## Fri Nov 15 04:25:25 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin28/TLS_2_bin.7.fa -m mmseqs --itype genome -o TLS_2_bin.7 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/TLS_2_bin.7 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TLS2_k127_1005109_4	66373.JOFQ01000001_gene1884	1.218e-09	61.0	2E62U@1|root,330RX@2|Bacteria,2GTSM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1005109_1	929712.KI912613_gene2673	1.006e-100	344.0	COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria,4CPAI@84995|Rubrobacteria	84995|Rubrobacteria	EF	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
TLS2_k127_1005109_0	1121946.AUAX01000005_gene5339	7.44e-124	411.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4D8CT@85008|Micromonosporales	201174|Actinobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
TLS2_k127_1005109_3	370438.PTH_0096	1.338e-31	140.0	COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,261HE@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_1005109_2	1380390.JIAT01000009_gene744	9.5e-45	169.0	COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria,4CPN8@84995|Rubrobacteria	84995|Rubrobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TLS2_k127_1021967_1	469383.Cwoe_0824	2.597e-149	514.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4CPN1@84995|Rubrobacteria	84995|Rubrobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
TLS2_k127_1021967_0	469383.Cwoe_0822	1.105e-207	666.0	COG0046@1|root,COG0046@2|Bacteria,2GKG6@201174|Actinobacteria,4CP9W@84995|Rubrobacteria	84995|Rubrobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_1021967_2	1380390.JIAT01000009_gene406	2.09e-46	179.0	COG0697@1|root,COG0697@2|Bacteria,2GK49@201174|Actinobacteria,4CQ0Q@84995|Rubrobacteria	84995|Rubrobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_1021967_3	426716.JOAJ01000001_gene769	1.527e-12	80.0	COG1670@1|root,COG1670@2|Bacteria,2IKXU@201174|Actinobacteria,4G93M@85025|Nocardiaceae	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_1027808_2	469383.Cwoe_3753	1.012e-85	296.0	COG1003@1|root,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria,4CPH8@84995|Rubrobacteria	84995|Rubrobacteria	E	Aminotransferase class-V	-	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
TLS2_k127_1027808_0	469383.Cwoe_3754	8.265e-134	455.0	COG0403@1|root,COG0403@2|Bacteria,2IBH2@201174|Actinobacteria,4CP8Z@84995|Rubrobacteria	84995|Rubrobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
TLS2_k127_1027808_3	1283299.AUKG01000002_gene4629	9.649e-50	196.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4CQGM@84995|Rubrobacteria	84995|Rubrobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
TLS2_k127_1027808_1	1380390.JIAT01000010_gene4156	2.567e-111	370.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4CP79@84995|Rubrobacteria	84995|Rubrobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TLS2_k127_1027808_4	292459.STH2842	4.834e-48	177.0	COG3033@1|root,COG3033@2|Bacteria,1TRGV@1239|Firmicutes,248WC@186801|Clostridia	186801|Clostridia	E	Beta-eliminating lyase	tpl	-	4.1.99.2	ko:K01668	ko00350,map00350	-	R00728	RC00355,RC00364	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_1037227_4	469383.Cwoe_1510	4.551e-13	72.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	1.8.2.1	ko:K05301	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00528	RC00168	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3
TLS2_k127_1037227_3	929712.KI912613_gene2298	3.638e-25	113.0	28TIQ@1|root,2ZFSJ@2|Bacteria,2I6IR@201174|Actinobacteria,4CSHG@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1037227_1	1380390.JIAT01000014_gene6067	2.967e-75	263.0	COG1845@1|root,COG1845@2|Bacteria,2GKK8@201174|Actinobacteria,4CSHZ@84995|Rubrobacteria	84995|Rubrobacteria	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
TLS2_k127_1037227_2	469383.Cwoe_1901	2.99e-69	255.0	COG1113@1|root,COG1113@2|Bacteria	2|Bacteria	E	amino acid transport	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_1037227_0	1283299.AUKG01000001_gene3221	1.347e-111	365.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4CS3H@84995|Rubrobacteria	84995|Rubrobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
TLS2_k127_1052088_2	1304275.C41B8_04326	1.777e-36	140.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
TLS2_k127_1052088_1	867903.ThesuDRAFT_02331	8.807e-95	326.0	COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,2499P@186801|Clostridia,3WCZC@538999|Clostridiales incertae sedis	186801|Clostridia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_1052088_0	262724.TT_C1533	4.159e-178	579.0	COG0449@1|root,COG0449@2|Bacteria,1WIM6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
TLS2_k127_1052088_3	1146883.BLASA_0947	2.749e-34	143.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_4,Reg_prop,Y_Y_Y
TLS2_k127_1060753_6	444157.Tneu_0042	1.958e-12	69.0	COG0295@1|root,arCOG04173@2157|Archaea,2XQU4@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM CMP dCMP deaminase zinc-binding	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
TLS2_k127_1060753_2	469383.Cwoe_2851	6.502e-82	285.0	COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria,4CPY3@84995|Rubrobacteria	84995|Rubrobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
TLS2_k127_1060753_3	525904.Tter_0604	3.234e-74	268.0	COG1164@1|root,COG1164@2|Bacteria,2NQ8K@2323|unclassified Bacteria	2|Bacteria	E	Oligoendopeptidase f	-	-	3.4.15.1	ko:K01283,ko:K08602	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	-
TLS2_k127_1060753_1	1120950.KB892785_gene249	5.464e-121	404.0	COG0274@1|root,COG0274@2|Bacteria,2GJIR@201174|Actinobacteria,4DNUJ@85009|Propionibacteriales	201174|Actinobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS2_k127_1060753_4	471853.Bcav_3749	1.213e-57	207.0	COG3832@1|root,COG3832@2|Bacteria,2IQUJ@201174|Actinobacteria	201174|Actinobacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_1060753_0	1254432.SCE1572_30430	1.141e-206	651.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2X250@28221|Deltaproteobacteria,2YXZE@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_1065265_2	1283299.AUKG01000002_gene4960	5.617e-44	177.0	COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria,4CPZY@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1
TLS2_k127_1065265_1	1380390.JIAT01000010_gene4569	3.299e-48	177.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4CQ8I@84995|Rubrobacteria	84995|Rubrobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
TLS2_k127_1065265_4	1283299.AUKG01000002_gene4958	3.095e-17	84.0	2AUU1@1|root,31KH5@2|Bacteria,2HPC3@201174|Actinobacteria,4CQQ6@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1065265_0	1160718.SU9_24627	1.396e-214	699.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria	201174|Actinobacteria	JM	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
TLS2_k127_1065265_3	446470.Snas_3744	6.697e-19	91.0	COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4EYIN@85014|Glycomycetales	201174|Actinobacteria	I	CDP-alcohol phosphatidyltransferase	pgsA2	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_1065442_4	110319.CF8_1369	1.094e-55	222.0	COG1629@1|root,COG4771@2|Bacteria,2IN13@201174|Actinobacteria,4DREY@85009|Propionibacteriales	201174|Actinobacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1065442_1	1283299.AUKG01000002_gene4478	5.787e-103	364.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4CSW8@84995|Rubrobacteria	84995|Rubrobacteria	E	Belongs to the peptidase M24B family	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS2_k127_1065442_9	1128421.JAGA01000003_gene2971	0.0004976	53.0	2EG64@1|root,339XZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1065442_2	309801.trd_1505	3.992e-95	347.0	COG0612@1|root,COG0612@2|Bacteria,2G672@200795|Chloroflexi,27XSH@189775|Thermomicrobia	189775|Thermomicrobia	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_1065442_7	867845.KI911784_gene363	5.133e-28	121.0	COG0824@1|root,COG0824@2|Bacteria,2G7HH@200795|Chloroflexi,377ME@32061|Chloroflexia	32061|Chloroflexia	S	PFAM thioesterase superfamily protein	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT_2
TLS2_k127_1065442_8	1380390.JIAT01000011_gene2685	2.45e-24	117.0	COG0449@1|root,COG0449@2|Bacteria,2IIQ7@201174|Actinobacteria,4CQF9@84995|Rubrobacteria	84995|Rubrobacteria	M	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	-
TLS2_k127_1065442_5	926560.KE387023_gene2926	5.803e-46	183.0	COG4101@1|root,COG4101@2|Bacteria,1WMQC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_1065442_0	469383.Cwoe_2142	8.441e-116	406.0	COG0520@1|root,COG0520@2|Bacteria,2GKAF@201174|Actinobacteria,4CSVS@84995|Rubrobacteria	84995|Rubrobacteria	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_1065442_3	485913.Krac_11103	2.729e-91	317.0	COG0451@1|root,COG0451@2|Bacteria,2G9SG@200795|Chloroflexi	200795|Chloroflexi	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_1065442_6	379066.GAU_3910	1.188e-30	129.0	COG3663@1|root,COG3663@2|Bacteria,1ZTNU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_1095379_3	1401067.HMPREF0872_05755	1.742e-63	232.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,4H37S@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	-	-	-	-	-	-	-	-	-	Dus
TLS2_k127_1095379_4	1120948.KB903227_gene4836	5.863e-59	214.0	COG0668@1|root,COG0668@2|Bacteria,2HD92@201174|Actinobacteria,4E0HQ@85010|Pseudonocardiales	201174|Actinobacteria	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
TLS2_k127_1095379_0	439235.Dalk_1526	5.51e-96	353.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria,2MKIU@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,Pkinase,TPR_12
TLS2_k127_1095379_5	326427.Cagg_2385	3.653e-51	209.0	COG4166@1|root,COG4166@2|Bacteria,2G8A0@200795|Chloroflexi,375R9@32061|Chloroflexia	32061|Chloroflexia	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
TLS2_k127_1095379_2	1380390.JIAT01000011_gene2850	9.669e-86	291.0	COG1521@1|root,COG1521@2|Bacteria,2GMRQ@201174|Actinobacteria,4CQ5C@84995|Rubrobacteria	84995|Rubrobacteria	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
TLS2_k127_1095379_7	754252.PFREUD_14260	2.294e-19	96.0	2AFXT@1|root,3161G@2|Bacteria,2IKPZ@201174|Actinobacteria,4DR0E@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF2469)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2469
TLS2_k127_1095379_6	477974.Daud_0097	7.786e-38	156.0	COG0801@1|root,COG0801@2|Bacteria,1V6PR@1239|Firmicutes,249YP@186801|Clostridia,2629P@186807|Peptococcaceae	186801|Clostridia	H	PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
TLS2_k127_1095379_8	1246474.ANBE01000031_gene3339	9.335e-13	80.0	COG1539@1|root,COG1539@2|Bacteria,2IHSW@201174|Actinobacteria,4EJZC@85012|Streptosporangiales	201174|Actinobacteria	H	Dihydroneopterin aldolase	folB	GO:0008150,GO:0040007	1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8	ko:K01633,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00840	R03503,R03504,R11037,R11073	RC00002,RC00017,RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
TLS2_k127_1095379_1	469383.Cwoe_1674	5.602e-88	298.0	COG0294@1|root,COG0294@2|Bacteria,2GJDQ@201174|Actinobacteria,4CPWZ@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TLS2_k127_1098474_8	471853.Bcav_0957	1.694e-09	67.0	COG3401@1|root,COG4733@1|root,COG3401@2|Bacteria,COG4733@2|Bacteria,2HCWC@201174|Actinobacteria	201174|Actinobacteria	Q	PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	Malectin,PA14
TLS2_k127_1098474_2	1267535.KB906767_gene505	4.215e-81	284.0	COG1793@1|root,COG1793@2|Bacteria,3Y45N@57723|Acidobacteria,2JIH0@204432|Acidobacteriia	204432|Acidobacteriia	L	ATP dependent DNA ligase C terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
TLS2_k127_1098474_1	644966.Tmar_0951	3.141e-136	450.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,3WCS5@538999|Clostridiales incertae sedis	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS2_k127_1098474_6	935866.JAER01000021_gene817	8.316e-16	87.0	COG2885@1|root,COG3291@1|root,COG2885@2|Bacteria,COG3291@2|Bacteria,2I7AY@201174|Actinobacteria	2|Bacteria	M	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	3.1.4.46,3.2.1.8	ko:K01126,ko:K01181	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	DUF748,Laminin_G_3,NLPC_P60,PKD,fn3
TLS2_k127_1098474_3	33876.JNXY01000016_gene7115	2.265e-63	233.0	COG0637@1|root,COG0637@2|Bacteria,2I362@201174|Actinobacteria,4DC3H@85008|Micromonosporales	201174|Actinobacteria	S	HAD-superfamily hydrolase, subfamily IA	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS2_k127_1098474_7	309807.SRU_2769	4.172e-14	82.0	COG2128@1|root,COG2128@2|Bacteria,4NN22@976|Bacteroidetes,1FK4T@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	PA26 p53-induced protein (sestrin)	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_1098474_5	926550.CLDAP_02880	1.188e-18	88.0	COG2128@1|root,COG2128@2|Bacteria,2G7D8@200795|Chloroflexi	200795|Chloroflexi	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS2_k127_1098474_0	469383.Cwoe_3473	6.92e-142	464.0	COG0569@1|root,COG0569@2|Bacteria,2GKB9@201174|Actinobacteria,4CQH1@84995|Rubrobacteria	84995|Rubrobacteria	P	TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS2_k127_1098474_4	1158338.JNLJ01000005_gene1465	6.282e-33	138.0	COG0490@1|root,COG0490@2|Bacteria,2G45Z@200783|Aquificae	200783|Aquificae	P	TrkA-C domain protein	-	-	-	ko:K07228	-	-	-	-	ko00000	-	-	-	TrkA_C
TLS2_k127_1098474_9	1324957.K933_03355	1.09e-06	53.0	COG0475@1|root,arCOG01955@2157|Archaea,2XT4U@28890|Euryarchaeota,23SD1@183963|Halobacteria	183963|Halobacteria	P	COG0475 Kef-type K transport systems, membrane components	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
TLS2_k127_1105648_2	42256.RradSPS_1300	1.828e-116	393.0	COG0402@1|root,COG0402@2|Bacteria,2GM63@201174|Actinobacteria,4CPPR@84995|Rubrobacteria	84995|Rubrobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_1105648_1	1382306.JNIM01000001_gene856	8.424e-171	553.0	COG1001@1|root,COG1001@2|Bacteria,2G64P@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
TLS2_k127_1105648_4	526225.Gobs_3389	2.224e-76	265.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4EVPF@85013|Frankiales	201174|Actinobacteria	C	PFAM molybdopterin dehydrogenase, FAD-binding	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_1105648_5	436229.JOEH01000022_gene689	7.472e-39	160.0	COG2080@1|root,COG2080@2|Bacteria,2GMXT@201174|Actinobacteria,2NENH@228398|Streptacidiphilus	201174|Actinobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_1105648_0	266117.Rxyl_2839	1.553e-268	857.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4CPP1@84995|Rubrobacteria	84995|Rubrobacteria	C	xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_1105648_6	1295642.H839_09033	2.263e-14	81.0	COG3238@1|root,COG3238@2|Bacteria,1V73B@1239|Firmicutes,4HIJC@91061|Bacilli,1WGAF@129337|Geobacillus	91061|Bacilli	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
TLS2_k127_1105648_3	1379698.RBG1_1C00001G0907	3.886e-83	290.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	bamA	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788	3.7.1.21	ko:K07539,ko:K18570	ko00332,ko00362,ko01100,ko01120,ko01130,ko01220,map00332,map00362,map01100,map01120,map01130,map01220	M00541	R05593,R05594,R10696,R10750	RC01430,RC01431,RC03237,RC03270	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_1129618_4	1120950.KB892776_gene796	3.03e-72	249.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4DP99@85009|Propionibacteriales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinP	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
TLS2_k127_1129618_1	479432.Sros_7870	3.476e-141	458.0	COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria,4EHZF@85012|Streptosporangiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_1129618_0	479435.Kfla_0728	8.638e-219	707.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria,4DU3U@85009|Propionibacteriales	201174|Actinobacteria	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
TLS2_k127_1129618_5	1150864.MILUP08_40578	2.88e-66	233.0	COG0262@1|root,COG0262@2|Bacteria,2GMZV@201174|Actinobacteria,4DCI1@85008|Micromonosporales	201174|Actinobacteria	H	bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_1129618_2	1191523.MROS_0765	1.912e-138	452.0	COG2195@1|root,COG2195@2|Bacteria	2|Bacteria	E	Cleaves the N-terminal amino acid of tripeptides	pepT	GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0034701,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045148,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M42
TLS2_k127_1129618_7	1463909.KL585946_gene1702	1.611e-16	83.0	2BUTG@1|root,32Q51@2|Bacteria,2ISEW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1129618_8	1283287.KB822586_gene876	1.646e-13	85.0	2EK8X@1|root,33DZ6@2|Bacteria,2GWJW@201174|Actinobacteria,4DSK4@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1129618_6	1157640.AQWO01000010_gene3005	1.76e-26	110.0	COG0308@1|root,COG0308@2|Bacteria,2GJWF@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
TLS2_k127_1141536_1	1380390.JIAT01000010_gene4014	1.499e-103	342.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CPWA@84995|Rubrobacteria	84995|Rubrobacteria	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1141536_3	469383.Cwoe_1615	1.495e-74	269.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria,4CSU4@84995|Rubrobacteria	84995|Rubrobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS2_k127_1141536_2	1463887.KL589979_gene3804	4.402e-79	275.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_1141536_0	867845.KI911784_gene1758	8.435e-132	450.0	COG1012@1|root,COG1012@2|Bacteria,2G5JE@200795|Chloroflexi,375BH@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_1141536_4	287.DR97_368	1.346e-32	145.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,1RNJ9@1236|Gammaproteobacteria,1YFM2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS2_k127_1146043_11	227882.SAV_3392	9.148e-22	108.0	COG0515@1|root,COG0515@2|Bacteria,2IKPQ@201174|Actinobacteria	201174|Actinobacteria	KLT	Domain of unknown function (DUF4328)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4328
TLS2_k127_1146043_8	1121428.DESHY_10182___1	1.918e-49	188.0	COG2064@1|root,COG2064@2|Bacteria,1V2T1@1239|Firmicutes,24GQ4@186801|Clostridia,261D6@186807|Peptococcaceae	186801|Clostridia	NU	PFAM type II secretion system	tadC	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_1146043_7	110319.CF8_2740	5.225e-53	212.0	COG2304@1|root,COG4965@1|root,COG2304@2|Bacteria,COG4965@2|Bacteria,2H577@201174|Actinobacteria,4DQ0A@85009|Propionibacteriales	201174|Actinobacteria	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF,VWA_2
TLS2_k127_1146043_0	1380370.JIBA01000003_gene2732	2.819e-161	521.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4FE8N@85021|Intrasporangiaceae	201174|Actinobacteria	U	pilus assembly protein ATPase CpaF	flpF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS2_k127_1146043_6	367299.JOEE01000003_gene2949	7.263e-61	227.0	COG4963@1|root,COG4963@2|Bacteria,2GNHI@201174|Actinobacteria,4FG1C@85021|Intrasporangiaceae	201174|Actinobacteria	D	chromosome partitioning	flpE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CbiA,ParA
TLS2_k127_1146043_15	110319.CF8_2737	2.738e-06	58.0	COG3745@1|root,COG3745@2|Bacteria,2INHS@201174|Actinobacteria	201174|Actinobacteria	U	Pilus assembly protein	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
TLS2_k127_1146043_12	1304876.AZVC01000001_gene1345	1.445e-11	77.0	COG4655@1|root,COG4655@2|Bacteria,2IGK1@201174|Actinobacteria	201174|Actinobacteria	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
TLS2_k127_1146043_13	1347369.CCAD010000072_gene3594	6.712e-08	62.0	COG4961@1|root,COG4961@2|Bacteria,1VFNR@1239|Firmicutes,4HNWE@91061|Bacilli,1ZJ5U@1386|Bacillus	91061|Bacilli	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS2_k127_1146043_9	929712.KI912613_gene4594	2.064e-25	121.0	COG0739@1|root,COG0741@1|root,COG0739@2|Bacteria,COG0741@2|Bacteria,2I2XS@201174|Actinobacteria,4CPBG@84995|Rubrobacteria	84995|Rubrobacteria	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT_2
TLS2_k127_1146043_10	392500.Swoo_0745	8.41e-25	107.0	COG1430@1|root,COG1430@2|Bacteria,1N7U4@1224|Proteobacteria,1T8QK@1236|Gammaproteobacteria,2QCDE@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
TLS2_k127_1146043_5	526226.Gbro_3383	7.736e-62	224.0	COG1597@1|root,COG1597@2|Bacteria,2GNNM@201174|Actinobacteria,4GAX8@85026|Gordoniaceae	201174|Actinobacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS2_k127_1146043_14	1341646.CBMO010000084_gene90	2.271e-06	54.0	COG0346@1|root,COG0346@2|Bacteria,2IKNQ@201174|Actinobacteria,239UW@1762|Mycobacteriaceae	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_1146043_2	479434.Sthe_3156	1.286e-116	392.0	COG0803@1|root,COG0803@2|Bacteria,2G8F6@200795|Chloroflexi,27XHP@189775|Thermomicrobia	200795|Chloroflexi	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K09818,ko:K11707	ko02010,map02010	M00243,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ZnuA
TLS2_k127_1146043_3	479434.Sthe_3155	1.268e-115	377.0	COG1121@1|root,COG1121@2|Bacteria,2G7X2@200795|Chloroflexi,27XH6@189775|Thermomicrobia	200795|Chloroflexi	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K09820,ko:K11710	ko02010,map02010	M00243,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
TLS2_k127_1146043_1	880073.Calab_1771	5.333e-118	389.0	COG1108@1|root,COG1108@2|Bacteria,2NPC2@2323|unclassified Bacteria	2|Bacteria	U	ABC 3 transport family	mntC	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944	-	ko:K11708	ko02010,map02010	M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC-3,Fe_dep_repr_C
TLS2_k127_1146043_4	479434.Sthe_3153	8.455e-94	339.0	COG1108@1|root,COG1108@2|Bacteria,2G7XS@200795|Chloroflexi	200795|Chloroflexi	P	PFAM ABC-3 protein	-	-	-	ko:K11709	ko02010,map02010	M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC-3
TLS2_k127_1156950_0	326424.FRAAL4193	1.953e-67	250.0	COG0745@1|root,COG3629@1|root,COG0745@2|Bacteria,COG3629@2|Bacteria	2|Bacteria	K	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Response_reg,Trans_reg_C
TLS2_k127_1156950_2	1449357.JQLK01000001_gene775	9.347e-05	49.0	2ENXP@1|root,33GIJ@2|Bacteria,1WK6N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1156950_1	1128421.JAGA01000001_gene2422	5.458e-60	216.0	COG1522@1|root,COG2146@1|root,COG3253@1|root,COG1522@2|Bacteria,COG2146@2|Bacteria,COG3253@2|Bacteria,2NQGU@2323|unclassified Bacteria	2|Bacteria	K	AsnC-type helix-turn-helix domain	MA20_05845	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Chlor_dismutase,HTH_AsnC-type,Rieske
TLS2_k127_1201701_2	469383.Cwoe_5890	8.534e-55	201.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4CR71@84995|Rubrobacteria	84995|Rubrobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_1201701_1	1031288.AXAA01000014_gene358	1.965e-55	220.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia,36EHU@31979|Clostridiaceae	186801|Clostridia	E	Family 5	oppA	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
TLS2_k127_1201701_0	1283299.AUKG01000002_gene3889	3.87e-67	237.0	COG0224@1|root,COG0224@2|Bacteria,2GJ7Q@201174|Actinobacteria,4CPD1@84995|Rubrobacteria	84995|Rubrobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
TLS2_k127_1220767_4	35754.JNYJ01000001_gene7332	3.583e-06	49.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4D8IE@85008|Micromonosporales	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
TLS2_k127_1220767_0	471852.Tcur_1235	2.814e-209	673.0	COG0737@1|root,COG0737@2|Bacteria,2GKC3@201174|Actinobacteria,4EHCF@85012|Streptosporangiales	201174|Actinobacteria	F	5'-nucleotidase, C-terminal domain	cpdB	-	3.1.3.5,3.1.3.6,3.1.4.16	ko:K01081,ko:K01119	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
TLS2_k127_1220767_1	469383.Cwoe_2872	9.514e-173	571.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4CPF8@84995|Rubrobacteria	84995|Rubrobacteria	J	Ribosomal protein S1-like RNA-binding domain	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
TLS2_k127_1220767_3	457415.HMPREF1006_00778	3.901e-19	95.0	COG0237@1|root,COG0237@2|Bacteria,3TAYZ@508458|Synergistetes	508458|Synergistetes	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE,CutA1
TLS2_k127_1220767_2	428125.CLOLEP_03922	8.269e-30	134.0	COG0741@1|root,COG0741@2|Bacteria,1V6K4@1239|Firmicutes,24JB5@186801|Clostridia,3WJDD@541000|Ruminococcaceae	186801|Clostridia	M	Soluble lytic murein transglycosylase and related regulatory proteins	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
TLS2_k127_1240473_4	1463920.JOGB01000075_gene1224	7.035e-16	78.0	COG2261@1|root,COG2261@2|Bacteria,2GQR5@201174|Actinobacteria	201174|Actinobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS2_k127_1240473_0	1380386.JIAW01000003_gene674	3.413e-151	504.0	COG1282@1|root,COG1282@2|Bacteria,2GNKB@201174|Actinobacteria,236BI@1762|Mycobacteriaceae	201174|Actinobacteria	C	the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
TLS2_k127_1240473_2	40571.JOEA01000001_gene5123	4.891e-27	126.0	COG3288@1|root,COG3288@2|Bacteria,2IKR9@201174|Actinobacteria,4E5KZ@85010|Pseudonocardiales	201174|Actinobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	pntAB	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
TLS2_k127_1240473_1	479434.Sthe_1945	4.232e-125	417.0	COG3288@1|root,COG3288@2|Bacteria,2GB86@200795|Chloroflexi,27XYV@189775|Thermomicrobia	189775|Thermomicrobia	C	Alanine dehydrogenase/PNT, N-terminal domain	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TLS2_k127_1240473_5	376733.IT41_00055	8.423e-10	72.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2PV2I@265|Paracoccus	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS2_k127_1240473_3	221288.JH992901_gene3767	8.602e-25	121.0	COG0823@1|root,COG0823@2|Bacteria,1G8I3@1117|Cyanobacteria	1117|Cyanobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
TLS2_k127_1242380_0	1122182.KB903837_gene3780	3.537e-104	346.0	COG0697@1|root,COG0697@2|Bacteria,2I91Y@201174|Actinobacteria,4DF2R@85008|Micromonosporales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_1242380_2	269800.Tfu_1443	9.344e-49	178.0	COG1145@1|root,32SB1@2|Bacteria,2IJFQ@201174|Actinobacteria,4EP28@85012|Streptosporangiales	201174|Actinobacteria	C	Domain of Unknown Function (DUF326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF326
TLS2_k127_1242380_3	463191.SSEG_02357	1.079e-48	187.0	COG0346@1|root,COG0346@2|Bacteria,2IIMV@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,TetR_N
TLS2_k127_1242380_1	1449347.JQLN01000004_gene6846	6.731e-61	224.0	COG4430@1|root,COG4430@2|Bacteria,2II0D@201174|Actinobacteria,2M5RX@2063|Kitasatospora	201174|Actinobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
TLS2_k127_1242380_4	518766.Rmar_0572	1.213e-41	174.0	COG0438@1|root,COG0438@2|Bacteria,4NE6S@976|Bacteroidetes,1FIXH@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
TLS2_k127_1242380_5	1122182.KB903814_gene3219	4.011e-41	166.0	COG3919@1|root,COG3919@2|Bacteria,2HUNF@201174|Actinobacteria,4DKV4@85008|Micromonosporales	201174|Actinobacteria	S	ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1242380_6	1123258.AQXZ01000017_gene3922	6.889e-38	154.0	COG2114@1|root,COG2197@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,2I5GH@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc
TLS2_k127_125518_8	1122239.AULS01000001_gene1850	2.506e-85	285.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4FM80@85023|Microbacteriaceae	201174|Actinobacteria	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_125518_7	1298863.AUEP01000008_gene1264	7.273e-90	314.0	COG3191@1|root,COG3191@2|Bacteria,2H89D@201174|Actinobacteria,4DRX9@85009|Propionibacteriales	201174|Actinobacteria	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
TLS2_k127_125518_4	1298863.AUEP01000008_gene1265	5.687e-109	364.0	COG0123@1|root,COG0123@2|Bacteria,2I8UK@201174|Actinobacteria,4DU14@85009|Propionibacteriales	201174|Actinobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TLS2_k127_125518_9	401053.AciPR4_2252	2.828e-63	240.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3XQ@57723|Acidobacteria	57723|Acidobacteria	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
TLS2_k127_125518_3	28444.JODQ01000002_gene4082	1.283e-110	384.0	COG0747@1|root,COG0747@2|Bacteria,2GNKN@201174|Actinobacteria,4EGG4@85012|Streptosporangiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS2_k127_125518_5	1385521.N803_12810	3.991e-101	338.0	COG0601@1|root,COG0601@2|Bacteria,2GM72@201174|Actinobacteria,4FGXV@85021|Intrasporangiaceae	201174|Actinobacteria	EP	ABC transporter (Permease)	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS2_k127_125518_6	1120950.KB892709_gene4170	2.391e-94	330.0	COG1173@1|root,COG1173@2|Bacteria,2GKAW@201174|Actinobacteria,4DPB4@85009|Propionibacteriales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS2_k127_125518_2	28444.JODQ01000002_gene4079	2.781e-120	409.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4EFQW@85012|Streptosporangiales	201174|Actinobacteria	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_125518_1	1463921.JODF01000021_gene3287	5.888e-122	419.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_125518_0	1298863.AUEP01000008_gene1263	3.018e-185	604.0	COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria,4DQAW@85009|Propionibacteriales	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
TLS2_k127_1277082_2	1146883.BLASA_2916	1.69e-120	409.0	COG0842@1|root,COG0842@2|Bacteria,2I5GM@201174|Actinobacteria	201174|Actinobacteria	V	Transport permease protein	drrB	-	-	ko:K01992,ko:K18233	ko02010,map02010	M00254,M00634	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	3.A.1,3.A.1.105.2	-	-	ABC2_membrane
TLS2_k127_1277082_1	1123024.AUII01000025_gene2106	7.351e-158	505.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DXJD@85010|Pseudonocardiales	201174|Actinobacteria	V	Daunorubicin resistance ABC transporter ATP-binding subunit	drrA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS2_k127_1277082_0	266117.Rxyl_0336	1.47e-228	716.0	COG3391@1|root,COG3391@2|Bacteria,2I9U0@201174|Actinobacteria,4CSKA@84995|Rubrobacteria	84995|Rubrobacteria	S	56kDa selenium binding protein (SBP56)	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
TLS2_k127_1277082_3	709986.Deima_0333	3.857e-39	153.0	2AI77@1|root,318MJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1303955_9	269797.Mbar_A3152	1.973e-09	65.0	COG1413@1|root,arCOG03375@2157|Archaea	2157|Archaea	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1303955_6	929556.Solca_3604	1.801e-34	144.0	2DQHD@1|root,32UP4@2|Bacteria,4NTMT@976|Bacteroidetes,1IVY3@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1303955_7	219305.MCAG_04555	8.56e-14	73.0	2DRBI@1|root,33B4D@2|Bacteria,2GWXK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1303955_2	479434.Sthe_0104	2.01e-88	302.0	COG4447@1|root,COG4447@2|Bacteria,2G8DW@200795|Chloroflexi,27YX3@189775|Thermomicrobia	189775|Thermomicrobia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1303955_0	290397.Adeh_0925	4.107e-135	451.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria,2YZ4W@29|Myxococcales	28221|Deltaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS2_k127_1303955_3	882083.SacmaDRAFT_2577	1.419e-83	287.0	COG0508@1|root,COG0508@2|Bacteria,2I8Q8@201174|Actinobacteria,4E7H1@85010|Pseudonocardiales	201174|Actinobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh
TLS2_k127_1303955_5	929712.KI912613_gene2233	1.378e-48	192.0	COG0392@1|root,COG0392@2|Bacteria,2HNI1@201174|Actinobacteria,4CPH1@84995|Rubrobacteria	84995|Rubrobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
TLS2_k127_1303955_8	265729.GS18_0218500	2.715e-13	74.0	COG0745@1|root,COG0745@2|Bacteria,1TSWT@1239|Firmicutes,4HGB5@91061|Bacilli,1ZMQB@1386|Bacillus	91061|Bacilli	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_1303955_1	552811.Dehly_0104	9.176e-116	387.0	COG0008@1|root,COG0008@2|Bacteria,2G5WU@200795|Chloroflexi,34D8Y@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS2_k127_1303955_4	1283299.AUKG01000002_gene4816	3.812e-76	264.0	COG0648@1|root,COG0648@2|Bacteria,2GJJQ@201174|Actinobacteria,4CP9J@84995|Rubrobacteria	84995|Rubrobacteria	L	AP endonuclease family 2	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
TLS2_k127_1326683_1	469383.Cwoe_2928	1.248e-147	472.0	COG0466@1|root,COG0466@2|Bacteria,2GK9D@201174|Actinobacteria,4CPRA@84995|Rubrobacteria	84995|Rubrobacteria	O	Lon protease (S16) C-terminal proteolytic domain	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS2_k127_1326683_5	266117.Rxyl_0906	5.62e-16	82.0	COG1733@1|root,COG1733@2|Bacteria,2IQWP@201174|Actinobacteria,4CQQK@84995|Rubrobacteria	84995|Rubrobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS2_k127_1326683_4	1122622.ATWJ01000010_gene1263	1.026e-21	111.0	COG0028@1|root,COG3291@1|root,COG0028@2|Bacteria,COG3291@2|Bacteria,2I5PU@201174|Actinobacteria	201174|Actinobacteria	M	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PA,Peptidase_M36
TLS2_k127_1326683_0	356851.JOAN01000035_gene1957	1.18e-233	748.0	COG2866@1|root,COG2866@2|Bacteria,2GJ8D@201174|Actinobacteria,4D9AF@85008|Micromonosporales	201174|Actinobacteria	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS2_k127_1326683_2	469383.Cwoe_0656	3.355e-82	283.0	COG0583@1|root,COG0583@2|Bacteria,2GM99@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_1369072_0	1283299.AUKG01000001_gene1533	9.538e-64	241.0	COG2199@1|root,COG5000@1|root,COG3706@2|Bacteria,COG5000@2|Bacteria,2IA4H@201174|Actinobacteria,4CP5Q@84995|Rubrobacteria	84995|Rubrobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HAMP
TLS2_k127_1369072_1	1385519.N801_16220	4.401e-37	150.0	COG1266@1|root,COG1266@2|Bacteria,2IAIM@201174|Actinobacteria	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS2_k127_1385156_5	266117.Rxyl_2032	5.689e-85	299.0	COG0683@1|root,COG0683@2|Bacteria,2GM00@201174|Actinobacteria,4CPCG@84995|Rubrobacteria	84995|Rubrobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_1385156_4	1121946.AUAX01000024_gene7587	1.152e-90	310.0	COG0559@1|root,COG0559@2|Bacteria,2GMAY@201174|Actinobacteria,4D95X@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_1385156_1	266117.Rxyl_2030	3.584e-103	351.0	COG4177@1|root,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria,4CPB4@84995|Rubrobacteria	84995|Rubrobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_1385156_2	525904.Tter_0588	5.369e-100	344.0	COG0411@1|root,COG0411@2|Bacteria,2NNYG@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_1385156_3	1380390.JIAT01000016_gene5600	3.479e-96	333.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4CPPE@84995|Rubrobacteria	84995|Rubrobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_1385156_0	867903.ThesuDRAFT_02138	1.241e-189	621.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,3WCFG@538999|Clostridiales incertae sedis	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
TLS2_k127_149544_1	1380390.JIAT01000014_gene6100	2.643e-114	381.0	COG0053@1|root,COG0053@2|Bacteria,2GJ8Q@201174|Actinobacteria,4CPB0@84995|Rubrobacteria	84995|Rubrobacteria	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TLS2_k127_149544_8	469383.Cwoe_1610	6.627e-34	134.0	COG0278@1|root,COG0278@2|Bacteria,2HR8V@201174|Actinobacteria,4CT56@84995|Rubrobacteria	84995|Rubrobacteria	O	Glutaredoxin	-	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
TLS2_k127_149544_13	533240.CRC_00290	1.565e-11	73.0	COG0271@1|root,COG0271@2|Bacteria,1G7V3@1117|Cyanobacteria,1HPHF@1161|Nostocales	1117|Cyanobacteria	T	Belongs to the BolA IbaG family	colA	-	-	-	-	-	-	-	-	-	-	-	BolA
TLS2_k127_149544_6	469383.Cwoe_4330	1.978e-34	151.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,4CR97@84995|Rubrobacteria	84995|Rubrobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_149544_9	1123248.KB893386_gene1929	2.016e-26	113.0	COG3467@1|root,COG3467@2|Bacteria,4NQFR@976|Bacteroidetes,1ITPB@117747|Sphingobacteriia	976|Bacteroidetes	S	SPTR Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
TLS2_k127_149544_7	469383.Cwoe_3472	4.239e-34	147.0	COG3118@1|root,COG3118@2|Bacteria,2GJ7B@201174|Actinobacteria	201174|Actinobacteria	O	Thioredoxin	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
TLS2_k127_149544_10	1162668.LFE_1240	2.94e-26	118.0	COG1765@1|root,COG1765@2|Bacteria	1162668.LFE_1240|-	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_149544_14	2045.KR76_07190	2.825e-05	57.0	COG0607@1|root,COG0607@2|Bacteria,2IKTC@201174|Actinobacteria,4DSBR@85009|Propionibacteriales	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS2_k127_149544_12	1382306.JNIM01000001_gene3599	6.857e-19	95.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS2_k127_149544_11	1144275.COCOR_05483	4.391e-19	98.0	COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	3.2.1.17	ko:K01185,ko:K17733	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	CHAP,NLPC_P60,PG_binding_1,Phage_lysozyme
TLS2_k127_149544_3	266117.Rxyl_0115	8.17e-97	327.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4CRRF@84995|Rubrobacteria	84995|Rubrobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS2_k127_149544_0	1068978.AMETH_1118	1.784e-114	381.0	COG0714@1|root,COG0714@2|Bacteria,2HRDU@201174|Actinobacteria,4EAJK@85010|Pseudonocardiales	201174|Actinobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
TLS2_k127_149544_4	502025.Hoch_2002	1.458e-85	297.0	COG1319@1|root,COG1319@2|Bacteria,1PG5C@1224|Proteobacteria,43EJH@68525|delta/epsilon subdivisions,2X9UI@28221|Deltaproteobacteria,2Z2GS@29|Myxococcales	28221|Deltaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_149544_5	675635.Psed_2653	6.633e-70	245.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria,4E2ZA@85010|Pseudonocardiales	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_149544_2	502025.Hoch_2000	8.532e-106	360.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
TLS2_k127_1526276_0	1192034.CAP_6873	4.195e-95	323.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2WJ90@28221|Deltaproteobacteria,2YTZN@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1162	THF_DHG_CYH,THF_DHG_CYH_C
TLS2_k127_1526276_3	1283283.ATXA01000006_gene1916	3.415e-23	101.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria,4ETDM@85013|Frankiales	201174|Actinobacteria	K	Cold shock protein	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_1526276_2	1118054.CAGW01000056_gene2096	1.509e-25	108.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,4HNNA@91061|Bacilli,26ZAP@186822|Paenibacillaceae	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
TLS2_k127_1526276_1	313589.JNB_19203	3.884e-43	164.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4FFVV@85021|Intrasporangiaceae	201174|Actinobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_1562805_0	525904.Tter_2623	4.31e-240	759.0	COG1060@1|root,COG1060@2|Bacteria,2NP8W@2323|unclassified Bacteria	2|Bacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	fbiC	-	1.21.98.1,2.5.1.77	ko:K11779,ko:K11784	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396	RC01381,RC02329,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC,Radical_SAM
TLS2_k127_1562805_6	1122611.KB903965_gene5012	9.191e-42	157.0	COG3467@1|root,COG3467@2|Bacteria,2IQIK@201174|Actinobacteria,4EK1T@85012|Streptosporangiales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_1562805_4	1394178.AWOO02000001_gene1500	3.066e-162	520.0	COG2141@1|root,COG2141@2|Bacteria,2GJ04@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
TLS2_k127_1562805_7	1394178.AWOO02000001_gene1497	3.071e-16	92.0	28RGR@1|root,2ZDVS@2|Bacteria,2GR2V@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1562805_1	1394178.AWOO02000001_gene1496	2.373e-220	718.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4EFSX@85012|Streptosporangiales	201174|Actinobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.2.4	ko:K00102,ko:K11472	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_1562805_2	1394178.AWOO02000001_gene1495	2.133e-204	643.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria,4EH4E@85012|Streptosporangiales	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
TLS2_k127_1562805_5	937777.Deipe_2283	3.394e-109	362.0	COG0624@1|root,COG0624@2|Bacteria,1WKXT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Peptidase family M28	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_M20
TLS2_k127_159120_3	469383.Cwoe_0762	3.425e-50	185.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	sigV	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_159120_2	69395.JQLZ01000004_gene888	4.818e-101	340.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2TR5R@28211|Alphaproteobacteria,2KG5S@204458|Caulobacterales	204458|Caulobacterales	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
TLS2_k127_159120_1	1246995.AFR_17095	9.219e-102	361.0	COG0477@1|root,COG2814@2|Bacteria,2GJPT@201174|Actinobacteria,4DDBJ@85008|Micromonosporales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	ko:K18215	-	-	-	-	ko00000,ko01504,ko02000	2.A.1.21.3	-	-	MFS_1,MFS_3
TLS2_k127_159120_0	35754.JNYJ01000007_gene2861	7.876e-109	387.0	COG0477@1|root,COG2814@2|Bacteria,2GJPT@201174|Actinobacteria,4DDBJ@85008|Micromonosporales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	ko:K18215	-	-	-	-	ko00000,ko01504,ko02000	2.A.1.21.3	-	-	MFS_1,MFS_3
TLS2_k127_159120_5	1211115.ALIQ01000110_gene1154	4.429e-37	145.0	COG3157@1|root,COG3157@2|Bacteria,1RBTU@1224|Proteobacteria,2U1NF@28211|Alphaproteobacteria,3NBIR@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Type VI secretion system effector, Hcp	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
TLS2_k127_1642303_2	1452536.JARE01000047_gene2534	1.282e-45	174.0	COG0611@1|root,COG0611@2|Bacteria,2GP6E@201174|Actinobacteria,4FKD1@85023|Microbacteriaceae	201174|Actinobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0008150,GO:0040007	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2977c	AIRS,AIRS_C
TLS2_k127_1642303_3	1906.SFRA_06160	3.589e-40	165.0	COG3245@1|root,COG3245@2|Bacteria,2IGG3@201174|Actinobacteria	201174|Actinobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1642303_5	398512.JQKC01000010_gene88	2.282e-08	65.0	COG0668@1|root,COG0668@2|Bacteria,1TR9Z@1239|Firmicutes,24CAG@186801|Clostridia,3WJT0@541000|Ruminococcaceae	186801|Clostridia	M	mechanosensitive ion channel	mscS	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K16052,ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3,1.A.23.4	-	-	MS_channel
TLS2_k127_1642303_4	555079.Toce_0060	2.362e-36	140.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,42GS3@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS2_k127_1642303_1	290397.Adeh_2624	1.579e-83	286.0	COG1216@1|root,COG1216@2|Bacteria,1QX3U@1224|Proteobacteria,42RP8@68525|delta/epsilon subdivisions,2WNF5@28221|Deltaproteobacteria,2Z30X@29|Myxococcales	28221|Deltaproteobacteria	S	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
TLS2_k127_1642303_0	1283299.AUKG01000001_gene1959	1.992e-146	483.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2GMFH@201174|Actinobacteria,4CPMF@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA polymerase X	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
TLS2_k127_166165_8	266117.Rxyl_1702	4.033e-15	79.0	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4CPMC@84995|Rubrobacteria	84995|Rubrobacteria	I	Biotin carboxylase C-terminal domain	-	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
TLS2_k127_166165_6	266117.Rxyl_2415	1.507e-78	270.0	COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria,4CQ3X@84995|Rubrobacteria	84995|Rubrobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_166165_4	266117.Rxyl_2045	1.921e-84	284.0	COG0693@1|root,COG0693@2|Bacteria,2GMMW@201174|Actinobacteria,4CPWN@84995|Rubrobacteria	84995|Rubrobacteria	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
TLS2_k127_166165_5	266117.Rxyl_1226	7.151e-84	296.0	COG2271@1|root,COG2271@2|Bacteria,2I4BI@201174|Actinobacteria,4CPZW@84995|Rubrobacteria	84995|Rubrobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
TLS2_k127_166165_7	795955.AFRW01000024_gene2300	5.142e-61	224.0	COG1820@1|root,COG1820@2|Bacteria,2GK1E@201174|Actinobacteria,1W8SZ@1268|Micrococcaceae	201174|Actinobacteria	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3332	Amidohydro_1
TLS2_k127_166165_1	1380390.JIAT01000010_gene4343	5.825e-105	358.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4CPVK@84995|Rubrobacteria	84995|Rubrobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	-	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS2_k127_166165_0	469383.Cwoe_0232	3.234e-151	509.0	COG1960@1|root,COG1960@2|Bacteria,2GMEM@201174|Actinobacteria,4CPRK@84995|Rubrobacteria	84995|Rubrobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_166165_2	67373.JOBF01000013_gene4018	1.233e-100	344.0	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
TLS2_k127_166165_3	469383.Cwoe_4647	8.837e-87	293.0	COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria,4CQB3@84995|Rubrobacteria	84995|Rubrobacteria	E	LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS2_k127_1703251_0	643648.Slip_1920	7.076e-11	74.0	COG4753@1|root,COG4963@1|root,COG4753@2|Bacteria,COG4963@2|Bacteria,1UF2S@1239|Firmicutes,248CD@186801|Clostridia,42KK8@68298|Syntrophomonadaceae	186801|Clostridia	D	PFAM response regulator receiver	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,Response_reg
TLS2_k127_1703251_1	930171.Asphe3_27760	1.131e-08	65.0	COG3745@1|root,COG3745@2|Bacteria,2INHS@201174|Actinobacteria	201174|Actinobacteria	U	Pilus assembly protein	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
TLS2_k127_1703251_4	1121127.JAFA01000003_gene2054	0.000603	53.0	COG4961@1|root,COG4961@2|Bacteria,1RKE7@1224|Proteobacteria,2VZN3@28216|Betaproteobacteria,1K3TC@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Putative Tad-like Flp pilus-assembly	-	-	-	-	-	-	-	-	-	-	-	-	Tad,Tad_C
TLS2_k127_1703251_2	290340.AAur_2908	2.506e-08	61.0	COG4961@1|root,COG4961@2|Bacteria,2GWMA@201174|Actinobacteria	201174|Actinobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS2_k127_1703251_3	291985.CCSI01000001_gene2052	0.0004045	50.0	COG3847@1|root,COG3847@2|Bacteria,1Q1G3@1224|Proteobacteria,2V11R@28211|Alphaproteobacteria,2K7TI@204457|Sphingomonadales	204457|Sphingomonadales	U	Flp pilus assembly protein, pilin Flp	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
TLS2_k127_171096_2	1380347.JNII01000006_gene1902	2.03e-86	309.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
TLS2_k127_171096_0	1380347.JNII01000006_gene1903	2.536e-110	370.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4EV42@85013|Frankiales	201174|Actinobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS2_k127_171096_4	1298863.AUEP01000001_gene814	1.522e-45	177.0	COG1475@1|root,COG1475@2|Bacteria,2IAI6@201174|Actinobacteria	201174|Actinobacteria	K	DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
TLS2_k127_171096_1	1206741.BAFX01000081_gene6244	1.193e-97	327.0	COG1073@1|root,COG1073@2|Bacteria,2GNB6@201174|Actinobacteria,4FVFM@85025|Nocardiaceae	201174|Actinobacteria	L	Alpha Beta	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,DLH,Hydrolase_4,Peptidase_S15
TLS2_k127_171096_3	35754.JNYJ01000016_gene9287	2.982e-57	205.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4DF11@85008|Micromonosporales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_1761019_4	469383.Cwoe_5792	2.335e-72	251.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4CPU9@84995|Rubrobacteria	84995|Rubrobacteria	L	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
TLS2_k127_1761019_6	438753.AZC_1301	1.131e-47	195.0	COG2730@1|root,COG2730@2|Bacteria,1QU12@1224|Proteobacteria,2TYN6@28211|Alphaproteobacteria,3F11R@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	CBD_II	-	-	3.2.1.14,3.2.1.4	ko:K01179,ko:K01183	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R01206,R02334,R06200,R11307,R11308	RC00467	ko00000,ko00001,ko01000	-	GH18,GH5,GH9	-	CBM_2,Calx-beta,Cellulase
TLS2_k127_1761019_5	1380390.JIAT01000009_gene2046	6.037e-52	194.0	COG0266@1|root,COG0266@2|Bacteria,2GKCW@201174|Actinobacteria,4CPYU@84995|Rubrobacteria	84995|Rubrobacteria	L	Formamidopyrimidine-DNA glycosylase H2TH domain	-	-	-	-	-	-	-	-	-	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_1761019_9	1122939.ATUD01000017_gene4008	7.288e-12	78.0	2ATZV@1|root,31JJQ@2|Bacteria,2HNRB@201174|Actinobacteria,4CPYQ@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1761019_3	1896.JOAU01000009_gene6389	3.428e-94	341.0	COG1404@1|root,COG5555@1|root,COG1404@2|Bacteria,COG5555@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,FG-GAP_2,Peptidase_S8,Trypsin
TLS2_k127_1761019_7	68223.JNZY01000001_gene5618	3.488e-46	192.0	COG3227@1|root,COG3291@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria,2GMQS@201174|Actinobacteria	201174|Actinobacteria	E	peptidase M36	-	-	-	ko:K01417	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	FTP,Peptidase_M36
TLS2_k127_1761019_8	1996.JOFO01000021_gene2510	2.191e-41	163.0	2C9IE@1|root,31AT3@2|Bacteria,2IM6M@201174|Actinobacteria,4EJKC@85012|Streptosporangiales	201174|Actinobacteria	S	Domain of unknown function (DUF4383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4383
TLS2_k127_1761019_2	469383.Cwoe_4668	1.488e-110	365.0	COG1192@1|root,COG1192@2|Bacteria,2GJX3@201174|Actinobacteria,4CPVA@84995|Rubrobacteria	84995|Rubrobacteria	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS2_k127_1761019_0	469383.Cwoe_4667	8.987e-127	422.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria,4CRHI@84995|Rubrobacteria	84995|Rubrobacteria	D	Tubulin/FtsZ family, GTPase domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsZ_C,Tubulin
TLS2_k127_1761019_1	469383.Cwoe_4666	5.949e-123	414.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4CPY9@84995|Rubrobacteria	84995|Rubrobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_1779096_3	1380390.JIAT01000010_gene3505	7.333e-38	161.0	COG0389@1|root,COG0389@2|Bacteria,2HPPZ@201174|Actinobacteria,4CR2N@84995|Rubrobacteria	84995|Rubrobacteria	L	impB/mucB/samB family	-	-	-	-	-	-	-	-	-	-	-	-	IMS
TLS2_k127_1779096_0	1380393.JHVP01000003_gene1268	4.998e-137	452.0	COG1073@1|root,COG2114@1|root,COG1073@2|Bacteria,COG2114@2|Bacteria,2IASU@201174|Actinobacteria	201174|Actinobacteria	IT	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
TLS2_k127_1779096_1	66429.JOFL01000016_gene114	1.158e-134	464.0	COG0415@1|root,COG0415@2|Bacteria,2GJXU@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the DNA photolyase family	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
TLS2_k127_1779096_5	521045.Kole_1930	1.18e-30	130.0	COG2045@1|root,COG2045@2|Bacteria,2GD5S@200918|Thermotogae	200918|Thermotogae	H	Belongs to the ComB family	comB	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
TLS2_k127_1779096_2	1122939.ATUD01000002_gene1205	1.09e-52	201.0	COG0705@1|root,COG0705@2|Bacteria,2GJYG@201174|Actinobacteria,4CQ6Z@84995|Rubrobacteria	84995|Rubrobacteria	S	Rhomboid family	-	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid
TLS2_k127_1779096_4	1385518.N798_11545	2.8e-33	144.0	COG3861@1|root,COG3861@2|Bacteria,2IQ4Y@201174|Actinobacteria,4FHS9@85021|Intrasporangiaceae	201174|Actinobacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1779096_6	709797.CSIRO_1776	2.192e-09	58.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,3JSHW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	pyruvate phosphate dikinase	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS2_k127_1820767_0	1283299.AUKG01000003_gene357	4.074e-111	377.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,4CRV6@84995|Rubrobacteria	84995|Rubrobacteria	M	CoA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS2_k127_1820767_2	1209984.BN978_01381	4.329e-15	89.0	COG2244@1|root,COG2244@2|Bacteria,2I8UT@201174|Actinobacteria,232WM@1762|Mycobacteriaceae	201174|Actinobacteria	S	membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
TLS2_k127_1820767_1	867845.KI911784_gene3417	7.74e-33	144.0	COG2723@1|root,COG2723@2|Bacteria,2GBIH@200795|Chloroflexi,3771Z@32061|Chloroflexia	32061|Chloroflexia	G	6-phospho-beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	FlaA,Glyco_hydro_42,Glyco_hydro_cc
TLS2_k127_1872070_4	469383.Cwoe_5854	7.042e-90	300.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria,4CPK3@84995|Rubrobacteria	84995|Rubrobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
TLS2_k127_1872070_6	1380390.JIAT01000014_gene6198	1e-70	245.0	COG0546@1|root,COG0546@2|Bacteria,2GIU8@201174|Actinobacteria,4CPZN@84995|Rubrobacteria	84995|Rubrobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS2_k127_1872070_0	1150864.MILUP08_42435	2.616e-126	416.0	COG0520@1|root,COG0520@2|Bacteria,2GJA4@201174|Actinobacteria,4DC2F@85008|Micromonosporales	201174|Actinobacteria	E	aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_1872070_5	913325.N799_00820	1.011e-85	308.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1X4X5@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	-	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
TLS2_k127_1872070_3	469383.Cwoe_3786	2.9e-104	355.0	COG2206@1|root,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria	201174|Actinobacteria	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HD,HD_5
TLS2_k127_1872070_2	266117.Rxyl_2251	3.196e-105	365.0	COG3938@1|root,COG3938@2|Bacteria,2GM47@201174|Actinobacteria,4CPQZ@84995|Rubrobacteria	84995|Rubrobacteria	E	Proline racemase	-	-	5.1.1.4	ko:K01777	ko00330,ko01100,map00330,map01100	-	R01255	RC00479	ko00000,ko00001,ko01000	-	-	-	Pro_racemase
TLS2_k127_1872070_7	1463920.JOGB01000012_gene6592	1.11e-56	208.0	COG0789@1|root,COG1225@1|root,COG0789@2|Bacteria,COG1225@2|Bacteria,2IIEZ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1,Redoxin
TLS2_k127_1872070_1	1123023.JIAI01000006_gene93	1.447e-122	401.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4E1WD@85010|Pseudonocardiales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	tdcA	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS2_k127_1889643_9	330214.NIDE4164	8.314e-40	154.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria	2|Bacteria	E	Formiminotransferase domain	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K01746,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
TLS2_k127_1889643_3	1183438.GKIL_2511	2.668e-160	533.0	COG2986@1|root,COG2986@2|Bacteria,1G3FJ@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Phenylalanine and histidine ammonia-lyase	hutH	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009072,GO:0009698,GO:0009699,GO:0009800,GO:0009803,GO:0009987,GO:0016043,GO:0016053,GO:0016829,GO:0016840,GO:0016841,GO:0019438,GO:0019748,GO:0019752,GO:0022607,GO:0032787,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044550,GO:0045548,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	4.3.1.24,4.3.1.3	ko:K01745,ko:K10775	ko00340,ko00360,ko00940,ko01100,ko01110,map00340,map00360,map00940,map01100,map01110	M00039,M00045,M00137,M00350	R00697,R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
TLS2_k127_1889643_0	562970.Btus_0928	5.019e-245	793.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,4H9NH@91061|Bacilli,2782U@186823|Alicyclobacillaceae	91061|Bacilli	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
TLS2_k127_1889643_4	266117.Rxyl_0585	4.885e-125	439.0	COG1228@1|root,COG1228@2|Bacteria,2GJH4@201174|Actinobacteria,4CQ30@84995|Rubrobacteria	84995|Rubrobacteria	Q	Belongs to the metallo-dependent hydrolases superfamily. HutI family	-	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS2_k127_1889643_10	469383.Cwoe_3944	3.141e-19	91.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	ko:K21700	-	-	-	-	ko00000	-	-	-	3-HAO,Cupin_2
TLS2_k127_1889643_8	1380390.JIAT01000017_gene5310	1.878e-44	175.0	COG0491@1|root,COG0491@2|Bacteria,2GJU0@201174|Actinobacteria,4CQ06@84995|Rubrobacteria	84995|Rubrobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_1889643_5	469383.Cwoe_3015	1.006e-110	381.0	COG0124@1|root,COG0124@2|Bacteria,2GIYJ@201174|Actinobacteria,4CPRI@84995|Rubrobacteria	84995|Rubrobacteria	J	PFAM tRNA synthetase, class II (G, H, P and S)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TLS2_k127_1889643_1	525146.Ddes_0010	2.112e-175	591.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2M7Y4@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TLS2_k127_1889643_11	469383.Cwoe_3477	1.858e-10	67.0	COG0797@1|root,COG0797@2|Bacteria,2GUG2@201174|Actinobacteria,4CQFM@84995|Rubrobacteria	84995|Rubrobacteria	M	Lytic transglycolase	-	-	-	-	-	-	-	-	-	-	-	-	DPBB_1
TLS2_k127_1889643_6	1242864.D187_007535	1.089e-74	269.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2WK6B@28221|Deltaproteobacteria,2YUTU@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TLS2_k127_1889643_12	1444309.JAQG01000110_gene1787	1.418e-05	55.0	COG2172@1|root,COG2172@2|Bacteria,1V1IA@1239|Firmicutes,4HM6Z@91061|Bacilli,275C6@186822|Paenibacillaceae	91061|Bacilli	T	Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)	rsbW	GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
TLS2_k127_1889643_7	469383.Cwoe_1813	1.677e-71	257.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4CSNH@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70 region 3	-	-	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_1889643_2	469383.Cwoe_3034	3.268e-166	535.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4CPQA@84995|Rubrobacteria	84995|Rubrobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS2_k127_1906485_7	562970.Btus_1404	4.879e-28	124.0	COG0697@1|root,COG0697@2|Bacteria,1TSKX@1239|Firmicutes,4HBPE@91061|Bacilli,278SE@186823|Alicyclobacillaceae	91061|Bacilli	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_1906485_4	305900.GV64_24450	9.788e-41	174.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HCBP_related,He_PIG,HemolysinCabind
TLS2_k127_1906485_0	1123065.ATWL01000014_gene3494	2.165e-133	431.0	COG0053@1|root,COG0053@2|Bacteria,2GKSG@201174|Actinobacteria	201174|Actinobacteria	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TLS2_k127_1906485_5	153948.NAL212_1118	1.165e-39	165.0	28MCN@1|root,2ZAQR@2|Bacteria,1N00X@1224|Proteobacteria,2VV0N@28216|Betaproteobacteria,373FE@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1906485_1	1385518.N798_07540	6.317e-100	335.0	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,4FIGZ@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_1906485_9	68260.JOAY01000025_gene1182	0.0005953	46.0	2906U@1|root,2ZMWM@2|Bacteria,2IT05@201174|Actinobacteria	201174|Actinobacteria	S	Lipopolysaccharide assembly protein A domain	-	-	-	-	-	-	-	-	-	-	-	-	LapA_dom
TLS2_k127_1906485_3	1122939.ATUD01000001_gene478	3.439e-75	269.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4CPWE@84995|Rubrobacteria	84995|Rubrobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_1906485_8	1200792.AKYF01000006_gene1561	1.345e-12	80.0	2DZXU@1|root,32VMR@2|Bacteria,1VBBV@1239|Firmicutes,4HPWN@91061|Bacilli,26ZA3@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1906485_2	66874.JOFS01000020_gene5622	1.578e-97	340.0	COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_1906485_6	644283.Micau_2838	4.637e-38	145.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4DA8Z@85008|Micromonosporales	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_1914704_29	1463879.JOHP01000023_gene3936	1.594e-15	86.0	COG0662@1|root,COG0662@2|Bacteria,2ICZ9@201174|Actinobacteria	201174|Actinobacteria	G	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Cupin_2
TLS2_k127_1914704_27	1283299.AUKG01000005_gene155	2.03e-22	106.0	COG0662@1|root,COG0662@2|Bacteria,2HR0E@201174|Actinobacteria,4CSU6@84995|Rubrobacteria	84995|Rubrobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_1914704_0	1380390.JIAT01000010_gene3508	0.0	1107.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CPV2@84995|Rubrobacteria	84995|Rubrobacteria	L	Helix-hairpin-helix motif	-	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
TLS2_k127_1914704_24	1499967.BAYZ01000090_gene4945	5.197e-33	151.0	COG0823@1|root,COG1807@1|root,COG0823@2|Bacteria,COG1807@2|Bacteria,2NPHZ@2323|unclassified Bacteria	2|Bacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641,ko:K08676	-	-	-	-	ko00000,ko01000,ko01002,ko02000	2.C.1.2	-	-	PD40,PMT_2,Peptidase_S41,Tricorn_C1
TLS2_k127_1914704_1	469383.Cwoe_3388	1.682e-242	769.0	COG1366@1|root,COG2409@1|root,COG1366@2|Bacteria,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4CR8Y@84995|Rubrobacteria	84995|Rubrobacteria	T	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	MMPL,STAS_2
TLS2_k127_1914704_13	1380390.JIAT01000011_gene2689	5.419e-63	234.0	COG2211@1|root,COG2211@2|Bacteria,2HPVX@201174|Actinobacteria,4CRAI@84995|Rubrobacteria	84995|Rubrobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_1914704_9	469383.Cwoe_3717	3.997e-86	289.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_1914704_10	67275.JOAP01000049_gene834	3.66e-80	274.0	COG0454@1|root,COG0456@2|Bacteria,2GK76@201174|Actinobacteria	201174|Actinobacteria	K	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_1914704_4	1380390.JIAT01000010_gene4195	1.405e-98	352.0	COG4585@1|root,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria,4CSC0@84995|Rubrobacteria	84995|Rubrobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS2_k127_1914704_20	1283299.AUKG01000002_gene4673	2.25e-41	160.0	COG2197@1|root,COG2197@2|Bacteria,2I5RT@201174|Actinobacteria,4CST9@84995|Rubrobacteria	84995|Rubrobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_1914704_7	1380390.JIAT01000010_gene4086	8.986e-93	327.0	COG1801@1|root,COG1801@2|Bacteria,2GMSP@201174|Actinobacteria,4CQ1B@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS2_k127_1914704_5	469383.Cwoe_5524	7.242e-96	322.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4CS0Z@84995|Rubrobacteria	84995|Rubrobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_1914704_16	101510.RHA1_ro00029	4.908e-49	199.0	COG1668@1|root,COG1668@2|Bacteria,2I510@201174|Actinobacteria,4G9JJ@85025|Nocardiaceae	201174|Actinobacteria	CP	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
TLS2_k127_1914704_31	1283299.AUKG01000001_gene1490	3.091e-13	83.0	COG3021@1|root,COG3021@2|Bacteria,2HQIN@201174|Actinobacteria,4CS44@84995|Rubrobacteria	84995|Rubrobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_1914704_12	469383.Cwoe_1584	4.588e-65	245.0	COG0520@1|root,COG0520@2|Bacteria,2HP42@201174|Actinobacteria,4CQF7@84995|Rubrobacteria	84995|Rubrobacteria	E	Aminotransferase class-V	-	-	-	ko:K11325	-	-	-	-	ko00000	-	-	-	Aminotran_5
TLS2_k127_1914704_21	469383.Cwoe_3625	7.846e-38	164.0	2E3FZ@1|root,32YET@2|Bacteria,2IGAC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1914704_15	644966.Tmar_1412	1.507e-56	214.0	COG2316@1|root,COG2316@2|Bacteria,1TSF7@1239|Firmicutes,24A1B@186801|Clostridia,3WDH1@538999|Clostridiales incertae sedis	186801|Clostridia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
TLS2_k127_1914704_3	861299.J421_3183	1.004e-156	508.0	COG0766@1|root,COG0766@2|Bacteria,1ZSZ5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TLS2_k127_1914704_23	479434.Sthe_1579	6.339e-36	142.0	COG0251@1|root,COG0251@2|Bacteria,2G6XT@200795|Chloroflexi,27YDZ@189775|Thermomicrobia	189775|Thermomicrobia	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
TLS2_k127_1914704_2	635013.TherJR_1640	1.542e-157	531.0	COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,260EB@186807|Peptococcaceae	186801|Clostridia	J	tRNA nucleotidyltransferase poly(A) polymerase	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
TLS2_k127_1914704_22	643562.Daes_2473	4.067e-37	163.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,42STM@68525|delta/epsilon subdivisions,2WPAD@28221|Deltaproteobacteria,2MB8X@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
TLS2_k127_1914704_17	483219.LILAB_22735	1.153e-48	191.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,42SE9@68525|delta/epsilon subdivisions,2WMQE@28221|Deltaproteobacteria,2YVJ7@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
TLS2_k127_1914704_18	469383.Cwoe_3523	3.723e-48	186.0	COG0325@1|root,COG0325@2|Bacteria,2GMRJ@201174|Actinobacteria,4CQAV@84995|Rubrobacteria	84995|Rubrobacteria	S	Alanine racemase, N-terminal domain	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
TLS2_k127_1914704_14	469383.Cwoe_3522	3.957e-57	207.0	COG1799@1|root,COG1799@2|Bacteria,2GNVH@201174|Actinobacteria,4CQ0C@84995|Rubrobacteria	84995|Rubrobacteria	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	-	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
TLS2_k127_1914704_32	1122939.ATUD01000019_gene1542	1.06e-11	68.0	COG0762@1|root,COG0762@2|Bacteria,2HR5Q@201174|Actinobacteria,4CT15@84995|Rubrobacteria	84995|Rubrobacteria	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
TLS2_k127_1914704_30	292459.STH1230	1.715e-15	83.0	COG3599@1|root,COG3599@2|Bacteria,1V27M@1239|Firmicutes,24MM3@186801|Clostridia	186801|Clostridia	D	PFAM DivIVA family protein	divIVA	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
TLS2_k127_1914704_28	373903.Hore_09300	4.999e-19	92.0	COG1734@1|root,COG1734@2|Bacteria,1V6MF@1239|Firmicutes,24K3N@186801|Clostridia,3WBSX@53433|Halanaerobiales	186801|Clostridia	T	PFAM Prokaryotic dksA traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
TLS2_k127_1914704_25	469383.Cwoe_3519	1.298e-25	117.0	COG0597@1|root,COG0597@2|Bacteria,2HP4E@201174|Actinobacteria,4CQFY@84995|Rubrobacteria	84995|Rubrobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
TLS2_k127_1914704_6	1380390.JIAT01000010_gene4530	4.631e-93	315.0	COG0564@1|root,COG0564@2|Bacteria,2GIY1@201174|Actinobacteria,4CQ1Y@84995|Rubrobacteria	84995|Rubrobacteria	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_1914704_26	1283299.AUKG01000001_gene2230	2.126e-25	118.0	COG2199@1|root,COG3706@2|Bacteria,2HFR8@201174|Actinobacteria,4CRCW@84995|Rubrobacteria	84995|Rubrobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF,PAS_8
TLS2_k127_1914704_8	1209989.TepiRe1_1365	4.47e-87	299.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,247ZR@186801|Clostridia,42ENB@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
TLS2_k127_1914704_19	741091.Rahaq_0864	5.17e-47	193.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,3FG4B@34037|Rahnella	1236|Gammaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0019899,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051020,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
TLS2_k127_1914704_11	469383.Cwoe_3515	1.132e-75	259.0	COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4CPH9@84995|Rubrobacteria	84995|Rubrobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS2_k127_1923684_1	1122939.ATUD01000016_gene1821	3.631e-59	223.0	COG2723@1|root,COG2723@2|Bacteria,2HFEG@201174|Actinobacteria,4CRFZ@84995|Rubrobacteria	2|Bacteria	G	6-phospho-beta-galactosidase activity	-	-	-	ko:K21000	ko02025,map02025	-	-	-	ko00000,ko00001	-	GH39	-	Cellulase
TLS2_k127_1923684_2	1122939.ATUD01000016_gene1821	5.145e-58	219.0	COG2723@1|root,COG2723@2|Bacteria,2HFEG@201174|Actinobacteria,4CRFZ@84995|Rubrobacteria	2|Bacteria	G	6-phospho-beta-galactosidase activity	-	-	-	ko:K21000	ko02025,map02025	-	-	-	ko00000,ko00001	-	GH39	-	Cellulase
TLS2_k127_1923684_0	760568.Desku_3528	1.825e-90	302.0	COG1089@1|root,COG1089@2|Bacteria,1TQ9T@1239|Firmicutes,24863@186801|Clostridia,263QH@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_1941771_5	292459.STH1415	1.909e-41	172.0	COG0159@1|root,COG0159@2|Bacteria,1TPXA@1239|Firmicutes,248M2@186801|Clostridia	186801|Clostridia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
TLS2_k127_1941771_0	211165.AJLN01000116_gene2986	1.31e-144	484.0	COG0133@1|root,COG0133@2|Bacteria,1G0SQ@1117|Cyanobacteria,1JHAN@1189|Stigonemataceae	1117|Cyanobacteria	E	Pyridoxal-phosphate dependent enzyme	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_1941771_4	448385.sce1101	4e-43	180.0	COG0134@1|root,COG0135@1|root,COG0134@2|Bacteria,COG0135@2|Bacteria,1MW5K@1224|Proteobacteria,42MAG@68525|delta/epsilon subdivisions,2WM94@28221|Deltaproteobacteria,2YV8U@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the TrpC family	trpC	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2494	IGPS
