.FraQA3DRAFT_6448	2.408e-31	135.0	2CPEY@1|root,32SIY@2|Bacteria,2I84R@201174|Actinobacteria,4ETKH@85013|Frankiales	201174|Actinobacteria	S	lycopene cyclase	crtY	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_490977_13	1048339.KB913029_gene4370	7.313e-36	146.0	2E9MI@1|root,333U6@2|Bacteria,2IMX9@201174|Actinobacteria,4ETA1@85013|Frankiales	201174|Actinobacteria	S	lycopene cyclase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_490977_4	1504319.GM45_0995	4.68e-112	370.0	COG1562@1|root,COG1562@2|Bacteria,2HFT6@201174|Actinobacteria,3UXMW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Squalene/phytoene synthase	-	-	-	-	-	-	-	-	-	-	-	-	SQS_PSY
TLS2_k127_490977_12	1306174.JODP01000009_gene6582	8.398e-60	209.0	COG1233@1|root,COG1233@2|Bacteria,2GJAV@201174|Actinobacteria	201174|Actinobacteria	Q	phytoene	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
TLS2_k127_4913761_0	1298863.AUEP01000008_gene1267	1.446e-233	738.0	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria,4DP8W@85009|Propionibacteriales	201174|Actinobacteria	G	ABC transporter, ATP-binding protein	rbsA	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
TLS2_k127_4913761_1	1122138.AQUZ01000037_gene5590	6.061e-81	274.0	COG1846@1|root,COG1940@1|root,COG1846@2|Bacteria,COG1940@2|Bacteria,2GJIE@201174|Actinobacteria,4DPBY@85009|Propionibacteriales	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,MarR_2,ROK
TLS2_k127_4922369_0	58123.JOFJ01000018_gene4244	1.165e-176	559.0	COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,4EJHQ@85012|Streptosporangiales	201174|Actinobacteria	S	Alcohol dehydrogenase GroES-like domain	adhA	-	1.1.1.1	ko:K00001,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_4922369_1	1095767.CAHD01000005_gene2429	3.532e-149	501.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria	201174|Actinobacteria	E	dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
TLS2_k127_4922369_2	1304865.JAGF01000001_gene96	2.349e-100	357.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria	201174|Actinobacteria	Q	Belongs to the long-chain O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,PAP2_3,WES_acyltransf
TLS2_k127_4922369_4	405948.SACE_5199	3.03e-83	284.0	COG1656@1|root,COG1656@2|Bacteria,2GMQR@201174|Actinobacteria,4E47S@85010|Pseudonocardiales	201174|Actinobacteria	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
TLS2_k127_4922369_6	397278.JOJN01000003_gene1800	1.928e-27	123.0	COG2357@1|root,COG4328@1|root,COG2357@2|Bacteria,COG4328@2|Bacteria,2GKF8@201174|Actinobacteria,4DPS6@85009|Propionibacteriales	201174|Actinobacteria	Q	Region found in RelA / SpoT proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF429,RelA_SpoT
TLS2_k127_4922369_5	1157638.KB892163_gene2751	1.056e-62	228.0	COG0220@1|root,COG0220@2|Bacteria,2GJ8R@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
TLS2_k127_4922369_3	1386089.N865_07305	3.451e-89	304.0	COG1808@1|root,COG1808@2|Bacteria,2HXYW@201174|Actinobacteria,4FINC@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
TLS2_k127_4924829_15	2045.KR76_22975	2.166e-71	251.0	COG1051@1|root,COG2062@1|root,COG1051@2|Bacteria,COG2062@2|Bacteria,2I2N2@201174|Actinobacteria,4DWX8@85009|Propionibacteriales	201174|Actinobacteria	FT	Phosphoglycerate mutase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
TLS2_k127_4924829_4	397278.JOJN01000003_gene2110	3.13e-124	409.0	COG2072@1|root,COG2072@2|Bacteria,2GK95@201174|Actinobacteria,4DMYB@85009|Propionibacteriales	201174|Actinobacteria	P	Flavin-binding monooxygenase-like	arsO	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS2_k127_4924829_3	1146883.BLASA_4538	4.029e-126	413.0	COG0226@1|root,COG0226@2|Bacteria,2GMY1@201174|Actinobacteria	201174|Actinobacteria	P	phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	HSP70,PBP_like,PBP_like_2
TLS2_k127_4924829_5	1146883.BLASA_4537	4.352e-122	400.0	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria	201174|Actinobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS2_k127_4924829_10	2002.JOEQ01000048_gene7446	2.49e-93	329.0	COG0581@1|root,COG0581@2|Bacteria,2I2F2@201174|Actinobacteria,4EN8Q@85012|Streptosporangiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS2_k127_4924829_6	1146883.BLASA_4535	1.627e-118	405.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4ERC8@85013|Frankiales	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TLS2_k127_4924829_14	909613.UO65_2101	1.609e-76	268.0	COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,2IB1N@201174|Actinobacteria,4E6RW@85010|Pseudonocardiales	201174|Actinobacteria	KT	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,LMWPc
TLS2_k127_4924829_7	931627.MycrhDRAFT_0383	2.266e-104	352.0	COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria,2352Q@1762|Mycobacteriaceae	201174|Actinobacteria	T	Low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS2_k127_4924829_20	479431.Namu_2554	4.021e-24	115.0	COG0526@1|root,COG0526@2|Bacteria,2GUBI@201174|Actinobacteria	201174|Actinobacteria	CO	redox-active disulfide protein 2	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
TLS2_k127_4924829_1	479431.Namu_2555	8.918e-173	549.0	COG0701@1|root,COG0701@2|Bacteria	2|Bacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
TLS2_k127_4924829_17	1304865.JAGF01000001_gene3289	2.018e-29	123.0	COG0640@1|root,COG0640@2|Bacteria,2GQU5@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein, ArsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
TLS2_k127_4924829_13	367299.JOEE01000006_gene718	6.247e-84	309.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,4FE5H@85021|Intrasporangiaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS2_k127_4924829_8	644283.Micau_5008	3.218e-102	338.0	COG0204@1|root,COG0204@2|Bacteria,2GKM6@201174|Actinobacteria,4D9A6@85008|Micromonosporales	201174|Actinobacteria	I	Phospholipid glycerol acyltransferase	plsC1	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TLS2_k127_4924829_2	1123319.AUBE01000002_gene1627	2.462e-160	515.0	COG1502@1|root,COG1502@2|Bacteria,2GM0P@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
TLS2_k127_4924829_19	68219.JNXI01000002_gene4260	1.929e-25	119.0	COG2334@1|root,COG2334@2|Bacteria,2GNZM@201174|Actinobacteria	201174|Actinobacteria	S	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_4924829_11	1172188.KB911821_gene1381	1.814e-92	313.0	COG1028@1|root,COG1028@2|Bacteria,2GKW9@201174|Actinobacteria,4FIQI@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_4924829_0	1209984.BN978_01542	1.545e-204	659.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,236K7@1762|Mycobacteriaceae	201174|Actinobacteria	P	Sulfate transporter	-	GO:0000103,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008272,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0019001,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
TLS2_k127_4924829_18	1184609.KILIM_049_00280	5.073e-28	124.0	2E8R3@1|root,33322@2|Bacteria,2I97P@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4924829_12	1150864.MILUP08_42295	6.654e-88	300.0	COG1938@1|root,COG1938@2|Bacteria,2I2N7@201174|Actinobacteria,4DBJV@85008|Micromonosporales	201174|Actinobacteria	S	PAC2 family	pac	-	-	-	-	-	-	-	-	-	-	-	PAC2
TLS2_k127_4924829_16	1095767.CAHD01000068_gene3061	2.89e-69	239.0	COG2606@1|root,COG2606@2|Bacteria,2IIIW@201174|Actinobacteria,4F1D0@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM YbaK prolyl-tRNA synthetase associated region	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
TLS2_k127_4924829_9	2074.JNYD01000005_gene3238	6.154e-96	326.0	COG1524@1|root,COG1524@2|Bacteria,2HH0Q@201174|Actinobacteria	201174|Actinobacteria	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_4_2,Phosphodiest
TLS2_k127_4938876_5	512565.AMIS_11980	7.049e-51	188.0	COG4721@1|root,COG4721@2|Bacteria,2IDAN@201174|Actinobacteria,4D9S6@85008|Micromonosporales	201174|Actinobacteria	S	ABC-type cobalt transport system, permease component	ykoE	-	-	ko:K16925	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.30	-	-	ABC_cobalt
TLS2_k127_4938876_1	356851.JOAN01000031_gene5301	9.171e-163	532.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4D9CY@85008|Micromonosporales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	ykoD	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,CbiQ
TLS2_k127_4938876_4	356851.JOAN01000031_gene5300	2.147e-65	245.0	COG0619@1|root,COG0619@2|Bacteria,2IDC9@201174|Actinobacteria,4D9JP@85008|Micromonosporales	201174|Actinobacteria	P	cobalt transport	ykoC	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
TLS2_k127_4938876_6	1394178.AWOO02000057_gene728	2.493e-44	166.0	COG1846@1|root,COG1846@2|Bacteria,2IJHQ@201174|Actinobacteria,4EJU5@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS2_k127_4938876_0	1123322.KB904635_gene2478	6.587e-165	526.0	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria	201174|Actinobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
TLS2_k127_4938876_8	1120950.KB892823_gene486	3.302e-20	98.0	COG1826@1|root,COG1826@2|Bacteria,2IR0U@201174|Actinobacteria,4DRKC@85009|Propionibacteriales	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	GO:0008150,GO:0040007	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS2_k127_4938876_2	446469.Sked_25880	8.317e-100	357.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria	201174|Actinobacteria	O	Peptidase s1 and s6 chymotrypsin hap	sprI	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_4938876_7	479435.Kfla_5479	5.092e-37	159.0	COG3026@1|root,COG3026@2|Bacteria,2IRR9@201174|Actinobacteria,4DSGE@85009|Propionibacteriales	201174|Actinobacteria	T	antisigma factor binding	-	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB
TLS2_k127_4938876_9	479435.Kfla_5480	6.038e-17	91.0	COG5662@1|root,COG5662@2|Bacteria,2GKPI@201174|Actinobacteria	201174|Actinobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_4938876_3	471852.Tcur_1183	1.638e-69	237.0	COG1595@1|root,COG1595@2|Bacteria,2GK4C@201174|Actinobacteria,4EHBC@85012|Streptosporangiales	201174|Actinobacteria	K	RNA polymerase sigma factor, sigma-70 family	sigE	GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4954880_2	479432.Sros_5640	1.334e-77	270.0	COG1597@1|root,COG1597@2|Bacteria,2GNTZ@201174|Actinobacteria,4EJ1P@85012|Streptosporangiales	201174|Actinobacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS2_k127_4954880_0	1229203.KI301992_gene2264	7.284e-229	715.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,3UWF4@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
TLS2_k127_4954880_1	1169161.KB897732_gene96	2.825e-80	297.0	COG3568@1|root,COG3568@2|Bacteria,2IGGC@201174|Actinobacteria	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_4977247_0	1380370.JIBA01000014_gene1941	0.0	1200.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,4FHGP@85021|Intrasporangiaceae	201174|Actinobacteria	P	Sulfatase	atsD	GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004065,GO:0004098,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005783,GO:0005788,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006687,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008150,GO:0008152,GO:0008484,GO:0009987,GO:0012505,GO:0016192,GO:0016787,GO:0016788,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034774,GO:0035578,GO:0036230,GO:0042119,GO:0042582,GO:0043167,GO:0043169,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044255,GO:0044422,GO:0044424,GO:0044432,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046872,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0071704,GO:0097708,GO:0099503,GO:1901135,GO:1901564,GO:1903509	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
TLS2_k127_4977247_2	685727.REQ_18030	1.346e-142	459.0	COG1262@1|root,COG1262@2|Bacteria,2GK9Q@201174|Actinobacteria,4FW4U@85025|Nocardiaceae	201174|Actinobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TLS2_k127_4977247_6	1306174.JODP01000005_gene1428	0.0001595	51.0	2DMRX@1|root,32T9D@2|Bacteria,2IQHF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4977247_4	1464048.JNZS01000010_gene5116	8.455e-56	207.0	COG1720@1|root,COG1720@2|Bacteria,2IKKT@201174|Actinobacteria,4DE3M@85008|Micromonosporales	201174|Actinobacteria	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
TLS2_k127_4977247_1	1380393.JHVP01000003_gene1104	8.275e-188	603.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4ERPW@85013|Frankiales	2|Bacteria	KOT	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
TLS2_k127_4977247_3	1385520.N802_13870	3.054e-116	398.0	COG0151@1|root,COG0151@2|Bacteria,2I62N@201174|Actinobacteria,4FE38@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the GarS family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4977247_5	67352.JODS01000001_gene513	1.4e-35	141.0	COG0604@1|root,COG0604@2|Bacteria,2GIWC@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
TLS2_k127_4984986_10	390989.JOEG01000009_gene926	1.172e-48	177.0	COG0834@1|root,COG0834@2|Bacteria,2GN3G@201174|Actinobacteria,4D8FU@85008|Micromonosporales	201174|Actinobacteria	ET	ABC-type amino acid transport signal transduction systems, periplasmic component domain	-	-	-	ko:K02030,ko:K02424,ko:K17073	ko02010,map02010	M00234,M00236,M00589	-	-	ko00000,ko00001,ko00002,ko02000,ko02035	3.A.1.3,3.A.1.3.10,3.A.1.3.14,3.A.1.3.20	-	-	SBP_bac_3
TLS2_k127_4984986_2	318424.EU78_21570	3.425e-107	354.0	COG0765@1|root,COG0765@2|Bacteria,2GM0I@201174|Actinobacteria,23CFP@1762|Mycobacteriaceae	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
TLS2_k127_4984986_4	103733.JNYO01000004_gene7673	1.348e-105	367.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4E109@85010|Pseudonocardiales	201174|Actinobacteria	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	3.6.3.21	ko:K02028,ko:K02029	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
TLS2_k127_4984986_9	1123024.AUII01000006_gene4608	1.153e-54	201.0	COG3247@1|root,COG3247@2|Bacteria	2|Bacteria	U	response to pH	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
TLS2_k127_4984986_5	479435.Kfla_3101	1.24e-92	329.0	COG0789@1|root,COG0789@2|Bacteria,2H5GI@201174|Actinobacteria,4DSHX@85009|Propionibacteriales	201174|Actinobacteria	K	TipAS antibiotic-recognition domain	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TipAS
TLS2_k127_4984986_7	1120950.KB892812_gene7084	1.55e-62	219.0	COG0590@1|root,COG0590@2|Bacteria,2INAI@201174|Actinobacteria,4DQQ8@85009|Propionibacteriales	201174|Actinobacteria	FJ	MafB19-like deaminase	-	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
TLS2_k127_4984986_1	1120950.KB892812_gene7083	6.711e-130	426.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4DRW9@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_4984986_3	1122622.ATWJ01000014_gene408	7.668e-107	366.0	COG2909@1|root,COG2909@2|Bacteria,2I3S2@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_4984986_11	366394.Smed_5244	2.839e-48	183.0	COG0454@1|root,COG0456@2|Bacteria,1RDNX@1224|Proteobacteria,2U70R@28211|Alphaproteobacteria,4BDT4@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
TLS2_k127_4984986_8	1122619.KB892311_gene2171	7.152e-57	209.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2VH8H@28216|Betaproteobacteria,3T8AF@506|Alcaligenaceae	28216|Betaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_4984986_0	196162.Noca_3653	1.916e-153	499.0	COG2070@1|root,COG2070@2|Bacteria,2I93H@201174|Actinobacteria	201174|Actinobacteria	S	2-Nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
TLS2_k127_4984986_6	266117.Rxyl_0494	4.907e-79	276.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria,4CPGH@84995|Rubrobacteria	201174|Actinobacteria	C	Aldo/keto reductase family	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_4984986_12	926560.KE387025_gene4132	5.094e-37	141.0	COG2085@1|root,COG2085@2|Bacteria,1WMWM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	NADP oxidoreductase coenzyme F420-dependent	-	-	-	-	-	-	-	-	-	-	-	-	F420_oxidored
TLS2_k127_5002047_4	1068978.AMETH_6906	8.467e-11	65.0	2EGRW@1|root,33AI2@2|Bacteria,2IQF3@201174|Actinobacteria,4E7DF@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF3073)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3073
TLS2_k127_5002047_0	1123320.KB889702_gene9458	1.802e-162	519.0	COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	vdh	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.4.1.23	ko:K00271	ko00280,ko01100,ko01110,ko01130,map00280,map01100,map01110,map01130	-	R01212,R01434	RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS2_k127_5002047_1	1123320.KB889702_gene9457	1.377e-72	254.0	2BPHM@1|root,32IA4@2|Bacteria,2GM2J@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5002047_3	1003195.SCAT_3357	4.623e-30	123.0	COG2452@1|root,COG2452@2|Bacteria,2GQJ9@201174|Actinobacteria	201174|Actinobacteria	L	TIGRFAM DNA binding domain protein, excisionase family	bldC	-	-	-	-	-	-	-	-	-	-	-	HTH_17
TLS2_k127_5002047_2	211114.JOEF01000001_gene7101	1.559e-40	154.0	COG3336@1|root,COG3336@2|Bacteria,2GKIR@201174|Actinobacteria,4DXS0@85010|Pseudonocardiales	201174|Actinobacteria	P	Copper resistance	copD	-	-	ko:K02351,ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	Caa3_CtaG,CopD
TLS2_k127_5040331_7	1122138.AQUZ01000074_gene7342	5.222e-15	87.0	2ETNC@1|root,33M63@2|Bacteria,2GKI3@201174|Actinobacteria,4DS5B@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5040331_2	469371.Tbis_3184	8.172e-78	265.0	COG1670@1|root,COG1670@2|Bacteria,2HAFI@201174|Actinobacteria,4DY57@85010|Pseudonocardiales	201174|Actinobacteria	J	PFAM Acetyltransferase (GNAT) family	rimJ	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS2_k127_5040331_3	67352.JODS01000007_gene4579	1.81e-69	248.0	COG0521@1|root,COG0521@2|Bacteria,2II28@201174|Actinobacteria	201174|Actinobacteria	H	Molybdenum cofactor synthesis	mog	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoaE
TLS2_k127_5040331_6	1380356.JNIK01000018_gene618	4.321e-59	227.0	COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,4ESM0@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
TLS2_k127_5040331_0	351607.Acel_0167	2.375e-163	524.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4ERWC@85013|Frankiales	201174|Actinobacteria	H	MoeA domain protein domain I and II	moeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1,2.7.7.9	ko:K00963,ko:K03750	ko00040,ko00052,ko00500,ko00520,ko00790,ko01100,ko01130,map00040,map00052,map00500,map00520,map00790,map01100,map01130	M00129,M00361,M00362,M00549	R00289,R09735	RC00002,RC03462	ko00000,ko00001,ko00002,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS2_k127_5040331_1	1120950.KB892750_gene6888	1.422e-142	467.0	COG1210@1|root,COG1210@2|Bacteria,2I2EW@201174|Actinobacteria	201174|Actinobacteria	M	Utp--glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_5040331_5	1120950.KB892750_gene6887	3.091e-61	216.0	COG0212@1|root,COG0212@2|Bacteria,2IKWR@201174|Actinobacteria,4DR3Y@85009|Propionibacteriales	201174|Actinobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	ygfA	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
TLS2_k127_5040331_4	1122611.KB903974_gene2934	9.946e-65	226.0	COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4EFUH@85012|Streptosporangiales	201174|Actinobacteria	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS2_k127_5064447_1	1298863.AUEP01000001_gene779	1.311e-90	304.0	COG2197@1|root,COG2197@2|Bacteria,2IIDD@201174|Actinobacteria,4DWNU@85009|Propionibacteriales	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_5064447_3	1190603.AJYD01000037_gene1337	2.046e-16	93.0	COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,1RSMY@1236|Gammaproteobacteria,1XXKV@135623|Vibrionales	135623|Vibrionales	M	Secreted and surface protein containing fasciclin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
TLS2_k127_5064447_2	405948.SACE_6076	6.227e-67	237.0	COG0572@1|root,COG0572@2|Bacteria,2I9H4@201174|Actinobacteria,4DXR2@85010|Pseudonocardiales	201174|Actinobacteria	F	Fructose transport system kinase	-	-	-	-	-	-	-	-	-	-	-	-	PRK
TLS2_k127_5064447_0	2074.JNYD01000023_gene1340	1.398e-91	322.0	COG2120@1|root,COG2120@2|Bacteria,2IDT2@201174|Actinobacteria,4EBAF@85010|Pseudonocardiales	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K22135	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS2_k127_5117391_4	1043493.BBLU01000021_gene657	6.421e-66	233.0	COG1832@1|root,COG1832@2|Bacteria,2IJYY@201174|Actinobacteria	201174|Actinobacteria	S	PFAM CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
TLS2_k127_5117391_6	40571.JOEA01000037_gene6785	8.626e-47	176.0	2EQJT@1|root,33I5T@2|Bacteria,2IDGV@201174|Actinobacteria,4E5QY@85010|Pseudonocardiales	201174|Actinobacteria	S	AbiEi antitoxin C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_1
TLS2_k127_5117391_5	345341.KUTG_05930	1.432e-49	185.0	COG2253@1|root,COG2253@2|Bacteria,2H4TG@201174|Actinobacteria,4E7SN@85010|Pseudonocardiales	201174|Actinobacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
TLS2_k127_5117391_0	443218.AS9A_4549	2.054e-265	833.0	COG0025@1|root,COG0025@2|Bacteria,2GIUT@201174|Actinobacteria,234N8@1762|Mycobacteriaceae	201174|Actinobacteria	P	Sodium hydrogen exchanger	yjcE	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042592,GO:0044464,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098719,GO:0098739,GO:0098771,GO:0099516,GO:0099587,GO:1902600	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
TLS2_k127_5117391_7	1463900.JOIX01000005_gene1274	7.719e-44	162.0	COG3602@1|root,COG3602@2|Bacteria,2IM16@201174|Actinobacteria	201174|Actinobacteria	S	ACT domain	-	-	-	ko:K09964	-	-	-	-	ko00000	-	-	-	ACT_3,ACT_7,Acetyltransf_1
TLS2_k127_5117391_3	1120950.KB892770_gene1377	3.451e-88	298.0	COG1414@1|root,COG1414@2|Bacteria,2GP0G@201174|Actinobacteria,4DTSQ@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS2_k127_5117391_2	1120949.KB903294_gene3949	2.92e-173	549.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,4DM3N@85008|Micromonosporales	201174|Actinobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS2_k127_5117391_1	196162.Noca_3770	1.981e-173	562.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4DU4Q@85009|Propionibacteriales	201174|Actinobacteria	C	Transketolase, pyrimidine binding domain	acoB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_5117391_8	196162.Noca_3771	8.792e-21	106.0	COG0508@1|root,COG0508@2|Bacteria,2GS20@201174|Actinobacteria	201174|Actinobacteria	C	PFAM Biotin lipoyl attachment	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
TLS2_k127_5139891_4	661367.LLO_2456	1.294e-12	83.0	COG3177@1|root,COG3177@2|Bacteria,1R1EC@1224|Proteobacteria,1SMQ4@1236|Gammaproteobacteria,1JEYH@118969|Legionellales	118969|Legionellales	S	Zeta toxin	-	-	-	-	-	-	-	-	-	-	-	-	Zeta_toxin
TLS2_k127_5139891_1	263358.VAB18032_03475	3.826e-66	260.0	COG3170@1|root,COG3468@1|root,COG4223@1|root,COG3170@2|Bacteria,COG3468@2|Bacteria,COG4223@2|Bacteria,2I5PC@201174|Actinobacteria,4DMNZ@85008|Micromonosporales	201174|Actinobacteria	MNU	Calpain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Gln_amidase,Peptidase_C2,YwqJ-deaminase
TLS2_k127_5139891_3	68170.KL590484_gene7728	1.346e-15	93.0	COG3266@1|root,COG3266@2|Bacteria,2IB0P@201174|Actinobacteria	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5139891_0	106370.Francci3_2841	2.904e-66	260.0	COG4185@1|root,COG4185@2|Bacteria	2|Bacteria	-	-	-	-	2.7.1.176	ko:K16214	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Zeta_toxin
TLS2_k127_5139891_2	1288083.AUKR01000010_gene326	3.543e-19	105.0	COG3266@1|root,COG3266@2|Bacteria,2IB0P@201174|Actinobacteria	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_517986_6	1118058.CAGY01000001_gene149	1.222e-09	59.0	2ASDQ@1|root,31HT6@2|Bacteria,2HMBW@201174|Actinobacteria,4D6R3@85005|Actinomycetales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_517986_2	882083.SacmaDRAFT_5078	3.639e-155	502.0	COG0025@1|root,COG0025@2|Bacteria,2I37Q@201174|Actinobacteria,4DYM3@85010|Pseudonocardiales	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS2_k127_517986_5	351607.Acel_0113	6.298e-78	276.0	COG0477@1|root,COG2814@2|Bacteria,2IBR1@201174|Actinobacteria,4ESXS@85013|Frankiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_517986_4	471853.Bcav_3528	1.033e-98	336.0	COG1162@1|root,COG1162@2|Bacteria,2GMDX@201174|Actinobacteria	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
TLS2_k127_517986_3	1122138.AQUZ01000001_gene1516	1.725e-111	372.0	COG1295@1|root,COG1295@2|Bacteria,2GM6P@201174|Actinobacteria,4DN3S@85009|Propionibacteriales	201174|Actinobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_517986_1	134676.ACPL_5170	6.041e-206	655.0	COG1960@1|root,COG1960@2|Bacteria,2GJHM@201174|Actinobacteria,4D9D4@85008|Micromonosporales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	aidB	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
TLS2_k127_517986_0	219305.MCAG_01848	1.36e-260	813.0	COG0155@1|root,COG0155@2|Bacteria,2GJRN@201174|Actinobacteria,4DAJ2@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	sirA	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016002,GO:0016053,GO:0016491,GO:0016667,GO:0016673,GO:0019344,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.7.7.1,1.8.7.1	ko:K00366,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
TLS2_k127_5212429_20	561175.KB894093_gene4406	1.947e-21	108.0	COG0713@1|root,COG0713@2|Bacteria,2IHNW@201174|Actinobacteria,4EJV4@85012|Streptosporangiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK2	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS2_k127_5212429_18	1120950.KB892779_gene934	1.616e-54	197.0	COG0839@1|root,COG0839@2|Bacteria,2GJB7@201174|Actinobacteria,4DV5E@85009|Propionibacteriales	201174|Actinobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	nuoJ2	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS2_k127_5212429_15	1463856.JOHY01000030_gene2876	1.416e-86	289.0	COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI2	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
TLS2_k127_5212429_9	1120950.KB892779_gene936	2.867e-151	491.0	COG1005@1|root,COG1005@2|Bacteria,2GN3R@201174|Actinobacteria,4DU89@85009|Propionibacteriales	201174|Actinobacteria	C	NADH dehydrogenase	nuoH2	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS2_k127_5212429_17	479435.Kfla_6246	4.281e-58	221.0	COG0852@1|root,COG0852@2|Bacteria,2GNVP@201174|Actinobacteria,4DRTG@85009|Propionibacteriales	201174|Actinobacteria	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	nuoC2	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TLS2_k127_5212429_12	1906.SFRA_23285	4.157e-99	333.0	COG0377@1|root,COG0377@2|Bacteria,2GJP5@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB2	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TLS2_k127_5212429_21	3880.AES88242	1.485e-16	86.0	COG0377@1|root,COG0838@1|root,KOG1687@2759|Eukaryota,KOG4662@2759|Eukaryota,37QTD@33090|Viridiplantae,3GHED@35493|Streptophyta	35493|Streptophyta	C	NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient	ndhK	-	1.6.5.3	ko:K05574,ko:K05582	ko00190,ko01100,map00190,map01100	M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	-	-	-	Complex1_30kDa,Oxidored_q4,Oxidored_q6
TLS2_k127_5212429_1	1348663.KCH_44750	0.0	1023.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,2M0RC@2063|Kitasatospora	201174|Actinobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
TLS2_k127_5212429_8	1157637.KB892096_gene989	3.058e-159	533.0	COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria	201174|Actinobacteria	C	Ferredoxin oxidoreductase	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
TLS2_k127_5212429_11	397278.JOJN01000002_gene306	4.662e-113	372.0	COG2962@1|root,COG2962@2|Bacteria,2GKCP@201174|Actinobacteria,4DN8G@85009|Propionibacteriales	201174|Actinobacteria	S	EamA-like transporter family	rarD	-	-	ko:K05786	-	-	-	-	ko00000,ko02000	2.A.7.7	-	-	EamA
TLS2_k127_5212429_10	351607.Acel_0281	6.892e-134	441.0	COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4ERU8@85013|Frankiales	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	hepT	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_5212429_4	1120950.KB892779_gene958	3.41e-204	654.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4DNIM@85009|Propionibacteriales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_5212429_5	1122138.AQUZ01000056_gene6951	5.501e-166	560.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4DPXE@85009|Propionibacteriales	201174|Actinobacteria	C	Proton-conducting membrane transporter	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_5212429_2	1120950.KB892779_gene960	1.677e-271	849.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4DP65@85009|Propionibacteriales	201174|Actinobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TLS2_k127_5212429_19	935866.JAER01000064_gene3684	1.059e-38	146.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria,4DQZ5@85009|Propionibacteriales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS2_k127_5212429_16	1048339.KB913029_gene2585	3.353e-73	258.0	COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria,4ESIY@85013|Frankiales	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS2_k127_5212429_14	1120950.KB892779_gene963	1.693e-93	314.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4DP1W@85009|Propionibacteriales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.5.3	ko:K00338,ko:K12143	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3153	Fer4
TLS2_k127_5212429_7	1123320.KB889574_gene5654	3.014e-163	548.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3152	Fer4,NADHdh
TLS2_k127_5212429_0	1120950.KB892779_gene965	0.0	1129.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,4DNGW@85009|Propionibacteriales	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	nuoG	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
TLS2_k127_5212429_3	479433.Caci_7686	2.571e-232	741.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
TLS2_k127_5212429_13	1120950.KB892779_gene967	1.056e-93	321.0	COG1905@1|root,COG1905@2|Bacteria,2GKG0@201174|Actinobacteria,4DN2R@85009|Propionibacteriales	201174|Actinobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
TLS2_k127_5212429_6	1172181.KB911716_gene3732	8.634e-165	521.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS2_k127_5233132_2	1048339.KB913029_gene4927	1.203e-15	78.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4ERDU@85013|Frankiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
TLS2_k127_5233132_1	479435.Kfla_2119	1.038e-146	477.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4DNAW@85009|Propionibacteriales	201174|Actinobacteria	H	MoeA domain protein domain I and II	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS2_k127_5233132_0	1123024.AUII01000035_gene1217	1.51e-260	814.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,2GJC3@201174|Actinobacteria,4DXU7@85010|Pseudonocardiales	201174|Actinobacteria	H	TIGRFAM molybdenum cofactor synthesis domain	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
TLS2_k127_5249005_2	465515.Mlut_02360	1.021e-10	74.0	COG2852@1|root,COG2852@2|Bacteria,2GNZQ@201174|Actinobacteria,1W99S@1268|Micrococcaceae	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
TLS2_k127_5249005_0	196162.Noca_0778	1.349e-174	561.0	COG0415@1|root,COG0415@2|Bacteria,2GJXU@201174|Actinobacteria,4DNC6@85009|Propionibacteriales	201174|Actinobacteria	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
TLS2_k127_5249005_1	1463825.JNXC01000003_gene3926	4.698e-67	237.0	COG1192@1|root,COG1192@2|Bacteria,2H4UC@201174|Actinobacteria,4DZB6@85010|Pseudonocardiales	201174|Actinobacteria	D	involved in chromosome partitioning	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
TLS2_k127_5305779_1	1120950.KB892774_gene1268	5.146e-130	432.0	COG1408@1|root,COG1408@2|Bacteria,2GM8M@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
TLS2_k127_5305779_3	419947.MRA_1572	1.03e-28	116.0	COG5450@1|root,COG5450@2|Bacteria,2GTYZ@201174|Actinobacteria,23BQF@1762|Mycobacteriaceae	201174|Actinobacteria	K	Bacterial antitoxin of type II TA system, VapB	-	GO:0006417,GO:0008150,GO:0009605,GO:0009607,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0040008,GO:0043207,GO:0044403,GO:0044419,GO:0045727,GO:0045927,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:2000112	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
TLS2_k127_5305779_2	1298860.AUEM01000001_gene1305	2.121e-36	142.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	vapC	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0040008,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0071704,GO:0075136,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
TLS2_k127_5305779_6	1463855.JOHV01000018_gene3685	6.74e-09	64.0	2EKQH@1|root,342I4@2|Bacteria,2IIWV@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5305779_4	106370.Francci3_2794	3.211e-21	106.0	COG2372@1|root,COG2372@2|Bacteria,2GMKG@201174|Actinobacteria,4EWM7@85013|Frankiales	201174|Actinobacteria	S	copper resistance protein	-	-	-	ko:K07156,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC,CopD
TLS2_k127_5305779_0	561175.KB894094_gene1520	2.882e-157	520.0	COG1276@1|root,COG3336@1|root,COG1276@2|Bacteria,COG3336@2|Bacteria,2GKIR@201174|Actinobacteria,4EGUX@85012|Streptosporangiales	201174|Actinobacteria	P	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	copD	GO:0008150,GO:0040007	-	ko:K02351,ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	Caa3_CtaG,CopD
TLS2_k127_5305779_5	479431.Namu_1458	8.412e-16	79.0	COG0346@1|root,COG0346@2|Bacteria,2GTQJ@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_5305779_7	28444.JODQ01000006_gene618	6.95e-06	52.0	28JAE@1|root,2Z957@2|Bacteria,2I3IM@201174|Actinobacteria,4EJIB@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_4
TLS2_k127_5361852_4	479435.Kfla_5999	3.784e-106	362.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4DQRB@85009|Propionibacteriales	201174|Actinobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
TLS2_k127_5361852_1	1298863.AUEP01000002_gene1425	1.164e-303	942.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,4DN8W@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
TLS2_k127_5361852_5	469371.Tbis_0645	6.671e-71	247.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria,4E1KZ@85010|Pseudonocardiales	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_5361852_0	471852.Tcur_4235	0.0	1071.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4EHPP@85012|Streptosporangiales	201174|Actinobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_5361852_3	1211815.CBYP010000052_gene768	7.367e-107	381.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4ERPZ@85013|Frankiales	201174|Actinobacteria	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	cutM	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_5361852_6	1214242.B446_32855	1.73e-54	212.0	COG3427@1|root,COG3427@2|Bacteria,2GKTQ@201174|Actinobacteria	201174|Actinobacteria	S	carbon monoxide dehydrogenase subunit G	-	-	-	-	-	-	-	-	-	-	-	-	COXG
TLS2_k127_5361852_10	146922.JOFU01000011_gene1259	1.085e-24	113.0	2EA6A@1|root,334B4@2|Bacteria,2II4E@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4439)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4439
TLS2_k127_5361852_7	1245475.ANAE01000075_gene2816	7.929e-47	175.0	COG0779@1|root,COG0779@2|Bacteria,2I9BT@201174|Actinobacteria,4EJF1@85012|Streptosporangiales	201174|Actinobacteria	S	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
TLS2_k127_5361852_2	1120950.KB892747_gene3693	5.231e-168	532.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4DN47@85009|Propionibacteriales	201174|Actinobacteria	K	Participates in both transcription termination and antitermination	nusA	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
TLS2_k127_5361852_9	1214242.B446_26695	1.555e-27	116.0	COG2740@1|root,COG2740@2|Bacteria,2GQH0@201174|Actinobacteria	201174|Actinobacteria	K	nucleic-acid-binding protein implicated in transcription termination	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
TLS2_k127_5361852_8	593907.Celgi_2079	5.7e-28	119.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4F0Z9@85016|Cellulomonadaceae	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
TLS2_k127_5369001_1	397278.JOJN01000017_gene2552	6.578e-156	507.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4DNEV@85009|Propionibacteriales	201174|Actinobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_5369001_4	469371.Tbis_1351	4.169e-78	265.0	COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria,4DZ0J@85010|Pseudonocardiales	201174|Actinobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
TLS2_k127_5369001_5	1894.JOER01000023_gene7381	7.332e-63	222.0	COG1395@1|root,COG1395@2|Bacteria,2GVFR@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	bldD	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
TLS2_k127_5369001_7	479435.Kfla_4348	6.616e-55	195.0	COG0781@1|root,COG0781@2|Bacteria,2IM3D@201174|Actinobacteria,4DR4N@85009|Propionibacteriales	201174|Actinobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	GO:0008150,GO:0040007	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
TLS2_k127_5369001_3	1048339.KB913029_gene3969	2.437e-95	315.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4ERK9@85013|Frankiales	201174|Actinobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TLS2_k127_5369001_2	1123320.KB889665_gene1418	1.396e-118	391.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the peptidase M24B family	pepQ	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
TLS2_k127_5369001_6	1048339.KB913029_gene3966	1.422e-58	220.0	COG0757@1|root,COG0757@2|Bacteria,2IMBY@201174|Actinobacteria,4ESSK@85013|Frankiales	201174|Actinobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	GO:0003674,GO:0003824,GO:0003855,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