TLS2_k127_1941771_1	1121468.AUBR01000014_gene2225	2.875e-104	362.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,42EK5@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TLS2_k127_1941771_3	429009.Adeg_1161	5.073e-61	229.0	COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,24FR0@186801|Clostridia,42G1H@68295|Thermoanaerobacterales	186801|Clostridia	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS2_k127_1941771_2	498761.HM1_1916	9.867e-88	298.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia	186801|Clostridia	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	2.6.1.85,4.1.3.27,4.1.3.38	ko:K01657,ko:K01665,ko:K03342,ko:K13503,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716,R05553	RC00010,RC01418,RC01843,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS2_k127_1961927_7	1304880.JAGB01000001_gene527	4.86e-43	173.0	COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,1TT2K@1239|Firmicutes,24965@186801|Clostridia	186801|Clostridia	M	Peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM,NLPC_P60,PG_binding_1
TLS2_k127_1961927_6	5062.CADAORAP00002191	4.499e-43	177.0	2EBE9@1|root,2SHHH@2759|Eukaryota,3AEYE@33154|Opisthokonta,3PB61@4751|Fungi,3R2BK@4890|Ascomycota	4751|Fungi	S	Domain of unknown function (DUF4111)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4111,NTP_transf_2
TLS2_k127_1961927_5	880073.Calab_3265	1.168e-52	211.0	COG0432@1|root,COG0432@2|Bacteria,2NPB7@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TLS2_k127_1961927_11	1122221.JHVI01000002_gene787	1.255e-11	76.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase
TLS2_k127_1961927_12	926569.ANT_02430	0.0006268	50.0	2A1JS@1|root,30PTP@2|Bacteria,2G9H1@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1961927_3	266117.Rxyl_0836	7.416e-109	376.0	COG0075@1|root,COG0075@2|Bacteria,2GM5F@201174|Actinobacteria,4CQFE@84995|Rubrobacteria	84995|Rubrobacteria	E	Aminotransferase, class V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TLS2_k127_1961927_0	469383.Cwoe_3561	2.101e-143	492.0	COG0111@1|root,COG0111@2|Bacteria,2GJGA@201174|Actinobacteria,4CP5W@84995|Rubrobacteria	84995|Rubrobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
TLS2_k127_1961927_10	1158050.KB895454_gene1321	1.684e-23	106.0	COG2606@1|root,COG2606@2|Bacteria,2IKUX@201174|Actinobacteria,1WBDG@1268|Micrococcaceae	201174|Actinobacteria	S	Aminoacyl-tRNA editing domain	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
TLS2_k127_1961927_8	266117.Rxyl_0142	1.676e-42	162.0	COG1764@1|root,COG1764@2|Bacteria,2IFFB@201174|Actinobacteria,4CQIW@84995|Rubrobacteria	84995|Rubrobacteria	O	OsmC-like protein	-	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
TLS2_k127_1961927_2	1313172.YM304_13000	1.412e-114	382.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4CMVG@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS2_k127_1961927_9	479431.Namu_0023	9.939e-36	139.0	2BG65@1|root,32A2Y@2|Bacteria,2IRVF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1961927_4	1187851.A33M_2337	3.776e-74	260.0	COG2094@1|root,COG2094@2|Bacteria,1RE0A@1224|Proteobacteria,2U7N6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the DNA glycosylase MPG family	-	GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
TLS2_k127_1961927_1	469383.Cwoe_3542	4.378e-120	409.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4CPUU@84995|Rubrobacteria	84995|Rubrobacteria	M	glycosyl transferase, family 51	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS2_k127_1966370_0	1380390.JIAT01000011_gene2348	2.388e-171	551.0	COG1366@1|root,COG2409@1|root,COG1366@2|Bacteria,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4CR8Y@84995|Rubrobacteria	84995|Rubrobacteria	T	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	MMPL,STAS_2
TLS2_k127_1966370_1	1120950.KB892805_gene1511	6.459e-26	124.0	COG1073@1|root,COG1073@2|Bacteria,2IPVI@201174|Actinobacteria	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_197777_20	526227.Mesil_2065	4.788e-09	59.0	COG1309@1|root,COG1309@2|Bacteria,1WI7P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_C_5,TetR_N
TLS2_k127_197777_13	67267.JNXT01000045_gene6252	1.178e-32	141.0	COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria	201174|Actinobacteria	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS2_k127_197777_2	469383.Cwoe_2191	1.167e-138	450.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4CT3Y@84995|Rubrobacteria	84995|Rubrobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS2_k127_197777_1	469383.Cwoe_2192	9.24e-157	501.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4CPUE@84995|Rubrobacteria	201174|Actinobacteria	C	PFAM Transketolase central region	pdhB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2496c	Transket_pyr,Transketolase_C
TLS2_k127_197777_4	469383.Cwoe_2193	7.096e-116	385.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria	201174|Actinobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_197777_12	84531.JMTZ01000038_gene3588	9.683e-36	143.0	2EFPP@1|root,339FP@2|Bacteria,1NA60@1224|Proteobacteria,1SH3I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
TLS2_k127_197777_19	1514668.JOOA01000002_gene1531	3.605e-11	67.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,3WJVA@541000|Ruminococcaceae	186801|Clostridia	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS2_k127_197777_6	1382356.JQMP01000003_gene2308	1.649e-97	326.0	COG0616@1|root,COG0616@2|Bacteria,2G635@200795|Chloroflexi,27XH7@189775|Thermomicrobia	189775|Thermomicrobia	OU	Serine dehydrogenase proteinase	-	-	-	-	-	-	-	-	-	-	-	-	SDH_sah
TLS2_k127_197777_8	469383.Cwoe_5938	6.616e-84	316.0	COG1524@1|root,COG1524@2|Bacteria,2HNGC@201174|Actinobacteria,4CPCH@84995|Rubrobacteria	84995|Rubrobacteria	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS2_k127_197777_10	314256.OG2516_18115	1.127e-54	217.0	COG2312@1|root,COG2518@1|root,COG2312@2|Bacteria,COG2518@2|Bacteria,1MU2S@1224|Proteobacteria,2TWB5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	Erythro_esteras,PCMT,Pribosyltran
TLS2_k127_197777_14	1380390.JIAT01000009_gene1807	7.281e-28	128.0	COG2246@1|root,COG2246@2|Bacteria,2HR1U@201174|Actinobacteria,4CSWB@84995|Rubrobacteria	84995|Rubrobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
TLS2_k127_197777_5	469383.Cwoe_5936	6.102e-113	394.0	2AU3I@1|root,31JPZ@2|Bacteria,2H277@201174|Actinobacteria,4CQ2S@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_197777_15	1283299.AUKG01000001_gene1781	2.868e-27	129.0	COG5650@1|root,COG5650@2|Bacteria,2HYCN@201174|Actinobacteria,4CQKH@84995|Rubrobacteria	84995|Rubrobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
TLS2_k127_197777_9	1232410.KI421425_gene1520	2.985e-74	259.0	COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,42PCG@68525|delta/epsilon subdivisions,2WM8X@28221|Deltaproteobacteria,43TFA@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
TLS2_k127_197777_3	264732.Moth_1246	2.19e-126	411.0	COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,42EWI@68295|Thermoanaerobacterales	186801|Clostridia	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS15750	ALAD
TLS2_k127_197777_18	1283299.AUKG01000001_gene1793	6.916e-14	87.0	2AWJ7@1|root,31NFU@2|Bacteria,2HR1C@201174|Actinobacteria,4CSVI@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_197777_0	429009.Adeg_1452	4.777e-169	548.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,42F6I@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the UbiD family	-	-	4.1.1.61,4.1.1.98	ko:K03182,ko:K16239	ko00130,ko00627,ko01100,ko01110,ko01120,map00130,map00627,map01100,map01110,map01120	M00117	R01238,R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
TLS2_k127_197777_16	1122939.ATUD01000013_gene913	1.964e-24	114.0	COG0723@1|root,COG0723@2|Bacteria,2H0R5@201174|Actinobacteria,4CQW0@84995|Rubrobacteria	84995|Rubrobacteria	C	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
TLS2_k127_197777_7	469383.Cwoe_5927	9.96e-91	306.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4CQ40@84995|Rubrobacteria	84995|Rubrobacteria	C	Cytochrome b	-	-	-	ko:K03887	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_B
TLS2_k127_197777_11	1380390.JIAT01000009_gene1821	1.11e-39	156.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,2HDYV@201174|Actinobacteria,4CQSB@84995|Rubrobacteria	84995|Rubrobacteria	C	Cytochrome b subunit of the bc	-	-	-	ko:K03888	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_C,Cytochrom_C,Cytochrome_CBB3
TLS2_k127_1984303_21	365046.Rta_16690	4.392e-16	85.0	2AKF7@1|root,31B6Q@2|Bacteria,1N34J@1224|Proteobacteria,2W3YK@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1984303_19	1254432.SCE1572_35640	2.848e-36	158.0	COG1807@1|root,COG1807@2|Bacteria,1QZIN@1224|Proteobacteria,435DV@68525|delta/epsilon subdivisions,2WZRC@28221|Deltaproteobacteria,2Z2K8@29|Myxococcales	28221|Deltaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1984303_10	1122138.AQUZ01000019_gene8187	9.82e-76	277.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4DNJC@85009|Propionibacteriales	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_1984303_0	1380390.JIAT01000010_gene3856	2.29e-293	927.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4CPA7@84995|Rubrobacteria	84995|Rubrobacteria	P	heavy metal translocating P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS2_k127_1984303_12	1146883.BLASA_3356	1.037e-67	246.0	COG2372@1|root,COG2372@2|Bacteria,2GIWH@201174|Actinobacteria,4ERTR@85013|Frankiales	201174|Actinobacteria	S	response to copper ion	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_1984303_23	2002.JOEQ01000020_gene7103	4.404e-10	73.0	COG2608@1|root,COG2608@2|Bacteria,2GQK5@201174|Actinobacteria,4EKNK@85012|Streptosporangiales	201174|Actinobacteria	P	Heavy-metal-associated domain	copZ	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
TLS2_k127_1984303_2	1123320.KB889674_gene4217	3.414e-128	437.0	COG0747@1|root,COG0747@2|Bacteria,2GK4Y@201174|Actinobacteria	201174|Actinobacteria	E	Extracellular solute-binding protein, family 5	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
TLS2_k127_1984303_5	285514.JNWO01000002_gene5175	7.859e-107	356.0	COG0601@1|root,COG0601@2|Bacteria,2IBKP@201174|Actinobacteria	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_1984303_8	285514.JNWO01000002_gene5176	3.959e-86	308.0	COG1173@1|root,COG1173@2|Bacteria,2I9R8@201174|Actinobacteria	201174|Actinobacteria	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_1984303_1	330084.JNYZ01000001_gene3190	1.745e-196	633.0	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,4DYHR@85010|Pseudonocardiales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS2_k127_1984303_16	1123023.JIAI01000002_gene4760	4.126e-51	207.0	COG1028@1|root,COG1028@2|Bacteria,2I8W3@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_1984303_6	469383.Cwoe_2498	1.79e-94	335.0	COG1609@1|root,COG1609@2|Bacteria,2IDFR@201174|Actinobacteria,4CRMP@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS2_k127_1984303_3	1380391.JIAS01000004_gene2956	9.585e-120	412.0	COG4948@1|root,COG4948@2|Bacteria,1R8NF@1224|Proteobacteria,2UPFU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_1984303_17	318586.Pden_5052	1.238e-43	174.0	COG1028@1|root,COG1028@2|Bacteria,1RCWH@1224|Proteobacteria,2U83J@28211|Alphaproteobacteria,2PWUT@265|Paracoccus	28211|Alphaproteobacteria	IQ	NAD dependent epimerase/dehydratase family	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_1984303_15	469383.Cwoe_0359	2.276e-57	221.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4CSY8@84995|Rubrobacteria	84995|Rubrobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_1984303_11	469383.Cwoe_0393	5.371e-69	260.0	COG0006@1|root,COG0006@2|Bacteria,2H8N7@201174|Actinobacteria	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
TLS2_k127_1984303_4	1122138.AQUZ01000019_gene8186	3.137e-107	364.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4DNJC@85009|Propionibacteriales	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_1984303_25	512565.AMIS_4950	1.497e-08	65.0	COG1652@1|root,COG1652@2|Bacteria,2GK68@201174|Actinobacteria	201174|Actinobacteria	M	domain protein	-	-	-	ko:K21687	-	-	-	-	ko00000	-	GH23	-	LysM,Transglycosylas
TLS2_k127_1984303_18	479434.Sthe_2063	3.66e-40	156.0	COG1573@1|root,COG1573@2|Bacteria,2G8Q5@200795|Chloroflexi	200795|Chloroflexi	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_1984303_7	215803.DB30_7981	1.139e-89	310.0	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,43A1N@68525|delta/epsilon subdivisions,2X25S@28221|Deltaproteobacteria,2YYJ4@29|Myxococcales	28221|Deltaproteobacteria	IQ	NAD dependent epimerase dehydratase family protein	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_1984303_22	1283299.AUKG01000005_gene15	1.64e-12	74.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	1.8.2.1	ko:K05301	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00528	RC00168	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3
TLS2_k127_1984303_14	1313172.YM304_10970	2.121e-64	232.0	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria	201174|Actinobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
TLS2_k127_1984303_13	1283299.AUKG01000001_gene1262	1.828e-66	235.0	COG0491@1|root,COG0491@2|Bacteria,2GJ7I@201174|Actinobacteria,4CQ3N@84995|Rubrobacteria	84995|Rubrobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS2_k127_1984303_9	1283299.AUKG01000005_gene32	3.995e-76	271.0	COG0446@1|root,COG0446@2|Bacteria	2|Bacteria	Q	pyridine nucleotide-disulphide oxidoreductase	soxF	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.18.1.3,1.8.2.1,1.8.2.3	ko:K00529,ko:K05301,ko:K17229	ko00071,ko00360,ko00920,ko01100,ko01120,ko01220,map00071,map00360,map00920,map01100,map01120,map01220	M00545	R00528,R02000,R06782,R06783,R09499	RC00098,RC00168	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2,TAT_signal
TLS2_k127_1984303_20	365528.KB891215_gene2640	3.795e-19	88.0	2DKYI@1|root,30WMB@2|Bacteria,2I81T@201174|Actinobacteria,4EXIY@85013|Frankiales	201174|Actinobacteria	S	Domain of Unknown Function (DUF1206)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1206
TLS2_k127_1987347_2	1123237.Salmuc_00398	1.363e-39	156.0	COG1520@1|root,COG2911@1|root,COG2931@1|root,COG1520@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,HCBP_related,He_PIG,HemolysinCabind
TLS2_k127_1987347_1	543632.JOJL01000002_gene8201	8.069e-54	206.0	COG2020@1|root,COG2020@2|Bacteria,2IN0C@201174|Actinobacteria,4DE9J@85008|Micromonosporales	201174|Actinobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TLS2_k127_1987347_0	42256.RradSPS_1327	7.634e-120	403.0	COG0343@1|root,COG0343@2|Bacteria,2GMWY@201174|Actinobacteria,4CPB3@84995|Rubrobacteria	84995|Rubrobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
TLS2_k127_1987347_4	926692.AZYG01000048_gene2707	7.929e-19	92.0	COG1862@1|root,COG1862@2|Bacteria,1VEMC@1239|Firmicutes,24MMT@186801|Clostridia,3WAWM@53433|Halanaerobiales	186801|Clostridia	U	TIGRFAM preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TLS2_k127_1987347_3	1283299.AUKG01000002_gene5235	7.28e-28	124.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4CPTZ@84995|Rubrobacteria	84995|Rubrobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_2037765_2	1380390.JIAT01000009_gene1821	9.49e-41	160.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,2HDYV@201174|Actinobacteria,4CQSB@84995|Rubrobacteria	84995|Rubrobacteria	C	Cytochrome b subunit of the bc	-	-	-	ko:K03888	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_C,Cytochrom_C,Cytochrome_CBB3
TLS2_k127_2037765_1	469383.Cwoe_5927	4.732e-88	303.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4CQ40@84995|Rubrobacteria	84995|Rubrobacteria	C	Cytochrome b	-	-	-	ko:K03887	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_B
TLS2_k127_2037765_3	469383.Cwoe_5928	8.262e-25	115.0	COG0723@1|root,COG0723@2|Bacteria,2H0R5@201174|Actinobacteria,4CQW0@84995|Rubrobacteria	84995|Rubrobacteria	C	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
TLS2_k127_2037765_0	292459.STH1564	3.792e-121	396.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia	186801|Clostridia	H	Belongs to the UbiD family	-	-	4.1.1.61,4.1.1.98	ko:K03182,ko:K16239	ko00130,ko00627,ko01100,ko01110,ko01120,map00130,map00627,map01100,map01110,map01120	M00117	R01238,R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
TLS2_k127_2087242_8	266117.Rxyl_2620	2.524e-19	93.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,4CPA3@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,LPG_synthase_TM
TLS2_k127_2087242_1	404589.Anae109_2517	1.313e-94	320.0	COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria	1224|Proteobacteria	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009156,GO:0009161,GO:0009163,GO:0009164,GO:0009165,GO:0009167,GO:0009168,GO:0009987,GO:0015949,GO:0015950,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0032261,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iSFV_1184.SFV_1640,iSF_1195.SF1648,iSFxv_1172.SFxv_1849,iS_1188.S1780	A_deaminase
TLS2_k127_2087242_11	1121946.AUAX01000030_gene1272	1.322e-13	83.0	COG0457@1|root,COG0457@2|Bacteria,2I3MT@201174|Actinobacteria,4DMKN@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31,TPR_12,TPR_16,TPR_4,TPR_8
TLS2_k127_2087242_12	1042209.HK44_024060	0.0001156	51.0	COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,1S2DV@1236|Gammaproteobacteria,1YMH7@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
TLS2_k127_2087242_7	765420.OSCT_2281	6.829e-26	125.0	COG2909@1|root,COG2909@2|Bacteria,2G7Q4@200795|Chloroflexi,3754G@32061|Chloroflexia	32061|Chloroflexia	K	ATP-dependent transcriptional regulator, MalT-like, LuxR family	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
TLS2_k127_2087242_5	429009.Adeg_1201	7.768e-43	176.0	COG2203@1|root,COG2206@1|root,COG4936@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG4936@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia,42GDE@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HD,PAS_9,PocR
TLS2_k127_2087242_10	211114.JOEF01000022_gene5616	1.875e-14	78.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	DUF4019,GerE,Response_reg
TLS2_k127_2087242_2	929712.KI912613_gene2824	3.393e-90	310.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CS51@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_2087242_0	1380390.JIAT01000014_gene6211	4.529e-301	939.0	COG0550@1|root,COG0550@2|Bacteria,2GJU7@201174|Actinobacteria,4CPD0@84995|Rubrobacteria	84995|Rubrobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	-	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim,Toprim_Crpt
TLS2_k127_2087242_6	1329516.JPST01000028_gene3344	3.192e-32	133.0	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,4HDQR@91061|Bacilli,27C05@186824|Thermoactinomycetaceae	91061|Bacilli	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_2087242_3	1380394.JADL01000009_gene3405	1.204e-71	252.0	COG0258@1|root,COG0258@2|Bacteria,1QV40@1224|Proteobacteria	1224|Proteobacteria	L	5'-3' exonuclease	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N
TLS2_k127_2087242_4	1111069.TCCBUS3UF1_6490	1.786e-51	190.0	COG0247@1|root,COG0247@2|Bacteria,1WIZV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Fe-S oxidoreductase	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
TLS2_k127_2087242_9	1122138.AQUZ01000019_gene8186	8.06e-17	92.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4DNJC@85009|Propionibacteriales	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_2106730_0	1283299.AUKG01000001_gene2169	6.379e-172	553.0	COG1205@1|root,COG1205@2|Bacteria,2GJJ6@201174|Actinobacteria,4CPIU@84995|Rubrobacteria	84995|Rubrobacteria	L	Domain of unknown function (DUF1998)	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
TLS2_k127_2106730_5	215803.DB30_7768	6.963e-28	127.0	COG1670@1|root,COG1670@2|Bacteria,1RD77@1224|Proteobacteria,4351D@68525|delta/epsilon subdivisions,2X948@28221|Deltaproteobacteria,2Z1TW@29|Myxococcales	28221|Deltaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_2106730_4	446470.Snas_3416	1.977e-28	120.0	COG3795@1|root,COG3795@2|Bacteria,2IMHE@201174|Actinobacteria	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_2106730_6	1173025.GEI7407_1822	4.486e-23	104.0	COG3795@1|root,COG3795@2|Bacteria,1G6M3@1117|Cyanobacteria,1HBWD@1150|Oscillatoriales	1117|Cyanobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS2_k127_2106730_2	1463856.JOHY01000001_gene539	1.064e-134	445.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2106730_3	1283299.AUKG01000001_gene2408	3.784e-124	416.0	COG2206@1|root,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,4CR20@84995|Rubrobacteria	84995|Rubrobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
TLS2_k127_2106730_1	1385520.N802_19510	8.541e-137	452.0	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,4FIK3@85021|Intrasporangiaceae	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_2122601_1	929712.KI912613_gene4754	6.871e-41	165.0	COG4942@1|root,COG4942@2|Bacteria,2GP1Y@201174|Actinobacteria,4CPU0@84995|Rubrobacteria	84995|Rubrobacteria	D	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
TLS2_k127_2122601_0	861299.J421_2742	5.636e-154	509.0	COG1138@1|root,COG1138@2|Bacteria,1ZTBY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Cytochrome c-type biogenesis protein CcmF C-terminal	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
TLS2_k127_2122601_3	1122939.ATUD01000007_gene2011	1.312e-17	88.0	COG2332@1|root,COG2332@2|Bacteria,2HP5E@201174|Actinobacteria,4CQHD@84995|Rubrobacteria	84995|Rubrobacteria	O	CcmE	-	-	-	-	-	-	-	-	-	-	-	-	CcmE
TLS2_k127_2122601_4	42256.RradSPS_1817	5.432e-10	72.0	COG1525@1|root,COG1525@2|Bacteria,2GRK1@201174|Actinobacteria,4CQR5@84995|Rubrobacteria	84995|Rubrobacteria	L	Staphylococcal nuclease homologues	-	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	SNase
TLS2_k127_2122601_2	1123023.JIAI01000003_gene3051	4.98e-28	123.0	COG1090@1|root,COG1090@2|Bacteria,2I3Q5@201174|Actinobacteria,4EEAQ@85010|Pseudonocardiales	201174|Actinobacteria	S	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
TLS2_k127_2122601_5	1172181.KB911703_gene412	7.375e-10	65.0	2A543@1|root,30TSR@2|Bacteria,2I8HY@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2165571_1	1283299.AUKG01000001_gene1825	1.156e-82	279.0	COG0438@1|root,COG0438@2|Bacteria,2ICGI@201174|Actinobacteria,4CPFR@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
TLS2_k127_2165571_0	469383.Cwoe_5909	2.931e-134	444.0	COG0380@1|root,COG0380@2|Bacteria,2GMX7@201174|Actinobacteria,4CPJV@84995|Rubrobacteria	84995|Rubrobacteria	G	Glycosyl transferase, family 20	-	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
TLS2_k127_2165571_7	1535287.JP74_16545	1.754e-37	161.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria,3N6ZS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
TLS2_k127_2165571_6	365528.KB891208_gene2825	6.553e-42	168.0	COG0521@1|root,COG0521@2|Bacteria,2II28@201174|Actinobacteria,4ESU1@85013|Frankiales	201174|Actinobacteria	H	TIGRFAM molybdenum cofactor synthesis domain	mog	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoaE
TLS2_k127_2165571_2	1298880.AUEV01000021_gene794	5.727e-75	267.0	COG0382@1|root,COG0382@2|Bacteria,2GJJ7@201174|Actinobacteria	201174|Actinobacteria	H	UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TLS2_k127_2165571_8	768706.Desor_0547	1.256e-33	148.0	COG1131@1|root,COG1131@2|Bacteria,1V7J1@1239|Firmicutes,24PJ1@186801|Clostridia,263T7@186807|Peptococcaceae	186801|Clostridia	V	heme ABC exporter, ATP-binding protein CcmA	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
TLS2_k127_2165571_9	717231.Flexsi_2160	1.988e-22	110.0	COG2386@1|root,COG2386@2|Bacteria,2GF4W@200930|Deferribacteres	200930|Deferribacteres	O	CcmB protein	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
TLS2_k127_2165571_5	1380390.JIAT01000009_gene1905	1.159e-48	183.0	COG0755@1|root,COG0755@2|Bacteria,2IIHK@201174|Actinobacteria,4CSM2@84995|Rubrobacteria	84995|Rubrobacteria	O	Cytochrome C assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
TLS2_k127_2165571_3	1267535.KB906767_gene5048	1.258e-58	215.0	COG0181@1|root,COG0181@2|Bacteria,3Y3RY@57723|Acidobacteria,2JIR3@204432|Acidobacteriia	204432|Acidobacteriia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
TLS2_k127_2165571_10	1283299.AUKG01000001_gene1869	1.613e-12	80.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2GK3B@201174|Actinobacteria,4CPJJ@84995|Rubrobacteria	84995|Rubrobacteria	H	Uroporphyrinogen-III synthase HemD	-	-	2.1.1.107,4.2.1.75	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
TLS2_k127_2165571_4	1068980.ARVW01000001_gene3483	9.031e-51	184.0	COG1912@1|root,COG1912@2|Bacteria,2IASJ@201174|Actinobacteria,4E3VM@85010|Pseudonocardiales	201174|Actinobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
TLS2_k127_2217566_2	526227.Mesil_2250	3.58e-43	173.0	COG0477@1|root,COG0477@2|Bacteria,1WNH1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_2217566_1	1283299.AUKG01000001_gene3167	9.758e-75	267.0	COG0477@1|root,COG2814@2|Bacteria,2I9WU@201174|Actinobacteria,4CS2U@84995|Rubrobacteria	84995|Rubrobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_2217566_3	1120950.KB892768_gene5341	1.058e-21	109.0	COG1254@1|root,COG1254@2|Bacteria,2HZEW@201174|Actinobacteria,4DSGP@85009|Propionibacteriales	201174|Actinobacteria	C	Acylphosphatase	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
TLS2_k127_2217566_4	66429.JOFL01000025_gene5430	3.081e-12	77.0	COG3874@1|root,COG3874@2|Bacteria,2IRFM@201174|Actinobacteria	201174|Actinobacteria	S	Sporulation protein YtfJ	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
TLS2_k127_2217566_0	266117.Rxyl_0816	1.519e-111	363.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2GM09@201174|Actinobacteria,4CPPY@84995|Rubrobacteria	84995|Rubrobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
TLS2_k127_2229120_5	357808.RoseRS_4430	5.006e-33	130.0	COG0381@1|root,COG0381@2|Bacteria,2G7S6@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.14,5.1.3.23	ko:K01791,ko:K13019	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420,R09600	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
TLS2_k127_2229120_0	502025.Hoch_0307	1.799e-83	292.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,42NV0@68525|delta/epsilon subdivisions,2X9QV@28221|Deltaproteobacteria,2Z1C8@29|Myxococcales	28221|Deltaproteobacteria	S	Homoserine dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_2229120_1	1128421.JAGA01000002_gene737	4.564e-63	239.0	COG1044@1|root,COG1044@2|Bacteria,2NPGJ@2323|unclassified Bacteria	2|Bacteria	M	Hexapeptide repeat of succinyl-transferase	wbbJ	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2
TLS2_k127_2229120_4	324602.Caur_3397	2.487e-43	177.0	COG1404@1|root,COG1404@2|Bacteria,2G7HM@200795|Chloroflexi,375CA@32061|Chloroflexia	32061|Chloroflexia	M	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS2_k127_2229120_3	1283299.AUKG01000001_gene1932	3.748e-56	217.0	COG2385@1|root,COG2385@2|Bacteria,2ID9T@201174|Actinobacteria,4CPMQ@84995|Rubrobacteria	84995|Rubrobacteria	D	Stage II sporulation protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
TLS2_k127_2229120_2	1121017.AUFG01000007_gene1243	5.455e-59	224.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4FFET@85021|Intrasporangiaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_2229120_6	1121378.KB899700_gene1938	0.0008002	42.0	COG1088@1|root,COG1088@2|Bacteria,1WJHN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_223494_8	649747.HMPREF0083_04448	1.506e-55	197.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,4HA4I@91061|Bacilli,26TIA@186822|Paenibacillaceae	91061|Bacilli	Q	4-hydroxyphenylacetate 3-hydroxylase N terminal	yoaI	-	1.14.14.9	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	-	R02698,R03299	RC00046	ko00000,ko00001,ko01000	-	-	-	HpaB,HpaB_N
TLS2_k127_223494_12	330084.JNYZ01000020_gene4642	4.201e-38	150.0	COG1853@1|root,COG1853@2|Bacteria,2INYP@201174|Actinobacteria,4EEX2@85010|Pseudonocardiales	201174|Actinobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TLS2_k127_223494_3	266117.Rxyl_1033	7.037e-85	290.0	COG2514@1|root,COG2514@2|Bacteria,2I5Q1@201174|Actinobacteria,4CQIX@84995|Rubrobacteria	84995|Rubrobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_223494_6	1380390.JIAT01000009_gene1464	2.625e-67	247.0	COG2367@1|root,COG2367@2|Bacteria,2HMJZ@201174|Actinobacteria,4CQCV@84995|Rubrobacteria	84995|Rubrobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase2
TLS2_k127_223494_5	395019.Bmul_3822	8.475e-68	250.0	COG0531@1|root,COG0531@2|Bacteria,1R4PP@1224|Proteobacteria,2VMV2@28216|Betaproteobacteria,1KCZ8@119060|Burkholderiaceae	28216|Betaproteobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
TLS2_k127_223494_2	1121396.KB893082_gene933	3.293e-104	354.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2MJ5M@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Glutamine synthetase, catalytic domain	glnA1	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N,Gln-synt_N_2
TLS2_k127_223494_16	105425.BBPL01000027_gene580	6.095e-18	98.0	COG2346@1|root,COG3369@1|root,COG3592@1|root,COG2346@2|Bacteria,COG3369@2|Bacteria,COG3592@2|Bacteria,2GMG5@201174|Actinobacteria,2NI62@228398|Streptacidiphilus	201174|Actinobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin,Fer4_19,zf-CDGSH
TLS2_k127_223494_10	1273125.Rrhod_1662	2.224e-51	196.0	COG0346@1|root,COG0346@2|Bacteria,2IMDZ@201174|Actinobacteria,4G1YU@85025|Nocardiaceae	201174|Actinobacteria	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_223494_11	1032480.MLP_26560	1.715e-44	169.0	COG4330@1|root,COG4330@2|Bacteria,2IBF3@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1361)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1361
TLS2_k127_223494_9	266117.Rxyl_2370	2.338e-54	212.0	COG0179@1|root,COG0179@2|Bacteria,2GKED@201174|Actinobacteria,4CQ58@84995|Rubrobacteria	84995|Rubrobacteria	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
TLS2_k127_223494_14	1235457.C404_16265	3.423e-20	99.0	COG0599@1|root,COG0599@2|Bacteria,1RH7V@1224|Proteobacteria,2VR3W@28216|Betaproteobacteria,1K7M2@119060|Burkholderiaceae	28216|Betaproteobacteria	S	carboxymuconolactone decarboxylase	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
TLS2_k127_223494_0	67373.JOBF01000001_gene6223	2.188e-141	463.0	COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS2_k127_223494_15	1206741.BAFX01000133_gene1904	1.655e-18	91.0	COG2050@1|root,COG2050@2|Bacteria,2GKY1@201174|Actinobacteria,4G07Y@85025|Nocardiaceae	201174|Actinobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS2_k127_223494_4	706587.Desti_0471	1.181e-84	287.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,42MTN@68525|delta/epsilon subdivisions,2WJAI@28221|Deltaproteobacteria,2MQUJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rmlA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS2_k127_223494_13	565033.GACE_1123	7.493e-22	109.0	COG1898@1|root,arCOG04188@2157|Archaea,2XWJQ@28890|Euryarchaeota,245RU@183980|Archaeoglobi	183980|Archaeoglobi	M	dTDP-4-dehydrorhamnose 3,5-epimerase	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
TLS2_k127_223494_7	469383.Cwoe_5788	3.255e-62	225.0	COG1091@1|root,COG1091@2|Bacteria,2GNY8@201174|Actinobacteria,4CPVG@84995|Rubrobacteria	84995|Rubrobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
TLS2_k127_223494_1	479434.Sthe_0968	4.557e-128	417.0	COG1088@1|root,COG1088@2|Bacteria,2G5KR@200795|Chloroflexi,27XGB@189775|Thermomicrobia	189775|Thermomicrobia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_2242691_2	929703.KE386491_gene1966	5.165e-15	89.0	COG3211@1|root,COG3211@2|Bacteria,4NFM3@976|Bacteroidetes,47MKF@768503|Cytophagia	976|Bacteroidetes	S	Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2242691_3	67267.JNXT01000009_gene733	5.426e-13	70.0	COG0262@1|root,COG0262@2|Bacteria,2GMZV@201174|Actinobacteria	201174|Actinobacteria	H	PFAM bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_2242691_4	1502851.FG93_01170	4.045e-08	55.0	COG0262@1|root,COG0262@2|Bacteria,1MU1W@1224|Proteobacteria,2U0RG@28211|Alphaproteobacteria,3JUIU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_2242691_0	1120950.KB892753_gene6092	2.286e-48	192.0	COG1721@1|root,COG1721@2|Bacteria,2I9E2@201174|Actinobacteria,4DQW5@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_2242691_1	543632.JOJL01000008_gene5878	1.802e-25	108.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4DAWH@85008|Micromonosporales	201174|Actinobacteria	S	ATPase associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_2261856_5	479434.Sthe_0203	8.303e-19	93.0	COG4454@1|root,COG4454@2|Bacteria,2GA6H@200795|Chloroflexi,27YMB@189775|Thermomicrobia	189775|Thermomicrobia	P	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
TLS2_k127_2261856_4	671065.MetMK1DRAFT_00029870	9.724e-29	121.0	COG0432@1|root,arCOG04214@2157|Archaea,2XQYP@28889|Crenarchaeota	28889|Crenarchaeota	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TLS2_k127_2261856_1	1101188.KI912155_gene610	3.438e-118	423.0	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria,1W8G0@1268|Micrococcaceae	201174|Actinobacteria	L	UvrD-like helicase C-terminal domain	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
TLS2_k127_2261856_0	2002.JOEQ01000037_gene4324	1.823e-196	627.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,4EFZC@85012|Streptosporangiales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	fdh	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
TLS2_k127_2261856_3	1133850.SHJG_5070	7.101e-56	201.0	COG5637@1|root,COG5637@2|Bacteria,2GP5P@201174|Actinobacteria	201174|Actinobacteria	S	cyclase dehydrase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TLS2_k127_2261856_2	1122939.ATUD01000012_gene3177	3.733e-86	298.0	COG0346@1|root,COG0346@2|Bacteria,2II51@201174|Actinobacteria,4CSB8@84995|Rubrobacteria	84995|Rubrobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_2281190_0	446466.Cfla_2352	4.628e-65	232.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	wbbL_1	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
TLS2_k127_232732_3	1380390.JIAT01000010_gene4181	4.223e-86	294.0	COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria,4CPBT@84995|Rubrobacteria	84995|Rubrobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
TLS2_k127_232732_4	765910.MARPU_16585	2.587e-68	255.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1WXMZ@135613|Chromatiales	135613|Chromatiales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
TLS2_k127_232732_0	469383.Cwoe_3729	1.853e-177	565.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,4CPIK@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
TLS2_k127_232732_6	33876.JNXY01000005_gene8577	2.231e-47	179.0	2AZDP@1|root,31RMA@2|Bacteria,2GUFH@201174|Actinobacteria,4DCA2@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF4230)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4230
TLS2_k127_232732_9	1382304.JNIL01000001_gene1024	1.186e-30	141.0	COG1321@1|root,COG1321@2|Bacteria,1V4V7@1239|Firmicutes,4HI7T@91061|Bacilli	91061|Bacilli	K	Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon	mntR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
TLS2_k127_232732_2	469383.Cwoe_3727	1.27e-144	495.0	COG1198@1|root,COG1198@2|Bacteria,2GKES@201174|Actinobacteria,4CPGM@84995|Rubrobacteria	84995|Rubrobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	-	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
TLS2_k127_232732_7	446462.Amir_3391	2.481e-42	177.0	COG1670@1|root,COG1670@2|Bacteria,2HJTN@201174|Actinobacteria,4E73N@85010|Pseudonocardiales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_232732_1	1246995.AFR_06190	9.644e-171	540.0	COG2515@1|root,COG2515@2|Bacteria,2GIV5@201174|Actinobacteria,4DD98@85008|Micromonosporales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	acdS	-	3.5.99.7,4.4.1.15	ko:K01505,ko:K05396	ko00270,map00270	-	R00997,R01874	RC00382,RC00419	ko00000,ko00001,ko01000	-	-	-	PALP
TLS2_k127_232732_8	1380390.JIAT01000010_gene4188	6.724e-41	157.0	COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,4CQ1V@84995|Rubrobacteria	84995|Rubrobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TLS2_k127_232732_5	1122939.ATUD01000004_gene3768	9.761e-61	219.0	COG0223@1|root,COG0223@2|Bacteria,2GKH5@201174|Actinobacteria,4CQ89@84995|Rubrobacteria	84995|Rubrobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TLS2_k127_2347873_1	1122609.AUGT01000012_gene4236	2.351e-05	57.0	COG3391@1|root,COG4254@1|root,COG3391@2|Bacteria,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2347873_0	1140.Synpcc7942_0529	2.8e-41	164.0	COG0363@1|root,COG0363@2|Bacteria,1G20H@1117|Cyanobacteria,1GZ3E@1129|Synechococcus	1117|Cyanobacteria	G	6-phosphogluconolactonase	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
TLS2_k127_2359603_3	28444.JODQ01000008_gene1045	1.282e-40	159.0	COG3544@1|root,COG3544@2|Bacteria,2IKUE@201174|Actinobacteria,4EJD4@85012|Streptosporangiales	201174|Actinobacteria	S	Domain of unknown function (DUF4142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
TLS2_k127_2359603_0	263358.VAB18032_27406	1.697e-221	702.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4D971@85008|Micromonosporales	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_2359603_1	469383.Cwoe_0326	2.409e-163	524.0	COG4292@1|root,COG4292@2|Bacteria,2GJPB@201174|Actinobacteria	201174|Actinobacteria	S	Low temperature requirement	-	-	-	-	-	-	-	-	-	-	-	-	LtrA
TLS2_k127_2359603_6	1476876.JOJO01000005_gene5253	1.763e-09	64.0	2AVRK@1|root,31MIX@2|Bacteria,2IN9C@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2359603_5	1283299.AUKG01000003_gene257	4.776e-26	119.0	COG0392@1|root,COG0392@2|Bacteria,2HNI1@201174|Actinobacteria,4CPH1@84995|Rubrobacteria	84995|Rubrobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
TLS2_k127_2359603_4	196162.Noca_2546	1.484e-31	132.0	COG0584@1|root,COG0584@2|Bacteria,2GVYH@201174|Actinobacteria	201174|Actinobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2359603_2	1048339.KB913029_gene4254	5.912e-54	202.0	COG0671@1|root,COG0671@2|Bacteria,2GMYU@201174|Actinobacteria	201174|Actinobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
TLS2_k127_2401126_1	1122939.ATUD01000012_gene3141	1.251e-28	117.0	COG2127@1|root,COG2127@2|Bacteria,2HPG0@201174|Actinobacteria,4CQUJ@84995|Rubrobacteria	84995|Rubrobacteria	S	ATP-dependent Clp protease adaptor protein ClpS	-	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
TLS2_k127_2401126_0	1089544.KB912942_gene3290	1.504e-39	167.0	COG0577@1|root,COG0577@2|Bacteria,2IE56@201174|Actinobacteria,4DYHP@85010|Pseudonocardiales	201174|Actinobacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS2_k127_2412055_1	251221.35211790	1.02e-124	429.0	COG0146@1|root,COG0146@2|Bacteria,1GCWJ@1117|Cyanobacteria	1117|Cyanobacteria	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
TLS2_k127_2412055_0	469383.Cwoe_1857	1.484e-154	509.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4CPCB@84995|Rubrobacteria	84995|Rubrobacteria	EQ	Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
TLS2_k127_2412055_2	937777.Deipe_0733	5.568e-09	66.0	292EJ@1|root,2ZPYT@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06197	-	-	-	-	ko00000	-	-	-	ChaB
TLS2_k127_2428262_6	351607.Acel_0084	1.29e-38	149.0	COG3642@1|root,COG3642@2|Bacteria,2GIX0@201174|Actinobacteria,4ERCM@85013|Frankiales	201174|Actinobacteria	T	Domain of unknown function (DUF4032)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032,Kdo
TLS2_k127_2428262_3	469615.FGAG_00533	1.785e-84	296.0	COG1171@1|root,COG1171@2|Bacteria,378K1@32066|Fusobacteria	32066|Fusobacteria	E	Threonine dehydratase	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
TLS2_k127_2428262_8	1298858.AUEL01000026_gene3435	1.664e-34	139.0	2EK0M@1|root,33DR5@2|Bacteria,1NKNS@1224|Proteobacteria,2UNJZ@28211|Alphaproteobacteria,43P8N@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Predicted integral membrane protein (DUF2269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2269
TLS2_k127_2428262_2	981369.JQMJ01000004_gene3779	5.522e-86	293.0	COG0596@1|root,COG0596@2|Bacteria,2H406@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_2428262_9	29306.JOBE01000030_gene936	1.31e-33	133.0	COG3070@1|root,COG3070@2|Bacteria,2IKKV@201174|Actinobacteria	201174|Actinobacteria	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
TLS2_k127_2428262_5	1380390.JIAT01000010_gene3926	1.354e-44	170.0	2AWR3@1|root,31NN1@2|Bacteria,2HR71@201174|Actinobacteria,4CT2W@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2428262_1	1211815.CBYP010000050_gene639	4.327e-89	317.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4ETYC@85013|Frankiales	201174|Actinobacteria	T	Two component transcriptional regulator, winged helix family	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_2428262_0	365528.KB891228_gene282	7.785e-125	417.0	COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,2GIV9@201174|Actinobacteria,4EUCV@85013|Frankiales	201174|Actinobacteria	T	integral membrane sensor signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_2428262_4	196162.Noca_2005	1.81e-78	273.0	COG0515@1|root,COG0515@2|Bacteria,2IAFS@201174|Actinobacteria,4DQXW@85009|Propionibacteriales	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS2_k127_2428262_10	1283299.AUKG01000002_gene4682	1.613e-31	135.0	COG2391@1|root,COG2391@2|Bacteria,2HR1F@201174|Actinobacteria,4CSVN@84995|Rubrobacteria	84995|Rubrobacteria	S	Sulphur transport	-	-	-	-	-	-	-	-	-	-	-	-	Sulf_transp
TLS2_k127_2428262_7	1283299.AUKG01000002_gene4683	5.563e-37	147.0	COG2391@1|root,COG2391@2|Bacteria,2I94E@201174|Actinobacteria,4CQVD@84995|Rubrobacteria	84995|Rubrobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
TLS2_k127_2439666_11	1499686.BN1079_02244	4.64e-14	85.0	COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,1RZ5C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_2439666_9	1075090.GOAMR_03_00100	4.893e-27	121.0	COG1216@1|root,COG1216@2|Bacteria,2GKTW@201174|Actinobacteria,4GBS0@85026|Gordoniaceae	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_transf_7C,Glycos_transf_2
TLS2_k127_2439666_5	395961.Cyan7425_1728	2.147e-55	204.0	COG1216@1|root,COG1216@2|Bacteria,1GQEZ@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_2,Glycos_transf_2
TLS2_k127_2439666_10	1232410.KI421421_gene3605	7.097e-26	126.0	COG2244@1|root,COG2244@2|Bacteria,1NB5K@1224|Proteobacteria,43AXB@68525|delta/epsilon subdivisions,2X6BJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
TLS2_k127_2439666_13	235985.BBPN01000009_gene3723	4.895e-09	70.0	2E2EJ@1|root,32XJ3@2|Bacteria,2ISI6@201174|Actinobacteria,2NKMK@228398|Streptacidiphilus	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_2439666_2	1386969.AWTB01000007_gene2728	1.424e-69	255.0	COG0438@1|root,COG0438@2|Bacteria,2IEM5@201174|Actinobacteria,4GCQB@85026|Gordoniaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_2439666_8	1380390.JIAT01000013_gene230	1.02e-28	128.0	COG0662@1|root,COG0662@2|Bacteria,2HR0E@201174|Actinobacteria,4CSU6@84995|Rubrobacteria	84995|Rubrobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2439666_12	68194.JNXR01000020_gene538	3.361e-13	81.0	COG1917@1|root,COG1917@2|Bacteria,2I43Q@201174|Actinobacteria	201174|Actinobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2439666_7	591158.SSMG_01277	2.624e-51	184.0	COG0640@1|root,COG0640@2|Bacteria,2IHS2@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS2_k127_2439666_6	1121377.KB906405_gene108	6.082e-54	193.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_2439666_3	1463881.KL591009_gene165	4.456e-66	237.0	COG0697@1|root,COG0697@2|Bacteria,2I91Y@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_2439666_4	405948.SACE_3168	8.046e-60	212.0	COG3865@1|root,COG3865@2|Bacteria,2IIAX@201174|Actinobacteria,4E5A2@85010|Pseudonocardiales	201174|Actinobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
TLS2_k127_2439666_1	298655.KI912266_gene6468	7.781e-76	277.0	COG0477@1|root,COG0477@2|Bacteria,2IDYF@201174|Actinobacteria	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_2439666_0	1185876.BN8_02171	2.785e-83	289.0	28PTG@1|root,2ZCEQ@2|Bacteria,4NWVQ@976|Bacteroidetes,47W24@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2520419_2	929712.KI912613_gene4629	1.084e-64	237.0	COG0263@1|root,COG0263@2|Bacteria,2GM8U@201174|Actinobacteria,4CR1D@84995|Rubrobacteria	84995|Rubrobacteria	E	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	-	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
TLS2_k127_2520419_0	928724.SacglDRAFT_03246	2.102e-114	382.0	COG0014@1|root,COG0014@2|Bacteria,2GISA@201174|Actinobacteria,4DZ1E@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_2520419_3	82654.Pse7367_1525	1.587e-25	115.0	arCOG08935@1|root,32Z08@2|Bacteria,1GAUH@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2520419_1	926569.ANT_29930	3.151e-90	311.0	COG2116@1|root,COG2116@2|Bacteria,2G967@200795|Chloroflexi	200795|Chloroflexi	P	Formate/nitrite transporter	-	-	-	ko:K06212	-	-	-	-	ko00000,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	Form_Nir_trans
TLS2_k127_2520419_4	1223542.GM1_005_00140	6.109e-11	64.0	COG0433@1|root,COG0433@2|Bacteria,2GKVW@201174|Actinobacteria,4GBR7@85026|Gordoniaceae	201174|Actinobacteria	S	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	AAA,DUF87,Zot
TLS2_k127_2541072_4	292459.STH819	2.605e-38	154.0	COG1427@1|root,COG1427@2|Bacteria,1V2PX@1239|Firmicutes,24CGN@186801|Clostridia	186801|Clostridia	H	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
TLS2_k127_2541072_5	525904.Tter_2789	2.052e-36	143.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	ble	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_2541072_0	1121468.AUBR01000016_gene2306	8.06e-111	379.0	COG1060@1|root,COG1060@2|Bacteria,1TQNG@1239|Firmicutes,24AHE@186801|Clostridia,42FB5@68295|Thermoanaerobacterales	186801|Clostridia	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
TLS2_k127_2541072_2	469383.Cwoe_5924	1.104e-62	228.0	COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4CQGP@84995|Rubrobacteria	84995|Rubrobacteria	H	Belongs to the FPP GGPP synthase family	-	-	-	-	-	-	-	-	-	-	-	-	polyprenyl_synt
TLS2_k127_2541072_1	1380390.JIAT01000009_gene1822	5.863e-69	250.0	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4CSAX@84995|Rubrobacteria	84995|Rubrobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS2_k127_2541072_3	1177154.Y5S_00783	6.311e-54	196.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1XHWE@135619|Oceanospirillales	135619|Oceanospirillales	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
TLS2_k127_25713_1	1137268.AZXF01000014_gene148	4.051e-90	302.0	COG1051@1|root,COG1051@2|Bacteria,2GNMT@201174|Actinobacteria,4EI24@85012|Streptosporangiales	201174|Actinobacteria	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS2_k127_25713_2	243265.plu0841	8.557e-62	217.0	COG1335@1|root,COG1335@2|Bacteria,1MZP9@1224|Proteobacteria,1SHQ7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS2_k127_25713_0	266117.Rxyl_2540	4.685e-183	584.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4CPJ8@84995|Rubrobacteria	84995|Rubrobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
TLS2_k127_2577882_1	272134.KB731324_gene3741	1.104e-133	432.0	COG0667@1|root,COG0667@2|Bacteria,1G3WV@1117|Cyanobacteria,1HH84@1150|Oscillatoriales	1117|Cyanobacteria	C	Aldo/keto reductase family	-	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
TLS2_k127_2577882_4	1122609.AUGT01000020_gene1103	4.432e-37	156.0	COG0457@1|root,COG1396@1|root,COG0457@2|Bacteria,COG1396@2|Bacteria,2GNQ9@201174|Actinobacteria,4DWX6@85009|Propionibacteriales	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31,TPR_12,TPR_16
TLS2_k127_2577882_0	1380390.JIAT01000009_gene1894	2.181e-184	606.0	COG1061@1|root,COG1061@2|Bacteria,2GIR9@201174|Actinobacteria,4CPIG@84995|Rubrobacteria	84995|Rubrobacteria	L	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	ERCC3_RAD25_C,Helicase_C,ResIII
TLS2_k127_2577882_2	1283299.AUKG01000001_gene1973	7.085e-86	293.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4CP8R@84995|Rubrobacteria	84995|Rubrobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
TLS2_k127_2577882_3	106370.Francci3_1653	2.115e-39	162.0	COG1612@1|root,COG1612@2|Bacteria,2GJQX@201174|Actinobacteria,4ESN0@85013|Frankiales	201174|Actinobacteria	O	cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
TLS2_k127_2577882_5	264732.Moth_1625	2.551e-24	106.0	COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,42ENJ@68295|Thermoanaerobacterales	186801|Clostridia	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
TLS2_k127_2642364_1	1283299.AUKG01000001_gene1897	3.81e-146	474.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4CRWP@84995|Rubrobacteria	84995|Rubrobacteria	O	Peptidase family M41	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Peptidase_M41
TLS2_k127_2642364_0	469383.Cwoe_5866	1.51e-155	497.0	COG1488@1|root,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria,4CQTG@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	Isochorismatase,QRPTase_C,QRPTase_N
TLS2_k127_2642364_2	1283299.AUKG01000001_gene1889	2.158e-52	195.0	COG3872@1|root,COG3872@2|Bacteria,2HQG9@201174|Actinobacteria,4CS1C@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function (DUF1385)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
TLS2_k127_2642364_3	469383.Cwoe_5867	3.043e-37	148.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4CRVV@84995|Rubrobacteria	84995|Rubrobacteria	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_264778_1	1463825.JNXC01000001_gene5541	4.21e-85	301.0	COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,4DX43@85010|Pseudonocardiales	201174|Actinobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS2_k127_264778_2	1122939.ATUD01000006_gene1585	7.729e-64	227.0	COG1028@1|root,COG1028@2|Bacteria,2IA5V@201174|Actinobacteria,4CT11@84995|Rubrobacteria	84995|Rubrobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_264778_0	926560.KE387023_gene2373	1.968e-178	584.0	COG0001@1|root,COG0001@2|Bacteria,1WM90@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_264778_3	306281.AJLK01000102_gene3405	8.413e-49	196.0	COG2258@1|root,COG2258@2|Bacteria,1GE7I@1117|Cyanobacteria	1117|Cyanobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_264778_4	1193181.BN10_1080025	1.393e-13	74.0	COG2321@1|root,COG2321@2|Bacteria,2H3UT@201174|Actinobacteria,4FFIT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative neutral zinc metallopeptidase	ypfJ	GO:0005575,GO:0005576	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
TLS2_k127_266663_2	469383.Cwoe_5243	1.081e-36	150.0	COG1825@1|root,COG1825@2|Bacteria,2GJPJ@201174|Actinobacteria,4CQ60@84995|Rubrobacteria	84995|Rubrobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
TLS2_k127_266663_1	1415166.NONO_c66400	7.476e-54	195.0	COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria,4FWYC@85025|Nocardiaceae	201174|Actinobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
TLS2_k127_266663_0	469383.Cwoe_5241	1.43e-306	979.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4CP78@84995|Rubrobacteria	84995|Rubrobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS2_k127_266663_3	266117.Rxyl_0911	1.561e-36	153.0	COG0760@1|root,COG0760@2|Bacteria,2IGXV@201174|Actinobacteria,4CU3I@84995|Rubrobacteria	84995|Rubrobacteria	M	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	SurA_N_3
TLS2_k127_2751221_0	929712.KI912613_gene21	2.842e-116	389.0	COG0025@1|root,COG0025@2|Bacteria,2GKCK@201174|Actinobacteria,4CQMT@84995|Rubrobacteria	84995|Rubrobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS2_k127_2751221_1	1123023.JIAI01000002_gene5557	2.687e-100	336.0	COG0030@1|root,COG0030@2|Bacteria,2GIZ8@201174|Actinobacteria,4DYTH@85010|Pseudonocardiales	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_2751221_2	1713.JOFV01000001_gene1839	1.871e-09	59.0	COG1983@1|root,COG1983@2|Bacteria,2GQG0@201174|Actinobacteria	201174|Actinobacteria	KT	PspC domain protein	pspC1	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
TLS2_k127_2805847_2	1267535.KB906767_gene392	1.233e-09	61.0	COG3643@1|root,COG3643@2|Bacteria,3Y3HP@57723|Acidobacteria,2JIP9@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Formiminotransferase domain	-	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_N
TLS2_k127_2805847_1	324602.Caur_1093	8.327e-18	85.0	COG0823@1|root,COG1520@1|root,COG0823@2|Bacteria,COG1520@2|Bacteria,2GB15@200795|Chloroflexi,377Q0@32061|Chloroflexia	32061|Chloroflexia	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2805847_0	1183438.GKIL_2511	1.833e-158	522.0	COG2986@1|root,COG2986@2|Bacteria,1G3FJ@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Phenylalanine and histidine ammonia-lyase	hutH	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009072,GO:0009698,GO:0009699,GO:0009800,GO:0009803,GO:0009987,GO:0016043,GO:0016053,GO:0016829,GO:0016840,GO:0016841,GO:0019438,GO:0019748,GO:0019752,GO:0022607,GO:0032787,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044550,GO:0045548,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	4.3.1.24,4.3.1.3	ko:K01745,ko:K10775	ko00340,ko00360,ko00940,ko01100,ko01110,map00340,map00360,map00940,map01100,map01110	M00039,M00045,M00137,M00350	R00697,R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
TLS2_k127_2810787_1	365046.Rta_27230	2.538e-91	318.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2VJ3D@28216|Betaproteobacteria,4ACA8@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
TLS2_k127_2810787_0	1306406.ASHX01000001_gene4316	3.666e-130	436.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,2GJB4@201174|Actinobacteria	201174|Actinobacteria	CE	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
TLS2_k127_2810787_2	1380390.JIAT01000012_gene2898	1.503e-31	126.0	COG1595@1|root,COG1595@2|Bacteria,2IG3F@201174|Actinobacteria,4CT96@84995|Rubrobacteria	84995|Rubrobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2814870_1	1122622.ATWJ01000002_gene800	5.411e-49	182.0	COG2114@1|root,COG2197@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_2814870_2	1348663.KCH_28740	1.249e-17	91.0	COG0346@1|root,COG0346@2|Bacteria,2HP3N@201174|Actinobacteria,2M5WZ@2063|Kitasatospora	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_2814870_0	1380391.JIAS01000012_gene4124	1.971e-65	237.0	COG2114@1|root,COG2114@2|Bacteria,1ND4Q@1224|Proteobacteria,2U51W@28211|Alphaproteobacteria,2JXWG@204441|Rhodospirillales	204441|Rhodospirillales	T	Protein of unknown function (DUF2652)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2652
TLS2_k127_2814870_3	469383.Cwoe_2649	6.02e-09	57.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,4CPB5@84995|Rubrobacteria	84995|Rubrobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
TLS2_k127_2841909_6	351607.Acel_1449	6.041e-33	131.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4ERG0@85013|Frankiales	201174|Actinobacteria	T	Two component transcriptional regulator, winged helix family	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_2841909_7	929712.KI912613_gene3681	8.607e-17	93.0	COG2149@1|root,COG2149@2|Bacteria,2HTN4@201174|Actinobacteria,4CSZK@84995|Rubrobacteria	84995|Rubrobacteria	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
TLS2_k127_2841909_1	1380391.JIAS01000013_gene3815	1.805e-83	288.0	COG5285@1|root,COG5285@2|Bacteria,1RABR@1224|Proteobacteria,2UN8G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS2_k127_2841909_0	1089545.KB913037_gene8292	5.765e-182	603.0	COG2197@1|root,COG2197@2|Bacteria,2I321@201174|Actinobacteria,4EF7G@85010|Pseudonocardiales	201174|Actinobacteria	KT	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS2_k127_2841909_4	1051646.VITU9109_14061	1.829e-61	225.0	COG0265@1|root,COG3291@1|root,COG0265@2|Bacteria,COG3291@2|Bacteria,1R6VW@1224|Proteobacteria,1SNEA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2841909_8	644281.MFS40622_0774	2.674e-09	60.0	arCOG13418@1|root,arCOG13418@2157|Archaea,2Y5VK@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2841909_2	351160.RCIX1128	9.177e-77	269.0	COG1063@1|root,arCOG01459@2157|Archaea,2XT9P@28890|Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway	gdh	GO:0000166,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005515,GO:0005534,GO:0005536,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006012,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019318,GO:0019320,GO:0019388,GO:0019595,GO:0022607,GO:0030246,GO:0033498,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046430,GO:0046872,GO:0046914,GO:0046983,GO:0047910,GO:0047936,GO:0048029,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051262,GO:0051287,GO:0055114,GO:0065003,GO:0070401,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.1.1.140,1.1.1.359,1.1.1.360	ko:K00068,ko:K18124,ko:K18125	ko00030,ko00051,ko00052,ko01100,ko01110,ko01130,ko01200,map00030,map00051,map00052,map01100,map01110,map01130,map01200	-	R01096,R05607,R07147,R08544	RC00066,RC00085	ko00000,ko00001,ko01000	-	-	-	ADH_N,Glu_dehyd_C
TLS2_k127_2841909_3	309801.trd_0248	7.259e-64	226.0	COG1028@1|root,COG1028@2|Bacteria,2G6IK@200795|Chloroflexi,27Y50@189775|Thermomicrobia	189775|Thermomicrobia	IQ	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_2841909_5	1463853.JOHW01000031_gene2922	4.407e-50	183.0	COG3386@1|root,COG3386@2|Bacteria,2GNV1@201174|Actinobacteria	201174|Actinobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
TLS2_k127_2842035_2	405948.SACE_4612	1.465e-15	78.0	COG4274@1|root,COG4274@2|Bacteria,2IJ0R@201174|Actinobacteria,4ECGK@85010|Pseudonocardiales	201174|Actinobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
TLS2_k127_2842035_1	326427.Cagg_2729	1.151e-39	171.0	COG0577@1|root,COG0577@2|Bacteria,2G68F@200795|Chloroflexi,376ZY@32061|Chloroflexia	32061|Chloroflexia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_2842035_0	324602.Caur_0822	7.872e-73	250.0	COG1136@1|root,COG1136@2|Bacteria,2G6C9@200795|Chloroflexi,37685@32061|Chloroflexia	32061|Chloroflexia	V	ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,cNMP_binding
TLS2_k127_2852643_1	1487953.JMKF01000021_gene2224	3.765e-143	472.0	COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria	2|Bacteria	K	phosphorelay signal transduction system	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,TPR_8,Trans_reg_C
TLS2_k127_2852643_3	105420.BBPO01000020_gene5622	5.474e-09	66.0	2EFF7@1|root,33981@2|Bacteria,2IFB2@201174|Actinobacteria,2NIKK@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2852643_2	1121924.ATWH01000010_gene1007	2.656e-58	208.0	COG1309@1|root,COG1309@2|Bacteria,2I8Z7@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_2852643_0	1380390.JIAT01000013_gene123	8.15e-305	956.0	COG2267@1|root,COG4671@1|root,COG2267@2|Bacteria,COG4671@2|Bacteria	2|Bacteria	I	Glycosyl Transferase	yvaM	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Glyco_tran_28_C,Hydrolase_4
TLS2_k127_2863141_1	706587.Desti_0251	8.078e-46	181.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WKB1@28221|Deltaproteobacteria,2MR2G@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_2863141_0	552811.Dehly_0593	1.031e-54	218.0	COG3437@1|root,COG3437@2|Bacteria,2G6QF@200795|Chloroflexi,34CZJ@301297|Dehalococcoidia	301297|Dehalococcoidia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,Response_reg
TLS2_k127_2863141_3	441620.Mpop_3747	1.932e-29	136.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2U0JP@28211|Alphaproteobacteria,1JSWC@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_2863141_2	402777.KB235904_gene3158	3.751e-30	137.0	COG0642@1|root,COG2199@1|root,COG3437@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,COG3706@2|Bacteria,1G09B@1117|Cyanobacteria,1H71H@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_2871552_8	429009.Adeg_1277	9.668e-06	53.0	COG3404@1|root,COG3404@2|Bacteria,1V1X8@1239|Firmicutes,24JZM@186801|Clostridia,42G3N@68295|Thermoanaerobacterales	186801|Clostridia	E	cyclohydrolase	fchA	-	4.3.1.4	ko:K01746	ko00670,ko01100,map00670,map01100	-	R02302	RC00688	ko00000,ko00001,ko01000	-	-	-	FTCD_C
TLS2_k127_2871552_1	1313172.YM304_29160	4.536e-109	379.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4CP57@84992|Acidimicrobiia	201174|Actinobacteria	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	3.6.3.21	ko:K02028,ko:K09972,ko:K10041	ko02010,map02010	M00228,M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
TLS2_k127_2871552_7	383372.Rcas_1456	8.99e-81	299.0	COG0765@1|root,COG0765@2|Bacteria,2G845@200795|Chloroflexi,376Y4@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
TLS2_k127_2871552_6	562743.JH976435_gene2772	4.08e-82	287.0	COG4597@1|root,COG4597@2|Bacteria,1U5AA@1239|Firmicutes,4HD9P@91061|Bacilli	91061|Bacilli	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K09970	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
TLS2_k127_2871552_2	1313172.YM304_29130	8.463e-105	352.0	COG0834@1|root,COG0834@2|Bacteria	2|Bacteria	ET	amino acid transport	-	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
TLS2_k127_2871552_0	469383.Cwoe_2600	5.152e-220	705.0	COG0161@1|root,COG0161@2|Bacteria,2GKF6@201174|Actinobacteria,4CPUF@84995|Rubrobacteria	84995|Rubrobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
TLS2_k127_2871552_5	1380347.JNII01000008_gene4082	6.251e-92	321.0	COG1177@1|root,COG1177@2|Bacteria,2GJ6Q@201174|Actinobacteria,4ESYW@85013|Frankiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS2_k127_2871552_4	1380347.JNII01000008_gene4083	2.888e-101	337.0	COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria,4ET85@85013|Frankiales	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	potB	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS2_k127_2871552_3	1380347.JNII01000008_gene4085	4.94e-104	348.0	COG0687@1|root,COG0687@2|Bacteria,2GKVG@201174|Actinobacteria,4ESHI@85013|Frankiales	201174|Actinobacteria	E	PFAM extracellular solute-binding protein family 1	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_6,SBP_bac_8
TLS2_k127_2885214_3	330214.NIDE0018	1.024e-34	141.0	COG1018@1|root,COG1018@2|Bacteria,3J196@40117|Nitrospirae	40117|Nitrospirae	C	Oxidoreductase NAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2885214_1	909663.KI867150_gene68	2.91e-110	377.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MRH3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
TLS2_k127_2885214_6	760568.Desku_1494	7.786e-11	71.0	COG3937@1|root,COG3937@2|Bacteria,1VF6E@1239|Firmicutes,24QR5@186801|Clostridia,2635Z@186807|Peptococcaceae	186801|Clostridia	S	ATP synthase, subunit b	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
TLS2_k127_2885214_0	469383.Cwoe_3183	9.141e-168	560.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4CPTZ@84995|Rubrobacteria	84995|Rubrobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_2885214_5	1122939.ATUD01000005_gene2686	6.903e-14	86.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4CPTZ@84995|Rubrobacteria	84995|Rubrobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS2_k127_2885214_4	926692.AZYG01000048_gene2707	9.318e-17	83.0	COG1862@1|root,COG1862@2|Bacteria,1VEMC@1239|Firmicutes,24MMT@186801|Clostridia,3WAWM@53433|Halanaerobiales	186801|Clostridia	U	TIGRFAM preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TLS2_k127_2885214_2	266117.Rxyl_1330	6.844e-84	286.0	COG0343@1|root,COG0343@2|Bacteria,2GMWY@201174|Actinobacteria,4CPB3@84995|Rubrobacteria	84995|Rubrobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
TLS2_k127_2885742_0	525904.Tter_0977	6.261e-214	682.0	COG0060@1|root,COG0060@2|Bacteria,2NNT5@2323|unclassified Bacteria	2|Bacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_0027,iPC815.YPO0475	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
TLS2_k127_2885742_4	1157637.KB892091_gene5273	1.785e-33	133.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria	201174|Actinobacteria	O	belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS2_k127_2885742_9	400682.PAC_15727237	2.807e-13	77.0	COG0664@1|root,KOG1113@2759|Eukaryota,38GS1@33154|Opisthokonta,3BESA@33208|Metazoa	33208|Metazoa	T	cAMP-dependent protein kinase regulator activity	PRKAR2B	GO:0000086,GO:0000166,GO:0000278,GO:0001664,GO:0001674,GO:0001932,GO:0001933,GO:0001934,GO:0003008,GO:0003014,GO:0003091,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005929,GO:0005952,GO:0006082,GO:0006469,GO:0006629,GO:0006631,GO:0006950,GO:0006996,GO:0007049,GO:0007154,GO:0007165,GO:0007346,GO:0007596,GO:0007599,GO:0007610,GO:0007611,GO:0007612,GO:0008150,GO:0008152,GO:0008603,GO:0009410,GO:0009611,GO:0009719,GO:0009725,GO:0009892,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010389,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010720,GO:0014070,GO:0015630,GO:0016020,GO:0016043,GO:0017076,GO:0019207,GO:0019210,GO:0019220,GO:0019222,GO:0019752,GO:0019866,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0022402,GO:0022406,GO:0022607,GO:0023052,GO:0030030,GO:0030031,GO:0030104,GO:0030234,GO:0030291,GO:0030315,GO:0030425,GO:0030551,GO:0030552,GO:0030554,GO:0031090,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0031401,GO:0031588,GO:0031625,GO:0031690,GO:0031698,GO:0031966,GO:0031967,GO:0031975,GO:0032147,GO:0032268,GO:0032269,GO:0032270,GO:0032501,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032870,GO:0032991,GO:0033673,GO:0033674,GO:0033762,GO:0034199,GO:0034236,GO:0035556,GO:0036094,GO:0036477,GO:0042060,GO:0042221,GO:0042325,GO:0042326,GO:0042327,GO:0042383,GO:0042493,GO:0042585,GO:0042592,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043025,GO:0043073,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043197,GO:0043198,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043434,GO:0043436,GO:0043549,GO:0043900,GO:0043902,GO:0043933,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044297,GO:0044309,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0044770,GO:0044772,GO:0044782,GO:0044839,GO:0044853,GO:0045121,GO:0045202,GO:0045595,GO:0045597,GO:0045787,GO:0045859,GO:0045860,GO:0045936,GO:0045937,GO:0046983,GO:0048471,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048871,GO:0048878,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050817,GO:0050877,GO:0050878,GO:0050890,GO:0050891,GO:0050896,GO:0051018,GO:0051094,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051239,GO:0051240,GO:0051246,GO:0051247,GO:0051248,GO:0051259,GO:0051291,GO:0051338,GO:0051347,GO:0051348,GO:0051445,GO:0051446,GO:0051640,GO:0051641,GO:0051716,GO:0051726,GO:0060255,GO:0060271,GO:0060281,GO:0060282,GO:0060284,GO:0061695,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0070925,GO:0071310,GO:0071375,GO:0071377,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071900,GO:0071901,GO:0071944,GO:0080090,GO:0090068,GO:0097159,GO:0097332,GO:0097338,GO:0097367,GO:0097447,GO:0097458,GO:0097546,GO:0097711,GO:0098589,GO:0098590,GO:0098772,GO:0098794,GO:0098805,GO:0098857,GO:0120025,GO:0120031,GO:0120036,GO:0120038,GO:0140056,GO:1900193,GO:1900195,GO:1901265,GO:1901363,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901987,GO:1901990,GO:1902494,GO:1902749,GO:1902911,GO:1903047,GO:1903429,GO:1903431,GO:1903538,GO:1904146,GO:1905879,GO:1905881,GO:1990234,GO:2000241,GO:2000243,GO:2000479,GO:2000480	-	ko:K04739	ko04910,map04910	-	-	-	ko00000,ko00001	-	-	-	RIIa,cNMP_binding
TLS2_k127_2885742_2	330084.JNYZ01000014_gene6222	4.62e-105	347.0	COG1680@1|root,COG1680@2|Bacteria,2GNVX@201174|Actinobacteria,4DY2B@85010|Pseudonocardiales	201174|Actinobacteria	V	Beta-lactamase class C	bla	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS2_k127_2885742_5	1223543.GP2_033_00310	1.813e-33	145.0	COG0251@1|root,COG5637@1|root,COG0251@2|Bacteria,COG5637@2|Bacteria,2IN7X@201174|Actinobacteria,4GEKW@85026|Gordoniaceae	201174|Actinobacteria	J	polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_2885742_1	1380390.JIAT01000009_gene709	4.777e-109	366.0	COG2170@1|root,COG2170@2|Bacteria,2GKAA@201174|Actinobacteria,4CPB8@84995|Rubrobacteria	84995|Rubrobacteria	S	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
TLS2_k127_2885742_7	504728.K649_11275	4.568e-20	105.0	COG1225@1|root,COG1225@2|Bacteria,1WKA8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS2_k127_2885742_6	1288079.AUKN01000006_gene3181	1.181e-23	111.0	2BYGI@1|root,333FU@2|Bacteria,2GRMH@201174|Actinobacteria	201174|Actinobacteria	S	Subtilisin inhibitor-like	-	-	-	-	-	-	-	-	-	-	-	-	SSI
TLS2_k127_2885742_10	570268.ANBB01000039_gene3259	6.584e-11	75.0	COG1228@1|root,COG4946@1|root,COG1228@2|Bacteria,COG4946@2|Bacteria,2I3FC@201174|Actinobacteria	201174|Actinobacteria	Q	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
TLS2_k127_2885742_3	269799.Gmet_1196	3.243e-35	153.0	COG2815@1|root,COG2815@2|Bacteria,1RIP7@1224|Proteobacteria,42XQG@68525|delta/epsilon subdivisions,2WT9P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