TLS2_k127_5369001_0	266940.Krad_3013	6.521e-158	509.0	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
TLS2_k127_5369001_8	351607.Acel_1308	5.412e-26	108.0	COG0703@1|root,COG0703@2|Bacteria,2GRFW@201174|Actinobacteria,4ESVA@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
TLS2_k127_5384375_13	1298863.AUEP01000002_gene1538	5.837e-57	199.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria,4DND0@85009|Propionibacteriales	201174|Actinobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS2_k127_5384375_14	1435356.Y013_05745	3.209e-33	140.0	COG1589@1|root,COG1589@2|Bacteria,2H4A4@201174|Actinobacteria,4FVIV@85025|Nocardiaceae	201174|Actinobacteria	M	Cell division protein FtsQ	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
TLS2_k127_5384375_1	1048339.KB913029_gene4575	8.502e-193	614.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4ERUC@85013|Frankiales	201174|Actinobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_5384375_9	1463845.JOIG01000007_gene741	7.289e-135	457.0	COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria	201174|Actinobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
TLS2_k127_5384375_7	1122138.AQUZ01000010_gene5214	4.795e-139	475.0	COG0772@1|root,COG0772@2|Bacteria,2GKXP@201174|Actinobacteria	201174|Actinobacteria	D	Belongs to the SEDS family	ftsW	GO:0008150,GO:0040007	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28	-	FTSW_RODA_SPOVE
TLS2_k127_5384375_0	1120950.KB892707_gene4888	9.5e-199	634.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4DNTV@85009|Propionibacteriales	201174|Actinobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2155c	AlaDh_PNT_C,Mur_ligase_C,Mur_ligase_M
TLS2_k127_5384375_3	1123320.KB889675_gene3857	2.621e-158	507.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0008150,GO:0040007	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
TLS2_k127_5384375_2	1463887.KL590001_gene5542	2.141e-167	550.0	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria	201174|Actinobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	GO:0008150,GO:0040007	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_5384375_4	1123320.KB889675_gene3859	1.572e-155	525.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria	201174|Actinobacteria	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2158c	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_5384375_8	471852.Tcur_2932	9.589e-136	467.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4EIDJ@85012|Streptosporangiales	201174|Actinobacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
TLS2_k127_5384375_16	1120950.KB892707_gene4883	6.194e-24	115.0	COG2919@1|root,COG2919@2|Bacteria,2GTFA@201174|Actinobacteria,4DX0A@85009|Propionibacteriales	201174|Actinobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5384375_11	1120950.KB892707_gene4882	1.196e-125	412.0	COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria,4DPXU@85009|Propionibacteriales	201174|Actinobacteria	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
TLS2_k127_5384375_12	1120950.KB892707_gene4880	1.195e-68	235.0	COG2001@1|root,COG2001@2|Bacteria,2IHUB@201174|Actinobacteria,4DQJP@85009|Propionibacteriales	201174|Actinobacteria	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
TLS2_k127_5384375_5	1394178.AWOO02000032_gene4886	1.204e-144	469.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4EHCA@85012|Streptosporangiales	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	yeaC	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_5384375_10	1120950.KB892707_gene4878	1.533e-131	432.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4DNDP@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_5384375_6	1120950.KB892707_gene4877	6.434e-142	494.0	COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria,4DNMN@85009|Propionibacteriales	201174|Actinobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
TLS2_k127_5384375_15	1048339.KB913029_gene4589	1.447e-32	132.0	2E49S@1|root,32RRE@2|Bacteria,2I83P@201174|Actinobacteria,4ETFD@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3040
TLS2_k127_5441183_5	28444.JODQ01000001_gene2340	0.000539	43.0	COG1609@1|root,COG1609@2|Bacteria,2GJV7@201174|Actinobacteria	201174|Actinobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_5441183_3	710111.FraQA3DRAFT_5458	2.408e-91	308.0	COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,4ESDQ@85013|Frankiales	201174|Actinobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS2_k127_5441183_1	1385519.N801_15180	5.034e-212	685.0	COG2232@1|root,COG2232@2|Bacteria,2HPI0@201174|Actinobacteria,4FK2A@85021|Intrasporangiaceae	201174|Actinobacteria	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
TLS2_k127_5441183_2	1385519.N801_15185	5.88e-160	523.0	COG2114@1|root,COG3437@1|root,COG2114@2|Bacteria,COG3437@2|Bacteria,2GNPX@201174|Actinobacteria,4FFVN@85021|Intrasporangiaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	osaB	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_5441183_4	258533.BN977_04095	1.958e-33	142.0	COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,2I5NY@201174|Actinobacteria,236BA@1762|Mycobacteriaceae	201174|Actinobacteria	KT	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	Guanylate_cyc,Response_reg
TLS2_k127_5441183_0	1385519.N801_15195	7.992e-265	843.0	COG0642@1|root,COG2205@2|Bacteria,2I2M2@201174|Actinobacteria,4FFYD@85021|Intrasporangiaceae	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
TLS2_k127_5530937_6	935866.JAER01000013_gene1053	3.774e-43	164.0	COG0791@1|root,COG0791@2|Bacteria,2GKHE@201174|Actinobacteria,4DQS1@85009|Propionibacteriales	201174|Actinobacteria	M	NlpC/P60 family	-	-	-	ko:K21471,ko:K21473	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
TLS2_k127_5530937_4	1463820.JOGW01000017_gene4147	5.202e-85	291.0	COG0221@1|root,COG0221@2|Bacteria,2GM7F@201174|Actinobacteria	201174|Actinobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3628	Pyrophosphatase
TLS2_k127_5530937_5	479435.Kfla_6472	1.38e-82	291.0	COG2027@1|root,COG2027@2|Bacteria,2GJPH@201174|Actinobacteria,4DN2Y@85009|Propionibacteriales	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
TLS2_k127_5530937_1	1120950.KB892801_gene1712	5.656e-134	436.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,4DNQY@85009|Propionibacteriales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
TLS2_k127_5530937_2	1236902.ANAS01000005_gene4623	1.645e-99	334.0	COG0037@1|root,COG0037@2|Bacteria,2GJR4@201174|Actinobacteria,4EHNI@85012|Streptosporangiales	201174|Actinobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	GO:0008150,GO:0040007	2.4.2.8,6.3.4.19	ko:K00760,ko:K04075	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,TilS
TLS2_k127_5530937_3	1120950.KB892801_gene1715	1.984e-85	298.0	COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,4DN1D@85009|Propionibacteriales	201174|Actinobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS2_k127_5530937_0	1120950.KB892801_gene1716	2e-227	713.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4DP9B@85009|Propionibacteriales	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TLS2_k127_5593580_1	1246995.AFR_17410	1.323e-22	100.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,2GKCX@201174|Actinobacteria,4DI6E@85008|Micromonosporales	201174|Actinobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
TLS2_k127_5593580_2	35754.JNYJ01000014_gene4718	3.413e-17	94.0	2BIHD@1|root,32CQ4@2|Bacteria,2HV20@201174|Actinobacteria,4DGII@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS2_k127_5593580_4	1121272.KB903290_gene4691	3.028e-12	79.0	2E0MB@1|root,32W6J@2|Bacteria,2IR53@201174|Actinobacteria,4DJC2@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5593580_0	1394178.AWOO02000020_gene7401	2.064e-95	316.0	COG0491@1|root,COG0491@2|Bacteria,2GJ7I@201174|Actinobacteria,4EH0N@85012|Streptosporangiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_5593580_3	479431.Namu_3067	5.129e-17	89.0	2C2Y4@1|root,333DJ@2|Bacteria,2IQWE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5618370_8	1137268.AZXF01000010_gene2766	3.855e-23	104.0	COG1920@1|root,COG1920@2|Bacteria,2HJNU@201174|Actinobacteria,4EIV2@85012|Streptosporangiales	201174|Actinobacteria	S	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC,NTP_transf_3
TLS2_k127_5618370_4	1385520.N802_18880	1.42e-80	277.0	COG0204@1|root,COG0204@2|Bacteria,2GKVA@201174|Actinobacteria,4FFUB@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acyltransferase	plsC2	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_5618370_0	44060.JODL01000009_gene1828	3.697e-147	474.0	COG0240@1|root,COG0240@2|Bacteria,2GJSD@201174|Actinobacteria	201174|Actinobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
TLS2_k127_5618370_3	196162.Noca_3292	2.171e-117	411.0	COG0626@1|root,COG0626@2|Bacteria,2GMD8@201174|Actinobacteria,4DPBS@85009|Propionibacteriales	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metB	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS2_k127_5618370_1	1123320.KB889676_gene2893	4.654e-140	467.0	COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TLS2_k127_5618370_7	1394178.AWOO02000025_gene4973	1.141e-28	121.0	2CQFE@1|root,32SM3@2|Bacteria,2GRVK@201174|Actinobacteria,4EKEN@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF3515)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3515
TLS2_k127_5618370_5	479435.Kfla_4827	9.459e-35	137.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria,4DRPI@85009|Propionibacteriales	201174|Actinobacteria	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
TLS2_k127_5618370_2	1120950.KB892741_gene2703	4.101e-121	397.0	COG0611@1|root,COG0611@2|Bacteria,2GP6E@201174|Actinobacteria,4DNV9@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0008150,GO:0040007	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2977c	AIRS,AIRS_C
TLS2_k127_5618370_6	1298880.AUEV01000006_gene4324	3.807e-33	128.0	COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
TLS2_k127_5623293_7	1403819.BATR01000069_gene2031	1.854e-38	167.0	COG1470@1|root,COG1749@1|root,COG3291@1|root,COG3506@1|root,COG3533@1|root,COG1470@2|Bacteria,COG1749@2|Bacteria,COG3291@2|Bacteria,COG3506@2|Bacteria,COG3533@2|Bacteria,46SQ1@74201|Verrucomicrobia,2IV3A@203494|Verrucomicrobiae	203494|Verrucomicrobiae	N	Erythromycin esterase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5623293_0	251221.35211117	1.033e-162	550.0	COG2133@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,1G2CB@1117|Cyanobacteria	1117|Cyanobacteria	G	Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4347,GSDH,Laminin_G_3,Lectin_C
TLS2_k127_5623293_5	1122939.ATUD01000007_gene2100	5.832e-103	347.0	COG1253@1|root,COG1253@2|Bacteria,2GJ8X@201174|Actinobacteria,4CR4X@84995|Rubrobacteria	84995|Rubrobacteria	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
TLS2_k127_5623293_3	1306174.JODP01000018_gene4496	9.92e-126	420.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria	201174|Actinobacteria	NU	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_5623293_4	269800.Tfu_0358	2.096e-122	397.0	COG3384@1|root,COG3384@2|Bacteria,2GKTV@201174|Actinobacteria,4EJB1@85012|Streptosporangiales	201174|Actinobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
TLS2_k127_5623293_6	1122182.KB903825_gene445	2.785e-55	198.0	COG1846@1|root,COG1846@2|Bacteria,2GMV1@201174|Actinobacteria,4DEG2@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_5623293_1	105422.BBPM01000001_gene4828	1.055e-145	487.0	COG0339@1|root,COG0339@2|Bacteria,2GM2Z@201174|Actinobacteria,2NF2Z@228398|Streptacidiphilus	201174|Actinobacteria	E	Peptidase family M3	-	-	3.4.24.15	ko:K01392	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
TLS2_k127_5623293_2	1298863.AUEP01000017_gene4151	7.613e-133	441.0	COG2021@1|root,COG3629@1|root,COG2021@2|Bacteria,COG3629@2|Bacteria,2I3CQ@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
TLS2_k127_5623293_8	1193181.BN10_620023	1.603e-24	110.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	iAF987.Gmet_2142	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
TLS2_k127_5634092_5	1146883.BLASA_3390	7.948e-54	192.0	2B9NF@1|root,3230S@2|Bacteria,2IGF5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	-
TLS2_k127_5634092_4	526225.Gobs_4346	5.49e-62	217.0	COG2323@1|root,COG2323@2|Bacteria,2IK7N@201174|Actinobacteria,4ETKC@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
TLS2_k127_5634092_0	1386089.N865_18725	4.004e-183	597.0	COG3239@1|root,COG3239@2|Bacteria,2H2JW@201174|Actinobacteria,4FFD7@85021|Intrasporangiaceae	201174|Actinobacteria	I	fatty acid desaturase	desA3	-	1.14.19.3	ko:K00508	ko00591,ko01100,map00591,map01100	-	R07063	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
TLS2_k127_5634092_2	263358.VAB18032_19765	2.115e-139	451.0	COG1018@1|root,COG1018@2|Bacteria,2GJSW@201174|Actinobacteria,4DB4S@85008|Micromonosporales	201174|Actinobacteria	C	Oxidoreductase FAD-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
TLS2_k127_5634092_1	1089544.KB912942_gene1881	2.152e-168	559.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4DXVG@85010|Pseudonocardiales	201174|Actinobacteria	G	hydrolase, family 65, central catalytic	kojP	-	2.4.1.230	ko:K10231	-	-	-	-	ko00000,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
TLS2_k127_5634092_3	351607.Acel_0140	3.493e-118	392.0	COG0438@1|root,COG0438@2|Bacteria,2I005@201174|Actinobacteria,4ESZ4@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_5634092_8	469371.Tbis_0395	5.223e-24	105.0	COG0239@1|root,COG0239@2|Bacteria,2IKWG@201174|Actinobacteria,4E5I3@85010|Pseudonocardiales	201174|Actinobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB1	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TLS2_k127_5634092_6	1214101.BN159_8050	1.415e-36	150.0	COG1993@1|root,COG1993@2|Bacteria,2IM7J@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
TLS2_k127_5634092_7	479433.Caci_3965	1.424e-27	119.0	COG0239@1|root,COG0239@2|Bacteria,2IKM1@201174|Actinobacteria	201174|Actinobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB1	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TLS2_k127_5661078_9	1449355.JQNR01000005_gene4062	1.526e-35	141.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS2_k127_5661078_3	1380347.JNII01000006_gene1657	6.352e-151	499.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4ETXS@85013|Frankiales	201174|Actinobacteria	EP	Oligopeptide/dipeptide transporter, C-terminal region	dppD	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS2_k127_5661078_6	1449068.JMLQ01000008_gene4118	1.377e-112	372.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4FUFB@85025|Nocardiaceae	201174|Actinobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
TLS2_k127_5661078_4	136273.GY22_01115	1.081e-148	477.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria,1W8S7@1268|Micrococcaceae	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
TLS2_k127_5661078_1	1146883.BLASA_0934	1.827e-228	721.0	COG4166@1|root,COG4166@2|Bacteria,2GIUH@201174|Actinobacteria,4EV05@85013|Frankiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	oppA	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
TLS2_k127_5661078_0	1394178.AWOO02000101_gene8270	3.764e-317	982.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4EFWD@85012|Streptosporangiales	201174|Actinobacteria	T	Elongation factor G C-terminus	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_5661078_11	909613.UO65_2804	4.224e-11	75.0	COG2909@1|root,COG2909@2|Bacteria,2IHD0@201174|Actinobacteria,4E2YF@85010|Pseudonocardiales	201174|Actinobacteria	K	trisaccharide binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5661078_7	446466.Cfla_1013	4.536e-44	177.0	COG0510@1|root,COG0510@2|Bacteria,2I6BT@201174|Actinobacteria	201174|Actinobacteria	M	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_5661078_8	1896.JOAU01000003_gene1319	8.339e-44	176.0	COG1051@1|root,COG1051@2|Bacteria,2IQEA@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the NUDIX hydrolase family	mutT2	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS2_k127_5661078_5	345341.KUTG_07266	1.258e-120	391.0	2CEY7@1|root,2Z8CG@2|Bacteria,2GKI0@201174|Actinobacteria,4DXN2@85010|Pseudonocardiales	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5661078_2	1120950.KB892823_gene529	3.843e-211	666.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4DPTE@85009|Propionibacteriales	201174|Actinobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_5707989_12	1123024.AUII01000010_gene717	1.314e-08	63.0	COG2259@1|root,COG2259@2|Bacteria,2IQEY@201174|Actinobacteria,4E4QN@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Methylamine utilisation protein MauE	-	-	-	-	-	-	-	-	-	-	-	-	DoxX,MauE
TLS2_k127_5707989_7	935839.JAGJ01000007_gene3245	1.123e-75	274.0	COG4221@1|root,COG4221@2|Bacteria,2I2JD@201174|Actinobacteria,4F4EQ@85017|Promicromonosporaceae	201174|Actinobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_5707989_0	1122933.JNIY01000003_gene1143	5.477e-312	987.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2GMFD@201174|Actinobacteria,4F0PI@85016|Cellulomonadaceae	201174|Actinobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
TLS2_k127_5707989_3	1120950.KB892768_gene5215	7.501e-183	578.0	COG0016@1|root,COG0016@2|Bacteria,2GJGG@201174|Actinobacteria,4DPA8@85009|Propionibacteriales	201174|Actinobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
TLS2_k127_5707989_6	1464048.JNZS01000019_gene2340	6.635e-81	279.0	COG0566@1|root,COG0566@2|Bacteria,2GJI6@201174|Actinobacteria,4DAJB@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	tsnR	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS2_k127_5707989_8	1003195.SCAT_5206	1.268e-59	211.0	COG0292@1|root,COG0292@2|Bacteria,2IHTN@201174|Actinobacteria	201174|Actinobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
TLS2_k127_5707989_11	743718.Isova_1326	1.996e-23	106.0	COG0291@1|root,COG0291@2|Bacteria,2GQZW@201174|Actinobacteria,4F507@85017|Promicromonosporaceae	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
TLS2_k127_5707989_5	479435.Kfla_5455	2.371e-89	303.0	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,4DNG8@85009|Propionibacteriales	201174|Actinobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
TLS2_k127_5707989_9	1122138.AQUZ01000041_gene7273	3.851e-44	162.0	2AI3Y@1|root,318HW@2|Bacteria,2IHSQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5707989_10	2045.KR76_12415	2.593e-29	125.0	COG1404@1|root,COG1404@2|Bacteria,2GMN0@201174|Actinobacteria,4DRFX@85009|Propionibacteriales	201174|Actinobacteria	O	SseB protein N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SseB
TLS2_k127_5707989_2	367299.JOEE01000007_gene56	1.174e-194	618.0	2DBC4@1|root,2Z8BS@2|Bacteria,2GYBF@201174|Actinobacteria,4FFCU@85021|Intrasporangiaceae	201174|Actinobacteria	S	Responsible for the hydrolysis of barbituric acid (2,4,6-trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid	bar	-	3.5.2.1,3.5.2.15	ko:K03383,ko:K19794	ko00240,ko00791,ko01100,ko01120,map00240,map00791,map01100,map01120	-	R02139,R05561,R10777	RC00632,RC00680,RC01423,RC03058	ko00000,ko00001,ko01000	-	-	-	Amido_AtzD_TrzD
TLS2_k127_5707989_4	196162.Noca_1504	7.297e-128	415.0	COG0549@1|root,COG0549@2|Bacteria,2HWQ6@201174|Actinobacteria,4DPEI@85009|Propionibacteriales	201174|Actinobacteria	E	Belongs to the carbamate kinase family	arcC	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS2_k127_5707989_1	710696.Intca_3032	1.198e-238	745.0	COG0777@1|root,COG0825@1|root,COG0777@2|Bacteria,COG0825@2|Bacteria,2GNP7@201174|Actinobacteria,4FE8J@85021|Intrasporangiaceae	201174|Actinobacteria	I	acetyl-CoA carboxylase	accDA	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_5709330_0	1236902.ANAS01000001_gene1892	5.198e-108	362.0	COG0475@1|root,COG0475@2|Bacteria,2GIRC@201174|Actinobacteria,4EN0R@85012|Streptosporangiales	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS2_k127_5709330_1	397278.JOJN01000003_gene1887	3.939e-58	226.0	COG3288@1|root,COG3288@2|Bacteria,2I2FZ@201174|Actinobacteria,4DNG1@85009|Propionibacteriales	201174|Actinobacteria	C	NAD(P) transhydrogenase, alpha subunit	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
TLS2_k127_5723739_3	1122611.KB903970_gene2620	3.024e-30	139.0	COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4EI8P@85012|Streptosporangiales	201174|Actinobacteria	KT	Transcriptional regulatory protein, C terminal	glnR	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS2_k127_5723739_0	28444.JODQ01000015_gene1799	1.786e-77	267.0	COG1073@1|root,COG1073@2|Bacteria,2GNUS@201174|Actinobacteria,4EI2H@85012|Streptosporangiales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
TLS2_k127_5723739_4	1120950.KB892777_gene735	2.706e-23	109.0	COG1977@1|root,COG1977@2|Bacteria,2I1HE@201174|Actinobacteria,4DSU2@85009|Propionibacteriales	201174|Actinobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
TLS2_k127_5723739_6	935839.JAGJ01000030_gene3029	0.0001627	53.0	2DJPX@1|root,32UDI@2|Bacteria,2IFS0@201174|Actinobacteria,4F4HA@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5723739_1	452652.KSE_16960	1.429e-44	166.0	COG0526@1|root,COG0526@2|Bacteria,2IKMI@201174|Actinobacteria,2M3AR@2063|Kitasatospora	201174|Actinobacteria	CO	Thioredoxin	thiX	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
TLS2_k127_5723739_2	561175.KB894093_gene3341	1.005e-36	147.0	2AN8T@1|root,327DN@2|Bacteria,2I81P@201174|Actinobacteria,4EPIS@85012|Streptosporangiales	201174|Actinobacteria	S	Domain of unknown function (DUF4395)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4395
TLS2_k127_5723739_5	1123320.KB889669_gene3198	4.549e-21	101.0	COG2897@1|root,COG2897@2|Bacteria,2GIYU@201174|Actinobacteria	201174|Actinobacteria	P	sulfurtransferase	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS2_k127_572961_7	1122622.ATWJ01000009_gene3141	3.408e-42	161.0	COG1595@1|root,COG1595@2|Bacteria,2GKFQ@201174|Actinobacteria,4FGF5@85021|Intrasporangiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_572961_6	1122609.AUGT01000005_gene1643	1.225e-60	212.0	COG0105@1|root,COG0105@2|Bacteria,2IFBU@201174|Actinobacteria,4DQR5@85009|Propionibacteriales	201174|Actinobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	iNJ661.Rv2445c	NDK
TLS2_k127_572961_8	1229203.KI301992_gene474	4.347e-23	110.0	2E69F@1|root,330XE@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF4233)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4233
TLS2_k127_572961_2	1048339.KB913029_gene4866	3.921e-169	555.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4ERQF@85013|Frankiales	201174|Actinobacteria	H	Mur ligase, middle domain protein	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2447c	Mur_ligase_C,Mur_ligase_M
TLS2_k127_572961_0	1048339.KB913029_gene4867	0.0	1433.0	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4ERSS@85013|Frankiales	201174|Actinobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TLS2_k127_572961_3	1122611.KB903939_gene515	1.057e-159	515.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria,4EG9K@85012|Streptosporangiales	201174|Actinobacteria	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_572961_5	479432.Sros_5704	2.226e-63	237.0	COG3375@1|root,COG3375@2|Bacteria,2I8MV@201174|Actinobacteria,4EIJG@85012|Streptosporangiales	201174|Actinobacteria	M	Mandelate Racemase Muconate Lactonizing	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_6
TLS2_k127_572961_4	1246995.AFR_18850	8.665e-134	437.0	COG0624@1|root,COG0624@2|Bacteria,2GMH2@201174|Actinobacteria,4DAAB@85008|Micromonosporales	201174|Actinobacteria	E	Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_572961_1	330084.JNYZ01000011_gene7249	2.083e-230	718.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,4DYXZ@85010|Pseudonocardiales	201174|Actinobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
TLS2_k127_5743674_1	65497.JODV01000004_gene1483	2.65e-88	297.0	COG4912@1|root,COG4912@2|Bacteria,2ID3C@201174|Actinobacteria,4E7JU@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
TLS2_k127_5743674_2	749927.AMED_1048	2.583e-80	275.0	COG4122@1|root,COG4122@2|Bacteria,2IA2G@201174|Actinobacteria,4E0GD@85010|Pseudonocardiales	201174|Actinobacteria	S	Macrocin-O-methyltransferase (TylF)	-	-	-	ko:K19856,ko:K21325	ko00523,ko01130,map00523,map01130	M00799	R11041,R11469	RC00003,RC00466	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_24,TylF
TLS2_k127_5743674_0	269800.Tfu_1930	3.294e-218	680.0	COG2141@1|root,COG2141@2|Bacteria,2GKCU@201174|Actinobacteria,4EFXQ@85012|Streptosporangiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_5743674_3	1237500.ANBA01000021_gene5280	9.871e-71	245.0	COG0431@1|root,COG0431@2|Bacteria,2IHWU@201174|Actinobacteria,4EIMU@85012|Streptosporangiales	201174|Actinobacteria	S	NADPH-dependent FMN reductase	ssuE	-	1.5.1.38	ko:K00299	ko00740,ko00920,ko01100,map00740,map00920,map01100	-	R05706,R07210,R10206	RC00126,RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	FMN_red
TLS2_k127_5769528_2	1120950.KB892709_gene4058	4.235e-29	132.0	COG2852@1|root,COG2852@2|Bacteria,2GNZQ@201174|Actinobacteria,4DRIU@85009|Propionibacteriales	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
TLS2_k127_5769528_0	1120950.KB892779_gene974	1.153e-167	548.0	COG1169@1|root,COG1169@2|Bacteria,2GKE8@201174|Actinobacteria,4DPGF@85009|Propionibacteriales	201174|Actinobacteria	HQ	Isochorismate synthase	menF	-	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
TLS2_k127_5769528_1	1123024.AUII01000003_gene3440	3.333e-72	248.0	COG1165@1|root,COG1165@2|Bacteria,2GMEB@201174|Actinobacteria,4DYET@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
TLS2_k127_5790740_0	1048339.KB913029_gene2313	1.599e-151	500.0	COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4EUUS@85013|Frankiales	201174|Actinobacteria	V	MacB-like periplasmic core domain	yknZ	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_5790740_1	28444.JODQ01000014_gene6730	6.114e-95	331.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4EMMN@85012|Streptosporangiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_5790740_3	479433.Caci_8343	1.49e-86	304.0	COG0845@1|root,COG0845@2|Bacteria,2I8EY@201174|Actinobacteria	201174|Actinobacteria	M	Efflux transporter, RND family, MFP subunit	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TLS2_k127_5790740_2	110319.CF8_3257	2.712e-91	307.0	COG0168@1|root,COG0168@2|Bacteria,2GKKS@201174|Actinobacteria,4DNQE@85009|Propionibacteriales	201174|Actinobacteria	P	Cation transport protein	-	-	-	-	-	-	-	-	-	-	-	-	TrkH
TLS2_k127_5814270_1	675635.Psed_5720	1.179e-18	89.0	COG1983@1|root,COG1983@2|Bacteria,2GRA8@201174|Actinobacteria,4E6GD@85010|Pseudonocardiales	201174|Actinobacteria	KT	PspC domain	-	-	-	-	-	-	-	-	-	-	-	-	PspC
TLS2_k127_5814270_0	1048339.KB913029_gene2809	6.368e-267	829.0	COG0519@1|root,COG0519@2|Bacteria,2GM09@201174|Actinobacteria,4ERBR@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
TLS2_k127_5838755_0	1068980.ARVW01000001_gene4474	8.394e-91	306.0	COG2267@1|root,COG2267@2|Bacteria,2I5HD@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_5838755_1	1068980.ARVW01000001_gene136	1.628e-15	87.0	294PK@1|root,2ZS2X@2|Bacteria,2H0KK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5847254_1	1146883.BLASA_1739	1.631e-109	378.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria	2|Bacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilizers,PPDK_N
TLS2_k127_5847254_2	1386089.N865_16490	7.735e-101	338.0	COG0508@1|root,COG0508@2|Bacteria,2I8Q8@201174|Actinobacteria,4FEUV@85021|Intrasporangiaceae	201174|Actinobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh
TLS2_k127_5847254_0	290399.Arth_3983	1.074e-229	720.0	COG2272@1|root,COG2272@2|Bacteria,2GJCN@201174|Actinobacteria,1W8S6@1268|Micrococcaceae	201174|Actinobacteria	I	PFAM Carboxylesterase	pnbA	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
TLS2_k127_5847254_3	196162.Noca_1153	9.839e-06	48.0	COG2337@1|root,COG2337@2|Bacteria,2IR5D@201174|Actinobacteria,4DVPS@85009|Propionibacteriales	201174|Actinobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
TLS2_k127_584800_9	1120950.KB892708_gene4491	6.698e-43	161.0	2CNY9@1|root,32SI2@2|Bacteria,2IMK6@201174|Actinobacteria,4DQUX@85009|Propionibacteriales	201174|Actinobacteria	K	Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters	rbpA	GO:0001000,GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0043167,GO:0043169,GO:0043175,GO:0045893,GO:0045935,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	RbpA
TLS2_k127_584800_1	1120950.KB892757_gene6517	2.522e-182	582.0	COG2270@1|root,COG2270@2|Bacteria,2GJCW@201174|Actinobacteria,4DNKE@85009|Propionibacteriales	201174|Actinobacteria	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
TLS2_k127_584800_2	1894.JOER01000002_gene3502	5e-92	310.0	COG0584@1|root,COG0584@2|Bacteria,2GJ5W@201174|Actinobacteria	201174|Actinobacteria	C	glycerophosphoryl diester phosphodiesterase	glpQ2	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS2_k127_584800_11	1278078.G419_18324	2.019e-31	136.0	2E3HJ@1|root,32YG5@2|Bacteria,2GQV8@201174|Actinobacteria,4G1VX@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_584800_8	1120950.KB892771_gene1323	9.12e-56	201.0	COG2522@1|root,COG2522@2|Bacteria,2IP64@201174|Actinobacteria,4DR94@85009|Propionibacteriales	201174|Actinobacteria	O	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	SatD
TLS2_k127_584800_4	570268.ANBB01000007_gene5469	8.879e-84	301.0	COG1834@1|root,COG1834@2|Bacteria,2GNTN@201174|Actinobacteria,4EK6I@85012|Streptosporangiales	201174|Actinobacteria	E	Amidinotransferase	ddaH	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
TLS2_k127_584800_6	1123024.AUII01000048_gene808	1.504e-80	270.0	COG2207@1|root,COG2207@2|Bacteria,2IFDE@201174|Actinobacteria,4E2S3@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Bacterial regulatory helix-turn-helix proteins, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS2_k127_584800_7	1123024.AUII01000048_gene807	1.395e-78	271.0	COG0346@1|root,COG0346@2|Bacteria,2IHYP@201174|Actinobacteria,4E3KN@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_584800_5	1120950.KB892757_gene6562	3.144e-81	272.0	COG3576@1|root,COG3576@2|Bacteria,2IG3P@201174|Actinobacteria,4DSD0@85009|Propionibacteriales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_584800_0	1429046.RR21198_2410	0.0	1410.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4FU6V@85025|Nocardiaceae	201174|Actinobacteria	L	ABC transporter	uvrA2	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_584800_3	1121924.ATWH01000008_gene684	6.177e-85	299.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4FMY3@85023|Microbacteriaceae	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_584800_10	1463856.JOHY01000041_gene7204	2.543e-41	162.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS2_k127_5848724_1	1123320.KB889640_gene4459	1.593e-51	205.0	COG3427@1|root,COG3427@2|Bacteria,2IEYK@201174|Actinobacteria	201174|Actinobacteria	S	carbon monoxide dehydrogenase subunit G	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
TLS2_k127_5848724_0	1123320.KB889640_gene4458	0.0	1093.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria	201174|Actinobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_5858859_5	1120950.KB892742_gene3010	1.506e-81	275.0	COG3288@1|root,COG3288@2|Bacteria,2I2FZ@201174|Actinobacteria,4DNG1@85009|Propionibacteriales	201174|Actinobacteria	C	NAD(P) transhydrogenase, alpha subunit	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
TLS2_k127_5858859_9	1101188.KI912156_gene4103	1.573e-35	138.0	COG3288@1|root,COG3288@2|Bacteria,2IKR9@201174|Actinobacteria	201174|Actinobacteria	C	NADP transhydrogenase	pntAB	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
TLS2_k127_5858859_2	1298863.AUEP01000006_gene3284	1.191e-170	552.0	COG1282@1|root,COG1282@2|Bacteria,2GNKB@201174|Actinobacteria,4DNP9@85009|Propionibacteriales	201174|Actinobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
TLS2_k127_5858859_4	935866.JAER01000004_gene3856	3.86e-108	355.0	COG0035@1|root,COG0035@2|Bacteria,2GPJE@201174|Actinobacteria,4DPRI@85009|Propionibacteriales	201174|Actinobacteria	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
TLS2_k127_5858859_7	479435.Kfla_0327	5.177e-53	194.0	2BM8T@1|root,32FSI@2|Bacteria,2IG06@201174|Actinobacteria,4DR8K@85009|Propionibacteriales	201174|Actinobacteria	S	tRNA adenosine	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5858859_10	1214242.B446_18520	3.031e-35	142.0	2E70D@1|root,331J9@2|Bacteria,2GYEC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5858859_6	351607.Acel_2018	1.195e-66	229.0	COG0590@1|root,COG0590@2|Bacteria,2IM3Z@201174|Actinobacteria,4ESSJ@85013|Frankiales	201174|Actinobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.1,3.5.4.33	ko:K01485,ko:K11991	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922,R10223	RC00074,RC00477,RC00514,RC00809	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
TLS2_k127_5858859_1	1229780.BN381_290161	1.927e-189	601.0	COG3177@1|root,COG3177@2|Bacteria,2GN3K@201174|Actinobacteria,3UXE6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
TLS2_k127_5858859_0	526225.Gobs_2947	6.981e-211	669.0	COG3263@1|root,COG3263@2|Bacteria,2GJ9B@201174|Actinobacteria,4EUKM@85013|Frankiales	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger,TrkA_C
TLS2_k127_5858859_11	313589.JNB_10394	3.092e-17	89.0	2ED0J@1|root,336XJ@2|Bacteria,2I7ZH@201174|Actinobacteria,4FGMA@85021|Intrasporangiaceae	201174|Actinobacteria	S	LytR cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C
TLS2_k127_5858859_8	446471.Xcel_0235	2.498e-43	162.0	COG5450@1|root,32SQA@2|Bacteria,2IKJX@201174|Actinobacteria,4F4M0@85017|Promicromonosporaceae	201174|Actinobacteria	K	Transcription regulator of the Arc MetJ class	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5858859_3	1385518.N798_02040	2.579e-127	416.0	COG0433@1|root,COG0433@2|Bacteria,2GM12@201174|Actinobacteria,4FERS@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
TLS2_k127_5874230_0	1211815.CBYP010000036_gene2225	1.669e-226	709.0	COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria,4ESTY@85013|Frankiales	201174|Actinobacteria	E	PFAM extracellular solute-binding protein family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_5874230_2	526225.Gobs_0311	6.788e-144	464.0	COG0601@1|root,COG0601@2|Bacteria,2GK0Z@201174|Actinobacteria,4ETSF@85013|Frankiales	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_5874230_4	1380347.JNII01000012_gene2650	8.478e-118	401.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4ESQD@85013|Frankiales	201174|Actinobacteria	P	ABC-type dipeptide oligopeptide nickel transport system, permease component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_5874230_3	526225.Gobs_0313	2.052e-134	441.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4EUEK@85013|Frankiales	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_5874230_1	266940.Krad_3859	5.821e-159	506.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_5945501_1	1043493.BBLU01000020_gene1066	3.098e-110	379.0	COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,2ID98@201174|Actinobacteria	201174|Actinobacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_12
TLS2_k127_5945501_0	469383.Cwoe_0405	2.425e-174	561.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4CSD5@84995|Rubrobacteria	84995|Rubrobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS2_k127_5945501_3	1234364.AMSF01000016_gene1512	0.0001273	45.0	2DNU1@1|root,32Z4S@2|Bacteria,1N8FB@1224|Proteobacteria,1THVX@1236|Gammaproteobacteria,1XAUP@135614|Xanthomonadales	135614|Xanthomonadales	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
TLS2_k127_5945501_2	1121946.AUAX01000020_gene3209	5.724e-05	46.0	COG1917@1|root,COG1917@2|Bacteria,2IIQD@201174|Actinobacteria,4DF71@85008|Micromonosporales	201174|Actinobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_5974589_1	1211815.CBYP010000042_gene2348	2.599e-222	702.0	COG0018@1|root,COG0018@2|Bacteria,2GKQ3@201174|Actinobacteria,4ERR2@85013|Frankiales	201174|Actinobacteria	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
TLS2_k127_5974589_4	2074.JNYD01000007_gene2072	1.974e-72	251.0	2A84P@1|root,30X5E@2|Bacteria,2IN6P@201174|Actinobacteria,4EBJJ@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5974589_3	247156.NFA_24610	3.619e-73	255.0	COG0637@1|root,COG0637@2|Bacteria,2I362@201174|Actinobacteria,4FYI5@85025|Nocardiaceae	201174|Actinobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS2_k127_5974589_8	444157.Tneu_0173	1.92e-18	90.0	COG0517@1|root,arCOG00606@2157|Archaea,2XR4V@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_5974589_5	1123024.AUII01000009_gene2037	1.575e-67	235.0	COG0500@1|root,COG2226@2|Bacteria,2I36Q@201174|Actinobacteria,4E5FR@85010|Pseudonocardiales	201174|Actinobacteria	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_5974589_0	263358.VAB18032_11710	4.548e-239	748.0	COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,4DB0E@85008|Micromonosporales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS2_k127_5974589_7	251221.35212827	5.508e-19	89.0	2DMEM@1|root,32R0F@2|Bacteria,1GHES@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5974589_10	1210046.B277_00460	1.052e-06	60.0	2DMEM@1|root,32R0F@2|Bacteria,2I6QB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5974589_12	479432.Sros_7444	0.00014	47.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4EFHS@85012|Streptosporangiales	201174|Actinobacteria	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_5974589_6	644283.Micau_1683	1.766e-48	184.0	COG1309@1|root,COG1309@2|Bacteria,2GP3D@201174|Actinobacteria,4DD5T@85008|Micromonosporales	201174|Actinobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