TLS2_k127_2885742_8	694431.DESACE_08930	1.237e-16	80.0	2E7HQ@1|root,33207@2|Bacteria,1NCYR@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF4231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4231
TLS2_k127_2918933_1	479434.Sthe_2024	1.793e-145	472.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,2G698@200795|Chloroflexi,27YAJ@189775|Thermomicrobia	189775|Thermomicrobia	E	Cysteine synthase	-	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738,ko:K12339	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03132,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_2918933_0	883156.HMPREF9282_00880	6.074e-148	484.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,4H34D@909932|Negativicutes	909932|Negativicutes	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
TLS2_k127_2918933_2	555088.DealDRAFT_1870	4.597e-38	145.0	COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,42JYX@68298|Syntrophomonadaceae	186801|Clostridia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04225	Formyl_trans_N
TLS2_k127_2932179_2	110319.CF8_0803	4.59e-131	432.0	COG5276@1|root,COG5276@2|Bacteria,2IAAZ@201174|Actinobacteria	201174|Actinobacteria	O	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD,P_proprotein
TLS2_k127_2932179_3	469383.Cwoe_3190	2.695e-111	368.0	COG0598@1|root,COG0598@2|Bacteria,2GKNZ@201174|Actinobacteria,4CR9X@84995|Rubrobacteria	84995|Rubrobacteria	P	CorA-like Mg2+ transporter protein	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
TLS2_k127_2932179_4	580340.Tlie_1873	4.931e-58	205.0	COG0537@1|root,COG0537@2|Bacteria,3TB29@508458|Synergistetes	508458|Synergistetes	FG	PFAM histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
TLS2_k127_2932179_1	1128421.JAGA01000002_gene209	1.544e-153	497.0	COG1109@1|root,COG1109@2|Bacteria,2NNRE@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	manB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iECS88_1305.ECS88_2145,iECUMN_1333.ECUMN_2384,iUTI89_1310.UTI89_C2321	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS2_k127_2932179_0	710696.Intca_0881	0.0	1147.0	COG2866@1|root,COG4412@1|root,COG2866@2|Bacteria,COG4412@2|Bacteria,2GN49@201174|Actinobacteria,4FIMN@85021|Intrasporangiaceae	201174|Actinobacteria	M	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14,Peptidase_M6
TLS2_k127_2932179_6	395495.Lcho_1873	9.141e-17	89.0	COG0824@1|root,COG2153@1|root,COG0824@2|Bacteria,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,2VMR6@28216|Betaproteobacteria,1KJX6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Acetyltransferase (GNAT) domain	yjcF	-	-	-	-	-	-	-	-	-	-	-	4HBT,Acetyltransf_10
TLS2_k127_2932179_5	525904.Tter_2363	1.394e-45	172.0	COG1956@1|root,COG1956@2|Bacteria,2NPKF@2323|unclassified Bacteria	2|Bacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	yebR	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF,GAF_2
TLS2_k127_2934370_0	1430331.EP10_10125	6.762e-131	436.0	COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,4H9YR@91061|Bacilli,1WF39@129337|Geobacillus	91061|Bacilli	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
TLS2_k127_2934370_3	1125863.JAFN01000001_gene2409	5.976e-85	299.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM-1	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
TLS2_k127_2934370_2	469383.Cwoe_1162	8.975e-92	320.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4CPJ9@84995|Rubrobacteria	84995|Rubrobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS2_k127_2934370_1	675635.Psed_4322	1.274e-106	360.0	COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria,4E1GD@85010|Pseudonocardiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_2934370_5	5722.XP_001311320.1	9.671e-08	64.0	COG0664@1|root,KOG1113@2759|Eukaryota	2759|Eukaryota	T	cAMP-dependent protein kinase regulator activity	PRKAR1A	GO:0000003,GO:0000166,GO:0000187,GO:0000226,GO:0000280,GO:0001704,GO:0001707,GO:0001932,GO:0001933,GO:0001934,GO:0002682,GO:0002683,GO:0002694,GO:0002695,GO:0003006,GO:0003008,GO:0003014,GO:0003091,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005929,GO:0005952,GO:0006355,GO:0006357,GO:0006464,GO:0006468,GO:0006469,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0007010,GO:0007015,GO:0007017,GO:0007049,GO:0007143,GO:0007154,GO:0007162,GO:0007163,GO:0007165,GO:0007267,GO:0007268,GO:0007274,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007369,GO:0007389,GO:0007498,GO:0007507,GO:0007591,GO:0007596,GO:0007599,GO:0007610,GO:0007611,GO:0007612,GO:0007613,GO:0007635,GO:0008103,GO:0008150,GO:0008152,GO:0008283,GO:0008285,GO:0008306,GO:0008355,GO:0008603,GO:0009611,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009798,GO:0009887,GO:0009888,GO:0009889,GO:0009892,GO:0009893,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0009994,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010628,GO:0010639,GO:0010646,GO:0010647,GO:0010648,GO:0010721,GO:0010738,GO:0010927,GO:0010948,GO:0014706,GO:0014855,GO:0015630,GO:0016020,GO:0016043,GO:0016310,GO:0016325,GO:0017076,GO:0019207,GO:0019210,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0019932,GO:0019933,GO:0019935,GO:0019953,GO:0021700,GO:0022402,GO:0022407,GO:0022408,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030029,GO:0030036,GO:0030104,GO:0030154,GO:0030155,GO:0030234,GO:0030239,GO:0030291,GO:0030435,GO:0030551,GO:0030552,GO:0030554,GO:0030587,GO:0030951,GO:0030952,GO:0031032,GO:0031154,GO:0031156,GO:0031285,GO:0031288,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031399,GO:0031400,GO:0031401,GO:0031588,GO:0031594,GO:0031625,GO:0032147,GO:0032268,GO:0032269,GO:0032270,GO:0032501,GO:0032502,GO:0032504,GO:0032553,GO:0032555,GO:0032559,GO:0032870,GO:0032878,GO:0032944,GO:0032945,GO:0032989,GO:0032991,GO:0033002,GO:0033043,GO:0033673,GO:0033674,GO:0033762,GO:0034199,GO:0034236,GO:0035265,GO:0035556,GO:0036094,GO:0036211,GO:0040007,GO:0040020,GO:0042048,GO:0042060,GO:0042127,GO:0042129,GO:0042130,GO:0042221,GO:0042303,GO:0042325,GO:0042326,GO:0042327,GO:0042493,GO:0042592,GO:0042692,GO:0042802,GO:0042995,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043405,GO:0043406,GO:0043408,GO:0043410,GO:0043412,GO:0043434,GO:0043549,GO:0043900,GO:0043901,GO:0043934,GO:0043949,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044853,GO:0045121,GO:0045202,GO:0045214,GO:0045471,GO:0045595,GO:0045596,GO:0045786,GO:0045835,GO:0045859,GO:0045860,GO:0045936,GO:0045937,GO:0046006,GO:0046007,GO:0046677,GO:0048285,GO:0048332,GO:0048468,GO:0048469,GO:0048477,GO:0048513,GO:0048518,GO:0048519,GO:0048520,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048589,GO:0048598,GO:0048599,GO:0048609,GO:0048646,GO:0048729,GO:0048731,GO:0048738,GO:0048856,GO:0048869,GO:0048871,GO:0048878,GO:0050670,GO:0050672,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050795,GO:0050817,GO:0050863,GO:0050865,GO:0050866,GO:0050868,GO:0050877,GO:0050878,GO:0050890,GO:0050891,GO:0050896,GO:0051018,GO:0051093,GO:0051128,GO:0051129,GO:0051146,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051248,GO:0051249,GO:0051250,GO:0051252,GO:0051321,GO:0051338,GO:0051347,GO:0051348,GO:0051445,GO:0051447,GO:0051703,GO:0051704,GO:0051716,GO:0051726,GO:0051783,GO:0051784,GO:0055001,GO:0055002,GO:0055017,GO:0060038,GO:0060255,GO:0060259,GO:0060281,GO:0060283,GO:0060284,GO:0060419,GO:0060537,GO:0061061,GO:0061695,GO:0061939,GO:0065007,GO:0065008,GO:0065009,GO:0070663,GO:0070664,GO:0070887,GO:0070925,GO:0071310,GO:0071375,GO:0071377,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071900,GO:0071901,GO:0071902,GO:0071944,GO:0072359,GO:0072375,GO:0080090,GO:0090036,GO:0090038,GO:0090702,GO:0097159,GO:0097305,GO:0097367,GO:0097435,GO:0097546,GO:0098589,GO:0098590,GO:0098772,GO:0098805,GO:0098857,GO:0098916,GO:0099120,GO:0099536,GO:0099537,GO:0120025,GO:0120038,GO:0140013,GO:1900193,GO:1900194,GO:1901265,GO:1901363,GO:1901564,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902494,GO:1902531,GO:1902532,GO:1902533,GO:1902911,GO:1903037,GO:1903038,GO:1903046,GO:1903429,GO:1903430,GO:1903506,GO:1903538,GO:1905879,GO:1905880,GO:1990234,GO:2000112,GO:2000114,GO:2000241,GO:2000242,GO:2000253,GO:2000479,GO:2000480,GO:2001141	-	ko:K04739	ko04910,map04910	-	-	-	ko00000,ko00001	-	-	-	RIIa,cNMP_binding
TLS2_k127_2934370_4	1157638.KB892170_gene38	5.107e-44	179.0	COG2072@1|root,COG2072@2|Bacteria,2GNGX@201174|Actinobacteria	201174|Actinobacteria	P	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_3
TLS2_k127_2936774_0	1462527.CCDM010000004_gene3292	2.416e-120	394.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,4HAP6@91061|Bacilli,23MTG@182709|Oceanobacillus	91061|Bacilli	C	Transketolase, pyrimidine binding domain	acoB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_2936774_1	351607.Acel_0588	4.868e-90	312.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria,4EUGM@85013|Frankiales	201174|Actinobacteria	C	PFAM catalytic domain of components of various dehydrogenase complexes	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_2936774_6	1346791.M529_17320	4.634e-07	57.0	COG0346@1|root,COG0346@2|Bacteria,1RF1Z@1224|Proteobacteria,2U7I9@28211|Alphaproteobacteria,2K6PI@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_2936774_3	543632.JOJL01000002_gene8256	3.865e-67	251.0	COG3437@1|root,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HD,HD_5
TLS2_k127_2936774_5	1043493.BBLU01000007_gene8	4.242e-12	79.0	2DRIE@1|root,33BXS@2|Bacteria	2|Bacteria	S	Family of unknown function (DUF5317)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5317
TLS2_k127_2936774_4	1380347.JNII01000006_gene1629	1.637e-19	103.0	COG0477@1|root,COG2814@2|Bacteria,2HF67@201174|Actinobacteria,4EWG3@85013|Frankiales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS2_k127_2936774_2	856793.MICA_663	1.139e-68	242.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,4BPMS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009507,GO:0009536,GO:0010035,GO:0010038,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017076,GO:0019866,GO:0030554,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0046686,GO:0046872,GO:0046914,GO:0048046,GO:0050896,GO:0050897,GO:0055114,GO:0070469,GO:0097159,GO:0097367,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS2_k127_2946658_0	469383.Cwoe_0843	4.794e-191	604.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4CPEB@84995|Rubrobacteria	84995|Rubrobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS2_k127_2946658_6	1283299.AUKG01000002_gene4569	2.343e-60	215.0	COG2096@1|root,COG2096@2|Bacteria,2GMHN@201174|Actinobacteria,4CQR4@84995|Rubrobacteria	84995|Rubrobacteria	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
TLS2_k127_2946658_2	266117.Rxyl_2482	1.223e-129	428.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4CPUT@84995|Rubrobacteria	84995|Rubrobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_2946658_3	1246995.AFR_15225	1.193e-122	423.0	COG4292@1|root,COG4292@2|Bacteria,2GJPB@201174|Actinobacteria,4DCVE@85008|Micromonosporales	201174|Actinobacteria	S	Low temperature requirement A	-	-	-	-	-	-	-	-	-	-	-	-	LtrA
TLS2_k127_2946658_7	469383.Cwoe_4475	1.435e-55	208.0	COG3437@1|root,COG3437@2|Bacteria,2I49F@201174|Actinobacteria	201174|Actinobacteria	T	HD-GYP domain	-	-	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	HD_5
TLS2_k127_2946658_5	1489678.RDMS_01250	9.301e-97	325.0	COG1250@1|root,COG1250@2|Bacteria,1WIN8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_2946658_8	644283.Micau_5703	1.569e-31	135.0	COG0596@1|root,COG0596@2|Bacteria,2GNFU@201174|Actinobacteria,4DDT0@85008|Micromonosporales	201174|Actinobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_2946658_1	469383.Cwoe_4643	1.85e-139	458.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CPNX@84995|Rubrobacteria	84995|Rubrobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_2946658_4	469383.Cwoe_1707	2.991e-98	329.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4CSF0@84995|Rubrobacteria	84995|Rubrobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_2946658_9	585531.HMPREF0063_11996	5.363e-23	114.0	28JAE@1|root,2Z957@2|Bacteria,2IFSW@201174|Actinobacteria,4DWYS@85009|Propionibacteriales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS2_k127_2946658_10	1123389.ATXJ01000004_gene1159	3.712e-07	59.0	COG0147@1|root,COG0147@2|Bacteria,1WI8S@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS2_k127_2948506_1	868595.Desca_1186	7.116e-69	238.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia,2612R@186807|Peptococcaceae	186801|Clostridia	U	type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS2_k127_2948506_3	58123.JOFJ01000025_gene3390	4.312e-45	187.0	COG2304@1|root,COG4965@1|root,COG2304@2|Bacteria,COG4965@2|Bacteria,2H577@201174|Actinobacteria	201174|Actinobacteria	U	Type ii secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF,VWA_2
TLS2_k127_2948506_4	33876.JNXY01000037_gene8039	6.002e-37	151.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,4DGT4@85008|Micromonosporales	201174|Actinobacteria	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS2_k127_2948506_6	107635.AZUO01000001_gene1267	1.062e-18	104.0	COG2020@1|root,COG2020@2|Bacteria,1RBFX@1224|Proteobacteria,2U68D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TLS2_k127_2948506_2	1095767.CAHD01000205_gene859	1.926e-47	199.0	COG4254@1|root,COG4733@1|root,COG4254@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	FecR,fn3
TLS2_k127_2948506_0	1122239.AULS01000001_gene1850	1.328e-156	497.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4FM80@85023|Microbacteriaceae	201174|Actinobacteria	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_2959523_1	1121428.DESHY_120057___1	3.048e-90	310.0	COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,25ZZB@186807|Peptococcaceae	186801|Clostridia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
TLS2_k127_2959523_4	469383.Cwoe_2673	3.117e-37	147.0	COG1057@1|root,COG1057@2|Bacteria,2GMFZ@201174|Actinobacteria,4CQ75@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_2959523_5	1380390.JIAT01000002_gene6020	8.809e-31	134.0	COG0799@1|root,COG0799@2|Bacteria,2IKZ3@201174|Actinobacteria,4CQDN@84995|Rubrobacteria	84995|Rubrobacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
TLS2_k127_2959523_6	469383.Cwoe_5806	1.664e-16	87.0	COG1595@1|root,COG1595@2|Bacteria,2HY6G@201174|Actinobacteria,4CQBA@84995|Rubrobacteria	84995|Rubrobacteria	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_2959523_2	1380390.JIAT01000010_gene4865	7.425e-85	289.0	COG2129@1|root,COG2129@2|Bacteria,2GJ72@201174|Actinobacteria	201174|Actinobacteria	S	metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS2_k127_2959523_3	1380390.JIAT01000010_gene4864	3.664e-52	196.0	2DM23@1|root,31DUR@2|Bacteria,2GIYZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	BON,DUF2204,NTP_transf_5
TLS2_k127_2959523_0	1380390.JIAT01000016_gene5650	2.678e-257	807.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4CPVB@84995|Rubrobacteria	84995|Rubrobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
TLS2_k127_2961803_11	1380390.JIAT01000010_gene3345	1.31e-31	127.0	COG4177@1|root,COG4177@2|Bacteria,2GNZK@201174|Actinobacteria,4CTDZ@84995|Rubrobacteria	84995|Rubrobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
TLS2_k127_2961803_6	477641.MODMU_2361	6.461e-113	381.0	COG0683@1|root,COG0683@2|Bacteria,2I9XT@201174|Actinobacteria	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_2961803_7	1380393.JHVP01000005_gene3748	4.816e-102	338.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4EVN5@85013|Frankiales	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_2961803_9	309801.trd_A0080	2.599e-78	269.0	COG0410@1|root,COG0410@2|Bacteria,2G69M@200795|Chloroflexi	200795|Chloroflexi	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_2961803_1	997346.HMPREF9374_2294	3.228e-169	540.0	COG5441@1|root,COG5441@2|Bacteria,1TQ3W@1239|Firmicutes,4HATW@91061|Bacilli,27BD5@186824|Thermoactinomycetaceae	91061|Bacilli	S	Uncharacterised protein family (UPF0261)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0261
TLS2_k127_2961803_2	42256.RradSPS_2933	1.861e-138	464.0	COG5564@1|root,COG5564@2|Bacteria,2GMW9@201174|Actinobacteria,4CSEH@84995|Rubrobacteria	84995|Rubrobacteria	S	Phosphoenolpyruvate hydrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	PEP_hydrolase
TLS2_k127_2961803_13	1396141.BATP01000023_gene694	3.071e-22	110.0	COG1917@1|root,COG1917@2|Bacteria,46WE0@74201|Verrucomicrobia,2IVZR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2961803_5	665959.HMPREF1013_01488	8.613e-121	404.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,4H9UU@91061|Bacilli,1ZCCM@1386|Bacillus	91061|Bacilli	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_2961803_8	1128421.JAGA01000001_gene2209	2.334e-96	324.0	COG1082@1|root,COG1082@2|Bacteria,2NQZX@2323|unclassified Bacteria	2|Bacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS2_k127_2961803_4	1128421.JAGA01000001_gene2210	3.621e-123	421.0	COG5441@1|root,COG5441@2|Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0261)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0261
TLS2_k127_2961803_3	1128421.JAGA01000001_gene2211	6.408e-127	411.0	COG1402@1|root,COG1402@2|Bacteria,2NRPM@2323|unclassified Bacteria	2|Bacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
TLS2_k127_2961803_12	498761.HM1_2674	1.067e-29	128.0	COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,25C4D@186801|Clostridia	186801|Clostridia	K	transcriptional regulator DeoR family	-	-	-	ko:K02081,ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
TLS2_k127_2961803_0	525904.Tter_0155	4.031e-173	574.0	COG1082@1|root,COG1082@2|Bacteria,2NQCG@2323|unclassified Bacteria	2|Bacteria	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS2_k127_2961803_10	525904.Tter_0156	4.662e-72	250.0	COG0673@1|root,COG0673@2|Bacteria,2NQJC@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS2_k127_299031_8	1121106.JQKB01000008_gene1358	4.067e-18	93.0	COG1920@1|root,COG1920@2|Bacteria,1RJPN@1224|Proteobacteria,2UAA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
TLS2_k127_299031_7	1120950.KB892776_gene810	2.744e-28	125.0	COG0491@1|root,COG0491@2|Bacteria,2H8JM@201174|Actinobacteria,4DSJJ@85009|Propionibacteriales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red,Lactamase_B
TLS2_k127_299031_1	36809.MAB_3909	6.048e-232	732.0	COG2373@1|root,COG2373@2|Bacteria,2H4M3@201174|Actinobacteria,236MB@1762|Mycobacteriaceae	201174|Actinobacteria	S	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Catalase
TLS2_k127_299031_2	446471.Xcel_3009	1.412e-93	316.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria,4F40W@85017|Promicromonosporaceae	201174|Actinobacteria	S	Uncharacterised protein family UPF0052	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
TLS2_k127_299031_6	1463855.JOHV01000020_gene3028	3.146e-35	142.0	COG2085@1|root,COG2085@2|Bacteria,2IKF2@201174|Actinobacteria	201174|Actinobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	-	-	-	-	-	-	-	-	-	-	F420_oxidored
TLS2_k127_299031_3	42256.RradSPS_0871	5.04e-63	227.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4CQ5F@84995|Rubrobacteria	84995|Rubrobacteria	C	F420-0:Gamma-glutamyl ligase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
TLS2_k127_299031_5	1150864.MILUP08_40163	1.081e-52	202.0	COG0586@1|root,COG0586@2|Bacteria,2HKKQ@201174|Actinobacteria,4DDXT@85008|Micromonosporales	201174|Actinobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_299031_0	85643.Tmz1t_1660	0.0	1639.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2VKIR@28216|Betaproteobacteria,2KVIK@206389|Rhodocyclales	206389|Rhodocyclales	E	Bacterial NAD-glutamate dehydrogenase	gdh	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
TLS2_k127_299031_4	867903.ThesuDRAFT_02229	5.092e-57	201.0	COG1225@1|root,COG1225@2|Bacteria,1V3N5@1239|Firmicutes,24HP8@186801|Clostridia,3WDA9@538999|Clostridiales incertae sedis	186801|Clostridia	O	Redoxin	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS2_k127_2998688_6	649639.Bcell_1138	4.294e-22	104.0	2EBQY@1|root,335QW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2998688_2	469383.Cwoe_5420	1.346e-65	238.0	COG1376@1|root,COG1376@2|Bacteria,2INDP@201174|Actinobacteria,4CSQ2@84995|Rubrobacteria	84995|Rubrobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS2_k127_2998688_3	1283299.AUKG01000001_gene2725	1.823e-41	169.0	COG1633@1|root,COG1633@2|Bacteria,2GQ6Z@201174|Actinobacteria	201174|Actinobacteria	S	(twin-arginine translocation) pathway signal	-	-	-	-	-	-	-	-	-	-	-	-	Ferritin_2
TLS2_k127_2998688_4	1283299.AUKG01000001_gene2726	3.633e-28	130.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin_2
TLS2_k127_2998688_7	391038.Bphy_3260	3.922e-08	61.0	2DR83@1|root,33AMK@2|Bacteria,1NJYX@1224|Proteobacteria,2VXU5@28216|Betaproteobacteria,1K72P@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2998688_8	1121928.AUHE01000012_gene1424	0.0004646	47.0	COG1396@1|root,COG3800@1|root,COG1396@2|Bacteria,COG3800@2|Bacteria,2GMWU@201174|Actinobacteria,4GC59@85026|Gordoniaceae	201174|Actinobacteria	K	IrrE N-terminal-like domain	ramB	GO:0001666,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0036293,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070482,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07110	-	-	-	-	ko00000,ko03000	-	-	-	DUF2083,HTH_19,HTH_3,HTH_31,Peptidase_M78
TLS2_k127_2998688_0	469383.Cwoe_3494	1.186e-171	572.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,4CS9W@84995|Rubrobacteria	84995|Rubrobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
TLS2_k127_2998688_1	1121468.AUBR01000029_gene1577	8.01e-116	385.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,42FDK@68295|Thermoanaerobacterales	186801|Clostridia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06430	GcpE
TLS2_k127_2998688_5	1380390.JIAT01000010_gene4549	2.759e-24	107.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4CPEE@84995|Rubrobacteria	84995|Rubrobacteria	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
TLS2_k127_2999447_3	1172188.KB911820_gene2633	2.209e-60	212.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4FG4H@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Multicopper oxidase	-	-	1.3.3.5	ko:K08100	ko00860,ko01110,map00860,map01110	-	R02394	RC01983	ko00000,ko00001,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
TLS2_k127_2999447_6	1380390.JIAT01000010_gene4022	4.076e-41	155.0	COG0662@1|root,COG0662@2|Bacteria,2HRBD@201174|Actinobacteria,4CT8K@84995|Rubrobacteria	84995|Rubrobacteria	G	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_2999447_5	1231185.BAMP01000090_gene2462	2.492e-42	158.0	COG0662@1|root,COG0662@2|Bacteria,1RHWU@1224|Proteobacteria,2UA4V@28211|Alphaproteobacteria,43RCI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_2999447_4	91464.S7335_5367	7.496e-45	172.0	COG1846@1|root,COG1846@2|Bacteria,1G61S@1117|Cyanobacteria,1H2B8@1129|Synechococcus	1117|Cyanobacteria	K	Transcriptional regulator, MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS2_k127_2999447_2	298655.KI912266_gene6021	1.831e-89	321.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_2999447_1	196162.Noca_1019	2.931e-130	426.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria,4DU2Z@85009|Propionibacteriales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_2999447_0	469383.Cwoe_3388	3.682e-232	742.0	COG1366@1|root,COG2409@1|root,COG1366@2|Bacteria,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4CR8Y@84995|Rubrobacteria	84995|Rubrobacteria	T	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	MMPL,STAS_2
TLS2_k127_3001354_1	926560.KE387023_gene2373	3.425e-178	566.0	COG0001@1|root,COG0001@2|Bacteria,1WM90@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_3001354_7	306281.AJLK01000102_gene3405	5.253e-50	199.0	COG2258@1|root,COG2258@2|Bacteria,1GE7I@1117|Cyanobacteria	1117|Cyanobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3001354_5	1172180.KB911800_gene3296	1.882e-91	314.0	COG2321@1|root,COG2321@2|Bacteria,2H3UT@201174|Actinobacteria	201174|Actinobacteria	S	Neutral zinc metallopeptidase	ypfJ	GO:0005575,GO:0005576	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
TLS2_k127_3001354_0	42256.RradSPS_0972	6.622e-248	787.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,2GIT4@201174|Actinobacteria,4CPXB@84995|Rubrobacteria	84995|Rubrobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05565	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
TLS2_k127_3001354_9	469383.Cwoe_1203	1.006e-31	130.0	COG2111@1|root,COG2111@2|Bacteria,2IP04@201174|Actinobacteria,4CTMX@84995|Rubrobacteria	84995|Rubrobacteria	P	Na H antiporter MnhB subunit-related protein	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MnhB
TLS2_k127_3001354_11	266117.Rxyl_3146	1.071e-29	129.0	COG1006@1|root,COG1006@2|Bacteria,2ISBC@201174|Actinobacteria,4CQW3@84995|Rubrobacteria	84995|Rubrobacteria	P	PFAM NADH-ubiquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
TLS2_k127_3001354_2	469383.Cwoe_1205	2.744e-163	533.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria,4CQ74@84995|Rubrobacteria	84995|Rubrobacteria	CP	NADH ubiquinone plastoquinone	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
TLS2_k127_3001354_8	42256.RradSPS_0976	3.376e-32	145.0	COG1863@1|root,COG1863@2|Bacteria,2IT9T@201174|Actinobacteria,4CTPK@84995|Rubrobacteria	84995|Rubrobacteria	P	Cation antiporter	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
TLS2_k127_3001354_12	266117.Rxyl_1796	6.23e-23	107.0	COG2212@1|root,COG2212@2|Bacteria,2GTPK@201174|Actinobacteria,4CTVY@84995|Rubrobacteria	84995|Rubrobacteria	P	Multiple resistance and pH regulation protein F	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
TLS2_k127_3001354_10	42256.RradSPS_0978	3.652e-31	130.0	COG1320@1|root,COG1320@2|Bacteria,2HRRR@201174|Actinobacteria,4CTUG@84995|Rubrobacteria	84995|Rubrobacteria	P	Na H antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
TLS2_k127_3001354_6	469383.Cwoe_0821	1.601e-82	284.0	COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,4CPW1@84995|Rubrobacteria	84995|Rubrobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
TLS2_k127_3001354_13	1220535.IMCC14465_14270	1.621e-13	82.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,4BQYF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
TLS2_k127_3001354_4	710111.FraQA3DRAFT_5066	1.1e-99	349.0	COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,4ERID@85013|Frankiales	201174|Actinobacteria	F	SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01923,ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
TLS2_k127_3001354_3	1121468.AUBR01000026_gene2957	5.759e-124	407.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,2485N@186801|Clostridia,42FJ7@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
TLS2_k127_3008623_3	1380390.JIAT01000009_gene1180	1.412e-36	154.0	COG0454@1|root,COG1042@1|root,COG0456@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4CSAB@84995|Rubrobacteria	84995|Rubrobacteria	CK	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
TLS2_k127_3008623_4	1463856.JOHY01000002_gene1172	1.67e-09	69.0	COG0589@1|root,COG0589@2|Bacteria,2IQPQ@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_3008623_2	118163.Ple7327_2337	1.98e-60	215.0	COG1853@1|root,COG1853@2|Bacteria,1G4QZ@1117|Cyanobacteria	1117|Cyanobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TLS2_k127_3008623_0	118163.Ple7327_2338	2.35e-112	374.0	COG0624@1|root,COG0624@2|Bacteria,1G3WM@1117|Cyanobacteria	1117|Cyanobacteria	E	peptidase dimerisation domain	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_3008623_1	42256.RradSPS_2500	3.267e-91	326.0	COG3367@1|root,COG3367@2|Bacteria	2|Bacteria	M	COGs COG3367 conserved	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1611,DUF1611_N,Peptidase_S8
TLS2_k127_3014153_2	1408254.T458_13050	1.083e-73	257.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,4HBEA@91061|Bacilli,26T8K@186822|Paenibacillaceae	91061|Bacilli	C	(E1) component, eukaryotic type, alpha subunit	acoA	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
TLS2_k127_3014153_0	1283299.AUKG01000002_gene4806	9.783e-189	615.0	COG0072@1|root,COG0072@2|Bacteria,2GMFD@201174|Actinobacteria,4CP7V@84995|Rubrobacteria	84995|Rubrobacteria	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
TLS2_k127_3014153_1	445972.ANACOL_03422	2.841e-104	348.0	COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,3WGWV@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
TLS2_k127_3027652_3	159087.Daro_3370	2.053e-65	231.0	COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,2VIX1@28216|Betaproteobacteria,2KV29@206389|Rhodocyclales	206389|Rhodocyclales	S	NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
TLS2_k127_3027652_5	665959.HMPREF1013_02782	5.003e-50	197.0	COG5276@1|root,COG5276@2|Bacteria,1UUVN@1239|Firmicutes,4HBJX@91061|Bacilli,1ZE6M@1386|Bacillus	91061|Bacilli	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_3027652_8	760142.Hipma_0222	3.8e-32	129.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,42TZA@68525|delta/epsilon subdivisions,2WQCU@28221|Deltaproteobacteria,2M78V@213113|Desulfurellales	28221|Deltaproteobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
TLS2_k127_3027652_2	469383.Cwoe_1600	6.277e-79	274.0	COG0388@1|root,COG0388@2|Bacteria,2GMQA@201174|Actinobacteria,4CPAW@84995|Rubrobacteria	84995|Rubrobacteria	S	Carbon-nitrogen hydrolase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
TLS2_k127_3027652_11	321332.CYB_2318	2.824e-16	88.0	COG1011@1|root,COG1011@2|Bacteria,1G51I@1117|Cyanobacteria,1H0H2@1129|Synechococcus	1117|Cyanobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
TLS2_k127_3027652_13	1214065.BAGV01000021_gene2801	8.139e-13	75.0	COG3837@1|root,COG3837@2|Bacteria,1N15Q@1224|Proteobacteria,1T07G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_3027652_0	649747.HMPREF0083_02151	4.841e-156	501.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HB0J@91061|Bacilli,26QCJ@186822|Paenibacillaceae	91061|Bacilli	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3027652_7	42256.RradSPS_1771	2.282e-32	138.0	COG1472@1|root,COG1472@2|Bacteria,2GM43@201174|Actinobacteria,4CQHG@84995|Rubrobacteria	84995|Rubrobacteria	G	glycoside hydrolase, family	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
TLS2_k127_3027652_4	1123320.KB889719_gene7341	1.231e-55	219.0	COG2720@1|root,COG2720@2|Bacteria,2GISH@201174|Actinobacteria	201174|Actinobacteria	V	vancomycin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
TLS2_k127_3027652_12	1313172.YM304_33950	2.618e-15	85.0	COG0824@1|root,COG0824@2|Bacteria	2|Bacteria	IQ	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
TLS2_k127_3027652_10	862751.SACTE_5261	1.108e-23	112.0	COG3206@1|root,COG3206@2|Bacteria,2GPMH@201174|Actinobacteria	201174|Actinobacteria	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
TLS2_k127_3027652_6	1242864.D187_004572	3.71e-49	195.0	COG1597@1|root,COG1597@2|Bacteria,1RCJT@1224|Proteobacteria,42W6W@68525|delta/epsilon subdivisions,2X6V3@28221|Deltaproteobacteria,2YUYD@29|Myxococcales	28221|Deltaproteobacteria	I	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS2_k127_3027652_1	266117.Rxyl_0606	2.322e-88	301.0	COG0813@1|root,COG0813@2|Bacteria,2GNT6@201174|Actinobacteria,4CU45@84995|Rubrobacteria	84995|Rubrobacteria	F	Phosphorylase superfamily	-	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03784	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_3027652_9	269800.Tfu_0751	5.981e-31	132.0	COG3393@1|root,COG3393@2|Bacteria,2GMD2@201174|Actinobacteria,4EFMK@85012|Streptosporangiales	201174|Actinobacteria	S	Domain of unknown function (DUF4081)	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,DUF4081,FR47
TLS2_k127_3035370_2	1382306.JNIM01000001_gene1704	1.496e-129	425.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS2_k127_3035370_0	243233.MCA2161	3.97e-195	652.0	COG3206@1|root,COG3206@2|Bacteria,1QX0J@1224|Proteobacteria,1RZ5A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3035370_1	926550.CLDAP_27920	4.337e-134	466.0	COG1858@1|root,COG2133@1|root,COG1858@2|Bacteria,COG2133@2|Bacteria,2G989@200795|Chloroflexi	200795|Chloroflexi	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG
TLS2_k127_3035370_3	1122939.ATUD01000001_gene317	7.054e-106	368.0	COG4214@1|root,COG4214@2|Bacteria,2GJAH@201174|Actinobacteria,4CS8K@84995|Rubrobacteria	84995|Rubrobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
TLS2_k127_3035370_4	1122939.ATUD01000001_gene318	4.825e-105	347.0	COG1129@1|root,COG1129@2|Bacteria,2GJDV@201174|Actinobacteria,4CR9Y@84995|Rubrobacteria	84995|Rubrobacteria	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10545	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4	-	-	ABC_tran
TLS2_k127_3042446_10	1306174.JODP01000001_gene5139	1.134e-25	118.0	2FC5S@1|root,3449M@2|Bacteria,2H9NP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3042446_6	1306174.JODP01000013_gene7518	1.269e-46	188.0	COG1989@1|root,COG1989@2|Bacteria,2GJ7K@201174|Actinobacteria	201174|Actinobacteria	NOU	Peptidase A24A, prepilin type IV	pppA	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
TLS2_k127_3042446_1	1095772.CAHH01000042_gene1237	2.473e-152	501.0	COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria	201174|Actinobacteria	NU	type II secretion system protein E	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
TLS2_k127_3042446_8	469383.Cwoe_1666	2.136e-36	157.0	COG0739@1|root,COG0741@1|root,COG0739@2|Bacteria,COG0741@2|Bacteria,2I2XS@201174|Actinobacteria,4CPBG@84995|Rubrobacteria	84995|Rubrobacteria	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23,SLT_2
TLS2_k127_3042446_2	42256.RradSPS_0866	2.524e-112	392.0	COG2805@1|root,COG2805@2|Bacteria,2HPWY@201174|Actinobacteria,4CP76@84995|Rubrobacteria	84995|Rubrobacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TLS2_k127_3042446_4	1463887.KL589992_gene377	2.828e-81	290.0	COG0515@1|root,COG0515@2|Bacteria,2GNXG@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	pknJ	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_3042446_5	1206729.BAFZ01000054_gene3045	8.969e-54	199.0	COG0515@1|root,COG0515@2|Bacteria,2GNXG@201174|Actinobacteria,4FW88@85025|Nocardiaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	pknD	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,Pro_isomerase
TLS2_k127_3042446_14	1507.HMPREF0262_03554	1.05e-05	52.0	COG1476@1|root,COG1476@2|Bacteria,1V7TA@1239|Firmicutes,2496Q@186801|Clostridia,36VFV@31979|Clostridiaceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	HTH_3
TLS2_k127_3042446_3	251221.35211202	1.688e-85	305.0	COG3119@1|root,COG3119@2|Bacteria,1G5IZ@1117|Cyanobacteria	1117|Cyanobacteria	P	Arylsulfatase a	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase,Sulfatase_C
TLS2_k127_3042446_7	875328.JDM601_3095	1.126e-37	148.0	2AW22@1|root,31MWT@2|Bacteria,2IKWE@201174|Actinobacteria,238T9@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1360)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1360
TLS2_k127_3042446_13	446466.Cfla_2903	1.521e-16	85.0	2DMMR@1|root,32SHV@2|Bacteria,2IQA6@201174|Actinobacteria,4F1GY@85016|Cellulomonadaceae	201174|Actinobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
TLS2_k127_3042446_9	1298863.AUEP01000007_gene271	2.155e-36	157.0	COG1225@1|root,COG1225@2|Bacteria,2IC3G@201174|Actinobacteria	201174|Actinobacteria	O	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_3042446_11	1123073.KB899242_gene1525	5.374e-18	89.0	COG0053@1|root,COG0053@2|Bacteria,1N8A3@1224|Proteobacteria,1SDJW@1236|Gammaproteobacteria,1XB32@135614|Xanthomonadales	135614|Xanthomonadales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3042446_0	42256.RradSPS_2485	1.339e-185	597.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4CRNM@84995|Rubrobacteria	84995|Rubrobacteria	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
TLS2_k127_3042446_12	1283299.AUKG01000001_gene3172	6.946e-18	86.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4CPCB@84995|Rubrobacteria	84995|Rubrobacteria	EQ	Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
TLS2_k127_3042470_3	867903.ThesuDRAFT_02229	7.043e-44	162.0	COG1225@1|root,COG1225@2|Bacteria,1V3N5@1239|Firmicutes,24HP8@186801|Clostridia,3WDA9@538999|Clostridiales incertae sedis	186801|Clostridia	O	Redoxin	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS2_k127_3042470_0	656024.FsymDg_2976	2.205e-99	351.0	COG0515@1|root,COG3391@1|root,COG0515@2|Bacteria,COG3391@2|Bacteria,2GMPZ@201174|Actinobacteria,4ESG4@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	NHL,Pkinase
TLS2_k127_3042470_2	40571.JOEA01000009_gene3204	3.786e-58	227.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria,4DY9N@85010|Pseudonocardiales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027,ko:K10232	ko02010,map02010	M00201,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1,SBP_bac_8
TLS2_k127_3042470_1	1172181.KB911699_gene1645	7.606e-72	269.0	COG0515@1|root,COG0515@2|Bacteria,2GNXG@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	pknJ	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_304821_0	266117.Rxyl_1158	1.325e-13	79.0	COG4968@1|root,COG4968@2|Bacteria,2I4BD@201174|Actinobacteria,4CU66@84995|Rubrobacteria	84995|Rubrobacteria	NU	Cell motility and secretion Intracellular trafficking and secretion	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
TLS2_k127_3053627_11	68260.JOAY01000022_gene1741	2.689e-15	76.0	COG3813@1|root,COG3813@2|Bacteria,2GRIY@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1272)	-	-	-	ko:K09984	-	-	-	-	ko00000	-	-	-	DUF1272
TLS2_k127_3053627_3	469383.Cwoe_4683	6.594e-135	439.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CS51@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_3053627_15	1120919.AUBI01000001_gene2967	0.000564	51.0	COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria,2JPRT@204441|Rhodospirillales	204441|Rhodospirillales	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
TLS2_k127_3053627_2	1192034.CAP_7098	2.835e-146	481.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,1MW7H@1224|Proteobacteria,42NEC@68525|delta/epsilon subdivisions,2WK08@28221|Deltaproteobacteria,2YUA5@29|Myxococcales	28221|Deltaproteobacteria	HP	domain protein	moeB1	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
TLS2_k127_3053627_5	485913.Krac_6681	8.283e-108	363.0	COG0031@1|root,COG0031@2|Bacteria,2G698@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738,ko:K12339	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03132,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_3053627_14	1382356.JQMP01000003_gene1356	1.854e-07	64.0	COG1310@1|root,COG1310@2|Bacteria,2G7CC@200795|Chloroflexi,27YR1@189775|Thermomicrobia	189775|Thermomicrobia	S	JAB/MPN domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
TLS2_k127_3053627_4	1132442.KB889752_gene2674	8.525e-131	428.0	COG0697@1|root,COG0697@2|Bacteria,1UYTR@1239|Firmicutes,4IE0S@91061|Bacilli,1ZFN9@1386|Bacillus	91061|Bacilli	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_3053627_10	270374.MELB17_05162	4.875e-19	101.0	2ECDH@1|root,336BR@2|Bacteria,1N6TI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3053627_8	383372.Rcas_2409	1.003e-42	170.0	COG1853@1|root,COG1853@2|Bacteria,2G8Z4@200795|Chloroflexi,377AM@32061|Chloroflexia	32061|Chloroflexia	S	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TLS2_k127_3053627_12	1192034.CAP_8672	2.032e-13	81.0	COG2905@1|root,COG3202@1|root,COG2905@2|Bacteria,COG3202@2|Bacteria,1RERN@1224|Proteobacteria	1224|Proteobacteria	T	Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
TLS2_k127_3053627_0	330084.JNYZ01000006_gene1399	3.247e-316	1030.0	COG0404@1|root,COG3665@1|root,COG0404@2|Bacteria,COG3665@2|Bacteria,2GJ47@201174|Actinobacteria,4DXZ6@85010|Pseudonocardiales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	-	-	-	-	-	-	-	-	-	-	-	-	DUF1989,FAO_M,GCV_T,GCV_T_C
TLS2_k127_3053627_1	1123023.JIAI01000007_gene1957	9.242e-231	722.0	COG1960@1|root,COG1960@2|Bacteria,2GZNN@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3053627_6	479434.Sthe_1848	6.546e-81	287.0	COG1253@1|root,COG1253@2|Bacteria,2G6DE@200795|Chloroflexi,27YYU@189775|Thermomicrobia	189775|Thermomicrobia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_3053627_7	926569.ANT_12490	1.547e-46	175.0	COG2197@1|root,COG2197@2|Bacteria,2G6T1@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_3053627_13	1380390.JIAT01000010_gene3697	4.009e-12	78.0	COG2199@1|root,COG4585@1|root,COG2199@2|Bacteria,COG4585@2|Bacteria,2IE6K@201174|Actinobacteria,4CR2U@84995|Rubrobacteria	84995|Rubrobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3,PAS
TLS2_k127_3053627_9	266117.Rxyl_1349	1.723e-20	96.0	COG1053@1|root,COG1053@2|Bacteria,2ICBE@201174|Actinobacteria,4CSY4@84995|Rubrobacteria	84995|Rubrobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
TLS2_k127_3058656_0	469383.Cwoe_1837	2.607e-67	233.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4CPHC@84995|Rubrobacteria	84995|Rubrobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
TLS2_k127_3058656_2	326427.Cagg_2683	4.772e-55	223.0	COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,2G66G@200795|Chloroflexi,3754U@32061|Chloroflexia	32061|Chloroflexia	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,PAS
TLS2_k127_3058656_3	696281.Desru_3313	6.856e-30	123.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,2605V@186807|Peptococcaceae	186801|Clostridia	K	PFAM response regulator receiver	phoB	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_3058656_1	1304865.JAGF01000001_gene1387	6.442e-63	231.0	COG0697@1|root,COG0697@2|Bacteria,2GKVT@201174|Actinobacteria	201174|Actinobacteria	EG	Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_30627_2	1121028.ARQE01000012_gene406	4.394e-54	199.0	2AP53@1|root,31E6R@2|Bacteria,1Q6T5@1224|Proteobacteria,2TVR4@28211|Alphaproteobacteria,2PKY7@255475|Aurantimonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_30627_0	1120960.ATXG01000001_gene1108	8.33e-209	678.0	COG2936@1|root,COG2936@2|Bacteria,2GJ2K@201174|Actinobacteria	201174|Actinobacteria	E	dipeptidyl-peptidase	-	-	3.4.14.11	ko:K01281	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PepX_C,Peptidase_S15
TLS2_k127_30627_1	58344.JOEL01000005_gene4338	3.702e-119	395.0	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria	201174|Actinobacteria	EK	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs	-	-	-	ko:K05825,ko:K18907	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	M00700,M00702	R01939	RC00006	ko00000,ko00001,ko00002,ko01000,ko01504,ko03000	-	-	-	Aminotran_1_2,GntR
TLS2_k127_3066721_0	1123023.JIAI01000001_gene6661	1.554e-107	354.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4DXRB@85010|Pseudonocardiales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinP	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
TLS2_k127_3066721_1	1386089.N865_17375	1.018e-44	183.0	COG1073@1|root,COG1073@2|Bacteria,2I0E5@201174|Actinobacteria,4FJN1@85021|Intrasporangiaceae	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TLS2_k127_3066721_2	397287.C807_01232	2.665e-12	80.0	28H77@1|root,2Z7JH@2|Bacteria,1UZ9E@1239|Firmicutes,247WR@186801|Clostridia,27RCV@186928|unclassified Lachnospiraceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3083632_5	1380390.JIAT01000009_gene598	1.089e-60	215.0	COG1744@1|root,COG1744@2|Bacteria,2GMFS@201174|Actinobacteria,4CQBS@84995|Rubrobacteria	84995|Rubrobacteria	S	Basic membrane lipoprotein	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
TLS2_k127_3083632_0	997346.HMPREF9374_0677	3.923e-184	596.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,4HVSH@91061|Bacilli,27B9I@186824|Thermoactinomycetaceae	91061|Bacilli	S	ATPases associated with a variety of cellular activities	mglA	-	3.6.3.17	ko:K02056,ko:K06400	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TLS2_k127_3083632_1	1283299.AUKG01000002_gene3621	4.691e-118	403.0	COG4603@1|root,COG4603@2|Bacteria,2GKAZ@201174|Actinobacteria,4CQAB@84995|Rubrobacteria	84995|Rubrobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS2_k127_3083632_2	1380390.JIAT01000009_gene595	7.224e-107	377.0	COG1079@1|root,COG1079@2|Bacteria,2GKMB@201174|Actinobacteria,4CPYV@84995|Rubrobacteria	84995|Rubrobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS2_k127_3083632_6	767817.Desgi_1875	2.016e-23	110.0	COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,24M2Q@186801|Clostridia,261QR@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4115)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
TLS2_k127_3083632_3	2074.JNYD01000019_gene2602	1.692e-87	313.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2IQ8T@201174|Actinobacteria,4E4GS@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the CinA family	cinA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
TLS2_k127_3083632_7	1122939.ATUD01000003_gene3642	2.706e-12	79.0	COG1514@1|root,COG1514@2|Bacteria,2HNKJ@201174|Actinobacteria,4CQT5@84995|Rubrobacteria	84995|Rubrobacteria	J	LigT like Phosphoesterase	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
TLS2_k127_3083632_4	1082931.KKY_1845	2.993e-62	216.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2TRPR@28211|Alphaproteobacteria,3N6D6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TLS2_k127_3139601_3	1122939.ATUD01000002_gene1314	2.027e-43	172.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4CQ90@84995|Rubrobacteria	84995|Rubrobacteria	H	Mur ligase family, glutamate ligase domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
TLS2_k127_3139601_0	469383.Cwoe_2652	5.831e-241	768.0	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4CPR8@84995|Rubrobacteria	84995|Rubrobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TLS2_k127_3139601_1	1122622.ATWJ01000002_gene800	1.647e-181	622.0	COG2114@1|root,COG2197@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_3139601_2	1122622.ATWJ01000002_gene800	2.143e-126	433.0	COG2114@1|root,COG2197@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_3149392_2	543526.Htur_1218	4.429e-44	181.0	arCOG06939@1|root,arCOG06939@2157|Archaea,2XWTJ@28890|Euryarchaeota,23VEB@183963|Halobacteria	183963|Halobacteria	S	WbqC-like protein family	-	-	-	-	-	-	-	-	-	-	-	-	WbqC
TLS2_k127_3149392_3	1121439.dsat_1722	5.517e-40	171.0	28HYD@1|root,2Z83U@2|Bacteria,1R5TY@1224|Proteobacteria,43104@68525|delta/epsilon subdivisions,2WWF8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
TLS2_k127_3149392_0	479434.Sthe_2756	4.626e-94	336.0	COG0399@1|root,COG0399@2|Bacteria,2G7XI@200795|Chloroflexi	200795|Chloroflexi	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_3149392_1	1283299.AUKG01000001_gene1664	1.804e-59	224.0	COG1216@1|root,COG1216@2|Bacteria,2HU9H@201174|Actinobacteria,4CPRC@84995|Rubrobacteria	84995|Rubrobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS2_k127_3149392_4	1379698.RBG1_1C00001G1542	9.359e-08	65.0	COG3307@1|root,COG3307@2|Bacteria,2NS19@2323|unclassified Bacteria	2|Bacteria	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TLS2_k127_3164161_1	935565.JAEM01000042_gene1840	1.702e-69	244.0	COG0726@1|root,COG0726@2|Bacteria,1MWYU@1224|Proteobacteria,2VFEE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_3164161_3	420662.Mpe_A0601	8.406e-32	141.0	COG2244@1|root,COG2244@2|Bacteria,1QZ3M@1224|Proteobacteria,2VPWD@28216|Betaproteobacteria,1KNF9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Polysaccharide biosynthesis C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_C
TLS2_k127_3164161_0	1229205.BUPH_04869	1.127e-136	449.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2VMJH@28216|Betaproteobacteria,1K498@119060|Burkholderiaceae	28216|Betaproteobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS2_k127_3164161_2	469383.Cwoe_2602	2.842e-42	164.0	COG1522@1|root,COG1522@2|Bacteria,2GP1P@201174|Actinobacteria,4CTFY@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_AsnC-type
TLS2_k127_3170244_0	886293.Sinac_0210	1.335e-86	297.0	COG0458@1|root,COG0458@2|Bacteria,2IXR6@203682|Planctomycetes	203682|Planctomycetes	F	Carbamoylphosphate synthase large subunit	carB	GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS2_k127_3170244_3	469383.Cwoe_3205	1.998e-39	156.0	COG0543@1|root,COG0543@2|Bacteria,2HQ24@201174|Actinobacteria,4CTMJ@84995|Rubrobacteria	84995|Rubrobacteria	C	Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind
TLS2_k127_3170244_1	1380356.JNIK01000005_gene997	3.155e-63	235.0	COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4ERIP@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14,1.3.5.2	ko:K00254,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01868,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TLS2_k127_3170244_4	469383.Cwoe_3207	3.713e-36	140.0	2AU98@1|root,31JWM@2|Bacteria,2HNY8@201174|Actinobacteria,4CQ7F@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3170244_2	469383.Cwoe_3208	1.054e-44	175.0	COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria,4CQ9S@84995|Rubrobacteria	84995|Rubrobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
TLS2_k127_3170244_5	1408452.JAGZ01000002_gene4548	1.815e-09	68.0	COG1758@1|root,COG1758@2|Bacteria,2IQHU@201174|Actinobacteria,23A0K@1762|Mycobacteriaceae	201174|Actinobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
TLS2_k127_3178042_1	1283299.AUKG01000002_gene4961	1.891e-65	227.0	COG0503@1|root,COG0503@2|Bacteria,2IM7C@201174|Actinobacteria,4CQ53@84995|Rubrobacteria	84995|Rubrobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
TLS2_k127_3178042_2	469383.Cwoe_3490	2.32e-52	199.0	COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria,4CPZY@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1
TLS2_k127_3178042_4	390989.JOEG01000022_gene2304	3.41e-20	98.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4DC6X@85008|Micromonosporales	201174|Actinobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	garA	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
TLS2_k127_3178042_5	1283299.AUKG01000002_gene4958	5.834e-17	83.0	2AUU1@1|root,31KH5@2|Bacteria,2HPC3@201174|Actinobacteria,4CQQ6@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3178042_0	1245475.ANAE01000131_gene333	4.091e-193	626.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,4EFSZ@85012|Streptosporangiales	201174|Actinobacteria	GJM	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
TLS2_k127_3207878_8	266117.Rxyl_0052	1.659e-29	135.0	COG3429@1|root,COG3429@2|Bacteria,2HYJH@201174|Actinobacteria,4CPZH@84995|Rubrobacteria	84995|Rubrobacteria	G	Glucose-6-phosphate dehydrogenase subunit	-	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
TLS2_k127_3207878_2	1382306.JNIM01000001_gene767	2.331e-186	595.0	COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TLS2_k127_3207878_5	1128421.JAGA01000003_gene3430	1.568e-106	358.0	COG1023@1|root,COG1023@2|Bacteria,2NP1I@2323|unclassified Bacteria	2|Bacteria	G	6-phosphogluconate dehydrogenase, C-terminal domain	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2620,iNJ661.Rv1122	6PGD,NAD_binding_2
TLS2_k127_3207878_4	426117.M446_6706	5.161e-114	382.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,1JSET@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI,TAL_FSA
TLS2_k127_3207878_3	994479.GL877881_gene6459	8.459e-142	461.0	COG0176@1|root,COG0176@2|Bacteria,2GMF9@201174|Actinobacteria,4E8KG@85010|Pseudonocardiales	201174|Actinobacteria	G	Transaldolase/Fructose-6-phosphate aldolase	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TLS2_k127_3207878_6	1123242.JH636434_gene3809	1.331e-51	188.0	COG0698@1|root,COG0698@2|Bacteria,2IZSB@203682|Planctomycetes	203682|Planctomycetes	G	Ribose/Galactose Isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
TLS2_k127_3207878_0	405948.SACE_3326	4.184e-269	841.0	COG0021@1|root,COG0021@2|Bacteria,2I36F@201174|Actinobacteria,4DZ6K@85010|Pseudonocardiales	201174|Actinobacteria	G	Belongs to the transketolase family	tkt3	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TLS2_k127_3207878_1	469383.Cwoe_4548	3.241e-203	653.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria,4CPKI@84995|Rubrobacteria	84995|Rubrobacteria	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
TLS2_k127_3207878_7	405948.SACE_3882	4.789e-51	196.0	COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4E0Z4@85010|Pseudonocardiales	201174|Actinobacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS2_k127_3228628_4	1429046.RR21198_5082	5.278e-64	233.0	COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria,4FV28@85025|Nocardiaceae	201174|Actinobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
TLS2_k127_3228628_2	1146883.BLASA_0968	2.466e-90	319.0	COG0614@1|root,COG0614@2|Bacteria,2I2MI@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	yvrC	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS2_k127_3228628_6	634956.Geoth_0235	6.062e-10	72.0	COG5652@1|root,COG5652@2|Bacteria,1TU2J@1239|Firmicutes,4HQ9P@91061|Bacilli,1WGH9@129337|Geobacillus	91061|Bacilli	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
TLS2_k127_3228628_5	330214.NIDE4014	1.027e-48	189.0	2EUIU@1|root,33N0V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3228628_1	1114959.SZMC14600_19724	6.664e-155	501.0	COG0168@1|root,COG0168@2|Bacteria,2GKKS@201174|Actinobacteria,4E16U@85010|Pseudonocardiales	201174|Actinobacteria	P	Trk-type K transport	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS2_k127_3228628_3	570268.ANBB01000062_gene795	1.2e-70	246.0	COG0569@1|root,COG0569@2|Bacteria,2IA09@201174|Actinobacteria,4EIJX@85012|Streptosporangiales	201174|Actinobacteria	P	TrkA-C domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS2_k127_3228628_0	1205753.A989_05447	1.625e-177	566.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1X3IX@135614|Xanthomonadales	135614|Xanthomonadales	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS2_k127_3230574_6	58123.JOFJ01000009_gene951	5.427e-08	66.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,4EFTZ@85012|Streptosporangiales	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_3230574_4	479434.Sthe_3353	5.942e-38	155.0	COG1295@1|root,COG1295@2|Bacteria,2GARF@200795|Chloroflexi,27Z8N@189775|Thermomicrobia	189775|Thermomicrobia	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_3230574_5	446470.Snas_6443	1.271e-34	139.0	2D19V@1|root,334ZZ@2|Bacteria,2I39B@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3230574_3	204669.Acid345_1504	7.473e-101	347.0	COG2195@1|root,COG2195@2|Bacteria,3Y6CZ@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase dimerisation domain	-	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_3230574_2	1151122.AQYD01000007_gene1190	1.433e-115	388.0	COG2704@1|root,COG2704@2|Bacteria,2GKYB@201174|Actinobacteria,4FM9K@85023|Microbacteriaceae	201174|Actinobacteria	S	Anaerobic c4-dicarboxylate membrane transporter	dcuB	-	-	ko:K07792	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.13.1	-	-	DcuA_DcuB
TLS2_k127_3230574_1	1283299.AUKG01000001_gene3510	2.816e-165	531.0	COG0531@1|root,COG0531@2|Bacteria,2IDWU@201174|Actinobacteria	201174|Actinobacteria	E	Amino acid permease	potE	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
TLS2_k127_3230574_0	1283299.AUKG01000001_gene1412	1.312e-209	666.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
TLS2_k127_3247913_4	1133850.SHJG_8631	2.623e-32	134.0	COG0665@1|root,COG0665@2|Bacteria,2GNAE@201174|Actinobacteria	201174|Actinobacteria	E	PFAM FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS2_k127_3247913_3	204669.Acid345_2480	2.296e-40	162.0	COG0662@1|root,COG0662@2|Bacteria,3Y8AX@57723|Acidobacteria	57723|Acidobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3247913_1	35754.JNYJ01000056_gene9890	2.261e-51	190.0	COG0824@1|root,COG0824@2|Bacteria,2IMQK@201174|Actinobacteria,4DDPF@85008|Micromonosporales	201174|Actinobacteria	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3247913_5	644282.Deba_1008	1.104e-31	141.0	COG0438@1|root,COG5010@1|root,COG0438@2|Bacteria,COG5010@2|Bacteria,1PZAF@1224|Proteobacteria,435UK@68525|delta/epsilon subdivisions,2WWWY@28221|Deltaproteobacteria	2|Bacteria	M	Glycosyltransferase Family 4	-	-	2.7.11.1	ko:K14949	ko05152,map05152	-	-	-	ko00000,ko00001,ko01000,ko01001	-	-	-	DUF3868,Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,TPR_8
TLS2_k127_3247913_2	368407.Memar_1131	1.638e-46	172.0	COG3832@1|root,arCOG05261@2157|Archaea	2157|Archaea	H	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_3247913_0	396588.Tgr7_1784	2.707e-159	529.0	COG1112@1|root,COG2251@1|root,COG1112@2|Bacteria,COG2251@2|Bacteria,1MWW9@1224|Proteobacteria,1RZXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,AAA_30,PDDEXK_1,RNase_H_2
TLS2_k127_3259073_4	999549.KI421514_gene35	7.921e-08	57.0	COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2TQN7@28211|Alphaproteobacteria,2807R@191028|Leisingera	28211|Alphaproteobacteria	O	OsmC-like protein	MA20_16590	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4,OsmC
TLS2_k127_3259073_0	68170.KL590535_gene3741	9.783e-181	576.0	COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria,4E527@85010|Pseudonocardiales	201174|Actinobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DsrC,Pyr_redox_2
TLS2_k127_3259073_3	1214101.BN159_0270	5.03e-36	156.0	COG2920@1|root,COG2920@2|Bacteria,2IQB2@201174|Actinobacteria	201174|Actinobacteria	P	PFAM DsrC family protein	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
TLS2_k127_3259073_1	880073.Calab_2457	2.952e-65	230.0	COG2210@1|root,COG2210@2|Bacteria	2|Bacteria	P	Belongs to the sulfur carrier protein TusA family	perX	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
TLS2_k127_3259073_2	1172179.AUKV01000003_gene7177	8.043e-45	177.0	COG0308@1|root,COG0308@2|Bacteria,2GJWF@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
TLS2_k127_3259459_1	1089553.Tph_c27020	3.914e-148	477.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,42F68@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TLS2_k127_3259459_15	1283299.AUKG01000002_gene3863	4.252e-26	119.0	COG0009@1|root,COG0009@2|Bacteria,2HPE4@201174|Actinobacteria,4CQS7@84995|Rubrobacteria	84995|Rubrobacteria	J	Telomere recombination	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
TLS2_k127_3259459_4	558169.AGAV01000005_gene2442	1.511e-85	307.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,4H9WY@91061|Bacilli	91061|Bacilli	E	abc transporter atp-binding protein	-	-	3.6.3.21	ko:K02028,ko:K10038	ko02010,map02010	M00227,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.2	-	-	ABC_tran
TLS2_k127_3259459_11	42256.RradSPS_2523	8.92e-50	192.0	COG0765@1|root,COG0765@2|Bacteria,2GJJ9@201174|Actinobacteria,4CU2C@84995|Rubrobacteria	84995|Rubrobacteria	P	Amino acid ABC transporter, permease protein, 3-TM	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
TLS2_k127_3259459_12	1121019.AUMN01000001_gene511	2.774e-48	184.0	COG0834@1|root,COG0834@2|Bacteria,2GJQW@201174|Actinobacteria	201174|Actinobacteria	ET	Belongs to the bacterial solute-binding protein 3 family	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
TLS2_k127_3259459_13	1430440.MGMSRv2_3746	8.818e-46	187.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2TZFK@28211|Alphaproteobacteria,2JQMD@204441|Rhodospirillales	204441|Rhodospirillales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_25,Methyltransf_31
TLS2_k127_3259459_2	266117.Rxyl_1652	2.867e-110	366.0	COG0216@1|root,COG0216@2|Bacteria,2GJWG@201174|Actinobacteria,4CP8A@84995|Rubrobacteria	84995|Rubrobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS2_k127_3259459_6	1380390.JIAT01000009_gene371	1.439e-80	282.0	COG3872@1|root,COG3872@2|Bacteria,2IIWY@201174|Actinobacteria,4CPJY@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function (DUF1385)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
TLS2_k127_3259459_14	525909.Afer_1810	3.962e-28	117.0	COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4CP0K@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
TLS2_k127_3259459_9	1380356.JNIK01000011_gene1608	2.233e-60	224.0	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria,4ES0N@85013|Frankiales	201174|Actinobacteria	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
TLS2_k127_3259459_0	469383.Cwoe_4638	4.779e-176	568.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,2HQ59@201174|Actinobacteria,4CRNF@84995|Rubrobacteria	84995|Rubrobacteria	C	Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2
TLS2_k127_3259459_7	469383.Cwoe_4639	1.557e-75	271.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,4CPAU@84995|Rubrobacteria	84995|Rubrobacteria	C	Electron transfer flavoprotein domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TLS2_k127_3259459_8	469383.Cwoe_4640	2.479e-69	244.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,4CPQ9@84995|Rubrobacteria	84995|Rubrobacteria	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
TLS2_k127_3259459_16	1229780.BN381_80183	8.212e-22	110.0	COG0739@1|root,COG0739@2|Bacteria,2HFQA@201174|Actinobacteria,3UWZQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_3259459_10	1380390.JIAT01000009_gene1555	2.103e-55	204.0	COG0352@1|root,COG0352@2|Bacteria,2GKCN@201174|Actinobacteria,4CQ70@84995|Rubrobacteria	84995|Rubrobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	-	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TLS2_k127_3259459_17	1479238.JQMZ01000001_gene1760	0.0001151	53.0	COG2022@1|root,COG2022@2|Bacteria,1QYPA@1224|Proteobacteria,2TXU5@28211|Alphaproteobacteria,440TJ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
TLS2_k127_3259459_3	243230.DR_A0172	5.801e-96	321.0	COG2022@1|root,COG2022@2|Bacteria,1WJ7M@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
TLS2_k127_3259459_5	479434.Sthe_0823	9.16e-85	289.0	COG1024@1|root,COG1024@2|Bacteria,2G5JW@200795|Chloroflexi,27XKS@189775|Thermomicrobia	189775|Thermomicrobia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS2_k127_3264176_9	1353531.AZNX01000012_gene3816	2.728e-77	273.0	COG0625@1|root,COG0625@2|Bacteria,1R9IZ@1224|Proteobacteria,2TRH4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
TLS2_k127_3264176_7	1380390.JIAT01000011_gene2617	6.396e-92	309.0	COG0346@1|root,COG0346@2|Bacteria,2HQTW@201174|Actinobacteria,4CSJT@84995|Rubrobacteria	84995|Rubrobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_3264176_2	794846.AJQU01000056_gene4234	2.722e-183	584.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2TRVF@28211|Alphaproteobacteria,4BAUP@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
TLS2_k127_3264176_8	1057002.KB905370_gene3958	1.967e-80	275.0	COG0372@1|root,COG0372@2|Bacteria,1MUII@1224|Proteobacteria,2TSDI@28211|Alphaproteobacteria,4BD58@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS2_k127_3264176_16	136273.GY22_13955	4.674e-23	109.0	COG1266@1|root,COG1266@2|Bacteria,2HVFD@201174|Actinobacteria,1WBSF@1268|Micrococcaceae	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS2_k127_3264176_12	1137271.AZUM01000001_gene913	5.875e-55	198.0	COG1522@1|root,COG1522@2|Bacteria,2IG2K@201174|Actinobacteria,4E43E@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
TLS2_k127_3264176_3	469383.Cwoe_4383	3.393e-180	600.0	COG2040@1|root,COG2264@1|root,COG2040@2|Bacteria,COG2264@2|Bacteria,2HQK7@201174|Actinobacteria,4CS5N@84995|Rubrobacteria	84995|Rubrobacteria	EJ	Homocysteine S-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PrmA,S-methyl_trans
TLS2_k127_3264176_4	1123240.ATVO01000003_gene164	3.117e-146	470.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,2K3CA@204457|Sphingomonadales	204457|Sphingomonadales	E	Cobalamin-independent synthase, Catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
TLS2_k127_3264176_10	266117.Rxyl_1793	2.322e-65	231.0	COG2085@1|root,COG2085@2|Bacteria,2I8W4@201174|Actinobacteria,4CQDF@84995|Rubrobacteria	84995|Rubrobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
TLS2_k127_3264176_15	309801.trd_A0568	1.994e-27	120.0	COG2068@1|root,COG2068@2|Bacteria	2|Bacteria	NU	MobA-Related Protein	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	HD,NTP_transf_3
TLS2_k127_3264176_6	266117.Rxyl_0113	8.444e-95	347.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4CSQX@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM molybdopterin dehydrogenase, FAD-binding	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS2_k127_3264176_0	266117.Rxyl_0112	4.644e-301	942.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4CS94@84995|Rubrobacteria	84995|Rubrobacteria	C	xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS2_k127_3264176_11	644966.Tmar_1491	4.9e-63	238.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia,3WDUM@538999|Clostridiales incertae sedis	186801|Clostridia	C	COGs COG2080 Aerobic-type carbon monoxide dehydrogenase small subunit CoxS CutS homologs	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS2_k127_3264176_14	469383.Cwoe_4106	7.61e-37	158.0	COG3427@1|root,COG3427@2|Bacteria,2GKTQ@201174|Actinobacteria,4CT27@84995|Rubrobacteria	84995|Rubrobacteria	S	carbon monoxide dehydrogenase subunit G	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
TLS2_k127_3264176_5	1137268.AZXF01000016_gene1014	1.691e-95	336.0	COG1975@1|root,COG1975@2|Bacteria,2GIZS@201174|Actinobacteria,4EIDG@85012|Streptosporangiales	201174|Actinobacteria	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS2_k127_3264176_13	1382306.JNIM01000001_gene2451	8.569e-51	206.0	COG1975@1|root,COG3350@1|root,COG1975@2|Bacteria,COG3350@2|Bacteria,2G88Z@200795|Chloroflexi	200795|Chloroflexi	O	YHS domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
TLS2_k127_3264176_1	502025.Hoch_2000	2.253e-294	910.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
TLS2_k127_3294951_15	760568.Desku_2747	5.515e-54	201.0	COG2301@1|root,COG2301@2|Bacteria,1TPDY@1239|Firmicutes,24AIH@186801|Clostridia,260C4@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS2_k127_3294951_13	1101188.KI912156_gene4127	1.016e-68	238.0	COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,1W93S@1268|Micrococcaceae	201174|Actinobacteria	I	MaoC like domain	-	-	4.2.1.56	ko:K18290	ko00660,map00660	-	R02491	RC00730	ko00000,ko00001,ko01000	-	-	-	MaoC_dehydratas
TLS2_k127_3294951_5	675635.Psed_0101	2.348e-110	374.0	COG2079@1|root,COG2079@2|Bacteria,2GKUR@201174|Actinobacteria,4E0R9@85010|Pseudonocardiales	201174|Actinobacteria	S	protein involved in propionate catabolism	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
TLS2_k127_3294951_2	994479.GL877879_gene5063	1.103e-174	578.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4DXA8@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3294951_1	469383.Cwoe_5073	4.49e-191	602.0	COG1960@1|root,COG1960@2|Bacteria,2GNFB@201174|Actinobacteria,4CPM4@84995|Rubrobacteria	84995|Rubrobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3294951_6	2074.JNYD01000016_gene4205	7.043e-97	326.0	COG2141@1|root,COG2141@2|Bacteria,2GMUP@201174|Actinobacteria,4EBZH@85010|Pseudonocardiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_3294951_14	246196.MSMEI_2395	1.526e-57	213.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,235A3@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
TLS2_k127_3294951_4	266117.Rxyl_2744	7.396e-113	375.0	COG0523@1|root,COG0523@2|Bacteria,2GKDR@201174|Actinobacteria,4CQ83@84995|Rubrobacteria	84995|Rubrobacteria	S	Cobalamin synthesis protein cobW C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
TLS2_k127_3294951_3	1380763.BG53_13170	1.064e-168	541.0	COG0726@1|root,COG0726@2|Bacteria,1VA2Q@1239|Firmicutes,4HEX3@91061|Bacilli,2730V@186822|Paenibacillaceae	91061|Bacilli	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
TLS2_k127_3294951_17	331869.BAL199_03499	5.282e-05	56.0	COG0697@1|root,COG0697@2|Bacteria,1R6SK@1224|Proteobacteria,2U4IR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_3294951_8	266117.Rxyl_2747	2.074e-93	332.0	COG1335@1|root,COG1335@2|Bacteria	2|Bacteria	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	-	-	3.5.1.107	ko:K13995	ko00760,ko01120,map00760,map01120	M00622	R03540	RC00950	ko00000,ko00001,ko00002,ko01000	-	-	-	Isochorismatase
TLS2_k127_3294951_0	266117.Rxyl_2746	6.582e-225	722.0	COG0044@1|root,COG0044@2|Bacteria,2GK4A@201174|Actinobacteria,4CPS2@84995|Rubrobacteria	84995|Rubrobacteria	F	Amidohydrolase family	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
TLS2_k127_3294951_11	1121479.AUBS01000036_gene2928	1.08e-76	269.0	COG0252@1|root,COG0252@2|Bacteria,1MWIR@1224|Proteobacteria,2U1B3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EJ	COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
TLS2_k127_3294951_10	479434.Sthe_2991	2.451e-77	268.0	COG1177@1|root,COG1177@2|Bacteria	2|Bacteria	P	DNA import into cell involved in transformation	MA20_32205	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
TLS2_k127_3294951_12	479434.Sthe_2992	3.629e-73	261.0	COG1176@1|root,COG1176@2|Bacteria,2G6E0@200795|Chloroflexi,27XNS@189775|Thermomicrobia	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
TLS2_k127_3294951_7	479434.Sthe_2993	1.504e-96	328.0	COG3842@1|root,COG3842@2|Bacteria,2G62V@200795|Chloroflexi	2|Bacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K02052,ko:K11072	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11,3.A.1.11.1	-	-	ABC_tran,TOBE_2
TLS2_k127_3294951_9	479434.Sthe_2994	9.725e-83	284.0	COG0687@1|root,COG0687@2|Bacteria	2|Bacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_6,SBP_bac_8
TLS2_k127_3331809_1	357808.RoseRS_0717	6.548e-94	316.0	COG2897@1|root,COG2897@2|Bacteria,2G5XI@200795|Chloroflexi,374RX@32061|Chloroflexia	32061|Chloroflexia	P	PFAM Rhodanese domain protein	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS2_k127_3331809_2	1298880.AUEV01000002_gene1752	3.568e-20	104.0	COG1396@1|root,COG1396@2|Bacteria,2GNQ9@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31,TPR_12,TPR_16,TPR_8
TLS2_k127_3331809_3	644966.Tmar_1853	5.043e-16	92.0	COG1309@1|root,COG1309@2|Bacteria,1V4AJ@1239|Firmicutes	1239|Firmicutes	K	Transcriptional regulator	betI1	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_3331809_0	469383.Cwoe_4177	4.891e-111	373.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_3365449_1	935845.JADQ01000032_gene1332	6.616e-36	148.0	COG1216@1|root,COG1216@2|Bacteria,1TS11@1239|Firmicutes,4HDKY@91061|Bacilli,26U9S@186822|Paenibacillaceae	91061|Bacilli	S	Glycosyl transferase family 2	ycbB	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
TLS2_k127_3365449_0	710696.Intca_0183	4.841e-170	543.0	COG4222@1|root,COG4222@2|Bacteria,2GJN8@201174|Actinobacteria,4FF9Q@85021|Intrasporangiaceae	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_3368828_7	1297742.A176_00262	1.319e-54	218.0	COG1470@1|root,COG2885@1|root,COG4719@1|root,COG1470@2|Bacteria,COG2885@2|Bacteria,COG4719@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF11,OmpA,Phenol_MetA_deg,TSP_3
TLS2_k127_3368828_9	1283299.AUKG01000001_gene2585	1.61e-21	111.0	COG3055@1|root,COG3055@2|Bacteria,2HPP7@201174|Actinobacteria,4CR1T@84995|Rubrobacteria	84995|Rubrobacteria	S	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3368828_8	1320556.AVBP01000020_gene226	8.566e-39	156.0	COG2519@1|root,COG2519@2|Bacteria,1Q81I@1224|Proteobacteria,2UW4E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS2_k127_3368828_4	1380390.JIAT01000016_gene5621	2.707e-143	460.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4CPI2@84995|Rubrobacteria	84995|Rubrobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
TLS2_k127_3368828_5	1380390.JIAT01000016_gene5622	2.85e-116	382.0	COG0842@1|root,COG0842@2|Bacteria,2GMXR@201174|Actinobacteria,4CPJK@84995|Rubrobacteria	84995|Rubrobacteria	V	ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
TLS2_k127_3368828_3	926560.KE387025_gene3943	4.362e-164	533.0	COG0058@1|root,COG0058@2|Bacteria,1WIR5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Alpha-glucan phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
TLS2_k127_3368828_6	395495.Lcho_2149	7.965e-75	256.0	COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,2VQ8C@28216|Betaproteobacteria,1KKPN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	porC	-	1.2.1.58,1.2.7.1	ko:K00172,ko:K18357	ko00010,ko00020,ko00360,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00360,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R02450,R08034	RC00004,RC00250,RC02742,RC02833,RC02860	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
TLS2_k127_3368828_1	345341.KUTG_00477	1.901e-191	607.0	COG0674@1|root,COG0674@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
TLS2_k127_3368828_2	345341.KUTG_00476	6.753e-174	559.0	COG1013@1|root,COG1013@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	porB	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
TLS2_k127_3368828_0	946483.Cenrod_0414	1.713e-260	829.0	COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,4AD4V@80864|Comamonadaceae	28216|Betaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3
TLS2_k127_3368828_10	1121946.AUAX01000007_gene2997	6.925e-12	66.0	COG2513@1|root,COG2513@2|Bacteria,2GMQ4@201174|Actinobacteria,4DEP9@85008|Micromonosporales	201174|Actinobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
TLS2_k127_3391247_3	469383.Cwoe_2902	1.229e-77	263.0	COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria,4CPVR@84995|Rubrobacteria	84995|Rubrobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,DUF836,Put_DNA-bind_N
TLS2_k127_3391247_6	1378168.N510_00620	1.004e-31	136.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes	1239|Firmicutes	K	Belongs to the sigma-70 factor family. ECF subfamily	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_3391247_4	1283299.AUKG01000001_gene3214	3.877e-59	222.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,2H432@201174|Actinobacteria,4CR80@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_3391247_5	1173027.Mic7113_1368	7.512e-52	211.0	COG2319@1|root,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1H7HR@1150|Oscillatoriales	1117|Cyanobacteria	S	WD domain, G-beta repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,SpoIIE,TIR_2,WD40
TLS2_k127_3391247_2	469383.Cwoe_2903	3.218e-103	349.0	COG2170@1|root,COG2170@2|Bacteria,2H5B4@201174|Actinobacteria,4CQ42@84995|Rubrobacteria	84995|Rubrobacteria	S	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
TLS2_k127_3391247_8	1283299.AUKG01000004_gene1090	1.157e-12	74.0	2AUTP@1|root,31KGR@2|Bacteria,2HPBN@201174|Actinobacteria,4CQQ3@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3391247_7	1265490.JHVY01000034_gene955	1.933e-20	101.0	COG0596@1|root,COG0596@2|Bacteria,1QTWQ@1224|Proteobacteria,1T1JQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_3391247_1	509191.AEDB02000109_gene5098	5.508e-104	346.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,3WNHF@541000|Ruminococcaceae	186801|Clostridia	F	Phosphorylase superfamily	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS2_k127_3391247_0	1123377.AUIV01000012_gene702	4.774e-195	619.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1X3IX@135614|Xanthomonadales	135614|Xanthomonadales	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS2_k127_3402199_1	1380390.JIAT01000010_gene4144	1.448e-46	184.0	COG1408@1|root,COG1408@2|Bacteria,2HQ8Y@201174|Actinobacteria,4CRSV@84995|Rubrobacteria	84995|Rubrobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
TLS2_k127_3402199_0	479434.Sthe_2123	2.225e-140	463.0	COG2267@1|root,COG2267@2|Bacteria,2G75K@200795|Chloroflexi	200795|Chloroflexi	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TLS2_k127_3530742_0	1089544.KB912942_gene1881	8.855e-178	582.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4DXVG@85010|Pseudonocardiales	201174|Actinobacteria	G	hydrolase, family 65, central catalytic	kojP	-	2.4.1.230	ko:K10231	-	-	-	-	ko00000,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
TLS2_k127_3530742_5	1123368.AUIS01000028_gene1323	8.06e-15	88.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_3530742_3	390989.JOEG01000005_gene2081	5.84e-41	160.0	2CA7I@1|root,30E5G@2|Bacteria,2IJ78@201174|Actinobacteria,4DGHF@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3530742_1	1146883.BLASA_4593	1.307e-60	223.0	COG0392@1|root,COG0392@2|Bacteria,2ICMJ@201174|Actinobacteria,4ETKK@85013|Frankiales	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
TLS2_k127_3530742_4	1384056.N787_03590	7.987e-39	161.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,1X48D@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
TLS2_k127_3530742_2	469383.Cwoe_2412	5.241e-48	179.0	28K8S@1|root,2Z9WH@2|Bacteria,2GW35@201174|Actinobacteria,4CS76@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3688357_3	1280688.AUJB01000009_gene1652	1.031e-25	123.0	COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,247Q6@186801|Clostridia,3NGPZ@46205|Pseudobutyrivibrio	186801|Clostridia	S	PSP1 C-terminal conserved region	yaaT	-	-	-	-	-	-	-	-	-	-	-	PSP1
TLS2_k127_3688357_2	479434.Sthe_0659	5.081e-29	131.0	COG2812@1|root,COG2812@2|Bacteria,2G6K3@200795|Chloroflexi,27Y5T@189775|Thermomicrobia	189775|Thermomicrobia	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
TLS2_k127_3688357_1	649743.HMPREF0972_00110	3.373e-55	205.0	COG0125@1|root,COG0125@2|Bacteria,2GNTI@201174|Actinobacteria,4D3KI@85005|Actinomycetales	201174|Actinobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_1,MFS_3,Thymidylate_kin
TLS2_k127_3688357_0	469383.Cwoe_5315	7.878e-91	312.0	COG0451@1|root,COG0451@2|Bacteria,2I2UT@201174|Actinobacteria,4CRA0@84995|Rubrobacteria	84995|Rubrobacteria	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_3746968_1	404589.Anae109_0783	7.908e-60	226.0	COG0122@1|root,COG0122@2|Bacteria,1P0FP@1224|Proteobacteria	1224|Proteobacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	-	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TLS2_k127_3746968_4	869210.Marky_0753	5.572e-33	141.0	COG1430@1|root,COG1430@2|Bacteria,1WJRZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
TLS2_k127_3746968_5	469383.Cwoe_3685	5.158e-32	141.0	COG1585@1|root,COG1585@2|Bacteria,2HPFR@201174|Actinobacteria,4CQU5@84995|Rubrobacteria	84995|Rubrobacteria	OU	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
TLS2_k127_3746968_0	1048339.KB913029_gene4293	3.761e-131	432.0	COG0330@1|root,COG0330@2|Bacteria,2GJ1U@201174|Actinobacteria,4ERTI@85013|Frankiales	201174|Actinobacteria	O	PFAM Band 7 protein	hflK	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_3746968_3	1273125.Rrhod_4250	3.209e-47	184.0	COG0350@1|root,COG0350@2|Bacteria,2GKA9@201174|Actinobacteria,4G0II@85025|Nocardiaceae	201174|Actinobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
TLS2_k127_3746968_6	1122138.AQUZ01000036_gene5440	4.706e-11	71.0	COG1595@1|root,COG1595@2|Bacteria,2II47@201174|Actinobacteria,4DRDP@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_3746968_2	469383.Cwoe_1085	1.405e-55	207.0	COG0524@1|root,COG0524@2|Bacteria,2H514@201174|Actinobacteria,4CT2F@84995|Rubrobacteria	84995|Rubrobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS2_k127_3768213_1	670487.Ocepr_1720	7.37e-111	374.0	COG3033@1|root,COG3033@2|Bacteria,1WM62@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_3768213_6	469383.Cwoe_5328	3.96e-67	237.0	COG3132@1|root,COG3132@2|Bacteria,2I5BV@201174|Actinobacteria,4CSYU@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function, DUF480	-	-	-	-	-	-	-	-	-	-	-	-	DUF480
TLS2_k127_3768213_0	266117.Rxyl_1489	1.203e-146	472.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria,4CP7W@84995|Rubrobacteria	84995|Rubrobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS2_k127_3768213_10	1380346.JNIH01000005_gene3246	6.15e-08	64.0	COG1589@1|root,COG1589@2|Bacteria,2H4A4@201174|Actinobacteria	201174|Actinobacteria	D	cell division protein FtsQ	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
TLS2_k127_3768213_8	290397.Adeh_3773	1.743e-53	205.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,42P86@68525|delta/epsilon subdivisions,2WN8T@28221|Deltaproteobacteria,2Z308@29|Myxococcales	28221|Deltaproteobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
TLS2_k127_3768213_5	590998.Celf_1617	2.551e-73	273.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4F0NZ@85016|Cellulomonadaceae	201174|Actinobacteria	M	Mur ligase family, catalytic domain	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_3768213_3	469383.Cwoe_3770	7.725e-97	329.0	COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria,4CPNI@84995|Rubrobacteria	84995|Rubrobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
TLS2_k127_3768213_4	264732.Moth_0842	3.923e-77	291.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,42EPV@68295|Thermoanaerobacterales	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
TLS2_k127_3768213_2	469383.Cwoe_3772	3.143e-104	358.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4CQ2K@84995|Rubrobacteria	84995|Rubrobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
TLS2_k127_3768213_7	479434.Sthe_2277	3.879e-54	203.0	COG0639@1|root,COG0639@2|Bacteria,2G8I3@200795|Chloroflexi	200795|Chloroflexi	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
TLS2_k127_3768213_9	929712.KI912613_gene3338	3.471e-17	82.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,4CPF5@84995|Rubrobacteria	84995|Rubrobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
TLS2_k127_3768746_6	246194.CHY_2223	4.191e-52	190.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,42F3U@68295|Thermoanaerobacterales	186801|Clostridia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
TLS2_k127_3768746_1	469383.Cwoe_3186	7.16e-154	506.0	COG0608@1|root,COG0608@2|Bacteria,2IK2U@201174|Actinobacteria,4CPI9@84995|Rubrobacteria	84995|Rubrobacteria	L	DHH family	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TLS2_k127_3768746_9	469383.Cwoe_3792	9.822e-33	135.0	2AW02@1|root,31MUH@2|Bacteria,2HQH7@201174|Actinobacteria,4CS2A@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3768746_0	710696.Intca_0881	0.0	1170.0	COG2866@1|root,COG4412@1|root,COG2866@2|Bacteria,COG4412@2|Bacteria,2GN49@201174|Actinobacteria,4FIMN@85021|Intrasporangiaceae	201174|Actinobacteria	M	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14,Peptidase_M6
TLS2_k127_3768746_3	644966.Tmar_0849	7.892e-127	421.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,3WCER@538999|Clostridiales incertae sedis	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
TLS2_k127_3768746_7	292459.STH1160	1.163e-38	160.0	COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
TLS2_k127_3768746_8	1122939.ATUD01000005_gene2683	1.3e-38	149.0	COG0817@1|root,COG0817@2|Bacteria,2GJI5@201174|Actinobacteria,4CQCR@84995|Rubrobacteria	84995|Rubrobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
TLS2_k127_3768746_11	1122223.KB890701_gene2173	4.521e-14	86.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	ycf48	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR
TLS2_k127_3768746_12	1122223.KB890701_gene2173	3.779e-13	80.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	ycf48	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR
TLS2_k127_3768746_4	266117.Rxyl_1318	4.94e-84	285.0	COG0217@1|root,COG0217@2|Bacteria,2GJ4G@201174|Actinobacteria,4CPAM@84995|Rubrobacteria	84995|Rubrobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TLS2_k127_3768746_5	222534.KB893671_gene3240	9.257e-64	224.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4ESCW@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
TLS2_k127_3768746_2	266117.Rxyl_1316	6.208e-131	424.0	COG0214@1|root,COG0214@2|Bacteria,2GK1T@201174|Actinobacteria,4CPM6@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
TLS2_k127_3768746_10	1298880.AUEV01000001_gene5684	6.358e-20	90.0	COG2818@1|root,COG2818@2|Bacteria,2IFH0@201174|Actinobacteria	201174|Actinobacteria	L	Glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
TLS2_k127_37719_2	469383.Cwoe_3232	2.106e-159	526.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4CPRU@84995|Rubrobacteria	84995|Rubrobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TLS2_k127_37719_7	1042156.CXIVA_23320	4.325e-32	130.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,36KHC@31979|Clostridiaceae	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
TLS2_k127_37719_3	33876.JNXY01000022_gene4581	6.538e-100	343.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4D95N@85008|Micromonosporales	201174|Actinobacteria	E	Gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_37719_5	42256.RradSPS_1421	5.33e-61	228.0	COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4CPIB@84995|Rubrobacteria	84995|Rubrobacteria	H	Belongs to the ribF family	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
TLS2_k127_37719_6	469383.Cwoe_3225	2.067e-47	184.0	COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4CPY4@84995|Rubrobacteria	84995|Rubrobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_N
TLS2_k127_37719_4	469383.Cwoe_3224	8.264e-88	301.0	COG0618@1|root,COG0618@2|Bacteria,2GN9Z@201174|Actinobacteria,4CPFM@84995|Rubrobacteria	84995|Rubrobacteria	S	DHH family	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TLS2_k127_37719_8	469383.Cwoe_3223	3.144e-26	126.0	COG0858@1|root,COG0858@2|Bacteria,2HPFC@201174|Actinobacteria,4CQTS@84995|Rubrobacteria	84995|Rubrobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
TLS2_k127_37719_11	469383.Cwoe_3222	1.42e-17	85.0	COG1550@1|root,COG1550@2|Bacteria	2|Bacteria	H	Protein conserved in bacteria	ylxP	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
TLS2_k127_37719_0	1122939.ATUD01000005_gene2718	3.736e-203	651.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4CP7T@84995|Rubrobacteria	84995|Rubrobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
TLS2_k127_37719_12	706587.Desti_3723	3.145e-09	70.0	COG2740@1|root,COG2740@2|Bacteria	2|Bacteria	K	Nucleic-acid-binding protein implicated in transcription termination	ylxR	-	-	ko:K02600,ko:K07742	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	DUF448
TLS2_k127_37719_1	469383.Cwoe_3219	6.447e-161	529.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4CPEF@84995|Rubrobacteria	84995|Rubrobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
TLS2_k127_37719_9	1380390.JIAT01000010_gene4843	2.333e-24	116.0	COG0779@1|root,COG0779@2|Bacteria,2HPFT@201174|Actinobacteria,4CQU9@84995|Rubrobacteria	84995|Rubrobacteria	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
TLS2_k127_37719_10	665952.HMPREF1015_00389	2.698e-19	89.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,4HINN@91061|Bacilli,1ZG82@1386|Bacillus	91061|Bacilli	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
TLS2_k127_37719_13	1170318.PALO_09300	6.513e-07	60.0	COG1961@1|root,COG1961@2|Bacteria,2GMAS@201174|Actinobacteria,4DWNV@85009|Propionibacteriales	201174|Actinobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS2_k127_3778932_1	446468.Ndas_3395	1.347e-16	93.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4EI3T@85012|Streptosporangiales	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_3778932_2	1122138.AQUZ01000019_gene8186	4.177e-07	63.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4DNJC@85009|Propionibacteriales	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_3778932_0	543632.JOJL01000033_gene3274	4.568e-121	403.0	COG0312@1|root,COG0312@2|Bacteria,2GJ4E@201174|Actinobacteria,4DBR6@85008|Micromonosporales	201174|Actinobacteria	S	peptidase U62, modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS2_k127_3784895_4	153496.JNAB01000010_gene306	2.573e-34	136.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,2JP8R@204441|Rhodospirillales	204441|Rhodospirillales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_3784895_3	1122939.ATUD01000003_gene3306	1.461e-34	147.0	COG0681@1|root,COG0681@2|Bacteria,2HF4W@201174|Actinobacteria,4CTUY@84995|Rubrobacteria	84995|Rubrobacteria	U	Peptidase S24-like	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
TLS2_k127_3784895_6	1306174.JODP01000003_gene2198	9.258e-11	70.0	COG1523@1|root,COG1523@2|Bacteria,2GS7F@201174|Actinobacteria	2|Bacteria	G	belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	PUD,YSIRK_signal
TLS2_k127_3784895_5	1122939.ATUD01000003_gene3303	9.82e-23	109.0	2DN4G@1|root,32VGH@2|Bacteria,2HRUB@201174|Actinobacteria,4CTXR@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3784895_0	469383.Cwoe_2889	5.863e-95	320.0	COG0413@1|root,COG0413@2|Bacteria,2GJP6@201174|Actinobacteria,4CQ9E@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TLS2_k127_3784895_1	1121430.JMLG01000002_gene1142	1.524e-76	273.0	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia,26011@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
TLS2_k127_3784895_2	1122939.ATUD01000004_gene3697	2.144e-36	144.0	COG5495@1|root,COG5495@2|Bacteria,2HGVM@201174|Actinobacteria,4CT6K@84995|Rubrobacteria	84995|Rubrobacteria	S	Domain of unknown function (DUF2520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520
TLS2_k127_3790622_3	1449353.JQMQ01000005_gene1023	4.266e-13	70.0	COG2850@1|root,COG2850@2|Bacteria,2GMR2@201174|Actinobacteria,2NHVX@228398|Streptacidiphilus	201174|Actinobacteria	S	A domain family that is part of the cupin metalloenzyme superfamily.	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_4
TLS2_k127_3790622_1	882082.SaccyDRAFT_0025	6.598e-45	175.0	COG4759@1|root,COG4759@2|Bacteria,2GRSQ@201174|Actinobacteria,4DYIC@85010|Pseudonocardiales	201174|Actinobacteria	O	Sucrase/ferredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Suc_Fer-like
TLS2_k127_3790622_6	1385521.N803_14755	0.0004335	47.0	2BU6R@1|root,32PFZ@2|Bacteria,2GU0N@201174|Actinobacteria,4FHWE@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3790622_0	316274.Haur_4207	3.061e-179	582.0	COG4770@1|root,COG4770@2|Bacteria,2GBIE@200795|Chloroflexi,3753Q@32061|Chloroflexia	32061|Chloroflexia	I	Carbamoyl-phosphate synthetase large chain domain protein	-	-	6.3.4.14,6.4.1.2,6.4.1.3	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
TLS2_k127_3790622_2	235909.GK1293	4.343e-24	111.0	COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,4HCEX@91061|Bacilli,1WF1K@129337|Geobacillus	91061|Bacilli	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS06365	CDP-OH_P_transf
TLS2_k127_3790622_4	926566.Terro_3410	5.524e-05	55.0	COG0454@1|root,COG0456@2|Bacteria,3Y5KS@57723|Acidobacteria,2JJY0@204432|Acidobacteriia	204432|Acidobacteriia	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TLS2_k127_3790622_5	1380390.JIAT01000016_gene5629	0.0001868	54.0	COG0791@1|root,COG0791@2|Bacteria,2HPJC@201174|Actinobacteria,4CQWT@84995|Rubrobacteria	84995|Rubrobacteria	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
TLS2_k127_3805717_5	253839.SSNG_02607	1.554e-58	209.0	COG1351@1|root,COG1351@2|Bacteria,2HCNJ@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	GO:0000166,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0036094,GO:0040007,GO:0042083,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050797,GO:0070402,GO:0097159,GO:1901265,GO:1901363	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	iNJ661.Rv2754c	Thy1
TLS2_k127_3805717_14	266117.Rxyl_0939	0.0004374	52.0	COG5343@1|root,COG5343@2|Bacteria	2|Bacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA,zf-HC2
TLS2_k127_3805717_10	1380393.JHVP01000003_gene911	1.191e-27	132.0	COG1595@1|root,COG1595@2|Bacteria,2GP9D@201174|Actinobacteria,4ESQB@85013|Frankiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigK	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS2_k127_3805717_9	357808.RoseRS_0542	3.934e-37	150.0	COG1028@1|root,COG1028@2|Bacteria,2G8K5@200795|Chloroflexi,3779V@32061|Chloroflexia	32061|Chloroflexia	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
TLS2_k127_3805717_2	1379698.RBG1_1C00001G0299	9.494e-75	256.0	COG0605@1|root,COG0605@2|Bacteria,2NP62@2323|unclassified Bacteria	2|Bacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	LysM,Sod_Fe_C,Sod_Fe_N
TLS2_k127_3805717_8	1121428.DESHY_60198___1	5.644e-40	155.0	COG0344@1|root,COG0344@2|Bacteria,1VA3J@1239|Firmicutes,24JA2@186801|Clostridia,261ZE@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
TLS2_k127_3805717_1	1283299.AUKG01000001_gene2450	5.062e-96	326.0	COG1469@1|root,COG1469@2|Bacteria,2HPYB@201174|Actinobacteria,4CRDI@84995|Rubrobacteria	84995|Rubrobacteria	S	Type I GTP cyclohydrolase folE2	-	-	-	-	-	-	-	-	-	-	-	-	GCHY-1
TLS2_k127_3805717_12	1121372.AULK01000003_gene192	8.393e-09	67.0	COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,4FKMW@85023|Microbacteriaceae	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_3805717_13	1254432.SCE1572_21325	1.494e-07	61.0	2BD51@1|root,326SN@2|Bacteria,1RM0E@1224|Proteobacteria,43526@68525|delta/epsilon subdivisions,2WZD6@28221|Deltaproteobacteria,2Z1VP@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3805717_3	266117.Rxyl_0884	8.314e-69	239.0	COG0662@1|root,COG0662@2|Bacteria,2I5KR@201174|Actinobacteria,4CTK8@84995|Rubrobacteria	84995|Rubrobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_3805717_4	1463934.JOCF01000073_gene5804	1.542e-61	222.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the FPG family	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_3805717_6	1489678.RDMS_12595	2.287e-53	200.0	COG4448@1|root,COG4448@2|Bacteria,1WIDX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
TLS2_k127_3805717_0	469383.Cwoe_5366	6.588e-157	503.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CPPG@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_3805717_7	1122939.ATUD01000012_gene3199	1.371e-48	179.0	COG0053@1|root,COG0053@2|Bacteria,2GJ8Q@201174|Actinobacteria,4CPB0@84995|Rubrobacteria	84995|Rubrobacteria	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TLS2_k127_3810067_7	913325.N799_03740	2.554e-09	60.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,1X6XJ@135614|Xanthomonadales	135614|Xanthomonadales	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
TLS2_k127_3810067_1	469383.Cwoe_2663	3.825e-170	566.0	COG1530@1|root,COG1530@2|Bacteria,2GMM5@201174|Actinobacteria,4CPSJ@84995|Rubrobacteria	84995|Rubrobacteria	J	Ribonuclease E/G family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
TLS2_k127_3810067_3	1380390.JIAT01000002_gene5999	1.89e-86	301.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4CPV0@84995|Rubrobacteria	84995|Rubrobacteria	D	Belongs to the SEDS family	-	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
TLS2_k127_3810067_2	469383.Cwoe_2661	5.582e-105	365.0	COG0768@1|root,COG0768@2|Bacteria,2GJ61@201174|Actinobacteria,4CPBN@84995|Rubrobacteria	84995|Rubrobacteria	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
TLS2_k127_3810067_6	365528.KB891102_gene4583	3.545e-10	72.0	COG2891@1|root,COG2891@2|Bacteria,2GN0I@201174|Actinobacteria,4EWK3@85013|Frankiales	201174|Actinobacteria	M	rod shape-determining protein MreD	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
TLS2_k127_3810067_5	1380390.JIAT01000002_gene5996	3.542e-37	152.0	COG1792@1|root,COG1792@2|Bacteria,2HP68@201174|Actinobacteria,4CQHY@84995|Rubrobacteria	84995|Rubrobacteria	M	rod shape-determining protein MreC	-	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
TLS2_k127_3810067_0	469383.Cwoe_2658	8.865e-182	573.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4CP7J@84995|Rubrobacteria	84995|Rubrobacteria	D	Cell shape determining protein MreB Mrl	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TLS2_k127_3810067_4	713587.THITH_00350	1.626e-48	182.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,1RPJH@1236|Gammaproteobacteria,1WWU7@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
TLS2_k127_3811135_3	1122138.AQUZ01000019_gene8190	5.245e-58	208.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4DNJC@85009|Propionibacteriales	2|Bacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_3811135_1	1122138.AQUZ01000019_gene8190	2.048e-105	362.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4DNJC@85009|Propionibacteriales	2|Bacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_3811135_0	1232683.ADIMK_3344	5.725e-110	388.0	COG2114@1|root,COG2114@2|Bacteria,1QWNC@1224|Proteobacteria,1S3UK@1236|Gammaproteobacteria,468QZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1,4.6.1.2	ko:K01768,ko:K01769	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
TLS2_k127_3811135_5	1232683.ADIMK_3343	3.085e-32	129.0	COG2346@1|root,COG2346@2|Bacteria	2|Bacteria	O	COG2346, Truncated hemoglobins	glbN	GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008941,GO:0009056,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016491,GO:0016705,GO:0016708,GO:0017144,GO:0019825,GO:0020012,GO:0020037,GO:0030682,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042737,GO:0043207,GO:0044237,GO:0044248,GO:0044270,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046209,GO:0046210,GO:0046906,GO:0048037,GO:0050896,GO:0051213,GO:0051410,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0072593,GO:0075136,GO:0097159,GO:0098754,GO:1901363,GO:1901698,GO:2001057	-	ko:K03406,ko:K06886	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	Bac_globin
TLS2_k127_3811135_4	68170.KL590511_gene2984	5.523e-51	190.0	COG3576@1|root,COG3576@2|Bacteria,2I46F@201174|Actinobacteria,4EDRQ@85010|Pseudonocardiales	201174|Actinobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_3811135_2	469383.Cwoe_1723	2.57e-73	261.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4CRWU@84995|Rubrobacteria	84995|Rubrobacteria	P	ATPase (P-type)	-	-	3.6.3.8	ko:K01537,ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.2,3.A.3.23	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS2_k127_3811190_6	512565.AMIS_48330	1.466e-53	200.0	COG2382@1|root,COG2382@2|Bacteria,2HWND@201174|Actinobacteria,4DJN7@85008|Micromonosporales	201174|Actinobacteria	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase
TLS2_k127_3811190_3	1254432.SCE1572_15220	1.239e-92	320.0	COG2133@1|root,COG2133@2|Bacteria,1PG5V@1224|Proteobacteria,4389W@68525|delta/epsilon subdivisions,2XA3Y@28221|Deltaproteobacteria,2YWB0@29|Myxococcales	28221|Deltaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS2_k127_3811190_4	1380390.JIAT01000014_gene6287	2.83e-63	241.0	COG1807@1|root,COG1807@2|Bacteria,2HJTU@201174|Actinobacteria,4CPVS@84995|Rubrobacteria	84995|Rubrobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3811190_0	266117.Rxyl_1174	1.347e-140	478.0	COG1178@1|root,COG1178@2|Bacteria,2GKPT@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
TLS2_k127_3811190_1	42256.RradSPS_1165	8.85e-105	351.0	COG1840@1|root,COG1840@2|Bacteria	2|Bacteria	P	iron ion homeostasis	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_1,SBP_bac_11,SBP_bac_6,SBP_bac_8
TLS2_k127_3811190_2	266117.Rxyl_1173	6.465e-96	344.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4CRCY@84995|Rubrobacteria	201174|Actinobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
TLS2_k127_3811190_8	1033739.CAEU01000052_gene267	2.827e-37	160.0	COG0860@1|root,COG0860@2|Bacteria,1UY5Q@1239|Firmicutes,4HJKG@91061|Bacilli,26HHN@186818|Planococcaceae	91061|Bacilli	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
TLS2_k127_3811190_12	1449044.JMLE01000004_gene2605	2.276e-08	65.0	COG3832@1|root,COG3832@2|Bacteria,2I51C@201174|Actinobacteria	201174|Actinobacteria	K	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_3811190_11	1216932.CM240_2681	8.317e-17	85.0	COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,24QZQ@186801|Clostridia,36JK5@31979|Clostridiaceae	186801|Clostridia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
TLS2_k127_3811190_5	1380390.JIAT01000009_gene1856	5.363e-57	201.0	COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,4CQAY@84995|Rubrobacteria	84995|Rubrobacteria	L	Single-strand binding protein family	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS2_k127_3811190_10	1283299.AUKG01000001_gene1817	1.478e-24	111.0	COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,4CQW6@84995|Rubrobacteria	84995|Rubrobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
TLS2_k127_3811190_9	266117.Rxyl_0851	2.321e-35	146.0	COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria,4CQHN@84995|Rubrobacteria	84995|Rubrobacteria	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
TLS2_k127_3811190_7	1479623.JHEL01000014_gene2214	3.882e-40	154.0	COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4FMHZ@85023|Microbacteriaceae	201174|Actinobacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
TLS2_k127_3812041_9	469383.Cwoe_5812	2.608e-15	76.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4CP8M@84995|Rubrobacteria	84995|Rubrobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS2_k127_3812041_7	1122939.ATUD01000012_gene3145	2.674e-29	131.0	COG0354@1|root,COG0354@2|Bacteria,2GKP0@201174|Actinobacteria,4CQCX@84995|Rubrobacteria	84995|Rubrobacteria	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
TLS2_k127_3812041_5	1521187.JPIM01000050_gene3442	1.152e-70	251.0	COG0614@1|root,COG0614@2|Bacteria,2G6EF@200795|Chloroflexi,376B5@32061|Chloroflexia	32061|Chloroflexia	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS2_k127_3812041_8	1254432.SCE1572_08845	1.365e-17	90.0	COG2146@1|root,COG2146@2|Bacteria,1PBSD@1224|Proteobacteria,438GW@68525|delta/epsilon subdivisions,2X3RQ@28221|Deltaproteobacteria,2YWY3@29|Myxococcales	28221|Deltaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Rieske_2
TLS2_k127_3812041_4	42256.RradSPS_1881	6.261e-74	262.0	COG2423@1|root,COG2423@2|Bacteria,2GJ0U@201174|Actinobacteria,4CPC0@84995|Rubrobacteria	84995|Rubrobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
TLS2_k127_3812041_6	479434.Sthe_1384	6.266e-56	218.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,2G6N4@200795|Chloroflexi,27YBV@189775|Thermomicrobia	189775|Thermomicrobia	K	FeoA	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
TLS2_k127_3812041_3	1123508.JH636439_gene798	6.051e-96	332.0	COG2107@1|root,COG2107@2|Bacteria,2IXIY@203682|Planctomycetes	203682|Planctomycetes	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
TLS2_k127_3812041_0	867903.ThesuDRAFT_00739	1.465e-171	550.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,3WCX5@538999|Clostridiales incertae sedis	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS2_k127_3812041_2	1713.JOFV01000006_gene2802	1.753e-143	480.0	COG2409@1|root,COG2409@2|Bacteria,2GIRQ@201174|Actinobacteria,4F289@85016|Cellulomonadaceae	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_3812041_1	1341151.ASZU01000010_gene1965	9.841e-149	484.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,27AXC@186824|Thermoactinomycetaceae	91061|Bacilli	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_3817979_7	604331.AUHY01000009_gene375	5.841e-22	100.0	COG0649@1|root,COG0649@2|Bacteria,1WI53@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS2_k127_3817979_6	367299.JOEE01000001_gene2050	7.181e-28	127.0	COG0852@1|root,COG0852@2|Bacteria,2GIRH@201174|Actinobacteria,4FENN@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TLS2_k127_3817979_4	298653.Franean1_6093	5.219e-64	231.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,4ERM4@85013|Frankiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TLS2_k127_3817979_8	765914.ThisiDRAFT_0715	1.266e-21	98.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,1S644@1236|Gammaproteobacteria,1WYJ8@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TLS2_k127_3817979_5	316274.Haur_2694	4.291e-30	126.0	COG0316@1|root,COG0316@2|Bacteria,2G705@200795|Chloroflexi,375UK@32061|Chloroflexia	32061|Chloroflexia	S	TIGRFAM iron-sulfur cluster assembly accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_biosyn
TLS2_k127_3817979_2	935836.JAEL01000004_gene2593	3.211e-82	287.0	COG0492@1|root,COG0492@2|Bacteria,1TRPN@1239|Firmicutes,4H9V7@91061|Bacilli,1ZCG0@1386|Bacillus	91061|Bacilli	O	Pyridine nucleotide-disulphide oxidoreductase	trxB1	-	1.18.1.2,1.19.1.1	ko:K21567	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2
TLS2_k127_3817979_0	1313172.YM304_06050	2.151e-170	547.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria,4CMTT@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Fumarate hydratase class II	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
TLS2_k127_3817979_3	2074.JNYD01000013_gene6803	4.079e-67	235.0	COG0546@1|root,COG0546@2|Bacteria,2GIU8@201174|Actinobacteria,4E37S@85010|Pseudonocardiales	201174|Actinobacteria	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_3817979_1	1150864.MILUP08_42435	3.513e-135	438.0	COG0520@1|root,COG0520@2|Bacteria,2GJA4@201174|Actinobacteria,4DC2F@85008|Micromonosporales	201174|Actinobacteria	E	aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_3817979_9	322710.Avin_08460	2.758e-10	63.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_1427,iB21_1397.B21_00586,iBWG_1329.BWG_0499,iE2348C_1286.E2348C_0528,iEC55989_1330.EC55989_0620,iECABU_c1320.ECABU_c06820,iECBD_1354.ECBD_3023,iECB_1328.ECB_00597,iECDH10B_1368.ECDH10B_0589,iECDH1ME8569_1439.ECDH1ME8569_0597,iECD_1391.ECD_00597,iECED1_1282.ECED1_0624,iECH74115_1262.ECH74115_0716,iECIAI1_1343.ECIAI1_0611,iECIAI39_1322.ECIAI39_0603,iECNA114_1301.ECNA114_0567,iECO103_1326.ECO103_0635,iECO111_1330.ECO111_0658,iECO26_1355.ECO26_0702,iECOK1_1307.ECOK1_0638,iECP_1309.ECP_0658,iECS88_1305.ECS88_0669,iECSE_1348.ECSE_0695,iECSF_1327.ECSF_0567,iECSP_1301.ECSP_0681,iECUMN_1333.ECUMN_0720,iECW_1372.ECW_m0682,iECs_1301.ECs0666,iEKO11_1354.EKO11_3238,iETEC_1333.ETEC_0656,iEcDH1_1363.EcDH1_2998,iEcE24377_1341.EcE24377A_0652,iEcHS_1320.EcHS_A0679,iEcSMS35_1347.EcSMS35_0648,iEcolC_1368.EcolC_3017,iG2583_1286.G2583_0791,iJO1366.b0628,iLF82_1304.LF82_1199,iNRG857_1313.NRG857_02855,iSBO_1134.SBO_0492,iSDY_1059.SDY_0550,iSF_1195.SF0653,iSFxv_1172.SFxv_0720,iSSON_1240.SSON_0582,iS_1188.S0675,iSbBS512_1146.SbBS512_E0542,iUMN146_1321.UM146_14375,iUMNK88_1353.UMNK88_663,iUTI89_1310.UTI89_C0631,iWFL_1372.ECW_m0682,iY75_1357.Y75_RS03275,ic_1306.c0718	LIAS_N,Radical_SAM
TLS2_k127_3823270_17	526225.Gobs_1801	0.000146	48.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4EUA5@85013|Frankiales	201174|Actinobacteria	EGP	drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS2_k127_3823270_8	1242864.D187_009576	6.01e-52	201.0	COG1181@1|root,COG1181@2|Bacteria,1R4RC@1224|Proteobacteria	1224|Proteobacteria	M	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4,CPSase_L_D2
TLS2_k127_3823270_11	1449976.KALB_7242	2.226e-31	135.0	COG1171@1|root,COG1171@2|Bacteria,2HYFX@201174|Actinobacteria,4E0RF@85010|Pseudonocardiales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_3823270_5	589865.DaAHT2_2319	6.323e-57	224.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2WJI9@28221|Deltaproteobacteria,2MHSD@213118|Desulfobacterales	28221|Deltaproteobacteria	LU	TIGRFAM DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A,HHH_5
TLS2_k127_3823270_1	266117.Rxyl_1395	6.489e-134	445.0	COG0606@1|root,COG0606@2|Bacteria,2GJIQ@201174|Actinobacteria,4CPKF@84995|Rubrobacteria	84995|Rubrobacteria	O	magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
TLS2_k127_3823270_14	1386089.N865_10215	1.068e-12	80.0	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4FHNM@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the UPF0102 family	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
TLS2_k127_3823270_4	1283299.AUKG01000002_gene4754	4.237e-62	223.0	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,4CQ01@84995|Rubrobacteria	84995|Rubrobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	-	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
TLS2_k127_3823270_9	469383.Cwoe_3678	2.178e-46	169.0	COG0335@1|root,COG0335@2|Bacteria,2IHRT@201174|Actinobacteria,4CQ3H@84995|Rubrobacteria	84995|Rubrobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
TLS2_k127_3823270_10	1121468.AUBR01000050_gene2015	1.241e-41	169.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24HHW@186801|Clostridia,42G4C@68295|Thermoanaerobacterales	186801|Clostridia	U	PFAM Peptidase S24 S26A S26B, conserved region	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
TLS2_k127_3823270_7	1007103.AFHW01000152_gene889	9.598e-54	204.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,26RCU@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
TLS2_k127_3823270_13	936573.HMPREF1147_0683	6.03e-17	87.0	COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,4H56U@909932|Negativicutes	909932|Negativicutes	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
TLS2_k127_3823270_15	1256908.HMPREF0373_01691	3.517e-12	80.0	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,25X88@186806|Eubacteriaceae	186801|Clostridia	S	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
TLS2_k127_3823270_12	661087.HMPREF1008_01384	5.66e-28	114.0	COG0228@1|root,COG0228@2|Bacteria,2IKU0@201174|Actinobacteria,4CWB2@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TLS2_k127_3823270_0	748449.Halha_0625	1.103e-153	497.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,3WAIA@53433|Halanaerobiales	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TLS2_k127_3823270_16	222984.JNCS01000001_gene2024	8.459e-10	68.0	COG3360@1|root,arCOG04561@2157|Archaea,2XZVN@28890|Euryarchaeota,23Y3V@183963|Halobacteria	183963|Halobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
TLS2_k127_3823270_3	1380390.JIAT01000002_gene6014	2.657e-89	300.0	COG4221@1|root,COG4221@2|Bacteria,2IAVE@201174|Actinobacteria,4CR7Q@84995|Rubrobacteria	84995|Rubrobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_3823270_2	266117.Rxyl_1386	4.302e-90	315.0	COG0552@1|root,COG0552@2|Bacteria,2GJQH@201174|Actinobacteria,4CPF9@84995|Rubrobacteria	84995|Rubrobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
TLS2_k127_3823270_6	469383.Cwoe_3688	1.234e-54	196.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4CPIP@84995|Rubrobacteria	84995|Rubrobacteria	D	RecF/RecN/SMC N terminal domain	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
TLS2_k127_3823973_4	1122611.KB903982_gene3560	5.179e-46	173.0	COG0329@1|root,COG0329@2|Bacteria,2GJ34@201174|Actinobacteria,4EFH5@85012|Streptosporangiales	201174|Actinobacteria	EM	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS2_k127_3823973_0	1121468.AUBR01000029_gene1549	5.521e-173	568.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,42F33@68295|Thermoanaerobacterales	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
TLS2_k127_3823973_3	1280954.HPO_15598	2.166e-71	251.0	COG0524@1|root,COG0524@2|Bacteria,1MV5B@1224|Proteobacteria,2UA3V@28211|Alphaproteobacteria,43XQ1@69657|Hyphomonadaceae	28211|Alphaproteobacteria	F	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	GO:0003674,GO:0003824,GO:0004747,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0046835,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS2_k127_3823973_1	1507.HMPREF0262_02192	7.769e-91	314.0	COG1957@1|root,COG1957@2|Bacteria,1TSSS@1239|Firmicutes,24A4D@186801|Clostridia,36FHB@31979|Clostridiaceae	186801|Clostridia	F	Psort location Cytoplasmic, score 7.50	rihA	-	-	ko:K01250	-	-	-	-	ko00000,ko01000	-	-	-	IU_nuc_hydro
TLS2_k127_3823973_2	1380390.JIAT01000010_gene4818	1.245e-80	300.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,4CPHQ@84995|Rubrobacteria	84995|Rubrobacteria	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TLS2_k127_3836843_1	324602.Caur_1216	4.815e-119	387.0	COG1208@1|root,COG1208@2|Bacteria,2G863@200795|Chloroflexi,376T1@32061|Chloroflexia	32061|Chloroflexia	M	TIGRFAM glucose-1-phosphate cytidylyltransferase	-	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
TLS2_k127_3836843_0	365046.Rta_24850	2.001e-180	589.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2VQM9@28216|Betaproteobacteria,4ADI3@80864|Comamonadaceae	28216|Betaproteobacteria	E	homoserine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_3
TLS2_k127_3836843_4	1123368.AUIS01000027_gene1349	5.065e-73	249.0	COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,1S245@1236|Gammaproteobacteria,2NCIQ@225057|Acidithiobacillales	225057|Acidithiobacillales	G	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
TLS2_k127_3836843_2	1408224.SAMCCGM7_c3736	1.162e-111	372.0	COG0451@1|root,COG0451@2|Bacteria,1PB4Y@1224|Proteobacteria,2TTV7@28211|Alphaproteobacteria,4BDWC@82115|Rhizobiaceae	28211|Alphaproteobacteria	GM	GDP-mannose 4,6 dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS2_k127_3836843_3	118173.KB235914_gene3829	9.854e-97	340.0	2DBP2@1|root,2ZA71@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3836843_5	383372.Rcas_1348	2.409e-37	161.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS2_k127_3836843_7	717785.HYPMC_3147	5.912e-26	124.0	COG4464@1|root,COG4464@2|Bacteria,1R5E2@1224|Proteobacteria,2U3T5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	PFAM PHP domain protein	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
TLS2_k127_3836843_6	357808.RoseRS_3121	7.075e-35	151.0	COG0438@1|root,COG0438@2|Bacteria,2G7W6@200795|Chloroflexi,374XV@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_3836843_9	1386969.AWTB01000007_gene2731	1.426e-14	87.0	COG3307@1|root,COG3307@2|Bacteria,2IBTB@201174|Actinobacteria,4GD0G@85026|Gordoniaceae	201174|Actinobacteria	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TLS2_k127_3836843_8	446471.Xcel_2854	5.532e-25	120.0	COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,2GJ1Y@201174|Actinobacteria,4F42F@85017|Promicromonosporaceae	201174|Actinobacteria	M	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA,ParA,Wzz
TLS2_k127_3838186_6	582515.KR51_00011310	9.841e-26	106.0	COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria	1117|Cyanobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS2_k127_3838186_1	469383.Cwoe_4233	1.144e-129	424.0	COG0500@1|root,COG2226@2|Bacteria,2GM2N@201174|Actinobacteria	201174|Actinobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_3838186_0	1283299.AUKG01000001_gene3480	3.723e-143	476.0	COG3546@1|root,COG3546@2|Bacteria,2GKIM@201174|Actinobacteria,4CPK5@84995|Rubrobacteria	84995|Rubrobacteria	P	Manganese containing catalase	-	-	-	-	-	-	-	-	-	-	-	-	Mn_catalase
TLS2_k127_3838186_3	443218.AS9A_2146	4.528e-58	208.0	2CAJE@1|root,33XCP@2|Bacteria,2IMDF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3838186_4	1283299.AUKG01000003_gene247	2.144e-45	176.0	2FHCG@1|root,3496S@2|Bacteria,2H7A4@201174|Actinobacteria,4CQPX@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
TLS2_k127_3838186_2	1122138.AQUZ01000008_gene3640	1.714e-84	292.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,4DNG2@85009|Propionibacteriales	201174|Actinobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
TLS2_k127_3838186_5	1385518.N798_10680	1.625e-30	121.0	COG2234@1|root,COG2234@2|Bacteria,2GIT0@201174|Actinobacteria,4FJVK@85021|Intrasporangiaceae	201174|Actinobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
TLS2_k127_3842284_3	1120948.KB903243_gene2684	9.226e-67	233.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4E1D6@85010|Pseudonocardiales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_3842284_8	1146883.BLASA_3330	6.676e-24	104.0	2BKPP@1|root,32F5B@2|Bacteria,2GZGW@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase propeptide and YPEB domain	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_2
TLS2_k127_3842284_2	1120949.KB903326_gene3159	4.902e-76	265.0	2DN8B@1|root,32W2U@2|Bacteria,2ISPU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3842284_6	557599.MKAN_12225	3.155e-47	173.0	COG0346@1|root,COG0346@2|Bacteria,2IG0S@201174|Actinobacteria,238MB@1762|Mycobacteriaceae	201174|Actinobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_3842284_4	469383.Cwoe_2707	7.948e-58	203.0	COG2207@1|root,COG2207@2|Bacteria,2IFDE@201174|Actinobacteria,4CT1R@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS2_k127_3842284_1	1122611.KB903961_gene4422	1.982e-84	302.0	COG2273@1|root,COG2273@2|Bacteria,2GTJC@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolases family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
TLS2_k127_3842284_7	68260.JOAY01000023_gene2986	1.513e-28	135.0	COG0596@1|root,COG0596@2|Bacteria,2IACG@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_3842284_5	1122182.KB903837_gene3780	4.454e-55	205.0	COG0697@1|root,COG0697@2|Bacteria,2I91Y@201174|Actinobacteria,4DF2R@85008|Micromonosporales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_3842284_0	1121933.AUHH01000009_gene894	7.253e-130	435.0	COG2197@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,4DT1D@85009|Propionibacteriales	201174|Actinobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HD,HD_5
TLS2_k127_3842284_9	479434.Sthe_0104	1.354e-22	103.0	COG4447@1|root,COG4447@2|Bacteria,2G8DW@200795|Chloroflexi,27YX3@189775|Thermomicrobia	189775|Thermomicrobia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3869513_18	1449069.JMLO01000015_gene654	4.196e-19	94.0	COG1215@1|root,COG1215@2|Bacteria,2I2NS@201174|Actinobacteria,4GA0T@85025|Nocardiaceae	201174|Actinobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_3869513_2	469383.Cwoe_1685	9.624e-148	482.0	COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria,4CP8Q@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI
TLS2_k127_3869513_3	1380390.JIAT01000011_gene2865	1.834e-111	373.0	COG1623@1|root,COG1623@2|Bacteria,2GJ41@201174|Actinobacteria,4CPEN@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA integrity scanning protein DisA	-	-	2.7.7.85	ko:K07067	-	-	-	-	ko00000,ko01000	-	-	-	DisA-linker,DisA_N,HHH_2
TLS2_k127_3869513_10	469383.Cwoe_1687	2.573e-64	224.0	COG1329@1|root,COG1329@2|Bacteria,2GKSU@201174|Actinobacteria,4CPVJ@84995|Rubrobacteria	84995|Rubrobacteria	K	CarD-like/TRCF domain	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
TLS2_k127_3869513_15	1120948.KB903229_gene5403	1.152e-38	159.0	COG1211@1|root,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,4DXFF@85010|Pseudonocardiales	201174|Actinobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
TLS2_k127_3869513_14	693746.OBV_23380	1.25e-45	178.0	COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,2N77C@216572|Oscillospiraceae	186801|Clostridia	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
TLS2_k127_3869513_9	1283299.AUKG01000004_gene1147	6.772e-73	253.0	COG1194@1|root,COG1194@2|Bacteria,2GJD9@201174|Actinobacteria,4CQT2@84995|Rubrobacteria	84995|Rubrobacteria	L	endonuclease III	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TLS2_k127_3869513_20	1463879.JOHP01000006_gene6129	0.0001406	54.0	COG1033@1|root,COG1033@2|Bacteria	2|Bacteria	S	growth of symbiont in host cell	MA20_16090	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_3869513_5	497964.CfE428DRAFT_5336	5.827e-104	366.0	COG2230@1|root,COG2230@2|Bacteria,46TH2@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS2_k127_3869513_11	1340493.JNIF01000004_gene1117	4.895e-61	235.0	COG3752@1|root,COG3752@2|Bacteria	2|Bacteria	M	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
TLS2_k127_3869513_6	1384056.N787_09915	6.088e-91	325.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1X2ZB@135614|Xanthomonadales	135614|Xanthomonadales	M	synthase	cfaA	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS2_k127_3869513_13	522373.Smlt2372	9.258e-49	188.0	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,1RRT8@1236|Gammaproteobacteria,1X449@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
TLS2_k127_3869513_4	40571.JOEA01000014_gene2118	1.648e-108	372.0	COG2907@1|root,COG2907@2|Bacteria,2GJMW@201174|Actinobacteria,4E03X@85010|Pseudonocardiales	201174|Actinobacteria	S	amine oxidase	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase,DUF1365
TLS2_k127_3869513_8	469383.Cwoe_4990	1.254e-82	291.0	COG1398@1|root,COG1398@2|Bacteria,2GJJF@201174|Actinobacteria	201174|Actinobacteria	I	PFAM Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
TLS2_k127_3869513_19	1157637.KB892090_gene6138	3.071e-14	81.0	COG1073@1|root,COG1073@2|Bacteria,2I30Z@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
TLS2_k127_3869513_16	479434.Sthe_2391	2.672e-37	147.0	COG3467@1|root,COG3467@2|Bacteria,2G94U@200795|Chloroflexi	200795|Chloroflexi	S	PFAM pyridoxamine 5'-phosphate oxidase-related	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_3869513_12	1121861.KB899930_gene221	6.123e-54	209.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRCI@28211|Alphaproteobacteria,2JPFP@204441|Rhodospirillales	204441|Rhodospirillales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX2	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS2_k127_3869513_7	42256.RradSPS_1857	1.661e-87	298.0	COG0583@1|root,COG0583@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_3869513_0	518766.Rmar_2163	9.427e-213	679.0	COG2225@1|root,COG2225@2|Bacteria,4NF5H@976|Bacteroidetes,1FJVN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Malate synthase	aceB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
TLS2_k127_3869513_1	867903.ThesuDRAFT_01087	3.326e-208	654.0	COG2224@1|root,COG2224@2|Bacteria,1TP1U@1239|Firmicutes	1239|Firmicutes	C	Isocitrate lyase	aceA	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
TLS2_k127_3869513_17	1283299.AUKG01000001_gene3020	5.366e-27	116.0	COG0215@1|root,COG0215@2|Bacteria,2GJF2@201174|Actinobacteria,4CP99@84995|Rubrobacteria	84995|Rubrobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
TLS2_k127_3882588_4	1134912.AJTV01000020_gene3141	8.58e-11	63.0	COG0406@1|root,COG0494@1|root,COG0406@2|Bacteria,COG0494@2|Bacteria,1NPC4@1224|Proteobacteria,2U93I@28211|Alphaproteobacteria,36YU0@31993|Methylocystaceae	28211|Alphaproteobacteria	GL	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1,NUDIX
TLS2_k127_3882588_3	1048339.KB913029_gene1186	1.74e-14	84.0	COG2340@1|root,COG2340@2|Bacteria,2GM57@201174|Actinobacteria,4EWAF@85013|Frankiales	201174|Actinobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
TLS2_k127_3882588_2	1380390.JIAT01000016_gene5642	1.364e-62	228.0	COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria,4CQG8@84995|Rubrobacteria	84995|Rubrobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_3882588_0	469383.Cwoe_3105	2.583e-108	381.0	COG0232@1|root,COG0232@2|Bacteria,2GJ8F@201174|Actinobacteria,4CPM8@84995|Rubrobacteria	84995|Rubrobacteria	F	Phosphohydrolase-associated domain	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
TLS2_k127_3882588_1	1283299.AUKG01000002_gene5285	1.656e-95	333.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4CPNK@84995|Rubrobacteria	84995|Rubrobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
TLS2_k127_3885251_3	1283299.AUKG01000001_gene2027	5.191e-101	336.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4CPU9@84995|Rubrobacteria	84995|Rubrobacteria	L	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
TLS2_k127_3885251_0	266117.Rxyl_2416	1.535e-169	552.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria,4CPWQ@84995|Rubrobacteria	84995|Rubrobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS2_k127_3885251_7	797209.ZOD2009_05557	1.227e-31	130.0	arCOG02998@1|root,arCOG02998@2157|Archaea,2XX29@28890|Euryarchaeota,23VR4@183963|Halobacteria	183963|Halobacteria	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_3885251_1	485913.Krac_11240	1.197e-134	453.0	COG1960@1|root,COG1960@2|Bacteria,2G5K3@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_3885251_8	443255.SCLAV_p0763	0.000129	53.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,2GMNT@201174|Actinobacteria	201174|Actinobacteria	U	Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
TLS2_k127_3885251_4	760568.Desku_2799	2.278e-94	334.0	COG0006@1|root,COG0006@2|Bacteria,1TSXE@1239|Firmicutes,248AF@186801|Clostridia,2604W@186807|Peptococcaceae	186801|Clostridia	E	PFAM peptidase M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
TLS2_k127_3885251_2	326427.Cagg_1321	5.257e-107	366.0	COG1574@1|root,COG1574@2|Bacteria,2G5YJ@200795|Chloroflexi,375CQ@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Amidohydrolase 3	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS2_k127_3885251_6	929712.KI912613_gene2826	4.617e-32	130.0	COG1733@1|root,COG1733@2|Bacteria,2IM83@201174|Actinobacteria,4CQEM@84995|Rubrobacteria	84995|Rubrobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS2_k127_3885251_5	298654.FraEuI1c_2169	1.928e-87	297.0	COG2409@1|root,COG2409@2|Bacteria,2HU5I@201174|Actinobacteria,4EURS@85013|Frankiales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_3894177_0	1121356.AQUW01000003_gene443	3.4e-76	258.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,22JHW@1653|Corynebacteriaceae	201174|Actinobacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
TLS2_k127_3894177_1	156889.Mmc1_0977	6.074e-42	171.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	3-beta hydroxysteroid dehydrogenase	MA20_24380	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind
TLS2_k127_3894177_2	479434.Sthe_2553	2.482e-32	138.0	COG4122@1|root,COG4122@2|Bacteria,2G97D@200795|Chloroflexi,27Y9I@189775|Thermomicrobia	189775|Thermomicrobia	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
TLS2_k127_3894177_3	469383.Cwoe_5395	4.612e-31	124.0	COG2146@1|root,COG2146@2|Bacteria,2HPIQ@201174|Actinobacteria,4CQW9@84995|Rubrobacteria	84995|Rubrobacteria	P	Rieske 2Fe-2S iron-sulphur domain	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
TLS2_k127_3894177_4	1382306.JNIM01000001_gene4002	2.104e-21	96.0	COG0822@1|root,COG0822@2|Bacteria,2G71H@200795|Chloroflexi	200795|Chloroflexi	C	SUF system FeS assembly protein, NifU family	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS2_k127_3930621_1	370438.PTH_1123	1.116e-99	338.0	COG0863@1|root,COG0863@2|Bacteria,1UZ5E@1239|Firmicutes,24F8E@186801|Clostridia	186801|Clostridia	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
TLS2_k127_3930621_7	882083.SacmaDRAFT_0466	1.431e-43	173.0	COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria,4E709@85010|Pseudonocardiales	201174|Actinobacteria	H	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_3930621_13	298655.KI912266_gene1920	4.017e-08	66.0	COG1722@1|root,COG1722@2|Bacteria,2GR0U@201174|Actinobacteria,4ET7C@85013|Frankiales	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
TLS2_k127_3930621_3	710111.FraQA3DRAFT_5481	2.356e-80	282.0	COG1570@1|root,COG1570@2|Bacteria,2GJAS@201174|Actinobacteria,4ERQB@85013|Frankiales	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TLS2_k127_3930621_15	1380347.JNII01000005_gene3498	0.000134	47.0	28THW@1|root,2ZFRR@2|Bacteria,2GQMQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3930621_14	925409.KI911562_gene1382	4.733e-05	56.0	COG2367@1|root,COG2367@2|Bacteria,4PMKC@976|Bacteroidetes,1J006@117747|Sphingobacteriia	976|Bacteroidetes	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
TLS2_k127_3930621_5	298655.KI912266_gene2771	1.423e-63	230.0	28KBH@1|root,2Z9YH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3930621_6	690850.Desaf_2499	1.586e-49	193.0	COG0500@1|root,COG2226@2|Bacteria,1MVXG@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS2_k127_3930621_11	469383.Cwoe_1137	1.55e-10	67.0	2A23K@1|root,30QDU@2|Bacteria,2HRA7@201174|Actinobacteria,4CT74@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3930621_2	1191523.MROS_0061	5.33e-89	302.0	COG0506@1|root,COG0506@2|Bacteria	2|Bacteria	E	proline dehydrogenase activity	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
TLS2_k127_3930621_4	562970.Btus_2604	1.47e-72	256.0	COG1028@1|root,COG1028@2|Bacteria,1TRVE@1239|Firmicutes,4HCFY@91061|Bacilli,27AT7@186823|Alicyclobacillaceae	91061|Bacilli	IQ	KR domain	fabL	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.104	ko:K10780	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R01404,R04430,R04725,R04956,R04959,R04962,R04967,R04970	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_3930621_8	266117.Rxyl_2607	7.035e-34	143.0	COG0697@1|root,COG0697@2|Bacteria,2H1HG@201174|Actinobacteria,4CQ2H@84995|Rubrobacteria	84995|Rubrobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_3930621_9	1304880.JAGB01000003_gene1258	2.241e-26	116.0	COG4359@1|root,COG4359@2|Bacteria,1TSZ9@1239|Firmicutes,24IHI@186801|Clostridia	186801|Clostridia	E	HAD-superfamily hydrolase, subfamily IB, PSPase-like	-	-	3.1.3.87	ko:K08966	ko00270,ko01100,map00270,map01100	M00034	R07394	RC02074	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD,Put_Phosphatase
TLS2_k127_3930621_0	861299.J421_0826	6.066e-119	419.0	COG0076@1|root,COG0076@2|Bacteria,1ZU8Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
TLS2_k127_3930621_10	1110502.TMO_3212	3.229e-24	111.0	COG0122@1|root,COG0122@2|Bacteria	2|Bacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
TLS2_k127_3941808_0	1123024.AUII01000007_gene4843	6.422e-291	913.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4DY9U@85010|Pseudonocardiales	201174|Actinobacteria	C	aconitate hydratase	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS2_k127_3941808_3	1121405.dsmv_3320	1.409e-67	246.0	COG4325@1|root,COG4325@2|Bacteria,1MXTM@1224|Proteobacteria,42NU4@68525|delta/epsilon subdivisions,2WKV0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
TLS2_k127_3941808_1	1090320.KB900608_gene239	1.006e-158	525.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2TRXF@28211|Alphaproteobacteria,2K06B@204457|Sphingomonadales	204457|Sphingomonadales	P	chromate transporter	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
TLS2_k127_3941808_4	378806.STAUR_6242	1.156e-48	198.0	COG3145@1|root,COG3145@2|Bacteria,1RDBK@1224|Proteobacteria	1224|Proteobacteria	L	Pfam 2OG-Fe(II) oxygenase	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
TLS2_k127_3941808_2	1380390.JIAT01000016_gene5611	9.875e-91	323.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4CPTS@84995|Rubrobacteria	84995|Rubrobacteria	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_3941808_5	945713.IALB_1286	1.03e-13	84.0	COG2170@1|root,COG2170@2|Bacteria	2|Bacteria	S	glutamate-cysteine ligase activity	ybdK	GO:0003674,GO:0003824,GO:0016874,GO:0016879	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
TLS2_k127_3997301_4	1283299.AUKG01000001_gene3220	2.183e-43	162.0	COG1113@1|root,COG1113@2|Bacteria,2HQNZ@201174|Actinobacteria,4CS9Z@84995|Rubrobacteria	84995|Rubrobacteria	E	amino acid transport	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_3997301_0	251221.35212730	5.544e-206	662.0	COG0843@1|root,COG0843@2|Bacteria,1G1ME@1117|Cyanobacteria	1117|Cyanobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	cyoB	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS2_k127_3997301_1	469383.Cwoe_1903	3.772e-76	267.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,2GNXA@201174|Actinobacteria	201174|Actinobacteria	C	I and II form the functional core of the enzyme complex. electrons originating in cytochrome C are transferred via HemE a and cu(a) to the binuclear center formed by HemE A3 and cu(B)	ctaC	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
TLS2_k127_3997301_2	1394178.AWOO02000057_gene688	1.81e-69	248.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria,4EHIV@85012|Streptosporangiales	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
TLS2_k127_3997301_3	649743.HMPREF0972_01410	7.358e-65	228.0	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,4D45F@85005|Actinomycetales	201174|Actinobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0008150,GO:0040007	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
TLS2_k127_4009001_1	345341.KUTG_01890	1.594e-74	261.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,2HPPU@201174|Actinobacteria,4EB2Z@85010|Pseudonocardiales	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4009001_0	106370.Francci3_2511	1.891e-97	327.0	COG2132@1|root,COG2132@2|Bacteria,2GPUP@201174|Actinobacteria,4ES9Q@85013|Frankiales	201174|Actinobacteria	Q	Multicopper oxidase	aniA	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
TLS2_k127_4033626_0	266117.Rxyl_0904	3.893e-219	691.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_4033626_1	1229780.BN381_430027	2.874e-144	474.0	COG0161@1|root,COG0161@2|Bacteria,2GKF6@201174|Actinobacteria,3UWEC@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Aminotransferase class-III	tpa	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
TLS2_k127_4033626_3	797209.ZOD2009_20028	6.341e-15	83.0	COG0346@1|root,arCOG02708@2157|Archaea,2XZ2Z@28890|Euryarchaeota,23X02@183963|Halobacteria	183963|Halobacteria	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4033626_2	180281.CPCC7001_2321	1.2e-30	137.0	COG0150@1|root,COG0150@2|Bacteria,1G1WY@1117|Cyanobacteria,22SC8@167375|Cyanobium	1117|Cyanobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS2_k127_404980_5	1380390.JIAT01000011_gene2334	1.982e-22	105.0	28MY8@1|root,32YD0@2|Bacteria,2HR9A@201174|Actinobacteria,4CT5U@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_404980_1	246196.MSMEI_4321	1.043e-108	388.0	COG2197@1|root,COG2909@1|root,COG2197@2|Bacteria,COG2909@2|Bacteria,2IBM2@201174|Actinobacteria,2366A@1762|Mycobacteriaceae	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE
TLS2_k127_404980_2	1380390.JIAT01000011_gene2335	6.704e-78	269.0	COG2197@1|root,COG2197@2|Bacteria,2IIDD@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_404980_3	469383.Cwoe_1500	4.1e-34	141.0	COG2197@1|root,COG2197@2|Bacteria,2INZX@201174|Actinobacteria	201174|Actinobacteria	T	Pfam Response regulator receiver	-	-	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
TLS2_k127_404980_0	1380390.JIAT01000011_gene2360	1.721e-111	382.0	COG4585@1|root,COG4585@2|Bacteria,2GMMU@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS2_k127_404980_4	1121946.AUAX01000010_gene3769	1.305e-29	123.0	2AY0M@1|root,31Q26@2|Bacteria,2IMBI@201174|Actinobacteria,4DGA5@85008|Micromonosporales	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N,SHOCT
TLS2_k127_4054617_1	1906.SFRA_14685	5.852e-65	228.0	COG0531@1|root,COG0531@2|Bacteria,2GJ75@201174|Actinobacteria	201174|Actinobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease,AA_permease_2
TLS2_k127_4054617_4	1240349.ANGC01000004_gene1724	0.0009897	48.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2GNII@201174|Actinobacteria,4FV1H@85025|Nocardiaceae	201174|Actinobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
TLS2_k127_4054617_0	1463936.JOJI01000001_gene2027	1.188e-128	425.0	COG1748@1|root,COG1748@2|Bacteria	2|Bacteria	E	saccharopine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
TLS2_k127_4054617_2	1463879.JOHP01000037_gene6922	1.279e-60	224.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,TIR_2
TLS2_k127_4054617_3	1229780.BN381_130143	3.474e-08	55.0	2DREZ@1|root,33BFB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4063605_1	1111069.TCCBUS3UF1_520	5.14e-83	279.0	COG1866@1|root,COG1866@2|Bacteria,1WIQ3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
TLS2_k127_4063605_0	469383.Cwoe_5284	8.757e-170	556.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4CP7M@84995|Rubrobacteria	84995|Rubrobacteria	C	Fumarate reductase flavoprotein C-term	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS2_k127_4063605_2	1123321.KB905813_gene1195	1.153e-15	92.0	2DPU0@1|root,333DA@2|Bacteria,2IARZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4068489_9	648757.Rvan_0240	1.592e-57	204.0	COG0824@1|root,COG0824@2|Bacteria,1RGZN@1224|Proteobacteria,2U95R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
TLS2_k127_4068489_3	1380390.JIAT01000009_gene2047	1.219e-128	445.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4CRXQ@84995|Rubrobacteria	84995|Rubrobacteria	C	FAD linked oxidases, C-terminal domain	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_4068489_0	266117.Rxyl_2745	3.52e-185	603.0	COG0624@1|root,COG0624@2|Bacteria,2GJDE@201174|Actinobacteria,4CP9A@84995|Rubrobacteria	201174|Actinobacteria	E	TIGRFAM Amidase, hydantoinase carbamoylase	-	-	3.5.1.6,3.5.1.87,3.5.3.9	ko:K02083,ko:K06016	ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120	M00046	R00905,R02423,R04666	RC00064,RC00096	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_4068489_5	84531.JMTZ01000030_gene181	1.476e-103	350.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,1RSGE@1236|Gammaproteobacteria,1X4EY@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_4068489_7	994479.GL877878_gene3054	4.513e-72	253.0	COG0388@1|root,COG0388@2|Bacteria,2GKRJ@201174|Actinobacteria,4EESA@85010|Pseudonocardiales	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.5.1	ko:K01501	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
TLS2_k127_4068489_12	1134413.ANNK01000094_gene905	1.988e-22	104.0	COG2761@1|root,COG2761@2|Bacteria,1TRSS@1239|Firmicutes,4HEP8@91061|Bacilli,1ZQQD@1386|Bacillus	91061|Bacilli	Q	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
TLS2_k127_4068489_4	1234664.AMRO01000077_gene3471	7.66e-109	371.0	COG0154@1|root,COG0154@2|Bacteria,1TR9X@1239|Firmicutes,4HAYP@91061|Bacilli,1WG7M@129337|Geobacillus	91061|Bacilli	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_4068489_13	161156.JQKW01000012_gene99	5.735e-08	55.0	COG2331@1|root,COG2331@2|Bacteria,2GHZ9@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TLS2_k127_4068489_10	586416.GZ22_02460	3.516e-48	183.0	COG1335@1|root,COG1335@2|Bacteria,1VA32@1239|Firmicutes,4HKVT@91061|Bacilli	91061|Bacilli	Q	Isochorismatase family	-	-	3.5.1.107	ko:K13995	ko00760,ko01120,map00760,map01120	M00622	R03540	RC00950	ko00000,ko00001,ko00002,ko01000	-	-	-	Isochorismatase