TLS2_k127_5974589_2	1298863.AUEP01000008_gene1264	4.528e-124	410.0	COG3191@1|root,COG3191@2|Bacteria,2H89D@201174|Actinobacteria,4DRX9@85009|Propionibacteriales	201174|Actinobacteria	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
TLS2_k127_5974589_11	28444.JODQ01000002_gene4076	3.296e-06	50.0	COG0123@1|root,COG0123@2|Bacteria,2I8UK@201174|Actinobacteria	201174|Actinobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TLS2_k127_5983726_6	110319.CF8_1918	1.989e-14	83.0	COG3764@1|root,COG3764@2|Bacteria,2IRXZ@201174|Actinobacteria,4DRSR@85009|Propionibacteriales	201174|Actinobacteria	M	PFAM peptidase C60, sortase A and B	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
TLS2_k127_5983726_2	1120950.KB892743_gene3152	1.415e-154	511.0	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,4DNY6@85009|Propionibacteriales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_5983726_0	1120950.KB892743_gene3151	1.296e-173	561.0	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,4DP0A@85009|Propionibacteriales	201174|Actinobacteria	M	Penicillin binding protein transpeptidase domain	pbpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
TLS2_k127_5983726_1	397278.JOJN01000003_gene1721	5.144e-164	535.0	COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,4DPN4@85009|Propionibacteriales	201174|Actinobacteria	D	Belongs to the SEDS family	rodA	GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
TLS2_k127_5983726_3	479435.Kfla_0063	5.487e-101	351.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4DNAN@85009|Propionibacteriales	201174|Actinobacteria	T	Serine/threonine phosphatases, family 2C, catalytic domain	pstP	GO:0000287,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043392,GO:0043412,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0045936,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
TLS2_k127_5983726_5	585531.HMPREF0063_10449	4.17e-42	168.0	COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,4DQIX@85009|Propionibacteriales	201174|Actinobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
TLS2_k127_5983726_4	1033730.CAHG01000007_gene2571	7.351e-74	258.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4DQ6H@85009|Propionibacteriales	201174|Actinobacteria	T	Protein of unknown function (DUF2662)	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
TLS2_k127_5994022_5	710696.Intca_0078	1.074e-19	96.0	COG1266@1|root,COG1266@2|Bacteria,2GKRA@201174|Actinobacteria,4FFZ8@85021|Intrasporangiaceae	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_5994022_1	1463864.JOGO01000086_gene2342	2.433e-113	385.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	pkaH	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_5994022_6	1380356.JNIK01000011_gene1769	4.905e-09	67.0	28ZPD@1|root,2ZMEI@2|Bacteria,2GZTN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5994022_2	44454.NF84_18675	1.135e-78	280.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria,232G7@1762|Mycobacteriaceae	201174|Actinobacteria	G	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_5994022_7	446462.Amir_1017	0.0002094	51.0	COG5592@1|root,COG5592@2|Bacteria,2IJ0S@201174|Actinobacteria,4E312@85010|Pseudonocardiales	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS2_k127_5994022_3	222534.KB893670_gene3630	1.264e-72	256.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4ES7X@85013|Frankiales	201174|Actinobacteria	K	RNA polymerase	sigF	GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_5994022_4	1120797.KB908259_gene893	1.158e-50	190.0	COG2203@1|root,COG2203@2|Bacteria,2I2QK@201174|Actinobacteria,23EYK@1762|Mycobacteriaceae	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS2_k127_5994022_0	1179773.BN6_37970	1.255e-190	614.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria,4E059@85010|Pseudonocardiales	201174|Actinobacteria	Q	Phytoene dehydrogenase-like oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS2_k127_6033722_5	479435.Kfla_6822	1.492e-44	164.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,4DNI0@85009|Propionibacteriales	201174|Actinobacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
TLS2_k127_6033722_2	35754.JNYJ01000015_gene8556	3.193e-61	226.0	2DBMF@1|root,2Z9YG@2|Bacteria,2I871@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6033722_1	1386089.N865_19155	2.169e-70	254.0	29YCS@1|root,30K75@2|Bacteria,2IJFN@201174|Actinobacteria,4FIXN@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6033722_6	215803.DB30_6291	3.659e-42	165.0	COG0454@1|root,COG0456@2|Bacteria,1R96X@1224|Proteobacteria,439EJ@68525|delta/epsilon subdivisions,2X4PQ@28221|Deltaproteobacteria,2YZD4@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
TLS2_k127_6033722_0	1150864.MILUP08_42472	2.14e-147	472.0	COG0208@1|root,COG0208@2|Bacteria,2GKGZ@201174|Actinobacteria,4DAY7@85008|Micromonosporales	201174|Actinobacteria	F	Fatty acid desaturase	desA	-	1.14.19.11,1.14.19.2,1.14.19.26	ko:K03921	ko00061,ko01040,ko01212,map00061,map01040,map01212	-	R03370,R08161,R11108,R11109	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase_2
TLS2_k127_6033722_3	161528.ED21_29211	1.498e-57	211.0	COG0655@1|root,COG0655@2|Bacteria,1N5Q7@1224|Proteobacteria,2U5RW@28211|Alphaproteobacteria,2K2NJ@204457|Sphingomonadales	204457|Sphingomonadales	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS2_k127_6033722_4	1380390.JIAT01000009_gene613	1.817e-49	181.0	COG0655@1|root,COG0655@2|Bacteria,2GKTM@201174|Actinobacteria,4CSK9@84995|Rubrobacteria	84995|Rubrobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS2_k127_6033722_7	1193181.BN10_50005	2.562e-22	97.0	COG1960@1|root,COG1960@2|Bacteria,2GJIB@201174|Actinobacteria,4FEU0@85021|Intrasporangiaceae	201174|Actinobacteria	I	Butyryl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
TLS2_k127_6046560_12	882083.SacmaDRAFT_0191	7.443e-34	141.0	COG1525@1|root,COG1525@2|Bacteria,2GRK1@201174|Actinobacteria	201174|Actinobacteria	L	nuclease	-	-	3.1.31.1	ko:K01174,ko:K07038	-	-	-	-	ko00000,ko01000	-	-	-	SNase
TLS2_k127_6046560_13	1541065.JRFE01000054_gene6425	1.332e-19	93.0	COG1525@1|root,COG1525@2|Bacteria,1G6B2@1117|Cyanobacteria,3VMVC@52604|Pleurocapsales	1117|Cyanobacteria	L	Staphylococcal nuclease homologues	-	-	-	-	-	-	-	-	-	-	-	-	Excalibur,SNase
TLS2_k127_6046560_7	710696.Intca_0415	2.595e-107	372.0	COG0395@1|root,COG0395@2|Bacteria,2GJNN@201174|Actinobacteria,4FFAG@85021|Intrasporangiaceae	201174|Actinobacteria	P	ABC transporter permease	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
TLS2_k127_6046560_5	1122611.KB903944_gene1219	7.913e-125	413.0	COG1175@1|root,COG1175@2|Bacteria,2GJZD@201174|Actinobacteria,4EM98@85012|Streptosporangiales	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
TLS2_k127_6046560_3	1122611.KB903944_gene1220	2.946e-163	526.0	COG1653@1|root,COG1653@2|Bacteria,2GP9H@201174|Actinobacteria,4EK1W@85012|Streptosporangiales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_6046560_4	103733.JNYO01000034_gene2920	1.632e-127	419.0	COG0524@1|root,COG0524@2|Bacteria,2GKQP@201174|Actinobacteria,4DY46@85010|Pseudonocardiales	201174|Actinobacteria	G	pfkB family carbohydrate kinase	scrK	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS2_k127_6046560_9	227882.SAV_1755	2.71e-86	293.0	COG1349@1|root,COG1349@2|Bacteria,2GMAJ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K02444	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
TLS2_k127_6046560_2	1463920.JOGB01000103_gene4234	2.622e-163	537.0	COG1486@1|root,COG1486@2|Bacteria,2GK80@201174|Actinobacteria	201174|Actinobacteria	G	family 4	bglA	-	3.2.1.86	ko:K01222	ko00010,ko00500,map00010,map00500	-	R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
TLS2_k127_6046560_11	1380390.JIAT01000013_gene137	5.795e-69	245.0	COG1349@1|root,COG1349@2|Bacteria,2GJK9@201174|Actinobacteria,4CQZM@84995|Rubrobacteria	84995|Rubrobacteria	GK	DeoR C terminal sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
TLS2_k127_6046560_8	713587.THITH_01090	3.071e-97	335.0	COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria,1RYZ6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Major pilin protein	fimA	-	-	-	-	-	-	-	-	-	-	-	DUF1028
TLS2_k127_6046560_6	285535.JOEY01000046_gene2132	6.009e-117	388.0	COG4924@1|root,COG4924@2|Bacteria,2IB33@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2220,DUF3322
TLS2_k127_6046560_0	1122138.AQUZ01000017_gene6603	0.0	1189.0	COG4913@1|root,COG4913@2|Bacteria,2GMIP@201174|Actinobacteria,4DRB4@85009|Propionibacteriales	201174|Actinobacteria	S	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
TLS2_k127_6046560_10	345341.KUTG_02461	1.455e-80	286.0	2CB46@1|root,31GHU@2|Bacteria,2ID3Z@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4194
TLS2_k127_6046560_1	1122138.AQUZ01000017_gene6601	5.982e-194	616.0	COG4942@1|root,COG4942@2|Bacteria,2GW48@201174|Actinobacteria,4DTK9@85009|Propionibacteriales	201174|Actinobacteria	D	Protein of unknown function (DUF3375)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3375
TLS2_k127_6046560_15	1123251.ATWM01000007_gene2265	1.799e-06	55.0	COG1848@1|root,COG1848@2|Bacteria,2GPX7@201174|Actinobacteria,4FI13@85021|Intrasporangiaceae	201174|Actinobacteria	S	PIN domain	-	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_6046560_14	479431.Namu_3998	6.403e-13	72.0	COG1309@1|root,COG1309@2|Bacteria,2I9NV@201174|Actinobacteria,4EW00@85013|Frankiales	201174|Actinobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
TLS2_k127_6057066_19	1096756.ATKN01000001_gene2049	2.417e-44	168.0	COG0491@1|root,COG0491@2|Bacteria,2GMHY@201174|Actinobacteria	201174|Actinobacteria	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_6057066_6	1463917.JODC01000033_gene8468	2.064e-115	383.0	COG0265@1|root,COG0265@2|Bacteria,2GNZT@201174|Actinobacteria	201174|Actinobacteria	O	Peptidase s1 and s6 chymotrypsin hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_6057066_4	1122611.KB904029_gene5240	1.431e-132	429.0	COG1230@1|root,COG1230@2|Bacteria,2GMRZ@201174|Actinobacteria,4EHYI@85012|Streptosporangiales	201174|Actinobacteria	P	Cation efflux family	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
TLS2_k127_6057066_25	1894.JOER01000072_gene7837	3.605e-09	69.0	COG3209@1|root,COG3209@2|Bacteria,2IAE9@201174|Actinobacteria	201174|Actinobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6057066_5	1089545.KB913037_gene6015	3.428e-118	392.0	COG0809@1|root,COG0809@2|Bacteria,2GN51@201174|Actinobacteria,4E2HP@85010|Pseudonocardiales	201174|Actinobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
TLS2_k127_6057066_14	1449976.KALB_2930	6.685e-76	264.0	COG1028@1|root,COG1028@2|Bacteria,2HGA2@201174|Actinobacteria,4E2M4@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_6057066_17	675635.Psed_1176	1.423e-64	224.0	COG0789@1|root,COG0789@2|Bacteria,2GKTU@201174|Actinobacteria,4E3MA@85010|Pseudonocardiales	201174|Actinobacteria	K	TIGRFAM redox-sensitive transcriptional activator SoxR	soxR	-	-	ko:K13639	-	-	-	-	ko00000,ko03000	-	-	-	MerR,MerR-DNA-bind,MerR_1
TLS2_k127_6057066_10	479431.Namu_5044	4.406e-101	346.0	COG0477@1|root,COG2814@2|Bacteria,2HF67@201174|Actinobacteria,4EWG3@85013|Frankiales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_6057066_13	1211815.CBYP010000075_gene2952	3.021e-77	268.0	COG1295@1|root,COG1295@2|Bacteria	2|Bacteria	S	lipopolysaccharide transmembrane transporter activity	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_6057066_11	1211815.CBYP010000029_gene1234	1.535e-97	330.0	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,4ESP8@85013|Frankiales	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K20469	-	-	-	-	ko00000,ko02000	2.A.86.1.7	-	-	AI-2E_transport
TLS2_k127_6057066_0	1211815.CBYP010000002_gene1997	2.827e-258	807.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria,4EUUN@85013|Frankiales	201174|Actinobacteria	G	Evidence 2b Function of strongly homologous gene	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
TLS2_k127_6057066_18	494419.ALPM01000029_gene3128	3.414e-47	179.0	COG3554@1|root,COG3554@2|Bacteria,2GUNF@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	ko:K09957	-	-	-	-	ko00000	-	-	-	Glycolipid_bind
TLS2_k127_6057066_12	882083.SacmaDRAFT_2733	3.454e-82	295.0	COG0644@1|root,COG0644@2|Bacteria,2GNH7@201174|Actinobacteria,4E8RQ@85010|Pseudonocardiales	201174|Actinobacteria	C	Lycopene cyclase protein	crtY	-	5.5.1.19	ko:K06443	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R03824,R04801,R05341,R06962,R07856	RC01004,RC01964	ko00000,ko00001,ko00002,ko01000	-	-	-	Lycopene_cycl
TLS2_k127_6057066_15	479435.Kfla_0243	2.317e-67	240.0	COG3103@1|root,COG3103@2|Bacteria,2I3RJ@201174|Actinobacteria,4DR7V@85009|Propionibacteriales	201174|Actinobacteria	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
TLS2_k127_6057066_22	479431.Namu_3635	2.813e-39	150.0	COG1846@1|root,COG1917@1|root,COG1846@2|Bacteria,COG1917@2|Bacteria,2GQ94@201174|Actinobacteria,4ESRT@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulator, MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS2_k127_6057066_21	219305.MCAG_04079	6.41e-40	151.0	COG0662@1|root,COG0662@2|Bacteria,2II1B@201174|Actinobacteria,4DDJ1@85008|Micromonosporales	201174|Actinobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_6057066_7	1146883.BLASA_0807	4.235e-114	373.0	COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria,4ESR2@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
TLS2_k127_6057066_9	1123024.AUII01000008_gene1846	2.436e-107	356.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4DY81@85010|Pseudonocardiales	201174|Actinobacteria	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	cobB	-	-	-	-	-	-	-	-	-	-	-	SIR2
TLS2_k127_6057066_3	1869.MB27_28220	1.643e-188	597.0	COG0435@1|root,COG0435@2|Bacteria,2GIXK@201174|Actinobacteria,4D99G@85008|Micromonosporales	201174|Actinobacteria	O	Glutathione S-transferase, C-terminal domain	yqjG	-	1.8.5.7	ko:K07393	-	-	-	-	ko00000,ko01000	-	-	-	GST_C_2,GST_N_2
TLS2_k127_6057066_16	266940.Krad_0785	4.593e-66	235.0	COG2258@1|root,COG2258@2|Bacteria,2GMBE@201174|Actinobacteria	201174|Actinobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
TLS2_k127_6057066_20	1125971.ASJB01000055_gene6800	3.184e-41	156.0	COG1051@1|root,COG1051@2|Bacteria,2GTC8@201174|Actinobacteria,4EBU7@85010|Pseudonocardiales	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_6057066_8	1449346.JQMO01000002_gene1641	1.42e-108	357.0	COG0596@1|root,COG0596@2|Bacteria,2H406@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_6057066_23	2074.JNYD01000032_gene6493	2.578e-25	115.0	2BVHN@1|root,332R2@2|Bacteria,2IPM7@201174|Actinobacteria,4EBR7@85010|Pseudonocardiales	201174|Actinobacteria	S	Pfam:DUF385	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS2_k127_6057066_2	1123320.KB889708_gene8316	1.266e-210	660.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS2_k127_6057066_1	1246995.AFR_25175	4.755e-233	738.0	COG0793@1|root,COG0793@2|Bacteria,2HFZM@201174|Actinobacteria	201174|Actinobacteria	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
TLS2_k127_6057066_24	1121272.KB903249_gene1781	1.801e-17	83.0	COG1835@1|root,COG1835@2|Bacteria,2GKUS@201174|Actinobacteria,4DFGJ@85008|Micromonosporales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS2_k127_6074174_20	1206101.AZXC01000001_gene4719	3.509e-07	62.0	29WIN@1|root,30I4V@2|Bacteria,2HFE7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6074174_2	1386089.N865_11795	1.375e-195	637.0	COG0455@1|root,COG1994@1|root,COG0455@2|Bacteria,COG1994@2|Bacteria,2GMK0@201174|Actinobacteria,4FGIH@85021|Intrasporangiaceae	201174|Actinobacteria	D	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
TLS2_k127_6074174_14	477641.MODMU_2489	7.164e-53	196.0	COG3629@1|root,COG3629@2|Bacteria,2IC17@201174|Actinobacteria,4EVRF@85013|Frankiales	201174|Actinobacteria	T	DNA-binding transcriptional activator of the SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
TLS2_k127_6074174_15	1337093.MBE-LCI_2629	1.212e-43	170.0	COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2U7H5@28211|Alphaproteobacteria,2P8YX@245186|Loktanella	28211|Alphaproteobacteria	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
TLS2_k127_6074174_17	1449976.KALB_801	3.098e-27	123.0	COG0457@1|root,COG0457@2|Bacteria,2I3MN@201174|Actinobacteria,4E4BA@85010|Pseudonocardiales	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
TLS2_k127_6074174_0	369723.Strop_1732	0.0	1299.0	COG4581@1|root,COG4581@2|Bacteria,2GJSV@201174|Actinobacteria,4D93J@85008|Micromonosporales	201174|Actinobacteria	L	DEAD DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DUF3516,Helicase_C
TLS2_k127_6074174_4	1120950.KB892801_gene1748	4.111e-178	565.0	COG1623@1|root,COG1623@2|Bacteria,2GJ41@201174|Actinobacteria,4DNMZ@85009|Propionibacteriales	201174|Actinobacteria	L	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process	disA	-	2.7.7.85	ko:K07067	-	-	-	-	ko00000,ko01000	-	-	-	DisA-linker,DisA_N,HHH,HHH_2
TLS2_k127_6074174_3	1003195.SCAT_2608	1.615e-186	593.0	COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria	201174|Actinobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
TLS2_k127_6074174_10	1121272.KB903290_gene4684	1.375e-78	278.0	2CBE1@1|root,32RT5@2|Bacteria,2IQDS@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6074174_9	1120936.KB907213_gene4857	3.921e-80	274.0	COG0500@1|root,COG2226@2|Bacteria,2GQ64@201174|Actinobacteria,4EFW5@85012|Streptosporangiales	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_6074174_7	479433.Caci_8358	1.553e-112	368.0	28IRH@1|root,2Z8QX@2|Bacteria,2GJW6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6074174_18	1003195.SCAT_2604	2.504e-10	69.0	COG0248@1|root,COG0248@2|Bacteria,2GMME@201174|Actinobacteria	201174|Actinobacteria	FP	Ppx GppA phosphatase	ppx1	GO:0003674,GO:0003824,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
TLS2_k127_6074174_6	1003195.SCAT_2603	6.952e-117	383.0	COG1082@1|root,COG1082@2|Bacteria,2GJ6E@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_6074174_13	1944.JOAZ01000022_gene3228	1.392e-59	213.0	COG1309@1|root,COG1309@2|Bacteria,2GP92@201174|Actinobacteria,4184J@629295|Streptomyces griseus group	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_6074174_16	1463825.JNXC01000011_gene254	2.836e-37	155.0	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria,4E10P@85010|Pseudonocardiales	201174|Actinobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
TLS2_k127_6074174_5	393305.YE2500	3.983e-117	386.0	COG2066@1|root,COG2066@2|Bacteria,1MWB5@1224|Proteobacteria,1RMY9@1236|Gammaproteobacteria,41ENZ@629|Yersinia	1236|Gammaproteobacteria	E	Belongs to the glutaminase family	glsA	GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009987,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase
TLS2_k127_6074174_1	469383.Cwoe_3624	2.854e-226	737.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4CR8Y@84995|Rubrobacteria	84995|Rubrobacteria	T	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
TLS2_k127_6074174_11	1123258.AQXZ01000016_gene2293	1.987e-69	248.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS2_k127_6074174_12	1283299.AUKG01000002_gene4675	2.838e-68	240.0	COG2197@1|root,COG2197@2|Bacteria,2HQF1@201174|Actinobacteria,4CRZT@84995|Rubrobacteria	84995|Rubrobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_6074174_8	1283299.AUKG01000002_gene4674	4.932e-96	336.0	COG4585@1|root,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria,4CSC0@84995|Rubrobacteria	84995|Rubrobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS2_k127_6076588_0	28444.JODQ01000001_gene2070	8.591e-150	490.0	COG0683@1|root,COG0683@2|Bacteria,2GM00@201174|Actinobacteria,4EFRW@85012|Streptosporangiales	201174|Actinobacteria	E	Receptor family ligand binding region	livK	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_6076588_2	1035308.AQYY01000001_gene3409	1.205e-26	126.0	COG0683@1|root,COG0683@2|Bacteria,1TSDD@1239|Firmicutes,2483T@186801|Clostridia,261BJ@186807|Peptococcaceae	186801|Clostridia	E	ABC-type branched-chain amino acid transport	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_6076588_1	1449355.JQNR01000003_gene154	2.651e-86	290.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
TLS2_k127_6136212_15	472175.EL18_00534	2.129e-19	90.0	COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,2UBYD@28211|Alphaproteobacteria,43KDI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	phosphohistidine phosphatase, SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
TLS2_k127_6136212_0	1120950.KB892708_gene4348	2.681e-163	522.0	COG0560@1|root,COG0560@2|Bacteria,2GJDH@201174|Actinobacteria,4DN8I@85009|Propionibacteriales	201174|Actinobacteria	E	phosphoserine phosphatase	serB	GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	iNJ661.Rv3042c	ACT_6,HAD
TLS2_k127_6136212_12	479433.Caci_2312	1.093e-48	186.0	2BK9Y@1|root,32EQ4@2|Bacteria,2GMZH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6136212_6	479435.Kfla_3702	8.749e-114	383.0	COG1119@1|root,COG1119@2|Bacteria,2GIXX@201174|Actinobacteria,4DNDT@85009|Propionibacteriales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	ylmA	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
TLS2_k127_6136212_14	1120950.KB892708_gene4358	8.903e-45	168.0	COG1585@1|root,COG1585@2|Bacteria,2IHZU@201174|Actinobacteria,4DRK6@85009|Propionibacteriales	201174|Actinobacteria	OU	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
TLS2_k127_6136212_4	1120950.KB892708_gene4359	2.605e-133	442.0	COG0330@1|root,COG0330@2|Bacteria,2GJ1U@201174|Actinobacteria,4DN0Q@85009|Propionibacteriales	201174|Actinobacteria	O	prohibitin homologues	hflK	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_6136212_19	1380393.JHVP01000012_gene2743	5.598e-05	54.0	COG3046@1|root,COG3046@2|Bacteria,2GMF6@201174|Actinobacteria,4ES4S@85013|Frankiales	201174|Actinobacteria	S	deoxyribodipyrimidine photolyase-related protein	cry1	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP,FAD_binding_7
TLS2_k127_6136212_5	397278.JOJN01000003_gene1817	2.844e-116	385.0	COG3046@1|root,COG3046@2|Bacteria,2GMF6@201174|Actinobacteria,4DPUH@85009|Propionibacteriales	201174|Actinobacteria	S	Deoxyribodipyrimidine photo-lyase-related protein	cry1	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP,FAD_binding_7
TLS2_k127_6136212_10	105425.BBPL01000066_gene5372	1.05e-80	285.0	COG0730@1|root,COG0730@2|Bacteria,2GJCC@201174|Actinobacteria,2NF3Z@228398|Streptacidiphilus	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_6136212_1	1163617.SCD_n00051	1.731e-144	491.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,2VIF1@28216|Betaproteobacteria	28216|Betaproteobacteria	C	acetyl-CoA hydrolase	-	-	-	ko:K18288	ko00660,map00660	-	R02407,R10600	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
TLS2_k127_6136212_16	1303692.SFUL_4393	6.754e-10	64.0	COG1278@1|root,COG1278@2|Bacteria,2GY4A@201174|Actinobacteria	201174|Actinobacteria	K	Cold shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_6136212_7	1120950.KB892708_gene4366	3.646e-98	331.0	COG0566@1|root,COG0566@2|Bacteria,2GJ12@201174|Actinobacteria,4DN3T@85009|Propionibacteriales	201174|Actinobacteria	J	SpoU rRNA Methylase family	spoU2	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
TLS2_k127_6136212_2	1122247.C731_2332	1.045e-143	462.0	COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,23456@1762|Mycobacteriaceae	201174|Actinobacteria	S	alcohol dehydrogenase	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_6136212_18	710111.FraQA3DRAFT_2952	1.528e-07	55.0	2B143@1|root,2ZS6C@2|Bacteria,2HUXY@201174|Actinobacteria,4EWPV@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6136212_8	326424.FRAAL6052	5.838e-95	334.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria,4ERT1@85013|Frankiales	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
TLS2_k127_6136212_9	471857.Svir_24850	4.811e-81	279.0	COG1051@1|root,COG1051@2|Bacteria,2I2YK@201174|Actinobacteria,4E3FE@85010|Pseudonocardiales	201174|Actinobacteria	F	ADP-ribose pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_6136212_11	1463936.JOJI01000024_gene1270	9.028e-65	231.0	COG0490@1|root,COG0490@2|Bacteria,2IFBQ@201174|Actinobacteria	201174|Actinobacteria	P	regulatory, ligand-binding protein related to C-terminal domains of K channels	-	-	-	ko:K07228	-	-	-	-	ko00000	-	-	-	TrkA_C
TLS2_k127_6136212_3	526225.Gobs_2800	1.835e-140	456.0	COG0475@1|root,COG0475@2|Bacteria,2GJ69@201174|Actinobacteria,4ES2U@85013|Frankiales	201174|Actinobacteria	P	PFAM sodium hydrogen exchanger	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
TLS2_k127_6136212_17	1283299.AUKG01000006_gene821	8.381e-08	63.0	29JYD@1|root,306VN@2|Bacteria,2GWXT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6136212_13	1122138.AQUZ01000005_gene2670	3.26e-45	172.0	2BIEE@1|root,32T9G@2|Bacteria,2I86Y@201174|Actinobacteria,4DWJ9@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6169559_1	2074.JNYD01000003_gene3740	1.379e-09	60.0	COG3547@1|root,COG3547@2|Bacteria,2HJ5P@201174|Actinobacteria,4E8DQ@85010|Pseudonocardiales	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TLS2_k127_6169559_0	1121924.ATWH01000011_gene223	1.62e-148	487.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4FK54@85023|Microbacteriaceae	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
TLS2_k127_6169559_2	675635.Psed_6852	3.726e-05	47.0	COG3462@1|root,COG3462@2|Bacteria,2GWIQ@201174|Actinobacteria,4E7TB@85010|Pseudonocardiales	201174|Actinobacteria	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
TLS2_k127_6174724_3	1246995.AFR_37850	3.086e-32	137.0	COG0726@1|root,COG0726@2|Bacteria,2GN6G@201174|Actinobacteria	201174|Actinobacteria	G	polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
TLS2_k127_6174724_2	479435.Kfla_2115	1.723e-93	326.0	COG0746@1|root,COG0746@2|Bacteria,2IACX@201174|Actinobacteria	201174|Actinobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TLS2_k127_6174724_1	1123024.AUII01000035_gene1223	2.549e-263	823.0	COG2414@1|root,COG2414@2|Bacteria,2IF1J@201174|Actinobacteria	201174|Actinobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
TLS2_k127_6174724_0	479435.Kfla_2117	0.0	1042.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4DSZJ@85009|Propionibacteriales	201174|Actinobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
TLS2_k127_6188150_3	1894.JOER01000044_gene6714	4.162e-70	241.0	COG3832@1|root,COG3832@2|Bacteria,2IHTJ@201174|Actinobacteria	201174|Actinobacteria	K	Activator of hsp90 atpase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_6188150_5	211114.JOEF01000034_gene1409	1.034e-51	186.0	COG0640@1|root,COG0640@2|Bacteria,2IKQY@201174|Actinobacteria,4E4JT@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Bacterial regulatory protein, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_6188150_2	1120950.KB892742_gene3038	1.065e-128	426.0	COG0477@1|root,COG2814@2|Bacteria,2GK1K@201174|Actinobacteria,4DTNQ@85009|Propionibacteriales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	blt	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_6188150_1	1463936.JOJI01000016_gene218	1.623e-165	543.0	COG0477@1|root,COG1846@1|root,COG0477@2|Bacteria,COG1846@2|Bacteria,2GJ09@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_6188150_7	1380393.JHVP01000010_gene2963	1.593e-10	71.0	COG1846@1|root,COG1846@2|Bacteria,2IQNM@201174|Actinobacteria,4EW73@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulator, MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_6188150_0	1120950.KB892763_gene5544	8.725e-174	554.0	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria,4DN8T@85009|Propionibacteriales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
TLS2_k127_6188150_4	1120950.KB892763_gene5545	1.576e-63	227.0	2B5R0@1|root,31YKI@2|Bacteria,2IPMA@201174|Actinobacteria,4DR93@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6188150_6	1120950.KB892763_gene5546	3.313e-36	152.0	COG3877@1|root,COG3877@2|Bacteria,2IT3M@201174|Actinobacteria,4DVDP@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
TLS2_k127_6191329_4	585531.HMPREF0063_12436	6.458e-92	316.0	COG2234@1|root,COG2234@2|Bacteria,2GIT0@201174|Actinobacteria,4DQCH@85009|Propionibacteriales	201174|Actinobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS2_k127_6191329_3	1172181.KB911724_gene3510	6.031e-165	533.0	COG0686@1|root,COG0686@2|Bacteria,2GKMN@201174|Actinobacteria	201174|Actinobacteria	E	alanine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TLS2_k127_6191329_2	1996.JOFO01000055_gene1158	6.568e-211	669.0	COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria,4EG4N@85012|Streptosporangiales	201174|Actinobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_6191329_0	1120950.KB892762_gene5452	0.0	1111.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,4DPFE@85009|Propionibacteriales	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS2_k127_6191329_6	457425.XNR_2705	2.081e-16	85.0	COG2172@1|root,COG2172@2|Bacteria,2IHNR@201174|Actinobacteria	201174|Actinobacteria	T	anti-sigma regulatory factor	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
TLS2_k127_6191329_5	66377.JOBH01000010_gene6394	2.211e-53	196.0	COG1366@1|root,COG1366@2|Bacteria,2IHQG@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	rsbV	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS2_k127_6191329_1	471852.Tcur_4829	0.0	1038.0	COG0514@1|root,COG1205@1|root,COG0514@2|Bacteria,COG1205@2|Bacteria,2GJJ6@201174|Actinobacteria,4EG7V@85012|Streptosporangiales	201174|Actinobacteria	L	Domain of unknown function (DUF1998)	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
TLS2_k127_6198684_6	526225.Gobs_0310	4.665e-18	89.0	COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria,4ESTY@85013|Frankiales	201174|Actinobacteria	E	PFAM extracellular solute-binding protein family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_6198684_2	1386089.N865_20950	1.795e-112	374.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
TLS2_k127_6198684_4	1120950.KB892747_gene3748	3.268e-44	176.0	COG0739@1|root,COG0739@2|Bacteria,2IQ64@201174|Actinobacteria,4DR63@85009|Propionibacteriales	201174|Actinobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_6198684_1	196162.Noca_3245	1.471e-127	417.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4DN7T@85009|Propionibacteriales	201174|Actinobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_6198684_3	1123321.KB905825_gene58	8.243e-91	316.0	COG0758@1|root,COG0758@2|Bacteria,2GKDA@201174|Actinobacteria	201174|Actinobacteria	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
TLS2_k127_6198684_0	1120950.KB892769_gene5381	1.455e-174	571.0	COG0606@1|root,COG0606@2|Bacteria,2GJIQ@201174|Actinobacteria,4DNC3@85009|Propionibacteriales	201174|Actinobacteria	O	Magnesium chelatase, subunit ChlI C-terminal	comM	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
TLS2_k127_6198684_5	1120950.KB892769_gene5382	2.758e-41	157.0	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4DRQN@85009|Propionibacteriales	201174|Actinobacteria	L	Belongs to the UPF0102 family	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
TLS2_k127_6212_6	1120950.KB892707_gene4598	2.864e-42	165.0	COG4636@1|root,COG4636@2|Bacteria,2IGTR@201174|Actinobacteria,4DRGB@85009|Propionibacteriales	201174|Actinobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS2_k127_6212_1	882083.SacmaDRAFT_2111	5.035e-100	340.0	COG1171@1|root,COG1171@2|Bacteria,2H1VX@201174|Actinobacteria	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
TLS2_k127_6212_7	298655.KI912266_gene3375	3.542e-39	169.0	COG4585@1|root,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria,4ESVV@85013|Frankiales	201174|Actinobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_6212_4	1385521.N803_14695	4.604e-61	222.0	COG2197@1|root,COG2197@2|Bacteria,2GM61@201174|Actinobacteria,4FJUZ@85021|Intrasporangiaceae	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_6212_3	471853.Bcav_0988	3.562e-66	230.0	COG4636@1|root,COG4636@2|Bacteria,2IGTR@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS2_k127_6212_0	710696.Intca_0141	1.665e-246	770.0	COG3033@1|root,COG3033@2|Bacteria,2GKH3@201174|Actinobacteria,4FIY8@85021|Intrasporangiaceae	201174|Actinobacteria	E	Beta-eliminating lyase	tnaA	-	4.1.99.1,4.1.99.2	ko:K01667,ko:K01668	ko00350,ko00380,map00350,map00380	-	R00673,R00728	RC00209,RC00355,RC00364	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_6212_5	1122182.KB903833_gene5510	4.16e-51	194.0	COG1136@1|root,COG1136@2|Bacteria,2IENJ@201174|Actinobacteria,4DBFF@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	ytrE	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6212_2	1122182.KB903833_gene5511	2.818e-77	284.0	COG1136@1|root,COG1136@2|Bacteria,2GIV7@201174|Actinobacteria,4DAZG@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_6212_8	35754.JNYJ01000036_gene3642	4.362e-21	107.0	COG0577@1|root,COG0577@2|Bacteria,2HWDA@201174|Actinobacteria,4D9PY@85008|Micromonosporales	201174|Actinobacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6238953_0	1095767.CAHD01000080_gene2714	7.04e-164	518.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4F117@85016|Cellulomonadaceae	201174|Actinobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS2_k127_6238953_1	1380393.JHVP01000004_gene585	1.292e-59	214.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4ESGX@85013|Frankiales	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_6246796_1	1120959.ATXF01000010_gene185	4.559e-96	331.0	COG0671@1|root,COG0671@2|Bacteria,2I8WW@201174|Actinobacteria	201174|Actinobacteria	I	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS2_k127_6246796_0	1120950.KB892766_gene5091	0.0	1153.0	COG1032@1|root,COG1032@2|Bacteria,2GJY1@201174|Actinobacteria,4DNWJ@85009|Propionibacteriales	201174|Actinobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_6246796_2	1122138.AQUZ01000017_gene6534	7.431e-86	294.0	COG5011@1|root,COG5011@2|Bacteria,2GIS7@201174|Actinobacteria,4DQ75@85009|Propionibacteriales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2344)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344
TLS2_k127_624848_5	1464048.JNZS01000029_gene1785	7.97e-78	276.0	COG0189@1|root,COG0189@2|Bacteria,2HI2Z@201174|Actinobacteria,4DBDA@85008|Micromonosporales	201174|Actinobacteria	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	GSH-S_ATP
TLS2_k127_624848_0	1122182.KB903814_gene3583	1.578e-241	769.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DB05@85008|Micromonosporales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	fadD4	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_624848_3	211114.JOEF01000004_gene6505	1.016e-95	333.0	COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria,4DXV2@85010|Pseudonocardiales	201174|Actinobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_624848_4	1120950.KB892812_gene7005	3.317e-95	333.0	COG0388@1|root,COG0388@2|Bacteria,2GMQA@201174|Actinobacteria,4DNQW@85009|Propionibacteriales	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
TLS2_k127_624848_6	1137269.AZWL01000047_gene3602	7.662e-19	94.0	COG0746@1|root,COG0746@2|Bacteria,2GJVE@201174|Actinobacteria	201174|Actinobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
TLS2_k127_624848_2	882086.SacxiDRAFT_3018	9.498e-107	353.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4E1EY@85010|Pseudonocardiales	201174|Actinobacteria	KT	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_624848_1	1122138.AQUZ01000016_gene289	2.299e-130	432.0	COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria,4DWXU@85009|Propionibacteriales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_6250405_3	1120950.KB892742_gene3023	2.882e-31	124.0	COG1461@1|root,COG1461@2|Bacteria,2HEQ9@201174|Actinobacteria,4DQSR@85009|Propionibacteriales	201174|Actinobacteria	S	Dak2	dhaL	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
TLS2_k127_6250405_1	1120950.KB892742_gene3022	4.498e-176	557.0	COG2376@1|root,COG2376@2|Bacteria,2GJV9@201174|Actinobacteria,4DN06@85009|Propionibacteriales	201174|Actinobacteria	G	Dihydroxyacetone kinase	dhaK	-	2.7.1.121	ko:K05878	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak1
TLS2_k127_6250405_0	1033730.CAHG01000008_gene3135	7.823e-177	564.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4DMZ8@85009|Propionibacteriales	201174|Actinobacteria	E	Peptidase dimerisation domain	argE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_6250405_2	263358.VAB18032_15305	6.978e-94	316.0	COG1246@1|root,COG1246@2|Bacteria,2ICRQ@201174|Actinobacteria,4DA55@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Imp-YgjV
TLS2_k127_6271432_5	1122237.AUGQ01000006_gene21	3.088e-12	69.0	COG1070@1|root,COG1070@2|Bacteria,2GNCR@201174|Actinobacteria,4FKY0@85023|Microbacteriaceae	201174|Actinobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	-	R01737	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
TLS2_k127_6271432_1	1146883.BLASA_3775	1.976e-71	250.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS2_k127_6271432_3	1283287.KB822577_gene3207	2.915e-47	182.0	COG2197@1|root,COG2197@2|Bacteria,2GSEU@201174|Actinobacteria,4DTUU@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_6271432_2	253839.SSNG_03324	1.102e-58	214.0	2BG1F@1|root,329XM@2|Bacteria,2I8BC@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3151)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3151
TLS2_k127_6271432_0	266940.Krad_4124	3.524e-179	566.0	COG0191@1|root,COG0191@2|Bacteria,2GM5P@201174|Actinobacteria	201174|Actinobacteria	G	fructose-bisphosphate aldolase	fba	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
TLS2_k127_6271432_4	1449976.KALB_2720	7.042e-25	107.0	COG1925@1|root,COG1925@2|Bacteria,2GQX6@201174|Actinobacteria,4E63H@85010|Pseudonocardiales	201174|Actinobacteria	G	TIGRFAM Phosphotransferase System HPr (HPr) Family	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