TLS2_k127_4068489_1	935840.JAEQ01000006_gene2470	7.136e-167	529.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2TT7X@28211|Alphaproteobacteria,43HEM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Ectoine utilization protein EutC	-	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
TLS2_k127_4068489_14	1173028.ANKO01000116_gene5665	0.0005907	48.0	COG0642@1|root,COG0745@1|root,COG2114@1|root,COG2203@1|root,COG3437@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,1G0F6@1117|Cyanobacteria,1H7AR@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	cyaC	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,Guanylate_cyc,HATPase_c,HisKA,Response_reg
TLS2_k127_4068489_6	246196.MSMEI_0471	2.555e-93	325.0	COG2421@1|root,COG2421@2|Bacteria,2HQSF@201174|Actinobacteria,23817@1762|Mycobacteriaceae	201174|Actinobacteria	C	Acetamidase/Formamidase family	-	-	3.5.1.49	ko:K01455	ko00460,ko00630,ko00910,ko01200,map00460,map00630,map00910,map01200	-	R00524	RC02432,RC02810	ko00000,ko00001,ko01000	-	-	-	FmdA_AmdA
TLS2_k127_4068489_2	469383.Cwoe_5074	5.426e-163	535.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_4068489_11	196162.Noca_4063	8.534e-47	186.0	COG2186@1|root,COG2186@2|Bacteria,2INJC@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_4068489_8	1307436.PBF_16239	2.831e-65	230.0	COG0146@1|root,COG0146@2|Bacteria,1U1N7@1239|Firmicutes,4HBKB@91061|Bacilli,1ZDFI@1386|Bacillus	91061|Bacilli	EQ	COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
TLS2_k127_4072237_9	34007.IT40_15355	4.254e-12	67.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2TR11@28211|Alphaproteobacteria,2PV9I@265|Paracoccus	28211|Alphaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
TLS2_k127_4072237_0	1009370.ALO_09959	5.393e-219	690.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,4H2EY@909932|Negativicutes	909932|Negativicutes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N,OSCP
TLS2_k127_4072237_3	1136417.AZWE01000008_gene2241	5.337e-84	304.0	COG3119@1|root,COG3119@2|Bacteria,2IDUS@201174|Actinobacteria,4DCI6@85008|Micromonosporales	201174|Actinobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_4072237_11	266779.Meso_0155	1.764e-07	57.0	2AGY4@1|root,33HSC@2|Bacteria,1NJ83@1224|Proteobacteria,2UWQN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4072237_1	1150864.MILUP08_43218	1.321e-135	446.0	COG2242@1|root,COG2242@2|Bacteria,2IAR0@201174|Actinobacteria,4D9FM@85008|Micromonosporales	201174|Actinobacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4072237_2	644283.Micau_2846	1.512e-84	307.0	COG3119@1|root,COG3119@2|Bacteria,2IDUS@201174|Actinobacteria,4DCI6@85008|Micromonosporales	201174|Actinobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS2_k127_4072237_6	929712.KI912613_gene2878	5.913e-24	108.0	COG0712@1|root,COG0712@2|Bacteria	2|Bacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02109,ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
TLS2_k127_4072237_7	469383.Cwoe_4622	9.419e-21	98.0	COG0711@1|root,COG0711@2|Bacteria,2HR5V@201174|Actinobacteria,4CT1D@84995|Rubrobacteria	84995|Rubrobacteria	C	ATP synthase B/B' CF(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
TLS2_k127_4072237_8	929712.KI912613_gene2876	8.824e-19	99.0	COG0636@1|root,COG0636@2|Bacteria,2HPGR@201174|Actinobacteria,4CQV2@84995|Rubrobacteria	84995|Rubrobacteria	C	ATP synthase subunit C	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
TLS2_k127_4072237_4	469383.Cwoe_4624	6.751e-70	252.0	COG0356@1|root,COG0356@2|Bacteria,2H3PR@201174|Actinobacteria,4CQG3@84995|Rubrobacteria	84995|Rubrobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
TLS2_k127_4072237_12	1283299.AUKG01000002_gene3883	0.0007687	49.0	2A1TX@1|root,30Q2V@2|Bacteria,2HR8N@201174|Actinobacteria,4CT50@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4072237_10	228405.HNE_1289	3.574e-10	72.0	COG3126@1|root,COG3187@1|root,COG3126@2|Bacteria,COG3187@2|Bacteria,1N8AF@1224|Proteobacteria,2UGPH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Protein conserved in bacteria	-	-	-	ko:K09914	-	-	-	-	ko00000	-	-	-	META,YscW
TLS2_k127_4072237_5	469383.Cwoe_0085	1.11e-59	228.0	COG1817@1|root,COG1817@2|Bacteria,2HQP4@201174|Actinobacteria,4CSA7@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
TLS2_k127_4078048_8	317619.ANKN01000158_gene1830	9.679e-09	57.0	COG2048@1|root,COG2048@2|Bacteria,1G038@1117|Cyanobacteria	1117|Cyanobacteria	C	Heterodisulfide reductase, subunit B	hdrB	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	CCG
TLS2_k127_4078048_4	1444309.JAQG01000099_gene4992	3.024e-35	147.0	COG1408@1|root,COG1408@2|Bacteria,1UU17@1239|Firmicutes,4HC8Q@91061|Bacilli,26UNW@186822|Paenibacillaceae	91061|Bacilli	S	Phosphoesterase	ykuE	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
TLS2_k127_4078048_6	365528.KB891230_gene2035	5.698e-11	71.0	COG3153@1|root,COG3153@2|Bacteria,2GNNB@201174|Actinobacteria,4ERW8@85013|Frankiales	201174|Actinobacteria	S	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_4078048_2	1246995.AFR_09010	3.72e-76	268.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4DB2H@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3708c	Semialdhyde_dh,Semialdhyde_dhC
TLS2_k127_4078048_0	929712.KI912613_gene2599	1.279e-130	435.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4CPEZ@84995|Rubrobacteria	84995|Rubrobacteria	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
TLS2_k127_4078048_3	266117.Rxyl_0510	1.647e-73	264.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4CQ0D@84995|Rubrobacteria	84995|Rubrobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
TLS2_k127_4078048_7	1869.MB27_29915	7.037e-11	64.0	2E62U@1|root,330RX@2|Bacteria,2GTSM@201174|Actinobacteria,4DFDN@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4078048_5	485916.Dtox_0093	9.793e-26	112.0	COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,262CP@186807|Peptococcaceae	186801|Clostridia	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
TLS2_k127_4078048_1	1283299.AUKG01000003_gene500	1.157e-113	385.0	COG2812@1|root,COG2812@2|Bacteria,2GJKA@201174|Actinobacteria,4CP73@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
TLS2_k127_4088750_3	1336233.JAEH01000004_gene1529	0.0002229	48.0	COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,1RSBP@1236|Gammaproteobacteria,2Q8PP@267890|Shewanellaceae	1236|Gammaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS2_k127_4088750_0	1121468.AUBR01000023_gene2754	3.371e-52	199.0	COG2423@1|root,COG2423@2|Bacteria,1TPHM@1239|Firmicutes,24DP8@186801|Clostridia,42GWZ@68295|Thermoanaerobacterales	186801|Clostridia	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
TLS2_k127_4088750_1	68570.DC74_1241	3.564e-30	127.0	COG3467@1|root,COG3467@2|Bacteria,2I2X2@201174|Actinobacteria	201174|Actinobacteria	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS2_k127_4088750_2	246196.MSMEI_3951	3.41e-21	94.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,236HZ@1762|Mycobacteriaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS2_k127_416129_6	929712.KI912613_gene1359	6.393e-74	252.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4CPYK@84995|Rubrobacteria	84995|Rubrobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_416129_5	469383.Cwoe_0292	1.951e-92	320.0	COG0642@1|root,COG2205@2|Bacteria,2GNUQ@201174|Actinobacteria,4CRHZ@84995|Rubrobacteria	84995|Rubrobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_416129_11	1207063.P24_13141	1.116e-21	109.0	COG1977@1|root,COG1977@2|Bacteria,1N0ZW@1224|Proteobacteria,2UCKF@28211|Alphaproteobacteria,2JU4E@204441|Rhodospirillales	204441|Rhodospirillales	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
TLS2_k127_416129_4	1411123.JQNH01000001_gene808	2.057e-112	374.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2U0UY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
TLS2_k127_416129_8	1380390.JIAT01000010_gene4767	4.808e-31	132.0	COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria,4CT9K@84995|Rubrobacteria	84995|Rubrobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
TLS2_k127_416129_3	469383.Cwoe_2709	1.035e-133	433.0	COG1595@1|root,COG3631@1|root,COG1595@2|Bacteria,COG3631@2|Bacteria,2GMRK@201174|Actinobacteria,4CRR4@84995|Rubrobacteria	201174|Actinobacteria	K	Sigma-70 region 2	sigG	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	NTF2,Sigma70_r2,Sigma70_r4_2,SnoaL_2
TLS2_k127_416129_10	469383.Cwoe_2710	2.297e-22	99.0	COG3113@1|root,COG3113@2|Bacteria	2|Bacteria	S	response to antibiotic	mlaB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716	-	ko:K02066,ko:K04749,ko:K07122	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000,ko03021	3.A.1.27,3.A.1.27.3	-	-	MlaE,STAS_2
TLS2_k127_416129_0	543728.Vapar_4413	2.733e-190	606.0	COG0477@1|root,COG0477@2|Bacteria,1MWXZ@1224|Proteobacteria,2VN35@28216|Betaproteobacteria,4AANB@80864|Comamonadaceae	28216|Betaproteobacteria	P	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_416129_2	882083.SacmaDRAFT_3032	2.964e-149	486.0	COG5276@1|root,COG5276@2|Bacteria,2IAAZ@201174|Actinobacteria,4EAHD@85010|Pseudonocardiales	201174|Actinobacteria	O	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD,P_proprotein
TLS2_k127_416129_1	1128421.JAGA01000004_gene2489	2.234e-163	520.0	COG2141@1|root,COG2141@2|Bacteria,2NQKB@2323|unclassified Bacteria	2|Bacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_416129_12	436229.JOEH01000017_gene6953	0.0001651	54.0	2EUIU@1|root,33N0V@2|Bacteria,2HZ4V@201174|Actinobacteria,2NHK5@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_416129_7	469383.Cwoe_4041	5.12e-70	259.0	COG0604@1|root,COG0604@2|Bacteria,2GMA2@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N
TLS2_k127_416129_9	861299.J421_0551	2.34e-25	106.0	2DNQD@1|root,32YJR@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3303)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3303
TLS2_k127_4176332_1	1122138.AQUZ01000019_gene8188	1.149e-91	315.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	sndH	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS2_k127_4176332_0	479434.Sthe_2344	2.115e-100	338.0	COG2008@1|root,COG2008@2|Bacteria,2G7UV@200795|Chloroflexi,27XVE@189775|Thermomicrobia	189775|Thermomicrobia	E	Beta-eliminating lyase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS2_k127_4176332_2	469383.Cwoe_3666	2.604e-37	153.0	COG1376@1|root,COG1376@2|Bacteria,2HPTN@201174|Actinobacteria,4CR7H@84995|Rubrobacteria	84995|Rubrobacteria	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,YkuD
TLS2_k127_4184388_3	498848.TaqDRAFT_4820	8.732e-42	158.0	COG0825@1|root,COG0825@2|Bacteria,1WJ82@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
TLS2_k127_4184388_2	1122621.ATZA01000012_gene3116	6.615e-185	614.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,4NESR@976|Bacteroidetes,1IQI9@117747|Sphingobacteriia	976|Bacteroidetes	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS2_k127_4184388_1	263358.VAB18032_18980	4.733e-301	953.0	COG3291@1|root,COG3291@2|Bacteria,2I5PU@201174|Actinobacteria,4DMPN@85008|Micromonosporales	201174|Actinobacteria	M	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PA,Peptidase_M36
TLS2_k127_4184388_0	263358.VAB18032_18975	0.0	1042.0	COG3291@1|root,COG3291@2|Bacteria,2I5PU@201174|Actinobacteria,4DMPN@85008|Micromonosporales	201174|Actinobacteria	M	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PA,Peptidase_M36
TLS2_k127_4184388_4	263358.VAB18032_18975	3.036e-11	71.0	COG3291@1|root,COG3291@2|Bacteria,2I5PU@201174|Actinobacteria,4DMPN@85008|Micromonosporales	201174|Actinobacteria	M	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PA,Peptidase_M36
TLS2_k127_4275462_7	702459.BBPR_1308	1.334e-09	58.0	COG0346@1|root,COG0346@2|Bacteria,2II51@201174|Actinobacteria,4D0V7@85004|Bifidobacteriales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	gloA	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_4275462_6	1344012.ATMI01000042_gene516	1.589e-10	75.0	COG5276@1|root,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,1RR7A@1236|Gammaproteobacteria,4BUDR@82986|Tatumella	1236|Gammaproteobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_4275462_2	1122138.AQUZ01000019_gene8187	9.273e-96	348.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4DNJC@85009|Propionibacteriales	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_4275462_4	1122939.ATUD01000001_gene246	9.942e-33	136.0	COG4549@1|root,COG4549@2|Bacteria,2GN9H@201174|Actinobacteria,4CQV6@84995|Rubrobacteria	84995|Rubrobacteria	S	Domain of unkown function (DUF1775)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1775
TLS2_k127_4275462_3	1283299.AUKG01000001_gene1329	6.786e-58	222.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2HZ04@201174|Actinobacteria,4CR0B@84995|Rubrobacteria	84995|Rubrobacteria	P	Copper resistance protein D	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopD
TLS2_k127_4275462_0	1122939.ATUD01000011_gene2256	8.607e-121	398.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4CPFX@84995|Rubrobacteria	84995|Rubrobacteria	V	TIGRFAM daunorubicin resistance ABC transporter ATPase subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4275462_1	469383.Cwoe_0918	2.029e-98	342.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,4CS1F@84995|Rubrobacteria	84995|Rubrobacteria	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
TLS2_k127_4275462_5	479435.Kfla_4814	1.621e-17	84.0	COG0667@1|root,COG0673@1|root,COG0667@2|Bacteria,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,4DT07@85009|Propionibacteriales	201174|Actinobacteria	C	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,GFO_IDH_MocA
TLS2_k127_4303391_4	469383.Cwoe_2844	1.798e-31	130.0	COG2264@1|root,COG2264@2|Bacteria,2GW3S@201174|Actinobacteria,4CP8H@84995|Rubrobacteria	84995|Rubrobacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
TLS2_k127_4303391_1	760568.Desku_2656	1.985e-69	252.0	COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia,25ZY0@186807|Peptococcaceae	186801|Clostridia	J	MiaB-like tRNA modifying enzyme	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TLS2_k127_4303391_5	67352.JODS01000019_gene2707	1.052e-26	112.0	COG0537@1|root,COG0537@2|Bacteria,2IHPT@201174|Actinobacteria	201174|Actinobacteria	FG	Histidine triad (Hit) protein	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
TLS2_k127_4303391_6	1042375.AFPL01000025_gene1228	6.209e-26	115.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,4678Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Yqey-like protein	lporfX	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS2_k127_4303391_0	1380390.JIAT01000016_gene5627	8.843e-132	428.0	COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria,4CPBK@84995|Rubrobacteria	84995|Rubrobacteria	T	PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
TLS2_k127_4303391_8	1118060.CAGZ01000024_gene545	5.988e-15	87.0	COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4CVZI@84998|Coriobacteriia	84998|Coriobacteriia	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
TLS2_k127_4303391_2	500633.CLOHIR_02059	5.321e-52	201.0	COG0671@1|root,COG0818@1|root,COG0671@2|Bacteria,COG0818@2|Bacteria,1VEGR@1239|Firmicutes,248FD@186801|Clostridia,25QEG@186804|Peptostreptococcaceae	186801|Clostridia	IM	Prokaryotic diacylglycerol kinase	dgkA	-	2.7.1.107,2.7.1.66	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240,R05626	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar,PAP2
TLS2_k127_4303391_7	999423.HMPREF9161_00950	1.659e-25	121.0	COG0295@1|root,COG0295@2|Bacteria,1V6IP@1239|Firmicutes	1239|Firmicutes	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
TLS2_k127_4303391_3	469383.Cwoe_2851	3.412e-44	171.0	COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria,4CPY3@84995|Rubrobacteria	84995|Rubrobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
TLS2_k127_4328220_4	1123024.AUII01000019_gene3953	4.134e-68	261.0	COG0174@1|root,COG0174@2|Bacteria,2GK8A@201174|Actinobacteria	201174|Actinobacteria	E	glutamine synthetase	glnT	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
TLS2_k127_4328220_3	1380390.JIAT01000009_gene2076	9.328e-93	328.0	COG3605@1|root,COG3835@1|root,COG3605@2|Bacteria,COG3835@2|Bacteria,2I7AB@201174|Actinobacteria,4CQ23@84995|Rubrobacteria	84995|Rubrobacteria	QT	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HTH_30
TLS2_k127_4328220_2	1121019.AUMN01000004_gene1517	4.207e-123	404.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,1WB4T@1268|Micrococcaceae	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_4328220_0	869210.Marky_1927	2.903e-191	608.0	COG0076@1|root,COG0076@2|Bacteria,1WKXN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	COG0076 Glutamate decarboxylase and related PLP-dependent	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS2_k127_4328220_1	391625.PPSIR1_00812	4.851e-187	599.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
TLS2_k127_4328220_5	391625.PPSIR1_00807	7.135e-64	224.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,43BP2@68525|delta/epsilon subdivisions,2WK8X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	molybdopterin oxidoreductase Fe4S4 region	sfrA	-	1.17.1.10	ko:K05299	ko00680,ko00720,ko01100,ko01120,ko01200,map00680,map00720,map01100,map01120,map01200	M00377	R00134	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4_10,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
TLS2_k127_4685051_5	1382356.JQMP01000004_gene600	2.059e-48	179.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,2G6YQ@200795|Chloroflexi,27Y6P@189775|Thermomicrobia	189775|Thermomicrobia	H	MoaE protein	-	-	2.8.1.12	ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
TLS2_k127_4685051_2	479434.Sthe_0994	1.36e-77	267.0	COG0262@1|root,COG0262@2|Bacteria,2G8NF@200795|Chloroflexi	200795|Chloroflexi	H	PFAM bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_4685051_3	469383.Cwoe_4579	7.617e-77	266.0	COG1994@1|root,COG1994@2|Bacteria,2H6BD@201174|Actinobacteria,4CS7E@84995|Rubrobacteria	84995|Rubrobacteria	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4685051_6	929712.KI912613_gene3570	2.103e-09	70.0	2EGQU@1|root,33AGZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Collagen
TLS2_k127_4685051_4	379066.GAU_2861	7.152e-71	248.0	COG1611@1|root,COG1611@2|Bacteria,1ZT7E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TLS2_k127_4685051_0	483219.LILAB_24505	2.89e-119	397.0	COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria,2YU5T@29|Myxococcales	28221|Deltaproteobacteria	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
TLS2_k127_4685051_1	1380390.JIAT01000009_gene948	5.732e-93	344.0	COG3276@1|root,COG3276@2|Bacteria,2GKF9@201174|Actinobacteria,4CPDU@84995|Rubrobacteria	84995|Rubrobacteria	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_3
TLS2_k127_4706483_0	469383.Cwoe_3187	1.036e-247	777.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4CPMB@84995|Rubrobacteria	84995|Rubrobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TLS2_k127_4706483_1	469383.Cwoe_3774	3.162e-141	464.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4CP75@84995|Rubrobacteria	84995|Rubrobacteria	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_4706483_2	656024.FsymDg_3115	1.515e-24	118.0	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,4EREQ@85013|Frankiales	201174|Actinobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS2_k127_4708242_22	1455608.JDTH01000002_gene2055	4.913e-05	47.0	COG0475@1|root,arCOG01955@2157|Archaea,2XT4U@28890|Euryarchaeota,23SD1@183963|Halobacteria	183963|Halobacteria	P	COG0475 Kef-type K transport systems, membrane components	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
TLS2_k127_4708242_0	469383.Cwoe_3474	2.289e-200	637.0	COG0168@1|root,COG0168@2|Bacteria,2HNZI@201174|Actinobacteria,4CQ92@84995|Rubrobacteria	84995|Rubrobacteria	P	Cation transport protein	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS2_k127_4708242_10	526227.Mesil_3163	4.026e-57	211.0	COG0580@1|root,COG0580@2|Bacteria,1WKA2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
TLS2_k127_4708242_12	469383.Cwoe_1983	6.623e-51	201.0	COG0400@1|root,COG0400@2|Bacteria,2GZKY@201174|Actinobacteria,4CPVW@84995|Rubrobacteria	84995|Rubrobacteria	S	Phospholipase/Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
TLS2_k127_4708242_9	748247.AZKH_4418	8.121e-66	235.0	COG1801@1|root,COG1801@2|Bacteria,1N06I@1224|Proteobacteria,2VJZZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS2_k127_4708242_13	1128421.JAGA01000003_gene3677	8.832e-51	203.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	aprX	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
TLS2_k127_4708242_6	1380390.JIAT01000010_gene4390	2.044e-84	304.0	COG2931@1|root,COG2931@2|Bacteria,2GYC8@201174|Actinobacteria	201174|Actinobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS2_k127_4708242_21	1380391.JIAS01000012_gene4256	3.858e-05	57.0	COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U1YP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
TLS2_k127_4708242_4	1122182.KB903813_gene2669	5.843e-97	339.0	COG1409@1|root,COG1409@2|Bacteria,2IM97@201174|Actinobacteria,4D9VR@85008|Micromonosporales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Metallophos
TLS2_k127_4708242_16	1297742.A176_00262	9.196e-45	183.0	COG1470@1|root,COG2885@1|root,COG4719@1|root,COG1470@2|Bacteria,COG2885@2|Bacteria,COG4719@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF11,OmpA,Phenol_MetA_deg,TSP_3
TLS2_k127_4708242_17	749414.SBI_09019	2.069e-33	138.0	COG4923@1|root,COG4923@2|Bacteria,2IJP8@201174|Actinobacteria	201174|Actinobacteria	K	Protein of unknown function (DUF429)	-	-	-	-	-	-	-	-	-	-	-	-	DUF429
TLS2_k127_4708242_14	318586.Pden_0560	2.426e-46	180.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2PX6S@265|Paracoccus	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS2_k127_4708242_1	105420.BBPO01000032_gene6545	2.551e-151	490.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,2NFKX@228398|Streptacidiphilus	201174|Actinobacteria	J	Seryl-tRNA synthetase N-terminal domain	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TLS2_k127_4708242_11	1121428.DESHY_110521___1	1.034e-54	207.0	COG0561@1|root,COG0561@2|Bacteria,1TREF@1239|Firmicutes,24PNN@186801|Clostridia,2673P@186807|Peptococcaceae	186801|Clostridia	S	HAD-superfamily hydrolase, subfamily IIB	yidA	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
TLS2_k127_4708242_20	477184.KYC_04082	1.208e-11	78.0	COG2010@1|root,COG2010@2|Bacteria,1N7JQ@1224|Proteobacteria,2VUC9@28216|Betaproteobacteria,3T4QK@506|Alcaligenaceae	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	1.8.2.1	ko:K05301	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00528	RC00168	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3
TLS2_k127_4708242_5	1210045.ALNP01000006_gene4919	7.119e-90	316.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase M48B family	htpX1	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS2_k127_4708242_15	469383.Cwoe_1784	2.762e-46	173.0	arCOG04740@1|root,31PZA@2|Bacteria,2GP15@201174|Actinobacteria,4CQ51@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4708242_18	1089550.ATTH01000001_gene2519	1.93e-30	132.0	2CWCM@1|root,32SZF@2|Bacteria,4NSAZ@976|Bacteroidetes	976|Bacteroidetes	S	Domain of unknown function (DUF4260)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4260
TLS2_k127_4708242_19	68219.JNXI01000032_gene7054	4.264e-12	76.0	2DS25@1|root,33E6E@2|Bacteria,2ITEN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4708242_8	1380390.JIAT01000014_gene6233	1.317e-74	258.0	COG1842@1|root,COG1842@2|Bacteria,2GP0K@201174|Actinobacteria,4CPNS@84995|Rubrobacteria	84995|Rubrobacteria	KT	PspA/IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
TLS2_k127_4708242_2	164757.Mjls_3914	1.42e-138	454.0	COG0531@1|root,COG0531@2|Bacteria,2I8PY@201174|Actinobacteria	201174|Actinobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
TLS2_k127_4708242_7	1303518.CCALI_00131	1.61e-79	280.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS2_k127_4708242_3	644283.Micau_3633	6.023e-125	419.0	COG0520@1|root,COG0520@2|Bacteria,2GNM2@201174|Actinobacteria,4DM44@85008|Micromonosporales	201174|Actinobacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS2_k127_4728915_3	1110502.TMO_2985	1.953e-14	73.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,2JQ4B@204441|Rhodospirillales	204441|Rhodospirillales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS2_k127_4728915_2	66692.ABC3850	8.439e-17	85.0	COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,4HKHS@91061|Bacilli,1ZGET@1386|Bacillus	91061|Bacilli	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
TLS2_k127_4728915_1	67257.JODR01000009_gene94	6.923e-38	144.0	COG0640@1|root,COG0640@2|Bacteria,2IQGH@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS2_k127_4728915_4	208439.AJAP_03785	3.475e-07	60.0	2EEB9@1|root,3385K@2|Bacteria,2GTRD@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4728915_0	208444.JNYY01000025_gene5967	0.0	1319.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4DYUS@85010|Pseudonocardiales	201174|Actinobacteria	E	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TLS2_k127_4729825_10	1211815.CBYP010000050_gene568	1.618e-07	63.0	COG2518@1|root,COG2518@2|Bacteria,2IJCN@201174|Actinobacteria,4EVT0@85013|Frankiales	201174|Actinobacteria	O	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_25
TLS2_k127_4729825_0	263358.VAB18032_21235	1.418e-115	379.0	COG1595@1|root,COG1595@2|Bacteria,2GJIZ@201174|Actinobacteria,4DBVJ@85008|Micromonosporales	201174|Actinobacteria	K	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_4729825_1	196490.AUEZ01000019_gene501	8.757e-96	325.0	COG0451@1|root,COG0451@2|Bacteria,1PRZV@1224|Proteobacteria,2V479@28211|Alphaproteobacteria,3JVV0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_4729825_3	1394178.AWOO02000005_gene3698	1.303e-75	259.0	COG0262@1|root,COG0262@2|Bacteria,2GJJD@201174|Actinobacteria	201174|Actinobacteria	H	bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_4729825_9	290397.Adeh_3812	1.538e-23	115.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,43AM1@68525|delta/epsilon subdivisions,2X616@28221|Deltaproteobacteria,2Z388@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_4729825_8	378806.STAUR_7457	7.447e-28	122.0	COG3832@1|root,COG3832@2|Bacteria,1MZXG@1224|Proteobacteria	1224|Proteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_4729825_6	526227.Mesil_1024	7.375e-50	190.0	COG5646@1|root,COG5646@2|Bacteria,1WKCV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS2_k127_4729825_4	929712.KI912613_gene3657	4.407e-63	220.0	COG1917@1|root,COG1917@2|Bacteria,2IFSF@201174|Actinobacteria,4CQ50@84995|Rubrobacteria	84995|Rubrobacteria	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_4729825_5	1380394.JADL01000026_gene4730	6.552e-53	208.0	COG0583@1|root,COG0583@2|Bacteria,1NUAB@1224|Proteobacteria,2TUCY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_4729825_7	935839.JAGJ01000005_gene2780	2.46e-35	143.0	COG2364@1|root,COG2364@2|Bacteria,2GKA1@201174|Actinobacteria,4F4B0@85017|Promicromonosporaceae	201174|Actinobacteria	S	membrane	-	-	-	ko:K07149	-	-	-	-	ko00000	-	-	-	-
TLS2_k127_4729825_2	35754.JNYJ01000016_gene9287	1.844e-83	295.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4DF11@85008|Micromonosporales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_4731825_6	794846.AJQU01000051_gene1302	2.382e-97	327.0	COG1082@1|root,COG1082@2|Bacteria,1R44S@1224|Proteobacteria,2U45I@28211|Alphaproteobacteria,4BCIM@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS2_k127_4731825_3	1128421.JAGA01000001_gene2207	1.139e-117	395.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	2.5.1.26	ko:K00803,ko:K11472	ko00565,ko00630,ko01100,ko01110,ko01120,ko01130,ko04146,map00565,map00630,map01100,map01110,map01120,map01130,map04146	-	R00475,R04311	RC00020,RC00042,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_4731825_11	1396141.BATP01000023_gene694	3.216e-20	104.0	COG1917@1|root,COG1917@2|Bacteria,46WE0@74201|Verrucomicrobia,2IVZR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_4731825_2	42256.RradSPS_2933	3.323e-135	464.0	COG5564@1|root,COG5564@2|Bacteria,2GMW9@201174|Actinobacteria,4CSEH@84995|Rubrobacteria	84995|Rubrobacteria	S	Phosphoenolpyruvate hydrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	PEP_hydrolase
TLS2_k127_4731825_1	1382306.JNIM01000001_gene3220	1.184e-171	547.0	COG5441@1|root,COG5441@2|Bacteria,2G7QM@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterised protein family (UPF0261)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0261
TLS2_k127_4731825_9	309801.trd_A0080	2.81e-80	275.0	COG0410@1|root,COG0410@2|Bacteria,2G69M@200795|Chloroflexi	200795|Chloroflexi	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS2_k127_4731825_5	477641.MODMU_2354	4.539e-98	334.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4EVN5@85013|Frankiales	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_4731825_4	477641.MODMU_2361	5.294e-114	383.0	COG0683@1|root,COG0683@2|Bacteria,2I9XT@201174|Actinobacteria	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_4731825_8	477641.MODMU_2355	3.737e-84	309.0	COG4177@1|root,COG4177@2|Bacteria,2IE4E@201174|Actinobacteria	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_4731825_7	1380393.JHVP01000005_gene3746	8.353e-96	325.0	COG0559@1|root,COG0559@2|Bacteria,2GKAR@201174|Actinobacteria,4EW1R@85013|Frankiales	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K11960	ko02010,ko02024,map02010,map02024	M00237,M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
TLS2_k127_4731825_0	1382306.JNIM01000001_gene3339	6.385e-174	565.0	COG0129@1|root,COG0129@2|Bacteria,2G67Z@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS2_k127_4731825_10	68260.JOAY01000079_gene2404	6.817e-50	182.0	COG3386@1|root,COG3386@2|Bacteria,2GNV1@201174|Actinobacteria	201174|Actinobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
TLS2_k127_4746951_11	929712.KI912613_gene1832	1.77e-35	139.0	COG1721@1|root,COG1721@2|Bacteria,2GK9A@201174|Actinobacteria,4CPKB@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_4746951_3	266117.Rxyl_1602	8.137e-70	248.0	COG0796@1|root,COG0796@2|Bacteria,2GN4I@201174|Actinobacteria,4CQ0N@84995|Rubrobacteria	84995|Rubrobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
TLS2_k127_4746951_2	1125863.JAFN01000001_gene2879	6.742e-74	269.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,42NEX@68525|delta/epsilon subdivisions,2WJ1Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
TLS2_k127_4746951_7	266117.Rxyl_2934	3.116e-45	174.0	COG1285@1|root,COG1285@2|Bacteria,2GJF0@201174|Actinobacteria	201174|Actinobacteria	S	PFAM MgtC SapB transporter	mgtC	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
TLS2_k127_4746951_10	1313304.CALK_0256	5.996e-36	152.0	COG0127@1|root,COG0127@2|Bacteria	2|Bacteria	F	nucleoside triphosphate catabolic process	rdgB	-	3.6.1.66,5.1.1.3	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	-	R00260,R00426,R00720,R01855,R02100,R02720,R03531	RC00002,RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Ham1p_like
TLS2_k127_4746951_12	1229780.BN381_90008	1.125e-24	108.0	COG0664@1|root,COG0664@2|Bacteria,2GYD2@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
TLS2_k127_4746951_14	1123226.KB899279_gene2443	1.128e-12	78.0	COG1295@1|root,COG1295@2|Bacteria,1U7HM@1239|Firmicutes,4H9MJ@91061|Bacilli,26SZA@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the UPF0761 family	yihY	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_4746951_8	1041930.Mtc_0823	2.553e-42	164.0	COG0461@1|root,arCOG00029@2157|Archaea,2XVNG@28890|Euryarchaeota,2N9UY@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
TLS2_k127_4746951_13	1283299.AUKG01000001_gene3185	3.173e-22	111.0	COG0776@1|root,COG0776@2|Bacteria,2HRDQ@201174|Actinobacteria,4CTBM@84995|Rubrobacteria	84995|Rubrobacteria	L	bacterial (prokaryotic) histone like domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DNA_binding
TLS2_k127_4746951_9	1298863.AUEP01000007_gene386	9.521e-40	150.0	2C6EM@1|root,2ZFYQ@2|Bacteria,2GXX8@201174|Actinobacteria	201174|Actinobacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
TLS2_k127_4746951_4	644283.Micau_4557	1.628e-61	234.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,2GMC0@201174|Actinobacteria,4DAYB@85008|Micromonosporales	201174|Actinobacteria	L	DNA polymerase III, epsilon subunit	dnaQ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
TLS2_k127_4746951_6	292459.STH1244	1.566e-52	212.0	COG0284@1|root,COG0284@2|Bacteria,1TQ7P@1239|Firmicutes,247SZ@186801|Clostridia	186801|Clostridia	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17585	OMPdecase
TLS2_k127_4746951_15	926692.AZYG01000051_gene1870	6.728e-06	58.0	COG1388@1|root,COG1388@2|Bacteria,1V10C@1239|Firmicutes	1239|Firmicutes	M	PFAM LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
TLS2_k127_4746951_5	266117.Rxyl_2298	1.724e-55	209.0	COG1686@1|root,COG1686@2|Bacteria,2GJ7C@201174|Actinobacteria,4CP6F@84995|Rubrobacteria	84995|Rubrobacteria	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
TLS2_k127_4746951_1	1380390.JIAT01000014_gene6094	1.743e-92	316.0	COG1105@1|root,COG1105@2|Bacteria,2GK7E@201174|Actinobacteria,4CQ17@84995|Rubrobacteria	84995|Rubrobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.56	ko:K00882	ko00051,map00051	-	R02071	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS2_k127_4746951_0	1283299.AUKG01000001_gene3190	9.546e-103	340.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4CP9K@84995|Rubrobacteria	84995|Rubrobacteria	F	IMP dehydrogenase GMP reductase	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
TLS2_k127_4748920_2	1869.MB27_11920	1.156e-30	140.0	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria,4D9GA@85008|Micromonosporales	201174|Actinobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
TLS2_k127_4748920_1	443218.AS9A_2146	4.806e-45	172.0	2CAJE@1|root,33XCP@2|Bacteria,2IMDF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4748920_0	1027371.GOALK_014_00450	3.105e-63	237.0	COG0596@1|root,COG0596@2|Bacteria,2HKK5@201174|Actinobacteria,4GDK9@85026|Gordoniaceae	201174|Actinobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_4748920_3	484770.UFO1_1182	2.773e-28	127.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,4H387@909932|Negativicutes	909932|Negativicutes	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4775655_2	1298863.AUEP01000004_gene2193	1.033e-103	349.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4DP2S@85009|Propionibacteriales	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
TLS2_k127_4775655_5	290397.Adeh_0132	1.657e-31	139.0	COG1716@1|root,COG2199@1|root,COG1716@2|Bacteria,COG3706@2|Bacteria,1MVME@1224|Proteobacteria,43AKG@68525|delta/epsilon subdivisions,2X60I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GGDEF
TLS2_k127_4775655_4	880073.Calab_2121	1.634e-56	202.0	COG0048@1|root,COG0048@2|Bacteria,2NPA7@2323|unclassified Bacteria	2|Bacteria	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
TLS2_k127_4775655_3	1380390.JIAT01000011_gene2583	8.313e-66	227.0	COG0049@1|root,COG0049@2|Bacteria,2GMVW@201174|Actinobacteria,4CQ77@84995|Rubrobacteria	84995|Rubrobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
TLS2_k127_4775655_0	269799.Gmet_0623	4.172e-308	972.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria,43SV3@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_4775655_1	760142.Hipma_1392	1.185e-141	454.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2M6A0@213113|Desulfurellales	28221|Deltaproteobacteria	J	GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TLS2_k127_4797524_5	67267.JNXT01000027_gene1331	3.726e-27	123.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_4797524_2	1121468.AUBR01000045_gene1811	1.098e-93	331.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,248CR@186801|Clostridia,42EYR@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TLS2_k127_4797524_1	1380390.JIAT01000009_gene1773	1.961e-100	345.0	COG0515@1|root,COG0515@2|Bacteria,2GNG1@201174|Actinobacteria,4CPQV@84995|Rubrobacteria	84995|Rubrobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_4797524_0	743525.TSC_c12900	3.043e-129	428.0	COG0160@1|root,COG0160@2|Bacteria,1WIP2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_4797524_3	1203632.HMPREF1300_02321	1.04e-80	275.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,22JHW@1653|Corynebacteriaceae	201174|Actinobacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
TLS2_k127_4797524_4	292459.STH404	2.688e-38	166.0	COG0702@1|root,COG0702@2|Bacteria,1VEC8@1239|Firmicutes,25BCI@186801|Clostridia	186801|Clostridia	GM	NmrA-like family	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
TLS2_k127_4799406_3	1121106.JQKB01000060_gene4894	2.085e-09	61.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,2U77K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	6-phosphogluconolactonase	pgl	-	2.7.1.12,3.1.1.31	ko:K00851,ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R01737,R02035	RC00002,RC00017,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
TLS2_k127_4799406_4	1122609.AUGT01000012_gene4236	5.232e-07	63.0	COG3391@1|root,COG4254@1|root,COG3391@2|Bacteria,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4799406_2	383372.Rcas_2243	2.046e-69	250.0	COG0154@1|root,COG0154@2|Bacteria,2G7S4@200795|Chloroflexi,377YI@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS2_k127_4799406_1	309801.trd_A0395	2.831e-80	293.0	COG0109@1|root,COG1612@1|root,COG0109@2|Bacteria,COG1612@2|Bacteria,2G5UC@200795|Chloroflexi,27XHZ@189775|Thermomicrobia	189775|Thermomicrobia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	COX15-CtaA,UbiA
TLS2_k127_4799406_0	469383.Cwoe_1909	3.45e-152	490.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4CP91@84995|Rubrobacteria	84995|Rubrobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS2_k127_4804180_0	644283.Micau_0010	0.0	1025.0	COG0188@1|root,COG1372@1|root,COG0188@2|Bacteria,COG1372@2|Bacteria,2GJ2Q@201174|Actinobacteria,4DHWX@85008|Micromonosporales	201174|Actinobacteria	L	Intein splicing domain	gyrA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV,Intein_splicing,LAGLIDADG_3
TLS2_k127_4804180_1	648996.Theam_1188	5.855e-240	765.0	COG0187@1|root,COG0187@2|Bacteria,2G3N9@200783|Aquificae	200783|Aquificae	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008150,GO:0008152,GO:0009295,GO:0009330,GO:0009987,GO:0016043,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS2_k127_4804180_4	258533.BN977_02823	2.014e-07	61.0	COG5512@1|root,COG5512@2|Bacteria,2GNQ4@201174|Actinobacteria,232VD@1762|Mycobacteriaceae	201174|Actinobacteria	S	Belongs to the UPF0232 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
TLS2_k127_4804180_3	1380390.JIAT01000009_gene1789	1.08e-68	246.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4CQ4U@84995|Rubrobacteria	84995|Rubrobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_23,SMC_N
TLS2_k127_4804180_2	1283299.AUKG01000001_gene1761	1.25e-94	318.0	COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria,4CP8Y@84995|Rubrobacteria	84995|Rubrobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
TLS2_k127_4820686_1	1122939.ATUD01000011_gene2184	7.673e-98	322.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4CP8M@84995|Rubrobacteria	84995|Rubrobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS2_k127_4820686_7	1232429.CBLL010000038_gene2146	3.316e-29	123.0	COG0234@1|root,COG0234@2|Bacteria,2IKTH@201174|Actinobacteria,1W9DG@1268|Micrococcaceae	201174|Actinobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TLS2_k127_4820686_3	1380390.JIAT01000010_gene4131	6.606e-84	295.0	COG0477@1|root,COG2814@2|Bacteria,2HQMP@201174|Actinobacteria,4CS79@84995|Rubrobacteria	84995|Rubrobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_4820686_6	378806.STAUR_5681	1.071e-35	142.0	COG1051@1|root,COG1051@2|Bacteria,1QX3X@1224|Proteobacteria,437EV@68525|delta/epsilon subdivisions,2X2M4@28221|Deltaproteobacteria,2YZWY@29|Myxococcales	28221|Deltaproteobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_4820686_5	469383.Cwoe_5810	4.286e-37	147.0	COG2411@1|root,COG2411@2|Bacteria,2HNQQ@201174|Actinobacteria,4CPX9@84995|Rubrobacteria	84995|Rubrobacteria	S	ASCH domain	-	-	-	-	-	-	-	-	-	-	-	-	ASCH
TLS2_k127_4820686_2	671143.DAMO_0748	1.882e-95	326.0	COG1071@1|root,COG1071@2|Bacteria,2NPBB@2323|unclassified Bacteria	2|Bacteria	C	Dehydrogenase E1 component	bfmBA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166,ko:K11381,ko:K21416	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
TLS2_k127_4820686_0	234267.Acid_0353	3.741e-119	407.0	COG0022@1|root,COG0022@2|Bacteria,3Y48G@57723|Acidobacteria	57723|Acidobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS2_k127_4820686_4	298653.Franean1_1779	9.464e-41	161.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4ERCG@85013|Frankiales	201174|Actinobacteria	C	TIGRFAM 2-oxoglutarate dehydrogenase, E2 component	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS2_k127_4829157_1	929712.KI912613_gene3423	5.124e-105	356.0	COG1459@1|root,COG1459@2|Bacteria,2GQW0@201174|Actinobacteria,4CPUI@84995|Rubrobacteria	84995|Rubrobacteria	NU	COG COG1459 Type II secretory pathway component PulF Cell motility and secretion Intracellular trafficking and secretion	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
TLS2_k127_4829157_3	266117.Rxyl_1463	5.569e-12	79.0	COG3167@1|root,COG3167@2|Bacteria,2I81H@201174|Actinobacteria	201174|Actinobacteria	NU	Type II secretion system (T2SS), protein M	-	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
TLS2_k127_4829157_4	1121428.DESHY_60047___1	0.0007483	52.0	COG3166@1|root,COG3166@2|Bacteria	2|Bacteria	NU	PFAM Fimbrial assembly family protein	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
TLS2_k127_4829157_2	1283299.AUKG01000004_gene947	4.099e-48	193.0	COG4972@1|root,COG4972@2|Bacteria,2IBNF@201174|Actinobacteria,4CQH2@84995|Rubrobacteria	84995|Rubrobacteria	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
TLS2_k127_4829157_0	1380390.JIAT01000017_gene5297	2.521e-133	435.0	COG2805@1|root,COG2805@2|Bacteria,2I9GT@201174|Actinobacteria,4CPG2@84995|Rubrobacteria	84995|Rubrobacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TLS2_k127_4829157_5	118166.JH976537_gene817	0.0009458	48.0	COG2165@1|root,COG2165@2|Bacteria,1G6VB@1117|Cyanobacteria,1HBR3@1150|Oscillatoriales	1117|Cyanobacteria	NU	Prepilin-type N-terminal cleavage methylation domain	gsp	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin_GH
TLS2_k127_483441_2	253839.SSNG_04385	3.493e-21	107.0	COG3210@1|root,COG3210@2|Bacteria,2IPU7@201174|Actinobacteria	201174|Actinobacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_483441_0	861208.AGROH133_15140	4.071e-61	221.0	COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,2V825@28211|Alphaproteobacteria,4BG91@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
TLS2_k127_483441_3	953739.SVEN_7431	1.148e-16	88.0	2DE7V@1|root,2ZKWZ@2|Bacteria,2IDJ0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_483441_1	338963.Pcar_2169	2.25e-41	160.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,43S0K@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	GatB domain	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
TLS2_k127_4842222_9	999541.bgla_2g19910	5.688e-16	91.0	COG0438@1|root,COG0438@2|Bacteria,1Q2W9@1224|Proteobacteria,2VIFX@28216|Betaproteobacteria,1K5S8@119060|Burkholderiaceae	28216|Betaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2,Glycos_transf_1
TLS2_k127_4842222_7	1095769.CAHF01000008_gene3632	7.561e-83	287.0	COG0859@1|root,COG0859@2|Bacteria,1R57H@1224|Proteobacteria,2VHFC@28216|Betaproteobacteria,476YY@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
TLS2_k127_4842222_0	266117.Rxyl_0717	2.557e-265	827.0	COG2192@1|root,COG2192@2|Bacteria,2GJHV@201174|Actinobacteria,4CPXA@84995|Rubrobacteria	84995|Rubrobacteria	H	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TLS2_k127_4842222_2	266117.Rxyl_0716	9.388e-181	598.0	COG0241@1|root,COG1216@1|root,COG0241@2|Bacteria,COG1216@2|Bacteria,2GK77@201174|Actinobacteria,4CQSE@84995|Rubrobacteria	84995|Rubrobacteria	E	HAD-hyrolase-like	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Glycos_transf_2,Hydrolase_like
TLS2_k127_4842222_3	1380393.JHVP01000008_gene4653	3.005e-117	409.0	COG0859@1|root,COG0859@2|Bacteria,2GSTW@201174|Actinobacteria,4EUEG@85013|Frankiales	201174|Actinobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,Hydrolase_like
TLS2_k127_4842222_1	1380390.JIAT01000010_gene4058	3.141e-223	725.0	COG0279@1|root,COG0297@1|root,COG0279@2|Bacteria,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria,4CQI2@84995|Rubrobacteria	201174|Actinobacteria	G	Starch synthase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_4842222_6	28042.GU90_02820	2.709e-94	317.0	COG4221@1|root,COG4221@2|Bacteria,2HZEI@201174|Actinobacteria,4DXAX@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS2_k127_4842222_4	512565.AMIS_4880	2.237e-106	361.0	COG0535@1|root,COG0535@2|Bacteria,2GTTW@201174|Actinobacteria,4DIAW@85008|Micromonosporales	201174|Actinobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
TLS2_k127_4842222_8	469383.Cwoe_4560	4.957e-50	190.0	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria,4CRKQ@84995|Rubrobacteria	84995|Rubrobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS2_k127_4842222_5	469383.Cwoe_4559	1.929e-100	333.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4CRVP@84995|Rubrobacteria	84995|Rubrobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_4885925_1	867903.ThesuDRAFT_00352	4.58e-66	238.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,3WD0A@538999|Clostridiales incertae sedis	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
TLS2_k127_4885925_0	479434.Sthe_3075	5.022e-93	341.0	COG0642@1|root,COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,2G7SE@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
TLS2_k127_4885925_3	500153.JOEK01000003_gene1080	1.376e-09	64.0	2DUW4@1|root,32UXY@2|Bacteria,2IJWI@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4234)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4234
TLS2_k127_4885925_2	1283299.AUKG01000001_gene1454	4.223e-46	180.0	COG4223@1|root,COG4223@2|Bacteria,2HQ3A@201174|Actinobacteria,4CRJT@84995|Rubrobacteria	84995|Rubrobacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4885925_4	1283299.AUKG01000001_gene1453	9.456e-08	67.0	2AVRV@1|root,31MJ7@2|Bacteria,2HPH2@201174|Actinobacteria,4CQVC@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_4963739_2	526226.Gbro_0449	3.031e-17	85.0	COG0454@1|root,COG0456@2|Bacteria,2HXQB@201174|Actinobacteria,4GGM9@85026|Gordoniaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	ko:K03825	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
TLS2_k127_4963739_3	1038859.AXAU01000020_gene5402	6.626e-10	70.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JVPA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF
TLS2_k127_4963739_1	266117.Rxyl_2954	3.216e-41	159.0	COG2802@1|root,COG2802@2|Bacteria,2HP4R@201174|Actinobacteria,4CQGD@84995|Rubrobacteria	84995|Rubrobacteria	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
TLS2_k127_4963739_0	477974.Daud_1184	1.935e-73	259.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,261NP@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_5052869_4	1156919.QWC_05549	1.807e-16	85.0	COG0526@1|root,COG0526@2|Bacteria,1RAW3@1224|Proteobacteria,2VS2D@28216|Betaproteobacteria,3T4A1@506|Alcaligenaceae	28216|Betaproteobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,LGT,Redoxin,Thioredoxin
TLS2_k127_5052869_3	1430440.MGMSRv2_2088	1.423e-32	142.0	COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria,2JS3U@204441|Rhodospirillales	204441|Rhodospirillales	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
TLS2_k127_5052869_1	485913.Krac_11396	2.078e-108	374.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS2_k127_5052869_2	553385.JEMF01000116_gene539	1.506e-36	145.0	COG3238@1|root,COG3238@2|Bacteria,1N6ZC@1224|Proteobacteria,1S9V7@1236|Gammaproteobacteria,1XMEH@135619|Oceanospirillales	135619|Oceanospirillales	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
TLS2_k127_5052869_5	350058.Mvan_0748	4.9e-08	60.0	COG1008@1|root,COG1008@2|Bacteria,2GR9E@201174|Actinobacteria,23A4I@1762|Mycobacteriaceae	201174|Actinobacteria	C	2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	2TM,DUF1707
TLS2_k127_5052869_0	504728.K649_13155	1.481e-122	400.0	COG0624@1|root,COG0624@2|Bacteria,1WKXT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Peptidase family M28	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_M20
TLS2_k127_50840_0	266117.Rxyl_0189	5.37e-55	210.0	COG0697@1|root,COG0697@2|Bacteria,2GMPJ@201174|Actinobacteria,4CQ3D@84995|Rubrobacteria	84995|Rubrobacteria	EG	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
TLS2_k127_50840_1	1380390.JIAT01000009_gene2064	2.112e-43	177.0	COG1802@1|root,COG1802@2|Bacteria,2HQT3@201174|Actinobacteria,4CSHV@84995|Rubrobacteria	84995|Rubrobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_50840_2	573370.DMR_42770	1.062e-31	136.0	COG0438@1|root,COG0438@2|Bacteria,1RH5W@1224|Proteobacteria,42UY3@68525|delta/epsilon subdivisions,2WQ9B@28221|Deltaproteobacteria,2MA2D@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_5096191_1	44060.JODL01000004_gene2673	1.599e-43	167.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
TLS2_k127_5096191_2	469383.Cwoe_1858	5.97e-29	121.0	2B6US@1|root,31ZU9@2|Bacteria,2HRE3@201174|Actinobacteria,4CTC7@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5096191_0	471852.Tcur_0327	1.306e-145	478.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4EHQQ@85012|Streptosporangiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_5096191_3	645465.ACUR01000585_gene3510	4.826e-09	59.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_5098932_7	300852.55771731	9.101e-23	102.0	COG2905@1|root,COG2905@2|Bacteria,1WJV4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_5098932_2	743718.Isova_1950	1.188e-57	207.0	COG0454@1|root,COG0456@2|Bacteria,2IM2R@201174|Actinobacteria,4F4SX@85017|Promicromonosporaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	ko:K03827	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
TLS2_k127_5098932_0	1198114.AciX9_0458	2.167e-127	425.0	COG0366@1|root,COG0366@2|Bacteria,3Y6QV@57723|Acidobacteria,2JMDJ@204432|Acidobacteriia	204432|Acidobacteriia	G	Alpha-amylase domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
TLS2_k127_5098932_8	953739.SVEN_6939	7.876e-19	101.0	2CIBE@1|root,32S7P@2|Bacteria,2IRU5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5098932_1	1122138.AQUZ01000019_gene8179	2.336e-111	380.0	COG2890@1|root,COG2890@2|Bacteria,2I3R2@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS2_k127_5098932_5	543632.JOJL01000004_gene4319	1.271e-33	148.0	COG1670@1|root,COG1670@2|Bacteria,2IFNY@201174|Actinobacteria,4DEWX@85008|Micromonosporales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS2_k127_5098932_6	381666.H16_B2025	6.362e-25	105.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,1KEBW@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Ribonuclease B OB domain	cspA3	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_5098932_4	574376.BAMA_01820	1.24e-37	159.0	COG2197@1|root,COG2197@2|Bacteria,1TRXG@1239|Firmicutes,4HCCV@91061|Bacilli,1ZDBY@1386|Bacillus	91061|Bacilli	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	yhcZ	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
TLS2_k127_5098932_9	290340.AAur_pTC20128	5.189e-13	83.0	COG0823@1|root,COG3291@1|root,COG5434@1|root,COG0823@2|Bacteria,COG3291@2|Bacteria,COG5434@2|Bacteria,2I2HT@201174|Actinobacteria	201174|Actinobacteria	M	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,FIVAR,Rib
TLS2_k127_5098932_3	1349767.GJA_1458	8.05e-56	222.0	COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,476AX@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	TIGRFAM filamentous hemagglutinin family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ESPR,Glug,Haemagg_act
TLS2_k127_5133173_4	543632.JOJL01000010_gene7190	6.829e-48	175.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria	201174|Actinobacteria	M	sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
TLS2_k127_5133173_6	1123023.JIAI01000002_gene4623	1.114e-35	154.0	COG3919@1|root,COG3919@2|Bacteria,2GM4D@201174|Actinobacteria,4EAB2@85010|Pseudonocardiales	201174|Actinobacteria	S	ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	CPSase_L_D2
TLS2_k127_5133173_0	1380356.JNIK01000011_gene2061	3.814e-74	263.0	COG2348@1|root,COG2348@2|Bacteria,2I7IP@201174|Actinobacteria	201174|Actinobacteria	V	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
TLS2_k127_5133173_1	469383.Cwoe_0096	1.104e-65	250.0	COG1215@1|root,COG1215@2|Bacteria,2GXGY@201174|Actinobacteria,4CS4U@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS2_k127_5133173_12	100226.SCO5682	0.0006922	52.0	2ATXZ@1|root,31JHI@2|Bacteria,2GN21@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
TLS2_k127_5133173_11	1487923.DP73_14520	0.0001113	55.0	COG3307@1|root,COG3307@2|Bacteria,1UYDA@1239|Firmicutes,258NQ@186801|Clostridia,2613J@186807|Peptococcaceae	186801|Clostridia	M	PFAM O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TLS2_k127_5133173_2	1380390.JIAT01000010_gene4522	3.444e-60	227.0	COG1520@1|root,COG1520@2|Bacteria,2HF4U@201174|Actinobacteria,4CPDR@84995|Rubrobacteria	84995|Rubrobacteria	S	PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TLS2_k127_5133173_7	1382306.JNIM01000001_gene3980	1.55e-25	118.0	COG1184@1|root,COG1184@2|Bacteria,2G9CC@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the eIF-2B alpha beta delta subunits family	-	-	-	ko:K03680	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	IF-2B
TLS2_k127_5133173_8	765420.OSCT_1751	1.538e-22	109.0	COG0392@1|root,COG0392@2|Bacteria,2G9P9@200795|Chloroflexi,377PW@32061|Chloroflexia	32061|Chloroflexia	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS2_k127_5133173_5	926554.KI912633_gene3670	1.343e-47	186.0	COG3919@1|root,COG3919@2|Bacteria	2|Bacteria	E	ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,CPSase_L_D2,Dala_Dala_lig_C
TLS2_k127_5133173_10	1123023.JIAI01000015_gene3243	1.577e-12	79.0	COG0101@1|root,COG0500@1|root,COG0101@2|Bacteria,COG2226@2|Bacteria,2I3TI@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	2.1.1.156	ko:K14374,ko:K18896	ko00260,ko00522,ko01052,ko01130,map00260,map00522,map01052,map01130	M00777	R06476,R06477,R06478,R06479,R10060	RC00003,RC00466,RC03038	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_5133173_9	1380390.JIAT01000009_gene747	4.112e-15	89.0	2BR6X@1|root,32K55@2|Bacteria,2HRS7@201174|Actinobacteria,4CTV9@84995|Rubrobacteria	84995|Rubrobacteria	S	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS2_k127_5133173_13	1463921.JODF01000025_gene4595	0.0007674	51.0	COG3206@1|root,COG3206@2|Bacteria,2HSR9@201174|Actinobacteria	201174|Actinobacteria	M	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Wzz
TLS2_k127_5133173_3	469383.Cwoe_5517	6.527e-50	180.0	COG0451@1|root,COG0451@2|Bacteria,2I2EG@201174|Actinobacteria,4CPD2@84995|Rubrobacteria	84995|Rubrobacteria	GM	GDP-mannose 4,6 dehydratase	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS2_k127_5145786_1	590998.Celf_0484	1.938e-70	242.0	COG0262@1|root,COG0262@2|Bacteria,2GKX0@201174|Actinobacteria,4F2KT@85016|Cellulomonadaceae	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_5145786_0	479435.Kfla_1972	3.988e-77	275.0	COG4805@1|root,COG4805@2|Bacteria,2GJQT@201174|Actinobacteria	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5145786_2	1172179.AUKV01000042_gene357	1.992e-68	239.0	COG0702@1|root,COG0702@2|Bacteria,2GKNN@201174|Actinobacteria	201174|Actinobacteria	GM	epimerase dehydratase	yhfK	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
TLS2_k127_5159239_2	1283299.AUKG01000001_gene1792	1.807e-47	192.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4CPG9@84995|Rubrobacteria	84995|Rubrobacteria	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS2_k127_5159239_1	644966.Tmar_1263	3.354e-83	291.0	COG0373@1|root,COG0373@2|Bacteria,1TQN9@1239|Firmicutes,2496M@186801|Clostridia,3WDC1@538999|Clostridiales incertae sedis	186801|Clostridia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
TLS2_k127_5159239_3	1121946.AUAX01000029_gene2012	5.226e-10	71.0	2CNM1@1|root,32SHB@2|Bacteria,2GKWT@201174|Actinobacteria	201174|Actinobacteria	S	Nuclease-related domain	-	-	-	-	-	-	-	-	-	-	-	-	NERD
TLS2_k127_5159239_0	196162.Noca_4966	3.939e-169	551.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria	201174|Actinobacteria	F	Drug exporters of the RND superfamily	-	-	-	ko:K06994,ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_5183416_0	292459.STH1143	1.085e-147	491.0	COG2046@1|root,COG2046@2|Bacteria,1TR4C@1239|Firmicutes,249ZJ@186801|Clostridia	186801|Clostridia	H	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
TLS2_k127_5183416_5	525904.Tter_0038	1.882e-57	216.0	COG0529@1|root,COG0529@2|Bacteria,2NPBJ@2323|unclassified Bacteria	2|Bacteria	P	Catalyzes the synthesis of activated sulfate	cysC	GO:0000096,GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0004779,GO:0004781,GO:0006082,GO:0006520,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010134,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0019379,GO:0019419,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0070566,GO:0071704,GO:1901564	1.8.4.10,1.8.4.8,2.7.1.25,2.7.7.4	ko:K00390,ko:K00860,ko:K00958,ko:K13811	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R02021,R04928,R04929	RC00002,RC00007,RC00078,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
TLS2_k127_5183416_3	1121346.KB899829_gene569	9.281e-71	247.0	COG0175@1|root,COG0175@2|Bacteria,1TSMI@1239|Firmicutes,4HA9E@91061|Bacilli,26SAA@186822|Paenibacillaceae	91061|Bacilli	EH	Belongs to the PAPS reductase family. CysH subfamily	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TLS2_k127_5183416_1	1380390.JIAT01000009_gene1703	1.23e-92	312.0	COG1809@1|root,COG1809@2|Bacteria,2IESE@201174|Actinobacteria,4CRSB@84995|Rubrobacteria	84995|Rubrobacteria	S	(2R)-phospho-3-sulfolactate synthase (ComA)	-	-	4.4.1.19	ko:K08097	ko00680,ko01120,map00680,map01120	M00358	R07476	RC01799	ko00000,ko00001,ko00002,ko01000	-	-	-	ComA
TLS2_k127_5183416_4	767817.Desgi_0076	3.825e-61	230.0	COG1838@1|root,COG1838@2|Bacteria,1TSJ8@1239|Firmicutes,25CDD@186801|Clostridia	186801|Clostridia	C	L( )-tartrate dehydratase subunit beta	ttdB	-	4.2.1.2,4.2.1.32	ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
TLS2_k127_5183416_2	760568.Desku_3251	1.035e-90	314.0	COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,26044@186807|Peptococcaceae	186801|Clostridia	C	Fe-S type, tartrate fumarate subfamily, alpha	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
TLS2_k127_5183416_6	78245.Xaut_3933	9.551e-41	154.0	COG1053@1|root,COG1053@2|Bacteria,1R478@1224|Proteobacteria,2UQPX@28211|Alphaproteobacteria,3F0M5@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	FAD binding domain	-	-	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
TLS2_k127_525923_3	1348663.KCH_31520	2.572e-60	209.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,2M1AY@2063|Kitasatospora	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_525923_2	1123065.ATWL01000005_gene1244	1.068e-95	319.0	COG1012@1|root,COG1012@2|Bacteria,2GKSN@201174|Actinobacteria	201174|Actinobacteria	C	Aldehyde dehydrogenase	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_525923_4	637389.Acaty_c0077	8.894e-08	61.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,2NCIV@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
TLS2_k127_525923_1	867903.ThesuDRAFT_02355	2.447e-110	377.0	COG0421@1|root,COG0421@2|Bacteria,1UI4A@1239|Firmicutes,25GIE@186801|Clostridia	186801|Clostridia	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
TLS2_k127_525923_0	1379698.RBG1_1C00001G1008	4.046e-130	424.0	COG0205@1|root,COG0205@2|Bacteria,2NNY2@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
TLS2_k127_52616_1	469383.Cwoe_1286	5.188e-19	92.0	COG1520@1|root,COG4993@1|root,COG1520@2|Bacteria,COG4993@2|Bacteria,2IAZ2@201174|Actinobacteria	201174|Actinobacteria	KLT	PQQ enzyme repeat	-	-	1.1.2.6,2.7.11.1	ko:K05889,ko:K12132	-	-	R03136	-	ko00000,ko01000,ko01001	-	-	-	PQQ,PQQ_2,PQQ_3,Pkinase
TLS2_k127_52616_0	710111.FraQA3DRAFT_3377	1.523e-116	387.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4EVS8@85013|Frankiales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS2_k127_52616_3	547559.Nmag_1082	4.853e-12	74.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,23VQJ@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_52616_4	1538295.JY96_05760	1.322e-06	60.0	COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VHFJ@28216|Betaproteobacteria,1KNKU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	ko:K11005	-	-	-	-	ko00000,ko02000,ko02042	1.C.11	-	-	HemolysinCabind
TLS2_k127_52616_2	469383.Cwoe_0753	6.544e-14	74.0	COG0433@1|root,COG0433@2|Bacteria,2GKVW@201174|Actinobacteria	201174|Actinobacteria	O	AAA ATPase	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	AAA,DUF87,Zot
TLS2_k127_5402114_4	1158165.KB898873_gene663	1.674e-22	108.0	COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,1RZ5C@1236|Gammaproteobacteria,1WX9Q@135613|Chromatiales	135613|Chromatiales	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_5402114_2	1283299.AUKG01000001_gene1679	2.853e-33	144.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,2HY76@201174|Actinobacteria,4CQCP@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_5402114_3	1121403.AUCV01000047_gene1056	1.388e-31	143.0	COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,42W8F@68525|delta/epsilon subdivisions,2WRG3@28221|Deltaproteobacteria,2MM41@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Glycosyltransferase like family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS2_k127_5402114_0	1122939.ATUD01000010_gene2880	1.836e-77	282.0	COG0371@1|root,COG0371@2|Bacteria,2HRTP@201174|Actinobacteria,4CTX5@84995|Rubrobacteria	84995|Rubrobacteria	C	COG COG0371 Glycerol dehydrogenase and related enzymes Energy production and conversion	-	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
TLS2_k127_5402114_6	1134445.AJJM01000134_gene1143	2.52e-14	86.0	COG1213@1|root,COG1213@2|Bacteria,2GN1Y@201174|Actinobacteria	201174|Actinobacteria	M	transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3,NTP_transferase
TLS2_k127_5402114_5	1120950.KB892752_gene6150	4.134e-18	99.0	COG0558@1|root,COG0558@2|Bacteria,2GJVQ@201174|Actinobacteria,4DV9A@85009|Propionibacteriales	201174|Actinobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
TLS2_k127_5402114_1	634177.GLX_27780	4.61e-37	159.0	COG1216@1|root,COG1216@2|Bacteria,1N72Z@1224|Proteobacteria,2U5XZ@28211|Alphaproteobacteria,2JYTT@204441|Rhodospirillales	204441|Rhodospirillales	S	Glycosyltransferase like family 2	-	-	-	ko:K16555	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	-	Glycos_transf_2
TLS2_k127_5447948_1	929712.KI912613_gene4009	2.224e-91	312.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4CQ0A@84995|Rubrobacteria	84995|Rubrobacteria	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS2_k127_5447948_0	479434.Sthe_3342	7.016e-294	920.0	COG2217@1|root,COG2217@2|Bacteria,2G5S4@200795|Chloroflexi,27YT0@189775|Thermomicrobia	189775|Thermomicrobia	P	E1-E2 ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
TLS2_k127_5447948_2	494419.ALPM01000041_gene2623	4.866e-28	115.0	COG1937@1|root,COG1937@2|Bacteria,2IQAC@201174|Actinobacteria,1W9PZ@1268|Micrococcaceae	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
TLS2_k127_5490532_17	1380390.JIAT01000013_gene212	2.163e-13	83.0	COG0823@1|root,COG0823@2|Bacteria,2I4C3@201174|Actinobacteria,4CQSU@84995|Rubrobacteria	84995|Rubrobacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5490532_14	469383.Cwoe_3719	2.157e-28	119.0	COG2197@1|root,COG2197@2|Bacteria,2I5RT@201174|Actinobacteria	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS2_k127_5490532_3	469383.Cwoe_3718	2.954e-111	385.0	COG4585@1|root,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS2_k127_5490532_8	235985.BBPN01000038_gene514	1.267e-62	242.0	COG2197@1|root,COG2197@2|Bacteria,2GM61@201174|Actinobacteria,2NHCE@228398|Streptacidiphilus	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_5490532_13	313596.RB2501_12022	5.902e-29	127.0	COG0823@1|root,COG0823@2|Bacteria,4NG4S@976|Bacteroidetes,1I1I2@117743|Flavobacteriia	976|Bacteroidetes	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
TLS2_k127_5490532_6	504472.Slin_5292	1.699e-104	355.0	COG1028@1|root,COG1028@2|Bacteria,4NFK6@976|Bacteroidetes,47KDY@768503|Cytophagia	976|Bacteroidetes	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_5490532_19	1380350.JIAP01000004_gene5261	2.118e-07	59.0	COG1917@1|root,COG1917@2|Bacteria,1N1ZP@1224|Proteobacteria,2UE27@28211|Alphaproteobacteria,43PMM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Ethanolamine utilisation protein EutQ	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_5490532_15	68194.JNXR01000011_gene6258	9.99e-21	98.0	COG1846@1|root,COG1846@2|Bacteria,2IIPV@201174|Actinobacteria	201174|Actinobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS2_k127_5490532_11	469383.Cwoe_5358	4.394e-35	141.0	COG2353@1|root,COG2353@2|Bacteria,2H5SM@201174|Actinobacteria	201174|Actinobacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
TLS2_k127_5490532_10	1283299.AUKG01000001_gene1895	1.279e-50	195.0	COG0431@1|root,COG0431@2|Bacteria,2GMA7@201174|Actinobacteria,4CQI6@84995|Rubrobacteria	84995|Rubrobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS2_k127_5490532_5	1120960.ATXG01000017_gene1407	1.677e-107	368.0	COG2267@1|root,COG2267@2|Bacteria,2IB3D@201174|Actinobacteria	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS2_k127_5490532_9	420324.KI912045_gene4359	1.483e-54	198.0	COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,2VEYT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_C_3,GST_N,GST_N_3
TLS2_k127_5490532_12	743525.TSC_c04750	3.205e-30	135.0	COG1196@1|root,COG3593@1|root,COG1196@2|Bacteria,COG3593@2|Bacteria,1WKRH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	COGs COG3593 ATP-dependent endonuclease of the OLD family	-	-	-	ko:K07459	-	-	-	-	ko00000	-	-	-	AAA_15
TLS2_k127_5490532_1	663610.JQKO01000008_gene199	9.489e-159	521.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR56@28211|Alphaproteobacteria,3N9V6@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	haloacid dehalogenase-like hydrolase	cadA	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
TLS2_k127_5490532_4	263358.VAB18032_11730	6.804e-111	391.0	COG2866@1|root,COG2866@2|Bacteria,2GJ8D@201174|Actinobacteria,4DIG8@85008|Micromonosporales	201174|Actinobacteria	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS2_k127_5490532_18	1386089.N865_09665	4.077e-08	66.0	COG1846@1|root,COG1846@2|Bacteria,2GXYR@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5490532_0	483219.LILAB_26095	2.343e-275	873.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2YUAS@29|Myxococcales	28221|Deltaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS2_k127_5490532_7	469371.Tbis_2650	2.573e-96	356.0	COG1262@1|root,COG1262@2|Bacteria,2GK9Q@201174|Actinobacteria,4DZXW@85010|Pseudonocardiales	201174|Actinobacteria	S	Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine	egtB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0019439,GO:0019752,GO:0034641,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052708,GO:0052803,GO:0052805,GO:0055114,GO:0071704,GO:0097164,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	DinB_2,FGE-sulfatase
TLS2_k127_5490532_2	526225.Gobs_0202	5.859e-112	381.0	COG4301@1|root,COG4301@2|Bacteria,2GJAX@201174|Actinobacteria,4ERND@85013|Frankiales	201174|Actinobacteria	S	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine	egtD	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008213,GO:0008276,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016020,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0019439,GO:0019538,GO:0019752,GO:0032259,GO:0034641,GO:0036211,GO:0042398,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052707,GO:0052708,GO:0052709,GO:0052803,GO:0052805,GO:0071704,GO:0071944,GO:0097164,GO:0140096,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