TLS2_k127_6271432_6	593907.Celgi_2206	4.035e-07	52.0	COG1080@1|root,COG1080@2|Bacteria,2GIZZ@201174|Actinobacteria,4F207@85016|Cellulomonadaceae	201174|Actinobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
TLS2_k127_6271730_2	68170.KL590473_gene4537	4.054e-75	260.0	COG2304@1|root,COG2304@2|Bacteria,2GUB3@201174|Actinobacteria,4E1CP@85010|Pseudonocardiales	201174|Actinobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11,VWA
TLS2_k127_6271730_1	479435.Kfla_2123	3.374e-88	314.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	3.6.3.55	ko:K06857,ko:K10112	ko02010,map02010	M00186,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
TLS2_k127_6271730_4	909663.KI867150_gene1537	3.65e-49	194.0	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,42N6T@68525|delta/epsilon subdivisions,2WMKR@28221|Deltaproteobacteria,2MQC8@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
TLS2_k127_6271730_0	479435.Kfla_2121	1.182e-97	325.0	COG2998@1|root,COG2998@2|Bacteria,2IHMF@201174|Actinobacteria	201174|Actinobacteria	H	PBP superfamily domain	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
TLS2_k127_6271730_3	710111.FraQA3DRAFT_2687	1.596e-54	203.0	COG1725@1|root,COG1910@1|root,COG1725@2|Bacteria,COG1910@2|Bacteria,2H32X@201174|Actinobacteria,4ETSA@85013|Frankiales	201174|Actinobacteria	K	PBP superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	GntR,PBP_like
TLS2_k127_6271730_5	479435.Kfla_2120	3.895e-37	141.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,2GJC3@201174|Actinobacteria,4DNAW@85009|Propionibacteriales	201174|Actinobacteria	H	MoeA domain protein domain I and II	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
TLS2_k127_6283344_2	1120950.KB892709_gene4163	1.17e-14	75.0	COG4758@1|root,COG4758@2|Bacteria,2I8FE@201174|Actinobacteria,4DQZ7@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF1707)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF1707,DUF2154
TLS2_k127_6283344_0	263358.VAB18032_25240	2.644e-34	143.0	COG4758@1|root,COG4758@2|Bacteria,2GMRP@201174|Actinobacteria,4DM7C@85008|Micromonosporales	201174|Actinobacteria	S	Cell wall-active antibiotics response 4TMS YvqF	-	-	-	-	-	-	-	-	-	-	-	-	DUF1707,DUF2154
TLS2_k127_6283344_1	452652.KSE_47840	7.458e-21	102.0	2EID2@1|root,33C4E@2|Bacteria,2IG1H@201174|Actinobacteria,2M3AU@2063|Kitasatospora	201174|Actinobacteria	S	Protein of unknown function (DUF4245)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4245
TLS2_k127_6285386_1	479435.Kfla_0436	1.84e-100	344.0	COG2057@1|root,COG2057@2|Bacteria,2GKV9@201174|Actinobacteria,4DNXM@85009|Propionibacteriales	201174|Actinobacteria	I	Coenzyme A transferase	-	-	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS2_k127_6285386_0	479435.Kfla_0437	6.645e-120	389.0	COG1788@1|root,COG1788@2|Bacteria,2GK61@201174|Actinobacteria,4DMXZ@85009|Propionibacteriales	201174|Actinobacteria	I	Coenzyme A transferase	-	-	2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS2_k127_6285386_2	1120950.KB892759_gene6278	1.64e-27	118.0	COG0318@1|root,COG0318@2|Bacteria,2GIX4@201174|Actinobacteria,4DRZ1@85009|Propionibacteriales	201174|Actinobacteria	IQ	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
TLS2_k127_6295120_1	1380370.JIBA01000016_gene631	8.903e-217	679.0	COG0213@1|root,COG0213@2|Bacteria,2GJH5@201174|Actinobacteria,4FETB@85021|Intrasporangiaceae	201174|Actinobacteria	F	pyrimidine-nucleoside phosphorylase	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
TLS2_k127_6295120_2	106370.Francci3_0218	1.24e-81	282.0	COG2172@1|root,COG2172@2|Bacteria,2GKU6@201174|Actinobacteria,4ESWM@85013|Frankiales	201174|Actinobacteria	T	MEDS: MEthanogen/methylotroph, DcmR Sensory domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,MEDS
TLS2_k127_6295120_0	292415.Tbd_1072	3.912e-249	779.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VS7B@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2
TLS2_k127_629942_0	1123320.KB889692_gene176	2.82e-119	392.0	COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria	201174|Actinobacteria	E	HAD-superfamily subfamily IB hydrolase, TIGR01490	serB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	HAD
TLS2_k127_6317613_1	1048339.KB913029_gene1984	1.302e-81	280.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,4ES3X@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
TLS2_k127_6317613_0	1120950.KB892812_gene6972	2.005e-226	711.0	COG0362@1|root,COG0362@2|Bacteria,2GJ2J@201174|Actinobacteria,4DQ33@85009|Propionibacteriales	201174|Actinobacteria	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
TLS2_k127_6317613_2	1123251.ATWM01000003_gene1257	3.374e-65	234.0	2DBB1@1|root,2Z854@2|Bacteria,2GNBN@201174|Actinobacteria,4FEXB@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of Unknown Function (DUF1206)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1206
TLS2_k127_6322300_1	1120950.KB892765_gene5672	1.791e-78	284.0	COG4279@1|root,COG4279@2|Bacteria,2GIYW@201174|Actinobacteria,4DU1P@85009|Propionibacteriales	201174|Actinobacteria	S	SWIM zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
TLS2_k127_6322300_0	1120950.KB892765_gene5673	1.109e-127	412.0	COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,4DTEN@85009|Propionibacteriales	201174|Actinobacteria	L	SNF2 Helicase protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
TLS2_k127_6322443_0	1394178.AWOO02000070_gene325	0.0	1354.0	COG1643@1|root,COG1643@2|Bacteria,2GIWX@201174|Actinobacteria,4EGY7@85012|Streptosporangiales	201174|Actinobacteria	L	Helicase associated domain (HA2)  Add an annotation	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
TLS2_k127_6322443_1	44060.JODL01000011_gene1978	1.045e-180	582.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,2I8V5@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
TLS2_k127_6322443_3	263358.VAB18032_18735	0.000442	53.0	COG0490@1|root,COG0490@2|Bacteria,2IQQA@201174|Actinobacteria	201174|Actinobacteria	P	domain, Protein	-	-	-	ko:K07228	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_6322443_2	1336235.JAEG01000012_gene4153	4.92e-57	212.0	COG0160@1|root,COG2334@1|root,COG0160@2|Bacteria,COG2334@2|Bacteria,1R4DI@1224|Proteobacteria,2VETD@28211|Alphaproteobacteria,4B868@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH,Aminotran_3
TLS2_k127_6326296_1	1120950.KB892741_gene2685	2.006e-124	405.0	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria,4DPHV@85009|Propionibacteriales	201174|Actinobacteria	Q	Domain of unknown function (DUF2437)	fahA	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
TLS2_k127_6326296_0	1449353.JQMQ01000005_gene2063	3.22e-228	717.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,2NEZ8@228398|Streptacidiphilus	201174|Actinobacteria	J	tRNA synthetases class I (E and Q), catalytic domain	gltX	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	iNJ661.Rv2992c	tRNA-synt_1c
TLS2_k127_6326296_2	1380347.JNII01000007_gene689	1.116e-47	185.0	COG1266@1|root,COG1266@2|Bacteria,2IIE6@201174|Actinobacteria	201174|Actinobacteria	F	CAAX amino terminal protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_6328864_18	1298863.AUEP01000020_gene3612	1.912e-21	97.0	COG2909@1|root,COG2909@2|Bacteria,2I50W@201174|Actinobacteria,4DPMG@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE
TLS2_k127_6328864_19	1444309.JAQG01000091_gene1341	6.591e-06	53.0	COG2909@1|root,COG2909@2|Bacteria,1UIMV@1239|Firmicutes,4HD7H@91061|Bacilli,26QDM@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
TLS2_k127_6328864_3	1380386.JIAW01000003_gene578	5.802e-195	639.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,235YH@1762|Mycobacteriaceae	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_6328864_17	2074.JNYD01000055_gene2330	5.881e-34	137.0	2C82G@1|root,32RK9@2|Bacteria,2IRVD@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
TLS2_k127_6328864_8	479435.Kfla_3168	3.954e-76	269.0	COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4DQ8M@85009|Propionibacteriales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA2	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_6328864_1	1123320.KB889562_gene6872	0.0	1151.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria	201174|Actinobacteria	JM	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
TLS2_k127_6328864_11	1120950.KB892707_gene5029	1.137e-56	210.0	COG3879@1|root,COG3879@2|Bacteria,2GMS5@201174|Actinobacteria,4DR0G@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF881)	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF881
TLS2_k127_6328864_15	1385518.N798_07755	1.725e-40	165.0	COG3856@1|root,COG3856@2|Bacteria,2IKJW@201174|Actinobacteria,4FGYG@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	sbp	-	-	-	-	-	-	-	-	-	-	-	DUF1290
TLS2_k127_6328864_10	1120950.KB892707_gene5031	5.717e-61	221.0	COG3879@1|root,COG3879@2|Bacteria,2GJ3C@201174|Actinobacteria,4DR07@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF881)	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF881
TLS2_k127_6328864_12	1122609.AUGT01000003_gene2134	1.045e-55	199.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4DR4B@85009|Propionibacteriales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iNJ661.Rv1826	GCV_H
TLS2_k127_6328864_9	479435.Kfla_3173	7.048e-65	228.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4DR1A@85009|Propionibacteriales	201174|Actinobacteria	T	zinc-ribbon domain	garA	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
TLS2_k127_6328864_6	1120950.KB892707_gene5034	1.049e-80	276.0	COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria,4DQDI@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	merR1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1
TLS2_k127_6328864_7	1048339.KB913029_gene4118	8.292e-78	262.0	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,4ESIT@85013|Frankiales	201174|Actinobacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
TLS2_k127_6328864_5	1048339.KB913029_gene4119	4.642e-82	288.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,4ESCD@85013|Frankiales	201174|Actinobacteria	K	SMART regulatory protein, MerR	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS2_k127_6328864_0	1120934.KB894416_gene4091	0.0	1399.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria,4DXCZ@85010|Pseudonocardiales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
TLS2_k127_6328864_16	1146883.BLASA_1743	2.332e-35	150.0	2CIBE@1|root,32S7P@2|Bacteria,2IRU5@201174|Actinobacteria,4ET6C@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6328864_4	1463881.KL591005_gene5993	1.132e-174	563.0	COG0312@1|root,COG0312@2|Bacteria,2GZPS@201174|Actinobacteria	201174|Actinobacteria	S	modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
TLS2_k127_6328864_2	1120950.KB892708_gene4185	1.677e-241	754.0	COG0312@1|root,COG0312@2|Bacteria,2GJ4E@201174|Actinobacteria,4DP14@85009|Propionibacteriales	201174|Actinobacteria	S	Putative modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS2_k127_6328864_14	1120950.KB892708_gene4193	4.106e-49	180.0	COG5083@1|root,COG5083@2|Bacteria,2IFC7@201174|Actinobacteria,4DUZK@85009|Propionibacteriales	201174|Actinobacteria	S	phosphatidylinositol transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Acid_phosphat_B
TLS2_k127_6328864_13	1123320.KB889618_gene7128	1.288e-49	182.0	COG0726@1|root,COG0726@2|Bacteria,2GN6G@201174|Actinobacteria	201174|Actinobacteria	G	polysaccharide deacetylase	-	-	3.5.1.104	ko:K14659,ko:K22278	-	M00664	-	-	ko00000,ko00002,ko01000	-	-	-	Polysacc_deac_1
TLS2_k127_6357747_8	285514.JNWO01000011_gene8485	1.973e-86	293.0	COG3012@1|root,COG3012@2|Bacteria,2GJ7F@201174|Actinobacteria	201174|Actinobacteria	S	SEC-C motif	-	-	-	-	-	-	-	-	-	-	-	-	SEC-C
TLS2_k127_6357747_11	1048339.KB913029_gene1747	1.077e-78	274.0	COG1215@1|root,COG1215@2|Bacteria,2GMKV@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_6357747_6	471852.Tcur_0118	4.38e-112	393.0	COG3119@1|root,COG3119@2|Bacteria,2H59R@201174|Actinobacteria,4EI9V@85012|Streptosporangiales	201174|Actinobacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6357747_17	1121946.AUAX01000006_gene3507	2.255e-47	179.0	COG2119@1|root,COG2119@2|Bacteria,2GNR0@201174|Actinobacteria,4D8J9@85008|Micromonosporales	201174|Actinobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
TLS2_k127_6357747_4	1120950.KB892812_gene6976	9.972e-125	407.0	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4DN8Z@85009|Propionibacteriales	201174|Actinobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
TLS2_k127_6357747_18	1464048.JNZS01000002_gene552	9.332e-34	145.0	COG0671@1|root,COG0671@2|Bacteria,2I9FB@201174|Actinobacteria,4DD6R@85008|Micromonosporales	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
TLS2_k127_6357747_1	926564.KI911649_gene1714	5.116e-176	574.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4F4AK@85017|Promicromonosporaceae	201174|Actinobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TLS2_k127_6357747_12	2045.KR76_25860	8.946e-74	259.0	COG0561@1|root,COG0561@2|Bacteria,2GP42@201174|Actinobacteria,4DQA6@85009|Propionibacteriales	201174|Actinobacteria	S	Sucrose-6F-phosphate phosphohydrolase	yidA	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
TLS2_k127_6357747_9	1169161.KB897727_gene965	2.672e-85	299.0	COG0673@1|root,COG0673@2|Bacteria,2GMPY@201174|Actinobacteria	201174|Actinobacteria	S	Oxidoreductase	-	-	-	ko:K03810	-	-	-	-	ko00000	-	-	-	GFO_IDH_MocA
TLS2_k127_6357747_5	369723.Strop_3346	1.106e-115	377.0	COG1309@1|root,COG1309@2|Bacteria,2GQBQ@201174|Actinobacteria,4DCV4@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
TLS2_k127_6357747_15	298653.Franean1_3567	2.993e-62	219.0	COG0346@1|root,COG0346@2|Bacteria,2IKP7@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_6357747_10	42256.RradSPS_1883	7.938e-81	282.0	COG1609@1|root,COG1609@2|Bacteria,2GJV7@201174|Actinobacteria,4CSXQ@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
TLS2_k127_6357747_7	1122622.ATWJ01000001_gene2511	1.075e-86	301.0	COG0738@1|root,COG0738@2|Bacteria,2GRCY@201174|Actinobacteria,4FK0S@85021|Intrasporangiaceae	201174|Actinobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_6357747_19	1184609.KILIM_037_00220	2.709e-19	92.0	COG0346@1|root,COG0346@2|Bacteria,2IQJB@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6357747_0	287986.DV20_19195	8.501e-195	623.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4DXBU@85010|Pseudonocardiales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS2_k127_6357747_2	1123024.AUII01000001_gene2832	3.387e-146	478.0	COG0215@1|root,COG0215@2|Bacteria,2GJ4W@201174|Actinobacteria,4E1NY@85010|Pseudonocardiales	201174|Actinobacteria	J	PFAM tRNA synthetases class I (C) catalytic domain	-	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1e
TLS2_k127_6357747_13	1123322.KB904669_gene3538	3.573e-72	254.0	COG0561@1|root,COG0561@2|Bacteria,2GP42@201174|Actinobacteria	201174|Actinobacteria	J	hydrolase	cof	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
TLS2_k127_6357747_14	1120950.KB892812_gene6999	2.993e-67	236.0	291ZT@1|root,2ZPJ4@2|Bacteria,2GR7R@201174|Actinobacteria,4DQTI@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF2587)	bpa	GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369	-	-	-	-	-	-	-	-	-	-	DUF2587
TLS2_k127_6357747_16	644283.Micau_0816	4.453e-53	211.0	COG0454@1|root,COG0456@2|Bacteria,2I9GA@201174|Actinobacteria,4DD5V@85008|Micromonosporales	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_6357747_3	28444.JODQ01000010_gene3162	1.914e-125	408.0	COG0520@1|root,COG0520@2|Bacteria,2GKAF@201174|Actinobacteria,4EGB0@85012|Streptosporangiales	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_6361583_13	446468.Ndas_3300	8.462e-26	121.0	COG0524@1|root,COG0524@2|Bacteria,2GP1C@201174|Actinobacteria,4EG33@85012|Streptosporangiales	201174|Actinobacteria	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS2_k127_6361583_5	479431.Namu_3777	1.664e-98	330.0	COG2313@1|root,COG2313@2|Bacteria,2GK19@201174|Actinobacteria,4ETX3@85013|Frankiales	201174|Actinobacteria	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
TLS2_k127_6361583_0	1120950.KB892768_gene5311	0.0	1104.0	COG0454@1|root,COG1042@1|root,COG0456@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4DN4A@85009|Propionibacteriales	201174|Actinobacteria	CK	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
TLS2_k127_6361583_9	1120950.KB892748_gene3185	1.323e-70	254.0	29850@1|root,2ZVAX@2|Bacteria,2GKR1@201174|Actinobacteria,4DQC6@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6361583_2	1120950.KB892748_gene3186	3.253e-131	429.0	COG1524@1|root,COG1524@2|Bacteria,2GISU@201174|Actinobacteria,4DNS7@85009|Propionibacteriales	201174|Actinobacteria	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_6361583_15	479433.Caci_5300	6.068e-22	104.0	2E61P@1|root,333YK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6361583_10	351607.Acel_1410	7.318e-51	188.0	COG1595@1|root,COG1595@2|Bacteria,2GJUI@201174|Actinobacteria,4ET5G@85013|Frankiales	201174|Actinobacteria	K	RNA polymerase, sigma-24 subunit, ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
TLS2_k127_6361583_11	58344.JOEL01000028_gene208	2.545e-50	204.0	28PUQ@1|root,2ZCFK@2|Bacteria,2GNQM@201174|Actinobacteria	201174|Actinobacteria	S	DNA-binding protein	-	GO:0008150,GO:0040007	-	-	-	-	-	-	-	-	-	-	DUF3071
TLS2_k127_6361583_3	58344.JOEL01000028_gene206	9.2e-124	431.0	COG0277@1|root,COG0277@2|Bacteria,2GJ33@201174|Actinobacteria	201174|Actinobacteria	C	FAD linked oxidase domain protein	gulO	-	1.1.3.8	ko:K00103	ko00053,ko01100,map00053,map01100	M00129	R00647,R03184,R10053	RC00195,RC00346,RC00869	ko00000,ko00001,ko00002,ko01000	-	-	-	ALO,FAD_binding_4
TLS2_k127_6361583_7	1304865.JAGF01000001_gene1048	3.398e-88	306.0	COG0477@1|root,COG2814@2|Bacteria,2GKMQ@201174|Actinobacteria,4F0M1@85016|Cellulomonadaceae	201174|Actinobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_6361583_1	110319.CF8_2403	8.327e-149	481.0	COG0276@1|root,COG0276@2|Bacteria,2GJTQ@201174|Actinobacteria,4DNBP@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
TLS2_k127_6361583_8	29306.JOBE01000019_gene1544	6.207e-85	304.0	COG0483@1|root,COG0483@2|Bacteria,2GJQE@201174|Actinobacteria	201174|Actinobacteria	G	Inositol monophosphatase	suhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043167,GO:0043169,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS2_k127_6361583_6	1120950.KB892748_gene3207	6.017e-98	333.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria,4DQIN@85009|Propionibacteriales	201174|Actinobacteria	CP	ABC-2 family transporter protein	yhaP	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS2_k127_6361583_4	1123320.KB889707_gene7992	3.675e-101	343.0	COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_6361583_12	1048339.KB913029_gene3865	5.548e-44	167.0	2ATJW@1|root,31J3Z@2|Bacteria,2IKN0@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4193)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4193
TLS2_k127_6361583_14	44060.JODL01000012_gene3534	9.624e-25	109.0	2E4C2@1|root,32Z7M@2|Bacteria,2IFS5@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3093)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3093
TLS2_k127_6408330_0	1120950.KB892746_gene3630	1.308e-137	443.0	COG0201@1|root,COG0201@2|Bacteria,2GJ26@201174|Actinobacteria,4DN3Y@85009|Propionibacteriales	201174|Actinobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
TLS2_k127_6408330_2	1122933.JNIY01000003_gene650	7.55e-66	233.0	COG0200@1|root,COG0200@2|Bacteria,2II6M@201174|Actinobacteria,4F16W@85016|Cellulomonadaceae	201174|Actinobacteria	J	Binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
TLS2_k127_6408330_3	1385520.N802_08000	1.858e-22	104.0	COG1841@1|root,COG1841@2|Bacteria,2GQV0@201174|Actinobacteria,4FHRR@85021|Intrasporangiaceae	201174|Actinobacteria	J	Ribosomal protein L30	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
TLS2_k127_6408330_1	1463858.JOHR01000002_gene6003	1.241e-95	314.0	COG0098@1|root,COG0098@2|Bacteria,2GJW8@201174|Actinobacteria	201174|Actinobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
TLS2_k127_6411892_5	1120949.KB903310_gene928	2.808e-42	160.0	2DQ01@1|root,32UN7@2|Bacteria,2IS50@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6411892_9	452652.KSE_44860	3.358e-16	88.0	COG2172@1|root,COG2172@2|Bacteria,2IIE8@201174|Actinobacteria,2M3MQ@2063|Kitasatospora	201174|Actinobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
TLS2_k127_6411892_1	1122611.KB903945_gene1303	7.509e-114	394.0	COG0708@1|root,COG0708@2|Bacteria,2GKEW@201174|Actinobacteria,4EGSA@85012|Streptosporangiales	201174|Actinobacteria	L	Endonuclease/Exonuclease/phosphatase family	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
TLS2_k127_6411892_3	196162.Noca_2748	1.17e-92	317.0	COG0613@1|root,COG0613@2|Bacteria,2IDTP@201174|Actinobacteria	201174|Actinobacteria	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
TLS2_k127_6411892_7	188626.HMPREF0321_2547	4.639e-30	135.0	COG1249@1|root,COG2388@1|root,COG1249@2|Bacteria,COG2388@2|Bacteria,2GJJK@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	dldH5	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_6411892_0	1394178.AWOO02000092_gene1080	7.48e-175	565.0	COG0667@1|root,COG0667@2|Bacteria,2GMT5@201174|Actinobacteria,4EHDM@85012|Streptosporangiales	201174|Actinobacteria	C	Aldo/keto reductase family	yghZ	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
TLS2_k127_6411892_4	1906.SFRA_17685	3.263e-82	280.0	COG0702@1|root,COG0702@2|Bacteria,2GKNN@201174|Actinobacteria	201174|Actinobacteria	GM	epimerase dehydratase	yhfK	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
TLS2_k127_6411892_2	58123.JOFJ01000008_gene525	2.317e-104	350.0	COG2227@1|root,COG2227@2|Bacteria,2I3C3@201174|Actinobacteria,4ER5A@85012|Streptosporangiales	201174|Actinobacteria	H	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_6411892_6	1123024.AUII01000001_gene3060	8.006e-38	156.0	COG0454@1|root,COG0456@2|Bacteria,2GP2T@201174|Actinobacteria,4E7G3@85010|Pseudonocardiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,Acetyltransf_7
TLS2_k127_6411892_8	1449976.KALB_555	2.01e-22	111.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4DZ35@85010|Pseudonocardiales	201174|Actinobacteria	K	DNA-binding transcriptional activator of the SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,NB-ARC,TPR_10,TPR_12,TPR_7,TPR_8,Trans_reg_C
TLS2_k127_6419565_13	1380356.JNIK01000001_gene2149	1.352e-21	98.0	COG2261@1|root,COG2261@2|Bacteria,2IQGM@201174|Actinobacteria,4ETK1@85013|Frankiales	201174|Actinobacteria	S	transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS2_k127_6419565_12	1054860.KB913030_gene4381	3.579e-24	104.0	2E3M2@1|root,32YJA@2|Bacteria,2GQQW@201174|Actinobacteria	201174|Actinobacteria	S	ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3107
TLS2_k127_6419565_6	1123322.KB904635_gene2459	1.728e-81	279.0	COG1309@1|root,COG1309@2|Bacteria,2GVM5@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_6419565_8	457425.XNR_1631	9.347e-58	213.0	COG2267@1|root,COG2267@2|Bacteria,2GM96@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS2_k127_6419565_3	1033730.CAHG01000012_gene2181	3.222e-201	634.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2GJB6@201174|Actinobacteria,4DNCG@85009|Propionibacteriales	201174|Actinobacteria	H	ThiF family	moeB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006732,GO:0006777,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0018130,GO:0019344,GO:0019538,GO:0019637,GO:0019720,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043170,GO:0043207,GO:0043436,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0061605,GO:0070566,GO:0071704,GO:0071944,GO:0075136,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
TLS2_k127_6419565_4	471852.Tcur_2430	2.27e-130	446.0	COG0392@1|root,COG3642@1|root,COG0392@2|Bacteria,COG3642@2|Bacteria,2GMAV@201174|Actinobacteria,4EHD3@85012|Streptosporangiales	201174|Actinobacteria	I	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
TLS2_k127_6419565_11	644283.Micau_5577	1.64e-27	129.0	COG3695@1|root,COG3695@2|Bacteria,2GQMD@201174|Actinobacteria,4DET5@85008|Micromonosporales	201174|Actinobacteria	L	cysteine	-	-	-	-	-	-	-	-	-	-	-	-	DNA_binding_1
TLS2_k127_6419565_1	1120950.KB892749_gene3377	0.0	1154.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GJD0@201174|Actinobacteria,4DPY8@85009|Propionibacteriales	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD3	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS2_k127_6419565_0	1120950.KB892749_gene3376	0.0	1163.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria,4DP1P@85009|Propionibacteriales	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS2_k127_6419565_7	106370.Francci3_3798	1.055e-69	244.0	COG3568@1|root,COG3568@2|Bacteria,2GP3V@201174|Actinobacteria,4EV2P@85013|Frankiales	201174|Actinobacteria	L	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_6419565_5	469371.Tbis_2968	1.331e-106	354.0	COG2816@1|root,COG2816@2|Bacteria,2GJZY@201174|Actinobacteria,4DXT4@85010|Pseudonocardiales	201174|Actinobacteria	L	NADH pyrophosphatase	nudC	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
TLS2_k127_6419565_10	649831.L083_7266	3.93e-28	115.0	COG0695@1|root,COG0695@2|Bacteria,2IQF9@201174|Actinobacteria,4DEXP@85008|Micromonosporales	201174|Actinobacteria	O	Glutaredoxin	-	-	1.20.4.3	ko:K18917	-	-	-	-	ko00000,ko01000	-	-	-	Glutaredoxin
TLS2_k127_6419565_2	1449355.JQNR01000005_gene4138	9.398e-271	851.0	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria	201174|Actinobacteria	L	DNA helicase	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
TLS2_k127_6419565_9	1306174.JODP01000006_gene3756	2.326e-36	139.0	2DMIS@1|root,32RVG@2|Bacteria,2IQ99@201174|Actinobacteria	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB7	-	-	ko:K18958	-	-	-	-	ko00000,ko03000	-	-	-	AT_hook,Whib
TLS2_k127_6419565_15	1116232.AHBF01000130_gene9597	8.774e-06	55.0	2CGEW@1|root,2ZFHP@2|Bacteria,2IMNK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6423036_5	644283.Micau_1325	7.208e-06	58.0	2BYH3@1|root,2Z7SZ@2|Bacteria,2GMTF@201174|Actinobacteria,4D9NM@85008|Micromonosporales	201174|Actinobacteria	S	3-methyladenine DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6423036_4	1089545.KB913037_gene1092	1.329e-06	60.0	2DZNB@1|root,32VEG@2|Bacteria,2GPZ9@201174|Actinobacteria,4E6YU@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6423036_0	29306.JOBE01000010_gene7094	4.224e-140	464.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS2_k127_6423036_3	555779.Dthio_PD3056	2.911e-19	102.0	COG2062@1|root,COG2062@2|Bacteria,1RGWQ@1224|Proteobacteria,42SEE@68525|delta/epsilon subdivisions,2WPM2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM Phosphoglycerate mutase	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
TLS2_k127_6423036_1	1385519.N801_08965	4.207e-47	188.0	COG0657@1|root,COG0657@2|Bacteria,2GNKU@201174|Actinobacteria,4FHBB@85021|Intrasporangiaceae	201174|Actinobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS2_k127_6423036_2	1463820.JOGW01000022_gene322	2.75e-41	159.0	COG2197@1|root,COG2197@2|Bacteria,2IBK0@201174|Actinobacteria	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_646100_2	29306.JOBE01000029_gene1977	5.185e-96	328.0	COG1482@1|root,COG1482@2|Bacteria,2GJXC@201174|Actinobacteria	201174|Actinobacteria	G	mannose-6-phosphate isomerase	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
TLS2_k127_646100_0	1120950.KB892707_gene4586	7.889e-287	891.0	COG1506@1|root,COG1506@2|Bacteria,2GJW4@201174|Actinobacteria,4DTZJ@85009|Propionibacteriales	201174|Actinobacteria	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
TLS2_k127_646100_1	1120950.KB892707_gene4587	8.976e-241	760.0	COG1199@1|root,COG1199@2|Bacteria,2GKT8@201174|Actinobacteria,4DN8C@85009|Propionibacteriales	201174|Actinobacteria	KL	HELICc2	dinG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
TLS2_k127_646100_4	1121017.AUFG01000030_gene477	2.122e-28	116.0	2DNW5@1|root,32ZGI@2|Bacteria,2IQ5T@201174|Actinobacteria,4FH9S@85021|Intrasporangiaceae	201174|Actinobacteria	S	Rho termination factor, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Rho_N
TLS2_k127_646100_3	110319.CF8_2052	4.347e-44	171.0	COG0730@1|root,COG0730@2|Bacteria,2GPQV@201174|Actinobacteria	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
TLS2_k127_646100_5	1120950.KB892746_gene3588	4.903e-22	108.0	2B5Z6@1|root,31YVD@2|Bacteria,2H1B0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PKD
TLS2_k127_647564_6	446466.Cfla_3145	7.409e-66	251.0	COG0204@1|root,COG0204@2|Bacteria,2IA3W@201174|Actinobacteria	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_647564_4	446469.Sked_19590	2.572e-117	395.0	COG0575@1|root,COG0575@2|Bacteria,2I9PE@201174|Actinobacteria	201174|Actinobacteria	I	Cytidylyltransferase family	cdsA_1	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TLS2_k127_647564_8	710685.MycrhN_6322	1.771e-54	198.0	COG0558@1|root,COG0558@2|Bacteria,2I9CP@201174|Actinobacteria,2374K@1762|Mycobacteriaceae	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_647564_14	1101188.KI912155_gene3688	1.816e-06	53.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria,1WC7A@1268|Micrococcaceae	201174|Actinobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_647564_7	1132441.KI519454_gene1680	7.543e-66	231.0	COG0406@1|root,COG0406@2|Bacteria,2GJYU@201174|Actinobacteria,1W982@1268|Micrococcaceae	201174|Actinobacteria	G	Phosphoglycerate mutase family	gpmB	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237	3.1.3.85,5.4.2.11	ko:K01834,ko:K22306	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
TLS2_k127_647564_9	1236902.ANAS01000023_gene3305	1.561e-52	193.0	COG0799@1|root,COG0799@2|Bacteria,2IKZ3@201174|Actinobacteria,4EJAE@85012|Streptosporangiales	201174|Actinobacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
TLS2_k127_647564_5	443255.SCLAV_1750	4.539e-100	329.0	COG1057@1|root,COG1057@2|Bacteria,2GMFZ@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_647564_2	1120950.KB892766_gene5104	2.531e-179	573.0	COG0014@1|root,COG0014@2|Bacteria,2GISA@201174|Actinobacteria,4DNEG@85009|Propionibacteriales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2427c	Aldedh
TLS2_k127_647564_10	1306174.JODP01000032_gene4025	3.871e-51	199.0	COG0739@1|root,COG0739@2|Bacteria,2GXEC@201174|Actinobacteria	201174|Actinobacteria	M	peptidase	pdc2	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
TLS2_k127_647564_12	591157.SSLG_01805	1.441e-37	144.0	2E4W3@1|root,32ZQA@2|Bacteria,2II8G@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_647564_3	1123320.KB889629_gene7901	1.33e-161	518.0	COG0263@1|root,COG0263@2|Bacteria,2GM8U@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
TLS2_k127_647564_1	1048339.KB913029_gene4850	2.736e-208	656.0	COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,4ES3D@85013|Frankiales	201174|Actinobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
TLS2_k127_647564_11	1033730.CAHG01000015_gene831	1.189e-39	154.0	COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4DRNG@85009|Propionibacteriales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
TLS2_k127_647564_13	1122997.AUDD01000009_gene257	4.209e-36	141.0	COG0261@1|root,COG0261@2|Bacteria,2IQ9A@201174|Actinobacteria,4DRJ6@85009|Propionibacteriales	201174|Actinobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
TLS2_k127_647564_0	1463917.JODC01000006_gene8145	9.731e-257	818.0	COG1530@1|root,COG1530@2|Bacteria,2GMM5@201174|Actinobacteria	201174|Actinobacteria	J	ribonuclease Rne Rng family	rne	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	IF2_N,RNase_E_G,S1
TLS2_k127_6480142_0	298653.Franean1_5233	1.182e-274	864.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4EU1V@85013|Frankiales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994,ko:K20470	-	-	-	-	ko00000,ko02000	2.A.6.5.6	-	-	MMPL
TLS2_k127_6480142_9	1120950.KB892769_gene5386	5.652e-53	188.0	2AFXT@1|root,3161G@2|Bacteria,2IKPZ@201174|Actinobacteria,4DR0E@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF2469)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2469
TLS2_k127_6480142_5	1298863.AUEP01000002_gene1392	5.955e-90	307.0	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,4DPWD@85009|Propionibacteriales	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
TLS2_k127_6480142_6	680198.SCAB_26131	1.534e-66	236.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria	201174|Actinobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS2_k127_6480142_8	351607.Acel_1557	5.377e-57	202.0	COG0335@1|root,COG0335@2|Bacteria,2IHRT@201174|Actinobacteria,4ESVQ@85013|Frankiales	201174|Actinobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
TLS2_k127_6480142_4	1120950.KB892769_gene5390	2.631e-111	365.0	COG0336@1|root,COG0336@2|Bacteria,2GJ1G@201174|Actinobacteria,4DNVI@85009|Propionibacteriales	201174|Actinobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,tRNA_m1G_MT
TLS2_k127_6480142_7	436229.JOEH01000033_gene3585	7.683e-59	218.0	COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,2NEBS@228398|Streptacidiphilus	201174|Actinobacteria	J	RimM N-terminal domain	rimM	GO:0008150,GO:0040007	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
TLS2_k127_6480142_11	397278.JOJN01000001_gene2700	1.112e-27	123.0	COG1837@1|root,COG1837@2|Bacteria,2IQ4C@201174|Actinobacteria,4DRVC@85009|Propionibacteriales	201174|Actinobacteria	S	KH domain	-	GO:0008150,GO:0040007	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
TLS2_k127_6480142_10	471852.Tcur_3423	9.467e-53	201.0	COG0228@1|root,COG0228@2|Bacteria,2IKU0@201174|Actinobacteria,4EJRE@85012|Streptosporangiales	201174|Actinobacteria	J	Ribosomal protein S16	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TLS2_k127_6480142_3	566461.SSFG_05510	1.651e-149	481.0	COG1228@1|root,COG1228@2|Bacteria,2GKRZ@201174|Actinobacteria	201174|Actinobacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_6480142_2	1298863.AUEP01000002_gene1382	6.125e-239	760.0	COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria,4DNUI@85009|Propionibacteriales	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TLS2_k127_6480142_1	235985.BBPN01000031_gene2120	1.091e-246	783.0	COG2844@1|root,COG2844@2|Bacteria,2GMKT@201174|Actinobacteria,2NENB@228398|Streptacidiphilus	201174|Actinobacteria	O	GlnD PII-uridylyltransferase	glnD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
TLS2_k127_6534180_23	397278.JOJN01000017_gene2552	6.338e-12	65.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4DNEV@85009|Propionibacteriales	201174|Actinobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_6534180_3	1122609.AUGT01000002_gene3995	2.328e-223	700.0	COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,4DMZJ@85009|Propionibacteriales	201174|Actinobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS2_k127_6534180_21	479435.Kfla_4343	6.939e-32	141.0	COG0505@1|root,COG0505@2|Bacteria,2GM9I@201174|Actinobacteria	201174|Actinobacteria	EF	Belongs to the CarA family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6534180_6	66429.JOFL01000005_gene3752	1.123e-173	569.0	COG0505@1|root,COG0505@2|Bacteria,2GKFA@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
TLS2_k127_6534180_0	1120950.KB892708_gene4316	0.0	1758.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4DNSQ@85009|Propionibacteriales	201174|Actinobacteria	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS2_k127_6534180_7	1120950.KB892768_gene5345	7.318e-126	442.0	COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4DP48@85009|Propionibacteriales	201174|Actinobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.3.5.2,1.3.98.1	ko:K00226,ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01867,R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TLS2_k127_6534180_9	1906.SFRA_30755	6.467e-103	361.0	COG0284@1|root,COG0284@2|Bacteria,2GKWK@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
TLS2_k127_6534180_18	1211815.CBYP010000029_gene1241	2.107e-39	154.0	COG0589@1|root,COG0589@2|Bacteria,2IP0V@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_6534180_16	67373.JOBF01000001_gene6107	4.76e-46	168.0	COG0099@1|root,COG0099@2|Bacteria,2IKPU@201174|Actinobacteria	201174|Actinobacteria	J	integration host factor	mihF	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6534180_13	269800.Tfu_1062	1.234e-74	258.0	COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria,4EGNM@85012|Streptosporangiales	201174|Actinobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
TLS2_k127_6534180_19	1298863.AUEP01000012_gene3757	3.081e-36	148.0	COG1758@1|root,COG1758@2|Bacteria,2IQHU@201174|Actinobacteria,4DRNP@85009|Propionibacteriales	201174|Actinobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
TLS2_k127_6534180_5	43759.JNWK01000015_gene33	3.328e-177	564.0	COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TLS2_k127_6534180_4	1123320.KB889665_gene1445	2.219e-204	661.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
TLS2_k127_6534180_2	1120950.KB892708_gene4330	3.429e-232	739.0	COG1198@1|root,COG1198@2|Bacteria,2GKES@201174|Actinobacteria,4DNMW@85009|Propionibacteriales	201174|Actinobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
TLS2_k127_6534180_17	298655.KI912266_gene1566	1.789e-45	177.0	COG1503@1|root,COG1503@2|Bacteria,2IFQH@201174|Actinobacteria,4ET50@85013|Frankiales	201174|Actinobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6534180_15	1122611.KB903940_gene1865	1.953e-48	192.0	COG0619@1|root,COG0619@2|Bacteria,2IQMQ@201174|Actinobacteria,4EJZN@85012|Streptosporangiales	201174|Actinobacteria	P	Cobalt transport protein	bioN	-	-	ko:K16783	ko02010,map02010	M00581	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25.1	-	-	CbiQ