TLS2_k127_5490532_16	266117.Rxyl_3199	2.497e-16	79.0	COG0073@1|root,COG0073@2|Bacteria,2IQBN@201174|Actinobacteria,4CQN2@84995|Rubrobacteria	84995|Rubrobacteria	J	Putative tRNA binding domain	-	-	-	ko:K06878	-	-	-	-	ko00000	-	-	-	tRNA_bind
TLS2_k127_550957_8	1121381.JNIV01000052_gene3313	8.732e-35	136.0	COG2335@1|root,COG2335@2|Bacteria,1WMNY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	COG2335 Secreted and surface protein containing fasciclin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
TLS2_k127_550957_3	1121087.AUCK01000001_gene2648	2.96e-57	210.0	COG1307@1|root,COG1307@2|Bacteria,1TQDI@1239|Firmicutes,4HF8Z@91061|Bacilli,1ZRGY@1386|Bacillus	91061|Bacilli	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
TLS2_k127_550957_9	1206720.BAFQ01000182_gene4705	1.054e-18	99.0	COG2197@1|root,COG2197@2|Bacteria,2GNAU@201174|Actinobacteria,4FZSG@85025|Nocardiaceae	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_550957_1	266117.Rxyl_1369	1.3e-102	354.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4CPUZ@84995|Rubrobacteria	84995|Rubrobacteria	S	Dak1_2	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
TLS2_k127_550957_10	469383.Cwoe_3704	1.085e-18	91.0	COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria,4CQUE@84995|Rubrobacteria	84995|Rubrobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
TLS2_k127_550957_7	861299.J421_3117	1.246e-35	158.0	COG0054@1|root,COG0054@2|Bacteria,1ZTPU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
TLS2_k127_550957_0	469383.Cwoe_3706	2.622e-188	596.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GIWJ@201174|Actinobacteria,4CPH5@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	-	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
TLS2_k127_550957_4	404589.Anae109_2730	3.214e-53	194.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,42QT1@68525|delta/epsilon subdivisions,2WNK6@28221|Deltaproteobacteria,2YVMJ@29|Myxococcales	28221|Deltaproteobacteria	H	riboflavin synthase, alpha	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
TLS2_k127_550957_2	644966.Tmar_1991	1.063e-84	302.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,3WCD3@538999|Clostridiales incertae sedis	186801|Clostridia	H	Riboflavin biosynthesis protein RibD	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
TLS2_k127_550957_6	4909.A0A099NVV6	8.421e-43	175.0	COG0036@1|root,KOG3111@2759|Eukaryota,38G6J@33154|Opisthokonta,3NX48@4751|Fungi,3QPZ3@4890|Ascomycota,3RRMY@4891|Saccharomycetes	4751|Fungi	G	Belongs to the ribulose-phosphate 3-epimerase family	RPE1	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TLS2_k127_550957_5	929712.KI912613_gene4236	3.857e-51	192.0	COG0144@1|root,COG0144@2|Bacteria,2GM21@201174|Actinobacteria,4CPIX@84995|Rubrobacteria	84995|Rubrobacteria	J	16S rRNA methyltransferase RsmB/F	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
TLS2_k127_5616135_2	926550.CLDAP_20350	1.726e-55	197.0	COG0719@1|root,COG0719@2|Bacteria,2G5TI@200795|Chloroflexi	200795|Chloroflexi	O	TIGRFAM FeS assembly protein SufB	sufB	-	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TLS2_k127_5616135_0	926569.ANT_17980	1.963e-91	331.0	COG0396@1|root,COG0396@2|Bacteria,2G5S6@200795|Chloroflexi	200795|Chloroflexi	O	PFAM ABC transporter related	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
TLS2_k127_5616135_5	1382304.JNIL01000001_gene2625	2.391e-12	71.0	COG1826@1|root,COG1826@2|Bacteria,1VFP2@1239|Firmicutes,4HNM7@91061|Bacilli	91061|Bacilli	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS2_k127_5616135_3	869210.Marky_0118	1.013e-30	131.0	COG0805@1|root,COG0805@2|Bacteria,1WJCW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
TLS2_k127_5616135_1	574087.Acear_0510	6.7e-75	278.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,3WB7T@53433|Halanaerobiales	186801|Clostridia	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270	3.5.4.28,3.5.4.31,3.5.4.40	ko:K12960,ko:K20810	ko00130,ko00270,ko01100,ko01110,map00130,map00270,map01100,map01110	-	R09660,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS2_k127_5616135_4	1116232.AHBF01000103_gene6264	2.231e-30	124.0	COG1366@1|root,COG1366@2|Bacteria,2IHQG@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	rsbV	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS2_k127_5616135_6	469383.Cwoe_1897	3.64e-11	71.0	COG2010@1|root,COG3794@1|root,COG2010@2|Bacteria,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	pbrT	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrom_C,Cytochrome_CBB3,FTR1
TLS2_k127_5617311_4	469383.Cwoe_2882	1.009e-25	109.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4CPHN@84995|Rubrobacteria	84995|Rubrobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS2_k127_5617311_1	337191.KTR9_3665	3.923e-58	215.0	COG3693@1|root,COG3693@2|Bacteria,2GN8V@201174|Actinobacteria,4GDMZ@85026|Gordoniaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Glyco_hydro_42
TLS2_k127_5617311_2	337191.KTR9_3665	6.138e-54	203.0	COG3693@1|root,COG3693@2|Bacteria,2GN8V@201174|Actinobacteria,4GDMZ@85026|Gordoniaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Glyco_hydro_42
TLS2_k127_5617311_5	479433.Caci_8563	4.169e-07	60.0	COG3428@1|root,COG3428@2|Bacteria,2IA1C@201174|Actinobacteria	201174|Actinobacteria	K	PFAM Bacterial membrane flanked domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
TLS2_k127_5617311_3	1500890.JQNL01000001_gene2889	3.529e-29	127.0	COG1409@1|root,COG1409@2|Bacteria,1MW6B@1224|Proteobacteria,1S5S8@1236|Gammaproteobacteria,1X5YR@135614|Xanthomonadales	135614|Xanthomonadales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS2_k127_5617311_0	448385.sce7039	1.205e-100	336.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,42Q71@68525|delta/epsilon subdivisions,2WK8Q@28221|Deltaproteobacteria,2YX8I@29|Myxococcales	28221|Deltaproteobacteria	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
TLS2_k127_5626180_9	1120936.KB907225_gene2660	1.707e-33	140.0	COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria,4EFR5@85012|Streptosporangiales	201174|Actinobacteria	T	Lon protease (S16) C-terminal proteolytic domain	lon	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
TLS2_k127_5626180_4	42256.RradSPS_1262	1.224e-120	394.0	COG0039@1|root,COG0039@2|Bacteria,2GN5S@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the LDH MDH superfamily. LDH family	mdh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
TLS2_k127_5626180_1	552811.Dehly_0358	8.435e-152	496.0	COG0473@1|root,COG0473@2|Bacteria,2G68P@200795|Chloroflexi,34D3A@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS2_k127_5626180_2	1283299.AUKG01000001_gene1996	7.949e-134	436.0	COG0372@1|root,COG0372@2|Bacteria,2GKST@201174|Actinobacteria,4CPP8@84995|Rubrobacteria	84995|Rubrobacteria	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS2_k127_5626180_7	525904.Tter_1310	1.291e-41	158.0	COG0288@1|root,COG0288@2|Bacteria,2NR8X@2323|unclassified Bacteria	2|Bacteria	H	Reversible hydration of carbon dioxide	cah	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS2_k127_5626180_0	1043205.AFYF01000051_gene3051	2.244e-158	518.0	COG0471@1|root,COG0471@2|Bacteria,2HXIC@201174|Actinobacteria,4FH0P@85021|Intrasporangiaceae	201174|Actinobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
TLS2_k127_5626180_5	1380390.JIAT01000003_gene5456	2.575e-72	255.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CQMQ@84995|Rubrobacteria	84995|Rubrobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_5626180_6	1380390.JIAT01000010_gene4280	3.001e-57	214.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CSHN@84995|Rubrobacteria	84995|Rubrobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_5626180_10	1048834.TC41_0874	4.823e-11	71.0	COG3361@1|root,COG3361@2|Bacteria,1UYZQ@1239|Firmicutes,4HEHN@91061|Bacilli	91061|Bacilli	S	Uncharacterized conserved protein (COG2071)	yqjF	-	-	ko:K09166	-	-	-	-	ko00000	-	-	-	DUF2071
TLS2_k127_5626180_8	530564.Psta_2352	7.292e-37	158.0	COG4276@1|root,COG4276@2|Bacteria,2J0FI@203682|Planctomycetes	203682|Planctomycetes	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TLS2_k127_5626180_3	1123366.TH3_18083	1.349e-132	433.0	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,2TRC4@28211|Alphaproteobacteria,2JQSD@204441|Rhodospirillales	204441|Rhodospirillales	C	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
TLS2_k127_5630934_4	479434.Sthe_2570	5.442e-17	80.0	COG2151@1|root,COG2151@2|Bacteria,2G9PR@200795|Chloroflexi	200795|Chloroflexi	S	Pfam:DUF59	-	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
TLS2_k127_5630934_2	1283299.AUKG01000001_gene2427	4.346e-63	241.0	COG5373@1|root,COG5373@2|Bacteria,2HRD8@201174|Actinobacteria,4CTAX@84995|Rubrobacteria	84995|Rubrobacteria	S	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
TLS2_k127_5630934_5	408672.NBCG_02651	4.535e-14	83.0	COG3620@1|root,COG3620@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
TLS2_k127_5630934_1	469383.Cwoe_2188	1.702e-69	244.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS2_k127_5630934_0	469383.Cwoe_2187	1.98e-90	313.0	COG1024@1|root,COG1024@2|Bacteria,2I2PC@201174|Actinobacteria,4CU2U@84995|Rubrobacteria	84995|Rubrobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS2_k127_5630934_3	1379698.RBG1_1C00001G0907	7.77e-61	214.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	bamA	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788	3.7.1.21	ko:K07539,ko:K18570	ko00332,ko00362,ko01100,ko01120,ko01130,ko01220,map00332,map00362,map01100,map01120,map01130,map01220	M00541	R05593,R05594,R10696,R10750	RC01430,RC01431,RC03237,RC03270	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS2_k127_5636166_17	543632.JOJL01000006_gene9601	1.015e-22	100.0	COG0671@1|root,COG0671@2|Bacteria,2I8WW@201174|Actinobacteria	201174|Actinobacteria	I	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS2_k127_5636166_9	1144275.COCOR_03158	2.934e-73	261.0	COG3055@1|root,COG3055@2|Bacteria,1MYQG@1224|Proteobacteria,42P3T@68525|delta/epsilon subdivisions,2WKUC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,Kelch_4,PKD
TLS2_k127_5636166_5	1304880.JAGB01000001_gene334	3.561e-113	389.0	COG2132@1|root,COG2132@2|Bacteria,1TQSU@1239|Firmicutes,24CJP@186801|Clostridia	186801|Clostridia	Q	PFAM Multicopper oxidase	-	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
TLS2_k127_5636166_6	1230476.C207_02861	6.801e-100	341.0	COG2114@1|root,COG2114@2|Bacteria,1QWNC@1224|Proteobacteria,2TRQB@28211|Alphaproteobacteria,3JQN6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1,4.6.1.2	ko:K01768,ko:K01769	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,Guanylate_cyc,HAMP
TLS2_k127_5636166_2	351607.Acel_1591	3.201e-214	675.0	COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria,4ERE0@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TLS2_k127_5636166_10	525904.Tter_0195	1.666e-56	216.0	COG0066@1|root,COG0066@2|Bacteria,2NRA0@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2987c	Aconitase_C
TLS2_k127_5636166_11	1118054.CAGW01000015_gene4594	2.397e-55	200.0	28I63@1|root,2Z897@2|Bacteria,1V1EH@1239|Firmicutes	1239|Firmicutes	S	Amino acid synthesis	-	-	-	-	-	-	-	-	-	-	-	-	AA_synth
TLS2_k127_5636166_12	1449126.JQKL01000014_gene3029	8.844e-55	202.0	COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,249YG@186801|Clostridia,269XI@186813|unclassified Clostridiales	186801|Clostridia	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.291,1.1.1.31	ko:K00020,ko:K19647	ko00280,ko00760,ko01100,ko01120,map00280,map00760,map01100,map01120	-	R05066,R07985	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS2_k127_5636166_14	1380390.JIAT01000009_gene2024	3.24e-29	132.0	COG2271@1|root,COG2271@2|Bacteria,2H9HJ@201174|Actinobacteria	201174|Actinobacteria	G	Major facilitator Superfamily	-	-	-	ko:K02445	-	-	-	-	ko00000,ko02000	2.A.1.4.3	-	-	MFS_1
TLS2_k127_5636166_13	867845.KI911784_gene408	9.812e-47	179.0	COG1802@1|root,COG1802@2|Bacteria,2G8RX@200795|Chloroflexi,376HG@32061|Chloroflexia	32061|Chloroflexia	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS2_k127_5636166_3	469383.Cwoe_3975	8.395e-185	591.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4CRFS@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16,2.8.3.20	ko:K07749,ko:K18313	-	-	R10640,R10641	RC00014	ko00000,ko01000	-	-	-	CoA_transf_3
TLS2_k127_5636166_4	266117.Rxyl_1697	7.483e-115	380.0	COG0119@1|root,COG0119@2|Bacteria,2GKTP@201174|Actinobacteria,4CPWV@84995|Rubrobacteria	84995|Rubrobacteria	E	Pyruvate carboxyltransferase	-	-	4.1.3.4,4.1.3.46	ko:K01640,ko:K18314	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090,R10674	RC00502,RC00503,RC01118,RC01205,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS2_k127_5636166_1	383372.Rcas_3493	9.214e-282	882.0	COG0145@1|root,COG0145@2|Bacteria,2GAHE@200795|Chloroflexi,37658@32061|Chloroflexia	32061|Chloroflexia	EQ	Hydantoinase/oxoprolinase N-terminal region	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
TLS2_k127_5636166_0	326427.Cagg_3090	7.311e-314	990.0	COG0146@1|root,COG0146@2|Bacteria,2GAKD@200795|Chloroflexi,376MX@32061|Chloroflexia	32061|Chloroflexia	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
TLS2_k127_5636166_8	266117.Rxyl_1694	2.215e-79	270.0	COG1335@1|root,COG1335@2|Bacteria,2HEVD@201174|Actinobacteria,4CT0H@84995|Rubrobacteria	84995|Rubrobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS2_k127_5636166_7	469383.Cwoe_0733	3.61e-82	299.0	arCOG12117@1|root,2Z9N1@2|Bacteria,2GTM3@201174|Actinobacteria,4CU0S@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function (DUF3891)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3891
TLS2_k127_5636166_15	749927.AMED_1862	3.663e-29	128.0	COG2267@1|root,COG2267@2|Bacteria,2I3KS@201174|Actinobacteria,4E24P@85010|Pseudonocardiales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
TLS2_k127_5636166_16	479434.Sthe_2994	1.312e-27	122.0	COG0687@1|root,COG0687@2|Bacteria	2|Bacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_6,SBP_bac_8
TLS2_k127_5642123_4	395495.Lcho_2660	1.056e-25	109.0	COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,2VJTR@28216|Betaproteobacteria,1KJFA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
TLS2_k127_5642123_5	1122622.ATWJ01000002_gene835	1.401e-25	115.0	COG0368@1|root,COG0368@2|Bacteria,2GKM4@201174|Actinobacteria,4FGPB@85021|Intrasporangiaceae	201174|Actinobacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
TLS2_k127_5642123_2	1242864.D187_008361	2.266e-44	178.0	COG0406@1|root,COG0406@2|Bacteria,1RHAT@1224|Proteobacteria,42SUD@68525|delta/epsilon subdivisions,2WP5H@28221|Deltaproteobacteria,2Z2DD@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphoglycerate mutase family	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TLS2_k127_5642123_3	413816.BBJP01000013_gene885	9.468e-37	149.0	COG1058@1|root,arCOG00215@2157|Archaea,2XUAN@28890|Euryarchaeota,23S6F@183963|Halobacteria	183963|Halobacteria	S	nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA	cinA1	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
TLS2_k127_5642123_0	469383.Cwoe_3589	1.446e-185	628.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4CPKC@84995|Rubrobacteria	84995|Rubrobacteria	L	COG COG0210 Superfamily I DNA and RNA helicases DNA replication recombination and repair	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS2_k127_5642123_1	1380390.JIAT01000009_gene2168	4.764e-71	253.0	COG2132@1|root,COG2132@2|Bacteria,2HPQJ@201174|Actinobacteria,4CR3H@84995|Rubrobacteria	84995|Rubrobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
TLS2_k127_5649818_5	266117.Rxyl_1826	6.176e-12	77.0	COG0491@1|root,COG2897@1|root,COG0491@2|Bacteria,COG2897@2|Bacteria,2GN50@201174|Actinobacteria,4CQ9I@84995|Rubrobacteria	84995|Rubrobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
TLS2_k127_5649818_1	1123023.JIAI01000029_gene4468	2.121e-113	379.0	COG0659@1|root,COG0659@2|Bacteria,2H1V9@201174|Actinobacteria	201174|Actinobacteria	P	Molybdate transporter of MFS superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_MOT1
TLS2_k127_5649818_2	391037.Sare_2827	8.711e-67	239.0	COG0604@1|root,COG0604@2|Bacteria,2GK40@201174|Actinobacteria,4DH8E@85008|Micromonosporales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	fadB5	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
TLS2_k127_5649818_3	469383.Cwoe_5518	9.24e-54	196.0	COG1528@1|root,COG1528@2|Bacteria,2IG5S@201174|Actinobacteria,4CU3R@84995|Rubrobacteria	84995|Rubrobacteria	P	Ferritin-like domain	-	-	1.16.3.1	ko:K22336	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TLS2_k127_5649818_0	1122939.ATUD01000004_gene3936	6.753e-256	798.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,4CPMY@84995|Rubrobacteria	84995|Rubrobacteria	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS2_k127_5653169_19	1173020.Cha6605_5325	9.598e-22	102.0	COG0515@1|root,COG0515@2|Bacteria,1G9K2@1117|Cyanobacteria	1117|Cyanobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5653169_22	1169161.KB897719_gene3648	1.94e-14	80.0	2DWQ8@1|root,341E2@2|Bacteria,2IRXG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5653169_10	469383.Cwoe_1664	3.069e-67	245.0	COG0846@1|root,COG0846@2|Bacteria,2IFPA@201174|Actinobacteria,4CQ9C@84995|Rubrobacteria	84995|Rubrobacteria	K	Sir2 family	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
TLS2_k127_5653169_8	1298863.AUEP01000005_gene2629	3.122e-83	287.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4DWJP@85009|Propionibacteriales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_5653169_15	1385519.N801_12075	7.274e-49	189.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria,4FH4A@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS2_k127_5653169_13	1380347.JNII01000007_gene189	1.017e-57	211.0	2AZ69@1|root,31RD2@2|Bacteria,2ITF8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5653169_1	469383.Cwoe_4536	2.745e-202	647.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,4CPMP@84995|Rubrobacteria	84995|Rubrobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_5,UVR,UvrC_HhH_N
TLS2_k127_5653169_23	1123261.AXDW01000004_gene2728	4.01e-09	62.0	2BISX@1|root,32D0N@2|Bacteria,1N7XS@1224|Proteobacteria,1SD95@1236|Gammaproteobacteria,1XBH6@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5653169_7	1380390.JIAT01000014_gene6134	2.955e-93	328.0	COG0348@1|root,COG0348@2|Bacteria,2I6I5@201174|Actinobacteria,4CS5U@84995|Rubrobacteria	84995|Rubrobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5653169_24	28042.GU90_16835	4.448e-07	58.0	COG1622@1|root,COG1622@2|Bacteria,2GS05@201174|Actinobacteria,4E7MN@85010|Pseudonocardiales	201174|Actinobacteria	C	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
TLS2_k127_5653169_0	518766.Rmar_1231	6.421e-224	722.0	COG1012@1|root,COG1012@2|Bacteria,4NFTW@976|Bacteroidetes,1FIW6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Aldehyde dehydrogenase family	pruA	-	1.2.1.88,1.5.5.2	ko:K00294,ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh
TLS2_k127_5653169_20	530564.Psta_3745	2.793e-20	107.0	COG0350@1|root,COG0350@2|Bacteria,2J0HC@203682|Planctomycetes	203682|Planctomycetes	L	COG0350 Methylated DNA-protein cysteine methyltransferase	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
TLS2_k127_5653169_17	1121468.AUBR01000012_gene2577	1.18e-36	158.0	COG1481@1|root,COG1481@2|Bacteria,1TP2X@1239|Firmicutes,2484M@186801|Clostridia,42EPK@68295|Thermoanaerobacterales	186801|Clostridia	K	May be required for sporulation	whiA	-	-	ko:K09762	-	-	-	-	ko00000	-	-	-	HTH_WhiA,LAGLIDADG_WhiA,WhiA_N
TLS2_k127_5653169_3	469383.Cwoe_4530	3.811e-137	445.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,4CPFY@84995|Rubrobacteria	84995|Rubrobacteria	G	Glyceraldehyde-3-phosphate dehydrogenase, type I	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TLS2_k127_5653169_6	42256.RradSPS_1782	4.011e-114	395.0	COG0126@1|root,COG0126@2|Bacteria,2GJC6@201174|Actinobacteria,4CPN6@84995|Rubrobacteria	84995|Rubrobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
TLS2_k127_5653169_9	404589.Anae109_2280	1.094e-67	248.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,42MIF@68525|delta/epsilon subdivisions,2WIQF@28221|Deltaproteobacteria,2YU88@29|Myxococcales	28221|Deltaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TLS2_k127_5653169_2	644966.Tmar_2240	9.603e-154	511.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,3WCEJ@538999|Clostridiales incertae sedis	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
TLS2_k127_5653169_18	379066.GAU_2442	2.562e-29	124.0	COG1595@1|root,COG1595@2|Bacteria,1ZT3B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_5653169_11	1380370.JIBA01000001_gene2176	1.855e-61	230.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4FIBI@85021|Intrasporangiaceae	201174|Actinobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS2_k127_5653169_12	1283299.AUKG01000002_gene4126	2.029e-60	216.0	COG0639@1|root,COG0639@2|Bacteria,2HNQI@201174|Actinobacteria,4CPX1@84995|Rubrobacteria	84995|Rubrobacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
TLS2_k127_5653169_14	1146883.BLASA_2121	1.028e-55	224.0	COG0501@1|root,COG0501@2|Bacteria,2GRBS@201174|Actinobacteria,4EUSD@85013|Frankiales	201174|Actinobacteria	O	CAAX prenyl protease N-terminal, five membrane helices	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
TLS2_k127_5653169_16	1125718.HMPREF1318_1646	2.715e-43	160.0	COG0346@1|root,COG0346@2|Bacteria,2II51@201174|Actinobacteria,4D5Y6@85005|Actinomycetales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	gloA	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_5653169_5	68170.KL590490_gene1244	2.592e-114	409.0	COG0018@1|root,COG0018@2|Bacteria,2GKQ3@201174|Actinobacteria,4E06T@85010|Pseudonocardiales	201174|Actinobacteria	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
TLS2_k127_5653169_21	887898.HMPREF0551_0096	1.628e-15	87.0	COG0697@1|root,COG0697@2|Bacteria,1N469@1224|Proteobacteria,2VR83@28216|Betaproteobacteria	28216|Betaproteobacteria	EG	permeases of the drug metabolite transporter (Dmt) superfamily	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
TLS2_k127_5653169_4	1237500.ANBA01000018_gene3728	2.828e-121	397.0	COG1494@1|root,COG1494@2|Bacteria,2GMQU@201174|Actinobacteria,4EFSF@85012|Streptosporangiales	201174|Actinobacteria	G	Bacterial fructose-1,6-bisphosphatase, glpX-encoded	glpX	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
TLS2_k127_5656224_0	1283299.AUKG01000001_gene2969	2.121e-28	124.0	COG2197@1|root,COG2197@2|Bacteria,2HU12@201174|Actinobacteria,4CTE1@84995|Rubrobacteria	84995|Rubrobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_5656224_2	1009370.ALO_16741	7.64e-05	51.0	2DXQ1@1|root,345Y4@2|Bacteria,1W1ES@1239|Firmicutes,4H85K@909932|Negativicutes	909932|Negativicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5656224_1	530564.Psta_3892	1.676e-14	76.0	COG1917@1|root,COG1917@2|Bacteria,2J134@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Cupin 2 conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_5659012_4	35754.JNYJ01000021_gene445	0.0007324	51.0	2FBTF@1|root,343Y7@2|Bacteria,2GYVK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5659012_1	1463864.JOGO01000061_gene17	4.414e-27	114.0	COG1695@1|root,COG1695@2|Bacteria,2IQ70@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator padr family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS2_k127_5659012_0	1122138.AQUZ01000019_gene8190	3.311e-241	756.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4DNJC@85009|Propionibacteriales	2|Bacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_5659012_2	875328.JDM601_0889	1.005e-16	86.0	COG1950@1|root,COG1950@2|Bacteria,2IHP5@201174|Actinobacteria,2397Q@1762|Mycobacteriaceae	201174|Actinobacteria	S	membrane	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
TLS2_k127_5659012_3	105422.BBPM01000009_gene6764	1.114e-11	69.0	2AY0M@1|root,31Q26@2|Bacteria,2IMBI@201174|Actinobacteria	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N,SHOCT
TLS2_k127_5667672_1	1283299.AUKG01000002_gene5203	8.736e-74	270.0	COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,4CPDG@84995|Rubrobacteria	84995|Rubrobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS2_k127_5667672_0	469383.Cwoe_3200	4.846e-110	364.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4CPT1@84995|Rubrobacteria	84995|Rubrobacteria	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_5667672_3	1283299.AUKG01000002_gene5205	5.501e-59	210.0	COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria,4CQBB@84995|Rubrobacteria	84995|Rubrobacteria	F	Phosphoribosyl transferase domain	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
TLS2_k127_5667672_2	1380394.JADL01000002_gene1738	8.537e-60	214.0	COG1280@1|root,COG1280@2|Bacteria,1RF1D@1224|Proteobacteria,2VG7N@28211|Alphaproteobacteria,2JYRC@204441|Rhodospirillales	204441|Rhodospirillales	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
TLS2_k127_5690709_0	1454010.JEOE01000045_gene1495	8.827e-149	484.0	COG0557@1|root,COG0557@2|Bacteria,2GNSM@201174|Actinobacteria	201174|Actinobacteria	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
TLS2_k127_5690709_3	47763.JNZA01000018_gene1557	1.093e-21	104.0	COG3467@1|root,COG3467@2|Bacteria,2I2V6@201174|Actinobacteria	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
TLS2_k127_5690709_1	479434.Sthe_2947	8.177e-37	151.0	COG4635@1|root,COG4635@2|Bacteria,2G739@200795|Chloroflexi	200795|Chloroflexi	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
TLS2_k127_5690709_2	1211815.CBYP010000050_gene568	1.222e-35	141.0	COG2518@1|root,COG2518@2|Bacteria,2IJCN@201174|Actinobacteria,4EVT0@85013|Frankiales	201174|Actinobacteria	O	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_25
TLS2_k127_5700707_3	1380390.JIAT01000009_gene1894	8.526e-78	276.0	COG1061@1|root,COG1061@2|Bacteria,2GIR9@201174|Actinobacteria,4CPIG@84995|Rubrobacteria	84995|Rubrobacteria	L	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	ERCC3_RAD25_C,Helicase_C,ResIII
TLS2_k127_5700707_1	1283299.AUKG01000001_gene1973	1.639e-84	289.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4CP8R@84995|Rubrobacteria	84995|Rubrobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
TLS2_k127_5700707_4	106370.Francci3_1653	3.503e-40	166.0	COG1612@1|root,COG1612@2|Bacteria,2GJQX@201174|Actinobacteria,4ESN0@85013|Frankiales	201174|Actinobacteria	O	cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
TLS2_k127_5700707_0	479434.Sthe_0838	4.909e-88	306.0	COG0709@1|root,COG0709@2|Bacteria,2G5W4@200795|Chloroflexi,27XGA@189775|Thermomicrobia	189775|Thermomicrobia	H	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
TLS2_k127_5700707_2	479434.Sthe_2593	1.645e-79	275.0	COG1834@1|root,COG1834@2|Bacteria,2G7QT@200795|Chloroflexi,27YZU@189775|Thermomicrobia	189775|Thermomicrobia	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
TLS2_k127_5700707_5	684949.ATTJ01000001_gene602	1.229e-33	130.0	COG2897@1|root,COG2897@2|Bacteria,1WI0D@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Sulfurtransferase	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS2_k127_5704910_2	1121934.AUDX01000010_gene540	1.424e-35	139.0	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4FKCI@85023|Microbacteriaceae	201174|Actinobacteria	L	MgsA AAA+ ATPase C terminal	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
TLS2_k127_5704910_1	485913.Krac_4785	4.141e-61	226.0	COG0697@1|root,COG0697@2|Bacteria,2G6ZR@200795|Chloroflexi	200795|Chloroflexi	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_5704910_3	1123024.AUII01000005_gene2271	2.231e-35	145.0	COG0596@1|root,COG0596@2|Bacteria,2I8EU@201174|Actinobacteria,4E4HV@85010|Pseudonocardiales	201174|Actinobacteria	S	Serine aminopeptidase, S33	lipV	GO:0003674,GO:0003824,GO:0005488,GO:0005504,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016298,GO:0016787,GO:0016788,GO:0019752,GO:0031406,GO:0032787,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0071704,GO:0072329,GO:0104004,GO:1901575	-	ko:K19311	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS2_k127_5704910_0	562970.Btus_0192	1.344e-73	253.0	COG0010@1|root,COG0010@2|Bacteria,1TR10@1239|Firmicutes,4HAT5@91061|Bacilli,2784I@186823|Alicyclobacillaceae	91061|Bacilli	E	Belongs to the arginase family	rocF	GO:0003674,GO:0003824,GO:0004053,GO:0006082,GO:0006520,GO:0006525,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS2_k127_5705541_21	1121346.KB899818_gene2553	2.467e-12	70.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,4HAG5@91061|Bacilli,26QDU@186822|Paenibacillaceae	91061|Bacilli	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0050896,GO:0051704,GO:0051716,GO:0071496	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TLS2_k127_5705541_23	1238190.AMQY01000011_gene2045	0.0001053	53.0	COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1XM17@135619|Oceanospirillales	135619|Oceanospirillales	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
TLS2_k127_5705541_2	469383.Cwoe_3248	2.56e-164	531.0	COG1418@1|root,COG1418@2|Bacteria,2I9DW@201174|Actinobacteria,4CS83@84995|Rubrobacteria	84995|Rubrobacteria	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
TLS2_k127_5705541_0	1122221.JHVI01000018_gene1496	2.446e-205	700.0	COG2374@1|root,COG2374@2|Bacteria,1WM95@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	U	PFAM Endonuclease Exonuclease phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Exo_endo_phos,LTD
TLS2_k127_5705541_12	32057.KB217478_gene784	6.201e-65	256.0	COG2374@1|root,COG2931@1|root,COG3391@1|root,COG3540@1|root,COG4222@1|root,COG4247@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria,COG3540@2|Bacteria,COG4222@2|Bacteria,COG4247@2|Bacteria,1G0YK@1117|Cyanobacteria,1HM71@1161|Nostocales	1117|Cyanobacteria	Q	phosphatase	-	-	3.1.3.8	ko:K01083,ko:K07004	ko00562,map00562	-	R03371	RC00078	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Calx-beta,DUF4114,Exo_endo_phos,LTD,Phytase-like
TLS2_k127_5705541_6	1121272.KB903272_gene437	5.953e-116	388.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4D8II@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TLS2_k127_5705541_1	84531.JMTZ01000023_gene4233	6.126e-183	624.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1X499@135614|Xanthomonadales	1236|Gammaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small
TLS2_k127_5705541_11	469383.Cwoe_3255	3.094e-65	233.0	COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria,4CQW4@84995|Rubrobacteria	84995|Rubrobacteria	J	IPP transferase	-	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
TLS2_k127_5705541_19	1111479.AXAR01000003_gene1526	3.775e-23	115.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,4HBH4@91061|Bacilli,2789I@186823|Alicyclobacillaceae	91061|Bacilli	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
TLS2_k127_5705541_8	385682.AFSL01000008_gene2528	6.784e-99	347.0	COG2171@1|root,COG2171@2|Bacteria,4NEWD@976|Bacteroidetes,2FRBM@200643|Bacteroidia,3XJUR@558415|Marinilabiliaceae	976|Bacteroidetes	E	Tetrahydrodipicolinate N-succinyltransferase N-terminal	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
TLS2_k127_5705541_4	1283299.AUKG01000002_gene5149	1.436e-130	432.0	COG0436@1|root,COG0436@2|Bacteria,2GJMI@201174|Actinobacteria,4CP8N@84995|Rubrobacteria	84995|Rubrobacteria	E	Aminotransferase class I and II	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS2_k127_5705541_9	1283299.AUKG01000002_gene5148	4.035e-90	308.0	COG0624@1|root,COG0624@2|Bacteria,2GK09@201174|Actinobacteria,4CP61@84995|Rubrobacteria	84995|Rubrobacteria	E	Peptidase dimerisation domain	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_5705541_5	469383.Cwoe_3259	1.161e-128	430.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4CPXQ@84995|Rubrobacteria	84995|Rubrobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TLS2_k127_5705541_15	1122939.ATUD01000005_gene2768	2.053e-49	184.0	COG0756@1|root,COG0756@2|Bacteria,2IHYY@201174|Actinobacteria,4CQCJ@84995|Rubrobacteria	84995|Rubrobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
TLS2_k127_5705541_20	526218.Sterm_1184	1.344e-16	89.0	COG1051@1|root,COG1051@2|Bacteria,37ASE@32066|Fusobacteria	32066|Fusobacteria	F	Hydrolase, NUDIX family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS2_k127_5705541_13	1122939.ATUD01000005_gene2773	1.866e-64	249.0	COG3442@1|root,COG3442@2|Bacteria,2GKPV@201174|Actinobacteria,4CPRV@84995|Rubrobacteria	84995|Rubrobacteria	S	CobB/CobQ-like glutamine amidotransferase domain	-	-	-	ko:K07009	-	-	-	-	ko00000	-	-	-	GATase_3
TLS2_k127_5705541_3	469383.Cwoe_3270	6.514e-136	447.0	COG0771@1|root,COG0771@2|Bacteria,2GK18@201174|Actinobacteria,4CP8D@84995|Rubrobacteria	84995|Rubrobacteria	M	Domain of unknown function (DUF1727)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1727,Mur_ligase_M
TLS2_k127_5705541_14	477974.Daud_0538	8.931e-53	213.0	COG2199@1|root,COG2203@1|root,COG3437@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,1V7YT@1239|Firmicutes,25ET2@186801|Clostridia,267DC@186807|Peptococcaceae	186801|Clostridia	T	Metal-dependent phosphohydrolase, HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HD,PAS,PocR,SBP_bac_3
TLS2_k127_5705541_17	1089550.ATTH01000001_gene2496	1.52e-36	151.0	COG0457@1|root,COG0457@2|Bacteria	1089550.ATTH01000001_gene2496|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5705541_22	561180.BIFGAL_03604	2.284e-05	55.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,4CZ1G@85004|Bifidobacteriales	201174|Actinobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iNJ661.Rv3436c	GATase_6,SIS
TLS2_k127_5705541_10	264732.Moth_0624	6.059e-84	291.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,42FCG@68295|Thermoanaerobacterales	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_5705541_16	1380390.JIAT01000010_gene4756	4.543e-43	168.0	2AWIG@1|root,31NF3@2|Bacteria,2HR0R@201174|Actinobacteria,4CSUS@84995|Rubrobacteria	84995|Rubrobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_5705541_18	710687.KI912270_gene4061	5.751e-26	117.0	COG4464@1|root,COG4464@2|Bacteria	2|Bacteria	GM	protein tyrosine phosphatase activity	cpsB	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
TLS2_k127_5705541_7	469383.Cwoe_4683	3.805e-100	337.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CS51@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_5712716_2	710111.FraQA3DRAFT_3178	1.038e-38	156.0	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,4ESP8@85013|Frankiales	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS2_k127_5712716_3	649638.Trad_2317	1.262e-30	134.0	COG1295@1|root,COG1295@2|Bacteria	2|Bacteria	S	lipopolysaccharide transmembrane transporter activity	rbn	-	-	ko:K03466,ko:K07058	-	-	-	-	ko00000,ko03036	3.A.12	-	-	Virul_fac_BrkB
TLS2_k127_5712716_0	395963.Bind_0995	5.039e-52	187.0	COG0346@1|root,COG0346@2|Bacteria,1RIUN@1224|Proteobacteria,2U9CD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS2_k127_5712716_1	1380390.JIAT01000011_gene2542	5.029e-46	172.0	COG1595@1|root,COG1595@2|Bacteria,2HGII@201174|Actinobacteria,4CRQ5@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_5712716_4	644283.Micau_3648	4.638e-22	106.0	2E1T4@1|root,32X2Z@2|Bacteria,2H4V9@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5713642_12	40571.JOEA01000051_gene5882	5.02e-17	88.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4DYXD@85010|Pseudonocardiales	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_5713642_8	1122138.AQUZ01000019_gene8190	2.339e-94	328.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4DNJC@85009|Propionibacteriales	2|Bacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_5713642_7	469383.Cwoe_4727	9.591e-112	372.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4CRSZ@84995|Rubrobacteria	84995|Rubrobacteria	L	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
TLS2_k127_5713642_10	469383.Cwoe_3325	3.911e-40	170.0	COG2385@1|root,COG2385@2|Bacteria,2ID9T@201174|Actinobacteria,4CPMQ@84995|Rubrobacteria	84995|Rubrobacteria	D	Stage II sporulation protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
TLS2_k127_5713642_1	580327.Tthe_1947	1.307e-215	699.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
TLS2_k127_5713642_5	58123.JOFJ01000027_gene2790	3.636e-152	496.0	COG0531@1|root,COG0531@2|Bacteria,2H98W@201174|Actinobacteria,4EN0D@85012|Streptosporangiales	201174|Actinobacteria	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS2_k127_5713642_2	529709.PYCH_04440	5.294e-167	537.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
TLS2_k127_5713642_13	1448860.BBJO01000009_gene781	7.47e-10	64.0	COG0642@1|root,arCOG02376@1|root,arCOG02376@2157|Archaea,arCOG06408@2157|Archaea,2XWXH@28890|Euryarchaeota,23VAM@183963|Halobacteria	183963|Halobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,PAS_4
TLS2_k127_5713642_11	68199.JNZO01000013_gene3963	2.618e-29	129.0	COG1335@1|root,COG1335@2|Bacteria,2I8U4@201174|Actinobacteria	201174|Actinobacteria	Q	isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS2_k127_5713642_9	479434.Sthe_1775	2.951e-93	314.0	COG1136@1|root,COG1136@2|Bacteria,2G6B5@200795|Chloroflexi,27YCE@189775|Thermomicrobia	189775|Thermomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_5713642_15	926560.KE387023_gene2290	1.308e-05	52.0	COG2329@1|root,COG2329@2|Bacteria,1WNAU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS2_k127_5713642_4	479434.Sthe_1776	9.509e-155	525.0	COG0577@1|root,COG3127@1|root,COG0577@2|Bacteria,COG3127@2|Bacteria,2G6CK@200795|Chloroflexi,27Z42@189775|Thermomicrobia	189775|Thermomicrobia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
TLS2_k127_5713642_3	1386089.N865_16800	4.013e-164	531.0	COG0438@1|root,COG0438@2|Bacteria,2ICGI@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1,YHS
TLS2_k127_5713642_0	1380390.JIAT01000010_gene3879	0.0	1379.0	COG3957@1|root,COG3957@2|Bacteria,2GN27@201174|Actinobacteria,4CSGY@84995|Rubrobacteria	84995|Rubrobacteria	G	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
TLS2_k127_5713642_14	408672.NBCG_04038	1.078e-08	63.0	COG1359@1|root,COG1359@2|Bacteria,2IGI1@201174|Actinobacteria,4DR8A@85009|Propionibacteriales	201174|Actinobacteria	S	cellular response to starvation	-	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496	-	-	-	-	-	-	-	-	-	-	ABM
TLS2_k127_5713642_6	40571.JOEA01000050_gene7496	4.84e-122	404.0	COG5276@1|root,COG5276@2|Bacteria,2IBU7@201174|Actinobacteria,4EBUX@85010|Pseudonocardiales	201174|Actinobacteria	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD,PA
TLS2_k127_5720127_0	266117.Rxyl_1283	1.781e-200	676.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4CPEB@84995|Rubrobacteria	84995|Rubrobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS2_k127_5720127_1	42256.RradSPS_0504	8.249e-131	444.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4CPUU@84995|Rubrobacteria	84995|Rubrobacteria	M	glycosyl transferase, family 51	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS2_k127_5720127_2	479434.Sthe_0748	6.914e-48	185.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,2G6YQ@200795|Chloroflexi,27Y6P@189775|Thermomicrobia	189775|Thermomicrobia	H	MoaE protein	-	-	2.8.1.12	ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
TLS2_k127_5728654_0	760568.Desku_0398	1.093e-95	316.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,260QM@186807|Peptococcaceae	186801|Clostridia	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
TLS2_k127_5728654_1	469383.Cwoe_2648	1.333e-90	323.0	COG0740@1|root,COG0740@2|Bacteria,2GKNK@201174|Actinobacteria,4CPZA@84995|Rubrobacteria	84995|Rubrobacteria	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TLS2_k127_5728654_2	42256.RradSPS_1548	1.062e-68	252.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,4CPX5@84995|Rubrobacteria	84995|Rubrobacteria	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
TLS2_k127_5728654_4	1236902.ANAS01000036_gene2043	2.717e-31	143.0	COG0642@1|root,COG2205@2|Bacteria,2GK1J@201174|Actinobacteria,4EGGN@85012|Streptosporangiales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07654	ko02020,map02020	M00461	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_5728654_3	1179773.BN6_51710	2.797e-53	200.0	COG1295@1|root,COG1295@2|Bacteria,2GM6P@201174|Actinobacteria,4E0J5@85010|Pseudonocardiales	201174|Actinobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS2_k127_5735046_7	1121938.AUDY01000008_gene1119	2.275e-11	64.0	COG3342@1|root,COG3342@2|Bacteria,1TS8U@1239|Firmicutes,4HBYK@91061|Bacilli,3NFCT@45667|Halobacillus	91061|Bacilli	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
TLS2_k127_5735046_1	1051632.TPY_1473	4.379e-65	236.0	COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,249X0@186801|Clostridia	186801|Clostridia	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
TLS2_k127_5735046_3	663610.JQKO01000016_gene1606	4.736e-58	219.0	COG2706@1|root,COG2706@2|Bacteria,1NG69@1224|Proteobacteria,2UZGA@28211|Alphaproteobacteria,3NCBV@45404|Beijerinckiaceae	28211|Alphaproteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS2_k127_5735046_2	1380390.JIAT01000009_gene611	2.214e-63	224.0	COG1595@1|root,COG1595@2|Bacteria,2I9C1@201174|Actinobacteria,4CSI7@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
TLS2_k127_5735046_6	543632.JOJL01000002_gene8216	2.471e-14	77.0	COG5660@1|root,COG5660@2|Bacteria,2GQSP@201174|Actinobacteria	201174|Actinobacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_5735046_5	404589.Anae109_3621	8.584e-20	91.0	COG5660@1|root,COG5660@2|Bacteria,1NH4R@1224|Proteobacteria	1224|Proteobacteria	S	Transmembrane anti-sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_5735046_0	1122622.ATWJ01000001_gene2548	2.598e-104	349.0	COG2114@1|root,COG2114@2|Bacteria,2GJRI@201174|Actinobacteria,4FF4J@85021|Intrasporangiaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc
TLS2_k127_5737247_0	1380390.JIAT01000016_gene5545	3.431e-117	387.0	COG0306@1|root,COG0306@2|Bacteria,2GJHK@201174|Actinobacteria,4CQZ9@84995|Rubrobacteria	84995|Rubrobacteria	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
TLS2_k127_5737247_1	1380390.JIAT01000016_gene5544	7.354e-52	190.0	COG1392@1|root,COG1392@2|Bacteria,2GJME@201174|Actinobacteria,4CPW4@84995|Rubrobacteria	84995|Rubrobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
TLS2_k127_5737328_0	1380390.JIAT01000010_gene4409	2.339e-179	575.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4CPK9@84995|Rubrobacteria	84995|Rubrobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
TLS2_k127_5737328_1	469383.Cwoe_3622	5.618e-63	222.0	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,4CQ6T@84995|Rubrobacteria	84995|Rubrobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
TLS2_k127_5737328_6	1110697.NCAST_26_01350	2.035e-12	70.0	COG0291@1|root,COG0291@2|Bacteria,2GQZW@201174|Actinobacteria,4G421@85025|Nocardiaceae	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
TLS2_k127_5737328_3	1463821.JOGR01000009_gene1874	1.082e-37	148.0	COG0292@1|root,COG0292@2|Bacteria,2IHTN@201174|Actinobacteria,4EYQQ@85014|Glycomycetales	201174|Actinobacteria	J	Ribosomal protein L20	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
TLS2_k127_5737328_2	1509405.GV67_01860	1.286e-48	192.0	COG4427@1|root,COG4427@2|Bacteria,1R4EV@1224|Proteobacteria,2TRVP@28211|Alphaproteobacteria,4B83Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	DUF2332
TLS2_k127_5737328_4	469383.Cwoe_3618	7.306e-34	149.0	COG0566@1|root,COG0566@2|Bacteria,2GJI6@201174|Actinobacteria,4CPWM@84995|Rubrobacteria	84995|Rubrobacteria	J	tRNA rRNA methyltransferase, SpoU	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
TLS2_k127_5737328_5	227882.SAV_3520	1.381e-26	126.0	COG4319@1|root,COG4319@2|Bacteria,2INEA@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS2_k127_5744223_6	1380390.JIAT01000010_gene4534	1.672e-36	139.0	COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4CPH9@84995|Rubrobacteria	84995|Rubrobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS2_k127_5744223_3	469383.Cwoe_3514	6.586e-69	243.0	COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4CQ2J@84995|Rubrobacteria	84995|Rubrobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
TLS2_k127_5744223_2	42256.RradSPS_1408	2.547e-70	246.0	COG0020@1|root,COG0020@2|Bacteria,2GIXF@201174|Actinobacteria,4CPUS@84995|Rubrobacteria	84995|Rubrobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS2_k127_5744223_4	1380390.JIAT01000010_gene4537	1.042e-49	187.0	COG4589@1|root,COG4589@2|Bacteria,2GNWK@201174|Actinobacteria,4CQ05@84995|Rubrobacteria	84995|Rubrobacteria	S	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TLS2_k127_5744223_0	469383.Cwoe_3510	1.17e-101	342.0	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria,4CPQ0@84995|Rubrobacteria	84995|Rubrobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
TLS2_k127_5744223_5	929712.KI912613_gene3906	3.237e-45	187.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4CPEE@84995|Rubrobacteria	84995|Rubrobacteria	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
TLS2_k127_5744223_7	298655.KI912266_gene1825	1.486e-23	117.0	COG1434@1|root,COG1434@2|Bacteria,2IMCB@201174|Actinobacteria,4EWJI@85013|Frankiales	201174|Actinobacteria	S	Gram-negative-bacterium-type cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
TLS2_k127_5744223_1	1380390.JIAT01000010_gene4555	8.555e-100	332.0	COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,4CP63@84995|Rubrobacteria	84995|Rubrobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TLS2_k127_5745333_7	1146883.BLASA_0947	3.257e-40	156.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_4,Reg_prop,Y_Y_Y
TLS2_k127_5745333_4	1146883.BLASA_0946	1.078e-57	216.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria,4EVFA@85013|Frankiales	201174|Actinobacteria	K	Response regulator receiver	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
TLS2_k127_5745333_0	263358.VAB18032_22385	5.715e-304	953.0	COG2866@1|root,COG2866@2|Bacteria,2IAU2@201174|Actinobacteria,4DHB0@85008|Micromonosporales	201174|Actinobacteria	M	Carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,Peptidase_M14
TLS2_k127_5745333_8	469383.Cwoe_0140	2.889e-24	116.0	COG0216@1|root,COG0216@2|Bacteria,2I7Z4@201174|Actinobacteria,4CQHQ@84995|Rubrobacteria	84995|Rubrobacteria	J	RF-1 domain	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
TLS2_k127_5745333_3	1463909.KL585957_gene3165	1.167e-68	241.0	COG0647@1|root,COG0647@2|Bacteria,2GJG6@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the HAD-like hydrolase superfamily	-	-	-	ko:K02566	-	-	-	-	ko00000	-	-	-	Hydrolase_6,Hydrolase_like
TLS2_k127_5745333_9	1440774.Y900_027500	3.06e-23	104.0	COG0589@1|root,COG0589@2|Bacteria,2IQPQ@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS2_k127_5745333_10	502558.EGYY_21810	3.568e-21	98.0	COG0736@1|root,COG0736@2|Bacteria,2HT7V@201174|Actinobacteria,4CVSA@84998|Coriobacteriia	84998|Coriobacteriia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS2_k127_5745333_1	1283299.AUKG01000001_gene3201	1.354e-96	340.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2GJHB@201174|Actinobacteria,4CPXV@84995|Rubrobacteria	84995|Rubrobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
TLS2_k127_5745333_2	469383.Cwoe_1028	2.412e-72	259.0	COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4CP9P@84995|Rubrobacteria	84995|Rubrobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TLS2_k127_5745333_6	1380390.JIAT01000014_gene6079	1.061e-40	165.0	COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria,4CQTJ@84995|Rubrobacteria	84995|Rubrobacteria	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
TLS2_k127_5745333_5	1191523.MROS_0441	2.581e-42	160.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS2_k127_5745333_12	1173027.Mic7113_5718	0.0004483	53.0	COG0204@1|root,COG0204@2|Bacteria,1G1SN@1117|Cyanobacteria,1H99E@1150|Oscillatoriales	1117|Cyanobacteria	I	Acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS2_k127_5745333_11	1128421.JAGA01000002_gene1656	9.743e-07	60.0	COG0392@1|root,COG0392@2|Bacteria,2NQWM@2323|unclassified Bacteria	2|Bacteria	S	Lysylphosphatidylglycerol synthase TM region	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS2_k127_5755022_1	498848.TaqDRAFT_4395	5.345e-135	437.0	COG0235@1|root,COG0235@2|Bacteria,1WID4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Class II aldolase adducin family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
TLS2_k127_5755022_8	1380390.JIAT01000009_gene1192	3.946e-26	123.0	2FHCG@1|root,3496S@2|Bacteria,2H7A4@201174|Actinobacteria,4CQPX@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
TLS2_k127_5755022_5	290397.Adeh_0777	1.174e-41	171.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2WM7E@28221|Deltaproteobacteria,2YXN2@29|Myxococcales	28221|Deltaproteobacteria	GM	epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	3Beta_HSD,Epimerase
TLS2_k127_5755022_9	1134445.AJJM01000001_gene2710	3.698e-13	73.0	COG0662@1|root,COG0662@2|Bacteria,2IHNU@201174|Actinobacteria	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_5755022_2	469383.Cwoe_3964	1.657e-126	419.0	COG0665@1|root,COG0665@2|Bacteria,2H2ZZ@201174|Actinobacteria,4CTND@84995|Rubrobacteria	84995|Rubrobacteria	E	PFAM FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
TLS2_k127_5755022_10	1120950.KB892768_gene5231	7.79e-12	78.0	COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria,4DNYR@85009|Propionibacteriales	201174|Actinobacteria	GL	Phosphoglycerate mutase family	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
TLS2_k127_5755022_11	1089546.AQUI01000002_gene3721	7.681e-07	58.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,408P4@622450|Actinopolysporales	201174|Actinobacteria	KLT	PASTA	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_5755022_4	357808.RoseRS_2771	4.21e-80	290.0	COG1457@1|root,COG1457@2|Bacteria,2G9KC@200795|Chloroflexi,376PN@32061|Chloroflexia	32061|Chloroflexia	F	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	-	-	-	-	-	-	-	-	-	Transp_cyt_pur
TLS2_k127_5755022_0	211114.JOEF01000008_gene1237	2.153e-164	529.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4DXBU@85010|Pseudonocardiales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
TLS2_k127_5755022_3	469383.Cwoe_4898	7.683e-82	282.0	COG0559@1|root,COG0559@2|Bacteria,2GMAY@201174|Actinobacteria,4CPRG@84995|Rubrobacteria	84995|Rubrobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K11956	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	BPD_transp_2
TLS2_k127_5755022_7	469383.Cwoe_4897	1.5e-30	126.0	COG4177@1|root,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_5763380_10	103733.JNYO01000030_gene1476	2.264e-19	88.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4DXBU@85010|Pseudonocardiales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
TLS2_k127_5763380_3	469383.Cwoe_4898	3.571e-81	281.0	COG0559@1|root,COG0559@2|Bacteria,2GMAY@201174|Actinobacteria,4CPRG@84995|Rubrobacteria	84995|Rubrobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K11956	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	BPD_transp_2
TLS2_k127_5763380_4	469383.Cwoe_4897	1.266e-80	293.0	COG4177@1|root,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS2_k127_5763380_1	469383.Cwoe_3968	8.525e-93	329.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4CPJW@84995|Rubrobacteria	84995|Rubrobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS2_k127_5763380_7	582515.KR51_00003440	2.071e-76	271.0	COG0410@1|root,COG0410@2|Bacteria,1G1TN@1117|Cyanobacteria	1117|Cyanobacteria	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01996,ko:K11958	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	ABC_tran
TLS2_k127_5763380_2	469383.Cwoe_4899	5.443e-86	301.0	COG0683@1|root,COG0683@2|Bacteria,2GM00@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Extracellular ligand-binding receptor	livK	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS2_k127_5763380_0	469371.Tbis_2951	1.995e-100	340.0	COG0384@1|root,COG0384@2|Bacteria,2GM1W@201174|Actinobacteria,4DZTV@85010|Pseudonocardiales	201174|Actinobacteria	S	Phenazine biosynthesis PhzC PhzF protein	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
TLS2_k127_5763380_5	543632.JOJL01000035_gene5070	3.858e-79	273.0	COG5012@1|root,COG5012@2|Bacteria,2I2EI@201174|Actinobacteria	201174|Actinobacteria	S	B12 binding domain	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
TLS2_k127_5763380_8	543632.JOJL01000035_gene5069	2.895e-21	96.0	COG2155@1|root,COG2155@2|Bacteria,2H8ZK@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF378)	-	-	-	-	-	-	-	-	-	-	-	-	DUF378
TLS2_k127_5763380_6	1068978.AMETH_2187	3.689e-78	279.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,4E2AT@85010|Pseudonocardiales	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA,TspO_MBR
TLS2_k127_5763380_9	1155718.KB891903_gene1570	1.559e-19	94.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_5769836_8	1123024.AUII01000011_gene4461	2.488e-41	168.0	COG0069@1|root,COG0069@2|Bacteria,2GME2@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_9,Glu_syn_central,Glu_synthase
TLS2_k127_5769836_5	1123024.AUII01000011_gene4460	2.792e-113	379.0	COG2218@1|root,COG2218@2|Bacteria,2I686@201174|Actinobacteria	201174|Actinobacteria	C	Glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	GXGXG
TLS2_k127_5769836_3	1123023.JIAI01000007_gene1968	1.037e-136	441.0	COG0034@1|root,COG0034@2|Bacteria,2I3P1@201174|Actinobacteria	201174|Actinobacteria	F	Glutamine amidotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	GATase_6
TLS2_k127_5769836_1	1123023.JIAI01000007_gene1967	8.146e-157	511.0	COG0174@1|root,COG0174@2|Bacteria,2I8RB@201174|Actinobacteria	201174|Actinobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
TLS2_k127_5769836_7	1313172.YM304_31960	1.434e-55	209.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,2H3SH@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS2_k127_5769836_0	314231.FP2506_16744	6.015e-193	616.0	COG0004@1|root,COG0004@2|Bacteria,1MX44@1224|Proteobacteria,2TR55@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0004 Ammonia permease	amt	-	-	-	-	-	-	-	-	-	-	-	Ammonium_transp
TLS2_k127_5769836_6	1123023.JIAI01000007_gene1954	5.179e-61	227.0	COG1414@1|root,COG1414@2|Bacteria,2GM23@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS2_k127_5769836_2	1123023.JIAI01000007_gene1953	1.133e-150	491.0	COG0665@1|root,COG0665@2|Bacteria	2|Bacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS2_k127_5769836_4	1429046.RR21198_2081	2.161e-116	376.0	COG0262@1|root,COG0262@2|Bacteria,2GK32@201174|Actinobacteria,4FX6U@85025|Nocardiaceae	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS2_k127_5769836_9	146922.JOFU01000021_gene2406	3.726e-05	47.0	COG2154@1|root,COG2154@2|Bacteria,2IHZE@201174|Actinobacteria	201174|Actinobacteria	H	dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
TLS2_k127_5774556_4	543728.Vapar_1354	1.035e-32	129.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,2VRGS@28216|Betaproteobacteria,4AFNW@80864|Comamonadaceae	28216|Betaproteobacteria	S	Appr-1'-p processing enzyme	ymdB	-	-	-	-	-	-	-	-	-	-	-	Macro
TLS2_k127_5774556_0	266117.Rxyl_3075	1.987e-156	507.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria	201174|Actinobacteria	E	dehydrogenase	-	-	-	ko:K18369	ko00640,map00640	-	R10703	RC00545	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
TLS2_k127_5774556_2	251221.35214832	3.261e-97	327.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	CPSase_L_D2,Dala_Dala_lig_C,RimK
TLS2_k127_5774556_3	1254432.SCE1572_34415	7.843e-75	263.0	COG1086@1|root,COG1215@1|root,COG1086@2|Bacteria,COG1215@2|Bacteria,1R988@1224|Proteobacteria,42QGX@68525|delta/epsilon subdivisions,2WJPU@28221|Deltaproteobacteria,2YV0M@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_5774556_1	269799.Gmet_2187	7.019e-136	444.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,42PB7@68525|delta/epsilon subdivisions,2WJX5@28221|Deltaproteobacteria,43U6C@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Mycolic acid cyclopropane synthetase	cfa1	-	2.1.1.317,2.1.1.79	ko:K00574,ko:K20238	-	-	-	-	ko00000,ko01000	-	-	iAF987.Gmet_2187	CMAS
TLS2_k127_5777580_5	479434.Sthe_2323	7.826e-13	70.0	COG1917@1|root,COG1917@2|Bacteria,2G9GF@200795|Chloroflexi,27ZAK@189775|Thermomicrobia	189775|Thermomicrobia	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_5777580_4	298655.KI912266_gene1566	9.04e-24	113.0	COG1503@1|root,COG1503@2|Bacteria,2IFQH@201174|Actinobacteria,4ET50@85013|Frankiales	201174|Actinobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5777580_0	479434.Sthe_1703	3.234e-119	413.0	COG1193@1|root,COG1193@2|Bacteria,2G5R8@200795|Chloroflexi,27XIK@189775|Thermomicrobia	189775|Thermomicrobia	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
TLS2_k127_5777580_1	1089545.KB913037_gene8886	1.603e-45	186.0	COG0612@1|root,COG0612@2|Bacteria,2GNAW@201174|Actinobacteria,4E7XJ@85010|Pseudonocardiales	201174|Actinobacteria	S	Peptidase, M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16_C
TLS2_k127_5777580_2	1211114.ALIP01000140_gene2317	6.338e-37	139.0	2DJKR@1|root,32YT5@2|Bacteria,1NACC@1224|Proteobacteria,1ST3I@1236|Gammaproteobacteria,1X8AD@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5777580_3	298653.Franean1_6488	8.178e-29	119.0	COG1970@1|root,COG1970@2|Bacteria,2IQDN@201174|Actinobacteria,4ET97@85013|Frankiales	201174|Actinobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
TLS2_k127_5777580_6	1229172.JQFA01000002_gene2577	4.18e-07	53.0	COG3367@1|root,COG3367@2|Bacteria,1GBZ5@1117|Cyanobacteria	1117|Cyanobacteria	S	COGs COG3367 conserved	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5785294_2	383372.Rcas_3557	3.018e-62	227.0	COG0843@1|root,COG0843@2|Bacteria,2G5XS@200795|Chloroflexi,3750X@32061|Chloroflexia	32061|Chloroflexia	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS2_k127_5785294_4	1382356.JQMP01000004_gene54	1.056e-41	169.0	COG1622@1|root,COG1622@2|Bacteria,2G6C0@200795|Chloroflexi,27XKX@189775|Thermomicrobia	189775|Thermomicrobia	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
TLS2_k127_5785294_1	469383.Cwoe_5009	1.678e-91	310.0	COG1052@1|root,COG1052@2|Bacteria,2I2RK@201174|Actinobacteria,4CPZ9@84995|Rubrobacteria	84995|Rubrobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS2_k127_5785294_0	525904.Tter_0160	1.618e-181	579.0	COG0277@1|root,COG0277@2|Bacteria,2NP2P@2323|unclassified Bacteria	2|Bacteria	C	FAD linked oxidases, C-terminal domain	glcD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750	FAD-oxidase_C,FAD_binding_4
TLS2_k127_5785294_3	1137271.AZUM01000004_gene4210	9.206e-42	165.0	COG0277@1|root,COG0277@2|Bacteria,2H3K3@201174|Actinobacteria,4E18A@85010|Pseudonocardiales	201174|Actinobacteria	C	overlaps another CDS with the same product name	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS2_k127_5789280_1	448385.sce5871	2.621e-157	505.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,2YX1T@29|Myxococcales	28221|Deltaproteobacteria	H	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TLS2_k127_5789280_3	1380390.JIAT01000009_gene332	3.419e-43	180.0	COG1316@1|root,COG1316@2|Bacteria,2HJ7K@201174|Actinobacteria,4CPJT@84995|Rubrobacteria	84995|Rubrobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
TLS2_k127_5789280_2	1122611.KB903944_gene1134	5.082e-157	507.0	COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	tuaD	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd,UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS2_k127_5789280_4	269800.Tfu_2143	1.503e-39	171.0	COG1208@1|root,COG1208@2|Bacteria,2GMX6@201174|Actinobacteria,4ENQR@85012|Streptosporangiales	201174|Actinobacteria	JM	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
TLS2_k127_5789280_6	469383.Cwoe_0298	9.195e-33	142.0	COG0662@1|root,COG0662@2|Bacteria,2GXUC@201174|Actinobacteria,4CT1G@84995|Rubrobacteria	84995|Rubrobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	MannoseP_isomer
TLS2_k127_5789280_0	926569.ANT_16170	1.714e-187	596.0	COG0499@1|root,COG0499@2|Bacteria,2G5X8@200795|Chloroflexi	200795|Chloroflexi	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS2_k127_5789280_5	644966.Tmar_2110	1.441e-38	154.0	COG0182@1|root,COG0182@2|Bacteria,1TPDK@1239|Firmicutes,249C5@186801|Clostridia,3WCG0@538999|Clostridiales incertae sedis	186801|Clostridia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
TLS2_k127_5792742_1	1255043.TVNIR_0040	1.083e-56	205.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,1RPJH@1236|Gammaproteobacteria,1WWU7@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
TLS2_k127_5792742_2	479434.Sthe_3331	5.595e-34	135.0	2BVHN@1|root,32SWN@2|Bacteria,2G8ZV@200795|Chloroflexi	200795|Chloroflexi	S	Pfam:DUF385	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS2_k127_5792742_0	469383.Cwoe_3606	3.724e-145	473.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CP98@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS2_k127_5794630_0	1123251.ATWM01000003_gene960	0.0	1114.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4FFQQ@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS2_k127_5794630_4	1111131.HMPREF1255_0533	2.791e-69	244.0	COG1806@1|root,COG1806@2|Bacteria,2IDD1@201174|Actinobacteria	201174|Actinobacteria	S	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
TLS2_k127_5794630_2	1089553.Tph_c05770	3.1e-110	386.0	COG0751@1|root,COG0751@2|Bacteria,1TNZ7@1239|Firmicutes,248RS@186801|Clostridia,42FPG@68295|Thermoanaerobacterales	186801|Clostridia	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
TLS2_k127_5794630_1	1121468.AUBR01000082_gene842	3.605e-126	411.0	COG0752@1|root,COG0752@2|Bacteria,1TPW8@1239|Firmicutes,24AU0@186801|Clostridia,42FN5@68295|Thermoanaerobacterales	186801|Clostridia	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
TLS2_k127_5794630_6	469383.Cwoe_3103	1.224e-48	184.0	COG1381@1|root,COG1381@2|Bacteria,2GK81@201174|Actinobacteria,4CQNS@84995|Rubrobacteria	84995|Rubrobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
TLS2_k127_5794630_7	469383.Cwoe_3102	5.169e-23	101.0	COG0695@1|root,COG0695@2|Bacteria,2HPAH@201174|Actinobacteria,4CQNW@84995|Rubrobacteria	84995|Rubrobacteria	O	Glutaredoxin	-	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
TLS2_k127_5794630_5	469383.Cwoe_3094	1.498e-68	242.0	COG0266@1|root,COG0266@2|Bacteria,2GJNT@201174|Actinobacteria,4CPMX@84995|Rubrobacteria	84995|Rubrobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_5794630_3	1121346.KB899830_gene681	3.793e-85	290.0	COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,4H9NP@91061|Bacilli,26QE9@186822|Paenibacillaceae	91061|Bacilli	F	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate	pdp	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
TLS2_k127_5831964_4	1502851.FG93_04504	7.621e-16	82.0	COG0110@1|root,COG0110@2|Bacteria,1MZV9@1224|Proteobacteria,2U5TI@28211|Alphaproteobacteria,3K6DR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
TLS2_k127_5831964_2	379066.GAU_0341	4.898e-98	334.0	COG0399@1|root,COG0399@2|Bacteria,1ZT81@142182|Gemmatimonadetes	2|Bacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_5831964_1	1487953.JMKF01000047_gene2122	6.173e-125	407.0	28IYZ@1|root,2Z8WJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS2_k127_5831964_3	357808.RoseRS_2391	2.879e-94	332.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K20444	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Acyltransferase,MMPL,Methyltransf_13,Methyltransf_14,Methyltransf_23,Methyltransf_31
TLS2_k127_5831964_0	383372.Rcas_3091	2.757e-126	413.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.294,2.1.1.79,2.7.1.181	ko:K00574,ko:K18827	-	-	R10657,R10658	RC00002,RC00003,RC00078,RC03220	ko00000,ko01000,ko01005	-	-	-	MethyTransf_Reg,Methyltransf_14,Methyltransf_23,Methyltransf_25,Methyltransf_31
TLS2_k127_5873727_0	370438.PTH_0241	2.18e-111	362.0	COG2046@1|root,COG2046@2|Bacteria,1TR4C@1239|Firmicutes,249ZJ@186801|Clostridia,26026@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
TLS2_k127_5873727_1	644282.Deba_2097	2.478e-61	227.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42NYX@68525|delta/epsilon subdivisions,2WJV8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	arnC	-	2.4.2.53	ko:K10012,ko:K20534	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8,4.D.2.1.9	GT2	-	Glycos_transf_2
TLS2_k127_5873727_3	526225.Gobs_0233	1.82e-08	67.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_5873727_2	399739.Pmen_4289	2.491e-14	74.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,1RP7G@1236|Gammaproteobacteria,1YE6F@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_5881948_0	1380390.JIAT01000010_gene4380	5.594e-131	420.0	COG0596@1|root,COG0596@2|Bacteria,2GK79@201174|Actinobacteria,4CS3C@84995|Rubrobacteria	84995|Rubrobacteria	S	Epoxide hydrolase N terminus	-	-	-	-	-	-	-	-	-	-	-	-	EHN
TLS2_k127_5881948_1	1464048.JNZS01000006_gene4102	3.178e-88	301.0	COG0526@1|root,COG0526@2|Bacteria,2GKDT@201174|Actinobacteria,4DI6I@85008|Micromonosporales	201174|Actinobacteria	CO	AhpC/TSA family	dipZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD
TLS2_k127_5881948_3	1150864.MILUP08_45301	2.663e-60	218.0	COG0526@1|root,COG0526@2|Bacteria,2GKDT@201174|Actinobacteria,4DI6I@85008|Micromonosporales	201174|Actinobacteria	CO	AhpC/TSA family	dipZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD
TLS2_k127_5881948_2	1123371.ATXH01000011_gene104	2.195e-63	225.0	COG0501@1|root,COG0501@2|Bacteria,2GH8X@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS2_k127_5889872_3	1869.MB27_08080	0.0004207	45.0	COG2513@1|root,COG2513@2|Bacteria,2GMQ4@201174|Actinobacteria,4DEP9@85008|Micromonosporales	201174|Actinobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
TLS2_k127_5889872_0	1230476.C207_02861	2.828e-93	326.0	COG2114@1|root,COG2114@2|Bacteria,1QWNC@1224|Proteobacteria,2TRQB@28211|Alphaproteobacteria,3JQN6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1,4.6.1.2	ko:K01768,ko:K01769	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,Guanylate_cyc,HAMP
TLS2_k127_5889872_1	1089553.Tph_c04850	1.142e-52	212.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,42F3M@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM ATP-binding region, ATPase domain protein	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
TLS2_k127_5889872_2	1048339.KB913029_gene741	2.452e-06	51.0	COG1595@1|root,COG1595@2|Bacteria,2IG3F@201174|Actinobacteria,4EV2D@85013|Frankiales	201174|Actinobacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2
TLS2_k127_5902396_0	1370121.AUWS01000057_gene3712	5.643e-132	434.0	COG1231@1|root,COG1231@2|Bacteria,2GK23@201174|Actinobacteria,236IP@1762|Mycobacteriaceae	201174|Actinobacteria	E	Flavin containing amine oxidoreductase	puo	-	1.4.3.10,1.4.3.4	ko:K00274,ko:K03343	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R01151,R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS2_k127_5902396_3	1206101.AZXC01000007_gene2590	2.581e-103	368.0	COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	1.14.15.7	ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
TLS2_k127_5902396_2	1380391.JIAS01000011_gene5426	4.57e-104	350.0	COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2TTX8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS2_k127_5902396_6	416348.Hlac_2347	4.313e-17	92.0	COG0824@1|root,arCOG01137@2157|Archaea,2XZ99@28890|Euryarchaeota,23WUB@183963|Halobacteria	183963|Halobacteria	S	Thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
TLS2_k127_5902396_5	1380394.JADL01000010_gene4393	1.249e-78	291.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2JV15@204441|Rhodospirillales	204441|Rhodospirillales	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
TLS2_k127_5902396_1	981369.JQMJ01000004_gene3845	4.792e-114	381.0	COG0687@1|root,COG0687@2|Bacteria,2HPJT@201174|Actinobacteria,2NKQJ@228398|Streptacidiphilus	201174|Actinobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
TLS2_k127_5902396_4	1380391.JIAS01000013_gene3517	2.536e-100	337.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2TSFD@28211|Alphaproteobacteria,2JQTE@204441|Rhodospirillales	204441|Rhodospirillales	E	Putrescine transport system permease	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS2_k127_5902396_7	710687.KI912270_gene393	3.669e-13	81.0	COG1177@1|root,COG1177@2|Bacteria,2HXTT@201174|Actinobacteria,237JY@1762|Mycobacteriaceae	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS2_k127_5902543_3	309801.trd_0179	4.332e-68	241.0	COG0123@1|root,COG0123@2|Bacteria,2G5X3@200795|Chloroflexi,27XTE@189775|Thermomicrobia	189775|Thermomicrobia	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TLS2_k127_5902543_7	591158.SSMG_02727	0.0004706	52.0	COG0761@1|root,COG0775@1|root,COG0761@2|Bacteria,COG0775@2|Bacteria,2GIZ7@201174|Actinobacteria	201174|Actinobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB,PNP_UDP_1