TLS2_k127_6534180_11	1120934.KB894407_gene5096	3.814e-87	300.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4DZKU@85010|Pseudonocardiales	201174|Actinobacteria	P	ABC-type cobalt transport system, ATPase component	bioM	-	-	ko:K16784	ko02010,map02010	M00581	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25.1	-	-	ABC_tran
TLS2_k127_6534180_8	1120950.KB892707_gene4673	3.587e-124	410.0	COG0183@1|root,COG0183@2|Bacteria,2GM29@201174|Actinobacteria,4DTNT@85009|Propionibacteriales	201174|Actinobacteria	I	Thiolase, C-terminal domain	yhfS	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_6534180_12	479432.Sros_5455	8.623e-80	282.0	COG0318@1|root,COG0318@2|Bacteria,2I908@201174|Actinobacteria,4EJXH@85012|Streptosporangiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS2_k127_6534180_14	1120950.KB892707_gene4675	1.097e-60	218.0	COG1268@1|root,COG1268@2|Bacteria,2GJ53@201174|Actinobacteria,4DSED@85009|Propionibacteriales	201174|Actinobacteria	S	BioY family	bioY	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
TLS2_k127_6534180_10	68223.JNZY01000029_gene44	2.269e-97	328.0	COG2321@1|root,COG2321@2|Bacteria,2H3UT@201174|Actinobacteria	201174|Actinobacteria	S	Neutral zinc metallopeptidase	ypfJ	GO:0005575,GO:0005576	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
TLS2_k127_6534180_1	1122622.ATWJ01000010_gene1331	3.093e-255	802.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria,4FESG@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter	ybiT	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn,DLIC
TLS2_k127_6534180_22	43354.JOIJ01000002_gene4322	7.65e-24	108.0	2E4I7@1|root,32ZDA@2|Bacteria,2IQBB@201174|Actinobacteria,4E5H2@85010|Pseudonocardiales	201174|Actinobacteria	S	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6534180_20	1449353.JQMQ01000005_gene1499	1.468e-33	138.0	COG1024@1|root,COG1024@2|Bacteria,2GKC4@201174|Actinobacteria,2NFFV@228398|Streptacidiphilus	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	echA	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_6543000_1	1122939.ATUD01000013_gene821	2.714e-83	302.0	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria,4CPR1@84995|Rubrobacteria	84995|Rubrobacteria	EK	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
TLS2_k127_6543000_2	1120950.KB892763_gene5527	1.552e-77	265.0	COG2364@1|root,COG2364@2|Bacteria,2GKA1@201174|Actinobacteria,4DQWJ@85009|Propionibacteriales	201174|Actinobacteria	S	membrane	-	-	-	ko:K07149	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_6543000_0	469371.Tbis_3117	3.038e-145	475.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4DX61@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Cys Met metabolism	metB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1079	Cys_Met_Meta_PP
TLS2_k127_656080_4	1120950.KB892764_gene5643	2.831e-102	353.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,4DP2Z@85009|Propionibacteriales	201174|Actinobacteria	NU	Type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_656080_3	1120950.KB892764_gene5642	1.776e-110	366.0	COG4965@1|root,COG4965@2|Bacteria,2I3KW@201174|Actinobacteria,4DNMD@85009|Propionibacteriales	201174|Actinobacteria	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_656080_2	1120950.KB892764_gene5641	7.719e-207	653.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4DN91@85009|Propionibacteriales	201174|Actinobacteria	U	Type II/IV secretion system protein	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS2_k127_656080_0	1211815.CBYP010000021_gene3259	0.0	1096.0	COG1674@1|root,COG1674@2|Bacteria,2GJBR@201174|Actinobacteria,4ES0S@85013|Frankiales	201174|Actinobacteria	D	PFAM cell divisionFtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE,Yop-YscD_cpl
TLS2_k127_656080_5	1283283.ATXA01000002_gene2673	3.374e-20	96.0	COG4842@1|root,COG4842@2|Bacteria,2HU2S@201174|Actinobacteria,4EWPE@85013|Frankiales	201174|Actinobacteria	S	PE family	-	-	-	-	-	-	-	-	-	-	-	-	WXG100
TLS2_k127_656080_1	1120950.KB892764_gene5640	1.134e-212	675.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4DNQX@85009|Propionibacteriales	201174|Actinobacteria	E	Bacterial NAD-glutamate dehydrogenase	gdh	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
TLS2_k127_6569455_2	44060.JODL01000002_gene2377	1.378e-224	702.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria	201174|Actinobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
TLS2_k127_6569455_6	1237500.ANBA01000033_gene4526	1.111e-46	180.0	COG0741@1|root,COG0741@2|Bacteria,2GM11@201174|Actinobacteria,4EJ12@85012|Streptosporangiales	201174|Actinobacteria	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TLS2_k127_6569455_4	1380346.JNIH01000006_gene3483	4.278e-122	397.0	COG1595@1|root,COG1595@2|Bacteria,2GKBH@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
TLS2_k127_6569455_3	1172179.AUKV01000007_gene2997	2.527e-122	401.0	COG0451@1|root,COG0451@2|Bacteria,2I2SW@201174|Actinobacteria	201174|Actinobacteria	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_6569455_7	526225.Gobs_0207	3.124e-36	149.0	COG0474@1|root,COG0474@2|Bacteria	2|Bacteria	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	cybH	-	-	-	-	-	-	-	-	-	-	-	DUF4153,Ni_hydr_CYTB
TLS2_k127_6569455_1	1120950.KB892823_gene569	3.874e-234	732.0	COG1875@1|root,COG1875@2|Bacteria,2GK8U@201174|Actinobacteria,4DNRD@85009|Propionibacteriales	201174|Actinobacteria	T	phosphate starvation-inducible protein PhoH	phoH2	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
TLS2_k127_6569455_0	1122611.KB903940_gene2055	8.085e-261	838.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4EGTA@85012|Streptosporangiales	201174|Actinobacteria	P	Cation transporter/ATPase, N-terminus	ctpF	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.8	ko:K01537,ko:K12953	-	-	-	-	ko00000,ko01000	3.A.3,3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS2_k127_6569455_5	110319.CF8_0781	1.854e-69	236.0	COG0020@1|root,COG0020@2|Bacteria,2GJCP@201174|Actinobacteria,4DPJB@85009|Propionibacteriales	201174|Actinobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS1	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS2_k127_6572582_8	1349820.M707_00290	7.302e-12	70.0	COG1612@1|root,COG1612@2|Bacteria,2GJQX@201174|Actinobacteria,1W7TW@1268|Micrococcaceae	201174|Actinobacteria	O	cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
TLS2_k127_6572582_6	590998.Celf_3363	1.185e-60	219.0	COG5343@1|root,COG5343@2|Bacteria,2IM7X@201174|Actinobacteria,4F2HP@85016|Cellulomonadaceae	201174|Actinobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
TLS2_k127_6572582_5	590998.Celf_3362	3.451e-67	238.0	COG1595@1|root,COG1595@2|Bacteria,2IKQ7@201174|Actinobacteria,4F2I1@85016|Cellulomonadaceae	201174|Actinobacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	litS	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_6572582_7	590998.Celf_3361	4.053e-42	164.0	COG3764@1|root,COG3764@2|Bacteria,2IR30@201174|Actinobacteria,4F2MS@85016|Cellulomonadaceae	201174|Actinobacteria	M	PFAM peptidase C60 sortase A and B	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
TLS2_k127_6572582_2	590998.Celf_3360	1.277e-104	349.0	arCOG06227@1|root,2ZCRG@2|Bacteria,2I96P@201174|Actinobacteria,4F271@85016|Cellulomonadaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
TLS2_k127_6572582_4	591167.Sfla_4895	1.038e-82	296.0	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
TLS2_k127_6572582_0	1210045.ALNP01000010_gene1164	3.001e-121	400.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	drrA_2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6572582_3	1120950.KB892707_gene4649	2.249e-87	295.0	COG2345@1|root,COG2345@2|Bacteria,2GN8W@201174|Actinobacteria,4DQCB@85009|Propionibacteriales	201174|Actinobacteria	K	Transcriptional regulator	sufR	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20,HTH_24,HTH_5,MarR_2
TLS2_k127_6572582_1	1223523.H340_25647	1.143e-117	393.0	COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria	201174|Actinobacteria	O	assembly protein sufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TLS2_k127_6576249_2	105422.BBPM01000075_gene151	7.734e-109	354.0	COG0448@1|root,COG0448@2|Bacteria,2I2EF@201174|Actinobacteria,2NGNI@228398|Streptacidiphilus	201174|Actinobacteria	G	Nucleotidyl transferase	glgC	GO:0000271,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901576	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
TLS2_k127_6576249_0	479435.Kfla_5498	2.266e-171	545.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria,4DN2C@85009|Propionibacteriales	201174|Actinobacteria	G	Glycosyl transferases group 1	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100	-	R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_6576249_1	590998.Celf_2884	1.003e-133	444.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4F0PP@85016|Cellulomonadaceae	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS2_k127_6576249_5	100226.SCO5145	1.393e-21	108.0	2E39N@1|root,32Y97@2|Bacteria,2GQFF@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3117
TLS2_k127_6576249_4	2002.JOEQ01000007_gene1895	1.147e-86	316.0	COG3327@1|root,COG3327@2|Bacteria,2GNME@201174|Actinobacteria,4EHQ8@85012|Streptosporangiales	201174|Actinobacteria	K	PaaX-like protein	paaX	-	-	ko:K02616	-	-	-	-	ko00000,ko03000	-	-	-	PaaX,PaaX_C
TLS2_k127_6576249_3	479435.Kfla_5504	6.396e-104	347.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4DNXW@85009|Propionibacteriales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	chcB	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS2_k127_6581053_1	1123320.KB889677_gene2740	1.3e-216	683.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria	201174|Actinobacteria	C	malic enzyme	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
TLS2_k127_6581053_5	1206731.BAGB01000171_gene4693	2.993e-89	310.0	COG0524@1|root,COG0524@2|Bacteria,2GYHF@201174|Actinobacteria,4FW3P@85025|Nocardiaceae	201174|Actinobacteria	G	pfkB family carbohydrate kinase	pfkB	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS2_k127_6581053_11	1122611.KB903940_gene1755	1.861e-52	196.0	COG1975@1|root,COG1975@2|Bacteria,2IK3Z@201174|Actinobacteria,4EP84@85012|Streptosporangiales	201174|Actinobacteria	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C
TLS2_k127_6581053_10	68199.JNZO01000012_gene3399	1.611e-52	192.0	COG2085@1|root,COG2085@2|Bacteria,2GMN3@201174|Actinobacteria	201174|Actinobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
TLS2_k127_6581053_15	1120948.KB903229_gene5047	5.716e-16	91.0	COG1295@1|root,COG1295@2|Bacteria,2HMYQ@201174|Actinobacteria,4E4Y5@85010|Pseudonocardiales	201174|Actinobacteria	S	Virulence factor BrkB	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
TLS2_k127_6581053_3	1380356.JNIK01000013_gene4263	8.145e-152	498.0	COG1524@1|root,2Z9VM@2|Bacteria,2GWA2@201174|Actinobacteria,4EUKJ@85013|Frankiales	201174|Actinobacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6581053_9	1907.SGLAU_03255	1.183e-64	230.0	COG1670@1|root,COG1670@2|Bacteria,2II7U@201174|Actinobacteria	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_6581053_13	467200.ACFA01000161_gene4695	3.419e-26	123.0	COG0739@1|root,COG0741@1|root,COG0739@2|Bacteria,COG0741@2|Bacteria	2|Bacteria	M	lytic transglycosylase activity	pdc2	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23,SLT
TLS2_k127_6581053_2	561175.KB894094_gene1626	5.77e-214	704.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria,4EIEI@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Trans_reg_C
TLS2_k127_6581053_6	1312954.KI914848_gene2071	2.866e-79	276.0	COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria	201174|Actinobacteria	IQ	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
TLS2_k127_6581053_16	365528.KB891211_gene2379	1.716e-06	55.0	COG0582@1|root,COG0582@2|Bacteria,2IHIW@201174|Actinobacteria,4EURT@85013|Frankiales	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
TLS2_k127_6581053_4	1306990.BARG01000088_gene8697	3.29e-148	499.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2GIVU@201174|Actinobacteria	201174|Actinobacteria	T	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,PAS_3,PAS_4,SpoIIE
TLS2_k127_6581053_0	882083.SacmaDRAFT_1436	1.291e-299	931.0	COG1960@1|root,COG1960@2|Bacteria,2GKK9@201174|Actinobacteria,4DZH1@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	fadE10	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
TLS2_k127_6581053_12	1032480.MLP_24830	1.395e-29	124.0	COG1595@1|root,COG1595@2|Bacteria,2HG34@201174|Actinobacteria,4DWA5@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6581053_8	397278.JOJN01000007_gene3147	5.359e-67	247.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria,4DQDM@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
TLS2_k127_6581053_7	351607.Acel_1728	1.295e-71	245.0	COG0691@1|root,COG0691@2|Bacteria,2GJX1@201174|Actinobacteria,4ESH9@85013|Frankiales	201174|Actinobacteria	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
TLS2_k127_6581053_14	585531.HMPREF0063_12022	1.827e-20	91.0	COG0739@1|root,COG0739@2|Bacteria,2GXEC@201174|Actinobacteria,4DPWU@85009|Propionibacteriales	201174|Actinobacteria	M	Peptidase family M23	pdc2	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
TLS2_k127_6582963_6	1214242.B446_09270	1.466e-74	264.0	COG0457@1|root,COG0457@2|Bacteria,2GKX5@201174|Actinobacteria	201174|Actinobacteria	A	Belongs to the DEAD box helicase family	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
TLS2_k127_6582963_8	1122609.AUGT01000002_gene4060	2.29e-25	115.0	COG0629@1|root,COG0629@2|Bacteria,2GRPQ@201174|Actinobacteria,4DSF0@85009|Propionibacteriales	201174|Actinobacteria	L	Single-strand binding protein family	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_6582963_3	1206101.AZXC01000028_gene4923	3.125e-108	368.0	COG4198@1|root,COG4198@2|Bacteria,2GJFV@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
TLS2_k127_6582963_5	1048339.KB913029_gene3276	5.559e-104	371.0	COG0647@1|root,COG0647@2|Bacteria,2GK7V@201174|Actinobacteria,4ESEC@85013|Frankiales	201174|Actinobacteria	G	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
TLS2_k127_6582963_9	1122138.AQUZ01000006_gene1463	7.956e-19	93.0	COG3937@1|root,COG3937@2|Bacteria,2I1FP@201174|Actinobacteria,4DVQJ@85009|Propionibacteriales	201174|Actinobacteria	S	granule-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
TLS2_k127_6582963_4	1123320.KB889589_gene4237	5.998e-106	352.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria	201174|Actinobacteria	J	Ribosomal RNA methyltransferase RrmJ FtsJ	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
TLS2_k127_6582963_2	1120950.KB892767_gene5183	1.13e-122	406.0	COG0061@1|root,COG0061@2|Bacteria,2GKM2@201174|Actinobacteria,4DPDG@85009|Propionibacteriales	201174|Actinobacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006797,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
TLS2_k127_6582963_0	1123320.KB889589_gene4239	4.16e-214	682.0	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria	201174|Actinobacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
TLS2_k127_6582963_1	1120950.KB892767_gene5181	1.211e-174	556.0	COG4825@1|root,COG4825@2|Bacteria,2GPAA@201174|Actinobacteria,4DNDI@85009|Propionibacteriales	201174|Actinobacteria	S	Thiamine pyrophosphokinase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TPPK_C
TLS2_k127_6582963_7	1120950.KB892767_gene5180	7.845e-54	203.0	2D1T0@1|root,32TBA@2|Bacteria,2I8E5@201174|Actinobacteria,4DRW3@85009|Propionibacteriales	201174|Actinobacteria	S	Copper transport outer membrane protein, MctB	mctB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0008150,GO:0009279,GO:0015267,GO:0015288,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0044425,GO:0044462,GO:0044464,GO:0046930,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796	-	-	-	-	-	-	-	-	-	-	MctB
TLS2_k127_6585402_0	935839.JAGJ01000005_gene2692	8.421e-207	651.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4F3N9@85017|Promicromonosporaceae	201174|Actinobacteria	E	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_6585402_8	1449353.JQMQ01000005_gene5771	1.077e-16	86.0	2EGVE@1|root,33AMN@2|Bacteria,2GQWM@201174|Actinobacteria,2NK0U@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6585402_7	66869.JNXG01000017_gene4935	3.485e-18	94.0	2ECBY@1|root,336AB@2|Bacteria,2GXKR@201174|Actinobacteria,419VG@629295|Streptomyces griseus group	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6585402_4	1463895.JODA01000018_gene5960	2.586e-61	237.0	COG0507@1|root,COG0507@2|Bacteria,2GIX1@201174|Actinobacteria	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	-	-	3.1.11.5	ko:K01144,ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,UvrD_C_2
TLS2_k127_6585402_2	1120950.KB892708_gene4395	6.198e-152	487.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4DPF5@85009|Propionibacteriales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_6585402_1	211114.JOEF01000035_gene1459	1.354e-158	507.0	COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,4DXE3@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_6585402_3	110319.CF8_1947	2.385e-127	412.0	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,4DN4Z@85009|Propionibacteriales	201174|Actinobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
TLS2_k127_6585402_6	1048339.KB913029_gene5047	2.645e-38	164.0	COG0739@1|root,COG0739@2|Bacteria,2GXEC@201174|Actinobacteria,4EW3Z@85013|Frankiales	201174|Actinobacteria	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	envC	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
TLS2_k127_6585402_5	1123320.KB889677_gene2738	2.257e-39	160.0	COG4942@1|root,COG4942@2|Bacteria,2GP1Y@201174|Actinobacteria	201174|Actinobacteria	D	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
TLS2_k127_6604450_6	2002.JOEQ01000032_gene1736	1.522e-06	55.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4EJD9@85012|Streptosporangiales	201174|Actinobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_6604450_4	1123023.JIAI01000014_gene3701	6.824e-40	158.0	COG0748@1|root,COG0748@2|Bacteria,2IFHD@201174|Actinobacteria,4E6MR@85010|Pseudonocardiales	201174|Actinobacteria	P	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_6604450_0	479432.Sros_5187	4.512e-140	462.0	COG0520@1|root,COG0520@2|Bacteria,2H9MG@201174|Actinobacteria,4EHWB@85012|Streptosporangiales	201174|Actinobacteria	E	Aminotransferase class-V	egtE	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_6604450_3	1123024.AUII01000009_gene1954	1.895e-83	284.0	2A651@1|root,30UXH@2|Bacteria,2IERM@201174|Actinobacteria,4EBDG@85010|Pseudonocardiales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS2_k127_6604450_2	222534.KB893750_gene4367	5.218e-92	330.0	COG0426@1|root,COG0426@2|Bacteria,2GJT6@201174|Actinobacteria,4EWE7@85013|Frankiales	201174|Actinobacteria	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
TLS2_k127_6604450_1	222534.KB893750_gene4365	2.943e-132	434.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_6605790_1	1122138.AQUZ01000037_gene5590	7.6e-70	243.0	COG1846@1|root,COG1940@1|root,COG1846@2|Bacteria,COG1940@2|Bacteria,2GJIE@201174|Actinobacteria,4DPBY@85009|Propionibacteriales	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,MarR_2,ROK
TLS2_k127_6605790_0	446468.Ndas_1386	2.864e-193	613.0	COG1070@1|root,COG1070@2|Bacteria,2GJDZ@201174|Actinobacteria,4EFJC@85012|Streptosporangiales	201174|Actinobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS2_k127_6606533_11	2074.JNYD01000015_gene4574	5.303e-09	58.0	COG4221@1|root,COG4221@2|Bacteria,2IBSS@201174|Actinobacteria,4DZGG@85010|Pseudonocardiales	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_6606533_5	1463934.JOCF01000073_gene5825	3.411e-120	410.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria	201174|Actinobacteria	S	unusual protein kinase	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
TLS2_k127_6606533_9	298655.KI912266_gene996	2.308e-28	119.0	COG2146@1|root,COG2146@2|Bacteria,2IKSY@201174|Actinobacteria,4ETHF@85013|Frankiales	201174|Actinobacteria	P	PFAM Rieske 2Fe-2S	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	Rieske
TLS2_k127_6606533_8	1380354.JIAN01000005_gene1272	1.088e-65	229.0	2B3JS@1|root,31W90@2|Bacteria,2GP1G@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6606533_6	457425.XNR_5781	1.424e-75	260.0	COG0110@1|root,COG0110@2|Bacteria,2GNUB@201174|Actinobacteria	201174|Actinobacteria	M	Acetyltransferase (isoleucine patch	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2,Mac
TLS2_k127_6606533_10	1211815.CBYP010000006_gene275	6.375e-16	86.0	COG1403@1|root,COG1403@2|Bacteria,2IRX4@201174|Actinobacteria,4EW07@85013|Frankiales	201174|Actinobacteria	V	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
TLS2_k127_6606533_2	1380356.JNIK01000016_gene3721	4.732e-130	423.0	COG5285@1|root,COG5285@2|Bacteria,2IF9U@201174|Actinobacteria	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS2_k127_6606533_4	1123023.JIAI01000007_gene1818	1.851e-124	420.0	COG3057@1|root,COG3057@2|Bacteria,2I60V@201174|Actinobacteria	201174|Actinobacteria	L	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6606533_1	526225.Gobs_3643	4.792e-145	471.0	COG0016@1|root,COG0072@1|root,COG0016@2|Bacteria,COG0072@2|Bacteria,2GN8Y@201174|Actinobacteria	201174|Actinobacteria	J	Phenylalanyl-tRNA synthetase	-	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	FDX-ACB,tRNA-synt_2d
TLS2_k127_6606533_3	928724.SacglDRAFT_00891	6.662e-129	420.0	COG0389@1|root,COG0389@2|Bacteria,2GKHC@201174|Actinobacteria,4DZPZ@85010|Pseudonocardiales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
TLS2_k127_6606533_0	1123024.AUII01000016_gene1311	0.0	1252.0	COG1330@1|root,COG1330@2|Bacteria,2GNVB@201174|Actinobacteria,4E8FA@85010|Pseudonocardiales	201174|Actinobacteria	L	Exodeoxyribonuclease V, gamma subunit	recC	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
TLS2_k127_6606533_7	1313172.YM304_04250	4.556e-75	263.0	COG3832@1|root,COG3832@2|Bacteria,2IQUJ@201174|Actinobacteria	201174|Actinobacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_6624213_0	2002.JOEQ01000030_gene2092	0.0	1161.0	COG1391@1|root,COG1391@2|Bacteria,2GJ91@201174|Actinobacteria,4EFGN@85012|Streptosporangiales	201174|Actinobacteria	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
TLS2_k127_6624213_1	471852.Tcur_3608	0.0002177	44.0	COG0616@1|root,COG0616@2|Bacteria,2HQDG@201174|Actinobacteria,4EHD6@85012|Streptosporangiales	201174|Actinobacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773,ko:K04774	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TLS2_k127_6624966_11	1429046.RR21198_4340	3.518e-21	93.0	COG2909@1|root,COG2909@2|Bacteria,2HHNU@201174|Actinobacteria,4FZFM@85025|Nocardiaceae	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
TLS2_k127_6624966_2	1123024.AUII01000015_gene3750	1.034e-158	513.0	COG0654@1|root,COG0654@2|Bacteria,2GK7I@201174|Actinobacteria,4DXC9@85010|Pseudonocardiales	201174|Actinobacteria	CH	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_binding_3,FAD_oxidored
TLS2_k127_6624966_5	1869.MB27_08290	2.647e-103	346.0	COG0428@1|root,COG0428@2|Bacteria,2GISJ@201174|Actinobacteria,4DDTQ@85008|Micromonosporales	201174|Actinobacteria	P	zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
TLS2_k127_6624966_10	649831.L083_6279	3.852e-43	168.0	COG3173@1|root,COG3173@2|Bacteria,2HUA6@201174|Actinobacteria,4DDGZ@85008|Micromonosporales	201174|Actinobacteria	S	Phosphotransferase enzyme family	aph	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_6624966_4	350058.Mvan_1138	1.45e-127	420.0	COG3012@1|root,COG3012@2|Bacteria,2GMVI@201174|Actinobacteria,23944@1762|Mycobacteriaceae	201174|Actinobacteria	S	Plasmid pRiA4b ORF-3-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
TLS2_k127_6624966_13	350058.Mvan_1138	2.947e-12	69.0	COG3012@1|root,COG3012@2|Bacteria,2GMVI@201174|Actinobacteria,23944@1762|Mycobacteriaceae	201174|Actinobacteria	S	Plasmid pRiA4b ORF-3-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
TLS2_k127_6624966_9	313589.JNB_14963	2.16e-61	213.0	COG4334@1|root,COG4334@2|Bacteria,2HMQX@201174|Actinobacteria,4FJT8@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2255
TLS2_k127_6624966_1	1121924.ATWH01000008_gene765	4.393e-190	612.0	COG4585@1|root,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria,4FP8H@85023|Microbacteriaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_6624966_7	1121924.ATWH01000008_gene764	9.9e-86	297.0	COG2197@1|root,COG2197@2|Bacteria,2GM61@201174|Actinobacteria,4FR0W@85023|Microbacteriaceae	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_6624966_8	1385519.N801_01225	8.385e-85	283.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	yokL3	-	2.3.1.57	ko:K00657,ko:K07023	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_3
TLS2_k127_6624966_14	1136417.AZWE01000001_gene3761	1.342e-11	74.0	2E2CD@1|root,32XHD@2|Bacteria,2IESQ@201174|Actinobacteria,4DBC9@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
TLS2_k127_6624966_6	1121946.AUAX01000008_gene7363	5.897e-89	309.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4D9SZ@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6624966_3	1312954.KI914851_gene1830	4.144e-144	502.0	COG2267@1|root,COG2267@2|Bacteria,2I9JC@201174|Actinobacteria	201174|Actinobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
TLS2_k127_6624966_0	1032480.MLP_04290	0.0	1015.0	COG2015@1|root,COG2015@2|Bacteria,2GK38@201174|Actinobacteria,4DT13@85009|Propionibacteriales	201174|Actinobacteria	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
TLS2_k127_6624966_12	1123258.AQXZ01000018_gene887	1.812e-18	86.0	COG2267@1|root,COG2267@2|Bacteria,2GUBM@201174|Actinobacteria,4G9JT@85025|Nocardiaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	phaB	-	3.1.1.76	ko:K22250	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_6637128_2	710696.Intca_0183	4.248e-181	583.0	COG4222@1|root,COG4222@2|Bacteria,2GJN8@201174|Actinobacteria,4FF9Q@85021|Intrasporangiaceae	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_6637128_5	1463855.JOHV01000027_gene1270	3.767e-64	228.0	COG3885@1|root,COG3885@2|Bacteria,2GN3T@201174|Actinobacteria	201174|Actinobacteria	S	ferrous iron binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6637128_3	479435.Kfla_4721	4.973e-121	395.0	COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria,4DP56@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
TLS2_k127_6637128_0	526225.Gobs_2332	2.788e-225	717.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria	201174|Actinobacteria	E	gamma-glutamyltransferase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_6637128_4	44060.JODL01000012_gene3480	1.436e-93	322.0	COG0253@1|root,COG0253@2|Bacteria,2GKUD@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
TLS2_k127_6637128_1	1033730.CAHG01000013_gene1439	1.346e-214	677.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4DNPS@85009|Propionibacteriales	201174|Actinobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TLS2_k127_6657162_0	1179773.BN6_14930	1.122e-192	610.0	COG1372@1|root,COG1702@1|root,COG1372@2|Bacteria,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria,4DY9G@85010|Pseudonocardiales	201174|Actinobacteria	T	Phosphate starvation-inducible protein PhoH	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
TLS2_k127_6657162_3	1048339.KB913029_gene4798	4.841e-60	216.0	COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4ESS6@85013|Frankiales	201174|Actinobacteria	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
TLS2_k127_6657162_1	1120950.KB892739_gene3991	1.577e-171	556.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4DNND@85009|Propionibacteriales	201174|Actinobacteria	S	Transporter associated domain	corC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_6657162_5	1463887.KL589981_gene6035	1.042e-34	136.0	COG0295@1|root,COG0295@2|Bacteria,2IM42@201174|Actinobacteria	201174|Actinobacteria	F	cytidine deaminase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6657162_4	1283299.AUKG01000001_gene2045	2.952e-38	156.0	COG0697@1|root,COG0697@2|Bacteria,2GMPJ@201174|Actinobacteria,4CQ3D@84995|Rubrobacteria	84995|Rubrobacteria	EG	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
TLS2_k127_6657162_2	67257.JODR01000023_gene5323	4.288e-151	492.0	COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria	201174|Actinobacteria	M	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
TLS2_k127_6661971_0	1089455.MOPEL_132_00380	0.0	1422.0	COG0110@1|root,COG1020@1|root,COG0110@2|Bacteria,COG1020@2|Bacteria,2I8TI@201174|Actinobacteria,4F7NP@85018|Dermatophilaceae	201174|Actinobacteria	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Hexapep,Hexapep_2,PP-binding
TLS2_k127_666834_0	1120950.KB892764_gene5608	2.157e-144	470.0	COG0455@1|root,COG0455@2|Bacteria,2IARP@201174|Actinobacteria,4DQ9Q@85009|Propionibacteriales	201174|Actinobacteria	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
TLS2_k127_666834_1	1146883.BLASA_4092	1.828e-26	121.0	2EMPV@1|root,33FCA@2|Bacteria,2I5I4@201174|Actinobacteria,4ETCU@85013|Frankiales	201174|Actinobacteria	S	SAF	-	-	-	-	-	-	-	-	-	-	-	-	ChapFlgA,SAF
TLS2_k127_666834_2	1120950.KB892764_gene5606	1.011e-08	56.0	COG3311@1|root,COG3311@2|Bacteria,2GR98@201174|Actinobacteria,4DS1Q@85009|Propionibacteriales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
TLS2_k127_6669881_1	1313172.YM304_03090	5.305e-193	623.0	COG0737@1|root,COG0737@2|Bacteria,2I7X6@201174|Actinobacteria,4CP5J@84992|Acidimicrobiia	2|Bacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
TLS2_k127_6669881_2	479432.Sros_0893	1.184e-114	378.0	COG0454@1|root,COG0454@2|Bacteria,COG0456@2|Bacteria,2GM35@201174|Actinobacteria,4EHNC@85012|Streptosporangiales	201174|Actinobacteria	K	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol	mshD	GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
TLS2_k127_6669881_0	1120950.KB892777_gene739	0.0	1035.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria,4DNIH@85009|Propionibacteriales	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
TLS2_k127_6669881_3	1304865.JAGF01000001_gene2382	1.067e-98	342.0	COG5607@1|root,COG5607@2|Bacteria,2GJZH@201174|Actinobacteria	201174|Actinobacteria	S	CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
TLS2_k127_6698931_0	446466.Cfla_1360	7.971e-211	676.0	COG1080@1|root,COG1080@2|Bacteria,2GIZZ@201174|Actinobacteria,4F207@85016|Cellulomonadaceae	201174|Actinobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
TLS2_k127_6698931_3	1380354.JIAN01000005_gene2466	1.837e-193	625.0	COG1263@1|root,COG1263@2|Bacteria,2GKPM@201174|Actinobacteria,4F28N@85016|Cellulomonadaceae	201174|Actinobacteria	G	Phosphotransferase system, EIIC	gamP	-	-	ko:K02804	ko00520,ko02060,map00520,map02060	M00267	R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7	-	-	PTS_EIIC
TLS2_k127_6698931_13	994479.GL877879_gene5551	1.3e-86	295.0	COG2188@1|root,COG2188@2|Bacteria,2GJZ1@201174|Actinobacteria,4E1C3@85010|Pseudonocardiales	201174|Actinobacteria	K	GntR family	hutC	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS2_k127_6698931_8	471852.Tcur_4031	1.15e-116	389.0	COG1820@1|root,COG1820@2|Bacteria,2GK1E@201174|Actinobacteria,4EFH6@85012|Streptosporangiales	201174|Actinobacteria	G	Amidohydrolase family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS2_k127_6698931_6	1120950.KB892804_gene1468	5.945e-134	448.0	COG2222@1|root,COG2222@2|Bacteria,2I433@201174|Actinobacteria,4DR3Q@85009|Propionibacteriales	201174|Actinobacteria	M	SIS domain	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
TLS2_k127_6698931_21	1121017.AUFG01000015_gene2652	2.749e-28	123.0	COG1264@1|root,COG1264@2|Bacteria,2IQIB@201174|Actinobacteria	201174|Actinobacteria	G	phosphotransferase system	ptsB	-	2.7.1.193	ko:K02803	ko00520,ko02060,map00520,map02060	M00267	R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7	-	-	PTS_EIIB
TLS2_k127_6698931_19	1394178.AWOO02000005_gene3616	2.815e-51	191.0	COG2190@1|root,COG2190@2|Bacteria,2GK6B@201174|Actinobacteria,4EJES@85012|Streptosporangiales	201174|Actinobacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1	ptbA	-	2.7.1.193	ko:K02777,ko:K02802	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	M00265,M00266,M00267,M00268,M00270,M00272,M00303,M00806	R02738,R02780,R04111,R04394,R05132,R05199,R08559	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.2	-	-	PTS_EIIA_1
TLS2_k127_6698931_20	1304865.JAGF01000001_gene3913	1.026e-43	170.0	COG0637@1|root,COG0637@2|Bacteria	2|Bacteria	S	phosphonoacetaldehyde hydrolase activity	-	-	3.1.3.23,3.5.4.5	ko:K01489,ko:K19270	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	HAD_2,dCMP_cyt_deam_1
TLS2_k127_6698931_1	42256.RradSPS_0316	9.492e-200	638.0	COG0733@1|root,COG0733@2|Bacteria,2GIU3@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	metP	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
TLS2_k127_6698931_4	1157638.KB892157_gene1322	6.668e-185	591.0	COG0446@1|root,COG0446@2|Bacteria,2H7WY@201174|Actinobacteria	201174|Actinobacteria	P	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_6698931_7	188626.HMPREF0321_1869	3.655e-120	394.0	COG0647@1|root,COG0647@2|Bacteria,2GJG6@201174|Actinobacteria,1ZWGS@145357|Dermacoccaceae	201174|Actinobacteria	G	Belongs to the HAD-like hydrolase superfamily	nagD	-	-	ko:K02566	-	-	-	-	ko00000	-	-	-	Hydrolase_6,Hydrolase_like
TLS2_k127_6698931_10	1048339.KB913029_gene1452	6.313e-102	337.0	COG0566@1|root,COG0566@2|Bacteria,2GM1A@201174|Actinobacteria,4ERY0@85013|Frankiales	201174|Actinobacteria	J	SpoU rRNA Methylase family	trmH	-	2.1.1.34	ko:K00556	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
TLS2_k127_6698931_9	543632.JOJL01000004_gene4132	1.394e-107	376.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4DB80@85008|Micromonosporales	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	degS	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_6698931_17	1122611.KB903952_gene5916	2.781e-58	214.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria,4EHK4@85012|Streptosporangiales	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_6698931_18	390989.JOEG01000020_gene2731	6.367e-53	194.0	COG1131@1|root,COG1131@2|Bacteria,2GP3F@201174|Actinobacteria,4DCSH@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K15555	ko00920,ko02010,map00920,map02010	M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.17.2	-	-	ABC_tran
TLS2_k127_6698931_24	1120949.KB903304_gene7021	7.474e-16	89.0	2ASCZ@1|root,31HSE@2|Bacteria,2IEI1@201174|Actinobacteria,4DDYC@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6698931_22	543632.JOJL01000020_gene542	5.975e-19	100.0	2E76N@1|root,338EF@2|Bacteria,2GRXJ@201174|Actinobacteria,4DMAQ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6698931_2	1380356.JNIK01000019_gene398	5.07e-194	618.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
TLS2_k127_6698931_12	1348338.ADILRU_2011	1.799e-89	310.0	COG2035@1|root,COG2035@2|Bacteria,2I8HU@201174|Actinobacteria,4FN4C@85023|Microbacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF368)	-	-	-	ko:K08974	-	-	-	-	ko00000	-	-	-	DUF368
TLS2_k127_6698931_25	1043493.BBLU01000014_gene1202	2.774e-09	66.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria	201174|Actinobacteria	J	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
TLS2_k127_6698931_16	479435.Kfla_6731	1.571e-71	256.0	COG0461@1|root,COG0461@2|Bacteria,2GKUQ@201174|Actinobacteria,4DQ99@85009|Propionibacteriales	201174|Actinobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
TLS2_k127_6698931_14	1229781.C272_02305	3.806e-80	281.0	COG3274@1|root,COG3274@2|Bacteria,2INKC@201174|Actinobacteria,4F8CU@85019|Brevibacteriaceae	201174|Actinobacteria	S	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS2_k127_6698931_11	1385519.N801_00340	2.181e-96	326.0	COG0412@1|root,COG0412@2|Bacteria,2GK7H@201174|Actinobacteria,4FFR8@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS2_k127_6698931_15	211114.JOEF01000009_gene1739	7.757e-76	262.0	COG0300@1|root,COG0300@2|Bacteria,2GKJE@201174|Actinobacteria,4E0RD@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
TLS2_k127_6698931_5	479435.Kfla_6757	4.285e-168	536.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4DN5T@85009|Propionibacteriales	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	dapC	-	2.6.1.1,2.6.1.17	ko:K00812,ko:K10907,ko:K14267	ko00220,ko00250,ko00270,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016	R00355,R00694,R00734,R00896,R02433,R02619,R04475,R05052	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_6698931_23	1380354.JIAN01000005_gene1466	8.793e-19	91.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,2GKCX@201174|Actinobacteria	201174|Actinobacteria	K	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
TLS2_k127_6716628_7	1123320.KB889688_gene433	1.414e-45	186.0	COG1295@1|root,COG1295@2|Bacteria,2GN79@201174|Actinobacteria	201174|Actinobacteria	S	Ribonuclease	yhjD	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_6716628_5	1120950.KB892760_gene5749	9.989e-74	254.0	COG1514@1|root,COG1514@2|Bacteria,2GRF0@201174|Actinobacteria,4DRBR@85009|Propionibacteriales	201174|Actinobacteria	J	LigT like Phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
TLS2_k127_6716628_3	219305.MCAG_03557	3.315e-150	483.0	COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria,4DAKB@85008|Micromonosporales	201174|Actinobacteria	J	Tryptophanyl-tRNA synthetase	trpS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS2_k127_6716628_1	397278.JOJN01000007_gene3445	8.85e-231	719.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria,4DNU0@85009|Propionibacteriales	201174|Actinobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
TLS2_k127_6716628_0	1394178.AWOO02000001_gene1496	3.371e-274	854.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4EFSX@85012|Streptosporangiales	201174|Actinobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.2.4	ko:K00102,ko:K11472	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_6716628_8	1394178.AWOO02000001_gene1497	9.291e-30	130.0	28RGR@1|root,2ZDVS@2|Bacteria,2GR2V@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6716628_2	1169161.KB897730_gene1080	4.352e-157	501.0	COG2141@1|root,COG2141@2|Bacteria,2GJ04@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
TLS2_k127_6716628_6	1120950.KB892707_gene4598	4.144e-66	231.0	COG4636@1|root,COG4636@2|Bacteria,2IGTR@201174|Actinobacteria,4DRGB@85009|Propionibacteriales	201174|Actinobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS2_k127_6716628_4	1120950.KB892760_gene5747	4.235e-146	470.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4DPDV@85009|Propionibacteriales	201174|Actinobacteria	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_6752130_3	463191.SSEG_11108	4.899e-63	232.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria	201174|Actinobacteria	S	Dihydroxyacetone kinase	dak3	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
TLS2_k127_6752130_0	452652.KSE_51580	3.729e-249	789.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,2M1S9@2063|Kitasatospora	201174|Actinobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge,tRNA_anti-codon
TLS2_k127_6752130_4	1463856.JOHY01000025_gene3849	4.179e-62	224.0	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria	201174|Actinobacteria	L	methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
TLS2_k127_6752130_1	1896.JOAU01000029_gene5515	1.611e-71	244.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria	201174|Actinobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_6752130_2	1003195.SCAT_4406	2.701e-66	237.0	COG1399@1|root,COG1399@2|Bacteria,2GJTS@201174|Actinobacteria	201174|Actinobacteria	S	metal-binding, possibly nucleic acid-binding protein	-	GO:0008150,GO:0040007	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
TLS2_k127_6752130_5	1122175.ATXU01000008_gene334	1.263e-10	66.0	COG0333@1|root,COG0333@2|Bacteria,2HSQ4@201174|Actinobacteria,4FPTP@85023|Microbacteriaceae	201174|Actinobacteria	J	structural constituent of ribosome	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
TLS2_k127_6753794_16	1463821.JOGR01000013_gene3345	2.225e-08	55.0	COG0396@1|root,COG0396@2|Bacteria,2GKB7@201174|Actinobacteria,4EY1C@85014|Glycomycetales	201174|Actinobacteria	O	ATPases associated with a variety of cellular activities	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
TLS2_k127_6753794_1	882086.SacxiDRAFT_0220	1.984e-203	642.0	COG0520@1|root,COG0520@2|Bacteria,2GIVK@201174|Actinobacteria,4DYBX@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
TLS2_k127_6753794_11	1179773.BN6_62280	2.694e-52	206.0	COG0822@1|root,COG0822@2|Bacteria,2IHY9@201174|Actinobacteria,4E2WE@85010|Pseudonocardiales	201174|Actinobacteria	C	SUF system FeS assembly protein, NifU family	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS2_k127_6753794_12	1122138.AQUZ01000001_gene1561	3.243e-49	190.0	COG2151@1|root,COG2151@2|Bacteria,2IKUH@201174|Actinobacteria,4DR2I@85009|Propionibacteriales	201174|Actinobacteria	S	Pfam:DUF59	yitW	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
TLS2_k127_6753794_0	367299.JOEE01000001_gene1735	6.357e-206	653.0	COG1115@1|root,COG1115@2|Bacteria,2GIU2@201174|Actinobacteria,4FE35@85021|Intrasporangiaceae	201174|Actinobacteria	E	Sodium:alanine symporter family	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
TLS2_k127_6753794_13	1184609.KILIM_025_00450	4.979e-40	158.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_6753794_8	1120950.KB892708_gene4335	1.475e-92	308.0	COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,4DQIB@85009|Propionibacteriales	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TLS2_k127_6753794_4	105420.BBPO01000139_gene3616	1.36e-147	473.0	COG0223@1|root,COG0223@2|Bacteria,2GKH5@201174|Actinobacteria,2NH3A@228398|Streptacidiphilus	201174|Actinobacteria	J	Formyl transferase, C-terminal domain	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TLS2_k127_6753794_3	953739.SVEN_1068	1.687e-175	561.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2GM21@201174|Actinobacteria	201174|Actinobacteria	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	fmu	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
TLS2_k127_6753794_7	436229.JOEH01000002_gene3246	2.15e-95	336.0	COG0036@1|root,COG0036@2|Bacteria,2GJZ9@201174|Actinobacteria,2NFMJ@228398|Streptacidiphilus	201174|Actinobacteria	G	Ribulose-phosphate 3 epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TLS2_k127_6753794_6	2045.KR76_12360	3.345e-123	405.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2GKAX@201174|Actinobacteria,4DNKD@85009|Propionibacteriales	201174|Actinobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016020,GO:0016070,GO:0034641,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
TLS2_k127_6753794_9	1123322.KB904634_gene2403	6.578e-79	267.0	COG0307@1|root,COG0307@2|Bacteria,2GKC5@201174|Actinobacteria	201174|Actinobacteria	H	riboflavin synthase, alpha	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
TLS2_k127_6753794_2	196162.Noca_2449	5.159e-189	612.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GIWJ@201174|Actinobacteria,4DNA4@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
TLS2_k127_6753794_10	67352.JODS01000023_gene3342	1.618e-62	228.0	COG0054@1|root,COG0054@2|Bacteria,2II1Z@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
TLS2_k127_6753794_14	526225.Gobs_3109	6.004e-34	132.0	COG0140@1|root,COG0140@2|Bacteria,2IQ4D@201174|Actinobacteria,4ETDD@85013|Frankiales	201174|Actinobacteria	E	Belongs to the PRA-PH family	hisE	GO:0000287,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0044403,GO:0044419,GO:0044464,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0071944,GO:0075136,GO:0075139	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
TLS2_k127_6753794_5	1120950.KB892707_gene4712	2.978e-127	412.0	COG0040@1|root,COG0040@2|Bacteria,2GNAX@201174|Actinobacteria,4DNZB@85009|Propionibacteriales	201174|Actinobacteria	E	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
TLS2_k127_6753794_15	298653.Franean1_6198	4.231e-12	69.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4ERZB@85013|Frankiales	201174|Actinobacteria	S	PFAM ATPase associated with various cellular activities AAA_5	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
TLS2_k127_6761348_3	35754.JNYJ01000023_gene8304	2.463e-114	376.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4DBQV@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6761348_5	446466.Cfla_2681	2.882e-98	333.0	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria,4F0I9@85016|Cellulomonadaceae	201174|Actinobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
TLS2_k127_6761348_7	367299.JOEE01000001_gene1742	2.237e-79	289.0	COG4585@1|root,COG4585@2|Bacteria,2GJKG@201174|Actinobacteria,4FFB8@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_6761348_11	118173.KB235914_gene921	2.529e-18	88.0	COG0454@1|root,COG0456@2|Bacteria,1G5GC@1117|Cyanobacteria	1117|Cyanobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
TLS2_k127_6761348_8	1122138.AQUZ01000036_gene5479	5.996e-78	273.0	COG0500@1|root,COG2226@2|Bacteria,2HWAV@201174|Actinobacteria,4DQJ7@85009|Propionibacteriales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_6761348_6	593907.Celgi_0782	2.374e-89	298.0	COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria,4F25T@85016|Cellulomonadaceae	201174|Actinobacteria	K	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_6761348_4	1380393.JHVP01000005_gene3552	1.41e-100	338.0	COG3173@1|root,COG3173@2|Bacteria,2GKUU@201174|Actinobacteria	201174|Actinobacteria	K	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_6761348_0	1193181.BN10_1170026	0.0	1017.0	COG2185@1|root,COG2185@2|Bacteria,2I2N3@201174|Actinobacteria,4FEHX@85021|Intrasporangiaceae	201174|Actinobacteria	I	Methylmalonyl-CoA mutase	meaA	-	5.4.99.63	ko:K14447	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09292	RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
TLS2_k127_6761348_9	281090.Lxx19820	1.985e-41	173.0	COG0490@1|root,COG0490@2|Bacteria,2IFBQ@201174|Actinobacteria,4FN5Y@85023|Microbacteriaceae	201174|Actinobacteria	P	TrkA-C domain	-	-	-	ko:K07228	-	-	-	-	ko00000	-	-	-	TrkA_C
TLS2_k127_6761348_2	263358.VAB18032_18740	2.411e-132	443.0	COG0475@1|root,COG5207@1|root,COG0475@2|Bacteria,COG5207@2|Bacteria,2GJ69@201174|Actinobacteria,4DACZ@85008|Micromonosporales	201174|Actinobacteria	P	Sodium hydrogen exchanger	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N,zf-UBP
TLS2_k127_6761348_1	298653.Franean1_2259	2.036e-238	776.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,2GK62@201174|Actinobacteria,4ERPW@85013|Frankiales	201174|Actinobacteria	KOT	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,Response_reg
TLS2_k127_6761348_10	1463856.JOHY01000029_gene2682	1.76e-19	90.0	COG4191@1|root,COG4191@2|Bacteria,2GMRD@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,cNMP_binding
TLS2_k127_6784261_4	590998.Celf_2581	2.765e-12	75.0	COG3064@1|root,COG3064@2|Bacteria,2I3NK@201174|Actinobacteria	201174|Actinobacteria	M	Host cell surface-exposed lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_Ltp,PASTA
TLS2_k127_6784261_2	1121017.AUFG01000005_gene999	4.634e-34	136.0	COG2445@1|root,COG2445@2|Bacteria,2IQ2Y@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
TLS2_k127_6784261_5	926550.CLDAP_20240	0.0005852	48.0	COG1669@1|root,COG1669@2|Bacteria,2G76P@200795|Chloroflexi	200795|Chloroflexi	L	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
TLS2_k127_6784261_0	1380347.JNII01000006_gene1901	3.742e-254	820.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4ETGG@85013|Frankiales	201174|Actinobacteria	K	transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_22,BTAD,NB-ARC,TPR_12,Trans_reg_C
TLS2_k127_6784261_1	1380347.JNII01000006_gene1903	2.11e-95	335.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4EV42@85013|Frankiales	201174|Actinobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS2_k127_6784261_3	196162.Noca_3746	6.158e-17	86.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4DTJX@85009|Propionibacteriales	201174|Actinobacteria	P	Heavy-metal-associated domain	-	-	3.6.3.3,3.6.3.4,3.6.3.5,3.6.3.54	ko:K01533,ko:K01534,ko:K12954,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3,3.A.3.5,3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS2_k127_6803685_9	68170.KL590544_gene751	0.0001086	45.0	COG2203@1|root,COG2203@2|Bacteria,2GQ2V@201174|Actinobacteria,4E2XH@85010|Pseudonocardiales	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS2_k127_6803685_4	1120948.KB903246_gene3390	1.405e-147	498.0	COG2208@1|root,COG2208@2|Bacteria,2GKEF@201174|Actinobacteria,4EEDR@85010|Pseudonocardiales	201174|Actinobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,PAS_8,PAS_9,SpoIIE
TLS2_k127_6803685_3	266779.Meso_2825	4.936e-166	538.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,43IK5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	pcaF	-	2.3.1.16,2.3.1.174,2.3.1.9	ko:K00626,ko:K00632,ko:K07823	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_6803685_7	670292.JH26_27120	1.763e-44	179.0	COG2050@1|root,COG2050@2|Bacteria,1RH35@1224|Proteobacteria,2U5QW@28211|Alphaproteobacteria,1JV7J@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	Phenylacetic acid degradation protein PaaD	paaI	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
TLS2_k127_6803685_2	1120950.KB892771_gene1311	8.836e-177	572.0	COG1250@1|root,COG1250@2|Bacteria,2GPFP@201174|Actinobacteria,4DWPX@85009|Propionibacteriales	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	paaH	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_6803685_0	219305.MCAG_02316	6.113e-231	730.0	COG1012@1|root,COG1012@2|Bacteria,2GNJJ@201174|Actinobacteria,4DA95@85008|Micromonosporales	201174|Actinobacteria	C	phenylacetic acid degradation protein paaN	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_6803685_8	1172188.KB911821_gene1243	2.177e-15	79.0	29518@1|root,2ZSE2@2|Bacteria,2GZ19@201174|Actinobacteria,4FI3U@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6803685_5	1304865.JAGF01000001_gene924	1.666e-96	337.0	COG2141@1|root,COG2141@2|Bacteria,2GJI7@201174|Actinobacteria,4F14F@85016|Cellulomonadaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_6803685_6	585531.HMPREF0063_12749	4.013e-71	249.0	2DMG6@1|root,32RB5@2|Bacteria,2GMQI@201174|Actinobacteria	201174|Actinobacteria	S	MDMPI C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
TLS2_k127_6803685_1	1120950.KB892744_gene2775	8.743e-211	662.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria,4DP01@85009|Propionibacteriales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_6805084_1	1394178.AWOO02000046_gene6489	6.015e-101	346.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4EH3N@85012|Streptosporangiales	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
TLS2_k127_6805084_0	477641.MODMU_4784	2.662e-103	376.0	COG2319@1|root,COG3391@1|root,COG3629@1|root,COG2319@2|Bacteria,COG3391@2|Bacteria,COG3629@2|Bacteria,2GJN3@201174|Actinobacteria,4ES8H@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,PD40,Trans_reg_C,WD40
TLS2_k127_6805084_2	1229780.BN381_20089	1.227e-39	171.0	COG1744@1|root,COG1744@2|Bacteria,2GMFS@201174|Actinobacteria,3UWJF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	ABC transporter substrate-binding protein PnrA-like	bmpA	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
TLS2_k127_6815073_4	1306174.JODP01000003_gene2065	2.303e-18	86.0	COG0277@1|root,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria	201174|Actinobacteria	C	FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
TLS2_k127_6815073_0	390989.JOEG01000004_gene3736	9.103e-200	629.0	COG1672@1|root,COG1672@2|Bacteria,2GWBV@201174|Actinobacteria,4DB9A@85008|Micromonosporales	201174|Actinobacteria	C	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
TLS2_k127_6815073_1	1463825.JNXC01000020_gene6592	2.436e-144	475.0	COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria,4E023@85010|Pseudonocardiales	201174|Actinobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_6815073_3	1146883.BLASA_2384	7.637e-25	110.0	2BYGI@1|root,333FU@2|Bacteria,2GRMH@201174|Actinobacteria,4EWXH@85013|Frankiales	201174|Actinobacteria	M	Subtilisin inhibitor-like	-	-	-	-	-	-	-	-	-	-	-	-	SSI
TLS2_k127_6815073_2	1394178.AWOO02000011_gene4001	1.552e-124	403.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria,4EFGJ@85012|Streptosporangiales	201174|Actinobacteria	L	Formamidopyrimidine-DNA glycosylase N-terminal domain	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_6819100_1	1236902.ANAS01000009_gene2620	1.223e-59	212.0	COG1595@1|root,COG1595@2|Bacteria,2GKFQ@201174|Actinobacteria,4EGWT@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6819100_2	1237500.ANBA01000009_gene1431	8.798e-45	165.0	COG0537@1|root,COG0537@2|Bacteria,2IHPT@201174|Actinobacteria,4EJSG@85012|Streptosporangiales	201174|Actinobacteria	FG	HIT domain	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
TLS2_k127_6819100_0	479435.Kfla_2421	1.264e-103	342.0	COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria,4DPI2@85009|Propionibacteriales	201174|Actinobacteria	T	PhoH-like protein	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
TLS2_k127_6848016_1	1298863.AUEP01000001_gene786	4.148e-60	209.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4DNEX@85009|Propionibacteriales	201174|Actinobacteria	V	COG1136 ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_6848016_0	1298863.AUEP01000001_gene787	3.85e-164	525.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4DWWD@85009|Propionibacteriales	201174|Actinobacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_688568_0	1120950.KB892740_gene2514	0.0	1205.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4DN2Z@85009|Propionibacteriales	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0008094,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034335,GO:0042623,GO:0061505,GO:0140097	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS2_k127_688568_2	351607.Acel_0005	2.5e-323	1002.0	COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,4ES0Z@85013|Frankiales	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS2_k127_688568_39	1120950.KB892740_gene2516	2.31e-51	195.0	COG5512@1|root,COG5512@2|Bacteria,2GNQ4@201174|Actinobacteria,4DR8Q@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
TLS2_k127_688568_8	1048339.KB913029_gene1671	2.699e-165	531.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4ES7H@85013|Frankiales	201174|Actinobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
TLS2_k127_688568_13	2074.JNYD01000004_gene4867	6.564e-147	471.0	COG1023@1|root,COG1023@2|Bacteria,2I2DH@201174|Actinobacteria,4DYVC@85010|Pseudonocardiales	201174|Actinobacteria	G	6-phosphogluconate dehydrogenase	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
TLS2_k127_688568_10	1120950.KB892740_gene2519	8.659e-160	511.0	COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria,4DN43@85009|Propionibacteriales	201174|Actinobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
TLS2_k127_688568_5	1120950.KB892740_gene2520	3.005e-203	644.0	COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria,4DMZ1@85009|Propionibacteriales	201174|Actinobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C
TLS2_k127_688568_50	1210045.ALNP01000002_gene4105	6.727e-15	75.0	COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
TLS2_k127_688568_47	590998.Celf_3809	6.173e-26	111.0	COG0594@1|root,COG0594@2|Bacteria,2GR42@201174|Actinobacteria,4F30D@85016|Cellulomonadaceae	201174|Actinobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	GO:0008150,GO:0040007	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
TLS2_k127_688568_45	465515.Mlut_23460	6.006e-30	123.0	COG0759@1|root,COG0759@2|Bacteria,2GQZG@201174|Actinobacteria,1W9QQ@1268|Micrococcaceae	201174|Actinobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
TLS2_k127_688568_26	1120950.KB892740_gene2522	1.521e-98	331.0	COG0706@1|root,COG0706@2|Bacteria,2GJBU@201174|Actinobacteria,4DNB3@85009|Propionibacteriales	201174|Actinobacteria	U	60Kd inner membrane protein	yidC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
TLS2_k127_688568_31	67373.JOBF01000004_gene821	3.159e-65	228.0	COG1847@1|root,COG1847@2|Bacteria,2GPZK@201174|Actinobacteria	201174|Actinobacteria	S	R3H domain protein	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	KH_4,R3H
TLS2_k127_688568_34	68260.JOAY01000042_gene1978	2.625e-63	227.0	COG0357@1|root,COG0357@2|Bacteria,2GM9Z@201174|Actinobacteria	201174|Actinobacteria	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
TLS2_k127_688568_15	68223.JNZY01000003_gene4769	4.504e-131	430.0	COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria	201174|Actinobacteria	D	chromosome partitioning	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS2_k127_688568_18	1095767.CAHD01000059_gene454	2.511e-126	416.0	COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,4F0RN@85016|Cellulomonadaceae	201174|Actinobacteria	K	PFAM ParB domain protein nuclease	parB	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
TLS2_k127_688568_16	1120950.KB892740_gene2527	5.931e-130	426.0	COG1181@1|root,COG1181@2|Bacteria,2GRWM@201174|Actinobacteria,4DNS4@85009|Propionibacteriales	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TLS2_k127_688568_4	196162.Noca_4690	1.141e-211	668.0	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria,4DPAN@85009|Propionibacteriales	201174|Actinobacteria	EK	Alanine-glyoxylate amino-transferase	avtA	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
TLS2_k127_688568_24	469371.Tbis_3580	7.577e-104	340.0	COG3153@1|root,COG3153@2|Bacteria,2GNNB@201174|Actinobacteria,4DXW4@85010|Pseudonocardiales	201174|Actinobacteria	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_688568_11	1120950.KB892740_gene2531	3.537e-150	484.0	COG0860@1|root,COG3409@1|root,COG0860@2|Bacteria,COG3409@2|Bacteria,2GPA9@201174|Actinobacteria,4DN51@85009|Propionibacteriales	201174|Actinobacteria	M	Ami_3	cwlM	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,PG_binding_1
TLS2_k127_688568_41	110319.CF8_3784	6.949e-46	168.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4DRDT@85009|Propionibacteriales	201174|Actinobacteria	O	Belongs to the thioredoxin family	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS2_k127_688568_12	479435.Kfla_7063	5.451e-147	472.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,4DPPP@85009|Propionibacteriales	201174|Actinobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_688568_53	455632.SGR_3688	1.37e-09	70.0	COG5662@1|root,COG5662@2|Bacteria,2HUF6@201174|Actinobacteria,41B3R@629295|Streptomyces griseus group	201174|Actinobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_688568_33	1123320.KB889730_gene6018	2.78e-64	228.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	sigM	GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_688568_25	1120950.KB892740_gene2536	4.557e-102	351.0	COG0515@1|root,COG0515@2|Bacteria,2GM4A@201174|Actinobacteria,4DN49@85009|Propionibacteriales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS2_k127_688568_17	1298863.AUEP01000006_gene3472	5.857e-128	436.0	COG0728@1|root,COG0728@2|Bacteria,2GKN0@201174|Actinobacteria,4DNJI@85009|Propionibacteriales	201174|Actinobacteria	KLT	MviN-like protein	mviN	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TLS2_k127_688568_38	1906.SFRA_12640	1.39e-52	213.0	COG3170@1|root,COG3170@2|Bacteria,2GN00@201174|Actinobacteria	201174|Actinobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_688568_36	40571.JOEA01000020_gene7668	2.176e-56	204.0	COG1051@1|root,COG1051@2|Bacteria,2I2DG@201174|Actinobacteria,4E30H@85010|Pseudonocardiales	201174|Actinobacteria	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_688568_3	1123320.KB889730_gene6023	2.398e-219	689.0	COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria	201174|Actinobacteria	J	tRNA nucleotidyltransferase poly(A) polymerase	pcnA	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
TLS2_k127_688568_20	1120950.KB892740_gene2540	1.271e-123	412.0	COG2270@1|root,COG2270@2|Bacteria,2GK5A@201174|Actinobacteria,4DQ23@85009|Propionibacteriales	201174|Actinobacteria	S	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_688568_28	656024.FsymDg_3904	1.583e-82	278.0	COG2229@1|root,COG2229@2|Bacteria,2GJIT@201174|Actinobacteria	201174|Actinobacteria	S	ATP- GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
TLS2_k127_688568_52	269800.Tfu_1431	1.57e-10	69.0	COG1846@1|root,COG1846@2|Bacteria,2II7H@201174|Actinobacteria	201174|Actinobacteria	K	Protein of unknown function (DUF742)	-	-	-	-	-	-	-	-	-	-	-	-	DUF742
TLS2_k127_688568_42	33876.JNXY01000026_gene3518	4.492e-43	160.0	COG2018@1|root,COG2018@2|Bacteria,2IFB7@201174|Actinobacteria,4DD3M@85008|Micromonosporales	201174|Actinobacteria	S	Roadblock lc7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
TLS2_k127_688568_27	1120936.KB907211_gene485	1.806e-89	329.0	COG4251@1|root,COG4251@2|Bacteria,2GK6E@201174|Actinobacteria,4EGNB@85012|Streptosporangiales	201174|Actinobacteria	T	Nitrate and nitrite sensing	cvnA6	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,NIT
TLS2_k127_688568_6	479435.Kfla_7020	2.347e-201	640.0	COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4DNQF@85009|Propionibacteriales	201174|Actinobacteria	I	Myo-inositol-1-phosphate synthase	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
TLS2_k127_688568_29	105422.BBPM01000059_gene731	2.827e-79	271.0	COG1695@1|root,COG1695@2|Bacteria,2GMJM@201174|Actinobacteria,2NG3F@228398|Streptacidiphilus	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
TLS2_k127_688568_7	1120950.KB892740_gene2544	3.801e-198	644.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4DMYZ@85009|Propionibacteriales	201174|Actinobacteria	M	Transglycosylase	pbp5	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
TLS2_k127_688568_19	1048339.KB913029_gene1636	7.924e-126	420.0	COG5650@1|root,COG5650@2|Bacteria,2GJYA@201174|Actinobacteria,4ES94@85013|Frankiales	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
TLS2_k127_688568_21	1120950.KB892740_gene2546	3.213e-117	396.0	COG5542@1|root,COG5542@2|Bacteria,2HZNP@201174|Actinobacteria,4DTDM@85009|Propionibacteriales	201174|Actinobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
TLS2_k127_688568_40	101510.RHA1_ro05202	5.457e-46	180.0	COG5340@1|root,COG5340@2|Bacteria,2II40@201174|Actinobacteria,4G06Z@85025|Nocardiaceae	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4
TLS2_k127_688568_23	1032480.MLP_01140	3.254e-106	355.0	COG0787@1|root,COG0787@2|Bacteria,2GJJX@201174|Actinobacteria,4DNS3@85009|Propionibacteriales	201174|Actinobacteria	M	Alanine racemase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N
TLS2_k127_688568_9	1033730.CAHG01000006_gene1189	4.575e-164	528.0	COG2348@1|root,COG2348@2|Bacteria,2GJUD@201174|Actinobacteria,4DPII@85009|Propionibacteriales	201174|Actinobacteria	V	FemAB family	femX	-	2.3.2.10	ko:K05363	ko00550,ko01100,map00550,map01100	-	R08779	RC00055,RC00096	ko00000,ko00001,ko01000,ko01011	-	-	-	FemAB
TLS2_k127_688568_32	28444.JODQ01000009_gene3816	2.408e-64	226.0	COG2353@1|root,COG2353@2|Bacteria,2GJUB@201174|Actinobacteria,4EIQ8@85012|Streptosporangiales	201174|Actinobacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
TLS2_k127_688568_37	390989.JOEG01000004_gene3972	2.529e-56	203.0	COG1846@1|root,COG1846@2|Bacteria,2IPBX@201174|Actinobacteria,4DCPX@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_688568_22	1032480.MLP_53100	1.47e-114	382.0	COG0648@1|root,COG0648@2|Bacteria,2GJJQ@201174|Actinobacteria,4DN5G@85009|Propionibacteriales	201174|Actinobacteria	L	Xylose isomerase-like TIM barrel	nfo	GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
TLS2_k127_688568_48	1123322.KB904669_gene3607	2.528e-17	89.0	28SVW@1|root,2ZF5E@2|Bacteria,2IKTQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_688568_44	479435.Kfla_7001	2.163e-36	156.0	COG0360@1|root,COG0360@2|Bacteria,2IQHD@201174|Actinobacteria,4DRPR@85009|Propionibacteriales	201174|Actinobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
TLS2_k127_688568_30	196162.Noca_4663	1.471e-70	249.0	COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,4DQ95@85009|Propionibacteriales	201174|Actinobacteria	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_688568_43	1449346.JQMO01000003_gene4412	3.764e-40	150.0	COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,2M3HN@2063|Kitasatospora	201174|Actinobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
TLS2_k127_688568_35	1048339.KB913029_gene1600	1.984e-56	200.0	COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria,4ESST@85013|Frankiales	201174|Actinobacteria	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
TLS2_k127_688568_14	1463900.JOIX01000001_gene6554	2.265e-142	473.0	COG0534@1|root,COG0534@2|Bacteria,2GJE3@201174|Actinobacteria	201174|Actinobacteria	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
TLS2_k127_688568_1	67373.JOBF01000004_gene847	0.0	1077.0	COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria	201174|Actinobacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
TLS2_k127_688568_51	1120949.KB903299_gene6065	4.487e-11	65.0	COG1309@1|root,COG1309@2|Bacteria,2IM68@201174|Actinobacteria,4DFVM@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_688568_46	543632.JOJL01000064_gene1449	1.431e-29	131.0	2B4SD@1|root,31XIT@2|Bacteria,2II69@201174|Actinobacteria,4DFTU@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS2_k127_688568_54	1297569.MESS2_650113	1.873e-09	66.0	COG1018@1|root,COG1018@2|Bacteria,1NY0N@1224|Proteobacteria,2UTE1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6891811_1	110319.CF8_2448	5.616e-164	524.0	COG0621@1|root,COG0621@2|Bacteria,2GKRI@201174|Actinobacteria,4DNHY@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
TLS2_k127_6891811_7	1089455.MOPEL_009_00710	2.65e-71	246.0	COG0558@1|root,COG0558@2|Bacteria,2GK5D@201174|Actinobacteria,4F6VF@85018|Dermatophilaceae	201174|Actinobacteria	I	CDP-alcohol phosphatidyltransferase	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_6891811_6	1120936.KB907220_gene2005	3.281e-94	333.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2IQ8T@201174|Actinobacteria,4EJK6@85012|Streptosporangiales	201174|Actinobacteria	S	Competence-damaged protein	cinA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
TLS2_k127_6891811_11	455632.SGR_1766	1.577e-30	126.0	COG1396@1|root,COG1396@2|Bacteria,2GR3F@201174|Actinobacteria,41ATT@629295|Streptomyces griseus group	201174|Actinobacteria	K	Helix-turn-helix	clgR	GO:0002682,GO:0002683,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006109,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009268,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009987,GO:0010447,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0010675,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0022611,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031347,GO:0031348,GO:0032268,GO:0032502,GO:0033554,GO:0035821,GO:0040007,GO:0042176,GO:0043207,GO:0043565,GO:0043620,GO:0044003,GO:0044110,GO:0044111,GO:0044114,GO:0044115,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051252,GO:0051254,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060255,GO:0061136,GO:0062012,GO:0065007,GO:0075136,GO:0080090,GO:0080134,GO:0085016,GO:0090062,GO:0097159,GO:1901363,GO:1902680,GO:1902882,GO:1903050,GO:1903362,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_31
TLS2_k127_6891811_5	1157637.KB892116_gene88	8.194e-104	344.0	COG0266@1|root,COG0266@2|Bacteria,2GKCW@201174|Actinobacteria	201174|Actinobacteria	L	Glycosylase	nei	-	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_6891811_15	33876.JNXY01000008_gene8472	1.815e-19	98.0	COG1940@1|root,COG1940@2|Bacteria,2GJ3W@201174|Actinobacteria,4DAV0@85008|Micromonosporales	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2,ROK
TLS2_k127_6891811_10	1121946.AUAX01000001_gene2555	1.81e-33	142.0	COG1940@1|root,COG1940@2|Bacteria,2GJ3W@201174|Actinobacteria,4DAV0@85008|Micromonosporales	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2,ROK
TLS2_k127_6891811_9	479431.Namu_4106	5.446e-45	178.0	COG3224@1|root,COG3224@2|Bacteria,2GY26@201174|Actinobacteria,4EWAV@85013|Frankiales	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	ko:K09932	-	-	-	-	ko00000	-	-	-	ABM
TLS2_k127_6891811_12	675635.Psed_0215	1.3e-23	113.0	COG1853@1|root,COG1853@2|Bacteria,2INYP@201174|Actinobacteria,4EEX2@85010|Pseudonocardiales	201174|Actinobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TLS2_k127_6891811_8	685778.AORL01000022_gene1509	4.55e-49	179.0	COG0454@1|root,COG0454@2|Bacteria,1RIFC@1224|Proteobacteria,2UDE0@28211|Alphaproteobacteria,2KEPV@204457|Sphingomonadales	204457|Sphingomonadales	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
TLS2_k127_6891811_0	1048339.KB913029_gene3595	0.0	2141.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4ES42@85013|Frankiales	201174|Actinobacteria	L	DEAD DEAH box helicase domain protein	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
TLS2_k127_6891811_14	643867.Ftrac_2467	1.239e-20	101.0	COG3548@1|root,COG3548@2|Bacteria,4NW8Z@976|Bacteroidetes,47V92@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
TLS2_k127_6891811_13	1120950.KB892756_gene6693	4.457e-21	93.0	2AU8K@1|root,31JVT@2|Bacteria,2HZCZ@201174|Actinobacteria,4DS5N@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF3046)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3046
TLS2_k127_6891811_2	2074.JNYD01000012_gene385	1.3e-159	514.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria,4DYEJ@85010|Pseudonocardiales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
TLS2_k127_6891811_4	1288083.AUKR01000001_gene1336	9.096e-107	362.0	COG0477@1|root,COG2814@2|Bacteria,2GIR8@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_6891811_3	1137268.AZXF01000012_gene3487	7.354e-144	466.0	COG0468@1|root,COG1372@1|root,COG0468@2|Bacteria,COG1372@2|Bacteria,2GJ4P@201174|Actinobacteria,4EMPJ@85012|Streptosporangiales	201174|Actinobacteria	L	LAGLIDADG DNA endonuclease family	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TLS2_k127_6898227_0	1463855.JOHV01000014_gene4479	5.584e-187	599.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria	201174|Actinobacteria	P	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
TLS2_k127_6898227_6	55952.BU52_07710	6.222e-29	121.0	COG0607@1|root,COG0607@2|Bacteria,2IQ2S@201174|Actinobacteria	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_6898227_10	1435356.Y013_07050	0.0009356	49.0	COG3187@1|root,COG3187@2|Bacteria,2I9ND@201174|Actinobacteria,4FW9C@85025|Nocardiaceae	201174|Actinobacteria	O	META domain	hslJ	-	-	ko:K03668	-	-	-	-	ko00000	-	-	-	META
TLS2_k127_6898227_4	649831.L083_0740	3.085e-66	231.0	COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,4DDCY@85008|Micromonosporales	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TLS2_k127_6898227_5	1380354.JIAN01000005_gene2719	8.171e-58	219.0	COG1295@1|root,COG1295@2|Bacteria	2|Bacteria	S	lipopolysaccharide transmembrane transporter activity	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Glyco_hydro_2,Virul_fac_BrkB
TLS2_k127_6898227_1	1380393.JHVP01000014_gene4774	3.74e-182	597.0	COG0644@1|root,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria,4ERPF@85013|Frankiales	201174|Actinobacteria	C	geranylgeranyl reductase	menJ	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016491,GO:0016627,GO:0030312,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
TLS2_k127_6898227_2	861299.J421_4300	2.47e-167	540.0	COG2072@1|root,COG2072@2|Bacteria,1ZV95@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like
TLS2_k127_6898227_3	644283.Micau_0717	1.841e-100	336.0	COG0638@1|root,COG0638@2|Bacteria,2HIHG@201174|Actinobacteria,4DGTX@85008|Micromonosporales	201174|Actinobacteria	O	20S proteasome	-	-	-	-	-	-	-	-	-	-	-	-	Proteasome
TLS2_k127_6898227_7	1120949.KB903294_gene4679	1.813e-23	111.0	COG2197@1|root,COG2197@2|Bacteria,2IKTN@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_6898227_8	1089455.MOPEL_007_00130	6.541e-20	92.0	COG1961@1|root,COG1961@2|Bacteria,2I8IZ@201174|Actinobacteria	201174|Actinobacteria	L	Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_6899972_8	1122182.KB903837_gene3733	1.248e-64	226.0	COG1522@1|root,COG1522@2|Bacteria,2HVG9@201174|Actinobacteria,4DDPB@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS2_k127_6899972_1	710696.Intca_0094	9.101e-108	360.0	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,4FFM8@85021|Intrasporangiaceae	201174|Actinobacteria	I	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS2_k127_6899972_7	1136417.AZWE01000031_gene4776	3.624e-73	261.0	COG1506@1|root,COG1506@2|Bacteria,2I3Z4@201174|Actinobacteria,4DCIS@85008|Micromonosporales	201174|Actinobacteria	E	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Abhydrolase_6,Peptidase_S9
TLS2_k127_6899972_10	1343740.M271_26430	7.13e-22	107.0	2E3JZ@1|root,32YI8@2|Bacteria,2GQIX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4177
TLS2_k127_6899972_9	1298863.AUEP01000015_gene1790	2.301e-61	226.0	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria,4DQIS@85009|Propionibacteriales	201174|Actinobacteria	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
TLS2_k127_6899972_6	1123320.KB889692_gene160	2.35e-76	272.0	COG0494@1|root,COG0494@2|Bacteria,2GN6D@201174|Actinobacteria	201174|Actinobacteria	L	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_6899972_5	369723.Strop_4347	1.61e-77	267.0	COG0491@1|root,COG0491@2|Bacteria,2GKP9@201174|Actinobacteria,4D9MK@85008|Micromonosporales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	pksB_1	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_6899972_11	40571.JOEA01000001_gene5023	1.885e-05	53.0	2BTVD@1|root,32P37@2|Bacteria,2GZVD@201174|Actinobacteria,4E7M9@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6899972_2	1122609.AUGT01000011_gene3507	1.86e-106	349.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,4DMXW@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, cAMP Regulatory protein	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_6899972_0	1120950.KB892762_gene5486	3.256e-116	377.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4DNJN@85009|Propionibacteriales	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
TLS2_k127_6899972_3	1120950.KB892762_gene5484	1.6e-86	295.0	COG0494@1|root,COG0494@2|Bacteria,2GKG9@201174|Actinobacteria,4DQJF@85009|Propionibacteriales	201174|Actinobacteria	L	NUDIX domain	nudL	-	-	ko:K18568	ko00332,ko01130,map00332,map01130	-	R10747	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TLS2_k127_6899972_4	981369.JQMJ01000003_gene7796	4.954e-80	287.0	COG0265@1|root,COG0265@2|Bacteria,2GJ92@201174|Actinobacteria,2NGJK@228398|Streptacidiphilus	201174|Actinobacteria	O	Colicin V production protein	cvpA	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	Colicin_V,Trypsin_2
TLS2_k127_6902188_7	593907.Celgi_0376	2.71e-28	123.0	2C4MW@1|root,32RKK@2|Bacteria,2IQ6A@201174|Actinobacteria,4F1EM@85016|Cellulomonadaceae	201174|Actinobacteria	S	Lsr2	lsr	-	-	-	-	-	-	-	-	-	-	-	Lsr2
TLS2_k127_6902188_6	351607.Acel_0217	5.236e-72	246.0	COG1246@1|root,COG1246@2|Bacteria,2GJBT@201174|Actinobacteria,4ESNZ@85013|Frankiales	201174|Actinobacteria	E	Acetyltransferase (GNAT) domain	argA	GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
TLS2_k127_6902188_0	479433.Caci_8377	2.338e-232	735.0	COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DUF2156,tRNA-synt_2,tRNA-synt_2_TM,tRNA_anti-codon
TLS2_k127_6902188_2	1157637.KB892101_gene2453	6.407e-115	375.0	COG1521@1|root,COG1521@2|Bacteria,2GMRQ@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