TLS2_k127_5902543_1	575540.Isop_2284	8.445e-95	334.0	COG0535@1|root,COG0535@2|Bacteria,2IWZK@203682|Planctomycetes	203682|Planctomycetes	S	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_12,Fer4_14,Radical_SAM
TLS2_k127_5902543_5	1150626.PHAMO_10277	5.921e-57	226.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,2TTTU@28211|Alphaproteobacteria,2JPSX@204441|Rhodospirillales	204441|Rhodospirillales	M	NmrA-like family	dfrA	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
TLS2_k127_5902543_0	1223523.H340_25882	2.637e-206	660.0	COG1657@1|root,COG1657@2|Bacteria,2GM7H@201174|Actinobacteria	201174|Actinobacteria	I	Squalene--hopene cyclase	shc	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
TLS2_k127_5902543_2	1146883.BLASA_0213	3.653e-77	280.0	COG1232@1|root,COG1232@2|Bacteria,2I2Z5@201174|Actinobacteria,4ERME@85013|Frankiales	201174|Actinobacteria	H	PFAM amine oxidase	hopC	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS2_k127_5902543_4	1896.JOAU01000014_gene1604	4.556e-62	226.0	COG1562@1|root,COG1562@2|Bacteria,2GJN2@201174|Actinobacteria	201174|Actinobacteria	I	phytoene synthase	crtB	GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
TLS2_k127_5902543_6	1500894.JQNN01000001_gene1127	7.437e-05	47.0	COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,2VIZC@28216|Betaproteobacteria,473HF@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Squalene/phytoene synthase	hpnC	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
TLS2_k127_59521_0	469383.Cwoe_2829	1.949e-134	436.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4CPVB@84995|Rubrobacteria	84995|Rubrobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
TLS2_k127_59521_2	469383.Cwoe_1802	3.758e-61	226.0	COG0265@1|root,COG1286@1|root,COG0265@2|Bacteria,COG1286@2|Bacteria,2GJ92@201174|Actinobacteria,4CP5Z@84995|Rubrobacteria	84995|Rubrobacteria	O	Colicin V production protein	-	-	-	-	-	-	-	-	-	-	-	-	Colicin_V,Trypsin_2
TLS2_k127_59521_3	1380390.JIAT01000016_gene5649	5.126e-38	150.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4CQW7@84995|Rubrobacteria	84995|Rubrobacteria	L	Helix-hairpin-helix motif	-	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
TLS2_k127_59521_1	1283299.AUKG01000004_gene1238	6.641e-63	243.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4CPP2@84995|Rubrobacteria	84995|Rubrobacteria	S	Competence protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
TLS2_k127_5986763_3	926554.KI912640_gene1276	1.02e-95	325.0	COG2133@1|root,COG2133@2|Bacteria,1WJQY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS2_k127_5986763_5	1121423.JONT01000014_gene1251	2.403e-88	320.0	COG0460@1|root,COG0460@2|Bacteria,1TQ2H@1239|Firmicutes,248MU@186801|Clostridia,2600D@186807|Peptococcaceae	186801|Clostridia	E	PFAM Homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
TLS2_k127_5986763_6	1121946.AUAX01000009_gene4298	2.976e-86	304.0	COG0498@1|root,COG0498@2|Bacteria,2GJ5F@201174|Actinobacteria,4D98N@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_5986763_9	222534.KB893751_gene4138	1.2e-40	171.0	COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria,4ESFG@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS2_k127_5986763_8	469383.Cwoe_4474	3.25e-73	268.0	COG2897@1|root,COG2897@2|Bacteria,2GMDR@201174|Actinobacteria	201174|Actinobacteria	P	sulfurtransferase	sseA2	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS2_k127_5986763_4	1047013.AQSP01000144_gene894	7.29e-92	333.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_C,Sulfatase
TLS2_k127_5986763_12	1123023.JIAI01000007_gene1754	2.409e-17	86.0	COG3324@1|root,COG3324@2|Bacteria,2IKNU@201174|Actinobacteria,4E4CK@85010|Pseudonocardiales	201174|Actinobacteria	E	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5986763_7	1283299.AUKG01000001_gene2216	6.151e-77	268.0	COG2423@1|root,COG2423@2|Bacteria,2GJ0U@201174|Actinobacteria,4CPC0@84995|Rubrobacteria	84995|Rubrobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	OCD_Mu_crystall
TLS2_k127_5986763_2	479434.Sthe_0007	6.774e-111	366.0	COG0119@1|root,COG0119@2|Bacteria,2G7M0@200795|Chloroflexi,27YV0@189775|Thermomicrobia	189775|Thermomicrobia	E	HMGL-like	-	-	4.1.3.46	ko:K18314	-	-	R10674	RC00502,RC01205	ko00000,ko01000	-	-	-	HMGL-like
TLS2_k127_5986763_11	223184.AS25_00245	2.516e-28	124.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,1W7KF@1268|Micrococcaceae	201174|Actinobacteria	O	Belongs to the ClpA ClpB family	clpC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
TLS2_k127_5986763_13	345341.KUTG_07350	9.765e-12	74.0	2B36U@1|root,31VUU@2|Bacteria,2GW94@201174|Actinobacteria,4E6YV@85010|Pseudonocardiales	201174|Actinobacteria	S	ClpX C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-C4_ClpX
TLS2_k127_5986763_0	526227.Mesil_1872	3.708e-252	788.0	COG1012@1|root,COG1012@2|Bacteria,1WJFH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Aldehyde dehydrogenase family	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_5986763_1	1173024.KI912149_gene6331	6.389e-138	448.0	COG0265@1|root,COG0265@2|Bacteria,1G70N@1117|Cyanobacteria	1117|Cyanobacteria	O	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_5986763_10	644283.Micau_1142	1.268e-33	134.0	COG0662@1|root,COG0662@2|Bacteria,2II1B@201174|Actinobacteria,4DDJ1@85008|Micromonosporales	201174|Actinobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_6030077_1	469383.Cwoe_5908	3.699e-98	327.0	COG0438@1|root,COG0438@2|Bacteria,2ICGI@201174|Actinobacteria,4CPFR@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
TLS2_k127_6030077_3	224308.BSU04720	1.232e-19	93.0	COG2172@1|root,COG2172@2|Bacteria,1V1IA@1239|Firmicutes,4HM6Z@91061|Bacilli,1ZQQZ@1386|Bacillus	91061|Bacilli	F	Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)	rsbW	GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
TLS2_k127_6030077_0	1380390.JIAT01000009_gene1675	6.674e-115	381.0	COG2189@1|root,COG2189@2|Bacteria,2I8FH@201174|Actinobacteria,4CSJ2@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
TLS2_k127_6030077_2	469383.Cwoe_5907	5.839e-36	142.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4CPH3@84995|Rubrobacteria	84995|Rubrobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS2_k127_6045209_1	469383.Cwoe_4628	4.103e-86	301.0	COG0472@1|root,COG0472@2|Bacteria,2GIT7@201174|Actinobacteria,4CQIN@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferase, family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
TLS2_k127_6045209_0	383372.Rcas_3083	1.025e-138	454.0	COG0677@1|root,COG0677@2|Bacteria,2G5PP@200795|Chloroflexi,3756K@32061|Chloroflexia	32061|Chloroflexia	M	PFAM UDP-glucose GDP-mannose dehydrogenase	-	-	1.1.1.136	ko:K13015	ko00520,map00520	-	R00421	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS2_k127_6045209_5	222984.JNCS01000003_gene3025	1.579e-12	78.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,23STH@183963|Halobacteria	183963|Halobacteria	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.2,5.1.3.25	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	M00361,M00362,M00632	R00291,R02984,R10279	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS2_k127_6045209_4	469383.Cwoe_1547	9.555e-20	104.0	COG0451@1|root,COG0451@2|Bacteria,2GK8K@201174|Actinobacteria	201174|Actinobacteria	GM	Epimerase dehydratase	-	-	5.1.3.2,5.1.3.25	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	M00361,M00362,M00632	R00291,R02984,R10279	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS2_k127_6045209_3	1305732.JAGG01000001_gene2098	2.083e-43	180.0	COG1086@1|root,COG1086@2|Bacteria,2GIXM@201174|Actinobacteria,4FMJP@85023|Microbacteriaceae	201174|Actinobacteria	M	CoA-binding domain	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding_3,Polysacc_synt_2
TLS2_k127_6045209_2	1499684.CCNP01000018_gene554	5.001e-76	262.0	COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,248FV@186801|Clostridia,36DZ9@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
TLS2_k127_6052058_13	269797.Mbar_A1140	0.0002837	53.0	COG0726@1|root,arCOG02877@2157|Archaea,2XT5E@28890|Euryarchaeota,2NABM@224756|Methanomicrobia	224756|Methanomicrobia	G	4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6052058_8	644966.Tmar_0646	1.189e-45	181.0	COG0438@1|root,COG0438@2|Bacteria,1V0G0@1239|Firmicutes,25BFP@186801|Clostridia	186801|Clostridia	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_6052058_3	755732.Fluta_2190	4.718e-63	225.0	COG2120@1|root,COG2120@2|Bacteria,4NN16@976|Bacteroidetes	976|Bacteroidetes	S	PFAM N-acetylglucosaminyl phosphatidylinositol deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS2_k127_6052058_2	66429.JOFL01000003_gene3418	9.235e-64	233.0	COG1296@1|root,COG1296@2|Bacteria,2IJ35@201174|Actinobacteria	201174|Actinobacteria	E	AzlC protein	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
TLS2_k127_6052058_4	1236902.ANAS01000009_gene2594	2.47e-58	214.0	COG1108@1|root,COG1108@2|Bacteria,2GJ7H@201174|Actinobacteria,4EI6R@85012|Streptosporangiales	201174|Actinobacteria	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
TLS2_k127_6052058_7	1386089.N865_16990	1.15e-48	196.0	COG1121@1|root,COG1121@2|Bacteria,2GP3A@201174|Actinobacteria,4FFIB@85021|Intrasporangiaceae	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	mntB	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
TLS2_k127_6052058_5	512565.AMIS_12060	7.102e-56	208.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,4D9QD@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	scbA	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
TLS2_k127_6052058_10	1050202.KB913024_gene2334	6.469e-30	125.0	COG0735@1|root,COG0735@2|Bacteria,2IKS3@201174|Actinobacteria,4091W@622450|Actinopolysporales	201174|Actinobacteria	P	Ferric uptake regulator family	furB	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS2_k127_6052058_12	1123274.KB899414_gene3754	4.59e-09	70.0	COG2885@1|root,COG2885@2|Bacteria,2J5KD@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,CHU_C,FlgD_ig,OmpA
TLS2_k127_6052058_0	469383.Cwoe_5493	6.103e-111	370.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4CPAJ@84995|Rubrobacteria	84995|Rubrobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS2_k127_6052058_6	1380390.JIAT01000015_gene5716	2.432e-51	189.0	COG0586@1|root,COG0586@2|Bacteria,2GN43@201174|Actinobacteria	201174|Actinobacteria	S	Pfam SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS2_k127_6052058_9	469383.Cwoe_1653	1.032e-31	142.0	COG5017@1|root,COG5017@2|Bacteria,2HPVP@201174|Actinobacteria,4CRAA@84995|Rubrobacteria	84995|Rubrobacteria	S	D-glucuronyl C5-epimerase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	C5-epim_C
TLS2_k127_6052058_1	760568.Desku_1548	3.49e-106	351.0	COG1060@1|root,COG1060@2|Bacteria,1TRHG@1239|Firmicutes,247Z2@186801|Clostridia,2609W@186807|Peptococcaceae	186801|Clostridia	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1,2.5.1.77	ko:K11779,ko:K11784	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396	RC01381,RC02329,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
TLS2_k127_6054215_6	861450.HMPREF0080_01899	5.794e-12	68.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,4H274@909932|Negativicutes	909932|Negativicutes	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS2_k127_6054215_0	717605.Theco_1935	1.979e-136	447.0	COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,4H9NP@91061|Bacilli,26QE9@186822|Paenibacillaceae	91061|Bacilli	F	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate	pdp	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
TLS2_k127_6054215_2	349161.Dred_1100	8.525e-131	428.0	COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,260HR@186807|Peptococcaceae	186801|Clostridia	G	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
TLS2_k127_6054215_1	1120934.KB894409_gene6411	1.724e-135	449.0	COG0686@1|root,COG0686@2|Bacteria,2GJ6G@201174|Actinobacteria,4DYAJ@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the AlaDH PNT family	ald	GO:0000286,GO:0001666,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009628,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030312,GO:0036293,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050896,GO:0055114,GO:0070482,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TLS2_k127_6054215_4	429009.Adeg_0447	6.323e-30	126.0	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia,42GHZ@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM NUDIX hydrolase	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TLS2_k127_6054215_3	469383.Cwoe_3087	1.133e-97	331.0	COG2195@1|root,COG2195@2|Bacteria,2HPTW@201174|Actinobacteria,4CR7V@84995|Rubrobacteria	84995|Rubrobacteria	E	Peptidase dimerisation domain	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS2_k127_6054215_5	485916.Dtox_0054	9.099e-14	71.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,260W1@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
TLS2_k127_6055191_0	469383.Cwoe_2843	1.134e-114	380.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,4CP6R@84995|Rubrobacteria	84995|Rubrobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS2_k127_6055191_1	469383.Cwoe_2842	7.057e-112	371.0	COG1420@1|root,COG1420@2|Bacteria,2GKF5@201174|Actinobacteria,4CP6H@84995|Rubrobacteria	84995|Rubrobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
TLS2_k127_6055191_3	1479238.JQMZ01000001_gene1663	4.603e-18	93.0	COG3548@1|root,COG3548@2|Bacteria,1RE3H@1224|Proteobacteria,2V6IX@28211|Alphaproteobacteria,43XF1@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
TLS2_k127_6055191_2	478741.JAFS01000002_gene821	6.652e-52	192.0	COG0635@1|root,COG0635@2|Bacteria,46STN@74201|Verrucomicrobia,37FV5@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
TLS2_k127_6083236_1	526225.Gobs_1938	1.317e-42	165.0	COG0665@1|root,COG0665@2|Bacteria,2GNAE@201174|Actinobacteria,4EVK9@85013|Frankiales	201174|Actinobacteria	E	PFAM FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
TLS2_k127_6083236_2	1205910.B005_2783	2.971e-41	159.0	COG1309@1|root,COG1309@2|Bacteria,2GMZ1@201174|Actinobacteria,4EMA5@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_6083236_4	1169161.KB897741_gene1931	6.662e-33	130.0	2EHQF@1|root,33BG7@2|Bacteria,2IRDG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6083236_6	523841.HFX_1646	2.349e-12	80.0	arCOG03006@1|root,arCOG03006@2157|Archaea,2XYR1@28890|Euryarchaeota,23WX6@183963|Halobacteria	183963|Halobacteria	S	COG0662 Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_6083236_0	1382306.JNIM01000001_gene2570	1.61e-255	795.0	COG4799@1|root,COG4799@2|Bacteria,2G61R@200795|Chloroflexi	200795|Chloroflexi	I	PFAM carboxyl transferase	-	-	2.1.3.15,6.4.1.3,6.4.1.4	ko:K01969,ko:K15052	ko00280,ko00720,ko01100,ko01200,map00280,map00720,map01100,map01200	M00036,M00376	R01859,R04138	RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS2_k127_6083236_3	207559.Dde_1416	8.729e-35	147.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2WMD9@28221|Deltaproteobacteria,2M8AQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Hemolysin-type calcium-binding region	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,HCBP_related,He_PIG,HemolysinCabind,Peptidase_M91,VWA,VWA_2
TLS2_k127_6090666_1	1236973.JCM9157_1344	2.472e-80	284.0	COG5276@1|root,COG5276@2|Bacteria,1UUVN@1239|Firmicutes,4HBJX@91061|Bacilli,1ZE6M@1386|Bacillus	91061|Bacilli	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_6095661_18	134676.ACPL_2068	1.603e-09	70.0	2EGD2@1|root,33A4V@2|Bacteria,2IT2B@201174|Actinobacteria,4DEY9@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
TLS2_k127_6095661_6	1380390.JIAT01000009_gene1498	1.215e-54	200.0	COG1714@1|root,COG1714@2|Bacteria,2HP4S@201174|Actinobacteria,4CQGE@84995|Rubrobacteria	84995|Rubrobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS2_k127_6095661_1	1283299.AUKG01000001_gene1449	8.724e-91	310.0	COG1300@1|root,COG1300@2|Bacteria,2GJTG@201174|Actinobacteria,4CPAF@84995|Rubrobacteria	84995|Rubrobacteria	S	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
TLS2_k127_6095661_5	208444.JNYY01000022_gene3124	7.823e-61	223.0	COG0147@1|root,COG0147@2|Bacteria,2GN7D@201174|Actinobacteria,4E1ES@85010|Pseudonocardiales	201174|Actinobacteria	EH	aminodeoxychorismate synthase	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Chorismate_bind
TLS2_k127_6095661_9	1123065.ATWL01000001_gene195	5.397e-46	183.0	COG0115@1|root,COG0115@2|Bacteria,2GN5Z@201174|Actinobacteria	201174|Actinobacteria	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	pabC	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
TLS2_k127_6095661_13	385682.AFSL01000019_gene2242	1.035e-32	138.0	COG0518@1|root,COG0518@2|Bacteria,4NMFC@976|Bacteroidetes,2FS4D@200643|Bacteroidia,3XKVB@558415|Marinilabiliaceae	976|Bacteroidetes	F	Glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
TLS2_k127_6095661_0	867903.ThesuDRAFT_01142	1.237e-139	458.0	COG1139@1|root,COG1556@1|root,COG1139@2|Bacteria,COG1556@2|Bacteria,1TREQ@1239|Firmicutes,24BXS@186801|Clostridia	186801|Clostridia	C	Iron-sulfur cluster-binding protein	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
TLS2_k127_6095661_15	768671.ThimaDRAFT_1308	1.372e-15	89.0	COG1556@1|root,COG1556@2|Bacteria,1R4TE@1224|Proteobacteria,1S6IK@1236|Gammaproteobacteria,1WZ86@135613|Chromatiales	135613|Chromatiales	S	Pfam:DUF162	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
TLS2_k127_6095661_17	1206731.BAGB01000015_gene1830	1.173e-11	76.0	COG2897@1|root,COG2897@2|Bacteria,2GMDR@201174|Actinobacteria,4FXYK@85025|Nocardiaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	ApbA,ApbA_C,Rhodanese
TLS2_k127_6095661_12	103733.JNYO01000029_gene783	2.022e-34	150.0	COG2267@1|root,COG2267@2|Bacteria,2II4K@201174|Actinobacteria,4EFDB@85010|Pseudonocardiales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
TLS2_k127_6095661_7	685778.AORL01000010_gene3189	2.98e-46	175.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2TRSG@28211|Alphaproteobacteria,2K0CJ@204457|Sphingomonadales	204457|Sphingomonadales	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS2_k127_6095661_16	1384056.N787_11695	3.429e-14	84.0	COG4496@1|root,COG4496@2|Bacteria,1NAAX@1224|Proteobacteria,1SG3S@1236|Gammaproteobacteria,1X7DY@135614|Xanthomonadales	135614|Xanthomonadales	S	protein, YerC YecD	-	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
TLS2_k127_6095661_4	1094980.Mpsy_1892	4.251e-62	229.0	COG0040@1|root,arCOG02208@2157|Archaea,2XTZ3@28890|Euryarchaeota,2N9AD@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
TLS2_k127_6095661_3	1293047.CBMA010000033_gene2177	1.441e-68	256.0	COG0141@1|root,arCOG04352@2157|Archaea,2XT6M@28890|Euryarchaeota,23SH9@183963|Halobacteria	183963|Halobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
TLS2_k127_6095661_10	219305.MCAG_01194	1.162e-41	176.0	COG0131@1|root,COG0131@2|Bacteria,2GKMD@201174|Actinobacteria,4D8JJ@85008|Micromonosporales	201174|Actinobacteria	E	Imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,4.2.1.19	ko:K01089,ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013,R03457	RC00017,RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
TLS2_k127_6095661_14	404589.Anae109_0755	1.131e-32	147.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,42QX8@68525|delta/epsilon subdivisions,2WMNR@28221|Deltaproteobacteria,2YV5Y@29|Myxococcales	28221|Deltaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS2_k127_6095661_2	84588.SYNW1675	5.762e-73	273.0	COG0107@1|root,COG0107@2|Bacteria,1G18S@1117|Cyanobacteria,1GYGN@1129|Synechococcus	1117|Cyanobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS2_k127_6095661_8	1384056.N787_11655	4.138e-46	174.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1X4HM@135614|Xanthomonadales	135614|Xanthomonadales	E	Histidine biosynthesis bifunctional protein HisIE	hisI	-	3.5.4.19,3.6.1.31	ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
TLS2_k127_6095661_11	263358.VAB18032_00050	1.017e-40	166.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4D96T@85008|Micromonosporales	201174|Actinobacteria	G	Inositol monophosphatase	hisN	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS2_k127_6099550_8	469383.Cwoe_3807	1.351e-07	62.0	2DNW5@1|root,32ZGI@2|Bacteria,2IQ5T@201174|Actinobacteria	201174|Actinobacteria	S	Rho termination factor	-	-	-	-	-	-	-	-	-	-	-	-	Rho_N
TLS2_k127_6099550_3	1380390.JIAT01000014_gene6248	3.193e-48	191.0	COG0625@1|root,COG0625@2|Bacteria,2HPB4@201174|Actinobacteria,4CQPC@84995|Rubrobacteria	84995|Rubrobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_3
TLS2_k127_6099550_1	479434.Sthe_0341	2.583e-104	341.0	COG2041@1|root,COG2041@2|Bacteria,2G6ES@200795|Chloroflexi	200795|Chloroflexi	S	PFAM oxidoreductase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
TLS2_k127_6099550_2	404589.Anae109_1054	1.505e-79	281.0	COG1018@1|root,COG1018@2|Bacteria,1R5FN@1224|Proteobacteria	1224|Proteobacteria	C	Oxidoreductase FAD-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
TLS2_k127_6099550_6	1352941.M877_38540	2.434e-14	85.0	2E4G6@1|root,32ZBB@2|Bacteria,2GR6E@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6099550_5	1120936.KB907209_gene1397	8.983e-16	78.0	COG1983@1|root,COG1983@2|Bacteria,2GQG0@201174|Actinobacteria,4EKZT@85012|Streptosporangiales	201174|Actinobacteria	KT	PspC domain	pspC1	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
TLS2_k127_6099550_4	1396418.BATQ01000171_gene2901	2.279e-36	158.0	COG0662@1|root,COG0662@2|Bacteria,46VA6@74201|Verrucomicrobia,2IVWA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS2_k127_6099550_0	469383.Cwoe_3753	6.526e-185	594.0	COG1003@1|root,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria,4CPH8@84995|Rubrobacteria	84995|Rubrobacteria	E	Aminotransferase class-V	-	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
TLS2_k127_6099550_7	1380390.JIAT01000010_gene4158	4.252e-10	62.0	COG0403@1|root,COG0403@2|Bacteria,2IBH2@201174|Actinobacteria,4CP8Z@84995|Rubrobacteria	84995|Rubrobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
TLS2_k127_6215050_5	391625.PPSIR1_00807	6.805e-28	124.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,43BP2@68525|delta/epsilon subdivisions,2WK8X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	molybdopterin oxidoreductase Fe4S4 region	sfrA	-	1.17.1.10	ko:K05299	ko00680,ko00720,ko01100,ko01120,ko01200,map00680,map00720,map01100,map01120,map01200	M00377	R00134	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4_10,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
TLS2_k127_6215050_4	1380394.JADL01000004_gene6050	6.735e-44	164.0	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,2UC7G@28211|Alphaproteobacteria,2JTQX@204441|Rhodospirillales	204441|Rhodospirillales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS2_k127_6215050_1	35754.JNYJ01000065_gene5699	1.087e-114	404.0	COG3844@1|root,COG3844@2|Bacteria,2GMJQ@201174|Actinobacteria,4DBYN@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
TLS2_k127_6215050_2	391595.RLO149_c010280	1.01e-108	370.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria,2P1IV@2433|Roseobacter	28211|Alphaproteobacteria	C	Formate dehydrogenase, beta subunit	nuoEF	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
TLS2_k127_6215050_0	926560.KE387023_gene2040	9.944e-117	414.0	COG0624@1|root,COG0624@2|Bacteria,1WMBR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS2_k127_6215050_3	1380390.JIAT01000011_gene2827	8.11e-83	282.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria,4CQ2Z@84995|Rubrobacteria	84995|Rubrobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
TLS2_k127_6215050_6	208439.AJAP_09360	2.895e-08	66.0	COG2068@1|root,COG2068@2|Bacteria,2GK5R@201174|Actinobacteria,4E42U@85010|Pseudonocardiales	201174|Actinobacteria	S	MobA-like NTP transferase domain	nboR	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TLS2_k127_630831_3	469383.Cwoe_3197	1.489e-64	226.0	COG1234@1|root,COG1234@2|Bacteria,2GJT2@201174|Actinobacteria,4CRBC@84995|Rubrobacteria	84995|Rubrobacteria	S	Beta-lactamase superfamily domain	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
TLS2_k127_630831_6	266117.Rxyl_0857	2.217e-09	63.0	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
TLS2_k127_630831_5	1380390.JIAT01000009_gene352	1.36e-42	160.0	COG0622@1|root,COG0622@2|Bacteria,2IFVB@201174|Actinobacteria,4CQCK@84995|Rubrobacteria	84995|Rubrobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
TLS2_k127_630831_0	309801.trd_A0613	9.008e-119	396.0	COG2309@1|root,COG2309@2|Bacteria,2G62B@200795|Chloroflexi,27YZB@189775|Thermomicrobia	189775|Thermomicrobia	E	Thermophilic metalloprotease (M29)	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
TLS2_k127_630831_1	357808.RoseRS_2644	8.906e-115	383.0	COG2309@1|root,COG2309@2|Bacteria,2G5TH@200795|Chloroflexi,376Y0@32061|Chloroflexia	32061|Chloroflexia	E	PFAM peptidase M29, aminopeptidase II	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
TLS2_k127_630831_2	1146883.BLASA_0283	6.18e-97	334.0	COG3367@1|root,COG3367@2|Bacteria,2IBUZ@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
TLS2_k127_630831_4	378806.STAUR_0696	5.886e-64	237.0	COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,42Q93@68525|delta/epsilon subdivisions,2WKAA@28221|Deltaproteobacteria,2YYHJ@29|Myxococcales	28221|Deltaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS2_k127_630831_7	882083.SacmaDRAFT_3032	1.634e-08	57.0	COG5276@1|root,COG5276@2|Bacteria,2IAAZ@201174|Actinobacteria,4EAHD@85010|Pseudonocardiales	201174|Actinobacteria	O	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD,P_proprotein
TLS2_k127_6337505_0	1128421.JAGA01000002_gene234	5.647e-145	465.0	COG1350@1|root,COG1350@2|Bacteria,2NNY3@2323|unclassified Bacteria	2|Bacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS2_k127_6337505_2	469383.Cwoe_0896	4.513e-72	253.0	COG0739@1|root,COG3409@1|root,COG0739@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	nlpD	-	-	-	-	-	-	-	-	-	-	-	G5,LysM,PG_binding_1,Peptidase_M23
TLS2_k127_6337505_1	266117.Rxyl_0584	1.229e-97	329.0	COG0402@1|root,COG0402@2|Bacteria,2GZ2Q@201174|Actinobacteria,4CPN7@84995|Rubrobacteria	84995|Rubrobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS2_k127_6337505_3	904306.HMPREF9192_1884	5.852e-15	81.0	COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,4HCEX@91061|Bacilli	91061|Bacilli	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS06365	CDP-OH_P_transf
TLS2_k127_6398551_1	867845.KI911784_gene381	2.852e-58	209.0	COG0745@1|root,COG0745@2|Bacteria,2GBG4@200795|Chloroflexi,376MR@32061|Chloroflexia	32061|Chloroflexia	K	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_6398551_2	1172188.KB911820_gene3085	1.076e-30	140.0	28RB9@1|root,2ZDQU@2|Bacteria,2GZQK@201174|Actinobacteria,4FIZG@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6398551_0	479434.Sthe_0805	8.885e-217	683.0	COG1012@1|root,COG1012@2|Bacteria,2G5JZ@200795|Chloroflexi,27Y57@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the aldehyde dehydrogenase family	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS2_k127_6398551_4	1122247.C731_2701	2.927e-28	120.0	COG0327@1|root,COG0327@2|Bacteria,2GKHZ@201174|Actinobacteria,233QH@1762|Mycobacteriaceae	201174|Actinobacteria	S	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
TLS2_k127_6398551_3	867903.ThesuDRAFT_00795	1.507e-30	129.0	COG0328@1|root,COG2384@1|root,COG0328@2|Bacteria,COG2384@2|Bacteria,1V3I4@1239|Firmicutes,24BJI@186801|Clostridia,3WDGE@538999|Clostridiales incertae sedis	186801|Clostridia	L	tRNA (adenine(22)-N(1))-methyltransferase	trmK	-	2.1.1.217	ko:K06967	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_18,TrmK
TLS2_k127_6412208_3	471853.Bcav_2472	1.513e-27	117.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
TLS2_k127_6412208_0	469383.Cwoe_3233	2.327e-139	473.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4CPQG@84995|Rubrobacteria	84995|Rubrobacteria	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS2_k127_6412208_1	365528.KB891209_gene2220	1.76e-55	210.0	COG0644@1|root,COG0644@2|Bacteria,2GMH9@201174|Actinobacteria	201174|Actinobacteria	C	geranylgeranyl reductase	fixC	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS2_k127_6412208_2	469383.Cwoe_3232	1.951e-50	185.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4CPRU@84995|Rubrobacteria	84995|Rubrobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TLS2_k127_651685_2	1121346.KB899810_gene1438	3.85e-53	199.0	COG0667@1|root,COG0667@2|Bacteria,1TQYY@1239|Firmicutes,4HDCC@91061|Bacilli,26T55@186822|Paenibacillaceae	91061|Bacilli	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS2_k127_651685_0	415426.Hbut_1358	3.447e-104	363.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPPI@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
TLS2_k127_651685_3	67257.JODR01000001_gene745	7.27e-26	116.0	COG4549@1|root,COG4549@2|Bacteria,2GN9H@201174|Actinobacteria	201174|Actinobacteria	S	nuclear export factor GLE1	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF1775
TLS2_k127_651685_1	509190.Cseg_1208	4.434e-83	286.0	COG2374@1|root,COG2374@2|Bacteria,1R5QF@1224|Proteobacteria,2U002@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS2_k127_651685_4	1380390.JIAT01000015_gene5823	9.552e-17	84.0	COG1983@1|root,COG1983@2|Bacteria	2|Bacteria	KT	positive regulation of macromolecule biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PspC,zf-ribbon_3
TLS2_k127_6551544_28	1121272.KB903253_gene6866	8.306e-15	76.0	COG3832@1|root,COG3832@2|Bacteria,2IG6F@201174|Actinobacteria,4DDVZ@85008|Micromonosporales	201174|Actinobacteria	S	PFAM Activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_6551544_19	1125863.JAFN01000001_gene3323	5.326e-36	154.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,42SBD@68525|delta/epsilon subdivisions,2WP9P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
TLS2_k127_6551544_0	1283299.AUKG01000001_gene2658	1.092e-129	421.0	COG0202@1|root,COG0202@2|Bacteria,2GJJ5@201174|Actinobacteria,4CPU6@84995|Rubrobacteria	84995|Rubrobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
TLS2_k127_6551544_4	1283299.AUKG01000001_gene2657	1.632e-90	304.0	COG0522@1|root,COG0522@2|Bacteria,2GIRX@201174|Actinobacteria,4CQ5S@84995|Rubrobacteria	84995|Rubrobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
TLS2_k127_6551544_11	469383.Cwoe_1365	1.871e-62	216.0	COG0100@1|root,COG0100@2|Bacteria,2IFFC@201174|Actinobacteria,4CPZ7@84995|Rubrobacteria	84995|Rubrobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
TLS2_k127_6551544_13	986075.CathTA2_2507	2.178e-46	169.0	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,4HGX6@91061|Bacilli	91061|Bacilli	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
TLS2_k127_6551544_27	469383.Cwoe_1363	4.616e-15	76.0	COG0257@1|root,COG0257@2|Bacteria,2GWMH@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
TLS2_k127_6551544_5	266117.Rxyl_2133	1.765e-89	308.0	COG0024@1|root,COG0024@2|Bacteria,2GKKB@201174|Actinobacteria,4CPA2@84995|Rubrobacteria	84995|Rubrobacteria	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS2_k127_6551544_18	565653.EGBG_02126	5.629e-37	161.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,4HA89@91061|Bacilli,4AZMC@81852|Enterococcaceae	91061|Bacilli	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0003674,GO:0003824,GO:0004017,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
TLS2_k127_6551544_1	1121289.JHVL01000024_gene142	1.829e-127	419.0	COG0201@1|root,COG0201@2|Bacteria,1TPHB@1239|Firmicutes,248T9@186801|Clostridia,36F8Y@31979|Clostridiaceae	186801|Clostridia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
TLS2_k127_6551544_16	469383.Cwoe_1359	1.569e-39	156.0	COG0200@1|root,COG0200@2|Bacteria,2II6M@201174|Actinobacteria,4CQD8@84995|Rubrobacteria	84995|Rubrobacteria	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
TLS2_k127_6551544_29	478801.Ksed_20690	9.105e-12	70.0	COG1841@1|root,COG1841@2|Bacteria,2GQV0@201174|Actinobacteria,1ZW8B@145357|Dermacoccaceae	201174|Actinobacteria	J	ribosomal protein L30	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
TLS2_k127_6551544_10	1283299.AUKG01000001_gene2648	1.615e-62	229.0	COG0098@1|root,COG0098@2|Bacteria,2GJW8@201174|Actinobacteria,4CPMN@84995|Rubrobacteria	84995|Rubrobacteria	J	Belongs to the universal ribosomal protein uS5 family	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
TLS2_k127_6551544_20	983548.Krodi_1847	2.747e-32	137.0	COG0256@1|root,COG0256@2|Bacteria,4NQAS@976|Bacteroidetes,1I2S3@117743|Flavobacteriia,37F85@326319|Dokdonia	976|Bacteroidetes	J	Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
TLS2_k127_6551544_7	469383.Cwoe_1355	7.839e-72	249.0	COG0097@1|root,COG0097@2|Bacteria,2GK35@201174|Actinobacteria,4CQ44@84995|Rubrobacteria	84995|Rubrobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
TLS2_k127_6551544_14	469371.Tbis_0576	5.179e-46	169.0	COG0096@1|root,COG0096@2|Bacteria,2IHQZ@201174|Actinobacteria,4E2N4@85010|Pseudonocardiales	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
TLS2_k127_6551544_24	1223523.H340_17006	2.964e-25	105.0	COG0199@1|root,COG0199@2|Bacteria,2IQ8R@201174|Actinobacteria	201174|Actinobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
TLS2_k127_6551544_8	1120978.KB894084_gene346	4.023e-71	251.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,4HBAX@91061|Bacilli,27FXS@186828|Carnobacteriaceae	91061|Bacilli	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
TLS2_k127_6551544_22	1231241.Mc24_04220	1.629e-27	124.0	COG0198@1|root,COG0198@2|Bacteria,2GD31@200918|Thermotogae	200918|Thermotogae	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
TLS2_k127_6551544_12	1380390.JIAT01000011_gene2598	1.601e-54	203.0	COG0093@1|root,COG0093@2|Bacteria,2IHNX@201174|Actinobacteria,4CQ56@84995|Rubrobacteria	84995|Rubrobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
TLS2_k127_6551544_25	1283299.AUKG01000001_gene2640	1.377e-20	101.0	COG0186@1|root,COG0186@2|Bacteria,2IQ68@201174|Actinobacteria,4CQJP@84995|Rubrobacteria	84995|Rubrobacteria	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
TLS2_k127_6551544_26	644966.Tmar_2287	3.525e-15	77.0	COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,24QV1@186801|Clostridia,3WCNW@538999|Clostridiales incertae sedis	186801|Clostridia	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
TLS2_k127_6551544_9	469383.Cwoe_1347	5.416e-65	224.0	COG0197@1|root,COG0197@2|Bacteria,2IFEI@201174|Actinobacteria,4CQ15@84995|Rubrobacteria	84995|Rubrobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
TLS2_k127_6551544_3	1380390.JIAT01000011_gene2594	6.567e-98	341.0	COG0092@1|root,COG0092@2|Bacteria,2GKF1@201174|Actinobacteria,4CPWK@84995|Rubrobacteria	84995|Rubrobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
TLS2_k127_6551544_23	1384484.AEQU_1478	2.239e-27	120.0	COG0091@1|root,COG0091@2|Bacteria,2IM3J@201174|Actinobacteria,4CW1D@84998|Coriobacteriia	84998|Coriobacteriia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
TLS2_k127_6551544_15	661087.HMPREF1008_00624	2.912e-42	156.0	COG0185@1|root,COG0185@2|Bacteria,2IKMS@201174|Actinobacteria,4CW3A@84998|Coriobacteriia	84998|Coriobacteriia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
TLS2_k127_6551544_2	502558.EGYY_24430	1.689e-122	404.0	COG0090@1|root,COG0090@2|Bacteria,2GK7R@201174|Actinobacteria,4CUAA@84998|Coriobacteriia	84998|Coriobacteriia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
TLS2_k127_6551544_21	469383.Cwoe_1342	1.849e-31	125.0	COG0089@1|root,COG0089@2|Bacteria,2IQ7V@201174|Actinobacteria,4CQIU@84995|Rubrobacteria	84995|Rubrobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
TLS2_k127_6551544_17	469383.Cwoe_1341	6.424e-39	161.0	COG0088@1|root,COG0088@2|Bacteria,2GJYJ@201174|Actinobacteria,4CPXR@84995|Rubrobacteria	84995|Rubrobacteria	J	50S ribosomal protein L4	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
TLS2_k127_6551544_6	1122939.ATUD01000003_gene3566	1.909e-76	261.0	COG0087@1|root,COG0087@2|Bacteria,2GJXT@201174|Actinobacteria,4CPFD@84995|Rubrobacteria	84995|Rubrobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
TLS2_k127_6560671_2	880072.Desac_2551	1.312e-56	205.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,42N6I@68525|delta/epsilon subdivisions,2WK7S@28221|Deltaproteobacteria,2MQG1@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
TLS2_k127_6560671_1	926560.KE387023_gene2224	1.032e-57	208.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	eryCVI	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0046983	2.1.1.234	ko:K13311,ko:K13326,ko:K21335	ko00523,ko01130,map00523,map01130	M00797,M00800	R06427,R11045,R11476	RC00003,RC01515,RC02262	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
TLS2_k127_6560671_0	469383.Cwoe_1805	9.856e-155	520.0	COG1074@1|root,COG1074@2|Bacteria,2GNKH@201174|Actinobacteria,4CPD7@84995|Rubrobacteria	84995|Rubrobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS2_k127_6569034_5	562970.Btus_2870	1.82e-17	87.0	COG1494@1|root,COG1494@2|Bacteria,1TP0D@1239|Firmicutes,4H9MV@91061|Bacilli,277X5@186823|Alicyclobacillaceae	91061|Bacilli	G	TIGRFAM fructose-1,6-bisphosphatase, class II	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
TLS2_k127_6569034_2	1330700.JQNC01000003_gene160	2.181e-53	213.0	COG2074@1|root,COG2074@2|Bacteria,1WI2U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	2-phosphoglycerate kinase	-	-	-	ko:K05715	-	-	R02664	RC00002,RC00017	ko00000,ko01000	-	-	-	AAA_33,ATP-cone
TLS2_k127_6569034_0	266117.Rxyl_1657	5.844e-109	380.0	COG2403@1|root,COG2403@2|Bacteria,2H3G5@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP	cpgS	-	-	ko:K05716	-	-	R03298	RC00900	ko00000,ko01000	-	-	-	-
TLS2_k127_6569034_1	266117.Rxyl_1658	9.085e-98	330.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	CP_0969	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
TLS2_k127_6569034_4	234267.Acid_0127	1.024e-31	129.0	COG1102@1|root,COG1102@2|Bacteria	2|Bacteria	F	Psort location Cytoplasmic, score	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Cytidylate_kin2,GAF_2,Pribosyltran
TLS2_k127_6569034_3	1283299.AUKG01000001_gene2922	1.024e-31	129.0	COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,4CPVX@84995|Rubrobacteria	84995|Rubrobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS2_k127_6584126_2	469383.Cwoe_3034	4.22e-104	352.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4CPQA@84995|Rubrobacteria	84995|Rubrobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS2_k127_6584126_17	1122939.ATUD01000005_gene2614	7.207e-23	102.0	COG0816@1|root,COG0816@2|Bacteria,2HPE8@201174|Actinobacteria,4CQSC@84995|Rubrobacteria	84995|Rubrobacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
TLS2_k127_6584126_15	1380390.JIAT01000017_gene5302	1.256e-41	171.0	COG1559@1|root,COG1559@2|Bacteria,2GKGQ@201174|Actinobacteria,4CQ8A@84995|Rubrobacteria	84995|Rubrobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
TLS2_k127_6584126_11	1229780.BN381_50132	1.992e-50	194.0	COG0169@1|root,COG0169@2|Bacteria,2GPQQ@201174|Actinobacteria,3UWXN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Shikimate dehydrogenase substrate binding domain	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
TLS2_k127_6584126_14	1463825.JNXC01000022_gene571	1.88e-42	176.0	COG2304@1|root,COG2304@2|Bacteria,2IDJD@201174|Actinobacteria	201174|Actinobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
TLS2_k127_6584126_3	369723.Strop_1845	3.476e-99	336.0	COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4DAFR@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2540c	Chorismate_synt
TLS2_k127_6584126_5	1122939.ATUD01000005_gene2634	1.236e-81	293.0	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria,4CPMA@84995|Rubrobacteria	84995|Rubrobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
TLS2_k127_6584126_13	929712.KI912613_gene3456	1.022e-46	171.0	COG0757@1|root,COG0757@2|Bacteria,2IMBY@201174|Actinobacteria,4CQJK@84995|Rubrobacteria	84995|Rubrobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
TLS2_k127_6584126_6	1068978.AMETH_4152	3.795e-73	265.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4DYZ4@85010|Pseudonocardiales	201174|Actinobacteria	E	Creatinase Prolidase N-terminal domain	pepQ	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
TLS2_k127_6584126_9	635013.TherJR_1731	4.491e-58	218.0	COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,249DV@186801|Clostridia,261EB@186807|Peptococcaceae	186801|Clostridia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TLS2_k127_6584126_1	1034345.CAEM01000025_gene1093	4.391e-106	366.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,2IR3V@201174|Actinobacteria,4CUB4@84998|Coriobacteriia	84998|Coriobacteriia	CI	Acetyl-CoA carboxylase, biotin carboxyl carrier protein	-	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
TLS2_k127_6584126_0	745310.G432_17935	9.721e-156	504.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2U25Z@28211|Alphaproteobacteria,2K11Z@204457|Sphingomonadales	204457|Sphingomonadales	I	An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TLS2_k127_6584126_19	861299.J421_3118	5.271e-14	85.0	COG0781@1|root,COG0781@2|Bacteria,1ZTRU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
TLS2_k127_6584126_8	469383.Cwoe_3075	1.047e-70	251.0	COG0142@1|root,COG0142@2|Bacteria,2GN1P@201174|Actinobacteria,4CP7H@84995|Rubrobacteria	84995|Rubrobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS2_k127_6584126_12	1173026.Glo7428_4746	1.896e-49	195.0	arCOG12117@1|root,2Z9N1@2|Bacteria,1G2YP@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF3891)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3891
TLS2_k127_6584126_18	313589.JNB_11639	2.413e-15	80.0	COG1950@1|root,COG1950@2|Bacteria,2IHP5@201174|Actinobacteria,4FHD0@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
TLS2_k127_6584126_7	469383.Cwoe_3080	4.108e-72	251.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,4CQ7R@84995|Rubrobacteria	84995|Rubrobacteria	J	FtsJ-like methyltransferase	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
TLS2_k127_6584126_10	1283299.AUKG01000002_gene5315	8.672e-51	193.0	COG0061@1|root,COG0061@2|Bacteria,2GKM2@201174|Actinobacteria,4CPFG@84995|Rubrobacteria	84995|Rubrobacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
TLS2_k127_6584126_4	266117.Rxyl_1453	2.216e-87	309.0	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4CPSV@84995|Rubrobacteria	84995|Rubrobacteria	L	May be involved in recombinational repair of damaged DNA	-	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
TLS2_k127_6584126_16	656024.FsymDg_3249	1.85e-35	137.0	COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria,4ERGE@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1699	CTP_synth_N,GATase
TLS2_k127_6591951_1	251221.35211202	1.395e-96	343.0	COG3119@1|root,COG3119@2|Bacteria,1G5IZ@1117|Cyanobacteria	1117|Cyanobacteria	P	Arylsulfatase a	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase,Sulfatase_C
TLS2_k127_6591951_2	251221.35211202	8.201e-95	334.0	COG3119@1|root,COG3119@2|Bacteria,1G5IZ@1117|Cyanobacteria	1117|Cyanobacteria	P	Arylsulfatase a	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase,Sulfatase_C
TLS2_k127_6591951_0	68219.JNXI01000015_gene654	4.785e-143	467.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
TLS2_k127_6610533_5	370438.PTH_1123	2.065e-34	142.0	COG0863@1|root,COG0863@2|Bacteria,1UZ5E@1239|Firmicutes,24F8E@186801|Clostridia	186801|Clostridia	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
TLS2_k127_6610533_6	1229780.BN381_10023	1.106e-19	98.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Fer4_7,HTH_Crp_2,cNMP_binding
TLS2_k127_6610533_8	1380390.JIAT01000009_gene501	1.219e-10	64.0	2DRBI@1|root,33B4D@2|Bacteria,2GWXK@201174|Actinobacteria,4CQVA@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6610533_1	469371.Tbis_3390	7.724e-100	341.0	COG2197@1|root,COG2197@2|Bacteria,2GJHH@201174|Actinobacteria,4E29S@85010|Pseudonocardiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	ko:K07696	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
TLS2_k127_6610533_0	457429.ABJI02000751_gene5291	4.533e-100	335.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA_3
TLS2_k127_6610533_9	1267600.JFGT01000005_gene2990	0.0009289	51.0	COG2261@1|root,COG2261@2|Bacteria,1P15D@1224|Proteobacteria,1SSC2@1236|Gammaproteobacteria,3W19X@53335|Pantoea	1236|Gammaproteobacteria	S	transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6610533_2	479434.Sthe_2401	4.003e-88	318.0	COG0642@1|root,COG2203@1|root,COG3829@1|root,COG5000@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,COG5000@2|Bacteria,2G7SE@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
TLS2_k127_6610533_3	2074.JNYD01000010_gene986	1.342e-69	249.0	COG1929@1|root,COG1929@2|Bacteria,2GKHX@201174|Actinobacteria,4DXZB@85010|Pseudonocardiales	201174|Actinobacteria	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
TLS2_k127_6610533_7	1379698.RBG1_1C00001G1771	1.1e-13	85.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS2_k127_6610533_4	266117.Rxyl_2620	2.463e-59	217.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,4CPA3@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,LPG_synthase_TM
TLS2_k127_6610943_7	106370.Francci3_0808	4.522e-05	49.0	COG2253@1|root,COG2253@2|Bacteria	2|Bacteria	V	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
TLS2_k127_6610943_6	1380390.JIAT01000010_gene4359	1.363e-16	92.0	COG0125@1|root,COG0125@2|Bacteria,2H78H@201174|Actinobacteria	201174|Actinobacteria	F	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6610943_4	526225.Gobs_0399	3.747e-23	110.0	COG1216@1|root,COG1216@2|Bacteria,2HF66@201174|Actinobacteria,4EWY9@85013|Frankiales	201174|Actinobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_6610943_0	1386089.N865_00425	3.04e-155	516.0	COG2409@1|root,COG2409@2|Bacteria,2GIRQ@201174|Actinobacteria	201174|Actinobacteria	T	PFAM MMPL domain protein	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
TLS2_k127_6610943_5	479434.Sthe_2635	2.045e-18	99.0	2E4KM@1|root,32ZFK@2|Bacteria,2GBAS@200795|Chloroflexi,27YJQ@189775|Thermomicrobia	189775|Thermomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
TLS2_k127_6610943_1	1163409.UUA_11238	5.329e-75	267.0	COG2010@1|root,COG2132@1|root,COG2010@2|Bacteria,COG2132@2|Bacteria,1MV74@1224|Proteobacteria,1RXZF@1236|Gammaproteobacteria,1X3IK@135614|Xanthomonadales	135614|Xanthomonadales	CQ	Multicopper oxidase	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_3,Cytochrome_CBB3
TLS2_k127_6610943_2	1078020.KEK_03787	3.241e-33	142.0	COG2345@1|root,COG2345@2|Bacteria,2IAWJ@201174|Actinobacteria,233RT@1762|Mycobacteriaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_IclR
TLS2_k127_6610943_3	469383.Cwoe_1816	2.291e-23	102.0	COG0438@1|root,COG0438@2|Bacteria,2GR58@201174|Actinobacteria,4CPE6@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_6615703_2	469383.Cwoe_5771	9.64e-13	81.0	COG4243@1|root,COG4243@2|Bacteria,2HGRK@201174|Actinobacteria,4CSQE@84995|Rubrobacteria	84995|Rubrobacteria	S	VKc	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
TLS2_k127_6615703_1	469383.Cwoe_5772	1.703e-43	171.0	COG1651@1|root,COG1651@2|Bacteria,2IGR9@201174|Actinobacteria	201174|Actinobacteria	O	Protein-disulfide isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
TLS2_k127_6615703_0	42256.RradSPS_2180	2.637e-149	494.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CPH0@84995|Rubrobacteria	84995|Rubrobacteria	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
TLS2_k127_6619819_1	101510.RHA1_ro02769	2.762e-46	173.0	2ADQJ@1|root,313FX@2|Bacteria,2H0DG@201174|Actinobacteria,4G1UD@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6619819_2	204669.Acid345_3970	1.899e-26	124.0	2DQJB@1|root,3377V@2|Bacteria,3Y8JD@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6619819_0	477974.Daud_0538	2.074e-54	207.0	COG2199@1|root,COG2203@1|root,COG3437@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,1V7YT@1239|Firmicutes,25ET2@186801|Clostridia,267DC@186807|Peptococcaceae	186801|Clostridia	T	Metal-dependent phosphohydrolase, HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HD,PAS,PocR,SBP_bac_3
TLS2_k127_6619819_3	572477.Alvin_0367	5.834e-17	92.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1WW40@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM Tyrosine recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS2_k127_6621287_7	292459.STH749	8.614e-20	91.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia	186801|Clostridia	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
TLS2_k127_6621287_1	1136417.AZWE01000015_gene1588	1.998e-116	384.0	COG0226@1|root,COG0226@2|Bacteria,2GMY1@201174|Actinobacteria	201174|Actinobacteria	P	phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	HSP70,PBP_like,PBP_like_2
TLS2_k127_6621287_2	1146883.BLASA_4537	5.28e-105	349.0	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria	201174|Actinobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS2_k127_6621287_3	469383.Cwoe_4494	1.22e-90	328.0	COG0581@1|root,COG0581@2|Bacteria,2I2F2@201174|Actinobacteria,4CQ28@84995|Rubrobacteria	84995|Rubrobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS2_k127_6621287_0	469383.Cwoe_4495	1.209e-117	385.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4CP9Q@84995|Rubrobacteria	84995|Rubrobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	-	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TLS2_k127_6621287_6	469383.Cwoe_4545	6.961e-46	175.0	COG0704@1|root,COG0704@2|Bacteria,2HGEG@201174|Actinobacteria,4CPTJ@84995|Rubrobacteria	84995|Rubrobacteria	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TLS2_k127_6621287_5	882086.SacxiDRAFT_4177	8.284e-48	185.0	COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria,4E4UE@85010|Pseudonocardiales	201174|Actinobacteria	T	Low molecular weight phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS2_k127_6621287_4	1003195.SCAT_2733	4.267e-68	240.0	COG0053@1|root,COG0053@2|Bacteria,2GQJJ@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Cation efflux	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
TLS2_k127_6622060_3	928724.SacglDRAFT_00072	7.392e-18	88.0	COG4759@1|root,COG4759@2|Bacteria,2GRSQ@201174|Actinobacteria,4DYIC@85010|Pseudonocardiales	201174|Actinobacteria	O	Sucrase/ferredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Suc_Fer-like
TLS2_k127_6622060_2	1449353.JQMQ01000005_gene1023	3.08e-77	276.0	COG2850@1|root,COG2850@2|Bacteria,2GMR2@201174|Actinobacteria,2NHVX@228398|Streptacidiphilus	201174|Actinobacteria	S	A domain family that is part of the cupin metalloenzyme superfamily.	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_4
TLS2_k127_6622060_0	469383.Cwoe_5543	1.953e-142	463.0	COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria,4CPVD@84995|Rubrobacteria	84995|Rubrobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
TLS2_k127_6622060_1	1380390.JIAT01000009_gene2137	8.562e-124	402.0	COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria,4CP6J@84995|Rubrobacteria	84995|Rubrobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
TLS2_k127_6637084_3	429009.Adeg_2147	2.83e-23	104.0	COG0357@1|root,COG0357@2|Bacteria,1W6WG@1239|Firmicutes,25MN8@186801|Clostridia,42IXD@68295|Thermoanaerobacterales	186801|Clostridia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
TLS2_k127_6637084_2	768710.DesyoDRAFT_5454	6.119e-31	138.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,260UK@186807|Peptococcaceae	186801|Clostridia	S	PFAM Single-stranded nucleic acid binding R3H	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
TLS2_k127_6637084_1	469383.Cwoe_5947	2.6e-46	183.0	COG0706@1|root,COG0706@2|Bacteria,2GJBU@201174|Actinobacteria,4CSZC@84995|Rubrobacteria	84995|Rubrobacteria	U	PFAM 60 kDa inner membrane insertion protein	-	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
TLS2_k127_6637084_4	1380390.JIAT01000009_gene1794	1.1e-22	106.0	COG0759@1|root,COG0759@2|Bacteria,2GQZG@201174|Actinobacteria,4CQSS@84995|Rubrobacteria	84995|Rubrobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
TLS2_k127_6637084_5	1380390.JIAT01000009_gene1793	2.61e-16	87.0	COG0594@1|root,COG0594@2|Bacteria,2GR42@201174|Actinobacteria,4CQCA@84995|Rubrobacteria	84995|Rubrobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
TLS2_k127_6637084_6	1121940.AUDZ01000013_gene638	8.808e-07	61.0	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,1SGDJ@1236|Gammaproteobacteria,1XMQA@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
TLS2_k127_6637084_0	198467.NP92_12015	1.449e-100	338.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,4H9MW@91061|Bacilli,21V4X@150247|Anoxybacillus	91061|Bacilli	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
TLS2_k127_6637835_7	1380390.JIAT01000009_gene1535	5.68e-88	314.0	COG0395@1|root,COG0395@2|Bacteria,2GJNN@201174|Actinobacteria,4CRU9@84995|Rubrobacteria	84995|Rubrobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10234	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
TLS2_k127_6637835_1	1380390.JIAT01000009_gene1536	3.115e-172	575.0	COG1175@1|root,COG1175@2|Bacteria,2GKYS@201174|Actinobacteria,4CRVK@84995|Rubrobacteria	84995|Rubrobacteria	G	SdrD B-like domain	-	-	-	ko:K10233	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1,SdrD_B
TLS2_k127_6637835_3	469383.Cwoe_2936	6.381e-162	533.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria,4CS8Q@84995|Rubrobacteria	84995|Rubrobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1
TLS2_k127_6637835_0	469383.Cwoe_2935	1.667e-175	559.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4CPPT@84995|Rubrobacteria	84995|Rubrobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
TLS2_k127_6637835_4	997346.HMPREF9374_1819	2.524e-157	503.0	COG0473@1|root,COG0473@2|Bacteria,1UJAS@1239|Firmicutes,4HCZN@91061|Bacilli,27BPR@186824|Thermoactinomycetaceae	91061|Bacilli	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Iso_dh
TLS2_k127_6637835_18	931627.MycrhDRAFT_6731	4.607e-13	81.0	COG1146@1|root,COG1146@2|Bacteria,2IKVN@201174|Actinobacteria,239CP@1762|Mycobacteriaceae	201174|Actinobacteria	C	ferredoxin	fdxA	-	-	-	-	-	-	-	-	-	-	-	Fer4
TLS2_k127_6637835_23	1158182.KB905029_gene2404	1.435e-06	54.0	2EEMA@1|root,338F7@2|Bacteria,1NDWI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6637835_21	1032480.MLP_10170	4.93e-09	66.0	COG1547@1|root,COG1547@2|Bacteria,2IHUS@201174|Actinobacteria,4DRD5@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF309)	-	-	-	ko:K09763	-	-	-	-	ko00000	-	-	-	DUF309
TLS2_k127_6637835_19	35754.JNYJ01000007_gene2947	9.006e-13	81.0	COG0454@1|root,COG0456@2|Bacteria,2IPDF@201174|Actinobacteria,4DG2Y@85008|Micromonosporales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_6637835_10	1380390.JIAT01000015_gene5703	1.177e-41	162.0	COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria,4CQ2F@84995|Rubrobacteria	84995|Rubrobacteria	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
TLS2_k127_6637835_17	1487923.DP73_10870	1.34e-13	82.0	COG3088@1|root,COG3088@2|Bacteria,1VETA@1239|Firmicutes,24TPT@186801|Clostridia,265EA@186807|Peptococcaceae	186801|Clostridia	P	subunit of a heme lyase	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
TLS2_k127_6637835_14	196162.Noca_1959	4.49e-28	123.0	COG0526@1|root,COG0526@2|Bacteria,2GP7J@201174|Actinobacteria	201174|Actinobacteria	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
TLS2_k127_6637835_11	1283299.AUKG01000001_gene2050	1.557e-33	141.0	COG1376@1|root,COG1376@2|Bacteria,2HNXN@201174|Actinobacteria,4CQ6A@84995|Rubrobacteria	84995|Rubrobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,YkuD
TLS2_k127_6637835_12	469383.Cwoe_5805	6.047e-29	135.0	COG0584@1|root,COG0584@2|Bacteria	2|Bacteria	C	glycerophosphodiester phosphodiesterase activity	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS2_k127_6637835_5	469383.Cwoe_1561	1.429e-129	430.0	COG4262@1|root,COG4262@2|Bacteria,2HNDH@201174|Actinobacteria,4CP6G@84995|Rubrobacteria	84995|Rubrobacteria	S	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
TLS2_k127_6637835_9	1288083.AUKR01000015_gene2749	9.053e-49	201.0	COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,2GKN8@201174|Actinobacteria	201174|Actinobacteria	T	SMART protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c_2,PAS,PAS_4,SpoIIE
TLS2_k127_6637835_16	266117.Rxyl_0735	2.258e-15	90.0	COG0671@1|root,COG0671@2|Bacteria,2IIA1@201174|Actinobacteria,4CQUT@84995|Rubrobacteria	84995|Rubrobacteria	I	PFAM phosphoesterase, PA-phosphatase related	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
TLS2_k127_6637835_15	1203568.HMPREF1484_01125	2.851e-21	102.0	COG0745@1|root,COG0745@2|Bacteria,2H3IN@201174|Actinobacteria,4FCH7@85020|Dermabacteraceae	201174|Actinobacteria	KT	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_6637835_13	1123024.AUII01000020_gene3248	6.326e-29	122.0	COG1507@1|root,COG1507@2|Bacteria,2I8CS@201174|Actinobacteria,4E2S8@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF501)	-	-	-	ko:K09009	-	-	-	-	ko00000	-	-	-	DUF501
TLS2_k127_6637835_22	1283299.AUKG01000003_gene586	1.196e-07	57.0	COG2919@1|root,COG2919@2|Bacteria,2HRMQ@201174|Actinobacteria,4CTPQ@84995|Rubrobacteria	84995|Rubrobacteria	D	Septum formation initiator	-	-	-	-	-	-	-	-	-	-	-	-	DivIC
TLS2_k127_6637835_6	163908.KB235896_gene1257	1.468e-118	416.0	COG0469@1|root,COG0469@2|Bacteria,1G1KV@1117|Cyanobacteria,1HJB2@1161|Nostocales	1117|Cyanobacteria	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
TLS2_k127_6637835_2	468556.AQYG01000034_gene3404	1.676e-170	557.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,4GBD0@85026|Gordoniaceae	201174|Actinobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TLS2_k127_6637835_8	469383.Cwoe_5239	5.301e-64	227.0	COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria,4CQXI@84995|Rubrobacteria	84995|Rubrobacteria	S	MazG nucleotide pyrophosphohydrolase domain	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	MazG
TLS2_k127_6647036_0	1382356.JQMP01000004_gene206	9.101e-68	256.0	COG1089@1|root,COG1089@2|Bacteria,2G5P2@200795|Chloroflexi,27XFT@189775|Thermomicrobia	189775|Thermomicrobia	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_6647036_1	1229780.BN381_10190	1.618e-61	236.0	COG1089@1|root,COG1089@2|Bacteria,2GNMA@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	-	-	1.1.1.281	ko:K15856	ko00051,ko00520,map00051,map00520	-	R03397,R03399	RC00182	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TLS2_k127_6647036_2	441620.Mpop_3532	6.328e-60	221.0	COG0438@1|root,COG0438@2|Bacteria,1MVA7@1224|Proteobacteria,2U0DX@28211|Alphaproteobacteria,1JU37@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS2_k127_6647036_3	926550.CLDAP_22690	2.434e-59	224.0	COG1215@1|root,COG2148@1|root,COG1215@2|Bacteria,COG2148@2|Bacteria,2G866@200795|Chloroflexi	200795|Chloroflexi	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,Glycos_transf_2
TLS2_k127_6647036_4	1122939.ATUD01000016_gene1819	3.344e-50	198.0	COG3307@1|root,COG3307@2|Bacteria,2HREZ@201174|Actinobacteria,4CTDF@84995|Rubrobacteria	84995|Rubrobacteria	M	O-antigen ligase like membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TLS2_k127_6657203_8	469383.Cwoe_2902	3.401e-16	80.0	COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria,4CPVR@84995|Rubrobacteria	84995|Rubrobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,DUF836,Put_DNA-bind_N
TLS2_k127_6657203_7	469383.Cwoe_2901	2.182e-18	89.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF836
TLS2_k127_6657203_0	357808.RoseRS_1722	8.77e-150	484.0	COG0334@1|root,COG0334@2|Bacteria,2G5SR@200795|Chloroflexi,376F1@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS2_k127_6657203_5	1288484.APCS01000037_gene1677	1.295e-25	124.0	COG1404@1|root,COG1404@2|Bacteria,1WJQ0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,PA,Peptidase_S8,fn3_5
TLS2_k127_6657203_1	266117.Rxyl_0812	1.486e-90	321.0	COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria,4CPNE@84995|Rubrobacteria	84995|Rubrobacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TLS2_k127_6657203_3	1380390.JIAT01000016_gene5510	1.767e-38	158.0	COG0454@1|root,COG0456@2|Bacteria,2HPAC@201174|Actinobacteria,4CQNP@84995|Rubrobacteria	84995|Rubrobacteria	K	FR47-like protein	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TLS2_k127_6657203_6	1122611.KB903951_gene6284	1.817e-23	108.0	COG1214@1|root,COG1214@2|Bacteria,2GMTM@201174|Actinobacteria,4EJ29@85012|Streptosporangiales	201174|Actinobacteria	O	Glycoprotease family	yeaZ	GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
TLS2_k127_6657203_4	469383.Cwoe_2896	9.692e-35	147.0	COG0802@1|root,COG0802@2|Bacteria,2IKV2@201174|Actinobacteria,4CQQP@84995|Rubrobacteria	84995|Rubrobacteria	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
TLS2_k127_6657203_2	469383.Cwoe_2893	2.264e-65	237.0	COG1573@1|root,COG1573@2|Bacteria,2GMPT@201174|Actinobacteria,4CQC2@84995|Rubrobacteria	84995|Rubrobacteria	L	TIGRFAM phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_6657203_9	525146.Ddes_1286	3.032e-09	63.0	COG2331@1|root,COG2331@2|Bacteria,1NGC1@1224|Proteobacteria,42W5D@68525|delta/epsilon subdivisions,2WRAY@28221|Deltaproteobacteria,2MD4Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	TIGRFAM regulatory protein, FmdB	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TLS2_k127_6660390_5	309801.trd_A0619	5.58e-24	114.0	COG4274@1|root,COG4274@2|Bacteria,2GBAJ@200795|Chloroflexi,27YIF@189775|Thermomicrobia	189775|Thermomicrobia	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
TLS2_k127_6660390_7	1244869.H261_06219	2.869e-10	72.0	COG3770@1|root,COG3770@2|Bacteria,1MU9I@1224|Proteobacteria,2TR3K@28211|Alphaproteobacteria,2JSKX@204441|Rhodospirillales	204441|Rhodospirillales	M	Penicillin-insensitive murein endopeptidase	mepA	-	-	ko:K07261	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M74
TLS2_k127_6660390_2	1380390.JIAT01000009_gene2098	5.745e-48	181.0	COG2866@1|root,COG2866@2|Bacteria,2HPMB@201174|Actinobacteria,4CQZA@84995|Rubrobacteria	84995|Rubrobacteria	E	Protein of unknown function (DUF2817)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS2_k127_6660390_8	869210.Marky_0632	4.29e-05	56.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460,F5_F8_type_C
TLS2_k127_6660390_0	1380370.JIBA01000016_gene639	2.042e-69	256.0	COG2313@1|root,COG2313@2|Bacteria,2GK19@201174|Actinobacteria,4FEJH@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
TLS2_k127_6660390_3	1894.JOER01000037_gene3070	2.778e-40	163.0	COG0524@1|root,COG0524@2|Bacteria,2GP1C@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the carbohydrate kinase PfkB family	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS2_k127_6660390_6	266117.Rxyl_1094	4.077e-18	89.0	COG2331@1|root,COG2331@2|Bacteria,2HGE7@201174|Actinobacteria,4CQV7@84995|Rubrobacteria	84995|Rubrobacteria	S	Regulatory protein, FmdB	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TLS2_k127_6660390_4	469383.Cwoe_5265	3.41e-40	166.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4CPSE@84995|Rubrobacteria	84995|Rubrobacteria	K	cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
TLS2_k127_6660390_1	469383.Cwoe_5264	3.856e-66	240.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,4CPVZ@84995|Rubrobacteria	84995|Rubrobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS2_k127_6665808_3	266117.Rxyl_1349	1.404e-59	215.0	COG1053@1|root,COG1053@2|Bacteria,2ICBE@201174|Actinobacteria,4CSY4@84995|Rubrobacteria	84995|Rubrobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
TLS2_k127_6665808_5	266117.Rxyl_1348	1.491e-42	170.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4
TLS2_k127_6665808_1	1121377.KB906418_gene3779	1.946e-127	432.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS2_k127_6665808_4	1283283.ATXA01000001_gene348	3.701e-54	194.0	COG2030@1|root,COG2030@2|Bacteria,2IK2Z@201174|Actinobacteria	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS2_k127_6665808_0	263358.VAB18032_25230	1.295e-222	710.0	COG2936@1|root,COG2936@2|Bacteria,2GJ2K@201174|Actinobacteria,4DC1G@85008|Micromonosporales	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	3.4.14.11	ko:K01281	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PepX_C,Peptidase_S15
TLS2_k127_6665808_2	1283299.AUKG01000001_gene1294	1.322e-96	319.0	COG1637@1|root,COG1637@2|Bacteria,2GIYB@201174|Actinobacteria,4CPHV@84995|Rubrobacteria	84995|Rubrobacteria	L	Endonuclease NucS	-	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
TLS2_k127_6666327_1	525904.Tter_2815	1.818e-53	196.0	COG2148@1|root,COG2148@2|Bacteria,2NP0Q@2323|unclassified Bacteria	2|Bacteria	M	Bacterial sugar transferase	rfbP	-	-	ko:K16566	-	-	-	-	ko00000	-	-	-	Bac_transf
TLS2_k127_6666327_0	1380390.JIAT01000014_gene6174	2.221e-77	269.0	COG0673@1|root,COG0673@2|Bacteria,2HPZE@201174|Actinobacteria,4CREW@84995|Rubrobacteria	84995|Rubrobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS2_k127_6678154_1	1386089.N865_14935	5.497e-39	152.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4FF1Y@85021|Intrasporangiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigH	GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6678154_3	479434.Sthe_1241	9.252e-06	51.0	COG5662@1|root,COG5662@2|Bacteria,2GA5X@200795|Chloroflexi,27ZCC@189775|Thermomicrobia	189775|Thermomicrobia	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS2_k127_6678154_4	1246448.ANAZ01000025_gene3616	4.657e-05	55.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria,4EFQT@85012|Streptosporangiales	201174|Actinobacteria	K	LytR cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
TLS2_k127_6678154_0	469383.Cwoe_2930	3.244e-57	219.0	COG2159@1|root,COG2159@2|Bacteria,2HJ7X@201174|Actinobacteria,4CPK2@84995|Rubrobacteria	84995|Rubrobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS2_k127_6678154_2	110319.CF8_1369	1.161e-12	73.0	COG1629@1|root,COG4771@2|Bacteria,2IN13@201174|Actinobacteria,4DREY@85009|Propionibacteriales	201174|Actinobacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6694627_11	1206101.AZXC01000010_gene78	1.959e-05	55.0	COG0454@1|root,COG0456@2|Bacteria,2I9GA@201174|Actinobacteria	201174|Actinobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS2_k127_6694627_5	287986.DV20_28585	6.431e-52	191.0	COG1011@1|root,COG1011@2|Bacteria,2IBB1@201174|Actinobacteria,4E7YD@85010|Pseudonocardiales	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS2_k127_6694627_0	1303518.CCALI_00236	1.177e-137	450.0	COG0304@1|root,COG0304@2|Bacteria	2|Bacteria	I	3-oxoacyl-[acyl-carrier-protein] synthase activity	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS2_k127_6694627_3	742738.HMPREF9460_00934	9.245e-75	262.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,26846@186813|unclassified Clostridiales	186801|Clostridia	IQ	Psort location Cytoplasmic, score	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS2_k127_6694627_4	411902.CLOBOL_01827	1.869e-65	250.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,247UF@186801|Clostridia,21XR4@1506553|Lachnoclostridium	186801|Clostridia	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
TLS2_k127_6694627_1	997346.HMPREF9374_0898	4.314e-106	366.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,4HATK@91061|Bacilli,27BAZ@186824|Thermoactinomycetaceae	91061|Bacilli	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
TLS2_k127_6694627_7	1123239.KB898626_gene677	2.96e-44	175.0	COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,4HGX1@91061|Bacilli	91061|Bacilli	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
TLS2_k127_6694627_10	644966.Tmar_0414	1.019e-30	140.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,3WDGI@538999|Clostridiales incertae sedis	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_6694627_8	66429.JOFL01000014_gene630	1.85e-37	151.0	COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria	201174|Actinobacteria	H	biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
TLS2_k127_6694627_6	1246995.AFR_32935	1.407e-51	211.0	COG5479@1|root,COG5479@2|Bacteria,2GNDB@201174|Actinobacteria,4DCDS@85008|Micromonosporales	201174|Actinobacteria	M	protein potentially involved in peptidoglycan biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,SpoIID,VCBS