TLS2_k127_6902188_3	105420.BBPO01000015_gene5066	3.517e-106	364.0	COG0157@1|root,COG0157@2|Bacteria,2I2IP@201174|Actinobacteria,2NEVS@228398|Streptacidiphilus	201174|Actinobacteria	H	Quinolinate phosphoribosyl transferase, C-terminal domain	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
TLS2_k127_6902188_1	1306174.JODP01000006_gene3431	2.661e-217	699.0	COG0029@1|root,COG0029@2|Bacteria,2I2IJ@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_6902188_5	67257.JODR01000009_gene119	9.98e-90	317.0	COG0414@1|root,COG0414@2|Bacteria,2GJEQ@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
TLS2_k127_6902188_4	1288079.AUKN01000019_gene2727	3.219e-104	345.0	COG5495@1|root,COG5495@2|Bacteria,2I2F6@201174|Actinobacteria	201174|Actinobacteria	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
TLS2_k127_6909998_5	1298863.AUEP01000012_gene3796	2.522e-13	73.0	COG0492@1|root,COG0492@2|Bacteria,2GJ1Z@201174|Actinobacteria,4DT70@85009|Propionibacteriales	201174|Actinobacteria	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.2,1.19.1.1	ko:K21567	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_6909998_6	1464048.JNZS01000074_gene4724	9.522e-06	52.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4D8SX@85008|Micromonosporales	201174|Actinobacteria	V	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_6909998_4	1464048.JNZS01000004_gene1571	5.292e-19	93.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4D8SX@85008|Micromonosporales	201174|Actinobacteria	V	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_6909998_1	1122138.AQUZ01000019_gene8185	1.283e-93	323.0	COG2267@1|root,COG2267@2|Bacteria,2GJUE@201174|Actinobacteria,4DQUJ@85009|Propionibacteriales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_6909998_2	1172179.AUKV01000004_gene6376	1.144e-32	129.0	2E4G6@1|root,32ZBB@2|Bacteria,2GR6E@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6909998_0	436229.JOEH01000021_gene7652	1.612e-111	364.0	COG1018@1|root,COG1018@2|Bacteria,2I3N3@201174|Actinobacteria	201174|Actinobacteria	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	3-alpha,FAD_binding_6,Fer2,MOSC,NAD_binding_1
TLS2_k127_6909998_3	68170.KL590535_gene3889	1.879e-21	93.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4E2YC@85010|Pseudonocardiales	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
TLS2_k127_6948166_6	1380370.JIBA01000016_gene728	7.986e-40	154.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4FETX@85021|Intrasporangiaceae	201174|Actinobacteria	C	Xanthine dehydrogenase	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_6948166_5	479433.Caci_1872	4.577e-74	258.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase small subunit CoxS	-	-	1.2.5.3,1.5.99.14	ko:K03518,ko:K19186	ko00760,ko01120,map00760,map01120	M00810	R07514,R11168	RC01860,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_6948166_4	1123320.KB889640_gene4456	2.333e-102	340.0	COG1319@1|root,COG1319@2|Bacteria,2GP37@201174|Actinobacteria	201174|Actinobacteria	C	Molybdopterin dehydrogenase	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_6948166_0	1386089.N865_03215	7.68e-221	696.0	COG2233@1|root,COG2233@2|Bacteria,2GMH6@201174|Actinobacteria,4FEI2@85021|Intrasporangiaceae	201174|Actinobacteria	F	Nitrate reductase	rutG	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
TLS2_k127_6948166_2	1123320.KB889640_gene4454	1.14e-190	610.0	COG2508@1|root,COG2508@2|Bacteria,2GM1G@201174|Actinobacteria	201174|Actinobacteria	QT	transcriptional regulator	-	-	-	ko:K09684	-	-	-	-	ko00000,ko03000	-	-	-	HTH_30,PucR
TLS2_k127_6948166_7	1122611.KB903941_gene2233	1.367e-27	124.0	2EIHP@1|root,33C91@2|Bacteria,2ICMY@201174|Actinobacteria,4EH8I@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF2877)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2877
TLS2_k127_6948166_3	1380370.JIBA01000016_gene722	3.8e-149	488.0	COG0074@1|root,COG0074@2|Bacteria,2GMFI@201174|Actinobacteria,4FF3V@85021|Intrasporangiaceae	201174|Actinobacteria	C	Protein of unknown function (DUF1116)	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,DUF1116,Ligase_CoA
TLS2_k127_6948166_1	1386089.N865_03190	2.261e-204	647.0	COG0074@1|root,COG0074@2|Bacteria,2GMFI@201174|Actinobacteria,4FF3V@85021|Intrasporangiaceae	201174|Actinobacteria	C	Protein of unknown function (DUF1116)	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,DUF1116,Ligase_CoA
TLS2_k127_6950295_2	1120950.KB892747_gene3745	1.478e-107	354.0	COG0264@1|root,COG0264@2|Bacteria,2GK4M@201174|Actinobacteria,4DNDW@85009|Propionibacteriales	201174|Actinobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
TLS2_k127_6950295_1	1385520.N802_19245	5.261e-115	377.0	COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4FE89@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS2_k127_6950295_4	351607.Acel_1539	1.921e-83	283.0	COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4ESC9@85013|Frankiales	201174|Actinobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
TLS2_k127_6950295_3	1211815.CBYP010000038_gene2180	4.268e-93	315.0	COG4589@1|root,COG4589@2|Bacteria,2GNWK@201174|Actinobacteria,4ES47@85013|Frankiales	201174|Actinobacteria	S	Belongs to the CDS family	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TLS2_k127_6950295_0	1298863.AUEP01000016_gene4244	0.0	1313.0	COG3957@1|root,COG3957@2|Bacteria,2GN27@201174|Actinobacteria,4DNF9@85009|Propionibacteriales	201174|Actinobacteria	G	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
TLS2_k127_6950295_5	1120936.KB907226_gene2855	3.826e-31	124.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4EID1@85012|Streptosporangiales	201174|Actinobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
TLS2_k127_6969740_24	397278.JOJN01000001_gene2978	5.853e-28	113.0	COG0018@1|root,COG0018@2|Bacteria,2GKQ3@201174|Actinobacteria,4DPKA@85009|Propionibacteriales	201174|Actinobacteria	J	Arginyl tRNA synthetase N terminal dom	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
TLS2_k127_6969740_4	1120950.KB892745_gene2859	1.092e-204	649.0	COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria,4DPUN@85009|Propionibacteriales	201174|Actinobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS2_k127_6969740_30	146922.JOFU01000033_gene5817	5.293e-11	64.0	28VMH@1|root,2ZHPN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6969740_5	44060.JODL01000001_gene3093	8.341e-192	608.0	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria	201174|Actinobacteria	E	homoserine dehydrogenase	hom	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294	ACT,Homoserine_dh,NAD_binding_3
TLS2_k127_6969740_9	500153.JOEK01000002_gene314	6.185e-150	499.0	COG0498@1|root,COG0498@2|Bacteria,2GJ5F@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_6969740_14	1449355.JQNR01000005_gene4421	2.97e-91	314.0	COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_6969740_2	1120950.KB892745_gene2863	4.29e-232	734.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4DN0N@85009|Propionibacteriales	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
TLS2_k127_6969740_22	1394178.AWOO02000022_gene7216	2.117e-33	141.0	COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4EK8U@85012|Streptosporangiales	201174|Actinobacteria	J	Binds the 23S rRNA	rpmE	GO:0008150,GO:0040007	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
TLS2_k127_6969740_8	500153.JOEK01000002_gene307	5.09e-159	520.0	COG0216@1|root,COG0216@2|Bacteria,2GJWG@201174|Actinobacteria	201174|Actinobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	GO:0008150,GO:0040007	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS2_k127_6969740_12	1120950.KB892745_gene2866	3.613e-96	322.0	COG2890@1|root,COG2890@2|Bacteria,2GMH1@201174|Actinobacteria,4DP23@85009|Propionibacteriales	201174|Actinobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_25,Methyltransf_31
TLS2_k127_6969740_16	1048339.KB913029_gene3386	1.694e-78	278.0	COG0009@1|root,COG0009@2|Bacteria,2GK2X@201174|Actinobacteria,4ESEK@85013|Frankiales	201174|Actinobacteria	J	Belongs to the SUA5 family	ywlC	GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
TLS2_k127_6969740_20	1380346.JNIH01000045_gene4807	1.769e-48	184.0	COG0394@1|root,COG0394@2|Bacteria,2GMPR@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	etp	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS2_k127_6969740_3	656024.FsymDg_3853	2.558e-218	683.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria,4ERC5@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TLS2_k127_6969740_11	479435.Kfla_5055	9.017e-123	405.0	COG0472@1|root,COG0472@2|Bacteria,2GIT7@201174|Actinobacteria,4DPQZ@85009|Propionibacteriales	201174|Actinobacteria	M	Glycosyl transferase family 4	rfe	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
TLS2_k127_6969740_29	211114.JOEF01000005_gene2173	7.587e-12	74.0	2BJAR@1|root,32DKN@2|Bacteria,2GR4T@201174|Actinobacteria,4E6W8@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6969740_31	446462.Amir_6143	4.605e-10	66.0	2972E@1|root,2ZUAS@2|Bacteria,2HP4B@201174|Actinobacteria,4E7PR@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6969740_17	211114.JOEF01000005_gene2175	9.833e-77	268.0	COG0356@1|root,COG0356@2|Bacteria,2H3PR@201174|Actinobacteria,4DYUM@85010|Pseudonocardiales	201174|Actinobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
TLS2_k127_6969740_26	1504319.GM45_6080	1.756e-24	116.0	COG0636@1|root,COG0636@2|Bacteria,2HGDC@201174|Actinobacteria,3UWZI@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_C
TLS2_k127_6969740_21	1122933.JNIY01000004_gene2542	2.093e-34	143.0	COG0711@1|root,COG0711@2|Bacteria,2GJS4@201174|Actinobacteria,4F167@85016|Cellulomonadaceae	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
TLS2_k127_6969740_19	1123320.KB889571_gene5471	6.185e-60	221.0	COG0712@1|root,COG0712@2|Bacteria,2GMJ5@201174|Actinobacteria	201174|Actinobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02109,ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
TLS2_k127_6969740_0	471852.Tcur_3918	1.68e-271	847.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4EG2U@85012|Streptosporangiales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
TLS2_k127_6969740_13	1048339.KB913029_gene3397	1.561e-92	314.0	COG0224@1|root,COG0224@2|Bacteria,2GJ7Q@201174|Actinobacteria,4ERNM@85013|Frankiales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
TLS2_k127_6969740_1	471852.Tcur_3916	1.085e-244	765.0	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4EG3U@85012|Streptosporangiales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS2_k127_6969740_23	1463885.KL578363_gene1757	5.844e-33	142.0	COG0355@1|root,COG0355@2|Bacteria,2IHNZ@201174|Actinobacteria	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
TLS2_k127_6969740_25	1120950.KB892745_gene2881	1.13e-26	114.0	2E6YX@1|root,331I5@2|Bacteria,2IFIG@201174|Actinobacteria,4DRJC@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF2550)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2550
TLS2_k127_6969740_18	436229.JOEH01000016_gene7074	1.308e-74	280.0	COG2096@1|root,COG2096@2|Bacteria,2GMHN@201174|Actinobacteria,2NEWI@228398|Streptacidiphilus	201174|Actinobacteria	S	Cobalamin adenosyltransferase	yvqK	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
TLS2_k127_6969740_6	1120950.KB892745_gene2885	6.103e-174	566.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4DND6@85009|Propionibacteriales	201174|Actinobacteria	M	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)	murA	GO:0008150,GO:0040007	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TLS2_k127_6969740_15	1206725.BAFU01000053_gene1837	1.764e-79	295.0	COG0671@1|root,COG0671@2|Bacteria,2IAXK@201174|Actinobacteria,4FWWC@85025|Nocardiaceae	201174|Actinobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
TLS2_k127_6969740_28	436229.JOEH01000016_gene7072	4.354e-13	81.0	2E3JG@1|root,32YHV@2|Bacteria,2GU6T@201174|Actinobacteria,2NJVF@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6969740_10	436229.JOEH01000016_gene7071	9.62e-128	414.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,2NGG9@228398|Streptacidiphilus	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	hbd	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_6969740_27	465541.ATCJ01000005_gene5400	2.013e-21	96.0	COG1366@1|root,COG1366@2|Bacteria,2IKUF@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
TLS2_k127_6969740_7	1449355.JQNR01000004_gene1846	9.607e-162	520.0	COG4191@1|root,COG4191@2|Bacteria,2GMRD@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,cNMP_binding
TLS2_k127_6977976_10	1068978.AMETH_1031	1.014e-07	55.0	2CT9V@1|root,32SSX@2|Bacteria,2GKR6@201174|Actinobacteria,4E4EE@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
TLS2_k127_6977976_7	1123023.JIAI01000003_gene2778	1.21e-74	268.0	29B69@1|root,2ZY4N@2|Bacteria,2GKQW@201174|Actinobacteria,4E1ID@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF4350
TLS2_k127_6977976_3	1116232.AHBF01000119_gene4278	2.286e-155	499.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria	201174|Actinobacteria	S	associated with various cellular activities	moxR2	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_6977976_2	1123023.JIAI01000003_gene2776	2.163e-165	552.0	COG1721@1|root,COG1721@2|Bacteria,2GK9A@201174|Actinobacteria,4DXK9@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF58
TLS2_k127_6977976_4	1157637.KB892102_gene1235	1.184e-129	451.0	COG1300@1|root,COG1300@2|Bacteria,2GJTG@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
TLS2_k127_6977976_8	1120950.KB892832_gene4020	2.668e-68	243.0	COG1714@1|root,COG1714@2|Bacteria,2H4MP@201174|Actinobacteria,4DR7H@85009|Propionibacteriales	201174|Actinobacteria	A	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS2_k127_6977976_0	269800.Tfu_2505	2.606e-263	818.0	COG0499@1|root,COG0499@2|Bacteria,2GK2Q@201174|Actinobacteria,4EIAX@85012|Streptosporangiales	201174|Actinobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0000098,GO:0000166,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009087,GO:0009116,GO:0009119,GO:0009987,GO:0016020,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0019899,GO:0022610,GO:0030260,GO:0030312,GO:0033353,GO:0034641,GO:0035375,GO:0035635,GO:0036094,GO:0040007,GO:0042278,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044650,GO:0046085,GO:0046128,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055086,GO:0070403,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS2_k127_6977976_5	219305.MCAG_03970	5.36e-128	417.0	COG0053@1|root,COG0053@2|Bacteria,2GKSG@201174|Actinobacteria,4DAPD@85008|Micromonosporales	201174|Actinobacteria	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TLS2_k127_6977976_6	1048339.KB913029_gene4643	1e-96	337.0	COG1737@1|root,COG1737@2|Bacteria,2GMG0@201174|Actinobacteria,4ESQ5@85013|Frankiales	201174|Actinobacteria	K	Sugar isomerase (SIS)	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	bact-PGI_C
TLS2_k127_6977976_9	1120950.KB892759_gene6292	1.051e-23	101.0	COG2835@1|root,COG2835@2|Bacteria,2HUT7@201174|Actinobacteria,4DSPV@85009|Propionibacteriales	201174|Actinobacteria	S	Trm112p-like protein	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
TLS2_k127_6977976_1	58123.JOFJ01000008_gene400	5.145e-196	620.0	COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,4EGWS@85012|Streptosporangiales	201174|Actinobacteria	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	manB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_700141_7	1240350.AMZE01000057_gene710	2.393e-15	78.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,1RNIM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	transporter	-	-	-	ko:K03762	-	-	-	-	ko00000,ko02000	2.A.1.6.4	-	-	MFS_1,Sugar_tr
TLS2_k127_700141_9	1155718.KB891911_gene1308	3.077e-06	57.0	2EFF7@1|root,33981@2|Bacteria,2IFB2@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_700141_5	1304865.JAGF01000001_gene2443	2.671e-42	161.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	hoxW	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
TLS2_k127_700141_0	1304865.JAGF01000001_gene2442	2.871e-198	639.0	COG3259@1|root,COG3259@2|Bacteria,2GQ33@201174|Actinobacteria	201174|Actinobacteria	C	PFAM Nickel-dependent hydrogenase, large subunit	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
TLS2_k127_700141_2	1304865.JAGF01000001_gene2441	2.066e-139	446.0	COG1941@1|root,COG1941@2|Bacteria,2GSPN@201174|Actinobacteria	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase, 20	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
TLS2_k127_700141_3	1304865.JAGF01000001_gene2440	1.455e-128	417.0	COG0543@1|root,COG0543@2|Bacteria,2HXFY@201174|Actinobacteria	201174|Actinobacteria	CH	Oxidoreductase	asrB	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
TLS2_k127_700141_4	272134.KB731324_gene5861	4.301e-46	170.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	crp	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS2_k127_700141_1	1304865.JAGF01000001_gene2439	1.071e-159	511.0	COG0479@1|root,COG0479@2|Bacteria,2I37A@201174|Actinobacteria	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
TLS2_k127_700141_6	110319.CF8_1918	1.076e-31	131.0	COG3764@1|root,COG3764@2|Bacteria,2IRXZ@201174|Actinobacteria,4DRSR@85009|Propionibacteriales	201174|Actinobacteria	M	PFAM peptidase C60, sortase A and B	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
TLS2_k127_7014317_6	1449347.JQLN01000005_gene5098	1.168e-75	260.0	COG0454@1|root,COG0456@2|Bacteria,2IAC7@201174|Actinobacteria	201174|Actinobacteria	K	Aminoglycoside 2'-N-acetyltransferase	aac	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008080,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016020,GO:0016137,GO:0016139,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017001,GO:0017144,GO:0030647,GO:0030649,GO:0034069,GO:0044237,GO:0044248,GO:0044464,GO:0047921,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658	2.3.1.59	ko:K17840	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_9
TLS2_k127_7014317_2	2045.KR76_15810	1.504e-160	524.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4DPV2@85009|Propionibacteriales	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS2_k127_7014317_4	665577.JH993790_gene2468	7.356e-132	431.0	COG1233@1|root,COG1233@2|Bacteria,2GKRC@201174|Actinobacteria	201174|Actinobacteria	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS2_k127_7014317_12	247156.NFA_31210	5.766e-13	71.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4FWGU@85025|Nocardiaceae	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_7014317_8	1298863.AUEP01000005_gene2629	1.146e-52	194.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4DWJP@85009|Propionibacteriales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_7014317_11	33898.JRHJ01000016_gene4104	1.36e-18	90.0	COG4585@1|root,COG4585@2|Bacteria,2GS7K@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS2_k127_7014317_14	1380347.JNII01000007_gene189	1.522e-06	55.0	2AZ69@1|root,31RD2@2|Bacteria,2ITF8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7014317_3	1121272.KB903249_gene1267	1.156e-155	521.0	COG0654@1|root,COG0654@2|Bacteria,2GJG5@201174|Actinobacteria,4D8UM@85008|Micromonosporales	201174|Actinobacteria	CH	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS2_k127_7014317_7	1429046.RR21198_3744	6.478e-71	249.0	COG1695@1|root,COG1695@2|Bacteria,2IJQK@201174|Actinobacteria,4FZRQ@85025|Nocardiaceae	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_7014317_13	1996.JOFO01000005_gene190	3.083e-11	74.0	2EGSG@1|root,33AIJ@2|Bacteria,2GWW3@201174|Actinobacteria,4EKTJ@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HHH_5
TLS2_k127_7014317_1	1122622.ATWJ01000001_gene2548	1.302e-170	548.0	COG2114@1|root,COG2114@2|Bacteria,2GJRI@201174|Actinobacteria,4FF4J@85021|Intrasporangiaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc
TLS2_k127_7014317_0	1122622.ATWJ01000001_gene2549	1.822e-198	633.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4FF74@85021|Intrasporangiaceae	201174|Actinobacteria	O	Thioredoxin reductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_7014317_9	1449976.KALB_7957	8.359e-36	146.0	COG0454@1|root,COG0456@2|Bacteria,2GY1D@201174|Actinobacteria,4E4N2@85010|Pseudonocardiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_7014317_5	543632.JOJL01000010_gene7218	1.065e-117	388.0	arCOG05230@1|root,33GXI@2|Bacteria,2ICB0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7014317_10	1206725.BAFU01000064_gene320	1.988e-24	103.0	COG2267@1|root,COG2267@2|Bacteria,2I5HD@201174|Actinobacteria,4FZ1V@85025|Nocardiaceae	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_7022703_2	1125971.ASJB01000064_gene6582	8.163e-92	306.0	COG0702@1|root,COG0702@2|Bacteria,2GKXI@201174|Actinobacteria,4E1AD@85010|Pseudonocardiales	201174|Actinobacteria	GM	PFAM NmrA family protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
TLS2_k127_7022703_7	2002.JOEQ01000020_gene7114	8.055e-46	173.0	COG5500@1|root,COG5500@2|Bacteria,2INAA@201174|Actinobacteria,4EKAV@85012|Streptosporangiales	201174|Actinobacteria	S	Domain of unknown function (DUF1772)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1772
TLS2_k127_7022703_3	1120950.KB892779_gene918	4.827e-67	233.0	COG1666@1|root,COG1666@2|Bacteria,2IFIU@201174|Actinobacteria,4DQT9@85009|Propionibacteriales	201174|Actinobacteria	S	Belongs to the UPF0234 family	trpF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
TLS2_k127_7022703_8	1032480.MLP_10510	1.442e-26	111.0	COG0267@1|root,COG0267@2|Bacteria,2GQFG@201174|Actinobacteria,4DS40@85009|Propionibacteriales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
TLS2_k127_7022703_5	1123320.KB889574_gene5594	1.227e-58	214.0	COG2030@1|root,COG2030@2|Bacteria,2GMVC@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the UPF0336 family	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
TLS2_k127_7022703_6	711393.AYRX01000009_gene2367	2.789e-57	208.0	COG2030@1|root,COG2030@2|Bacteria,2IFCJ@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	hadB	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
TLS2_k127_7022703_1	1120950.KB892746_gene3572	1.109e-134	437.0	COG0812@1|root,COG0812@2|Bacteria,2GIV2@201174|Actinobacteria,4DNF7@85009|Propionibacteriales	201174|Actinobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
TLS2_k127_7022703_4	1386089.N865_05305	4.043e-63	226.0	COG0300@1|root,COG0300@2|Bacteria,2HJGE@201174|Actinobacteria,4FGMX@85021|Intrasporangiaceae	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_7022703_0	479435.Kfla_6174	2.519e-155	498.0	COG1816@1|root,COG1816@2|Bacteria,2GKJP@201174|Actinobacteria,4DN6T@85009|Propionibacteriales	201174|Actinobacteria	F	adenosine deaminase	add	GO:0000034,GO:0003674,GO:0003824,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
TLS2_k127_7022703_10	1894.JOER01000089_gene1752	7.517e-06	48.0	COG0673@1|root,COG0673@2|Bacteria,2GN2Z@201174|Actinobacteria	201174|Actinobacteria	S	oxidoreductase	ydgJ	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_7064998_13	219305.MCAG_03605	1.689e-20	95.0	COG1579@1|root,COG1579@2|Bacteria,2I2XU@201174|Actinobacteria,4DD8T@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
TLS2_k127_7064998_4	1134445.AJJM01000026_gene4400	7.704e-152	499.0	COG0407@1|root,COG0407@2|Bacteria,2GMY6@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS2_k127_7064998_10	196162.Noca_3675	1.33e-65	248.0	2AIF4@1|root,318WM@2|Bacteria,2GK8R@201174|Actinobacteria,4DQE6@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF3000)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3000
TLS2_k127_7064998_3	1123320.KB889576_gene1967	2.424e-167	542.0	COG0349@1|root,COG0349@2|Bacteria,2GKNM@201174|Actinobacteria	201174|Actinobacteria	J	3-5 exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
TLS2_k127_7064998_5	479432.Sros_8137	1.54e-151	505.0	COG1232@1|root,COG1232@2|Bacteria,2IDI5@201174|Actinobacteria	201174|Actinobacteria	H	PFAM amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS2_k127_7064998_8	1123023.JIAI01000020_gene2081	4.456e-74	275.0	COG4912@1|root,COG4912@2|Bacteria,2GNQD@201174|Actinobacteria,4E2Z3@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA alkylation repair	alkD	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
TLS2_k127_7064998_2	1306174.JODP01000013_gene7756	6.337e-214	670.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_7064998_0	211114.JOEF01000016_gene3752	3.705e-288	902.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,2GJ50@201174|Actinobacteria,4DZVR@85010|Pseudonocardiales	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadB	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
TLS2_k127_7064998_11	1476876.JOJO01000014_gene7174	2.803e-49	190.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_7064998_1	1123320.KB889685_gene2191	1.793e-278	870.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria	201174|Actinobacteria	HI	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
TLS2_k127_7064998_12	106370.Francci3_0265	4.452e-29	127.0	2FCKD@1|root,344PQ@2|Bacteria,2GVQX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7064998_9	1380356.JNIK01000014_gene3482	8.805e-68	253.0	COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,cNMP_binding
TLS2_k127_7064998_6	196162.Noca_2379	6.009e-117	388.0	COG1940@1|root,COG1940@2|Bacteria,2GPEI@201174|Actinobacteria,4DQQU@85009|Propionibacteriales	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
TLS2_k127_7064998_7	1306174.JODP01000013_gene7762	4.219e-102	338.0	COG4214@1|root,COG4214@2|Bacteria,2GJAH@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10544	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	BPD_transp_2
TLS2_k127_7066385_6	479431.Namu_1568	0.0002817	44.0	COG2374@1|root,COG2374@2|Bacteria,2I2E0@201174|Actinobacteria,4ESXB@85013|Frankiales	201174|Actinobacteria	Q	Endonuclease/Exonuclease/phosphatase family	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Big_3_5,Big_5,CW_binding_2,DUF3616,Exo_endo_phos,LTD
TLS2_k127_7066385_0	1380356.JNIK01000001_gene2102	1.719e-128	431.0	COG3266@1|root,COG3266@2|Bacteria,2I44K@201174|Actinobacteria,4ERQA@85013|Frankiales	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7066385_2	749414.SBI_05728	4.927e-46	183.0	COG3255@1|root,COG3255@2|Bacteria,2IQBF@201174|Actinobacteria	201174|Actinobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
TLS2_k127_7066385_1	446462.Amir_4408	8.242e-47	184.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4DXCK@85010|Pseudonocardiales	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_7066385_3	1206730.BAGA01000184_gene3039	1.418e-13	83.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4FU95@85025|Nocardiaceae	201174|Actinobacteria	M	Glycosyl transferase 4-like	-	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_7066385_5	1122609.AUGT01000010_gene3767	1.376e-05	51.0	2BX0U@1|root,33UUW@2|Bacteria,2INHF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
TLS2_k127_7066385_4	1122609.AUGT01000010_gene3767	7.235e-09	59.0	2BX0U@1|root,33UUW@2|Bacteria,2INHF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
TLS2_k127_7086731_4	1463854.JOHT01000013_gene4171	1.311e-102	342.0	COG1208@1|root,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria	201174|Actinobacteria	JM	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits	manC	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
TLS2_k127_7086731_6	1048339.KB913029_gene2	5.265e-51	190.0	COG3415@1|root,COG3415@2|Bacteria,2HU0Q@201174|Actinobacteria,4EW3N@85013|Frankiales	201174|Actinobacteria	L	Protein of unknown function (DUF3105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3105
TLS2_k127_7086731_3	1120950.KB892759_gene6281	1.165e-107	359.0	COG0122@1|root,COG0122@2|Bacteria,2GP69@201174|Actinobacteria,4DPY4@85009|Propionibacteriales	201174|Actinobacteria	L	3-methyladenine DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7086731_1	570268.ANBB01000052_gene2948	2.648e-164	530.0	COG0778@1|root,COG1478@1|root,COG0778@2|Bacteria,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4EFGM@85012|Streptosporangiales	201174|Actinobacteria	C	F420-0:Gamma-glutamyl ligase	fbiB	GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase,Nitroreductase
TLS2_k127_7086731_2	1306174.JODP01000001_gene4648	1.217e-126	440.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria	201174|Actinobacteria	S	Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP	cofD	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0043743,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
TLS2_k127_7086731_8	1068980.ARVW01000001_gene4562	5.572e-40	153.0	2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,4E5EK@85010|Pseudonocardiales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB2	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS2_k127_7086731_0	1120950.KB892759_gene6286	2.755e-240	784.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,4DN93@85009|Propionibacteriales	201174|Actinobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
TLS2_k127_7086731_5	1120950.KB892759_gene6287	4.738e-59	228.0	COG3147@1|root,COG3147@2|Bacteria,2HC8A@201174|Actinobacteria,4DRQT@85009|Propionibacteriales	201174|Actinobacteria	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7086731_7	1095767.CAHD01000165_gene3018	3.256e-40	160.0	COG3824@1|root,COG3824@2|Bacteria,2IS6W@201174|Actinobacteria,4F2J2@85016|Cellulomonadaceae	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
TLS2_k127_7086731_9	196162.Noca_1424	1.927e-39	155.0	2C7XW@1|root,32RR4@2|Bacteria,2IQ5R@201174|Actinobacteria,4DRSS@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF3499)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3499
TLS2_k127_7106_1	369723.Strop_0264	3.767e-61	234.0	COG1247@1|root,COG1247@2|Bacteria,2I3KT@201174|Actinobacteria,4DMR0@85008|Micromonosporales	201174|Actinobacteria	M	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_7106_0	263358.VAB18032_03185	1.959e-113	370.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,4DBBT@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS2_k127_7108951_11	68170.KL590477_gene2601	6.002e-32	139.0	COG4552@1|root,COG4552@2|Bacteria,2HW68@201174|Actinobacteria,4E1VX@85010|Pseudonocardiales	201174|Actinobacteria	S	Sterol carrier protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
TLS2_k127_7108951_12	1132441.KI519454_gene1718	8.142e-24	110.0	COG5634@1|root,COG5634@2|Bacteria,2GJRH@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2278)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2278,LTD
TLS2_k127_7108951_15	1132441.KI519454_gene1718	7.325e-21	99.0	COG5634@1|root,COG5634@2|Bacteria,2GJRH@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2278)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2278,LTD
TLS2_k127_7108951_7	1240349.ANGC01000089_gene3320	5.267e-64	222.0	COG2764@1|root,COG2764@2|Bacteria,2IKY5@201174|Actinobacteria,4G1QC@85025|Nocardiaceae	201174|Actinobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt,Glyoxalase
TLS2_k127_7108951_6	1487953.JMKF01000045_gene2923	2.858e-66	232.0	COG4430@1|root,COG4430@2|Bacteria,1G2ES@1117|Cyanobacteria,1HBP2@1150|Oscillatoriales	1117|Cyanobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
TLS2_k127_7108951_9	525909.Afer_0033	1.005e-44	171.0	COG1396@1|root,COG1669@1|root,COG1396@2|Bacteria,COG1669@2|Bacteria,2HGH2@201174|Actinobacteria,4CNEF@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
TLS2_k127_7108951_10	882083.SacmaDRAFT_1892	9.778e-35	138.0	COG2361@1|root,COG2361@2|Bacteria,2GUED@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
TLS2_k127_7108951_5	1312954.KI914868_gene121	2.677e-94	316.0	COG1277@1|root,COG1277@2|Bacteria,2GP6D@201174|Actinobacteria,1WB69@1268|Micrococcaceae	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
TLS2_k127_7108951_4	1150398.JIBJ01000002_gene1150	3.997e-116	399.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,1WCH5@1268|Micrococcaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_7108951_8	710696.Intca_0833	9.201e-49	190.0	COG2834@1|root,COG2834@2|Bacteria,2GKA2@201174|Actinobacteria,4FJFY@85021|Intrasporangiaceae	201174|Actinobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092,MucB_RseB
TLS2_k127_7108951_1	1304865.JAGF01000001_gene3256	3.656e-184	593.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinP	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
TLS2_k127_7108951_14	1122622.ATWJ01000013_gene76	1.103e-22	111.0	COG2197@1|root,COG2197@2|Bacteria,2GN29@201174|Actinobacteria,4FEQW@85021|Intrasporangiaceae	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_7108951_17	1120949.KB903358_gene5089	1.402e-08	61.0	COG2197@1|root,COG2197@2|Bacteria,2GN29@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_7108951_16	446471.Xcel_1460	3.871e-12	69.0	COG2197@1|root,COG2197@2|Bacteria,2GN29@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_7108951_2	1312954.KI914858_gene965	4.761e-173	558.0	COG4191@1|root,COG4191@2|Bacteria,2GMRD@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,cNMP_binding
TLS2_k127_7108951_13	1169161.KB897745_gene2791	5.449e-23	108.0	COG1610@1|root,COG1610@2|Bacteria,2GQVP@201174|Actinobacteria	201174|Actinobacteria	S	YqeY-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS2_k127_7108951_0	1122182.KB903839_gene1102	5.014e-294	925.0	COG1404@1|root,COG2133@1|root,COG3291@1|root,COG1404@2|Bacteria,COG2133@2|Bacteria,COG3291@2|Bacteria,2GJFY@201174|Actinobacteria,4DASA@85008|Micromonosporales	201174|Actinobacteria	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CarboxypepD_reg,F5_F8_type_C,GSDH,PA14,PKD
TLS2_k127_7108951_3	369723.Strop_2970	4.847e-120	391.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4DBTB@85008|Micromonosporales	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_7113530_9	40571.JOEA01000032_gene710	2.564e-19	101.0	2CT9V@1|root,32SSX@2|Bacteria,2GKR6@201174|Actinobacteria,4E4EE@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
TLS2_k127_7113530_5	67275.JOAP01000039_gene3359	7.808e-67	246.0	COG4223@1|root,COG4223@2|Bacteria,2I390@201174|Actinobacteria	201174|Actinobacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	GPDPase_memb
TLS2_k127_7113530_2	1289387.AUKW01000024_gene2945	1.384e-120	398.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator receiver	mtrA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016310,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K07670	ko02020,map02020	M00461	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_7113530_0	1123320.KB889749_gene4536	9.679e-181	584.0	COG5002@1|root,COG5002@2|Bacteria,2GJ2D@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	mtrB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.7.13.3	ko:K07636,ko:K07654	ko02020,map02020	M00434,M00461	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_7113530_3	1120950.KB892764_gene5596	1.469e-80	291.0	COG5401@1|root,COG5401@2|Bacteria,2GJ5Y@201174|Actinobacteria,4DQ1Z@85009|Propionibacteriales	201174|Actinobacteria	M	Sporulation and spore germination	lpqB	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Germane,Gmad1
TLS2_k127_7113530_6	1463855.JOHV01000005_gene2751	1.878e-46	177.0	COG1040@1|root,COG1040@2|Bacteria,2I9PA@201174|Actinobacteria	201174|Actinobacteria	S	phosphoribosyltransferase	pyrE_1	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
TLS2_k127_7113530_4	110319.CF8_1195	3.571e-75	261.0	COG1544@1|root,COG1544@2|Bacteria,2GMYF@201174|Actinobacteria,4DQCT@85009|Propionibacteriales	201174|Actinobacteria	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
TLS2_k127_7113530_10	1120949.KB903294_gene3854	9.693e-18	87.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4DA5Z@85008|Micromonosporales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_7113530_7	561175.KB894093_gene3072	3.237e-46	172.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria,4EIFM@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
TLS2_k127_7113530_1	1120950.KB892764_gene5600	2.543e-169	541.0	COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria,4DN5U@85009|Propionibacteriales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
TLS2_k127_7113530_8	1120950.KB892764_gene5601	5.885e-25	107.0	COG1670@1|root,COG1670@2|Bacteria,2GMDB@201174|Actinobacteria,4DQEE@85009|Propionibacteriales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_7143493_10	1370125.AUWT01000052_gene4889	9.277e-05	45.0	COG0433@1|root,COG0433@2|Bacteria,2GM12@201174|Actinobacteria,236SN@1762|Mycobacteriaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
TLS2_k127_7143493_3	1193181.BN10_300014	1.627e-147	484.0	COG2234@1|root,COG2234@2|Bacteria,2IDP0@201174|Actinobacteria,4FE57@85021|Intrasporangiaceae	201174|Actinobacteria	S	PA domain	-	-	3.4.17.21	ko:K01301	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28
TLS2_k127_7143493_1	44060.JODL01000011_gene1970	6.134e-186	607.0	COG2812@1|root,COG2812@2|Bacteria,2GJKA@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
TLS2_k127_7143493_8	235985.BBPN01000032_gene231	1.497e-31	127.0	COG0718@1|root,COG0718@2|Bacteria,2IRC4@201174|Actinobacteria,2NJ2S@228398|Streptacidiphilus	201174|Actinobacteria	S	YbaB/EbfC DNA-binding family	ybaB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
TLS2_k127_7143493_4	1449355.JQNR01000005_gene2776	2.642e-118	383.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria	201174|Actinobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
TLS2_k127_7143493_6	351607.Acel_2014	2.246e-64	226.0	299JI@1|root,2ZWN1@2|Bacteria,2GMZP@201174|Actinobacteria,4EVHT@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF5063)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5063
TLS2_k127_7143493_0	471852.Tcur_4886	3.565e-215	674.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4EG8Z@85012|Streptosporangiales	201174|Actinobacteria	E	ACT domain	ask	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
TLS2_k127_7143493_2	1123322.KB904668_gene3747	1.726e-180	571.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_7143493_7	269800.Tfu_0108	7.175e-46	173.0	COG1610@1|root,COG1610@2|Bacteria,2IFFJ@201174|Actinobacteria	201174|Actinobacteria	S	GatB YqeY	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS2_k127_7143493_5	196162.Noca_0324	1.909e-116	382.0	COG1408@1|root,COG1408@2|Bacteria,2GJHT@201174|Actinobacteria,4DNBM@85009|Propionibacteriales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	ykuE	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
TLS2_k127_7143493_9	436229.JOEH01000009_gene4564	2.63e-09	61.0	COG1609@1|root,COG1609@2|Bacteria,2GSWK@201174|Actinobacteria,2NJKA@228398|Streptacidiphilus	201174|Actinobacteria	K	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Phage_int_SAM_3,Phage_integrase
TLS2_k127_7155492_4	1240349.ANGC01000054_gene4180	3.225e-59	207.0	COG3957@1|root,COG3957@2|Bacteria,2GN27@201174|Actinobacteria,4FVHE@85025|Nocardiaceae	201174|Actinobacteria	G	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
TLS2_k127_7155492_2	471852.Tcur_3404	6.612e-184	581.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4EID1@85012|Streptosporangiales	201174|Actinobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
TLS2_k127_7155492_7	1454010.JEOE01000029_gene3046	6.104e-09	68.0	2DSFM@1|root,33FYJ@2|Bacteria,2I6ZI@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7155492_6	457425.XNR_4575	8.56e-42	168.0	COG0346@1|root,COG0346@2|Bacteria,2IM0I@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,Glyoxalase_4
TLS2_k127_7155492_0	443218.AS9A_0822	3.276e-309	959.0	COG0365@1|root,COG0365@2|Bacteria,2GP7N@201174|Actinobacteria,23529@1762|Mycobacteriaceae	201174|Actinobacteria	I	PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_7155492_5	1206730.BAGA01000074_gene1724	2.142e-54	195.0	COG2867@1|root,COG2867@2|Bacteria,2H4BU@201174|Actinobacteria,4G1RF@85025|Nocardiaceae	201174|Actinobacteria	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_7155492_3	1429046.RR21198_5619	2.339e-154	500.0	COG1020@1|root,COG1020@2|Bacteria,2IGNH@201174|Actinobacteria,4G6IZ@85025|Nocardiaceae	201174|Actinobacteria	I	Protein of unknown function (DUF1298)	-	-	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
TLS2_k127_7155492_1	1123320.KB889675_gene4065	2.514e-193	613.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS2_k127_7159012_1	1386089.N865_13005	5.135e-63	229.0	COG3832@1|root,COG3832@2|Bacteria,2IFGN@201174|Actinobacteria,4FH38@85021|Intrasporangiaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_7159012_2	298655.KI912266_gene557	1.512e-49	188.0	COG0640@1|root,COG0640@2|Bacteria,2IKWF@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_7159012_0	298655.KI912266_gene556	5.823e-83	276.0	COG3832@1|root,COG3832@2|Bacteria,2IHN6@201174|Actinobacteria	201174|Actinobacteria	S	Activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_7159012_3	1463825.JNXC01000043_gene7454	7.859e-47	183.0	COG2304@1|root,COG2304@2|Bacteria,2GUB3@201174|Actinobacteria,4E1CP@85010|Pseudonocardiales	201174|Actinobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11,VWA
TLS2_k127_71680_0	1003195.SCAT_2418	3.322e-217	705.0	COG3225@1|root,COG3225@2|Bacteria,2GMTX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_71680_10	110319.CF8_0658	4.937e-23	101.0	2ETMT@1|root,33M5J@2|Bacteria,2IQ41@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2530)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2530
TLS2_k127_71680_9	1120950.KB892775_gene1200	4.704e-42	162.0	COG1846@1|root,COG1846@2|Bacteria,2IFQ9@201174|Actinobacteria,4DS13@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_71680_3	1120950.KB892775_gene1201	1.015e-144	477.0	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria,4DWFF@85009|Propionibacteriales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_71680_8	33876.JNXY01000035_gene679	1.911e-43	172.0	COG3154@1|root,COG3154@2|Bacteria,2INVN@201174|Actinobacteria,4DE1S@85008|Micromonosporales	201174|Actinobacteria	I	MDMPI C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
TLS2_k127_71680_7	1123023.JIAI01000009_gene1218	4.26e-47	177.0	COG1514@1|root,COG1514@2|Bacteria,2GNDN@201174|Actinobacteria	201174|Actinobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
TLS2_k127_71680_4	1120950.KB892775_gene1212	4.954e-143	471.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4DPHB@85009|Propionibacteriales	201174|Actinobacteria	C	Aldo/keto reductase family	eryBII	-	-	ko:K13315	ko00523,ko01130,map00523,map01130	M00798,M00799	R11051,R11474	RC00897,RC01516	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldo_ket_red
TLS2_k127_71680_5	1120950.KB892720_gene1922	7.228e-140	460.0	COG2890@1|root,COG2890@2|Bacteria,2I3KM@201174|Actinobacteria,4DNZ4@85009|Propionibacteriales	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_32
TLS2_k127_71680_2	1380370.JIBA01000019_gene965	2.261e-180	571.0	COG1932@1|root,COG1932@2|Bacteria,2GKYK@201174|Actinobacteria,4FEJI@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TLS2_k127_71680_1	66874.JOFS01000021_gene5905	1.933e-198	622.0	COG0372@1|root,COG0372@2|Bacteria,2GKST@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the citrate synthase family	citA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS2_k127_71680_6	1120950.KB892720_gene1916	4.737e-78	267.0	COG0259@1|root,COG0789@1|root,COG0259@2|Bacteria,COG0789@2|Bacteria,2GJCR@201174|Actinobacteria,4DQT7@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0010181,GO:0016491,GO:0016614,GO:0016899,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032553,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042803,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2607	PNP_phzG_C,Putative_PNPOx
TLS2_k127_7174606_1	1095767.CAHD01000213_gene585	3.87e-221	694.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4F0EX@85016|Cellulomonadaceae	201174|Actinobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TLS2_k127_7174606_2	1394178.AWOO02000020_gene7487	1.367e-143	471.0	COG0176@1|root,COG0176@2|Bacteria,2GMF9@201174|Actinobacteria,4EI6P@85012|Streptosporangiales	201174|Actinobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TLS2_k127_7174606_0	479435.Kfla_3272	0.0	1031.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4DN1Y@85009|Propionibacteriales	201174|Actinobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TLS2_k127_7174606_3	1122622.ATWJ01000010_gene1346	5.712e-99	360.0	COG0109@1|root,COG0109@2|Bacteria,2GJMY@201174|Actinobacteria,4FEY1@85021|Intrasporangiaceae	201174|Actinobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
TLS2_k127_7174606_5	500153.JOEK01000014_gene5636	2.923e-10	72.0	2ER41@1|root,33IPK@2|Bacteria,2IKQ6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7174606_4	1120950.KB892707_gene4644	6.164e-90	305.0	COG1612@1|root,COG1612@2|Bacteria,2GJQX@201174|Actinobacteria,4DQ6X@85009|Propionibacteriales	201174|Actinobacteria	O	cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
TLS2_k127_7208608_2	1304275.C41B8_17601	5.052e-09	59.0	2CEID@1|root,34BIU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7208608_0	1463887.KL590024_gene1493	1.406e-97	328.0	COG1131@1|root,COG1131@2|Bacteria,2I2I7@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_7208608_1	1449346.JQMO01000003_gene5278	7.094e-52	189.0	COG0842@1|root,COG0842@2|Bacteria,2GJ7Y@201174|Actinobacteria,2M1CI@2063|Kitasatospora	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01990,ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_7212763_9	196162.Noca_4928	5.006e-20	91.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2IDNX@201174|Actinobacteria,4DTRZ@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD
TLS2_k127_7212763_8	926550.CLDAP_11630	4.4e-29	129.0	COG2452@1|root,COG4936@1|root,COG2452@2|Bacteria,COG4936@2|Bacteria	2|Bacteria	KT	Sensory domain found in PocR	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HTH_17,PocR
TLS2_k127_7212763_1	1385519.N801_12760	6.642e-197	632.0	COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria,4FFV5@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DsrC,Pyr_redox_2
TLS2_k127_7212763_7	926550.CLDAP_11610	2.91e-34	141.0	COG2427@1|root,COG2427@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1641
TLS2_k127_7212763_6	1304865.JAGF01000001_gene3098	1.17e-44	168.0	COG2920@1|root,COG2920@2|Bacteria,2IQB2@201174|Actinobacteria	201174|Actinobacteria	P	PFAM DsrC family protein	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
TLS2_k127_7212763_3	1304865.JAGF01000001_gene3097	1.299e-70	248.0	COG2210@1|root,COG2210@2|Bacteria,2IFXH@201174|Actinobacteria	201174|Actinobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
TLS2_k127_7212763_4	1032480.MLP_02910	3.259e-69	245.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS2_k127_7212763_2	365528.KB891209_gene2184	3.639e-116	386.0	COG2519@1|root,COG2519@2|Bacteria,2GMKZ@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_7212763_0	365528.KB891209_gene2183	1.485e-224	730.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
TLS2_k127_7212763_5	2045.KR76_08315	4.968e-48	176.0	COG2378@1|root,COG2378@2|Bacteria,2IMC4@201174|Actinobacteria,4DRG9@85009|Propionibacteriales	201174|Actinobacteria	K	WYL domain	-	-	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
TLS2_k127_7213194_2	1298863.AUEP01000001_gene784	1.548e-48	199.0	COG4585@1|root,COG4585@2|Bacteria,2H3U9@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7213194_0	1298863.AUEP01000001_gene785	1.584e-134	452.0	COG4585@1|root,COG4585@2|Bacteria,2GMMU@201174|Actinobacteria,4DV3H@85009|Propionibacteriales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_7213194_1	1298863.AUEP01000001_gene786	2.001e-68	235.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4DNEX@85009|Propionibacteriales	201174|Actinobacteria	V	COG1136 ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_7293477_10	512565.AMIS_72940	6.655e-15	76.0	COG3677@1|root,COG3677@2|Bacteria	2|Bacteria	L	transposition, DNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7293477_7	66875.JODY01000003_gene3459	6.32e-100	334.0	COG0175@1|root,COG0175@2|Bacteria,2GJ3Z@201174|Actinobacteria	201174|Actinobacteria	EH	Belongs to the PAPS reductase family. CysH subfamily	cysH	GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TLS2_k127_7293477_9	414996.IL38_07290	3.735e-50	196.0	COG0529@1|root,COG0529@2|Bacteria,2GMUK@201174|Actinobacteria,408ZV@622450|Actinopolysporales	201174|Actinobacteria	P	Adenylylsulphate kinase	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
TLS2_k127_7293477_3	1304865.JAGF01000001_gene2030	3.26e-154	507.0	COG0175@1|root,COG0175@2|Bacteria,2GN85@201174|Actinobacteria,4F1WB@85016|Cellulomonadaceae	201174|Actinobacteria	EH	TIGRFAM sulfate adenylyltransferase, small subunit	cysD	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TLS2_k127_7293477_2	1304865.JAGF01000001_gene2029	5.593e-184	592.0	COG2895@1|root,COG2895@2|Bacteria,2GJDX@201174|Actinobacteria,4F27K@85016|Cellulomonadaceae	201174|Actinobacteria	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysN	-	2.7.7.4	ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_EFTU
TLS2_k127_7293477_5	1380356.JNIK01000011_gene1599	4.832e-141	457.0	COG0715@1|root,COG0715@2|Bacteria,2GK7X@201174|Actinobacteria,4ERKM@85013|Frankiales	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
TLS2_k127_7293477_8	284031.JNXD01000027_gene1454	3.627e-75	265.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria	201174|Actinobacteria	P	ABC transporter	ssuB	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TLS2_k127_7293477_6	1380347.JNII01000009_gene2027	1.132e-127	415.0	COG0600@1|root,COG0600@2|Bacteria,2GIWG@201174|Actinobacteria,4EUUR@85013|Frankiales	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	ssuC3	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TLS2_k127_7293477_4	590998.Celf_2118	2.356e-150	499.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,2GK3B@201174|Actinobacteria,4F0HX@85016|Cellulomonadaceae	201174|Actinobacteria	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	cysG	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,TP_methylase
TLS2_k127_7293477_0	1713.JOFV01000014_gene879	1.124e-223	705.0	COG0402@1|root,COG0402@2|Bacteria,2IB7M@201174|Actinobacteria,4F1V1@85016|Cellulomonadaceae	201174|Actinobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_7293477_1	1713.JOFV01000014_gene880	1.593e-197	635.0	COG0793@1|root,COG0793@2|Bacteria,2HFZM@201174|Actinobacteria,4F1XU@85016|Cellulomonadaceae	201174|Actinobacteria	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
TLS2_k127_7439231_4	1173024.KI912152_gene385	1.029e-31	135.0	COG4803@1|root,COG4803@2|Bacteria,1GB61@1117|Cyanobacteria	1117|Cyanobacteria	S	membrane protein of uknown function UCP014873	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7439231_2	1341646.CBMO010000047_gene3728	1.713e-76	282.0	2D3F0@1|root,32TEU@2|Bacteria,2IDGD@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7439231_0	518766.Rmar_1647	4.447e-176	574.0	COG1757@1|root,COG1757@2|Bacteria,4NHP9@976|Bacteroidetes,1FIXG@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
TLS2_k127_7439231_1	1238182.C882_0316	9.98e-113	409.0	COG2114@1|root,COG2267@1|root,COG3629@1|root,COG3899@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,2JQNY@204441|Rhodospirillales	204441|Rhodospirillales	T	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,SAM_1
TLS2_k127_7439231_3	1394178.AWOO02000017_gene6680	4.558e-43	183.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4EHSW@85012|Streptosporangiales	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,NB-ARC,TPR_12,Trans_reg_C
TLS2_k127_7442010_0	1122622.ATWJ01000007_gene1450	0.0	1193.0	COG0366@1|root,COG1523@1|root,COG0366@2|Bacteria,COG1523@2|Bacteria,2GKK1@201174|Actinobacteria,4FEA5@85021|Intrasporangiaceae	201174|Actinobacteria	G	Alpha-amylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Alpha-amylase_C,CBM_48,DUF3372
TLS2_k127_7442010_1	1122138.AQUZ01000015_gene6722	6.499e-283	877.0	COG0488@1|root,COG0488@2|Bacteria,2GMUD@201174|Actinobacteria,4DNQ6@85009|Propionibacteriales	201174|Actinobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS2_k127_7442010_3	471853.Bcav_3109	2.323e-113	375.0	COG0101@1|root,COG0101@2|Bacteria,2GJ6C@201174|Actinobacteria	201174|Actinobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
TLS2_k127_7442010_5	67257.JODR01000016_gene4747	3.289e-60	217.0	COG0203@1|root,COG0203@2|Bacteria,2IHV2@201174|Actinobacteria	201174|Actinobacteria	J	ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
TLS2_k127_7442010_2	1120950.KB892746_gene3638	8.815e-186	586.0	COG0202@1|root,COG0202@2|Bacteria,2GJJ5@201174|Actinobacteria,4DNW6@85009|Propionibacteriales	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
TLS2_k127_7442010_4	935866.JAER01000028_gene1527	2.082e-99	327.0	COG0522@1|root,COG0522@2|Bacteria,2GIRX@201174|Actinobacteria,4DP75@85009|Propionibacteriales	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
TLS2_k127_7442010_6	33876.JNXY01000022_gene4508	1.538e-42	156.0	COG0100@1|root,COG0100@2|Bacteria,2IFFC@201174|Actinobacteria,4DCRK@85008|Micromonosporales	201174|Actinobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
TLS2_k127_7452708_6	1283283.ATXA01000006_gene1838	3.246e-26	110.0	COG4995@1|root,COG4995@2|Bacteria,2GKCX@201174|Actinobacteria,4ES70@85013|Frankiales	201174|Actinobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
TLS2_k127_7452708_0	1283283.ATXA01000006_gene1838	4.478e-160	536.0	COG4995@1|root,COG4995@2|Bacteria,2GKCX@201174|Actinobacteria,4ES70@85013|Frankiales	201174|Actinobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
TLS2_k127_7452708_2	1032480.MLP_48020	3.105e-47	185.0	COG1321@1|root,COG1321@2|Bacteria,2I42V@201174|Actinobacteria,4DSHK@85009|Propionibacteriales	201174|Actinobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7452708_4	1120950.KB892790_gene2071	1.071e-30	134.0	COG4709@1|root,COG4709@2|Bacteria,2I09C@201174|Actinobacteria,4DWC9@85009|Propionibacteriales	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7452708_3	479434.Sthe_2783	1.807e-38	147.0	COG1695@1|root,COG1695@2|Bacteria,2G7C9@200795|Chloroflexi	200795|Chloroflexi	K	PFAM transcriptional regulator PadR family protein	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
TLS2_k127_7452708_5	1121924.ATWH01000024_gene1052	2.703e-30	125.0	COG1848@1|root,COG1848@2|Bacteria,2GRA5@201174|Actinobacteria,4FSPB@85023|Microbacteriaceae	201174|Actinobacteria	S	PIN domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045926,GO:0048519,GO:0050789,GO:0065007,GO:0071944	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
TLS2_k127_7452708_7	994479.GL877878_gene439	1.695e-13	73.0	COG4118@1|root,COG4118@2|Bacteria,2GZW9@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS2_k127_7452708_1	1123320.KB889748_gene4528	4.542e-133	443.0	COG2378@1|root,COG2378@2|Bacteria,2GURQ@201174|Actinobacteria	201174|Actinobacteria	K	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
TLS2_k127_784497_4	526225.Gobs_3560	2.889e-69	248.0	COG0177@1|root,COG0177@2|Bacteria,2GNE5@201174|Actinobacteria,4ESU7@85013|Frankiales	201174|Actinobacteria	L	PFAM HhH-GPD family protein	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
TLS2_k127_784497_5	479435.Kfla_3427	3.516e-49	181.0	COG0589@1|root,COG0589@2|Bacteria,2IR3G@201174|Actinobacteria,4DRRV@85009|Propionibacteriales	201174|Actinobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_784497_6	446468.Ndas_2805	6.598e-19	89.0	2CC1Y@1|root,32S23@2|Bacteria,2IQS5@201174|Actinobacteria,4EJVT@85012|Streptosporangiales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB3	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS2_k127_784497_3	1211815.CBYP010000063_gene1845	1.145e-107	356.0	COG1752@1|root,COG1752@2|Bacteria,2GNBM@201174|Actinobacteria,4EUCQ@85013|Frankiales	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS2_k127_784497_2	196162.Noca_0015	1.922e-115	389.0	COG0204@1|root,COG0204@2|Bacteria,2I8I4@201174|Actinobacteria,4DTB6@85009|Propionibacteriales	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TLS2_k127_784497_0	649831.L083_5166	2.726e-232	731.0	COG1473@1|root,COG1473@2|Bacteria,2I2WA@201174|Actinobacteria,4DBB4@85008|Micromonosporales	201174|Actinobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
TLS2_k127_784497_1	1048339.KB913029_gene3833	2.708e-169	544.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4ESAZ@85013|Frankiales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
TLS2_k127_797903_4	1246995.AFR_30335	1.732e-138	446.0	COG0451@1|root,COG0451@2|Bacteria,2GP24@201174|Actinobacteria,4DBKK@85008|Micromonosporales	201174|Actinobacteria	GM	GDP-mannose 4,6 dehydratase	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS2_k127_797903_11	1246995.AFR_21890	9.761e-10	65.0	COG2085@1|root,COG2085@2|Bacteria,2I8W4@201174|Actinobacteria	201174|Actinobacteria	S	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
TLS2_k127_797903_8	928724.SacglDRAFT_01599	8.457e-122	404.0	COG0153@1|root,COG0153@2|Bacteria,2GJXI@201174|Actinobacteria,4E015@85010|Pseudonocardiales	201174|Actinobacteria	G	Belongs to the GHMP kinase family. GalK subfamily	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
TLS2_k127_797903_6	1120950.KB892760_gene5745	6.192e-127	429.0	COG1087@1|root,COG1087@2|Bacteria,2GMCW@201174|Actinobacteria,4DQX1@85009|Propionibacteriales	201174|Actinobacteria	M	Polysaccharide biosynthesis protein	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS2_k127_797903_3	1120950.KB892760_gene5746	1.386e-156	505.0	COG1085@1|root,COG1085@2|Bacteria,2I2DM@201174|Actinobacteria,4DQ5F@85009|Propionibacteriales	201174|Actinobacteria	C	Galactose-1-phosphate uridyl transferase, C-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
TLS2_k127_797903_9	591158.SSMG_06755	1.028e-98	329.0	COG1349@1|root,COG1349@2|Bacteria,2H5X4@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator, DeoR family	glpR	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
TLS2_k127_797903_1	219305.MCAG_04571	6.251e-289	900.0	COG1874@1|root,COG1874@2|Bacteria,2GMDT@201174|Actinobacteria,4D90Z@85008|Micromonosporales	201174|Actinobacteria	G	beta-galactosidase	bga1	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
TLS2_k127_797903_5	1122933.JNIY01000008_gene1799	2.441e-129	426.0	COG1175@1|root,COG1175@2|Bacteria,2GMTW@201174|Actinobacteria,4F21K@85016|Cellulomonadaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_797903_7	1151126.AQYI01000002_gene110	3.021e-126	412.0	COG0395@1|root,COG0395@2|Bacteria,2GJPZ@201174|Actinobacteria,4FKBM@85023|Microbacteriaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS2_k127_797903_2	1122933.JNIY01000008_gene1797	7.605e-214	674.0	COG1653@1|root,COG1653@2|Bacteria,2GJIP@201174|Actinobacteria,4F2FN@85016|Cellulomonadaceae	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_797903_0	543632.JOJL01000009_gene6043	1.359e-297	930.0	COG3345@1|root,COG3345@2|Bacteria,2GJJ1@201174|Actinobacteria,4DCD5@85008|Micromonosporales	201174|Actinobacteria	G	Alpha-galactosidase	rafA	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
TLS2_k127_797903_10	479435.Kfla_1303	5.825e-33	130.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4DPDV@85009|Propionibacteriales	201174|Actinobacteria	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_80309_2	1048339.KB913029_gene1583	1.219e-98	325.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4ERFT@85013|Frankiales	201174|Actinobacteria	C	Dehydrogenase E1 component	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS2_k127_80309_0	219305.MCAG_02982	1.968e-169	538.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4DA2N@85008|Micromonosporales	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_80309_1	1288079.AUKN01000006_gene2937	3.339e-151	494.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria	201174|Actinobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_80309_4	1122611.KB903940_gene1737	3.577e-08	66.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS,STAS_2
TLS2_k127_80309_5	1380390.JIAT01000009_gene971	1.08e-07	61.0	COG1366@1|root,COG1366@2|Bacteria,2HRM9@201174|Actinobacteria,4CTP4@84995|Rubrobacteria	84995|Rubrobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
TLS2_k127_80309_3	266940.Krad_0224	3.362e-17	84.0	COG2203@1|root,COG2203@2|Bacteria,2IQAM@201174|Actinobacteria	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS2_k127_822722_21	405948.SACE_3591	1.422e-85	289.0	COG0406@1|root,COG0406@2|Bacteria,2GK8N@201174|Actinobacteria,4DXVM@85010|Pseudonocardiales	201174|Actinobacteria	G	PFAM Phosphoglycerate mutase	-	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
TLS2_k127_822722_22	67257.JODR01000015_gene5895	4.57e-65	228.0	298YA@1|root,2ZW25@2|Bacteria,2GIYI@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
TLS2_k127_822722_19	996637.SGM_3976	9.639e-94	317.0	COG5032@1|root,COG5032@2|Bacteria,2GME7@201174|Actinobacteria	201174|Actinobacteria	BDLTU	Phosphatidylinositol	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_822722_5	471852.Tcur_2287	1.366e-182	589.0	COG0215@1|root,COG0215@2|Bacteria,2GJZR@201174|Actinobacteria,4EH1Y@85012|Streptosporangiales	201174|Actinobacteria	J	Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins	mshC	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iNJ661.Rv2130c	tRNA-synt_1e
TLS2_k127_822722_12	1120950.KB892708_gene4411	5.9e-121	398.0	COG1938@1|root,COG1938@2|Bacteria,2GK10@201174|Actinobacteria,4DNMH@85009|Propionibacteriales	201174|Actinobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
TLS2_k127_822722_0	1123320.KB889667_gene2969	0.0	1756.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria	201174|Actinobacteria	E	Methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TLS2_k127_822722_4	1211815.CBYP010000029_gene1265	6.885e-185	594.0	COG0747@1|root,COG0747@2|Bacteria,2GMAX@201174|Actinobacteria,4EU9T@85013|Frankiales	201174|Actinobacteria	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_822722_6	526225.Gobs_0481	1.045e-143	462.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria,4ETRM@85013|Frankiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	dppB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_822722_18	44060.JODL01000001_gene2980	4.446e-99	350.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria	201174|Actinobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	appCC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_822722_7	263358.VAB18032_03210	1.465e-143	463.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4D9JJ@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	appD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_822722_9	479431.Namu_0662	3.842e-141	467.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4EUQ8@85013|Frankiales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS2_k127_822722_2	479431.Namu_0800	2.717e-275	870.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4ERZ6@85013|Frankiales	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_822722_13	479431.Namu_0799	1.433e-118	388.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4ES91@85013|Frankiales	201174|Actinobacteria	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_822722_17	73044.JNXP01000004_gene3037	1.176e-101	341.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_822722_20	1120950.KB892708_gene4420	8.02e-88	311.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria,4DRHK@85009|Propionibacteriales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_822722_14	1003195.SCAT_5164	3.839e-109	379.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria	201174|Actinobacteria	L	RecB family exonuclease	recB	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
TLS2_k127_822722_15	479432.Sros_5902	6.609e-105	352.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,4EG4K@85012|Streptosporangiales	201174|Actinobacteria	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
TLS2_k127_822722_8	749414.SBI_08475	1.233e-141	456.0	COG2519@1|root,COG2519@2|Bacteria,2GJPD@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	trmI	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
TLS2_k127_822722_1	469371.Tbis_1838	1.995e-309	955.0	COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4DZ1H@85010|Pseudonocardiales	201174|Actinobacteria	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
TLS2_k127_822722_3	68570.DC74_2116	2.144e-259	814.0	COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria	201174|Actinobacteria	S	proteasome accessory factor PafA2	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
TLS2_k127_822722_23	58344.JOEL01000018_gene5322	7.797e-20	92.0	2E9C2@1|root,333JS@2|Bacteria,2IQ5V@201174|Actinobacteria	201174|Actinobacteria	S	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation	pup	GO:0003674,GO:0005488,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0031386,GO:0032446,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044877,GO:0051603,GO:0070490,GO:0070628,GO:0070647,GO:0071704,GO:1901564,GO:1901565,GO:1901575	-	ko:K13570	-	-	-	-	ko00000,ko04121	-	-	-	Pup
TLS2_k127_822722_11	105420.BBPO01000003_gene1129	1.098e-127	414.0	COG0638@1|root,COG0638@2|Bacteria,2GJ60@201174|Actinobacteria,2NFFK@228398|Streptacidiphilus	201174|Actinobacteria	O	Proteasome subunit	prcB	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019774,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
TLS2_k127_822722_16	590998.Celf_1793	1.761e-102	342.0	COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,4F0IW@85016|Cellulomonadaceae	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
TLS2_k127_822722_10	1048339.KB913029_gene4189	2.792e-140	446.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4ERF9@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
TLS2_k127_82870_2	1229781.C272_13593	5.813e-144	460.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,4F9I1@85019|Brevibacteriaceae	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	fdhA	-	1.2.1.46	ko:K00148	ko00625,ko00680,ko01100,ko01120,ko01200,map00625,map00680,map01100,map01120,map01200	-	R00604	RC00188	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N,AlaDh_PNT_C
TLS2_k127_82870_0	1120950.KB892746_gene3508	1.23e-206	653.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4DPAI@85009|Propionibacteriales	201174|Actinobacteria	L	DNA primase, small subunit	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
TLS2_k127_82870_3	1120954.ATXE01000002_gene947	6.844e-56	216.0	COG0500@1|root,COG2226@2|Bacteria,2IDZY@201174|Actinobacteria,4DUY7@85009|Propionibacteriales	201174|Actinobacteria	Q	Methionine biosynthesis protein MetW	metW	-	-	-	-	-	-	-	-	-	-	-	MetW,Methyltransf_11
TLS2_k127_82870_1	1121933.AUHH01000028_gene1890	5.378e-157	502.0	COG2021@1|root,COG2021@2|Bacteria,2GKNJ@201174|Actinobacteria,4DNSW@85009|Propionibacteriales	201174|Actinobacteria	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metX	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_872087_0	234621.RER_32160	1.15e-90	305.0	COG3268@1|root,COG3268@2|Bacteria,2GNGH@201174|Actinobacteria,4FXUS@85025|Nocardiaceae	201174|Actinobacteria	S	Saccharopine dehydrogenase NADP binding domain	LYS1	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
TLS2_k127_872087_1	1380347.JNII01000007_gene137	9.141e-89	303.0	COG0697@1|root,COG0697@2|Bacteria,2GKVT@201174|Actinobacteria,4EWMM@85013|Frankiales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_875115_8	1122138.AQUZ01000019_gene8179	5.365e-08	56.0	COG2890@1|root,COG2890@2|Bacteria,2I3R2@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_875115_4	471852.Tcur_0550	1.37e-84	301.0	COG2227@1|root,COG2227@2|Bacteria,2I3C3@201174|Actinobacteria,4ER5A@85012|Streptosporangiales	201174|Actinobacteria	H	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_875115_6	1415780.JPOG01000001_gene1457	2.264e-67	250.0	COG2267@1|root,COG2267@2|Bacteria,1MUG8@1224|Proteobacteria,1RMFE@1236|Gammaproteobacteria,1X43J@135614|Xanthomonadales	135614|Xanthomonadales	I	Alpha beta hydrolase	cpo	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_875115_7	1449044.JMLE01000002_gene4321	8.123e-27	128.0	2E3U2@1|root,32YRF@2|Bacteria,2GSNJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_875115_1	1123024.AUII01000015_gene3718	9.988e-170	548.0	COG2909@1|root,COG2909@2|Bacteria,2I3S2@201174|Actinobacteria,4ECY0@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_875115_2	1298863.AUEP01000003_gene3047	3.14e-150	486.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4DQ0U@85009|Propionibacteriales	201174|Actinobacteria	P	Flavin-binding monooxygenase-like	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS2_k127_875115_3	208439.AJAP_30525	2.842e-120	410.0	COG2378@1|root,COG2378@2|Bacteria,2GIZC@201174|Actinobacteria,4E1PX@85010|Pseudonocardiales	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
TLS2_k127_875115_0	1206739.BAGJ01000011_gene3401	2.321e-175	557.0	COG0596@1|root,COG0596@2|Bacteria,2GK79@201174|Actinobacteria,4FUCF@85025|Nocardiaceae	201174|Actinobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	ko:K21159	ko01059,map01059	-	-	-	ko00000,ko00001	-	-	-	EHN
TLS2_k127_875115_5	296591.Bpro_1660	4.165e-75	270.0	COG0671@1|root,COG0671@2|Bacteria,1MWK1@1224|Proteobacteria,2WBYH@28216|Betaproteobacteria,4AIJ8@80864|Comamonadaceae	28216|Betaproteobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS2_k127_943520_0	234267.Acid_3077	1.389e-263	838.0	COG0304@1|root,COG3321@1|root,COG4221@1|root,COG0304@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,3Y347@57723|Acidobacteria	57723|Acidobacteria	Q	Acyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
TLS2_k127_943520_1	502025.Hoch_2100	8.315e-58	207.0	COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,1P6RE@1224|Proteobacteria,43A2M@68525|delta/epsilon subdivisions,2X1XW@28221|Deltaproteobacteria,2YX2T@29|Myxococcales	28221|Deltaproteobacteria	I	Acetyl-CoA carboxylase, central region	-	-	-	-	-	-	-	-	-	-	-	-	ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
TLS2_k127_947165_8	471853.Bcav_0148	7.967e-21	106.0	COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria	201174|Actinobacteria	V	HNH endonuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS2_k127_947165_7	1206101.AZXC01000024_gene834	3.905e-23	106.0	COG1722@1|root,COG1722@2|Bacteria,2GR0U@201174|Actinobacteria	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
TLS2_k127_947165_4	1120950.KB892823_gene550	2.779e-155	509.0	COG1570@1|root,COG1570@2|Bacteria,2GJAS@201174|Actinobacteria,4DNJ0@85009|Propionibacteriales	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TLS2_k127_947165_3	1120950.KB892823_gene547	2.633e-161	516.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4DP0N@85009|Propionibacteriales	201174|Actinobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
TLS2_k127_947165_9	452652.KSE_47930	0.0004255	52.0	2F5NF@1|root,33Y7D@2|Bacteria,2IKYZ@201174|Actinobacteria,2M371@2063|Kitasatospora	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_947165_5	351607.Acel_1860	1.366e-129	431.0	COG1322@1|root,COG1322@2|Bacteria,2GP4U@201174|Actinobacteria,4ERYH@85013|Frankiales	201174|Actinobacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
TLS2_k127_947165_2	390989.JOEG01000003_gene4566	6.525e-177	567.0	COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria,4DASI@85008|Micromonosporales	201174|Actinobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
TLS2_k127_947165_0	1386089.N865_01825	9.53e-194	628.0	COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria,4FH88@85021|Intrasporangiaceae	201174|Actinobacteria	C	FMN-dependent dehydrogenase	-	-	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100	-	R00196	RC00044	ko00000,ko00001,ko01000	-	-	-	FMN_dh
TLS2_k127_947165_1	1386089.N865_01830	2.545e-188	612.0	COG2421@1|root,COG2421@2|Bacteria,2HQSF@201174|Actinobacteria,4FI5T@85021|Intrasporangiaceae	201174|Actinobacteria	C	Acetamidase/Formamidase family	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
TLS2_k127_947165_6	710696.Intca_1447	1.148e-38	147.0	COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_952556_1	103733.JNYO01000004_gene8045	1.533e-235	741.0	COG2303@1|root,COG2303@2|Bacteria,2GJ3J@201174|Actinobacteria,4DYHW@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol degradation process. Required for virulence	choD	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016614,GO:0016899,GO:0016995,GO:0044419,GO:0051704,GO:0055114	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,GMC_oxred_C,GMC_oxred_N
TLS2_k127_952556_3	58344.JOEL01000052_gene6115	3.419e-172	572.0	COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	gabD2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009013,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_952556_2	110319.CF8_0773	3.776e-192	604.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4DN1G@85009|Propionibacteriales	201174|Actinobacteria	F	IMP dehydrogenase / GMP reductase domain	guaB3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
TLS2_k127_952556_0	479435.Kfla_6026	5.536e-243	758.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GITZ@201174|Actinobacteria,4DN68@85009|Propionibacteriales	201174|Actinobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TLS2_k127_952556_5	1394178.AWOO02000003_gene2675	3.244e-60	230.0	COG1595@1|root,COG1595@2|Bacteria,2GM8T@201174|Actinobacteria,4EJD0@85012|Streptosporangiales	201174|Actinobacteria	K	ECF sigma factor	sigD	GO:0000988,GO:0000990,GO:0002791,GO:0003674,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032879,GO:0032880,GO:0043254,GO:0044087,GO:0044419,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051223,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0070201,GO:0080090,GO:0090087,GO:0140110,GO:1903506,GO:1903530,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_952556_4	1394178.AWOO02000076_gene1941	2.249e-72	256.0	COG0789@1|root,COG0789@2|Bacteria,2I8T8@201174|Actinobacteria,4EFXZ@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
TLS2_k127_952556_6	266940.Krad_0737	4.121e-45	166.0	2CC1Y@1|root,32S23@2|Bacteria,2IQS5@201174|Actinobacteria	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB3	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS2_k127_964158_5	469383.Cwoe_2462	5.706e-11	64.0	COG1595@1|root,COG1595@2|Bacteria,2GMRK@201174|Actinobacteria,4CS48@84995|Rubrobacteria	84995|Rubrobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
TLS2_k127_964158_4	383372.Rcas_2198	4.385e-90	302.0	COG0412@1|root,COG0412@2|Bacteria,2G868@200795|Chloroflexi,37610@32061|Chloroflexia	32061|Chloroflexia	Q	PFAM dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TLS2_k127_964158_2	644283.Micau_2760	1.361e-154	500.0	COG3416@1|root,COG3416@2|Bacteria,2HVVA@201174|Actinobacteria,4DEHY@85008|Micromonosporales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS2_k127_964158_0	103733.JNYO01000012_gene2803	1.921e-231	726.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,2GIXE@201174|Actinobacteria,4E0ZQ@85010|Pseudonocardiales	201174|Actinobacteria	EK	Cystathionine beta-synthase	cbs	GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
TLS2_k127_964158_3	1123320.KB889574_gene5696	5.776e-108	377.0	COG2755@1|root,COG2755@2|Bacteria,2GMVS@201174|Actinobacteria	201174|Actinobacteria	E	G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS2_k127_964158_1	1120950.KB892752_gene6192	7.044e-201	631.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4DPEV@85009|Propionibacteriales	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_964158_6	543632.JOJL01000008_gene5908	3.126e-06	53.0	2978F@1|root,2ZUG8@2|Bacteria,2GXAY@201174|Actinobacteria,4DGCW@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
## 3222 queries scanned
## Total time (seconds): 30.7174654006958
## Rate: 104.89 q/s