TLS2_k127_6694627_2	309801.trd_1267	1.413e-94	326.0	COG1030@1|root,COG1030@2|Bacteria,2G6E2@200795|Chloroflexi,27XU8@189775|Thermomicrobia	189775|Thermomicrobia	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
TLS2_k127_6694627_9	42256.RradSPS_0262	1.234e-32	128.0	COG0330@1|root,COG0330@2|Bacteria,2GKFP@201174|Actinobacteria,4CPJF@84995|Rubrobacteria	84995|Rubrobacteria	O	Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS2_k127_6697015_0	935836.JAEL01000022_gene1648	2.486e-65	240.0	COG2866@1|root,COG2866@2|Bacteria,1UWIB@1239|Firmicutes,4IJTK@91061|Bacilli,1ZCG5@1386|Bacillus	91061|Bacilli	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,PA,Peptidase_M14
TLS2_k127_6697015_3	1122622.ATWJ01000010_gene1263	9.623e-07	61.0	COG0028@1|root,COG3291@1|root,COG0028@2|Bacteria,COG3291@2|Bacteria,2I5PU@201174|Actinobacteria	201174|Actinobacteria	M	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PA,Peptidase_M36
TLS2_k127_6697015_2	1090319.KE386571_gene1448	3.493e-07	61.0	COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,2TTHW@28211|Alphaproteobacteria,2KDVX@204457|Sphingomonadales	204457|Sphingomonadales	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
TLS2_k127_6697015_4	398767.Glov_1457	3.072e-06	59.0	COG3055@1|root,COG3055@2|Bacteria,1QXNG@1224|Proteobacteria,431EP@68525|delta/epsilon subdivisions,2WWPY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6697015_1	1122939.ATUD01000001_gene148	5.817e-49	193.0	COG0346@1|root,COG0346@2|Bacteria,2IIM8@201174|Actinobacteria,4CQQJ@84995|Rubrobacteria	84995|Rubrobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
TLS2_k127_6698044_4	1408444.JHYC01000013_gene2473	0.0007114	47.0	2BNP9@1|root,32HCB@2|Bacteria,1QBYA@1224|Proteobacteria,1T7JI@1236|Gammaproteobacteria,1JFGD@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6698044_1	644283.Micau_4753	1.399e-87	304.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,4DCDB@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
TLS2_k127_6698044_2	1278073.MYSTI_07186	5.836e-28	130.0	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,42TBH@68525|delta/epsilon subdivisions,2WPJ5@28221|Deltaproteobacteria,2YW2S@29|Myxococcales	28221|Deltaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
TLS2_k127_6698044_0	1380390.JIAT01000014_gene6241	3.756e-134	438.0	COG4948@1|root,COG4948@2|Bacteria,2I7AE@201174|Actinobacteria,4CPIJ@84995|Rubrobacteria	84995|Rubrobacteria	M	Mandelate Racemase Muconate Lactonizing	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6698044_3	1896.JOAU01000004_gene64	1.97e-10	61.0	COG5637@1|root,COG5637@2|Bacteria,2GMK7@201174|Actinobacteria	201174|Actinobacteria	D	cyclase dehydrase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TLS2_k127_6703539_2	926560.KE387027_gene1038	5.22e-97	330.0	COG2133@1|root,COG2133@2|Bacteria,1WJQY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS2_k127_6703539_3	1379698.RBG1_1C00001G1403	1.483e-81	284.0	COG2133@1|root,COG2133@2|Bacteria,2NNSP@2323|unclassified Bacteria	2|Bacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,GSDH
TLS2_k127_6703539_0	390989.JOEG01000010_gene561	1.752e-144	472.0	COG0477@1|root,COG2814@2|Bacteria,2I2IS@201174|Actinobacteria,4DCIJ@85008|Micromonosporales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS2_k127_6703539_4	255470.cbdbA734	1.715e-69	253.0	arCOG06481@1|root,2ZB4E@2|Bacteria,2G82Q@200795|Chloroflexi,34CXZ@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6703539_7	367299.JOEE01000003_gene2985	1.685e-18	96.0	COG0392@1|root,COG0392@2|Bacteria,2IC25@201174|Actinobacteria,4FE40@85021|Intrasporangiaceae	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	Glycos_transf_2,LPG_synthase_TM
TLS2_k127_6703539_6	525368.HMPREF0591_4078	3.817e-47	179.0	COG2114@1|root,COG2114@2|Bacteria,2IC2V@201174|Actinobacteria,237XA@1762|Mycobacteriaceae	201174|Actinobacteria	T	guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
TLS2_k127_6703539_1	525904.Tter_2416	2.632e-108	361.0	COG0861@1|root,COG0861@2|Bacteria,2NNXY@2323|unclassified Bacteria	2|Bacteria	P	Integral membrane protein TerC family	alx	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
TLS2_k127_6703539_5	1172180.KB911792_gene3733	9.57e-48	179.0	COG0517@1|root,COG0517@2|Bacteria,2GKSH@201174|Actinobacteria	201174|Actinobacteria	C	Cbs domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
TLS2_k127_6704873_0	1380390.JIAT01000014_gene6281	1.635e-225	707.0	COG1232@1|root,COG1232@2|Bacteria,2IDI5@201174|Actinobacteria,4CQXX@84995|Rubrobacteria	84995|Rubrobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS2_k127_6704873_2	469383.Cwoe_0983	8.005e-109	392.0	COG5305@1|root,COG5305@2|Bacteria,2HNMY@201174|Actinobacteria,4CPS3@84995|Rubrobacteria	84995|Rubrobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS2_k127_6704873_3	469383.Cwoe_0982	6.097e-105	384.0	COG1807@1|root,COG1807@2|Bacteria,2HJTU@201174|Actinobacteria,4CPVS@84995|Rubrobacteria	84995|Rubrobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6704873_4	469383.Cwoe_0981	2.33e-75	264.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS2_k127_6704873_1	1283299.AUKG01000002_gene4688	7.063e-117	388.0	COG1215@1|root,COG1215@2|Bacteria,2I2PK@201174|Actinobacteria,4CPE1@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS2_k127_6704873_5	1380390.JIAT01000010_gene4204	4.788e-49	201.0	COG0500@1|root,COG2226@2|Bacteria,2HNEB@201174|Actinobacteria,4CP8F@84995|Rubrobacteria	84995|Rubrobacteria	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS2_k127_6704873_7	2074.JNYD01000012_gene377	1.376e-17	93.0	COG2234@1|root,COG2234@2|Bacteria,2GIT0@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase, M28	lieA	-	3.4.11.24	ko:K19702	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	FTP,P_proprotein,Peptidase_M28,Peptidase_M4,Peptidase_M4_C
TLS2_k127_6704873_6	1128421.JAGA01000003_gene2726	5.349e-29	126.0	COG3336@1|root,COG3336@2|Bacteria	2|Bacteria	G	cytochrome c oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Caa3_CtaG
TLS2_k127_6704873_8	1250278.JQNQ01000001_gene807	0.0001569	48.0	2EHBZ@1|root,33B3U@2|Bacteria,4NZK3@976|Bacteroidetes,1I71Q@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6711587_2	429009.Adeg_1303	2.338e-95	328.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia,42EZT@68295|Thermoanaerobacterales	186801|Clostridia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS18870	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS2_k127_6711587_6	1095767.CAHD01000205_gene859	2.193e-47	197.0	COG4254@1|root,COG4733@1|root,COG4254@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	FecR,fn3
TLS2_k127_6711587_1	1380390.JIAT01000010_gene4759	6.495e-110	365.0	COG0568@1|root,COG0568@2|Bacteria,2HGMA@201174|Actinobacteria,4CR9N@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70 factor, region 1.2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_6711587_3	365528.KB891219_gene955	2.306e-93	316.0	COG1533@1|root,COG1533@2|Bacteria,2GM31@201174|Actinobacteria,4ERCS@85013|Frankiales	201174|Actinobacteria	L	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS2_k127_6711587_0	497964.CfE428DRAFT_6496	3.539e-264	827.0	COG3387@1|root,COG3387@2|Bacteria,46SD5@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
TLS2_k127_6711587_5	929712.KI912613_gene3075	1.458e-51	187.0	COG3791@1|root,COG3791@2|Bacteria,2HP2J@201174|Actinobacteria,4CQDM@84995|Rubrobacteria	84995|Rubrobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS2_k127_6711587_7	469371.Tbis_0017	3.149e-40	160.0	COG5483@1|root,COG5483@2|Bacteria,2IHSH@201174|Actinobacteria,4E4DW@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
TLS2_k127_6711587_4	1380390.JIAT01000013_gene310	5.739e-69	242.0	COG0500@1|root,COG2226@2|Bacteria,2GNTH@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS2_k127_6726025_7	710686.Mycsm_02443	2.173e-52	190.0	COG0531@1|root,COG0531@2|Bacteria,2I49Z@201174|Actinobacteria	201174|Actinobacteria	E	amino acid	-	-	-	ko:K16238	-	-	-	-	ko00000,ko02000	2.A.3.5	-	-	AA_permease,AA_permease_2
TLS2_k127_6726025_1	882083.SacmaDRAFT_1782	2.701e-160	522.0	COG0174@1|root,COG0174@2|Bacteria,2GM3K@201174|Actinobacteria,4DXD6@85010|Pseudonocardiales	201174|Actinobacteria	E	Glutamine synthetase, catalytic domain	glnA4	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
TLS2_k127_6726025_6	266117.Rxyl_3195	1.56e-67	238.0	COG2071@1|root,COG2071@2|Bacteria,2GIV6@201174|Actinobacteria,4CPYI@84995|Rubrobacteria	84995|Rubrobacteria	S	peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
TLS2_k127_6726025_0	42256.RradSPS_2749	9.369e-203	652.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4CPFP@84995|Rubrobacteria	84995|Rubrobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS2_k127_6726025_5	42256.RradSPS_2748	8.221e-102	337.0	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,4CPC2@84995|Rubrobacteria	84995|Rubrobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS2_k127_6726025_8	1380390.JIAT01000001_gene5098	2.486e-21	101.0	2AWHW@1|root,31NEF@2|Bacteria,2HR0B@201174|Actinobacteria,4CSTX@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6726025_3	1121406.JAEX01000019_gene2765	2.721e-114	391.0	COG1752@1|root,COG1752@2|Bacteria,1PGY0@1224|Proteobacteria,42MKJ@68525|delta/epsilon subdivisions,2WK4M@28221|Deltaproteobacteria,2MF8E@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
TLS2_k127_6726025_2	357808.RoseRS_0010	1.252e-114	385.0	COG0823@1|root,COG0823@2|Bacteria,2G8T5@200795|Chloroflexi,376FH@32061|Chloroflexia	32061|Chloroflexia	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
TLS2_k127_6726025_4	525904.Tter_0881	1.357e-109	367.0	COG0365@1|root,COG0365@2|Bacteria,2NNSQ@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_6726578_11	1283299.AUKG01000002_gene4205	1.467e-29	124.0	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	yxaI	-	-	-	-	-	-	-	-	-	-	-	DUF4339,RDD,zinc_ribbon_2
TLS2_k127_6726578_9	1209984.BN978_02425	4.459e-30	136.0	COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria,23A0S@1762|Mycobacteriaceae	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
TLS2_k127_6726578_5	1283299.AUKG01000001_gene1512	5.934e-58	222.0	COG0705@1|root,COG0705@2|Bacteria,2GNPK@201174|Actinobacteria,4CR15@84995|Rubrobacteria	84995|Rubrobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS2_k127_6726578_2	555088.DealDRAFT_1840	3.225e-112	370.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,42JN3@68298|Syntrophomonadaceae	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS2_k127_6726578_8	1499967.BAYZ01000171_gene5600	5.678e-31	128.0	COG0071@1|root,COG0071@2|Bacteria,2NPWF@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS2_k127_6726578_4	644966.Tmar_1470	2.227e-67	256.0	COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,2482W@186801|Clostridia,3WCY8@538999|Clostridiales incertae sedis	186801|Clostridia	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS2_k127_6726578_0	186497.PF0547	4.504e-178	587.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
TLS2_k127_6726578_3	469383.Cwoe_0781	4.295e-103	381.0	COG1164@1|root,COG1164@2|Bacteria,2HDPQ@201174|Actinobacteria,4CTTS@84995|Rubrobacteria	84995|Rubrobacteria	E	Oligoendopeptidase f	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
TLS2_k127_6726578_10	2423.NA23_0204940	1.285e-29	122.0	COG0432@1|root,COG0432@2|Bacteria,2GD2P@200918|Thermotogae	200918|Thermotogae	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TLS2_k127_6726578_7	1500259.JQLD01000002_gene3049	5.474e-34	152.0	COG2114@1|root,COG2114@2|Bacteria,1Q8YH@1224|Proteobacteria,2VD35@28211|Alphaproteobacteria,4BA5X@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
TLS2_k127_6726578_6	2002.JOEQ01000012_gene5606	1.27e-37	152.0	COG0697@1|root,COG0697@2|Bacteria,2GM50@201174|Actinobacteria,4EQYN@85012|Streptosporangiales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_6726578_1	469383.Cwoe_0782	7.559e-127	420.0	COG2265@1|root,COG2265@2|Bacteria,2GIR3@201174|Actinobacteria,4CRR6@84995|Rubrobacteria	84995|Rubrobacteria	J	tRNA (Uracil-5-)-methyltransferase	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
TLS2_k127_6728930_2	1128421.JAGA01000001_gene2004	3.294e-233	730.0	COG1523@1|root,COG1523@2|Bacteria,2NPQU@2323|unclassified Bacteria	2|Bacteria	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	glgX	-	3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS2_k127_6728930_0	1380390.JIAT01000009_gene545	4.842e-319	1015.0	COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,4CP7U@84995|Rubrobacteria	84995|Rubrobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TLS2_k127_6728930_4	1380390.JIAT01000009_gene546	4.478e-152	501.0	COG3281@1|root,COG3281@2|Bacteria,2GKAP@201174|Actinobacteria,4CPJA@84995|Rubrobacteria	84995|Rubrobacteria	G	protein, probably involved in trehalose biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS2_k127_6728930_1	298653.Franean1_1051	3.769e-272	848.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria,4EREC@85013|Frankiales	201174|Actinobacteria	G	Trehalose synthase	treS	GO:0000023,GO:0000271,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016160,GO:0016161,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046872,GO:0047471,GO:0055114,GO:0071704,GO:0071944,GO:1901576	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	iNJ661.Rv0126	Alpha-amylase,Malt_amylase_C
TLS2_k127_6728930_3	1122939.ATUD01000004_gene3931	3.245e-227	718.0	COG0366@1|root,COG0366@2|Bacteria,2GJKR@201174|Actinobacteria,4CP80@84995|Rubrobacteria	84995|Rubrobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
TLS2_k127_6728930_5	1122939.ATUD01000004_gene3930	3.805e-141	460.0	COG1640@1|root,COG1640@2|Bacteria,2GM5Z@201174|Actinobacteria,4CPER@84995|Rubrobacteria	84995|Rubrobacteria	G	4-alpha-glucanotransferase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
TLS2_k127_6728930_6	1123321.KB905822_gene3813	4.678e-53	198.0	COG4447@1|root,COG4447@2|Bacteria,2GN53@201174|Actinobacteria	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
TLS2_k127_6728930_7	28444.JODQ01000002_gene4608	2.082e-45	168.0	COG2374@1|root,COG2374@2|Bacteria,2GPQN@201174|Actinobacteria	201174|Actinobacteria	S	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6734191_2	1068978.AMETH_5298	1.386e-66	231.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4E20H@85010|Pseudonocardiales	201174|Actinobacteria	P	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS2_k127_6734191_0	457429.ABJI02000385_gene4491	2.461e-162	528.0	COG2197@1|root,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS2_k127_6734191_1	1122138.AQUZ01000019_gene8187	3.35e-141	462.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4DNJC@85009|Propionibacteriales	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS2_k127_6747608_1	469383.Cwoe_5905	1.651e-91	306.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4CU2Q@84995|Rubrobacteria	84995|Rubrobacteria	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_6747608_17	272558.10176486	2.918e-05	57.0	COG2234@1|root,COG2234@2|Bacteria,1UFM1@1239|Firmicutes,4HBE5@91061|Bacilli,1ZC0A@1386|Bacillus	91061|Bacilli	S	PA domain	ywaD	-	3.4.11.10,3.4.11.6	ko:K19701	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28
TLS2_k127_6747608_4	469383.Cwoe_4686	3.237e-75	287.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4CQ5A@84995|Rubrobacteria	84995|Rubrobacteria	H	molybdopterin binding domain	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS2_k127_6747608_0	266117.Rxyl_2308	7.307e-128	454.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4CPUU@84995|Rubrobacteria	84995|Rubrobacteria	M	glycosyl transferase, family 51	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS2_k127_6747608_12	469383.Cwoe_5898	3.875e-25	119.0	COG0668@1|root,COG0668@2|Bacteria,2GJ51@201174|Actinobacteria	201174|Actinobacteria	M	mechanosensitive ion channel	mscS	-	-	-	-	-	-	-	-	-	-	-	MS_channel
TLS2_k127_6747608_14	795797.C497_14492	1.271e-18	98.0	COG0614@1|root,arCOG04233@2157|Archaea,2XUJY@28890|Euryarchaeota,23TU0@183963|Halobacteria	183963|Halobacteria	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	btuF	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS2_k127_6747608_11	1380390.JIAT01000009_gene1871	6.318e-27	119.0	COG1011@1|root,COG1011@2|Bacteria,2HPG7@201174|Actinobacteria,4CQUS@84995|Rubrobacteria	84995|Rubrobacteria	S	HAD-superfamily hydrolase, subfamily IA, variant	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
TLS2_k127_6747608_2	880073.Calab_2940	9.619e-90	317.0	COG0626@1|root,COG0626@2|Bacteria,2NNNS@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	-	-	4.4.1.11,4.4.1.8	ko:K01760,ko:K01761	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R00654,R00782,R01286,R02408,R04770,R04941	RC00056,RC00069,RC00196,RC00348,RC00382,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS2_k127_6747608_16	1123070.KB899249_gene301	3.404e-12	76.0	COG1266@1|root,COG1266@2|Bacteria,46T6D@74201|Verrucomicrobia,2IUVK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS2_k127_6747608_10	469371.Tbis_1348	6.167e-27	124.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2HU8H@201174|Actinobacteria,4EDMS@85010|Pseudonocardiales	201174|Actinobacteria	M	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
TLS2_k127_6747608_15	1121920.AUAU01000005_gene1012	1.709e-17	85.0	COG1605@1|root,COG1605@2|Bacteria	2|Bacteria	E	Chorismate mutase	aroA	-	2.5.1.54,5.4.99.5	ko:K03856,ko:K04092,ko:K04093,ko:K04516,ko:K13853	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022,M00024,M00025	R01715,R01826	RC00435,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,DAHP_synth_1
TLS2_k127_6747608_5	469383.Cwoe_5941	1.076e-70	242.0	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,4CQ04@84995|Rubrobacteria	84995|Rubrobacteria	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
TLS2_k127_6747608_13	395961.Cyan7425_1430	2.012e-22	101.0	2CEFP@1|root,2ZGIZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6747608_6	1235835.C814_02936	1.157e-56	211.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,3WHV1@541000|Ruminococcaceae	186801|Clostridia	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
TLS2_k127_6747608_3	1122939.ATUD01000013_gene896	5.539e-77	274.0	COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4CQ24@84995|Rubrobacteria	84995|Rubrobacteria	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS2_k127_6747608_8	429009.Adeg_2147	4.803e-30	136.0	COG0357@1|root,COG0357@2|Bacteria,1W6WG@1239|Firmicutes,25MN8@186801|Clostridia,42IXD@68295|Thermoanaerobacterales	186801|Clostridia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
TLS2_k127_6747608_7	768710.DesyoDRAFT_5454	5.923e-33	138.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,260UK@186807|Peptococcaceae	186801|Clostridia	S	PFAM Single-stranded nucleic acid binding R3H	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
TLS2_k127_6747608_9	1380390.JIAT01000009_gene1795	3.385e-28	121.0	COG0706@1|root,COG0706@2|Bacteria,2GJBU@201174|Actinobacteria,4CPXT@84995|Rubrobacteria	84995|Rubrobacteria	U	60Kd inner membrane protein	-	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
TLS2_k127_6747644_0	469383.Cwoe_1327	4.591e-271	845.0	COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria,4CPMH@84995|Rubrobacteria	84995|Rubrobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
TLS2_k127_6747644_2	1120956.JHZK01000045_gene1826	1.612e-37	154.0	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2U9FX@28211|Alphaproteobacteria,1JP3Q@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
TLS2_k127_6747644_3	1179773.BN6_79650	2.09e-31	133.0	COG0244@1|root,COG0244@2|Bacteria,2GM0V@201174|Actinobacteria,4E0K2@85010|Pseudonocardiales	201174|Actinobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
TLS2_k127_6747644_1	1380390.JIAT01000011_gene2556	3.11e-89	298.0	COG0081@1|root,COG0081@2|Bacteria,2GM51@201174|Actinobacteria,4CPV5@84995|Rubrobacteria	84995|Rubrobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
TLS2_k127_6758799_1	448385.sce2947	1.063e-14	84.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,2YY2P@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
TLS2_k127_6758799_0	1089553.Tph_c04840	1.472e-48	187.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,42JDU@68295|Thermoanaerobacterales	186801|Clostridia	K	Response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_6758799_2	446466.Cfla_3376	5.303e-09	58.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase type 11	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
TLS2_k127_6776782_6	469383.Cwoe_4339	1.417e-07	61.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4CRWC@84995|Rubrobacteria	84995|Rubrobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS2_k127_6776782_2	649638.Trad_1690	4.178e-73	263.0	COG1250@1|root,COG1250@2|Bacteria,1WIN8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS2_k127_6776782_1	383372.Rcas_1067	9.301e-77	261.0	COG0259@1|root,COG0259@2|Bacteria,2G8DA@200795|Chloroflexi,376ZA@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	-	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
TLS2_k127_6776782_3	555088.DealDRAFT_0002	1.28e-70	246.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,42KCR@68298|Syntrophomonadaceae	186801|Clostridia	K	response regulator receiver	-	-	-	ko:K07668,ko:K07775	ko02020,map02020	M00458,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_6776782_4	235909.GK2373	6.659e-48	189.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HANF@91061|Bacilli,1WERY@129337|Geobacillus	91061|Bacilli	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_6776782_0	266117.Rxyl_1329	7.031e-97	334.0	COG0809@1|root,COG0809@2|Bacteria,2GN51@201174|Actinobacteria	201174|Actinobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
TLS2_k127_6776782_5	190650.CC_2610	1.182e-34	147.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2KIWU@204458|Caulobacterales	204458|Caulobacterales	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS2_k127_6784110_4	1313172.YM304_01230	0.0001629	52.0	COG3409@1|root,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	ko:K03791	-	-	-	-	ko00000	-	GH19	-	PG_binding_1
TLS2_k127_6784110_1	593750.Metfor_2049	2.725e-69	249.0	COG4294@1|root,arCOG01898@2157|Archaea,2XVT2@28890|Euryarchaeota	28890|Euryarchaeota	L	UV-endonuclease UvdE	uvsE	-	-	ko:K13281	-	-	-	-	ko00000,ko01000	-	-	-	UvdE
TLS2_k127_6784110_0	1121272.KB903249_gene1636	9.204e-140	454.0	COG4805@1|root,COG4805@2|Bacteria,2GJQT@201174|Actinobacteria,4DENJ@85008|Micromonosporales	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6784110_2	452637.Oter_3673	8.262e-25	115.0	COG2982@1|root,COG2982@2|Bacteria,46XH6@74201|Verrucomicrobia,3KA1C@414999|Opitutae	414999|Opitutae	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6784110_3	479435.Kfla_0799	1.229e-14	75.0	2C7GR@1|root,32H51@2|Bacteria,2IPDA@201174|Actinobacteria,4DVC4@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_68288_3	235985.BBPN01000064_gene7403	3.69e-10	72.0	COG1520@1|root,COG1520@2|Bacteria,2I9FJ@201174|Actinobacteria	201174|Actinobacteria	M	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Big_3_5,LGFP,PQQ_2,PQQ_3
TLS2_k127_68288_4	1157635.KB892011_gene1205	2.612e-05	57.0	COG0823@1|root,COG2304@1|root,COG0823@2|Bacteria,COG2304@2|Bacteria,2GMNT@201174|Actinobacteria	201174|Actinobacteria	U	Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	HYR,PD40,VWA
TLS2_k127_68288_1	66869.JNXG01000011_gene228	2.585e-23	115.0	COG0070@1|root,COG0070@2|Bacteria,2IB5W@201174|Actinobacteria	201174|Actinobacteria	E	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6839424_11	1463936.JOJI01000015_gene6783	1.183e-06	53.0	COG3663@1|root,COG3663@2|Bacteria,2GNS5@201174|Actinobacteria	201174|Actinobacteria	L	DNA glycosylase	mug	-	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS2_k127_6839424_5	1032480.MLP_11570	4.299e-83	298.0	COG1044@1|root,COG1044@2|Bacteria,2IH85@201174|Actinobacteria,4DQS4@85009|Propionibacteriales	201174|Actinobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S55
TLS2_k127_6839424_12	67373.JOBF01000024_gene6905	0.0007536	51.0	COG1764@1|root,COG1764@2|Bacteria,2IHT2@201174|Actinobacteria	201174|Actinobacteria	O	PFAM OsmC family protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,OsmC
TLS2_k127_6839424_1	469383.Cwoe_3480	7.974e-193	617.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2GK2C@201174|Actinobacteria,4CQ32@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
TLS2_k127_6839424_8	234267.Acid_5930	9.111e-53	202.0	COG1028@1|root,COG1028@2|Bacteria	234267.Acid_5930|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6839424_0	886293.Sinac_1689	8.373e-242	765.0	COG0365@1|root,COG0365@2|Bacteria,2IX5P@203682|Planctomycetes	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acs	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS2_k127_6839424_3	266940.Krad_2862	3.889e-119	392.0	COG0464@1|root,COG0464@2|Bacteria,2GJWA@201174|Actinobacteria	201174|Actinobacteria	O	AAA ATPase central domain protein	eccA1	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019725,GO:0030003,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033212,GO:0033214,GO:0033554,GO:0040007,GO:0042592,GO:0042594,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051704,GO:0051716,GO:0055065,GO:0055069,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0071944,GO:0072507,GO:0098771	-	-	-	-	-	-	-	-	-	-	AAA
TLS2_k127_6839424_2	1283299.AUKG01000002_gene4371	1.625e-123	411.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4CRH0@84995|Rubrobacteria	84995|Rubrobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_6839424_10	644966.Tmar_1853	7.253e-19	102.0	COG1309@1|root,COG1309@2|Bacteria,1V4AJ@1239|Firmicutes	1239|Firmicutes	K	Transcriptional regulator	betI1	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS2_k127_6839424_9	1298880.AUEV01000002_gene1752	1.57e-19	102.0	COG1396@1|root,COG1396@2|Bacteria,2GNQ9@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31,TPR_12,TPR_16,TPR_8
TLS2_k127_6839424_4	1382306.JNIM01000001_gene3473	9.052e-110	361.0	COG2897@1|root,COG2897@2|Bacteria,2G5XI@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Rhodanese domain protein	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS2_k127_6839424_6	479434.Sthe_2593	1.031e-79	276.0	COG1834@1|root,COG1834@2|Bacteria,2G7QT@200795|Chloroflexi,27YZU@189775|Thermomicrobia	189775|Thermomicrobia	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
TLS2_k127_6839424_7	1128421.JAGA01000002_gene1133	2.258e-54	202.0	COG0709@1|root,COG0709@2|Bacteria,2NNUD@2323|unclassified Bacteria	2|Bacteria	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C,Pyr_redox_2
TLS2_k127_6854894_4	710111.FraQA3DRAFT_0932	4.682e-26	117.0	COG4097@1|root,COG4097@2|Bacteria,2GQH2@201174|Actinobacteria,4EW08@85013|Frankiales	201174|Actinobacteria	P	PFAM Ferric reductase domain protein transmembrane component domain	-	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
TLS2_k127_6854894_6	103733.JNYO01000048_gene8440	4.235e-05	54.0	COG1141@1|root,COG1141@2|Bacteria,2HS40@201174|Actinobacteria,4ECAT@85010|Pseudonocardiales	201174|Actinobacteria	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6854894_1	2074.JNYD01000058_gene3325	1.952e-94	332.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4DX7B@85010|Pseudonocardiales	201174|Actinobacteria	S	Reductase C-terminal	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
TLS2_k127_6854894_0	42256.RradSPS_0938	3.402e-123	408.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria,4CPQF@84995|Rubrobacteria	84995|Rubrobacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS2_k127_6854894_2	1463820.JOGW01000016_gene5132	1.412e-56	203.0	2DB76@1|root,2Z7JZ@2|Bacteria,2GKK0@201174|Actinobacteria	201174|Actinobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
TLS2_k127_6854894_3	717605.Theco_1403	8.742e-37	141.0	COG0276@1|root,COG0276@2|Bacteria,1TPKF@1239|Firmicutes,4HAYG@91061|Bacilli,26SGK@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
TLS2_k127_6882017_5	446468.Ndas_3515	3.665e-07	60.0	COG0815@1|root,COG0815@2|Bacteria,2GP8X@201174|Actinobacteria,4EMQA@85012|Streptosporangiales	201174|Actinobacteria	M	Carbon-nitrogen hydrolase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
TLS2_k127_6882017_2	469383.Cwoe_3214	8.397e-48	196.0	COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria,4CQFZ@84995|Rubrobacteria	84995|Rubrobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
TLS2_k127_6882017_4	1283287.KB822576_gene3785	1.521e-24	121.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4DNDP@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS2_k127_6882017_0	2074.JNYD01000003_gene4020	6.929e-108	358.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4DYG2@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM ATPase family associated with various cellular activities (AAA)	yeaC	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS2_k127_6882017_1	469383.Cwoe_3211	1.125e-99	342.0	COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria,4CQAJ@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TLS2_k127_6882017_3	469383.Cwoe_3210	7.016e-25	105.0	COG1758@1|root,COG1758@2|Bacteria,2IQHU@201174|Actinobacteria,4CQGS@84995|Rubrobacteria	84995|Rubrobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
TLS2_k127_6885545_9	36630.CADNFIAP00004603	6.895e-39	147.0	2CUWZ@1|root,2RPHZ@2759|Eukaryota,38T8H@33154|Opisthokonta,3PUXW@4751|Fungi,3RE5V@4890|Ascomycota,20QP4@147545|Eurotiomycetes,3SDCI@5042|Eurotiales	4751|Fungi	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS2_k127_6885545_8	1380391.JIAS01000015_gene178	1.124e-44	177.0	2E1J9@1|root,32WWY@2|Bacteria,1Q7D3@1224|Proteobacteria,2UTHG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6885545_5	1278073.MYSTI_02090	2.015e-69	239.0	2D579@1|root,32TID@2|Bacteria,1RH2N@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6885545_3	1283299.AUKG01000002_gene4314	7.494e-87	302.0	COG2378@1|root,COG2378@2|Bacteria,2GKTS@201174|Actinobacteria,4CR83@84995|Rubrobacteria	84995|Rubrobacteria	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
TLS2_k127_6885545_12	746697.Aeqsu_2184	1.937e-06	60.0	COG2972@1|root,COG2972@2|Bacteria,4NFDP@976|Bacteroidetes,1HWNJ@117743|Flavobacteriia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	2TM,His_kinase
TLS2_k127_6885545_0	1137271.AZUM01000008_gene2089	1.969e-150	486.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4DY4T@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA primase, small subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6885545_10	1123319.AUBE01000001_gene1983	2.84e-27	114.0	2AYDD@1|root,31QGA@2|Bacteria,2IS2F@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS2_k127_6885545_6	469383.Cwoe_5336	7.229e-66	231.0	COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,4CQJI@84995|Rubrobacteria	84995|Rubrobacteria	S	Haemolysin-III related	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
TLS2_k127_6885545_7	635013.TherJR_2378	2.082e-53	203.0	COG1752@1|root,COG1752@2|Bacteria,1TRJW@1239|Firmicutes,248J0@186801|Clostridia	186801|Clostridia	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS2_k127_6885545_4	1122609.AUGT01000018_gene143	2.325e-84	289.0	COG0834@1|root,COG0834@2|Bacteria,2GN3G@201174|Actinobacteria,4DNI8@85009|Propionibacteriales	201174|Actinobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030,ko:K02424,ko:K17073	ko02010,map02010	M00234,M00236,M00589	-	-	ko00000,ko00001,ko00002,ko02000,ko02035	3.A.1.3,3.A.1.3.10,3.A.1.3.14,3.A.1.3.20	-	-	SBP_bac_3
TLS2_k127_6885545_2	1122611.KB903955_gene5556	9.998e-98	327.0	COG0765@1|root,COG0765@2|Bacteria,2GM0I@201174|Actinobacteria,4EGKS@85012|Streptosporangiales	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1,DUF2808,SBP_bac_3
TLS2_k127_6885545_1	1380347.JNII01000005_gene3721	4.781e-98	339.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4ES6N@85013|Frankiales	201174|Actinobacteria	E	PFAM ABC transporter	-	-	3.6.3.21	ko:K02028,ko:K02029,ko:K10008	ko02010,map02010	M00233,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.9	-	-	ABC_tran,BPD_transp_1
TLS2_k127_6885545_11	751945.Theos_2169	4.452e-08	56.0	COG2905@1|root,COG2905@2|Bacteria,1WJV4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_68967_8	1380390.JIAT01000009_gene1527	9.767e-50	201.0	COG1573@1|root,COG1573@2|Bacteria,2HNTA@201174|Actinobacteria,4CQ1J@84995|Rubrobacteria	84995|Rubrobacteria	L	Uracil DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
TLS2_k127_68967_5	469383.Cwoe_0789	5.716e-99	352.0	COG0438@1|root,COG0613@1|root,COG0438@2|Bacteria,COG0613@2|Bacteria,2HPUE@201174|Actinobacteria,4CR88@84995|Rubrobacteria	84995|Rubrobacteria	M	PHP-associated	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,PHP,PHP_C
TLS2_k127_68967_0	1122138.AQUZ01000019_gene8148	2.246e-292	929.0	COG3227@1|root,COG3227@2|Bacteria,2GMQS@201174|Actinobacteria,4DN9H@85009|Propionibacteriales	2|Bacteria	E	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M36
TLS2_k127_68967_6	526225.Gobs_1475	8.749e-72	257.0	COG1878@1|root,COG1878@2|Bacteria,2GNFV@201174|Actinobacteria,4EVRM@85013|Frankiales	201174|Actinobacteria	S	PFAM cyclase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS2_k127_68967_2	1128421.JAGA01000003_gene3158	3.406e-175	561.0	COG1260@1|root,COG1260@2|Bacteria,2NNVE@2323|unclassified Bacteria	2|Bacteria	I	Myo-inositol-1-phosphate synthase	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
TLS2_k127_68967_10	929712.KI912613_gene1804	6.678e-28	123.0	COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4CQHA@84995|Rubrobacteria	84995|Rubrobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS2_k127_68967_9	1283299.AUKG01000001_gene1467	3.81e-36	146.0	COG0671@1|root,COG0671@2|Bacteria,2GMYU@201174|Actinobacteria,4CRYZ@84995|Rubrobacteria	84995|Rubrobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
TLS2_k127_68967_4	1382306.JNIM01000001_gene1906	1.728e-136	449.0	COG2896@1|root,COG2896@2|Bacteria,2G5JT@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
TLS2_k127_68967_1	469371.Tbis_0825	4.884e-192	616.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4DYZ1@85010|Pseudonocardiales	201174|Actinobacteria	M	Gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS2_k127_68967_7	1134445.AJJM01000108_gene3975	2.017e-58	216.0	COG0697@1|root,COG0697@2|Bacteria,2I91Y@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_68967_3	1380347.JNII01000005_gene3086	5.523e-137	450.0	COG1982@1|root,COG1982@2|Bacteria,2GJ31@201174|Actinobacteria	201174|Actinobacteria	E	Orn Lys Arg decarboxylase	-	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
TLS2_k127_68967_11	428125.CLOLEP_00078	7.672e-19	87.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,3WGES@541000|Ruminococcaceae	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TLS2_k127_691406_2	266117.Rxyl_1606	9.516e-96	319.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,4CPHA@84995|Rubrobacteria	84995|Rubrobacteria	D	ATPases associated with a variety of cellular activities	-	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
TLS2_k127_691406_5	469383.Cwoe_4586	3.922e-48	183.0	COG2177@1|root,COG2177@2|Bacteria,2GJMA@201174|Actinobacteria,4CPSH@84995|Rubrobacteria	84995|Rubrobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
TLS2_k127_691406_3	469383.Cwoe_4584	9.084e-66	240.0	COG0793@1|root,COG0793@2|Bacteria,2GKRP@201174|Actinobacteria,4CPMI@84995|Rubrobacteria	84995|Rubrobacteria	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
TLS2_k127_691406_0	469383.Cwoe_4583	3.471e-141	484.0	COG0557@1|root,COG0557@2|Bacteria,2GNSM@201174|Actinobacteria,4CPE0@84995|Rubrobacteria	84995|Rubrobacteria	K	RNB	-	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
TLS2_k127_691406_1	469383.Cwoe_4746	1.651e-115	387.0	COG0346@1|root,COG0346@2|Bacteria,2IAYN@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_691406_4	65497.JODV01000001_gene3676	7.554e-53	190.0	COG0691@1|root,COG0691@2|Bacteria,2GJX1@201174|Actinobacteria,4E2R0@85010|Pseudonocardiales	201174|Actinobacteria	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
TLS2_k127_6946112_0	574087.Acear_1875	1.914e-117	387.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,3WA77@53433|Halanaerobiales	186801|Clostridia	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS2_k127_6946112_5	935866.JAER01000001_gene2657	5.286e-07	60.0	2B2YE@1|root,31VJA@2|Bacteria,2IMKP@201174|Actinobacteria,4DV0J@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6946112_3	1283299.AUKG01000001_gene1832	1.859e-27	117.0	COG0361@1|root,COG0361@2|Bacteria,2IQ4B@201174|Actinobacteria,4CQCQ@84995|Rubrobacteria	84995|Rubrobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
TLS2_k127_6946112_1	469383.Cwoe_0896	1.668e-41	165.0	COG0739@1|root,COG3409@1|root,COG0739@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	nlpD	-	-	-	-	-	-	-	-	-	-	-	G5,LysM,PG_binding_1,Peptidase_M23
TLS2_k127_6946112_4	479434.Sthe_3506	6.908e-21	104.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2G7EW@200795|Chloroflexi	200795|Chloroflexi	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM,SLT
TLS2_k127_6946112_2	469383.Cwoe_3000	3.05e-29	121.0	COG3324@1|root,COG3324@2|Bacteria,2GPAS@201174|Actinobacteria	201174|Actinobacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS2_k127_6946112_6	316067.Geob_1283	0.0005817	44.0	COG1361@1|root,COG1404@1|root,COG3210@1|root,COG4625@1|root,COG4886@1|root,COG1361@2|Bacteria,COG1404@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria,COG4886@2|Bacteria,1QUXB@1224|Proteobacteria	1224|Proteobacteria	U	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin_3,DUF11,DUF4347,He_PIG,PATR
TLS2_k127_6999299_3	1121019.AUMN01000005_gene2719	3.192e-85	303.0	COG0665@1|root,COG0665@2|Bacteria,2GMR7@201174|Actinobacteria	201174|Actinobacteria	E	D-amino acid	-	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO
TLS2_k127_6999299_2	1123507.ATVQ01000004_gene2425	4.222e-91	307.0	COG1335@1|root,COG1335@2|Bacteria,2I8U4@201174|Actinobacteria,1WAEW@1268|Micrococcaceae	201174|Actinobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS2_k127_6999299_1	1380390.JIAT01000010_gene4281	4.17e-103	342.0	COG1191@1|root,COG1191@2|Bacteria,2GKBK@201174|Actinobacteria,4CQ8F@84995|Rubrobacteria	84995|Rubrobacteria	K	RNA polymerase sigma factor	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS2_k127_6999299_0	264732.Moth_1142	4.05e-199	641.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia,42FPS@68295|Thermoanaerobacterales	186801|Clostridia	J	TIGRFAM Translation elongation factor	fusA2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS2_k127_6999299_6	469383.Cwoe_3662	3.881e-19	96.0	2AT5U@1|root,31IN3@2|Bacteria,2HN2Z@201174|Actinobacteria,4CQH5@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6999299_8	1283299.AUKG01000002_gene4776	1.31e-14	78.0	2B9E0@1|root,322RT@2|Bacteria,2HRVF@201174|Actinobacteria,4CTYV@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_6999299_5	316274.Haur_4664	1.618e-61	233.0	COG0642@1|root,COG2205@2|Bacteria,2GBIY@200795|Chloroflexi	200795|Chloroflexi	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS2_k127_6999299_4	358823.DF19_31775	2.341e-75	258.0	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	resD	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS2_k127_7000276_4	1380390.JIAT01000010_gene4224	8.491e-46	171.0	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4CQ9U@84995|Rubrobacteria	84995|Rubrobacteria	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
TLS2_k127_7000276_2	1283299.AUKG01000002_gene4708	1.202e-51	196.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4CQ3G@84995|Rubrobacteria	84995|Rubrobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS2_k127_7000276_1	929712.KI912613_gene4214	1.397e-58	207.0	COG0711@1|root,COG0711@2|Bacteria,2HNZ4@201174|Actinobacteria,4CQ8B@84995|Rubrobacteria	84995|Rubrobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7000276_5	469383.Cwoe_3693	7.312e-34	138.0	COG1399@1|root,COG1399@2|Bacteria,2HQSM@201174|Actinobacteria,4CSGR@84995|Rubrobacteria	84995|Rubrobacteria	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
TLS2_k127_7000276_8	867903.ThesuDRAFT_00311	2.311e-21	94.0	COG0333@1|root,COG0333@2|Bacteria,1VEFI@1239|Firmicutes,24QM0@186801|Clostridia,3WCP9@538999|Clostridiales incertae sedis	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
TLS2_k127_7000276_0	1121472.AQWN01000002_gene2329	1.468e-81	284.0	COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia,2610G@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
TLS2_k127_7000276_7	1229520.ADIAL_0348	1.925e-21	96.0	COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,4HNQ0@91061|Bacilli,27GQC@186828|Carnobacteriaceae	91061|Bacilli	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS2_k127_7000276_3	469383.Cwoe_3689	4.424e-48	186.0	COG0571@1|root,COG0571@2|Bacteria,2GKER@201174|Actinobacteria,4CPZ4@84995|Rubrobacteria	84995|Rubrobacteria	K	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
TLS2_k127_7000276_6	1380390.JIAT01000009_gene661	1.653e-27	114.0	COG3629@1|root,COG3629@2|Bacteria,2IBMM@201174|Actinobacteria,4CTN8@84995|Rubrobacteria	84995|Rubrobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
TLS2_k127_7001060_7	1122939.ATUD01000021_gene4056	1.611e-09	61.0	2AXD0@1|root,31PCB@2|Bacteria,2HRSN@201174|Actinobacteria,4CTVR@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7001060_0	1449126.JQKL01000028_gene2582	4.552e-66	236.0	COG1273@1|root,COG1273@2|Bacteria,1TSY5@1239|Firmicutes,249R4@186801|Clostridia	186801|Clostridia	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
TLS2_k127_7001060_4	86416.Clopa_0202	2.844e-39	160.0	COG0791@1|root,COG3883@1|root,COG0791@2|Bacteria,COG3883@2|Bacteria,1UVYK@1239|Firmicutes,249G6@186801|Clostridia,36FW2@31979|Clostridiaceae	186801|Clostridia	M	NLP P60 protein	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SH3_3
TLS2_k127_7001060_5	1341151.ASZU01000004_gene299	7.05e-19	102.0	COG3584@1|root,COG3584@2|Bacteria,1TTIK@1239|Firmicutes,4HC79@91061|Bacilli,27AX9@186824|Thermoactinomycetaceae	91061|Bacilli	S	G5	yabE	-	-	-	-	-	-	-	-	-	-	-	3D,DUF348,G5
TLS2_k127_7001060_1	469383.Cwoe_2525	6.507e-64	227.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_7001060_3	1380390.JIAT01000011_gene2625	1.276e-45	188.0	COG2027@1|root,COG2027@2|Bacteria,2GJPH@201174|Actinobacteria,4CQ4E@84995|Rubrobacteria	84995|Rubrobacteria	M	D-Ala-D-Ala carboxypeptidase 3 (S13) family	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
TLS2_k127_7001060_6	1123248.KB893317_gene4276	1.761e-12	79.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes	976|Bacteroidetes	EU	Peptidase, S9A B C family, catalytic domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS2_k127_7001060_2	1128421.JAGA01000002_gene1815	4.426e-60	215.0	COG0272@1|root,COG0272@2|Bacteria,2NNSW@2323|unclassified Bacteria	2|Bacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
TLS2_k127_7052299_4	1459636.NTE_02653	7.559e-23	103.0	COG0822@1|root,arCOG02077@2157|Archaea,41SPT@651137|Thaumarchaeota	651137|Thaumarchaeota	C	SUF system FeS assembly protein	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS2_k127_7052299_0	1110502.TMO_0108	1.257e-141	461.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2TRNY@28211|Alphaproteobacteria,2JPRG@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
TLS2_k127_7052299_3	1283299.AUKG01000001_gene1832	1.2e-29	121.0	COG0361@1|root,COG0361@2|Bacteria,2IQ4B@201174|Actinobacteria,4CQCQ@84995|Rubrobacteria	84995|Rubrobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
TLS2_k127_7052299_5	710686.Mycsm_00748	5.062e-19	101.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria,23AKA@1762|Mycobacteriaceae	201174|Actinobacteria	K	Cold-shock	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS2_k127_7052299_1	469383.Cwoe_5393	5.32e-92	311.0	COG0719@1|root,COG0719@2|Bacteria,2GJNV@201174|Actinobacteria,4CQXR@84995|Rubrobacteria	84995|Rubrobacteria	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
TLS2_k127_7089285_8	1380390.JIAT01000009_gene408	3.627e-24	114.0	COG0697@1|root,COG0697@2|Bacteria,2GMPU@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS2_k127_7089285_6	469383.Cwoe_3182	1.623e-41	157.0	COG3829@1|root,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,HATPase_c,HisKA,HisKA_2,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS2_k127_7089285_1	525904.Tter_1226	2.042e-113	393.0	COG0492@1|root,COG0492@2|Bacteria,2NNS7@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913	Pyr_redox_2
TLS2_k127_7089285_7	479434.Sthe_1024	1.549e-24	117.0	COG1503@1|root,COG1503@2|Bacteria,2G745@200795|Chloroflexi,27XGI@189775|Thermomicrobia	189775|Thermomicrobia	J	translation release factor activity	-	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_2
TLS2_k127_7089285_3	247490.KSU1_C0355	8.779e-106	357.0	COG1322@1|root,COG1322@2|Bacteria,2J2TY@203682|Planctomycetes	203682|Planctomycetes	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
TLS2_k127_7089285_4	1242864.D187_000580	4.75e-83	286.0	COG0388@1|root,COG0388@2|Bacteria,1MWQG@1224|Proteobacteria,42RTY@68525|delta/epsilon subdivisions,2WNFS@28221|Deltaproteobacteria,2YTYI@29|Myxococcales	28221|Deltaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.5.1	ko:K01501	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
TLS2_k127_7089285_9	1128421.JAGA01000002_gene219	6.819e-17	90.0	COG3415@1|root,COG3415@2|Bacteria,2NPY9@2323|unclassified Bacteria	2|Bacteria	L	Protein of unknown function (DUF3105)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
TLS2_k127_7089285_10	342949.PNA2_0096	1.425e-09	63.0	COG1030@1|root,arCOG01910@2157|Archaea,2XW1R@28890|Euryarchaeota,242U5@183968|Thermococci	183968|Thermococci	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
TLS2_k127_7089285_0	1121939.L861_05845	4.621e-131	434.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS2_k127_7089285_2	479432.Sros_5689	7.474e-109	360.0	COG5006@1|root,COG5006@2|Bacteria,2GJKB@201174|Actinobacteria,4EGE7@85012|Streptosporangiales	201174|Actinobacteria	S	EamA-like transporter family	-	-	-	ko:K11939	-	-	-	-	ko00000,ko02000	2.A.7.3.6	-	-	EamA
TLS2_k127_7089285_5	479432.Sros_5688	1.228e-53	197.0	COG1522@1|root,COG1522@2|Bacteria,2IFSQ@201174|Actinobacteria,4ENX2@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS2_k127_7089285_11	469383.Cwoe_5209	1.348e-08	57.0	COG0248@1|root,COG0248@2|Bacteria,2GJBN@201174|Actinobacteria,4CPJE@84995|Rubrobacteria	84995|Rubrobacteria	FP	Ppx/GppA phosphatase family	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
TLS2_k127_7133671_0	697281.Mahau_0939	1.67e-165	530.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,42F68@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TLS2_k127_7133671_3	1324957.K933_08073	1.063e-27	126.0	COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,23SEE@183963|Halobacteria	183963|Halobacteria	J	Sua5 YciO YrdC YwlC family protein	yrdC	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
TLS2_k127_7133671_1	1121324.CLIT_20c00320	1.456e-85	305.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia,25QHU@186804|Peptostreptococcaceae	186801|Clostridia	E	ABC transporter, ATP-binding protein	glnQ	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
TLS2_k127_7133671_2	42256.RradSPS_2523	6.885e-43	169.0	COG0765@1|root,COG0765@2|Bacteria,2GJJ9@201174|Actinobacteria,4CU2C@84995|Rubrobacteria	84995|Rubrobacteria	P	Amino acid ABC transporter, permease protein, 3-TM	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
TLS2_k127_7147099_2	1048339.KB913029_gene788	4.452e-08	57.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,PAP2
TLS2_k127_7147099_1	570967.JMLV01000014_gene2004	3.735e-22	100.0	COG2905@1|root,COG2905@2|Bacteria,1N7MU@1224|Proteobacteria,2UGVF@28211|Alphaproteobacteria,2JYZN@204441|Rhodospirillales	204441|Rhodospirillales	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS2_k127_7147099_0	469383.Cwoe_4781	1.78e-138	455.0	COG0477@1|root,COG2271@1|root,COG0477@2|Bacteria,COG2271@2|Bacteria,2I31V@201174|Actinobacteria,4CPF3@84995|Rubrobacteria	201174|Actinobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS2_k127_7155039_8	1123023.JIAI01000001_gene7376	6.238e-08	55.0	COG0726@1|root,COG0726@2|Bacteria,2GM0X@201174|Actinobacteria	201174|Actinobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS2_k127_7155039_1	582899.Hden_1713	1.14e-74	256.0	COG2514@1|root,COG2514@2|Bacteria,1RBC7@1224|Proteobacteria,2U5JP@28211|Alphaproteobacteria,3N7EV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Glyoxalase-like domain	catE	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
TLS2_k127_7155039_6	1283299.AUKG01000002_gene5312	1.46e-22	111.0	COG0640@1|root,COG0640@2|Bacteria,2HRDI@201174|Actinobacteria,4CTBB@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS2_k127_7155039_4	1283299.AUKG01000002_gene5309	1.456e-29	127.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS2_k127_7155039_5	1206101.AZXC01000013_gene934	2.472e-26	121.0	COG3832@1|root,COG3832@2|Bacteria,2IN0A@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS2_k127_7155039_9	1219045.BV98_001639	9.131e-07	57.0	2ADQJ@1|root,313FX@2|Bacteria,1MYNR@1224|Proteobacteria,2UCQS@28211|Alphaproteobacteria,2K5ZN@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7155039_0	426117.M446_6062	1.857e-118	398.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,1JSMC@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
TLS2_k127_7155039_2	469383.Cwoe_0808	4.175e-45	170.0	COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria,4CQ7C@84995|Rubrobacteria	84995|Rubrobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	-	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
TLS2_k127_7155039_7	935567.JAES01000004_gene76	9.196e-13	78.0	2EGCD@1|root,33A46@2|Bacteria,1NMIX@1224|Proteobacteria,1SIUN@1236|Gammaproteobacteria,1X8EM@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
TLS2_k127_7155039_3	935845.JADQ01000044_gene3152	1.192e-30	127.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,4HACW@91061|Bacilli,26S45@186822|Paenibacillaceae	91061|Bacilli	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS09895	ADSL_C,Lyase_1
TLS2_k127_7195677_3	1206101.AZXC01000007_gene2590	5.867e-14	73.0	COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	1.14.15.7	ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
TLS2_k127_7195677_0	1077974.GOEFS_088_00150	1.54e-133	439.0	COG1231@1|root,COG1231@2|Bacteria,2GK23@201174|Actinobacteria,4GDC9@85026|Gordoniaceae	201174|Actinobacteria	E	Flavin containing amine oxidoreductase	puo	-	1.4.3.10,1.4.3.4	ko:K00274,ko:K03343	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R01151,R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS2_k127_7195677_2	485913.Krac_5258	1.014e-18	97.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	CheB_methylest,CheR,CheR_N,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
TLS2_k127_7195677_1	1122939.ATUD01000015_gene1005	4.913e-46	176.0	COG3897@1|root,COG3897@2|Bacteria,2GTAU@201174|Actinobacteria,4CQPT@84995|Rubrobacteria	84995|Rubrobacteria	S	Lysine methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_16
TLS2_k127_7195677_4	1454010.JEOE01000001_gene544	2.024e-06	59.0	COG1443@1|root,COG1443@2|Bacteria,2GM26@201174|Actinobacteria,4F1CE@85016|Cellulomonadaceae	201174|Actinobacteria	I	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)	idi	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
TLS2_k127_7242680_0	266117.Rxyl_1826	8.113e-208	654.0	COG0491@1|root,COG2897@1|root,COG0491@2|Bacteria,COG2897@2|Bacteria,2GN50@201174|Actinobacteria,4CQ9I@84995|Rubrobacteria	84995|Rubrobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
TLS2_k127_7242680_4	469383.Cwoe_1320	1.184e-18	86.0	COG0267@1|root,COG0267@2|Bacteria,2GQFG@201174|Actinobacteria,4CQU8@84995|Rubrobacteria	84995|Rubrobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
TLS2_k127_7242680_5	1137268.AZXF01000005_gene3037	1.79e-05	53.0	COG0690@1|root,COG0690@2|Bacteria,2GQFP@201174|Actinobacteria,4EKPQ@85012|Streptosporangiales	201174|Actinobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
TLS2_k127_7242680_1	469383.Cwoe_1322	1.066e-63	228.0	COG0250@1|root,COG0250@2|Bacteria,2GJFW@201174|Actinobacteria,4CQ4I@84995|Rubrobacteria	84995|Rubrobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
TLS2_k127_7242680_2	1380390.JIAT01000011_gene2555	3.198e-62	217.0	COG0080@1|root,COG0080@2|Bacteria,2IFCK@201174|Actinobacteria,4CQ3Y@84995|Rubrobacteria	84995|Rubrobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
TLS2_k127_7242680_3	1283299.AUKG01000001_gene2602	5.261e-20	98.0	COG0081@1|root,COG0081@2|Bacteria,2GM51@201174|Actinobacteria,4CPV5@84995|Rubrobacteria	84995|Rubrobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
TLS2_k127_7340193_2	1907.SGLAU_30840	2.352e-55	204.0	COG1073@1|root,COG1073@2|Bacteria,2I2KN@201174|Actinobacteria	201174|Actinobacteria	S	alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
TLS2_k127_7340193_3	675635.Psed_2126	1.289e-22	108.0	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,4E0RB@85010|Pseudonocardiales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS2_k127_7340193_4	196162.Noca_2118	7.002e-15	81.0	COG4244@1|root,COG4244@2|Bacteria,2II9W@201174|Actinobacteria	201174|Actinobacteria	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
TLS2_k127_7340193_0	1382356.JQMP01000003_gene1490	7.644e-290	918.0	COG0567@1|root,COG0567@2|Bacteria,2G638@200795|Chloroflexi,27XYT@189775|Thermomicrobia	189775|Thermomicrobia	C	2-oxoglutarate dehydrogenase N-terminus	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
TLS2_k127_7340193_1	1128421.JAGA01000002_gene1223	1.423e-85	293.0	COG0247@1|root,COG0247@2|Bacteria,2NNU8@2323|unclassified Bacteria	2|Bacteria	C	Cysteine-rich domain	glcF	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	iAPECO1_1312.glcF,iECABU_c1320.ECABU_c33760,iECIAI1_1343.ECIAI1_3119,iECIAI39_1322.ECIAI39_3465,iECNA114_1301.ECNA114_3053,iECP_1309.ECP_3055,iJN678.glcF,iJN746.PP_3747,iUTI89_1310.glcF,ic_1306.glcF	CCG,Fer4_7,Fer4_8
TLS2_k127_7371024_4	68219.JNXI01000040_gene5462	1.276e-40	163.0	COG5276@1|root,COG5276@2|Bacteria,2IBU7@201174|Actinobacteria	201174|Actinobacteria	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD,PA
TLS2_k127_7371024_0	526225.Gobs_0079	2.691e-171	559.0	COG0699@1|root,COG0699@2|Bacteria,2GJX9@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
TLS2_k127_7371024_1	1122611.KB903960_gene4337	2.014e-132	461.0	COG0699@1|root,COG0699@2|Bacteria,2GM68@201174|Actinobacteria,4EHPC@85012|Streptosporangiales	201174|Actinobacteria	S	50S ribosome-binding GTPase	PPA1638	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
TLS2_k127_7371024_5	913848.AELK01000180_gene952	1.332e-25	117.0	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,4HGZU@91061|Bacilli,3F4ZF@33958|Lactobacillaceae	91061|Bacilli	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TLS2_k127_7371024_2	469383.Cwoe_5341	2.049e-102	350.0	COG1940@1|root,COG3888@1|root,COG1940@2|Bacteria,COG3888@2|Bacteria,2GJ2S@201174|Actinobacteria,4CSEI@84995|Rubrobacteria	84995|Rubrobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2,ROK
TLS2_k127_7371024_3	1380390.JIAT01000011_gene2452	1.74e-79	289.0	COG4213@1|root,COG4213@2|Bacteria,2GKRE@201174|Actinobacteria,4CS1Y@84995|Rubrobacteria	84995|Rubrobacteria	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
TLS2_k127_7389108_8	1380347.JNII01000005_gene3498	0.0005888	47.0	28THW@1|root,2ZFRR@2|Bacteria,2GQMQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_7389108_2	1283299.AUKG01000006_gene795	1.173e-85	292.0	COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria,4CQIT@84995|Rubrobacteria	84995|Rubrobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	-	-	-	-	-	-	-	-	-	LGT
TLS2_k127_7389108_6	469383.Cwoe_3747	8.301e-36	154.0	COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria,4CQNN@84995|Rubrobacteria	84995|Rubrobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
TLS2_k127_7389108_5	469383.Cwoe_3746	2.93e-37	154.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,4CPY7@84995|Rubrobacteria	84995|Rubrobacteria	K	Segregation and condensation complex subunit ScpB	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
TLS2_k127_7389108_7	1157637.KB892102_gene1465	2.37e-17	89.0	COG4274@1|root,COG4274@2|Bacteria,2IN0N@201174|Actinobacteria	201174|Actinobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
TLS2_k127_7389108_3	997346.HMPREF9374_0412	7.857e-69	242.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,4H9MU@91061|Bacilli,27BJI@186824|Thermoactinomycetaceae	91061|Bacilli	J	RNA pseudouridylate synthase	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS2_k127_7389108_4	1386089.N865_18810	4.368e-52	186.0	COG3651@1|root,COG3651@2|Bacteria,2IHNI@201174|Actinobacteria,4FH7J@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2237)	-	-	-	ko:K09966	-	-	-	-	ko00000	-	-	-	DUF2237
TLS2_k127_7389108_1	1120971.AUCA01000021_gene1029	3.468e-111	368.0	COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,4HA1K@91061|Bacilli,2781H@186823|Alicyclobacillaceae	91061|Bacilli	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS2_k127_7389108_0	1283299.AUKG01000002_gene4648	2.181e-123	407.0	COG2876@1|root,COG2876@2|Bacteria,2I3UA@201174|Actinobacteria,4CPFQ@84995|Rubrobacteria	84995|Rubrobacteria	E	DAHP synthetase I family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
TLS2_k127_780224_0	469383.Cwoe_0017	4.115e-131	460.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4CPU4@84995|Rubrobacteria	84995|Rubrobacteria	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS2_k127_780224_2	469383.Cwoe_0016	2.709e-95	345.0	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,4CP9M@84995|Rubrobacteria	84995|Rubrobacteria	M	Penicillin binding protein transpeptidase domain	-	-	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
TLS2_k127_780224_1	469383.Cwoe_0015	2.409e-122	408.0	COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,4CPCV@84995|Rubrobacteria	84995|Rubrobacteria	D	Belongs to the SEDS family	-	-	-	-	-	-	-	-	-	-	-	-	FTSW_RODA_SPOVE
TLS2_k127_780224_3	469383.Cwoe_0014	5.613e-75	282.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4CQ6E@84995|Rubrobacteria	84995|Rubrobacteria	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
TLS2_k127_780224_5	266117.Rxyl_0025	6.899e-21	98.0	COG1716@1|root,COG1716@2|Bacteria,2HM1E@201174|Actinobacteria,4CQ7B@84995|Rubrobacteria	84995|Rubrobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
TLS2_k127_780224_4	1380390.JIAT01000009_gene1781	3.946e-61	229.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4CQB6@84995|Rubrobacteria	84995|Rubrobacteria	T	Protein of unknown function (DUF2662)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA
TLS2_k127_786200_1	313612.L8106_24905	2.75e-51	190.0	COG0500@1|root,COG2226@2|Bacteria,1G38U@1117|Cyanobacteria,1H9F3@1150|Oscillatoriales	1117|Cyanobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Sulfotransfer_1
TLS2_k127_786200_0	264732.Moth_1825	1.094e-53	199.0	COG0583@1|root,COG0583@2|Bacteria,1TSA6@1239|Firmicutes,24BM8@186801|Clostridia,42I6P@68295|Thermoanaerobacterales	186801|Clostridia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS2_k127_786200_3	1123024.AUII01000028_gene2491	4.286e-47	186.0	COG1454@1|root,COG1454@2|Bacteria,2I2FD@201174|Actinobacteria,4DXUH@85010|Pseudonocardiales	201174|Actinobacteria	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
TLS2_k127_786200_2	1126627.BAWE01000005_gene5686	1.092e-47	183.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_23,Methyltransf_25,Methyltransf_32
TLS2_k127_786200_4	479435.Kfla_4646	0.0003642	52.0	2F4R9@1|root,33XE7@2|Bacteria,2INJW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_851_2	1380390.JIAT01000014_gene6270	3.564e-75	259.0	COG1595@1|root,COG1595@2|Bacteria,2HQ0U@201174|Actinobacteria,4CRGS@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70 region 2	-	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS2_k127_851_0	1380390.JIAT01000009_gene365	1.714e-99	334.0	COG0438@1|root,COG0438@2|Bacteria,2HPUM@201174|Actinobacteria,4CR8J@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
TLS2_k127_851_1	35754.JNYJ01000065_gene5692	6.447e-83	302.0	COG1230@1|root,COG1230@2|Bacteria,2GMRZ@201174|Actinobacteria,4DBPK@85008|Micromonosporales	201174|Actinobacteria	P	cation diffusion facilitator family transporter	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
TLS2_k127_851_5	1463825.JNXC01000050_gene7425	7.982e-22	109.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria,4DYVZ@85010|Pseudonocardiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_851_6	469383.Cwoe_4476	1.974e-08	58.0	COG1314@1|root,COG1314@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
TLS2_k127_851_3	1380390.JIAT01000015_gene5803	2.195e-69	256.0	COG0312@1|root,COG0312@2|Bacteria,2GZPS@201174|Actinobacteria,4CQ2C@84995|Rubrobacteria	84995|Rubrobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
TLS2_k127_851_4	1380390.JIAT01000015_gene5804	1.494e-38	145.0	COG0312@1|root,COG0312@2|Bacteria,2GJ4E@201174|Actinobacteria,4CS03@84995|Rubrobacteria	84995|Rubrobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
TLS2_k127_89268_6	1298880.AUEV01000021_gene711	5.097e-07	53.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
TLS2_k127_89268_0	1283299.AUKG01000003_gene299	3.212e-134	455.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,4CR3F@84995|Rubrobacteria	84995|Rubrobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
TLS2_k127_89268_1	1051632.TPY_0864	8.261e-100	353.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,25E6Z@186801|Clostridia,3WDJU@538999|Clostridiales incertae sedis	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS2_k127_89268_2	469383.Cwoe_1157	1.935e-63	222.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4CQRQ@84995|Rubrobacteria	84995|Rubrobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
TLS2_k127_89268_5	1162668.LFE_1691	6.841e-12	75.0	COG0839@1|root,COG0839@2|Bacteria,3J0RP@40117|Nitrospirae	40117|Nitrospirae	C	Belongs to the complex I subunit 6 family	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS2_k127_89268_4	1380390.JIAT01000009_gene1153	6.836e-23	109.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria,4CQIE@84995|Rubrobacteria	84995|Rubrobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS2_k127_89268_3	1283299.AUKG01000003_gene294	4.24e-44	168.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4CPCM@84995|Rubrobacteria	84995|Rubrobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TLS2_k127_944839_0	469383.Cwoe_1816	3.901e-137	446.0	COG0438@1|root,COG0438@2|Bacteria,2GR58@201174|Actinobacteria,4CPE6@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS2_k127_944839_1	1048339.KB913029_gene4305	1.651e-33	145.0	2FB4M@1|root,343B0@2|Bacteria,2H8FD@201174|Actinobacteria	201174|Actinobacteria	S	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
TLS2_k127_947877_2	1122138.AQUZ01000019_gene8188	3.175e-78	266.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	sndH	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS2_k127_947877_0	1380390.JIAT01000010_gene4015	4.925e-220	717.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4CU4J@84995|Rubrobacteria	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS2_k127_947877_1	1380390.JIAT01000010_gene4014	7.642e-104	343.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CPWA@84995|Rubrobacteria	84995|Rubrobacteria	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS2_k127_947877_3	1193181.BN10_1150004	1.962e-21	103.0	COG1011@1|root,COG1011@2|Bacteria,2HX5F@201174|Actinobacteria,4FEU4@85021|Intrasporangiaceae	201174|Actinobacteria	S	Hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
TLS2_k127_947877_4	1125973.JNLC01000002_gene2076	1.247e-11	74.0	2C3PN@1|root,2ZT5C@2|Bacteria	2|Bacteria	G	peptidoglycan catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS2_k127_947877_5	1123023.JIAI01000004_gene8298	1.854e-05	55.0	COG3409@1|root,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,Peptidase_M15_4
TLS2_k127_968392_7	929712.KI912613_gene939	5.857e-07	58.0	COG1877@1|root,COG1877@2|Bacteria,2HP2R@201174|Actinobacteria,4CQDQ@84995|Rubrobacteria	84995|Rubrobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	-	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
TLS2_k127_968392_6	1177594.MIC448_1110028	5.658e-10	64.0	COG0730@1|root,COG0730@2|Bacteria,2I5VT@201174|Actinobacteria,4FNYV@85023|Microbacteriaceae	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_968392_5	504728.K649_04810	2.036e-13	81.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS2_k127_968392_3	756499.Desde_2180	1.94e-23	117.0	COG0739@1|root,COG0739@2|Bacteria,1TQMQ@1239|Firmicutes,24B3J@186801|Clostridia,261N2@186807|Peptococcaceae	186801|Clostridia	M	PFAM Peptidase family M23	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
TLS2_k127_968392_2	266117.Rxyl_1029	3.035e-88	313.0	COG0179@1|root,COG0179@2|Bacteria,2GN1K@201174|Actinobacteria,4CPUK@84995|Rubrobacteria	84995|Rubrobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
TLS2_k127_968392_1	649747.HMPREF0083_03279	1.897e-186	595.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4HB97@91061|Bacilli,26T63@186822|Paenibacillaceae	91061|Bacilli	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
TLS2_k127_968392_0	649747.HMPREF0083_04448	2.82e-201	661.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,4HA4I@91061|Bacilli,26TIA@186822|Paenibacillaceae	91061|Bacilli	Q	4-hydroxyphenylacetate 3-hydroxylase N terminal	yoaI	-	1.14.14.9	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	-	R02698,R03299	RC00046	ko00000,ko00001,ko01000	-	-	-	HpaB,HpaB_N
TLS2_k127_968392_4	1123023.JIAI01000015_gene3351	2.36e-16	93.0	COG1853@1|root,COG1853@2|Bacteria,2GMPH@201174|Actinobacteria,4E4PC@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM flavin reductase domain protein FMN-binding	-	-	-	ko:K14631,ko:K21185	ko01057,ko01059,ko01130,map01057,map01059,map01130	M00779,M00827,M00828,M00832	R05705,R11368,R11393	RC00126,RC00949,RC03431	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavin_Reduct
TLS2_k127_974005_2	1380390.JIAT01000014_gene6206	1.074e-37	165.0	COG1074@1|root,COG1074@2|Bacteria,2GNKH@201174|Actinobacteria,4CPD7@84995|Rubrobacteria	84995|Rubrobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS2_k127_974005_0	469383.Cwoe_1804	2.622e-108	386.0	COG3857@1|root,COG3857@2|Bacteria,2HNUC@201174|Actinobacteria,4CQ2I@84995|Rubrobacteria	84995|Rubrobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
TLS2_k127_974005_4	1163409.UUA_00740	6.21e-05	56.0	COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,1RQ8F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Nitrous oxidase accessory protein	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
TLS2_k127_974005_3	797304.Natgr_1088	6.433e-08	64.0	arCOG11370@1|root,arCOG11370@2157|Archaea,2XU94@28890|Euryarchaeota,23UV5@183963|Halobacteria	183963|Halobacteria	S	flavoprotein involved in K transport	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_9
TLS2_k127_974005_1	1380390.JIAT01000009_gene1535	6.773e-91	303.0	COG0395@1|root,COG0395@2|Bacteria,2GJNN@201174|Actinobacteria,4CRU9@84995|Rubrobacteria	84995|Rubrobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10234	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
TLS2_k127_984074_4	2074.JNYD01000011_gene143	1.109e-46	173.0	COG0282@1|root,COG0282@2|Bacteria,2GJAW@201174|Actinobacteria,4DYVV@85010|Pseudonocardiales	201174|Actinobacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
TLS2_k127_984074_1	1240349.ANGC01000007_gene1323	2.771e-124	424.0	COG3064@1|root,COG3064@2|Bacteria,2I5UC@201174|Actinobacteria,4GA0F@85025|Nocardiaceae	201174|Actinobacteria	M	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
TLS2_k127_984074_3	1283283.ATXA01000002_gene2416	1.266e-50	204.0	COG2197@1|root,COG2197@2|Bacteria,2IIZS@201174|Actinobacteria	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS2_k127_984074_2	1122939.ATUD01000001_gene812	8.332e-108	370.0	COG3850@1|root,COG3850@2|Bacteria,2GIWI@201174|Actinobacteria,4CU6T@84995|Rubrobacteria	84995|Rubrobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
TLS2_k127_984074_0	469383.Cwoe_1723	1.246e-152	500.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4CRWU@84995|Rubrobacteria	84995|Rubrobacteria	P	ATPase (P-type)	-	-	3.6.3.8	ko:K01537,ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.2,3.A.3.23	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
## 2468 queries scanned
## Total time (seconds): 162.0243694782257
## Rate: 15.23 q/s